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Search of human proteins with 208431829
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208431829 eukaryotic translation initiation factor 2-alpha
kinase 2 isoform b [Homo sapiens]
(510 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208431829 eukaryotic translation initiation factor 2-alpha ki... 1013 0.0
gi|208431827 eukaryotic translation initiation factor 2-alpha ki... 993 0.0
gi|4506103 eukaryotic translation initiation factor 2-alpha kina... 993 0.0
gi|134304838 eukaryotic translation initiation factor 2-alpha ki... 131 1e-30
gi|65287717 eukaryotic translation initiation factor 2 alpha kin... 115 1e-25
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 114 2e-25
gi|197245437 eukaryotic translation initiation factor 2-alpha ki... 106 4e-23
gi|11125768 eukaryotic translation initiation factor 2-alpha kin... 106 4e-23
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 101 2e-21
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 100 2e-21
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 99 1e-20
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 99 1e-20
gi|21359873 polo-like kinase 1 [Homo sapiens] 96 6e-20
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 96 8e-20
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 96 8e-20
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 96 8e-20
gi|93004081 polo-like kinase 2 [Homo sapiens] 94 3e-19
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 89 9e-18
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 89 9e-18
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 89 9e-18
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 88 2e-17
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 88 2e-17
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 86 8e-17
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 86 1e-16
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 86 1e-16
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 86 1e-16
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 86 1e-16
gi|41872374 polo-like kinase 3 [Homo sapiens] 85 1e-16
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 84 3e-16
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 84 3e-16
>gi|208431829 eukaryotic translation initiation factor 2-alpha
kinase 2 isoform b [Homo sapiens]
Length = 510
Score = 1013 bits (2619), Expect = 0.0
Identities = 510/510 (100%), Positives = 510/510 (100%)
Query: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
Sbjct: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
Query: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
Sbjct: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
Query: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
Sbjct: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
Query: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
Sbjct: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
Query: 241 RSLAPRFDLPDMKETKYTVDKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSL 300
RSLAPRFDLPDMKETKYTVDKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSL
Sbjct: 241 RSLAPRFDLPDMKETKYTVDKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSL 300
Query: 301 ESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG 360
ESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG
Sbjct: 301 ESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG 360
Query: 361 VDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQIS 420
VDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQIS
Sbjct: 361 VDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQIS 420
Query: 421 SQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSK 480
SQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSK
Sbjct: 421 SQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSK 480
Query: 481 KPEDRPNTSEILRTLTVWKKSPEKNERHTC 510
KPEDRPNTSEILRTLTVWKKSPEKNERHTC
Sbjct: 481 KPEDRPNTSEILRTLTVWKKSPEKNERHTC 510
>gi|208431827 eukaryotic translation initiation factor 2-alpha
kinase 2 isoform a [Homo sapiens]
Length = 551
Score = 993 bits (2567), Expect = 0.0
Identities = 510/551 (92%), Positives = 510/551 (92%), Gaps = 41/551 (7%)
Query: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
Sbjct: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
