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Search of human proteins with 20127422
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20127422 Down syndrome cell adhesion molecule isoform
CHD2-42 precursor [Homo sapiens]
(2012 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 4036 0.0
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 2453 0.0
gi|222352127 sidekick 2 [Homo sapiens] 330 7e-90
gi|119220552 sidekick 1 [Homo sapiens] 314 6e-85
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 270 1e-71
gi|110349719 titin isoform N2-A [Homo sapiens] 252 3e-66
gi|157311649 neogenin homolog 1 [Homo sapiens] 247 1e-64
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 243 1e-63
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 243 1e-63
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 243 2e-63
gi|75709184 contactin 3 [Homo sapiens] 242 2e-63
gi|118572606 hemicentin 1 [Homo sapiens] 240 1e-62
gi|7657359 contactin 5 isoform long [Homo sapiens] 239 3e-62
gi|28373129 contactin 5 isoform short [Homo sapiens] 239 3e-62
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 232 2e-60
gi|4827022 contactin 2 precursor [Homo sapiens] 231 4e-60
gi|19743806 roundabout 1 isoform b [Homo sapiens] 229 2e-59
gi|4506569 roundabout 1 isoform a [Homo sapiens] 229 2e-59
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 229 3e-59
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 228 3e-59
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 228 3e-59
gi|224994173 roundabout 1 isoform d [Homo sapiens] 226 1e-58
gi|224994171 roundabout 1 isoform c [Homo sapiens] 226 1e-58
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 226 1e-58
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 226 1e-58
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 226 1e-58
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens] 225 3e-58
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens] 225 3e-58
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 221 4e-57
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 219 2e-56
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 4036 bits (10466), Expect = 0.0
Identities = 2012/2012 (100%), Positives = 2012/2012 (100%)
Query: 1 MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYL 60
MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYL
Sbjct: 1 MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYL 60
Query: 61 ATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKA 120
ATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKA
Sbjct: 61 ATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKA 120
Query: 121 VLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGA 180
VLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGA
Sbjct: 121 VLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGA 180
Query: 181 LYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQ 240
LYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQ
Sbjct: 181 LYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQ 240
Query: 241 RVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYG 300
RVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYG
Sbjct: 241 RVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYG 300
Query: 301 TAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNV 360
TAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNV
Sbjct: 301 TAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNV 360
Query: 361 RITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSP 420
RITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSP
Sbjct: 361 RITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSP 420
Query: 421 AEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGG 480
AEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGG
Sbjct: 421 AEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGG 480
Query: 481 VYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKN 540
VYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKN
Sbjct: 481 VYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKN 540
Query: 541 SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQ 600
SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQ
Sbjct: 541 SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQ 600
Query: 601 PFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLS 660
PFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLS
Sbjct: 601 PFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLS 660
Query: 661 LMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPT 720
LMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPT
Sbjct: 661 LMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPT 720
Query: 721 IVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSM 780
IVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSM
Sbjct: 721 IVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSM 780
Query: 781 YLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTK 840
YLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTK
Sbjct: 781 YLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTK 840
Query: 841 EVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKART 900
EVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKART
Sbjct: 841 EVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKART 900
Query: 901 ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRM 960
ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRM
Sbjct: 901 ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRM 960
Query: 961 YAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGY 1020
YAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGY
Sbjct: 961 YAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGY 1020
Query: 1021 QIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEII 1080
QIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEII
Sbjct: 1021 QIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEII 1080
Query: 1081 TTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEI 1140
TTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEI
Sbjct: 1081 TTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEI 1140
Query: 1141 KNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAA 1200
KNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAA
Sbjct: 1141 KNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAA 1200
Query: 1201 SASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVW 1260
SASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVW
Sbjct: 1201 SASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVW 1260
Query: 1261 VVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM 1320
VVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM
Sbjct: 1261 VVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM 1320
Query: 1321 KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP
Sbjct: 1321 KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
Query: 1381 DQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLEN 1440
DQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLEN
Sbjct: 1381 DQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLEN 1440
Query: 1441 LKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN 1500
LKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN
Sbjct: 1441 LKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN 1500
Query: 1501 DGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQ 1560
DGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQ
Sbjct: 1501 DGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQ 1560
Query: 1561 ANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRR 1620
ANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRR
Sbjct: 1561 ANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLVVRRRR 1620
Query: 1621 REQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDD 1680
REQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDD
Sbjct: 1621 REQRLKRLRDAKSLAEMLMSKNTRTSDTLSKQQQTLRMHIDIPRAQLLIEERDTMETIDD 1680
Query: 1681 RSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGP 1740
RSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGP
Sbjct: 1681 RSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTRRNAKAGP 1740
Query: 1741 TARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSS 1800
TARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSS
Sbjct: 1741 TARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQDTDRARSS 1800
Query: 1801 MVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTS 1860
MVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTS
Sbjct: 1801 MVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNEYTDSLTS 1860
Query: 1861 STPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSR 1920
STPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSR
Sbjct: 1861 STPSESGICRFTASPPKPQDGGRVMNMAVPKAHRPGDLIHLPPYLRMDFLLNRGGPGTSR 1920
Query: 1921 DLSLGQACLEPQKSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELG 1980
DLSLGQACLEPQKSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELG
Sbjct: 1921 DLSLGQACLEPQKSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELG 1980
Query: 1981 QAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV 2012
QAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV
Sbjct: 1981 QAAKMSSSQESLLDSRGHLKGNNPYAKSYTLV 2012
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 2453 bits (6357), Expect = 0.0
Identities = 1227/2073 (59%), Positives = 1540/2073 (74%), Gaps = 81/2073 (3%)
Query: 1 MWILA-LSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWY 59
MW++ L L S ED+ +SLYFVN SLQ+V F+S+ G +VPCPAAG P LRWY
Sbjct: 61 MWLVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALRWY 120
Query: 60 LATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIK 119
LATG++IYDVP IRHVH NGTLQ++PF PS+F++ IHDN Y+CTAEN +GKIRS ++ +K
Sbjct: 121 LATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAENAAGKIRSPNIRVK 180
Query: 120 AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTG 179
AV REPYTVRVEDQ++MRGNVAVFKC+IPSSV+ Y++VVSWEKDTVS++ RF IT G
Sbjct: 181 AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFFITYHG 240
Query: 180 ALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAG 239
LYI DVQ ED L YRCIT+H+Y+GETRQSN ARL V+DPA S P+ILDGF ++ AG
Sbjct: 241 GLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQEVWAG 300
Query: 240 QRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRY 299
VELPC A G+P P RWLKD PL R+ K +TGL I ++R DSG+Y+CEV+N +
Sbjct: 301 HTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTNTF 360
Query: 300 GTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN 359
G+A+ G L V PL T++P+K+K+ +GS V LSC++TG+ + + WYRN E++ P +
Sbjct: 361 GSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEA 420
Query: 360 VRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVS 419
+ I G+++E L++ KS GAYQCF + +AQD+ + LEDGTP+I+S+FSEKVV+
Sbjct: 421 ISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKVVN 480
Query: 420 PAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
P E SLMC KG P PT+TW LDD+PI++ GSHR +Q S+G +S++N++ Q+RDG
Sbjct: 481 PGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
Query: 480 GVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK 539
GVYRCTA N G YQARINVRGP SIR M+NITA+AGRDT I+CRVIGYPYYSIKWYK
Sbjct: 541 GVYRCTARNLVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK 600
Query: 540 NSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFI 599
++ LLP NHRQV FE NGTLKL+DVQK +DEGEY C+VL+QPQLS SQSVHV VKVPP I
Sbjct: 601 DALLLPDNHRQVVFE-NGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLI 659
Query: 600 QPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNL 659
QPFEFP SIGQ ++IPCVV SGD+PI ITW+KDG+ I GVTI++ +F SSL+IS++
Sbjct: 660 QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSV 719
Query: 660 SLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVP 719
SL HNGNYTCIA N AA V + QLIVRVPP+FVVQP +QDGIYGKA +LNCS +GYP P
Sbjct: 720 SLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPP 779
Query: 720 TIVWKFSKGAGVP-QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSK 778
++WK +KG+G P Q+ P+ L GRIQ+L N SLLI+HV+EED GYYLC+ SN VG D+SK
Sbjct: 780 KVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISK 839
Query: 779 SMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPE-MARYLV 837
SM+LTVKIPAMITS+PNTT+A +G KE++CTA GE+PII+RWEK D +I+P+ + RY +
Sbjct: 840 SMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAI 899
Query: 838 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVK 897
+TK+ G+EV+STL++ P R DS FFSCHAINSYGEDRG+IQLTVQEPPDPPE+EI++VK
Sbjct: 900 ATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVK 959
Query: 898 ARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYS 957
AR++ LRWT FDGNS ITG+DIE KNKSDSWD Q T+++SP +N A I+D+HP+S YS
Sbjct: 960 ARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYS 1019
Query: 958 IRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGII 1017
IRMY+ N+IG+SEPS ELTI+ +EAAPDGPP +V L+P++SQSI+VTWKAPKK LQNG+I
Sbjct: 1020 IRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVI 1079
Query: 1018 RGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ 1077
RGYQIGYRE S G N Q++I+ + +GDSEVYTLDNL KF QYG+VVQA NRAGTGPSS
Sbjct: 1080 RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSS 1139
Query: 1078 EIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGEL 1137
EI TTLEDVPS PPENV+A++ + + ISWS + LNG+L+G+RVI+W+ +DGE
Sbjct: 1140 EINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEW 1199
Query: 1138 GEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKA 1197
GE++NITTT+ +EL G+EK+TNYS+QVLA+T+AGDGVRS ++ +TKEDVPGPPAG+KA
Sbjct: 1200 GEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKA 1259
Query: 1198 AAASASMVFVSWLPPLKLNGIIRKYTVFCSHP--YPTVISEFEASPDSFSYRIPNLSRNR 1255
+SAS V VSWLPP K NG+IRKYT+FCS P SE+E SP+ YRI +L+R +
Sbjct: 1260 VPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQ 1319
Query: 1256 QYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSP 1315
QY +WV AVTSAGRGNSSE +T+EP KAPA+I++F GTVTTPWMKD+ LPC +VGDP+P
Sbjct: 1320 QYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAP 1379
Query: 1316 AVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQ 1375
AVKW KDS + V++DG R I +NG+ ++R VKAEDSGYY+C A N G D II+NL
Sbjct: 1380 AVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLL 1439
Query: 1376 VQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERS 1435
VQVPPDQPRLTVSKT++SSITL+W+PGDNGGSSIRG++LQYS DNSE+W IS SERS
Sbjct: 1440 VQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499
Query: 1436 YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLN 1495
++L++LKCGTWYK L A+N VG GRISEIIEAKT G+EP FSK+Q LF IN+T RLN
Sbjct: 1500 FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHINSTHARLN 1559
Query: 1496 LIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAG 1555
L GWN+GGCPIT+ LEYRP GT W R + S L +L+EATWYEL+MR CNSAG
Sbjct: 1560 LQGWNNGGCPITAIVLEYRPKGTWAW-QGLRANSSGEVFLTELREATWYELRMRACNSAG 1618
Query: 1556 CAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTISCILVGVLLLFVLLLV 1615
C + A FATL+YDGSTIPP IKS Q E + +K L TI C ++ L LL +
Sbjct: 1619 CGNETAQFATLDYDGSTIPP-IKS-AQGE-----GDDVKKLFTIGCPVILATLGVALLFI 1671
Query: 1616 VRRRRREQRLKRLRDAKSLAEMLMSKNTRTSDTLSK-QQQTLRMHIDIPRAQLLIEERDT 1674
VR++R+E+RLKRLRDAKSLAEML+SKN R+ DT K Q R+HIDIPR QLLIE+++
Sbjct: 1672 VRKKRKEKRLKRLRDAKSLAEMLISKNNRSFDTPVKGPPQGPRLHIDIPRVQLLIEDKEG 1731
Query: 1675 METI-DDRSTVLLTDADFGEAAKQKSLTVTHTVHYQSVSQATGPLVDVSDARPGTNPTTR 1733
++ + DD++T+ +TDA+F +A +S ++H+ ++ Q+TGPL+D+SD RPGTNP +R
Sbjct: 1732 IKQLGDDKATIPVTDAEFSQAVNPQSFCTGVSLHHPTLIQSTGPLIDMSDIRPGTNPVSR 1791
Query: 1734 RNAKAGPTARNRYASQWTLNRPHPTISAHTLTTDWRLPTPRAAGSVDKESDSYSVSPSQD 1793
+N K+ + RNRY+SQWTL + + A TLT+DWR + +V ESDSYS S SQD
Sbjct: 1792 KNVKSAHSTRNRYSSQWTLTKCQASTPARTLTSDWRTVGSQHGVTV-TESDSYSASLSQD 1850
Query: 1794 TDRARSSMVSTESASSTYEELARAYEHAKMEEQLRHAKFTITECFISDTSSEQLTAGTNE 1853
TD+ R+SMVSTESASSTYEELARAYEHAK+EEQL+HAKF ITECFISD+SS+Q+T GTNE
Sbjct: 1851 TDKGRNSMVSTESASSTYEELARAYEHAKLEEQLQHAKFEITECFISDSSSDQMTTGTNE 1910
Query: 1854 YTDSLTS-STPSESGICRFTASPPKPQDGGRVMNMAVPKAHR--PGDLIHLPPYLRMDFL 1910
DS+TS STPSE GICRFTASPPKPQD R N+AVP HR D +LP Y + +
Sbjct: 1911 NADSMTSMSTPSEPGICRFTASPPKPQDADRGKNVAVPIPHRANKSDYCNLPLYAKSEAF 1970
Query: 1911 LNR---------------------------------------------GGPGTSRDLSLG 1925
+ G P + +L
Sbjct: 1971 FRKADGREPCPVVPPREASIRNLARTYHTQARHLTLDPASKSLGLPHPGAPAAASTATLP 2030
Query: 1926 QACLEPQKSRTLKRPTVLEPIPMEAASSASSTREGQSWQPGAVATLPQREGAELGQAAKM 1985
Q L P P P E ++ S+ P A +T P R G G KM
Sbjct: 2031 QRTLAMPAPPAGTAPPAPGPTPAEPPTAPSAA-------PPAPSTEPPRAG---GPHTKM 2080
Query: 1986 SSSQESLLD------SRGHLKGNNPYAKSYTLV 2012
S++SLL+ R +G Y+KSYTLV
Sbjct: 2081 GGSRDSLLEMSTSGVGRSQKQGAGAYSKSYTLV 2113
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 330 bits (847), Expect = 7e-90
Identities = 352/1291 (27%), Positives = 541/1291 (41%), Gaps = 135/1291 (10%)
Query: 328 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHE-NLIMDHMVKSDGGAYQCF 386
G+++ L+C G+ E W N N +T + E ++ + ++ G Y+C
Sbjct: 41 GNRLVLTCMAEGSWPLEFKWLHN--------NRELTKFSLEYRYMITSLDRTHAGFYRCI 92
Query: 387 VRKDK---LSAQDYVQVV----LEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTIT 439
VR L Q VQV E+G + E V A ++ P P +T
Sbjct: 93 VRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASF------PQPQVT 146
Query: 440 WTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTA------NNSAGVV 493
W D I S RI+ IT E +V I S+ D G Y A +N
Sbjct: 147 WFRDGRKIPP--SSRIA--ITLENTLV----ILSTVAPDAGRYYVQAVNDKNGDNKTSQP 198
Query: 494 LYQARINVRGPAS------IRPMKNITAIAGR-DTYIHCRVIGYPYYSIK--WYKNSNLL 544
+ NV GPA I P KN + +AG + + C P + W K+ LL
Sbjct: 199 ITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLL 258
Query: 545 PFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQL--STSQSVHVTVKVPP-FI-Q 600
++N L + + D G Y C +++ S + +++V PP F+ +
Sbjct: 259 SGG----ISDHNRRLTIPNPTGS-DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKE 313
Query: 601 PFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLS 660
P + + V IPC G P +ITW KD + +T L+IS L
Sbjct: 314 PERHITAEMEKVVDIPCQA-KGVPPPSITWYKDAAVVEVEK-LTRFRQRNDGGLQISGLV 371
Query: 661 LMHNGNYTCIARNEAAAVEHQSQLIVR-VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVP 719
G + C ARN A V+ + L V + P P D I G +V+L C G P P
Sbjct: 372 PDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRP 431
Query: 720 TIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKS 779
I W+ KG + + L R L +GSLLI D+G Y C +N G D + S
Sbjct: 432 AITWQ--KGERILASGSVQLP-RFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEA-S 487
Query: 780 MYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR--WEKEDRIINPEMARYLV 837
L V IT P +G + M C + + +R WEK+ + E
Sbjct: 488 ADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTE------ 541
Query: 838 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPE---IEIK 894
S + + +L I T D G ++C I++ G D L V++ P PE +
Sbjct: 542 SHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLS 601
Query: 895 DVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSS 954
V+ R I L WT FDGNSP+ Y +E + W + D P+ S T+ + P+
Sbjct: 602 TVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVD--PKATSVTVKGLVPAR 659
Query: 955 TYSIRMYAKNRIGKSEPSNELT-ITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQ 1013
+Y R+ A N +GK + S + ++ E P PPQ V ++QSI + W+ P + Q
Sbjct: 660 SYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQ 719
Query: 1014 NGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG 1073
NGI++GY I Y +QF I T D L++L +T Y + V A N AG G
Sbjct: 720 NGILKGYIIRYCLAGLPVGYQFKNI---TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLG 776
Query: 1074 PSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLM 1133
S ++ TL+ VP+ PP NV A AT+ +I +W+ S + +NGI QG+++I W
Sbjct: 777 VYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQ 836
Query: 1134 DGELGEIKNITTTQPSLE---LDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG 1190
+ E+ + Q S+ + GL+K+T Y VL FT GDG RS RT EDVPG
Sbjct: 837 EEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPG 896
Query: 1191 PPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPD-SFSYRIP 1249
P + + + + VSW P + NGI+ Y + T P+ + YR+
Sbjct: 897 PVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVT 956
Query: 1250 NLSRNRQYSVWVVAVTSAGRGN-SSEIIT--VEPLAKAPARILTFSG------------- 1293
L+ Y++ V A+TS G+G S+ I+ V P P L S
Sbjct: 957 GLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPG 1016
Query: 1294 ----TVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTV 1349
T + W+ + + G+ + + + S+ D + F+ SF +R V
Sbjct: 1017 YDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPD--LNPFTCYSFRMRQV 1074
Query: 1350 KAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSS--SITLSWLP----GD 1403
I + S +Q PPD VS T+S S+ L W+P
Sbjct: 1075 N---------IVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEY 1125
Query: 1404 NGGSSIRGYILQY--SEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGR 1461
NG GY ++Y S+ + + ER Y +E+L+ T Y+ + A N +G G
Sbjct: 1126 NGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGP 1185
Query: 1462 ISEIIEAKTLGKEPQF--SKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTT 1519
S+ + +T P + L + ++ VR + + D + + + Y+ +
Sbjct: 1186 WSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSD 1245
Query: 1520 V----W-------TTAQRTSLSKSYILYDLQ 1539
W +AQ T L K Y+LY++Q
Sbjct: 1246 TQPRFWLVEGNSSRSAQLTGLGK-YVLYEVQ 1275
Score = 195 bits (496), Expect = 3e-49
Identities = 184/697 (26%), Positives = 299/697 (42%), Gaps = 73/697 (10%)
Query: 819 VRWEKEDRIINPEMARYLVST----KEVGEEVIST--LQILPTVREDSGFFSCHAINSYG 872
+ WE+ +R N + YL + + G ++T +++ + G S I+S
Sbjct: 930 ISWEEYNRT-NTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISS-- 986
Query: 873 EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECK----NKSDS 928
+ + P P + I ++ R++TL++ G+DG + I+ + +E + + +
Sbjct: 987 ------GVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEE 1040
Query: 929 WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN-ELTITADEAAPDGP 987
W + + P S + D++P + YS RM N +G S PS I +A PD
Sbjct: 1041 WLLIHQLSN-EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMA 1099
Query: 988 PQEVHLEPISSQSIRVTWKAPKKHLQNGIIR--GYQIGYREYSTGGNFQFNIISVDTSGD 1045
P V L S S+ + W + NG GY+I Y G +++ D
Sbjct: 1100 PANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERD 1159
Query: 1046 SEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESI 1105
YT+++L ++T+Y + VQA N G+GP SQ ++ T E VPS P NV A+AT+ S+
Sbjct: 1160 ---YTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSM 1216
Query: 1106 SISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQV 1165
+ WS + + NG++ G++V+Y D + + S +L GL KY Y +QV
Sbjct: 1217 LVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQV 1276
Query: 1166 LAFTRAGDGVRSE-QIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTV 1224
LAFTR GDG S I RT +DVPGPP G+ + V + W PP NGII Y +
Sbjct: 1277 LAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQI 1336
Query: 1225 FCSHPYPTVISEFEA----SPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITV-- 1278
+H T + +P + Y L Y + A T G G ++E + V
Sbjct: 1337 --THRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTT 1394
Query: 1279 --EPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDP-SPAVKWMKDSNGTPSLVTIDGR 1335
+ P+R + V + ++L + D SP + + PS
Sbjct: 1395 EKRDRPQPPSRPMVQQEDVRA---RSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHS 1451
Query: 1336 RSIFSN-GSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQ----VQVPPDQPR--LTVS 1388
S+ N SFI+ +K S + A N+ G E + +Q PD+ L+V+
Sbjct: 1452 ASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVT 1511
Query: 1389 KTTSSSITLSWLP--GDNGGSSIRGYILQYSEDNSEQWGSFPI----------------- 1429
T++S+ + W P D + G+ ++Y E E F +
Sbjct: 1512 PHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMY 1571
Query: 1430 ------SPSERSYRLENLKCGTWYKFTLTAQNGVGPG 1460
PS Y L+NL Y+ ++ N VG G
Sbjct: 1572 SMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG 1608
Score = 176 bits (445), Expect = 3e-43
Identities = 110/359 (30%), Positives = 174/359 (48%), Gaps = 22/359 (6%)
Query: 884 EPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKN-KSDSWDSAQRTKDVSPQL 942
+PP P ++ +DV+AR++ L W G DG SP+ Y I+ + S W A + VS
Sbjct: 1401 QPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRW--ALHSASVSHNA 1458
Query: 943 NSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEL-TITADEAAPDGPPQEVHLEPISSQSI 1001
+S + + P ++Y R+ A N IG SE S E ++T +AAPD P + + P ++ S+
Sbjct: 1459 SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSV 1518
Query: 1002 RVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEV------------- 1048
+ W+ P + NGI+ G++I YRE G F + ++ G +
Sbjct: 1519 LIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSR 1578
Query: 1049 -----YTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPE 1103
Y LDNLNK +Y + + N G GPSS E VP+ P NV +
Sbjct: 1579 PSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATAT 1638
Query: 1104 SISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSI 1163
+ ++W ++ NG +QG+++ +W +K + + S++L L YT Y +
Sbjct: 1639 QLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMV 1698
Query: 1164 QVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKY 1222
V AF AGDG RS +T++ P P+ VK + + + V VSW P NGI+ Y
Sbjct: 1699 SVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGY 1757
Score = 160 bits (405), Expect = 1e-38
Identities = 318/1528 (20%), Positives = 561/1528 (36%), Gaps = 161/1528 (10%)
Query: 125 PY--TVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALY 182
PY T V Q + GN V C+ S + ++ R++ITS +
Sbjct: 26 PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLDRTH 85
Query: 183 IKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRV 242
YRCI R+R ++ ++ S +G H+ G+
Sbjct: 86 AGF---------YRCIVRNRMGALLQRQTEVQVAYMG------SFEEGEKHQSVSHGEAA 130
Query: 243 ELPCKALGH-PEPDYRWLKDNMPLELSGRFQKTV--TGLLIENIRPSDSGSYVCEVSNRY 299
+ + P+P W +D + S R T+ T +++ + P YV V+++
Sbjct: 131 VIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKN 190
Query: 300 GTAKVIGRLYVK--------QPLKATIS-PRKVKSSVG--SQVSLSCSVTGTEDQELS-- 346
G K + + P+ TI P K S V S+V+L C +L
Sbjct: 191 GDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHII 250
Query: 347 WYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQC-----------FVRKDKLSAQ 395
W ++G +L+ G ++ L + + SD G Y+C VR LS
Sbjct: 251 WKKDGVLLSGG-----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 305
Query: 396 DYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRI 455
+ Q V E + I+A EKVV + C KG P P+ITW D + R
Sbjct: 306 EPPQFVKEP--ERHITAEMEKVVD------IPCQAKGVPPPSITWYKDAAVVEVEKLTRF 357
Query: 456 SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG--PASIRPMKNI 513
Q ++G L IS D G+++C A N+AG V + V P R +
Sbjct: 358 RQR--NDGG----LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS 411
Query: 514 TAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFEN---NGTLKLSDVQKEVDE 570
T I G + C G P +I W K +L Q+ +G+L +S D
Sbjct: 412 TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHIS-DA 470
Query: 571 GEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGD-LPITIT 629
G YTC + + + V +P + G + + C V + I
Sbjct: 471 GTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYI 530
Query: 630 WQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVP 689
W+KDG + G+ +D SL IS G YTC + + L VR
Sbjct: 531 WEKDGATL-GTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQL 589
Query: 690 PKFVVQP-RDQDGIYGKAVILNCSAE---GYPVPTIVWKFSKGAGVPQFQPIALNGRIQV 745
P P + +A+ L + P+ + + S+ +++ +
Sbjct: 590 PHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKAT- 648
Query: 746 LSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKK 805
S+ +K +V S + NDVG V +P + P + G+
Sbjct: 649 ----SVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTN 704
Query: 806 EMSCTAHGEKPIIVRWEK-----EDRIINPEMARYLVSTKEVGEEV--ISTLQILPTVRE 858
+ I+++W+ ++ I+ + RY ++ VG + I+ + + E
Sbjct: 705 QS---------IMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLE 755
Query: 859 DSGFFSCHAI-----NSYG---EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFD 910
D ++ + I NS G + + T+Q P P + + T+R+T
Sbjct: 756 DLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAP 815
Query: 911 GNSPITGYDIECKNKSDSWDSAQRTK--------DVSPQLNSATIIDIHPSSTYSIRMYA 962
I G I K +W+ Q + + ++ + + + Y +
Sbjct: 816 SPQFING--INQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLC 873
Query: 963 KNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQI 1022
G S + E P GP + I S++V+W+ P + +NGI+ GY+I
Sbjct: 874 FTTPGDGPRSTPQLVRTHEDVP-GPVGHLSFSEILDTSLKVSWQEPGE--KNGILTGYRI 930
Query: 1023 GYREYS-TGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIIT 1081
+ EY+ T + +V Y + L T Y + V A G G S I+
Sbjct: 931 SWEEYNRTNTRVTHYLPNVTLE-----YRVTGLTALTTYTIEVAAMTSKGQGQVSASTIS 985
Query: 1082 TTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIK 1141
+ + PP N+ P S+++ + + I + + +GE +
Sbjct: 986 SGVPPELPGPPTNLGISNIGPRSVTLQFRP-GYDGKTSISRWLVEAQVGVVGEGEEWLLI 1044
Query: 1142 NITTTQP---SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPP----AG 1194
+ + +P S+E+ L +T YS ++ G S+ +R + + PP A
Sbjct: 1045 HQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQP--SRKIQTLQAPPDMAPAN 1102
Query: 1195 VKAAAASASMVFVSW--LPPLKLNG----IIRKYTVFCSHPYPTVISEFEASPDSFSYRI 1248
V AS + +++ W LP ++ NG + K S + +S Y I
Sbjct: 1103 VSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTI 1162
Query: 1249 PNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPAR-------ILTFSGTVTTPWMK 1301
+L +Y V V A + G G S+ + P+ + T S ++ W +
Sbjct: 1163 EDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSE 1222
Query: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS----IFSNGSFIIRTVKAEDSGYY 1357
+ + KDS+ P ++G S + G +++ V+ +
Sbjct: 1223 VPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLA---F 1279
Query: 1358 SCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYS 1417
+ I + + I+ VP + + ++S+ L W P I Y + +
Sbjct: 1280 TRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHR 1339
Query: 1418 EDNSEQWGSFP--ISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEP 1475
+ + + ++PS R Y LK + Y F +TAQ G G +E + T K
Sbjct: 1340 LNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL-VVTTEKRD 1398
Query: 1476 QFSKEQELFASINTTRVRLNLIGW---NDGGCPITSFTLEYR--PFGTTVWTTAQRTSLS 1530
+ R R L+ W +DG P+ +T++ R P G +A + +
Sbjct: 1399 RPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNA 1458
Query: 1531 KSYILYDLQEATWYELQMRVCNSAGCAE 1558
S+I+ L+ T Y+ +++ N G +E
Sbjct: 1459 SSFIVDRLKPFTSYKFRVKATNDIGDSE 1486
Score = 137 bits (344), Expect = 1e-31
Identities = 163/659 (24%), Positives = 270/659 (40%), Gaps = 76/659 (11%)
Query: 877 IIQLTVQEPPDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRT 935
I++ T+ + P PP I +V+ ++ L W N I Y I + + + ++A
Sbjct: 1292 ILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTAT-V 1350
Query: 936 KDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQE--VHL 993
+ ++P T + P S Y R+ A+ R G E + L +T ++ PP V
Sbjct: 1351 EVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQ 1410
Query: 994 EPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDN 1053
E + ++S+ ++W+ L +R Y I RE +G ++ + S S ++ + +D
Sbjct: 1411 EDVRARSVLLSWEPGSDGLSP--VRYYTIQTRELPSG---RWALHSASVSHNASSFIVDR 1465
Query: 1054 LNKFTQYGLVVQACNRAGTGPSSQEIIT-TTLEDVPSYPPENVQAIATSPESISISWSTL 1112
L FT Y V+A N G S+E + TTL+ P P + + S+ I W
Sbjct: 1466 LKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPP 1525
Query: 1113 SKEALNGILQGFRVIYWANLMDGELG--------------------EIKNITTTQPSL-- 1150
+++ +NGIL GFR+ Y L +G G ++N++ +PSL
Sbjct: 1526 AEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLS--RPSLTQ 1583
Query: 1151 -ELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP-GPPAGVKAAAASASMVFVS 1208
ELD L K+ Y I++ + G+G S E VP P V A+A+ + V+
Sbjct: 1584 YELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVT 1643
Query: 1209 WLPPL--KLNGIIRKYTVFCSHPYPTVISE-----FEASPDSFSYRIPNLSRNRQYSVWV 1261
W PP NG I+ Y ++ ++E F A S ++ NL+ Y V V
Sbjct: 1644 WEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAEN---SVKLKNLTGYTAYMVSV 1700
Query: 1262 VAVTSAGRGNSSEIITVEPLAKAPAR--ILTFSGTVTTP---------WMKDIVLPCKAV 1310
A +AG G S + AP+ + FS TT + I+ + V
Sbjct: 1701 AAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLV 1760
Query: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVK-AEDSGY-YSCIANNNWGSD 1368
+P V +G +VT+D + N ++ AE Y + A
Sbjct: 1761 YEPCSPV------DGVSKIVTVD----VKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGP 1810
Query: 1369 EIILNLQV---QVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWG 1425
EI N+ + P P + + SS+I + W GD G I Y+++ + W
Sbjct: 1811 EIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWD 1870
Query: 1426 ----SFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKE 1480
P S ++ ++ LK G Y F + A N G G S ++ K F +E
Sbjct: 1871 ILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANPFYEE 1929
Score = 134 bits (337), Expect = 9e-31
Identities = 155/614 (25%), Positives = 238/614 (38%), Gaps = 46/614 (7%)
Query: 1 MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYL 60
+W L L+L Q A +D+ S YF ++ V ++ C A G P+ +W
Sbjct: 6 IWTL-LALHQIRAARAQDDV--SPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKW-- 60
Query: 61 ATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLI---HDNTYYCTAENPSGKIRSQDVH 117
+H N L F T + H Y C N G + +
Sbjct: 61 --------------LHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTE 106
Query: 118 IKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITS 177
++ + + Q G AV + P V+W +D + SR IT
Sbjct: 107 VQVAYMGSFEEGEKHQSVSHGEAAVIRA--PRIASFPQPQVTWFRDGRKIPPSSRIAITL 164
Query: 178 TGALYI-KDVQNEDGLYNYRCITRHRYTGETRQSNSARLF-VSDPANS-APSILDGFDHR 234
L I V + G Y + + +T Q + + V PA+ AP+I+ +
Sbjct: 165 ENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNT 224
Query: 235 KAMAG-QRVELPCKALGHP--EPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSY 291
+AG V L C A P + W KD + L SG L I N SD+G Y
Sbjct: 225 SVVAGTSEVTLECVANARPLIKLHIIWKKDGVLL--SGGISDHNRRLTIPNPTGSDAGYY 282
Query: 292 VCEVSNRYGTAKVIGR---LYVKQPLKATISP-RKVKSSVGSQVSLSCSVTGTEDQELSW 347
CE R + + R L V +P + P R + + + V + C G ++W
Sbjct: 283 ECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW 342
Query: 348 YRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTP 407
Y++ ++ K R N L + +V D G +QCF R Q + + P
Sbjct: 343 YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAP 402
Query: 408 KIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVS 467
I + V V L C G P P ITW + IL GS ++ + E
Sbjct: 403 NITRGPLDSTVIDGMSVVLACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLES---G 458
Query: 468 YLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI-RPMKNITAIAGRDTYIHCR 526
L IS + + D G Y C A NS GV A + V I +P ++ + I G + C
Sbjct: 459 SLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCG 518
Query: 527 VIGYPYYSIK--WYKN-SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQL 583
V P +I+ W K+ + L +H ++ + NG+L +S D G YTC V +
Sbjct: 519 VTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSG-DIGTYTCRV-ISAGG 576
Query: 584 STSQSVHVTVKVPP 597
+ S+S H+ V+ P
Sbjct: 577 NDSRSAHLRVRQLP 590
Score = 76.3 bits (186), Expect = 3e-13
Identities = 75/283 (26%), Positives = 124/283 (43%), Gaps = 18/283 (6%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C DP ++++ + +G R + NGS I + D G Y+C + G
Sbjct: 517 CGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGG 576
Query: 1367 SDEIILNLQV-QVP--PDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQ 1423
+D +L+V Q+P P+ P T+S +I L+W +G S + YIL+ SE+N+
Sbjct: 577 NDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAP- 635
Query: 1424 WGSF--PISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQ 1481
W + P S ++ L Y+F L A N VG G+ S+ E +L +EP + Q
Sbjct: 636 WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQ 695
Query: 1482 ELFASINTTRVRLNLIGW------NDGGCPITSFTLEYRPFGTTVWTTAQRTSLS--KSY 1533
+ AS T + +I W + G + + + Y G V + + + +
Sbjct: 696 NVIASGRTN--QSIMIQWQPPPESHQNGI-LKGYIIRYCLAGLPVGYQFKNITDADVNNL 752
Query: 1534 ILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDG-STIPP 1575
+L DL T YE+++ NSAG + G T+PP
Sbjct: 753 LLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPP 795
Score = 42.4 bits (98), Expect = 0.005
Identities = 54/221 (24%), Positives = 91/221 (41%), Gaps = 23/221 (10%)
Query: 1378 VPPDQPR-LTVSKTTSSSITLSWLPG--DNGGSSIRGYILQYSEDNSEQWGSFP-----I 1429
VP PR + V T++ + ++W P D+ I+GY + + E Q G+ +
Sbjct: 1622 VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWE---AQRGNLTERVKTL 1678
Query: 1430 SPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINT 1489
+E S +L+NL T Y ++ A N G G S + +T P + F+ + T
Sbjct: 1679 FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPS-APSSVKFSELTT 1737
Query: 1490 TRVRLNLIGWNDGGCP---ITSFTLEYRPF----GTTVWTTAQRTSLSKSYI-LYDLQEA 1541
T V + W P + + L Y P G + T S ++ + DL E
Sbjct: 1738 TSVN---VSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEG 1794
Query: 1542 TWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQ 1582
Y ++R E +AN T +G+ PP + +V+
Sbjct: 1795 VTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVR 1835
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 314 bits (804), Expect = 6e-85
Identities = 328/1247 (26%), Positives = 516/1247 (41%), Gaps = 150/1247 (12%)
Query: 328 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFV 387
G+++ L+C G+ E W R+ L T + I+ + K D G Y+C V
Sbjct: 119 GNRLVLTCLAEGSWPLEFKWMRDDSELT-------TYSSEYKYIIPSLQKLDAGFYRCVV 171
Query: 388 RKDK---LSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSL-MCNVKGTPLPTITWTLD 443
R L + VQV + K VS L + + P P +TW +
Sbjct: 172 RNRMGALLQRKSEVQVAYMGS---FMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFRE 228
Query: 444 DDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANN--------SAGVVLY 495
I+ S+RI+ IT E +V I ++ D G Y A N S + L
Sbjct: 229 GHKIIP--SNRIA--ITLENQLV----ILATTTSDAGAYYVQAVNEKNGENKTSPFIHLS 280
Query: 496 QARI----NVRGPASIRPMKNITAIAGR-DTYIHCRVIGYPY--YSIKWYKN-----SNL 543
AR P + P N + +AG +T + C P S+ W +N S L
Sbjct: 281 IARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGL 340
Query: 544 LPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLV-----QPQLSTSQSVHVTVKVPPF 598
F R L +S+ D G Y C + +P +T+ + + PP+
Sbjct: 341 HSFGRR---------LTISN-PTSADTGPYVCEAALPGSAFEPARATA---FLFIIEPPY 387
Query: 599 IQPFEFPRFS--IGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRI 656
R S + + V I C + LP T+ W KD I L + + LRI
Sbjct: 388 FTAEPESRISAEVEETVDIGCQAMGVPLP-TLQWYKDAISI-SRLQNPRYKVLASGGLRI 445
Query: 657 SNLSLMHNGNYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPRDQDGIYGKAVILNCSAEG 715
L +G + C A NE ++ + L + + P F +P D G IL C G
Sbjct: 446 QKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSG 505
Query: 716 YPVPTIVWK------FSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVS 769
P P I WK S +P+F +L +G L I V +D+G Y C +
Sbjct: 506 APKPAITWKRENHILASGSVRIPRFM---------LLESGGLQIAPVFIQDAGNYTCYAA 556
Query: 770 NDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR--WEKEDRI 827
N G+ ++ S LTV I P + +G + C A + + +R W+K++
Sbjct: 557 NTEGS-LNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVA 615
Query: 828 INPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 887
+ P ST + E +L I T D G +SC ++ G D + +L V E P
Sbjct: 616 LTPS------STSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPH 669
Query: 888 PPE---IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNS 944
P+ + + + L W FDGNSPI Y +E + W +V P++
Sbjct: 670 SPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKV--HLSNVGPEMTG 727
Query: 945 ATIIDIHPSSTYSIRMYAKNRIGKSEPSNELT-ITADEAAPDGPPQEVHLEPISSQSIRV 1003
T+ + P+ TY R+ A N +G+ + S E + + E P PP+ + ++QSI V
Sbjct: 728 VTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMV 787
Query: 1004 TWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLV 1063
W+ P + NG++RGY + YR G +Q I TS + + +L +TQY +
Sbjct: 788 QWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNI---TSPEVNYCLVTDLIIWTQYEIQ 844
Query: 1064 VQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQG 1123
V A N AG G S+ + TL+ VP+ PP+NVQ A + +I W+ ++ +NGI QG
Sbjct: 845 VAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQG 904
Query: 1124 FRVIYWANLMDGELGEIKNITTTQPSL------ELDGLEKYTNYSIQVLAFTRAGDGVRS 1177
++++ W + E + T P + L+K+T Y VL FT GDG S
Sbjct: 905 YKLLAW----PADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPS 960
Query: 1178 EQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEF 1237
T+ED PG + + + VSW PL+ NGII Y + Y S
Sbjct: 961 TPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQI-SWEVYGRNDSRL 1019
Query: 1238 EASPDS--FSYRIPNLSRNRQYSVWVVAVTSAGRG--NSSEIITVEP--LAKAPARILT- 1290
+ +S Y+I LS Y++ V AVT+ G G SS I + P L AP+ ++
Sbjct: 1020 THTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVIS 1079
Query: 1291 --------------FSG-TVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGR 1335
+ G T + W+ + A+GD V ++ N + +
Sbjct: 1080 NISPRSATLQFRPGYDGKTSISRWI--VEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPN 1137
Query: 1336 RSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPD--QPRLTVSKTTSS 1393
+ +++ F ++ V YS S +I L Q PPD +TV + +
Sbjct: 1138 LTPYTHYRFRMKQVNIVGPSPYS-------PSSRVIQTL--QAPPDVAPTSVTVRTASET 1188
Query: 1394 SITLSWLP----GDNGGSSIRGYILQY--SEDNSEQWGSFPISPSERSYRLENLKCGTWY 1447
S+ L W+P NG GY ++Y S+ S ER + +E L+ Y
Sbjct: 1189 SLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEY 1248
Query: 1448 KFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRL 1494
+ + A N VG G SE++ +T P + E ++++T++ L
Sbjct: 1249 ELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILL 1295
Score = 207 bits (526), Expect = 1e-52
Identities = 285/1192 (23%), Positives = 470/1192 (39%), Gaps = 118/1192 (9%)
Query: 426 LMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485
L C +G+ W DD + T+ + Y+ I S Q D G YRC
Sbjct: 124 LTCLAEGSWPLEFKWMRDDSEL------------TTYSSEYKYI-IPSLQKLDAGFYRCV 170
Query: 486 ANNSAGVVLYQ-ARINVRGPASIRPM-KNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSN 542
N G +L + + + V S + T GR ++ I YP + W++ +
Sbjct: 171 VRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGH 230
Query: 543 -LLPFNHRQVAFENN-----------GTLKLSDVQKEVDEGEYT--CNVLVQPQLSTSQS 588
++P N + EN G + V ++ E + + ++ + + T ++
Sbjct: 231 KIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPET 290
Query: 589 VHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLP-ITITWQKDGRPIPGSLGVTIDN 647
+ T+ VPP + + + C+ + + +++TW+++G I L
Sbjct: 291 MAPTIVVPPGNRSV----VAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLH----- 341
Query: 648 IDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQ---LIVRVPPKFVVQPRDQ-DGIY 703
F L ISN + G Y C A +A E L + PP F +P +
Sbjct: 342 -SFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEV 400
Query: 704 GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY 763
+ V + C A G P+PT+ W + + + Q N R +VL++G L I+ + EDSG
Sbjct: 401 EETVDIGCQAMGVPLPTLQW-YKDAISISRLQ----NPRYKVLASGGLRIQKLRPEDSGI 455
Query: 764 YLCKVSNDVGADVSKSMYLTV-KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWE 822
+ C SN+ G ++ YL V I + T P T T G + C G + W+
Sbjct: 456 FQCFASNE-GGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWK 514
Query: 823 KEDRII---NPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQ 879
+E+ I+ + + R+++ LQI P +D+G ++C+A N+ G
Sbjct: 515 RENHILASGSVRIPRFMLLES-------GGLQIAPVFIQDAGNYTCYAANTEGSLNASAT 567
Query: 880 LTVQEPPD---PPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRT- 935
LTV PPE + +K T TL D + Y + N + + S R
Sbjct: 568 LTVWNRTSIVHPPEDHVV-IKGTTATLHCGATHDPRVSLR-YVWKKDNVALTPSSTSRIV 625
Query: 936 --KDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAP-DGPPQEVH 992
KD S ++ DI YS + SE N+ + E PQ +
Sbjct: 626 VEKDGSLLISQTWSGDI---GDYSCEIV-------SEGGNDSRMARLEVIELPHSPQNLL 675
Query: 993 LEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLD 1052
+ P SS S V + N I Y + E ++ + + + +G T+
Sbjct: 676 VSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTG----VTVS 731
Query: 1053 NLNKFTQYGLVVQACNRAGTGPSSQEIITTTL-EDVPSYPPENVQAIATSPESISISWST 1111
L Y V A N G G S E L E+ PS PP+N+ A + +SI + W
Sbjct: 732 GLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQP 791
Query: 1112 LSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLEL-DGLEKYTNYSIQVLAFTR 1170
+ NG+L+G+ + Y + GE + +NIT+ + + L L +T Y IQV A+
Sbjct: 792 PPETEHNGVLRGYILRYRLAGLPGEYQQ-RNITSPEVNYCLVTDLIIWTQYEIQVAAYNG 850
Query: 1171 AGDGVRSEQIFTRTKEDVP-GPPAGVKAAAASASMVFVSWLPPLK--LNGIIRKYTVFC- 1226
