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Search of human proteins with 201861813
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|201861813 fermitin family homolog 2 isoform 2 [Homo sapiens]
(687 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|201861813 fermitin family homolog 2 isoform 2 [Homo sapiens] 1399 0.0
gi|29789006 fermitin family homolog 2 isoform 1 [Homo sapiens] 1377 0.0
gi|201861823 fermitin family homolog 2 isoform 3 [Homo sapiens] 1286 0.0
gi|116686114 kindlin-1 [Homo sapiens] 876 0.0
gi|28626504 fermitin family homolog 3 short form [Homo sapiens] 732 0.0
gi|41281905 fermitin family homolog 3 long form [Homo sapiens] 726 0.0
gi|223029410 talin 1 [Homo sapiens] 69 1e-11
gi|156938343 talin 2 [Homo sapiens] 62 2e-09
gi|50897850 KIAA1914 protein isoform 1 [Homo sapiens] 40 0.006
gi|24308338 KIAA1914 protein isoform 2 [Homo sapiens] 40 0.006
gi|197382472 actin filament associated protein 1 isoform a [Homo... 37 0.061
gi|40807504 actin filament associated protein 1 [Homo sapiens] 37 0.061
gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens] 36 0.14
gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens] 36 0.14
gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens] 36 0.14
gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens] 36 0.14
gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens] 36 0.14
gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens] 36 0.14
gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens] 36 0.14
gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens] 36 0.14
gi|40805104 topoisomerase I binding, arginine/serine-rich [Homo ... 34 0.52
gi|4506467 radixin [Homo sapiens] 33 1.1
gi|112420958 DNA-directed DNA polymerase nu [Homo sapiens] 32 1.5
gi|4505531 oxysterol binding protein [Homo sapiens] 32 2.6
gi|14550405 postreplication repair protein hRAD18p [Homo sapiens] 31 4.4
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 31 4.4
gi|51243032 oxysterol-binding protein-like protein 8 isoform b [... 31 4.4
gi|18079218 oxysterol-binding protein-like protein 8 isoform a [... 31 4.4
gi|4759198 homer 1 [Homo sapiens] 30 5.7
gi|17402873 BRCA2 and CDKN1A-interacting protein isoform C [Homo... 30 5.7
>gi|201861813 fermitin family homolog 2 isoform 2 [Homo sapiens]
Length = 687
Score = 1399 bits (3622), Expect = 0.0
Identities = 687/687 (100%), Positives = 687/687 (100%)
Query: 1 MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60
MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD
Sbjct: 1 MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60
Query: 61 HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120
HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF
Sbjct: 61 HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120
Query: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180
KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS
Sbjct: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180
Query: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240
SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ
Sbjct: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240
Query: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW
Sbjct: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
Query: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG
Sbjct: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
Query: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420
KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ
Sbjct: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420
Query: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480
MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM
Sbjct: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480
Query: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD 540
ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD
Sbjct: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD 540
Query: 541 LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 600
LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL
Sbjct: 541 LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 600
Query: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGY 660
IRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGY
Sbjct: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGY 660
