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Search of human proteins with 20357552
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20357552 cortactin isoform a [Homo sapiens]
(550 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20357552 cortactin isoform a [Homo sapiens] 1125 0.0
gi|20357556 cortactin isoform b [Homo sapiens] 928 0.0
gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo s... 387 e-107
gi|62198235 drebrin-like isoform b [Homo sapiens] 103 5e-22
gi|21361670 drebrin-like isoform a [Homo sapiens] 102 7e-22
gi|171906575 drebrin-like isoform c [Homo sapiens] 100 5e-21
gi|5453710 LIM and SH3 protein 1 [Homo sapiens] 66 7e-11
gi|115527120 nebulin [Homo sapiens] 64 5e-10
gi|24308229 protein kinase C and casein kinase substrate in neur... 62 2e-09
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 61 2e-09
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 61 2e-09
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 61 2e-09
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 60 4e-09
gi|109689723 abl interactor 2 [Homo sapiens] 60 5e-09
gi|5453758 nebulette sarcomeric isoform [Homo sapiens] 59 1e-08
gi|47087157 nebulette non-muscle isoform [Homo sapiens] 59 1e-08
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 58 3e-08
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 58 3e-08
gi|61743948 abl-interactor 1 isoform d [Homo sapiens] 58 3e-08
gi|61743946 abl-interactor 1 isoform c [Homo sapiens] 58 3e-08
gi|61743944 abl-interactor 1 isoform b [Homo sapiens] 58 3e-08
gi|61743942 abl-interactor 1 isoform a [Homo sapiens] 58 3e-08
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 55 1e-07
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 55 2e-07
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 55 2e-07
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 55 2e-07
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 55 2e-07
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens] 55 2e-07
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 55 2e-07
gi|55956916 myosin IE [Homo sapiens] 55 2e-07
>gi|20357552 cortactin isoform a [Homo sapiens]
Length = 550
Score = 1125 bits (2910), Expect = 0.0
Identities = 550/550 (100%), Positives = 550/550 (100%)
Query: 1 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60
MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
Sbjct: 1 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60
Query: 61 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120
NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG
Sbjct: 61 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120
Query: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180
FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG
Sbjct: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180
Query: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT 240
KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT
Sbjct: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT 240
Query: 241 DRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQ 300
DRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQ
Sbjct: 241 DRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQ 300
Query: 301 DYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE 360
DYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE
Sbjct: 301 DYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE 360
Query: 361 KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV 420
KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV
Sbjct: 361 KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV 420
Query: 421 YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP 480
YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP
Sbjct: 421 YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP 480
Query: 481 AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL 540
AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL
Sbjct: 481 AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL 540
Query: 541 FPANYVELRQ 550
FPANYVELRQ
Sbjct: 541 FPANYVELRQ 550
>gi|20357556 cortactin isoform b [Homo sapiens]
Length = 513
Score = 928 bits (2398), Expect = 0.0
Identities = 458/550 (83%), Positives = 484/550 (88%), Gaps = 37/550 (6%)
Query: 1 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60
MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE
Sbjct: 1 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60
Query: 61 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120
NVFQEHQTLKEKELETGPKASHGYG
Sbjct: 61 NVFQEHQTLKEKELETGPKASHGYG----------------------------------- 85
Query: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180
GKFGV+ DR+D+SAVG EYQ K KH SQ D GFGGK+GVQ DRVD+SAVGF+YQG
