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Search of human proteins with 20149588
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20149588 Ras association domain family 1 isoform A [Homo
sapiens]
(340 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20149588 Ras association domain family 1 isoform A [Homo sapi... 702 0.0
gi|25777684 Ras association domain family 1 isoform D [Homo sapi... 693 0.0
gi|25777682 Ras association domain family 1 isoform C [Homo sapi... 442 e-124
gi|25777680 Ras association domain family 1 isoform B [Homo sapi... 378 e-105
gi|32996731 Ras association (RalGDS/AF-6) domain family 5 isofor... 275 6e-74
gi|32996735 Ras association (RalGDS/AF-6) domain family 5 isofor... 228 8e-60
gi|32996733 Ras association (RalGDS/AF-6) domain family 5 isofor... 181 6e-46
gi|30039698 Ras association (RalGDS/AF-6) domain family member 3... 167 1e-41
gi|23510360 Ras association domain family 4 [Homo sapiens] 62 7e-10
gi|25777677 Ras association domain family 2 [Homo sapiens] 62 1e-09
gi|7661964 Ras association domain family 2 [Homo sapiens] 62 1e-09
gi|41393610 Ras association (RalGDS/AF-6) domain family 6 isofor... 59 6e-09
gi|29789443 Ras association (RalGDS/AF-6) domain family 6 isofor... 59 6e-09
gi|28557781 protein kinase C, eta [Homo sapiens] 56 4e-08
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 56 4e-08
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 56 4e-08
gi|133908623 protein kinase C, iota [Homo sapiens] 56 5e-08
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 55 9e-08
gi|5031689 protein kinase D3 [Homo sapiens] 55 1e-07
gi|13384594 protein kinase C, gamma [Homo sapiens] 54 2e-07
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 54 2e-07
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 54 2e-07
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 54 2e-07
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 53 4e-07
gi|47157325 protein kinase C, delta [Homo sapiens] 53 4e-07
gi|31377782 protein kinase C, delta [Homo sapiens] 53 4e-07
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 53 4e-07
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 53 4e-07
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 53 4e-07
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 53 4e-07
>gi|20149588 Ras association domain family 1 isoform A [Homo
sapiens]
Length = 340
Score = 702 bits (1812), Expect = 0.0
Identities = 340/340 (100%), Positives = 340/340 (100%)
Query: 1 MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA 60
MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA
Sbjct: 1 MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA 60
Query: 61 THTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTNVD 120
THTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTNVD
Sbjct: 61 THTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTNVD 120
Query: 121 EPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSK 180
EPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSK
Sbjct: 121 EPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSK 180
Query: 181 KPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPR 240
KPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPR
Sbjct: 181 KPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPR 240
Query: 241 KFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMPE 300
KFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMPE
Sbjct: 241 KFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMPE 300
Query: 301 LHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 340
LHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG
Sbjct: 301 LHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 340
>gi|25777684 Ras association domain family 1 isoform D [Homo
sapiens]
Length = 344
Score = 693 bits (1789), Expect = 0.0
Identities = 339/344 (98%), Positives = 339/344 (98%), Gaps = 4/344 (1%)
Query: 1 MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA 60
MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA
Sbjct: 1 MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPA 60
Query: 61 THTWCDLCGDFIWGVVRKGLQCAH----CKFTCHYRCRALVCLDCCGPRDLGWEPAVERD 116
THTWCDLCGDFIWGVVRKGLQCA CKFTCHYRCRALVCLDCCGPRDLGWEPAVERD
Sbjct: 61 THTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERD 120
Query: 117 TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV 176
TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV
Sbjct: 121 TNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSV 180
Query: 177 PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV 236
PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV
Sbjct: 181 PSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVV 240
Query: 237 DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF 296
DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF
Sbjct: 241 DDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAF 300
Query: 297 SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 340
SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG
Sbjct: 301 SMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 344
>gi|25777682 Ras association domain family 1 isoform C [Homo
sapiens]
Length = 270
Score = 442 bits (1138), Expect = e-124
Identities = 221/221 (100%), Positives = 221/221 (100%)
Query: 120 DEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSS 179
DEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSS
Sbjct: 50 DEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSS 109
Query: 180 KKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDP 239
KKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDP
Sbjct: 110 KKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDP 169
Query: 240 RKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMP 299
RKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMP
Sbjct: 170 RKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMP 229
Query: 300 ELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 340
ELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG
Sbjct: 230 ELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG 270
>gi|25777680 Ras association domain family 1 isoform B [Homo
sapiens]
Length = 189
Score = 378 bits (970), Expect = e-105
Identities = 189/189 (100%), Positives = 189/189 (100%)
Query: 152 MSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAV 211
MSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAV
Sbjct: 1 MSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAV 60
Query: 212 KHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLL 271
KHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLL
Sbjct: 61 KHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLL 120
Query: 272 AGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQ 331
AGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQ
Sbjct: 121 AGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQ 180
Query: 332 EALHACPLG 340
EALHACPLG
Sbjct: 181 EALHACPLG 189
>gi|32996731 Ras association (RalGDS/AF-6) domain family 5 isoform A
[Homo sapiens]
Length = 418
Score = 275 bits (702), Expect = 6e-74
Identities = 147/297 (49%), Positives = 195/297 (65%), Gaps = 17/297 (5%)
Query: 49 GRGHRFQ----PAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGP 104
G GH F P GP WCDLCG V+R+ L+C +CKFTCH CR+L+ LDC
Sbjct: 120 GEGHCFAELVLPGGPG---WCDLCGR---EVLRQALRCTNCKFTCHPECRSLIQLDCSQQ 173
Query: 105 RDLGWEPAVERDT-------NVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKD 157
L + T NV +PVE + EI+QKI YN + + L M L++D
Sbjct: 174 EGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSED 233
Query: 158 GSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVL 217
G+YTGFIKV LKL RPV+VP+ +P S+ DA + + +RTSFYLP DA+K LH+
Sbjct: 234 GTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHIS 293
Query: 218 SRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDK 277
S T EVI+ LL+KF+VVD+P+KFALF+R + GQV +KL ++PL LRLLAGP +