Query: 661 IFLSTRAKDQNESLDEEMFYKLTSGWV 687
IFLSTRAKDQNESLDEEMFYKLTSGWV
Sbjct: 661 IFLSTRAKDQNESLDEEMFYKLTSGWV 687
>gi|29789006 fermitin family homolog 2 isoform 1 [Homo sapiens]
Length = 680
Score = 1377 bits (3565), Expect = 0.0
Identities = 680/687 (98%), Positives = 680/687 (98%), Gaps = 7/687 (1%)
Query: 1 MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60
MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD
Sbjct: 1 MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60
Query: 61 HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120
HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF
Sbjct: 61 HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120
Query: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180
KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS
Sbjct: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180
Query: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240
SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ
Sbjct: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240
Query: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW
Sbjct: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
Query: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG
Sbjct: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
Query: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420
KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ
Sbjct: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420
Query: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480
MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM
Sbjct: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480
Query: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD 540
ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQ
Sbjct: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQ------ 534
Query: 541 LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 600
ITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL
Sbjct: 535 -ITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 593
Query: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGY 660
IRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGY
Sbjct: 594 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGY 653
Query: 661 IFLSTRAKDQNESLDEEMFYKLTSGWV 687
IFLSTRAKDQNESLDEEMFYKLTSGWV
Sbjct: 654 IFLSTRAKDQNESLDEEMFYKLTSGWV 680
>gi|201861823 fermitin family homolog 2 isoform 3 [Homo sapiens]
Length = 633
Score = 1286 bits (3327), Expect = 0.0
Identities = 631/631 (100%), Positives = 631/631 (100%)
Query: 1 MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60
MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD
Sbjct: 1 MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSD 60
Query: 61 HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120
HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF
Sbjct: 61 HALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVF 120
Query: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180
KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS
Sbjct: 121 KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYS 180
Query: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240
SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ
Sbjct: 181 SPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQ 240
Query: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW
Sbjct: 241 ALLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
Query: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG
Sbjct: 301 AILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
Query: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420
KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ
Sbjct: 361 KTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQ 420
Query: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480
MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM
Sbjct: 421 MNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTM 480
Query: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD 540
ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD
Sbjct: 481 ADSSYNLEVQNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRD 540
Query: 541 LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 600
LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL
Sbjct: 541 LITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRL 600
Query: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMV 631
IRMDASTGDAIKTWRFSNMKQWNVNWEIKMV
Sbjct: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMV 631
>gi|116686114 kindlin-1 [Homo sapiens]
Length = 677
Score = 876 bits (2263), Expect = 0.0
Identities = 429/676 (63%), Positives = 535/676 (79%), Gaps = 18/676 (2%)
Query: 17 TWELSVHVTDLN----RDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWL 72
+WEL V V N +DVTLRV+G++H+GGVMLKLVE++++ +DWSD ALWWE+K WL
Sbjct: 11 SWELVVRVDHPNEEQQKDVTLRVSGDLHVGGVMLKLVEQINISQDWSDFALWWEQKHCWL 70
Query: 73 LKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNI 132
LKTHWTLDKYG+QADAKL FTPQHK+LRL+LPN+K V+++V+FS VFKAVSDICK NI
Sbjct: 71 LKTHWTLDKYGVQADAKLLFTPQHKMLRLRLPNLKMVRLRVSFSAVVFKAVSDICKILNI 130
Query: 133 RHPEELSLLKKPRDPTKKKKKKLDDQSE---DEALELEGPLITPGSGSIYSSPGLYSKTM 189
R EELSLLK D KKKKKK + E ++ L LE GS SPGLYSKTM
Sbjct: 131 RRSEELSLLKPSGDYFKKKKKKDKNNKEPIIEDILNLESSPTASGSS---VSPGLYSKTM 187
Query: 190 TPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQALLDKAKIN 249
TP YD +G+P S T WF DS L+E N ILA SQP SPE LA M++P++L+DKAK+N
Sbjct: 188 TPIYDPINGTPASSTMTWFSDSPLTEQNCSILAFSQPPQSPEALADMYQPRSLVDKAKLN 247
Query: 250 QGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIEC 309
GWLDSSRSLMEQ ++E+E LLLRFKYYSFFDLNPKYDA+RINQLYEQA+WAILLEEI+C
Sbjct: 248 AGWLDSSRSLMEQGIQEDEQLLLRFKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDC 307
Query: 310 TEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDI 369
TEEEM++FAALQYHI+KLS +++E + EVDE++AALS+LE+TLEGGK ++L DI
Sbjct: 308 TEEEMLIFAALQYHISKLS-LSAETQDFAGESEVDEIEAALSNLEVTLEGGKADSLLEDI 366
Query: 370 TSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVT 429
T IP+LAD +K+F+PKKL K +KQYW FKDTSI+ +K+KE G P ++NLRGCEV
Sbjct: 367 TDIPKLADNLKLFRPKKLLPKAFKQYWFIFKDTSIAYFKNKELEQGEPLEKLNLRGCEVV 426
Query: 430 PDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMADSSYNLEV 489
PDVN++G+KF IKLLIPVA+GMNE++LRCD+E QYA WMAAC LASKGKTMADSSY EV
Sbjct: 427 PDVNVAGRKFGIKLLIPVADGMNEMYLRCDHENQYAQWMAACMLASKGKTMADSSYQPEV 486
Query: 490 QNILSFLKMQHLNPDPQLIPEQITTDITPECLVSPRYLKKYKNKQPGYIRDLITARILEA 549
NILSFL+M++ N Q+ D+ PEC VSPR K++K+KQ + ARILEA
Sbjct: 487 LNILSFLRMKNRNSASQVASSLENMDMNPECFVSPRCAKRHKSKQ-------LAARILEA 539
Query: 550 HQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAYNRLIRMDASTGD 609
HQNVAQM L+EAK+RFIQAWQSLPEFG+T+++ RF+G KK++++G++YNRLI++DA+TG
Sbjct: 540 HQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLVRFKGSKKDDILGVSYNRLIKIDAATGI 599
Query: 610 AIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKD 669
+ TWRF+N+KQWNVNWE + V +EF V +F C DCK+VHE+IGGYIFLSTR+KD
Sbjct: 600 PVTTWRFTNIKQWNVNWETRQVVIEFDQNVFTAFTCLSADCKIVHEYIGGYIFLSTRSKD 659
Query: 670 QNESLDEEMFYKLTSG 685
QNE+LDE++F+KLT G
Sbjct: 660 QNETLDEDLFHKLTGG 675
>gi|28626504 fermitin family homolog 3 short form [Homo sapiens]
Length = 663
Score = 732 bits (1889), Expect = 0.0
Identities = 362/688 (52%), Positives = 496/688 (72%), Gaps = 38/688 (5%)
Query: 5 GIRMPDGCYADGTWELSVHVTDLNRD---VTLRVTGEVHIGGVMLKLVEKLDVKKDWSDH 61
G++ G Y D +WEL V V + + + VTLRVTGE HIGGV+LK+VE+++ K+DWSDH
Sbjct: 3 GMKTASGDYIDSSWELRVFVGEEDPEAESVTLRVTGESHIGGVLLKIVEQINRKQDWSDH 62
Query: 62 ALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFK 121
A+WWE+KR WLL+THWTLDKYGI ADA+L F PQH+ + L+LPN + ++++ +FS +F+
Sbjct: 63 AIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRALRLRASFSQPLFQ 122
Query: 122 AVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSS 181
AV+ IC+ +IRHPEELSLL R P KK+KKK + + E+E +L ++ G +
Sbjct: 123 AVAAICRLLSIRHPEELSLL---RAPEKKEKKKKEKEPEEELYDLSKVVLAGGV-----A 174
Query: 182 PGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQA 241
P L+ G P A F DSA +E +L+ QP P +L ++ +P +
Sbjct: 175 PALFR-----------GMP-----AHFSDSAQTEACYHMLSRPQPPPDPLLLQRLPRPSS 218
Query: 242 LLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWA 301
L DK +++ WLDSSR LM+Q +K +AL LRFKYYSFFDL+PK D +R+ QLYEQA+W
Sbjct: 219 LSDKTQLHSRWLDSSRCLMQQGIKAGDALWLRFKYYSFFDLDPKTDPVRLTQLYEQARWD 278
Query: 302 ILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGK 361
+LLEEI+CTEEEMM+FAALQYHINKLS +D +D++D ALS+LE+ LEG
Sbjct: 279 LLLEEIDCTEEEMMVFAALQYHINKLSQSGEVGEPAGTDPGLDDLDVALSNLEVKLEGSA 338
Query: 362 TSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQM 421