AG GV S + T + VP PP V+ A +++ + W PP + +NGI + Y +
Sbjct: 851 AGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAW 910
Query: 1227 SHPYPTVISEFEASPDSFSYR---IPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAK 1283
P ++ +PD I NL + Y V+ T+ G G S V
Sbjct: 911 PADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQED 970
Query: 1284 APARI--LTFSGTVTTPWMKDIVLPCKAVG-----DPSPAVKWMKDSNGTPSLVTIDGRR 1336
P + L+F+ + T P + G S V DS T +L +
Sbjct: 971 KPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEY 1030
Query: 1337 SIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSIT 1396
I S T+ D + + S I + +P L +S + S T
Sbjct: 1031 KIQGLSSLTTYTI---DVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSAT 1087
Query: 1397 LSWLPGDNGGSSIRGYILQYSED---NSEQWGSF---PISPSERSYRLENLKCGTWYKFT 1450
L + PG +G +SI +I++ + E+W + P + + NL T Y+F
Sbjct: 1088 LQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFR 1147
Query: 1451 LTAQNGVGPGRISEIIEA-KTLGKEPQFSKEQELFASINTTRVRLNLIGWND----GGCP 1505
+ N VGP S +TL P + + + T +RL + D G
Sbjct: 1148 MKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPE 1207
Query: 1506 ITSFTLEYRPFGTTVWTTAQRTS--LSKSYILYDLQEATWYELQMRVCNSAG 1555
+ ++Y AQ S L + + + +L+E YELQM+ N+ G
Sbjct: 1208 SVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVG 1259
Score = 204 bits (519), Expect = 7e-52
Identities = 265/1112 (23%), Positives = 442/1112 (39%), Gaps = 95/1112 (8%)
Query: 237 MAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVS 296
+ G R+ L C A G +++W++D+ L K +I +++ D+G Y C V
Sbjct: 117 LEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSEYK----YIIPSLQKLDAGFYRCVVR 172
Query: 297 NRYGTAKVIGRLYVKQPLKATI---SPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEI 353
NR G A + + V+ + RK S + + +T +++W+R G
Sbjct: 173 NRMG-ALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPRPQVTWFREGHK 231
Query: 354 LNPGKNVRITGINHENLIMDHMVKSDGGAY--QCFVRK---DKLSAQDYVQVVLEDGTPK 408
+ P + IT N L++ SD GAY Q K +K S ++ + + GTP+
Sbjct: 232 IIPSNRIAITLEN--QLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPE 289
Query: 409 ------IISAFSEKVVSPAEPVSLMCNVKGTPLP--TITWTLDDDPILKGGSHRISQMIT 460
++ + VV+ + +L C P+ ++TW K RI+ +
Sbjct: 290 TMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTW--------KRNGVRITSGLH 341
Query: 461 SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARIN-----VRGP-ASIRPMKNIT 514
S G L IS+ D G Y C A G AR + P + P I+
Sbjct: 342 SFGR---RLTISNPTSADTGPYVCEA-ALPGSAFEPARATAFLFIIEPPYFTAEPESRIS 397
Query: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNS-NLLPFNHRQVAFENNGTLKLSDVQKEVDEGEY 573
A I C+ +G P +++WYK++ ++ + + +G L++ ++ E D G +
Sbjct: 398 AEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPE-DSGIF 456
Query: 574 TCNVLVQ-PQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQK 632
C + ++ T + VT P F Q + G + C V P ITW++
Sbjct: 457 QCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKP-AITWKR 515
Query: 633 DGRPI-PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPK 691
+ + GS+ + + + L+I+ + + GNYTC A N ++ + L V
Sbjct: 516 ENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTS 575
Query: 692 FVVQPRDQDGIYGKAVILNCSAEGYPVPTI--VWKFSKGAGVPQFQPIALNGRIQVLSNG 749
V P D I G L+C A P ++ VWK A P + RI V +G
Sbjct: 576 IVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTP-----SSTSRIVVEKDG 630
Query: 750 SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSC 809
SLLI D G Y C++ ++ G D + +++P P L + +
Sbjct: 631 SLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELP----HSPQNLLVSPNSSHSHAV 686
Query: 810 TA------HGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFF 863
G PI+ + ++ + + V VG E+ T F
Sbjct: 687 VLSWVRPFDGNSPILYYIVE----LSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFR 742
Query: 864 SCHAINSYGEDRGIIQLT-VQEPPDPPEIEIKDVKA-----RTITLRW--TMGFDGNSPI 915
C A+N G + + + + P +PP K++ A ++I ++W + N +
Sbjct: 743 VC-AVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVL 801
Query: 916 TGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEL 975
GY + + + QR SP++N + D+ + Y I++ A N G S +
Sbjct: 802 RGYILRYRLAGLPGEYQQR-NITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAV 860
Query: 976 TITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQF 1035
T + P PPQ V E ++S +I+ W P + NGI +GY++
Sbjct: 861 TEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTV 920
Query: 1036 NIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENV 1095
I+ D G + + NL KFT Y V G GP S + T ED P ++
Sbjct: 921 VTIAPDFHGVHHGH-ITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPG-AVGHL 978
Query: 1096 QAIATSPESISISWSTLSKEALNGILQGFRV---IYWANLMDGELGEIKNITTTQPSLEL 1152
S+ +SW ++ NGI+ G+++ +Y N D L N TT + ++
Sbjct: 979 SFTEILDTSLKVSWQEPLEK--NGIITGYQISWEVYGRN--DSRLTHTLNSTTHE--YKI 1032
Query: 1153 DGLEKYTNYSIQVLAFTRAGDG-VRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLP 1211
GL T Y+I V A T G G V S I + D+PG P+ + + S + + P
Sbjct: 1033 QGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRP 1092
Query: 1212 PLKLNGIIRKYTV------FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVT 1265
I ++ V + E E PD+ IPNL+ Y + V
Sbjct: 1093 GYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVN 1152
Query: 1266 SAGRGNSSEIITVEPLAKAPARILTFSGTVTT 1297
G S V +AP + S TV T
Sbjct: 1153 IVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRT 1184
Score = 169 bits (428), Expect = 3e-41
Identities = 101/372 (27%), Positives = 182/372 (48%), Gaps = 26/372 (6%)
Query: 877 IIQLTVQEPPDPPE---IEIKDVKARTITLRWTMGFDGNSPITGYDIECKN-KSDSWDSA 932
+I +E P PP + +V AR++ L+W G DG SPI + ++ + W +
Sbjct: 1468 VITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTY 1527
Query: 933 QRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEL-TITADEAAPDGPPQEV 991
+ +S + + + + P ++Y +R+ A N IG S+ S+E +T + P PP V
Sbjct: 1528 --SSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSV 1585
Query: 992 HLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYRE--YSTGGNFQFNII----------- 1038
P ++ S+ + W+ P+ NG+++GY+I YRE Y G + +
Sbjct: 1586 SATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELT 1645
Query: 1039 ------SVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPP 1092
+V++S S + L +L K+ +Y +++ A N G P+S + E P+ P
Sbjct: 1646 AQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAP 1705
Query: 1093 ENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLEL 1152
+NVQ + + ++W E+ NG +QG+++ YW E ++K + +P + L
Sbjct: 1706 QNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRL 1765
Query: 1153 DGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPP 1212
L +T Y + + AF AGDG +S+ RT + PG P+ + + +++ + VSW P
Sbjct: 1766 KNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEP 1825
Query: 1213 LKLNGIIRKYTV 1224
NGI++ Y V
Sbjct: 1826 AAANGILQGYRV 1837
Score = 165 bits (417), Expect = 5e-40
Identities = 156/574 (27%), Positives = 257/574 (44%), Gaps = 59/574 (10%)
Query: 885 PPD----PPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECK----NKSDSWDSAQRTK 936
PPD P + I ++ R+ TL++ G+DG + I+ + +E + + W + +
Sbjct: 1066 PPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEE 1125
Query: 937 DVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKS--EPSNELTITADEAAPDGPPQEVHLE 994
+ P I ++ P + Y RM N +G S PS+ + T +A PD P V +
Sbjct: 1126 N-EPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTL-QAPPDVAPTSVTVR 1183
Query: 995 PISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSE-VYTLDN 1053
S S+R+ W NG +GYR + Q + ++ S E +T++
Sbjct: 1184 TASETSLRLRWVPLPDSQYNG--NPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEE 1241
Query: 1054 LNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLS 1113
L ++ +Y L +QA N G GP S+ + T E VPS PENV A A S I ++W+++
Sbjct: 1242 LEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVP 1301
Query: 1114 KEALNGILQGFRVIYWANLMDGE-LGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAG 1172
++ NG++ G+++++ A +D E I TQ +L L GL K+ Y +QVLAFTR G
Sbjct: 1302 EQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSAL-LAGLRKFVLYELQVLAFTRIG 1360
Query: 1173 DGVRSEQ-IFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVF--CSHP 1229
+GV S I RTK+D PGPP + + V + W PP + NGII Y + +
Sbjct: 1361 NGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASS 1420
Query: 1230 YPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSE--IITVEPLAK-APA 1286
P + E + +L+ Y + A T G G E +IT E + AP
Sbjct: 1421 SPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPP 1480
Query: 1287 RILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTID--------GRRSI 1338
R ++++P V S ++W+ S+G + G
Sbjct: 1481 R--------------ELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQT 1526
Query: 1339 FSNG------SFIIRTVKAEDSGYYSCIANNNWG----SDEIILNLQVQVPPDQPRLTVS 1388
+S+ + ++ ++ S A N+ G S E +Q P +P +VS
Sbjct: 1527 YSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVS 1586
Query: 1389 KT--TSSSITLSWLP--GDNGGSSIRGYILQYSE 1418
T T+SS+ + W P ++ ++GY + Y E
Sbjct: 1587 ATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRE 1620
Score = 160 bits (404), Expect = 2e-38
Identities = 165/657 (25%), Positives = 266/657 (40%), Gaps = 71/657 (10%)
Query: 877 IIQLTVQEPPDPP-EIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRT 935
I++ T + P PP + +V+ ++ + W + N I GY I + S S T
Sbjct: 1369 ILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSS-PHTFTT 1427
Query: 936 KDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQE--VHL 993
+V + T D+ P S Y R+ AK R G EP IT ++ PP+E V
Sbjct: 1428 VEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQ 1487
Query: 994 EPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDN 1053
++++S+R+ W IR + + RE G ++ S S ++ +D
Sbjct: 1488 AEVTARSLRLQWVPGSDGASP--IRYFTMQVRELPRG---EWQTYSSSISHEATACVVDR 1542
Query: 1054 LNKFTQYGLVVQACNRAGTGPSSQEI-ITTTLEDVPSYPPENVQAIATSPESISISWSTL 1112
L FT Y L ++A N G S E TTL+DVP PP +V A + S+ I W
Sbjct: 1543 LRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPP 1602
Query: 1113 SKEALNGILQGFRVIY----------------------WANLMDGELGEIKNITTTQPSL 1150
E+LNG+LQG+R+ Y A L + N ++T
Sbjct: 1603 RDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMC 1662
Query: 1151 ELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG-PPAGVKAAAASASMVFVSW 1209
EL L+KY Y + + A+ G+ S + E P P V+ +AS + V+W
Sbjct: 1663 ELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTW 1722
Query: 1210 --LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSY------RIPNLSRNRQYSVWV 1261
PP NG I+ Y ++ Y S+ E + R+ NL+ + +Y V +
Sbjct: 1723 DPPPPESQNGNIQGYKIY----YWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSI 1778
Query: 1262 VAVTSAGRGNSSEIITVEPLAKAPAR--ILTFSG----TVTTPW-----MKDIVLPCKAV 1310
A +AG G S+ AP L FS T+ W I+ + V
Sbjct: 1779 SAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVV 1838
Query: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
+P V+ G +VT++ R + +R + + ++ A E+
Sbjct: 1839 YEPLAPVQ------GVSKVVTVEVRGNW--QRWLKVRDLTKGVTYFFRVQARTITYGPEL 1890
Query: 1371 ILNLQV---QVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSF 1427
N+ + P PR + ++S +TL W G +G + GY+++ + W F
Sbjct: 1891 QANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMF 1950
Query: 1428 ----PISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKE 1480
P S + + L+ L+ G Y+F + A N G G S A + E F +E
Sbjct: 1951 VKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVEAPFYEE 2007
Score = 138 bits (347), Expect = 6e-32
Identities = 299/1532 (19%), Positives = 568/1532 (37%), Gaps = 200/1532 (13%)
Query: 136 MRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNY 195
+ GN V C+ S + W +D L + S S I +Q D + Y
Sbjct: 117 LEGNRLVLTCLAEGS---WPLEFKWMRDDSELTTYS-----SEYKYIIPSLQKLDAGF-Y 167
Query: 196 RCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELP--CKALGHPE 253
RC+ R+R ++ + ++ S +D D RK ++ R + +P
Sbjct: 168 RCVVRNRMGALLQRKSEVQVAYMG------SFMDT-DQRKTVSQGRAAILNLLPITSYPR 220
Query: 254 PDYRWLKDNMPLELSGRFQKTVTG-LLIENIRPSDSGSYVCEVSNR------------YG 300
P W ++ + S R T+ L+I SD+G+Y + N
Sbjct: 221 PQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLS 280
Query: 301 TAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSC--SVTGTEDQELSWYRNGEILNPGK 358
A+ +G P + + S+ +L C S ED ++W RNG
Sbjct: 281 IARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNG------- 333
Query: 359 NVRITGINHE---NLIMDHMVKSDGGAYQCFVRK-----DKLSAQDYVQVVLEDGTPKII 410
VRIT H L + + +D G Y C + A ++ ++ P
Sbjct: 334 -VRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFII----EPPYF 388
Query: 411 SAFSEKVVSPA--EPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSY 468
+A E +S E V + C G PLPT+ W D I + + R +++ S G
Sbjct: 389 TAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRY-KVLASGG----- 442
Query: 469 LNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI---RPMKNITAIAGRDTYIHC 525
L I + D G+++C A+N G + ++V A + RP+ + T G + C
Sbjct: 443 LRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPV-DTTVTDGMTAILRC 501
Query: 526 RVIGYPYYSIKWYKNSNLLPFNHRQVA---FENNGTLKLSDVQKEVDEGEYTCNVL-VQP 581
V G P +I W + +++L ++ +G L+++ V + D G YTC +
Sbjct: 502 EVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQ-DAGNYTCYAANTEG 560
Query: 582 QLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGD-LPITITWQKDGRPI-PG 639
L+ S ++ V + + P E G + C + + W+KD + P
Sbjct: 561 SLNASATLTVWNRTS-IVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPS 619
Query: 640 SLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV----RVPPKFVVQ 695
S + ++ SL IS G+Y+C +E ++L V P +V
Sbjct: 620 STSRIV--VEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVS 677
Query: 696 PRDQDGIYGKAVILNCSAE---GYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLL 752
P + AV+L+ P+ + + S+ + + + ++ L
Sbjct: 678 PNSS---HSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLT 734
Query: 753 IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAH 812
+ + +C V N+VG + + +P S P + G+ +
Sbjct: 735 PARTYQ----FRVCAV-NEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQS----- 784
Query: 813 GEKPIIVRWE-----KEDRIINPEMARYL------------VSTKEVGEEVISTLQILPT 855
I+V+W+ + + ++ + RY +++ EV +++ L I
Sbjct: 785 ----IMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQ 840
Query: 856 VREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPI 915
++ + + R + + T+Q P P ++ + T+++ I
Sbjct: 841 YEIQVAAYNGAGLGVFS--RAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFI 898
Query: 916 TGYDIECKNKSDSWDSAQRTK--DVSPQLNSAT---IIDIHPSSTYSIRMYAKNRIGKSE 970
G + K + D+ + ++P + I ++ + Y + G
Sbjct: 899 NGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGP 958
Query: 971 PSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTG 1030
PS + E P G + I S++V+W+ P + +NGII GYQI + Y
Sbjct: 959 PSTPQLVWTQEDKP-GAVGHLSFTEILDTSLKVSWQEPLE--KNGIITGYQISWEVYGRN 1015
Query: 1031 GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLE-DVPS 1089
+ + ++ T Y + L+ T Y + V A GTG + I++ + D+P
Sbjct: 1016 DSRLTHTLNSTT----HEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPG 1071
Query: 1090 YPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKN----ITT 1145
P N+ SP S ++ + G + W +++G++G I + +T
Sbjct: 1072 -APSNLVISNISPRSATLQFRP-------GYDGKTSISRW--IVEGQVGAIGDEEEWVTL 1121
Query: 1146 TQPS-------LELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPP----AG 1194
+ LE+ L YT+Y ++ G S +R + + PP
Sbjct: 1122 YEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPS--SRVIQTLQAPPDVAPTS 1179
Query: 1195 VKAAAASASMVFVSW--LPPLKLNG----IIRKYTVFCSHPYPTVISEFEASPDSFSYRI 1248
V AS + + + W LP + NG + + + S + +++ + + I
Sbjct: 1180 VTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTI 1239
Query: 1249 PNLSRNRQYSVWVVAVTSAGRGNSSEII--------------TVEPLAKAPARILTFSGT 1294
L +Y + + A + G G SE++ V A + +IL +
Sbjct: 1240 EELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTS 1299
Query: 1295 VTTPWMKDIVLPCKAVG-----DPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTV 1349
V ++L K + DP P ++ N T S + R+ + +
Sbjct: 1300 VPEQDQNGLILGYKILFRAKDLDPEPRSHIVR-GNHTQSALLAGLRKFVLYELQVLA--- 1355
Query: 1350 KAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSI 1409
++ I N + I+ + P RL + +S+ + W P + I
Sbjct: 1356 -------FTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGII 1408
Query: 1410 RGYILQY--SEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIE 1467
GY + Y + + + + + + R + +L + Y F L+A+ G G E
Sbjct: 1409 LGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATV 1468
Query: 1468 AKTLGKEPQFSKEQELF--ASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTT-- 1523
T +E + L A + +RL + +DG PI FT++ R W T
Sbjct: 1469 ITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYS 1528
Query: 1524 AQRTSLSKSYILYDLQEATWYELQMRVCNSAG 1555
+ + + + ++ L+ T Y+L+++ N G
Sbjct: 1529 SSISHEATACVVDRLRPFTSYKLRLKATNDIG 1560
Score = 123 bits (309), Expect = 2e-27
Identities = 114/493 (23%), Positives = 197/493 (39%), Gaps = 23/493 (4%)
Query: 100 YYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
Y C N G + + ++ + + + +G A+ + +S V+
Sbjct: 167 YRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTVSQGRAAILNLLPITSYPR--PQVT 224
Query: 160 WEKDTVSLVSGSRFLITSTGALYIKDVQNED-GLYNYRCITRHRYTGETRQSNSARLFVS 218
W ++ ++ +R IT L I D G Y + + GE + S L ++
Sbjct: 225 WFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQAVNEKN--GENKTSPFIHLSIA 282
Query: 219 ----DPANSAPSILDGFDHRKAMAGQ-RVELPCKALGHPEPDYRWLKDNMPLELSGRFQK 273
P AP+I+ +R +AG L C A P D + ++
Sbjct: 283 RDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPVEDLSVTWKRNGVRITSGLHS 342
Query: 274 TVTGLLIENIRPSDSGSYVCEVS---NRYGTAKVIGRLYVKQPLKATISPR-KVKSSVGS 329
L I N +D+G YVCE + + + A+ L++ +P T P ++ + V
Sbjct: 343 FGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEE 402
Query: 330 QVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK 389
V + C G L WY++ ++ +N R + L + + D G +QCF
Sbjct: 403 TVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASN 462
Query: 390 DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILK 449
+ Q + + + + P + V+ L C V G P P ITW ++ IL
Sbjct: 463 EGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENH-ILA 521
Query: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI-R 508
GS RI + + E L I+ ++D G Y C A N+ G + A + V SI
Sbjct: 522 SGSVRIPRFMLLES---GGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRTSIVH 578
Query: 509 PMKNITAIAGRDTYIHCRVIGYPYYSIK--WYK-NSNLLPFNHRQVAFENNGTLKLSDVQ 565
P ++ I G +HC P S++ W K N L P + ++ E +G+L +S
Sbjct: 579 PPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTW 638
Query: 566 KEVDEGEYTCNVL 578
D G+Y+C ++
Sbjct: 639 SG-DIGDYSCEIV 650
Score = 117 bits (294), Expect = 9e-26
Identities = 139/616 (22%), Positives = 252/616 (40%), Gaps = 57/616 (9%)
Query: 891 IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKD-VSPQLNSAT--- 946
+ ++ ++ + W + N ITGY I SW+ R ++ LNS T
Sbjct: 978 LSFTEILDTSLKVSWQEPLEKNGIITGYQI-------SWEVYGRNDSRLTHTLNSTTHEY 1030
Query: 947 -IIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTW 1005
I + +TY+I + A +G ++ + G P + + IS +S + +
Sbjct: 1031 KIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQF 1090
Query: 1006 KAP---KKHLQNGIIRGYQIGYREYSTGGNFQF-NIISVDTSGDSEVYTLDNLNKFTQYG 1061
+ K + I+ G Q+G + G ++ + + D+++ + NL +T Y
Sbjct: 1091 RPGYDGKTSISRWIVEG-QVG----AIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYR 1145
Query: 1062 LVVQACNRAGTGP-SSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGI 1120
++ N G P S + TL+ P P +V S S+ + W L NG
Sbjct: 1146 FRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGN 1205
Query: 1121 LQ--GFRVIYW-ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRS 1177
+ G+R+ YW ++L + ++ + + ++ LE++ Y +Q+ AF G G S
Sbjct: 1206 PESVGYRIKYWRSDLQSSAVAQVVS-DRLEREFTIEELEEWMEYELQMQAFNAVGAGPWS 1264
Query: 1178 EQIFTRTKEDVPGP-PAGVKAAAASASMVFVSW--LPPLKLNGIIRKYTVF--CSHPYPT 1232
E + RT+E VP P V A A S++ + ++W +P NG+I Y + P
Sbjct: 1265 EVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPE 1324
Query: 1233 VISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPL---AKAPARIL 1289
S + S + L + Y + V+A T G G S + +E A P L
Sbjct: 1325 PRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRL 1384
Query: 1290 TFSGTVTTPWMKDIVLPCKAVGDPSPAV-----KWMKDSNGTPSLVTIDGRRSIFSNGSF 1344
F T + + + +P+ + + S+ + T++ ++
Sbjct: 1385 VFPEVRLT----SVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQ---- 1436
Query: 1345 IIRTVKAEDSGYY---SCIANNNWGS--DEIILNLQVQVPPDQPR---LTVSKTTSSSIT 1396
T A +S Y S WG + ++ + + P PR + ++ T+ S+
Sbjct: 1437 FTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLR 1496
Query: 1397 LSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYR--LENLKCGTWYKFTLTAQ 1454
L W+PG +G S IR + +Q E +W ++ S S + ++ L+ T YK L A
Sbjct: 1497 LQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKAT 1556
Query: 1455 NGVGPGRISEIIEAKT 1470
N +G S EA T
Sbjct: 1557 NDIGDSDFSSETEAVT 1572
Score = 116 bits (290), Expect = 3e-25
Identities = 205/928 (22%), Positives = 335/928 (36%), Gaps = 164/928 (17%)
Query: 888 PPEIEIKDVKARTITLRWTM--GFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSA 945
P + + V + I L WT D N I GY I R KD+ P+ S
Sbjct: 1280 PENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKI-----------LFRAKDLDPEPRSH 1328
Query: 946 TIIDIHPSST----------YSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEP 995
+ H S Y +++ A RIG PS L + + GPP +
Sbjct: 1329 IVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPE 1388
Query: 996 ISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLN 1055
+ S+R+ W+ P++ NGII GYQI YR S+ + +V+ +T +L
Sbjct: 1389 VRLTSVRIVWQPPEE--PNGIILGYQIAYRLASSSPH---TFTTVEVGATVRQFTATDLA 1443
Query: 1056 KFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENV--QAIATSPESISISWSTL 1112
+ Y + A R G G P +ITT + P+ P E + QA T+ S+ + W
Sbjct: 1444 PESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTA-RSLRLQWVPG 1502
Query: 1113 SKEALNGILQGFRVIYWANLMDGEL--GEIK----NITTTQPSLELDGLEKYTNYSIQVL 1166
S G I + + EL GE + +I+ + +D L +T+Y +++
Sbjct: 1503 S--------DGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLK 1554
Query: 1167 AFTRAGDG-VRSEQIFTRTKEDVPG-PPAGVKAAAASASMVFVSWLPPL--KLNGIIRKY 1222
A GD SE T +DVPG PP V A + S V + W PP LNG+++ Y
Sbjct: 1555 ATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGY 1614
Query: 1223 TVF---------------------CSHPYPTVISEFE---ASPDSFSYRIPNLSRNRQYS 1258
++ H T S F+ +S S + +L + R+Y
Sbjct: 1615 RIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYE 1674
Query: 1259 VWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVK 1318
V + A G +S + V APA + TP + + DP P
Sbjct: 1675 VIMTAYNIIGESPASAPVEVFVGEAAPA--MAPQNVQVTPLTASQL---EVTWDPPPPES 1729
Query: 1319 ------------WMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
W DS + + +F + + Y I+ N
Sbjct: 1730 QNGNIQGYKIYYWEADSQNETEKMKV-----LFLPEPVVRLKNLTSHTKYLVSISAFNAA 1784
Query: 1367 SDEIILNLQV----QVPPDQPR-LTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNS 1421
D + Q Q P P L S+ TS+++ +SW ++GY + Y
Sbjct: 1785 GDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAP 1844
Query: 1422 EQWGSFPISPS-----ERSYRLENLKCGTWYKFTLTAQN-GVGPGRISEIIEAKTLGKEP 1475
Q S ++ +R ++ +L G Y F + A+ GP + I G
Sbjct: 1845 VQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSP- 1903
Query: 1476 QFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVW----TTAQRTSLSK 1531
+++ + + + + L + G P T + +E RP +W R++ S
Sbjct: 1904 --GSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSY 1961
Query: 1532 SYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNE 1591
+ L L++ YE ++ N AG E P Q E
Sbjct: 1962 TLSLDKLRQGVTYEFRVVAVNEAGYGEPS-------------NPSTAVSAQVEAPFYEEW 2008
Query: 1592 GLKMLVTISCILVGVLLLFVLLLVVRRRRREQRLKRLRDAKSLAEM-------------- 1637
+++ +S ++V +L++F L+L + ++ K K ++ M
Sbjct: 2009 WFLLVMALSSLIVILLVVFALVL----HGQNKKYKNCSTGKGISTMEESVTLDNGGFAAL 2064
Query: 1638 -LMSKNTRTSDTLSKQQQTLRMHIDIP--------------RAQLLIEERDTMETIDDRS 1682
L S++ T SK+ T P +L E E D S
Sbjct: 2065 ELSSRHLNVKSTFSKKNGTRSPPRPSPGGLHYSDEDICNKYNGAVLTESVSLKEKSADAS 2124
Query: 1683 TVLLTDADFGEAAKQKSLTVTHTVHYQS 1710
TD+D+ +A + S HY S
Sbjct: 2125 ESEATDSDYEDALPKHSF----VNHYMS 2148
Score = 68.2 bits (165), Expect = 8e-11
Identities = 76/299 (25%), Positives = 118/299 (39%), Gaps = 38/299 (12%)
Query: 44 VPCPAAGIPPVTLRWYLATGEEIYDVPGIRH----VHPNGTLQIFPFPPSSFSTLIHDNT 99
+ C A G+P TL+WY ++ + +++ V +G L+I P
Sbjct: 406 IGCQAMGVPLPTLQWY----KDAISISRLQNPRYKVLASGGLRIQKLRPED------SGI 455
Query: 100 YYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
+ C A N G+I++ + +T R D G A+ +C + + + IT
Sbjct: 456 FQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAIT--- 512
Query: 160 WEKDTVSLVSGS----RFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARL 215
W+++ L SGS RF++ +G L I V +D NY C Y T S +A
Sbjct: 513 WKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDA-GNYTC-----YAANTEGSLNASA 566
Query: 216 FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPD--YRWLKDNMPLELSGRFQK 273
++ + SI+ + + G L C A P Y W KDN+ L S +
Sbjct: 567 TLT--VWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTSRI 624
Query: 274 TVT---GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYV----KQPLKATISPRKVKS 325
V LLI D G Y CE+ + G + RL V P +SP S
Sbjct: 625 VVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHS 683
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 270 bits (690), Expect = 1e-71
Identities = 267/1014 (26%), Positives = 421/1014 (41%), Gaps = 114/1014 (11%)
Query: 535 IKWYKNSNLLPFNHRQVAFE-NNGTLKLSDV----QKEVDEGEYTCNVLVQPQLST-SQS 588
IKW K+ L + + +NG+L + ++ + DEG Y C + S S++
Sbjct: 72 IKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISRT 131
Query: 589 VHVTVKVP-PFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQK---DGRPIPGSLGVT 644
V V P F+ E +G V + C V+ +P TI WQK D PIPG V
Sbjct: 132 AKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMP-TIHWQKNQQDLTPIPGDSRVV 190
Query: 645 IDNIDFTSSLRISNLSLMHNGNYTCIARNEAAA-VEHQSQLIVRVPPK------FVVQPR 697
+ + +L+IS L G Y C ARN A++ +++++ + P F+ +P
Sbjct: 191 VLP---SGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPS 247
Query: 698 DQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVV 757
+ I GK +L C GYP P+ W +G V Q + + + +L +LLI +V
Sbjct: 248 NVVAIEGKDAVLECCVSGYPPPSFTWL--RGEEVIQLR----SKKYSLLGGSNLLISNVT 301
Query: 758 EEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPI 817
++DSG Y C V+ ++S S LTV +P ++P+ A + E CT G+
Sbjct: 302 DDDSGMYTCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVP 360
Query: 818 IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGI 877
V W K ++ P +V S L+IL V+ D GF+ C A N G +
Sbjct: 361 TVNWMKNGDVVIPSDYFQIVGG--------SNLRILGVVKSDEGFYQCVAENEAGNAQTS 412
Query: 878 IQLTVQEPPDPPEIEIKD---------VKARTITLRWTMGFDGNSPITGYDIECKNKSDS 928
QL V +P P + V +R + L W + I + + + D+
Sbjct: 413 AQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDN 472
Query: 929 WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTI-TADEAAPDGP 987
+ A T P T+ ++ P + Y+ R+ A N G E S + + T E GP
Sbjct: 473 RERALNT--TQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGP 530
Query: 988 PQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSE 1047
+ + S SI +TW+ P NG ++GY++ E STG + D
Sbjct: 531 VENLQAVSTSPTSILITWEPPA--YANGPVQGYRLFCTEVSTGKEQNIEV-------DGL 581
Query: 1048 VYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISI 1107
Y L+ L KFT+Y L A NR G G S+ +I TL DVPS PP+NV + SI +
Sbjct: 582 SYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKV 641
Query: 1108 SWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPS---LELDGLEKYTNYSIQ 1164
SW NG + G+++ + GE+ T +P+ GLEK + YS Q
Sbjct: 642 SWLPPPSGTQNGFITGYKIRHRKTTRRGEM------ETLEPNNLWYLFTGLEKGSQYSFQ 695
Query: 1165 VLAFTRAGDGVRSEQIFTRTKED------VPGPPAGVKAAAASASMVFVSWLPPLKLNGI 1218
V A T G G S T E+ VP P+ + + + +SW PPL N +
Sbjct: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLH-VRPQTNCIIMSWTPPLNPNIV 754
Query: 1219 IRKYTV--FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRG------ 1270
+R Y + PY + Y I L + Y + + A +AG G
Sbjct: 755 VRGYIIGYGVGSPYAETV---RVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYES 811
Query: 1271 NSSEIIT--VEPLAKAPA--RILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDS--- 1323
++ IT +P+ P T ++TP + + + A+ + V W +S
Sbjct: 812 ATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPK 871
Query: 1324 ---NGTPSLVTIDGRRSIFSNG----------SFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
L T+ R S ++ S+ +K +S + N S
Sbjct: 872 NQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTW 931
Query: 1371 ILNLQV----QVPPDQPR-LTV--SKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNS-- 1421
+ P P+ LTV + ++ +SW P I YIL Y+ D +
Sbjct: 932 SMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIP 991
Query: 1422 -EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474
+ W IS ++++ +L T Y F + A+N G G +S+ I +TL E
Sbjct: 992 IDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLKVE 1045
Score = 174 bits (442), Expect = 6e-43
Identities = 245/1047 (23%), Positives = 398/1047 (38%), Gaps = 123/1047 (11%)
Query: 314 LKATISPRKVKSSVGSQVSLSCSVTGTEDQE-LSWYRNGEILNPGKNVRITGINHENLIM 372
L+ P + G V L CS + W ++G L G + R +++ +L++
Sbjct: 40 LRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLI 99
Query: 373 DHMV-----KSDGGAYQCFVRK-DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSL 426
+++ K D G YQC D S V G + +S + V L
Sbjct: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
Query: 427 MCNVKGTPLPTITWTLDDDPILK-GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485
C V G P+PTI W + + G R+ + + L IS Q D G+YRC+
Sbjct: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGA------LQISRLQPGDIGIYRCS 213
Query: 486 ANNSAGVVL-YQARINVRGPASI--------RPMKNITAIAGRDTYIHCRVIGYPYYSIK 536
A N A +A + + + RP N+ AI G+D + C V GYP S
Sbjct: 214 ARNPASSRTGNEAEVRILSDPGLHRQLYFLQRP-SNVVAIEGKDAVLECCVSGYPPPSFT 272
Query: 537 WYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVP 596
W + ++ ++ + L +S+V + D G YTC V+ + S S +TV VP
Sbjct: 273 WLRGEEVIQLRSKKYSLLGGSNLLISNVTDD-DSGMYTC-VVTYKNENISASAELTVLVP 330
Query: 597 PFI--QPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSL 654
P+ P + + C V +P T+ W K+G + S I S+L
Sbjct: 331 PWFLNHPSNLYAYE-SMDIEFECTVSGKPVP-TVNWMKNGDVVIPS---DYFQIVGGSNL 385
Query: 655 RISNLSLMHNGNYTCIARNEAAAVEHQSQLIV---RVPPKFVV--QPRDQDGIYGKAVIL 709
RI + G Y C+A NEA + +QLIV +P V+ PRD + + +
Sbjct: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFV 445
Query: 710 NCS------AEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY 763
S A+G V+ +G + G +Q L + ++ E
Sbjct: 446 RLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQ------LTVGNLKPEAMYT 499
Query: 764 YLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK 823
+ N+ G S P + + P L G + + + I++ WE
Sbjct: 500 FRVVAYNEWGPGESSQ-------PIKVATQPE--LQVPGPVENLQAVSTSPTSILITWEP 550
Query: 824 EDRIINPEMARYLVST-----KEVGEEVISTLQILPTVREDSGF-FSCHAINSYG----- 872
P L T KE EV L +++ + + A N YG
Sbjct: 551 PAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVST 610
Query: 873 EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDG--NSPITGYDIECKNKSDSWD 930
+D ++ L+ P + ++ V +R+I + W G N ITGY I + + +
Sbjct: 611 DDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGE 670
Query: 931 SAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITA-----DEAAPD 985
+ + P + S YS ++ A G PSN T DE+
Sbjct: 671 ----METLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVP 726
Query: 986 GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGD 1045
P +H+ P + I ++W P N ++RGY IGY G+ + VD+
Sbjct: 727 DQPSSLHVRP-QTNCIIMSWTPPLN--PNIVVRGYIIGYGV----GSPYAETVRVDSK-- 777
Query: 1046 SEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITT--------------TLEDVPS-- 1089
Y+++ L + Y + ++A N AG G E TT L+D P+
Sbjct: 778 QRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSV 837
Query: 1090 -------YPPENVQAIATSPESISISW--STLSKEALNGILQGFRVIYWANLMDGELGEI 1140
PP VQA+A + +++ +SW +++ K ++ + + W +
Sbjct: 838 PDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLY-TVRWRTSFSAS-AKY 895
Query: 1141 KNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP-GPPAGVKAAA 1199
K+ TT S GL+ T Y V+ S T E P P +
Sbjct: 896 KSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVIT 955
Query: 1200 ASAS--MVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEF---EASPDSFSYRIPNLSRN 1254
V VSW PPL+ NG I Y +F + I ++ S D +++I +L+ +
Sbjct: 956 REGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLD 1015
Query: 1255 RQYSVWVVAVTSAGRGNSSEIITVEPL 1281
Y + A S G G S+ I L
Sbjct: 1016 TMYYFRIQARNSKGVGPLSDPILFRTL 1042
Score = 102 bits (254), Expect = 4e-21
Identities = 102/429 (23%), Positives = 172/429 (40%), Gaps = 30/429 (6%)
Query: 97 DNTYYCTAE-NPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYI 155
+ Y C A SG I S+ + + + E G+ + KC + + +
Sbjct: 112 EGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEV---IGEPM 168
Query: 156 TVVSWEK---DTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNS 212
+ W+K D + SR ++ +GAL I +Q D + YRC R+ + T
Sbjct: 169 PTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGD-IGIYRCSARNPASSRTGNEAE 227
Query: 213 ARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQ 272
R+ + L + A+ G+ L C G+P P + WL+ ++L +
Sbjct: 228 VRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKY 287
Query: 273 KTVTG--LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQ 330
+ G LLI N+ DSG Y C V+ + L V P P + +
Sbjct: 288 SLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMD 347
Query: 331 VSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKD 390
+ C+V+G ++W +NG+++ P +I G NL + +VKSD G YQC +
Sbjct: 348 IEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVG--GSNLRILGVVKSDEGFYQCVAENE 405
Query: 391 KLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKG 450
+AQ Q+++ PK A V P+ P ++ + + ++W + KG
Sbjct: 406 AGNAQTSAQLIV----PK--PAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAE--AKG 457
Query: 451 GSHRISQMITSEG-NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARI---NVRGPA- 505
+ + EG N LN + G + T N +Y R+ N GP
Sbjct: 458 NIQTFTVFFSREGDNRERALNTTQP-----GSLQLTVGNLKPEAMYTFRVVAYNEWGPGE 512
Query: 506 SIRPMKNIT 514
S +P+K T
Sbjct: 513 SSQPIKVAT 521
Score = 72.8 bits (177), Expect = 3e-12
Identities = 97/429 (22%), Positives = 173/429 (40%), Gaps = 31/429 (7%)
Query: 1149 SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTR-----TKEDVPGPPAGVKAAAASAS 1203
+L + G+ K Q +A AG+ S Q+ + +P P V S+
Sbjct: 384 NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSR 443
Query: 1204 MVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEAS-PDSFSYRIPNLSRNRQYSVWVV 1262
V +SW PP + G I+ +TVF S + P S + NL Y+ VV
Sbjct: 444 FVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVV 503
Query: 1263 AVTSAGRGNSSEIITV--EPLAKAPARILTFSGTVTTPWMKDIVL--PCKAVGDPSPAVK 1318
A G G SS+ I V +P + P + T+P I P A G
Sbjct: 504 AYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRL 563
Query: 1319 WMKD-SNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG----SDEIILN 1373
+ + S G + +DG S+ + +K +A N +G +D+I +
Sbjct: 564 FCTEVSTGKEQNIEVDGL-------SYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVV 616
Query: 1374 LQVQVPPDQPR-LTVSKTTSSSITLSWLPGDNGGSS--IRGYILQYSEDNSEQWGSFPIS 1430
VP P+ +++ S SI +SWLP +G + I GY +++ + + + +
Sbjct: 617 TLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRK-TTRRGEMETLE 675
Query: 1431 PSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINT- 1489
P+ Y L+ G+ Y F ++A G G S A+T + S+ + +S++
Sbjct: 676 PNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVR 735
Query: 1490 TRVRLNLIGWNDGGCP---ITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYEL 1546
+ ++ W P + + + Y G+ T + S + Y + L+ ++ Y +
Sbjct: 736 PQTNCIIMSWTPPLNPNIVVRGYIIGY-GVGSPYAETVRVDSKQRYYSIERLESSSHYVI 794
Query: 1547 QMRVCNSAG 1555
++ N+AG
Sbjct: 795 SLKAFNNAG 803
Score = 68.6 bits (166), Expect = 6e-11
Identities = 74/269 (27%), Positives = 106/269 (39%), Gaps = 25/269 (9%)
Query: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
DI C G P P V WMK+ + +V I + I V D G+Y C+A
Sbjct: 347 DIEFECTVSGKPVPTVNWMKNGD----VVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVA 402
Query: 1362 NNNWGSDEIILNLQVQVP--------PDQPRLTVSKTTSSS-ITLSWLPGDNGGSSIRGY 1412
N G+ + L V P P PR V SS + LSW P +I+ +
Sbjct: 403 ENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTF 462
Query: 1413 ILQYS-EDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTL 1471
+ +S E ++ + P + NLK Y F + A N GPG S+ I+ T
Sbjct: 463 TVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVAT- 521
Query: 1472 GKEPQFSKEQELFASINTTRVRLNLIGWND---GGCPITSFTLEYRPFGTTVWTTAQRTS 1528
E Q E +++T+ + LI W P+ YR F T V T ++
Sbjct: 522 QPELQVPGPVENLQAVSTSPTSI-LITWEPPAYANGPVQG----YRLFCTEVSTGKEQNI 576
Query: 1529 L--SKSYILYDLQEATWYELQMRVCNSAG 1555
SY L L++ T Y L+ N G
Sbjct: 577 EVDGLSYKLEGLKKFTEYSLRFLAYNRYG 605
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 252 bits (643), Expect = 3e-66
Identities = 340/1513 (22%), Positives = 575/1513 (38%), Gaps = 203/1513 (13%)
Query: 50 GIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSG 109
G P+T+ W L +EI + IR N ++ S + HD Y C A+N +G
Sbjct: 4511 GSLPITVTW-LKDSDEITEDDNIRMTFENNVASLY----LSGIEVKHDGKYVCQAKNDAG 4565
Query: 110 KIRSQDVHIKAVLREPYTVRVEDQK--TMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSL 167
R + ++EP T+ E +G+ A + + E W KD L
Sbjct: 4566 IQRCSAL---LSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEI---TAKWFKDGQEL 4619
Query: 168 VSGSRFLITSTGALYIKDV----QNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANS 223
GS++ I+ T + I + + + G Y + R S AR+ V D
Sbjct: 4620 TLGSKYKISVTDTVSILKIISTEKKDSGEYTFEV-----QNDVGRSSCKARINVLDLI-I 4673
Query: 224 APSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGR----FQKTVTGLL 279
PS ++ G ++L C G +W KD+ + S + F L
Sbjct: 4674 PPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLE 4733
Query: 280 IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTG 339
I + +DSG+Y C +N+ G + G L VK+P P+ + ++V L V G
Sbjct: 4734 ISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGG 4793
Query: 340 TEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKS-DGGAYQCFVRKDKLSAQDYV 398
T + W+++ + L+ G + + + K+ D G Y C + D +A
Sbjct: 4794 TAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKA 4853
Query: 399 QVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQM 458
+ +++ I V+ + + C + GTP ++W LD + I H IS +
Sbjct: 4854 TLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFI 4913
Query: 459 ITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS-IRPMKNITAIA 517
+ ++ IS ++V + G Y C A N AG + V+ P + IR +K + +
Sbjct: 4914 -----DGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVK 4968
Query: 518 GRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV-DEGEYTCN 576
D + C V G P + + W KN+ + + + + L + + D GEY C
Sbjct: 4969 YSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQC- 5027
Query: 577 VLVQPQLSTSQSVHVTVKVPP-FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGR 635
++ S S S V +K PP FI+ E + V +G PI+ITW KD +
Sbjct: 5028 IVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTV-AGSPPISITWLKDDQ 5086
Query: 636 PIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ 695
+ V I +D ++L+I ++ H+G YTC A+NE+ + L+V+ P + V +
Sbjct: 5087 ILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEK 5146
Query: 696 PRDQDGIYGKAVILNCSAEGYPVPTIVW-KFSKGAGVPQFQPIALNGRIQVLSNGSLLIK 754
+ D + L C G P + W K K ++ ++ + S I+
Sbjct: 5147 AKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNV-----ASFRIQ 5201
Query: 755 HVVEEDSGYYLCKVSNDVGADVSKSMYLTV---KIPAMITSYPNTTLATQGQKKEMSCTA 811
V+++DSG Y KV ND G+ S YL V IP T G M C
Sbjct: 5202 SVMKQDSGQYTFKVENDFGSS-SCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKV 5260
Query: 812 HGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSY 871
G PI +W K+ + I+ LV + ++ L++ ED+ ++C N
Sbjct: 5261 SGSLPISAQWFKDGKEISTSAKYRLVCHERSVSLEVNNLEL-----EDTANYTCKVSNVA 5315
Query: 872 GEDRGIIQLTVQEPPDPPEIEIKDVKARTI---TLRWTMGFDGNSPITGYDIECKNKSDS 928
G+D LTV+EPP +K + + I T+ + G P + K D
Sbjct: 5316 GDDACSGILTVKEPPS---FLVKPGRQQAIPDSTVEFKAILKGTPPF-----KIKWFKDD 5367
Query: 929 WDSAQRTKDVSPQLNSATIIDIHP---SSTYSIRMYAKNRIGKSEPSNELTIT------- 978
+ K S + ++++ S T + N +G + L +T
Sbjct: 5368 VELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVK 5427
Query: 979 ---ADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQF 1035
A + G + + S IRV W + L Y++ + + + Q
Sbjct: 5428 KLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPAS--DKYRMTFID--SVAVIQM 5483
Query: 1036 NIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENV 1095
N +S + SGD + +A N AG+ S ++I S+PP V
Sbjct: 5484 NNLSTEDSGD----------------FICEAQNPAGSTSCSTKVIVKEPPVFSSFPP-IV 5526
Query: 1096 QAIATSPESISISWSTLSKEALNGILQGFRVIYWAN---LMDGELGEI--KNITTTQPSL 1150
+ + + S+ S F V+++ + L + +I KN T+ L
Sbjct: 5527 ETLKNAEVSLECELSGTPP---------FEVVWYKDKRQLRSSKKYKIASKNFHTSIHIL 5577
Query: 1151 ELD--GLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP--------------GPPAG 1194
+D + +Y +A + V S+ K P G PA
Sbjct: 5578 NVDTSDIGEY---------HCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAE 5628
Query: 1195 VKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNL--- 1251
++A+ A +FV WL + VI E E +F + L
Sbjct: 5629 LQASIEGAQPIFVQWLKEKE-----------------EVIRESENIRITFVENVATLQFA 5671
Query: 1252 -SRNRQYSVWVVAVTSAG--RGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCK 1308
+ ++ + + G R N + ++ +E PA I+ +G +T + L CK
Sbjct: 5672 KAEPANAGKYICQIKNDGGMRENMATLMVLE-----PAVIVEKAGPMTVTVGETCTLECK 5726
Query: 1309 AVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSN--GSFIIRTVKAEDSGYYSCIANNNWG 1366
G P +V+W KD L + + F N S I +V+ +D+G Y+ NN G
Sbjct: 5727 VAGTPELSVEWYKDGK---LLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVG 5783
Query: 1367 SDEIILNLQVQ---VPPDQPR--------------LTVSKTTSSSITLSWLPGDNGGSSI 1409
+ V VPP R L SS I+++W S
Sbjct: 5784 KSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSG 5843
Query: 1410 RGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAK 1469
Y +S++ + +L +L +T A N G ++
Sbjct: 5844 AKYQTTFSDNVC-------------TLQLNSLDSSDMGNYTCVAANVAGSDECRAVL--- 5887
Query: 1470 TLGKEPQFSKEQE 1482
T+ + P F KE E
Sbjct: 5888 TVQEPPSFVKEPE 5900
Score = 252 bits (643), Expect = 3e-66
Identities = 335/1403 (23%), Positives = 540/1403 (38%), Gaps = 192/1403 (13%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIR--HVHPNGTLQIFPFPPSSFSTLIHDNTYYCT 103
C G P+ + WY G + D ++ VH TLQI S H Y C+
Sbjct: 7137 CRINGSEPLQVSWY-KDGVLLKDDANLQTSFVHNVATLQILQTDQS------HIGQYNCS 7189
Query: 104 AENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAV-----FKCIIPSSVEAYITVV 158
A NP G S K +L E D K + ++A+ FKC + + IT
Sbjct: 7190 ASNPLGTASSS---AKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKIT-- 7244
Query: 159 SWEKDTVSLVSGSRF---LITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARL 215
W KD + G + L+ +T L + V D Y C + + S SA+L
Sbjct: 7245 -WAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDA-GQYTCYASNI---AGKDSCSAQL 7299
Query: 216 FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKT- 274
V +P + R + CK G PE W KD ++ S +F+ +
Sbjct: 7300 GVQEPPRFIKKLEPS---RIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSF 7356
Query: 275 ---VTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQV 331
V L + N+ DSG Y CE N G+A L VK+P P +++ G+ V
Sbjct: 7357 VDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADV 7416
Query: 332 SLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDG---GAYQCFVR 388
L C + GT +SWY++ L GK +I N I H++ D G YQC
Sbjct: 7417 HLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSI--HILNVDAADIGEYQCKAT 7474
Query: 389 KDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPIL 448
D + + V + P+ + S+ + V L ++G ++ W D I+
Sbjct: 7475 ND-VGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIV 7533
Query: 449 KGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI- 507
+ + + S ++ L S + + G Y C N AG+ A ++V PA+I
Sbjct: 7534 RESDN----IWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIV 7589
Query: 508 RPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR-QVAFENNGT-LKLSDVQ 565
++I G + C V G P S KW+K+ L +++ +++F N + LK+ +V
Sbjct: 7590 EKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVA 7649
Query: 566 KEVDEGEYTCNV---LVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSG 622
D G Y+ V + + + S V P F + + G V + C V G
Sbjct: 7650 PS-DSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVY-G 7707
Query: 623 DLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQS 682
PI+++W +G I D T +L ++ L +G+YTCIA N A + E +
Sbjct: 7708 SPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSA 7767
Query: 683 QLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGR 742
L VR PP FV +P D + G V +G P ++ W VP R
