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Search of human proteins with 20336214
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20336214 glutaminase 2 [Homo sapiens]
(602 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20336214 glutaminase 2 [Homo sapiens] 1215 0.0
gi|156104878 glutaminase [Homo sapiens] 828 0.0
gi|118150656 ankyrin repeat domain 7 [Homo sapiens] 59 2e-08
gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens] 55 2e-07
gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens] 55 2e-07
gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens] 55 2e-07
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 54 4e-07
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 54 4e-07
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 51 3e-06
gi|122937331 60 kDa lysophospholipase [Homo sapiens] 51 3e-06
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 50 5e-06
gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens] 50 8e-06
gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens] 50 8e-06
gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens] 50 8e-06
gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens] 50 8e-06
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 49 1e-05
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 49 1e-05
gi|110431370 espin [Homo sapiens] 49 1e-05
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 49 1e-05
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 49 2e-05
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ... 49 2e-05
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni... 49 2e-05
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit... 49 2e-05
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 48 2e-05
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens] 48 2e-05
gi|34304383 Usher syndrome 1G protein [Homo sapiens] 48 2e-05
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 48 3e-05
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 47 4e-05
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 47 4e-05
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 47 5e-05
>gi|20336214 glutaminase 2 [Homo sapiens]
Length = 602
Score = 1215 bits (3143), Expect = 0.0
Identities = 602/602 (100%), Positives = 602/602 (100%)
Query: 1 MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQD 60
MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQD
Sbjct: 1 MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQD 60
Query: 61 HDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQ 120
HDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQ
Sbjct: 61 HDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQ 120
Query: 121 ESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVA 180
ESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVA
Sbjct: 121 ESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVA 180
Query: 181 AYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHK 240
AYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHK
Sbjct: 181 AYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHK 240
Query: 241 FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG 300
FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG
Sbjct: 241 FVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAG 300
Query: 301 NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG 360
NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG
Sbjct: 301 NEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESG 360
Query: 361 SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA 420
SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA
Sbjct: 361 SVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGA 420
Query: 421 ILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGA 480
ILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGA
Sbjct: 421 ILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGA 480
Query: 481 EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE 540
EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE
Sbjct: 481 EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE 540
Query: 541 ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES 600
ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES
Sbjct: 541 ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLES 600
Query: 601 MV 602
MV
Sbjct: 601 MV 602
>gi|156104878 glutaminase [Homo sapiens]
Length = 669
Score = 828 bits (2139), Expect = 0.0
Identities = 395/538 (73%), Positives = 458/538 (85%)
Query: 65 ESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSS 124
+ G+L L DLLFYTIAEGQE+IP+HKF TALK+TGL+TSDPRL++CM + +Q +S
Sbjct: 132 KQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSD 191
Query: 125 GGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIP 184
G +LD+DLF+KCV SNIVLLTQAFR+KFVIPDF FT H+D ++E K+ +GGKVA YIP
Sbjct: 192 GVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIP 251
Query: 185 QLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGK 244
QLAK +PDLWGVS+CTVDGQRHS G TK+PFCLQSCVKPL YAI+++ LGT+YVH++VGK
Sbjct: 252 QLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGK 311
Query: 245 EPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYM 304
EPSGLR+NKL LNE+ PHNPMVNAGAIVV+SLIK N AEKFD+V+Q+LNKMAGNEY+
Sbjct: 312 EPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYV 371
Query: 305 GFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMA 364
GFSNATFQSE+E+GDRN+AIGYYLKEKKCFP+G DM+ LD YFQLCS+EVTCES SVMA
Sbjct: 372 GFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMA 431
Query: 365 ATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLV 424
ATLANGG CPITGE VLS EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKS V+G ILLV
