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Search of human proteins with 20270347
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
(300 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 602 e-172
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 83 3e-16
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 83 3e-16
gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens] 82 6e-16
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 81 1e-15
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 77 1e-14
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 77 1e-14
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 77 1e-14
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 77 1e-14
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 77 1e-14
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 77 1e-14
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 77 2e-14
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 77 2e-14
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 77 2e-14
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 77 2e-14
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 76 4e-14
gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Hom... 75 7e-14
gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo ... 75 7e-14
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 74 1e-13
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 74 2e-13
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 74 2e-13
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 73 3e-13
gi|38257146 ankyrin repeat domain 46 [Homo sapiens] 73 3e-13
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 73 3e-13
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 73 3e-13
gi|215820635 protein phosphatase 1, regulatory subunit 13 like [... 72 5e-13
gi|63003907 protein phosphatase 1, regulatory subunit 13 like [H... 72 5e-13
gi|38176283 ankyrin repeat and SOCS box-containing protein 7 iso... 71 1e-12
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 71 1e-12
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ... 71 1e-12
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 602 bits (1552), Expect = e-172
Identities = 300/300 (100%), Positives = 300/300 (100%)
Query: 1 MAAAAGDADDEPRSGHSSSEGECAVAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASGG 60
MAAAAGDADDEPRSGHSSSEGECAVAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASGG
Sbjct: 1 MAAAAGDADDEPRSGHSSSEGECAVAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASGG 60
Query: 61 AQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANA 120
AQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANA
Sbjct: 61 AQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANA 120
Query: 121 NDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPL 180
NDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPL
Sbjct: 121 NDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPL 180
Query: 181 HLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQ 240
HLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQ
Sbjct: 181 HLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQ 240
Query: 241 IIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVTDLLASFTSLSLQMQSMEKR 300
IIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVTDLLASFTSLSLQMQSMEKR
Sbjct: 241 IIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVTDLLASFTSLSLQMQSMEKR 300
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 82.8 bits (203), Expect = 3e-16
Identities = 73/206 (35%), Positives = 92/206 (44%), Gaps = 38/206 (18%)
Query: 46 LGGGGAGLSGR----ASGGAQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRL 101
L GGAGL G A+ G + LR+L L R AR R
Sbjct: 196 LAAGGAGLDGALLVAAAAGRGAALRFL----------------------LARGARVDAR- 232
Query: 102 GPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQL 161
G AL + D+E LL GADP D GR+ALH A+ G+ VQL
Sbjct: 233 --DGAGATALGLAAALGRSQDIEV---LLGHGADPGIRDRHGRSALHRAAARGHLLAVQL 287
Query: 162 LLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLN 221
L+ GA+ + RD LG TPLH A+ HV V LL GA+VDA +TPLHLA + +
Sbjct: 288 LVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGH 347
Query: 222 ------ILQEGHAQCLEAVRLEVKQI 241
+L G + L EV Q+
Sbjct: 348 GPTVGLLLSRGASPTLRTQWAEVAQM 373
Score = 64.3 bits (155), Expect = 1e-10
Identities = 40/95 (42%), Positives = 50/95 (52%), Gaps = 4/95 (4%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
V+ LL+ GA A D GRTALH A+ +G+ ++ +LLL GA R G G TPLH AA
Sbjct: 90 VRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAA 149
Query: 186 TNHVPVITTLLR----GGARVDALDRAGRTPLHLA 216
H + LL G A +A D G T H A
Sbjct: 150 LGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWA 184
Score = 62.8 bits (151), Expect = 4e-10
Identities = 40/91 (43%), Positives = 44/91 (48%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
V QLL GA D GRT LH A G+ +V+LLL GA D G T LH AA
Sbjct: 57 VTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAW 116
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
H V LL+ GA A G TPLH A
Sbjct: 117 HGHSRVAELLLQRGASAAARSGTGLTPLHWA 147
Score = 60.8 bits (146), Expect = 1e-09
Identities = 31/59 (52%), Positives = 37/59 (62%)
Query: 158 IVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
+V LL GA +RD G TPLHLA H P++ LL+ GA V A+DRAGRT LH A
Sbjct: 56 LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEA 114
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 82.8 bits (203), Expect = 3e-16
Identities = 51/126 (40%), Positives = 66/126 (52%), Gaps = 7/126 (5%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A+ V LL GA + D +GRT L AS GN ++V+ LLD G D N RD G
Sbjct: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRL 236
TPLH+AA H + L+ GAR + +D GR P LA QEGH C++ + L
Sbjct: 848 WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILAS------QEGHYDCVQ-ILL 900
Query: 237 EVKQII 242
E K I
Sbjct: 901 ENKSNI 906
Score = 72.0 bits (175), Expect = 6e-13
Identities = 43/118 (36%), Positives = 62/118 (52%)
Query: 105 GKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLD 164
G+ ++ L A+ V L++ GA+ D G T L A+ G+ +V LLL+
Sbjct: 710 GRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
Query: 165 HGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
GAD + D G TPL AA H V+ TLL GA VD++D GRT L +A ++ N+
Sbjct: 770 GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNV 827
Score = 71.6 bits (174), Expect = 8e-13
Identities = 48/124 (38%), Positives = 67/124 (54%), Gaps = 11/124 (8%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
LR +A + V LL+ GA+ AD++GRTAL A+ G+ +IV+ LLDHGA+ N D
Sbjct: 648 LRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHED 707
Query: 174 GLGNTPLHLA-----ACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHA 228
G T L +A A H V++ L+ GA VD D+ G TPL +A EGH
Sbjct: 708 VDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVA------AYEGHV 761
Query: 229 QCLE 232
++
Sbjct: 762 DVVD 765
Score = 65.1 bits (157), Expect = 7e-11
Identities = 39/106 (36%), Positives = 59/106 (55%), Gaps = 2/106 (1%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L+ +A V+ VQ L+E GA ++G TAL A+ G+ +VQ+LL+HGADPN D
Sbjct: 1016 LQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHAD 1075
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
G T + +AA H +I L + GA +L+ +P+H + K
Sbjct: 1076 QFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNGCSPSPVHTMEQK 1119
Score = 64.7 bits (156), Expect = 1e-10
Identities = 40/110 (36%), Positives = 63/110 (57%), Gaps = 6/110 (5%)
Query: 123 VETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHL 182
+E VQ L+ AD AAD++ R+AL A+ G+ ++VQLL++HGA + G T L +
Sbjct: 992 MEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCI 1051
Query: 183 AACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLE 232
AA H+ V+ LL GA + D+ GRT + +A + GH+Q ++
Sbjct: 1052 AAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVA------AKNGHSQIIK 1095
Score = 64.3 bits (155), Expect = 1e-10
Identities = 40/114 (35%), Positives = 60/114 (52%), Gaps = 6/114 (5%)
Query: 121 NDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPL 180
N + + LE+GA+ A+D +GRTALH + G+ ++VQ+L+ + AD N D + L
Sbjct: 957 NQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSAL 1016
Query: 181 HLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
AA HV V+ L+ GA VD G T L +A QEGH ++ +
Sbjct: 1017 QSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIA------AQEGHIDVVQVL 1064
Score = 63.9 bits (154), Expect = 2e-10
Identities = 42/103 (40%), Positives = 52/103 (50%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
LR +A E V LL G AD RTAL A+ G++ IV LL HGA+ N+ D
Sbjct: 615 LRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKAD 674
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G T L AA H ++ LL GA V+ D GRT L +A
Sbjct: 675 NEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
Score = 63.9 bits (154), Expect = 2e-10
Identities = 45/118 (38%), Positives = 59/118 (50%), Gaps = 6/118 (5%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A V+ V LLE GAD D+ GRT L A+ G+ +V LL GA + D G
Sbjct: 755 AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
T L +A+ +V V+ TLL G + D AG TPLH+A EGH EA+
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAF------EGHRLICEAL 866
Score = 63.5 bits (153), Expect = 2e-10
Identities = 36/93 (38%), Positives = 51/93 (54%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
+ VQ LLE+ ++ GR AL A+ G+ IV+LL HGAD N +D G L++
Sbjct: 894 DCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYIL 953
Query: 184 ACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
A N + + L GA V+A D GRT LH++
Sbjct: 954 ALENQLTMAEYFLENGANVEASDAEGRTALHVS 986
Score = 62.0 bits (149), Expect = 6e-10
Identities = 35/93 (37%), Positives = 52/93 (55%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
++++ LL++GA D GRT L A+ +G+ +V LL+ GAD D G+TPL LA
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 184 ACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
A H V+ L+ GA ++ D+ G T L A
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQDGWTALRSA 618
Score = 59.3 bits (142), Expect = 4e-09
Identities = 41/119 (34%), Positives = 57/119 (47%), Gaps = 6/119 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++A + ++ V L+ GAD D G T L A+ G+ ++V L+ GA+ N D
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTD 608
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA------KSKLNILQEG 226
G T L AA H V++ LL G +VD D RT L A LN+LQ G
Sbjct: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG 667
Score = 58.2 bits (139), Expect = 9e-09
Identities = 40/116 (34%), Positives = 54/116 (46%), Gaps = 7/116 (6%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
SA N VE V+ LL+ G D DD G T LH A+ G+ I + L++ GA N+ D G
Sbjct: 822 SAQGN-VEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLE 232
P LA+ H + LL + +D GR L +A EGH +E
Sbjct: 881 RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVA------ALEGHRDIVE 930
Score = 50.4 bits (119), Expect = 2e-06
Identities = 34/108 (31%), Positives = 49/108 (45%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
++ H L +A + V L+ GA+ D G TAL A+ G+ ++V LL
Sbjct: 574 EDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYA 633
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPL 213
G + D T L AA H ++ LL+ GA V+ D GRT L
Sbjct: 634 GVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681
Score = 47.8 bits (112), Expect = 1e-05
Identities = 29/89 (32%), Positives = 45/89 (50%)
Query: 127 QQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACT 186
+ L+E GA D+ GR AS G+ VQ+LL++ ++ +QR G L +AA
Sbjct: 864 EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALE 923
Query: 187 NHVPVITTLLRGGARVDALDRAGRTPLHL 215
H ++ L GA V+ D GR L++
Sbjct: 924 GHRDIVELLFSHGADVNCKDADGRPTLYI 952
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/103 (28%), Positives = 47/103 (45%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
LR +A + V+ L GAD D GR L+ + + + L++GA+ D
Sbjct: 917 LRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASD 976
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G T LH++ H+ ++ L+ A V+A D R+ L A
Sbjct: 977 AEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSA 1019
>gi|13129098 ankyrin repeat and SOCS box-containing 8 [Homo sapiens]
Length = 288
Score = 82.0 bits (201), Expect = 6e-16
Identities = 48/112 (42%), Positives = 67/112 (59%), Gaps = 1/112 (0%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
LK L + +D + V+ LLE GA+ A D RTALH+A+ ++ V++LL++GA+PN
Sbjct: 54 LKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAA-EKDEACVEVLLEYGANPN 112
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
DG +TPLH AA N+ + LL GA V+ALD TPL A K N+
Sbjct: 113 ALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNL 164
Score = 60.8 bits (146), Expect = 1e-09
Identities = 41/113 (36%), Positives = 59/113 (52%), Gaps = 4/113 (3%)
Query: 105 GKEVHALKRLRDSA----NANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQ 160
G EV+AL +A D V+ LLE GA+P A D T LH+A+ N + V+
Sbjct: 76 GAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVR 135
Query: 161 LLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPL 213
LL+ GA N D +TPL AA ++ ++ LL GA V ++ G+TP+
Sbjct: 136 ALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 188
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 81.3 bits (199), Expect = 1e-15
Identities = 54/156 (34%), Positives = 78/156 (50%), Gaps = 13/156 (8%)
Query: 79 RDELRCKIPAGRLRRAARPHRR--LGPTGKEVHALKRLRDSANANDVETVQQLLEDGADP 136
+ LR ++P + +P + + P G E+ +A N + + L DG DP
Sbjct: 83 KKRLRHRVPPRKPEPLVKPQSQAQVEPVGLEMFL-----KAAAENQEYLIDKYLTDGGDP 137
Query: 137 CAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLL 196
A D RTALH+A G+ Q+V LL GA + RD L TP+ A H+ ++ LL
Sbjct: 138 NAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLL 197
Query: 197 RGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLE 232
GARV+A D+ G TPLH+A ++ H CLE
Sbjct: 198 NQGARVNARDKIGSTPLHVA------VRTRHPDCLE 227
Score = 46.6 bits (109), Expect = 3e-05
Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 4/108 (3%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
++QLL GA A D G T LH A + ++ L++ GA N +D G+T LH A
Sbjct: 193 LKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEGDTALHEAVR 252
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEA 233
+ LL GA + + A TP+ LA+ Q G + L+A
Sbjct: 253 HGSYKAMKLLLLYGAELGVRNAASVTPVQLARD----WQRGIREALQA 296
Score = 40.0 bits (92), Expect = 0.003
Identities = 23/60 (38%), Positives = 37/60 (61%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
+ ++ L+E GA A D +G TALH A +G+ + ++LLL +GA+ R+ TP+ LA
Sbjct: 224 DCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLA 283
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 77.4 bits (189), Expect = 1e-14
Identities = 46/125 (36%), Positives = 67/125 (53%), Gaps = 5/125 (4%)
Query: 108 VHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGA 167
+H + L +A + + ++LL G D DD GRT LH A+ GN + + LLL+ GA
Sbjct: 370 IHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGA 429
Query: 168 DPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
D N++D G +PLH AA + + L+ GA V+ LD G TPLH A + +
Sbjct: 430 DFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAAT-----SDTD 484
Query: 228 AQCLE 232
+CLE
Sbjct: 485 GKCLE 489
Score = 73.9 bits (180), Expect = 2e-13
Identities = 45/113 (39%), Positives = 58/113 (51%), Gaps = 10/113 (8%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
+ V LL GA+ A D GRTALH + G+++ V LL HGA RD G TP+HL+
Sbjct: 667 DCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLS 726
Query: 184 ACTNHVPVITTLLRGGARVDA----LDRAGRTPLHLAKSKLNILQEGHAQCLE 232
A H+ V+ LL+ A +DA D G T LH A GH C+E
Sbjct: 727 AACGHIGVLGALLQSAASMDANPATADNHGYTALHWA------CYNGHETCVE 773
Score = 70.5 bits (171), Expect = 2e-12
Identities = 43/113 (38%), Positives = 62/113 (54%), Gaps = 1/113 (0%)
Query: 104 TGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLL 163
T K+ + L +A++ + V+ LL+ G D + G T LH A NG D +V L+
Sbjct: 200 TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI 259
Query: 164 DHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRG-GARVDALDRAGRTPLHL 215
D GA NQ++ G TPLH AA + H + LL G GA V+ + G+TPLH+
Sbjct: 260 DCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHM 312
Score = 69.7 bits (169), Expect = 3e-12
Identities = 42/116 (36%), Positives = 60/116 (51%), Gaps = 5/116 (4%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A +E V+ L+ GA+ D K T LH A+ +G +V+ LLD G D N+ + G
Sbjct: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLE 232
NTPLH+A V+ L+ GA V+ + G TPLH A + + A CLE
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTH-----GALCLE 290
Score = 68.6 bits (166), Expect = 7e-12
Identities = 42/103 (40%), Positives = 55/103 (53%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A D E ++ L+ GA A D K T LH A + +++ VQ+LL H AD N RD
Sbjct: 45 LHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARD 104
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
TPLH+AA V L+ + V+ DRAGRT LH A
Sbjct: 105 KNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 147
Score = 67.4 bits (163), Expect = 1e-11
Identities = 39/103 (37%), Positives = 60/103 (58%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A + E V+ LL GA+ A D K R A+H+A+ G+ ++V+LL+ HGA+ +D
Sbjct: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
TPLH AA + + V+ LL G ++ + G TPLH+A
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
Score = 62.4 bits (150), Expect = 5e-10
Identities = 33/80 (41%), Positives = 46/80 (57%)
Query: 139 ADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRG 198
+D GRTALH A+ +G+ ++V+LLL GA+ N D +H AA H+ V+ L+
Sbjct: 136 SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195
Query: 199 GARVDALDRAGRTPLHLAKS 218
GA V D+ TPLH A S
Sbjct: 196 GAEVTCKDKKSYTPLHAAAS 215
Score = 59.7 bits (143), Expect = 3e-09
Identities = 40/117 (34%), Positives = 55/117 (47%), Gaps = 34/117 (29%)
Query: 134 ADPCAADDKGRTALHFASCNGNDQIVQLLLDH---------------------------- 165
A+P AD+ G TALH+A NG++ V+LLL+
Sbjct: 747 ANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEM 806
Query: 166 -----GAD-PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
GA N D G TPLH AA T+HV + LL A+V+++D G+TPL +A
Sbjct: 807 LIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMA 863
Score = 58.5 bits (140), Expect = 7e-09
Identities = 41/131 (31%), Positives = 66/131 (50%), Gaps = 12/131 (9%)
Query: 110 ALKRLRDSANA------NDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLL 163
A +LRD + D + V+ L+ D D++ RT LH A+ G+ +I++LL+