Query: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
Sbjct: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
Query: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
Sbjct: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
Query: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
Sbjct: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
Query: 241 RSLAPRFDLPDMKETKYTVDKR-------------------------------------- 262
RSLAPRFDLPDMKETKYTVDKR
Sbjct: 241 RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY 300
Query: 263 ---KAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 319
KAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
Sbjct: 301 NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 360
Query: 320 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 379
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
Sbjct: 361 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
Query: 380 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 439
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
Sbjct: 421 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 480
Query: 440 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 499
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
Sbjct: 481 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 540
Query: 500 KSPEKNERHTC 510
KSPEKNERHTC
Sbjct: 541 KSPEKNERHTC 551
>gi|4506103 eukaryotic translation initiation factor 2-alpha kinase
2 isoform a [Homo sapiens]
Length = 551
Score = 993 bits (2567), Expect = 0.0
Identities = 510/551 (92%), Positives = 510/551 (92%), Gaps = 41/551 (7%)
Query: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
Sbjct: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
Query: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
Sbjct: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
Query: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
Sbjct: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
Query: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
Sbjct: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
Query: 241 RSLAPRFDLPDMKETKYTVDKR-------------------------------------- 262
RSLAPRFDLPDMKETKYTVDKR
Sbjct: 241 RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY 300
Query: 263 ---KAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 319
KAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
Sbjct: 301 NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 360
Query: 320 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 379
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
Sbjct: 361 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
Query: 380 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 439
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
Sbjct: 421 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 480
Query: 440 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 499
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
Sbjct: 481 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 540
Query: 500 KSPEKNERHTC 510
KSPEKNERHTC
Sbjct: 541 KSPEKNERHTC 551
>gi|134304838 eukaryotic translation initiation factor 2-alpha kinase
3 [Homo sapiens]
Length = 1116
Score = 131 bits (330), Expect = 1e-30
Identities = 75/189 (39%), Positives = 108/189 (57%), Gaps = 17/189 (8%)
Query: 321 LFIQMEFCDKGTLEQWIEKRRG-EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 379
L+IQM+ C K L+ W+ R E+ ++ + L +F QI + V+++HSK L+HRDLKPSNI
Sbjct: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
Query: 380 FLVDTKQVKIGDFGLVTSLKND-------------GKRTRSKGTLRYMSPEQISSQDYGK 426
F VK+GDFGLVT++ D + T GT YMSPEQI Y
Sbjct: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003
Query: 427 EVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPE 483
+VD+++LGLIL ELL+ T E + TD+R+ +F +K E ++Q +LS P
Sbjct: 1004 KVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPM 1063
Query: 484 DRPNTSEIL 492
+RP I+
Sbjct: 1064 ERPEAINII 1072
Score = 33.9 bits (76), Expect = 0.36
Identities = 15/26 (57%), Positives = 17/26 (65%)
Query: 261 KRKAEREVKALAKLDHVNIVHYNGCW 286
+ K REVKALAKL+H IV Y W
Sbjct: 633 REKVMREVKALAKLEHPGIVRYFNAW 658
>gi|65287717 eukaryotic translation initiation factor 2 alpha kinase 4
[Homo sapiens]
Length = 1649