Sbjct: 432 ATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLV 491
Query: 425 VPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRN 484
VPNVMGMMC SPPLDK+GNS +G FC LVSL NFHNYDNLRH A+KLDPRREG + R
Sbjct: 492 VPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRV 551
Query: 485 KTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKV 544
K+V+NLLFAAY+GDVSALRRFALSAMDMEQ+DYDSRTALHVAAAEGH+EVVKFL+EACKV
Sbjct: 552 KSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKV 611
Query: 545 NPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV 602
NPF KDRW N P+D+A+ F H +V K+LQ+YQ YT +NL+ ++
Sbjct: 612 NPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL 669
>gi|118150656 ankyrin repeat domain 7 [Homo sapiens]
Length = 254
Score = 58.5 bits (140), Expect = 2e-08
Identities = 38/107 (35%), Positives = 57/107 (53%), Gaps = 4/107 (3%)
Query: 471 RKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFA-LSAMDMEQKDYDSRTALHVAAAE 529
RK + R +G +R K + L AA GD+ L+ + + D+ +D RT LH+A A
Sbjct: 10 RKNETRSQGYNLREKDLKKLHRAASVGDLKKLKEYLQIKKYDVNMQDKKYRTPLHLACAN 69
Query: 530 GHIEVVKFLIE-ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDY 575
GH +VV FLIE CK+N +D PL AVQ + + +L ++
Sbjct: 70 GHTDVVLFLIEQQCKIN--VRDSENKSPLIKAVQCQNEDCATILLNF 114
Score = 31.6 bits (70), Expect = 2.2
Identities = 30/93 (32%), Positives = 45/93 (48%), Gaps = 5/93 (5%)
Query: 481 EIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE 540
+IR TV++ +A +S + + D+E K+ D T L VA + ++VKFL+E
Sbjct: 122 DIRYNTVLH--YAVCGQSLSLVEKLLEYEADLEAKNKDGYTPLLVAVINNNPKMVKFLLE 179
Query: 541 -ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
VN A D + L AV +VKLL
Sbjct: 180 KGADVN--ASDNYQRTALILAVSGEPPCLVKLL 210
>gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens]
Length = 304
Score = 54.7 bits (130), Expect = 2e-07
Identities = 28/71 (39%), Positives = 39/71 (54%)
Query: 520 RTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSY 579
RT LH AA GH+E VK L++ C+ P +D G L DA+Q H++V +LL D +
Sbjct: 172 RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGAC 231
Query: 580 TLSETQAEAAA 590
+E A A
Sbjct: 232 LSAEDSLGAQA 242
Score = 34.3 bits (77), Expect = 0.34
Identities = 19/52 (36%), Positives = 28/52 (53%)
Query: 521 TALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
T LH AA GH +V+ +L EA ++ A +R PL +A H + V+ L
Sbjct: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYL 90
Score = 30.0 bits (66), Expect = 6.4
Identities = 21/67 (31%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 510 MDMEQKDYDSRTALHVAAAEGHIEVVKFLI-EACKVNPFAKDRWGNIPLDDAVQFNHLEV 568
MD+E + D + LH AA+ GH + V++L+ V+ K W PL A +L V
Sbjct: 62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADW--TPLMMACTRKNLGV 119
Query: 569 VKLLQDY 575
++ L ++
Sbjct: 120 IQELVEH 126
>gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 54.7 bits (130), Expect = 2e-07
Identities = 28/71 (39%), Positives = 39/71 (54%)
Query: 520 RTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSY 579
RT LH AA GH+E VK L++ C+ P +D G L DA+Q H++V +LL D +
Sbjct: 172 RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGAC 231
Query: 580 TLSETQAEAAA 590
+E A A
Sbjct: 232 LSAEDSLGAQA 242
Score = 37.7 bits (86), Expect = 0.031
Identities = 18/52 (34%), Positives = 29/52 (55%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEA 541
L +AA G S ++ D+ KD +R+ALH+A A H+ KFL+++
Sbjct: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQS 329
Score = 34.3 bits (77), Expect = 0.34
Identities = 19/52 (36%), Positives = 28/52 (53%)
Query: 521 TALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
T LH AA GH +V+ +L EA ++ A +R PL +A H + V+ L
Sbjct: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYL 90
Score = 30.0 bits (66), Expect = 6.4
Identities = 21/67 (31%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 510 MDMEQKDYDSRTALHVAAAEGHIEVVKFLI-EACKVNPFAKDRWGNIPLDDAVQFNHLEV 568
MD+E + D + LH AA+ GH + V++L+ V+ K W PL A +L V
Sbjct: 62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADW--TPLMMACTRKNLGV 119
Query: 569 VKLLQDY 575
++ L ++
Sbjct: 120 IQELVEH 126
Score = 30.0 bits (66), Expect = 6.4
Identities = 33/104 (31%), Positives = 47/104 (45%), Gaps = 15/104 (14%)
Query: 493 AAYSGDVSALRRFALSAMDMEQKDYDSR------TALHVAAAEGHIEVVKFLIE-ACKVN 545
AA +G A+R F +S + + D D R TALH AA EGH ++ L+ +N
Sbjct: 246 AAVTGQDEAIR-FLVSELGV---DVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADIN 301
Query: 546 PFAKDRWGNIPLDDAVQFNHLEVVKLL--QDYQDSYTLSETQAE 587
+KD L A HL K L +DS ++ T A+
Sbjct: 302 --SKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQ 343
>gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 54.7 bits (130), Expect = 2e-07
Identities = 28/71 (39%), Positives = 39/71 (54%)
Query: 520 RTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSY 579
RT LH AA GH+E VK L++ C+ P +D G L DA+Q H++V +LL D +
Sbjct: 172 RTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGAC 231
Query: 580 TLSETQAEAAA 590
+E A A
Sbjct: 232 LSAEDSLGAQA 242
Score = 37.7 bits (86), Expect = 0.031
Identities = 18/52 (34%), Positives = 29/52 (55%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEA 541
L +AA G S ++ D+ KD +R+ALH+A A H+ KFL+++
Sbjct: 278 LHYAAKEGHTSTIQTLLSLGADINSKDEKNRSALHLACAGQHLACAKFLLQS 329
Score = 34.3 bits (77), Expect = 0.34
Identities = 19/52 (36%), Positives = 28/52 (53%)
Query: 521 TALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
T LH AA GH +V+ +L EA ++ A +R PL +A H + V+ L
Sbjct: 39 TLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYL 90
Score = 30.0 bits (66), Expect = 6.4
Identities = 21/67 (31%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 510 MDMEQKDYDSRTALHVAAAEGHIEVVKFLI-EACKVNPFAKDRWGNIPLDDAVQFNHLEV 568