Sbjct: 7768 PLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVP-------GDR 7820
Query: 743 IQVLSNGSLLIKHVVEED---SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLA 799
V S+ + + D SG Y C VSN+ G S + +L +K PA N
Sbjct: 7821 CNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAG-KASCTTHLYIKAPAKFVKRLNDYSI 7879
Query: 800 TQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED 859
+G+ + T G PI V W+K + P + +T E + L+I + ED
Sbjct: 7880 EKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTT-----EKSAILEIPSSTVED 7934
Query: 860 SGFFSCHAINSYGEDRGIIQLTVQEPP------DPPEIEIKD--------VKARTITLRW 905
+G ++C+ N+ G+D Q+ + EPP +P ++ + D I + W
Sbjct: 7935 AGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSW 7994
Query: 906 TMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATI----IDIHPSSTYSIRMY 961
G P T Y + +N N AT+ +DI+ S Y +
Sbjct: 7995 YKGDTKLRPTTTYKMHFRN------------------NVATLVFNQVDINDSGEYICK-- 8034
Query: 962 AKNRIGKSEPSNELTITADEAAPD------------GPPQEVHLEPISSQSIRVTWKAPK 1009
A+N +G+ S LT+ + P G P S+ I V+W
Sbjct: 8035 AENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDG 8094
Query: 1010 KHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNR 1069
K L++ N Q + + D + ++ D + QY A N
Sbjct: 8095 KPLKD---------------SPNVQTSFL--DNTATLNIFKTDR-SLAGQYSCT--ATNP 8134
Query: 1070 AGTGPSSQEIITTTLEDVPSY-----PPENV-------QAIATSPESISISWSTLSKEAL 1117
G+ SS +I T ++ P + P + V + T + I +SW+ S+E
Sbjct: 8135 IGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIR 8194
Query: 1118 NGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLA--FTRAGDGV 1175
+G +++ Y N + T ++ +YT Y++ + A +
Sbjct: 8195 SG--GKYQISYLEN----------SAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNI 8242
Query: 1176 RSEQI---FTR----TKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSH 1228
+ I FT+ T E+ G ++ A + + V+W K N I+
Sbjct: 8243 KERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAW---YKNNIEIQ-------- 8291
Query: 1229 PYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRG-NSSEIITVEPLAKAPAR 1287
PT E ++ ++ N AG +S I+ EP K P
Sbjct: 8292 --PTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEP--KKPPV 8347
Query: 1288 ILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI-- 1345
VT + + L C G ++W+K + D F++G+ +
Sbjct: 8348 FDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGR---EIKPSDRCSFSFASGTAVLE 8404
Query: 1346 IRTVKAEDSGYYSCIANNNWGSD 1368
+R V DSG Y C A+N GSD
Sbjct: 8405 LRDVAKADSGDYVCKASNVAGSD 8427
Score = 240 bits (613), Expect = 9e-63
Identities = 352/1515 (23%), Positives = 594/1515 (39%), Gaps = 193/1515 (12%)
Query: 50 GIPPVTLRWYLATGEEIY-DVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPS 108
G PP + W+ E + D I L++F S Y C N +
Sbjct: 5918 GTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQ------SGEYTCVVSNNA 5971
Query: 109 GKIRSQDVHIKAVLREP--YTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVS 166
G+ + ++EP + R+ D G + + ++ +T W+KD +
Sbjct: 5972 GQASCTT---RLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVT---WKKDGFN 6025
Query: 167 LVSGSRFLITSTGALYIKDVQNED--GLYNYRCITRHRYTGETRQSNSARLFVSDPANSA 224
+ + + I +T I ++ N Y C + R A + +P
Sbjct: 6026 ITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENE---AGRDVCGALVSTLEP---- 6078
Query: 225 PSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL----ELSGRFQKTVTGLLI 280
P + + +A G V L C+ G PE W K + L E F V L+
Sbjct: 6079 PYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVF 6138
Query: 281 ENIRPSDSGSYVCEVSNRYGTA--KVIGRLYVKQ-PLKATISPRKVKSSVGSQVSLSCSV 337
+ +DSG Y C+ N GTA K + R+ +Q P + ++ +VG V+L+C +
Sbjct: 6139 NKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRL 6198
Query: 338 TGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSD---GGAYQCFVRKDKLSA 394
G+ ++ WYR+G +L +N++ + + +N+ ++++D G Y C +A
Sbjct: 6199 NGSAPIQVCWYRDGVLLRDDENLQTSFV--DNVATLKILQTDLSHSGQYSCSASNPLGTA 6256
Query: 395 QDYVQVVLEDGTPKIISAFSEKVVS----PAEPVSLMCNVKGTPLPTITWTLDDDPILKG 450
++ + PK F K VS E C+V G ITW+ D+ I G
Sbjct: 6257 SSSARLTARE--PKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPG 6314
Query: 451 GSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPM 510
G++ I T GN +L I D G Y C A N G + A+++V+ P
Sbjct: 6315 GNYTI----TCVGNT-PHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPPKFVKK 6369
Query: 511 KNITAIA--GRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR-QVAFENNGTLKLSDVQKE 567
+ +A G + C++ G P + W++N + L + + ++F N+ L +
Sbjct: 6370 LEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASA 6429
Query: 568 VDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSI-GQRVFIPCVVVSGDLPI 626
D G+Y C S S +TVK PP P ++ G V + C + SG P
Sbjct: 6430 EDSGDYICEAH-NGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEI-SGTPPF 6487
Query: 627 TITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV 686
+ W KD + + S I + F +SL I NL G Y C A NE + +
Sbjct: 6488 EVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKF 6547
Query: 687 RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL 746
+ PP+FV + D + G AV L EG+ ++VW +G + + + N RI +
Sbjct: 6548 KEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESE----NTRISFI 6603
Query: 747 SN-GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKK 805
N +L + +SG Y+C++ ND G S LTV PA I P T G
Sbjct: 6604 DNIATLQLGSPEASNSGKYICQIKNDAGMR-ECSAVLTVLEPARIIEKPEPMTVTTGNPF 6662
Query: 806 EMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSC 865
+ C G + +W K+ R ++ + ++ +V ++L+I D G +S
Sbjct: 6663 ALECVVTGTPELSAKWFKDGRELSADSKHHITFINKV-----ASLKIPCAEMSDKGLYSF 6717
Query: 866 HAINSYGEDRGIIQLTVQEPPDPPEI--EIKDVKA---RTITLRWTMGFDGNSPITGYDI 920
NS G+ + + V + PP ++KDV A ++ L + G++PI+
Sbjct: 6718 EVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRV--SGSAPISVGWF 6775
Query: 921 ECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITAD 980
+ N+ S Q S + + + + PS T A N G E S LT+
Sbjct: 6776 QDGNEIVSGPKCQ--SSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEP 6833
Query: 981 EAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRG-------YQIGYREYSTGGNF 1033
+ P +E + S+ T +IRG + G RE G +
Sbjct: 6834 PSFEQTPDS---VEVLPGMSLTFT----------SVIRGTPPFKVKWFKGSRELVPGES- 6879
Query: 1034 QFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEI-------ITTTLED 1086
NI D + E++ + L LV N AG+ + + L D
Sbjct: 6880 -CNISLEDFVTELELFEVQPLESGDYSCLVT---NDAGSASCTTHLFVKEPATFVKRLAD 6935
Query: 1087 --VPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNIT 1144
V + P ++A T IS+SW + E L I Q R +IT
Sbjct: 6936 FSVETGSPIVLEATYTGTPPISVSW--IKDEYL--ISQSERC---------------SIT 6976
Query: 1145 TTQPSLELDGLEK----YTNYSIQVLAFTRAGDGVRSEQIFT----------RTKEDVPG 1190
T+ S L+ LE Y YS L AG + + E V G
Sbjct: 6977 MTEKSTILEILESTIEDYAQYS--CLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIG 7034
Query: 1191 PPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPN 1250
PA ++ + +SW +++T S P +F+ + S +
Sbjct: 7035 EPATLQCKVDGTPEIRISW---------YKEHTKLRS--APAYKMQFKNNVASLVINKVD 7083
Query: 1251 LSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAP---ARILTFSGTVTTPWMKDIVLPC 1307
S +YS A S G SS ++ ++ P ++ T+ P + C
Sbjct: 7084 HSDVGEYS--CKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFP----VAFEC 7137
Query: 1308 KAVGDPSPAVKWMKDSNGTPSLVTIDGR-RSIFSNGSFIIRTVKAEDS--GYYSCIANNN 1364
+ G V W KD L+ D ++ F + ++ ++ + S G Y+C A+N
Sbjct: 7138 RINGSEPLQVSWYKDG----VLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNP 7193
Query: 1365 WG----SDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDN 1420
G S ++IL+ + +VPP VS + + ++ G + I+ + +++DN
Sbjct: 7194 LGTASSSAKLILS-EHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIK---ITWAKDN 7249
Query: 1421 SE--QWGSFPISPSERSYRLENLKCG-------TWY------KFTLTAQNGV-GPGRISE 1464
E G++ ++ E + L LK G T Y K + +AQ GV P R +
Sbjct: 7250 REIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIK 7309
Query: 1465 IIEAKTLGKEPQFSK 1479
+E + K+ +F++
Sbjct: 7310 KLEPSRIVKQDEFTR 7324
Score = 222 bits (566), Expect = 3e-57
Identities = 260/1007 (25%), Positives = 393/1007 (39%), Gaps = 92/1007 (9%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAE 105
C AG P++++W+ E H N F S TY C+A
Sbjct: 4696 CIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTA-----FLEISQLEGTDSGTYTCSAT 4750
Query: 106 NPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAV-FKCIIPSSVEAYITVVSWEKDT 164
N +G + H+ V PY V + + N V K ++ + + W KD
Sbjct: 4751 NKAGHNQCSG-HL-TVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPM---TIKWFKDN 4805
Query: 165 VSLVSGSRFLI----TSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDP 220
L SG+ + TST + G Y C + T + A LFV +P
Sbjct: 4806 KELHSGAARSVWKDDTSTSLELFAAKATDSG--TYICQLSNDVGTAT---SKATLFVKEP 4860
Query: 221 ANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGR----FQKTVT 276
R GQ C+ G P+ W D + + F +
Sbjct: 4861 PQFIKKPSPVLVLRN---GQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLA 4917
Query: 277 GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCS 336
I R +SG+YVCE N GTA L VK+P + V+ S V L C
Sbjct: 4918 TFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECE 4977
Query: 337 VTGTEDQELSWYRNGEILNPGKNVRITG-INHENLIMDHMVKSDGGAYQCFVRKDKLSAQ 395
VTGT E++W +N + K +T ++ NL + SD G YQC V + S
Sbjct: 4978 VTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCS 5037
Query: 396 DYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRI 455
+V L++ P I + V G+P +ITW L DD IL +
Sbjct: 5038 CSTRVALKE-PPSFIKKIENTTTVLKSSATFQSTVAGSPPISITW-LKDDQILDEDDNVY 5095
Query: 456 SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITA 515
+ S V+ L I S G Y C A N +GV A + V+ PA I
Sbjct: 5096 ISFVDS----VATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVD 5151
Query: 516 IAGRDTY-IHCRVIGYPYYSIKWYKNSN-LLPFNHRQVAFENN-GTLKLSDVQKEVDEGE 572
+ +D + C V G P +KW K+ ++P + ++FENN + ++ V K+ D G+
Sbjct: 5152 VTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQ-DSGQ 5210
Query: 573 YTCNVLVQPQLSTSQSVHVTV---KVPP-FIQPFEFPRFSIGQRVFIPCVVVSGDLPITI 628
YT V S+S ++ V +PP F + +G + + C V SG LPI+
Sbjct: 5211 YTFKV-ENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKV-SGSLPISA 5268
Query: 629 TWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRV 688
W KDG+ I S + + + SL ++NL L NYTC N A L V+
Sbjct: 5269 QWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKE 5328
Query: 689 PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVW---KFSKGAGVPQFQPIALNGRIQV 745
PP F+V+P Q I V +G P I W +G F I L G
Sbjct: 5329 PPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCF--IGLEG---- 5382
Query: 746 LSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKK 805
S L + V +G Y C V+NDVG+D +M L + P + + + G
Sbjct: 5383 -STSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSS 5441
Query: 806 EMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSC 865
+ C G I V W + + + P +Y ++ + ++ +Q+ EDSG F C
Sbjct: 5442 RLECKIAGSPEIRVVWFRNEHEL-PASDKYRMTF----IDSVAVIQMNNLSTEDSGDFIC 5496
Query: 866 HAINSYGEDRGIIQLTVQEPP----DPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIE 921
A N G ++ V+EPP PP +E +K ++L + G P +++
Sbjct: 5497 EAQNPAGSTSCSTKVIVKEPPVFSSFPPIVE--TLKNAEVSLECEL--SGTPP---FEVV 5549
Query: 922 CKNKSDSWDSAQRTKDVSPQLN-SATIIDIHPSSTYSIRMYAKNRIGK---------SEP 971
S+++ K S + S I+++ S A+N +G EP
Sbjct: 5550 WYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEP 5609
Query: 972 S------NELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHL 1012
N LT+ A G P E+ +Q I V W K+ +
Sbjct: 5610 PRFVSKLNSLTVVA------GEPAELQASIEGAQPIFVQWLKEKEEV 5650
Score = 215 bits (548), Expect = 3e-55
Identities = 214/827 (25%), Positives = 348/827 (42%), Gaps = 80/827 (9%)
Query: 93 TLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVR-VEDQKTMRGNVAVFKCIIPSSV 151
T+ Y C A N G Q I ++ +P+ ++ +E ++ +C +
Sbjct: 3614 TIQDRGVYSCKASNKFGADICQAELI--IIDKPHFIKELEPVQSAINKKVHLECQVDEDR 3671
Query: 152 EAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQ----NEDGLYNYRCITRHRYTGET 207
+ +T W KD L G + I + ++ + G Y T G +
Sbjct: 3672 KVTVT---WSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTY---VCTASNEAGSS 3725
Query: 208 RQSNSARLFVSDPANSAPSILDGFDHRKAMA-GQRVELPCKALGHPEPDYRWLKDNMPLE 266
S SA + V +P PS + D M G+ L CK G P W K+N L
Sbjct: 3726 --SCSATVTVREP----PSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELS 3779
Query: 267 LSGR----FQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLK--ATISP 320
S F + L I +++ DSGSY CE N G+ + +K+P T+ P
Sbjct: 3780 ESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEP 3839
Query: 321 RKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVK--- 377
+ G+ L C V+GT E+SW+++ + + K R+ + ++L+ +
Sbjct: 3840 ADIVR--GTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRL--FSQKSLVCLEIFSFNS 3895
Query: 378 SDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPT 437
+D G Y+C V + +L++ P + + + + V+L V+G+ +
Sbjct: 3896 ADVGEYECVVANEVGKCGCMATHLLKE-PPTFVKKVDDLIALGGQTVTLQAAVRGSEPIS 3954
Query: 438 ITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQA 497
+TW + I + G ++S N V+ L I Q+ GG Y C A N AG
Sbjct: 3955 VTWMKGQEVIREDGKIKMSF-----SNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVG 4009
Query: 498 RINVRGPASIRPMKNITAI-AGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR-QVAFEN 555
+ V+ PA I + + AG + V G P KWYK+ L + + +++F+N
Sbjct: 4010 ELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKN 4069
Query: 556 N-GTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVK---VPPFIQPFEFPRFSIGQ 611
N LK + D G+YT + + S+ ++ + P F +P +
Sbjct: 4070 NVAQLKFYSAELH-DSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVNG 4128
Query: 612 RVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIA 671
+ C + +G LP+ ++W KDG+ I S I ++ T+SL I + + GN+TC A
Sbjct: 4129 TCRLDCKI-AGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRA 4187
Query: 672 RNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGV 731
N + + LIV+ PP FV +P +D + G AV L + +G TI W
Sbjct: 4188 TNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRW-------- 4239
Query: 732 PQFQPIALNGRIQVLSNGSLLI-KHVVE----------EDSGYYLCKVSNDVGADVSKSM 780
G +++S GS I K +E DSG Y CKVSN V V S
Sbjct: 4240 -------FKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSN-VAGGVECSA 4291
Query: 781 YLTVKIPA-MITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVST 839
L VK PA + + L +G +++C G PI + W DR I E +++ +S
Sbjct: 4292 NLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFANDREIK-ESSKHRMSF 4350
Query: 840 KEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886
E + L++ EDSG + C A N G D + V+E P
Sbjct: 4351 ----VESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESP 4393
Score = 209 bits (533), Expect = 2e-53
Identities = 320/1396 (22%), Positives = 536/1396 (38%), Gaps = 155/1396 (11%)
Query: 43 LVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNG----TLQIFPFPPSSFSTLIHDN 98
++ C AG P+++ W+ E+ V G ++ TLQ+ S
Sbjct: 5818 ILECKVAGSSPISVAWF---HEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGN----- 5869
Query: 99 TYYCTAENPSGKIRSQDVHIKAVLREP--YTVRVEDQKTMRGNVAVFKCIIPSSVEAYIT 156
Y C A N +G S + ++EP + E + + G F +I +
Sbjct: 5870 -YTCVAANVAG---SDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFK-- 5923
Query: 157 VVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYT-----GETRQSN 211
V+W + LV G R I Y +D E L+N YT + S
Sbjct: 5924 -VNWFRGARELVKGDRCNI------YFEDTVAELELFNIDISQSGEYTCVVSNNAGQASC 5976
Query: 212 SARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRF 271
+ RLFV +PA + L G+ + L G W KD + S +
Sbjct: 5977 TTRLFVKEPA----AFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKC 6032
Query: 272 QKTVTG----LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSV 327
T L I N D+G Y CE+ N G + +P ++++V
Sbjct: 6033 NIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAV 6092
Query: 328 GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINH-ENLIMDHMVKSDGGAYQCF 386
G VSL C V GT + +SWY+ L P R N+ L+ + + +D G Y C
Sbjct: 6093 GDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCK 6152
Query: 387 VRKD--KLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDD 444
S++ ++ P + + PV+L C + G+ + W D
Sbjct: 6153 AENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCW-YRD 6211
Query: 445 DPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGP 504
+L+ + + TS + V+ L I + + G Y C+A+N G AR+ R P
Sbjct: 6212 GVLLRDDEN----LQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREP 6267
Query: 505 AS-----IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK-NSNLLPF-NHRQVAFENNG 557
I+P+ +I IAG C V G I W K N + P N+ N
Sbjct: 6268 KKSPFFDIKPV-SIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTP 6326
Query: 558 TLKLSDVQKEVDEGEYTCNVL--VQPQLSTSQSVHVTVKVPP-FIQPFEFPRFSI-GQRV 613
L++ V K D G+YTC V + ++Q ++VK PP F++ E + + G+ +
Sbjct: 6327 HLRILKVGKG-DSGQYTCQATNDVGKDMCSAQ---LSVKEPPKFVKKLEASKVAKQGESI 6382
Query: 614 FIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARN 673
+ C + SG I ++W ++ + S + I+ + L I+ S +G+Y C A N
Sbjct: 6383 QLECKI-SGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHN 6441
Query: 674 EAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQ 733
+ L V+ PP F +P + G VIL C G P +VW V
Sbjct: 6442 GVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVW-------VKD 6494
Query: 734 FQPIALNGRIQVLS---NGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMI 790
+ + + + ++ S + SL I ++ D G Y CK +N+VG+D S + K P
Sbjct: 6495 RKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTC-SCSVKFKEPPRF 6553
Query: 791 TSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTL 850
+ T G E+ G +PI V W K+ E+ R +T+ + I+TL
Sbjct: 6554 VKKLSDTSTLIGDAVELRAIVEGFQPISVVWLKD----RGEVIRESENTRISFIDNIATL 6609
Query: 851 QILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFD 910
Q+ +SG + C N G LTV EP E K +T+ F
Sbjct: 6610 QLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIE------KPEPMTVTTGNPFA 6663
Query: 911 GNSPITGY-DIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYA---KNRI 966
+TG ++ K D + + +K +N + I + +Y+ KN +
Sbjct: 6664 LECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSV 6723
Query: 967 GKSEPSNELTITADEAAPDGPPQEVHLEPISSQSI----RVTWKAPKKHLQNGIIRGYQI 1022
GKS + + ++ P + + I S+ RV+ AP I G+
Sbjct: 6724 GKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAP-------ISVGWFQ 6776
Query: 1023 GYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITT 1082
E +G Q +S V TL NL+ + C A S +
Sbjct: 6777 DGNEIVSGPKCQ-------SSFSENVCTL-NLSLLEPSDTGIYTCVAANVAGSDECSAVL 6828
Query: 1083 TLEDVPSYP--PENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEI 1140
T+++ PS+ P++V+ + +S++++++ + F+V ++ + GE
Sbjct: 6829 TVQEPPSFEQTPDSVEVLP----GMSLTFTSVIRGT-----PPFKVKWFKGSRELVPGES 6879
Query: 1141 KNITTTQ--PSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAA 1198
NI+ LEL ++ + L AG + +F + A
Sbjct: 6880 CNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVKRLADFSVE 6939
Query: 1199 AASASMVFVSWL--PPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQ 1256
S ++ ++ PP+ ++ I +Y + S ++E + I + + Q
Sbjct: 6940 TGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYA---Q 6996
Query: 1257 YSVWVVAVTSAGRGNSSEIITV-------EPLAKAPARILTFSGTVTTPWMKDIVLPCKA 1309
YS + AG+ +++V EPL A I G T L CK
Sbjct: 6997 YSCLIE--NEAGQDICEALVSVLEPPYFIEPLEHVEAVI----GEPAT-------LQCKV 7043
Query: 1310 VGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNG--SFIIRTVKAEDSGYYSCIANNNWG- 1366
G P + W K+ L + + F N S +I V D G YSC A+N+ G
Sbjct: 7044 DGTPEIRISWYKEHT---KLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGA 7100
Query: 1367 --SDEIILNLQVQVPP 1380
S +++ ++PP
Sbjct: 7101 VASSAVLVIKARKLPP 7116
Score = 207 bits (526), Expect = 1e-52
Identities = 303/1401 (21%), Positives = 522/1401 (37%), Gaps = 170/1401 (12%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAE 105
C AG P + + W+ +++P + ++ ST + C A+
Sbjct: 5445 CKIAGSPEIRVVWF----RNEHELPASDKYRMTFIDSVAVIQMNNLSTE-DSGDFICEAQ 5499
Query: 106 NPSGKIRSQDVHIKAVLREP--YTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKD 163
NP+G S K +++EP ++ +T++ +C + + + W KD
Sbjct: 5500 NPAG---STSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVV---WYKD 5553
Query: 164 TVSLVSGSRFLITSTG---ALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDP 220
L S ++ I S +++I +V D + Y C ++ +T +
Sbjct: 5554 KRQLRSSKKYKIASKNFHTSIHILNVDTSD-IGEYHCKAQNEVGSDT-------CVCTVK 5605
Query: 221 ANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL-----ELSGRFQKTV 275
P + + +AG+ EL G +WLK+ + + F + V
Sbjct: 5606 LKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENV 5665
Query: 276 TGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSC 335
L P+++G Y+C++ N G + + L V +P + +VG +L C
Sbjct: 5666 ATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLEC 5725
Query: 336 SVTGTEDQELSWYRNGEILNPGKNVRITGINH-ENLIMDHMVKSDGGAYQCFVRKD--KL 392
V GT + + WY++G++L + + + N +L + + + D G Y V+ + K
Sbjct: 5726 KVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKS 5785
Query: 393 SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 452
S V V P L C V G+ ++ W + I+ G
Sbjct: 5786 SCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAK 5845
Query: 453 HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS-IRPMK 511
++ T+ + V L ++S D G Y C A N AG +A + V+ P S ++ +
Sbjct: 5846 YQ-----TTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPE 5900
Query: 512 NITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR-QVAFENN-GTLKLSDVQKEVD 569
+ + G++ + G P + + W++ + L R + FE+ L+L ++
Sbjct: 5901 PLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDIS-Q 5959
Query: 570 EGEYTCNVLVQPQLSTSQSVHVTVKVP-PFIQPFEFPRFSIGQRVFIPCVVVSGDLPITI 628
GEYTC V+ S + + VK P F++ G+ + + +G LPI++
Sbjct: 5960 SGEYTC-VVSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILES-TYTGTLPISV 6017
Query: 629 TWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRV 688
TW+KDG I S I + T L I N + G Y+C NEA + +
Sbjct: 6018 TWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLE 6077
Query: 689 PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVW--KFSKGAGVPQFQPIALNGRIQVL 746
PP FV + + G +V L C G P T+ W +K P+++ N
Sbjct: 6078 PPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTN------ 6131
Query: 747 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV--KIPAMITSYPNTTLATQGQK 804
+ +L+ V DSG Y CK N +G SK+++ ++P T G
Sbjct: 6132 NVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLP 6191
Query: 805 KEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFS 864
++C +G PI V W ++ ++ + + T V + ++TL+IL T SG +S
Sbjct: 6192 VTLTCRLNGSAPIQVCWYRDGVLLRDDEN---LQTSFV--DNVATLKILQTDLSHSGQYS 6246
Query: 865 CHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVK-----------------ARTITLRWTM 907
C A N G +LT +EP P +IK V A+ + + W+
Sbjct: 6247 CSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHVTGAQPMRITWSK 6306
Query: 908 GFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIG 967
P Y I C +P L I+ + + A N +G
Sbjct: 6307 DNKEIRPGGNYTITCVGN-------------TPHLR---ILKVGKGDSGQYTCQATNDVG 6350
Query: 968 KSEPSNELTI----------TADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGII 1017
K S +L++ A + A G ++ + S I+V+W L
Sbjct: 6351 KDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELH---- 6406
Query: 1018 RGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ 1077
++ ++ N S + SGD + +A N G S
Sbjct: 6407 ESWKYNMSFINSVALLTINEASAEDSGD----------------YICEAHNGVGDA-SCS 6449
Query: 1078 EIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGEL 1137
+T V + P V A+ S + S F V++ +
Sbjct: 6450 TALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPP---------FEVVWVKDRKQVRN 6500
Query: 1138 GEIKNITTT--QPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGV 1195
+ IT+ SL + LE A G S + + KE PP V
Sbjct: 6501 SKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSV--KFKE----PPRFV 6554
Query: 1196 KAAAASASMVFVSWLPPLKLNGIIRKY---TVFCSHPYPTVISEFEASPDSFSYRI---- 1248
K + +++++ ++L I+ + +V VI E E + SF I
Sbjct: 6555 KKLSDTSTLIG----DAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQ 6610
Query: 1249 ---PNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVL 1305
P S + +Y + AG S ++TV PARI+ +T L
Sbjct: 6611 LGSPEASNSGKYICQI--KNDAGMRECSAVLTV----LEPARIIEKPEPMTVTTGNPFAL 6664
Query: 1306 PCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSI-FSN--GSFIIRTVKAEDSGYYSCIAN 1362
C G P + KW KD ++ D + I F N S I + D G YS
Sbjct: 6665 ECVVTGTPELSAKWFKDGRE----LSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVK 6720
Query: 1363 NNWGSDEIILNLQVQ---VPP 1380
N+ G +++ V VPP
Sbjct: 6721 NSVGKSNCTVSVHVSDRIVPP 6741
Score = 206 bits (523), Expect = 2e-52
Identities = 218/887 (24%), Positives = 362/887 (40%), Gaps = 84/887 (9%)
Query: 39 TTGTL--VPCPAAGIPPVTLRWYL----ATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFS 92
TTG + C AG P ++ +W+ T + Y + V L+I PS
Sbjct: 7598 TTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKV---SGLKIINVAPSD-- 7652
Query: 93 TLIHDNTYYCTAENPSGK---IRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPS 149
Y +NP GK S V + V +T ++++ + G+ V +C +
Sbjct: 7653 ----SGVYSFEVQNPVGKDSCTASLQVSDRTV-PPSFTRKLKETNGLSGSSVVMECKVYG 7707
Query: 150 SVEAYITVVSWEKDTVSLVSGSRFLIT---STGALYIKDVQNEDGLYNYRCITRHRYTGE 206
S VSW + + SG ++ T +T AL + ++ D +Y CI + +
Sbjct: 7708 SPPIS---VSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDS-GDYTCIATNMAGSD 7763
Query: 207 TRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
SA L V +P PS + D + G V G P W K + L
Sbjct: 7764 ---ECSAPLTVREP----PSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELV 7816
Query: 267 LSGR----FQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRK 322
R + +V L + ++ S SG Y C VSN G A LY+K P K
Sbjct: 7817 PGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLND 7876
Query: 323 VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLI-MDHMVKSDGG 381
G + L + TGT ++W +NG + P + IT ++ + D G
Sbjct: 7877 YSIEKGKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAG 7936
Query: 382 AYQCFVR----KDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPT 437
Y C++ KD SAQ ++LE P + VS + SL C + GTP
Sbjct: 7937 QYNCYIENASGKDSCSAQI---LILEP--PYFVKQLEPVKVSVGDSASLQCQLAGTPEIG 7991
Query: 438 ITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQA 497
++W D + ++++ N V+ L + + D G Y C A NS G V
Sbjct: 7992 VSWYKGDTKLRPTTTYKMHFR-----NNVATLVFNQVDINDSGEYICKAENSVGEVSAST 8046
Query: 498 RINVRG----PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR-QVA 552
+ V+ P+ R ++++ G C + G S+ WYK+ L + Q +
Sbjct: 8047 FLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTS 8106
Query: 553 F-ENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTV---KVPPFIQPFEFPRFS 608
F +N TL + + + G+Y+C P S S S + + K PPF P +
Sbjct: 8107 FLDNTATLNIFKTDRSL-AGQYSCTA-TNPIGSASSSARLILTEGKNPPFFDIRLAPVDA 8164
Query: 609 I-GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNY 667
+ G+ C V +G PI ++W KD R I I ++ ++ L + + +G Y
Sbjct: 8165 VVGESADFECHV-TGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQY 8223
Query: 668 TCIARNEAAAVEHQSQLIVR---VPPKFVVQPRDQ-DGIYGKAVILNCSAEGYPVPTIVW 723
TC A NE +QL ++ +PP F + + + G + L G T+ W
Sbjct: 8224 TCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAW 8283
Query: 724 KFSKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMYL 782
+ + QP + N I +N +L ++ D+G Y CKVSND G+ + S +
Sbjct: 8284 YKNN----IEIQPTS-NCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIV 8338
Query: 783 --TVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINP-EMARYLVST 839
K P + + ++G+ ++SC G +PI ++W K R I P + + ++
Sbjct: 8339 IKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFAS 8398
Query: 840 KEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886
+ L++ + DSG + C A N G D ++T+++ P
Sbjct: 8399 G------TAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKP 8439
Score = 202 bits (515), Expect = 2e-51
Identities = 319/1435 (22%), Positives = 548/1435 (38%), Gaps = 163/1435 (11%)
Query: 39 TTGT--LVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIH 96
TTG + C G P ++ +W+ G E+ H+ + P + S
Sbjct: 6657 TTGNPFALECVVTGTPELSAKWF-KDGREL-SADSKHHITFINKVASLKIPCAEMSD--- 6711
Query: 97 DNTYYCTAENPSGKIR-SQDVHIKAVLREPYTVR-VEDQKTMRGNVAVFKCIIPSSVEAY 154
Y +N GK + VH+ + P +R ++D + G V +C + S
Sbjct: 6712 KGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPIS 6771
Query: 155 ITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQ----NEDGLYNYRCITRHRYTGETRQS 210
V W +D +VSG + + + + ++ ++ G+Y C+ + +
Sbjct: 6772 ---VGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYT--CVAANVAGSD---E 6823
Query: 211 NSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL----E 266
SA L V +P PS D + + G + G P +W K + L
Sbjct: 6824 CSAVLTVQEP----PSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGES 6879
Query: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSS 326
+ + VT L + ++P +SG Y C V+N G+A L+VK+P AT R S
Sbjct: 6880 CNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEP--ATFVKRLADFS 6937
Query: 327 V--GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKS--DGGA 382
V GS + L + TGT +SW ++ +++ + IT + ++ I++ + + D
Sbjct: 6938 VETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSIT-MTEKSTILEILESTIEDYAQ 6996
Query: 383 YQCFVRKDKLSAQDYVQV---VLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTIT 439
Y C + + + QD + VLE P I EP +L C V GTP I+
Sbjct: 6997 YSCLIENE--AGQDICEALVSVLEP--PYFIEPLEHVEAVIGEPATLQCKVDGTPEIRIS 7052
Query: 440 WTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARI 499
W + + ++++ N V+ L I+ D G Y C A+NS G V A +
Sbjct: 7053 WYKEHTKLRSAPAYKMQFK-----NNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVL 7107
Query: 500 NVRG----PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFN-HRQVAFE 554
++ P R +K++ G CR+ G + WYK+ LL + + Q +F
Sbjct: 7108 VIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFV 7167
Query: 555 NN-GTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTV---KVPPF--IQPFEFPRFS 608
+N TL++ + G+Y C+ P + S S + + +VPPF ++P +
Sbjct: 7168 HNVATLQILQTDQS-HIGQYNCSAS-NPLGTASSSAKLILSEHEVPPFFDLKPVSVD-LA 7224
Query: 609 IGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYT 668
+G+ C V +G PI ITW KD R I + ++ T++L + + G YT
Sbjct: 7225 LGESGTFKCHV-TGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYT 7283
Query: 669 CIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGI-YGKAVILNCSAEGYPVPTIVWKFSK 727
C A N A +QL V+ PP+F+ + + + C G P ++W +
Sbjct: 7284 CYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLW-YKD 7342
Query: 728 GAGVPQFQPIALNGRIQVLSNGSLLIKHVVE-EDSGYYLCKVSNDVGADVSKSMYLTVKI 786
+ + R+ + + ++L H + EDSG Y C+ N G+ S S L VK
Sbjct: 7343 ETEIQESSKF----RMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGS-ASSSTSLKVKE 7397
Query: 787 PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEV 846
P + P+ +G + C G P V W K+ R + ++S E
Sbjct: 7398 PPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMS-----ENF 7452
Query: 847 ISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPE--IEIKDVKARTITLR 904
++++ IL D G + C A N G D + + ++ PP + +I V + + L+
Sbjct: 7453 LTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQ 7512
Query: 905 WTMGFDGNSPITGYDIECKNK----SDS-WDSAQRTKDVSPQLNSATIIDIHPSSTYSIR 959
T+ +G PI+ + K + SD+ W S S + + + P++
Sbjct: 7513 TTI--EGAEPISVVWFKDKGEIVRESDNIWIS------YSENIATLQFSRVEPANAGKYT 7564
Query: 960 MYAKNRIGKSEPSNELTITADEAAPDGPPQ---------EVHLEPISSQSIRVTWKAPKK 1010
KN G E L++ + P + + + W K
Sbjct: 7565 CQIKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGK 7624
Query: 1011 HLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRA 1070
L + Y+I + +G II+V S DS VY+ + N +
Sbjct: 7625 ELTSD--NKYKISFFNKVSG----LKIINVAPS-DSGVYSFEVQNPVGKDSCTASLQVSD 7677
Query: 1071 GTGPSSQEIITTTLEDVPSYPPENV--QAIATSPESISISWSTLSKEALNGILQGFRVIY 1128
T P S T L++ +V + IS+SW E +G Y
Sbjct: 7678 RTVPPS---FTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRK------Y 7728
Query: 1129 WANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKED- 1187
L D +L ++ LE+ + +A AG S + R
Sbjct: 7729 QTTLTDNTC-----------ALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSF 7777
Query: 1188 VPGP-PAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSY 1246
V P P V V PP ++ + + + A + F
Sbjct: 7778 VQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDV 7837
Query: 1247 RIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLP 1306
+ S++ +Y+ + AG+ + + + + KAPA+ + + K ++L
Sbjct: 7838 ---DTSQSGEYTC--IVSNEAGKASCTTHLYI----KAPAKFVKRLNDYSIEKGKPLILE 7888
Query: 1307 CKAVGDPSPAVKWMKDS-NGTPSL---VTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
G P +V W K+ N TPS +T + +I I + ED+G Y+C
Sbjct: 7889 GTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILE-----IPSSTVEDAGQYNCYIE 7943
Query: 1363 NNWGSDEIILNLQVQVPP--------------DQPRLTVSKTTSSSITLSWLPGD 1403
N G D + + PP D L + I +SW GD
Sbjct: 7944 NASGKDSCSAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGD 7998
Score = 200 bits (509), Expect = 1e-50
Identities = 213/983 (21%), Positives = 402/983 (40%), Gaps = 70/983 (7%)
Query: 26 FVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVP--GIRHVHPNGTLQI 83
F+ +V + T C G P + + WYL G EI + GI + T QI
Sbjct: 4863 FIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYL-DGNEITAIQKHGISFIDGLATFQI 4921
Query: 84 FPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTV--RVEDQKTMRGNVA 141
S + + + TY C A N +G + I+ ++EP T ++ + ++ +
Sbjct: 4922 ------SGARVENSGTYVCEARNDAG---TASCSIELKVKEPPTFIRELKPVEVVKYSDV 4972
Query: 142 VFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNED--GLYNYRCIT 199
+C + + +T W K+ + S ++ +T +++ + D Y+CI
Sbjct: 4973 ELECEVTGTPPFEVT---WLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIV 5029
Query: 200 RHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWL 259
+ S S R+ + +P PS + ++ + G P WL
Sbjct: 5030 SNE---GGSCSCSTRVALKEP----PSFIKKIENTTTVLKSSATFQSTVAGSPPISITWL 5082
Query: 260 KDNMPLELSGR----FQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLK 315
KD+ L+ F +V L I ++ SG Y C+ N G + L V++P +
Sbjct: 5083 KDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQ 5142
Query: 316 ATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINH-ENLIMDH 374
+ V + ++L C V GT + ++ W ++G+ + P + ++ N+ + +
Sbjct: 5143 IVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQS 5202
Query: 375 MVKSDGGAYQCFVRKD--KLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKG 432
++K D G Y V D S Y++V+ ++ P ++ + + C V G
Sbjct: 5203 VMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSG 5262
Query: 433 TPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV 492
+ + W D I +R ++ E +V L +++ ++ D Y C +N AG
Sbjct: 5263 SLPISAQWFKDGKEISTSAKYR---LVCHERSV--SLEVNNLELEDTANYTCKVSNVAGD 5317
Query: 493 VLYQARINVRGPAS--IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQ 550
+ V+ P S ++P + AI + G P + IKW+K+ L +
Sbjct: 5318 DACSGILTVKEPPSFLVKPGRQ-QAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKC 5376
Query: 551 VAFENNGTLKLSDVQKEVDE-GEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRF-S 608
T L+ + + G+YTC+V + ++ + + P F++ E +
Sbjct: 5377 FIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVK 5436
Query: 609 IGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYT 668
G + C ++G I + W ++ +P S + ID + ++++NLS +G++
Sbjct: 5437 AGDSSRLEC-KIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFI 5495
Query: 669 CIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKG 728
C A+N A + +++IV+ PP F P + + V L C G P +VW K
Sbjct: 5496 CEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDK- 5554
Query: 729 AGVPQFQPIALNGRIQVLSNG---SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVK 785
+ + + + ++ S S+ I +V D G Y CK N+VG+D + TVK
Sbjct: 5555 ------RQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSD---TCVCTVK 5605
Query: 786 I--PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVG 843
+ P S N+ G+ E+ + G +PI V+W KE E+ R + +
Sbjct: 5606 LKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKE----KEEVIRESENIRITF 5661
Query: 844 EEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITL 903
E ++TLQ ++G + C N G + L V E P + ++ T+T+
Sbjct: 5662 VENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLE----PAVIVEKAGPMTVTV 5717
Query: 904 RWTMGFDGNSPIT-GYDIECKNKSDSWDSAQRTK-DVSPQLNSATIIDIHPSSTYSIRMY 961
T + T +E S+Q+ K +++S I+ + +
Sbjct: 5718 GETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQ 5777
Query: 962 AKNRIGKSEPSNELTITADEAAP 984
+N +GKS + + + +D A P
Sbjct: 5778 VQNNVGKSSCTAVVDV-SDRAVP 5799
Score = 191 bits (485), Expect = 6e-48
Identities = 221/931 (23%), Positives = 360/931 (38%), Gaps = 83/931 (8%)
Query: 42 TLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDN-TY 100
T + C G PP+ + W+ A EI + R T + I D+ Y
Sbjct: 4317 TQLACKVTGTPPIKITWF-ANDREIKESSKHRMSFVESTAVL-----RLTDVGIEDSGEY 4370
Query: 101 YCTAENPSGKIRSQDVHIKAVLREPY-TVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
C A+N +G + I V PY T + + ++ + + + IT
Sbjct: 4371 MCEAQNEAGSDHCSSIVI--VKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEIT--- 4425
Query: 160 WEKDTVSLVSGSRFLITSTGALY----IKDVQNEDGLYNYRCITRHRYTGETRQSN-SAR 214
W KD L SG ++ L +K V + G Y+C R T E S SAR
Sbjct: 4426 WFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAG--EYQC----RVTNEVGSSICSAR 4479
Query: 215 LFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL----ELSGR 270
+ + +P PS + + ++ G G WLKD+ + +
Sbjct: 4480 VTLREP----PSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMT 4535
Query: 271 FQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQ 330
F+ V L + I G YVC+ N G + L VK+P T + + G
Sbjct: 4536 FENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDP 4595
Query: 331 VSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLI-MDHMVKSDGGAYQCFVRK 389
+L +GT++ W+++G+ L G +I+ + +++ + K D G Y V+
Sbjct: 4596 ATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQN 4655
Query: 390 D--KLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPI 447
D + S + + V+ P + + L C V G+ +I W DD I
Sbjct: 4656 DVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEI 4715
Query: 448 LKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPA-S 506
++ S + ++L IS + D G Y C+A N AG + V+ P
Sbjct: 4716 SASEKYKF-----SFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYF 4770
Query: 507 IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK-NSNLLPFNHRQVAFENNGTLKLSDVQ 565
+ ++ + V G +IKW+K N L R V ++ T
Sbjct: 4771 VEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAA 4830
Query: 566 KEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFI-QPFEFPRFSIGQRVFIPCVVVSGDL 624
K D G Y C + +TS++ + P FI +P GQ C ++G
Sbjct: 4831 KATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFEC-QITGTP 4889
Query: 625 PITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQL 684
I ++W DG I I ID ++ +IS + ++G Y C ARN+A +L
Sbjct: 4890 KIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIEL 4949
Query: 685 IVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQ 744
V+ PP F+ + + + + V L C G P + W + + L R+
Sbjct: 4950 KVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTW-LKNNREIRSSKKYTLTDRVS 5008
Query: 745 VLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQK 804
V +L I D+G Y C VSN+ G+ + + P+ I NTT +
Sbjct: 5009 VF---NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSA 5065
Query: 805 KEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFS 864
S T G PI + W K+D+I++ + Y+ + ++TLQI SG ++
Sbjct: 5066 TFQS-TVAGSPPISITWLKDDQILDEDDNVYISFV-----DSVATLQIRSVDNGHSGRYT 5119
Query: 865 CHAINSYGEDRGIIQLTVQEP--------------PDP----------PEIEI---KDVK 897
C A N G +R L VQEP DP PE+++ KD K
Sbjct: 5120 CQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGK 5179
Query: 898 ARTITLRWTMGFDGNSPITGYDIECKNKSDS 928
+ ++M F+ N + + I+ K DS
Sbjct: 5180 QIVPSRYFSMSFENN--VASFRIQSVMKQDS 5208
Score = 185 bits (470), Expect = 3e-46
Identities = 296/1403 (21%), Positives = 525/1403 (37%), Gaps = 154/1403 (10%)
Query: 55 TLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQ 114
T+R Y E I D+ ++ V +G+ Y C A N G S
Sbjct: 3783 TVRMYFVNSEAILDITDVK-VEDSGS-------------------YSCEAVNDVG---SD 3819
Query: 115 DVHIKAVLREP--YTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSR 172
+ V++EP + +E +RG A+ +C + + I SW KD + S +
Sbjct: 3820 SCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEI---SWFKDKKQIRSSKK 3876
Query: 173 FLITSTGALYIKDVQ--NEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDG 230
+ + S +L ++ N + Y C+ + + + P+ +
Sbjct: 3877 YRLFSQKSLVCLEIFSFNSADVGEYECVVAN-------EVGKCGCMATHLLKEPPTFVKK 3929
Query: 231 FDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGR----FQKTVTGLLIENIRPS 286
D A+ GQ V L G W+K + G+ F V L+I +++ S
Sbjct: 3930 VDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQIS 3989
Query: 287 DSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELS 346
G Y C N G+ +G L VK+P K ++ + G +L +V GT + +
Sbjct: 3990 FGGKYTCLAENEAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPK 4049
Query: 347 WYRNGEILNPGKNVRITGINHENLIMDHMVK-SDGGAYQCFVRKDKLSAQDYVQVVLEDG 405
WY++G L K RI+ N+ + + + D G Y + + S+ + D
Sbjct: 4050 WYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLD- 4108
Query: 406 TPKIISAFSEKVVSPAEPV-----SLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 460
+ I+ F K + + V L C + G+ ++W D I +RI+ +
Sbjct: 4109 --RDIAPFFTKPLRNVDSVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFV-- 4164
Query: 461 SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS-IRPMKNITAIAGR 519
EG + L I + D G + C A NS G + V+ P S + + + G
Sbjct: 4165 -EGT--ASLEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGS 4221
Query: 520 DTYIHCRVIGYPYYSIKWYK-NSNLLPFNHRQVAFEN-NGTLKLSDVQKEVDEGEYTCNV 577
+ G +I+W+K N L+ + E +L+L V K D G YTC V
Sbjct: 4222 AVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLV-KTSDSGTYTCKV 4280
Query: 578 LVQPQLSTSQSVHVTVKVPP-FIQPFEFPRF-SIGQRVFIPCVVVSGDLPITITWQKDGR 635
S ++ VK P F++ E + G + C V +G PI ITW + R
Sbjct: 4281 S-NVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKV-TGTPPIKITWFANDR 4338
Query: 636 PIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ 695
I S + ++ T+ LR++++ + +G Y C A+NEA + S +IV+ P F +
Sbjct: 4339 EIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTKE 4398
Query: 696 PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKH 755
+ + + V+L G P I W F + + + ++ SL I
Sbjct: 4399 FKPIEVLKEYDVMLLAEVAGTPPFEITW-FKDNTILRSGRKYKTFIQDHLV---SLQILK 4454
Query: 756 VVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEK 815
V D+G Y C+V+N+VG+ + S +T++ P +T + +G T G
Sbjct: 4455 FVAADAGEYQCRVTNEVGSSIC-SARVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSL 4513
Query: 816 PIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDR 875
PI V W K+ I + + V +S +++ + G + C A N G R
Sbjct: 4514 PITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEV-----KHDGKYVCQAKNDAGIQR 4568
Query: 876 GIIQLTVQEPP--------------DPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIE 921
L+V+EP DP +++K + IT +W F +T +
Sbjct: 4569 CSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITAKW---FKDGQELT---LG 4622
Query: 922 CKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADE 981
K K D+ K +S + S Y+ + +N +G+S + +
Sbjct: 4623 SKYKISVTDTVSILKIISTEKKD--------SGEYTFEV--QNDVGRSSCKARINVLDLI 4672
Query: 982 AAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVD 1041
P + ++ I I + H I + +E S ++F+ D
Sbjct: 4673 IPPSFTKKLKKMDSIKGSFIDLECIVAGSH---PISIQWFKDDQEISASEKYKFSF--HD 4727
Query: 1042 TSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATS 1101
+ E+ L+ + T A N+AG S + T+++ P Y E Q+ +
Sbjct: 4728 NTAFLEISQLEGTDSGT---YTCSATNKAGHNQCSGHL---TVKE-PPYFVEKPQSQDVN 4780
Query: 1102 PESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNI--TTTQPSLELDGLEKYT 1159
P + + +AL G + ++ + + G +++ T SLEL +
Sbjct: 4781 PN------TRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATD 4834
Query: 1160 NYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVF---VSWLPPLKLN 1216
+ + G +F + P+ V S F ++ P ++++
Sbjct: 4835 SGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVS 4894
Query: 1217 GIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEII 1276
+ + + + A+ R+ N V A +
Sbjct: 4895 WYLDGNEITAIQKHGISFIDGLATFQISGARVENSG---------TYVCEARNDAGTASC 4945
Query: 1277 TVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPS--LVTIDG 1334
++E K P + V D+ L C+ G P V W+K++ S T+
Sbjct: 4946 SIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTD 5005
Query: 1335 RRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTT--- 1391
R S+F + I D+G Y CI +N GS + ++ PP + + TT
Sbjct: 5006 RVSVF---NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLK 5062
Query: 1392 -----------SSSITLSWLPGD 1403
S I+++WL D
Sbjct: 5063 SSATFQSTVAGSPPISITWLKDD 5085
Score = 174 bits (440), Expect = 1e-42
Identities = 320/1537 (20%), Positives = 568/1537 (36%), Gaps = 161/1537 (10%)