+ +L +T+IPEL D++++F+P+KLTLKGY+Q+W FK+T++S YKS++E+ G P Q+
Sbjct: 339 PTDVLDSLTTIPELKDHLRIFRPRKLTLKGYRQHWVVFKETTLSYYKSQDEAPGDPIQQL 398
Query: 422 NLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMA 481
NL+GCEV PDVN+SGQKF IKLL+P EGM+EI+LRC +E+QYA WMA CRLASKG+TMA
Sbjct: 399 NLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYARWMAGCRLASKGRTMA 458
Query: 482 DSSYNLEVQNILSFLKMQHLNP----DPQLIPEQITTDITPECLVSPRYLKKYKNKQPGY 537
DSSY EVQ IL+FL +Q + P+ + P LV+PR+ +K+K KQ
Sbjct: 459 DSSYTSEVQAILAFLSLQRTGSGGPGNHPHGPDASAEGLNPYGLVAPRFQRKFKAKQ--- 515
Query: 538 IRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELIGIAY 597
+T RILEAHQNVAQ+SL EA++RFIQAWQSLP+FGI++ + RF+G +K+E++GIA
Sbjct: 516 ----LTPRILEAHQNVAQLSLAEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIAN 571
Query: 598 NRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFI 657
NRLIR+D + GD +KTWRFSNM+QWNVNW+I+ V +EF + + ++F C C++VHE+I
Sbjct: 572 NRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYI 631
Query: 658 GGYIFLSTRAKDQNESLDEEMFYKLTSG 685
GGYIFLSTR + + E LDE++F +LT G
Sbjct: 632 GGYIFLSTRERARGEELDEDLFLQLTGG 659
>gi|41281905 fermitin family homolog 3 long form [Homo sapiens]
Length = 667
Score = 726 bits (1874), Expect = 0.0
Identities = 362/692 (52%), Positives = 496/692 (71%), Gaps = 42/692 (6%)
Query: 5 GIRMPDGCYADGTWELSVHVTDLNRD---VTLRVTGEVHIGGVMLKLVEKLDVKKDWSDH 61
G++ G Y D +WEL V V + + + VTLRVTGE HIGGV+LK+VE+++ K+DWSDH
Sbjct: 3 GMKTASGDYIDSSWELRVFVGEEDPEAESVTLRVTGESHIGGVLLKIVEQINRKQDWSDH 62
Query: 62 ALWWEKKRTWLLKTHWTLDKYGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFK 121
A+WWE+KR WLL+THWTLDKYGI ADA+L F PQH+ + L+LPN + ++++ +FS +F+
Sbjct: 63 AIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRALRLRASFSQPLFQ 122
Query: 122 AVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLITPGSGSIYSS 181
AV+ IC+ +IRHPEELSLL R P KK+KKK + + E+E +L ++ G +
Sbjct: 123 AVAAICRLLSIRHPEELSLL---RAPEKKEKKKKEKEPEEELYDLSKVVLAGGV-----A 174
Query: 182 PGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQA 241
P L+ G P A F DSA +E +L+ QP P +L ++ +P +
Sbjct: 175 PALFR-----------GMP-----AHFSDSAQTEACYHMLSRPQPPPDPLLLQRLPRPSS 218
Query: 242 LLDKAKINQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWA 301
L DK +++ WLDSSR LM+Q +K +AL LRFKYYSFFDL+PK D +R+ QLYEQA+W
Sbjct: 219 LSDKTQLHSRWLDSSRCLMQQGIKAGDALWLRFKYYSFFDLDPKTDPVRLTQLYEQARWD 278
Query: 302 ILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGK 361
+LLEEI+CTEEEMM+FAALQYHINKLS +D +D++D ALS+LE+ LEG
Sbjct: 279 LLLEEIDCTEEEMMVFAALQYHINKLSQSGEVGEPAGTDPGLDDLDVALSNLEVKLEGSA 338
Query: 362 TSTILGDITSIPELADYIKVFK----PKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTP 417
+ +L +T+IPEL D++++F+ P+KLTLKGY+Q+W FK+T++S YKS++E+ G P
Sbjct: 339 PTDVLDSLTTIPELKDHLRIFRIPRRPRKLTLKGYRQHWVVFKETTLSYYKSQDEAPGDP 398
Query: 418 AHQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKG 477
Q+NL+GCEV PDVN+SGQKF IKLL+P EGM+EI+LRC +E+QYA WMA CRLASKG
Sbjct: 399 IQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYARWMAGCRLASKG 458
Query: 478 KTMADSSYNLEVQNILSFLKMQHLNP----DPQLIPEQITTDITPECLVSPRYLKKYKNK 533
+TMADSSY EVQ IL+FL +Q + P+ + P LV+PR+ +K+K K
Sbjct: 459 RTMADSSYTSEVQAILAFLSLQRTGSGGPGNHPHGPDASAEGLNPYGLVAPRFQRKFKAK 518
Query: 534 QPGYIRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKKEELI 593
Q +T RILEAHQNVAQ+SL EA++RFIQAWQSLP+FGI++ + RF+G +K+E++
Sbjct: 519 Q-------LTPRILEAHQNVAQLSLAEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEIL 571
Query: 594 GIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVV 653
GIA NRLIR+D + GD +KTWRFSNM+QWNVNW+I+ V +EF + + ++F C C++V
Sbjct: 572 GIANNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIV 631
Query: 654 HEFIGGYIFLSTRAKDQNESLDEEMFYKLTSG 685
HE+IGGYIFLSTR + + E LDE++F +LT G
Sbjct: 632 HEYIGGYIFLSTRERARGEELDEDLFLQLTGG 663
>gi|223029410 talin 1 [Homo sapiens]
Length = 2541
Score = 68.9 bits (167), Expect = 1e-11
Identities = 42/150 (28%), Positives = 80/150 (53%), Gaps = 8/150 (5%)
Query: 527 LKKYKNKQPGYIRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIA--RF 584
LK + K+ Y++ +I +AH+N QMS IEAK+R+++ +SL +G++ F+ +
Sbjct: 262 LKDFLPKE--YVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKM 319
Query: 585 QGGKK--EELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLS 642
+G K L+GI ++R+D T + I+ W +N+K+W + K T++F D