Sbjct: 294 STTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTE 353
Query: 278 ALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEAL 334
LSFVLKEN++GEV WDAFS+PEL NFL IL++EE++ ++Q+ +KY RQK++EAL
Sbjct: 354 VLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEAL 410
>gi|32996735 Ras association (RalGDS/AF-6) domain family 5 isoform C
[Homo sapiens]
Length = 265
Score = 228 bits (580), Expect = 8e-60
Identities = 116/217 (53%), Positives = 157/217 (72%)
Query: 118 NVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVP 177
NV +PVE + EI+QKI YN + + L M L++DG+YTGFIKV LKL RPV+VP
Sbjct: 41 NVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVP 100
Query: 178 SSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVD 237
+ +P S+ DA + + +RTSFYLP DA+K LH+ S T EVI+ LL+KF+VVD
Sbjct: 101 AGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVD 160
Query: 238 DPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFS 297
+P+KFALF+R + GQV +KL ++PL LRLLAGP + LSFVLKEN++GEV WDAFS
Sbjct: 161 NPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFS 220
Query: 298 MPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEAL 334
+PEL NFL IL++EE++ ++Q+ +KY RQK++EAL
Sbjct: 221 IPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEAL 257
>gi|32996733 Ras association (RalGDS/AF-6) domain family 5 isoform B
[Homo sapiens]
Length = 336
Score = 181 bits (460), Expect = 6e-46
Identities = 101/217 (46%), Positives = 132/217 (60%), Gaps = 17/217 (7%)
Query: 49 GRGHRFQ----PAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGP 104
G GH F P GP WCDLCG V+R+ L+C +CKFTCH CR+L+ LDC
Sbjct: 120 GEGHCFAELVLPGGPG---WCDLCGR---EVLRQALRCTNCKFTCHPECRSLIQLDCSQQ 173
Query: 105 RDLGWEPAVERDT-------NVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKD 157
L + T NV +PVE + EI+QKI YN + + L M L++D
Sbjct: 174 EGLSRDRPSPESTLTVTFSQNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSED 233
Query: 158 GSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVL 217
G+YTGFIKV LKL RPV+VP+ +P S+ DA + + +RTSFYLP DA+K LH+
Sbjct: 234 GTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHIS 293
Query: 218 SRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQV 254
S T EVI+ LL+KF+VVD+P+KFALF+R + GQV
Sbjct: 294 STTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQV 330
>gi|30039698 Ras association (RalGDS/AF-6) domain family member 3
[Homo sapiens]
Length = 238
Score = 167 bits (423), Expect = 1e-41
Identities = 95/207 (45%), Positives = 127/207 (61%), Gaps = 26/207 (12%)
Query: 130 LSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRP--VSVPSSKKPPSLQD 187
LS+ EI++K+ +YN + L M+LN +G YTGFIKVQ++L +P S S K PS
Sbjct: 49 LSKEEIKEKVHKYNLAVTDKLKMTLNSNGIYTGFIKVQMELCKPPQTSPNSGKLSPS--- 105
Query: 188 ARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFER 247
+ LH+ S EVIEALL+KFLV + P KFAL++R
Sbjct: 106 -------------------SNGCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFALYKR 146
Query: 248 AERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRI 307
R QVY KL D E PL LRL+AGP LSFVL+E++ GE W+AFS+PEL NFLRI
Sbjct: 147 CHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHEIGE--WEAFSLPELQNFLRI 204
Query: 308 LQREEEEHLRQILQKYSYCRQKIQEAL 334
L +EE+E L+ + ++Y+ RQK++EAL
Sbjct: 205 LDKEEDEQLQNLKRRYTAYRQKLEEAL 231
>gi|23510360 Ras association domain family 4 [Homo sapiens]
Length = 321
Score = 62.0 bits (149), Expect = 7e-10
Identities = 53/173 (30%), Positives = 78/173 (45%), Gaps = 32/173 (18%)
Query: 190 RGPGRGTSVRR------------RTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVV 236
R PG +RR +TS + P +V ++ V S +V+ LL KF V
Sbjct: 154 RAPGEAQRIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVE 213
Query: 237 DDPRKFALF---ERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSG---- 289
D P +FAL+ E ER KL D E PL R+L GP +K L E D G
Sbjct: 214 DGPSEFALYIVHESGER------TKLKDCEYPLISRILHGPCEKIARIFLMEADLGVEVP 267
Query: 290 --EVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCR----QKIQEALHA 336