Query: 117 HIKAVLREP---YTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRF 173
H ++EP +T +EDQ G AV +C V V W K+ ++ ++
Sbjct: 12275 HANLFVKEPPVEFTKPLEDQTVEEGATAVLEC----EVSRENAKVKWFKNGTEILKSKKY 12330
Query: 174 LITSTGA---LYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDP-ANSAPSILD 229
I + G L I D ED + Y C + T S L V P + D
Sbjct: 12331 EIVADGRVRKLVIHDCTPED-IKTYTCDAKDFKT-------SCNLNVVPPHVEFLRPLTD 12382
Query: 230 GFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LLIENIRP 285
K MA EL +W KD ++ ++ G L+I
Sbjct: 12383 LQVREKEMARFECEL-----SRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLL 12437
Query: 286 SDSGSYVCEVSNRYGTAKVIGRLYV-KQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQE 344
D Y CEV TA+ G L V ++ T + ++ S + L C V+ E
Sbjct: 12438 DDEAEYSCEVR----TARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVS-KPGAE 12492
Query: 345 LSWYRNGE-ILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLE 403
+ WY+ E I+ G+ +T L++ + D G Y C + + + V +
Sbjct: 12493 VIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGK----VKVH 12548
Query: 404 DGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEG 463
+ + IS + E +C++ P + W DD + G + + ++G
Sbjct: 12549 ELAAEFISKPQNLEILEGEKAEFVCSISKESFP-VQWKRDDKTLESGDKYDV----IADG 12603
Query: 464 NVVSYLNISSSQVRDGGVYRCTANNSAGV----VLYQARINVRGPASIRPMKNITAIAGR 519
L + + ++D G Y + V+ + RI V P+K+ +
Sbjct: 12604 KK-RVLVVKDATLQDMGTYVVMVGAARAAAHLTVIEKLRIVV-------PLKDTRVKEQQ 12655
Query: 520 DTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENN--GTLKLSDVQKEVDEGEYTCNV 577
+ +C V KW++N + + + + + + TL++ D + D+ Y ++
Sbjct: 12656 EVVFNCEV-NTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLD-DQANYNVSL 12713
Query: 578 LVQPQLSTSQSVHVTVKVPPF--IQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGR 635
+ + ++ V+ ++P + + V C V L +T+ W K+G
Sbjct: 12714 TNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKV--NRLNVTLKWTKNGE 12771
Query: 636 PIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ 695
+P V+ + L I + G Y A + + E LI+ P +FV
Sbjct: 12772 EVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAE---LLIIEAPTEFVEH 12828
Query: 696 PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGS---LL 752
DQ + +C + W + G + + + + + +GS L+
Sbjct: 12829 LEDQTVTEFDDAVFSCQLSREKA-NVKW-YRNGREIKEGK------KYKFEKDGSIHRLI 12880
Query: 753 IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAH 812
IK +D Y C V + S++ +IP I P L G +
Sbjct: 12881 IKDCRLDDECEYACGVEDRK----SRARLFVEEIPVEIIRPPQDILEAPGADVVFLAELN 12936
Query: 813 GEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYG 872
+K + V+W + + ++ ++S E I LQI D G + A +
Sbjct: 12937 KDK-VEVQWLRNNMVVVQGDKHQMMS-----EGKIHRLQICDIKPRDQGEYRFIAKDK-- 12988
Query: 873 EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPIT---GYDIECKNKSDSW 929
E R ++L P+I+ D + D P+T YD K +++ +
Sbjct: 12989 EARAKLELAAA-----PKIKTADQD---------LVVDVGKPLTMVVPYDAYPKAEAEWF 13034
Query: 930 DSAQ----RTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD 985
+ +T D + + S I++ ++ +N+ GK+E L +
Sbjct: 13035 KENEPLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVID----VP 13090
Query: 986 GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGD 1045
GP + + + + + W+ P + II GY + R+ + +++ D +
Sbjct: 13091 GPVRNLEVTETFDGEVSLAWEEPLTDGGSKII-GYVVERRDIKR----KTWVLATDRAES 13145
Query: 1046 SEVYTLDNLNKF-TQYGLVVQACNRAGTGP---SSQEIITTTLEDVPSYPPENVQAIATS 1101
E +T+ L K +Y V A NR GTG + + + DVP PP NV +
Sbjct: 13146 CE-FTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPG-PPLNVTITDVN 13203
Query: 1102 PESISISWSTLS----KEALNGI--LQGFRVIYWANLMDGELGEIKNITTTQPSLELDGL 1155
+S++W E N + L+ I W M ++ T ++G
Sbjct: 13204 RFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDV----VEGQ 13259
Query: 1156 EKYTNYSIQVLAFTRAGDGVRSEQI-FTRTKEDV--PGPPAGVKAAAASASMVFVSWLPP 1212
E YS +V A R G G S F + + + P PP + ++ + S V + W PP
Sbjct: 13260 E----YSFRVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPP 13315
Query: 1213 LKLNG--IIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRG 1270
LK G I+ C I +Y++ L + +Y V A AG
Sbjct: 13316 LKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAGVS 13375
Query: 1271 NSSEII---TVEPLAKAPARILT-FSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGT 1326
+ SEI+ T + P L+ F + I + + G P P W G
Sbjct: 13376 DPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCF---GD 13432
Query: 1327 PSLVTIDG--RRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR 1384
L T D +++ + +I + D G Y+ N + +++ V P P+
Sbjct: 13433 KVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPK 13492
Query: 1385 -LTVSKTTSSSITLSWLP-GDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLK 1442
L T S+ L+W P D+GGS + GY+++ E + + W ++ + + +L
Sbjct: 13493 ELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVMDFVTDLEFTVPDLV 13552
Query: 1443 CGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGW--- 1499
G Y F + A+N GPG + + E + E + T + + W
Sbjct: 13553 QGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKWRDRTANSI-FLTWDPP 13611
Query: 1500 -NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAE 1558
NDGG I + +E P G+ W + L+E WY +++ N G ++
Sbjct: 13612 KNDGGSRIKGYIVERCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASK 13671
Query: 1559 KQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKM 1595
+ + P I V+ GLT G K+
Sbjct: 13672 PSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKI 13708
Score = 167 bits (423), Expect = 1e-40
Identities = 207/911 (22%), Positives = 355/911 (38%), Gaps = 93/911 (10%)
Query: 31 LQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSS 90
L+E S + ++ C G PP+++ W+ G EI + + T + +
Sbjct: 7688 LKETNGLSGSSVVMECKVYGSPPISVSWF-HEGNEISSGRKYQTTLTDNTCAL------T 7740
Query: 91 FSTLIHDNT--YYCTAENPSGKIRSQDVHIKAVLREP--YTVRVEDQKTMRGNVAVFKCI 146
+ L ++ Y C A N +G S + +REP + + + + G F I
Sbjct: 7741 VNMLEESDSGDYTCIATNMAG---SDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSI 7797
Query: 147 IPSSVEAYITVVSWEKDTVSLVSGSRFLIT---STGALYIKDVQNEDGLYNYRCITRHRY 203
+ + VSW K + LV G R ++ S L + DV Y CI +
Sbjct: 7798 VKGTPPFS---VSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQS-GEYTCIVSNE- 7852
Query: 204 TGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNM 263
+ S + L++ PA + D + G+ + L G P W K+ +
Sbjct: 7853 --AGKASCTTHLYIKAPAKFVKRLNDYSIEK----GKPLILEGTFTGTPPISVTWKKNGI 7906
Query: 264 PLELSGRFQKTVTG----LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATIS 319
+ S R T T L I + D+G Y C + N G ++ + +P
Sbjct: 7907 NVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQ 7966
Query: 320 PRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINH-ENLIMDHMVKS 378
VK SVG SL C + GT + +SWY+ L P ++ N+ L+ + + +
Sbjct: 7967 LEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDIN 8026
Query: 379 DGGAYQCFVRKD--KLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLP 436
D G Y C ++SA ++ V + P + + PV C + G+
Sbjct: 8027 DSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSEPI 8086
Query: 437 TITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQ 496
+++W D P+ + + S + + + LNI + G Y CTA N G
Sbjct: 8087 SVSWYKDGKPLKDSPNVQTSFLDNT-----ATLNIFKTDRSLAGQYSCTATNPIGSASSS 8141
Query: 497 ARINV----RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR-QV 551
AR+ + P + + A+ G C V G + W K+S + + Q+
Sbjct: 8142 ARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQI 8201
Query: 552 AF-ENNGTLKLSDVQKEVDEGEYTCNVLVQ-------PQLSTSQSV---HVTVKVPPFIQ 600
++ EN+ L + V K D G+YTC + + QL+ + + T ++ ++
Sbjct: 8202 SYLENSAHLTVLKVDKG-DSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVE 8260
Query: 601 PFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLS 660
E F + RV +G PIT+ W K+ I + I + T L++
Sbjct: 8261 ETEGNSFKLEGRV-------AGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAG 8313
Query: 661 LMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIY---GKAVILNCSAEGYP 717
+ G YTC N+A + S ++++ P K V + + G+ V L+C +G
Sbjct: 8314 MNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSE 8373
Query: 718 VPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGS--LLIKHVVEEDSGYYLCKVSNDVGAD 775
I W G + + + ++G+ L ++ V + DSG Y+CK SN G+D
Sbjct: 8374 PIRIQW-LKAGREIKPSDRCSFS-----FASGTAVLELRDVAKADSGDYVCKASNVAGSD 8427
Query: 776 VSKSMYLTVKIPAM--------------ITSYPNTTLATQGQKKEMSCTAHGEKPIIVRW 821
+KS PA+ S P + + G+ V+W
Sbjct: 8428 TTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKW 8487
Query: 822 EKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLT 881
K + R + K G+E + L+I T + DSG + C A N +GE + L
Sbjct: 8488 TKGKWRQLNQGGRVFIHQK--GDE--AKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQ 8543
Query: 882 VQEPPDPPEIE 892
V E +IE
Sbjct: 8544 VDERKKQEKIE 8554
Score = 159 bits (403), Expect = 2e-38
Identities = 186/818 (22%), Positives = 315/818 (38%), Gaps = 111/818 (13%)
Query: 130 VEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNE 189
++D K + A+F+C + E ITV W KD L R I Q E
Sbjct: 3064 IKDIKVLEKKRAMFECEVS---EPDITV-QWMKDDQELQITDRIKI-----------QKE 3108
Query: 190 DGLYNYRCITRHRYTGETRQSNSARLFVSDPAN--SAPSILDGFDHRKAMAGQRVELPCK 247
Y +R + TR S++ + V N +A ++G D R + V++ K
Sbjct: 3109 K--YVHRLLIP-----STRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEK 3161
Query: 248 A-------LGHPEPDYRWLKDNMPLELSGR------FQKTVTGLLIENIRPSDSGSYVCE 294
+ + D W KD + + + ++ + + I R SD+G Y
Sbjct: 3162 QRAVVEFEVNEDDVDAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTFV 3221
Query: 295 VSNRYGTAKVIGRLYVKQP----LKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRN 350
+ LYV P + + P V+S G ++G ++SWY+
Sbjct: 3222 AGRNRSSVT----LYVNAPEPPQVLQELQPVTVQS--GKPARFCAVISGRPQPKISWYKE 3275
Query: 351 GEILNPGKNVRITGINHE-NLIMDHMVKSDGGAYQCFVRKDKLSAQ-------DYVQVVL 402
++L+ G + E L++ D Y C + D A + +VV
Sbjct: 3276 EQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVS 3335
Query: 403 EDGT-----PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQ 457
D P II+ + V S +P C V GT L ++W D I R++Q
Sbjct: 3336 PDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDLK-VSWYSKDKKIKPSRFFRMTQ 3394
Query: 458 MITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI---------- 507
+ L I+ + D G Y A+N+ G V A +++ P SI
Sbjct: 3395 FEDTY-----QLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIE 3449
Query: 508 ----------RPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNG 557
R ++ + G C + P +W+K + + + + ++
Sbjct: 3450 MEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREI-YESDKCSIRSSK 3508
Query: 558 TLKLSDVQKE--VDEGEYTCNVLVQ-PQLSTSQSVHVTVKVPPFI--QPFEFPRFSIGQR 612
+ ++ + VD GEYTC + +S + ++ VT PP +P F +G+
Sbjct: 3509 YISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTF-VGKA 3567
Query: 613 VFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIAR 672
C V +G I WQKDG + S I + + L +SNL++ G Y+C A
Sbjct: 3568 AKFICTV-TGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKAS 3626
Query: 673 NEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP 732
N+ A Q++LI+ P F+ + K V L C + T+ W G +P
Sbjct: 3627 NKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRKVTVTWS-KDGQKLP 3685
Query: 733 --QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMI 790
+ I +I L +K DSG Y+C SN+ G+ + + P+ +
Sbjct: 3686 PGKDYKICFEDKIATLEIPLAKLK-----DSGTYVCTASNEAGSSSCSATVTVREPPSFV 3740
Query: 791 TSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPE--MARYLVSTKEVGEEVIS 848
+ L G+ + C G I V W K ++ ++ + Y V+++ +
Sbjct: 3741 KKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAI------ 3794
Query: 849 TLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886
L I EDSG +SC A+N G D ++ ++EPP
Sbjct: 3795 -LDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPP 3831
Score = 154 bits (388), Expect = 1e-36
Identities = 180/718 (25%), Positives = 293/718 (40%), Gaps = 91/718 (12%)
Query: 883 QEPPDPPEI-EIKDVKARTITLRWTM-GFDGNSPITGYDIECKNK-SDSWDSAQRTKDVS 939
Q PP PP ++ D +++L W +DG SPI GY +E K SD+W +++
Sbjct: 19586 QYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNL- 19644
Query: 940 PQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN--------------ELTITADEAAP- 984
Q + + + Y R+YA N+IG S+PS+ E + AD
Sbjct: 19645 -QKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRKTL 19703
Query: 985 ---DGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVD 1041
G +++ ++TW P +L++ I G I ++ T
Sbjct: 19704 ILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRI--GLDIKSTDFDT------------ 19749
Query: 1042 TSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATS 1101
+N+NK+ ++ N G + I + D P PP NV S
Sbjct: 19750 ------FLRCENVNKYDAGKYILTLENSCG---KKEYTIVVKVLDTPG-PPVNVTVKEIS 19799
Query: 1102 PESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITT--TQPSLELDGLEKYT 1159
+S ++W + + I+ Y D E +TT ++ S + LE+
Sbjct: 19800 KDSAYVTWEPPIIDGGSPIIN-----YVVQKRDAERKSWSTVTTECSKTSFRVANLEEGK 19854
Query: 1160 NYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI- 1218
+Y +V A G G E PGP +K + S S + W P G
Sbjct: 19855 SYFFRVFAENEYGIGDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSR 19914
Query: 1219 IRKYTVFCSHPYPTVISEFEASPDSFS--YRIPNLSRNRQYSVWVVAVTSAGRGNSSEII 1276
I Y V + T ++++ S S Y +L+ ++Y+ V A G G SEI
Sbjct: 19915 IIGYVV----DFLTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEI- 19969
Query: 1277 TVEPLAKAPARILTFSGTVTTPWMKD------IVLPCKAVGDPSPAVKWMKDSNGTPSLV 1330
TV A L G ++ + +P K G P+P+V W K G L
Sbjct: 19970 TVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIK--GKPAPSVSWKK---GEDPLA 20024
Query: 1331 TIDGRRSIFS---NGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR--L 1385
T D R S+ S N + I+ + D+G Y+ N G+ E ++++V P P +
Sbjct: 20025 T-DTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPI 20083
Query: 1386 TVSKTTSSSITLSWLPG-DNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCG 1444
+ T+ ++TL W P D+GGS I YIL+ + + +W + + + ++R+ L G
Sbjct: 20084 KFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEG 20143
Query: 1445 TWYKFTLTAQN--GVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWND- 1501
Y F ++A+N GVG G SE I A+ P + + V L W D
Sbjct: 20144 MEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNI-VDVRHDSVSLT---WTDP 20199
Query: 1502 ---GGCPITSFTLEYRPFGTTVWTTAQRTSL-SKSYILYDLQEATWYELQMRVCNSAG 1555
GG PIT + LE++ + +W A +T + + + + L E YE ++ N AG
Sbjct: 20200 KKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAG 20257
Score = 144 bits (363), Expect = 9e-34
Identities = 199/804 (24%), Positives = 315/804 (39%), Gaps = 73/804 (9%)
Query: 794 PNTTLATQGQKKEMSCTAHGEKPIIVRWEK-EDRIINPEMARYLVSTKEVGEEVISTLQI 852
P G+K + +G+ +W+K ED ++ + +L K + S L I
Sbjct: 18905 PEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVT---SSHLAVHKA---DSSSILII 18958
Query: 853 LPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPE--IEIKDVKARTITLRWTMGF- 909
R+DSG++S A NS G D I++ V + P PP+ +I D+ A +L W +
Sbjct: 18959 KDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLE 19018
Query: 910 DGNSPITGYDIE-CKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGK 968
DG S IT Y +E C W +A S S + + P Y R+ A+NR G
Sbjct: 19019 DGGSNITNYIVEKCDVSRGDWVTAL----ASVTKTSCRVGKLIPGQEYIFRVRAENRFGI 19074
Query: 969 SEPSNELTITADEAAPDGPPQE---VHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYR 1025
SEP + A P G P E + ++ I V W P + II GY I +
Sbjct: 19075 SEPLTSPKMVAQ--FPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPII-GYLIERK 19131
Query: 1026 EYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLE 1085
E N + + DT S Y L + +Y + A N+AG+ P S+ T
Sbjct: 19132 E----RNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTAR 19187
Query: 1086 DVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITT 1145
+P PP + I + ++S+ W+ + + I+ F A + G+ N
Sbjct: 19188 -MPVDPPGKPEVIDVTKSTVSLIWARPKHDGGSKIIGYF---VEACKLPGDKWVRCNTAP 19243
Query: 1146 TQPSLE---LDGLEKYTNYSIQVLAFTRAGDGVRSE--QIFTRTKEDVPGPPAGVKAAAA 1200
Q E GLE+ Y + +A T SE T E+VP P + A
Sbjct: 19244 HQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVP-PRIDLSVAMK 19302
Query: 1201 SASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTV--------ISEFEASPDSFSYRIPNL- 1251
S V + TVF P PTV + E + + L
Sbjct: 19303 SLLTVKAG-------TNVCLDATVF-GKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLE 19354
Query: 1252 --SRNRQYSVWVVAVTSAGRGNSSEIITVEPLAK-APARILTFSGTVTTPWMKDIVLPCK 1308
S NR+ S G+ S I ++ L K P + + + M P +
Sbjct: 19355 LFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLE 19414
Query: 1309 AVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSD 1368
G K P+ + I S + + ++ + + C N D
Sbjct: 19415 DGGSEITNYIVDKRETSRPNWAQVSATVPITS--CSVEKLIEGHEYQFRICAENKYGVGD 19472
Query: 1369 EIILNLQVQVPPDQP-----RLTVSKTTSSSITLSWL-PGDNGGSSIRGYILQYSEDNSE 1422
+ + P P +S T +T+SW P D+GGS I GY+L+ E +
Sbjct: 19473 PVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAV 19532
Query: 1423 QWGSFPISP-SERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQ 1481
W P ER+ + L+ GT Y+F +TA N GPG+ S+ +A ++PQ+
Sbjct: 19533 NWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKA-AYARDPQYPPGP 19591
Query: 1482 ELFASI-NTTRVRLNLIGWN----DGGCPITSFTLEYRPFGTTVWTTAQ-RTSLSKS-YI 1534
F + +TTR ++L W DGG PI + +E + + W +L K+ +
Sbjct: 19592 PAFPKVYDTTRSSVSL-SWGKPAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFE 19650
Query: 1535 LYDLQEATWYELQMRVCNSAGCAE 1558
+ L E T Y+ ++ N G ++
Sbjct: 19651 VTGLMEDTQYQFRVYAVNKIGYSD 19674
Score = 142 bits (359), Expect = 3e-33
Identities = 227/1033 (21%), Positives = 401/1033 (38%), Gaps = 115/1033 (11%)
Query: 620 VSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVE 679
VSG P T+TW + R +P TI+ +SS+ I N H G Y+ +A+NEA E
Sbjct: 16548 VSGKPPPTVTWNMNERTLPQE--ATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAG--E 16603
Query: 680 HQSQLIVRV--PPKFVVQPRDQDGIYGKAVILNCSAE----GYPVPTIVWK---FSKGAG 730
+ +IV V P V P + ++ L + G P+ V + + A
Sbjct: 16604 RKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAW 16663
Query: 731 VPQFQPIAL-NGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAM 789
P + N +Q L G + E+S +G V S L ++ P
Sbjct: 16664 TPVTYTVTRQNATVQGLIQGKAYFFRIAAENS--------IGMGPFVETSEALVIREPIT 16715
Query: 790 ITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVST----KEVGEE 845
+ P + K ++ T + K ++ IIN + L+ T K +
Sbjct: 16716 VPERPEDLEVKEVTKNTVTLTWNPPK-----YDGGSEIINYVLESRLIGTEKFHKVTNDN 16770
Query: 846 VISTLQILPTVRE-DSGFFSCHAINSYGEDRGII---QLTVQEPPDPPEIEIKDVKARTI 901
++S + ++E D+ + A+N G+ + +T ++ PP + + TI
Sbjct: 16771 LLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTI 16830
Query: 902 TLRWTMGFDGN-----SPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTY 956
+ G P + K+++D + + +P + I S +
Sbjct: 16831 RVGEAFALTGRYSGKPKPKVSW---FKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSG 16887
Query: 957 SIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPK----KHL 1012
+ +N G + ++ + P GP V + ++ + ++WK P +
Sbjct: 16888 KYCVVVENSTGSRKGFCQVNVVDRPGPPVGP---VSFDEVTKDYMVISWKPPLDDGGSKI 16944
Query: 1013 QNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGT 1072
N II ++G + + V ++ + L + Y + A N G
Sbjct: 16945 TNYIIEKKEVGKDVW----------MPVTSASAKTTCKVSKLLEGKDYIFRIHAENLYGI 16994
Query: 1073 GPSSQEIITTTLED-----VPSYPPENVQAIATSPESISISWSTL---SKEALNGILQGF 1124
S +++ +++ VP P + + T +S ++W+ K N IL+
Sbjct: 16995 ---SDPLVSDSMKAKDRFRVPDAPDQPIVTEVTK-DSALVTWNKPHDGGKPITNYILEKR 17050
Query: 1125 RVIY--WANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDG---VRSEQ 1179
+ WA + + P L L+G + Y +V A G G S+
Sbjct: 17051 ETMSKRWARVTKDPIHPYTKFRV--PDL-LEGCQ----YEFRVSAENEIGIGDPSPPSKP 17103
Query: 1180 IFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPL-----KLNGIIRKYTVFCSHPYPTVI 1234
+F + P PP +A + + V ++W PP K+ G I +Y +
Sbjct: 17104 VFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRAN 17163
Query: 1235 SEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI---ITVEPLAKAPARILTF 1291
E+ P++ Y++ L + Y V+AV +AG + + + + V+ + P IL
Sbjct: 17164 HTPESCPET-KYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDA 17222
Query: 1292 SGTVTTPWMKDIVLPCKAV--GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI-IRT 1348
+ L A+ G P P V W K+ P+ ID + GS + IR
Sbjct: 17223 NMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARID----VTPVGSKLEIRN 17278
Query: 1349 VKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSWL-PGDNGG 1406
ED G YS N GS + + + V P PR L VS+ S L+W P D+GG
Sbjct: 17279 AAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLDDGG 17338
Query: 1407 SSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEI- 1465
S I Y+++ + S QW + ++S+ ++L G Y F + A+N G G E
Sbjct: 17339 SVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETP 17398
Query: 1466 --IEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN----DGGCPITSFTLEYRPFGTT 1519
I+A P K+ ++ + ++L+ WN DGG PIT + +EY+ GT
Sbjct: 17399 KPIKALDPLHPPGPPKD---LHHVDVDKTEVSLV-WNKPDRDGGSPITGYLVEYQEEGTQ 17454
Query: 1520 VWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKS 1579
W +T + ++ LQ+ Y +++ N G + +PP ++
Sbjct: 17455 DWIKF-KTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTI-PIECQEKLVPPSVEL 17512
Query: 1580 VVQNEEGLTTNEG 1592
V+ EGL G
Sbjct: 17513 DVKLIEGLVVKAG 17525
Score = 140 bits (354), Expect = 1e-32
Identities = 188/789 (23%), Positives = 317/789 (40%), Gaps = 81/789 (10%)
Query: 863 FSCHAINSYGEDRGIIQLTV--QEPPDPPEIEIK-DVKARTITLRWTMGFDGNSPITGYD 919
F A+N GE + L V Q+ PP I+++ V+ TI ++ + +TG
Sbjct: 15367 FRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLP 15426
Query: 920 IE----CKNKS---DSWDSAQRTKDVSPQLNSATIIDI-----HPSSTYSIRMYAKNRIG 967
+ KN++ D+ Q TK+ + + T + I TY++ A NR+G
Sbjct: 15427 MPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVT--ASNRLG 15484
Query: 968 KSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNG--IIRGYQIGYR 1025
S + + PP+ + + I ++S +TW AP L NG I Y I R
Sbjct: 15485 ----SVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAP---LDNGGSEITHYVIDKR 15537
Query: 1026 EYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPS--SQEIITTT 1083
+ S + V + + Y + L QY V+A N+ G S +++
Sbjct: 15538 DASRK---KAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDKVVIQD 15594
Query: 1084 LEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVI-------YWANLMDGE 1136
+P PP + +A + S+ +SW T + + G+ + YW+ +
Sbjct: 15595 PYRLPG-PPGKPKVLARTKGSMLVSW-TPPLDNGGSPITGYWLEKREEGSPYWSRVSRAP 15652
Query: 1137 LGEI--KNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDV---PGP 1191
+ ++ K + P L L+G++ Y + +A AG G SE D PGP
Sbjct: 15653 ITKVGLKGVEFNVPRL-LEGVK----YQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGP 15707
Query: 1192 PAGVKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPYPTV---ISEFEASPDSFSYR 1247
P+ + + S + + W PP K G I+ Y V T ++E + +
Sbjct: 15708 PSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECV 15767
Query: 1248 IPNLSRNRQYSVWVVAVTSAGRGNSSEI---ITVEPLAKAPARILTFSGT--VTTPWMKD 1302
+PNL R+Y V AV AG S+ I + + P + +
Sbjct: 15768 VPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQ 15827
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSL------VTIDGRRSIFSNGS-FIIRTVKAEDSG 1355
I +P G P+P W D ++ + D + N S II K +G
Sbjct: 15828 IRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTG 15887
Query: 1356 YYSCIANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSW-LPGDNGGSSIRGYI 1413
YS A N G ++V P P+ L VS T S LSW +P D+GG I+GY+
Sbjct: 15888 KYSITAKNKAGQKTANCRVKVMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYV 15947
Query: 1414 LQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGK 1473
++ + + W ++ + +L Y F + A+N G G E I+ +T +
Sbjct: 15948 IEKRTIDGKAWTKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQ-RTTAR 16006
Query: 1474 EPQFSKEQELFASINTTRVRLNLIGW----NDGGCPITSFTLE---YRPFGT--TVWTTA 1524
+P + + + I + W NDGG P+T + +E + P GT W
Sbjct: 16007 DPIYPPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQC 16066
Query: 1525 QRTSLSK-SYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLI--KSVV 1581
+ + + + + DL E YE +++ N+AG ++ A + +PP I K +
Sbjct: 16067 NKRDVEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFM 16126
Query: 1582 QNEEGLTTN 1590
+ EEG N
Sbjct: 16127 EVEEGTNVN 16135
Score = 134 bits (336), Expect = 1e-30
Identities = 178/795 (22%), Positives = 307/795 (38%), Gaps = 96/795 (12%)
Query: 813 GEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYG 872
G V W K+ + + E R VS+ + +++L I +ED G + NS G
Sbjct: 25420 GRPQATVNWRKDGQTLK-ETTRVNVSSSKT----VTSLSIKEASKEDVGTYELCVSNSAG 25474
Query: 873 EDRGIIQLTVQEPPDPP-EIEIKDVKARTITLRWT-MGFDGNSPITGYDIECK-NKSDSW 929
I + V + P PP I I +V +IT+ W +DG I+ Y +E K S +W
Sbjct: 25475 SITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTW 25534
Query: 930 DSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITAD-EAAPDGPP 988
+ + S I+ + S Y R+ A+NR GKS S + A+ +P GPP
Sbjct: 25535 HIVSQ----AVARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPP 25590
Query: 989 QEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFN-IISVDTSGDSE 1047
+ + ++ VTW+ P + +I GY + Y+E S+ + N I+ DT
Sbjct: 25591 GTPKVVHATKSTMLVTWQVPVNDGGSRVI-GYHLEYKERSSILWSKANKILIADTQ---- 25645
Query: 1048 VYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISI 1107
+ L++ Y V A N AG G S+ D P PP + + +S+S+
Sbjct: 25646 -MKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARD-PCDPPGQPEVTNITRKSVSL 25703
Query: 1108 SWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLA 1167
WS + + G+ ++ L DG + + E+ L + Y +V A
Sbjct: 25704 KWSKPHYDG-GAKITGY-IVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFA 25761
Query: 1168 FTRAGDGVRSEQIFTR---TKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTV 1224
A D V T K+DV P V ++ V LK+N I
Sbjct: 25762 -RNAADSVSEPSESTGPIIVKDDV--EPPRVMMDVKFRDVIVVKAGEVLKINADI----- 25813
Query: 1225 FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKA 1284
P P + S+ + + +++ ++ ++TV+ +
Sbjct: 25814 -AGRPLPVI-----------SWAKDGIEIEERARTEIIST------DNHTLLTVKDCIRR 25855
Query: 1285 PA--RILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNG 1342
+LT T + + + CK + P P ++ + T ++ R G
Sbjct: 25856 DTGQYVLTLKNVAGT---RSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGG 25912
Query: 1343 S----FIIRTVKAEDSGYYSCIAN------------------------NNWGSDEIILNL 1374
+ +I+ + + C N +G E + ++
Sbjct: 25913 ADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESV 25972
Query: 1375 QVQ------VPPDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSF 1427
++ VP L ++ T S+TL W P +GGS I GYI++ E NS +W
Sbjct: 25973 AIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRV 26032
Query: 1428 PISP-SERSYRLENLKCGTWYKFTLTAQNGVG---PGRISEIIEAKTLGKEPQFSKEQEL 1483
P + + L+ G Y++ + A+N G P S +I A+ P + ++
Sbjct: 26033 NKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKI 26092
Query: 1484 FASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATW 1543
S TT + DGG PIT +T+EY+ T W T+ ++ Y + L
Sbjct: 26093 VDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAE 26152
Query: 1544 YELQMRVCNSAGCAE 1558
Y +++ N G ++
Sbjct: 26153 YVFRVKSVNKVGASD 26167
Score = 133 bits (335), Expect = 2e-30
Identities = 157/698 (22%), Positives = 286/698 (40%), Gaps = 50/698 (7%)
Query: 881 TVQEPPDPPEIEIKDVKARTITLRWTMG-FDGNSPITGYDIECK-NKSDSWDSAQRTKDV 938
TV +P P + D +I++ W +DG S ITGY +E + D W T
Sbjct: 21752 TVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIV--TPPA 21809
Query: 939 SPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISS 998
+ S TI + + Y IR+YA N G EP+ L +A P E+ L+
Sbjct: 21810 GLKATSYTITGLTENQEYKIRIYAMNSEGLGEPA--LVPGTPKAEDRMLPPEIELDADLR 21867
Query: 999 QSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFT 1058
+ + + + I+G +++ + S++++ + + N+N+F
Sbjct: 21868 KVVTIRACCTLRLFVP--IKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFD 21925
Query: 1059 QYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALN 1118
++ N +G S + + D P PP++++ + S++++W
Sbjct: 21926 SGKYILTVENSSG---SKSAFVNVRVLDTPG-PPQDLKVKEVTKTSVTLTWDP------- 21974
Query: 1119 GILQGFRVI--YWANLMDGELGEIKNITTT--QPSLELDGLEKYTNYSIQVLAFTRAGDG 1174
+L G I Y + + T + S ++D L++ +Y +VLA G G
Sbjct: 21975 PLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIG 22034
Query: 1175 VRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPP-----LKLNGIIRKYTVFCSHP 1229
+ +E + + P PP + + + V +SW P ++ G I + S
Sbjct: 22035 LPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDK 22094
Query: 1230 YPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI---ITVEPLAKAPA 1286
+ T A+ I L + +YS V A G + ++ + + L PA
Sbjct: 22095 WATC-----ATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPA 22149
Query: 1287 RILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFII 1346
L F+ T T +D+ + +G P+PAV W KD+ ++ S +N I
Sbjct: 22150 FKLLFN-TFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAE-STENNSLLTI 22207
Query: 1347 RTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR--LTVSKTTSSSITLSWLPGD- 1403
+ ED G+Y N+ G LN+ V P P + + + T+ SITLSW P
Sbjct: 22208 KDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKY 22267
Query: 1404 NGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRIS 1463
+GGSSI YI++ + ++ W + + + + LK G Y+F + A+N G S
Sbjct: 22268 DGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGK---S 22324
Query: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLNL-IGWN----DGGCPITSFTLEYRPFGT 1518
+ ++ + F + T R ++ + WN DGG + + LE + +
Sbjct: 22325 TYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYHLERKERNS 22384
Query: 1519 TVWTTAQRTSLSKS-YILYDLQEATWYELQMRVCNSAG 1555
+W +T + ++ + L+E YE ++ N G
Sbjct: 22385 ILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVG 22422
Score = 132 bits (333), Expect = 3e-30
Identities = 305/1463 (20%), Positives = 564/1463 (38%), Gaps = 198/1463 (13%)
Query: 241 RVELPCKALGHPEPDYRWLKDNMPLELSGRFQKT--VTGLLIENIRPSDSGSYVCEVSNR 298
R+ +P K G P P+ W KDN+ L+ + T T L+I D+G +V + N
Sbjct: 20795 RIFVPIK--GRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENP 20852
Query: 299 YGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGK 358
G K+ +V + G ++L + + L W + +++ G
Sbjct: 20853 AGK-------------KSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHW--DLPLIDGGS 20897
Query: 359 NVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLS--AQDYVQVVLED----GTPKIIS- 411
+ + + ++C + LS + + +V+ E+ G P +
Sbjct: 20898 RITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTE 20957
Query: 412 -AFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN------ 464
+ + SP + +++M K T ++ W P GGS +I ++
Sbjct: 20958 PVKASEAPSPPDSLNIMDITKSTV--SLAWP---KPKHDGGSKITGYVIEAQRKGSDQWT 21012
Query: 465 ---VVSYLNISSSQVRDGGVY--RCTANNSAG----------VVLYQA---RINVRGPAS 506
V L + +G Y + A NSAG +V Q +++RG
Sbjct: 21013 HITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQ 21072
Query: 507 IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQK 566
K + A AG + + V+G P ++ W K +L R V FE T + ++ +
Sbjct: 21073 ----KLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQR-VNFETTATSTILNINE 21127
Query: 567 EV--DEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDL 624
V D G Y T++++ V IQ + P G F VS D
Sbjct: 21128 CVRSDSGPYPL---------TARNIVGEVGDVITIQVHDIPGPPTGPIKFDE---VSSDF 21175
Query: 625 PITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQL 684
+T +W P GV I N + + + + +A ++L
Sbjct: 21176 -VTFSWD----PPENDGGVPISNY-------VVEMRQTDSTTWVELATTVIRTTYKATRL 21223
Query: 685 IVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRI- 743
+ +F V+ +++ G+ G + C YP +K G PQ + +
Sbjct: 21224 TTGLEYQFRVKAQNRYGV-GPGITSACIVANYP-----FKVPGPPGTPQVTAVTKDSMTI 21277
Query: 744 ---QVLSNGS--LLIKHVVEEDSGYYLCKVSND--VGADVSKSMYLTVKIPAMIT----- 791
+ LS+G +L HV ++ L + + V ++ KS LT I
Sbjct: 21278 SWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAEN 21337
Query: 792 -------SYPNTTLAT------QGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVS 838
S P+ + G+ ++ T H + ++W K + ++ Y+V
Sbjct: 21338 MAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRH---TVTLKWAKPEYTGGFKITSYIVE 21394
Query: 839 TKEVGE---------EVISTLQILPTVREDSGF-FSCHAINSYGE----DRGIIQLTVQE 884
+++ ++ + + ED+ + F A N+ G +T ++
Sbjct: 21395 KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRD 21454
Query: 885 PPDPPEIEIKDVKAR-TITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLN 943
+ P+I++ DVK + T+ L+ F + ++G S + T + ++
Sbjct: 21455 DVEAPKIKV-DVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIA 21513
Query: 944 SATIIDIHPSSTY----SIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQ 999
+ ++ ST + + A N G ++ + + P+GP + + ++S+
Sbjct: 21514 DFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGP---LAVTEVTSE 21570
Query: 1000 SIRVTWKAPKKHLQNG--IIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLD--NLN 1055
++W P L +G I Y + RE S + + + + +V L L
Sbjct: 21571 KCVLSWFPP---LDDGGAKIDHYIVQKRETS-------RLAWTNVASEVQVTKLKVTKLL 21620
Query: 1056 KFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSK 1114
K +Y V A N+ G G P E + P PP+N + + +S+ + W
Sbjct: 21621 KGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDS 21680
Query: 1115 EALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDG 1174
+ + I+ ++ + + T T ++ GL + Y +++A AG
Sbjct: 21681 DGGSEIIN--YIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGIS 21738
Query: 1175 VRSEQI-FTRTKEDV--PGPPAGVKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPY 1230
S F + + V PGPP + S S + ++W P+ G I Y V + P
Sbjct: 21739 APSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPE 21798
Query: 1231 PTV--ISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARI 1288
I A + SY I L+ N++Y + + A+ S G G E V KA R+
Sbjct: 21799 EDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLG---EPALVPGTPKAEDRM 21855
Query: 1289 LTFSGTVTTPWMKDIVL----------PCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSI 1338
L + K + + P K G P+P VKW +D + +I+ S
Sbjct: 21856 LPPEIELDADLRKVVTIRACCTLRLFVPIK--GRPAPEVKWARDHGESLDKASIE---ST 21910
Query: 1339 FSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITL 1397
S I+ V DSG Y N+ GS +N++V P P+ L V + T +S+TL
Sbjct: 21911 SSYTLLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTL 21970
Query: 1398 SWLPGD-NGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNG 1456
+W P +GGS I+ YI++ E + + + + + S++++ L+ G Y F + A+N
Sbjct: 21971 TWDPPLLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENE 22030
Query: 1457 VGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGW----NDGGCPITSFTLE 1512
G G +E E+ + P + L ++ TR ++L W +DGG I + +E
Sbjct: 22031 YGIGLPAETAESVKASERPLPPGKITL---MDVTRNSVSL-SWEKPEHDGGSRILGYIVE 22086
Query: 1513 YRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGST 1572
+ G+ W T ++++ I L + Y ++ N G ++ + +
Sbjct: 22087 MQTKGSDKWATCATVKVTEATIT-GLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLV 22145
Query: 1573 IPPLIKSVVQNEEGLTTNEGLKM 1595
IPP K ++ N + E LK+
Sbjct: 22146 IPPAFK-LLFNTFTVLAGEDLKV 22167
Score = 131 bits (330), Expect = 6e-30
Identities = 226/994 (22%), Positives = 375/994 (37%), Gaps = 114/994 (11%)
Query: 627 TITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV 686
TI W K + + + + I + DF +SL + + + +GNY A+N A + V
Sbjct: 22574 TIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAG------ERSV 22627
Query: 687 RVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL 746
V K + +P +G VI +AE T+ WK G + R
Sbjct: 22628 TVNVKVLDRPGPPEG---PVVISGVTAEKC---TLAWKPPLQDGGSDIINYIVERR---- 22677
Query: 747 SNGSLLIKHVVEEDSGYYLCKVS---------------NDVGA-DVSKSMYLTVKIPAMI 790
S L+ VV+ + CKV+ N G + +S + K P ++
Sbjct: 22678 -ETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVV 22736
Query: 791 TSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKE--------V 842
P T K M IV WE+ E+ Y++ ++
Sbjct: 22737 PDAPKAPEVTTVTKDSM----------IVVWERPASDGGSEILGYVLEKRDKEGIRWTRC 22786
Query: 843 GEEVISTLQILPT--VREDSGFFSCHAINSYGEDRGIIQLTVQE-------PPDPPEIEI 893
+ +I L++ T + F A N+ G Q+ P P ++
Sbjct: 22787 HKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKV 22846
Query: 894 KDVKARTITLRWTMG-FDGNSPITGYDIE-CKNKSDSWDSAQRTKDVSP-QLNSATIIDI 950
D+ ++ L W+ +DG I GY +E C W ++ + +++
Sbjct: 22847 IDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLLEK 22906
Query: 951 HPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWK---- 1006
H Y+ R+ A N+ G E ++ E + P ++ LE +IR
Sbjct: 22907 HE---YNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLF 22963
Query: 1007 APKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQA 1066
P K ++ ++ G II V +S S V LDN+N++ +
Sbjct: 22964 VPIKGRPTPEVKWGKVD------GEIRDAAIIDVTSSFTSLV--LDNVNRYDSGKYTLTL 23015
Query: 1067 CNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRV 1126
N +GT +T + D PS PP N++ + +S+SI+W +L G
Sbjct: 23016 ENSSGT---KSAFVTVRVLDTPS-PPVNLKVTEITKDSVSITWEP-------PLLDGGSK 23064
Query: 1127 I--YWANLMDGELGEIKNITTT--QPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFT 1182
I Y + + T + S ++D L++ +Y +V A G G+ ++
Sbjct: 23065 IKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADP 23124
Query: 1183 RTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPYPTVISEFEASP 1241
+VP PP + + + V +SW P G I +Y V + SE A
Sbjct: 23125 IKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSEC-ARV 23183
Query: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI---ITVEPLAKAPARILTFSGTVTTP 1298
S I NL++ +Y VVAV GR + + I + L P FS + +
Sbjct: 23184 KSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFS-SYSVQ 23242
Query: 1299 WMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYS 1358
+D+ + G P P + W KD I+ S+ I T K +D G Y
Sbjct: 23243 VGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHK-DDGGQYG 23301
Query: 1359 CIANNNWGSDEIILNLQVQVPPDQPRLTVS--KTTSSSITLSWLPG-DNGGSSIRGYILQ 1415
N G + + PD P+ V ++ SITLSW P GG I YI+Q
Sbjct: 23302 ITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQ 23361
Query: 1416 YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRI--SEIIEAKTLGK 1473
+ + W + + + ++ LK GT Y+F + A+N G S+ I A+ K
Sbjct: 23362 KRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYK 23421
Query: 1474 EPQFSKEQELFASINTTRVRLNLIGW----NDGGCPITSFTLEYRPFGTTVWTTAQRTSL 1529
EP A + V I W N+GG P+ + LE + + +WT +T +
Sbjct: 23422 EPGPPGTPFATAISKDSMV----IQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTII 23477
Query: 1530 -SKSYILYDLQEATWYELQMRVCNSAGCAEKQAN 1562
+ +L+E YE ++ N G + N
Sbjct: 23478 HDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKN 23511
Score = 131 bits (329), Expect = 8e-30
Identities = 177/728 (24%), Positives = 280/728 (38%), Gaps = 105/728 (14%)
Query: 884 EPPDPP-EIEIKDVKARTITLRWTMG-FDGNSPITGYDIECKNK--SDSWDSAQRTKDVS 939
EPP PP + D +ITL W +DG +PI GY +E + K S D + + +
Sbjct: 18495 EPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDEGWKRCNAA 18554
Query: 940 PQL--NSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLE--- 994
QL T+ + + Y R+ A+N++G P+ + + P E+ L+
Sbjct: 18555 AQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILE--PPEIDLDASM 18612
Query: 995 ----------PISSQSI-------RVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNI 1037
PI +I +VTW+ K + N + +G + F +
Sbjct: 18613 RKLVIVRAGCPIRLFAIVRGRPAPKVTWR--KVGIDNVVRKG------QVDLVDTMAFLV 18664
Query: 1038 ISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ---EIITTTLEDVPSYPPEN 1094
I T DS Y+L +N + + V GP S +T T V PPEN
Sbjct: 18665 IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPEN 18724
Query: 1095 ------VQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQP 1148
I E+ +WST++ E F V NL+ G
Sbjct: 18725 DGGSQVTHYIVEKREADRKTWSTVTPEVKK---TSFHV---TNLVPGN------------ 18766
Query: 1149 SLELDGLEKYTNYSIQVLAFTRAGDGVRSE---QIFTRTKEDVPGPPAGVKAAAASASMV 1205
Y +V A G GV ++ + P PP ++ + +
Sbjct: 18767 -----------EYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSA 18815
Query: 1206 FVSWLPPL-----KLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVW 1260
++WLPPL K++G I Y +E+ D S + L ++Y
Sbjct: 18816 TLAWLPPLRDGGAKIDGYITSYRE--EEQPADRWTEYSVVKD-LSLVVTGLKEGKKYKFR 18872
Query: 1261 VVAVTSAGRGNSSEIITVEPLAKA--PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVK 1318
V A + G E V + P +IL +T K + + G P P K
Sbjct: 18873 VAARNAVGVSLPREAEGVYEAKEQLLPPKIL-MPEQITIKAGKKLRIEAHVYGKPHPTCK 18931
Query: 1319 WMKDSNGTPSLVTID--GRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV 1376
W K G +VT S+ II+ V +DSGYYS A N+ G+D + + V
Sbjct: 18932 WKK---GEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVV 18988
Query: 1377 Q--VPPDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSE 1433
P QP +S + + +LSW +P ++GGS+I YI++ + + W + S ++
Sbjct: 18989 MDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTK 19048
Query: 1434 RSYRLENLKCGTWYKFTLTAQNGVGPGRISE-IIEAKTLGKEPQFSKEQELFASINTTRV 1492
S R+ L G Y F + A+N G ISE + K + + P + A +
Sbjct: 19049 TSCRVGKLIPGQEYIFRVRAENRFG---ISEPLTSPKMVAQFPFGVPSEPKNARVTKVNK 19105
Query: 1493 RLNLIGW----NDGGCPITSFTLEYRPFGTTVWTTAQRTSL-SKSYILYDLQEATWYELQ 1547
+ W +DGG PI + +E + + +W A T + S Y L E Y +
Sbjct: 19106 DCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLVEGLEYSFR 19165
Query: 1548 MRVCNSAG 1555
+ N AG
Sbjct: 19166 IYALNKAG 19173
Score = 131 bits (329), Expect = 8e-30
Identities = 158/644 (24%), Positives = 257/644 (39%), Gaps = 61/644 (9%)
Query: 962 AKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGI--IRG 1019
AKN G ++ ++ + GP + I+ + + + W AP L +G I
Sbjct: 28033 AKNASGSAKAEIKVKVQDTPGKVVGP---IRFTNITGEKMTLWWDAP---LNDGCAPITH 28086
Query: 1020 YQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQE 1078
Y I RE S + ++ +++ YT L +Y V A N+ G G P +
Sbjct: 28087 YIIEKRETS-----RLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSD 28141
Query: 1079 IITT----TLEDVPSYP-PENVQAIATSPESISISWSTLSKEALNGILQGF------RVI 1127
+ T+ D P P P N+ SI+++W+ + + I Q +
Sbjct: 28142 PVVAQIQYTVPDAPGIPEPSNITG-----NSITLTWARPESDGGSEIQQYILERREKKST 28196
Query: 1128 YWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRS---EQIFTRT 1184
W + I ++ ++ GL + Y V+A AG G S I R
Sbjct: 28197 RWVKV-------ISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCRE 28249
Query: 1185 KEDVPGPPAGVKAAAASASMVFVSWLPPLKLNG--IIRKYTVFCSHPYPTVISEFEASPD 1242
+ PGPP VK S + V + W P+ G II C +
Sbjct: 28250 PVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACV 28309
Query: 1243 SFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEII-TVEPLAKAPARIL----TFSGTVTT 1297
Y + +L +Y V A+ AG+G+S E+ T++ + + A L F T
Sbjct: 28310 KTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVV 28369
Query: 1298 PWMKDIVLPCKAVGDPSPAVKWMK-DSNGTPSLVTIDGRRSIFSNGSFIIRTVK---AED 1353
I L G P+P W K DSN + R I + SF TV+ D
Sbjct: 28370 RAGASIRLFIAYQGRPTPTAVWSKPDSN-------LSLRADIHTTDSFSTLTVENCNRND 28422
Query: 1354 SGYYSCIANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSW-LPGDNGGSSIRG 1411
+G Y+ NN GS I ++V P P +T T S TL W P +GG+ I
Sbjct: 28423 AGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHH 28482
Query: 1412 YILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTL 1471
Y+++ E + W + + +++ +L G Y F ++A N G G E+ E
Sbjct: 28483 YVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVA 28542
Query: 1472 GKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSK 1531
++P + ++ + ++ V L +DGG IT + LE R G+ W A T
Sbjct: 28543 TEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTK-QL 28601
Query: 1532 SYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPP 1575
++ + L E T YE +++ N AG +E + F+++ I P
Sbjct: 28602 TFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEP 28645
Score = 129 bits (323), Expect = 4e-29
Identities = 282/1428 (19%), Positives = 511/1428 (35%), Gaps = 168/1428 (11%)
Query: 225 PSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKT----VTGLLI 280
P + F GQ +++ G P+P W KD +PL+ + R T +T L I
Sbjct: 23230 PDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSI 23289
Query: 281 ENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGT 340
+ D G Y V+N V+G+ + P K V + S+T
Sbjct: 23290 KETHKDDGGQYGITVAN------VVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESIT-- 23341
Query: 341 EDQELSWYRNGEILNPGKNVR--ITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYV 398
LSW N + G + I + +V + V K K +
Sbjct: 23342 ----LSW--NPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQF 23395
Query: 399 QVVLEDGTPKIISAFSEKVVS------PAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 452
++ E+ + + S+ +V+ P P + I W +P+ GGS
Sbjct: 23396 RIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQW---HEPVNNGGS 23452
Query: 453 HRISQMIT-SEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI-RPM 510
I + E N + + ++ + + D + A N + Y+ R+ + +
Sbjct: 23453 PVIGYHLERKERNSILWTKVNKTIIHDT---QFKAQNLEEGIEYEFRVYAENIVGVGKAS 23509
Query: 511 KNITAIAGRDTYIHCRVIGYPY--------YSIKWYK-----NSNLLPFNHRQVAFENNG 557
KN RD C G P +++W K S + + + +
Sbjct: 23510 KNSECYVARDP---CDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGR 23566
Query: 558 TLKLSDVQKEVDEGEYTCNVLVQPQ-----LSTSQSVHVTVKVPPFIQPF------EFPR 606
