Guide to the Human Genome
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Search of human proteins with 201861823

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|201861823 fermitin family homolog 2 isoform 3 [Homo sapiens]
         (633 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|201861823 fermitin family homolog 2 isoform 3 [Homo sapiens]      1290   0.0  
gi|201861813 fermitin family homolog 2 isoform 2 [Homo sapiens]      1286   0.0  
gi|29789006 fermitin family homolog 2 isoform 1 [Homo sapiens]       1264   0.0  
gi|116686114 kindlin-1 [Homo sapiens]                                 800   0.0  
gi|28626504 fermitin family homolog 3 short form [Homo sapiens]       669   0.0  
gi|41281905 fermitin family homolog 3 long form [Homo sapiens]        664   0.0  
gi|223029410 talin 1 [Homo sapiens]                                    62   1e-09
gi|156938343 talin 2 [Homo sapiens]                                    54   3e-07
gi|50897850 KIAA1914 protein isoform 1 [Homo sapiens]                  40   0.005
gi|24308338 KIAA1914 protein isoform 2 [Homo sapiens]                  40   0.005
gi|197382472 actin filament associated protein 1 isoform a [Homo...    37   0.055
gi|40807504 actin filament associated protein 1 [Homo sapiens]         37   0.055
gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]                  36   0.12 
gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]                  36   0.12 
gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]                   36   0.12 
gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]                  36   0.12 
gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]                   36   0.12 
gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]                   36   0.12 
gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]                   36   0.12 
gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]                  36   0.12 
gi|40805104 topoisomerase I binding, arginine/serine-rich [Homo ...    34   0.47 
gi|4506467 radixin [Homo sapiens]                                      33   1.0  
gi|112420958 DNA-directed DNA polymerase nu [Homo sapiens]             32   1.4  
gi|4505531 oxysterol binding protein [Homo sapiens]                    32   2.3  
gi|14550405 postreplication repair protein hRAD18p [Homo sapiens]      31   4.0  
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    31   4.0  
gi|51243032 oxysterol-binding protein-like protein 8 isoform b [...    31   4.0  
gi|18079218 oxysterol-binding protein-like protein 8 isoform a [...    31   4.0  
gi|4759198 homer 1 [Homo sapiens]                                      30   5.2  
gi|17402873 BRCA2 and CDKN1A-interacting protein isoform C [Homo...    30   5.2  

>gi|201861823 fermitin family homolog 2 isoform 3 [Homo sapiens]
          Length = 633

 Score = 1290 bits (3337), Expect = 0.0
 Identities = 633/633 (100%), Positives = 633/633 (100%)

Query: 1   MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60
           MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD
Sbjct: 1   MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60

Query: 61  HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120
           HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF
Sbjct: 61  HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120

Query: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180
           KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS
Sbjct: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180

Query: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240
           SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ
Sbjct: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240

Query: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
           ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW
Sbjct: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300

Query: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
           AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG
Sbjct: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360

Query: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420
           KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ
Sbjct: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420

Query: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480
           MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM
Sbjct: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480

Query: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD 540
           ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD
Sbjct: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD 540

Query: 541 LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 600
           LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL
Sbjct: 541 LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 600

Query: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMVNS 633
           IRMDASTGDAIKTWRFSNMKQWNVNWEIKMVNS
Sbjct: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMVNS 633


>gi|201861813 fermitin family homolog 2 isoform 2 [Homo sapiens]
          Length = 687

 Score = 1286 bits (3327), Expect = 0.0
 Identities = 631/631 (100%), Positives = 631/631 (100%)

Query: 1   MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60
           MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD
Sbjct: 1   MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60

Query: 61  HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120
           HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF
Sbjct: 61  HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120

Query: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180
           KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS
Sbjct: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180

Query: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240
           SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ
Sbjct: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240

Query: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
           ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW
Sbjct: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300

Query: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
           AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG
Sbjct: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360

Query: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420
           KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ
Sbjct: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420

Query: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480
           MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM
Sbjct: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480

Query: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD 540
           ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD
Sbjct: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD 540

Query: 541 LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 600
           LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL
Sbjct: 541 LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 600

Query: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMV 631
           IRMDASTGDAIKTWRFSNMKQWNVNWEIKMV
Sbjct: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMV 631


>gi|29789006 fermitin family homolog 2 isoform 1 [Homo sapiens]
          Length = 680

 Score = 1264 bits (3270), Expect = 0.0
 Identities = 624/631 (98%), Positives = 624/631 (98%), Gaps = 7/631 (1%)