Sbjct: 2 AFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61
Query: 164 DHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNIL 223
GA N +D TPLH A + + LL+ A V+A D+ +TPLH+A + +
Sbjct: 62 LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV- 120
Query: 224 QEGHAQCLEAV 234
+C EA+
Sbjct: 121 -----KCAEAL 126
Score = 58.2 bits (139), Expect = 9e-09
Identities = 37/104 (35%), Positives = 52/104 (50%), Gaps = 4/104 (3%)
Query: 117 SANANDVETVQQLLEDGADPCAA----DDKGRTALHFASCNGNDQIVQLLLDHGADPNQR 172
+A N +LL A+P A D G+T L + NG+ V LL+ GA+ + +
Sbjct: 623 AAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAK 682
Query: 173 DGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
D G T LH A T H + LL+ GA+ D GRTP+HL+
Sbjct: 683 DKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLS 726
Score = 56.6 bits (135), Expect = 3e-08
Identities = 34/96 (35%), Positives = 48/96 (50%)
Query: 127 QQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACT 186
Q +++ GA D G T LH A+ G++ ++ L+ GAD +R G PLHLAA +
Sbjct: 323 QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALS 382
Query: 187 NHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
LL G +D D GRT LH A + N+
Sbjct: 383 GFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNL 418
Score = 56.6 bits (135), Expect = 3e-08
Identities = 36/109 (33%), Positives = 50/109 (45%), Gaps = 6/109 (5%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
+ L+ GAD G LH A+ +G + LL G D + D G T LH AA
Sbjct: 355 INTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAA 414
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
++ + LL GA + D+ GR+PLH A + N QCL A+
Sbjct: 415 GGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNY------QCLFAL 457
Score = 55.8 bits (133), Expect = 4e-08
Identities = 34/100 (34%), Positives = 50/100 (50%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A+ + ++ L+ +GAD G+T LH + +G Q ++ GA + D G
Sbjct: 280 AASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNG 339
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
NTPLH+AA H +I TL+ GA G PLHLA
Sbjct: 340 NTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLA 379
Score = 55.8 bits (133), Expect = 4e-08
Identities = 40/103 (38%), Positives = 51/103 (49%), Gaps = 4/103 (3%)
Query: 121 NDVETVQQLLED--GADPC-AADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGN 177
ND E ++L D GA A D KGRT LH A+ + + +QLLL H A N D G
Sbjct: 798 NDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGK 857
Query: 178 TPLHLAACTNHVPVITTLL-RGGARVDALDRAGRTPLHLAKSK 219
TPL +AA + L+ A + D + T LHLA SK
Sbjct: 858 TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
Score = 55.5 bits (132), Expect = 6e-08
Identities = 33/93 (35%), Positives = 48/93 (51%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
E VQ LL+ AD A D +T LH A+ N + + L+ ++ N D G T LH A
Sbjct: 88 EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 147
Query: 184 ACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
A + H ++ LL GA ++A D+ R +H A
Sbjct: 148 AFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA 180
Score = 53.1 bits (126), Expect = 3e-07
Identities = 45/168 (26%), Positives = 81/168 (48%), Gaps = 21/168 (12%)
Query: 122 DVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL-----LDHGADPNQRDGLG 176
D + ++ LL + A+P D +G A+H+++ G+ +QL+ LD + + D L
Sbjct: 484 DGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLS 543
Query: 177 N-------TPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQ 229
+ +PLHLAA H + L++ +D + +GRTPL LA K GH +
Sbjct: 544 DSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFK------GHVE 597
Query: 230 CLEAVRLEVKQIIHMLREY-LERLGQHEQRERLDDLCTRLQMTSTKEQ 276
C++ + + I ++++Y L+R H C RL + + + Q
Sbjct: 598 CVDVLINQGASI--LVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQ 643
Score = 46.2 bits (108), Expect = 3e-05
Identities = 34/107 (31%), Positives = 52/107 (48%), Gaps = 4/107 (3%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH-GADPNQR 172
L +A + VE +Q LL A + D G+T L A+ NG V++L+ A+ +
Sbjct: 827 LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQ 886
Query: 173 DGLGNTPLHLAACTNH---VPVITTLLRGGARVDALDRAGRTPLHLA 216
D NT LHLA H +I + ++A + A +TPLH+A
Sbjct: 887 DNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVA 933
Score = 45.1 bits (105), Expect = 8e-05
Identities = 33/100 (33%), Positives = 46/100 (46%), Gaps = 4/100 (4%)
Query: 117 SANANDVETVQQLLEDG-ADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGL 175
+A TV+ L+ A+ D+ TALH A G++ L+L+ D N +
Sbjct: 863 AAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINAT 922
Query: 176 G---NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTP 212
TPLH+AA V+ LL GA V A+D G TP
Sbjct: 923 NAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
Score = 44.3 bits (103), Expect = 1e-04
Identities = 38/113 (33%), Positives = 55/113 (48%), Gaps = 12/113 (10%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDG-LGNTPLHL 182
+ ++ L++ D + GRT L A+ G+ + V +L++ GA +D L TP+H
Sbjct: 564 QALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHA 623
Query: 183 AACTNHVPVITTLLRGGAR----VDALDRAGRTPLHLAKSKLNILQEGHAQCL 231
AA H + LL G A VD D G+TPL L S LN GH C+
Sbjct: 624 AATNGHSECL-RLLIGNAEPQNAVDIQDGNGQTPLML--SVLN----GHTDCV 669
Score = 44.3 bits (103), Expect = 1e-04
Identities = 53/215 (24%), Positives = 75/215 (34%), Gaps = 63/215 (29%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGA----DPNQRDGLGNTP 179
E V LL+ GA D +GRT +H ++ G+ ++ LL A +P D G T
Sbjct: 700 ECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTA 759
Query: 180 LHLAACTNHVPVITTLLR----------------------------------GGARVDAL 205
LH A H + LL G + V+A
Sbjct: 760 LHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNAT 819
Query: 206 DRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQIIHMLREYLERLGQHEQRERLDDL- 264
D GRTPLH A H +CL+ + L + Q +D
Sbjct: 820 DSKGRTPLHAAAF------TDHVECLQLL-----------------LSHNAQVNSVDSTG 856
Query: 265 CTRLQMTSTKEQVDEVTDLLASFTSLSLQMQSMEK 299
T L M + Q + V ++L S S L +Q K
Sbjct: 857 KTPLMMAAENGQTNTV-EMLVSSASAELTLQDNSK 890
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 77.4 bits (189), Expect = 1e-14
Identities = 46/109 (42%), Positives = 59/109 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A N VE + LL+ G A +G T LH A+ G+ ++V LLL A+ N +
Sbjct: 639 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN 698
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
G TPLHL A HVPV L++ G VDA R G TPLH+A NI
Sbjct: 699 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 747
Score = 75.5 bits (184), Expect = 5e-14
Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 8/145 (5%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
K + L + +A + ++ V+ LL+ A+ T LH A+ G+ ++ ++LLD
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK------ 219
GA PN R G TPLH+A NHV V+ LL+ GA +DA+ +G TPLH+A
Sbjct: 394 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
Query: 220 LNILQEGHAQCLEAVRLEVKQIIHM 244
N+LQ G + + V++E +HM
Sbjct: 454 KNLLQRGASPNVSNVKVETP--LHM 476
Score = 73.2 bits (178), Expect = 3e-13
Identities = 49/116 (42%), Positives = 59/116 (50%), Gaps = 6/116 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A V + LLE A P AA G T LH A + N IV+LLL G P+
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 632
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQ 229
G TPLH+AA N V V +LL+ G +A G TPLHLA QEGHA+
Sbjct: 633 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA------AQEGHAE 682
Score = 70.1 bits (170), Expect = 2e-12
Identities = 42/114 (36%), Positives = 59/114 (51%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + ++ L + N V ++ LL+ GA A + G T LH AS G+ IV+ L
Sbjct: 397 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 456
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
L GA PN + TPLH+AA H V LL+ A+V+A + +TPLH A
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 510
Score = 67.8 bits (164), Expect = 1e-11
Identities = 39/100 (39%), Positives = 52/100 (52%)
Query: 118 ANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGN 177
A V L++ G A G T LH AS GN ++V+ LL H AD N + LG
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768
Query: 178 TPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
+PLH AA H ++T LL+ GA + + G TPL +AK
Sbjct: 769 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808
Score = 67.4 bits (163), Expect = 1e-11
Identities = 42/119 (35%), Positives = 63/119 (52%), Gaps = 6/119 (5%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
+ L L ++ V+ V +LL KG TALH A+ G D++V+ L+++GA+
Sbjct: 77 NGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 136
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
N + G TPL++AA NH+ V+ LL GA + G TPL +A LQ+GH
Sbjct: 137 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA------LQQGH 189
Score = 66.6 bits (161), Expect = 3e-11
Identities = 41/118 (34%), Positives = 59/118 (50%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
R P V L +A A E + LL++ A A +T LH A+ G+ +
Sbjct: 459 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 518
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
V+LLL++ A+PN G+TPLH+AA HV + LL A + + G TPLH+A
Sbjct: 519 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 576
Score = 64.3 bits (155), Expect = 1e-10
Identities = 51/171 (29%), Positives = 78/171 (45%), Gaps = 9/171 (5%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A +D T LL++ +P G T LH A+ N + QLLL+ GA N
Sbjct: 207 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 266
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQC 230
G TPLH+A+ +V ++ LL GA+++ + TPLH A + GH +
Sbjct: 267 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA------ARNGHVRI 320
Query: 231 LEAVRLEVKQIIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVT 281
E + I + L + Q + LD C RL + E +D++T
Sbjct: 321 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD--CVRLLLQYDAE-IDDIT 368
Score = 63.9 bits (154), Expect = 2e-10
Identities = 40/125 (32%), Positives = 60/125 (48%), Gaps = 6/125 (4%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + L L + + N+++ V+ LL G P + G T LH A+ ++ + L
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
L +G N G TPLHLAA H ++ LL A + +++G TPLHL +
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL------V 708
Query: 223 LQEGH 227
QEGH
Sbjct: 709 AQEGH 713
Score = 63.5 bits (153), Expect = 2e-10
Identities = 44/128 (34%), Positives = 63/128 (49%), Gaps = 6/128 (4%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A VETV LLE A KG T LH A+ G ++ +LLL+ A PN
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 599
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK------LNILQEGH 227
G TPLH+A N++ ++ LL G + G TPLH+A + ++LQ G
Sbjct: 600 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659
Query: 228 AQCLEAVR 235
+ E+V+
Sbjct: 660 SANAESVQ 667
Score = 62.0 bits (149), Expect = 6e-10
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 6/109 (5%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
V+ LL+ GA P ++ K T LH A+ G+ ++ + LL + A N + TPLH AA
Sbjct: 453 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 512
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
H ++ LL A + AG TPLH+A +EGH + + A+
Sbjct: 513 IGHTNMVKLLLENNANPNLATTAGHTPLHIA------AREGHVETVLAL 555
Score = 58.2 bits (139), Expect = 9e-09
Identities = 35/106 (33%), Positives = 55/106 (51%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A+ + LL+ GA P + G T LH A + ++++LLL GA +
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH+A+ H+P++ LL+ GA + + TPLH+A
Sbjct: 432 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 477
Score = 57.8 bits (138), Expect = 1e-08
Identities = 35/103 (33%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ +V V+ LL+ GA T LH A+ NG+ +I ++LLDHGA +
Sbjct: 276 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 335
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G +P+H+AA +H+ + LL+ A +D + TPLH+A
Sbjct: 336 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 378
Score = 56.6 bits (135), Expect = 3e-08
Identities = 39/109 (35%), Positives = 52/109 (47%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A V+ LLE+ A+P A G T LH A+ G+ + V LL+ A
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
G TPLH+AA V V LL A +A + G TPLH+A N+
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 615
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 6/122 (4%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
+ V + L +A E V LL A+ + G T LH + G+ + +L+ H
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQE 225
G + +G TPLH+A+ ++ ++ LL+ A V+A + G +PLH A Q+
Sbjct: 724 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA------AQQ 777
Query: 226 GH 227
GH
Sbjct: 778 GH 779
Score = 48.9 bits (115), Expect = 5e-06
Identities = 40/142 (28%), Positives = 60/142 (42%), Gaps = 31/142 (21%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A A E V++L+ GA+ A KG T L+ A+ + ++V+ LL++GA+ N
Sbjct: 115 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 174
Query: 174 GLGNTP-----------------------------LHLAACTNHVPVITTLLRGGARVDA 204
G TP LH+AA + LL+ D
Sbjct: 175 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 234
Query: 205 LDRAGRTPLHLAK--SKLNILQ 224
L + G TPLH+A LN+ Q
Sbjct: 235 LSKTGFTPLHIAAHYENLNVAQ 256
Score = 47.0 bits (110), Expect = 2e-05
Identities = 54/183 (29%), Positives = 85/183 (46%), Gaps = 24/183 (13%)
Query: 15 GHSSSEGECAVAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASG--GAQSPLRYLHVLW 72
G +++E V P L EG A+ + L LS +A+G G +S L LH++
Sbjct: 659 GSANAESVQGVTPLHLAAQEG---HAEMVALL------LSKQANGNLGNKSGLTPLHLVA 709
Query: 73 QQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLED 132
Q+ P ++ K G + A R+G T V +++ +++ V+ LL+
Sbjct: 710 QEGHVPVADVLIK--HGVMVDATT---RMGYTPLHV--------ASHYGNIKLVKFLLQH 756
Query: 133 GADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVI 192
AD A G + LH A+ G+ IV LLL +GA PN+ G TPL +A ++ V
Sbjct: 757 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 816
Query: 193 TTL 195
L
Sbjct: 817 DVL 819
Score = 32.7 bits (73), Expect = 0.40
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 3/57 (5%)
Query: 163 LDH---GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
LDH G D N + G LHLA+ HV ++ LL ++ + G T LH+A
Sbjct: 62 LDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIA 118
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 77.4 bits (189), Expect = 1e-14
Identities = 46/109 (42%), Positives = 59/109 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A N VE + LL+ G A +G T LH A+ G+ ++V LLL A+ N +
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN 665
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
G TPLHL A HVPV L++ G VDA R G TPLH+A NI
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Score = 75.5 bits (184), Expect = 5e-14
Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 8/145 (5%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
K + L + +A + ++ V+ LL+ A+ T LH A+ G+ ++ ++LLD
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK------ 219
GA PN R G TPLH+A NHV V+ LL+ GA +DA+ +G TPLH+A
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 220 LNILQEGHAQCLEAVRLEVKQIIHM 244
N+LQ G + + V++E +HM
Sbjct: 421 KNLLQRGASPNVSNVKVETP--LHM 443
Score = 73.2 bits (178), Expect = 3e-13
Identities = 49/116 (42%), Positives = 59/116 (50%), Gaps = 6/116 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A V + LLE A P AA G T LH A + N IV+LLL G P+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQ 229
G TPLH+AA N V V +LL+ G +A G TPLHLA QEGHA+
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA------AQEGHAE 649
Score = 70.1 bits (170), Expect = 2e-12
Identities = 42/114 (36%), Positives = 59/114 (51%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + ++ L + N V ++ LL+ GA A + G T LH AS G+ IV+ L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
L GA PN + TPLH+AA H V LL+ A+V+A + +TPLH A
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 67.8 bits (164), Expect = 1e-11
Identities = 39/100 (39%), Positives = 52/100 (52%)
Query: 118 ANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGN 177
A V L++ G A G T LH AS GN ++V+ LL H AD N + LG
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 178 TPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
+PLH AA H ++T LL+ GA + + G TPL +AK
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 67.4 bits (163), Expect = 1e-11
Identities = 42/119 (35%), Positives = 63/119 (52%), Gaps = 6/119 (5%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
+ L L ++ V+ V +LL KG TALH A+ G D++V+ L+++GA+
Sbjct: 44 NGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
N + G TPL++AA NH+ V+ LL GA + G TPL +A LQ+GH
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA------LQQGH 156
Score = 66.6 bits (161), Expect = 3e-11
Identities = 41/118 (34%), Positives = 59/118 (50%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
R P V L +A A E + LL++ A A +T LH A+ G+ +
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
V+LLL++ A+PN G+TPLH+AA HV + LL A + + G TPLH+A
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 64.3 bits (155), Expect = 1e-10
Identities = 51/171 (29%), Positives = 78/171 (45%), Gaps = 9/171 (5%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A +D T LL++ +P G T LH A+ N + QLLL+ GA N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQC 230
G TPLH+A+ +V ++ LL GA+++ + TPLH A + GH +
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA------ARNGHVRI 287
Query: 231 LEAVRLEVKQIIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVT 281
E + I + L + Q + LD C RL + E +D++T
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD--CVRLLLQYDAE-IDDIT 335
Score = 63.9 bits (154), Expect = 2e-10
Identities = 40/125 (32%), Positives = 60/125 (48%), Gaps = 6/125 (4%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + L L + + N+++ V+ LL G P + G T LH A+ ++ + L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
L +G N G TPLHLAA H ++ LL A + +++G TPLHL +
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL------V 675
Query: 223 LQEGH 227
QEGH
Sbjct: 676 AQEGH 680
Score = 63.5 bits (153), Expect = 2e-10
Identities = 44/128 (34%), Positives = 63/128 (49%), Gaps = 6/128 (4%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A VETV LLE A KG T LH A+ G ++ +LLL+ A PN
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK------LNILQEGH 227
G TPLH+A N++ ++ LL G + G TPLH+A + ++LQ G
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 228 AQCLEAVR 235
+ E+V+
Sbjct: 627 SANAESVQ 634
Score = 62.0 bits (149), Expect = 6e-10
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 6/109 (5%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