+K S V E ++T + L + Q + + K P E PR
Sbjct: 23567 WMKASFTN--VIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPR 23624
Query: 607 FSIGQRVFIPCVVVSGD------------LPITITWQKDGRPIPGSLGVTIDNIDFTSSL 654
S+ + VV +G+ LP TI W + + I S I N DF + L
Sbjct: 23625 ISMDPKFRDTIVVNAGETFRLEADVHGKPLP-TIEWLRGDKEIEESARCEIKNTDFKALL 23683
Query: 655 RISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAE 714
+ + + G Y A N A + + V P P G+ + CS
Sbjct: 23684 IVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSE----KCSLT 23739
Query: 715 GYPVPTIVWKFSKGAGVPQFQPIALNGRI---QVLSNGSLLIKHVVEEDSGYYLCKVSND 771
P V + + L + +V++N SL + ++E + + N
Sbjct: 23740 WSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTN-SLKVTKLLEGNEYVFRIMAVNK 23798
Query: 772 VGA-DVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINP 830
G + +S + +K P ++ P + T K M+ V W + D
Sbjct: 23799 YGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMT----------VCWNRPDSDGGS 23848
Query: 831 EMARYLVSTKE--------VGEEVISTLQILPT-VREDSGF-FSCHAINSYGEDRGIIQL 880
E+ Y+V ++ + I+ L++ T + ED + F A N+ G
Sbjct: 23849 EIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPAT 23908
Query: 881 T-------VQEPPDPPEIEIKDVKARTITLRWTMG-FDGNSPITGYDIE-CKNKSDSWDS 931
V +P P I D +ITL W +DG S I GY +E CK + W
Sbjct: 23909 VYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQI 23968
Query: 932 AQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEV 991
T ++ I + Y IR+ A N++G E ++ E + P ++
Sbjct: 23969 V--TPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDL 24026
Query: 992 HLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTL 1051
E +R A + H+ +G +S + + ++ + ++
Sbjct: 24027 DSELRKGIVVRAGGSA-RIHIP---FKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSI 24082
Query: 1052 DNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWST 1111
DN ++ +++ N +G S +T + D P PP+N+ +S + W
Sbjct: 24083 DNCDRNDAGKYILKLENSSG---SKSAFVTVKVLDTPG-PPQNLAVKEVRKDSAFLVWEP 24138
Query: 1112 LSKEALNGILQGFRVI--YWANLMDGELGEIKNITT--TQPSLELDGLEKYTNYSIQVLA 1167
I+ G + Y + + N+++ ++ S +++ L + Y +V+A
Sbjct: 24139 -------PIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMA 24191
Query: 1168 FTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCS 1227
G GV E + + P PP V S + + W P G V
Sbjct: 24192 ENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEM 24251
Query: 1228 HPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI--------ITVE 1279
P T A + + LS ++Y V A G+ + + +T++
Sbjct: 24252 QPKGTEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQ 24311
Query: 1280 PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIF 1339
P K P + +D+ + +G P P + W+KD ++ +
Sbjct: 24312 PSLKLPFNTYSIQAG------EDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETAT 24365
Query: 1340 SNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQP--RLTVSKTTSSSITL 1397
S I+ +D G Y+ A N+ G+ L++ V P P + + ++ + +
Sbjct: 24366 ST-VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVI 24424
Query: 1398 SWLP-GDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNG 1456
SW P GG I YI++ + + W + + + ++ LK GT Y+F + A+N
Sbjct: 24425 SWEPPAYTGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENR 24484
Query: 1457 VGPGRISEIIEAKTLGKEPQFSKE----QELFASINTTRVRLNLIGW----NDGGCPITS 1508
G S +++K + + F + SI+ ++ L+ W NDGG I
Sbjct: 24485 YGK---SAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQM---LVQWHEPVNDGGTKIIG 24538
Query: 1509 FTLEYRPFGTTVWTTAQRTSLSKS-YILYDLQEATWYELQMRVCNSAG 1555
+ LE + + +W +T + + + L E YE ++ N G
Sbjct: 24539 YHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVG 24586
Score = 128 bits (322), Expect = 5e-29
Identities = 168/786 (21%), Positives = 315/786 (40%), Gaps = 67/786 (8%)
Query: 813 GEKPIIVRWEKEDRIINPEMARYLVSTKE--------VGEEVI---STLQILPTVREDSG 861
G++ II++W K + E++ YLV +E V ++ + + L++ +
Sbjct: 29252 GKEHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDY 29311
Query: 862 FFSCHAINSYGE---DRGIIQLTVQEP---PDPPEI-EIKDVKARTITLRWTMG-FDGNS 913
F A+N+ G ++ +EP P PP + D +I+L WT +DG +
Sbjct: 29312 QFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGT 29371
Query: 914 PITGYDIECKNK-SDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS 972
I GY +E + K +D W + + T+ D+ YS R+ A N G SE S
Sbjct: 29372 DIVGYVLEMQEKDTDQWYRVHTNATI--RNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYS 29429
Query: 973 NELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGN 1032
+ E P + LE VT +A + G +S G
Sbjct: 29430 ESIA----EIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGI 29485
Query: 1033 FQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPP 1092
+ +DT+ + +D +N++ ++A N++G + + D P P
Sbjct: 29486 DLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSG---KKSATVLVKVYDTPG-PC 29541
Query: 1093 ENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITT--TQPSL 1150
+V+ S +S++I+W + + + Y + + K +TT ++
Sbjct: 29542 PSVKVKEVSRDSVTITWEIPTIDGGAPVNN-----YIVEKREAAMRAFKTVTTKCSKTLY 29596
Query: 1151 ELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWL 1210
+ GL + T Y +VL G G E +VP PA ++ + S V ++W
Sbjct: 29597 RISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWE 29656
Query: 1211 PPL-----KLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVT 1265
PL +L G + + + + V++ P + + +L+ QY + A
Sbjct: 29657 KPLYDGGSRLTGYVLEACKAGTERWMKVVT---LKPTVLEHTVTSLNEGEQYLFRIRAQN 29713
Query: 1266 SAGRGNSSE---IITVEPLAKAPARILTF--SGTVTTPWMKDIVLPCKAVGDPSPAVKWM 1320
G E +TV+ L P L+ T+ P + + L G P PA W
Sbjct: 29714 EKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWF 29773
Query: 1321 KDSN--GTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQV 1378
+ VT++ + IR D+G Y+ N G+ + + +
Sbjct: 29774 FAGSKLRESERVTVETHTKV---AKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILD 29830
Query: 1379 PPDQPR--LTVSKTTSSSITLSWLPGD-NGGSSIRGYILQYSEDNSEQWGSFPISPSERS 1435
P P + + + ++SIT+SW P + +GG+ + GY+++ + + W S + +
Sbjct: 29831 KPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRST 29890
Query: 1436 YRLENLKCGTWYKFTLTAQN--GVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVR 1493
++ L G Y F + A N G+G SE+IE ++ + P + ++F + +R
Sbjct: 29891 FKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIF---DVSRDG 29947
Query: 1494 LNLIGW---NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKS-YILYDLQEATWYELQMR 1549
+ L + +DGG +T + +E + W + ++ + Y L E YE ++
Sbjct: 29948 MTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVT 30007
Query: 1550 VCNSAG 1555
N+ G
Sbjct: 30008 AINARG 30013
Score = 127 bits (320), Expect = 8e-29
Identities = 155/701 (22%), Positives = 284/701 (40%), Gaps = 64/701 (9%)
Query: 885 PPDPPEI-EIKDVKARTITLRWTMG-FDGNSPITGYDIECKNKS-DSWDSAQRTKDVSPQ 941
PP PP ++ D +++L W+ +DG +P+ GY +E K + D W + T Q
Sbjct: 25002 PPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAADEWTTC--TPPTGLQ 25059
Query: 942 LNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDG-PPQEVHLEPISSQS 1000
T+ + ++ Y+ R+ A N G EP+ T+ A + P E+ L+ +
Sbjct: 25060 GKQFTVTKLKENTEYNFRICAINSEGVGEPA---TLPGSVVAQERIEPPEIELDADLRKV 25116
Query: 1001 IRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFT-- 1058
+ + A + I+G ++ + ++ + + +DN+ +F
Sbjct: 25117 VVLRASATLRLFVT--IKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSG 25174
Query: 1059 QYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALN 1118
+Y L ++ N +G S + + D PS P N+ +S+++SW
Sbjct: 25175 RYNLTLE--NNSG---SKTAFVNVRVLDSPS-APVNLTIREVKKDSVTLSWEP------- 25221
Query: 1119 GILQGFRVI--YWANLMDGELGEIKNITT--TQPSLELDGLEKYTNYSIQVLAFTRAGDG 1174
++ G I Y + IT T+ + ++ L++ +Y +VLA G G
Sbjct: 25222 PLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIG 25281
Query: 1175 VRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPP-----LKLNGIIRKYTVFCSHP 1229
+ +E + P PP V + + + W P K+ G + + S
Sbjct: 25282 LPAETTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEK 25341
Query: 1230 YPTV--ISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI--------ITVE 1279
+ T + EA+ I L+ +Y V AV GR + ++ I ++
Sbjct: 25342 WSTCTQVKTLEAT-------ISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIK 25394
Query: 1280 PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIF 1339
P + P TF+ V I +P K G P V W KD ++ S
Sbjct: 25395 PSVELPFH--TFN--VKAREQLKIDVPFK--GRPQATVNWRKDGQTLKETTRVNVSSSKT 25448
Query: 1340 SNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLS 1398
S I+ ED G Y +N+ GS + + + V P P + + + + SIT+S
Sbjct: 25449 VT-SLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITIS 25507
Query: 1399 WLPGD-NGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGV 1457
W P + +GG I YI++ E S W + + S ++ L G+ Y+F + A+N
Sbjct: 25508 WNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRY 25567
Query: 1458 GPGRISE--IIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRP 1515
G SE + A+ P ++ + +T + + NDGG + + LEY+
Sbjct: 25568 GKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKE 25627
Query: 1516 FGTTVWTTAQRTSLSKSYI-LYDLQEATWYELQMRVCNSAG 1555
+ +W+ A + ++ + + + L E YE ++ N AG
Sbjct: 25628 RSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAG 25668
Score = 127 bits (319), Expect = 1e-28
Identities = 151/600 (25%), Positives = 247/600 (41%), Gaps = 70/600 (11%)
Query: 972 SNELTITADEAAPDGPPQ-EVHLEPISSQSIRVTWKAPKKHLQNG--IIRGYQIGYREYS 1028
+ + IT GPP+ + + ++++ + W P LQ+G I Y I RE S
Sbjct: 24789 TKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNPP---LQDGGANISHYIIEKRETS 24845
Query: 1029 TGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDV 1087
+ + V T + Y + L +Y V A N+ G G P +T
Sbjct: 24846 -----RLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYK 24900
Query: 1088 PSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQ 1147
P PP + A + +S+ ++W+ + I +G+ ++ + + T T
Sbjct: 24901 PPGPPSTPEVSAITKDSMVVTWARPVDDGGTEI-EGY-ILEKRDKEGVRWTKCNKKTLTD 24958
Query: 1148 PSLELDGLEKYTNYSIQVLAFTRAGDGVRSE-QIFTRTKEDV--PGPPAGVKAAAASASM 1204
L + GL + +Y +V A AG G SE +F R + + PGPP+ K S S
Sbjct: 24959 LRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSS 25018
Query: 1205 VFVSWLPPLKLNGI-IRKYTVFCSHPYPTVISEFEASPDSFS------------YRIPNL 1251
V ++W P+ G ++ Y V+ EA+ D ++ + + L
Sbjct: 25019 VSLAWSKPIYDGGAPVKGY----------VVEVKEAAADEWTTCTPPTGLQGKQFTVTKL 25068
Query: 1252 SRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAV- 1310
N +Y+ + A+ S G G E T+ A RI + K +VL A
Sbjct: 25069 KENTEYNFRICAINSEGVG---EPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATL 25125
Query: 1311 -------GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSF---IIRTVKAEDSGYYSCI 1360
G P P VKW K + R I SF +I V DSG Y+
Sbjct: 25126 RLFVTIKGRPEPEVKWEKAEG------ILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLT 25179
Query: 1361 ANNNWGSDEIILNLQVQVPPDQP-RLTVSKTTSSSITLSWLPG-DNGGSSIRGYILQYSE 1418
NN GS +N++V P P LT+ + S+TLSW P +GG+ I YI++ E
Sbjct: 25180 LENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRE 25239
Query: 1419 DNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFS 1478
+ + + + ++ ++R+ENL+ G Y F + A N G G +E E + + P
Sbjct: 25240 TTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPP 25299
Query: 1479 KEQELFASINTTRVRLNLIGW----NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYI 1534
L ++ TR I W +DGG IT + +E + G+ W+T + ++ I
Sbjct: 25300 GRVTL---VDVTR-NTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATI 25355
Score = 125 bits (315), Expect = 3e-28
Identities = 155/640 (24%), Positives = 242/640 (37%), Gaps = 67/640 (10%)
Query: 953 SSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHL 1012
S T + A N +G + L + P GP + E +S+ + ++W PK
Sbjct: 16189 SDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGP---IKFESVSADQMTLSWFPPKDD- 16244
Query: 1013 QNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGT 1072
I Y I RE + + + V + YT+ L + +Y + A N+ G
Sbjct: 16245 GGSKITNYVIEKREAN-----RKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGI 16299
Query: 1073 GP--SSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWA 1130
G S+ L VP P + + T S++++W + + + YW
Sbjct: 16300 GEPLDSEPETARNLFSVPGAPDKPTVSSVTR-NSMTVNWEEPEYDGGSPVTG-----YWL 16353
Query: 1131 NLMDGELGEIKNIT-------TTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTR 1183
+ D K + T S ++ GL + ++Y +V A AG G S
Sbjct: 16354 EMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPA 16413
Query: 1184 TKEDV---PGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEAS 1240
T D PGPP K + S + W PPLK G K T + E+E
Sbjct: 16414 TARDPIAPPGPPFP-KVTDWTKSSADLEWSPPLKDGG--SKVTGYIVEYKEEGKEEWEKG 16470
Query: 1241 PDS----FSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPL------------AKA 1284
D + L Y V AV AG G E+ V + A
Sbjct: 16471 KDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASV 16530
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSF 1344
RI+ +G V I + G P P V W + P TI+ + + S
Sbjct: 16531 RDRIVVHAGGV-------IRIIAYVSGKPPPTVTWNMNERTLPQEATIE---TTAISSSM 16580
Query: 1345 IIRTVKAEDSGYYSCIANNNWGSDE---IILNLQVQVPPDQPRLTVSKTTSSSITLSWL- 1400
+I+ + G YS +A N G + I+ L V P P L T+ S L+W
Sbjct: 16581 VIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLA-HNLTNESCKLTWFS 16639
Query: 1401 PGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPG 1460
P D+GGS I Y+++ E + W + + ++ ++ L G Y F + A+N +G G
Sbjct: 16640 PEDDGGSPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMG 16699
Query: 1461 RISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN----DGGCPITSFTLEYRPF 1516
E EA + +EP E+ + + WN DGG I ++ LE R
Sbjct: 16700 PFVETSEALVI-REPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLI 16758
Query: 1517 GTTVWTTAQRTS-LSKSYILYDLQEATWYELQMRVCNSAG 1555
GT + + LS+ Y + L+E YE ++ N G
Sbjct: 16759 GTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVG 16798
Score = 125 bits (315), Expect = 3e-28
Identities = 179/833 (21%), Positives = 321/833 (38%), Gaps = 104/833 (12%)
Query: 783 TVKIPAMITSYPNTTL---------ATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMA 833
TVK+ M+ YP+ L QG ++ G+ I +W KE + I+
Sbjct: 30124 TVKVTEML-EYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISK--- 30179
Query: 834 RYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPE--I 891
R +++T E E++ I R DSG + N G+ I++ V P+ PE +
Sbjct: 30180 RAMIATSETHTELV----IKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPL 30235
Query: 892 EIKDVKARTITLRWTM-GFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDI 950
E D++ R++ + W DG + I GY +E + + +A T D + S + +
Sbjct: 30236 EYDDIQVRSVRVSWRPPADDGGADILGYILE---RREVPKAAWYTIDSRVRGTSLVVKGL 30292
Query: 951 HPSSTYSIRMYAKNRIGKSEP---SNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKA 1007
+ Y R+ A+N+ G S+P +T P+ P + ++ S+ ++W
Sbjct: 30293 KENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSR 30352
Query: 1008 PKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQAC 1067
PK + GY I +E ST + N + T+ +YT+ L +Y + A
Sbjct: 30353 PKDD-GGSRVTGYYIERKETSTDKWVRHNKTQITTT----MYTVTGLVPDAEYQFRIIAQ 30407
Query: 1068 NRAG---TGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGF 1124
N G T P+S+ ++ D PS P E ++ ++ S +S+++ W + IL
Sbjct: 30408 NDVGLSETSPASEPVVCKDPFDKPSQPGE-LEILSISKDSVTLQWEKPECDGGKEILG-- 30464
Query: 1125 RVIYWANLM---DGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAG--------- 1172
YW D + + GL + T Y +V A G
Sbjct: 30465 ---YWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAM 30521
Query: 1173 -----------DGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRK 1221
G+R E TK G A + + + W K RK
Sbjct: 30522 SIKTKLTSGEAPGIRKEMKDVTTKL---GEAAQLSCQIVGRPLPDIKWYRFGKELIQSRK 30578
Query: 1222 YTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPL 1281
Y + T+ E D Y +A G +S + ++
Sbjct: 30579 YKMSSDGRTHTLTVMTEEQEDEGVYTC-------------IATNEVGEVETSSKLLLQAT 30625
Query: 1282 AKA----PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS 1337
+ P + + +T + L +G P PA+ W + I +
Sbjct: 30626 PQFHPGYPLKEKYYGAVGST-----LRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENT 30680
Query: 1338 IFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR--LTVSKTTSSSI 1395
+ + +G Y +N +G+ + IL++++Q PD+P + + +S
Sbjct: 30681 EHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSA 30740
Query: 1396 TLSWL-PGDNGGSSIRGYILQYSE-DNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTA 1453
+SW P D+GGS I Y+++ E +W + S + R+ NL Y F ++A
Sbjct: 30741 VISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSA 30800
Query: 1454 QNGVG---PGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGW----NDGGCPI 1506
QN G P +S ++ K+ ++P + + A + V + W +DGG I
Sbjct: 30801 QNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCV----VAWKPPASDGGAKI 30856
Query: 1507 TSFTLEYRPFGTTVWTTAQRTSLSKS-YILYDLQEATWYELQMRVCNSAGCAE 1558
++ LE R W + + ++ + + +L E YE +++ N G +E
Sbjct: 30857 RNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESE 30909
Score = 124 bits (311), Expect = 9e-28
Identities = 315/1447 (21%), Positives = 538/1447 (37%), Gaps = 228/1447 (15%)
Query: 235 KAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQ----KTVTGLLIENIRPSDSGS 290
KA ++++P K G P+ W KD L+ + R KTVT L I+ D G+
Sbjct: 25407 KAREQLKIDVPFK--GRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGT 25464
Query: 291 YVCEVSNRYG------TAKVIGRLYVKQPLK--------ATISPRKVKSSVGSQVSLSCS 336
Y VSN G T V+ R P++ TIS + G Q+S +
Sbjct: 25465 YELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQIS-NYI 25523
Query: 337 VTGTEDQELSWYRNGEIL--NPGKNVRITGINHENLIMDHMVKSDGGAYQCFV----RKD 390
V E +W+ + + K VR+T G YQ V R
Sbjct: 25524 VEKKETTSTTWHIVSQAVARTSIKIVRLT---------------TGSEYQFRVCAENRYG 25568
Query: 391 KLSAQDYVQVVLE--------DGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTL 442
K S + VV E GTPK++ A K T L +TW +
Sbjct: 25569 KSSYSESSAVVAEYPFSPPGPPGTPKVVHA-----------------TKSTML--VTWQV 25609
Query: 443 DDDPILKGGSHRI---------SQMITSEGNVVSYLNISSSQVRDGGV-------YRCTA 486
P+ GGS I S ++ S+ N + I+ +Q++ G+ YR A
Sbjct: 25610 ---PVNDGGSRVIGYHLEYKERSSILWSKANKIL---IADTQMKVSGLDEGLMYEYRVYA 25663
Query: 487 NNSAGVVLYQAR---INVRGPASIRPMKNITAIAGRDTYIH---------CRVIGYPYYS 534
N AG+ + R P +T I + + ++ GY
Sbjct: 25664 ENIAGIGKCSKSCEPVPARDPCDPPGQPEVTNITRKSVSLKWSKPHYDGGAKITGY-IVE 25722
Query: 535 IKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDE--GEYTCNVLVQPQLSTSQ-SVHV 591
+ + L N+ + +L++ Q+ + + +P ST V
Sbjct: 25723 RRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKD 25782
Query: 592 TVKVPPFIQPFEFPRFSI---GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNI 648
V+ P + +F + G+ + I + LP+ I+W KDG I I +
Sbjct: 25783 DVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPV-ISWAKDGIEIEERARTEIIST 25841
Query: 649 DFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVI 708
D + L + + G Y +N A V P P + +G+ +
Sbjct: 25842 DNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCS 25901
Query: 709 LNCSAEGYPV----PTIVWKFSKGAGVPQFQPIALNGRIQVLS-NGSLLIKHVVEEDSGY 763
L+ G P I + + G +Q+ S + L+K
Sbjct: 25902 LSW---GRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLK------GNE 25952
Query: 764 YLCKVS--NDVG-ADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR 820
Y+ +V+ N G + +S+ + P + S P + T K+ M+ +
Sbjct: 25953 YIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMT----------LC 26002
Query: 821 WEKEDRIINPEMARYLVSTKE--------VGEEVISTLQILPT-VREDSGF-FSCHAINS 870
W + + E++ Y++ +E V ++ + L++ T +RE + + +A N+
Sbjct: 26003 WSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENA 26062
Query: 871 YG-----EDRGIIQL--TVQEPPDPPEIEIKDVKARTITLRWTMG-FDGNSPITGYDIEC 922
G E +I+ V P P + +I D TIT+ W FDG +PITGY +E
Sbjct: 26063 AGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEY 26122
Query: 923 KNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEA 982
K KSD D+ +T S + TI + + Y R+ + N++G S+PS+ ++D
Sbjct: 26123 K-KSD--DTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSD----SSDPQ 26175
Query: 983 APDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDT 1042
+E + S + KA RG + +S VDT
Sbjct: 26176 IAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDT 26235
Query: 1043 SGDSEVYTLDNLNK--FTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT 1100
+ T++N N+ +Y L +Q A +S ++ L D P PP N+
Sbjct: 26236 TDSRTSLTIENANRNDSGKYTLTIQNVLSA----ASLTLVVKVL-DTPG-PPTNITVQDV 26289
Query: 1101 SPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITT--TQPSLELDGLEKY 1158
+ ES +SW + + Y + ++T + S ++ L++
Sbjct: 26290 TKESAVLSWDVPENDGGAPVKN-----YHIEKREASKKAWVSVTNNCNRLSYKVTNLQEG 26344
Query: 1159 TNYSIQVLAFTRAGDGVRSEQIFTRTKEDV-----PGPPAGVKAAAASASMVFVSWLPPL 1213
Y +V G G+ +E TKE V P PP + + S V ++WL P
Sbjct: 26345 AIYYFRVSGENEFGVGIPAE-----TKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPE 26399
Query: 1214 KLNGIIRKYTVFCSHPYPTVISEFE---------ASPDSFSYRIPNLSRNRQYSVWVVAV 1264
G S V+ E A S + + L N +Y V A
Sbjct: 26400 HDGG---------SRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAE 26450
Query: 1265 TSAGRGNSSE----IITVEPLAKAPARILTF-SGTVTTPWMKDIVLPCKAVGDPSPAVKW 1319
AG + E ++ E L + F S TV ++ + G P P V
Sbjct: 26451 NQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTL 26510
Query: 1320 MKDSNGTPSLVTIDGRRSIFS-NGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQV 1378
+D G P T+ I + N + ++ D+G Y A N+ G+ + +N+ V
Sbjct: 26511 SRD--GVPLKATMRFNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLD 26568
Query: 1379 PPDQPR--LTVSKTTSSSITLSWLPGD-NGGSSIRGYILQYSEDNSEQWGSFPISPSERS 1435
P P + +S T S+TL W P +GGS + YIL E ++ W + +
Sbjct: 26569 RPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTM 26628
Query: 1436 YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFAS--INTTRVR 1493
++ L G Y+F + A+N G IS+ I++ + + ++ N TR
Sbjct: 26629 MKVMKLTTGEEYQFRIKAENRFG---ISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRES 26685
Query: 1494 LNLIGWND----GGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYI-LYDLQEATWYELQM 1548
+ +GW++ GG + + LE + + +W A + + ++ + + YE ++
Sbjct: 26686 IT-VGWHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRV 26744
Query: 1549 RVCNSAG 1555
N+AG
Sbjct: 26745 YAENAAG 26751
Score = 124 bits (310), Expect = 1e-27
Identities = 269/1172 (22%), Positives = 427/1172 (36%), Gaps = 180/1172 (15%)
Query: 417 VVSPAEPVSLMCNVKGTPLPTITWTLD--DDPILKGGSHRISQMITSEGNVVSYLNISSS 474
+V P+ L V+G P P +TW D+ + KG + M ++L I +S
Sbjct: 18617 IVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTM--------AFLVIPNS 18668
Query: 475 QVRDGGVYRCTANNSAG--VVLYQARI-NVRGPASIRPMKNITAIAGRDTYIHCRVIGYP 531
D G Y T N AG V R+ + GP S + ++T + C V P
Sbjct: 18669 TRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTS-------CHVSWAP 18721
Query: 532 YYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHV 591
EN+G +++ E E + V P++ + S HV
Sbjct: 18722 P---------------------ENDGGSQVTHYIVEKREADRKTWSTVTPEVKKT-SFHV 18759
Query: 592 TVKVPP---FIQPFEFPRFSIGQRVFIPCVVVSGDLPI-------------------TIT 629
T VP + + + G +P V++ D P+ T+
Sbjct: 18760 TNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASD-PLSEPDPPRKLEVTEMTKNSATLA 18818
Query: 630 W----QKDGRPIPGSLGVTIDNID----FTSSLRISNLSLMHNG-------NYTCIARN- 673
W + G I G + + +T + +LSL+ G + ARN
Sbjct: 18819 WLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNA 18878
Query: 674 -------EAAAV-EHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKF 725
EA V E + QL+ PPK ++ P GK + + G P PT WK
Sbjct: 18879 VGVSLPREAEGVYEAKEQLL---PPK-ILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKK 18934
Query: 726 SKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVK 785
+ V +A++ + S+ L+IK V +DSGYY N G D K +K
Sbjct: 18935 GEDEVVTSSH-LAVH---KADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQK-----IK 18985
Query: 786 IPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEV--G 843
+ M P +C+ P+ ED N + Y+V +V G
Sbjct: 18986 VVVMDAPGPPQPPFDISDIDADACSLSWHIPL------EDGGSN--ITNYIVEKCDVSRG 19037
Query: 844 EEVISTLQILPT-------VREDSGFFSCHAINSYG------EDRGIIQLTVQEPPDPPE 890
+ V + + T + F A N +G + + Q P +P
Sbjct: 19038 DWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPFGVPSEPKN 19097
Query: 891 IEIKDVKARTITLRWTM-GFDGNSPITGYDIECKNKSDS-WDSAQRTKDVSPQLNSATII 948
+ V I + W DG SPI GY IE K ++ W A T S + A ++
Sbjct: 19098 ARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRSTEYPCAGLV 19157
Query: 949 DIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAP 1008
+ YS R+YA N+ G S PS T P PP + + ++ ++ + W P
Sbjct: 19158 E---GLEYSFRIYALNKAGSSPPSKP-TEYVTARMPVDPPGKPEVIDVTKSTVSLIWARP 19213
Query: 1009 KKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACN 1068
KH I GY + G+ + E YT L + QY A
Sbjct: 19214 -KHDGGSKIIGYFV--EACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIART 19270
Query: 1069 RAGTGPSSQ--EIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRV 1126
P S+ + +T E+VP P ++ S ++ + + G +
Sbjct: 19271 AVNISPPSEPSDPVTILAENVP--PRIDLSVAMKSLLTVKAGTNVCLDATVFG--KPMPT 19326
Query: 1127 IYW---ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTR 1183
+ W L+ G + +LEL + + + + A +G +S I +
Sbjct: 19327 VSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGS--KSATIKLK 19384
Query: 1184 TKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPYPTVISEFEASPD 1242
D PGPPA VK + +SW PPL+ G I Y V ++ A+
Sbjct: 19385 VL-DKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVP 19443
Query: 1243 SFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKD 1302
S + L +Y + A G G+ + T +AK P G P + +
Sbjct: 19444 ITSCSVEKLIEGHEYQFRICAENKYGVGD--PVFTEPAIAKNP---YDPPGRCDPPVISN 19498
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSI-------FSNGSFIIRTVKA---- 1351
I V PA D G+P + +R + I RT+KA
Sbjct: 19499 ITKDHMTVSWKPPA-----DDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQ 19553
Query: 1352 EDSGY-YSCIANNNWG------SDEIILNLQVQVPPDQPRL-TVSKTTSSSITLSW-LPG 1402
E + Y + A N G + + Q PP P V TT SS++LSW P
Sbjct: 19554 EGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPA 19613
Query: 1403 DNGGSSIRGYILQYSEDNSEQW--GSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPG 1460
+GGS I GY+++ +S+ W + P + + + + L T Y+F + A N +G
Sbjct: 19614 YDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYS 19673
Query: 1461 RISEIIEAKTLGKEPQFSKEQELFASINTTRV 1492
S++ + K K+ E EL A + T +
Sbjct: 19674 DPSDVPD-KHYPKDILIPPEGELDADLRKTLI 19704
Score = 123 bits (309), Expect = 2e-27
Identities = 142/622 (22%), Positives = 247/622 (39%), Gaps = 55/622 (8%)
Query: 986 GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGD 1045
GP ++ + ++ + + W P++ I Y + RE S + N + V+
Sbjct: 29142 GPCGKLTVSRVTQEKCTLAWSLPQED-GGAEITHYIVERRETS-----RLNWVIVEGECP 29195
Query: 1046 SEVYTLDNLNKFTQYGLVVQACNRAGTGP--SSQEIITTTLEDVPSYPPENVQAIATSPE 1103
+ Y + L K +Y V+A N+ G G S+ I+ +PS PP + + T E
Sbjct: 29196 TLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPS-PPGIPEEVGTGKE 29254
Query: 1104 SISISWSTLSKEALNGILQGF------RVIYWANLMDGELGEIKNITTTQPSLELDGLEK 1157
I I W+ + N I + + W + K+ L++ L +
Sbjct: 29255 HIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVN-------KDYVVYDTRLKVTSLME 29307
Query: 1158 YTNYSIQVLAFTRAGDGVRSEQ---IFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPL- 1213
+Y +V A AG+ SE I R PGPP+ + + + ++W P+
Sbjct: 29308 GCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMY 29367
Query: 1214 ----KLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGR 1269
+ G + + + + V + A+ + + +P+L ++YS V AV G
Sbjct: 29368 DGGTDIVGYVLEMQEKDTDQWYRVHTN--ATIRNTEFTVPDLKMGQKYSFRVAAVNVKGM 29425
Query: 1270 GNSSEIIT-VEPLAKAPARILTFSG----TVTTPWMKDIVLPCKAVGDPSPAVKWMKDSN 1324
SE I +EP+ + L + TVT + L G P P + W K
Sbjct: 29426 SEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGI 29485
Query: 1325 GTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV-QVPPDQP 1383
S ID S I+ V D+G Y+ A N G + ++V P P
Sbjct: 29486 DLASRAIIDTTESY---SLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCP 29542
Query: 1384 RLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLK 1442
+ V + + S+T++W +P +GG+ + YI++ E + + S+ YR+ L
Sbjct: 29543 SVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLV 29602
Query: 1443 CGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN-- 1500
GT Y F + +N G G E +A + + P + E+ ++ T+ + L W
Sbjct: 29603 EGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEV---VDVTKSTVTL-AWEKP 29658
Query: 1501 --DGGCPITSFTLEYRPFGTTVW---TTAQRTSLSKSYILYDLQEATWYELQMRVCNSAG 1555
DGG +T + LE GT W T + T L + + L E Y ++R N G
Sbjct: 29659 LYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVL--EHTVTSLNEGEQYLFRIRAQNEKG 29716
Query: 1556 CAEKQANFATLNYDGSTIPPLI 1577
+E + + + P I
Sbjct: 29717 VSEPRETVTAVTVQDLRVLPTI 29738
Score = 122 bits (307), Expect = 3e-27
Identities = 163/714 (22%), Positives = 286/714 (40%), Gaps = 59/714 (8%)
Query: 880 LTVQEPPDPP----EIEIKDVKARTITLRWTMG-FDGNSPITGYDIEC-KNKSDSW---- 929
+ +++P DPP + +KDV ++ L WT DG + I Y IE K +D W
Sbjct: 13975 ILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVA 14034
Query: 930 DSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS--NELTITADEAAPDGP 987
+ T+ + P L YS R+ A N+ G+SEPS ++ + ++ P P
Sbjct: 14035 EGVPTTQHLLPGLMEG--------QEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSP 14086
Query: 988 PQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSE 1047
P+ + + I+ + + W P+K I Y + R+ G +Q +VDT+
Sbjct: 14087 PRWLEVINITKNTADLKWTVPEKD-GGSPITNYIVEKRDVRRKG-WQ----TVDTTVKDT 14140
Query: 1048 VYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYP--PENVQAIATSPESI 1105
T+ L + + Y V A N G ++ + +D + P P + + + +
Sbjct: 14141 KCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHV 14200
Query: 1106 SISWSTLSKEALNGILQGFRVIYWANLMDGELGE--IKNITTTQP--SLELDGLEKYTNY 1161
+ W + G + + LG +K T P + + + + T
Sbjct: 14201 DLKWEPPKNDG------GRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEV 14254
Query: 1162 SIQVLAFTRAGDGVRSEQIFTRTKEDV---PGPPAGVKAAAASASMVFVSWLPPLKLNG- 1217
QV A AG G SE + ED P PP + A + ++W PP K G
Sbjct: 14255 QFQVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGS 14314
Query: 1218 -IIRKYTVFCSHPYPTVISEFEASPDSFSYRIPN-LSRNRQYSVWVVAVTSAGRGNSSEI 1275
II + C + +++ + +++Y + V AV + G SEI
Sbjct: 14315 PIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEI 14374
Query: 1276 ----ITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVT 1331
+ +P K + T V I +P +AV P P V W KD +
Sbjct: 14375 SENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAV--PVPTVSWHKDGKEVKASDR 14432
Query: 1332 IDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV-QVPPDQPRLTVSKT 1390
+ + S + ++V+A D+G Y+ N GS +N++V +P + S
Sbjct: 14433 LTMKNDHISAHLEVPKSVRA-DAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDI 14491
Query: 1391 TSSSITLSWLPGD-NGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKF 1449
T SS L+W P + +GG+ I Y+L+ E + ++ S+ +++L Y F
Sbjct: 14492 TKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFF 14551
Query: 1450 TLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN----DGGCP 1505
+ A N VG G E ++ + ++P+ + + ++ I W DGG
Sbjct: 14552 RVKAVNKVGGGEYIE-LKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSK 14610
Query: 1506 ITSFTLEYRPFGTTVWTTAQRTSLS-KSYILYDLQEATWYELQMRVCNSAGCAE 1558
I + +E G W + +Y L+E Y+ ++R N+AG +E
Sbjct: 14611 IMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISE 14664
Score = 121 bits (303), Expect = 8e-27
Identities = 324/1591 (20%), Positives = 569/1591 (35%), Gaps = 271/1591 (17%)
Query: 126 YTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALY--- 182
+ +EDQ + AVF C + V W ++ + G ++ G+++
Sbjct: 12825 FVEHLEDQTVTEFDDAVFSCQLSREKAN----VKWYRNGREIKEGKKYKFEKDGSIHRLI 12880
Query: 183 IKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRV 242
IKD + +D Y C G + + ARLFV + I D +A V
Sbjct: 12881 IKDCRLDDEC-EYAC-------GVEDRKSRARLFVEEIP--VEIIRPPQDILEAPGADVV 12930
Query: 243 ELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LLIENIRPSDSGSYVCEVSNR 298
L L + + +WL++NM + + Q G L I +I+P D G Y ++
Sbjct: 12931 FLA--ELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDK 12988
Query: 299 YGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGK 358
AK L + K + + + VG +++ E W++ E L+ K
Sbjct: 12989 EARAK----LELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLST-K 13043
Query: 359 NVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVV 418
+ T I++ K D G Y+ ++ A+ ++ + + D V
Sbjct: 13044 TIDTTAEQTSFRILEAK-KGDKGRYKIVLQNKHGKAEGFINLKVID------------VP 13090
Query: 419 SPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRD 478
P + + G ++ W ++P+ GGS +I + ++ + ++ +
Sbjct: 13091 GPVRNLEVTETFDGEV--SLAW---EEPLTDGGS-KIIGYVVERRDIKRKTWVLATDRAE 13144
Query: 479 GGVYRCTANNSAGVVLYQARINVRGPASI-RPMKNITAIAGRDTYIHCRVIGYPY----- 532
+ T GV Y R++ R P++ + R Y V G P
Sbjct: 13145 SCEFTVTGLQKGGVE-YLFRVSARNRVGTGEPVETDNPVEARSKY---DVPGPPLNVTIT 13200
Query: 533 ------YSIKW----------YKNSNLLPFNHRQVAFENNGTLKLSDVQK---EVDEG-E 572
S+ W N + + + ++ T++ D+ +V EG E
Sbjct: 13201 DVNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQE 13260
Query: 573 YTCNVLVQPQLSTSQSVHVTVKVPPFIQ---PFEFPRFSIGQRVFIPCVVVSGDLP---I 626
Y+ V Q ++ + T PF++ P E P P + S D +
Sbjct: 13261 YSFRVRAQNRIGVGKPSAAT----PFVKVADPIERPS--------PPVNLTSSDQTQSSV 13308
Query: 627 TITWQ---KDG-RPIPGSLGVTID---------NIDFTSSLRISNLSLMHNGNYTC-IAR 672
+ W+ KDG PI G + + N+ L L Y ++
Sbjct: 13309 QLKWEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEKGNKYLYRVSA 13368
Query: 673 NEAAAVEHQSQLI--VRVPPKFVVQPRD----QDG---IYGKAVILNCSAEGYPVPTIVW 723
A V S+++ + FV D +DG I + + + GYP PT W
Sbjct: 13369 ENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATW 13428
Query: 724 KFSKGAGVPQFQPIALNGRIQVLSNGS---LLIKHVVEEDSGYYLCKVSNDVGADVSKSM 780
F + + R+++ + + L+I D G Y K+ N V
Sbjct: 13429 CFGD-------KVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKT------ 13475
Query: 781 YLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTK 840
++ +I + + P+ KE+ + + + WE D + Y+V +
Sbjct: 13476 -ISGEIDVNVIARPSAP-------KELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKR 13527
Query: 841 EVGEEVISTLQILPT---------VREDSGFFSCHAINSYGE------DRGIIQLTVQEP 885
EV + + + T V+ F A N G D + T
Sbjct: 13528 EVSRKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATV 13587
Query: 886 PDPPE-IEIKDVKARTITLRWTMGF-DGNSPITGYDIE-CKNKSDSW----DSAQRTKDV 938
PDPPE ++ +D A +I L W DG S I GY +E C SD W + TK
Sbjct: 13588 PDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDKWVACGEPVAETK-- 13645
Query: 939 SPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN---ELTITADEAAPD---------- 985
+ + Y+ R+ A NR G S+PS E+ + AP+
Sbjct: 13646 ------MEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAG 13699
Query: 986 -----GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISV 1040
G E+ ++TW L+ Q I++
Sbjct: 13700 LTVKAGTKIELPATVTGKPEPKITWTKADMILK--------------------QDKRITI 13739
Query: 1041 DTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT 1100
+ T+ + + +++A N G + ++ + D P PP
Sbjct: 13740 ENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATA---VVEVNVLDKPG-PPAAFDITDV 13795
Query: 1101 SPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTN 1160
+ ES ++W+ + + I + D E+ + T + + L
Sbjct: 13796 TNESCLLTWNPPRDDGGSKITN---YVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKE 13852
Query: 1161 YSIQVLAFTRAGDG--VRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI 1218
Y +V A G G V++ I + + D PGPP ++ + + V ++W P G
Sbjct: 13853 YIFRVAAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGS 13912
Query: 1219 -IRKYTVFCSHPYPTVISEFEASP-DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEII 1276
I Y V P P +YR+ L+ ++Y V+A AG G S+
Sbjct: 13913 PITGYWVERLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSK-- 13970
Query: 1277 TVEP-LAKAPARILTFSGTVTTPWM--KDIVLPCKAVGDPSPAVKWMKDSN--------- 1324
+ EP L K P + PW K V K VG S + W K +
Sbjct: 13971 STEPILIKDP---------IDPPWPPGKPTV---KDVGKTSVRLNWTKPEHDGGAKIESY 14018
Query: 1325 -------GTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSD-----EIIL 1372
GT V + + + + ++ ++ + N S+ + +L
Sbjct: 14019 VIEMLKTGTDEWVRV--AEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 14076
Query: 1373 NLQVQVPPDQPR-LTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPIS 1430
+ PP PR L V T ++ L W +P +GGS I YI++ + + W + +
Sbjct: 14077 CREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTT 14136
Query: 1431 PSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSK-EQELFASINT 1489
+ + L G+ Y F + A+N +G +E IE L K+ + A ++
Sbjct: 14137 VKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTE-IEDSVLAKDTFTTPGPPYALAVVDV 14195
Query: 1490 TRVRLNLIGW----NDGGCPITSFTLEYRPFGTTVWTTAQRTS-LSKSYILYDLQEATWY 1544
T+ ++L W NDGG PI + +E + T W A +T+ ++ + D+ E T
Sbjct: 14196 TKRHVDL-KWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEV 14254
Query: 1545 ELQMRVCNSAGCAEKQANFATLNYDGSTIPP 1575
+ Q+R N AG L+ + T PP
Sbjct: 14255 QFQVRAENEAGVGHPSEPTEILSIEDPTSPP 14285
Score = 120 bits (302), Expect = 1e-26
Identities = 186/844 (22%), Positives = 335/844 (39%), Gaps = 104/844 (12%)
Query: 817 IIVRWEKEDRIINPEMARYLVSTKEVGEE---VISTLQILPTVREDSGFFSCH------- 866
+ ++W+K ++ Y+V KE+ E S I+ T E +G H
Sbjct: 22455 VTLQWKKPTYDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVI 22514
Query: 867 AINSYG------EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDI 920
A N+ G E G I T ++ DPP I + TI + F ++ I G I
Sbjct: 22515 ARNAAGVFSEPSESTGAI--TARDEVDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPI 22572
Query: 921 EC----KNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELT 976
K + ++A+ + S ++ D + + + AKN G+ + +
Sbjct: 22573 PTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVK 22632
Query: 977 ITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFN 1036
+ P+GP V + ++++ + WK P + + II Y + RE S
Sbjct: 22633 VLDRPGPPEGP---VVISGVTAEKCTLAWKPPLQDGGSDIIN-YIVERRETSR------- 22681
Query: 1037 IISVDTSGDSEVYTLD----NLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYP 1091
V T D+ V TL L + +Y + A N+ G G P E + V
Sbjct: 22682 --LVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDA 22739
Query: 1092 PENVQAIATSPESISISWSTLSKEALNGILQGFRV-------IYWANLMDGELGEIKNIT 1144
P+ + + +S+ + W + + + IL G+ + I W +GE++
Sbjct: 22740 PKAPEVTTVTKDSMIVVWERPASDGGSEIL-GYVLEKRDKEGIRWTRCHKRLIGELR--- 22795
Query: 1145 TTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSE-QIFTRTKEDV--PGPPAGVKAAAAS 1201
L + GL + +Y +V A AG S + + + + PGPP K +
Sbjct: 22796 -----LRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDIT 22850
Query: 1202 ASMVFVSWLPPLKLNG------IIRKYTV------FCSHPYPTVISEFEASPDSFSYRIP 1249
S VF+SW P+ G I+ K V C+ P + + +
Sbjct: 22851 RSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPP---------TGINKTNIEVE 22901
Query: 1250 NLSRNRQYSVWVVAVTSAGRGNSSEI---ITVEPLAKAPARILTFSG----TVTTPWMKD 1302
L +Y+ + A+ AG G +++ I VE +AP L +
Sbjct: 22902 KLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLR 22961
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
+ +P K G P+P VKW K ID S S ++ V DSG Y+
Sbjct: 22962 LFVPIK--GRPTPEVKWGKVDGEIRDAAIIDVTSSFTS---LVLDNVNRYDSGKYTLTLE 23016
Query: 1363 NNWGSDEIILNLQVQVPPDQP-RLTVSKTTSSSITLSWLPGD-NGGSSIRGYILQYSEDN 1420
N+ G+ + ++V P P L V++ T S++++W P +GGS I+ YI++ E
Sbjct: 23017 NSSGTKSAFVTVRVLDTPSPPVNLKVTEITKDSVSITWEPPLLDGGSKIKNYIVEKREAT 23076
Query: 1421 SEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKE 1480
+ + + + + S++++ L+ G Y F +TA+N G G ++ + + + PQ
Sbjct: 23077 RKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQ---P 23133
Query: 1481 QELFASINTTRVRLNLIGW----NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILY 1536
+ TR ++L W +DGG I + +E + + W+ R S ++
Sbjct: 23134 PGKITVDDVTRNSVSL-SWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVK-SLQAVIT 23191
Query: 1537 DLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKML 1596
+L + Y ++ N G ++ ++ + I P +K + + + LK+
Sbjct: 23192 NLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAF-SSYSVQVGQDLKIE 23250
Query: 1597 VTIS 1600
V IS
Sbjct: 23251 VPIS 23254
Score = 119 bits (299), Expect = 2e-26
Identities = 212/1002 (21%), Positives = 366/1002 (36%), Gaps = 106/1002 (10%)
Query: 609 IGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYT 668
+G + + ++ P +TW+K+ R P + + + S L I N + G Y+
Sbjct: 17232 VGDTLRLSAIIKGVPFP-KVTWKKEDRDAPTKARIDVTPVG--SKLEIRNAAHEDGGIYS 17288
Query: 669 CIARNEAAAVEHQSQLIVRVPPKFVVQPRD-------QDGIY---------GKAVILNCS 712
N A + +++V P PRD +D Y G +VI N
Sbjct: 17289 LTVENPAGSKTVSVKVLVLDKPG---PPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYV 17345
Query: 713 AEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDV 772
E V + W P++ + + S KH+ E + + N
Sbjct: 17346 VERRDVASAQWS-----------PLSATSKKK-----SHFAKHLNEGNQYLFRVAAENQY 17389
Query: 773 GADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEM 832
G V+ P I + L G K++ + + + W K DR +
Sbjct: 17390 GRGPF------VETPKPIKALD--PLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPI 17441
Query: 833 ARYLVSTKEVGEE------VISTLQILPTVREDSGFF----SCHAINSYGEDRGIIQLTV 882
YLV +E G + ++ L+ + T + + I G I +
Sbjct: 17442 TGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIEC 17501
Query: 883 QEPPDPP--EIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSP 940
QE PP E+++K ++ + T+ F + I G + + + + +
Sbjct: 17502 QEKLVPPSVELDVKLIEGLVVKAGTTVRFP--AIIRGVPVPTAKWTTDGSEIKTDEHYTV 17559
Query: 941 QLNS----ATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPI 996
+ ++ TI + T ++ N G + LT+ P GP +++ +
Sbjct: 17560 ETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGP---INILDV 17616
Query: 997 SSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEV-YTLDNLN 1055
+ + + ++W+ PK + +I Y + ++ + V +SG S+ + +L
Sbjct: 17617 TPEHMTISWQPPKDDGGSPVIN-YIVEKQDTRK------DTWGVVSSGSSKTKLKIPHLQ 17669
Query: 1056 KFTQYGLVVQACNRAGTGPSSQEIITTTLEDV-PSYPPENVQAIATSPESISISWSTLSK 1114
K +Y V+A N+ G GP T P PP + + ++SW TL K
Sbjct: 17670 KGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSW-TLPK 17728
Query: 1115 EALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAG-- 1172
+ G+ + + G+ + + GL + Y +V A AG
Sbjct: 17729 SDGGSPITGYYME--RREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLS 17786
Query: 1173 -DGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPY 1230
S+ I PGPP K S + W PL G I Y V C P
Sbjct: 17787 KPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPG 17846
Query: 1231 PTVISEFEASP--DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI---ITVEPLAKAP 1285
+ ++R+P L +Y + A G G E+ + + + P
Sbjct: 17847 TAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPP 17906
Query: 1286 ARIL--TFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGS 1343
L T +T + I + + G P P + W K+ +D + +
Sbjct: 17907 EVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVEL 17966
Query: 1344 FIIRTVKAEDSGYYSCIANNNWG--SDEIILNLQVQVPPDQPRLTVSKTTSSSITLSW-L 1400
I V+A D G Y A N+ G I+N+ + P Q L V+ T + T+SW
Sbjct: 17967 QIKEAVRA-DHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQ-NLKVTNVTKENCTISWEN 18024
Query: 1401 PGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPG 1460
P DNGGS I +I++Y + N + W ++R + NL Y F + A+N VG G
Sbjct: 18025 PLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIK-ANLLANNEYYFRVCAENKVGVG 18083
Query: 1461 RISEIIEAKT--LGKEPQFSKEQELFASINTTRVRLNLIGWN----DGGCPITSFTLEYR 1514
IE KT L P + I + W DGG P S+ +E R
Sbjct: 18084 ---PTIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERR 18140
Query: 1515 PFGTTVWTTAQRTSLSKSYILYD-LQEATWYELQMRVCNSAG 1555
G+ W + S+ +++ + D E YE +++ N G
Sbjct: 18141 LKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGG 18182
Score = 119 bits (299), Expect = 2e-26
Identities = 211/999 (21%), Positives = 372/999 (37%), Gaps = 110/999 (11%)
Query: 618 VVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAA 677
V VSG P ITW K G + ID + S L + ++ G YT A N++
Sbjct: 29468 VSVSGRPPPVITWSKQGIDLASR--AIIDTTESYSLLIVDKVNRYDAGKYTIEAENQSG- 29524
Query: 678 VEHQSQLIVRVP------PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGV 731
+ + ++V+V P V+ +D + I G PV + + + A +
Sbjct: 29525 -KKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDG-GAPVNNYIVE-KREAAM 29581
Query: 732 PQFQPIALNG-----RIQVLSNGSLLIKHVVEEDSGYYL---CKVSNDVGADVSKSMYLT 783
F+ + RI L G++ V+ E+ Y + C+ S+ V VS+ +
Sbjct: 29582 RAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENI-YGIGEPCETSDAVL--VSEVPLVP 29638
Query: 784 VKIPAMITSYPNTTLATQ-----GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVS 838
K+ + + TLA + G + K RW K + P + + V+
Sbjct: 29639 AKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTL-KPTVLEHTVT 29697
Query: 839 TKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRG---IIQLTVQEPPDPPEIEIKD 895
+ GE+ + F A N G + +TVQ+ P I++
Sbjct: 29698 SLNEGEQYL---------------FRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLST 29742
Query: 896 VKARTITLRWTMGFDGNSPITGYDIECKN----KSDSWDSAQRTKDVSPQLNSATIIDIH 951
+ +TI + + PI G + S +S + T + ++ TI +