Sbjct: 320 KGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAAS--PKSFTLDFGDYQDGY 377
Query: 643 FICTEVDCKVVHEFIGGYIFLSTRAKDQNE 672
+ + + + + I GYI + + K +
Sbjct: 378 YSVQTTEGEQIAQLIAGYIDIILKKKKSKD 407
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/73 (36%), Positives = 39/73 (53%)
Query: 252 WLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTE 311
WLD R+L EQ V+E+E LLLR K++ D +++N LY QA+ IL +
Sbjct: 173 WLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSF 232
Query: 312 EEMMMFAALQYHI 324
++ FA Q I
Sbjct: 233 DKACEFAGFQCQI 245
>gi|156938343 talin 2 [Homo sapiens]
Length = 2542
Score = 61.6 bits (148), Expect = 2e-09
Identities = 33/132 (25%), Positives = 71/132 (53%), Gaps = 6/132 (4%)
Query: 545 RILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIA--RFQGGKK--EELIGIAYNRL 600
RI + H+N +MS IEAK+++++ +SL +G++ F+ + +G K L+GI + +
Sbjct: 281 RIFQEHKNCGEMSEIEAKVKYVKLARSLRTYGVSFFLVKEKMKGKNKLVPRLLGITKDSV 340
Query: 601 IRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGY 660
+R+D T + ++ W + +K+W + K T++F + + + + + + I GY
Sbjct: 341 MRVDEKTKEVLQEWPLTTVKRWAAS--PKSFTLDFGEYQESYYSVQTTEGEQISQLIAGY 398
Query: 661 IFLSTRAKDQNE 672
I + + K +
Sbjct: 399 IDIILKKKQSKD 410
Score = 45.8 bits (107), Expect = 1e-04
Identities = 31/84 (36%), Positives = 42/84 (50%), Gaps = 4/84 (4%)
Query: 245 KAKINQ----GWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKW 300
KAK++ WLD SR+ EQ V ENE LLLR K++ D +++N LY QA+
Sbjct: 164 KAKLHTDDDLNWLDHSRTFREQGVDENETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARD 223
Query: 301 AILLEEIECTEEEMMMFAALQYHI 324
IL + E+ F Q I
Sbjct: 224 DILNGSHPVSFEKACEFGGFQAQI 247
>gi|50897850 KIAA1914 protein isoform 1 [Homo sapiens]
Length = 818
Score = 40.4 bits (93), Expect = 0.006
Identities = 30/121 (24%), Positives = 51/121 (42%), Gaps = 10/121 (8%)
Query: 359 GGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPA 418
G K ST L + E + Y+ V L +K WC+ +D + Y+ + S
Sbjct: 340 GRKKSTSLEPVERSLETSSYLNV-----LVNSQWKSRWCSVRDNHLHFYQDRNRSK-VAQ 393
Query: 419 HQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGK 478
++L GCEV PD + ++ ++L +G L + ++ HW+ S K
Sbjct: 394 QPLSLVGCEVVPDPS-PDHLYSFRIL---HKGEELAKLEAKSSEEMGHWLGLLLSESGSK 449
Query: 479 T 479
T
Sbjct: 450 T 450
>gi|24308338 KIAA1914 protein isoform 2 [Homo sapiens]
Length = 814
Score = 40.4 bits (93), Expect = 0.006
Identities = 30/121 (24%), Positives = 51/121 (42%), Gaps = 10/121 (8%)
Query: 359 GGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPA 418
G K ST L + E + Y+ V L +K WC+ +D + Y+ + S
Sbjct: 340 GRKKSTSLEPVERSLETSSYLNV-----LVNSQWKSRWCSVRDNHLHFYQDRNRSK-VAQ 393
Query: 419 HQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGK 478
++L GCEV PD + ++ ++L +G L + ++ HW+ S K
Sbjct: 394 QPLSLVGCEVVPDPS-PDHLYSFRIL---HKGEELAKLEAKSSEEMGHWLGLLLSESGSK 449
Query: 479 T 479
T
Sbjct: 450 T 450
>gi|197382472 actin filament associated protein 1 isoform a [Homo
sapiens]
Length = 814
Score = 37.0 bits (84), Expect = 0.061
Identities = 24/100 (24%), Positives = 46/100 (46%), Gaps = 6/100 (6%)
Query: 379 IKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVT-PDVNISGQ 437
I F +K + + C KDT + CYKS ++ P ++ L+GC +T + +
Sbjct: 156 ICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQ--PQMELPLQGCNITYIPKDSKKK 213
Query: 438 KFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKG 477
K +K+ +G + + L +++Q W+ + A G
Sbjct: 214 KHELKI---TQQGTDPLVLAVQSKEQAEQWLKVIKEAYSG 250
Score = 30.0 bits (66), Expect = 7.4
Identities = 19/77 (24%), Positives = 33/77 (42%), Gaps = 5/77 (6%)
Query: 392 YKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGM 451
+++ WC KD + +K + + T + LRGCEV P ++ S +LL G
Sbjct: 362 WRERWCRVKDNKLIFHKDRTDLK-THIVSIPLRGCEVIPGLD-SKHPLTFRLL---RNGQ 416
Query: 452 NEIWLRCDNEKQYAHWM 468
L + + W+
Sbjct: 417 EVAVLEASSSEDMGRWI 433
>gi|40807504 actin filament associated protein 1 [Homo sapiens]
Length = 730
Score = 37.0 bits (84), Expect = 0.061
Identities = 24/100 (24%), Positives = 46/100 (46%), Gaps = 6/100 (6%)
Query: 379 IKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVT-PDVNISGQ 437
I F +K + + C KDT + CYKS ++ P ++ L+GC +T + +
Sbjct: 156 ICAFLLRKKRFGQWTKLLCVIKDTKLLCYKSSKDQQ--PQMELPLQGCNITYIPKDSKKK 213
Query: 438 KFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKG 477
K +K+ +G + + L +++Q W+ + A G
Sbjct: 214 KHELKI---TQQGTDPLVLAVQSKEQAEQWLKVIKEAYSG 250