MD+E + D + LH AA+ GH + V++L+ V+ K W PL A +L V
Sbjct: 62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADW--TPLMMACTRKNLGV 119
Query: 569 VKLLQDY 575
++ L ++
Sbjct: 120 IQELVEH 126
Score = 30.0 bits (66), Expect = 6.4
Identities = 33/104 (31%), Positives = 47/104 (45%), Gaps = 15/104 (14%)
Query: 493 AAYSGDVSALRRFALSAMDMEQKDYDSR------TALHVAAAEGHIEVVKFLIE-ACKVN 545
AA +G A+R F +S + + D D R TALH AA EGH ++ L+ +N
Sbjct: 246 AAVTGQDEAIR-FLVSELGV---DVDVRATSTHLTALHYAAKEGHTSTIQTLLSLGADIN 301
Query: 546 PFAKDRWGNIPLDDAVQFNHLEVVKLL--QDYQDSYTLSETQAE 587
+KD L A HL K L +DS ++ T A+
Sbjct: 302 --SKDEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTLAQ 343
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 53.9 bits (128), Expect = 4e-07
Identities = 50/157 (31%), Positives = 73/157 (46%), Gaps = 22/157 (14%)
Query: 430 GMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEI--RNKTV 487
G+ S PL L + RG + V+ + Y L H A L+ ++ E+ RN +
Sbjct: 53 GLGSSSHPLSSLLSMWRGPN-----VNCVDSTGYTPLHHAA--LNGHKDVVEVLLRNDAL 105
Query: 488 VN---------LLFAAYSGDVSALRRF---ALSAMDMEQKDYDSRTALHVAAAEGHIEVV 535
N L AA+ GD +R S + +++ D+ TALH AA GH EVV
Sbjct: 106 TNVADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVV 165
Query: 536 KFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
K L+E +P ++ PLD A + LEVVK+L
Sbjct: 166 KVLLEEL-TDPTMRNNKFETPLDLAALYGRLEVVKML 201
Score = 30.0 bits (66), Expect = 6.4
Identities = 22/69 (31%), Positives = 33/69 (47%), Gaps = 6/69 (8%)
Query: 523 LHVAAAEGHIEVVKFLIEA----CKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDS 578
LH+AA +G ++V+ LI +VN D L A Q+ H EVVK+L +
Sbjct: 117 LHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDN--ETALHCAAQYGHTEVVKVLLEELTD 174
Query: 579 YTLSETQAE 587
T+ + E
Sbjct: 175 PTMRNNKFE 183
Score = 29.6 bits (65), Expect = 8.3
Identities = 23/89 (25%), Positives = 41/89 (46%), Gaps = 2/89 (2%)
Query: 484 NKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACK 543
NK L AA G + ++ + ++ + T LH+AA GH VV+ L++A
Sbjct: 180 NKFETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAARNGHKAVVQVLLDAGM 239
Query: 544 VNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
+ + + L +A F +VV++L
Sbjct: 240 DSNYQTEM--GSALHEAALFGKTDVVQIL 266
>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
Length = 319
Score = 53.9 bits (128), Expect = 4e-07
Identities = 34/100 (34%), Positives = 55/100 (55%), Gaps = 4/100 (4%)
Query: 479 GAEIRNKTVVN---LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVV 535
GA+I + ++ + +A+ G++ L+ + +D TALHVA GH E
Sbjct: 176 GAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECA 235
Query: 536 KFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDY 575
+ LI AC+ + AKDR G+ PL DAV+ N ++++LL Y
Sbjct: 236 EHLI-ACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
Score = 36.2 bits (82), Expect = 0.089
Identities = 27/86 (31%), Positives = 43/86 (50%), Gaps = 1/86 (1%)
Query: 487 VVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNP 546
V L AA + + +F + + D RTALH A EGH+ +V+ L+EA
Sbjct: 121 VPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIE 180
Query: 547 FAKDRWGNIPLDDAVQFNHLEVVKLL 572
F +D + + A + +L+V+KLL
Sbjct: 181 F-RDMLESTAIHWASRGGNLDVLKLL 205
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 51.2 bits (121), Expect = 3e-06
Identities = 41/119 (34%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 468 HCARKLDPRREGAEIR--NKTVVNLL-FAAYSGDVSALRRFALSAMDMEQKDYDSRTALH 524
H + LD + G +I N+ +N L A+ G V + +++ TALH
Sbjct: 53 HLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALH 112
Query: 525 VAAAEGHIEVVKFLI-EACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLS 582
+A+ G EVVK L+ VN A+ + G PL A Q NHLEVVK L D S +L+
Sbjct: 113 IASLAGQAEVVKVLVTNGANVN--AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLA 169
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Query: 483 RNKTVVNLLFAAYSGD-VSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEA 541
+ K ++ L A GD ++ ++ + ++ D TALHVAA GH +V K L++
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDK 389
Query: 542 CKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
K NP AK G PL A + N ++V++LL
Sbjct: 390 -KANPNAKALNGFTPLHIACKKNRIKVMELL 419
Score = 41.2 bits (95), Expect = 0.003
Identities = 30/104 (28%), Positives = 52/104 (50%), Gaps = 3/104 (2%)
Query: 471 RKLDPRREGAEIRNKTVVNLLF--AAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAA 528
+K R+ + + K+ N + AA +G + + + +D+ + + ALH+A+
Sbjct: 24 KKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASK 83
Query: 529 EGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
EGH+EVV L++ + N A + GN L A EVVK+L
Sbjct: 84 EGHVEVVSELLQR-EANVDAATKKGNTALHIASLAGQAEVVKVL 126
Score = 40.8 bits (94), Expect = 0.004
Identities = 26/83 (31%), Positives = 43/83 (51%), Gaps = 1/83 (1%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAK 549
L A+ +G ++ + ++ + + T L++AA E H+EVVKFL++ A
Sbjct: 111 LHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLAT 170
Query: 550 DRWGNIPLDDAVQFNHLEVVKLL 572
+ G PL A+Q H +VV LL
Sbjct: 171 ED-GFTPLAVALQQGHDQVVSLL 192
Score = 36.6 bits (83), Expect = 0.068
Identities = 25/86 (29%), Positives = 41/86 (47%), Gaps = 1/86 (1%)
Query: 487 VVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNP 546
+ L A+ G+ + ++ ++ K D T LH A GH +VV+ L++
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA-API 327
Query: 547 FAKDRWGNIPLDDAVQFNHLEVVKLL 572
+K + G PL A Q +HL V+LL
Sbjct: 328 LSKTKNGLSPLHMATQGDHLNCVQLL 353
Score = 36.6 bits (83), Expect = 0.068
Identities = 21/53 (39%), Positives = 31/53 (58%), Gaps = 3/53 (5%)
Query: 521 TALHVAAAEGHIEVVKFLIE-ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
T LHV G+I++V FL++ + KVN AK + G PL A Q H ++ +L