V+ LL+ GA P ++ K T LH A+ G+ ++ + LL + A N + TPLH AA
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
H ++ LL A + AG TPLH+A +EGH + + A+
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIA------AREGHVETVLAL 522
Score = 58.2 bits (139), Expect = 9e-09
Identities = 35/106 (33%), Positives = 55/106 (51%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A+ + LL+ GA P + G T LH A + ++++LLL GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH+A+ H+P++ LL+ GA + + TPLH+A
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 57.8 bits (138), Expect = 1e-08
Identities = 35/103 (33%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ +V V+ LL+ GA T LH A+ NG+ +I ++LLDHGA +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G +P+H+AA +H+ + LL+ A +D + TPLH+A
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 56.6 bits (135), Expect = 3e-08
Identities = 39/109 (35%), Positives = 52/109 (47%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A V+ LLE+ A+P A G T LH A+ G+ + V LL+ A
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
G TPLH+AA V V LL A +A + G TPLH+A N+
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 6/122 (4%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
+ V + L +A E V LL A+ + G T LH + G+ + +L+ H
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQE 225
G + +G TPLH+A+ ++ ++ LL+ A V+A + G +PLH A Q+
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA------AQQ 744
Query: 226 GH 227
GH
Sbjct: 745 GH 746
Score = 48.9 bits (115), Expect = 5e-06
Identities = 40/142 (28%), Positives = 60/142 (42%), Gaps = 31/142 (21%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A A E V++L+ GA+ A KG T L+ A+ + ++V+ LL++GA+ N
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 174 GLGNTP-----------------------------LHLAACTNHVPVITTLLRGGARVDA 204
G TP LH+AA + LL+ D
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 205 LDRAGRTPLHLAK--SKLNILQ 224
L + G TPLH+A LN+ Q
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQ 223
Score = 47.0 bits (110), Expect = 2e-05
Identities = 54/183 (29%), Positives = 85/183 (46%), Gaps = 24/183 (13%)
Query: 15 GHSSSEGECAVAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASG--GAQSPLRYLHVLW 72
G +++E V P L EG A+ + L LS +A+G G +S L LH++
Sbjct: 626 GSANAESVQGVTPLHLAAQEG---HAEMVALL------LSKQANGNLGNKSGLTPLHLVA 676
Query: 73 QQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLED 132
Q+ P ++ K G + A R+G T V +++ +++ V+ LL+
Sbjct: 677 QEGHVPVADVLIK--HGVMVDATT---RMGYTPLHV--------ASHYGNIKLVKFLLQH 723
Query: 133 GADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVI 192
AD A G + LH A+ G+ IV LLL +GA PN+ G TPL +A ++ V
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 193 TTL 195
L
Sbjct: 784 DVL 786
Score = 32.7 bits (73), Expect = 0.40
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 3/57 (5%)
Query: 163 LDH---GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
LDH G D N + G LHLA+ HV ++ LL ++ + G T LH+A
Sbjct: 29 LDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIA 85
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 77.4 bits (189), Expect = 1e-14
Identities = 46/109 (42%), Positives = 59/109 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A N VE + LL+ G A +G T LH A+ G+ ++V LLL A+ N +
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN 665
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
G TPLHL A HVPV L++ G VDA R G TPLH+A NI
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Score = 75.5 bits (184), Expect = 5e-14
Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 8/145 (5%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
K + L + +A + ++ V+ LL+ A+ T LH A+ G+ ++ ++LLD
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK------ 219
GA PN R G TPLH+A NHV V+ LL+ GA +DA+ +G TPLH+A
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 220 LNILQEGHAQCLEAVRLEVKQIIHM 244
N+LQ G + + V++E +HM
Sbjct: 421 KNLLQRGASPNVSNVKVETP--LHM 443
Score = 73.2 bits (178), Expect = 3e-13
Identities = 49/116 (42%), Positives = 59/116 (50%), Gaps = 6/116 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A V + LLE A P AA G T LH A + N IV+LLL G P+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQ 229
G TPLH+AA N V V +LL+ G +A G TPLHLA QEGHA+
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA------AQEGHAE 649
Score = 70.1 bits (170), Expect = 2e-12
Identities = 42/114 (36%), Positives = 59/114 (51%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + ++ L + N V ++ LL+ GA A + G T LH AS G+ IV+ L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
L GA PN + TPLH+AA H V LL+ A+V+A + +TPLH A
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 67.8 bits (164), Expect = 1e-11
Identities = 39/100 (39%), Positives = 52/100 (52%)
Query: 118 ANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGN 177
A V L++ G A G T LH AS GN ++V+ LL H AD N + LG
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 178 TPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
+PLH AA H ++T LL+ GA + + G TPL +AK
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 67.4 bits (163), Expect = 1e-11
Identities = 42/119 (35%), Positives = 63/119 (52%), Gaps = 6/119 (5%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
+ L L ++ V+ V +LL KG TALH A+ G D++V+ L+++GA+
Sbjct: 44 NGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
N + G TPL++AA NH+ V+ LL GA + G TPL +A LQ+GH
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA------LQQGH 156
Score = 66.6 bits (161), Expect = 3e-11
Identities = 41/118 (34%), Positives = 59/118 (50%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
R P V L +A A E + LL++ A A +T LH A+ G+ +
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
V+LLL++ A+PN G+TPLH+AA HV + LL A + + G TPLH+A
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 64.3 bits (155), Expect = 1e-10
Identities = 51/171 (29%), Positives = 78/171 (45%), Gaps = 9/171 (5%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A +D T LL++ +P G T LH A+ N + QLLL+ GA N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQC 230
G TPLH+A+ +V ++ LL GA+++ + TPLH A + GH +
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA------ARNGHVRI 287
Query: 231 LEAVRLEVKQIIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVT 281
E + I + L + Q + LD C RL + E +D++T
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD--CVRLLLQYDAE-IDDIT 335
Score = 63.9 bits (154), Expect = 2e-10
Identities = 40/125 (32%), Positives = 60/125 (48%), Gaps = 6/125 (4%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + L L + + N+++ V+ LL G P + G T LH A+ ++ + L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
L +G N G TPLHLAA H ++ LL A + +++G TPLHL +
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL------V 675
Query: 223 LQEGH 227
QEGH
Sbjct: 676 AQEGH 680
Score = 63.5 bits (153), Expect = 2e-10
Identities = 44/128 (34%), Positives = 63/128 (49%), Gaps = 6/128 (4%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A VETV LLE A KG T LH A+ G ++ +LLL+ A PN
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK------LNILQEGH 227
G TPLH+A N++ ++ LL G + G TPLH+A + ++LQ G
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 228 AQCLEAVR 235
+ E+V+
Sbjct: 627 SANAESVQ 634
Score = 62.0 bits (149), Expect = 6e-10
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 6/109 (5%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
V+ LL+ GA P ++ K T LH A+ G+ ++ + LL + A N + TPLH AA
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
H ++ LL A + AG TPLH+A +EGH + + A+
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIA------AREGHVETVLAL 522
Score = 58.2 bits (139), Expect = 9e-09
Identities = 35/106 (33%), Positives = 55/106 (51%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A+ + LL+ GA P + G T LH A + ++++LLL GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH+A+ H+P++ LL+ GA + + TPLH+A
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 57.8 bits (138), Expect = 1e-08
Identities = 35/103 (33%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ +V V+ LL+ GA T LH A+ NG+ +I ++LLDHGA +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G +P+H+AA +H+ + LL+ A +D + TPLH+A
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 56.6 bits (135), Expect = 3e-08
Identities = 39/109 (35%), Positives = 52/109 (47%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A V+ LLE+ A+P A G T LH A+ G+ + V LL+ A
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
G TPLH+AA V V LL A +A + G TPLH+A N+
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 6/122 (4%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
+ V + L +A E V LL A+ + G T LH + G+ + +L+ H
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQE 225
G + +G TPLH+A+ ++ ++ LL+ A V+A + G +PLH A Q+
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA------AQQ 744
Query: 226 GH 227
GH
Sbjct: 745 GH 746
Score = 48.9 bits (115), Expect = 5e-06
Identities = 40/142 (28%), Positives = 60/142 (42%), Gaps = 31/142 (21%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A A E V++L+ GA+ A KG T L+ A+ + ++V+ LL++GA+ N
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 174 GLGNTP-----------------------------LHLAACTNHVPVITTLLRGGARVDA 204
G TP LH+AA + LL+ D
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 205 LDRAGRTPLHLAK--SKLNILQ 224
L + G TPLH+A LN+ Q
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQ 223
Score = 47.0 bits (110), Expect = 2e-05
Identities = 54/183 (29%), Positives = 85/183 (46%), Gaps = 24/183 (13%)
Query: 15 GHSSSEGECAVAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASG--GAQSPLRYLHVLW 72
G +++E V P L EG A+ + L LS +A+G G +S L LH++
Sbjct: 626 GSANAESVQGVTPLHLAAQEG---HAEMVALL------LSKQANGNLGNKSGLTPLHLVA 676
Query: 73 QQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLED 132
Q+ P ++ K G + A R+G T V +++ +++ V+ LL+
Sbjct: 677 QEGHVPVADVLIK--HGVMVDATT---RMGYTPLHV--------ASHYGNIKLVKFLLQH 723
Query: 133 GADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVI 192
AD A G + LH A+ G+ IV LLL +GA PN+ G TPL +A ++ V
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 193 TTL 195
L
Sbjct: 784 DVL 786
Score = 32.7 bits (73), Expect = 0.40
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 3/57 (5%)
Query: 163 LDH---GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
LDH G D N + G LHLA+ HV ++ LL ++ + G T LH+A
Sbjct: 29 LDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIA 85
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 77.4 bits (189), Expect = 1e-14
Identities = 46/109 (42%), Positives = 59/109 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A N VE + LL+ G A +G T LH A+ G+ ++V LLL A+ N +
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN 665
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
G TPLHL A HVPV L++ G VDA R G TPLH+A NI
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Score = 75.5 bits (184), Expect = 5e-14
Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 8/145 (5%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
K + L + +A + ++ V+ LL+ A+ T LH A+ G+ ++ ++LLD
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK------ 219
GA PN R G TPLH+A NHV V+ LL+ GA +DA+ +G TPLH+A
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 220 LNILQEGHAQCLEAVRLEVKQIIHM 244
N+LQ G + + V++E +HM
Sbjct: 421 KNLLQRGASPNVSNVKVETP--LHM 443
Score = 73.2 bits (178), Expect = 3e-13
Identities = 49/116 (42%), Positives = 59/116 (50%), Gaps = 6/116 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A V + LLE A P AA G T LH A + N IV+LLL G P+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQ 229
G TPLH+AA N V V +LL+ G +A G TPLHLA QEGHA+
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA------AQEGHAE 649
Score = 70.1 bits (170), Expect = 2e-12
Identities = 42/114 (36%), Positives = 59/114 (51%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + ++ L + N V ++ LL+ GA A + G T LH AS G+ IV+ L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
L GA PN + TPLH+AA H V LL+ A+V+A + +TPLH A
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 67.8 bits (164), Expect = 1e-11
Identities = 39/100 (39%), Positives = 52/100 (52%)
Query: 118 ANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGN 177
A V L++ G A G T LH AS GN ++V+ LL H AD N + LG
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 178 TPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
+PLH AA H ++T LL+ GA + + G TPL +AK
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 67.4 bits (163), Expect = 1e-11
Identities = 42/119 (35%), Positives = 63/119 (52%), Gaps = 6/119 (5%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
+ L L ++ V+ V +LL KG TALH A+ G D++V+ L+++GA+
Sbjct: 44 NGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
N + G TPL++AA NH+ V+ LL GA + G TPL +A LQ+GH
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA------LQQGH 156
Score = 66.6 bits (161), Expect = 3e-11
Identities = 41/118 (34%), Positives = 59/118 (50%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
R P V L +A A E + LL++ A A +T LH A+ G+ +
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
V+LLL++ A+PN G+TPLH+AA HV + LL A + + G TPLH+A
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 64.3 bits (155), Expect = 1e-10
Identities = 51/171 (29%), Positives = 78/171 (45%), Gaps = 9/171 (5%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A +D T LL++ +P G T LH A+ N + QLLL+ GA N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQC 230
G TPLH+A+ +V ++ LL GA+++ + TPLH A + GH +
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA------ARNGHVRI 287
Query: 231 LEAVRLEVKQIIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVT 281
E + I + L + Q + LD C RL + E +D++T
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD--CVRLLLQYDAE-IDDIT 335
Score = 63.9 bits (154), Expect = 2e-10
Identities = 40/125 (32%), Positives = 60/125 (48%), Gaps = 6/125 (4%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + L L + + N+++ V+ LL G P + G T LH A+ ++ + L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
L +G N G TPLHLAA H ++ LL A + +++G TPLHL +
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL------V 675
Query: 223 LQEGH 227
QEGH
Sbjct: 676 AQEGH 680
Score = 63.5 bits (153), Expect = 2e-10
Identities = 44/128 (34%), Positives = 63/128 (49%), Gaps = 6/128 (4%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A VETV LLE A KG T LH A+ G ++ +LLL+ A PN
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK------LNILQEGH 227
G TPLH+A N++ ++ LL G + G TPLH+A + ++LQ G
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 228 AQCLEAVR 235
+ E+V+
Sbjct: 627 SANAESVQ 634
Score = 62.0 bits (149), Expect = 6e-10
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 6/109 (5%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
V+ LL+ GA P ++ K T LH A+ G+ ++ + LL + A N + TPLH AA
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
H ++ LL A + AG TPLH+A +EGH + + A+
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIA------AREGHVETVLAL 522
Score = 58.2 bits (139), Expect = 9e-09
Identities = 35/106 (33%), Positives = 55/106 (51%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A+ + LL+ GA P + G T LH A + ++++LLL GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH+A+ H+P++ LL+ GA + + TPLH+A
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 57.8 bits (138), Expect = 1e-08
Identities = 35/103 (33%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ +V V+ LL+ GA T LH A+ NG+ +I ++LLDHGA +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G +P+H+AA +H+ + LL+ A +D + TPLH+A
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 56.6 bits (135), Expect = 3e-08
Identities = 39/109 (35%), Positives = 52/109 (47%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A V+ LLE+ A+P A G T LH A+ G+ + V LL+ A
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
G TPLH+AA V V LL A +A + G TPLH+A N+
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 6/122 (4%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
+ V + L +A E V LL A+ + G T LH + G+ + +L+ H
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQE 225
G + +G TPLH+A+ ++ ++ LL+ A V+A + G +PLH A Q+
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA------AQQ 744
Query: 226 GH 227
GH
Sbjct: 745 GH 746
Score = 48.9 bits (115), Expect = 5e-06
Identities = 40/142 (28%), Positives = 60/142 (42%), Gaps = 31/142 (21%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A A E V++L+ GA+ A KG T L+ A+ + ++V+ LL++GA+ N
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 174 GLGNTP-----------------------------LHLAACTNHVPVITTLLRGGARVDA 204
G TP LH+AA + LL+ D
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 205 LDRAGRTPLHLAK--SKLNILQ 224
L + G TPLH+A LN+ Q
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQ 223
Score = 47.0 bits (110), Expect = 2e-05
Identities = 54/183 (29%), Positives = 85/183 (46%), Gaps = 24/183 (13%)
Query: 15 GHSSSEGECAVAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASG--GAQSPLRYLHVLW 72
G +++E V P L EG A+ + L LS +A+G G +S L LH++
Sbjct: 626 GSANAESVQGVTPLHLAAQEG---HAEMVALL------LSKQANGNLGNKSGLTPLHLVA 676
Query: 73 QQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLED 132
Q+ P ++ K G + A R+G T V +++ +++ V+ LL+
Sbjct: 677 QEGHVPVADVLIK--HGVMVDATT---RMGYTPLHV--------ASHYGNIKLVKFLLQH 723
Query: 133 GADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVI 192
AD A G + LH A+ G+ IV LLL +GA PN+ G TPL +A ++ V
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 193 TTL 195
L
Sbjct: 784 DVL 786
Score = 32.7 bits (73), Expect = 0.40
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 3/57 (5%)
Query: 163 LDH---GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
LDH G D N + G LHLA+ HV ++ LL ++ + G T LH+A
Sbjct: 29 LDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIA 85
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 77.4 bits (189), Expect = 1e-14
Identities = 46/109 (42%), Positives = 59/109 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A N VE + LL+ G A +G T LH A+ G+ ++V LLL A+ N +
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN 665
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
G TPLHL A HVPV L++ G VDA R G TPLH+A NI
Sbjct: 666 KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNI 714
Score = 75.5 bits (184), Expect = 5e-14
Identities = 50/145 (34%), Positives = 78/145 (53%), Gaps = 8/145 (5%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
K + L + +A + ++ V+ LL+ A+ T LH A+ G+ ++ ++LLD
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK------ 219
GA PN R G TPLH+A NHV V+ LL+ GA +DA+ +G TPLH+A
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 220 LNILQEGHAQCLEAVRLEVKQIIHM 244