Sbjct: 29743 MPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETT 29802
Query: 952 PSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKH 1011
T + KN G + + ++ I P GP + ++ I + SI ++W+ P+
Sbjct: 29803 IRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP---IKIDEIDATSITISWEPPE-- 29857
Query: 1012 LQNGI-IRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRA 1070
L G + GY + R+ G + V S + L + +Y V A NR
Sbjct: 29858 LDGGAPLSGYVVEQRDAHRPG-----WLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRF 29912
Query: 1071 GTGPSSQ-EIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYW 1129
G G Q E+I PPE +Q S + ++++W + + + G+ ++
Sbjct: 29913 GIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVT-GY-IVER 29970
Query: 1130 ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRS---EQIFTRTKE 1186
+ + + T GL + Y +V A G G S + I
Sbjct: 29971 KEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPI 30030
Query: 1187 DVPGPPAGVKAAAASASMVFVSWLPP-----LKLNGIIRKYTVFCSHPY------PTVIS 1235
PG P + + + V ++W P K+ G + + H + PT I
Sbjct: 30031 APPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIR 30090
Query: 1236 EFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI---ITVEPLAKAPARILT-- 1290
E Y + +L + +Y V+A + G G +E+ + V + + P L
Sbjct: 30091 E---------YTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDER 30141
Query: 1291 FSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVK 1350
+ + I L G P P KW K+ I + + +I+
Sbjct: 30142 YQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSET---HTELVIKEAD 30198
Query: 1351 AEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR--LTVSKTTSSSITLSWLP-GDNGGS 1407
DSG Y + N G + + ++V P+ P L S+ +SW P D+GG+
Sbjct: 30199 RGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGA 30258
Query: 1408 SIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRISE 1464
I GYIL+ E W + S ++ LK Y F ++A+N G P + E
Sbjct: 30259 DILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEE 30318
Query: 1465 IIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGW----NDGGCPITSFTLEYRPFGTTV 1520
+ KT P+ + + V L+ W +DGG +T + +E + T
Sbjct: 30319 PVTPKTPLNPPEPPSNPPEVLDVTKSSVSLS---WSRPKDDGGSRVTGYYIERKETSTDK 30375
Query: 1521 WTTAQRTSLSKS-YILYDLQEATWYELQMRVCNSAGCAE 1558
W +T ++ + Y + L Y+ ++ N G +E
Sbjct: 30376 WVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSE 30414
Score = 118 bits (296), Expect = 5e-26
Identities = 160/695 (23%), Positives = 275/695 (39%), Gaps = 87/695 (12%)
Query: 928 SWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD-- 985
SW A KD+ P + T I P+S+ YA + + E TITA
Sbjct: 20412 SWSKAG--KDIRP--SDITQITSTPTSSMLTIKYATRK-----DAGEYTITATNPFGTKV 20462
Query: 986 -----------GPPQEVHLEPISSQSIRVTWKAPKKHLQNG--IIRGYQIGYREYSTGGN 1032
GPP V + +S++ +TW P L++G I+ Y + RE S
Sbjct: 20463 EHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPP---LEDGGSPIKSYILEKRETS---R 20516
Query: 1033 FQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYP 1091
+ ++S D V T L + +Y V A N G G P E + P P
Sbjct: 20517 LLWTVVSEDIQSCRHVAT--KLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGP 20574
Query: 1092 PENVQAIATSPESISISWSTLSKEALNGILQGFRV-------IYWANLMDGELGEIKNIT 1144
PE + + + ++SW + + I G+ V + W + + +++
Sbjct: 20575 PEKPEVSNVTKNTATVSWKRPVDDGGSEIT-GYHVERREKKSLRWVRAIKTPVSDLR--- 20630
Query: 1145 TTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDV---PGPPAGVKAAAAS 1201
++ GL++ + Y +V A RAG G SE + +D PGPP+ +
Sbjct: 20631 -----CKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTT 20685
Query: 1202 ASMVFVSWLPP-----LKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQ 1256
++W P L++ G + ++ + + + + +P+L +
Sbjct: 20686 KKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAW--IKDTTGTALRITQFVVPDLQTKEK 20743
Query: 1257 YSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSG------TVTTPWMKDIVLPCKAV 1310
Y+ + A+ AG G + I VE + + A V I +P K
Sbjct: 20744 YNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIK-- 20801
Query: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSF---IIRTVKAEDSGYYSCIANNNWGS 1367
G P+P V W KD+ + + R +I + SF II D+G + N G
Sbjct: 20802 GRPAPEVTWTKDN------INLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGK 20855
Query: 1368 DEIILNLQV-QVPPDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWG 1425
+N++V P L + T S+TL W LP +GGS I YI++ E + +
Sbjct: 20856 KSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYS 20915
Query: 1426 SFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFA 1485
+ + +Y++ L G Y F + A+N G G +E E + P +
Sbjct: 20916 TATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAP---SPPDSLN 20972
Query: 1486 SINTTRVRLNLIGW----NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEA 1541
++ T+ ++L W +DGG IT + +E + G+ WT T ++ +L E
Sbjct: 20973 IMDITKSTVSL-AWPKPKHDGGSKITGYVIEAQRKGSDQWTHI-TTVKGLECVVRNLTEG 21030
Query: 1542 TWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPL 1576
Y Q+ NSAG + + + + + + +P L
Sbjct: 21031 EEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPEL 21065
Score = 118 bits (295), Expect = 7e-26
Identities = 192/845 (22%), Positives = 325/845 (38%), Gaps = 134/845 (15%)
Query: 709 LNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLS---NGSLLIKHVVEEDSGYYL 765
L +G P P++ WK KG P+A + R+ V S N +L++ + D+G Y
Sbjct: 20002 LKIPIKGKPAPSVSWK--KGE-----DPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYT 20054
Query: 766 CKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKED 825
+ N G V P + T G K TA + ++W
Sbjct: 20055 ITLKNVAGTKEGTISIKVVGKPGIPT----------GPIKFDEVTAEA---MTLKWAPPK 20101
Query: 826 RIINPEMARYLVSTKE--------VGEEVISTLQILPTVREDSGF-FSCHAINSYGEDRG 876
E+ Y++ ++ V T + + E + F A N YG G
Sbjct: 20102 DDGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEG 20161
Query: 877 IIQLTV------QEPPDPPEIEIKDVKARTITLRWT-MGFDGNSPITGYDIECKNKSDS- 928
+ + P PP I DV+ +++L WT G SPITGY +E K ++
Sbjct: 20162 LKSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLL 20221
Query: 929 WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS--NELTITADEAAPDG 986
W A +T ++ + + Y R+ A N G +PS +E + D P G
Sbjct: 20222 WKRANKTPI---RMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPG 20278
Query: 987 PPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDS 1046
P+ ++ I+ S+ + W PK + + GY + R+ + + N ++V
Sbjct: 20279 KPEVIN---ITRNSVTLIWTEPK-YDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECA-- 20332
Query: 1047 EVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESIS 1106
+T+ +L + +Y ++A N AG + E T T+ Y + T + ++
Sbjct: 20333 --FTVTDLVEGGKYEFRIRAKNTAGAISAPSES-TETIICKDEYEAPTIVLDPTIKDGLT 20389
Query: 1107 I-SWSTLSKEALNGILQGFRVIYWANL-MDGELGEIKNITTTQPSLELDGLEKYTNYSIQ 1164
I + T+ A++ + + W+ D +I IT+T P+ + ++ T
Sbjct: 20390 IKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITST-PTSSMLTIKYATRKDAG 20448
Query: 1165 VLAFTRAGD-GVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI-IRKY 1222
T G + E + T DVPGPP V+ + SA ++W PPL+ G I+ Y
Sbjct: 20449 EYTITATNPFGTKVEHVKV-TVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSY 20507
Query: 1223 TV---FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVE 1279
+ S TV+SE S + L + +Y V AV G+G E
Sbjct: 20508 ILEKRETSRLLWTVVSE---DIQSCRHVATKLIQGNEYIFRVSAVNHYGKG--------E 20556
Query: 1280 PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIF 1339
P+ P +++ G P P K + SN T + T+ +R +
Sbjct: 20557 PVQSEPVKMV------------------DRFGPPGPPEK-PEVSNVTKNTATVSWKRPVD 20597
Query: 1340 SNGSFI---------------IRTVKA-------------EDSGY-YSCIANNNWG---- 1366
GS I +R +K E S Y + A N G
Sbjct: 20598 DGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPP 20657
Query: 1367 ---SDEIILNLQVQVPPDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSE 1422
SD +++ P V+ TT S +L+W P +GG I GY++++ + E
Sbjct: 20658 SEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDE 20717
Query: 1423 QWGSFPISPSER--SYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE--PQFS 1478
W + R + + +L+ Y F ++A N G G + I + + + +E P F
Sbjct: 20718 AWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFE 20777
Query: 1479 KEQEL 1483
+ EL
Sbjct: 20778 LDAEL 20782
Score = 118 bits (295), Expect = 7e-26
Identities = 306/1432 (21%), Positives = 527/1432 (36%), Gaps = 204/1432 (14%)
Query: 242 VELPCKALGHPEPDYRWLKDNMPLELSG--RFQKTVTG--LLIENIRPSDSGSYVCEVSN 297
+ELP K G P+P WLKD +PL+ S RF KT L I+N + G Y + N
Sbjct: 27583 LELPYK--GKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDN 27640
Query: 298 RYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQ---ELSWY--RNGE 352
V + P P + V LS V ED E++ Y E
Sbjct: 27641 AVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVP--EDNGGGEITCYSIEKRE 27698
Query: 353 ILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISA 412
+ + + + ++VK YQ VR + V + I++
Sbjct: 27699 TSQTNWKMVCSSVARTTFKVPNLVKD--AEYQFRVRAENRYGVSQPLV-----SSIIVAK 27751
Query: 413 FSEKVVSP-AEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITS-EGNVVSYLN 470
++ P +PV G L TW D P+ GGS + E N + +
Sbjct: 27752 HQFRIPGPPGKPVIYNVTSDGMSL---TW---DAPVYDGGSEVTGFHVEKKERNSILWQK 27805
Query: 471 ISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR----PMKNITAIA-----GRDT 521
+++S + G YR T + YQ R+ A + P K A++ G
Sbjct: 27806 VNTSPI-SGREYRATGLVEG--LDYQFRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPD 27862
Query: 522 YIHCRVIGYPYYSIKWYK-----NSNLLPF-------NHRQVAFENNGTLKLSDVQKEVD 569
YI + ++KW S ++ + N R V + +
Sbjct: 27863 YID---VTRETITLKWNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLS 27919
Query: 570 EGE-YTCNVLVQPQLST----SQSVHVTV----KVPPFIQ--PFEFPRFSI--GQRVFIP 616
G+ Y ++ + + T SQS + + VPP ++ P F I G+ + I
Sbjct: 27920 PGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIK 27979
Query: 617 CVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAA 676
+V +P +TW KDG I + + I ++ ++SL + + + H G YT A+N +
Sbjct: 27980 ALVQGRPVP-RVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASG 28038
Query: 677 AVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQP 736
+ + + ++ V+ P VV P I G+ + T+ W G
Sbjct: 28039 SAKAEIKVKVQDTPGKVVGPIRFTNITGEKM------------TLWWDAPLNDGCAPITH 28086
Query: 737 IALNGRIQVLSNGSLLIKHVVEEDSGYYLCKV--SNDVGADVSKSMYLTVKIPA----MI 790
+ R + LI+ E S Y K+ N+ VS V P ++
Sbjct: 28087 YIIEKR-ETSRLAWALIEDKCEAQS-YTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVV 28144
Query: 791 TSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKE--------- 841
T G + + T + I + W + + E+ +Y++ +E
Sbjct: 28145 AQIQYTVPDAPGIPEPSNITGNS---ITLTWARPESDGGSEIQQYILERREKKSTRWVKV 28201
Query: 842 VGEEVISTLQILPTVREDSGFFSCHAINS----YGEDRGIIQLT-VQEPPDPPE----IE 892
+ + IS + T + + H + G GI +L +EP +PP ++
Sbjct: 28202 ISKRPISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVK 28261
Query: 893 IKDVKARTITLRWTMG-FDGNSPITGYDIE-CKNKSDSWDSAQRTKDVSPQLNSATIIDI 950
+ D T++L W+ FDG I GY IE CK W V + T+ D+
Sbjct: 28262 VTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACVKTRY---TVTDL 28318
Query: 951 HPSSTYSIRMYAKNRIGKSEPSNELT--------ITADEAAPDGPPQEVHLEPISSQSIR 1002
Y R+ A N GK + S E+T +TA E D ++ H+ + SIR
Sbjct: 28319 QAGEEYKFRVSAINGAGKGD-SCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGA-SIR 28376
Query: 1003 VTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGL 1062
+ I Y+ T ++ + S ++++T D+ + T
Sbjct: 28377 LF-----------------IAYQGRPTP-TAVWSKPDSNLSLRADIHTTDSFSTLT---- 28414
Query: 1063 VVQACNRAGTGP--------SSQEIITTTLE--DVPSYPPENVQAIATSPESISISWSTL 1112
V+ CNR G S + IT T++ D P PP + + S ++ W
Sbjct: 28415 -VENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPG-PPGPITFKDVTRGSATLMWDA- 28471
Query: 1113 SKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAG 1172
L+G + + ++ + T+ +++ L + Y +V A G
Sbjct: 28472 --PLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYG 28529
Query: 1173 DGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPYP 1231
G E + P PP + S S ++WL P G I Y +
Sbjct: 28530 VGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGS 28589
Query: 1232 TVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAG----RGNSSEIITVEPLAKAPAR 1287
E ++ + L +Y V A AG R S +I EP + A
Sbjct: 28590 DFWVE-AGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEPTAD 28648
Query: 1288 ILTFSGTVTT-----PWMKDIVLPCKAVGDPSPAVKW------MKDSNGTPSLVTIDGRR 1336
+ + + T P+ D+ + G P+P V W +K+++ S+ T R
Sbjct: 28649 LTGITNQLITCKAGSPFTIDVPIS----GRPAPKVTWKLEEMRLKETDRV-SITTTKDRT 28703
Query: 1337 SIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV--QVPPDQPRLTVSKTTSSS 1394
++ ++ DSG Y N G + + V + P + VS ++ S
Sbjct: 28704 TL------TVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSAES 28757
Query: 1395 ITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTA 1453
LSW P D GG+ I YI++ E + W S ++ +L Y F +++
Sbjct: 28758 CVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRVSS 28817
Query: 1454 QNGVGPGRISEIIEAKTLGKEPQF------SKEQELFASINTTRVRLNLIGWNDGGCPIT 1507
+N G +S+ +E+ + E F ++ + S N +R ++DGG I
Sbjct: 28818 ENRFG---VSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWE-EPYHDGGSKII 28873
Query: 1508 SFTLEYRPFGTTVWTTAQRT-SLSKSYILYDLQEATWYELQMRVCNSAGCAE 1558
+ +E + T +W + L +Y + L E Y+ + N+AG ++
Sbjct: 28874 GYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSK 28925
Score = 117 bits (293), Expect = 1e-25
Identities = 170/751 (22%), Positives = 289/751 (38%), Gaps = 73/751 (9%)
Query: 847 ISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPE--IEIKDVKARTITLR 904
++ L I T D+G ++ N G I++ + + P PP I+I ++ A +IT+
Sbjct: 29793 VAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITIS 29852
Query: 905 WTMG-FDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAK 963
W DG +P++GY +E + D+ S ++ + + Y R+ A
Sbjct: 29853 WEPPELDGGAPLSGYVVE---QRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAAT 29909
Query: 964 NRIG-KSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQI 1022
NR G S +E+ GPP+ + + +S + +TW P+ + GY +
Sbjct: 29910 NRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDD-GGSQVTGYIV 29968
Query: 1023 GYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITT 1082
+E + N + V + Y L + +Y V A N G+G S+
Sbjct: 29969 ERKEVRADRWVRVNKVPVTMTR----YRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPI 30024
Query: 1083 TLED--VPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVI-YWANLMDGELGE 1139
D P P+N + T+ S+S++WS E G +V Y + + E
Sbjct: 30025 VAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEG------GSKVTGYLIEMQKVDQHE 30078
Query: 1140 IKNITTTQPSLE---LDGLEKYTNYSIQVLAFTRAGDGVRSEQIFT-RTKEDVPGPPAGV 1195
TT + L L + Y +VLA G G +E T + E + P +
Sbjct: 30079 WTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYEL 30138
Query: 1196 KAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNR 1255
V + G+IR P+P I ++ S R ++ +
Sbjct: 30139 DERYQEGIFV--------RQGGVIRLTIPIKGKPFP--ICKWTKEGQDISKRAM-IATSE 30187
Query: 1256 QYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSP 1315
++ V+ G + +++ K I + +P + L + S
Sbjct: 30188 THTELVIKEADRGDSGTYDLVLENKCGKKAVYIKV--RVIGSPNSPEGPLEYDDIQVRSV 30245
Query: 1316 AVKWMK--DSNGTPSLVTIDGRRSI-----------FSNGSFIIRTVKAEDSGYYSCIAN 1362
V W D G L I RR + S +++ +K ++ A
Sbjct: 30246 RVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAE 30305
Query: 1363 NNWG------SDEIILNLQVQVPPDQPRLT--VSKTTSSSITLSWL-PGDNGGSSIRGYI 1413
N +G S+E + PP+ P V T SS++LSW P D+GGS + GY
Sbjct: 30306 NQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYY 30365
Query: 1414 LQYSEDNSEQWGSFPISP-SERSYRLENLKCGTWYKFTLTAQNGVGPGRIS---EIIEAK 1469
++ E ++++W + + Y + L Y+F + AQN VG S E + K
Sbjct: 30366 IERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCK 30425
Query: 1470 TLGKEPQFSKEQELFASINTTRVRLNLIGWN----DGGCPITSFTLEYRPFGTTVWTTAQ 1525
+P E E+ SI+ V L W DGG I + +EYR G + W +
Sbjct: 30426 DPFDKPSQPGELEIL-SISKDSVTLQ---WEKPECDGGKEILGYWVEYRQSGDSAWKKSN 30481
Query: 1526 RTSL-SKSYILYDLQEATWYELQMRVCNSAG 1555
+ + K + + L EAT YE ++ N G
Sbjct: 30482 KERIKDKQFTIGGLLEATEYEFRVFAENETG 30512
Score = 114 bits (285), Expect = 1e-24
Identities = 164/737 (22%), Positives = 281/737 (38%), Gaps = 54/737 (7%)
Query: 772 VGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPE 831
V + ++L VK+ A +T G K E+ T G+ + W K D I+ +
Sbjct: 13682 VDTQEAPEIFLDVKLLAGLT-------VKAGTKIELPATVTGKPEPKITWTKADMILKQD 13734
Query: 832 MARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP-E 890
++ + V ++ ST+ I+ + R D+G + A+N G ++++ V + P PP
Sbjct: 13735 KR---ITIENVPKK--STVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGPPAA 13789
Query: 891 IEIKDVKARTITLRWT-MGFDGNSPITGYDIECK-NKSDSWDSAQRT-KDVSPQLNSATI 947
+I DV + L W DG S IT Y +E + S+ W T KD + +
Sbjct: 13790 FDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKLSSTVKDTNFKATK--- 13846
Query: 948 IDIHPSSTYSIRMYAKNRIGKSEPSNELTITAD-EAAPDGPPQEVHLEPISSQSIRVTWK 1006
+ P+ Y R+ A+N G EP ITA + P GPP + I+ ++ +TW
Sbjct: 13847 --LIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWC 13904
Query: 1007 APKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQA 1066
P I GY + + T + N + V + Y + L +Y V A
Sbjct: 13905 EPDDD-GGSPITGYWVERLDPDTDKWVRCNKMPVKDT----TYRVKGLTNKKKYRFRVLA 13959
Query: 1067 CNRAGTGPSSQEIITTTLEDV--PSYPPENVQAIATSPESISISWSTLSKEALNGILQGF 1124
N AG G S+ ++D P +PP S+ ++W+ + ++ +
Sbjct: 13960 ENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDVGKTSVRLNWTKPEHDG-GAKIESY 14018
Query: 1125 RVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSE---QIF 1181
+ D + + + TTQ L GL + YS +V A +AG+ SE +
Sbjct: 14019 VIEMLKTGTDEWVRVAEGVPTTQHL--LPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVL 14076
Query: 1182 TRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPYPTVISEFEAS 1240
R K P PP ++ + + + W P K G I Y V + +
Sbjct: 14077 CREKLYPPSPPRWLEVINITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTT 14136
Query: 1241 PDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI---ITVEPLAKAPARILTFSGTVTT 1297
+ L+ Y V A + G+ + +EI + + P + T
Sbjct: 14137 VKDTKCTVTPLTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVT 14196
Query: 1298 PWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYY 1357
D+ P +++ + + ++ + +F + V +
Sbjct: 14197 KRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQF 14256
Query: 1358 SCIANNNWG-----SDEIILNLQVQVPPDQPRLTVSKTTS--SSITLSWLPGD-NGGSSI 1409
A N G IL+++ P P L + T + I ++W P + NGGS I
Sbjct: 14257 QVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPI 14316
Query: 1410 RGYILQYSEDNSEQW---GSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
GY ++ +E+W S PI + E + Y + A N +G P IS
Sbjct: 14317 IGYHVEMCPVGTEKWMRVNSRPIKDLKFKVE-EGVVPDKEYVLRVRAVNAIGVSEPSEIS 14375
Query: 1464 EIIEAKTLGKEPQFSKE 1480
E + AK +P E
Sbjct: 14376 ENVVAKDPDCKPTIDLE 14392
Score = 112 bits (280), Expect = 4e-24
Identities = 159/711 (22%), Positives = 279/711 (39%), Gaps = 76/711 (10%)
Query: 884 EPPDPP-EIEIKDVKARTITLRWTMG-FDGNSPITGYDIECKN-KSDSWDSAQRTKDVSP 940
+PP PP +I I D +ITL W+ +DG S +TGY +E + + + W + +V
Sbjct: 27165 DPPGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEV-- 27222
Query: 941 QLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN------------------ELTITADEA 982
+ + ++ P Y R+ A N G+ EP ++ +
Sbjct: 27223 RTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVI 27282
Query: 983 APDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDT 1042
A G +V + VTW+ +K+L G + +++I + D+
Sbjct: 27283 AKAGEDVQVLIPFKGRPPPTVTWRKDEKNL-----------------GSDARYSIENTDS 27325
Query: 1043 SGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSP 1102
S + + N +Y L ++ G G ++ + D P+ + +Q S
Sbjct: 27326 SSLLTIPQVTR-NDTGKYILTIEN----GVGEPKSSTVSVKVLDTPA-ACQKLQVKHVSR 27379
Query: 1103 ESISISWSTLSKEALNGILQGFRVIYWANLMDG--ELGEIKNITTTQPSLELDGLEKYTN 1160
++++ W + + I+ Y D + + + S +L L + T
Sbjct: 27380 GTVTLLWDPPLIDGGSPIIN-----YVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTP 27434
Query: 1161 YSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNG-II 1219
+ +VLA G G E +VP P + ++ + V +SW P G +I
Sbjct: 27435 FFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVI 27494
Query: 1220 RKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI--IT 1277
+Y V S S + + L V A G + I IT
Sbjct: 27495 TEYVVERKGKGEQTWSHAGISK-TCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPIT 27553
Query: 1278 VEPLAKAPARILTF--SGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGR 1335
V+ L P L+ VT ++ L G P P++ W+KD G P + R
Sbjct: 27554 VKELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKD--GLPLKESEFVR 27611
Query: 1336 RSIFSNG-SFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR--LTVSKTTS 1392
S N + I+ K E G Y+ I +N + + + PP +P+ + + +
Sbjct: 27612 FSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGPIRFDEIKA 27671
Query: 1393 SSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTL 1451
S+ LSW +P DNGG I Y ++ E + W S + ++++ NL Y+F +
Sbjct: 27672 DSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRV 27731
Query: 1452 TAQN--GVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN----DGGCP 1505
A+N GV +S II AK + P + ++ N T ++L W+ DGG
Sbjct: 27732 RAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY---NVTSDGMSLT-WDAPVYDGGSE 27787
Query: 1506 ITSFTLEYRPFGTTVWTTAQRTSLS-KSYILYDLQEATWYELQMRVCNSAG 1555
+T F +E + + +W + +S + Y L E Y+ ++ NSAG
Sbjct: 27788 VTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAG 27838
Score = 112 bits (279), Expect = 5e-24
Identities = 278/1282 (21%), Positives = 462/1282 (36%), Gaps = 207/1282 (16%)
Query: 404 DGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEG 463
D P I + +V E +S+ + P+PT++W D G + S +T +
Sbjct: 14384 DCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKD------GKEVKASDRLTMKN 14437
Query: 464 NVVS-YLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTY 522
+ +S +L + S D G+Y T N G A INV+ P K+I A T
Sbjct: 14438 DHISAHLEVPKSVRADAGIYTITLENKLGSAT--ASINVKVIGLPGPCKDIKA--SDITK 14493
Query: 523 IHCRVIGYPYYSIKWYKNSNLLPF-------NHRQVAFENNGTLKLSDVQKE-VDEGEYT 574
C++ P ++ + +L + R +G KLS K+ + GEY
Sbjct: 14494 SSCKLTWEPP---EFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYF 14550
Query: 575 CNVLVQPQLSTSQSVHVTVKVPPFIQ-PFEFPRFSIGQRVFIPCVVVSGDLPITITWQKD 633
V ++ + ++ +K P Q P + P + V P +TITW+
Sbjct: 14551 FRVKAVNKVGGGE--YIELKNPVIAQDPKQPPDPPVDVEVHNPTAEA-----MTITWKPP 14603
Query: 634 ----GRPIPGSLGVTID---------NIDFTSSLRISNLSLMHNGNYTCIARNE-AAAVE 679
G I G + I N L + L Y R E AA +
Sbjct: 14604 LYDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGIS 14663
Query: 680 HQSQLIVRVPPKFVVQPRDQDGIY---------GKAVILNCSAEGYPVPTIVWKFSKGAG 730
S+ PP V P D + G + L+ S G P PTI W +
Sbjct: 14664 EPSRA---TPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPTITWIKDENVI 14720
Query: 731 VPQF-------------------QP--IALNGRIQVLSN----GSLLIKHVVEEDSGYYL 765
VP+ +P + L R+ + ++ L ++ + D G Y+
Sbjct: 14721 VPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLRVRDSLRPDHGLYM 14780
Query: 766 CKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKED 825
KV ND G K P ++ L T G + ++ +WE
Sbjct: 14781 IKVENDHGI---------AKAPCTVS-----VLDTPGPPINFVFEDIRKTSVLCKWEPPL 14826
Query: 826 RIINPEMARYLVSTKEVGEE------VISTLQ-----ILPTVREDSGFFSCHAINSYGED 874
E+ Y + K+ + V STL+ + + F A N +G
Sbjct: 14827 DDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPG 14886
Query: 875 RGIIQ--LTVQEPPDPPEIE----IKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDS 928
+ L ++P PP+ ++DV + ++ ++W D SPI GY +E K + +S
Sbjct: 14887 PPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSPILGYWLE-KREVNS 14945
Query: 929 WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRI--GKSEPSNELTITADEAAPDG 986
++ K + L A + + TY R+ A+N GK P ++ D +P G
Sbjct: 14946 THWSRVNKSLLNAL-KANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPG 15004
Query: 987 PPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGY-----QIGYREYSTGGNFQFNIISVD 1041
PP + SS +I + W+ P + G I GY +G E+S +
Sbjct: 15005 PPIP-RVTDTSSTTIELEWEPPAFN-GGGEIVGYFVDKQLVGTNEWSRCTEKMIKV---- 15058
Query: 1042 TSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATS 1101
YT+ + + Y L V A N AG GP + T E P PP ++
Sbjct: 15059 -----RQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAE--PQEPPAVELDVSVK 15111
Query: 1102 PESISISWSTLSKEALNGILQGFRV--IYWANLMDGELGE----IKNITTTQPSLELDGL 1155
++ TL + ++ G V W +GEL + I N+ T + D L
Sbjct: 15112 GGIQIMAGKTL---RIPAVVTGRPVPTKVWTK-EEGELDKDRVVIDNVGTKSELIIKDAL 15167
Query: 1156 EK-YTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPP-- 1212
K + Y I + ++F DVPGP +K + M ++W P
Sbjct: 15168 RKDHGRYVITATNSCGSKFAAARVEVF-----DVPGPVLDLKPVVTNRKMCLLNWSDPED 15222
Query: 1213 ---LKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGR 1269
++ G I + H + I + D I L ++Y V+A G
Sbjct: 15223 DGGSEITGFIIERKDAKMHTWRQPIETERSKCD-----ITGLLEGQEYKFRVIAKNKFGC 15277
Query: 1270 GNSSE---IITVEPLA--KAPARILTFS----GTVTTPWMKDIVLPCKAVGDPSPAVKWM 1320
G E I+ V+PL +P R LT++ T+T W + P G P
Sbjct: 15278 GPPVEIGPILAVDPLGPPTSPER-LTYTERTKSTITLDWKE----PRSNGGSPIQGYIIE 15332
Query: 1321 KDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV---- 1376
K + P ++ R + SF++ + + A N G E L L V
Sbjct: 15333 KRRHDKPDFERVNKR--LCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQD 15390
Query: 1377 -QVPP----------DQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWG 1425
+VPP D ++ + ++ LP S +++ D + Q
Sbjct: 15391 DEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTD-ALQIT 15449
Query: 1426 SFPISPSERSYRLENLKCGTWYK--FTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQEL 1483
+S SE L K K +T+TA N +G + +E P+
Sbjct: 15450 KEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPR------- 15502
Query: 1484 FASINTTRVRLNLIGW----NDGGCPITSFTLEYRPFG--TTVWTTAQRTSLSKSYILYD 1537
++ + + W ++GG IT + ++ R W T++ K Y ++
Sbjct: 15503 NLAVTDIKAESCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWK 15562
Query: 1538 LQEATWYELQMRVCNSAGCAEK 1559
L YE ++R N G +++
Sbjct: 15563 LIPNGQYEFRVRAVNKYGISDE 15584
Score = 111 bits (277), Expect = 8e-24
Identities = 187/861 (21%), Positives = 328/861 (38%), Gaps = 140/861 (16%)
Query: 782 LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKE 841
L+V + +++T T + + T G+ V W+K+ ++ P K
Sbjct: 19297 LSVAMKSLLTVKAGTNVC-------LDATVFGKPMPTVSWKKDGTLLKPAEG-----IKM 19344
Query: 842 VGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKART 900
+ + TL++ R+DSG ++ A NS G I+L V + P PP ++I + +
Sbjct: 19345 AMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDR 19404
Query: 901 ITLRWTMGF-DGNSPITGYDIECKNKS-DSWDSAQRTKDVSPQLNSATIIDIHPSSTYSI 958
L W DG S IT Y ++ + S +W T ++ S ++ + Y
Sbjct: 19405 AMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPIT----SCSVEKLIEGHEYQF 19460
Query: 959 RMYAKNRIGKSEP-SNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGII 1017
R+ A+N+ G +P E I + P G + I+ + V+WK P I
Sbjct: 19461 RICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPVISNITKDHMTVSWKPPADD-GGSPI 19519
Query: 1018 RGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ 1077
GY + RE + N + L + T+Y V A N+AG G S
Sbjct: 19520 TGYLLEKRETQAVNWTKVNRKPI----IERTLKATGLQEGTEYEFRVTAINKAGPGKPSD 19575
Query: 1078 EIITTTLED--VPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDG 1135
D P PP + T+ S+S+SW K A +G G +I G
Sbjct: 19576 ASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSW---GKPAYDG---GSPII-------G 19622
Query: 1136 ELGEIKNITT------------TQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTR 1183
L E+K + + E+ GL + T Y +V A + G S+
Sbjct: 19623 YLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKH 19682
Query: 1184 TKEDVPGPPAG-----------VKAAAASASMVFVSWLPPLKLN------------GIIR 1220
+D+ PP G ++A V V PP K+ G+
Sbjct: 19683 YPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDI 19742
Query: 1221 KYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEP 1280
K T F + +++++A + + N ++Y++ V + + G + +TV+
Sbjct: 19743 KSTDFDTFLRCENVNKYDAG--KYILTLENSCGKKEYTIVVKVLDTPGPPVN---VTVKE 19797
Query: 1281 LAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTP----SLVTIDGRR 1336
++K A + W I + SP + ++ S VT +
Sbjct: 19798 ISKDSAYV---------TWEPPI------IDGGSPIINYVVQKRDAERKSWSTVTTE--- 19839
Query: 1337 SIFSNGSFIIRTVKAEDSGYYSCIANNNWG-------SDEIILNLQVQVPPDQPRLTVSK 1389
S SF + ++ S ++ A N +G D + + Q P L V
Sbjct: 19840 --CSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKAS---QTPGPVVDLKVRS 19894
Query: 1390 TTSSSITLSW-LPGDNGGSSIRGYILQY-SEDNSEQWGSFPISPSERSYRLENLKCGTWY 1447
+ SS ++ W P +GGS I GY++ + +E+N Q +S Y ++L G Y
Sbjct: 19895 VSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLS---LQYSAKDLTEGKEY 19951
Query: 1448 KFTLTAQNGVGPGRISEI------------IEAKTLGKEPQFSKEQELFASINTTRVRLN 1495
F ++A+N G G SEI ++ K L +KE F R+++
Sbjct: 19952 TFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNF------RLKIP 20005
Query: 1496 LIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAG 1555
+ G P S+ P T + + ++++ + I+YD Q++ + + + N AG
Sbjct: 20006 IKG---KPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAG 20062
Query: 1556 CAEKQANFATLNYDGSTIPPL 1576
E + + G P+
Sbjct: 20063 TKEGTISIKVVGKPGIPTGPI 20083
Score = 110 bits (274), Expect = 2e-23
Identities = 159/676 (23%), Positives = 273/676 (40%), Gaps = 73/676 (10%)
Query: 829 NPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDP 888
N E Y ++ + TL I + R D+G ++ A+N+ G ++L V P P
Sbjct: 16160 NKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGP 16219
Query: 889 P--EIEIKDVKARTITLRW-TMGFDGNSPITGYDIECKNKS-DSWDSAQRTKDVSPQLNS 944
P I+ + V A +TL W DG S IT Y IE + + +W P+ +
Sbjct: 16220 PVGPIKFESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSS----EPKECT 16275
Query: 945 ATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEA-APDGPPQEVHLEPISSQSIRV 1003
TI + Y R+ A+N+ G EP + TA + G P + + ++ S+ V
Sbjct: 16276 YTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTRNSMTV 16335
Query: 1004 TWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLV 1063
W+ P ++ + GY + ++ ++ + N + Y + L + + Y
Sbjct: 16336 NWEEP-EYDGGSPVTGYWLEMKDTTSKRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFR 16394
Query: 1064 VQACNRAGTGPSSQEIITTTLEDVPSYP-PENVQAIATSPESISISWSTLSKEALNGILQ 1122
V A N AG GP+S T D + P P + + S + WS K+ +
Sbjct: 16395 VYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTDWTKSSADLEWSPPLKDG-GSKVT 16453
Query: 1123 GFRVIY-WANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQI- 1180
G+ V Y + E G+ K + T+ L + GL++ Y +V A AG G E
Sbjct: 16454 GYIVEYKEEGKEEWEKGKDKEVRGTK--LVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTD 16511
Query: 1181 FTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVI------ 1234
K+ + P + A+ +V G+IR P PTV
Sbjct: 16512 VIEMKDRLVSPDLQLDASVRDRIVVHA--------GGVIRIIAYVSGKPPPTVTWNMNER 16563
Query: 1235 -----SEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARIL 1289
+ E + S S I N R+ Q ++A AG + I+ V L
Sbjct: 16564 TLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVDV----------L 16613
Query: 1290 TFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM--KDSNGTP-SLVTIDGRRSIFSNGSFII 1346
G V TP++ + + S + W +D G+P + I+ R S + +
Sbjct: 16614 DVPGPVGTPFL------AHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWTPVT 16667
Query: 1347 RTVKAEDSG----------YYSCIANNNWG-------SDEIILNLQVQVPPDQPRLTVSK 1389
TV +++ ++ A N+ G S+ +++ + VP L V +
Sbjct: 16668 YTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKE 16727
Query: 1390 TTSSSITLSWLPGD-NGGSSIRGYILQYSEDNSEQWGSFP-ISPSERSYRLENLKCGTWY 1447
T +++TL+W P +GGS I Y+L+ +E++ + R Y ++ LK G Y
Sbjct: 16728 VTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTY 16787
Query: 1448 KFTLTAQNGVGPGRIS 1463
++ ++A N VG G+ S
Sbjct: 16788 EYRVSAVNIVGQGKPS 16803
Score = 109 bits (272), Expect = 3e-23
Identities = 171/787 (21%), Positives = 310/787 (39%), Gaps = 71/787 (9%)
Query: 815 KPIIVRWEKEDRIINPEMARYLVSTKE-------------VGEEVISTLQILPTVREDSG 861
K + ++W K ++ Y+V +E + E ++ R +
Sbjct: 25699 KSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFR 25758
Query: 862 FFSCHAINSYGE-DRGIIQLTVQEPPDPPEIEIKDVKAR-TITLRWTMGFDGNSPITGYD 919
F+ +A +S E + V++ +PP + + DVK R I ++ N+ I G
Sbjct: 25759 VFARNAADSVSEPSESTGPIIVKDDVEPPRV-MMDVKFRDVIVVKAGEVLKINADIAGRP 25817
Query: 920 ---IECKNKSDSWDSAQRTKDVSPQLNSA-TIIDIHPSSTYSIRMYAKNRIGKSEPSNEL 975
I + RT+ +S ++ T+ D T + KN G +
Sbjct: 25818 LPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNC 25877
Query: 976 TITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQF 1035
+ P GP + + ++++ ++W P++ I Y + RE S + +
Sbjct: 25878 KVLDKPGPPAGP---LEINGLTAEKCSLSWGRPQED-GGADIDYYIVEKRETS---HLAW 25930
Query: 1036 NIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLED--VPSYPPE 1093
I + S T L K +Y V N+ G G + + L+ VPS PP
Sbjct: 25931 TICEGELQMTSCKVT--KLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPS-PPT 25987
Query: 1094 NVQAIATSPESISISWSTLSKEALNGILQGFRV-------IYWANLMDGELGEIKNITTT 1146
+++ + + ES+++ WS + + I G+ + + W + + +++ +T
Sbjct: 25988 SLEITSVTKESMTLCWSRPESDGGSEI-SGYIIERREKNSLRWVRVNKKPVYDLRVKST- 26045
Query: 1147 QPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKED---VPGPPAGVKAAAASAS 1203
GL + Y +V A AG + SE ED +P PP+ K + +
Sbjct: 26046 -------GLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKT 26098
Query: 1204 MVFVSWLPPLKLNGI-IRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVV 1262
+ ++W+ PL G I YTV T S Y I L+ +Y V
Sbjct: 26099 TITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVK 26158
Query: 1263 AVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAV--------GDPS 1314
+V G + S+ + +AK F + + K +++ A G P
Sbjct: 26159 SVNKVGASDPSDSSDPQ-IAKEREEEPLFD--IDSEMRKTLIVKAGASFTMTVPFRGRPV 26215
Query: 1315 PAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNL 1374
P V W K + +D + S S I DSG Y+ N + + L +
Sbjct: 26216 PNVLWSKPDTDLRTRAYVD---TTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVV 26272
Query: 1375 QVQVPPDQP-RLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPS 1432
+V P P +TV T S LSW +P ++GG+ ++ Y ++ E + + W S + +
Sbjct: 26273 KVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCN 26332
Query: 1433 ERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRV 1492
SY++ NL+ G Y F ++ +N G G +E E + ++P E+ SI+ V
Sbjct: 26333 RLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPS-PPEKLGVTSISKDSV 26391
Query: 1493 RLN-LIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVC 1551
L L +DGG I + +E G W + S +++ L+E + Y ++
Sbjct: 26392 SLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKC-AVAKSTHHVVSGLRENSEYFFRVFAE 26450
Query: 1552 NSAGCAE 1558
N AG ++
Sbjct: 26451 NQAGLSD 26457
Score = 106 bits (265), Expect = 2e-22
Identities = 137/642 (21%), Positives = 260/642 (40%), Gaps = 54/642 (8%)
Query: 986 GPPQ-EVHLEPISSQSIRVTWKAPKKHLQNG--IIRGYQIGYREYSTGGNFQFNIISVDT 1042
GPP+ V + ++S+ +TW P LQ+G I Y + RE S + +++ +
Sbjct: 23720 GPPEGPVQVTGVTSEKCSLTWSPP---LQDGGSDISHYVVEKRETS---RLAWTVVASEV 23773
Query: 1043 SGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQAIATS 1101
+S T L + +Y + A N+ G G P + V PP++++ +
Sbjct: 23774 VTNSLKVT--KLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIA 23831
Query: 1102 PESISISWSTLSKEALNGILQGFRV-------IYWANLMDGELGEIKNITTTQPSLELDG 1154
+S+++ W+ + + I+ G+ V I W + +++ L + G
Sbjct: 23832 KDSMTVCWNRPDSDGGSEII-GYIVEKRDRSGIRWIKCNKRRITDLR--------LRVTG 23882
Query: 1155 LEKYTNYSIQVLAFTRAGDGVRSEQ-IFTRTKEDV--PGPPAGVKAAAASASMVFVSWLP 1211
L + Y +V A AG G S ++ + + V PGPP + + + ++W
Sbjct: 23883 LTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGK 23942
Query: 1212 PLKLNG--IIRKYTVFCS---HPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTS 1266
P+ G I+ C + V + F I L+ +++Y + V A+
Sbjct: 23943 PIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFE--ISKLTEHQEYKIRVCALNK 24000
Query: 1267 AGRGNSSEII-TVEPLAKAPARILTFSG------TVTTPWMKDIVLPCKAVGDPSPAVKW 1319
G G ++ + TV+P K A L V I +P K G P+P + W
Sbjct: 24001 VGLGEATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFK--GRPTPEITW 24058
Query: 1320 MKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVP 1379
++ V I+ + I D+G Y N+ GS + ++V
Sbjct: 24059 SREEGEFTDKVQIEKG---VNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDT 24115
Query: 1380 PDQPR-LTVSKTTSSSITLSWLPGD-NGGSSIRGYILQYSEDNSEQWGSFPISPSERSYR 1437
P P+ L V + S L W P +GG+ ++ Y++ E + + + S+ S++
Sbjct: 24116 PGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFK 24175
Query: 1438 LENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLI 1497
+ENL G Y F + A+N G G E ++A + P + L T+ +
Sbjct: 24176 VENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEK 24235
Query: 1498 GWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCA 1557
+DGG + + +E +P GT W+ + + + ++ L Y+ +++ N G +
Sbjct: 24236 PEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNA-VVTGLSSGQEYQFRVKAYNEKGKS 24294
Query: 1558 EKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLVTI 1599
+ + + TI P +K + N + E LK+ + +
Sbjct: 24295 DPRVLGVPVIAKDLTIQPSLK-LPFNTYSIQAGEDLKIEIPV 24335
Score = 104 bits (260), Expect = 8e-22
Identities = 219/1020 (21%), Positives = 361/1020 (35%), Gaps = 151/1020 (14%)
Query: 612 RVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIA 671
+V IP G P T+TW+KD + + +I+N D +S L I ++ G Y
Sbjct: 27290 QVLIP---FKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTI 27346
Query: 672 RNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGV 731
N + + V K + P + K V S+G
Sbjct: 27347 ENGVGEPKSST-----VSVKVLDTPAACQKLQVKHV------------------SRGTVT 27383
Query: 732 PQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLC--KVSNDVGADVSKSMYLTVKIPAM 789
+ P ++G GS +I +V+E+ VS+ + K + L+ K P
Sbjct: 27384 LLWDPPLIDG-------GSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFF 27436
Query: 790 I---------------TSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMAR 834
T+ P +++S + +I+ W K D +
Sbjct: 27437 FRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITE 27496
Query: 835 YLVSTKEVGEEVISTLQILPT-------VREDSGF-FSCHAINSYG--EDRGIIQLTVQE 884
Y+V K GE+ S I T ++E S F A N G + I +TV+E
Sbjct: 27497 YVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKE 27556
Query: 885 PPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNS 944
PE+++ D+ +T+R P G S SW KD P S
Sbjct: 27557 LIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGK----PKPSISW-----LKDGLPLKES 27607
Query: 945 ATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAA--------------PDGPPQE 990
+ + I + KN K E + T+ D A P P
Sbjct: 27608 EFV--RFSKTENKITLSIKN--AKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGP 27663
Query: 991 VHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYT 1050
+ + I + S+ ++W P+ + G I Y I RE S Q N V +S +
Sbjct: 27664 IRFDEIKADSVILSWDVPEDN-GGGEITCYSIEKRETS-----QTNWKMVCSSVARTTFK 27717
Query: 1051 LDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQAIATSPESISISW 1109
+ NL K +Y V+A NR G P II + PP + + +S++W
Sbjct: 27718 VPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYNVTSDGMSLTW 27777
Query: 1110 STLSKEALNGILQGFRV-------IYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYS 1162
+ + GF V I W + + + T GL + +Y
Sbjct: 27778 DAPVYDG-GSEVTGFHVEKKERNSILWQKVNTSPISGREYRAT--------GLVEGLDYQ 27828
Query: 1163 IQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI-IRK 1221
+V A AG S+ PP + + + W PPL+ G I
Sbjct: 27829 FRVYAENSAGLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLRDGGSKIVG 27888
Query: 1222 YTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPL 1281
Y++ + Y + LS +Y ++A + G T+ P
Sbjct: 27889 YSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVG--------TISPP 27940
Query: 1282 AKAPARILT---------------FSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGT 1326
+++ I+T F G + + + + G P P V W KD
Sbjct: 27941 SQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSG-ESLRIKALVQGRPVPRVTWFKDGVEI 27999
Query: 1327 PSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQ--PR 1384
+ ++ + + S +R + G Y+ A N GS + + ++VQ P +
Sbjct: 28000 EKRMNME-ITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGP 28058
Query: 1385 LTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKC 1443
+ + T +TL W P ++G + I YI++ E + W +SY L
Sbjct: 28059 IRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLIN 28118
Query: 1444 GTWYKFTLTAQNGVGPGR--ISEIIEAK---TLGKEPQFSKEQELFA-SINTTRVRLNLI 1497
G Y+F ++A N G GR S+ + A+ T+ P + + SI T R
Sbjct: 28119 GNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPE-- 28176
Query: 1498 GWNDGGCPITSFTLEYRPFGTTVW--TTAQRTSLSKSYILYDLQEATWYELQMRVCNSAG 1555
+DGG I + LE R +T W ++R + + L E YE + N+AG
Sbjct: 28177 --SDGGSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVMAENAAG 28234
Score = 104 bits (259), Expect = 1e-21
Identities = 152/624 (24%), Positives = 244/624 (39%), Gaps = 59/624 (9%)
Query: 986 GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGD 1045
GPP E I S+ W+ P + II Y + ++ + + I V ++
Sbjct: 14803 GPPINFVFEDIRKTSVLCKWEPPLDDGGSEIIN-YTLEKKDKTKPDS---EWIVVTSTLR 14858
Query: 1046 SEVYTLDNLNKFTQYGLVVQACNRAGTGPS--SQEIITTTLEDVPSYPPENVQAIATSPE 1103
Y++ L + +Y V+A NR G GP S+ ++ P P + + TS
Sbjct: 14859 HCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTS-N 14917
Query: 1104 SISISWSTLSKEALNGIL------QGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEK 1157
S+ + W+ K+ + IL + +W+ + L +K +DGL +
Sbjct: 14918 SMLVKWNE-PKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALK--------ANVDGLLE 14968
Query: 1158 YTNYSIQVLAFTRAGDGVRSEQIFTRTKEDV---PGPPAGVKAAAASASMVFVSWLPP-L 1213
Y +V A AG G S +T D PGPP + S++ + + W PP
Sbjct: 14969 GLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIP-RVTDTSSTTIELEWEPPAF 15027
Query: 1214 KLNGIIRKYTVFCSHPYPTVISEFEASPDSF----SYRIPNLSRNRQYSVWVVAVTSAGR 1269
G I Y V +E+ + Y + + Y + V AV +AG
Sbjct: 15028 NGGGEIVGYFV---DKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGE 15084
Query: 1270 GNSSEI--ITVEPLAKAPARILTFS--GTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNG 1325
G E +TV + PA L S G + K + +P G P P W K+
Sbjct: 15085 GPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGE 15144
Query: 1326 TPS-LVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV-QVPPDQP 1383
V ID ++ + II+ +D G Y A N+ GS ++V VP
Sbjct: 15145 LDKDRVVID---NVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVPGPVL 15201
Query: 1384 RLTVSKTTSSSITLSWL-PGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLK 1442
L T L+W P D+GGS I G+I++ + W PI + L
Sbjct: 15202 DLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQ-PIETERSKCDITGLL 15260
Query: 1443 CGTWYKFTLTAQNGVG---PGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGW 1499
G YKF + A+N G P I I+ LG P S E+ + + + L+ W
Sbjct: 15261 EGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLG--PPTSPERLTYTERTKSTITLD---W 15315
Query: 1500 ----NDGGCPITSFTLEYRPFGTTVWTTA-QRTSLSKSYILYDLQEATWYELQMRVCNSA 1554
++GG PI + +E R + +R + S+++ +L E YE +++ N
Sbjct: 15316 KEPRSNGGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEI 15375
Query: 1555 GCAEKQANFATLNYDGSTIPPLIK 1578
G +E + D +PP IK
Sbjct: 15376 GESEPSLPLNVVIQD-DEVPPTIK 15398
Score = 103 bits (256), Expect = 2e-21
Identities = 144/651 (22%), Positives = 246/651 (37%), Gaps = 69/651 (10%)
Query: 986 GPPQEVHLEPISSQSIRVTWKAPKK----HLQNGIIRGYQIGYREYSTGGNFQFNIISVD 1041
GP + + + +SS V W P+ +QN I+ + +ST + +++
Sbjct: 18298 GPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNYILEKCETKRMVWST---YSATVLTPG 18354
Query: 1042 TSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGP--SSQEIITTTLEDVPSYPPENVQAIA 1099
T T+ L + +Y V+A N+ GTGP S+ +I T D P P + +
Sbjct: 18355 T-------TVTRLIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRP-DPPEVTK 18406
Query: 1100 TSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYT 1159
S E +++ W+ + I F + + + +++ L
Sbjct: 18407 VSKEEMTVVWNPPEYDGGKSITGYF--LEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDH 18464
Query: 1160 NYSIQVLAFTRAGDG---VRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLN 1216
Y +V A G G + S + + + PGPP + + + + W P+
Sbjct: 18465 EYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDG 18524
Query: 1217 GI-IRKYTVFCSHPYPTVISEFEASPDSF-------------SYRIPNLSRNRQYSVWVV 1262
G I Y V P + +ASPD + + +L N++Y V
Sbjct: 18525 GAPIIGYVV---EMRPKIA---DASPDEGWKRCNAAAQLVRKEFTVTSLDENQEYEFRVC 18578
Query: 1263 AVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVL-----PCKAV----GDP 1313
A G G +E+ A P IL M+ +V+ P + G P
Sbjct: 18579 AQNQVGIGRPAELKE----AIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRP 18634
Query: 1314 SPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILN 1373
+P V W K G ++V + + +I +DSG YS N G + +N
Sbjct: 18635 APKVTWRKV--GIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVN 18692
Query: 1374 LQV-QVPPDQPRLTVSKTTSSSITLSWLPGDN-GGSSIRGYILQYSEDNSEQWGSFPISP 1431
++V P L VS T +S +SW P +N GGS + YI++ E + + W +
Sbjct: 18693 VRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTPEV 18752
Query: 1432 SERSYRLENLKCGTWYKFTLTAQNGVGPGRISEI---IEAKTLGKEPQFSKEQELFASIN 1488