Sbjct: 86 --GKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQG 143
Query: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT 240
KTEKH SQ+DYS GFGGKYG+ D+VDKSAVGF+YQGKTEKHESQ+DY KGFGGK+G+
Sbjct: 144 KTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQRDYSKGFGGKYGIDK 203
Query: 241 DRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQ 300
D+ DK A+G+++Q K + HESQKDY GFGGKFGVQ++RQD A+G+D++EKL HESQ+
Sbjct: 204 DKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQK 263
Query: 301 DYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE 360
DYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE
Sbjct: 264 DYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE 323
Query: 361 KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV 420
KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV
Sbjct: 324 KEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPV 383
Query: 421 YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP 480
YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP
Sbjct: 384 YEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYP 443
Query: 481 AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL 540
AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL
Sbjct: 444 AEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGL 503
Query: 541 FPANYVELRQ 550
FPANYVELRQ
Sbjct: 504 FPANYVELRQ 513
>gi|167234422 hematopoietic cell-specific Lyn substrate 1 [Homo
sapiens]
Length = 486
Score = 387 bits (993), Expect = e-107
Identities = 227/563 (40%), Positives = 306/563 (54%), Gaps = 94/563 (16%)
Query: 1 MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRE 60
MWK+ GH VS++ + G DDW+TDPDFVND+SEKEQRWGAKT++GSG EHINIH+LR
Sbjct: 1 MWKSVVGHDVSVSVETQG-DDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRN 59
Query: 61 NVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRG 120
V +EH L++KE+E+GPKASHGYG
Sbjct: 60 KVSEEHDVLRKKEMESGPKASHGYG----------------------------------- 84
Query: 121 FGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQG 180
G+FGV+ DR+D+SAVG EY + EKH+SQ D + GFGGKYGV+ DR DKSAVGFDY+G
Sbjct: 85 --GRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKG 142
Query: 181 KTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQT 240
+ EKH SQ+DYS+GFGG+YG++KDK DK+A+G++Y+G+TEKHESQ+DY KGFGG++G+Q
Sbjct: 143 EVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQK 202
Query: 241 DRQDKCALGWDHQE-KLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQ 299
DR DK A+G++ E ++ + G G++++ + A + K K + E
Sbjct: 203 DRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKAKFESMA----EEKRKREEEEKA 258
Query: 300 QDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAK 359
Q ++ Q++R + E V + + VP + K S+
Sbjct: 259 QQVARR-------QQERKAVTKRSPEAPQPVIAMEEPAVPA-PLPKKISSEAWPPVGTPP 310
Query: 360 EKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSP 419
E E R + E + RQ E + PP P ++ P
Sbjct: 311 SSESEPVRTSR-EHPVPLLPIRQTLPE-----------DNEEPPALPPRTLEGLQVEEEP 358
Query: 420 VYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHY 479
VYE P EPEP E + + Q+ E YE P
Sbjct: 359 VYEAEPE---------PEPEPEPEPENDYEDVEEMDRHEQED---EPEGDYEEVLEP--- 403
Query: 480 PAEDSTYDEY--------------ENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMI 525
EDS++ LGI+AVALYDYQ G DE+SFDPDD+IT+IEM+
Sbjct: 404 --EDSSFSSALAGSSGCPAGAGAGAVALGISAVALYDYQGEGSDELSFDPDDVITDIEMV 461
Query: 526 DDGWWRGVCKGRYGLFPANYVEL 548
D+GWWRG C G +GLFPANYV+L
Sbjct: 462 DEGWWRGRCHGHFGLFPANYVKL 484
>gi|62198235 drebrin-like isoform b [Homo sapiens]
Length = 430
Score = 103 bits (256), Expect = 5e-22
Identities = 93/307 (30%), Positives = 128/307 (41%), Gaps = 72/307 (23%)
Query: 303 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVTSKTSNIRANFENLAK 359
+K G Y K+ + F+DV V S YQKT V S+ + +
Sbjct: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAV----SEIKRVGKDSFWAKA 183
Query: 360 EKEQEDRR---KAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSP---------- 406
EKE+E+RR K AE AQR ++ + + E R + R + Q SP
Sbjct: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEV 243
Query: 407 -------------------------------APQPTEERLP------SSPVY----EDAA 425
+PQP + R P + P E AA
Sbjct: 244 VSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAA 303
Query: 426 SF---KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAE 482
+ +A+L P T P V + E A Y E Q+ V + H +
Sbjct: 304 AISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI--D 361
Query: 483 DSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV-CKGRYGLF 541
+ + G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG G +G+F
Sbjct: 362 HHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMF 421
Query: 542 PANYVEL 548
PANYVEL
Sbjct: 422 PANYVEL 428
>gi|21361670 drebrin-like isoform a [Homo sapiens]