Score = 115 bits (287), Expect = 1e-25
Identities = 88/254 (34%), Positives = 123/254 (48%), Gaps = 36/254 (14%)
Query: 289 FDYDPETSDDSLESSDYDPENSKNSSRSKTKC-----LFIQMEFCDKGTLEQWIEKRRGE 343
FD + E S + D + +N + S L+IQME+C+K TL I++ G
Sbjct: 761 FDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQ--GL 818
Query: 344 KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS------ 397
D V LF +I G+ YIH K +IHRDLKP NIFL VKIGDFGL T
Sbjct: 819 YRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSA 878
Query: 398 -----------LKND--GKRTRSKGTLRYMSPEQISS--QDYGKEVDLYALGLILAEL-L 441
+K+D G T GT Y+SPE S Y ++VDL++LG+I E+
Sbjct: 879 DSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSY 938
Query: 442 HVCDTAFETSKFFTDLRDGI---ISDIFD----KKEKTLLQKLLSKKPEDRPNTSEILRT 494
H TA E LRD + FD K+K+++ LL+ P RP +E+L++
Sbjct: 939 HPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKS 998
Query: 495 LTVWKKSPEKNERH 508
+ E++E H
Sbjct: 999 ELLPPPQMEESELH 1012
Score = 43.1 bits (100), Expect = 6e-04
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 356 QITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMS 415
Q+ G+DY+HS ++H+ L SN+ + VKI D+ + L + K + T R
Sbjct: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQT-RVRF 466
Query: 416 PEQISSQDYGKEVDLYALGLILAEL 440
+ GK+ D++ LGL+L L
Sbjct: 467 SDNALPYKTGKKGDVWRLGLLLLSL 491
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 114 bits (286), Expect = 2e-25
Identities = 73/240 (30%), Positives = 122/240 (50%), Gaps = 34/240 (14%)
Query: 260 DKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 319
++R AE+E + L++L H NIV Y W+G D
Sbjct: 46 ERRAAEQEAQLLSQLKHPNIVTYKESWEGGD----------------------------G 77
Query: 320 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 379
L+I M FC+ G L + +++++G+ L + +E F QI + Y+H K ++HRDLK N+
Sbjct: 78 LLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNV 137
Query: 380 FLVDTKQVKIGDFGLVTSLKNDGKRTRSK-GTLRYMSPEQISSQDYGKEVDLYALGLILA 438
FL T +K+GD G+ L+N + GT YMSPE S++ Y + D++ALG +
Sbjct: 138 FLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVY 197
Query: 439 EL--LHVCDTAFETSKFFTDLRDGIISDI---FDKKEKTLLQKLLSKKPEDRPNTSEILR 493
E+ L A + + + +G + + + + L++ +LSK+PE+RP+ ILR
Sbjct: 198 EMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILR 257
>gi|197245437 eukaryotic translation initiation factor 2-alpha
kinase 1 isoform b [Homo sapiens]
Length = 629
Score = 106 bits (265), Expect = 4e-23
Identities = 92/325 (28%), Positives = 148/325 (45%), Gaps = 40/325 (12%)
Query: 207 DFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVD------ 260
D D + +D +SSS++ K KR + + K KYT +
Sbjct: 258 DQEEDREQCGVKNDESSSSSIIF--AEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRES 315
Query: 261 ---KRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSK 317
+ E + LA L +IV + E+ + ESS+ + +
Sbjct: 316 GELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQY 375
Query: 318 TKCLFIQMEFCDKGTLEQWI---EKRRGEKLDKV--------LALELFEQITKGVDYIHS 366
L IQM+ C+ +L WI KR E +D+ +A ++F+++ +GV YIH+
Sbjct: 376 HLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHN 434
Query: 367 KKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS---------LKNDGKRTRSK----GTLR 412
++HRDLKP NIFL +QVKIGDFGL + +GKRT + GT
Sbjct: 435 MGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCL 494
Query: 413 YMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKK--- 469
Y SPEQ+ +Y + D+Y+LG++L EL T E ++ T LR G + + K+
Sbjct: 495 YASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPV 554
Query: 470 EKTLLQKLLSKKPEDRPNTSEILRT 494
+ +Q L + RP+ ++L++
Sbjct: 555 QAKYIQHLTRRNSSQRPSAIQLLQS 579
Score = 30.0 bits (66), Expect = 5.2
Identities = 14/24 (58%), Positives = 15/24 (62%)
Query: 263 KAEREVKALAKLDHVNIVHYNGCW 286
K REVK LA L H NIV Y+ W
Sbjct: 210 KVLREVKVLAGLQHPNIVGYHTAW 233
>gi|11125768 eukaryotic translation initiation factor 2-alpha kinase
1 isoform a [Homo sapiens]
Length = 630
Score = 106 bits (265), Expect = 4e-23
Identities = 92/325 (28%), Positives = 148/325 (45%), Gaps = 40/325 (12%)
Query: 207 DFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAKRSLAPRFDLPDMKETKYTVD------ 260
D D + +D +SSS++ K KR + + K KYT +
Sbjct: 259 DQEEDREQCGVKNDESSSSSIIF--AEPTPEKEKRFGESDTENQNNKSVKYTTNLVIRES 316
Query: 261 ---KRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSK 317