Score = 30.0 bits (66), Expect = 7.4
Identities = 19/77 (24%), Positives = 33/77 (42%), Gaps = 5/77 (6%)
Query: 392 YKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVAEGM 451
+++ WC KD + +K + + T + LRGCEV P ++ S +LL G
Sbjct: 362 WRERWCRVKDNKLIFHKDRTDLK-THIVSIPLRGCEVIPGLD-SKHPLTFRLL---RNGQ 416
Query: 452 NEIWLRCDNEKQYAHWM 468
L + + W+
Sbjct: 417 EVAVLEASSSEDMGRWI 433
>gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]
Length = 1015
Score = 35.8 bits (81), Expect = 0.14
Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)
Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
K D ++ L+ Q K+ +LE +E +E+ LQ + + L + EV
Sbjct: 269 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 327
Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
+V LSD + T + ++GD TS+ E+ ++F P K+
Sbjct: 328 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 384
Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
TL + FKD+S +KEE H++ LR GC V+P+ +N+ G
Sbjct: 385 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 444
Query: 438 KFNIKLLIPVAEGMNEI 454
+L+ + +N +
Sbjct: 445 GLQRMVLVDLPGVINTV 461
>gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]
Length = 997
Score = 35.8 bits (81), Expect = 0.14
Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)
Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
K D ++ L+ Q K+ +LE +E +E+ LQ + + L + EV
Sbjct: 251 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 309
Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
+V LSD + T + ++GD TS+ E+ ++F P K+
Sbjct: 310 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 366
Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
TL + FKD+S +KEE H++ LR GC V+P+ +N+ G
Sbjct: 367 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 426
Query: 438 KFNIKLLIPVAEGMNEI 454
+L+ + +N +
Sbjct: 427 GLQRMVLVDLPGVINTV 443
>gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]
Length = 979
Score = 35.8 bits (81), Expect = 0.14
Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)
Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
K D ++ L+ Q K+ +LE +E +E+ LQ + + L + EV
Sbjct: 233 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 291
Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
+V LSD + T + ++GD TS+ E+ ++F P K+
Sbjct: 292 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 348
Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
TL + FKD+S +KEE H++ LR GC V+P+ +N+ G
Sbjct: 349 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 408
Query: 438 KFNIKLLIPVAEGMNEI 454
+L+ + +N +
Sbjct: 409 GLQRMVLVDLPGVINTV 425
>gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]
Length = 978
Score = 35.8 bits (81), Expect = 0.14
Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)
Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
K D ++ L+ Q K+ +LE +E +E+ LQ + + L + EV
Sbjct: 232 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 290
Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
+V LSD + T + ++GD TS+ E+ ++F P K+
Sbjct: 291 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 347
Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
TL + FKD+S +KEE H++ LR GC V+P+ +N+ G
Sbjct: 348 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 407
Query: 438 KFNIKLLIPVAEGMNEI 454
+L+ + +N +
Sbjct: 408 GLQRMVLVDLPGVINTV 424
>gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]
Length = 961
Score = 35.8 bits (81), Expect = 0.14
Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)
Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
K D ++ L+ Q K+ +LE +E +E+ LQ + + L + EV
Sbjct: 215 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 273
Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
+V LSD + T + ++GD TS+ E+ ++F P K+
Sbjct: 274 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 330
Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
TL + FKD+S +KEE H++ LR GC V+P+ +N+ G
Sbjct: 331 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 390
Query: 438 KFNIKLLIPVAEGMNEI 454
+L+ + +N +
Sbjct: 391 GLQRMVLVDLPGVINTV 407
>gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]
Length = 942
Score = 35.8 bits (81), Expect = 0.14
Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)
Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
K D ++ L+ Q K+ +LE +E +E+ LQ + + L + EV
Sbjct: 196 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 254
Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
+V LSD + T + ++GD TS+ E+ ++F P K+
Sbjct: 255 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 311
Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
TL + FKD+S +KEE H++ LR GC V+P+ +N+ G
Sbjct: 312 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 371
Query: 438 KFNIKLLIPVAEGMNEI 454
+L+ + +N +
Sbjct: 372 GLQRMVLVDLPGVINTV 388
>gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]
Length = 924
Score = 35.8 bits (81), Expect = 0.14
Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)
Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
K D ++ L+ Q K+ +LE +E +E+ LQ + + L + EV
Sbjct: 178 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 236
Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
+V LSD + T + ++GD TS+ E+ ++F P K+
Sbjct: 237 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 293
Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
TL + FKD+S +KEE H++ LR GC V+P+ +N+ G
Sbjct: 294 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 353
Query: 438 KFNIKLLIPVAEGMNEI 454
+L+ + +N +
Sbjct: 354 GLQRMVLVDLPGVINTV 370
>gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]
Length = 960
Score = 35.8 bits (81), Expect = 0.14
Identities = 47/197 (23%), Positives = 82/197 (41%), Gaps = 31/197 (15%)
Query: 285 KYDAIRINQLYEQAKWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVD 344
K D ++ L+ Q K+ +LE +E +E+ LQ + + L + EV
Sbjct: 214 KIDQLQEELLHTQLKYQRILERLEKENKELRKLV-LQKDDKGIHHRKLKKSLIDMYSEVL 272
Query: 345 EVDAALSDLEI---TLEGGKTSTILGDI----TSIPELADYIKVF----------KPKKL 387
+V LSD + T + ++GD TS+ E+ ++F P K+
Sbjct: 273 DV---LSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKV 329
Query: 388 TLKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLR-------GCEVTPD---VNISGQ 437
TL + FKD+S +KEE H++ LR GC V+P+ +N+ G
Sbjct: 330 TLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGP 389
Query: 438 KFNIKLLIPVAEGMNEI 454
+L+ + +N +
Sbjct: 390 GLQRMVLVDLPGVINTV 406
>gi|40805104 topoisomerase I binding, arginine/serine-rich [Homo
sapiens]
Length = 1045
Score = 33.9 bits (76), Expect = 0.52
Identities = 16/45 (35%), Positives = 27/45 (60%)
Query: 329 IMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDITSIP 373
I T N+LNN++K VD + + +E TL+ + ST + D+ + P
Sbjct: 968 IATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQP 1012
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 32.7 bits (73), Expect = 1.1
Identities = 23/71 (32%), Positives = 38/71 (53%), Gaps = 4/71 (5%)
Query: 252 WLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIR-INQ--LYEQAKWAILLEEIE 308
WL ++ + +QDVK+ L +F+ FF + + I+ I Q + Q K AIL +EI
Sbjct: 58 WLKLNKKVTQQDVKKENPLQFKFR-AKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIY 116
Query: 309 CTEEEMMMFAA 319
C E ++ A+
Sbjct: 117 CPPETAVLLAS 127
>gi|112420958 DNA-directed DNA polymerase nu [Homo sapiens]
Length = 900
Score = 32.3 bits (72), Expect = 1.5
Identities = 61/292 (20%), Positives = 111/292 (38%), Gaps = 59/292 (20%)
Query: 247 KINQGWLDSSRSLMEQDVKENEALLLR--------FKYYSFFDLNPKYDAIRINQLYEQA 298
K+N + +SSR+++ Q+V+EN L R K Y + L + I L
Sbjct: 380 KVNSTYGNSSRNIVNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVME 439
Query: 299 KWAILLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLE 358
AI + + E + ++ A L+ + + E L S+ ++ E+ L++ L
Sbjct: 440 SHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREI--LFGKLKLHLL 497
Query: 359 GGKTSTILGDITSIPELADYI----KVFKPKKLTLKGYKQYW---CTFKDTSISCYKSKE 411
+ S + P ++ + + P + Y+Q TF D ++C K
Sbjct: 498 SQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGS 557
Query: 412 ESS-----GT-----PAHQMNLRG-----CEVTPDVNISGQKFNIKLLIPVAEGMNEIWL 456
SS GT A N++G ++T N G++ I + P
Sbjct: 558 ISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISP---------- 607
Query: 457 RCDNEKQYAHWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHLNPDPQLI 508
A ++SKG T + ++ IL+ HL+ DP+L+
Sbjct: 608 ------------RAMFVSSKGHTFLAADFSQIELRILT-----HLSGDPELL 642
>gi|4505531 oxysterol binding protein [Homo sapiens]
Length = 807
Score = 31.6 bits (70), Expect = 2.6
Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 10/106 (9%)
Query: 389 LKGYKQYWCTFKDTSISCYKSKEESSGTPAHQMNLRGCEVTPDVNISGQKFNIKLLIPVA 448
+KGY++ W + +S Y+SK E T +NL +T + + + I