Query: 1   MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60
           MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD
Sbjct: 1   MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60

Query: 61  HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120
           HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF
Sbjct: 61  HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120

Query: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180
           KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS
Sbjct: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180

Query: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240
           SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ
Sbjct: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240

Query: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
           ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW
Sbjct: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300

Query: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
           AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG
Sbjct: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360

Query: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420
           KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ
Sbjct: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420

Query: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480
           MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM
Sbjct: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480

Query: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD 540
           ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQ      
Sbjct: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQ------ 534

Query: 541 LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 600
            ITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL
Sbjct: 535 -ITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 593

Query: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMV 631
           IRMDASTGDAIKTWRFSNMKQWNVNWEIKMV
Sbjct: 594 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMV 624


>gi|116686114 kindlin-1 [Homo sapiens]
          Length = 677

 Score =  800 bits (2067), Expect = 0.0
 Identities = 395/622 (63%), Positives = 492/622 (79%), Gaps = 18/622 (2%)

Query: 17  TWELSVHVTDLN----RDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWL 72
           +WEL V V   N    +DVTLRV+G++H+GGVMLKLVE++++ +DWSD ALWWE+K  WL
Sbjct: 11  SWELVVRVDHPNEEQQKDVTLRVSGDLHVGGVMLKLVEQINISQDWSDFALWWEQKHCWL 70

Query: 73  LKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNI 132
           LKTHWTLDKYG+QADAKL FTPQHK+LRL+LPN+K V+++V+FS  VFKAVSDICK  NI
Sbjct: 71  LKTHWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKILNI 130

Query: 133 RHPEELSLLKKPRDPTKKKKKKLDDQSE---DEALELEGPLITPGSGSIYSSPGLYSKTM 189
           R  EELSLLK   D  KKKKKK  +  E   ++ L LE      GS     SPGLYSKTM
Sbjct: 131 RRSEELSLLKPSGDYFKKKKKKDKNNKEPIIEDILNLESSPTASGSS---VSPGLYSKTM 187

Query: 190 TPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQALLDKAKIN 249
           TP YD  +G+P S T  WF DS L+E N  ILA SQP  SPE LA M++P++L+DKAK+N
Sbjct: 188 TPIYDPINGTPASSTMTWFSDSPLTEQNCSILAFSQPPQSPEALADMYQPRSLVDKAKLN 247

Query: 250 QGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIEC 309
            GWLDSSRSLMEQ ++E+E LLLRFKYYSFFDLNPKYDA+RINQLYEQA+WAILLEEI+C
Sbjct: 248 AGWLDSSRSLMEQGIQEDEQLLLRFKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDC 307

Query: 310 TEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDI 369
           TEEEM++FAALQYHI+KLS +++E      + EVDE++AALS+LE+TLEGGK  ++L DI
Sbjct: 308 TEEEMLIFAALQYHISKLS-LSAETQDFAGESEVDEIEAALSNLEVTLEGGKADSLLEDI 366

Query: 370 TSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVT 429
           T IP+LAD +K+F+PKKL  K +KQYW  FKDTSI+ +K+KE   G P  ++NLRGCEV 
Sbjct: 367 TDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNKELEQGEPLEKLNLRGCEVV 426

Query: 430 PDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMADSSYNLEV 489
           PDVN++G+KF IKLLIPVA+GMNE++LRCD+E QYA WMAAC LASKGKTMADSSY  EV
Sbjct: 427 PDVNVAGRKFGIKLLIPVADGMNEMYLRCDHENQYAQWMAACMLASKGKTMADSSYQPEV 486

Query: 490 QNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRDLITARILEA 549
            NILSFL+M++ N   Q+       D+ PEC VSPR  K++K+KQ       + ARILEA
Sbjct: 487 LNILSFLRMKNRNSASQVASSLENMDMNPECFVSPRCAKRHKSKQ-------LAARILEA 539

Query: 550 HQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGD 609
           HQNVAQM L+EAK+RFIQAWQSLPEFG+T+++ RF+G KK++++G++YNRLI++DA+TG 
Sbjct: 540 HQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGI 599

Query: 610 AIKTWRFSNMKQWNVNWEIKMV 631
            + TWRF+N+KQWNVNWE + V
Sbjct: 600 PVTTWRFTNIKQWNVNWETRQV 621


>gi|28626504 fermitin family homolog 3 short form [Homo sapiens]
          Length = 663

 Score =  669 bits (1727), Expect = 0.0
 Identities = 336/634 (52%), Positives = 457/634 (72%), Gaps = 38/634 (5%)