Length = 431
Score = 102 bits (255), Expect = 7e-22
Identities = 93/308 (30%), Positives = 128/308 (41%), Gaps = 73/308 (23%)
Query: 303 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVTSKTSNIRANFENLAK 359
+K G Y K+ + F+DV V S YQKT V S+ + +
Sbjct: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAV----SEIKRVGKDSFWAKA 183
Query: 360 EKEQEDRR---KAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSP---------- 406
EKE+E+RR K AE AQR ++ + + E R + R + Q SP
Sbjct: 184 EKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQE 243
Query: 407 --------------------------------APQPTEERLP------SSPVY----EDA 424
+PQP + R P + P E A
Sbjct: 244 VVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPA 303
Query: 425 ASF---KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPA 481
A+ +A+L P T P V + E A Y E Q+ V + H
Sbjct: 304 AAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI-- 361
Query: 482 EDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGV-CKGRYGL 540
+ + + G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG G +G+
Sbjct: 362 DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGM 421
Query: 541 FPANYVEL 548
FPANYVEL
Sbjct: 422 FPANYVEL 429
>gi|171906575 drebrin-like isoform c [Homo sapiens]
Length = 439
Score = 100 bits (248), Expect = 5e-21
Identities = 97/317 (30%), Positives = 130/317 (41%), Gaps = 83/317 (26%)
Query: 303 SKGFGGKYGVQKDRMDKNASTFEDV---TQVSSAYQKTVPVEAVTSKTSNIRANFENLAK 359
+K G Y K+ + F+DV V S YQKT V S+ + +
Sbjct: 133 AKASGANYSFHKE-----SGRFQDVGPQAPVGSVYQKTNAV----SEIKRVGKDSFWAKA 183
Query: 360 EKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQAR----------------------- 396
EKE+E+RR E RA+ A+ + EQE R+L E AR
Sbjct: 184 EKEEENRRLEEKRRAEE-AQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQ 242
Query: 397 --------------AKTQTPPVSP-----------------APQPTEERLP------SSP 419
A Q V P +PQP + R P + P
Sbjct: 243 EVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQP 302
Query: 420 VY----EDAASF---KAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYES 472
E AA+ +A+L P T P V + E A Y E Q+ V +
Sbjct: 303 ETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQ 362
Query: 473 AEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRG 532
H + + + G+ A ALYDYQAA D EISFDP+++IT IE+ID+GWWRG
Sbjct: 363 GAGSEHI--DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG 420
Query: 533 V-CKGRYGLFPANYVEL 548
G +G+FPANYVEL
Sbjct: 421 YGPDGHFGMFPANYVEL 437
>gi|5453710 LIM and SH3 protein 1 [Homo sapiens]
Length = 261
Score = 66.2 bits (160), Expect = 7e-11
Identities = 57/203 (28%), Positives = 88/203 (43%), Gaps = 33/203 (16%)
Query: 369 AEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQ-----PTEERLPSSPVYED 423
A+ R+ ++ + Q + R K E + V+ P+ T++++ + +E+
Sbjct: 66 ADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEE 125
Query: 424 AASFKAELSYRGPVSGT--EPEPVYSMEAADYREASSQQGLAY--ATEAVYESAEAPGHY 479
E S GP G EPE S + + YR QQ + + VY+ P
Sbjct: 126 F-----EKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQPHHIPTSAPVYQQ---PQQQ 177
Query: 480 PAEDSTYDEYENDLGITAV-------------ALYDYQAAGDDEISFDPDDIITNIEMID 526
P S Y Y+ ++ A+YDY AA +DE+SF D I N++ ID
Sbjct: 178 PVAQS-YGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADEDEVSFQDGDTIVNVQQID 236
Query: 527 DGWWRGVCK--GRYGLFPANYVE 547
DGW G + G G+ PANYVE
Sbjct: 237 DGWMYGTVERTGDTGMLPANYVE 259
>gi|115527120 nebulin [Homo sapiens]
Length = 6669
Score = 63.5 bits (153), Expect = 5e-10
Identities = 42/123 (34%), Positives = 61/123 (49%), Gaps = 13/123 (10%)
Query: 437 VSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESA---EAPGHYPAEDSTYD------ 487
+SG E + +S EA D+ ++ G +A Y+ A E P + +T
Sbjct: 6546 ISGGEEKSEHS-EAPDHHLSTYSDGGVFAVSTAYKHAKTTELPQQRSSSVATQQTTVSSI 6604
Query: 488 -EYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCK--GRYGLFPAN 544
+ + G A+YDY AA DE+SF D I N++ ID+GW G + GR G+ PAN
Sbjct: 6605 PSHPSTAGKIFRAMYDYMAADADEVSFKDGDAIINVQAIDEGWMYGTVQRTGRTGMLPAN 6664
Query: 545 YVE 547
YVE
Sbjct: 6665 YVE 6667
>gi|24308229 protein kinase C and casein kinase substrate in neurons
1 [Homo sapiens]
Length = 444
Score = 61.6 bits (148), Expect = 2e-09
Identities = 71/265 (26%), Positives = 110/265 (41%), Gaps = 40/265 (15%)
Query: 313 QKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKA--- 369
QK DK +DV + Y+K + E V T N E + ++ +Q + ++
Sbjct: 188 QKKLQDKVDKCKQDVQKTQEKYEKVL--EDVGKTTPQYMENMEQVFEQCQQFEEKRLVFL 245
Query: 370 -----EAERAQRMAKERQEQEEARRKLEEQARA----------KTQTPPVSPAPQPTEER 414
+ +R +A E R+LE+ R ++ + P P P E
Sbjct: 246 KEVLLDIKRHLNLA-ENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEE 304
Query: 415 ----LPSSPVYEDAASFKAE----LSYRGPVSGTEPEPVYSMEAADYREASS-QQGLAYA 465
LP + ++ KAE + G V T +A D SS +G YA