+ E + LA L +IV + E+ + ESS+ + +
Sbjct: 317 GELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEESSEENVNFLGQTEAQY 376
Query: 318 TKCLFIQMEFCDKGTLEQWI---EKRRGEKLDKV--------LALELFEQITKGVDYIHS 366
L IQM+ C+ +L WI KR E +D+ +A ++F+++ +GV YIH+
Sbjct: 377 HLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESACPYVMANVATKIFQELVEGVFYIHN 435
Query: 367 KKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS---------LKNDGKRTRSK----GTLR 412
++HRDLKP NIFL +QVKIGDFGL + +GKRT + GT
Sbjct: 436 MGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRNGKRTPTHTSRVGTCL 495
Query: 413 YMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKK--- 469
Y SPEQ+ +Y + D+Y+LG++L EL T E ++ T LR G + + K+
Sbjct: 496 YASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGLRTGQLPESLRKRCPV 555
Query: 470 EKTLLQKLLSKKPEDRPNTSEILRT 494
+ +Q L + RP+ ++L++
Sbjct: 556 QAKYIQHLTRRNSSQRPSAIQLLQS 580
Score = 30.0 bits (66), Expect = 5.2
Identities = 14/24 (58%), Positives = 15/24 (62%)
Query: 263 KAEREVKALAKLDHVNIVHYNGCW 286
K REVK LA L H NIV Y+ W
Sbjct: 210 KVLREVKVLAGLQHPNIVGYHTAW 233
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 101 bits (251), Expect = 2e-21
Identities = 80/263 (30%), Positives = 124/263 (47%), Gaps = 39/263 (14%)
Query: 237 RKAKRSLAPRFDLPDMKETKYTVDKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETS 296
RKA + L +P + TK +++ A+ E + L L+H N++ Y ++ F D
Sbjct: 23 RKADQKLVIIKQIPVEQMTKE--ERQAAQNECQVLKLLNHPNVIEY---YENFLED---- 73
Query: 297 DDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQ 356
K L I ME+ GTL ++I+KR L++ L F Q
Sbjct: 74 ----------------------KALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQ 111
Query: 357 ITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ-VKIGDFGLVTSLKNDGKRTRSKGTLRYMS 415
I + ++H+ ++HRDLK NI L + VKIGDFG+ L + K GT Y+S
Sbjct: 112 ILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYIS 171
Query: 416 PEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSK---FFTDLRDGI---ISDIFDKK 469
PE + Y ++ D++ALG +L EL + AFE + + G ISD + +
Sbjct: 172 PELCEGKPYNQKSDIWALGCVLYELASL-KRAFEAANLPALVLKIMSGTFAPISDRYSPE 230
Query: 470 EKTLLQKLLSKKPEDRPNTSEIL 492
+ L+ LLS +P RP S I+
Sbjct: 231 LRQLVLSLLSLEPAQRPPLSHIM 253
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 100 bits (250), Expect = 2e-21
Identities = 75/252 (29%), Positives = 116/252 (46%), Gaps = 58/252 (23%)
Query: 260 DKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 319
+K +++EV L K+ H NIV + + EN +
Sbjct: 44 EKEASKKEVILLEKMKHPNIVAFFNSFQ--------------------ENGR-------- 75
Query: 320 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 379
LFI ME+CD G L + I ++RG + L F QI+ G+ +IH +K++HRD+K NI
Sbjct: 76 -LFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNI 134
Query: 380 FLVDTKQV-KIGDFGLVTSLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLIL 437
FL V K+GDFG+ L N + R+ GT Y+SPE ++ Y + D+++LG +L
Sbjct: 135 FLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVL 194
Query: 438 AEL----------------LHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKK 481
EL L +C F IS F ++ +L+ +L
Sbjct: 195 YELCTLKHPFEGNNLQQLVLKICQAHFAP-----------ISPGFSRELHSLISQLFQVS 243
Query: 482 PEDRPNTSEILR 493
P DRP+ + IL+
Sbjct: 244 PRDRPSINSILK 255
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 98.6 bits (244), Expect = 1e-20
Identities = 76/246 (30%), Positives = 119/246 (48%), Gaps = 40/246 (16%)
Query: 260 DKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 319
+K+ EV L +L H NIV Y YD + R+ T
Sbjct: 48 EKQMLVSEVNLLRELKHPNIVRY----------------------YD----RIIDRTNTT 81
Query: 320 CLFIQMEFCDKGTLEQWIEKRRGEK--LDKVLALELFEQITKGVDYIHSKK-----LIHR 372
L+I ME+C+ G L I K E+ LD+ L + Q+T + H + ++HR
Sbjct: 82 -LYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHR 140
Query: 373 DLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLY 431
DLKP+N+FL + VK+GDFGL L +D ++ GT YMSPEQ++ Y ++ D++
Sbjct: 141 DLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIW 200
Query: 432 ALGLILAELLHVCD--TAFETSKFFTDLRDGIISDI---FDKKEKTLLQKLLSKKPEDRP 486
+LG +L EL + TAF + +R+G I + + ++ ++L+ K RP
Sbjct: 201 SLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRP 260
Query: 487 NTSEIL 492
+ EIL
Sbjct: 261 SVEEIL 266
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 98.6 bits (244), Expect = 1e-20
Identities = 71/241 (29%), Positives = 116/241 (48%), Gaps = 39/241 (16%)