N+LQ G + + V++E +HM
Sbjct: 421 KNLLQRGASPNVSNVKVETP--LHM 443
Score = 73.2 bits (178), Expect = 3e-13
Identities = 49/116 (42%), Positives = 59/116 (50%), Gaps = 6/116 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A V + LLE A P AA G T LH A + N IV+LLL G P+
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQ 229
G TPLH+AA N V V +LL+ G +A G TPLHLA QEGHA+
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLA------AQEGHAE 649
Score = 70.1 bits (170), Expect = 2e-12
Identities = 42/114 (36%), Positives = 59/114 (51%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + ++ L + N V ++ LL+ GA A + G T LH AS G+ IV+ L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
L GA PN + TPLH+AA H V LL+ A+V+A + +TPLH A
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 67.8 bits (164), Expect = 1e-11
Identities = 39/100 (39%), Positives = 52/100 (52%)
Query: 118 ANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGN 177
A V L++ G A G T LH AS GN ++V+ LL H AD N + LG
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735
Query: 178 TPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
+PLH AA H ++T LL+ GA + + G TPL +AK
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 67.4 bits (163), Expect = 1e-11
Identities = 42/119 (35%), Positives = 63/119 (52%), Gaps = 6/119 (5%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
+ L L ++ V+ V +LL KG TALH A+ G D++V+ L+++GA+
Sbjct: 44 NGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGAN 103
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
N + G TPL++AA NH+ V+ LL GA + G TPL +A LQ+GH
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA------LQQGH 156
Score = 66.6 bits (161), Expect = 3e-11
Identities = 41/118 (34%), Positives = 59/118 (50%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
R P V L +A A E + LL++ A A +T LH A+ G+ +
Sbjct: 426 RGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNM 485
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
V+LLL++ A+PN G+TPLH+AA HV + LL A + + G TPLH+A
Sbjct: 486 VKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 64.3 bits (155), Expect = 1e-10
Identities = 51/171 (29%), Positives = 78/171 (45%), Gaps = 9/171 (5%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A +D T LL++ +P G T LH A+ N + QLLL+ GA N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQC 230
G TPLH+A+ +V ++ LL GA+++ + TPLH A + GH +
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA------ARNGHVRI 287
Query: 231 LEAVRLEVKQIIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVT 281
E + I + L + Q + LD C RL + E +D++T
Sbjct: 288 SEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD--CVRLLLQYDAE-IDDIT 335
Score = 63.9 bits (154), Expect = 2e-10
Identities = 40/125 (32%), Positives = 60/125 (48%), Gaps = 6/125 (4%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + L L + + N+++ V+ LL G P + G T LH A+ ++ + L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
L +G N G TPLHLAA H ++ LL A + +++G TPLHL +
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL------V 675
Query: 223 LQEGH 227
QEGH
Sbjct: 676 AQEGH 680
Score = 63.5 bits (153), Expect = 2e-10
Identities = 44/128 (34%), Positives = 63/128 (49%), Gaps = 6/128 (4%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A VETV LLE A KG T LH A+ G ++ +LLL+ A PN
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK------LNILQEGH 227
G TPLH+A N++ ++ LL G + G TPLH+A + ++LQ G
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 626
Query: 228 AQCLEAVR 235
+ E+V+
Sbjct: 627 SANAESVQ 634
Score = 62.0 bits (149), Expect = 6e-10
Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 6/109 (5%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
V+ LL+ GA P ++ K T LH A+ G+ ++ + LL + A N + TPLH AA
Sbjct: 420 VKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAAR 479
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
H ++ LL A + AG TPLH+A +EGH + + A+
Sbjct: 480 IGHTNMVKLLLENNANPNLATTAGHTPLHIA------AREGHVETVLAL 522
Score = 58.2 bits (139), Expect = 9e-09
Identities = 35/106 (33%), Positives = 55/106 (51%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A+ + LL+ GA P + G T LH A + ++++LLL GA +
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH+A+ H+P++ LL+ GA + + TPLH+A
Sbjct: 399 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 57.8 bits (138), Expect = 1e-08
Identities = 35/103 (33%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ +V V+ LL+ GA T LH A+ NG+ +I ++LLDHGA +
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKT 302
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G +P+H+AA +H+ + LL+ A +D + TPLH+A
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 56.6 bits (135), Expect = 3e-08
Identities = 39/109 (35%), Positives = 52/109 (47%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A V+ LLE+ A+P A G T LH A+ G+ + V LL+ A
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
G TPLH+AA V V LL A +A + G TPLH+A N+
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNL 582
Score = 53.9 bits (128), Expect = 2e-07
Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 6/122 (4%)
Query: 106 KEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
+ V + L +A E V LL A+ + G T LH + G+ + +L+ H
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQE 225
G + +G TPLH+A+ ++ ++ LL+ A V+A + G +PLH A Q+
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA------AQQ 744
Query: 226 GH 227
GH
Sbjct: 745 GH 746
Score = 48.9 bits (115), Expect = 5e-06
Identities = 40/142 (28%), Positives = 60/142 (42%), Gaps = 31/142 (21%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A A E V++L+ GA+ A KG T L+ A+ + ++V+ LL++GA+ N
Sbjct: 82 LHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVAT 141
Query: 174 GLGNTP-----------------------------LHLAACTNHVPVITTLLRGGARVDA 204
G TP LH+AA + LL+ D
Sbjct: 142 EDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV 201
Query: 205 LDRAGRTPLHLAK--SKLNILQ 224
L + G TPLH+A LN+ Q
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQ 223
Score = 47.0 bits (110), Expect = 2e-05
Identities = 54/183 (29%), Positives = 85/183 (46%), Gaps = 24/183 (13%)
Query: 15 GHSSSEGECAVAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASG--GAQSPLRYLHVLW 72
G +++E V P L EG A+ + L LS +A+G G +S L LH++
Sbjct: 626 GSANAESVQGVTPLHLAAQEG---HAEMVALL------LSKQANGNLGNKSGLTPLHLVA 676
Query: 73 QQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLED 132
Q+ P ++ K G + A R+G T V +++ +++ V+ LL+
Sbjct: 677 QEGHVPVADVLIK--HGVMVDATT---RMGYTPLHV--------ASHYGNIKLVKFLLQH 723
Query: 133 GADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVI 192
AD A G + LH A+ G+ IV LLL +GA PN+ G TPL +A ++ V
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVT 783
Query: 193 TTL 195
L
Sbjct: 784 DVL 786
Score = 32.7 bits (73), Expect = 0.40
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 3/57 (5%)
Query: 163 LDH---GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
LDH G D N + G LHLA+ HV ++ LL ++ + G T LH+A
Sbjct: 29 LDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIA 85
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 77.0 bits (188), Expect = 2e-14
Identities = 50/129 (38%), Positives = 70/129 (54%), Gaps = 7/129 (5%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
+ L L +A V VQ+LL G+ +A KG TALH AS G ++V++L+ GA+
Sbjct: 42 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 101
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHA 228
N + G TPL++AA NH+ V+ LL GA G TPL +A LQ+GH
Sbjct: 102 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA------LQQGHN 155
Query: 229 QCLEAVRLE 237
Q + A+ LE
Sbjct: 156 QAV-AILLE 163
Score = 76.3 bits (186), Expect = 3e-14
Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 2/128 (1%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
+R P + ++ L + N ++ ++ L++ GA A + G T +H A+ G+ I
Sbjct: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 425
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK- 217
V LLL +GA P+ + G T LH+AA V V+ LLR GA VDA R +TPLH+A
Sbjct: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485
Query: 218 -SKLNILQ 224
K I+Q
Sbjct: 486 LGKTEIVQ 493
Score = 70.1 bits (170), Expect = 2e-12
Identities = 44/103 (42%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A A VE V+ LL +GA A + +T LH AS G +IVQLLL H A P+
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 506
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH++A V V + LL GA + G TPLH+A
Sbjct: 507 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 549
Score = 70.1 bits (170), Expect = 2e-12
Identities = 45/126 (35%), Positives = 64/126 (50%), Gaps = 2/126 (1%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
RR + L L +A+ ++ + LLE GA P A G T LH A+ QI
Sbjct: 564 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 623
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA-- 216
LL++GA+ N G TPLHLA+ H ++T LL GA + ++G T LHLA
Sbjct: 624 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 683
Query: 217 KSKLNI 222
+ K+N+
Sbjct: 684 EDKVNV 689
Score = 69.7 bits (169), Expect = 3e-12
Identities = 46/131 (35%), Positives = 67/131 (51%), Gaps = 7/131 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A ++ + LL+ A +A G T LH A+ N ++ LLL+ GA P+
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEA 233
G TPLH+AA N + + +TLL GA + + + G TPLHLA QEGH +
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS------QEGHTD-MVT 658
Query: 234 VRLEVKQIIHM 244
+ L+ IHM
Sbjct: 659 LLLDKGANIHM 669
Score = 69.3 bits (168), Expect = 4e-12
Identities = 60/182 (32%), Positives = 89/182 (48%), Gaps = 12/182 (6%)
Query: 73 QQDAEPRD---ELRCKIPAGRLRRAARPHRRLGPT-GKEVHALKRLRDSANANDVETVQQ 128
Q DA+ RD L C +G + R P + + L L +A + VE V+
Sbjct: 270 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 329
Query: 129 LLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNH 188
LL+ A TALH A+ G+ ++ +LLLD A+PN R G TPLH+A N
Sbjct: 330 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 389
Query: 189 VPVITTLLRGGARVDALDRAGRTPLHLA--KSKLNI----LQEGHAQCLEAVRLEVKQII 242
+ V+ L++ GA + A+ +G TP+H+A LNI LQ G + + +R E +
Sbjct: 390 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET--AL 447
Query: 243 HM 244
HM
Sbjct: 448 HM 449
Score = 66.6 bits (161), Expect = 3e-11
Identities = 50/141 (35%), Positives = 68/141 (48%), Gaps = 10/141 (7%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGA--DPNQ 171
L +A+ +V LL GA G T LH AS GN +V+LLLD G D
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 275
Query: 172 RDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCL 231
RDGL TPLH AA + H V+ LL GA + A + G +PLH+A Q H +C+
Sbjct: 276 RDGL--TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA------AQGDHVECV 327
Query: 232 EAVRLEVKQIIHMLREYLERL 252
+ + + + +YL L
Sbjct: 328 KHLLQHKAPVDDVTLDYLTAL 348
Score = 63.2 bits (152), Expect = 3e-10
Identities = 34/106 (32%), Positives = 58/106 (54%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A A +++ V + L+ G D + G ALH A+ G+ +VQ LL G+ + G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
NT LH+A+ V+ L++ GA ++A + G TPL++A + +I
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 122
Score = 62.4 bits (150), Expect = 5e-10
Identities = 53/160 (33%), Positives = 72/160 (45%), Gaps = 13/160 (8%)
Query: 57 ASGGAQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRD 116
A ++ L LHV D + K+ L + A PH T K + L
Sbjct: 568 ADSAGKNGLTPLHVAAHYDNQ-------KVALLLLEKGASPHA----TAKNGYT--PLHI 614
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A N ++ LL GA+ +G T LH AS G+ +V LLLD GA+ + G
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
T LHLAA + V V L + GA DA + G TPL +A
Sbjct: 675 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 714
Score = 61.2 bits (147), Expect = 1e-09
Identities = 42/117 (35%), Positives = 54/117 (46%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + L SA V+ LLE GA A KG T LH A+ G+ + +LL
Sbjct: 502 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
L A + G TPLH+AA ++ V LL GA A + G TPLH+A K
Sbjct: 562 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 618
Score = 61.2 bits (147), Expect = 1e-09
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
+ V LL+ GA+ + G T+LH A+ + +L HGAD + LG TPL +A
Sbjct: 655 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 714
Query: 184 ACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
+V ++ LL+ GA V+A + G TPLH A Q+GH + +
Sbjct: 715 CHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA------AQQGHTHIINVL 759
Score = 59.3 bits (142), Expect = 4e-09
Identities = 47/142 (33%), Positives = 62/142 (43%), Gaps = 37/142 (26%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLL------------- 163
+A N ++ V+ LLE+GA+ A + G T L A G++Q V +LL
Sbjct: 116 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 175
Query: 164 ------------------DHGADP------NQRDGLGNTPLHLAACTNHVPVITTLLRGG 199
DH AD N+ G TPLH+AA +V V T LL G
Sbjct: 176 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 235
Query: 200 ARVDALDRAGRTPLHLAKSKLN 221
A VD R G TPLH+A + N
Sbjct: 236 AAVDFTARNGITPLHVASKRGN 257
Score = 59.3 bits (142), Expect = 4e-09
Identities = 33/88 (37%), Positives = 50/88 (56%)
Query: 129 LLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNH 188
LL++GA P + +G TALH A+ G ++V+ LL +GA + R TPLH+A+
Sbjct: 429 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 488
Query: 189 VPVITTLLRGGARVDALDRAGRTPLHLA 216
++ LL+ A DA G TPLH++
Sbjct: 489 TEIVQLLLQHMAHPDAATTNGYTPLHIS 516
Score = 59.3 bits (142), Expect = 4e-09
Identities = 41/119 (34%), Positives = 59/119 (49%), Gaps = 6/119 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ E VQ LL+ A P AA G T LH ++ G + +LL+ GA +
Sbjct: 480 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 539
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA------KSKLNILQEG 226
G TPLH+AA + V LL+ A D+ + G TPLH+A K L +L++G
Sbjct: 540 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 598
Score = 58.9 bits (141), Expect = 5e-09
Identities = 38/103 (36%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ + V+ LL+ G A G T LH A+ +G+DQ+V+LLL+ GA R
Sbjct: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 308
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G +PLH+AA +HV + LL+ A VD + T LH+A
Sbjct: 309 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 351
Score = 58.9 bits (141), Expect = 5e-09
Identities = 40/107 (37%), Positives = 52/107 (48%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A + V L + GAD A G T L A GN ++V LL GA+ N
Sbjct: 675 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 734
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
+ G TPLH AA H +I LL+ GA+ +A G T L +AK
Sbjct: 735 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
Score = 57.8 bits (138), Expect = 1e-08
Identities = 43/141 (30%), Positives = 67/141 (47%), Gaps = 9/141 (6%)
Query: 141 DKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGA 200
+ G T LH A+ GN + LLL+ GA + G TPLH+A+ + ++ LL G
Sbjct: 210 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 269
Query: 201 RVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQIIHMLREYLERLGQHEQRER 260
++DA R G TPLH A + GH Q +E + ++ + L L Q +
Sbjct: 270 QIDAKTRDGLTPLHCA------ARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 323
Query: 261 LDDLCTRLQMTSTKEQVDEVT 281
++ C + + K VD+VT
Sbjct: 324 VE--CVK-HLLQHKAPVDDVT 341
Score = 57.8 bits (138), Expect = 1e-08
Identities = 34/106 (32%), Positives = 53/106 (50%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A+ + LL+ A+P A G T LH A ++++LL+ +GA
Sbjct: 345 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 404
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TP+H+AA H+ ++ LL+ GA D + G T LH+A
Sbjct: 405 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 450
Score = 53.5 bits (127), Expect = 2e-07
Identities = 51/171 (29%), Positives = 73/171 (42%), Gaps = 20/171 (11%)
Query: 25 VAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASGGAQSPLRYLHVLWQQDAEPRDELRC 84
V P L EG D + L GA + G S LH+ Q+D ++
Sbjct: 642 VTPLHLASQEG---HTDMVTLLLDKGANIHMSTKSGLTS----LHLAAQEDKVNVADILT 694
Query: 85 KIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGR 144
K A + H +LG T V + + +V+ V LL+ GA+ A G
Sbjct: 695 KHGADQ-----DAHTKLGYTPLIV--------ACHYGNVKMVNFLLKQGANVNAKTKNGY 741
Query: 145 TALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTL 195
T LH A+ G+ I+ +LL HGA PN GNT L +A ++ V+ TL
Sbjct: 742 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 44.7 bits (104), Expect = 1e-04
Identities = 35/112 (31%), Positives = 54/112 (48%), Gaps = 6/112 (5%)
Query: 120 ANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTP 179
A E V+ L+++GA+ A G T L+ A+ + +V+ LL++GA+ + G TP
Sbjct: 86 AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 145
Query: 180 LHLAACTNHVPVITTLL----RGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
L +A H + LL +G R+ AL A R KS +LQ H
Sbjct: 146 LAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK--DDTKSAALLLQNDH 195
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 77.0 bits (188), Expect = 2e-14
Identities = 50/129 (38%), Positives = 70/129 (54%), Gaps = 7/129 (5%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
+ L L +A V VQ+LL G+ +A KG TALH AS G ++V++L+ GA+
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHA 228
N + G TPL++AA NH+ V+ LL GA G TPL +A LQ+GH
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA------LQQGHN 176
Query: 229 QCLEAVRLE 237
Q + A+ LE
Sbjct: 177 QAV-AILLE 184
Score = 76.3 bits (186), Expect = 3e-14
Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 2/128 (1%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
+R P + ++ L + N ++ ++ L++ GA A + G T +H A+ G+ I
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK- 217
V LLL +GA P+ + G T LH+AA V V+ LLR GA VDA R +TPLH+A
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
Query: 218 -SKLNILQ 224
K I+Q
Sbjct: 507 LGKTEIVQ 514
Score = 70.1 bits (170), Expect = 2e-12
Identities = 44/103 (42%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A A VE V+ LL +GA A + +T LH AS G +IVQLLL H A P+
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH++A V V + LL GA + G TPLH+A
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570
Score = 70.1 bits (170), Expect = 2e-12
Identities = 45/126 (35%), Positives = 64/126 (50%), Gaps = 2/126 (1%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
RR + L L +A+ ++ + LLE GA P A G T LH A+ QI
Sbjct: 585 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA-- 216
LL++GA+ N G TPLHLA+ H ++T LL GA + ++G T LHLA
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Query: 217 KSKLNI 222
+ K+N+
Sbjct: 705 EDKVNV 710