Sbjct: 305 WNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTS-------QAGDRGSVSSYDRGQPYA 357
Query: 466 TEAVYESAEAPGHYPAEDSTYDEYENDL-GITAVALYDYQAAGDDEISFDPDDIITNI-E 523
TE + + P + + +E+D G+ ALYDY DE+SF D +T + E
Sbjct: 358 TEWSDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGE 417
Query: 524 MIDDGWWRG-VCKGRYGLFPANYVE 547
+ GW RG + G+ GL+PANYVE
Sbjct: 418 EDEQGWCRGRLDSGQLGLYPANYVE 442
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 61.2 bits (147), Expect = 2e-09
Identities = 26/57 (45%), Positives = 36/57 (63%)
Query: 494 GITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ 550
G A ALYD++ +DE+SF DIIT +E +DD W G G+ G+FP NY++ Q
Sbjct: 673 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 729
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/189 (24%), Positives = 79/189 (41%), Gaps = 11/189 (5%)
Query: 362 EQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVY 421
+Q + E ++ + + Q + L+E R++ P S A +P + P + V
Sbjct: 387 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDP--SHAQKPVDSGAPHAVVL 444
Query: 422 EDAASFKAELSYRGPVSGTEPEPVYSMEAAD---YREASSQQGLAYATEAVYESAEAPGH 478
D + + + ++ T E VY +E D YR Q + V + P
Sbjct: 445 HDFPAEQVD-----DLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEG 499
Query: 479 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 538
+ + G VA ++Y DE+SF +II E +++ W RG +GR
Sbjct: 500 GNGKRECVSSHCVK-GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRT 558
Query: 539 GLFPANYVE 547
G+FP N+VE
Sbjct: 559 GIFPLNFVE 567
Score = 51.6 bits (122), Expect = 2e-06
Identities = 21/52 (40%), Positives = 35/52 (67%)
Query: 497 AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVEL 548
AV L+D+ A D+++ +I+ +E ID W+RG C+ + G+FPANYV++
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKV 492
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 472 SAEAPGHYPAEDSTYDEYENDLGIT-AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWW 530
S + P EDS + N L AL+ + A D++SF D I +E +D W
Sbjct: 581 STKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWC 640
Query: 531 RGVCKGRYGLFPANYV 546
RG + R G+FPA +V
Sbjct: 641 RGRLQDREGIFPAVFV 656
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 61.2 bits (147), Expect = 2e-09
Identities = 26/57 (45%), Positives = 36/57 (63%)
Query: 494 GITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ 550
G A ALYD++ +DE+SF DIIT +E +DD W G G+ G+FP NY++ Q
Sbjct: 709 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 765
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/189 (24%), Positives = 79/189 (41%), Gaps = 11/189 (5%)
Query: 362 EQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVY 421
+Q + E ++ + + Q + L+E R++ P S A +P + P + V
Sbjct: 423 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDP--SHAQKPVDSGAPHAVVL 480
Query: 422 EDAASFKAELSYRGPVSGTEPEPVYSMEAAD---YREASSQQGLAYATEAVYESAEAPGH 478
D + + + ++ T E VY +E D YR Q + V + P
Sbjct: 481 HDFPAEQVD-----DLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEG 535
Query: 479 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 538
+ + G VA ++Y DE+SF +II E +++ W RG +GR
Sbjct: 536 GNGKRECVSSHCVK-GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRT 594
Query: 539 GLFPANYVE 547
G+FP N+VE
Sbjct: 595 GIFPLNFVE 603
Score = 51.6 bits (122), Expect = 2e-06
Identities = 21/52 (40%), Positives = 35/52 (67%)
Query: 497 AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVEL 548
AV L+D+ A D+++ +I+ +E ID W+RG C+ + G+FPANYV++
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKV 528
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 472 SAEAPGHYPAEDSTYDEYENDLGIT-AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWW 530
S + P EDS + N L AL+ + A D++SF D I +E +D W
Sbjct: 617 STKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWC 676
Query: 531 RGVCKGRYGLFPANYV 546
RG + R G+FPA +V
Sbjct: 677 RGRLQDREGIFPAVFV 692
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 61.2 bits (147), Expect = 2e-09
Identities = 26/57 (45%), Positives = 36/57 (63%)
Query: 494 GITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ 550
G A ALYD++ +DE+SF DIIT +E +DD W G G+ G+FP NY++ Q
Sbjct: 732 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQ 788
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/189 (24%), Positives = 79/189 (41%), Gaps = 11/189 (5%)
Query: 362 EQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVY 421
+Q + E ++ + + Q + L+E R++ P S A +P + P + V
Sbjct: 446 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDP--SHAQKPVDSGAPHAVVL 503
Query: 422 EDAASFKAELSYRGPVSGTEPEPVYSMEAAD---YREASSQQGLAYATEAVYESAEAPGH 478
D + + + ++ T E VY +E D YR Q + V + P
Sbjct: 504 HDFPAEQVD-----DLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEG 558
Query: 479 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 538