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVN--AKTKNGYTPLHQAAQQGHTHIINVL 782
Score = 35.8 bits (81), Expect = 0.12
Identities = 32/129 (24%), Positives = 54/129 (41%), Gaps = 6/129 (4%)
Query: 477 REGAEIRNKTVVNLL---FAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIE 533
+ GA I+ T L AA+ G V+ + + + TALH+AA G E
Sbjct: 421 KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480
Query: 534 VVKFLI-EACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEA 592
VV++L+ + +V AKD PL + + ++V+ L S + T
Sbjct: 481 VVRYLVQDGAQVEAKAKD--DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHL 538
Query: 593 LSKENLESM 601
++E E +
Sbjct: 539 SAREGHEDV 547
Score = 32.7 bits (73), Expect = 0.98
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 521 TALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQD 574
T LHVAA G +EV L++ +P A + G PL A +++ +V LL D
Sbjct: 567 TPLHVAAKYGKLEVANLLLQK-SASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619
Score = 31.2 bits (69), Expect = 2.9
Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 1/52 (1%)
Query: 521 TALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
T LH++A EGH +V FL++ + + G PL A ++ LEV LL
Sbjct: 534 TPLHLSAREGHEDVAAFLLDH-GASLSITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 29.6 bits (65), Expect = 8.3
Identities = 21/90 (23%), Positives = 41/90 (45%), Gaps = 14/90 (15%)
Query: 483 RNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEAC 542
+N+ + Y D +A+ R ++++ H+AA EGH+++V L+
Sbjct: 641 KNQMDIATTLLEYGADANAVTRQGIASV-------------HLAAQEGHVDMVSLLL-GR 686
Query: 543 KVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
N ++ G PL A Q + + V ++L
Sbjct: 687 NANVNLSNKSGLTPLHLAAQEDRVNVAEVL 716
>gi|122937331 60 kDa lysophospholipase [Homo sapiens]
Length = 579
Score = 51.2 bits (121), Expect = 3e-06
Identities = 41/120 (34%), Positives = 61/120 (50%), Gaps = 3/120 (2%)
Query: 473 LDPRREGAEIRNKTVVNLLFAA-YSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGH 531
L +E +RN V +L AA ++GDV AL+ D+ D++ +T LH AA GH
Sbjct: 387 LSGSQEADALRNALVPSLACAAAHAGDVEALQALVELGSDLGLVDFNGQTPLHAAARGGH 446
Query: 532 IEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAE 591
E V L++ V+ +D G PL AV+ H V+ LL++ S + E + EA E
Sbjct: 447 TEAVTMLLQR-GVDVNTRDTDGFSPLLLAVRGRHPGVIGLLREAGASLSTQELE-EAGTE 504
Score = 40.8 bits (94), Expect = 0.004
Identities = 42/162 (25%), Positives = 63/162 (38%), Gaps = 30/162 (18%)
Query: 384 EAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILL---VVPNVMGMMCLSPPLDK 440
EA++ + L G+ DF+GQ H + +LL V N SP L
Sbjct: 415 EALQALVELGSDLGLVDFNGQTPLHAAARGGHTEAVTMLLQRGVDVNTRDTDGFSPLLLA 474
Query: 441 LGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTV----VNLLFAAYS 496
+ H G ++ L R GA + + + L AY
Sbjct: 475 VRGRHPG------VIGLL-----------------REAGASLSTQELEEAGTELCRLAYR 511
Query: 497 GDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFL 538
D+ L+ + + D+ Q YD +ALHVA A G++ VV FL
Sbjct: 512 ADLEGLQVWWQAGADLGQPGYDGHSALHVAEAAGNLAVVAFL 553
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 50.4 bits (119), Expect = 5e-06
Identities = 26/83 (31%), Positives = 50/83 (60%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAK 549
L+ AA + + A++ + ++ KD + T LH+AA +GH EVV++L+ +++ +
Sbjct: 810 LMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQ 869
Query: 550 DRWGNIPLDDAVQFNHLEVVKLL 572
D G P+ A ++ H+++VKLL
Sbjct: 870 DDGGWTPMIWATEYKHVDLVKLL 892
Score = 43.1 bits (100), Expect = 7e-04
Identities = 25/86 (29%), Positives = 47/86 (54%), Gaps = 5/86 (5%)
Query: 490 LLFAAYSGDVSALRRFALSAMD--MEQKDYDSRTALHVAAAEGHIEVVKFLIEA-CKVNP 546
L F+A G++ + + +D + + + R+ LH AA GH+++ L++A ++
Sbjct: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
Query: 547 FAKDRWGNIPLDDAVQFNHLEVVKLL 572
++D+ PL +A + NHLE VK L
Sbjct: 802 CSEDQ--RTPLMEAAENNHLEAVKYL 825
Score = 39.7 bits (91), Expect = 0.008
Identities = 29/81 (35%), Positives = 41/81 (50%), Gaps = 3/81 (3%)
Query: 493 AAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEA-CKVNPFAKDR 551
AA +G V + +++ D RT L AA H+E VK+LI+A V+P KD
Sbjct: 780 AAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP--KDA 837
Query: 552 WGNIPLDDAVQFNHLEVVKLL 572
G+ L A + H EVV+ L
Sbjct: 838 EGSTCLHLAAKKGHYEVVQYL 858
Score = 29.6 bits (65), Expect = 8.3
Identities = 27/96 (28%), Positives = 45/96 (46%), Gaps = 7/96 (7%)
Query: 484 NKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIE-VVKFLIEAC 542
N+ + L +AA+SG V + D+ + + LH+AA E + VV FL
Sbjct: 904 NEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDS 963
Query: 543 KVNPFAKDRWGNIPLD----DAVQFNHLEVVKLLQD 574
V K++ G PL ++ ++ L++ K LQD
Sbjct: 964 DVT--LKNKEGETPLQCASLNSQVWSALQMSKALQD 997
>gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens]
Length = 1721
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/93 (34%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 511 DMEQKDYDSRTALHVAAAEGHIEVVKFLIE-ACKVNPFAKDRWGNIPLDDAVQFNHLEVV 569
D+ +D ALH A A G + +V+ L+E VN A+D G PL DAV+ +HLE+V
Sbjct: 1455 DVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQD--GTRPLHDAVENDHLEIV 1512
Query: 570 KLLQDYQDSYTLSETQAEAAAEALSKENLESMV 602
+LL Y TL+ + E +E +
Sbjct: 1513 RLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1545
>gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens]
Length = 1755
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/93 (34%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 511 DMEQKDYDSRTALHVAAAEGHIEVVKFLIE-ACKVNPFAKDRWGNIPLDDAVQFNHLEVV 569
D+ +D ALH A A G + +V+ L+E VN A+D G PL DAV+ +HLE+V
Sbjct: 1489 DVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQD--GTRPLHDAVENDHLEIV 1546
Query: 570 KLLQDYQDSYTLSETQAEAAAEALSKENLESMV 602
+LL Y TL+ + E +E +
Sbjct: 1547 RLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1579
>gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens]
Length = 1703
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/93 (34%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 511 DMEQKDYDSRTALHVAAAEGHIEVVKFLIE-ACKVNPFAKDRWGNIPLDDAVQFNHLEVV 569
D+ +D ALH A A G + +V+ L+E VN A+D G PL DAV+ +HLE+V
Sbjct: 1437 DVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQD--GTRPLHDAVENDHLEIV 1494
Query: 570 KLLQDYQDSYTLSETQAEAAAEALSKENLESMV 602
+LL Y TL+ + E +E +
Sbjct: 1495 RLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1527
>gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens]
Length = 1721
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/93 (34%), Positives = 47/93 (50%), Gaps = 3/93 (3%)
Query: 511 DMEQKDYDSRTALHVAAAEGHIEVVKFLIE-ACKVNPFAKDRWGNIPLDDAVQFNHLEVV 569
D+ +D ALH A A G + +V+ L+E VN A+D G PL DAV+ +HLE+V
Sbjct: 1455 DVNHRDNAGYCALHEACARGWLNIVRHLLEYGADVNCSAQD--GTRPLHDAVENDHLEIV 1512
Query: 570 KLLQDYQDSYTLSETQAEAAAEALSKENLESMV 602
+LL Y TL+ + E +E +
Sbjct: 1513 RLLLSYGADPTLATYSGRTIMKMTHSELMEKFL 1545
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 49.3 bits (116), Expect = 1e-05
Identities = 39/132 (29%), Positives = 59/132 (44%), Gaps = 9/132 (6%)
Query: 472 KLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGH 531
K++ R E E R L AA GD ++ D+ KD+ TALH A G+
Sbjct: 160 KVNKRNERGETR------LHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGY 213
Query: 532 IEVVKFLIEA-CKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAA 590
+V K L+ A +VN D + PL DA H +VVKLL Y + S + E
Sbjct: 214 YDVAKQLLAAGAEVNTKGLD--DDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPL 271
Query: 591 EALSKENLESMV 602
+ + + +++
Sbjct: 272 KVANSPTMVNLL 283
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 49.3 bits (116), Expect = 1e-05
Identities = 35/85 (41%), Positives = 48/85 (56%), Gaps = 4/85 (4%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTA--LHVAAAEGHIEVVKFLIEACKVNPF 547
LL A +GDVS ++R + A ++ KD R + LH AA G +VV+ L++ N
Sbjct: 186 LLEACRNGDVSRVKRL-VDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQM-GANVH 243
Query: 548 AKDRWGNIPLDDAVQFNHLEVVKLL 572
A+D G IPL +A F H EVV LL
Sbjct: 244 ARDDGGLIPLHNACSFGHAEVVSLL 268
Score = 47.0 bits (110), Expect = 5e-05
Identities = 33/109 (30%), Positives = 58/109 (53%), Gaps = 5/109 (4%)
Query: 478 EGAEIRNKTV-VNLLFAAYSGDVSALRRFALSAMDMEQKDYDSR--TALHVAAAEGHIEV 534
E IR V LL A+ +GD+ +++ S+ ++ +D + R T LH AA + V
Sbjct: 641 ESTPIRTSDVDYRLLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSV 699
Query: 535 VKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSE 583
V++L+ + AKD+ G +PL +A + H EV +LL + S +++
Sbjct: 700 VEYLLHH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVAD 747
Score = 41.6 bits (96), Expect = 0.002
Identities = 29/89 (32%), Positives = 51/89 (57%), Gaps = 6/89 (6%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSR--TALHVAAAEGHIEVVKFLIE-ACKVNP 546
LL AA G ++ +++ + ++ +D R T LH+AA ++EV ++L+E VN
Sbjct: 807 LLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN- 864
Query: 547 FAKDRWGNIPLDDAVQFNHLEVVKLLQDY 575
A+D+ G IPL +A + H+++ LL Y
Sbjct: 865 -AQDKGGLIPLHNAASYGHVDIAALLIKY 892
Score = 41.2 bits (95), Expect = 0.003
Identities = 35/113 (30%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSR--TALHVAAAEGHIEVVKFLIEACKVNPF 547
LL AA SG+ L L+ +++ D R T LH+AA + +V+ L++ +
Sbjct: 339 LLEAARSGNEEKLMAL-LTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQH-GADVH 396
Query: 548 AKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSET-QAEAAAEALSKENLE 599
AKD+ G +PL +A + H EV +LL + + Q EA SK +E
Sbjct: 397 AKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVE 449
Score = 37.7 bits (86), Expect = 0.031
Identities = 27/103 (26%), Positives = 45/103 (43%), Gaps = 3/103 (2%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACK-VNPFA 548
L FAA G + ++ +D LH A + GH EVV L+ C+ +P A
Sbjct: 220 LHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLL--CQGADPNA 277
Query: 549 KDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAE 591
+D W PL +A ++V +L + + T ++A +
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALD 320
Score = 37.7 bits (86), Expect = 0.031
Identities = 41/142 (28%), Positives = 62/142 (43%), Gaps = 28/142 (19%)
Query: 455 VSLFNF---HNYDNLRHCA-RKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAM 510
+ + NF +++ HCA L P+R K V LL LR+ A
Sbjct: 511 LEIINFKQPQSHETALHCAVASLHPKR-------KQVTELL----------LRKGA---- 549
Query: 511 DMEQKDYDSRTALHVAAAEGHIEVVKFLIE-ACKVNPFAKDRWGNIPLDDAVQFNHLEVV 569
++ +K+ D T LHVAA H +V++ L + K+N A D G L A HL+
Sbjct: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN--ALDTLGQTALHRAALAGHLQTC 607
Query: 570 KLLQDYQDSYTLSETQAEAAAE 591
+LL Y ++ Q AA+
Sbjct: 608 RLLLSYGSDPSIISLQGFTAAQ 629
Score = 33.1 bits (74), Expect = 0.75
Identities = 18/38 (47%), Positives = 24/38 (63%), Gaps = 1/38 (2%)
Query: 521 TALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLD 558
T LH AAA+G E+ K L++ +P K+R GN PLD
Sbjct: 752 TPLHEAAAKGKYEICKLLLKH-GADPTKKNRDGNTPLD 788
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 48.9 bits (115), Expect = 1e-05
Identities = 31/99 (31%), Positives = 49/99 (49%), Gaps = 2/99 (2%)
Query: 492 FAAYSGDVSALRRFALSAMD-MEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKD 550
+AA GD +LR + + + + T L++A EGH+EV ++L++ C +P A+
Sbjct: 144 YAAAKGDFPSLRLLVEHYPEGVNAQTKNGATPLYLACQEGHLEVTQYLVQECGADPHARA 203
Query: 551 RWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAA 589
G PL A Q H V+ L D +LSE + A
Sbjct: 204 HDGMTPLHAAAQMGHSPVIVWLVSCTD-VSLSEQDKDGA 241
Score = 43.9 bits (102), Expect = 4e-04
Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 2/63 (3%)