+ S+ + NL G Y F +TA N GPG +++ + A EP ++ E+
Sbjct: 18753 KKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTK 18812
Query: 1489 TTRVRLNLIGWNDGGCPITSFTLEYRPFGTTV--WTTAQRTSLSKSYILYDLQEATWYEL 1546
+ L DGG I + YR WT S ++ L+E Y+
Sbjct: 18813 NSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVK-DLSLVVTGLKEGKKYKF 18871
Query: 1547 QMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKMLV 1597
++ N+ G + + +PP I E +T G K+ +
Sbjct: 18872 RVAARNAVGVSLPREAEGVYEAKEQLLPPKILM----PEQITIKAGKKLRI 18918
Score = 103 bits (256), Expect = 2e-21
Identities = 188/824 (22%), Positives = 315/824 (38%), Gaps = 108/824 (13%)
Query: 818 IVRWEKEDRIINPEMARYLVSTKEVGE----EVISTLQILPTVR---EDSGF-FSCHAIN 869
++ W K D + YL+ ++ G E T Q+ TV E + + F A N
Sbjct: 28563 VLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKN 28622
Query: 870 S--YGEDR-GIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDI------ 920
Y E R + ++EP P ++ + + IT + F + PI+G
Sbjct: 28623 DAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWK 28682
Query: 921 --ECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTIT 978
E + K S TKD + + T+ D + + +N G S + +
Sbjct: 28683 LEEMRLKETDRVSITTTKDRT----TLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVI 28738
Query: 979 ADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNII 1038
GP + + +S++S ++W PK I Y + RE T +Q
Sbjct: 28739 GRPGPVTGP---IEVSSVSAESCVLSWGEPKDG-GGTEITNYIVEKRESGTTA-WQL--- 28790
Query: 1039 SVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQA 1097
V++S + +L K+ +Y V + NR G P I VP P +
Sbjct: 28791 -VNSSVKRTQIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEV 28849
Query: 1098 IATSPESISISWSTLSKEALNGILQGFRVI-YWANLMDGEL---GEIKNITTTQPSLELD 1153
S ++SI W + G ++I YW + + + + + ++
Sbjct: 28850 YHVSANAMSIRWEEPYHDG------GSKIIGYWVEKKERNTILWVKENKVPCLECNYKVT 28903
Query: 1154 GLEKYTNYSIQVLAFTRAGDGVRSEQ---IFTRTKEDVPGPPAGVKAAAASASMVFVSWL 1210
GL + Y + A AG SE I + D PG P ++ S++ W
Sbjct: 28904 GLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLI---WS 28960
Query: 1211 PPLKLNG------IIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAV 1264
P G II + V + + D+F + + LS Y V+A
Sbjct: 28961 APAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNF-FTVTALSEGDTYEFRVLAK 29019
Query: 1265 TSAG----RGNSSEIITVE-----PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSP 1315
+AG S+ +T P A+ AR+ VT D+VL G P P
Sbjct: 29020 NAAGVISKGSESTGPVTCRDEYAPPKAELDARL--HGDLVTIRAGSDLVLDAAVGGKPEP 29077
Query: 1316 AVKWMKDSNGTPSLVTID----GRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEII 1371
+ W K + G+R+ + +I+ DSG Y+ N G+ +
Sbjct: 29078 KIIWTKGDKELDLCEKVSLQYTGKRA-----TAVIKFCDRSDSGKYTLTVKNASGTKAVS 29132
Query: 1372 LNLQV-QVPPDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPI 1429
+ ++V P +LTVS+ T TL+W LP ++GG+ I YI++ E + W
Sbjct: 29133 VMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEG 29192
Query: 1430 SPSERSYRLENLKCGTWYKFTLTAQNGVGPG--RISEIIEAK---TLGKEPQFSKEQELF 1484
SY + L Y F + A N GPG SE I A+ T+ P +E
Sbjct: 29193 ECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEE---- 29248
Query: 1485 ASINTTRVRLNLIGW----NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYD--- 1537
+ T + + +I W +DGG I+++ ++ R + W T ++K Y++YD
Sbjct: 29249 --VGTGKEHI-IIQWTKPESDGGNEISNYLVDKREKKSLRW-----TRVNKDYVVYDTRL 29300
Query: 1538 ----LQEATWYELQMRVCNSAGCAE--KQANFATLNYDGSTIPP 1575
L E Y+ ++ N+AG +E + +NF + T P
Sbjct: 29301 KVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGP 29344
Score = 102 bits (254), Expect = 4e-21
Identities = 170/706 (24%), Positives = 263/706 (37%), Gaps = 58/706 (8%)
Query: 884 EPPDPP-EIEIKDVKARTITLRWTMGF-DGNSPITGYDIECKNKSDS-WDSAQRTKDVSP 940
+PP PP ++KD T L WT DG SPI GY +EC+ + W+ KD
Sbjct: 17802 KPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRIN--KDELI 17859
Query: 941 QLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN--ELTITADEAAPDGPPQEVHLEPISS 998
+ + + + + Y R+ A N +G+ EP E I D P EV L+
Sbjct: 17860 RQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPP----EVELDVTCR 17915
Query: 999 QSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKF- 1057
I V + L ++G ++ G VD D L
Sbjct: 17916 DVITVRVGQTIRILAR--VKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVR 17973
Query: 1058 TQYG-LVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEA 1116
+G ++ A N +G S + + D P P +N++ + E+ +ISW
Sbjct: 17974 ADHGKYIISAKNSSGHAQGSAIV---NVLDRPG-PCQNLKVTNVTKENCTISWENPLDNG 18029
Query: 1117 LNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVR 1176
+ I F V Y G ++T L L Y +V A + G G
Sbjct: 18030 GSEITN-FIVEYRKPNQKGWSIVASDVTKR---LIKANLLANNEYYFRVCAENKVGVGPT 18085
Query: 1177 SEQ---IFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIR-----KYTVFCSH 1228
E I D PG P + A + V++ W P G + + S
Sbjct: 18086 IETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSD 18145
Query: 1229 PYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGN---SSEIITVEPLAKAP 1285
+ V + S Y + N+ Y V G + + E++ E L K P
Sbjct: 18146 DWERV---HKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQK-P 18201
Query: 1286 ARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGT----PSLVTIDGRRSIFSN 1341
L SG +T I L G P P V W KD + T V ID R +
Sbjct: 18202 VLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRA---DS 18258
Query: 1342 GSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSW- 1399
F + K D G Y A N GS + V P R L + +S T+ W
Sbjct: 18259 SKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWD 18318
Query: 1400 LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQN--GV 1457
P D+GG I+ YIL+ E W ++ + + L G Y F + A+N G
Sbjct: 18319 PPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGT 18378
Query: 1458 GPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN----DGGCPITSFTLEY 1513
GP S+ + AKT +P E+ ++ + ++ WN DGG IT + LE
Sbjct: 18379 GPPTESKPVIAKTKYDKPGRPDPPEV---TKVSKEEMTVV-WNPPEYDGGKSITGYFLEK 18434
Query: 1514 RPFGTTVWTTAQRTSLSKSYI-LYDLQEATWYELQMRVCNSAGCAE 1558
+ +T W ++++ + + + +L Y+ +++ N G E
Sbjct: 18435 KEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGE 18480
Score = 101 bits (251), Expect = 8e-21
Identities = 177/794 (22%), Positives = 293/794 (36%), Gaps = 117/794 (14%)
Query: 750 SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV---------KIPAMITSYPNTTLAT 800
S L++++ E + K N++G + S+ L V I ++ +T
Sbjct: 15353 SFLVENLDEHQMYEFRVKAVNEIG-ESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVK 15411
Query: 801 QGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVIST-LQILPTVRED 859
G+ + G + W K + +I ++ +EV T L I VRED
Sbjct: 15412 AGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVRED 15471
Query: 860 SGFFSCHAINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKARTITLRWTMGFD-GNSPITG 917
G ++ A N G + + V + P PP + + D+KA + L W D G S IT
Sbjct: 15472 KGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVTDIKAESCYLTWDAPLDNGGSEITH 15531
Query: 918 YDIECKNKSDSWDSAQRTKDVSPQLNSAT-----IIDIHPSSTYSIRMYAKNRIGKS-EP 971
Y I D D++++ + N+A I + P+ Y R+ A N+ G S E
Sbjct: 15532 YVI------DKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDEC 15585
Query: 972 SNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNG--IIRGYQIGYREYST 1029
++ + D GPP + + + S+ V+W P L NG I GY + RE +
Sbjct: 15586 KSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPP---LDNGGSPITGYWLEKREEGS 15642
Query: 1030 GGNFQFNIISVDTSGDSEV-YTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLED-- 1086
+ + + G V + + L + +Y A N AG GP S+ D
Sbjct: 15643 PYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPEVAGDPI 15702
Query: 1087 VPSYPPENVQAIATSPESISISWSTLSKEALNGI------LQGFRVIYWANLMDGELGEI 1140
P PP + + SIS+ W +K+ + I +Q W + + +
Sbjct: 15703 FPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIKGYIVEMQEEGTTDWKRVNEPD---- 15758
Query: 1141 KNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAA 1200
K ITT + + L++ Y +V A AG+ S+ D+ P A
Sbjct: 15759 KLITTCE--CVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGA 15816
Query: 1201 SASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEF---------------------EA 1239
+V K IR V P P EF E
Sbjct: 15817 QDCLV-------CKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMKDGVHDIPEDAQLET 15869
Query: 1240 SPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPW 1299
+ +S IP R+ + A AG+ ++ + V + P
Sbjct: 15870 AENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPP-------------- 15915
Query: 1300 MKDIVLPCKAVGDPSPAVKW-MKDSNGTPSLV-------TIDGRRSIFSN-----GSFII 1346
KD L + S + W M D +G + TIDG+ N +F++
Sbjct: 15916 -KD--LKVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRTIDGKAWTKVNPDCGSTTFVV 15972
Query: 1347 RTVKAEDSGYYSCIANNNWGSDEIILNLQVQV------PPDQP-RLTVSKTTSSSITLSW 1399
+ +E ++ A N +G + +Q PPD P +L + T +++ LSW
Sbjct: 15973 PDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGLITKNTVHLSW 16032
Query: 1400 LPGDN-GGSSIRGYILQY-----SEDNSEQWGSF-PISPSERSYRLENLKCGTWYKFTLT 1452
P N GGS + YI++ + E W E + +E+L G Y+F +
Sbjct: 16033 KPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGEYEFRVK 16092
Query: 1453 AQNGVGPGRISEII 1466
A N G + S +
Sbjct: 16093 AVNAAGVSKPSATV 16106
Score = 100 bits (248), Expect = 2e-20
Identities = 82/305 (26%), Positives = 142/305 (46%), Gaps = 28/305 (9%)
Query: 690 PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG 749
P F + R+ + Y L C G+P P + W + +G + L RIQ G
Sbjct: 30928 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKW-YRQGK---EIIADGLKYRIQEFKGG 30983
Query: 750 --SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNT------TLATQ 801
L+I V ++D+ Y + +N G VS + L V++PA I P T A +
Sbjct: 30984 YHQLIIASVTDDDATVYQVRATNQ-GGSVSGTASLEVEVPAKI-HLPKTLEGMGAVHALR 31041
Query: 802 GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSG 861
G+ + G+ ++ W+K +I+ ++ T+ V R+D+G
Sbjct: 31042 GEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPN----GVERKDAG 31097
Query: 862 FFSCHAINSYGEDRGIIQLTVQEPPDPPE-IEIKDVKARTITLRWT-MGFDGNSPITGYD 919
F+ A N +G D+ ++L V + PDPP +++ DV ++ L WT DG S IT Y
Sbjct: 31098 FYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSKITNYI 31157
Query: 920 IE-CKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS--NELT 976
+E C ++ W + ++ T+I++ ++Y R+ A+N+ G S+PS +E T
Sbjct: 31158 VEKCATTAERWLRVGQARE-----TRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPT 31212
Query: 977 ITADE 981
IT ++
Sbjct: 31213 ITKED 31217
Score = 98.6 bits (244), Expect = 5e-20
Identities = 163/729 (22%), Positives = 278/729 (38%), Gaps = 103/729 (14%)
Query: 882 VQEPPDPPEIEIKDVKARTITLRWTMG-FDGNSPITGYDIECKNKSDS-WDSAQRTKDVS 939
+ +P P E D ++ L W DG S I GY +E + D W A T +
Sbjct: 17110 IAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVGDEEWRRANHTPESC 17169
Query: 940 PQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQ 999
P+ + + TY R+ A N G+S+P++ P+ + LEP +
Sbjct: 17170 PE-TKYKVTGLRDGQTYKFRVLAVNAAGESDPAH---------VPEPVLVKDRLEP--PE 17217
Query: 1000 SIRVTWKAPKKHLQNG-------IIRGY---QIGYREYSTGGNFQFNIISVDTSGDSEVY 1049
I A ++H++ G II+G ++ +++ + I E+
Sbjct: 17218 LILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIR 17277
Query: 1050 TLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISW 1109
+ + Y L V+ N AG+ S +++ D P PP +++ +S ++W
Sbjct: 17278 NAAHEDGGI-YSLTVE--NPAGSKTVSVKVLVL---DKPG-PPRDLEVSEIRKDSCYLTW 17330
Query: 1110 STLSKEALNGILQGFRVI--YWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLA 1167
KE L+ G VI Y D + ++ T S + K+ N Q L
Sbjct: 17331 ----KEPLD---DGGSVITNYVVERRDVASAQWSPLSAT--SKKKSHFAKHLNEGNQYL- 17380
Query: 1168 FTRAGDGVRSEQIFTRTKEDV--------PGPPAGVKAAAASASMVFVSWLPPLKLNGII 1219
F A + F T + + PGPP + + V + W P + G
Sbjct: 17381 FRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGG-- 17438
Query: 1220 RKYTVFCSHPYPTVISEF--EASPDSFSYR--------IPNLSRNRQYSVWVVAVTSAGR 1269
P + E+ E + D ++ + L + + Y V A G
Sbjct: 17439 --------SPITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGL 17490
Query: 1270 GNSSEIITVEPLAK-----APARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSN 1324
G I +E K + G V + P G P P KW D
Sbjct: 17491 GLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTT-VRFPAIIRGVPVPTAKWTTDG- 17548
Query: 1325 GTPSLVTIDGRRSIFSNGSFIIRTVK---AEDSGYYSCIANNNWGSDEIILNLQVQVPPD 1381
S + D ++ ++ + T+K D+G Y +N GS + ++L V P
Sbjct: 17549 ---SEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPG 17605
Query: 1382 QPR--LTVSKTTSSSITLSWLPG-DNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRL 1438
P + + T +T+SW P D+GGS + YI++ + + WG S+ ++
Sbjct: 17606 PPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKI 17665
Query: 1439 ENLKCGTWYKFTLTAQN--GVGPGRISEIIEAK------TLGKEPQFSKEQELFASINTT 1490
+L+ G Y F + A+N GVGP S AK + +P + E A+++ T
Sbjct: 17666 PHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWT 17725
Query: 1491 RVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSK-SYILYDLQEATWYELQMR 1549
+ +DGG PIT + +E R T W +T ++ + + L E YE ++
Sbjct: 17726 LPK------SDGGSPITGYYMERREV-TGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVF 17778
Query: 1550 VCNSAGCAE 1558
N AG ++
Sbjct: 17779 AENLAGLSK 17787
Score = 98.2 bits (243), Expect = 7e-20
Identities = 243/1173 (20%), Positives = 434/1173 (36%), Gaps = 163/1173 (13%)
Query: 382 AYQCFVRKDKLSAQDYVQV--VLEDGTPKIISAFSEKVVSPA-EPVSLMCNVKGTPLPTI 438
A C + + + + VQ +LE + A V++ A E V ++ KG P PT+
Sbjct: 27244 AVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTV 27303
Query: 439 TWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQAR 498
TW D+ + + I +S S L I D G Y T N G
Sbjct: 27304 TWRKDEKNLGSDARYSIENTDSS-----SLLTIPQVTRNDTGKYILTIENGVG------- 27351
Query: 499 INVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGT 558
P + ++ DT C+ + + S + + L ++ + + G+
Sbjct: 27352 ---------EPKSSTVSVKVLDTPAACQKLQVKHVS----RGTVTLLWDPPLI---DGGS 27395
Query: 559 LKLSDVQKEVDEGEYTCNVLVQPQLSTS-QSVHVTVKVPPFIQPFEFPRFSIGQRVFIPC 617
++ V ++ D + T +V+ STS + + ++ K P F + IG+
Sbjct: 27396 PIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTE 27455
Query: 618 VVVSGDLP---------------ITITWQK---DG----------RPIPGSLGVTIDNID 649
V + ++P + ++W K DG R G + I
Sbjct: 27456 PVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGIS 27515
Query: 650 FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVI- 708
T + +S L + A+NE + + + V + D I G V
Sbjct: 27516 KTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTV 27575
Query: 709 -------LNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDS 761
L +G P P+I W G + + + + + + + +L IK+ +E
Sbjct: 27576 RIGHNVHLELPYKGKPKPSISW-LKDGLPLKESEFVRFS---KTENKITLSIKNAKKEHG 27631
Query: 762 GYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRW 821
G Y + N V +T+ P S P + K + +I+ W
Sbjct: 27632 GKYTVILDNAVCRIAVPITVITLGPP----SKPKGPIRFDEIKAD---------SVILSW 27678
Query: 822 EKEDRIINPEMARYLVSTKEVGE--------EVISTLQILPTVREDSGF-FSCHAINSYG 872
+ + E+ Y + +E + V T +P + +D+ + F A N YG
Sbjct: 27679 DVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDAEYQFRVRAENRYG 27738
Query: 873 EDRGII--------QLTVQEPPDPPEIEIKDVKARTITLRWTMG-FDGNSPITGYDIECK 923
+ ++ Q + PP P I +V + ++L W +DG S +TG+ +E K
Sbjct: 27739 VSQPLVSSIIVAKHQFRIPGPPGKP--VIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKK 27796
Query: 924 NKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS--NELTITADE 981
++ T +S + AT + Y R+YA+N G S PS ++ T+
Sbjct: 27797 ERNSILWQKVNTSPISGREYRAT--GLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSP 27854
Query: 982 AAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVD 1041
P G P + ++ ++I + W P + + I+ GY I R+ GN ++ +
Sbjct: 27855 VDPPGTPDYI---DVTRETITLKWNPPLRDGGSKIV-GYSIEKRQ----GNERWVRCNFT 27906
Query: 1042 TSGDSEVYTLDNLNKFTQYGLVVQACNRAGT-GPSSQE--IITTTLEDVP---SYPPENV 1095
+ + YT+ L+ +Y + A N GT P SQ II T E+VP + PE
Sbjct: 27907 DVSECQ-YTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYF 27965
Query: 1096 QA-IATSPESISISWSTLSKEALNGILQGF---RVIYWANLMDGELGEIKNITTTQPSLE 1151
I S ES+ I ++QG RV ++ + ++ E IT S
Sbjct: 27966 DGLIIKSGESLRI----------KALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTS 28015
Query: 1152 LDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAG-VKAAAASASMVFVSWL 1210
L + ++ + G +I + +D PG G ++ + + + W
Sbjct: 28016 LFVRDATRDHRGVYTVEAKNASGSAKAEIKVKV-QDTPGKVVGPIRFTNITGEKMTLWWD 28074
Query: 1211 PPLKLN-GIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGR 1269
PL I Y + + E ++ SY L +Y V AV G
Sbjct: 28075 APLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGV 28134
Query: 1270 G---NSSEII-----TVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMK 1321
G +S ++ TV P ++T W + P G +
Sbjct: 28135 GRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWAR----PESDGGSEIQQYILER 28190
Query: 1322 DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN------NWGSDEIILNLQ 1375
+ V + +R I S F + + + + +A N G +I +
Sbjct: 28191 REKKSTRWVKVISKRPI-SETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCRE 28249
Query: 1376 VQVPPDQPRLT-VSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSE 1433
PP P + V+ T+ ++++L W P +GG I GYI++ + + W
Sbjct: 28250 PVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGDWHKVNAEACV 28309
Query: 1434 RS-YRLENLKCGTWYKFTLTAQNGVGPGRISEI 1465
++ Y + +L+ G YKF ++A NG G G E+
Sbjct: 28310 KTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEV 28342
Score = 92.0 bits (227), Expect = 5e-18
Identities = 222/1077 (20%), Positives = 387/1077 (35%), Gaps = 153/1077 (14%)
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTVKV-------PPFIQPFEFPRFSI----GQRVFIPC 617
+ EY V + Q S + + V PP I FP ++ G + +
Sbjct: 26439 ENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDI 26498
Query: 618 VVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAA 677
+ LP +T +DG P+ ++ + ++ + G Y A N +
Sbjct: 26499 PISGKPLP-KVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEITAANSSGT 26557
Query: 678 VEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPI 737
+ ++V P P VI + + E + K+ G+ V + +
Sbjct: 26558 TKAFINIVVLDRPGPPTGP---------VVISDITEESVTLKWEPPKYDGGSQVTNYILL 26608
Query: 738 ALNGRIQVLSNGSLLIKHVVEE-------DSGYYLCKVSNDVG-ADVSKSMYLTVKIPAM 789
V + S + + + + + K N G +D S +TVK+P
Sbjct: 26609 KRETSTAVWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYT 26668
Query: 790 ITSYPNTTLATQGQKKEMSCTAH------GEKPIIVRWEKEDR--IINPEMARYLVSTKE 841
P+T T ++ ++ H G + E +DR I+ + + ++ T
Sbjct: 26669 TPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTH 26728
Query: 842 VGEEVISTLQILPTVREDSGFFSCHAINSYGEDRG------IIQLTVQEPPDPPEIEIKD 895
IS I F +A N+ G + ++ + EPP + I D
Sbjct: 26729 FKVTTISAGLIYE--------FRVYAENAAGVGKPSHPSEPVLAIDACEPPR--NVRITD 26778
Query: 896 VKARTITLRWTM-GFDGNSPITGYDIECKNKSDS-WDSAQRTKDVSPQLNSATIIDIHPS 953
+ +++L W FDG S ITGY +E ++ D W A T Q I + +
Sbjct: 26779 ISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQF---IISGLTQN 26835
Query: 954 STYSIRMYAKNRIGK-SEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHL 1012
S Y R++A+N +G S PS + + GP ++ LE R L
Sbjct: 26836 SQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRA---GTSVKL 26892
Query: 1013 QNGIIRGYQIGYREYSTGGNFQFN-IISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAG 1071
+ GI Y Q N ++ V+ + D + + ++ ++ N G
Sbjct: 26893 RAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMG 26952
Query: 1072 TGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGIL-------QGF 1124
S+ I + D P P ++ + E I++ W + + I +
Sbjct: 26953 ---SASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETS 27009
Query: 1125 RVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDG--VRSEQIFT 1182
RV+ W+ M E E ITTT+ + K Y +V A + G G + S+ +
Sbjct: 27010 RVV-WS--MVSEHLEECIITTTK-------IIKGNEYIFRVRAVNKYGIGEPLESDSVVA 27059
Query: 1183 RTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPYPTVISEFEASP 1241
+ PGPP + + + + V W P+ G I Y F + F+
Sbjct: 27060 KNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGY--FLEKRDKKSLGWFKVLK 27117
Query: 1242 DSFS---YRIPNLSRNRQYSVWVVAVTSAGRGNSSE----IITVEPLAKA--PARILTFS 1292
++ ++ L+ N Y V AV +AG+G SE +P+ PA+I
Sbjct: 27118 ETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIAD 27177
Query: 1293 GT---VTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTV 1349
T +T W K + AV ++ ++ T T+ + + + +++ +
Sbjct: 27178 STKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWT----TVSTKGEVRTT-EYVVSNL 27232
Query: 1350 KAEDSGYYSCIANNNWGSDEII-LNLQVQVPP--DQPRLTVSKTTSSSI----------- 1395
K + Y+ A N G E I +N VQ + P + + +S+
Sbjct: 27233 KPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVL 27292
Query: 1396 ---------TLSWLPGD-NGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGT 1445
T++W + N GS R YS +N++ I R+
Sbjct: 27293 IPFKGRPPPTVTWRKDEKNLGSDAR-----YSIENTDSSSLLTIPQVTRN---------D 27338
Query: 1446 WYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN----D 1501
K+ LT +NGVG + S + K L K Q S T + W+ D
Sbjct: 27339 TGKYILTIENGVGEPK-SSTVSVKVLDTPAACQKLQVKHVSRGTVTLL-----WDPPLID 27392
Query: 1502 GGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAE 1558
GG PI ++ +E R W+ S S+ L DL E T + ++ N G E
Sbjct: 27393 GGSPIINYVIEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGE 27449
Score = 91.7 bits (226), Expect = 7e-18
Identities = 147/669 (21%), Positives = 251/669 (37%), Gaps = 75/669 (11%)
Query: 936 KDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAA------------ 983
KD P L T +++ ++T ++ ++ K G + + T+TA +A
Sbjct: 24347 KDGEP-LKQTTRVNVEETATSTV-LHIKE--GNKDDFGKYTVTATNSAGTATENLSVIVL 24402
Query: 984 --PDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVD 1041
P P V + +S+ + ++W+ P + I Y + R+ +T ++++S
Sbjct: 24403 EKPGPPVGPVRFDEVSADFVVISWEPPA-YTGGCQISNYIVEKRDTTTT---TWHMVSAT 24458
Query: 1042 TSGDSEVYTLDNLNKFTQYGLVVQACNRAG-TGPSSQEIITTTLEDVPSYPPENVQAIAT 1100
+ + T L T+Y + A NR G + P + + PP +
Sbjct: 24459 VARTTIKIT--KLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSI 24516
Query: 1101 SPESISISWSTLSKEALNGILQGFRV-------IYWANLMDGELGEIKNITTTQPSLELD 1153
S + + + W + I+ G+ + I W L + + K TT
Sbjct: 24517 SKDQMLVQWHEPVNDGGTKII-GYHLEQKEKNSILWVKLNKTPIQDTKFKTT-------- 24567
Query: 1154 GLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPL 1213
GL++ Y +V A G G S+ D PP +A + + V + W P
Sbjct: 24568 GLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPA 24627
Query: 1214 KLNGIIRKYTVFCSHPYPTVISEFEASPD------SFS------YRIPNLSRNRQYSVWV 1261
G K T + I E + PD SF+ + + L +++Y V
Sbjct: 24628 YDGG--SKITGY--------IVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRV 24677
Query: 1262 VAVTSAGR----GNSSEIITVEPLAKAPARIL--TFSGTVTTPWMKDIVLPCKAVGDPSP 1315
+A +AG +SS IT AP L + + + VL G P P
Sbjct: 24678 IARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIP 24737
Query: 1316 AVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQ 1375
V W KD +S + +++ D G Y +N G+ I + ++
Sbjct: 24738 DVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVK 24797
Query: 1376 VQVPPDQPR--LTVSKTTSSSITLSWLPG-DNGGSSIRGYILQYSEDNSEQWGSFPISPS 1432
V P P L V+ T+ L+W P +GG++I YI++ E + W
Sbjct: 24798 VLDRPGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQ 24857
Query: 1433 ERSYRLENLKCGTWYKFTLTAQN--GVGPGRISEIIEAKTLGKEPQFSKEQELFASINTT 1490
+Y++ L G Y F + A N G+G S + A K P E+ A +
Sbjct: 24858 ALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDS 24917
Query: 1491 RVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYI-LYDLQEATWYELQMR 1549
V +DGG I + LE R WT + +L+ + + L E YE ++
Sbjct: 24918 MVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVA 24977
Query: 1550 VCNSAGCAE 1558
N+AG E
Sbjct: 24978 AENAAGVGE 24986
Score = 90.9 bits (224), Expect = 1e-17
Identities = 125/558 (22%), Positives = 210/558 (37%), Gaps = 79/558 (14%)
Query: 689 PPKFVVQP---RDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQV 745
PP+ ++ R+Q G + L+ +G P P + WK + + RI V
Sbjct: 17215 PPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWK-------KEDRDAPTKARIDV 17267
Query: 746 LSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQK 804
GS L I++ ED G Y V N G+ TV + ++ P G
Sbjct: 17268 TPVGSKLEIRNAAHEDGGIYSLTVENPAGSK-------TVSVKVLVLDKP-------GPP 17313
Query: 805 KEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-- 862
+++ + + + W++ + Y+V ++V S L T ++ S F
Sbjct: 17314 RDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLS--ATSKKKSHFAK 17371
Query: 863 ---------FSCHAINSYGE------DRGIIQLTVQEPPDPP-EIEIKDVKARTITLRWT 906
F A N YG + I L PP PP ++ DV ++L W
Sbjct: 17372 HLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWN 17431
Query: 907 M-GFDGNSPITGYDIECKNK-SDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKN 964
DG SPITGY +E + + + W + ++ + + TY R+ A+N
Sbjct: 17432 KPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNL-----ECVVTGLQQGKTYRFRVKAEN 17486
Query: 965 RIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGY 1024
+G P + I E P V L+ + + V KA IIRG +
Sbjct: 17487 IVGLGLPDTTIPIECQEKL---VPPSVELDVKLIEGLVV--KAGTTVRFPAIIRGVPVPT 17541
Query: 1025 REYSTGGN--FQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITT 1082
+++T G+ +V+T S V T+ N + + N AG S +
Sbjct: 17542 AKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAG---SKTVAVHL 17598
Query: 1083 TLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGIL------QGFRVIYWANLMDGE 1136
T+ DVP P + + +PE ++ISW + + ++ Q R W + G
Sbjct: 17599 TVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSG- 17657
Query: 1137 LGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDG--VRSEQIFTRTKEDVPGPPAG 1194
+++ L++ L+K Y +V A + G G + S + K P PP
Sbjct: 17658 --------SSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGK 17709
Query: 1195 VKAAAASASMVFVSWLPP 1212
+ + VSW P
Sbjct: 17710 PVVTDITENAATVSWTLP 17727
Score = 90.9 bits (224), Expect = 1e-17
Identities = 197/891 (22%), Positives = 337/891 (37%), Gaps = 113/891 (12%)
Query: 656 ISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGI------YGKAVIL 709
I+NL+ + +A NE + +S + V V++P + G+ + +
Sbjct: 23190 ITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKI 23249
Query: 710 NCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVS 769
G P PTI W G+P Q +N L +L IK ++D G Y V+
Sbjct: 23250 EVPISGRPKPTITWTKD---GLPLKQTTRINVT-DSLDLTTLSIKETHKDDGGQYGITVA 23305
Query: 770 NDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIIN 829
N VG + +T+ P +G K +A + I + W
Sbjct: 23306 NVVGQKTASIEIVTLDKPD----------PPKGPVKFDDVSA---ESITLSWNPPLYTGG 23352
Query: 830 PEMARYLVSTKEVGE---EVIS------TLQILPTVREDSGFFSCHAINSYGE------D 874
++ Y+V ++ +V+S TL++ F A N YG+ D
Sbjct: 23353 CQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESD 23412
Query: 875 RGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGF-DGNSPITGYDIECKNK-SDSWDSA 932
+ Q +EP P + ++ ++W +G SP+ GY +E K + S W
Sbjct: 23413 PIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKV 23472
Query: 933 QRTKDVSPQLNSATIIDIHPSSTYSIRMYAKN--RIGKSEPSNELTITADEAAPDGPPQE 990
+T Q + ++ Y R+YA+N +GK+ ++E + D P G P+
Sbjct: 23473 NKTIIHDTQFKAQ---NLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTPEP 23529
Query: 991 VHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYT 1050
+ + I + W P + +I GY + R+ G + + +V + +T
Sbjct: 23530 I---MVKRNEITLQWTKP-VYDGGSMITGYIVEKRDLPDGRWMKASFTNVIET----QFT 23581
Query: 1051 LDNLNKFTQYGLVVQACNRAG--TGPSSQEIITTTLEDVP----SYPPENVQAIATSPES 1104
+ L + +Y V A N AG + PS T ++V S P+ I +
Sbjct: 23582 VSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGE 23641
Query: 1105 ISISWSTLSKEALNGI--LQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYS 1162
+ + + L I L+G + I + + + + K + + ++ +DG +
Sbjct: 23642 TFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQ------ 23695
Query: 1163 IQVLAFTRAGDGVRSEQIFTRTKE-DVPGPPAG-VKAAAASASMVFVSWLPPLKLNGI-I 1219
RA + S+ K D PGPP G V+ ++ ++W PPL+ G I
Sbjct: 23696 ----YILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDI 23751
Query: 1220 RKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVE 1279
Y V + + + S ++ L +Y ++AV G G E
Sbjct: 23752 SHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVG--------E 23803
Query: 1280 PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMK-DSNGTPSLVTI------ 1332
PL AP +L + V K L + S V W + DS+G ++
Sbjct: 23804 PLESAP--VLMKNPFVLPGPPKS--LEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRD 23859
Query: 1333 -DGRRSIFSNGSFIIR-----TVKAEDSGY-YSCIANNNWGSDE---IILNLQVQVPPDQ 1382
G R I N I T ED Y + A N G E + + P +
Sbjct: 23860 RSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFK 23919
Query: 1383 P----RLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYR 1437
P + TT +SITL+W P +GGS I GY+++ + + E+W R R
Sbjct: 23920 PGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTR 23979
Query: 1438 LENLKCGTW--YKFTLTAQNGVGPGRISEI---IEAKTLGKEPQFSKEQEL 1483
E K YK + A N VG G + + ++ + + P+ + EL
Sbjct: 23980 FEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLDSEL 24030
Score = 90.9 bits (224), Expect = 1e-17
Identities = 158/719 (21%), Positives = 269/719 (37%), Gaps = 73/719 (10%)
Query: 618 VVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAA 677
+V DLP DGR + S ++ +FT +S L + IARN A
Sbjct: 24638 IVEKKDLP-------DGRWMKASFTNVLET-EFT----VSGLVEDQRYEFRVIARNAAGN 24685
Query: 678 VEHQSQLIVRVP-------PKFVVQPRDQDGIY---GKAVILNCSAEGYPVPTIVWKFSK 727
S + P + P+ +D I G+ +L G P+P +VW SK
Sbjct: 24686 FSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVW--SK 24743
Query: 728 GAGVPQFQPIALNGRIQ-VLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKI 786
+ + A I+ + +L++K + D G Y+ K+SN G +KS+ +TVK+
Sbjct: 24744 DG--KELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNVGG---TKSIPITVKV 24798
Query: 787 PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEV 846
P L G E C P+ I + +S +V EV
Sbjct: 24799 LDR-PGPPEGPLKVTGVTAE-KCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQVSTEV 24856
Query: 847 IS-TLQILPTVREDSGFFSCHAINSYG-----EDRGIIQLTVQEPPDPPEI-EIKDVKAR 899
+ ++ + + F A+N YG E + +PP PP E+ +
Sbjct: 24857 QALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKD 24916
Query: 900 TITLRWTMGFD-GNSPITGYDIECKNKSD-SWDSAQRTKDVSPQLNSATIIDIHPSSTYS 957
++ + W D G + I GY +E ++K W + +L + + H +Y
Sbjct: 24917 SMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEGH---SYE 24973
Query: 958 IRMYAKNRIGKSEPSNELTI--TADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNG 1015
R+ A+N G EPS D P GPP + S S+ + W P +
Sbjct: 24974 FRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKP-IYDGGA 25032
Query: 1016 IIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-P 1074
++GY + +E + ++ + T + +T+ L + T+Y + A N G G P
Sbjct: 25033 PVKGYVVEVKEAAAD---EWTTCTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEP 25089
Query: 1075 SSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMD 1134
++ E + PPE ++ A + + + S + + + + W +
Sbjct: 25090 ATLPGSVVAQERIE--PPE-IELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEK-AE 25145
Query: 1135 GELGEIKNI--TTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKE-DVPGP 1191
G L + I T++ L +D + ++ + + +G S+ F + D P
Sbjct: 25146 GILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSG----SKTAFVNVRVLDSPSA 25201
Query: 1192 PAGVKAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPYPTVISEFEASPDSFSYRIPN 1250
P + V +SW PPL G I Y V + + ++RI N
Sbjct: 25202 PVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIEN 25261
Query: 1251 LSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKA-----PARILTFS---GTVTTPWMK 1301
L Y V+A G G +E T EP+ + P R+ T T W K
Sbjct: 25262 LQEGCSYYFRVLASNEYGIGLPAE--TTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEK 25318
Score = 88.6 bits (218), Expect = 6e-17
Identities = 138/645 (21%), Positives = 240/645 (37%), Gaps = 47/645 (7%)
Query: 939 SPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISS 998
S L + +I + H + N +G+ S E+ +T D+ PD P V + +S+
Sbjct: 23281 SLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEI-VTLDK--PDPPKGPVKFDDVSA 23337
Query: 999 QSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFT 1058
+SI ++W P + I Y + R+ +T ++++S + + T L T
Sbjct: 23338 ESITLSWNPPL-YTGGCQITNYIVQKRDTTTT---VWDVVSATVARTTLKVT--KLKTGT 23391
Query: 1059 QYGLVVQACNRAGTGPS--SQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEA 1116
+Y + A NR G + S I+ P PP A A S +S+ I W
Sbjct: 23392 EYQFRIFAENRYGQSFALESDPIVAQYPYKEPG-PPGTPFATAISKDSMVIQWHEPVNNG 23450
Query: 1117 LNGILQGFRV-------IYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFT 1169
+ ++ G+ + I W ++ + LE+ Y +V A
Sbjct: 23451 GSPVI-GYHLERKERNSILWT--------KVNKTIIHDTQFKAQNLEEGIEYEFRVYAEN 23501
Query: 1170 RAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNG-IIRKYTVFCSH 1228
G G S+ D PP + + + + W P+ G +I Y V
Sbjct: 23502 IVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRD 23561
Query: 1229 -PYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGR----GNSSEIITVEPLAK 1283
P + + + + L+ +++Y V+A +AG +S+ IT + +
Sbjct: 23562 LPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVE 23621
Query: 1284 APARILT--FSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSN 1341
P + F T+ + L G P P ++W++ + + + F
Sbjct: 23622 LPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFK- 23680
Query: 1342 GSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR--LTVSKTTSSSITLSW 1399
I++ D G Y A+N GS +N++V P P + V+ TS +L+W
Sbjct: 23681 ALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTW 23740
Query: 1400 LPG-DNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG 1458
P +GGS I Y+++ E + W S ++ L G Y F + A N G
Sbjct: 23741 SPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYVFRIMAVNKYG 23800
Query: 1459 PGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWN----DGGCPITSFTLEYR 1514
G E A L K P + + WN DGG I + +E R
Sbjct: 23801 VGEPLE--SAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKR 23858
Query: 1515 PFGTTVWTTAQRTSLSKSYI-LYDLQEATWYELQMRVCNSAGCAE 1558
W + ++ + + L E YE ++ N+AG E
Sbjct: 23859 DRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGE 23903
Score = 87.8 bits (216), Expect = 1e-16
Identities = 170/734 (23%), Positives = 287/734 (39%), Gaps = 115/734 (15%)
Query: 802 GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSG 861
G+ ++SC G ++W + + + + +Y +S+ + TL ++ +ED G
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELI-QSRKYKMSS----DGRTHTLTVMTEEQEDEG 30601
Query: 862 FFSCHAINSYGE----DRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNS--PI 915
++C A N GE + ++Q T Q P P ++ K A TLR + + G +
Sbjct: 30602 VYTCIATNEVGEVETSSKLLLQATPQFHPGYP-LKEKYYGAVGSTLRLHVMYIGRPVPAM 30660
Query: 916 TGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEL 975
T + + ++ + + T+ + + H + Y +++ N G + ++
Sbjct: 30661 TWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTH-AGKYKVQL--SNVFGTVDAILDV 30717
Query: 976 TITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQF 1035
I + PD P + +E + S ++WK P I Y + E G +Q
Sbjct: 30718 EI---QDKPDKPTGPIVIEALLKNSAVISWKPPADD-GGSWITNYVVEKCEAKEGAEWQL 30773
Query: 1036 --NIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGP----SSQEIITTTLEDVPS 1089
+ ISV T + NL + Y V A N G SS II + E +
Sbjct: 30774 VSSAISVTTC------RIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGA 30827
Query: 1090 YPPENVQAIATSPESISISWSTLSKEALNGILQGF------RVIYWANLMDGELGE---- 1139
P A + +S ++W + + I + + W ++ E+ E
Sbjct: 30828 --PGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFS 30885
Query: 1140 IKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRT-KEDVPGPPAGVKAA 1198
+KN+ ++GLE Y +V G+ SE T K DVP K
Sbjct: 30886 VKNL--------IEGLE----YEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEE 30933
Query: 1199 AASASMVFVSWLPPLKLNGIIRKYTVFCS---HPYPTVI---SEFEASPDSFSYRIPNLS 1252
+ ++ + S T+ C HP P V E D YRI
Sbjct: 30934 LRNLNVRYQS------------NATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFK 30981
Query: 1253 -----------RNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARI---LTFSGTVTTP 1298
+ +V+ V T+ G G+ S ++E + PA+I T G
Sbjct: 30982 GGYHQLIIASVTDDDATVYQVRATNQG-GSVSGTASLE--VEVPAKIHLPKTLEGMGAVH 31038
Query: 1299 WMKDIVLPCKAV--GDPSPAVKWMK-----DSNGTPSLVTIDGRRS-IFSNGSFIIRTVK 1350
++ V+ K G P P + W K D+NG ++ S +F NG V+
Sbjct: 31039 ALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNG------VE 31092
Query: 1351 AEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSWL-PGDNGGSS 1408
+D+G+Y A N +G D+ + L V PD PR + VS + S+ L+W P +GGS
Sbjct: 31093 RKDAGFYVVCAKNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGGSK 31152
Query: 1409 IRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEA 1468
I YI++ +E+W E Y + NL T Y+F + A+N G + SE
Sbjct: 31153 ITNYIVEKCATTAERWLRVG-QARETRYTVINLFGKTSYQFRVIAENKFGLSKPSE---- 31207
Query: 1469 KTLGKEPQFSKEQE 1482
EP +KE +
Sbjct: 31208 ---PSEPTITKEDK 31218
Score = 87.4 bits (215), Expect = 1e-16
Identities = 181/834 (21%), Positives = 313/834 (37%), Gaps = 126/834 (15%)
Query: 95 IHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAY 154
I + TY S K++ + V IK L+ +D AVF +
Sbjct: 2686 IGEYTYKVATSKTSAKLKVEAVKIKKTLKNLTVTETQD--------AVFTVEL---THPN 2734
Query: 155 ITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQN----EDGLYNYRCITRHRYTGETRQS 210
+ V W K+ V L S ++ I+ G +Y ++N ++ +Y +R R
Sbjct: 2735 VKGVQWIKNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRL---------GRLG 2785
Query: 211 NSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGR 270
SARL V I+ A+ V ++ H +W ++ ++ S +
Sbjct: 2786 ASARLHVE-----TVKIIKKPKDVTALENATVAFEV-SVSHDTVPVKWFHKSVEIKPSDK 2839
Query: 271 F----QKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSS 326
++ V L+++NI PSD+G Y V G + +L+V + L T + + ++
Sbjct: 2840 HRLVSERKVHKLMLQNISPSDAGEYTAVV----GQLECKAKLFV-ETLHITKTMKNIEVP 2894
Query: 327 VGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRIT--GINHENLIMDHMVKSDGGAYQ 384
S C V+ + W +NG + + +I G H+ +IM+ + D Y
Sbjct: 2895 ETKTASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTE-DSAEYT 2952
Query: 385 CFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDD 444
D++SA V ++ K I+A + ++ + N +G + W
Sbjct: 2953 FVCGNDQVSATLTVTPIMITSMLKDINAEEKDTIT----FEVTVNYEGI---SYKW---- 3001
Query: 445 DPILKGG----SHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG-VVLYQARI 499
LK G S QM T + + LNI + D Y A + LY +
Sbjct: 3002 ---LKNGVEIKSTDKCQMRTKK--LTHSLNIRNVHFGDAADYTFVAGKATSTATLY---V 3053
Query: 500 NVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR-QVAFENNGT 558
R + +K+I + + C V P +++W K+ L R ++ E
Sbjct: 3054 EARHIEFRKHIKDIKVLEKKRAMFECEV-SEPDITVQWMKDDQELQITDRIKIQKEKYVH 3112
Query: 559 LKLSDVQKEVDEGEYTC----NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVF 614
L + D G+YT NV + V + + +Q E QR
Sbjct: 3113 RLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRIR-SIKKEVQVIE------KQRAV 3165
Query: 615 IPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHN-----GNYTC 669
+ V D + W KDG I + + + RI + + G YT
Sbjct: 3166 VEFEVNEDD--VDAHWYKDGIEINFQVQ---ERHKYVVERRIHRMFISETRQSDAGEYTF 3220
Query: 670 IARNEAAAVEHQSQLIVRVP-PKFVVQPRDQDGIY-GKAVILNCSAEGYPVPTIVWKFSK 727
+A ++V L V P P V+Q + GK G P P I W
Sbjct: 3221 VAGRNRSSV----TLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISW---- 3272
Query: 728 GAGVPQFQPIALNGRIQVLSNG---SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
+ Q ++ + + L +G +LL+ ED+ Y C+ ND G + S L+V
Sbjct: 3273 ---YKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGV-ATTSASLSV 3328
Query: 785 KIPAMITS------YP-------NTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPE 831
++P +++ YP T+ ++GQ C G + V W +D+ I P
Sbjct: 3329 EVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSG-TDLKVSWYSKDKKIKP- 3386
Query: 832 MARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEP 885
+R+ T+ E L+I ED G ++ A N+ G+ L+++ P
Sbjct: 3387 -SRFFRMTQ---FEDTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAP 3436
Score = 87.4 bits (215), Expect = 1e-16
Identities = 151/711 (21%), Positives = 267/711 (37%), Gaps = 76/711 (10%)
Query: 633 DGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRV---- 688
DGR + + + DN FT ++ LS + +A+N A + S+ V
Sbjct: 28985 DGRWLKCNYTIVSDNF-FT----VTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRD 29039
Query: 689 ---PPKFVVQPRDQDGIY----GKAVILNCSAEGYPVPTIVW-KFSKGAGVPQFQPIALN 740
PPK + R + G ++L+ + G P P I+W K K + + +
Sbjct: 29040 EYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYT 29099
Query: 741 GRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLAT 800
G+ + +IK DSG Y V N G +K++ + VK+ L +
Sbjct: 29100 GK-----RATAVIKFCDRSDSGKYTLTVKNASG---TKAVSVMVKV-----------LDS 29140
Query: 801 QGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKE-------VGEEVISTLQIL 853
G +++ + ++ + W E+ Y+V +E + E TL +
Sbjct: 29141 PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYV 29200
Query: 854 PT--VREDSGFFSCHAINSYG-----EDRGII---QLTVQEPPDPPEIEIKDVKARTITL 903
T ++ + F A+N YG E I+ T+ PP PE E+ K I +
Sbjct: 29201 VTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPE-EVGTGKEH-III 29258
Query: 904 RWTM-GFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYA 962
+WT DG + I+ Y ++ K + S + KD + + Y R+ A
Sbjct: 29259 QWTKPESDGGNEISNYLVD-KREKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTA 29317
Query: 963 KNRIGKSEPSNELTITA--DEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGY 1020
N G SEPS + + + GPP + + SI + W P I+ GY
Sbjct: 29318 VNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIV-GY 29376
Query: 1021 QIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEII 1080
+ +E T Q+ + + + + +T+ +L +Y V A N G S+ I
Sbjct: 29377 VLEMQEKDTD---QWYRVHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESI- 29432
Query: 1081 TTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANL-MDGELGE 1139
+E V +++ ++++I + ++ + VI W+ +D
Sbjct: 29433 -AEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRA 29491
Query: 1140 IKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAA 1199
I + T + L +D + +Y + A ++G +S + + D PGP VK
Sbjct: 29492 IIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGK--KSATVLVKV-YDTPGPCPSVKVKE 29548
Query: 1200 ASASMVFVSW-LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYS 1258
S V ++W +P + + Y V YRI L Y
Sbjct: 29549 VSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYY 29608
Query: 1259 VWVVAVTSAGRG---NSSEIITVEPLAKAPARILTF---SGTVTTPWMKDI 1303
V+ G G +S+ + V + PA++ TVT W K +
Sbjct: 29609 FRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPL 29659
Score = 87.0 bits (214), Expect = 2e-16
Identities = 253/1207 (20%), Positives = 431/1207 (35%), Gaps = 181/1207 (14%)
Query: 492 VVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL-PFNHRQ 550
V + + R S+ +T AG + + V G P ++ W K+ LL P +
Sbjct: 19284 VTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIK 19343
Query: 551 VAFENN-GTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSI 609
+A + N TL+L V ++ D G+YT ++S S T+K+ +P I
Sbjct: 19344 MAMQRNLCTLELFSVNRK-DSGDYTITAE-----NSSGSKSATIKLKVLDKPGPPASVKI 19397
Query: 610 GQRVFIPCVVVSGDLPIT----------ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNL 659
+++ ++S + P+ + ++ RP + T+ +S + L
Sbjct: 19398 N-KMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVP----ITSCSVEKL 19452
Query: 660 SLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVP 719
H + A N+ + V P P D G VI N + +
Sbjct: 19453 IEGHEYQFRICAENKYGVGDP-----VFTEPAIAKNPYDPPGRCDPPVISNITKDHM--- 19504
Query: 720 TIVWKFSKGAGVPQFQPIALNGR-IQVLSNGSLLIKHVVE--------EDSGYYLCKVS- 769
T+ WK G L R Q ++ + K ++E ++ Y +V+
Sbjct: 19505 TVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTA 19564
Query: 770 -NDVG----ADVSKSMYLT-VKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK 823
N G +D SK+ Y + P ++P T+ + + W K
Sbjct: 19565 INKAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSS-------------VSLSWGK 19611
Query: 824 EDRIINPEMARYLVSTKEVGEE----------VISTLQILPTVREDSGF-FSCHAINSYG 872
+ YLV K + + T + + ED+ + F +A+N G
Sbjct: 19612 PAYDGGSPIIGYLVEVKRADSDNWVRCNLPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIG 19671
Query: 873 EDRGIIQLTVQEPPD---PPEIEIKDVKARTITLRWTMGFDGNSPITGYD---------- 919
P D PPE E+ +T+ LR + P+ G
Sbjct: 19672 YSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPN 19731
Query: 920 ------IECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN 973
I KS +D+ R ++V+ + + Y + + +N GK E
Sbjct: 19732 VNLRDRIGLDIKSTDFDTFLRCENVNK----------YDAGKYILTL--ENSCGKKE--- 19776
Query: 974 ELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAP----KKHLQNGIIRGYQIGYREYST 1029
TI GPP V ++ IS S VTW+ P + N +++ + +ST
Sbjct: 19777 -YTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWST 19835
Query: 1030 GGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPS 1089
V T + + NL + Y V A N G G + P
Sbjct: 19836 ----------VTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPG 19885
Query: 1090 YPPENVQAIATSPESISISWSTLSKEALNGILQGFRVI-YWANLMDGELGEIKNITTTQP 1148
P +++ + S S SI W + G R+I Y + + E + + +