Query: 5   GIRMPDGCYADGTWELSVHVTDLNRD---VTLRVTGEVHIGGVMLKLVEKLDVKKDWSDH 61
           G++   G Y D +WEL V V + + +   VTLRVTGE HIGGV+LK+VE+++ K+DWSDH
Sbjct: 3   GMKTASGDYIDSSWELRVFVGEEDPEAESVTLRVTGESHIGGVLLKIVEQINRKQDWSDH 62

Query: 62  ALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFK 121
           A+WWE+KR WLL+THWTLDKYGI ADA+L F PQH+ + L+LPN + ++++ +FS  +F+
Sbjct: 63  AIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRALRLRASFSQPLFQ 122

Query: 122 AVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSS 181
           AV+ IC+  +IRHPEELSLL   R P KK+KKK + + E+E  +L   ++  G      +
Sbjct: 123 AVAAICRLLSIRHPEELSLL---RAPEKKEKKKKEKEPEEELYDLSKVVLAGGV-----A 174

Query: 182 PGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQA 241
           P L+            G P     A F DSA +E    +L+  QP   P +L ++ +P +
Sbjct: 175 PALFR-----------GMP-----AHFSDSAQTEACYHMLSRPQPPPDPLLLQRLPRPSS 218

Query: 242 LLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWA 301
           L DK +++  WLDSSR LM+Q +K  +AL LRFKYYSFFDL+PK D +R+ QLYEQA+W 
Sbjct: 219 LSDKTQLHSRWLDSSRCLMQQGIKAGDALWLRFKYYSFFDLDPKTDPVRLTQLYEQARWD 278

Query: 302 ILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGK 361
           +LLEEI+CTEEEMM+FAALQYHINKLS          +D  +D++D ALS+LE+ LEG  
Sbjct: 279 LLLEEIDCTEEEMMVFAALQYHINKLSQSGEVGEPAGTDPGLDDLDVALSNLEVKLEGSA 338

Query: 362 TSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQM 421
            + +L  +T+IPEL D++++F+P+KLTLKGY+Q+W  FK+T++S YKS++E+ G P  Q+
Sbjct: 339 PTDVLDSLTTIPELKDHLRIFRPRKLTLKGYRQHWVVFKETTLSYYKSQDEAPGDPIQQL 398

Query: 422 NLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMA 481
           NL+GCEV PDVN+SGQKF IKLL+P  EGM+EI+LRC +E+QYA WMA CRLASKG+TMA
Sbjct: 399 NLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYARWMAGCRLASKGRTMA 458

Query: 482 DSSYNLEVQNILSFLKMQHLNP----DPQLIPEQITTDITPECLVSPRYLKKYKNKQPGY 537
           DSSY  EVQ IL+FL +Q        +    P+     + P  LV+PR+ +K+K KQ   
Sbjct: 459 DSSYTSEVQAILAFLSLQRTGSGGPGNHPHGPDASAEGLNPYGLVAPRFQRKFKAKQ--- 515

Query: 538 IRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAY 597
               +T RILEAHQNVAQ+SL EA++RFIQAWQSLP+FGI++ + RF+G +K+E++GIA 
Sbjct: 516 ----LTPRILEAHQNVAQLSLAEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIAN 571

Query: 598 NRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMV 631
           NRLIR+D + GD +KTWRFSNM+QWNVNW+I+ V
Sbjct: 572 NRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQV 605


>gi|41281905 fermitin family homolog 3 long form [Homo sapiens]
          Length = 667

 Score =  664 bits (1712), Expect = 0.0
 Identities = 336/638 (52%), Positives = 457/638 (71%), Gaps = 42/638 (6%)

Query: 5   GIRMPDGCYADGTWELSVHVTDLNRD---VTLRVTGEVHIGGVMLKLVEKLDVKKDWSDH 61
           G++   G Y D +WEL V V + + +   VTLRVTGE HIGGV+LK+VE+++ K+DWSDH
Sbjct: 3   GMKTASGDYIDSSWELRVFVGEEDPEAESVTLRVTGESHIGGVLLKIVEQINRKQDWSDH 62

Query: 62  ALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFK 121
           A+WWE+KR WLL+THWTLDKYGI ADA+L F PQH+ + L+LPN + ++++ +FS  +F+
Sbjct: 63  AIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRALRLRASFSQPLFQ 122

Query: 122 AVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSS 181
           AV+ IC+  +IRHPEELSLL   R P KK+KKK + + E+E  +L   ++  G      +
Sbjct: 123 AVAAICRLLSIRHPEELSLL---RAPEKKEKKKKEKEPEEELYDLSKVVLAGGV-----A 174