Query: 510 MDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVV 569
+ + ++D D TA+H AA+ GH +V+ +L+ + D WG PL DA + LE
Sbjct: 231 VSLSEQDKDGATAMHFAASRGHTKVLSWLL--LHGGEISADLWGGTPLHDAAENGELECC 288
Query: 570 KLL 572
++L
Sbjct: 289 QIL 291
Score = 35.4 bits (80), Expect = 0.15
Identities = 21/74 (28%), Positives = 36/74 (48%)
Query: 512 MEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKL 571
++ KD T LH+AA GH EVV +L+ +P A G +P+ A ++L
Sbjct: 97 VQDKDNSGATVLHLAARFGHPEVVNWLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRL 156
Query: 572 LQDYQDSYTLSETQ 585
L ++ ++T+
Sbjct: 157 LVEHYPEGVNAQTK 170
Score = 33.1 bits (74), Expect = 0.75
Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 1/83 (1%)
Query: 491 LFAAYSGDVSALRRF-ALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAK 549
L AA G++ LR A + +D +H AA G + ++FL+E + A+
Sbjct: 7 LQAARQGELDVLRSLHAAGLLGPSLRDPLDALPVHHAARAGKLHCLRFLVEEAALPAAAR 66
Query: 550 DRWGNIPLDDAVQFNHLEVVKLL 572
R G P DA HL ++ L
Sbjct: 67 ARNGATPAHDASATGHLACLQWL 89
Score = 32.7 bits (73), Expect = 0.98
Identities = 18/62 (29%), Positives = 29/62 (46%)
Query: 511 DMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVK 570
D + +D T LH AA GH V+ +L+ V+ +D+ G + A H +V+
Sbjct: 198 DPHARAHDGMTPLHAAAQMGHSPVIVWLVSCTDVSLSEQDKDGATAMHFAASRGHTKVLS 257
Query: 571 LL 572
L
Sbjct: 258 WL 259
Score = 31.6 bits (70), Expect = 2.2
Identities = 26/83 (31%), Positives = 40/83 (48%), Gaps = 5/83 (6%)
Query: 493 AAYSGDVSALRRFAL-SAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIE--ACKVNPFAK 549
AA +G + LR +A+ + + T H A+A GH+ +++L+ C+V K
Sbjct: 43 AARAGKLHCLRFLVEEAALPAAARARNGATPAHDASATGHLACLQWLLSQGGCRVQD--K 100
Query: 550 DRWGNIPLDDAVQFNHLEVVKLL 572
D G L A +F H EVV L
Sbjct: 101 DNSGATVLHLAARFGHPEVVNWL 123
Score = 30.4 bits (67), Expect = 4.9
Identities = 29/93 (31%), Positives = 39/93 (41%), Gaps = 13/93 (13%)
Query: 480 AEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLI 539
A + VVN L GD +A A DM +H AAA+G ++ L+
Sbjct: 112 ARFGHPEVVNWLLHHGGGDPTA-------ATDM------GALPIHYAAAKGDFPSLRLLV 158
Query: 540 EACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
E A+ + G PL A Q HLEV + L
Sbjct: 159 EHYPEGVNAQTKNGATPLYLACQEGHLEVTQYL 191
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 48.9 bits (115), Expect = 1e-05
Identities = 38/125 (30%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 476 RREGAEI--RNKTVVNLLF-AAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHI 532
RR+G++ RN LL A G + ++ + +DY T LH A GH+
Sbjct: 516 RRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHL 575
Query: 533 EVVKFLIE--ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAA 590
E+V+FL++ A +P + G PL DA+ H EV +LL + S TL + +
Sbjct: 576 EIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
Query: 591 EALSK 595
E L +
Sbjct: 636 ETLQQ 640
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 48.5 bits (114), Expect = 2e-05
Identities = 37/93 (39%), Positives = 49/93 (52%), Gaps = 7/93 (7%)
Query: 482 IRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQK-DYDSRTALHVAAAEGHIEVVKFLIE 540
+ N V NL AYSG + L+ L+ + + D DSRTALH A + GH E+V+FL++
Sbjct: 5 VSNLMVCNL---AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
Query: 541 -ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
VN KD G PL A E+VK L
Sbjct: 62 LGVPVND--KDDAGWSPLHIAASAGRDEIVKAL 92
Score = 35.4 bits (80), Expect = 0.15
Identities = 21/60 (35%), Positives = 34/60 (56%), Gaps = 1/60 (1%)
Query: 513 EQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
+ KD+ TA+H AAA+G+++++ L+ K + +D GN PL A +E KLL
Sbjct: 133 DAKDHYEATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191
Score = 33.5 bits (75), Expect = 0.58
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 2/80 (2%)
Query: 521 TALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYT 580
T LH AA++ E+ L+E NP AKD + + A +L+++ +L Y+ S
Sbjct: 108 TPLHYAASKNRHEIAVMLLEG-GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN 166
Query: 581 LSETQAEAAAE-ALSKENLE 599
+ +T+ A +E +E
Sbjct: 167 IQDTEGNTPLHLACDEERVE 186
Score = 33.1 bits (74), Expect = 0.75
Identities = 32/112 (28%), Positives = 52/112 (46%), Gaps = 4/112 (3%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLI-EACKVNPFA 548
L +A +G + + + KD + LH+AA+ G E+VK L+ + +VN A
Sbjct: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN--A 101
Query: 549 KDRWGNIPLDDAVQFNHLEV-VKLLQDYQDSYTLSETQAEAAAEALSKENLE 599
++ G PL A N E+ V LL+ + +A A A +K NL+
Sbjct: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLK 153
>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
sapiens]
Length = 151
Score = 48.5 bits (114), Expect = 2e-05
Identities = 37/93 (39%), Positives = 49/93 (52%), Gaps = 7/93 (7%)
Query: 482 IRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQK-DYDSRTALHVAAAEGHIEVVKFLIE 540
+ N V NL AYSG + L+ L+ + + D DSRTALH A + GH E+V+FL++
Sbjct: 5 VSNLMVCNL---AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
Query: 541 -ACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
VN KD G PL A E+VK L
Sbjct: 62 LGVPVND--KDDAGWSPLHIAASAGRDEIVKAL 92
Score = 30.8 bits (68), Expect = 3.7
Identities = 29/109 (26%), Positives = 48/109 (44%), Gaps = 9/109 (8%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLI-EACKVNPFA 548
L +A +G + + + KD + LH+AA+ G E+VK L+ + +VN A
Sbjct: 44 LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN--A 101
Query: 549 KDRWGNIPLDDAVQFNHLEVVKLL------QDYQDSYTLSETQAEAAAE 591
++ G PL A N E+ +L D +D Y + AA +
Sbjct: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKD 150
>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform b [Homo sapiens]
Length = 998
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/136 (23%), Positives = 62/136 (45%), Gaps = 1/136 (0%)