Query: 260 DKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 319
++ ++ REV LA + H NIV Y ++ +N S
Sbjct: 44 EREESRREVAVLANMKHPNIVQYRESFE-----------------------ENGS----- 75
Query: 320 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 379
L+I M++C+ G L + I ++G + L+ F QI + ++H +K++HRD+K NI
Sbjct: 76 -LYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNI 134
Query: 380 FLVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLILA 438
FL V++GDFG+ L + + R+ GT Y+SPE ++ Y + D++ALG +L
Sbjct: 135 FLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLY 194
Query: 439 ELLHVCDTAFETSKFFTDLRDGIISDIFDKKE-------KTLLQKLLSKKPEDRPNTSEI 491
EL AFE +L IIS F ++L+ +L + P DRP+ + I
Sbjct: 195 ELC-TLKHAFEAGS-MKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSI 252
Query: 492 L 492
L
Sbjct: 253 L 253
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 96.3 bits (238), Expect = 6e-20
Identities = 66/178 (37%), Positives = 103/178 (57%), Gaps = 9/178 (5%)
Query: 321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
+F+ +E C + +L + + KRR + L + A QI G Y+H ++IHRDLK N+F
Sbjct: 126 VFVVLELCRRRSLLE-LHKRR-KALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLF 183
Query: 381 LVDTKQVKIGDFGLVTSLKNDGKRTRSK-GTLRYMSPEQISSQDYGKEVDLYALGLILAE 439
L + +VKIGDFGL T ++ DG+R ++ GT Y++PE +S + + EVD++++G I+
Sbjct: 184 LNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYT 243
Query: 440 LLHVCDTAFETSKF-FTDLR----DGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEIL 492
LL V FETS T LR + I + +L+QK+L P RP +E+L
Sbjct: 244 LL-VGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL 300
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 95.9 bits (237), Expect = 8e-20
Identities = 70/252 (27%), Positives = 120/252 (47%), Gaps = 35/252 (13%)
Query: 247 FDLPDMKETKYTVDKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYD 306
F + +++ K + + + +E LAK+ H NIV + +S E+ +
Sbjct: 30 FAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFK--------------ESFEAEGH- 74
Query: 307 PENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHS 366
L+I ME+CD G L Q I++++G+ + + L F Q+ GV++IH
Sbjct: 75 --------------LYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
Query: 367 KKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKND-GKRTRSKGTLRYMSPEQISSQDYG 425
K+++HRD+K NIFL +VK+GDFG L N GT Y+ PE + Y
Sbjct: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
Query: 426 KEVDLYALGLILAEL--LHVCDTAFETSKFFTDLRDGIISDI---FDKKEKTLLQKLLSK 480
+ D+++LG IL EL L A + G IS + + + + L++++ +
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
Query: 481 KPEDRPNTSEIL 492
P RP+ + +L
Sbjct: 241 NPSHRPSATTLL 252
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 95.9 bits (237), Expect = 8e-20
Identities = 70/252 (27%), Positives = 120/252 (47%), Gaps = 35/252 (13%)
Query: 247 FDLPDMKETKYTVDKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYD 306
F + +++ K + + + +E LAK+ H NIV + +S E+ +
Sbjct: 30 FAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFK--------------ESFEAEGH- 74
Query: 307 PENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHS 366
L+I ME+CD G L Q I++++G+ + + L F Q+ GV++IH
Sbjct: 75 --------------LYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
Query: 367 KKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKND-GKRTRSKGTLRYMSPEQISSQDYG 425
K+++HRD+K NIFL +VK+GDFG L N GT Y+ PE + Y
Sbjct: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
Query: 426 KEVDLYALGLILAEL--LHVCDTAFETSKFFTDLRDGIISDI---FDKKEKTLLQKLLSK 480
+ D+++LG IL EL L A + G IS + + + + L++++ +
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
Query: 481 KPEDRPNTSEIL 492
P RP+ + +L
Sbjct: 241 NPSHRPSATTLL 252
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 95.9 bits (237), Expect = 8e-20
Identities = 70/252 (27%), Positives = 120/252 (47%), Gaps = 35/252 (13%)
Query: 247 FDLPDMKETKYTVDKRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYD 306
F + +++ K + + + +E LAK+ H NIV + +S E+ +
Sbjct: 30 FAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFK--------------ESFEAEGH- 74
Query: 307 PENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHS 366
L+I ME+CD G L Q I++++G+ + + L F Q+ GV++IH
Sbjct: 75 --------------LYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHK 120