Query: 182 PGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQA 241
           P L+            G P     A F DSA +E    +L+  QP   P +L ++ +P +
Sbjct: 175 PALFR-----------GMP-----AHFSDSAQTEACYHMLSRPQPPPDPLLLQRLPRPSS 218

Query: 242 LLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWA 301
           L DK +++  WLDSSR LM+Q +K  +AL LRFKYYSFFDL+PK D +R+ QLYEQA+W 
Sbjct: 219 LSDKTQLHSRWLDSSRCLMQQGIKAGDALWLRFKYYSFFDLDPKTDPVRLTQLYEQARWD 278

Query: 302 ILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGK 361
           +LLEEI+CTEEEMM+FAALQYHINKLS          +D  +D++D ALS+LE+ LEG  
Sbjct: 279 LLLEEIDCTEEEMMVFAALQYHINKLSQSGEVGEPAGTDPGLDDLDVALSNLEVKLEGSA 338

Query: 362 TSTILGDITSIPELADYIKVF----KPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTP 417
            + +L  +T+IPEL D++++F    +P+KLTLKGY+Q+W  FK+T++S YKS++E+ G P
Sbjct: 339 PTDVLDSLTTIPELKDHLRIFRIPRRPRKLTLKGYRQHWVVFKETTLSYYKSQDEAPGDP 398

Query: 418 AHQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKG 477
             Q+NL+GCEV PDVN+SGQKF IKLL+P  EGM+EI+LRC +E+QYA WMA CRLASKG
Sbjct: 399 IQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYARWMAGCRLASKG 458

Query: 478 KTMADSSYNLEVQNILSFLKMQHLNP----DPQLIPEQITTDITPECLVSPRYLKKYKNK 533
           +TMADSSY  EVQ IL+FL +Q        +    P+     + P  LV+PR+ +K+K K
Sbjct: 459 RTMADSSYTSEVQAILAFLSLQRTGSGGPGNHPHGPDASAEGLNPYGLVAPRFQRKFKAK 518

Query: 534 QPGYIRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELI 593
           Q       +T RILEAHQNVAQ+SL EA++RFIQAWQSLP+FGI++ + RF+G +K+E++
Sbjct: 519 Q-------LTPRILEAHQNVAQLSLAEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEIL 571

Query: 594 GIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMV 631
           GIA NRLIR+D + GD +KTWRFSNM+QWNVNW+I+ V
Sbjct: 572 GIANNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQV 609


>gi|223029410 talin 1 [Homo sapiens]
          Length = 2541

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 33/100 (33%), Positives = 60/100 (60%), Gaps = 6/100 (6%)

Query: 527 LKKYKNKQPGYIRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIA--RF 584
           LK +  K+  Y++     +I +AH+N  QMS IEAK+R+++  +SL  +G++ F+   + 
Sbjct: 262 LKDFLPKE--YVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKM 319

Query: 585 QGGKK--EELIGIAYNRLIRMDASTGDAIKTWRFSNMKQW 622
           +G  K    L+GI    ++R+D  T + I+ W  +N+K+W
Sbjct: 320 KGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRW 359



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 27/73 (36%), Positives = 39/73 (53%)

Query: 252 WLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTE 311
           WLD  R+L EQ V+E+E LLLR K++         D +++N LY QA+  IL      + 
Sbjct: 173 WLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSF 232

Query: 312 EEMMMFAALQYHI 324
           ++   FA  Q  I
Sbjct: 233 DKACEFAGFQCQI 245


>gi|156938343 talin 2 [Homo sapiens]
          Length = 2542

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 25/82 (30%), Positives = 51/82 (62%), Gaps = 4/82 (4%)

Query: 545 RILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIA--RFQGGKK--EELIGIAYNRL 600
           RI + H+N  +MS IEAK+++++  +SL  +G++ F+   + +G  K    L+GI  + +
Sbjct: 281 RIFQEHKNCGEMSEIEAKVKYVKLARSLRTYGVSFFLVKEKMKGKNKLVPRLLGITKDSV 340

Query: 601 IRMDASTGDAIKTWRFSNMKQW 622
           +R+D  T + ++ W  + +K+W
Sbjct: 341 MRVDEKTKEVLQEWPLTTVKRW 362



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 31/84 (36%), Positives = 42/84 (50%), Gaps = 4/84 (4%)