Score = 69.7 bits (169), Expect = 3e-12
Identities = 46/131 (35%), Positives = 67/131 (51%), Gaps = 7/131 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A ++ + LL+ A +A G T LH A+ N ++ LLL+ GA P+
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEA 233
G TPLH+AA N + + +TLL GA + + + G TPLHLA QEGH +
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS------QEGHTD-MVT 679
Query: 234 VRLEVKQIIHM 244
+ L+ IHM
Sbjct: 680 LLLDKGANIHM 690
Score = 69.3 bits (168), Expect = 4e-12
Identities = 60/182 (32%), Positives = 89/182 (48%), Gaps = 12/182 (6%)
Query: 73 QQDAEPRD---ELRCKIPAGRLRRAARPHRRLGPT-GKEVHALKRLRDSANANDVETVQQ 128
Q DA+ RD L C +G + R P + + L L +A + VE V+
Sbjct: 291 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
Query: 129 LLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNH 188
LL+ A TALH A+ G+ ++ +LLLD A+PN R G TPLH+A N
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410
Query: 189 VPVITTLLRGGARVDALDRAGRTPLHLA--KSKLNI----LQEGHAQCLEAVRLEVKQII 242
+ V+ L++ GA + A+ +G TP+H+A LNI LQ G + + +R E +
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET--AL 468
Query: 243 HM 244
HM
Sbjct: 469 HM 470
Score = 66.6 bits (161), Expect = 3e-11
Identities = 50/141 (35%), Positives = 68/141 (48%), Gaps = 10/141 (7%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGA--DPNQ 171
L +A+ +V LL GA G T LH AS GN +V+LLLD G D
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Query: 172 RDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCL 231
RDGL TPLH AA + H V+ LL GA + A + G +PLH+A Q H +C+
Sbjct: 297 RDGL--TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA------AQGDHVECV 348
Query: 232 EAVRLEVKQIIHMLREYLERL 252
+ + + + +YL L
Sbjct: 349 KHLLQHKAPVDDVTLDYLTAL 369
Score = 63.2 bits (152), Expect = 3e-10
Identities = 34/106 (32%), Positives = 58/106 (54%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A A +++ V + L+ G D + G ALH A+ G+ +VQ LL G+ + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
NT LH+A+ V+ L++ GA ++A + G TPL++A + +I
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
Score = 62.4 bits (150), Expect = 5e-10
Identities = 53/160 (33%), Positives = 72/160 (45%), Gaps = 13/160 (8%)
Query: 57 ASGGAQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRD 116
A ++ L LHV D + K+ L + A PH T K + L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQ-------KVALLLLEKGASPHA----TAKNGYT--PLHI 635
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A N ++ LL GA+ +G T LH AS G+ +V LLLD GA+ + G
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
T LHLAA + V V L + GA DA + G TPL +A
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735
Score = 61.2 bits (147), Expect = 1e-09
Identities = 42/117 (35%), Positives = 54/117 (46%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + L SA V+ LLE GA A KG T LH A+ G+ + +LL
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
L A + G TPLH+AA ++ V LL GA A + G TPLH+A K
Sbjct: 583 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639
Score = 61.2 bits (147), Expect = 1e-09
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
+ V LL+ GA+ + G T+LH A+ + +L HGAD + LG TPL +A
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735
Query: 184 ACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
+V ++ LL+ GA V+A + G TPLH A Q+GH + +
Sbjct: 736 CHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA------AQQGHTHIINVL 780
Score = 59.3 bits (142), Expect = 4e-09
Identities = 47/142 (33%), Positives = 62/142 (43%), Gaps = 37/142 (26%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLL------------- 163
+A N ++ V+ LLE+GA+ A + G T L A G++Q V +LL
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 196
Query: 164 ------------------DHGADP------NQRDGLGNTPLHLAACTNHVPVITTLLRGG 199
DH AD N+ G TPLH+AA +V V T LL G
Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256
Query: 200 ARVDALDRAGRTPLHLAKSKLN 221
A VD R G TPLH+A + N
Sbjct: 257 AAVDFTARNGITPLHVASKRGN 278
Score = 59.3 bits (142), Expect = 4e-09
Identities = 33/88 (37%), Positives = 50/88 (56%)
Query: 129 LLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNH 188
LL++GA P + +G TALH A+ G ++V+ LL +GA + R TPLH+A+
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509
Query: 189 VPVITTLLRGGARVDALDRAGRTPLHLA 216
++ LL+ A DA G TPLH++
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Score = 59.3 bits (142), Expect = 4e-09
Identities = 41/119 (34%), Positives = 59/119 (49%), Gaps = 6/119 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ E VQ LL+ A P AA G T LH ++ G + +LL+ GA +
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA------KSKLNILQEG 226
G TPLH+AA + V LL+ A D+ + G TPLH+A K L +L++G
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619
Score = 58.9 bits (141), Expect = 5e-09
Identities = 38/103 (36%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ + V+ LL+ G A G T LH A+ +G+DQ+V+LLL+ GA R
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 329
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G +PLH+AA +HV + LL+ A VD + T LH+A
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372
Score = 58.9 bits (141), Expect = 5e-09
Identities = 40/107 (37%), Positives = 52/107 (48%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A + V L + GAD A G T L A GN ++V LL GA+ N
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
+ G TPLH AA H +I LL+ GA+ +A G T L +AK
Sbjct: 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Score = 57.8 bits (138), Expect = 1e-08
Identities = 43/141 (30%), Positives = 67/141 (47%), Gaps = 9/141 (6%)
Query: 141 DKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGA 200
+ G T LH A+ GN + LLL+ GA + G TPLH+A+ + ++ LL G
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290
Query: 201 RVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQIIHMLREYLERLGQHEQRER 260
++DA R G TPLH A + GH Q +E + ++ + L L Q +
Sbjct: 291 QIDAKTRDGLTPLHCA------ARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 344
Query: 261 LDDLCTRLQMTSTKEQVDEVT 281
++ C + + K VD+VT
Sbjct: 345 VE--CVK-HLLQHKAPVDDVT 362
Score = 57.8 bits (138), Expect = 1e-08
Identities = 34/106 (32%), Positives = 53/106 (50%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A+ + LL+ A+P A G T LH A ++++LL+ +GA
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TP+H+AA H+ ++ LL+ GA D + G T LH+A
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
Score = 53.5 bits (127), Expect = 2e-07
Identities = 51/171 (29%), Positives = 73/171 (42%), Gaps = 20/171 (11%)
Query: 25 VAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASGGAQSPLRYLHVLWQQDAEPRDELRC 84
V P L EG D + L GA + G S LH+ Q+D ++
Sbjct: 663 VTPLHLASQEG---HTDMVTLLLDKGANIHMSTKSGLTS----LHLAAQEDKVNVADILT 715
Query: 85 KIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGR 144
K A + H +LG T V + + +V+ V LL+ GA+ A G
Sbjct: 716 KHGADQ-----DAHTKLGYTPLIV--------ACHYGNVKMVNFLLKQGANVNAKTKNGY 762
Query: 145 TALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTL 195
T LH A+ G+ I+ +LL HGA PN GNT L +A ++ V+ TL
Sbjct: 763 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 44.7 bits (104), Expect = 1e-04
Identities = 35/112 (31%), Positives = 54/112 (48%), Gaps = 6/112 (5%)
Query: 120 ANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTP 179
A E V+ L+++GA+ A G T L+ A+ + +V+ LL++GA+ + G TP
Sbjct: 107 AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
Query: 180 LHLAACTNHVPVITTLL----RGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
L +A H + LL +G R+ AL A R KS +LQ H
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK--DDTKSAALLLQNDH 216
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 77.0 bits (188), Expect = 2e-14
Identities = 50/129 (38%), Positives = 70/129 (54%), Gaps = 7/129 (5%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
+ L L +A V VQ+LL G+ +A KG TALH AS G ++V++L+ GA+
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHA 228
N + G TPL++AA NH+ V+ LL GA G TPL +A LQ+GH
Sbjct: 123 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA------LQQGHN 176
Query: 229 QCLEAVRLE 237
Q + A+ LE
Sbjct: 177 QAV-AILLE 184
Score = 76.3 bits (186), Expect = 3e-14
Identities = 46/128 (35%), Positives = 69/128 (53%), Gaps = 2/128 (1%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
+R P + ++ L + N ++ ++ L++ GA A + G T +H A+ G+ I
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK- 217
V LLL +GA P+ + G T LH+AA V V+ LLR GA VDA R +TPLH+A
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506
Query: 218 -SKLNILQ 224
K I+Q
Sbjct: 507 LGKTEIVQ 514
Score = 70.1 bits (170), Expect = 2e-12
Identities = 44/103 (42%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A A VE V+ LL +GA A + +T LH AS G +IVQLLL H A P+
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH++A V V + LL GA + G TPLH+A
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570
Score = 70.1 bits (170), Expect = 2e-12
Identities = 45/126 (35%), Positives = 64/126 (50%), Gaps = 2/126 (1%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
RR + L L +A+ ++ + LLE GA P A G T LH A+ QI
Sbjct: 585 RRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQI 644
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA-- 216
LL++GA+ N G TPLHLA+ H ++T LL GA + ++G T LHLA
Sbjct: 645 ASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Query: 217 KSKLNI 222
+ K+N+
Sbjct: 705 EDKVNV 710
Score = 69.7 bits (169), Expect = 3e-12
Identities = 46/131 (35%), Positives = 67/131 (51%), Gaps = 7/131 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A ++ + LL+ A +A G T LH A+ N ++ LLL+ GA P+
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEA 233
G TPLH+AA N + + +TLL GA + + + G TPLHLA QEGH +
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS------QEGHTD-MVT 679
Query: 234 VRLEVKQIIHM 244
+ L+ IHM
Sbjct: 680 LLLDKGANIHM 690
Score = 69.3 bits (168), Expect = 4e-12
Identities = 60/182 (32%), Positives = 89/182 (48%), Gaps = 12/182 (6%)
Query: 73 QQDAEPRD---ELRCKIPAGRLRRAARPHRRLGPT-GKEVHALKRLRDSANANDVETVQQ 128
Q DA+ RD L C +G + R P + + L L +A + VE V+
Sbjct: 291 QIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKH 350
Query: 129 LLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNH 188
LL+ A TALH A+ G+ ++ +LLLD A+PN R G TPLH+A N
Sbjct: 351 LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 410
Query: 189 VPVITTLLRGGARVDALDRAGRTPLHLA--KSKLNI----LQEGHAQCLEAVRLEVKQII 242
+ V+ L++ GA + A+ +G TP+H+A LNI LQ G + + +R E +
Sbjct: 411 IKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGET--AL 468
Query: 243 HM 244
HM
Sbjct: 469 HM 470
Score = 66.6 bits (161), Expect = 3e-11
Identities = 50/141 (35%), Positives = 68/141 (48%), Gaps = 10/141 (7%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGA--DPNQ 171
L +A+ +V LL GA G T LH AS GN +V+LLLD G D
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Query: 172 RDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCL 231
RDGL TPLH AA + H V+ LL GA + A + G +PLH+A Q H +C+
Sbjct: 297 RDGL--TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA------AQGDHVECV 348
Query: 232 EAVRLEVKQIIHMLREYLERL 252
+ + + + +YL L
Sbjct: 349 KHLLQHKAPVDDVTLDYLTAL 369
Score = 63.2 bits (152), Expect = 3e-10
Identities = 34/106 (32%), Positives = 58/106 (54%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A A +++ V + L+ G D + G ALH A+ G+ +VQ LL G+ + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
NT LH+A+ V+ L++ GA ++A + G TPL++A + +I
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
Score = 62.4 bits (150), Expect = 5e-10
Identities = 53/160 (33%), Positives = 72/160 (45%), Gaps = 13/160 (8%)
Query: 57 ASGGAQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRD 116
A ++ L LHV D + K+ L + A PH T K + L
Sbjct: 589 ADSAGKNGLTPLHVAAHYDNQ-------KVALLLLEKGASPHA----TAKNGYT--PLHI 635
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A N ++ LL GA+ +G T LH AS G+ +V LLLD GA+ + G
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
T LHLAA + V V L + GA DA + G TPL +A
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735
Score = 61.2 bits (147), Expect = 1e-09
Identities = 42/117 (35%), Positives = 54/117 (46%)
Query: 103 PTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLL 162
P + L SA V+ LLE GA A KG T LH A+ G+ + +LL
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Query: 163 LDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
L A + G TPLH+AA ++ V LL GA A + G TPLH+A K
Sbjct: 583 LQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639
Score = 61.2 bits (147), Expect = 1e-09
Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
+ V LL+ GA+ + G T+LH A+ + +L HGAD + LG TPL +A
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735
Query: 184 ACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
+V ++ LL+ GA V+A + G TPLH A Q+GH + +
Sbjct: 736 CHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA------AQQGHTHIINVL 780
Score = 59.3 bits (142), Expect = 4e-09
Identities = 47/142 (33%), Positives = 62/142 (43%), Gaps = 37/142 (26%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLL------------- 163
+A N ++ V+ LLE+GA+ A + G T L A G++Q V +LL
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 196
Query: 164 ------------------DHGADP------NQRDGLGNTPLHLAACTNHVPVITTLLRGG 199
DH AD N+ G TPLH+AA +V V T LL G
Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256
Query: 200 ARVDALDRAGRTPLHLAKSKLN 221
A VD R G TPLH+A + N
Sbjct: 257 AAVDFTARNGITPLHVASKRGN 278
Score = 59.3 bits (142), Expect = 4e-09
Identities = 33/88 (37%), Positives = 50/88 (56%)
Query: 129 LLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNH 188
LL++GA P + +G TALH A+ G ++V+ LL +GA + R TPLH+A+
Sbjct: 450 LLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGK 509
Query: 189 VPVITTLLRGGARVDALDRAGRTPLHLA 216
++ LL+ A DA G TPLH++
Sbjct: 510 TEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Score = 59.3 bits (142), Expect = 4e-09
Identities = 41/119 (34%), Positives = 59/119 (49%), Gaps = 6/119 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ E VQ LL+ A P AA G T LH ++ G + +LL+ GA +
Sbjct: 501 LHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA------KSKLNILQEG 226
G TPLH+AA + V LL+ A D+ + G TPLH+A K L +L++G
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619
Score = 58.9 bits (141), Expect = 5e-09
Identities = 38/103 (36%), Positives = 56/103 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ + V+ LL+ G A G T LH A+ +G+DQ+V+LLL+ GA R
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART 329
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G +PLH+AA +HV + LL+ A VD + T LH+A
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372
Score = 58.9 bits (141), Expect = 5e-09
Identities = 40/107 (37%), Positives = 52/107 (48%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A + V L + GAD A G T L A GN ++V LL GA+ N
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
+ G TPLH AA H +I LL+ GA+ +A G T L +AK
Sbjct: 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Score = 57.8 bits (138), Expect = 1e-08
Identities = 43/141 (30%), Positives = 67/141 (47%), Gaps = 9/141 (6%)
Query: 141 DKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGA 200
+ G T LH A+ GN + LLL+ GA + G TPLH+A+ + ++ LL G
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGG 290
Query: 201 RVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQIIHMLREYLERLGQHEQRER 260
++DA R G TPLH A + GH Q +E + ++ + L L Q +
Sbjct: 291 QIDAKTRDGLTPLHCA------ARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDH 344
Query: 261 LDDLCTRLQMTSTKEQVDEVT 281
++ C + + K VD+VT
Sbjct: 345 VE--CVK-HLLQHKAPVDDVT 362
Score = 57.8 bits (138), Expect = 1e-08
Identities = 34/106 (32%), Positives = 53/106 (50%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A+ + LL+ A+P A G T LH A ++++LL+ +GA
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQ 425
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TP+H+AA H+ ++ LL+ GA D + G T LH+A
Sbjct: 426 AITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMA 471
Score = 53.5 bits (127), Expect = 2e-07
Identities = 51/171 (29%), Positives = 73/171 (42%), Gaps = 20/171 (11%)
Query: 25 VAPEPLTDAEGLFSFADFGSALGGGGAGLSGRASGGAQSPLRYLHVLWQQDAEPRDELRC 84
V P L EG D + L GA + G S LH+ Q+D ++
Sbjct: 663 VTPLHLASQEG---HTDMVTLLLDKGANIHMSTKSGLTS----LHLAAQEDKVNVADILT 715
Query: 85 KIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGR 144
K A + H +LG T V + + +V+ V LL+ GA+ A G
Sbjct: 716 KHGADQ-----DAHTKLGYTPLIV--------ACHYGNVKMVNFLLKQGANVNAKTKNGY 762
Query: 145 TALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTL 195
T LH A+ G+ I+ +LL HGA PN GNT L +A ++ V+ TL
Sbjct: 763 TPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 44.7 bits (104), Expect = 1e-04
Identities = 35/112 (31%), Positives = 54/112 (48%), Gaps = 6/112 (5%)
Query: 120 ANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTP 179
A E V+ L+++GA+ A G T L+ A+ + +V+ LL++GA+ + G TP
Sbjct: 107 AGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
Query: 180 LHLAACTNHVPVITTLL----RGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
L +A H + LL +G R+ AL A R KS +LQ H
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK--DDTKSAALLLQNDH 216
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 76.6 bits (187), Expect = 2e-14
Identities = 43/103 (41%), Positives = 57/103 (55%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L SA + VQQLL+ GA P AA G T LH ++ G++ + LLDHGA +
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH+AA + V LL+ A DA ++G TPLH+A
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVA 605
Score = 75.5 bits (184), Expect = 5e-14
Identities = 47/121 (38%), Positives = 67/121 (55%), Gaps = 6/121 (4%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
+ L L ++ VE V +LL+ A+ AA KG TALH AS G ++V++L+ +GA+
Sbjct: 73 NGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGAN 132
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHA 228
N + G TPL++AA NH+ V+ LL GA G TPL +A LQ+GH
Sbjct: 133 VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA------LQQGHD 186
Query: 229 Q 229
Q
Sbjct: 187 Q 187
Score = 75.1 bits (183), Expect = 7e-14
Identities = 41/129 (31%), Positives = 71/129 (55%), Gaps = 2/129 (1%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
++ P K ++ L + N ++ ++ LL+ GA A + G T +H A+ G+ I
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK- 217
V L+ HGA PN + G T LH+AA + V+ L++ GA+V+A + +TPLH++
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 218 -SKLNILQE 225
K +I+Q+
Sbjct: 509 LGKADIVQQ 517
Score = 74.7 bits (182), Expect = 9e-14
Identities = 46/114 (40%), Positives = 59/114 (51%), Gaps = 6/114 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A +E LL+ A P AA G T LH A+ N ++ LLLD GA P+