+ F MP L +F+ L+ EEE + ++ K+ R Q++++ + A
Sbjct: 268 HEVAQYIKFEMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMLQRLEQLVEA 320
>gi|25777677 Ras association domain family 2 [Homo sapiens]
Length = 326
Score = 61.6 bits (148), Expect = 1e-09
Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 10/147 (6%)
Query: 195 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQ 253
G +TS + P +V ++ + S +V++ LL KF + + +FAL+ H
Sbjct: 173 GHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVV---HTS 229
Query: 254 VYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDS-GEVNWDA-----FSMPELHNFLRI 307
+KL + PL R+L GP ++ L E D EV +D F MP L +F++
Sbjct: 230 GEKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQK 289
Query: 308 LQREEEEHLRQILQKYSYCRQKIQEAL 334
LQ EE+ ++++++KY+ R I++ L
Sbjct: 290 LQEEEDREVKKLMRKYTVLRLMIRQRL 316
>gi|7661964 Ras association domain family 2 [Homo sapiens]
Length = 326
Score = 61.6 bits (148), Expect = 1e-09
Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 10/147 (6%)
Query: 195 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQ 253
G +TS + P +V ++ + S +V++ LL KF + + +FAL+ H
Sbjct: 173 GHFYNHKTSVFTPAYGSVTNVRINSTMTTPQVLKLLLNKFKIENSAEEFALYVV---HTS 229
Query: 254 VYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDS-GEVNWDA-----FSMPELHNFLRI 307
+KL + PL R+L GP ++ L E D EV +D F MP L +F++
Sbjct: 230 GEKQKLKATDYPLIARILQGPCEQISKVFLMEKDQVEEVTYDVAQYIKFEMPVLKSFIQK 289
Query: 308 LQREEEEHLRQILQKYSYCRQKIQEAL 334
LQ EE+ ++++++KY+ R I++ L
Sbjct: 290 LQEEEDREVKKLMRKYTVLRLMIRQRL 316
>gi|41393610 Ras association (RalGDS/AF-6) domain family 6 isoform b
[Homo sapiens]
Length = 369
Score = 58.9 bits (141), Expect = 6e-09
Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 15/139 (10%)
Query: 195 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFAL---FERAER 250
G TS ++P ++ + V S R EVI+ LL+KF + + P+ FAL F E+
Sbjct: 215 GHFYNHETSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATGEQ 274
Query: 251 HGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDA-----FSMPELHNFL 305
R+L + PL RLL GPS+K L + D+ E++ D F L + L
Sbjct: 275 ------RRLKKTDIPLLQRLLQGPSEKNARIFLMDKDAEEISSDVAQYINFHFSLLESIL 328
Query: 306 RILQREEEEHLRQILQKYS 324
+ L EE+ +++I+ K++
Sbjct: 329 QRLNEEEKREIQRIVTKFN 347
>gi|29789443 Ras association (RalGDS/AF-6) domain family 6 isoform a
[Homo sapiens]
Length = 337
Score = 58.9 bits (141), Expect = 6e-09
Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 15/139 (10%)
Query: 195 GTSVRRRTSFYLPK-DAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFAL---FERAER 250
G TS ++P ++ + V S R EVI+ LL+KF + + P+ FAL F E+
Sbjct: 183 GHFYNHETSIFIPAFESETKVRVNSNMRTEEVIKQLLQKFKIENSPQDFALHIIFATGEQ 242
Query: 251 HGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDA-----FSMPELHNFL 305
R+L + PL RLL GPS+K L + D+ E++ D F L + L
Sbjct: 243 ------RRLKKTDIPLLQRLLQGPSEKNARIFLMDKDAEEISSDVAQYINFHFSLLESIL 296
Query: 306 RILQREEEEHLRQILQKYS 324
+ L EE+ +++I+ K++
Sbjct: 297 QRLNEEEKREIQRIVTKFN 315
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 56.2 bits (134), Expect = 4e-08
Identities = 22/50 (44%), Positives = 30/50 (60%)
Query: 52 HRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
H+F T+CD CG +WG++R+GLQC CK H RC+A V +C
Sbjct: 246 HKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNC 295
Score = 44.7 bits (104), Expect = 1e-04
Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 1/52 (1%)
Query: 51 GHRFQPAGPATHTWCDLCGDFIWGVV-RKGLQCAHCKFTCHYRCRALVCLDC 101
GH+F T+C C +FIWGV ++G QC C H RC L+ C
Sbjct: 171 GHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTAC 222
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 56.2 bits (134), Expect = 4e-08
Identities = 21/53 (39%), Positives = 30/53 (56%)
Query: 49 GRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
G H FQ T+CD C F+WGV+++G +C C CH +C+ LV +C
Sbjct: 504 GFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFEC 556