Query: 245 KAKINQ----GWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
           KAK++      WLD SR+  EQ V ENE LLLR K++         D +++N LY QA+ 
Sbjct: 164 KAKLHTDDDLNWLDHSRTFREQGVDENETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARD 223

Query: 301 AILLEEIECTEEEMMMFAALQYHI 324
            IL      + E+   F   Q  I
Sbjct: 224 DILNGSHPVSFEKACEFGGFQAQI 247


>gi|50897850 KIAA1914 protein isoform 1 [Homo sapiens]
          Length = 818

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 30/121 (24%), Positives = 51/121 (42%), Gaps = 10/121 (8%)

Query: 359 GGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPA 418
           G K ST L  +    E + Y+ V     L    +K  WC+ +D  +  Y+ +  S     
Sbjct: 340 GRKKSTSLEPVERSLETSSYLNV-----LVNSQWKSRWCSVRDNHLHFYQDRNRSK-VAQ 393

Query: 419 HQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGK 478
             ++L GCEV PD +     ++ ++L    +G     L   + ++  HW+      S  K
Sbjct: 394 QPLSLVGCEVVPDPS-PDHLYSFRIL---HKGEELAKLEAKSSEEMGHWLGLLLSESGSK 449

Query: 479 T 479
           T
Sbjct: 450 T 450


>gi|24308338 KIAA1914 protein isoform 2 [Homo sapiens]
          Length = 814

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 30/121 (24%), Positives = 51/121 (42%), Gaps = 10/121 (8%)

Query: 359 GGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPA 418
           G K ST L  +    E + Y+ V     L    +K  WC+ +D  +  Y+ +  S     
Sbjct: 340 GRKKSTSLEPVERSLETSSYLNV-----LVNSQWKSRWCSVRDNHLHFYQDRNRSK-VAQ 393

Query: 419 HQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGK 478
             ++L GCEV PD +     ++ ++L    +G     L   + ++  HW+      S  K
Sbjct: 394 QPLSLVGCEVVPDPS-PDHLYSFRIL---HKGEELAKLEAKSSEEMGHWLGLLLSESGSK 449

Query: 479 T 479
           T
Sbjct: 450 T 450


>gi|197382472 actin filament associated protein 1 isoform a [Homo
           sapiens]
          Length = 814

 Score = 37.0 bits (84), Expect = 0.055
 Identities = 24/100 (24%), Positives = 46/100 (46%), Gaps = 6/100 (6%)

Query: 379 IKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVT-PDVNISGQ 437
           I  F  +K     + +  C  KDT + CYKS ++    P  ++ L+GC +T    +   +
Sbjct: 156 ICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQ--PQMELPLQGCNITYIPKDSKKK 213

Query: 438 KFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKG 477
           K  +K+     +G + + L   +++Q   W+   + A  G
Sbjct: 214 KHELKI---TQQGTDPLVLAVQSKEQAEQWLKVIKEAYSG 250



 Score = 30.0 bits (66), Expect = 6.8
 Identities = 19/77 (24%), Positives = 33/77 (42%), Gaps = 5/77 (6%)

Query: 392 YKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGM 451
           +++ WC  KD  +  +K + +   T    + LRGCEV P ++ S      +LL     G 
Sbjct: 362 WRERWCRVKDNKLIFHKDRTDLK-THIVSIPLRGCEVIPGLD-SKHPLTFRLL---RNGQ 416

Query: 452 NEIWLRCDNEKQYAHWM 468
               L   + +    W+
Sbjct: 417 EVAVLEASSSEDMGRWI 433


>gi|40807504 actin filament associated protein 1 [Homo sapiens]
          Length = 730

 Score = 37.0 bits (84), Expect = 0.055
 Identities = 24/100 (24%), Positives = 46/100 (46%), Gaps = 6/100 (6%)

Query: 379 IKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVT-PDVNISGQ 437
           I  F  +K     + +  C  KDT + CYKS ++    P  ++ L+GC +T    +   +
Sbjct: 156 ICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQ--PQMELPLQGCNITYIPKDSKKK 213

Query: 438 KFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKG 477
           K  +K+     +G + + L   +++Q   W+   + A  G
Sbjct: 214 KHELKI---TQQGTDPLVLAVQSKEQAEQWLKVIKEAYSG 250



 Score = 30.0 bits (66), Expect = 6.8
 Identities = 19/77 (24%), Positives = 33/77 (42%), Gaps = 5/77 (6%)