+ + G VA ++Y DE+SF +II E +++ W RG +GR
Sbjct: 559 GNGKRECVSSHCVK-GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRT 617
Query: 539 GLFPANYVE 547
G+FP N+VE
Sbjct: 618 GIFPLNFVE 626
Score = 51.6 bits (122), Expect = 2e-06
Identities = 21/52 (40%), Positives = 35/52 (67%)
Query: 497 AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVEL 548
AV L+D+ A D+++ +I+ +E ID W+RG C+ + G+FPANYV++
Sbjct: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKV 551
Score = 42.0 bits (97), Expect = 0.001
Identities = 26/76 (34%), Positives = 37/76 (48%), Gaps = 1/76 (1%)
Query: 472 SAEAPGHYPAEDSTYDEYENDLGIT-AVALYDYQAAGDDEISFDPDDIITNIEMIDDGWW 530
S + P EDS + N L AL+ + A D++SF D I +E +D W
Sbjct: 640 STKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWC 699
Query: 531 RGVCKGRYGLFPANYV 546
RG + R G+FPA +V
Sbjct: 700 RGRLQDREGIFPAVFV 715
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 60.5 bits (145), Expect = 4e-09
Identities = 26/52 (50%), Positives = 33/52 (63%)
Query: 495 ITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYV 546
+ A+ +DYQA DDE++ +IITNI D GWW G GR GLFP N+V
Sbjct: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFV 53
Score = 52.8 bits (125), Expect = 8e-07
Identities = 23/51 (45%), Positives = 33/51 (64%), Gaps = 2/51 (3%)
Query: 500 LYDYQAAGDDEISFDPDDIIT--NIEMIDDGWWRGVCKGRYGLFPANYVEL 548
++ Y+A DDE++ DI+T N + ID GWW G GR G+FP N+V+L
Sbjct: 275 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 325
Score = 48.9 bits (115), Expect = 1e-05
Identities = 17/47 (36%), Positives = 29/47 (61%)
Query: 501 YDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 547
+ Y DDE+ DII + +++GWW GV G+ G+FP+N+++
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153
>gi|109689723 abl interactor 2 [Homo sapiens]
Length = 475
Score = 60.1 bits (144), Expect = 5e-09
Identities = 50/153 (32%), Positives = 61/153 (39%), Gaps = 22/153 (14%)
Query: 403 PVSPAPQPTE--ERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAA------DYR 454
PVS AP P + P P+ A + +S P EPV+ DY
Sbjct: 330 PVSLAPPPPSILQVTPQLPLMGFVARVQENISDTPPPPPPVEEPVFDESPPPPPPPEDYE 389
Query: 455 EASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFD 514
E A Y A P +Y E VA+YDY +DE+SF
Sbjct: 390 EEE-------AAVVEYSDPYAEEDPPWAPRSYLE-------KVVAIYDYTKDKEDELSFQ 435
Query: 515 PDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 547
II I+ DDGW+ GV G GLFP NYVE
Sbjct: 436 EGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVE 468
>gi|5453758 nebulette sarcomeric isoform [Homo sapiens]
Length = 1014
Score = 58.9 bits (141), Expect = 1e-08
Identities = 35/95 (36%), Positives = 46/95 (48%), Gaps = 14/95 (14%)
Query: 455 EASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFD 514
+ S QG Y + S + H P TY A+YDY A +DE+SF
Sbjct: 929 QQSHSQGYGYMHQTSVSSMRSMQHSP-NLRTYR-----------AMYDYSAQDEDEVSFR 976
Query: 515 PDDIITNIEMIDDGWWRGVCK--GRYGLFPANYVE 547
D I N++ IDDGW G + GR G+ PANY+E
Sbjct: 977 DGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 1011
>gi|47087157 nebulette non-muscle isoform [Homo sapiens]
Length = 270
Score = 58.9 bits (141), Expect = 1e-08
Identities = 35/95 (36%), Positives = 46/95 (48%), Gaps = 14/95 (14%)
Query: 455 EASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFD 514
+ S QG Y + S + H P TY A+YDY A +DE+SF
Sbjct: 185 QQSHSQGYGYMHQTSVSSMRSMQHSP-NLRTYR-----------AMYDYSAQDEDEVSFR 232
Query: 515 PDDIITNIEMIDDGWWRGVCK--GRYGLFPANYVE 547
D I N++ IDDGW G + GR G+ PANY+E
Sbjct: 233 DGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIE 267
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 57.8 bits (138), Expect = 3e-08
Identities = 23/51 (45%), Positives = 33/51 (64%)
Query: 498 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVEL 548
+ +YDY A DDE++F+ II + D WW+G G+ GLFP+NYV+L
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/208 (28%), Positives = 86/208 (41%), Gaps = 22/208 (10%)
Query: 354 FENLAKE------KEQEDRRKA-EAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSP 406
F N KE K+Q ++K+ EAER ++ +ER+ E ++K E Q RA+ +
Sbjct: 603 FNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLE 662
Query: 407 APQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYAT 466
Q +E ++E+ +L V + E EA D Q A
Sbjct: 663 HVQQEDEHQRPRKLHEEE-----KLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAK 717
Query: 467 EAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDII-TNIEMI 525
AV P T EN + ALY +++ DEI+ P DI+ E +
Sbjct: 718 PAVQAPWSTAEKGPL---TISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774
Query: 526 DD------GWWRGVCKGRYGLFPANYVE 547
D+ GW G KG+ G FPANY E
Sbjct: 775 DESQTGEPGWLGGELKGKTGWFPANYAE 802
Score = 50.4 bits (119), Expect = 4e-06
Identities = 28/81 (34%), Positives = 46/81 (56%), Gaps = 3/81 (3%)