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 56.2 bits (134), Expect = 4e-08
Identities = 21/53 (39%), Positives = 30/53 (56%)
Query: 49 GRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
G H FQ T+CD C F+WGV+++G +C C CH +C+ LV +C
Sbjct: 539 GFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFEC 591
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 55.8 bits (133), Expect = 5e-08
Identities = 27/73 (36%), Positives = 37/73 (50%), Gaps = 1/73 (1%)
Query: 44 RQLVPGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCG 103
R+L GH FQ C +C D IWG+ R+G +C +CK H +C LV ++ CG
Sbjct: 133 RKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIE-CG 191
Query: 104 PRDLGWEPAVERD 116
L EP + D
Sbjct: 192 RHSLPQEPVMPMD 204
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 55.1 bits (131), Expect = 9e-08
Identities = 32/89 (35%), Positives = 41/89 (46%), Gaps = 4/89 (4%)
Query: 44 RQLVPGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCG 103
R+L GH FQ +C C + IWG+ R+G +C +CK H RC LV L C
Sbjct: 123 RKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRK 182
Query: 104 PRDL---GWEPAVERDTNVDEPVEWETPD 129
D EP V+ D N D + E D
Sbjct: 183 HMDSVMPSQEPPVD-DKNEDADLPSEETD 210
>gi|5031689 protein kinase D3 [Homo sapiens]
Length = 890
Score = 54.7 bits (130), Expect = 1e-07
Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 1/80 (1%)
Query: 52 HRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGWEP 111
H F T C C + G+ R+G+QC CKF CH RC + V DC G EP
Sbjct: 272 HTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEP 331
Query: 112 AVERDTNVDEPVEWETPDLS 131
+ T+ D P++ + D++
Sbjct: 332 S-SLGTDTDIPMDIDNNDIN 350
Score = 50.4 bits (119), Expect = 2e-06
Identities = 19/43 (44%), Positives = 27/43 (62%)
Query: 63 TWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPR 105
T+CD CG+ +WG+VR+GL+C C H RC + +C G R
Sbjct: 166 TFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVR 208
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 54.3 bits (129), Expect = 2e-07
Identities = 22/54 (40%), Positives = 29/54 (53%)
Query: 50 RGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCG 103
+ H+F T+C C DFIWG+ ++GLQC C F H RC V +C G
Sbjct: 34 KSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPG 87
Score = 45.4 bits (106), Expect = 7e-05
Identities = 16/46 (34%), Positives = 29/46 (63%)
Query: 48 PGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRC 93
P H+F+ ++ T+CD CG ++G+V +G++C+ C+ H RC
Sbjct: 97 PRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRC 142
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 53.9 bits (128), Expect = 2e-07
Identities = 20/54 (37%), Positives = 31/54 (57%)
Query: 48 PGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
PG H FQ T+C+ C F+WG++++G +C C CH +C+ L+ L C
Sbjct: 491 PGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLAC 544
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 53.9 bits (128), Expect = 2e-07
Identities = 20/54 (37%), Positives = 31/54 (57%)
Query: 48 PGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
PG H FQ T+C+ C F+WG++++G +C C CH +C+ L+ L C
Sbjct: 491 PGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLAC 544
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 53.9 bits (128), Expect = 2e-07
Identities = 20/54 (37%), Positives = 31/54 (57%)
Query: 48 PGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
PG H FQ T+C+ C F+WG++++G +C C CH +C+ L+ L C
Sbjct: 490 PGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLAC 543
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 52.8 bits (125), Expect = 4e-07
Identities = 27/89 (30%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 13 LAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPATHTWCDLCGDFI 72
L P R G+G E + C+ +L H F T+CD C F+
Sbjct: 505 LHPPPRQGRGSFSREELTGYLLRASAICS---KLGLAFLHTFHEVTFRKPTFCDSCSGFL 561
Query: 73 WGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
WGV ++G +C C CH CR V ++C
Sbjct: 562 WGVTKQGYRCRECGLCCHKHCRDQVKVEC 590