Query: 467 RHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVA 526
R R+ RR +R + L A SGD +R+ D+ + D TALH A
Sbjct: 39 RGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQA 98
Query: 527 AAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQA 586
+ ++++VKFL+E + N +D G PL A +L + + ++ S + ++
Sbjct: 99 CIDENLDMVKFLVEN-RANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEG 157
Query: 587 EAAAEALSKENLESMV 602
E ++ + ++ ++
Sbjct: 158 EVPSDLAEEPAMKDLL 173
Score = 34.7 bits (78), Expect = 0.26
Identities = 31/84 (36%), Positives = 43/84 (51%), Gaps = 8/84 (9%)
Query: 521 TALHVAAAEGHIEVVKFLIEA-CKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQ----DY 575
TALHVAAA+G+ EV++ LI+A ++N D W PL A + E +L D
Sbjct: 219 TALHVAAAKGYSEVLRLLIQAGYELNVQDYDGW--TPLHAAAHWGVKEACSILAEALCDM 276
Query: 576 QDSYTLSETQAEAAAEALSKENLE 599
L +T + A E L E+LE
Sbjct: 277 DIRNKLGQTPFDVADEGL-VEHLE 299
Score = 34.7 bits (78), Expect = 0.26
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 5/85 (5%)
Query: 493 AAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEA-CKVNPFAKDR 551
AA G LR + ++ +DYD T LH AA G E L EA C ++ +++
Sbjct: 224 AAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMD--IRNK 281
Query: 552 WGNIPLD--DAVQFNHLEVVKLLQD 574
G P D D HLE+++ Q+
Sbjct: 282 LGQTPFDVADEGLVEHLELLQKKQN 306
>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform a [Homo sapiens]
Length = 982
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/136 (23%), Positives = 62/136 (45%), Gaps = 1/136 (0%)
Query: 467 RHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVA 526
R R+ RR +R + L A SGD +R+ D+ + D TALH A
Sbjct: 39 RGAGRQPLTRRGSPRVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQA 98
Query: 527 AAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQA 586
+ ++++VKFL+E + N +D G PL A +L + + ++ S + ++
Sbjct: 99 CIDENLDMVKFLVEN-RANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEG 157
Query: 587 EAAAEALSKENLESMV 602
E ++ + ++ ++
Sbjct: 158 EVPSDLAEEPAMKDLL 173
Score = 34.7 bits (78), Expect = 0.26
Identities = 31/84 (36%), Positives = 43/84 (51%), Gaps = 8/84 (9%)
Query: 521 TALHVAAAEGHIEVVKFLIEA-CKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQ----DY 575
TALHVAAA+G+ EV++ LI+A ++N D W PL A + E +L D
Sbjct: 219 TALHVAAAKGYSEVLRLLIQAGYELNVQDYDGW--TPLHAAAHWGVKEACSILAEALCDM 276
Query: 576 QDSYTLSETQAEAAAEALSKENLE 599
L +T + A E L E+LE
Sbjct: 277 DIRNKLGQTPFDVADEGL-VEHLE 299
Score = 34.7 bits (78), Expect = 0.26
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 5/85 (5%)
Query: 493 AAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEA-CKVNPFAKDR 551
AA G LR + ++ +DYD T LH AA G E L EA C ++ +++
Sbjct: 224 AAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMD--IRNK 281
Query: 552 WGNIPLD--DAVQFNHLEVVKLLQD 574
G P D D HLE+++ Q+
Sbjct: 282 LGQTPFDVADEGLVEHLELLQKKQN 306
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/84 (35%), Positives = 43/84 (51%), Gaps = 3/84 (3%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLI-EACKVNPFA 548
L FAA +GD S+ R + + D++ RT +HVA G +V+ L+ V+
Sbjct: 508 LHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG 567
Query: 549 KDRWGNIPLDDAVQFNHLEVVKLL 572
KD W +PL A HL +VKLL
Sbjct: 568 KDAW--LPLHYAAWQGHLPIVKLL 589
Score = 40.8 bits (94), Expect = 0.004
Identities = 30/103 (29%), Positives = 46/103 (44%), Gaps = 4/103 (3%)
Query: 493 AAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRW 552
A G + +R +D+ + D+ LH AA +GH+ +VK L + V+ A+
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLD 603
Query: 553 GNIPLDDAVQFNHLEVVKLL----QDYQDSYTLSETQAEAAAE 591
G PL A Q H V ++L D L++T AAE
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAE 646
Score = 40.4 bits (93), Expect = 0.005
Identities = 28/83 (33%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 490 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAK 549
L AA +G ++ ++ D+ + ++TALH+AAA GH EVV+ L+ A ++ F
Sbjct: 674 LHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDLF-- 731
Query: 550 DRWGNIPLDDAVQFNHLEVVKLL 572
D G L A Q H + V+ L
Sbjct: 732 DEQGLSALHLAAQGRHAQTVETL 754
Score = 39.7 bits (91), Expect = 0.008
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 1/80 (1%)
Query: 493 AAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRW 552
AA +G S R E D TALH+AA GH+ VK L+E K + A+
Sbjct: 644 AAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE-KADVLARGPL 702
Query: 553 GNIPLDDAVQFNHLEVVKLL 572
L A H EVV+ L
Sbjct: 703 NQTALHLAAAHGHSEVVEEL 722
Score = 31.6 bits (70), Expect = 2.2
Identities = 39/128 (30%), Positives = 52/128 (40%), Gaps = 22/128 (17%)
Query: 447 GTSFCQKLVSLFNFH-NYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRF 505
G C K + L N + N N R P E R + VV LL A R+
Sbjct: 449 GQEECAKWLLLNNANPNLSNRRGST----PLHMAVERRVRGVVELLLA---------RKI 495
Query: 506 ALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEA-CKVNPFAKDRWGNIPLDDAVQFN 564
+++A KD D TALH AA G + L+E VN D G P+ A Q
Sbjct: 496 SVNA-----KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEV--DFEGRTPMHVACQHG 548
Query: 565 HLEVVKLL 572
+V++L
Sbjct: 549 QENIVRIL 556
Score = 29.6 bits (65), Expect = 8.3
Identities = 37/138 (26%), Positives = 52/138 (37%), Gaps = 8/138 (5%)
Query: 472 KLDPRREGAEIRNKTV---VNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAA 528
KL ++ G + +T+ L AA G R D+ ++T LHVAA
Sbjct: 587 KLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAE 646
Query: 529 EGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL----QDYQDSYTLSET 584
GH + L+ A G L A + HL VKLL D L++T
Sbjct: 647 TGHTSTARLLLHR-GAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQT 705
Query: 585 QAEAAAEALSKENLESMV 602
AA E +E +V
Sbjct: 706 ALHLAAAHGHSEVVEELV 723
>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