Query: 392 YKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGM 451
           +++ WC  KD  +  +K + +   T    + LRGCEV P ++ S      +LL     G 
Sbjct: 362 WRERWCRVKDNKLIFHKDRTDLK-THIVSIPLRGCEVIPGLD-SKHPLTFRLL---RNGQ 416

Query: 452 NEIWLRCDNEKQYAHWM 468
               L   + +    W+
Sbjct: 417 EVAVLEASSSEDMGRWI 433


>gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]
          Length = 1015

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)

Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
           K D ++   L+ Q K+  +LE +E   +E+     LQ     +     +  L +   EV 
Sbjct: 269 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 327

Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
           +V   LSD +    T +      ++GD     TS+ E+    ++F           P K+
Sbjct: 328 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 384

Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
           TL     +   FKD+S     +KEE      H++ LR       GC V+P+   +N+ G 
Sbjct: 385 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 444

Query: 438 KFNIKLLIPVAEGMNEI 454
                +L+ +   +N +
Sbjct: 445 GLQRMVLVDLPGVINTV 461


>gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]
          Length = 997

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)

Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
           K D ++   L+ Q K+  +LE +E   +E+     LQ     +     +  L +   EV 
Sbjct: 251 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 309

Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
           +V   LSD +    T +      ++GD     TS+ E+    ++F           P K+
Sbjct: 310 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 366

Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
           TL     +   FKD+S     +KEE      H++ LR       GC V+P+   +N+ G 
Sbjct: 367 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 426

Query: 438 KFNIKLLIPVAEGMNEI 454
                +L+ +   +N +
Sbjct: 427 GLQRMVLVDLPGVINTV 443


>gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]
          Length = 979

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)

Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
           K D ++   L+ Q K+  +LE +E   +E+     LQ     +     +  L +   EV 
Sbjct: 233 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 291

Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
           +V   LSD +    T +      ++GD     TS+ E+    ++F           P K+
Sbjct: 292 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 348

Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
           TL     +   FKD+S     +KEE      H++ LR       GC V+P+   +N+ G 
Sbjct: 349 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 408

Query: 438 KFNIKLLIPVAEGMNEI 454
                +L+ +   +N +
Sbjct: 409 GLQRMVLVDLPGVINTV 425


>gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]
          Length = 978

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)

Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
           K D ++   L+ Q K+  +LE +E   +E+     LQ     +     +  L +   EV 
Sbjct: 232 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 290

Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
           +V   LSD +    T +      ++GD     TS+ E+    ++F           P K+
Sbjct: 291 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 347

Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
           TL     +   FKD+S     +KEE      H++ LR       GC V+P+   +N+ G 
Sbjct: 348 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 407

Query: 438 KFNIKLLIPVAEGMNEI 454
                +L+ +   +N +
Sbjct: 408 GLQRMVLVDLPGVINTV 424


>gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]
          Length = 961

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)

Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
           K D ++   L+ Q K+  +LE +E   +E+     LQ     +     +  L +   EV 
Sbjct: 215 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 273

Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
           +V   LSD +    T +      ++GD     TS+ E+    ++F           P K+
Sbjct: 274 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 330

Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
           TL     +   FKD+S     +KEE      H++ LR       GC V+P+   +N+ G 
Sbjct: 331 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 390

Query: 438 KFNIKLLIPVAEGMNEI 454
                +L+ +   +N +
Sbjct: 391 GLQRMVLVDLPGVINTV 407


>gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]
          Length = 942

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)

Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
           K D ++   L+ Q K+  +LE +E   +E+     LQ     +     +  L +   EV 
Sbjct: 196 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 254

Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
           +V   LSD +    T +      ++GD     TS+ E+    ++F           P K+
Sbjct: 255 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 311

Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
           TL     +   FKD+S     +KEE      H++ LR       GC V+P+   +N+ G 
Sbjct: 312 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 371

Query: 438 KFNIKLLIPVAEGMNEI 454
                +L+ +   +N +
Sbjct: 372 GLQRMVLVDLPGVINTV 388


>gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]
          Length = 924

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)

Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
           K D ++   L+ Q K+  +LE +E   +E+     LQ     +     +  L +   EV 
Sbjct: 178 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 236

Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
           +V   LSD +    T +      ++GD     TS+ E+    ++F           P K+
Sbjct: 237 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 293

Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
           TL     +   FKD+S     +KEE      H++ LR       GC V+P+   +N+ G 
Sbjct: 294 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 353

Query: 438 KFNIKLLIPVAEGMNEI 454
                +L+ +   +N +
Sbjct: 354 GLQRMVLVDLPGVINTV 370


>gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]
          Length = 960

 Score = 35.8 bits (81), Expect = 0.12
 Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)

Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
           K D ++   L+ Q K+  +LE +E   +E+     LQ     +     +  L +   EV 
Sbjct: 214 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 272

Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
           +V   LSD +    T +      ++GD     TS+ E+    ++F           P K+
Sbjct: 273 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 329

Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
           TL     +   FKD+S     +KEE      H++ LR       GC V+P+   +N+ G 
Sbjct: 330 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 389

Query: 438 KFNIKLLIPVAEGMNEI 454
                +L+ +   +N +
Sbjct: 390 GLQRMVLVDLPGVINTV 406


>gi|40805104 topoisomerase I binding, arginine/serine-rich [Homo
            sapiens]
          Length = 1045

 Score = 33.9 bits (76), Expect = 0.47
 Identities = 16/45 (35%), Positives = 27/45 (60%)

Query: 329  IMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDITSIP 373
            I T  N+LNN++K VD +    + +E TL+  + ST + D+ + P
Sbjct: 968  IATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQP 1012


>gi|4506467 radixin [Homo sapiens]
          Length = 583

 Score = 32.7 bits (73), Expect = 1.0
 Identities = 23/71 (32%), Positives = 38/71 (53%), Gaps = 4/71 (5%)

Query: 252 WLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIR-INQ--LYEQAKWAILLEEIE 308
           WL  ++ + +QDVK+   L  +F+   FF  +   + I+ I Q   + Q K AIL +EI 
Sbjct: 58  WLKLNKKVTQQDVKKENPLQFKFR-AKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIY 116

Query: 309 CTEEEMMMFAA 319
           C  E  ++ A+
Sbjct: 117 CPPETAVLLAS 127


>gi|112420958 DNA-directed DNA polymerase nu [Homo sapiens]
          Length = 900

 Score = 32.3 bits (72), Expect = 1.4
 Identities = 61/292 (20%), Positives = 111/292 (38%), Gaps = 59/292 (20%)

Query: 247 KINQGWLDSSRSLMEQDVKENEALLLR--------FKYYSFFDLNPKYDAIRINQLYEQA 298
           K+N  + +SSR+++ Q+V+EN   L R         K Y  + L    +   I  L    
Sbjct: 380 KVNSTYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVME 439

Query: 299 KWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLE 358
             AI + + E  +   ++ A L+    +   +  E  L  S+ ++ E+      L++ L 
Sbjct: 440 SHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREI--LFGKLKLHLL 497

Query: 359 GGKTSTILGDITSIPELADYI----KVFKPKKLTLKGYKQYW---CTFKDTSISCYKSKE 411
             + S     +   P  ++ +    +   P    +  Y+Q      TF D  ++C K   
Sbjct: 498 SQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGS 557

Query: 412 ESS-----GT-----PAHQMNLRG-----CEVTPDVNISGQKFNIKLLIPVAEGMNEIWL 456
            SS     GT      A   N++G      ++T   N  G++  I  + P          
Sbjct: 558 ISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISP---------- 607

Query: 457 RCDNEKQYAHWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHLNPDPQLI 508
                        A  ++SKG T   + ++     IL+     HL+ DP+L+
Sbjct: 608 ------------RAMFVSSKGHTFLAADFSQIELRILT-----HLSGDPELL 642


>gi|4505531 oxysterol binding protein [Homo sapiens]
          Length = 807

 Score = 31.6 bits (70), Expect = 2.3
 Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 10/106 (9%)

Query: 389 LKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVA 448
           +KGY++ W    +  +S Y+SK E   T    +NL    +T + + +         I   
Sbjct: 102 IKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCN--------FIISN 153

Query: 449 EGMNEIWLRCDNEKQYAHWMAACRLASKG--KTMADSSYNLEVQNI 492
            G     L+  +E +   W+ A  LA     K +A+S  + + +++
Sbjct: 154 GGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESV 199


>gi|14550405 postreplication repair protein hRAD18p [Homo sapiens]
          Length = 495

 Score = 30.8 bits (68), Expect = 4.0
 Identities = 31/123 (25%), Positives = 51/123 (41%), Gaps = 13/123 (10%)

Query: 48  LVEKLDVKKDWSDHALWWEKKRTWLLKTHWT-LDKYGIQADA---KLQFTPQHKLLRLQL 103
           L+   D+KK   +H L  +  +  L+K H   +  Y  Q DA   K       ++  ++ 
Sbjct: 250 LLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEIVQEIENIEK 309