Query: 367 KKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKND-GKRTRSKGTLRYMSPEQISSQDYG 425
K+++HRD+K NIFL +VK+GDFG L N GT Y+ PE + Y
Sbjct: 121 KRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYN 180
Query: 426 KEVDLYALGLILAEL--LHVCDTAFETSKFFTDLRDGIISDI---FDKKEKTLLQKLLSK 480
+ D+++LG IL EL L A + G IS + + + + L++++ +
Sbjct: 181 NKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKR 240
Query: 481 KPEDRPNTSEIL 492
P RP+ + +L
Sbjct: 241 NPSHRPSATTLL 252
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 94.0 bits (232), Expect = 3e-19
Identities = 55/179 (30%), Positives = 98/179 (54%), Gaps = 9/179 (5%)
Query: 321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
++I +E+C + ++ ++ R+ L + QI G+ Y+H ++++HRDLK N F
Sbjct: 155 IYILLEYCSRRSMAHILKARK--VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFF 212
Query: 381 LVDTKQVKIGDFGLVTSLKN-DGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 439
+ + ++K+GDFGL L+ + +R GT Y+SPE ++ Q +G E D++ALG ++
Sbjct: 213 INEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYT 272
Query: 440 LL-----HVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 493
+L ET + + R + S + K L+ +LSK PEDRP+ +I+R
Sbjct: 273 MLLGRPPFETTNLKETYRCIREARYTMPSSLL-APAKHLIASMLSKNPEDRPSLDDIIR 330
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 89.0 bits (219), Expect = 9e-18
Identities = 69/240 (28%), Positives = 115/240 (47%), Gaps = 40/240 (16%)
Query: 263 KAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF 322
+A E + L+KLDH IV ++ + +E ++ C+
Sbjct: 75 QANLEAQLLSKLDHPAIVKFHASF-------------VEQDNF--------------CII 107
Query: 323 IQMEFCDKGTLEQWIE--KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
E+C+ L+ I+ K+ G+ + +E F Q+ GVDY+H ++++HRDLK N+F
Sbjct: 108 T--EYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVF 165
Query: 381 LVDTKQVKIGDFGLVTSLKND-GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 439
L +KIGDFG+ L T GT YMSPE + Q Y + D+++L IL E
Sbjct: 166 L-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYE 224
Query: 440 LLHVCDTAFETSKFFTDLRDGIISDI------FDKKEKTLLQKLLSKKPEDRPNTSEILR 493
+ + AF S F + + + D + K+ +++ +L+K P RP+ EIL+
Sbjct: 225 MC-CMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILK 283
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 89.0 bits (219), Expect = 9e-18
Identities = 69/240 (28%), Positives = 115/240 (47%), Gaps = 40/240 (16%)
Query: 263 KAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF 322
+A E + L+KLDH IV ++ + +E ++ C+
Sbjct: 75 QANLEAQLLSKLDHPAIVKFHASF-------------VEQDNF--------------CII 107
Query: 323 IQMEFCDKGTLEQWIE--KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
E+C+ L+ I+ K+ G+ + +E F Q+ GVDY+H ++++HRDLK N+F
Sbjct: 108 T--EYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVF 165
Query: 381 LVDTKQVKIGDFGLVTSLKND-GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 439
L +KIGDFG+ L T GT YMSPE + Q Y + D+++L IL E
Sbjct: 166 L-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYE 224
Query: 440 LLHVCDTAFETSKFFTDLRDGIISDI------FDKKEKTLLQKLLSKKPEDRPNTSEILR 493
+ + AF S F + + + D + K+ +++ +L+K P RP+ EIL+
Sbjct: 225 MC-CMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILK 283
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 89.0 bits (219), Expect = 9e-18
Identities = 69/240 (28%), Positives = 115/240 (47%), Gaps = 40/240 (16%)
Query: 263 KAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF 322
+A E + L+KLDH IV ++ + +E ++ C+
Sbjct: 75 QANLEAQLLSKLDHPAIVKFHASF-------------VEQDNF--------------CII 107
Query: 323 IQMEFCDKGTLEQWIE--KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
E+C+ L+ I+ K+ G+ + +E F Q+ GVDY+H ++++HRDLK N+F
Sbjct: 108 T--EYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVF 165
Query: 381 LVDTKQVKIGDFGLVTSLKND-GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 439
L +KIGDFG+ L T GT YMSPE + Q Y + D+++L IL E
Sbjct: 166 L-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYE 224
Query: 440 LLHVCDTAFETSKFFTDLRDGIISDI------FDKKEKTLLQKLLSKKPEDRPNTSEILR 493
+ + AF S F + + + D + K+ +++ +L+K P RP+ EIL+
Sbjct: 225 MC-CMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIMESMLNKNPSLRPSAIEILK 283
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 88.2 bits (217), Expect = 2e-17
Identities = 69/259 (26%), Positives = 113/259 (43%), Gaps = 39/259 (15%)