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 52.8 bits (125), Expect = 4e-07
Identities = 21/52 (40%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Query: 52 HRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCG 103
HRF+ + T+CD CG +WG+V++GL+C C H++CR V + CG
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVA-NLCG 281
Score = 43.1 bits (100), Expect = 4e-04
Identities = 19/74 (25%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 50 RGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGW 109
+ H F T+C +C DF+WG+ ++G +C C H +C + C G
Sbjct: 157 KNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSR 216
Query: 110 EPAVERDT-NVDEP 122
+ +++ N+D P
Sbjct: 217 DTIFQKERFNIDMP 230
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 52.8 bits (125), Expect = 4e-07
Identities = 21/52 (40%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Query: 52 HRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCG 103
HRF+ + T+CD CG +WG+V++GL+C C H++CR V + CG
Sbjct: 231 HRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVA-NLCG 281
Score = 43.1 bits (100), Expect = 4e-04
Identities = 19/74 (25%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 50 RGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGW 109
+ H F T+C +C DF+WG+ ++G +C C H +C + C G
Sbjct: 157 KNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSR 216
Query: 110 EPAVERDT-NVDEP 122
+ +++ N+D P
Sbjct: 217 DTIFQKERFNIDMP 230
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 52.8 bits (125), Expect = 4e-07
Identities = 27/89 (30%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 13 LAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPATHTWCDLCGDFI 72
L P R G+G E + C+ +L H F T+CD C F+
Sbjct: 408 LHPPPRQGRGSFSREELTGYLLRASAICS---KLGLAFLHTFHEVTFRKPTFCDSCSGFL 464
Query: 73 WGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
WGV ++G +C C CH CR V ++C
Sbjct: 465 WGVTKQGYRCRECGLCCHKHCRDQVKVEC 493
>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
Length = 484
Score = 52.8 bits (125), Expect = 4e-07
Identities = 27/89 (30%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 13 LAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPATHTWCDLCGDFI 72
L P R G+G E + C+ +L H F T+CD C F+
Sbjct: 316 LHPPPRQGRGSFSREELTGYLLRASAICS---KLGLAFLHTFHEVTFRKPTFCDSCSGFL 372
Query: 73 WGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
WGV ++G +C C CH CR V ++C
Sbjct: 373 WGVTKQGYRCRECGLCCHKHCRDQVKVEC 401
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 52.8 bits (125), Expect = 4e-07
Identities = 27/89 (30%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 13 LAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPATHTWCDLCGDFI 72
L P R G+G E + C+ +L H F T+CD C F+
Sbjct: 471 LHPPPRQGRGSFSREELTGYLLRASAICS---KLGLAFLHTFHEVTFRKPTFCDSCSGFL 527
Query: 73 WGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
WGV ++G +C C CH CR V ++C
Sbjct: 528 WGVTKQGYRCRECGLCCHKHCRDQVKVEC 556
>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
Length = 604
Score = 52.8 bits (125), Expect = 4e-07
Identities = 27/89 (30%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 13 LAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPATHTWCDLCGDFI 72
L P R G+G E + C+ +L H F T+CD C F+
Sbjct: 436 LHPPPRQGRGSFSREELTGYLLRASAICS---KLGLAFLHTFHEVTFRKPTFCDSCSGFL 492
Query: 73 WGVVRKGLQCAHCKFTCHYRCRALVCLDC 101
WGV ++G +C C CH CR V ++C
Sbjct: 493 WGVTKQGYRCRECGLCCHKHCRDQVKVEC 521
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,666,772
Number of Sequences: 37866
Number of extensions: 712238
Number of successful extensions: 2322
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 2180
Number of HSP's gapped (non-prelim): 144
length of query: 340
length of database: 18,247,518
effective HSP length: 103
effective length of query: 237
effective length of database: 14,347,320
effective search space: 3400314840
effective search space used: 3400314840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.