Query: 104 PNMKYVKVKVNFSDRVF------KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDD 157
             M+    K+N S  VF      K + +I   +  +H  E  LL    D  +K  KK+  
Sbjct: 310 TRMRLEASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQLLV---DQARKGYKKIAG 366

Query: 158 QSE 160
            S+
Sbjct: 367 MSQ 369


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 30.8 bits (68), Expect = 4.0
 Identities = 25/106 (23%), Positives = 52/106 (49%), Gaps = 20/106 (18%)

Query: 84   IQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICK-------TFNIRHPE 136
            + A+AK++   + ++L L+  N K++K K    DR+ +  S + +          IR+ +
Sbjct: 974  VTAEAKIK-KMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ 1032

Query: 137  ELSLL---------KKPRDPTKKKKKKLDDQS---EDEALELEGPL 170
            E+ +          +K R   +K K+KLD ++   +D+  EL+  +
Sbjct: 1033 EVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078


>gi|51243032 oxysterol-binding protein-like protein 8 isoform b
           [Homo sapiens]
          Length = 847

 Score = 30.8 bits (68), Expect = 4.0
 Identities = 20/69 (28%), Positives = 35/69 (50%), Gaps = 8/69 (11%)

Query: 362 TSTILGDIT--SIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAH 419
           T  +L  IT  S+  +AD++K+    + TLK + + WC  K   +  YK+  + +G    
Sbjct: 94  TKELLSTITDPSVIVMADWLKI----RGTLKSWTKLWCVLKPGVLLIYKT--QKNGQWVG 147

Query: 420 QMNLRGCEV 428
            + L  CE+
Sbjct: 148 TVLLNACEI 156


>gi|18079218 oxysterol-binding protein-like protein 8 isoform a
           [Homo sapiens]
          Length = 889

 Score = 30.8 bits (68), Expect = 4.0
 Identities = 20/69 (28%), Positives = 35/69 (50%), Gaps = 8/69 (11%)

Query: 362 TSTILGDIT--SIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAH 419
           T  +L  IT  S+  +AD++K+    + TLK + + WC  K   +  YK+  + +G    
Sbjct: 136 TKELLSTITDPSVIVMADWLKI----RGTLKSWTKLWCVLKPGVLLIYKT--QKNGQWVG 189

Query: 420 QMNLRGCEV 428
            + L  CE+
Sbjct: 190 TVLLNACEI 198


>gi|4759198 homer 1 [Homo sapiens]
          Length = 354

 Score = 30.4 bits (67), Expect = 5.2
 Identities = 46/198 (23%), Positives = 82/198 (41%), Gaps = 35/198 (17%)

Query: 188 TMTPTYDAHDG---SPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQALLD 244
           T TP+ ++  G   SPL+P S    +    E  P +   S+P   P   A  F   + + 
Sbjct: 124 TSTPSQESAGGDLQSPLTPESI---NGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAIS 180

Query: 245 K-------------AKINQGWLDSSRSLMEQDVK----ENEALLLRFKYYSFFDLNPKYD 287
           K             AK+    L+S+ ++ +   +    + EA  L  +      ++ + +
Sbjct: 181 KHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQAN 240

Query: 288 AI-----RINQLYEQAKWAILL--EEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSD 340
           A+      +NQ  ++ +  + L  EEIE  ++E+     LQ   + L+    E  + N D
Sbjct: 241 AVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKD 300

Query: 341 KEVDEVDAALSDLEITLE 358
                ++  LSDLE  LE
Sbjct: 301 -----LEGQLSDLEQRLE 313


>gi|17402873 BRCA2 and CDKN1A-interacting protein isoform C [Homo
           sapiens]
          Length = 292

 Score = 30.4 bits (67), Expect = 5.2
 Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 9/107 (8%)

Query: 254 DSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEE 313
           DS +   E+D   +E + + F+ YS  D +  YD I+  +L +Q     L  +      E
Sbjct: 41  DSDKEKDEEDEVIDEEVNIEFEAYSLSDND--YDGIK--KLLQQ-----LFLKAPVNTAE 91

Query: 314 MMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
           +      Q HI  +   T  +  +N D + DEV   +S L +T   G
Sbjct: 92  LTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKG 138


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,899,398
Number of Sequences: 37866
Number of extensions: 1152828
Number of successful extensions: 3462
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 3420
Number of HSP's gapped (non-prelim): 62
length of query: 633
length of database: 18,247,518
effective HSP length: 108
effective length of query: 525
effective length of database: 14,157,990
effective search space: 7432944750
effective search space used: 7432944750
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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