Query: 260 DKRKAEREVKALAKLDHVNIV-HYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKT 318
++R A E+ LA L H NI+ +YN D
Sbjct: 92 ERRDALNEIVILALLQHDNIIAYYNHFMDN------------------------------ 121
Query: 319 KCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSN 378
L I++E+C+ G L I +++ + ++ + + QI V IH ++HRD+K N
Sbjct: 122 TTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLN 181
Query: 379 IFLVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLIL 437
IFL +K+GD+GL L ++ + GT YMSPE Y + D++A+G ++
Sbjct: 182 IFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVI 241
Query: 438 AELLHVCDTAFETS--KFFTDLRDGIISDIFDKKEKTL-----LQKLLSKKPEDRPNTSE 490
ELL + T T+ + GI + D + +L + L + PE RP E
Sbjct: 242 FELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADE 301
Query: 491 ILRTLTVWKKSPEKNERHT 509
+L + K+ E E+ T
Sbjct: 302 LLDRPLLRKRRREMEEKVT 320
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 87.8 bits (216), Expect = 2e-17
Identities = 53/181 (29%), Positives = 87/181 (48%), Gaps = 31/181 (17%)
Query: 261 KRKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKC 320
+ + E ++K L KL H NI+ + G ++ C
Sbjct: 198 REQNETDIKHLRKLKHPNIIAFKGVC-----------------------------TQAPC 228
Query: 321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
I ME+C G L + + R G K+ L ++ I G++Y+H K+IHRDLK N+
Sbjct: 229 YCIIMEYCAHGQLYEVL--RAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVL 286
Query: 381 LVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL 440
+ T VKI DFG L + + GT+ +M+PE I ++ ++VD+++ G++L EL
Sbjct: 287 VTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWEL 346
Query: 441 L 441
L
Sbjct: 347 L 347
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 85.9 bits (211), Expect = 8e-17
Identities = 63/178 (35%), Positives = 94/178 (52%), Gaps = 13/178 (7%)
Query: 322 FIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFL 381
F+ ME+ G L +I K +++++ A LF+QI VDY H ++HRDLKP N+ L
Sbjct: 90 FMVMEYVSGGELFDYICKHG--RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLL 147
Query: 382 VDTKQVKIGDFGLVTSLKNDGKRTR-SKGTLRYMSPEQISSQDY-GKEVDLYALGLILAE 439
KI DFGL +++ +DG+ R S G+ Y +PE IS + Y G EVD+++ G+IL
Sbjct: 148 DAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYA 206
Query: 440 LLHVCDTA----FETSKFFTDLRDGI--ISDIFDKKEKTLLQKLLSKKPEDRPNTSEI 491
LL C T F +R G+ I + ++ TLL +L P R +I
Sbjct: 207 LL--CGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDI 262
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 85.5 bits (210), Expect = 1e-16
Identities = 67/240 (27%), Positives = 108/240 (45%), Gaps = 39/240 (16%)
Query: 265 EREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQ 324
E ++K L KL H NI+ + G ++ C I
Sbjct: 159 ETDIKHLRKLKHPNIITFKGVC-----------------------------TQAPCYCIL 189
Query: 325 MEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT 384
MEFC +G L + + R G + L ++ I G++Y+H K+IHRDLK N+ +
Sbjct: 190 MEFCAQGQLYEVL--RAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYD 247
Query: 385 KQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL--- 441
VKI DFG L + + GT+ +M+PE I ++ ++VD+++ G++L ELL
Sbjct: 248 DVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGE 307
Query: 442 ----HVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV 497
V +A L + S D K LL++ + KP +RP+ +IL L +
Sbjct: 308 IPYKDVDSSAIIWGVGSNSLHLPVPSSCPD-GFKILLRQCWNSKPRNRPSFRQILLHLDI 366
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 85.5 bits (210), Expect = 1e-16
Identities = 55/178 (30%), Positives = 96/178 (53%), Gaps = 9/178 (5%)
Query: 321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
+++ +E+ +G L + ++K EKLD+ + E++ + Y H KK+IHRD+KP N+
Sbjct: 82 VYLILEYAPRGELYKELQK--SEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLL 139
Query: 381 LVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL 440
L +VKI DFG + ++T GTL Y+ PE I + Y ++VDL+ +G++ EL
Sbjct: 140 LGFRGEVKIADFGWSVHTPSLRRKTMC-GTLDYLPPEMIEGRTYDEKVDLWCIGVLCYEL 198
Query: 441 LHVCDTAFETSKFFTDLRDGIISDI-----FDKKEKTLLQKLLSKKPEDRPNTSEILR 493
L V FE++ R + D+ + L+ +LL +P +R ++IL+
Sbjct: 199 L-VGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILK 255
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 85.5 bits (210), Expect = 1e-16
Identities = 55/178 (30%), Positives = 96/178 (53%), Gaps = 9/178 (5%)
Query: 321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