Sbjct: 102 IKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVEDSCN--------FIISN 153
Query: 449 EGMNEIWLRCDNEKQYAHWMAACRLASKG--KTMADSSYNLEVQNI 492
G L+ +E + W+ A LA K +A+S + + +++
Sbjct: 154 GGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESV 199
>gi|14550405 postreplication repair protein hRAD18p [Homo sapiens]
Length = 495
Score = 30.8 bits (68), Expect = 4.4
Identities = 31/123 (25%), Positives = 51/123 (41%), Gaps = 13/123 (10%)
Query: 48 LVEKLDVKKDWSDHALWWEKKRTWLLKTHWT-LDKYGIQADA---KLQFTPQHKLLRLQL 103
L+ D+KK +H L + + L+K H + Y Q DA K ++ ++
Sbjct: 250 LLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEIVQEIENIEK 309
Query: 104 PNMKYVKVKVNFSDRVF------KAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDD 157
M+ K+N S VF K + +I + +H E LL D +K KK+
Sbjct: 310 TRMRLEASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQLLV---DQARKGYKKIAG 366
Query: 158 QSE 160
S+
Sbjct: 367 MSQ 369
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 30.8 bits (68), Expect = 4.4
Identities = 25/106 (23%), Positives = 52/106 (49%), Gaps = 20/106 (18%)
Query: 84 IQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICK-------TFNIRHPE 136
+ A+AK++ + ++L L+ N K++K K DR+ + S + + IR+ +
Sbjct: 974 VTAEAKIK-KMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ 1032
Query: 137 ELSLL---------KKPRDPTKKKKKKLDDQS---EDEALELEGPL 170
E+ + +K R +K K+KLD ++ +D+ EL+ +
Sbjct: 1033 EVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078
>gi|51243032 oxysterol-binding protein-like protein 8 isoform b
[Homo sapiens]
Length = 847
Score = 30.8 bits (68), Expect = 4.4
Identities = 20/69 (28%), Positives = 35/69 (50%), Gaps = 8/69 (11%)
Query: 362 TSTILGDIT--SIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAH 419
T +L IT S+ +AD++K+ + TLK + + WC K + YK+ + +G
Sbjct: 94 TKELLSTITDPSVIVMADWLKI----RGTLKSWTKLWCVLKPGVLLIYKT--QKNGQWVG 147
Query: 420 QMNLRGCEV 428
+ L CE+
Sbjct: 148 TVLLNACEI 156
>gi|18079218 oxysterol-binding protein-like protein 8 isoform a
[Homo sapiens]
Length = 889
Score = 30.8 bits (68), Expect = 4.4
Identities = 20/69 (28%), Positives = 35/69 (50%), Gaps = 8/69 (11%)
Query: 362 TSTILGDIT--SIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSKEESSGTPAH 419
T +L IT S+ +AD++K+ + TLK + + WC K + YK+ + +G
Sbjct: 136 TKELLSTITDPSVIVMADWLKI----RGTLKSWTKLWCVLKPGVLLIYKT--QKNGQWVG 189
Query: 420 QMNLRGCEV 428
+ L CE+
Sbjct: 190 TVLLNACEI 198
>gi|4759198 homer 1 [Homo sapiens]
Length = 354
Score = 30.4 bits (67), Expect = 5.7
Identities = 46/198 (23%), Positives = 82/198 (41%), Gaps = 35/198 (17%)
Query: 188 TMTPTYDAHDG---SPLSPTSAWFGDSALSEGNPGILAVSQPITSPEILAKMFKPQALLD 244
T TP+ ++ G SPL+P S + E P + S+P P A F + +
Sbjct: 124 TSTPSQESAGGDLQSPLTPESI---NGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAIS 180
Query: 245 K-------------AKINQGWLDSSRSLMEQDVK----ENEALLLRFKYYSFFDLNPKYD 287
K AK+ L+S+ ++ + + + EA L + ++ + +
Sbjct: 181 KHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQAN 240
Query: 288 AI-----RINQLYEQAKWAILL--EEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSD 340
A+ +NQ ++ + + L EEIE ++E+ LQ + L+ E + N D
Sbjct: 241 AVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKD 300
Query: 341 KEVDEVDAALSDLEITLE 358
++ LSDLE LE
Sbjct: 301 -----LEGQLSDLEQRLE 313
>gi|17402873 BRCA2 and CDKN1A-interacting protein isoform C [Homo
sapiens]
Length = 292
Score = 30.4 bits (67), Expect = 5.7
Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 9/107 (8%)
Query: 254 DSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTEEE 313
DS + E+D +E + + F+ YS D + YD I+ +L +Q L + E
Sbjct: 41 DSDKEKDEEDEVIDEEVNIEFEAYSLSDND--YDGIK--KLLQQ-----LFLKAPVNTAE 91
Query: 314 MMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGG 360
+ Q HI + T + +N D + DEV +S L +T G
Sbjct: 92 LTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKG 138
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,701,176
Number of Sequences: 37866
Number of extensions: 1230239
Number of successful extensions: 3599
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 3555
Number of HSP's gapped (non-prelim): 67
length of query: 687
length of database: 18,247,518
effective HSP length: 109
effective length of query: 578
effective length of database: 14,120,124
effective search space: 8161431672
effective search space used: 8161431672
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.