Query: 468 AVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDD 527
+ + A A G P+ + E G+ A ALY ++A D+ ++F+ +D+IT +E D
Sbjct: 891 SAFTPATATGSSPSP--VLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QD 947
Query: 528 GWWRGVCKGRYGLFPANYVEL 548
WW G +G+ G FP +YV+L
Sbjct: 948 MWWFGEVQGQKGWFPKSYVKL 968
Score = 43.5 bits (101), Expect = 5e-04
Identities = 17/52 (32%), Positives = 31/52 (59%), Gaps = 1/52 (1%)
Query: 498 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELR 549
+A+Y Y+++ +++F D+I + D WW G + G+FP+NYV L+
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVIL-VTKKDGDWWTGTVGDKAGVFPSNYVRLK 1058
Score = 38.1 bits (87), Expect = 0.021
Identities = 42/151 (27%), Positives = 64/151 (42%), Gaps = 24/151 (15%)
Query: 422 EDAASFK--AELSYRGPVSGTEPEPVYSMEAADYREASSQQGLA---------YATEAVY 470
E AS K A + + VSG E +Y+ E+++ + + QQG + T V
Sbjct: 985 ESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVG 1044
Query: 471 ESAEA-PGHY----PAEDSTYDEYENDLGIT---AVALYDYQAAGDDEISFDPDDIITNI 522
+ A P +Y +E S LG A + Y A G ++++ P +I
Sbjct: 1045 DKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIR 1104
Query: 523 EMIDDGWWRGVCKGR-----YGLFPANYVEL 548
+ GWW G + R G FPANYV+L
Sbjct: 1105 KKNPGGWWEGELQARGKKRQIGWFPANYVKL 1135
Score = 35.8 bits (81), Expect = 0.10
Identities = 25/74 (33%), Positives = 40/74 (54%), Gaps = 8/74 (10%)
Query: 335 QKTVPVEAVTSKTSNI-RANFE------NLAKEKEQEDRRKAEAERAQRMAKERQEQE-E 386
+K +PV K N R N E L +++ +E R A+ ERA++ KER+ QE E
Sbjct: 343 EKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQE 402
Query: 387 ARRKLEEQARAKTQ 400
+R+LE + + + Q
Sbjct: 403 RKRQLELEKQLEKQ 416
Score = 32.0 bits (71), Expect = 1.5
Identities = 19/51 (37%), Positives = 30/51 (58%), Gaps = 5/51 (9%)
Query: 355 ENLAKEKE-QEDRRKAEAERAQRMAK----ERQEQEEARRKLEEQARAKTQ 400
E KE+E QE RK + E +++ K ERQ +EE R+++E + AK +
Sbjct: 390 EQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRE 440
Score = 32.0 bits (71), Expect = 1.5
Identities = 15/38 (39%), Positives = 24/38 (63%)
Query: 357 LAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQ 394
L EK+ E +R+ E +R + KE + +E A+R+LE Q
Sbjct: 407 LELEKQLEKQRELERQREEERRKEIERREAAKRELERQ 444
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 57.8 bits (138), Expect = 3e-08
Identities = 23/51 (45%), Positives = 33/51 (64%)
Query: 498 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVEL 548
+ +YDY A DDE++F+ II + D WW+G G+ GLFP+NYV+L
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211
Score = 54.7 bits (130), Expect = 2e-07
Identities = 59/208 (28%), Positives = 86/208 (41%), Gaps = 22/208 (10%)
Query: 354 FENLAKE------KEQEDRRKA-EAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSP 406
F N KE K+Q ++K+ EAER ++ +ER+ E ++K E Q RA+ +
Sbjct: 603 FNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLE 662
Query: 407 APQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYAT 466
Q +E ++E+ +L V + E EA D Q A
Sbjct: 663 HVQQEDEHQRPRKLHEEE-----KLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAK 717
Query: 467 EAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDII-TNIEMI 525
AV P T EN + ALY +++ DEI+ P DI+ E +
Sbjct: 718 PAVQAPWSTAEKGPL---TISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774
Query: 526 DD------GWWRGVCKGRYGLFPANYVE 547
D+ GW G KG+ G FPANY E
Sbjct: 775 DESQTGEPGWLGGELKGKTGWFPANYAE 802
Score = 50.4 bits (119), Expect = 4e-06
Identities = 28/81 (34%), Positives = 46/81 (56%), Gaps = 3/81 (3%)
Query: 468 AVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDD 527
+ + A A G P+ + E G+ A ALY ++A D+ ++F+ +D+IT +E D
Sbjct: 891 SAFTPATATGSSPSP--VLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QD 947
Query: 528 GWWRGVCKGRYGLFPANYVEL 548
WW G +G+ G FP +YV+L
Sbjct: 948 MWWFGEVQGQKGWFPKSYVKL 968
Score = 43.5 bits (101), Expect = 5e-04
Identities = 17/52 (32%), Positives = 31/52 (59%), Gaps = 1/52 (1%)
Query: 498 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELR 549
+A+Y Y+++ +++F D+I + D WW G + G+FP+NYV L+
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVIL-VTKKDGDWWTGTVGDKAGVFPSNYVRLK 1058
Score = 38.1 bits (87), Expect = 0.021
Identities = 42/151 (27%), Positives = 64/151 (42%), Gaps = 24/151 (15%)
Query: 422 EDAASFK--AELSYRGPVSGTEPEPVYSMEAADYREASSQQGLA---------YATEAVY 470
E AS K A + + VSG E +Y+ E+++ + + QQG + T V
Sbjct: 985 ESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVG 1044
Query: 471 ESAEA-PGHY----PAEDSTYDEYENDLGIT---AVALYDYQAAGDDEISFDPDDIITNI 522
+ A P +Y +E S LG A + Y A G ++++ P +I
Sbjct: 1045 DKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIR 1104
Query: 523 EMIDDGWWRGVCKGR-----YGLFPANYVEL 548
+ GWW G + R G FPANYV+L
Sbjct: 1105 KKNPGGWWEGELQARGKKRQIGWFPANYVKL 1135
Score = 35.8 bits (81), Expect = 0.10
Identities = 25/74 (33%), Positives = 40/74 (54%), Gaps = 8/74 (10%)