+++ +E+ +G L + ++K EKLD+ + E++ + Y H KK+IHRD+KP N+
Sbjct: 97 VYLILEYAPRGELYKELQK--SEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLL 154
Query: 381 LVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL 440
L +VKI DFG + ++T GTL Y+ PE I + Y ++VDL+ +G++ EL
Sbjct: 155 LGFRGEVKIADFGWSVHTPSLRRKTMC-GTLDYLPPEMIEGRTYDEKVDLWCIGVLCYEL 213
Query: 441 LHVCDTAFETSKFFTDLRDGIISDI-----FDKKEKTLLQKLLSKKPEDRPNTSEILR 493
L V FE++ R + D+ + L+ +LL +P +R ++IL+
Sbjct: 214 L-VGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILK 270
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 85.5 bits (210), Expect = 1e-16
Identities = 55/178 (30%), Positives = 96/178 (53%), Gaps = 9/178 (5%)
Query: 321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
+++ +E+ +G L + ++K EKLD+ + E++ + Y H KK+IHRD+KP N+
Sbjct: 116 VYLILEYAPRGELYKELQK--SEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLL 173
Query: 381 LVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL 440
L +VKI DFG + ++T GTL Y+ PE I + Y ++VDL+ +G++ EL
Sbjct: 174 LGFRGEVKIADFGWSVHTPSLRRKTMC-GTLDYLPPEMIEGRTYDEKVDLWCIGVLCYEL 232
Query: 441 LHVCDTAFETSKFFTDLRDGIISDI-----FDKKEKTLLQKLLSKKPEDRPNTSEILR 493
L V FE++ R + D+ + L+ +LL +P +R ++IL+
Sbjct: 233 L-VGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILK 289
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 85.1 bits (209), Expect = 1e-16
Identities = 57/180 (31%), Positives = 94/180 (52%), Gaps = 11/180 (6%)
Query: 321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
++I +E C + +L I K R L+ + L QI G+ Y+H + ++HRDLK N F
Sbjct: 135 IYIFLELCSRKSLAH-IWKARHTLLEPEVRYYL-RQILSGLKYLHQRGILHRDLKLGNFF 192
Query: 381 LVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLILAE 439
+ + ++K+GDFGL L+ +R ++ GT Y++PE + Q +G E D+++LG ++
Sbjct: 193 ITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYT 252
Query: 440 LLHVCDT-AFETSKFFTDLR-----DGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 493
LL C + FET+ R + + LL +L P DRP+ +ILR
Sbjct: 253 LL--CGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILR 310
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 84.0 bits (206), Expect = 3e-16
Identities = 64/179 (35%), Positives = 93/179 (51%), Gaps = 13/179 (7%)
Query: 321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
+F+ ME+ G L +I K +LD+ + LF+QI GVDY H ++HRDLKP N+
Sbjct: 100 IFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVL 157
Query: 381 LVDTKQVKIGDFGLVTSLKNDGKRTR-SKGTLRYMSPEQISSQDY-GKEVDLYALGLILA 438
L KI DFGL +++ +DG+ R S G+ Y +PE IS + Y G EVD+++ G+IL
Sbjct: 158 LDAHMNAKIADFGL-SNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILY 216
Query: 439 ELLHVCDTA----FETSKFFTDLRDGII--SDIFDKKEKTLLQKLLSKKPEDRPNTSEI 491
LL C T F + DGI + +LL+ +L P R +I
Sbjct: 217 ALL--CGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDI 273
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 84.0 bits (206), Expect = 3e-16
Identities = 57/183 (31%), Positives = 90/183 (49%), Gaps = 17/183 (9%)
Query: 321 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 380
L+I ME+ G+ +E LD+ + +I KG+DY+HS+K IHRD+K +N+
Sbjct: 95 LWIIMEYLGGGSALDLLEPG---PLDETQIATILREILKGLDYLHSEKKIHRDIKAANVL 151
Query: 381 LVDTKQVKIGDFGLVTSLKNDG-KRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 439
L + +VK+ DFG+ L + KR GT +M+PE I Y + D+++LG+ E
Sbjct: 152 LSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIE 211
Query: 440 L---------LHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSE 490
L LH F K +G + K K ++ L+K+P RP E
Sbjct: 212 LARGEPPHSELHPMKVLFLIPKNNPPTLEG----NYSKPLKEFVEACLNKEPSFRPTAKE 267
Query: 491 ILR 493
+L+
Sbjct: 268 LLK 270
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,071,318
Number of Sequences: 37866
Number of extensions: 765379
Number of successful extensions: 4325
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 729
Number of HSP's successfully gapped in prelim test: 145
Number of HSP's that attempted gapping in prelim test: 2405
Number of HSP's gapped (non-prelim): 1205
length of query: 510
length of database: 18,247,518
effective HSP length: 107
effective length of query: 403
effective length of database: 14,195,856
effective search space: 5720929968
effective search space used: 5720929968
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.