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
G TPLH+AA N + + TTLL GA +A+ R G +HLA QEGH
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLA------AQEGH 676
Score = 71.6 bits (174), Expect = 8e-13
Identities = 44/119 (36%), Positives = 56/119 (47%)
Query: 98 HRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQ 157
H P V L +A + E V+ L++DGA A +T LH ++ G
Sbjct: 454 HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKAD 513
Query: 158 IVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
IVQ LL GA PN G TPLHL+A H V LL GA + + G TPLH+A
Sbjct: 514 IVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVA 572
Score = 69.3 bits (168), Expect = 4e-12
Identities = 53/162 (32%), Positives = 73/162 (45%), Gaps = 13/162 (8%)
Query: 54 SGRASGGAQSPLRYLHVLWQQDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKR 113
S +S L LHV D + K+ L + A PH +H
Sbjct: 588 SASPDAAGKSGLTPLHVAAHYDNQ-------KVALLLLDQGASPHAAAKNGYTPLHI--- 637
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
+A N ++ LLE GAD A +G ++H A+ G+ +V LLL A+ N +
Sbjct: 638 ---AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSN 694
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHL 215
G TPLHLAA + V V L+ GA VDA + G TPLH+
Sbjct: 695 KSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV 736
Score = 67.4 bits (163), Expect = 1e-11
Identities = 62/226 (27%), Positives = 102/226 (45%), Gaps = 17/226 (7%)
Query: 75 DAEPRD---ELRCKIPAGRLRRAARPHRRLGPT-GKEVHALKRLRDSANANDVETVQQLL 130
DA+ RD L C +G + R P K + L L + + + VQ LL
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLL 354
Query: 131 EDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVP 190
+ + TALH A+ G+ ++ ++LLD A+PN + G TPLH+A N +
Sbjct: 355 QHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIK 414
Query: 191 VITTLLRGGARVDALDRAGRTPLHLA--KSKLNILQE--GHAQCLEAVRLEVKQIIHM-- 244
V+ LL+ GA + A+ +G TP+H+A +NI+ + H + + +HM
Sbjct: 415 VMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAA 474
Query: 245 ------LREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVTDLL 284
+ YL + G + + DD T L +++ + D V LL
Sbjct: 475 RSGQAEVVRYLVQDGAQVEAKAKDDQ-TPLHISARLGKADIVQQLL 519
Score = 67.0 bits (162), Expect = 2e-11
Identities = 41/116 (35%), Positives = 63/116 (54%), Gaps = 2/116 (1%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A+ ++ + LL+ GA P AA G T LH A+ I LL++GAD N
Sbjct: 599 LTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA--KSKLNILQ 224
G +HLAA HV +++ LL A V+ +++G TPLHLA + ++N+ +
Sbjct: 659 AVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAE 714
Score = 65.9 bits (159), Expect = 4e-11
Identities = 37/105 (35%), Positives = 56/105 (53%), Gaps = 6/105 (5%)
Query: 123 VETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHL 182
V V QL+ GA P + +G TALH A+ +G ++V+ L+ GA + TPLH+
Sbjct: 446 VNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHI 505
Query: 183 AACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGH 227
+A ++ LL+ GA +A +G TPLHL+ +EGH
Sbjct: 506 SARLGKADIVQQLLQQGASPNAATTSGYTPLHLS------AREGH 544
Score = 60.8 bits (146), Expect = 1e-09
Identities = 36/116 (31%), Positives = 58/116 (50%), Gaps = 6/116 (5%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A A +E +++G D + G ALH AS G+ ++V LL A+ + G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLE 232
NT LH+A+ V+ L+ GA V+A + G TPL++A QE H + ++
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMA------AQENHLEVVK 157
Score = 60.5 bits (145), Expect = 2e-09
Identities = 49/172 (28%), Positives = 77/172 (44%), Gaps = 9/172 (5%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A +D + LL++ + G T LH A+ GN + LLL+ A +
Sbjct: 203 LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD 262
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQC 230
TPLH+A+ + ++ LL GA++DA R G TPLH + GH Q
Sbjct: 263 FTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG------ARSGHEQV 316
Query: 231 LEAVRLEVKQIIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQVDEVTD 282
+E + I+ + L L Q + L+ C +L + VD+VT+
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGDHLN--CVQL-LLQHNVPVDDVTN 365
Score = 57.8 bits (138), Expect = 1e-08
Identities = 40/110 (36%), Positives = 55/110 (50%), Gaps = 10/110 (9%)
Query: 145 TALHFASCNGNDQIVQLLLDHGA--DPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARV 202
T LH AS GN +V+LLLD GA D RDGL TPLH A + H V+ LL A +
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGL--TPLHCGARSGHEQVVEMLLDRAAPI 327
Query: 203 DALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQIIHMLREYLERL 252
+ + G +PLH+A Q H C++ + + + +YL L
Sbjct: 328 LSKTKNGLSPLHMA------TQGDHLNCVQLLLQHNVPVDDVTNDYLTAL 371
Score = 57.4 bits (137), Expect = 2e-08
Identities = 38/107 (35%), Positives = 49/107 (45%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L +A + V + L+ GA A G T LH GN +IV LL H A N
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK 217
+ G TPLH AA H +I LL+ A + L G T L +A+
Sbjct: 758 AKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIAR 804
Score = 57.0 bits (136), Expect = 2e-08
Identities = 33/118 (27%), Positives = 59/118 (50%), Gaps = 6/118 (5%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A V+ V LL A+ ++ G T LH A+ + ++L++ GA + + +G
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
TPLH+ ++ ++ LL+ A+V+A + G TPLH A Q+GH + +
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA------AQQGHTHIINVL 782
Score = 56.6 bits (135), Expect = 3e-08
Identities = 44/136 (32%), Positives = 59/136 (43%), Gaps = 33/136 (24%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLL------------- 163
+A N +E V+ LL++GA A + G T L A G+DQ+V LLL
Sbjct: 147 AAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPAL 206
Query: 164 ------------------DHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDAL 205
D+ AD + G TPLH+AA ++ V T LL A VD
Sbjct: 207 HIAARKDDTKAAALLLQNDNNADVESKSGF--TPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 206 DRAGRTPLHLAKSKLN 221
R TPLH+A + N
Sbjct: 265 ARNDITPLHVASKRGN 280
Score = 52.0 bits (123), Expect = 6e-07
Identities = 32/103 (31%), Positives = 53/103 (51%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ + V+ LL+ GA A G T LH + +G++Q+V++LLD A +
Sbjct: 272 LHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT 331
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G +PLH+A +H+ + LL+ VD + T LH+A
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVA 374
Score = 46.2 bits (108), Expect = 3e-05
Identities = 32/95 (33%), Positives = 49/95 (51%), Gaps = 4/95 (4%)
Query: 120 ANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTP 179
A E V+ L+ +GA+ A G T L+ A+ + ++V+ LLD+GA + G TP
Sbjct: 117 AGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP 176
Query: 180 LHLAACTNHVPVITTLL----RGGARVDALDRAGR 210
L +A H V++ LL +G R+ AL A R
Sbjct: 177 LAVALQQGHDQVVSLLLENDTKGKVRLPALHIAAR 211
Score = 44.3 bits (103), Expect = 1e-04
Identities = 25/74 (33%), Positives = 39/74 (52%)
Query: 122 DVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLH 181
+++ V LL+ A A G T LH A+ G+ I+ +LL + A PN+ GNT L
Sbjct: 742 NIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALG 801
Query: 182 LAACTNHVPVITTL 195
+A ++ V+ TL
Sbjct: 802 IARRLGYISVVDTL 815
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 75.9 bits (185), Expect = 4e-14
Identities = 45/113 (39%), Positives = 63/113 (55%), Gaps = 2/113 (1%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A D T + LL+ GA A + +G T LH A+ N + + +LL+ ADPN +
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA--KSKLNILQ 224
G TPLH+AA HV ++ L GA +DA R RTPLHLA + K+ +Q
Sbjct: 492 AEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQ 544
Score = 65.5 bits (158), Expect = 6e-11
Identities = 44/117 (37%), Positives = 56/117 (47%), Gaps = 5/117 (4%)
Query: 105 GKEVHALKR-----LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIV 159
G E+ A +R L + V +Q LL+ GA P A D G LH A+ G I
Sbjct: 517 GAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLIC 576
Query: 160 QLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
++LL +GA G TPLHLAA H+ +I L A + AL TPLHLA
Sbjct: 577 KMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
Score = 64.7 bits (156), Expect = 1e-10
Identities = 38/100 (38%), Positives = 53/100 (53%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A + V LL+ GADP AA+ G T LH A V LL+H A+ + R+ +G
Sbjct: 633 AARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVG 692
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
TP HLAA + ++ L+ GA++D D TPL LA
Sbjct: 693 WTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
Score = 63.9 bits (154), Expect = 2e-10
Identities = 41/103 (39%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
Query: 118 ANANDVETVQQLLEDG-ADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
A N+ E V +LL ADP + +G+T LH A+ G+ +V+LL GA+ + +
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNL 527
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
TPLHLA V I LL+ GA DALD++G PLH A ++
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAAR 570
Score = 62.4 bits (150), Expect = 5e-10
Identities = 47/135 (34%), Positives = 60/135 (44%), Gaps = 5/135 (3%)
Query: 99 RRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQI 158
R+ P E L +A V V+ L GA+ A RT LH A G +
Sbjct: 483 RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRA 542
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKS 218
+Q LL GA P+ D G PLH AA + LLR GA ++ G TPLHLA
Sbjct: 543 IQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602
Query: 219 K-----LNILQEGHA 228
K +++L E HA
Sbjct: 603 KGHLEIIHLLAESHA 617
Score = 61.6 bits (148), Expect = 8e-10
Identities = 43/118 (36%), Positives = 57/118 (48%), Gaps = 5/118 (4%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A +E + L E A+ A T LH A+ +G + +V LL GADPN + G
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK-----LNILQEGHAQ 229
TPLHLA + + LL A V A ++ G TP HLA K L +L E AQ
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQ 717
Score = 58.2 bits (139), Expect = 9e-09
Identities = 40/94 (42%), Positives = 46/94 (48%)
Query: 123 VETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHL 182
VE V+ LL D G T L A+ + + LLL HGAD N+ D G PLH
Sbjct: 375 VEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHF 434
Query: 183 AACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
AA LL GA VDA +R G TPLHLA
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLA 468
Score = 56.6 bits (135), Expect = 3e-08
Identities = 35/97 (36%), Positives = 52/97 (53%)
Query: 127 QQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACT 186
+ LL GA +G T LH A+ G+ +I+ LL + A+ + TPLHLAA
Sbjct: 577 KMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARH 636
Query: 187 NHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNIL 223
V++ LL+ GA +A +++G TPLHLA + L
Sbjct: 637 GEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFL 673
Score = 46.6 bits (109), Expect = 3e-05
Identities = 41/143 (28%), Positives = 62/143 (43%), Gaps = 11/143 (7%)
Query: 112 KRLRDSANANDVETVQQLLED------GADPCAADDKGRTALHFASCNGNDQIVQLLLDH 165
+ L DS + N ++ QL + + C ++K T LHF G+ + V+LLL H
Sbjct: 326 QELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKV-TPLHFLVAQGSVEQVRLLLAH 384
Query: 166 GADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK----LN 221
D + + G TPL +AA + LL GA + +D G PLH A
Sbjct: 385 EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444
Query: 222 ILQEGHAQCLEAVRLEVKQIIHM 244
L H C++A E +H+
Sbjct: 445 RLLLDHGACVDAQEREGWTPLHL 467
>gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Homo
sapiens]
Length = 1134
Score = 75.1 bits (183), Expect = 7e-14
Identities = 49/145 (33%), Positives = 76/145 (52%), Gaps = 10/145 (6%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L DS+ + + VQ+++ + DP +D+G TALH A C G+ +IV+ L+ G + N
Sbjct: 933 LALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVN 992
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQC 230
D G TPLH AA N+V V L+ GA V A+ + + A K ++EG+ QC
Sbjct: 993 AADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMT---YSDMQTAADKCEEMEEGYTQC 1049
Query: 231 -------LEAVRLEVKQIIHMLREY 248
E + + K +I+ L +Y
Sbjct: 1050 SQFLYGVQEKMGIMNKGVIYALWDY 1074
>gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo
sapiens]
Length = 1005
Score = 75.1 bits (183), Expect = 7e-14
Identities = 49/145 (33%), Positives = 76/145 (52%), Gaps = 10/145 (6%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L DS+ + + VQ+++ + DP +D+G TALH A C G+ +IV+ L+ G + N
Sbjct: 804 LALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVN 863
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQC 230
D G TPLH AA N+V V L+ GA V A+ + + A K ++EG+ QC
Sbjct: 864 AADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMT---YSDMQTAADKCEEMEEGYTQC 920
Query: 231 -------LEAVRLEVKQIIHMLREY 248
E + + K +I+ L +Y
Sbjct: 921 SQFLYGVQEKMGIMNKGVIYALWDY 945
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 74.3 bits (181), Expect = 1e-13
Identities = 46/114 (40%), Positives = 59/114 (51%), Gaps = 10/114 (8%)
Query: 123 VETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHL 182
V+ V LLE G+ AAD +GRTALH + G + + LLDH A RD G TP+HL
Sbjct: 701 VDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHL 760
Query: 183 AACTNHVPVITTLLRGGARVDALDR----AGRTPLHLAKSKLNILQEGHAQCLE 232
A+ H V+ TLL+ D LD +G +P+H A GH CLE
Sbjct: 761 ASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWAS------YTGHEDCLE 808
Score = 69.3 bits (168), Expect = 4e-12
Identities = 50/167 (29%), Positives = 78/167 (46%), Gaps = 6/167 (3%)
Query: 56 RASGGAQSPLRYLHVLWQQDAEPRDEL-RCKIPAGRLRRAARPHRRLGPTGKEVHALKR- 113
RA+ + L + D RD+L + + RA + L P ++ R
Sbjct: 80 RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139
Query: 114 ----LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADP 169
L + ++ +ETV LL GA D K R LH+A+ G+ ++++LL+ GAD
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
Query: 170 NQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
+D G LH AA + + V+ LLR GA +D + G T LH+A
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
Score = 69.3 bits (168), Expect = 4e-12
Identities = 38/90 (42%), Positives = 48/90 (53%)
Query: 127 QQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACT 186
+ +L G D D+ GRT LH A+ GN + + LLL GAD +RD G TPLH AA
Sbjct: 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Query: 187 NHVPVITTLLRGGARVDALDRAGRTPLHLA 216
TL+ GA V+ D G +PLH A
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYA 496
Score = 68.6 bits (166), Expect = 7e-12
Identities = 45/144 (31%), Positives = 71/144 (49%), Gaps = 11/144 (7%)
Query: 93 RAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASC 152
R A PH P+ + + L++S ++ LL++GADP D +G TA+H+A+
Sbjct: 503 RRAEPHT---PSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAA 559
Query: 153 NGNDQIVQLLLDHGAD--PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGR 210
GN Q ++LLL+ + + + +PLHLAA H + TL +D D GR
Sbjct: 560 YGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR 619
Query: 211 TPLHLAKSKLNILQEGHAQCLEAV 234
T L LA + G +C+E +
Sbjct: 620 TALFLA------TERGSTECVEVL 637
Score = 67.8 bits (164), Expect = 1e-11
Identities = 41/97 (42%), Positives = 57/97 (58%)
Query: 120 ANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTP 179
+ DVE V+ LL + D + RT LH A+ G+ I+QLLL GA+ N +D L TP
Sbjct: 18 SRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTP 77
Query: 180 LHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
LH AA + + V+ LL A V+A D+ +TPLH+A
Sbjct: 78 LHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVA 114
Score = 65.9 bits (159), Expect = 4e-11
Identities = 46/123 (37%), Positives = 62/123 (50%), Gaps = 9/123 (7%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A DV +Q LL GA+ A D T LH A+ + N++++ LLL H AD N RD
Sbjct: 45 LHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARD 104
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEA 233
L TPLH+AA L + ++ DR+GR+ LH A + GH LE
Sbjct: 105 KLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHA------VHSGH---LET 155
Query: 234 VRL 236
V L
Sbjct: 156 VNL 158
Score = 63.9 bits (154), Expect = 2e-10
Identities = 39/104 (37%), Positives = 58/104 (55%), Gaps = 1/104 (0%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A + +E V+ LL GA+ + G TALH A G D + L++ GA+ NQ +
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269
Query: 174 GLGNTPLHLAA-CTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH+AA TN + L+ GA V+ + G++PLH+A
Sbjct: 270 DKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMA 313
Score = 61.6 bits (148), Expect = 8e-10
Identities = 39/110 (35%), Positives = 57/110 (51%), Gaps = 5/110 (4%)
Query: 123 VETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHL 182
+E ++ L+ GAD D KG LH A+ +G ++V+ LL GA+ ++ + GNT LH+
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
Query: 183 AACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLE 232
A V L+ GA V+ + G TPLH+A N A CLE
Sbjct: 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTN-----GALCLE 290
Score = 60.1 bits (144), Expect = 2e-09
Identities = 49/154 (31%), Positives = 65/154 (42%), Gaps = 33/154 (21%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A+ +VE + LL GAD D GRT LH+A+ NG+ Q L+ GA N+ D
Sbjct: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486
Query: 174 GLGNTPLHLAACTN-------HVP---------------------VITTLLRGGARVDAL 205
G +PLH AA ++ H P + LL GA
Sbjct: 487 CKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLR 546
Query: 206 DRAGRTPLHLA-----KSKLNILQEGHAQCLEAV 234
DR G T +H A + L +L E CLE V
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDV 580
Score = 58.5 bits (140), Expect = 7e-09
Identities = 33/100 (33%), Positives = 54/100 (54%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+ + N ++ L+ +GAD +G++ LH A+ +G Q+L+ +G++ + D G
Sbjct: 280 AVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFG 339
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
NTPLH+AA H +I+TL+ GA PLHLA
Sbjct: 340 NTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLA 379
Score = 56.2 bits (134), Expect = 3e-08
Identities = 38/112 (33%), Positives = 55/112 (49%), Gaps = 10/112 (8%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGN-TPLHL 182
E ++ L E + D KGRTAL A+ G+ + V++L HGA ++ TPLH
Sbjct: 599 EALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHA 658
Query: 183 AACTNHVPVITTLLRGGAR---VDALDRAGRTPLHLAKSKLNILQEGHAQCL 231
AA + H + L+ G R D +D G+TPL LA + GH C+
Sbjct: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLA------IMNGHVDCV 704
Score = 53.9 bits (128), Expect = 2e-07
Identities = 38/103 (36%), Positives = 49/103 (47%), Gaps = 7/103 (6%)