Length = 327
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/99 (31%), Positives = 50/99 (50%), Gaps = 1/99 (1%)
Query: 491 LFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKD 550
L AA G + + +F + D RTALH A+ EGH+E+++ L++ F +D
Sbjct: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDF-QD 211
Query: 551 RWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAA 589
R + A + HLEVVKLLQ + + + + + A
Sbjct: 212 RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTA 250
Score = 43.9 bits (102), Expect = 4e-04
Identities = 25/80 (31%), Positives = 45/80 (56%), Gaps = 1/80 (1%)
Query: 493 AAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRW 552
A+ G + L + + ++ +D TA+H A GH+EVVK L+++ + +D+
Sbjct: 188 ASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVK-LLQSHGADTNVRDKE 246
Query: 553 GNIPLDDAVQFNHLEVVKLL 572
G+ L DAV+ N +++KLL
Sbjct: 247 GDTALHDAVRLNRYKIIKLL 266
>gi|34304383 Usher syndrome 1G protein [Homo sapiens]
Length = 461
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/82 (34%), Positives = 44/82 (53%), Gaps = 1/82 (1%)
Query: 491 LFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKD 550
L+AAY G++ +LR D ++ D T LH+AA+ GH+ + FL+ + N + D
Sbjct: 37 LWAAYHGNLESLRLIVSRGGDPDKCDIWGNTPLHLAASNGHLHCLSFLV-SFGANIWCLD 95
Query: 551 RWGNIPLDDAVQFNHLEVVKLL 572
+ PLD A H+E V+ L
Sbjct: 96 NDYHTPLDMAAMKGHMECVRYL 117
Score = 30.0 bits (66), Expect = 6.4
Identities = 18/65 (27%), Positives = 29/65 (44%), Gaps = 1/65 (1%)
Query: 511 DMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVK 570
++ D D T AA G++E ++ ++ +P D WGN PL A HL +
Sbjct: 24 ELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGG-DPDKCDIWGNTPLHLAASNGHLHCLS 82
Query: 571 LLQDY 575
L +
Sbjct: 83 FLVSF 87
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 47.8 bits (112), Expect = 3e-05
Identities = 40/126 (31%), Positives = 62/126 (49%), Gaps = 8/126 (6%)
Query: 474 DPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIE 533
D +EGA ++ L+ A G +++ ++ D D TAL +A+ EGH E
Sbjct: 195 DVDQEGAN----SMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTE 250
Query: 534 VVKFLIEA-CKVNPFAKDRWGNIPLDDAVQFNHLEVVK-LLQDYQDSYTLSETQAEAAAE 591
+V+ L++A VN DR G+ L AV+ H+E+V+ LLQ Y D + A
Sbjct: 251 IVQDLLDAGTYVN--IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYW 308
Query: 592 ALSKEN 597
A+ K N
Sbjct: 309 AVEKGN 314
Score = 40.4 bits (93), Expect = 0.005
Identities = 31/117 (26%), Positives = 56/117 (47%), Gaps = 1/117 (0%)
Query: 456 SLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQK 515
S+ N+ +N+ L+ ++ E L+ AA G++ ++ + + +
Sbjct: 8 SVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLE 67
Query: 516 DYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLL 572
D D+ TAL A+ EGH+ +V+ L++ C VN +D G L A +VV+LL
Sbjct: 68 DLDNWTALISASKEGHVHIVEELLK-CGVNLEHRDMGGWTALMWACYKGRTDVVELL 123
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
sapiens]
Length = 823
Score = 47.4 bits (111), Expect = 4e-05
Identities = 46/154 (29%), Positives = 63/154 (40%), Gaps = 48/154 (31%)
Query: 479 GAEIRNKTVVNLLFAAYSGDVSALRR-FALSAMDMEQKDYDSRTALHVAAAEGHIEVVKF 537
G IR+ + + AA GD + + R A + D++ D RTALH+A A GH++VV
Sbjct: 26 GYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTL 85
Query: 538 LI-------------------------EACKV-------NPFAKDRWGNIPLDDAVQFNH 565
L+ EAC V NP KD +GN L AV
Sbjct: 86 LVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAV---- 141
Query: 566 LEVVKLLQDYQDSYTLSETQAEAAA--EALSKEN 597
Y +S +L+E A EAL K+N
Sbjct: 142 ---------YSESTSLAEKLLSHGAHIEALDKDN 166
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
sapiens]
Length = 823
Score = 47.4 bits (111), Expect = 4e-05
Identities = 46/154 (29%), Positives = 63/154 (40%), Gaps = 48/154 (31%)
Query: 479 GAEIRNKTVVNLLFAAYSGDVSALRR-FALSAMDMEQKDYDSRTALHVAAAEGHIEVVKF 537
G IR+ + + AA GD + + R A + D++ D RTALH+A A GH++VV
Sbjct: 26 GYRIRDSELQKIHRAAVKGDAAEVERCLARRSGDLDALDKQHRTALHLACASGHVQVVTL 85
Query: 538 LI-------------------------EACKV-------NPFAKDRWGNIPLDDAVQFNH 565
L+ EAC V NP KD +GN L AV
Sbjct: 86 LVNRKCQIDVCDKENRTPLIQAVHCQEEACAVILLEHGANPNLKDIYGNTALHYAV---- 141
Query: 566 LEVVKLLQDYQDSYTLSETQAEAAA--EALSKEN 597
Y +S +L+E A EAL K+N
Sbjct: 142 ---------YSESTSLAEKLLSHGAHIEALDKDN 166
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 47.0 bits (110), Expect = 5e-05
Identities = 30/85 (35%), Positives = 45/85 (52%), Gaps = 1/85 (1%)
Query: 491 LFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKD 550
L AA G + + +F + D RTALH A+ EGH+E+++ L++ F +D
Sbjct: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDF-QD 211
Query: 551 RWGNIPLDDAVQFNHLEVVKLLQDY 575
R + A + HLEVVKLLQ +
Sbjct: 212 RLDCTAMHWACRGGHLEVVKLLQSH 236
Score = 43.9 bits (102), Expect = 4e-04
Identities = 27/82 (32%), Positives = 43/82 (52%), Gaps = 3/82 (3%)
Query: 492 FAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVK-FLIEACKVNPFAKD 550
+A G + ++ D +D T LHVA G +E+V+ FL ++N A+D
Sbjct: 220 WACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEIN--ARD 277
Query: 551 RWGNIPLDDAVQFNHLEVVKLL 572
R G+ L DAV+ N +++KLL
Sbjct: 278 REGDTALHDAVRLNRYKIIKLL 299
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,518,838
Number of Sequences: 37866
Number of extensions: 939960
Number of successful extensions: 3679
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 178
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 2644
Number of HSP's gapped (non-prelim): 919
length of query: 602
length of database: 18,247,518
effective HSP length: 108
effective length of query: 494
effective length of database: 14,157,990
effective search space: 6994047060
effective search space used: 6994047060
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.