Query: 335 QKTVPVEAVTSKTSNI-RANFE------NLAKEKEQEDRRKAEAERAQRMAKERQEQE-E 386
+K +PV K N R N E L +++ +E R A+ ERA++ KER+ QE E
Sbjct: 343 EKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQE 402
Query: 387 ARRKLEEQARAKTQ 400
+R+LE + + + Q
Sbjct: 403 RKRQLELEKQLEKQ 416
Score = 32.0 bits (71), Expect = 1.5
Identities = 19/51 (37%), Positives = 30/51 (58%), Gaps = 5/51 (9%)
Query: 355 ENLAKEKE-QEDRRKAEAERAQRMAK----ERQEQEEARRKLEEQARAKTQ 400
E KE+E QE RK + E +++ K ERQ +EE R+++E + AK +
Sbjct: 390 EQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRE 440
Score = 32.0 bits (71), Expect = 1.5
Identities = 15/38 (39%), Positives = 24/38 (63%)
Query: 357 LAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQ 394
L EK+ E +R+ E +R + KE + +E A+R+LE Q
Sbjct: 407 LELEKQLEKQRELERQREEERRKEIERREAAKRELERQ 444
>gi|61743948 abl-interactor 1 isoform d [Homo sapiens]
Length = 476
Score = 57.8 bits (138), Expect = 3e-08
Identities = 28/50 (56%), Positives = 32/50 (64%)
Query: 498 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 547
VA+YDY DDE+SF II I+ DDGW+ GVC GLFP NYVE
Sbjct: 420 VAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 469
>gi|61743946 abl-interactor 1 isoform c [Homo sapiens]
Length = 452
Score = 57.8 bits (138), Expect = 3e-08
Identities = 28/50 (56%), Positives = 32/50 (64%)
Query: 498 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 547
VA+YDY DDE+SF II I+ DDGW+ GVC GLFP NYVE
Sbjct: 396 VAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 445
>gi|61743944 abl-interactor 1 isoform b [Homo sapiens]
Length = 481
Score = 57.8 bits (138), Expect = 3e-08
Identities = 28/50 (56%), Positives = 32/50 (64%)
Query: 498 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 547
VA+YDY DDE+SF II I+ DDGW+ GVC GLFP NYVE
Sbjct: 425 VAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 474
>gi|61743942 abl-interactor 1 isoform a [Homo sapiens]
Length = 508
Score = 57.8 bits (138), Expect = 3e-08
Identities = 28/50 (56%), Positives = 32/50 (64%)
Query: 498 VALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 547
VA+YDY DDE+SF II I+ DDGW+ GVC GLFP NYVE
Sbjct: 452 VAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYVE 501
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 55.5 bits (132), Expect = 1e-07
Identities = 28/69 (40%), Positives = 38/69 (55%), Gaps = 2/69 (2%)
Query: 480 PAEDSTYDEYEN--DLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGR 537
PA+DS D E DL + A ++Y A +DE+S + +E DGWWRG G+
Sbjct: 92 PADDSFVDPGERLYDLNMPAYVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQ 151
Query: 538 YGLFPANYV 546
G FP+NYV
Sbjct: 152 VGWFPSNYV 160
Score = 39.3 bits (90), Expect = 0.009
Identities = 21/57 (36%), Positives = 33/57 (57%), Gaps = 7/57 (12%)
Query: 499 ALYDYQAAGDDEISFDPDDIITNIEM--IDDGWWRGVCK---GRYGLFPANYVELRQ 550
ALY + ++ D+E++F+ D++ IE D WW+ C+ G GL P NYV + Q
Sbjct: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWK--CRKINGMVGLVPKNYVTVMQ 251
Score = 29.6 bits (65), Expect = 7.5
Identities = 17/56 (30%), Positives = 28/56 (50%), Gaps = 6/56 (10%)
Query: 495 ITAVALYDYQAAGDDEISFDPDDIITNIEMIDDG--WWR-GVCKGRYGLFPANYVE 547
+ VA +DY A + E+ ++ + ++DD WWR + G P+NYVE
Sbjct: 5 VVVVAKFDYVAQQEQELDIKKNE---RLWLLDDSKSWWRVRNSMNKTGFVPSNYVE 57
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 55.1 bits (131), Expect = 2e-07
Identities = 59/239 (24%), Positives = 103/239 (43%), Gaps = 21/239 (8%)
Query: 324 FEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKE--------QEDRRKAEAERAQ 375
F DV + ++ P+ A T++ ++ +NL K+ + E R KA ++
Sbjct: 790 FRDVEDEETWIREKEPIAASTNRGKDL-IGVQNLLKKHQALQAEIAGHEPRIKAVTQKGN 848
Query: 376 RMAKERQ-EQEEARRKLEE-QARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSY 433
M +E E+ + KL E + + S Q E+ L + + DA ++ +
Sbjct: 849 AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
Query: 434 RGPVSGTEP--EPVYSMEAADYREASSQQGL-AYAT--EAVYESAEAPGHYPAEDSTYDE 488
+ P+ G+ + S EA + + L AY + +A+ E A++ A T DE
Sbjct: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP--TDDE 966
Query: 489 YENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 547
+L +ALYDYQ E++ DI+T + + WW+ R G PA YV+
Sbjct: 967 TGKEL---VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK 1022
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 55.1 bits (131), Expect = 2e-07
Identities = 59/239 (24%), Positives = 103/239 (43%), Gaps = 21/239 (8%)
Query: 324 FEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKE--------QEDRRKAEAERAQ 375
F DV + ++ P+ A T++ ++ +NL K+ + E R KA ++
Sbjct: 790 FRDVEDEETWIREKEPIAASTNRGKDL-IGVQNLLKKHQALQAEIAGHEPRIKAVTQKGN 848
Query: 376 RMAKERQ-EQEEARRKLEE-QARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSY 433
M +E E+ + KL E + + S Q E+ L + + DA ++ +