Query: 140 DDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLL-RG 198
D KGRT LH A+ N +++LL H A+ N D G T L AA + LL RG
Sbjct: 855 DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914
Query: 199 GARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQI 241
A + LD T LHLA SK GH +C + E + +
Sbjct: 915 KADLTVLDENKNTALHLACSK------GHEKCALMILAETQDL 951
Score = 49.3 bits (116), Expect = 4e-06
Identities = 37/108 (34%), Positives = 52/108 (48%), Gaps = 3/108 (2%)
Query: 114 LRDSANANDVETVQQLLEDG--ADPC-AADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L +A + +++ L++ G AD D G+T L A NG+ V LLL+ G+ +
Sbjct: 656 LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTAD 715
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKS 218
D G T LH A T + LL A V D GRTP+HLA +
Sbjct: 716 AADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASA 763
Score = 48.5 bits (114), Expect = 7e-06
Identities = 38/107 (35%), Positives = 54/107 (50%), Gaps = 4/107 (3%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHG-ADPNQR 172
L +A A++V ++ LL+ A+ A D GRTAL A+ NG V+ LL G AD
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVL 921
Query: 173 DGLGNTPLHLAACTNHVPVITTLL---RGGARVDALDRAGRTPLHLA 216
D NT LHLA H +L + ++A + A + PLH+A
Sbjct: 922 DENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIA 968
Score = 48.1 bits (113), Expect = 9e-06
Identities = 32/74 (43%), Positives = 39/74 (52%), Gaps = 2/74 (2%)
Query: 145 TALHFASCNGNDQIVQLLLDH-GAD-PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARV 202
T LH A N D ++LL GA N RD G TPLH AA ++V + LL+ A V
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEV 884
Query: 203 DALDRAGRTPLHLA 216
+A D GRT L A
Sbjct: 885 NATDHTGRTALMTA 898
Score = 46.2 bits (108), Expect = 3e-05
Identities = 37/141 (26%), Positives = 54/141 (38%), Gaps = 51/141 (36%)
Query: 127 QQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQR-------------- 172
Q L+++G++ AD G T LH A+ G++ ++ L+ +GAD +R
Sbjct: 323 QILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLF 382
Query: 173 -------------------------------------DGLGNTPLHLAACTNHVPVITTL 195
D LG T LH AA +V + L
Sbjct: 383 GFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLL 442
Query: 196 LRGGARVDALDRAGRTPLHLA 216
L GA + D+ GRTPLH A
Sbjct: 443 LSSGADLRRRDKFGRTPLHYA 463
Score = 45.8 bits (107), Expect = 5e-05
Identities = 33/92 (35%), Positives = 47/92 (51%), Gaps = 5/92 (5%)
Query: 135 DPCAA--DDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVI 192
DP A D G + +H+AS G++ ++LLL+H + + +G TPLH A N
Sbjct: 781 DPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTT 839
Query: 193 TTLL--RGGARVDALDRAGRTPLHLAKSKLNI 222
LL G V++ D GRTPLH A N+
Sbjct: 840 EMLLGALGAKIVNSRDAKGRTPLHAAAFADNV 871
Score = 45.8 bits (107), Expect = 5e-05
Identities = 34/103 (33%), Positives = 46/103 (44%), Gaps = 4/103 (3%)
Query: 114 LRDSANANDVETVQQLLEDG-ADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADP--- 169
L +A V+ LL G AD D+ TALH A G+++ ++L D
Sbjct: 895 LMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLI 954
Query: 170 NQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTP 212
N + PLH+AA V+ LL GA V A+D G TP
Sbjct: 955 NATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Score = 44.3 bits (103), Expect = 1e-04
Identities = 26/63 (41%), Positives = 32/63 (50%)
Query: 159 VQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKS 218
V+ LL + N D TPLH AA VP++ LL GA V+A D TPLH A +
Sbjct: 24 VRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAA 83
Query: 219 KLN 221
N
Sbjct: 84 SRN 86
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 73.9 bits (180), Expect = 2e-13
Identities = 46/133 (34%), Positives = 64/133 (48%), Gaps = 1/133 (0%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
+ V+ L E GAD A D G ALH A ++++ LL G + +D GNTPLH+A
Sbjct: 525 DIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 584
Query: 184 ACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVKQIIH 243
++P++ L +D ++ GRTPLHLA + IL CL +E
Sbjct: 585 CKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANN-GILDVVRYLCLMGASVEALTTDG 643
Query: 244 MLREYLERLGQHE 256
E L R QHE
Sbjct: 644 KTAEDLARSEQHE 656
Score = 62.8 bits (151), Expect = 4e-10
Identities = 39/88 (44%), Positives = 47/88 (53%)
Query: 129 LLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNH 188
L E G + + +G T L AS G IV+ L +HGAD N D G+ LHLA
Sbjct: 497 LCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556
Query: 189 VPVITTLLRGGARVDALDRAGRTPLHLA 216
+ VI TLL G VD DR G TPLH+A
Sbjct: 557 MEVIKTLLSQGCFVDYQDRHGNTPLHVA 584
Score = 59.3 bits (142), Expect = 4e-09
Identities = 35/103 (33%), Positives = 51/103 (49%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A V+T++ L E+ D G ALH A+ G+ + QLL G++PN +D
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
TPLH AA + V L G V+ +R G TPL A ++
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASAR 521
Score = 53.1 bits (126), Expect = 3e-07
Identities = 35/97 (36%), Positives = 49/97 (50%)
Query: 123 VETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHL 182
+E ++ LL G D G T LH A +GN IV L + + + + G TPLHL
Sbjct: 557 MEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHL 616
Query: 183 AACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
AA + V+ L GA V+AL G+T LA+S+
Sbjct: 617 AANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSE 653
Score = 51.2 bits (121), Expect = 1e-06
Identities = 30/103 (29%), Positives = 50/103 (48%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A + Q L G++P D + T LH A+ +G + + L + G + N ++
Sbjct: 449 LHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN 508
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPL A+ + ++ L GA ++A D+ G LHLA
Sbjct: 509 REGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 551
Score = 46.2 bits (108), Expect = 3e-05
Identities = 28/108 (25%), Positives = 52/108 (48%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
H L +A +++ +Q L++ G+ D G A+++A+ +G+ ++ L ++
Sbjct: 378 HGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCP 437
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
+ +D G LH+AA H V L G+ + D+ TPLH A
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA 485
Score = 28.1 bits (61), Expect = 9.9
Identities = 25/89 (28%), Positives = 34/89 (38%)
Query: 109 HALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGAD 168
H L + ++ V L E + ++ GRT LH A+ NG +V+ L GA
Sbjct: 576 HGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGAS 635
Query: 169 PNQRDGLGNTPLHLAACTNHVPVITTLLR 197
G T LA H V L R
Sbjct: 636 VEALTTDGKTAEDLARSEQHEHVAGLLAR 664
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 73.6 bits (179), Expect = 2e-13
Identities = 42/93 (45%), Positives = 53/93 (56%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
+ V+ LL++GA+ A DD G LH A G+ ++V LLL HGADPN RD TPLH A
Sbjct: 72 DVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEA 131
Query: 184 ACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
A + V LL+ GA + GRT L LA
Sbjct: 132 AIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
Score = 66.6 bits (161), Expect = 3e-11
Identities = 44/110 (40%), Positives = 61/110 (55%), Gaps = 3/110 (2%)
Query: 112 KRLRDSANANDVETVQQLLEDGADPCAADDKGR--TALHFASCNGNDQIVQLLLDHGADP 169
++L ++A A DVETV++L + C D +GR T LHFA+ +V+ LL HGAD
Sbjct: 494 RQLLEAAKAGDVETVKKLCTVQSVNCR-DIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Query: 170 NQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
+ +D G PLH A H V L++ GA V+ D TPLH A +K
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAK 602
Score = 65.9 bits (159), Expect = 4e-11
Identities = 46/125 (36%), Positives = 61/125 (48%), Gaps = 3/125 (2%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A N V V+ LL+ GAD A D G LH A G+ ++ +LL+ HGA N D
Sbjct: 530 LHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD 589
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAK---SKLNILQEGHAQC 230
TPLH AA + LL+ GA +R G TPL L K + + L G A
Sbjct: 590 LWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAAL 649
Query: 231 LEAVR 235
L+A +
Sbjct: 650 LDAAK 654
Score = 63.2 bits (152), Expect = 3e-10
Identities = 43/107 (40%), Positives = 57/107 (53%), Gaps = 1/107 (0%)
Query: 114 LRDSANANDVETVQQLLEDGADPC-AADDKGRTALHFASCNGNDQIVQLLLDHGADPNQR 172
L +SA + + E + LL C A+D + T LH A+ +IVQLLL HGAD + +
Sbjct: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAK 240
Query: 173 DGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
D PLH A H V L++ GA V+A+D TPLH A SK
Sbjct: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASK 287
Score = 62.8 bits (151), Expect = 4e-10
Identities = 44/117 (37%), Positives = 61/117 (52%), Gaps = 5/117 (4%)
Query: 110 ALKRLRDSANANDVETVQQLLEDGADPCAADDKGR--TALHFASCNGNDQIVQLLLDHGA 167
A + L ++ DVE V++L+ + D GR T LHFA+ G +V+ LL +GA
Sbjct: 24 AARELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGA 82
Query: 168 DPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA--KSKLNI 222
+ RD G PLH A H V+ LLR GA +A D TPLH A K K+++
Sbjct: 83 NVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDV 139
Score = 61.6 bits (148), Expect = 8e-10
Identities = 42/108 (38%), Positives = 56/108 (51%), Gaps = 3/108 (2%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGR--TALHFASCNGNDQIVQLLLDHGADPNQ 171
L D+A + V++L C D +GR T LH A+ N ++ + LL HGAD N
Sbjct: 649 LLDAAKKGCLARVKKLSSPDNVNCR-DTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNA 707
Query: 172 RDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
+D G PLH AA HV V L++ A V+A D+ TPLH A K
Sbjct: 708 QDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQK 755
Score = 60.1 bits (144), Expect = 2e-09
Identities = 46/130 (35%), Positives = 64/130 (49%), Gaps = 5/130 (3%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A N V+ VQ LL+ GAD A D LH A G+ ++ +LL+ HGA N D
Sbjct: 218 AAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQ 277
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA-----KSKLNILQEGHAQCL 231
TPLH AA N V V + LL GA L+ ++ + LA K +L +GH+
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 232 EAVRLEVKQI 241
A +V +I
Sbjct: 338 AAREADVTRI 347
Score = 55.8 bits (133), Expect = 4e-08
Identities = 35/102 (34%), Positives = 50/102 (49%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A N++E + LL+ GAD A D G LH A+ G+ + LL+ + A N D
Sbjct: 686 AAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWA 745
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKS 218
TPLH AA + LL GA ++ G+TPL L +
Sbjct: 746 FTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
Score = 53.9 bits (128), Expect = 2e-07
Identities = 49/146 (33%), Positives = 65/146 (44%), Gaps = 30/146 (20%)
Query: 105 GKEVHA-----LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIV 159
G +VHA L L ++ + E + L++ GA AD T LH A+ G +I
Sbjct: 549 GADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEIC 608
Query: 160 QLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGA------------------- 200
+LLL HGADP +++ GNTPL L + I LLRG A
Sbjct: 609 KLLLQHGADPTKKNRDGNTPLDLV--KDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSS 666
Query: 201 --RVDALDRAGR--TPLHLAKSKLNI 222
V+ D GR TPLHLA N+
Sbjct: 667 PDNVNCRDTQGRHSTPLHLAAGYNNL 692
Score = 50.4 bits (119), Expect = 2e-06
Identities = 34/98 (34%), Positives = 47/98 (47%), Gaps = 5/98 (5%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++ + E V LL GADP A D+ T LH A+ G + +LL HGA+P R+
Sbjct: 95 LHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRN 154
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRT 211
G T L LA P +L G + D L + R+
Sbjct: 155 TDGRTALDLAD-----PSAKAVLTGEYKKDELLESARS 187
Score = 48.9 bits (115), Expect = 5e-06
Identities = 30/75 (40%), Positives = 45/75 (60%), Gaps = 3/75 (4%)
Query: 145 TALHFASCNG---NDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGAR 201
TALH A+ + QI +LLL GA+ N++ TPLH+A+ H V+ +++ A+
Sbjct: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425
Query: 202 VDALDRAGRTPLHLA 216
V+ALD G+T LH A
Sbjct: 426 VNALDNLGQTSLHRA 440
Score = 48.9 bits (115), Expect = 5e-06
Identities = 32/99 (32%), Positives = 47/99 (47%), Gaps = 1/99 (1%)
Query: 129 LLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNH 188
LL GA+ + T LH AS ++ +V++++ H A N D LG T LH AA H
Sbjct: 386 LLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGH 445
Query: 189 VPVITTLLRGGARVDALDRAGRTPLHLAKSKL-NILQEG 226
+ LL G + + G T L + + +LQEG
Sbjct: 446 LQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEG 484
Score = 47.0 bits (110), Expect = 2e-05
Identities = 51/189 (26%), Positives = 78/189 (41%), Gaps = 35/189 (18%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L ++A+ V+ L++ A A D T LH A+ G Q+ LLL HGADP ++
Sbjct: 716 LHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKN 775
Query: 174 GLGNTPLHLAACTNHVPVITT--------------LLRG----GARVDALDRAGRTPLHL 215
G TPL L + + ++T +L G GA DAL +P L
Sbjct: 776 QEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSL 835
Query: 216 -AKSKLNILQEGHAQCLEAV------------RLEVKQIIHMLREYLERLGQHEQRERLD 262
A S L+ L ++ V + EV + + +++ LG E L
Sbjct: 836 SAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLG----LEHLM 891
Query: 263 DLCTRLQMT 271
D+ R Q+T
Sbjct: 892 DIFEREQIT 900
Score = 36.2 bits (82), Expect = 0.036
Identities = 24/62 (38%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Query: 121 NDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPL 180
NDV V+ +++ A A D+ G+T+LH A+ G+ Q +LLL +G DPN G T L
Sbjct: 413 NDV--VEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTAL 470
Query: 181 HL 182
+
Sbjct: 471 QM 472
Score = 35.8 bits (81), Expect = 0.047
Identities = 45/184 (24%), Positives = 72/184 (39%), Gaps = 9/184 (4%)
Query: 105 GKEVHA-----LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIV 159
G +VHA L L ++ + E + L++ GA A D T LH A+ ++
Sbjct: 234 GADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVC 293
Query: 160 QLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPL--HLAK 217
LLL +GADP + + + LA + +G + + A A T + HL+
Sbjct: 294 SLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSL 353
Query: 218 SKLNILQ-EGHAQCLEAVRLEVKQIIHMLREYLERLGQHEQRERLDDLCTRLQMTSTKEQ 276
+N + H L + E L R G + E+ + T L + S K
Sbjct: 354 EMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGAN-INEKTKEFLTPLHVASEKAH 412
Query: 277 VDEV 280
D V
Sbjct: 413 NDVV 416
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 73.2 bits (178), Expect = 3e-13
Identities = 42/103 (40%), Positives = 58/103 (56%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A VE V LL GA+ A D K R ALH+A+ G+ +V LL++HGA+ +D
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
G TPLH AA + V+ LL G +D ++ G T LH+A
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIA 221
Score = 72.4 bits (176), Expect = 5e-13
Identities = 42/109 (38%), Positives = 59/109 (54%)
Query: 108 VHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGA 167
+H++ L +A + ++LL G + D GRT LH A+ GN + ++LL GA
Sbjct: 345 IHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGA 404
Query: 168 DPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
D +++D G TPLH AA H I TL+ GA V+ D GRT LH A
Sbjct: 405 DFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
Score = 70.5 bits (171), Expect = 2e-12
Identities = 44/137 (32%), Positives = 69/137 (50%), Gaps = 8/137 (5%)
Query: 104 TGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLL 163
T K+ L +A+ + V+ LL G + + G TALH A NG D +V L+
Sbjct: 175 TCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234
Query: 164 DHGADPNQRDGLGNTPLHLAACTNHVPV-ITTLLRGGARVDALDRAGRTPLHL------- 215
D+GA+ NQ + G TPLH AA + H + + L+ GA V+ + G++PLH+
Sbjct: 235 DYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRF 294
Query: 216 AKSKLNILQEGHAQCLE 232
+S+ I G C++
Sbjct: 295 TRSQTLIQNGGEIDCVD 311
Score = 66.2 bits (160), Expect = 3e-11
Identities = 52/182 (28%), Positives = 81/182 (44%), Gaps = 11/182 (6%)
Query: 101 LGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQ 160
LG L+R R+ ++ LL++ A+P D +G ++H+A+ G+ Q ++
Sbjct: 465 LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLE 524
Query: 161 LLLD--HGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKS 218
LLL+ + G +PLHLAA H + LL+ +D D GRT L LA
Sbjct: 525 LLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAF 584
Query: 219 KLNILQEGHAQCLEAVRLEVKQIIHMLREYLERLGQHEQRERLDDLCTR--LQMTSTKEQ 276
K GH +C+EA+ + I + +R H LC R L++ E
Sbjct: 585 K------GHTECVEAL-INPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEA 637
Query: 277 VD 278
VD
Sbjct: 638 VD 639
Score = 65.9 bits (159), Expect = 4e-11
Identities = 37/88 (42%), Positives = 52/88 (59%), Gaps = 2/88 (2%)
Query: 139 ADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRG 198
+D GRTALH A+ NG+ ++V LLL GA+ N D LH AA H+ V+ L+
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Query: 199 GARVDALDRAGRTPLHLAKS--KLNILQ 224
GA V D+ G TPLH A S ++N+++
Sbjct: 171 GAEVTCKDKKGYTPLHAAASNGQINVVK 198
Score = 62.8 bits (151), Expect = 4e-10
Identities = 38/103 (36%), Positives = 54/103 (52%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A D E ++ L+ GA A D+ T LH A + +++ VQ+L+ H AD N RD
Sbjct: 20 LHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD 79
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
TPLH+AA V ++ + V+ DR GRT LH A
Sbjct: 80 KNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHA 122
Score = 62.8 bits (151), Expect = 4e-10
Identities = 40/121 (33%), Positives = 61/121 (50%), Gaps = 5/121 (4%)
Query: 112 KRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQ 171
+ L +A ++ V L+ GA+ D KG T LH A+ NG +V+ LL+ G + ++
Sbjct: 150 RALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDE 209
Query: 172 RDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCL 231
+ GNT LH+A V+ L+ GA V+ + G TPLH A + + A CL
Sbjct: 210 INVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTH-----GALCL 264
Query: 232 E 232
E
Sbjct: 265 E 265
Score = 57.8 bits (138), Expect = 1e-08
Identities = 31/88 (35%), Positives = 49/88 (55%)
Query: 129 LLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNH 188
L+ D D + RT LH A+ G+ +I++LL+ GA N +D + TPLH A +
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 189 VPVITTLLRGGARVDALDRAGRTPLHLA 216
+ L++ A V+A D+ +TPLH+A
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVA 89
Score = 57.4 bits (137), Expect = 2e-08
Identities = 35/106 (33%), Positives = 52/106 (49%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L + + E VQ L++ AD A D +T LH A+ N + ++++ + N
Sbjct: 50 LTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVN 109
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
D G T LH AA HV ++ LL GA ++A D+ R LH A
Sbjct: 110 VSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWA 155
Score = 55.1 bits (131), Expect = 8e-08
Identities = 41/120 (34%), Positives = 56/120 (46%), Gaps = 10/120 (8%)
Query: 123 VETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHL 182
++ V LLE A+ D G TALH G+++ VQ+LL+ +D G TPLH
Sbjct: 658 IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHY 717
Query: 183 AACTNHVPVITTLLRGGARVDAL---DRAGRTPLHLAKSKLNILQEGHAQCLEAVRLEVK 239
AA H ++ LL+ + D G TPLH A G+ C+E V LE K
Sbjct: 718 AAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWA------CYNGNENCIE-VLLEQK 770
Score = 53.9 bits (128), Expect = 2e-07
Identities = 40/127 (31%), Positives = 58/127 (45%), Gaps = 35/127 (27%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLL-------------------- 163
E +Q L + D C D++G T LH+A NGN+ +++LL
Sbjct: 729 ELLQMALSE-EDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAI 787
Query: 164 --DHG------------ADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAG 209
DHG + + RD G TPL AA +HV + LLR A V+A+D +G
Sbjct: 788 INDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSG 847
Query: 210 RTPLHLA 216
+T L +A
Sbjct: 848 KTALMMA 854
Score = 52.8 bits (125), Expect = 4e-07
Identities = 34/109 (31%), Positives = 45/109 (41%), Gaps = 6/109 (5%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
+ L GAD LH A+ N + + LL G + + D G T LH AA
Sbjct: 330 INTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAA 389
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCLEAV 234
+V I L GA D+ GRTPLH A + H C+E +
Sbjct: 390 GGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANC------HFHCIETL 432
Score = 51.2 bits (121), Expect = 1e-06
Identities = 32/100 (32%), Positives = 49/100 (49%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A+ + ++ L+ +GAD G++ LH + +G Q L+ +G + + D G
Sbjct: 255 AASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDG 314
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
NTPLH+AA H +I TL GA PLHLA
Sbjct: 315 NTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLA 354
Score = 50.8 bits (120), Expect = 1e-06
Identities = 35/92 (38%), Positives = 45/92 (48%), Gaps = 7/92 (7%)
Query: 140 DDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGG 199
DDKGRT L A+ + + +QLLL H A N D G T L +AA + L+
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870
Query: 200 -ARVDALDRAGRTPLHLAKSKLNILQEGHAQC 230
A + D+ TPLHLA SK GH +C
Sbjct: 871 QADLTVKDKDLNTPLHLACSK------GHEKC 896
Score = 50.4 bits (119), Expect = 2e-06
Identities = 32/95 (33%), Positives = 48/95 (50%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A +VE ++ L GAD D GRT LH+A+ N + ++ L+ GA+ N+ D
Sbjct: 384 LHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRA 208
G T LH AA ++ T L + L+RA
Sbjct: 444 DWGRTALHYAAASDMDRNKTILGNAHDNSEELERA 478
Score = 50.4 bits (119), Expect = 2e-06
Identities = 39/106 (36%), Positives = 49/106 (46%), Gaps = 9/106 (8%)
Query: 129 LLEDGADPCAAD---DKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
LLE +P A D KG+T L A G+ V LLL+ A+ + D LG T LH
Sbjct: 628 LLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIM 687
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQCL 231
T H + LL + D GRTPLH A ++ GHA L
Sbjct: 688 TGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR------GHATWL 727
Score = 48.5 bits (114), Expect = 7e-06
Identities = 32/76 (42%), Positives = 42/76 (55%), Gaps = 1/76 (1%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHG-ADPNQR 172
LR +A A+ VE +Q LL A A D+ G+TAL A+ NG V +L++ AD +
Sbjct: 818 LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVK 877
Query: 173 DGLGNTPLHLAACTNH 188
D NTPLHLA H
Sbjct: 878 DKDLNTPLHLACSKGH 893
Score = 42.0 bits (97), Expect = 7e-04
Identities = 23/56 (41%), Positives = 29/56 (51%)
Query: 161 LLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
+L+ D N D TPLH+AA +I L+ GARV+A D TPLH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRA 56
>gi|38257146 ankyrin repeat domain 46 [Homo sapiens]
Length = 228
Score = 73.2 bits (178), Expect = 3e-13
Identities = 43/98 (43%), Positives = 52/98 (53%), Gaps = 3/98 (3%)
Query: 122 DVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLH 181
D ++LLE G DP D +GRT LH A+ GN I QLL GAD D GNT LH
Sbjct: 24 DFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALH 83
Query: 182 LAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
L HV I L+ G ++D + G TPL LAK +
Sbjct: 84 LC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRR 118
Score = 48.5 bits (114), Expect = 7e-06
Identities = 28/66 (42%), Positives = 36/66 (54%)
Query: 150 ASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAG 209
A +G+ + LL+ G DPN RD G T LHLAA +V + L + GA + A D G
Sbjct: 19 ACIDGDFNYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQG 78
Query: 210 RTPLHL 215
T LHL
Sbjct: 79 NTALHL 84
Score = 34.3 bits (77), Expect = 0.14
Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+A +V+ Q L + GAD A D +G TALH G+ +Q L+ +G + + G
Sbjct: 52 AAARGNVDICQLLHKFGADLLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQG 108
Query: 177 NTPLHLA 183
TPL LA
Sbjct: 109 ATPLVLA 115
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 72.8 bits (177), Expect = 3e-13
Identities = 51/142 (35%), Positives = 71/142 (50%), Gaps = 10/142 (7%)
Query: 121 NDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPL 180
++ E + LL GAD G TALH A+ G+ + +LL HGA+ N +D + TPL
Sbjct: 112 DNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPL 171
Query: 181 HLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK--LNI----LQEGHAQCLEAV 234
H+AA H V LL+ GA V+ G PLHLA +K LNI ++EG + A
Sbjct: 172 HIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQ 231
Query: 235 RLEVKQIIHMLREYLERLGQHE 256
E H+ + R G H+
Sbjct: 232 DNE----DHVPLHFCSRFGHHD 249
Score = 58.2 bits (139), Expect = 9e-09
Identities = 36/106 (33%), Positives = 53/106 (50%), Gaps = 2/106 (1%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L + A +E LL+ GA+ D T LH A+ G++Q+ +LLL GAD N
Sbjct: 135 LTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVN 194
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVD--ALDRAGRTPLH 214
+G+ PLHLA+ + + L+ G++ D A D PLH
Sbjct: 195 VSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 240
Score = 55.1 bits (131), Expect = 8e-08
Identities = 33/91 (36%), Positives = 44/91 (48%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
++ L+ G P G TALH A N +++ LL GAD Q G T LH+A
Sbjct: 84 IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATI 143
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
H+ LL+ GA V+ D TPLH+A
Sbjct: 144 AGHLEAADVLLQHGANVNIQDAVFFTPLHIA 174
Score = 44.7 bits (104), Expect = 1e-04
Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 8/117 (6%)
Query: 108 VHALKRLRDSANANDVETVQQLLEDGADPCAAD-------DKGRTALHFAS-CNGNDQIV 159
V ++RL D + E + G+D + + G + LH C G +
Sbjct: 25 VITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHI 84
Query: 160 QLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
+ L+ G P++ G T LHLA ++ +IT+LL GA + + G T LH+A
Sbjct: 85 RTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIA 141
Score = 33.1 bits (74), Expect = 0.31
Identities = 15/28 (53%), Positives = 20/28 (71%)
Query: 143 GRTALHFASCNGNDQIVQLLLDHGADPN 170
G T LH A +G+ ++VQ LLD+GAD N
Sbjct: 340 GHTGLHSACYHGHIRLVQFLLDNGADMN 367
Score = 28.5 bits (62), Expect = 7.6
Identities = 22/53 (41%), Positives = 24/53 (45%), Gaps = 1/53 (1%)
Query: 170 NQRDGLGNTPLHLAA-CTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLN 221
N R G + LHL C I TL+ G R L R G T LHLA K N
Sbjct: 61 NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDN 113
Score = 28.5 bits (62), Expect = 7.6
Identities = 20/58 (34%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 145 TALHFASCNGND-QIVQLLLDHGA-DPNQRDGLGNTPLHLAACTNHVPVITTLLRGGA 200
TA H A G +V+ LLD + N + G+T LH A H+ ++ LL GA
Sbjct: 307 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 364
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 72.8 bits (177), Expect = 3e-13
Identities = 51/142 (35%), Positives = 71/142 (50%), Gaps = 10/142 (7%)
Query: 121 NDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPL 180
++ E + LL GAD G TALH A+ G+ + +LL HGA+ N +D + TPL
Sbjct: 213 DNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPL 272
Query: 181 HLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK--LNI----LQEGHAQCLEAV 234
H+AA H V LL+ GA V+ G PLHLA +K LNI ++EG + A
Sbjct: 273 HIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQ 332
Query: 235 RLEVKQIIHMLREYLERLGQHE 256
E H+ + R G H+
Sbjct: 333 DNE----DHVPLHFCSRFGHHD 350
Score = 58.2 bits (139), Expect = 9e-09
Identities = 36/106 (33%), Positives = 53/106 (50%), Gaps = 2/106 (1%)
Query: 111 LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170
L L + A +E LL+ GA+ D T LH A+ G++Q+ +LLL GAD N
Sbjct: 236 LTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVN 295
Query: 171 QRDGLGNTPLHLAACTNHVPVITTLLRGGARVD--ALDRAGRTPLH 214
+G+ PLHLA+ + + L+ G++ D A D PLH
Sbjct: 296 VSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLH 341
Score = 55.1 bits (131), Expect = 8e-08
Identities = 33/91 (36%), Positives = 44/91 (48%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAAC 185
++ L+ G P G TALH A N +++ LL GAD Q G T LH+A
Sbjct: 185 IRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATI 244
Query: 186 TNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
H+ LL+ GA V+ D TPLH+A
Sbjct: 245 AGHLEAADVLLQHGANVNIQDAVFFTPLHIA 275
Score = 44.7 bits (104), Expect = 1e-04
Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 8/117 (6%)
Query: 108 VHALKRLRDSANANDVETVQQLLEDGADPCAAD-------DKGRTALHFAS-CNGNDQIV 159
V ++RL D + E + G+D + + G + LH C G +
Sbjct: 126 VITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHI 185
Query: 160 QLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
+ L+ G P++ G T LHLA ++ +IT+LL GA + + G T LH+A
Sbjct: 186 RTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIA 242
Score = 33.1 bits (74), Expect = 0.31
Identities = 15/28 (53%), Positives = 20/28 (71%)
Query: 143 GRTALHFASCNGNDQIVQLLLDHGADPN 170
G T LH A +G+ ++VQ LLD+GAD N
Sbjct: 441 GHTGLHSACYHGHIRLVQFLLDNGADMN 468
Score = 28.5 bits (62), Expect = 7.6
Identities = 22/53 (41%), Positives = 24/53 (45%), Gaps = 1/53 (1%)
Query: 170 NQRDGLGNTPLHLAA-CTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLN 221
N R G + LHL C I TL+ G R L R G T LHLA K N
Sbjct: 162 NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDN 214
Score = 28.5 bits (62), Expect = 7.6
Identities = 20/58 (34%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 145 TALHFASCNGND-QIVQLLLDHGA-DPNQRDGLGNTPLHLAACTNHVPVITTLLRGGA 200
TA H A G +V+ LLD + N + G+T LH A H+ ++ LL GA
Sbjct: 408 TAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA 465
>gi|215820635 protein phosphatase 1, regulatory subunit 13 like
[Homo sapiens]
Length = 828
Score = 72.4 bits (176), Expect = 5e-13
Identities = 58/158 (36%), Positives = 78/158 (49%), Gaps = 17/158 (10%)
Query: 74 QDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDG 133
Q E R LR AG R+A R RL P L L D+A ++E VQQ +++
Sbjct: 603 QSMEMRSVLR---KAGSPRKARRA--RLNP-------LVLLLDAALTGELEVVQQAVKEM 650
Query: 134 ADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVIT 193
DP +++G TALH A C N IV L+ GA+ N D G TPLH AA N +
Sbjct: 651 NDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWTPLHCAASCNDTVICM 710
Query: 194 TLLRGGARVDALDRA-GRTPLHLAKSKLNILQEGHAQC 230
L++ GA + A + G T A K + +EG+A C
Sbjct: 711 ALVQHGAAIFATTLSDGAT----AFEKCDPYREGYADC 744
>gi|63003907 protein phosphatase 1, regulatory subunit 13 like [Homo
sapiens]
Length = 828
Score = 72.4 bits (176), Expect = 5e-13
Identities = 58/158 (36%), Positives = 78/158 (49%), Gaps = 17/158 (10%)
Query: 74 QDAEPRDELRCKIPAGRLRRAARPHRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDG 133
Q E R LR AG R+A R RL P L L D+A ++E VQQ +++
Sbjct: 603 QSMEMRSVLR---KAGSPRKARRA--RLNP-------LVLLLDAALTGELEVVQQAVKEM 650
Query: 134 ADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVIT 193
DP +++G TALH A C N IV L+ GA+ N D G TPLH AA N +
Sbjct: 651 NDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPDSHGWTPLHCAASCNDTVICM 710
Query: 194 TLLRGGARVDALDRA-GRTPLHLAKSKLNILQEGHAQC 230
L++ GA + A + G T A K + +EG+A C
Sbjct: 711 ALVQHGAAIFATTLSDGAT----AFEKCDPYREGYADC 744
>gi|38176283 ankyrin repeat and SOCS box-containing protein 7
isoform 2 [Homo sapiens]
Length = 318
Score = 70.9 bits (172), Expect = 1e-12
Identities = 43/123 (34%), Positives = 65/123 (52%), Gaps = 7/123 (5%)
Query: 98 HRRLGPTGKEVHALKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQ 157
H R P E+ +++ + A DV TV+++LE G P D G T LHF++ G ++
Sbjct: 5 HCRRNP---ELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKER 61
Query: 158 IVQLLLDHGADPNQRDGLGN-TPLHLAACTNHVPVITTLLRGGAR---VDALDRAGRTPL 213
V++ L+HGADP +D +G T LH AA + +L R ++A G TPL
Sbjct: 62 CVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPL 121
Query: 214 HLA 216
H+A
Sbjct: 122 HVA 124
Score = 40.8 bits (94), Expect = 0.001
Identities = 42/176 (23%), Positives = 65/176 (36%), Gaps = 40/176 (22%)
Query: 68 LHVLWQQDAEPRDELRCK--IPAGRLRRAARP-HRRLGPTGKEVHALKRLRDSANANDVE 124
LH +++ E ++EL+ + + AG + + + P G++ + L SA
Sbjct: 2 LHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKER 61
Query: 125 TVQQLLEDGADPCAAD-------------------------------------DKGRTAL 147
V+ LE GADP D + G T L
Sbjct: 62 CVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPL 121
Query: 148 HFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVD 203
H A+ G D V+LLL+ A+ + G TPL LA + LL A +D
Sbjct: 122 HVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID 177
Score = 39.7 bits (91), Expect = 0.003
Identities = 41/158 (25%), Positives = 63/158 (39%), Gaps = 41/158 (25%)
Query: 126 VQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGL---------- 175
V+ LLE A+ DKG T L A V++LLDH A+ + ++G
Sbjct: 133 VRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSN 192
Query: 176 ---------------------GNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLH 214
G TPLHL+A + V L GA + + G+TPL
Sbjct: 193 HSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLA 252
Query: 215 L-------AKSKLNILQEGHAQ---CLEAVRLEVKQII 242
+ ++ L+ LQE Q + R++++Q I
Sbjct: 253 VSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCI 290
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 70.9 bits (172), Expect = 1e-12
Identities = 38/96 (39%), Positives = 55/96 (57%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
E + +L D + D RTALH+A G+ +IV+ LL G N +D G +PLH+A
Sbjct: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
Query: 184 ACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
A ++ LL GA+V+A+++ G TPLH A SK
Sbjct: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASK 116
Score = 69.7 bits (169), Expect = 3e-12
Identities = 44/124 (35%), Positives = 67/124 (54%), Gaps = 5/124 (4%)
Query: 105 GKEVHALKR-----LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIV 159
G +V+A+ + L +A+ N E LLE GA+P A D TA+H A+ GN +++
Sbjct: 96 GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
Query: 160 QLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
+LL + A N +D GNTPLHLA V L+ GA + ++ +TPL +AK
Sbjct: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
Query: 220 LNIL 223
L ++
Sbjct: 216 LGLI 219
Score = 69.3 bits (168), Expect = 4e-12
Identities = 42/106 (39%), Positives = 55/106 (51%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+ +A E V+ LL+ G DD G + LH A+ G D+IV+ LL GA N + G
Sbjct: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNI 222
TPLH AA N + LL GGA DA D T +H A +K N+
Sbjct: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNL 152
Score = 63.5 bits (153), Expect = 2e-10
Identities = 38/103 (36%), Positives = 55/103 (53%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A+A E V+ LL GA A + G T LH+A+ +I +LL+ GA+P+ +D
Sbjct: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
Query: 174 GLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLA 216
T +H AA ++ +I LL A + D G TPLHLA
Sbjct: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
Score = 34.7 bits (78), Expect = 0.11
Identities = 19/63 (30%), Positives = 32/63 (50%)
Query: 156 DQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHL 215
+++ + +L + + D T LH A H ++ LL+ G V+ D AG +PLH+
Sbjct: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
Query: 216 AKS 218
A S
Sbjct: 80 AAS 82
>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
sapiens]
Length = 151
Score = 70.9 bits (172), Expect = 1e-12
Identities = 38/96 (39%), Positives = 55/96 (57%)
Query: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
E + +L D + D RTALH+A G+ +IV+ LL G N +D G +PLH+A
Sbjct: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
Query: 184 ACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
A ++ LL GA+V+A+++ G TPLH A SK
Sbjct: 81 ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASK 116
Score = 67.8 bits (164), Expect = 1e-11
Identities = 41/103 (39%), Positives = 53/103 (51%)
Query: 117 SANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLG 176
+ +A E V+ LL+ G DD G + LH A+ G D+IV+ LL GA N + G
Sbjct: 47 ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNG 106
Query: 177 NTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSK 219
TPLH AA N + LL GGA DA D T +H A +K
Sbjct: 107 CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
Score = 45.8 bits (107), Expect = 5e-05
Identities = 26/71 (36%), Positives = 39/71 (54%)
Query: 114 LRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRD 173
L +A+A E V+ LL GA A + G T LH+A+ +I +LL+ GA+P+ +D
Sbjct: 77 LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
Query: 174 GLGNTPLHLAA 184
T +H AA
Sbjct: 137 HYEATAMHRAA 147
Score = 34.7 bits (78), Expect = 0.11
Identities = 19/63 (30%), Positives = 32/63 (50%)
Query: 156 DQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHL 215
+++ + +L + + D T LH A H ++ LL+ G V+ D AG +PLH+
Sbjct: 20 EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
Query: 216 AKS 218
A S
Sbjct: 80 AAS 82
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,083,807
Number of Sequences: 37866
Number of extensions: 591152
Number of successful extensions: 5521
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 376
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 2849
Number of HSP's gapped (non-prelim): 1901
length of query: 300
length of database: 18,247,518
effective HSP length: 102
effective length of query: 198
effective length of database: 14,385,186
effective search space: 2848266828
effective search space used: 2848266828
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.