Sbjct: 849 AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
Query: 434 RGPVSGTEP--EPVYSMEAADYREASSQQGL-AYAT--EAVYESAEAPGHYPAEDSTYDE 488
+ P+ G+ + S EA + + L AY + +A+ E A++ A T DE
Sbjct: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP--TDDE 966
Query: 489 YENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVE 547
+L +ALYDYQ E++ DI+T + + WW+ R G PA YV+
Sbjct: 967 TGKEL---VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK 1022
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/68 (42%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 479 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 538
YPA S D DL I A + Y A +DE+S +T +E DGWWRG G+
Sbjct: 99 YPANGSGADRIY-DLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQI 157
Query: 539 GLFPANYV 546
G FP+NYV
Sbjct: 158 GWFPSNYV 165
Score = 32.3 bits (72), Expect = 1.2
Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 7/52 (13%)
Query: 500 LYDYQAAGDDEISFDPDDIITNIEMI--DDGWWRGVCK---GRYGLFPANYV 546
LY + + ++E++F+ + + IE D WW+ CK G+ GL P NYV
Sbjct: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWK--CKNARGQVGLVPKNYV 252
Score = 31.6 bits (70), Expect = 2.0
Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 6/56 (10%)
Query: 495 ITAVALYDYQAAGDDEISFDPDDIITNIEMIDDG--WWR-GVCKGRYGLFPANYVE 547
+ +A +DY A D E+ ++ + ++DD WWR R G P+NYVE
Sbjct: 5 VIVIAKWDYTAQQDQELDIKKNE---RLWLLDDSKTWWRVRNAANRTGYVPSNYVE 57
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/68 (42%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 479 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 538
YPA S D DL I A + Y A +DE+S +T +E DGWWRG G+
Sbjct: 99 YPANGSGADRIY-DLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQI 157
Query: 539 GLFPANYV 546
G FP+NYV
Sbjct: 158 GWFPSNYV 165
Score = 32.3 bits (72), Expect = 1.2
Identities = 18/52 (34%), Positives = 29/52 (55%), Gaps = 7/52 (13%)
Query: 500 LYDYQAAGDDEISFDPDDIITNIEMI--DDGWWRGVCK---GRYGLFPANYV 546
LY + + ++E++F+ + + IE D WW+ CK G+ GL P NYV
Sbjct: 203 LYPFSSVTEEELNFEKGETMEVIEKPENDPEWWK--CKNARGQVGLVPKNYV 252
Score = 31.6 bits (70), Expect = 2.0
Identities = 18/56 (32%), Positives = 28/56 (50%), Gaps = 6/56 (10%)
Query: 495 ITAVALYDYQAAGDDEISFDPDDIITNIEMIDDG--WWR-GVCKGRYGLFPANYVE 547
+ +A +DY A D E+ ++ + ++DD WWR R G P+NYVE
Sbjct: 5 VIVIAKWDYTAQQDQELDIKKNE---RLWLLDDSKTWWRVRNAANRTGYVPSNYVE 57
>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
Length = 540
Score = 55.1 bits (131), Expect = 2e-07
Identities = 25/68 (36%), Positives = 42/68 (61%), Gaps = 1/68 (1%)
Query: 479 YPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRY 538
YP+ S ++++ G A+YD++AA D+E++F +IIT ++ D WW+G
Sbjct: 198 YPSTSSLLTNHQHE-GRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGI 256
Query: 539 GLFPANYV 546
GLFP+N+V
Sbjct: 257 GLFPSNFV 264
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 55.1 bits (131), Expect = 2e-07
Identities = 35/94 (37%), Positives = 47/94 (50%), Gaps = 7/94 (7%)
Query: 460 QGLAYATEAVYESAE-APGHYPAEDSTYDEYENDLGITA-VALYDYQAAGDDEISFDPDD 517
+G A AT+ SA APG + ST G ALYDY+A G+DE+S
Sbjct: 4 RGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQ 63
Query: 518 IITNIEMI-----DDGWWRGVCKGRYGLFPANYV 546
++ + D+GWW G + R G+FPANYV
Sbjct: 64 LVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYV 97
Score = 29.3 bits (64), Expect = 9.8
Identities = 17/75 (22%), Positives = 35/75 (46%), Gaps = 1/75 (1%)
Query: 321 ASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKE-KEQEDRRKAEAERAQRMAK 379
A E +T + A +P E+ S + + + + E + +E ++ E R A
Sbjct: 392 ALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAAL 451
Query: 380 ERQEQEEARRKLEEQ 394
+++ QEE ++ E+Q
Sbjct: 452 QQKSQEELLKRREQQ 466
>gi|55956916 myosin IE [Homo sapiens]
Length = 1108
Score = 54.7 bits (130), Expect = 2e-07
Identities = 25/48 (52%), Positives = 31/48 (64%)
Query: 499 ALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYV 546
ALY Y A DE+SF+ +DII I+ GWW G +G+ GLFP NYV
Sbjct: 1058 ALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKQGLFPNNYV 1105
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.128 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,374,017
Number of Sequences: 37866
Number of extensions: 1053734
Number of successful extensions: 12722
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 416
Number of HSP's successfully gapped in prelim test: 567
Number of HSP's that attempted gapping in prelim test: 7050
Number of HSP's gapped (non-prelim): 4178
length of query: 550
length of database: 18,247,518
effective HSP length: 107
effective length of query: 443
effective length of database: 14,195,856
effective search space: 6288764208
effective search space used: 6288764208
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.