Sbjct: 19886 -PVVDLKVRSVSKSSCSIGWKKPHSDG------GSRIIGYVVDFLTEENKWQRVMKSLSL 19938
Query: 1149 SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVS 1208
L + Y+ +V A G+G SE I ++DV P +K
Sbjct: 19939 QYSAKDLTEGKEYTFRVSAENENGEGTPSE-ITVVARDDVVAPDLDLKG----------- 19986
Query: 1209 WLPPL----KLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAV 1264
LP L K N R P P+V + P + R+ S ++ V
Sbjct: 19987 -LPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDC 20045
Query: 1265 TSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM--KD 1322
+ G + IT++ +A ++ V P + + V + +KW KD
Sbjct: 20046 QKSDAGKYT--ITLKNVAGTKEGTISIK-VVGKPGIPTGPIKFDEVTAEAMTLKWAPPKD 20102
Query: 1323 SNGTPSLVTIDGRRSIFSNG---------SFIIRTVKAEDSGYYS--CIANNNWG----- 1366
G+ I +R +N R + + Y+ A N +G
Sbjct: 20103 DGGSEITNYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGL 20162
Query: 1367 -SDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWL-PGDNGGSSIRGYILQYSEDNSEQW 1424
S+ I+ VP P + S++L+W P GGS I GY L++ E NS W
Sbjct: 20163 KSEPIVARHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLW 20222
Query: 1425 GSFPISPSE-RSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQEL 1483
+P R +++ L G Y+F + A N G G+ S E + E+
Sbjct: 20223 KRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEV 20282
Query: 1484 FASINTTRVRLNLIGWN----DGGCPITSFTLEYRPFGTTVWTTAQRTSLSK-SYILYDL 1538
IN TR + LI W DGG +T + +E R + W A ++ + ++ + DL
Sbjct: 20283 ---INITRNSVTLI-WTEPKYDGGHKLTGYIVEKRDLPSKSWMKANHVNVPECAFTVTDL 20338
Query: 1539 QEATWYELQMRVCNSAGC--AEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEGLKML 1596
E YE ++R N+AG A ++ + D P ++ ++GLT G ++
Sbjct: 20339 VEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPT-IKDGLTIKAGDTIV 20397
Query: 1597 VTISCIL 1603
+ IL
Sbjct: 20398 LNAISIL 20404
Score = 87.0 bits (214), Expect = 2e-16
Identities = 123/588 (20%), Positives = 227/588 (38%), Gaps = 52/588 (8%)
Query: 219 DPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQ----KT 274
+P +S P I+ G + + KA G P P W KD + G+++ K
Sbjct: 32846 EPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKG 32905
Query: 275 VTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS 334
L I SDSG Y C V N G+ +L +K +K T +KV + S+++
Sbjct: 32906 GFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIK-AIKDT-EAQKVSTQKTSEITPQ 32963
Query: 335 CSVTGTEDQELSWYRNGEI-LNPGKNVRITGINHEN---LIMDHMVKSDGGAYQCFVRKD 390
E+ R+ EI ++ K+ + E LI + + KS + + + +
Sbjct: 32964 KKAVVQEEISQKALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHE 33023
Query: 391 KLSAQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVSLMCNVKGTPLPTITWTLDDDPILK 449
+++ Q E T I AFS ++ ++ + + L N+ G + W L+ +
Sbjct: 33024 EITKTS--QASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGA--TDVKWVLNGVELTN 33079
Query: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR-----GP 504
+R + + L I + RD G+ C + G+V Q + + P
Sbjct: 33080 SEEYRYGVSGSDQ-----TLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAP 33134
Query: 505 ASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDV 564
A I ++ G++ C + G P I+W+KN+ + + + L
Sbjct: 33135 AFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIR 33194
Query: 565 QKEV-DEGEYTCNVL-VQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSG 622
V D G+YT + Q S + S+ V +P +P + S
Sbjct: 33195 NASVSDSGKYTIKAKNFRGQCSATASLMV---LPLVEEPSREVVLRTSGDTSLQGSFSSQ 33251
Query: 623 DLPITITWQKDG-RPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQ 681
+ ++ + Q+ S ++ + F +S+ ++S M ++ ++ + + +
Sbjct: 33252 SVQMSASKQEASFSSFSSSSASSMTEMKF-ASMSAQSMSSMQE-SFVEMSSSSFMGISNM 33309
Query: 682 SQL-----------IVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAG 730
+QL I +PPK P D GK + + C+ G P P + W
Sbjct: 33310 TQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKI 33369
Query: 731 VPQFQPIALNGRIQVLSNG---SLLIKHVVEEDSGYYLCKVSNDVGAD 775
Q Q GR + + +L+I V ++D G Y + N+ G+D
Sbjct: 33370 HSQEQ-----GRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSD 33412
Score = 86.7 bits (213), Expect = 2e-16
Identities = 261/1273 (20%), Positives = 446/1273 (35%), Gaps = 236/1273 (18%)
Query: 238 AGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG--LLIENIRPSDSGSYVCEV 295
AG + L G P P W K + L T + L+++ + D+G Y E
Sbjct: 29460 AGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTIEA 29519
Query: 296 SNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILN 355
N+ G K+ KV + G S+ + ++W
Sbjct: 29520 ENQSGK-------------KSATVLVKVYDTPGPCPSVKVKEVSRDSVTITW-------- 29558
Query: 356 PGKNVRITGINHENLIMDHMVKSDGGAYQCFVR-KDKLSAQDYVQVVLEDGTPKIISAFS 414
I I+ + +++V+ A + F K S Y L +GT
Sbjct: 29559 -----EIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLP 29613
Query: 415 EKVVSPAEPVSLMCNVKGTPLPTITWTLD-------------DDPILKGGSH-------- 453
E + EP V + +P + L+ + P+ GGS
Sbjct: 29614 ENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEA 29673
Query: 454 ------RISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV----------VLYQA 497
R +++T + V+ + ++S + ++R A N GV +
Sbjct: 29674 CKAGTERWMKVVTLKPTVLEH-TVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDL 29732
Query: 498 RINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNG 557
R+ S P K I AGR + + G P + W+ + L + R +
Sbjct: 29733 RVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTK 29792
Query: 558 TLKLSDVQKEV-DEGEYTCNVLVQPQLSTSQSVHVTV--KVPPFIQPFEFPRF-SIGQRV 613
KL+ + + D GEYT L +TS+++ V + K P P + + +
Sbjct: 29793 VAKLTIRETTIRDTGEYTLE-LKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITI 29851
Query: 614 FIPCVVVSGDLPIT--ITWQKDG-RP--IPGSLGVTIDNIDFTS-------SLRISNLSL 661
+ G P++ + Q+D RP +P S VT FT R++ +
Sbjct: 29852 SWEPPELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNR 29911
Query: 662 MHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTI 721
G+Y ++ +E +S + + PP+ + I + S +G T+
Sbjct: 29912 FGIGSYL-----QSEVIECRSSIRIPGPPETL-------------QIFDVSRDGM---TL 29950
Query: 722 VWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMY 781
W + G GS + ++VE +V AD
Sbjct: 29951 TWYPPEDDG------------------GSQVTGYIVER----------KEVRAD---RWV 29979
Query: 782 LTVKIPAMITSYPNTTLATQGQKKEMSCTA----------HGEKPII------------- 818
K+P +T Y +T L T+G + E TA KPI+
Sbjct: 29980 RVNKVPVTMTRYRSTGL-TEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQN 30038
Query: 819 ------------VRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPT-VRE------- 858
+ W + ++ YL+ ++V + + PT +RE
Sbjct: 30039 PRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLP 30098
Query: 859 --DSGFFSCHAINSYG-----EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDG 911
F A N+ G E G +++T E + P+ E+ + I +R
Sbjct: 30099 QGAEYRFRVLACNAGGPGEPAEVPGTVKVT--EMLEYPDYELDERYQEGIFVRQGGVIRL 30156
Query: 912 NSPITGYDIE-CKNKSDSWDSAQRTKDVSPQLNSATII---DIHPSSTYSIRMYAKNRIG 967
PI G CK + D ++R + + ++ +I D S TY + + +N+ G
Sbjct: 30157 TIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVL--ENKCG 30214
Query: 968 KSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREY 1027
K ++ + +P+GP + + I +S+RV+W+ P I GY + RE
Sbjct: 30215 KKAVYIKVRVIGSPNSPEGP---LEYDDIQVRSVRVSWRPPADD-GGADILGYILERREV 30270
Query: 1028 STGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGP--SSQEIITTTLE 1085
+ ++D+ + L + +Y V A N+ G S+E +T
Sbjct: 30271 PKAAWY-----TIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTP 30325
Query: 1086 DVPSYPPEN-VQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIK-NI 1143
P PP N + + + S+S+SWS K+ + G+ + D + K I
Sbjct: 30326 LNPPEPPSNPPEVLDVTKSSVSLSWSR-PKDDGGSRVTGYYIERKETSTDKWVRHNKTQI 30384
Query: 1144 TTTQPSLELDGLEKYTNYSIQVLAFTRAG---DGVRSEQIFTRTKEDVPGPPAGVKAAAA 1200
TTT + GL Y +++A G SE + + D P P ++ +
Sbjct: 30385 TTTM--YTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSI 30442
Query: 1201 SASMVFVSWLPP-----LKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNR 1255
S V + W P ++ G +Y + S E D + I L
Sbjct: 30443 SKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKK--SNKERIKDK-QFTIGGLLEAT 30499
Query: 1256 QYSVWVVAVTSAG----RGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVG 1311
+Y V A G R + I T +AP I VTT + L C+ VG
Sbjct: 30500 EYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPG-IRKEMKDVTTKLGEAAQLSCQIVG 30558
Query: 1312 DPSPAVKWMKDS----NGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGS 1367
P P +KW + ++ DGR + + T + ED G Y+CIA N G
Sbjct: 30559 RPLPDIKWYRFGKELIQSRKYKMSSDGR-----THTLTVMTEEQEDEGVYTCIATNEVGE 30613
Query: 1368 DEIILNLQVQVPP 1380
E L +Q P
Sbjct: 30614 VETSSKLLLQATP 30626
Score = 86.3 bits (212), Expect = 3e-16
Identities = 179/817 (21%), Positives = 294/817 (35%), Gaps = 83/817 (10%)
Query: 786 IPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEE 845
IP NT G+ ++ G V W K++ + ST E
Sbjct: 22146 IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAEST-----E 22200
Query: 846 VISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP--EIEIKDVKARTITL 903
S L I RED G + NS GE + + V + P PP +++ +V A +ITL
Sbjct: 22201 NNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITL 22260
Query: 904 RW-TMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYA 962
W +DG S I Y +E K D+ + + + + + Y R+ A
Sbjct: 22261 SWGPPKYDGGSSINNYIVE---KRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAA 22317
Query: 963 KNRIGKSEPSN-ELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQ 1021
+NR GKS N E T+ GPP + S S+ V W P + +I GY
Sbjct: 22318 ENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVI-GYH 22376
Query: 1022 IGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIIT 1081
+ +E ++ + N T + L + +Y V A N G G S+
Sbjct: 22377 LERKERNSILWVKLN----KTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSEC 22432
Query: 1082 TTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIK 1141
D P PP +AI + S+++ W + + + G+ ++ L +G +
Sbjct: 22433 YVARD-PCDPPGRPEAIIVTRNSVTLQWKKPTYDG-GSKITGY-IVEKKELPEGRWMKAS 22489
Query: 1142 NITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAAS 1201
E+ GL + Y +V+A R GV SE P G A
Sbjct: 22490 FTNIIDTHFEVTGLVEDHRYEFRVIA--RNAAGVFSE----------PSESTGAITARDE 22537
Query: 1202 ASMVFVSWLPPLKLNGIIRKYTVF------CSHPYPTV-------------ISEFEASPD 1242
+S P K ++ F P PT+ E +++
Sbjct: 22538 VDPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDF 22597
Query: 1243 SFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKD 1302
+ S + + R + + A AG + + + V P + SG
Sbjct: 22598 ATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLA 22657
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLV--TIDGRRSIFSNGSFIIRTVKAEDSGYYS-- 1358
P + G S + ++ + T LV +D S + K + Y+
Sbjct: 22658 WKPPLQDGG--SDIINYIVERRETSRLVWTVVDANVQTLS-----CKVTKLLEGNEYTFR 22710
Query: 1359 CIANNNWG------SDEIILNLQVQVPPDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRG 1411
+A N +G S+ ++ VP V+ T S+ + W P +GGS I G
Sbjct: 22711 IMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILG 22770
Query: 1412 YILQYSEDNSEQW-GSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRISEIIE 1467
Y+L+ + +W E R+ L Y+F ++A+N G P S +
Sbjct: 22771 YVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQK 22830
Query: 1468 AKTLGKEPQFSKEQELFASINTTRVRLNLIGWN----DGGCPITSFTLEYRPFGTTVWT- 1522
A +P ++ I+ TR + + W+ DGGC I + +E WT
Sbjct: 22831 ACDPIYKPGPPNNPKV---IDITRSSV-FLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTM 22886
Query: 1523 TAQRTSLSKSYI-LYDLQEATWYELQMRVCNSAGCAE 1558
T ++K+ I + L E Y ++ N AG E
Sbjct: 22887 CTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGE 22923
Score = 85.1 bits (209), Expect = 6e-16
Identities = 187/854 (21%), Positives = 319/854 (37%), Gaps = 99/854 (11%)
Query: 688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLS 747
+PP F + + G+ + ++ G P P + W VP Q +N +
Sbjct: 22146 IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDN---VPLKQTTRVNAE-STEN 22201
Query: 748 NGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEM 807
N L IK ED G+Y+ K++N G + + + P T G K
Sbjct: 22202 NSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPT----------GPVKMD 22251
Query: 808 SCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGE---EVISTLQILPTV---REDSG 861
TA I + W + Y+V ++ +++S T+ R +G
Sbjct: 22252 EVTADS---ITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATVARTTIKACRLKTG 22308
Query: 862 F---FSCHAINSYGEDRGIIQ--LTVQEP---PDPPEIEIKDVKAR-TITLRWTMGF-DG 911
F A N YG+ + Q P P PP + + +R ++ ++W DG
Sbjct: 22309 CEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWNEPISDG 22368
Query: 912 NSPITGYDIECKNK-SDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSE 970
S + GY +E K + S W +T PQ T + Y R+ A+N +G +
Sbjct: 22369 GSRVIGYHLERKERNSILWVKLNKTP--IPQTKFKT-TGLEEGVEYEFRVSAENIVGIGK 22425
Query: 971 PS--NELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYS 1028
PS +E + D P G P+ + ++ S+ + WK P + I GY + +E
Sbjct: 22426 PSKVSECYVARDPCDPPGRPEAI---IVTRNSVTLQWKKP-TYDGGSKITGYIVEKKELP 22481
Query: 1029 TGGNFQFNIIS-VDTSGDSEVYTLDNLNKFTQYGLVVQACNRAG--TGPSSQEIITTTLE 1085
G + + + +DT + + L + +Y V A N AG + PS T +
Sbjct: 22482 EGRWMKASFTNIIDTH-----FEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARD 22536
Query: 1086 DVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITT 1145
+V P + ++I + K + + I W D EL +
Sbjct: 22537 EV---DPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIK-GDQEL-------S 22585
Query: 1146 TQPSLELDGLEKYTNYSIQVLAFTRAGD---------GVRSEQIFTRTKEDVPGPPAG-V 1195
LE+ + T+ S++ +G+ G RS + + D PGPP G V
Sbjct: 22586 NTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVL-DRPGPPEGPV 22644
Query: 1196 KAAAASASMVFVSWLPPLKLNGI-IRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRN 1254
+ +A ++W PPL+ G I Y V V + +A+ + S ++ L
Sbjct: 22645 VISGVTAEKCTLAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEG 22704
Query: 1255 RQYSVWVVAVTSAGRG---NSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVG 1311
+Y+ ++AV G G S ++ P A TVT M +V A
Sbjct: 22705 NEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSM-IVVWERPASD 22763
Query: 1312 DPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEII 1371
S + ++ + + + + + + + A N G E
Sbjct: 22764 GGSEILGYVLEKRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPS 22823
Query: 1372 LNLQVQV---------PPDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNS 1421
Q PP+ P+ V T SS+ LSW P +GG I+GYI++ + +
Sbjct: 22824 PPSAYQKACDPIYKPGPPNNPK--VIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSV 22881
Query: 1422 EQWG--SFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISE-----IIEAKTLGKE 1474
+W + P ++ + +E L Y F + A N G G ++ I+E K +
Sbjct: 22882 GEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKL--EA 22939
Query: 1475 PQFSKEQELFASIN 1488
P + EL IN
Sbjct: 22940 PDIDLDLELRKIIN 22953
Score = 84.7 bits (208), Expect = 8e-16
Identities = 268/1202 (22%), Positives = 430/1202 (35%), Gaps = 179/1202 (14%)
Query: 258 WLKDNMPLELSGRFQKTVTG----LLIENIRPSDSGSY--VCEVSNRYGTAKVIGRLYVK 311
WLK+ + +E+S +F+ V G L+I N DS Y VC G +V L V
Sbjct: 2914 WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVC------GNDQVSATLTVT 2967
Query: 312 QPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNG-EILNPGK-NVRITGINHEN 369
P+ T + + + ++ +V E W +NG EI + K +R + H +
Sbjct: 2968 -PIMITSMLKDINAEEKDTITFEVTVN-YEGISYKWLKNGVEIKSTDKCQMRTKKLTH-S 3024
Query: 370 LIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCN 429
L + ++ D Y K +A YV+ + I + V + C
Sbjct: 3025 LNIRNVHFGDAADYTFVAGKATSTATLYVEARHIEFRKHI----KDIKVLEKKRAMFECE 3080
Query: 430 VKGTPLPTITWTLDDDPILKGGSHRISQMIT-SEGNVVSYLNISSSQVRDGGVYRCTANN 488
V P T+ W DD + +I+ I + V L I S+++ D G Y A
Sbjct: 3081 VS-EPDITVQWMKDDQEL------QITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGG 3133
Query: 489 SAGVVLYQARINVRG-PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFN 547
+ A++ V G IR +K + + + + WYK+ + F
Sbjct: 3134 NVST----AKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQ 3189
Query: 548 ----HRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPP-FIQPF 602
H+ V + +S+ ++ D GEYT V + +S +++V PP +Q
Sbjct: 3190 VQERHKYVVERRIHRMFISETRQS-DAGEYT---FVAGRNRSSVTLYVNAPEPPQVLQEL 3245
Query: 603 EFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLM 662
+ G+ C V+SG I+W K+ + + + +L +
Sbjct: 3246 QPVTVQSGKPARF-CAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPE 3304
Query: 663 HNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVIL----NCSAEGYP- 717
YTC A+N+ + L V VP VV P + +Y A+I ++EG P
Sbjct: 3305 DAAVYTCEAKNDYGVATTSASLSVEVPE--VVSPDQEMPVYPPAIITPLQDTVTSEGQPA 3362
Query: 718 -----VPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDV 772
V K S + + +P Q L I ED G Y SN V
Sbjct: 3363 RFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASNAV 3422
Query: 773 GADVSKSMYLTVKIPA-------------------MITSYPNTTLATQGQKKEMSCTAHG 813
G VS + L+++ P +I G + +C
Sbjct: 3423 G-QVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQS 3481
Query: 814 EKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGE 873
+ +W K R I + S+K IS+L+IL T D G ++C A N YG
Sbjct: 3482 APNVRFQWFKAGREIYESDKCSIRSSK-----YISSLEILRTQVVDCGEYTCKASNEYGS 3536
Query: 874 DRGIIQLTVQE--PPD----PPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSD 927
LTV E PP P + KA T G I D + S
Sbjct: 3537 VSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVT-GTPVIETIWQKDGAALSPSP 3595
Query: 928 SWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITAD------- 980
+W + +L++ TI D YS + A N+ G EL I
Sbjct: 3596 NWRISDAENKHILELSNLTIQD---RGVYSCK--ASNKFGADICQAELIIIDKPHFIKEL 3650
Query: 981 EAAPDGPPQEVHLE--PISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNII 1038
E ++VHLE + + VTW + L G + Y+I +
Sbjct: 3651 EPVQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPG--KDYKICF-------------- 3694
Query: 1039 SVDTSGDSEVYTLD-NLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQA 1097
+ ++ TL+ L K G V C + SS T T+ + PS+
Sbjct: 3695 ------EDKIATLEIPLAKLKDSGTYV--CTASNEAGSSSCSATVTVREPPSF------- 3739
Query: 1098 IATSPESISISWSTLSKEA--LNGILQGFRVIY--WANLMDGELGEIKNI----TTTQPS 1149
+ + S+ L E+ L+ L+G VI W + EL E + ++
Sbjct: 3740 ----VKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFK-NNKELSESNTVRMYFVNSEAI 3794
Query: 1150 LELDGLEKYTNYSIQVLAFTRAGDGVRSEQI-------FTRTKEDVPGPPAGVKAAAASA 1202
L++ ++ + S A G S +I F +T E PA + +
Sbjct: 3795 LDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLE-----PADIVRGTNAL 3849
Query: 1203 SMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVV 1262
VS P +++ K + S Y + + FS+ ++ +Y VV
Sbjct: 3850 LQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVG---EYEC-VV 3905
Query: 1263 AVTSAGRGNSSEIITVEP--LAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWM 1320
A G + + EP K ++ G T L G +V WM
Sbjct: 3906 ANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVT-------LQAAVRGSEPISVTWM 3958
Query: 1321 KDSNGTPSLVTIDGR-RSIFSNG--SFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQ 1377
K ++ DG+ + FSNG II V+ G Y+C+A N GS + L V+
Sbjct: 3959 KGQ----EVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVK 4014
Query: 1378 VP 1379
P
Sbjct: 4015 EP 4016
Score = 82.4 bits (202), Expect = 4e-15
Identities = 104/440 (23%), Positives = 175/440 (39%), Gaps = 33/440 (7%)
Query: 666 NYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVW-K 724
N T ++R A+ +++L P + +D G+A L+C G P+P I W +
Sbjct: 30509 NETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYR 30568
Query: 725 FSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
F K + ++ +GR L+ + +ED G Y C +N+VG + S L
Sbjct: 30569 FGKELIQSRKYKMSSDGRTHTLT-----VMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ 30623
Query: 785 KIPAMITSYP--NTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEV 842
P YP G + G + W +++ + +T+
Sbjct: 30624 ATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHY 30683
Query: 843 GEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP--EIEIKDVKART 900
V+ +Q + +G + N +G I+ + +Q+ PD P I I+ + +
Sbjct: 30684 THLVMKNVQ----RKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNS 30739
Query: 901 ITLRW-TMGFDGNSPITGYDIE-CKNKSDS-WDSAQRTKDVSPQLNSATIIDIHPSSTYS 957
+ W DG S IT Y +E C+ K + W V+ + I+++ ++ Y
Sbjct: 30740 AVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVT----TCRIVNLTENAGYY 30795
Query: 958 IRMYAKNRIGKSEP--SNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNG 1015
R+ A+N G S+P + + I G P + + ++ S V WK P
Sbjct: 30796 FRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASD-GGA 30854
Query: 1016 IIRGYQIGYREYSTGGNFQFNIISVDTSGDSE-VYTLDNLNKFTQYGLVVQACNRAGTGP 1074
IR Y + RE Q ISV T E V+++ NL + +Y V+ N G
Sbjct: 30855 KIRNYYLEKREKK-----QNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESE 30909
Query: 1075 SSQ--EIITTTLEDVPSYPP 1092
S+ E IT DVP P
Sbjct: 30910 WSEISEPITPK-SDVPIQAP 30928
Score = 81.6 bits (200), Expect = 7e-15
Identities = 216/1024 (21%), Positives = 367/1024 (35%), Gaps = 150/1024 (14%)
Query: 328 GSQVSLSCSVTGTEDQELSWYRN-GEILNPGKNVRIT-GINHENLIMDHMVKSDGGAYQC 385
G + G E++W R GE + V+I G+N+ L +D+ ++D G Y
Sbjct: 24039 GGSARIHIPFKGRPTPEITWSREEGEFTD---KVQIEKGVNYTQLSIDNCDRNDAGKYIL 24095
Query: 386 FVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDD 445
+ S +V V + D +P P +L + W +
Sbjct: 24096 KLENSSGSKSAFVTVKVLD--------------TPGPPQNLAVKEVRKDSAFLVW---EP 24138
Query: 446 PILKGGSHRISQMITS-EGNVVSYLNISSS---------QVRDGGVY--RCTANNSAGVV 493
PI+ GG+ + +I E +Y N+SS + +G +Y R A N GV
Sbjct: 24139 PIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVG 24198
Query: 494 LYQARINV---------RGPASIRPMKNITAIAGRDTYIH---CRVIGY-----PYYSIK 536
+ ++ G ++ + +A + H RV+GY P + K
Sbjct: 24199 VPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEK 24258
Query: 537 WYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVP 596
W + N V ++G V+ ++G+ VL P ++ ++ ++K+P
Sbjct: 24259 WSIVAESKVCN-AVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLP 24317
Query: 597 PFIQPFEFPRFSI--GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSL 654
F +SI G+ + I V+ P I+W KDG P+ + V ++ ++ L
Sbjct: 24318 -------FNTYSIQAGEDLKIEIPVIGRPRP-NISWVKDGEPLKQTTRVNVEETATSTVL 24369
Query: 655 RISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAE 714
I + G YT A N A +IV P V P D + V+++
Sbjct: 24370 HIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPP 24429
Query: 715 GYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGA 774
Y G Q + R + ++ V K +
Sbjct: 24430 AY------------TGGCQISNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQF 24477
Query: 775 DV------SKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRII 828
+ KS L K A+I YP G T+ + ++V+W +
Sbjct: 24478 RIFAENRYGKSAPLDSK--AVIVQYP---FKEPGPPGTPFVTSISKDQMLVQWHEPVNDG 24532
Query: 829 NPEMARYLVSTKEVGEEVISTLQILP-------TVREDSGF-----FSCHAINSYGEDRG 876
++ Y + KE + L P T D G S I G+
Sbjct: 24533 GTKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSK 24592
Query: 877 IIQLTV-QEPPDPP-EIEIKDVKARTITLRWTM-GFDGNSPITGYDIECKNKSDS-WDSA 932
+ + V ++P DPP E + +TL+W +DG S ITGY +E K+ D W A
Sbjct: 24593 VSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKA 24652
Query: 933 QRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGK-SEPSNELTITADEAAPDGPPQEV 991
T + + + +++ Y R+ A+N G SEPS+ D P
Sbjct: 24653 SFTNVLETEFTVSGLVE---DQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAP--NA 24707
Query: 992 HLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTL 1051
L+P I V A + + IRG I +S G +T+ E+ +
Sbjct: 24708 SLDPKYKDVIVV--HAGETFVLEADIRGKPIPDVVWSKDGK-----ELEETAARMEIKS- 24759
Query: 1052 DNLNKFTQYGLVVQACNR----------AGTGPSSQEIITTTLEDVPSYPPENVQAIATS 1101
+ K T LVV+ C R + G + IT + D P P ++ +
Sbjct: 24760 -TIQKTT---LVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVT 24815
Query: 1102 PESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLE-KYT- 1159
E ++W+ ++ G + ++ E E ++ TQ S E+ L K T
Sbjct: 24816 AEKCYLAWNPPLQDG------GANISHYII----EKRETSRLSWTQVSTEVQALNYKVTK 24865
Query: 1160 -----NYSIQVLAFTRAGDG--VRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPP 1212
Y +V+A + G G + S + PGPP+ + +A + + V+W P
Sbjct: 24866 LLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARP 24925
Query: 1213 LKLNGIIRKYTVFCSHPYPTV--ISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRG 1270
+ G + + V + + R+ L+ Y V A +AG G
Sbjct: 24926 VDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVG 24985
Query: 1271 NSSE 1274
SE
Sbjct: 24986 EPSE 24989
Score = 81.3 bits (199), Expect = 9e-15
Identities = 254/1330 (19%), Positives = 470/1330 (35%), Gaps = 205/1330 (15%)
Query: 333 LSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKL 392
L ++ G + E+ W + IL + +T + L++D++ + D G Y + +
Sbjct: 25127 LFVTIKGRPEPEVKWEKAEGILTDRAQIEVTS-SFTMLVIDNVTRFDSGRYNLTLENNSG 25185
Query: 393 SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 452
S +V V + D SP+ PV+L T++W + P++ GG+
Sbjct: 25186 SKTAFVNVRVLD--------------SPSAPVNLTIREVKKDSVTLSW---EPPLIDGGA 25228
Query: 453 HRISQMITS-EGNVVSYLNISSS---------QVRDGGVY--RCTANNSAGVVLYQARIN 500
+ ++ E +Y I+++ +++G Y R A+N G+ L A
Sbjct: 25229 KITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGL-PAETT 25287
Query: 501 VRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK--NSNLLPFNHRQVAFENNGT 558
S P+ GR T + + +IKW K + V + G+
Sbjct: 25288 EPVKVSEPPLP-----PGRVTLVD---VTRNTATIKWEKPESDGGSKITGYVVEMQTKGS 25339
Query: 559 LKLSD-VQKEVDEG---------EYTCNVLVQPQLSTSQSVHVTV-------KVPPFIQP 601
K S Q + E EY V + S + V ++ P ++
Sbjct: 25340 EKWSTCTQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVE- 25398
Query: 602 FEFPRFSIGQRVFIPC-VVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLS 660
F F++ R + V G T+ W+KDG+ + + V + + +SL I S
Sbjct: 25399 LPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEAS 25458
Query: 661 LMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPT 720
G Y N A ++ +IV D+ G G I S + T
Sbjct: 25459 KEDVGTYELCVSNSAGSITVPITIIV----------LDRPGPPGPIRIDEVSCDSI---T 25505
Query: 721 IVWKFSKGAGVPQFQPIALNGR----------IQVLSNGSLLIKHVVEEDSGYYLCKVSN 770
I W + G Q + + Q ++ S+ I + + N
Sbjct: 25506 ISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVCAEN 25565
Query: 771 DVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINP 830
G KS Y + A++ YP + G K + T + ++V W+
Sbjct: 25566 RYG----KSSY--SESSAVVAEYPFSPPGPPGTPKVVHAT---KSTMLVTWQVPVNDGGS 25616
Query: 831 EMARYLVSTKEVGEEVIS---TLQILPTVREDSGF-------FSCHAINSYGE---DRGI 877
+ Y + KE + S + I T + SG + +A N G +
Sbjct: 25617 RVIGYHLEYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSC 25676
Query: 878 IQLTVQEPPDPP-EIEIKDVKARTITLRWTM-GFDGNSPITGYDIECKNKSDS-WDSAQR 934
+ ++P DPP + E+ ++ ++++L+W+ +DG + ITGY +E + D W
Sbjct: 25677 EPVPARDPCDPPGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNY 25736
Query: 935 TKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGK-SEPSNEL--TITADEAAPDGPPQEV 991
T + Q + ++ Y R++A+N SEPS I D+ P +V
Sbjct: 25737 T---NIQETYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDV 25793
Query: 992 HLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTL 1051
+ + KA + N I G + ++ G I ++ +E+ +
Sbjct: 25794 KFRDV------IVVKAGEVLKINADIAGRPLPVISWAKDG------IEIEERARTEIIST 25841
Query: 1052 DNLNKFTQYGLVVQACNRAGTGP----------SSQEIITTTLEDVPSYPPENVQAIATS 1101
DN T V+ C R TG + + + D P P ++ +
Sbjct: 25842 DNHTLLT-----VKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLT 25896
Query: 1102 PESISISWSTLSKEALNGILQGFRVIYWA-----------NLMDGELGEIKNITTTQPSL 1150
E S+SW ++ G + Y+ + +GEL S
Sbjct: 25897 AEKCSLSWGRPQEDG------GADIDYYIVEKRETSHLAWTICEGEL--------QMTSC 25942
Query: 1151 ELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKE--DVPGPPAGVKAAAASASMVFVS 1208
++ L K Y +V + G G E + + + VP PP ++ + + + +
Sbjct: 25943 KVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLC 26002
Query: 1209 WLPPLKLNGI-IRKYTVFCSHPYPTVISEFEASPDSFSYRIPN--LSRNRQYSVWVVAVT 1265
W P G I Y + P + R+ + L +Y V A
Sbjct: 26003 WSRPESDGGSEISGYIIERREKNSLRWVRVNKKP-VYDLRVKSTGLREGCEYEYRVYAEN 26061
Query: 1266 SAGRGNSSEIITVEPLAKA------------PARILTFSGTVTTPWMKDIVLPCKAVGDP 1313
+AG SE PL +A P + + T+T W+K + +
Sbjct: 26062 AAGLSLPSE---TSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGY 26118
Query: 1314 SPAVKWMKDSNGTPSLVTIDGRR----SIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDE 1369
+ K D++ S+ ++ G + + ++ R G ++ + SD
Sbjct: 26119 TVEYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVG----ASDPSDSSDP 26174
Query: 1370 IILNLQVQVP----PDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWG 1425
I + + P + R T+ +S T++ +P G + + + +
Sbjct: 26175 QIAKEREEEPLFDIDSEMRKTLIVKAGASFTMT-VP--FRGRPVPNVLWSKPDTDLRTRA 26231
Query: 1426 SFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFA 1485
+ S S +EN K+TLT QN + ++ +++ P Q++
Sbjct: 26232 YVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDV-- 26289
Query: 1486 SINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYE 1545
+ V + NDGG P+ ++ +E R W + SY + +LQE Y
Sbjct: 26290 -TKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYY 26348
Query: 1546 LQMRVCNSAG 1555
++ N G
Sbjct: 26349 FRVSGENEFG 26358
Score = 77.8 bits (190), Expect = 1e-13
Identities = 144/657 (21%), Positives = 249/657 (37%), Gaps = 62/657 (9%)
Query: 971 PSNELTITADEAAPD--GPPQEVHLEPISSQSIRVTWKAPKKHLQNG--IIRGYQIGYRE 1026
P+ T++ D GPP+++ + I S +TWK P L +G +I Y + R+
Sbjct: 17294 PAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEP---LDDGGSVITNYVVERRD 17350
Query: 1027 YSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLED 1086
++ Q++ +S + S + +LN+ QY V A N+ G GP + D
Sbjct: 17351 VASA---QWSPLSATSKKKS--HFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALD 17405
Query: 1087 V--PSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNIT 1144
P PP+++ + +S+ W+ ++ + I G+ V Y +G IK T
Sbjct: 17406 PLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPIT-GYLVEYQE---EGTQDWIKFKT 17461
Query: 1145 TTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASM 1204
T + GL++ Y +V A G G+ I +E + P + +
Sbjct: 17462 VTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLV 17521
Query: 1205 VFVSWLPPLKLNGIIRKYTVFCSHPYPTVI-----------SEFEASPDSFS--YRIPNL 1251
V K +R + P PT + D+FS I N
Sbjct: 17522 V--------KAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNC 17573
Query: 1252 SRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVG 1311
R + +AG + +TV + P + VT M P K G
Sbjct: 17574 LRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILD-VTPEHMTISWQPPKDDG 17632
Query: 1312 DPSPAVKWM-------KDSNGTPSLVTIDGRRSI--FSNGSFIIRTVKAEDSGYYSCIAN 1362
SP + ++ KD+ G S + + I G + V+AE+
Sbjct: 17633 G-SPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENK----IGVG 17687
Query: 1363 NNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNS 1421
S + + P + V+ T ++ T+SW LP +GGS I GY ++ E
Sbjct: 17688 PPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGYYMERREVTG 17747
Query: 1422 EQWGSFPISP-SERSYRLENLKCGTWYKFTLTAQNGVG---PGRISEIIEAKTLGKEPQF 1477
+ W +P ++ +R+ L G Y+F + A+N G P S+ I+A K P
Sbjct: 17748 K-WVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGP 17806
Query: 1478 SKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSK--SYIL 1535
+L T + +DGG PI + +E + GT W + L + ++ +
Sbjct: 17807 PINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRV 17866
Query: 1536 YDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEG 1592
L E Y +++ N G E + ++ PP ++ V + +T G
Sbjct: 17867 PGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVG 17923
Score = 74.7 bits (182), Expect = 8e-13
Identities = 203/997 (20%), Positives = 352/997 (35%), Gaps = 165/997 (16%)
Query: 302 AKVIGRLYVKQPLKAT-----ISPRKVKS-SVGSQVSLSCSVTGTEDQELSWYRNGEILN 355
A V G + V++ L+A + RK+ + G + L + G E+ W + +
Sbjct: 22925 ADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIR 22984
Query: 356 PGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSE 415
+ +T + +L++D++ + D G Y + + +V V + D
Sbjct: 22985 DAAIIDVTS-SFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLD----------- 23032
Query: 416 KVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITS-EGNVVSYLNISSS 474
+P+ PV+L +ITW + P+L GGS + ++ E SY + ++
Sbjct: 23033 ---TPSPPVNLKVTEITKDSVSITW---EPPLLDGGSKIKNYIVEKREATRKSYAAVVTN 23086
Query: 475 ---------QVRDGGVY--RCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYI 523
Q+++G Y R TA N G+ L PA + + I
Sbjct: 23087 CHKNSWKIDQLQEGCSYYFRVTAENEYGIGL---------PAQTADPIKVAEVPQPPGKI 23137
Query: 524 HCRVIGYPYYSIKWYK-----NSNLLPF------NHRQVAFENNGTLKLSDVQKEVDEGE 572
+ S+ W K S ++ + H + E L V + +GE
Sbjct: 23138 TVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVKSLQAVITNLTQGE 23197
Query: 573 -YTCNVLVQPQLSTSQSVHVTVKVPP---FIQPFEFPRFS-----IGQRVFIPCVVVSGD 623
Y V+ + S + V + I+P P FS +GQ + I V +SG
Sbjct: 23198 EYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIE-VPISGR 23256
Query: 624 LPITITWQKDGRPIPGSLGVTI-DNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQS 682
TITW KDG P+ + + + D++D T +L I G Y N
Sbjct: 23257 PKPTITWTKDGLPLKQTTRINVTDSLDLT-TLSIKETHKDDGGQYGITVANVVGQKTASI 23315
Query: 683 QLIVRVPPKFVVQPRDQDGIYGKAVILN---------CSAEGYPV-----PTIVWKFSKG 728
+++ P P D + +++ L+ C Y V T VW
Sbjct: 23316 EIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSA 23375
Query: 729 AGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVS-KSMYLTVKIP 787
++ +L + + + N G + +S + + P
Sbjct: 23376 ----------------TVARTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYP 23419
Query: 788 AMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVI 847
P T AT K M +++W + + Y + KE I
Sbjct: 23420 YKEPGPPGTPFATAISKDSM----------VIQWHEPVNNGGSPVIGYHLERKE--RNSI 23467
Query: 848 STLQILPTVREDSGF------------FSCHAINSYGEDRGIIQ---LTVQEPPDPPEI- 891
++ T+ D+ F F +A N G + ++P DPP
Sbjct: 23468 LWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDPPGTP 23527
Query: 892 EIKDVKARTITLRWTMG-FDGNSPITGYDIECKNKSDS-WDSAQRTKDVSPQLNSATIID 949
E VK ITL+WT +DG S ITGY +E ++ D W A T + Q T+
Sbjct: 23528 EPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQF---TVSG 23584
Query: 950 IHPSSTYSIRMYAKNRIGK-SEPSNELTITADEAAPDGPPQEVHLEPISSQ---SIRVTW 1005
+ Y R+ AKN G S+PS D P EV L IS +
Sbjct: 23585 LTEDQRYEFRVIAKNAAGAISKPS-------DSTGPITAKDEVELPRISMDPKFRDTIVV 23637
Query: 1006 KAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLD--------NLNKF 1057
A + + G + E+ G ++ S E+ D + +
Sbjct: 23638 NAGETFRLEADVHGKPLPTIEWLRGDK------EIEESARCEIKNTDFKALLIVKDAIRI 23691
Query: 1058 TQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEAL 1117
+++A N AG S + + D P P VQ + E S++WS ++
Sbjct: 23692 DGGQYILRASNVAG---SKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGG 23748
Query: 1118 NGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDG--V 1175
+ I + + + + +T SL++ L + Y +++A + G G +
Sbjct: 23749 SDISHYVVEKRETSRLAWTVVASEVVTN---SLKVTKLLEGNEYVFRIMAVNKYGVGEPL 23805
Query: 1176 RSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPP 1212
S + + +PGPP ++ + + V W P
Sbjct: 23806 ESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRP 23842
Score = 74.7 bits (182), Expect = 8e-13
Identities = 190/927 (20%), Positives = 323/927 (34%), Gaps = 152/927 (16%)
Query: 704 GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSG 762
G ++ L + +G P PT VW ++L I + S L +++ D+G
Sbjct: 28372 GASIRLFIAYQGRPTPTAVWSKPDSN-------LSLRADIHTTDSFSTLTVENCNRNDAG 28424
Query: 763 YYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWE 822
Y V N+ G SKS+ TVK+ L T G ++ + W+
Sbjct: 28425 KYTLTVENNSG---SKSITFTVKV-----------LDTPGPPGPITFKDVTRGSATLMWD 28470
Query: 823 KEDRIINPEMARYLVSTKEVGE---EVIS---TLQILPTVREDSG---FFSCHAINSYGE 873
+ Y+V +E +VIS T QI G +F A+N YG
Sbjct: 28471 APLLDGGARIHHYVVEKREASRRSWQVISEKCTRQIFKVNDLAEGVPYYFRVSAVNEYGV 28530
Query: 874 DRGIIQ----LTVQEPPDPPEIEIKDVKARTITLRWTM-GFDGNSPITGYDIECKNK-SD 927
+ ++P P +++ D + L W DG S ITGY +E + K SD
Sbjct: 28531 GEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDGGSRITGYLLEMRQKGSD 28590
Query: 928 SWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN----------ELTI 977
W A TK + + T+ + + Y R+ AKN G SEP ++
Sbjct: 28591 FWVEAGHTKQL-----TFTVERLVEKTEYEFRVKAKNDAGYSEPREAFSSVIIKEPQIEP 28645
Query: 978 TAD--------EAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYST 1029
TAD G P + + + +VTWK + L+
Sbjct: 28646 TADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLK---------------- 28689
Query: 1030 GGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPS 1089
+ + +S+ T+ D T+ + + + N AG S +T + P
Sbjct: 28690 ----ETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFS---VTVVVIGRPG 28742
Query: 1090 YPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPS 1149
++ + S ES +SW + G + I ++ N + +
Sbjct: 28743 PVTGPIEVSSVSAESCVLSW---GEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQ 28799
Query: 1150 LELDGLEKYTNYSIQVLAFTRAG--DGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFV 1207
+++ L KY YS +V + R G + S I P P + SA+ + +
Sbjct: 28800 IKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSI 28859
Query: 1208 SWLPPLKLNG--IIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVT 1265
W P G II + + E + +Y++ L +Y A+
Sbjct: 28860 RWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYALN 28919
Query: 1266 SAGRGNSSEI---ITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKD 1322
+AG +SE I + AP R T +T ++ A S V ++ +
Sbjct: 28920 AAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRST---VSLIWSAPAYDGGSKVVGYIIE 28976
Query: 1323 SNGTPSLVTIDGR-----RSIFSNGSFIIRTVKAEDSGYYSCIANN-----NWGSDEI-I 1371
P DGR +I S+ F + + D+ + +A N + GS+
Sbjct: 28977 RK--PVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGP 29034
Query: 1372 LNLQVQVPPDQPRL-------TVSKTTSSSITLS------------WLPGDNGGSSIRGY 1412
+ + + P + L V+ S + L W GD
Sbjct: 29035 VTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKV 29094
Query: 1413 ILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLG 1472
LQY+ + + I +RS K+TLT +N G +S ++ K L
Sbjct: 29095 SLQYTGKRA----TAVIKFCDRS---------DSGKYTLTVKNASGTKAVSVMV--KVLD 29139
Query: 1473 KEPQFSKEQELFASINTTRVRLNLIGWN----DGGCPITSFTLEYRPFGTTVWTTAQRTS 1528
K +++ + W+ DGG IT + +E R W +
Sbjct: 29140 SPGPCGK-----LTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIVEGEC 29194
Query: 1529 LSKSYILYDLQEATWYELQMRVCNSAG 1555
+ SY++ L + Y ++R N G
Sbjct: 29195 PTLSYVVTRLIKNNEYIFRVRAVNKYG 29221
Score = 74.3 bits (181), Expect = 1e-12
Identities = 145/698 (20%), Positives = 258/698 (36%), Gaps = 99/698 (14%)
Query: 258 WLKDNMPLELSGRFQKTVTG-----LLIENIRPSDSGSYVCEVSNRYGTAKV----IGRL 308
W KD L+ +G FQ + L I N+ SD G YVCE+S GT+K +G+
Sbjct: 32751 WYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQA 32810
Query: 309 YV-------------KQPLKATISP--RKVKSSVGSQVSLS-CSVTGTEDQELS------ 346
+ K K T S RK + +S VTG +D +S
Sbjct: 32811 FKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAK 32870
Query: 347 --------------WYRNGEILNPGKNVRITGINHENLIMDHMVK-SDGGAYQCFVRKDK 391
W ++G+ + G +++ + H SD G Y C V+
Sbjct: 32871 FAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSA 32930
Query: 392 LSAQDYVQVVLE---DGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDP-- 446
S ++ ++ D + +S ++P + + + L + + +
Sbjct: 32931 GSVSSSCKLTIKAIKDTEAQKVSTQKTSEITPQKKAVVQEEISQKALRSEEIKMSEAKSQ 32990
Query: 447 ---ILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG 503
LK + ++ +I+ E + ++ S V + T + QA VR
Sbjct: 32991 EKLALKEEASKV--LISEEVKKSAATSLEKSIVHE----EITKTS-------QASEEVRT 33037
Query: 504 PASIRPMKNITAI-AGRDTYIHCRVIGYPYYSIKWYKNSNLLPFN--HRQVAFENNGTLK 560
A I+ +I G+ + + G +KW N L + +R ++ TL
Sbjct: 33038 HAEIKAFSTQMSINEGQRLVLKANIAGAT--DVKWVLNGVELTNSEEYRYGVSGSDQTLT 33095
Query: 561 LSDVQKEVDEGEYTC-----NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFI 615
+ DEG TC +V+ Q + S ++ P FI + GQ V
Sbjct: 33096 IKQASHR-DEGILTCISKTKEGIVKCQYDLTLSKELS-DAPAFISQPRSQNINEGQNVLF 33153
Query: 616 PCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEA 675
C + SG+ I W K+ PI S V+I SL I N S+ +G YT A+N
Sbjct: 33154 TCEI-SGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFR 33212
Query: 676 AAVEHQSQL----IVRVPPKFVVQPRDQD----GIYGKAVILNCSAEGYPVPTIVWKFSK 727
+ L +V P + VV D G + + SA + S
Sbjct: 33213 GQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSFSSQSV-QMSASKQEASFSSFSSSS 33271
Query: 728 GAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVK-I 786
+ + + + +++ + S S+ V S + + + SK + ++ I
Sbjct: 33272 ASSMTEMKFASMSAQ----SMSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGI 33327
Query: 787 PAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINP-EMARYLVSTKEVGEE 845
P I + P+ +G+ ++C GE V W R I+ E R+ + +
Sbjct: 33328 PPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDD--- 33384
Query: 846 VISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQ 883
++TL I+ ++D G ++ N +G D + + ++
Sbjct: 33385 -LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421
Score = 73.9 bits (180), Expect = 1e-12
Identities = 204/922 (22%), Positives = 351/922 (38%), Gaps = 126/922 (13%)
Query: 52 PPVTLRWYLATGEEI-----YDVPGIRHVHPNGTLQIFPFPPSSFS-TLIHDNTYYCTAE 105
P V ++WY G E+ Y + R VH L I +S L+ D TA+
Sbjct: 2201 PFVKVKWY-KDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVKTTAK 2259
Query: 106 NPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCII-PSSVEAYITVVSWEKDT 164
+ ++ + E + ++D + +CI+ P ++E W +
Sbjct: 2260 ----------LIVEGAVVE-FVKELQDIEVPESYSGELECIVSPENIEG-----KWYHND 2303
Query: 165 VSLVSGSRFLITSTGA---LYIKDVQNED-GLYNYRCITRHRYTGETRQSNSARLFVSDP 220
V L S ++ ITS L +KDV ED G Y++ I + T + + P
Sbjct: 2304 VELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSF-VIDGKKTTCKLKMK---------P 2353
Query: 221 ANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGR----FQKTVT 276
A IL G +K G V+L K + + W+KD ++ S R K
Sbjct: 2354 RPIA--ILQGLSDQKVCEGDIVQLEVK-VSLESVEGVWMKDGQEVQPSDRVHIVIDKQSH 2410
Query: 277 GLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRK-VKSSVGSQVSLSC 335
LLIE++ D+G+Y + GR+ V I+P K V G++ L C
Sbjct: 2411 MLLIEDMTKEDAGNYSFTIPAL--GLSTSGRVSVYSV--DVITPLKDVNVIEGTKAVLEC 2466
Query: 336 SVTGTEDQELSWYRNGEILNPGKNVR-ITGINHENLIMDHMVKSDGGAYQCFVRKDKLSA 394
V+ + + WY N E + P V+ I + L+++ SD G Y+ V + + +
Sbjct: 2467 KVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLIVGRVETNC 2526
Query: 395 QDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHR 454
V+ + KII + + + V + + + + W D I ++
Sbjct: 2527 NLSVEKI------KIIRGLRDLTCTETQNVVFEVELSHSGIDVL-WNFKDKEIKPSSKYK 2579
Query: 455 ISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNIT 514
I + G + L + + D G Y A + + ++ V G A +P+ + T
Sbjct: 2580 IE----AHGKIYK-LTVLNMMKDDEGKYTFYAGEN----MTSGKLTVAGGAISKPLTDQT 2630
Query: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLK--LSDVQKEVDEGE 572
++ C V P +W ++ LP + + E++G + + K D GE
Sbjct: 2631 VAESQEAVFECEVAN-PDSKGEWLRDGKHLPLTN-NIRSESDGHKRRLIIAATKLDDIGE 2688
Query: 573 YTCNVLVQPQLSTSQSVHV-TVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQ 631
YT V TS + V VK+ ++ VF V ++ + W
Sbjct: 2689 YTYKVATS---KTSAKLKVEAVKIKKTLKNLTVTETQ--DAVF--TVELTHPNVKGVQWI 2741
Query: 632 KDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTC-IARNEAAAVEHQSQLIVRVPP 690
K+G + + I SLRI N +++ Y + R A+A H +
Sbjct: 2742 KNGVVLESNEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVETV------ 2795
Query: 691 KFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGS 750
K + +P+D + V S VP + W F K + +P + +
Sbjct: 2796 KIIKKPKDVTALENATVAFEVSVSHDTVP-VKW-FHKSV---EIKPSDKHRLVSERKVHK 2850
Query: 751 LLIKHVVEEDSGYYLCKVSNDVGADVSKSMYL-TVKIPAMITSYPNTTLATQGQKKEMSC 809
L+++++ D+G Y V + +++ T+ I + + T + E+S
Sbjct: 2851 LMLQNISPSDAGEYTAVVGQ---LECKAKLFVETLHITKTMKNIEVPETKTASFECEVS- 2906
Query: 810 TAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSG--FFSCHA 867
H P + W K + EM+ K V + + L I+ T EDS F C
Sbjct: 2907 --HFNVPSM--WLKNG--VEIEMSE---KFKIVVQGKLHQLIIMNTSTEDSAEYTFVC-- 2955
Query: 868 INSYGEDRGIIQLTVQEPPDPPEIEIKDVKAR---TITLRWTMGFDGNS---PITGYDIE 921
G D+ LTV P +KD+ A TIT T+ ++G S G +I+
Sbjct: 2956 ----GNDQVSATLTV--TPIMITSMLKDINAEEKDTITFEVTVNYEGISYKWLKNGVEIK 3009
Query: 922 CKNKSDSWDSAQRTKDVSPQLN 943
+K RTK ++ LN
Sbjct: 3010 STDKCQ-----MRTKKLTHSLN 3026
Score = 73.2 bits (178), Expect = 2e-12
Identities = 122/605 (20%), Positives = 220/605 (36%), Gaps = 67/605 (11%)
Query: 704 GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQV---LSNGSLLIKHVVEED 760
G + L G P P + W K A + + R+++ + + D
Sbjct: 18216 GDTIRLEAGVRGKPFPEVAWTKDKDA-----TDLTRSPRVKIDTRADSSKFSLTKAKRSD 18270
Query: 761 SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR 820
G Y+ +N G+ V+ Y TV + L G + + V
Sbjct: 18271 GGKYVVTATNTAGSFVA---YATVNV-----------LDKPGPVRNLKIVDVSSDRCTVC 18316
Query: 821 WEKEDRIINPEMARYLVSTKEVGEEVISTLQ---------ILPTVREDSGFFSCHAINSY 871
W+ + E+ Y++ E V ST + + + F A N
Sbjct: 18317 WDPPEDDGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKI 18376
Query: 872 G-----EDRGIIQLTVQEPP---DPPEIEIKDVKARTITLRWTMG-FDGNSPITGYDIEC 922
G E + +I T + P DPPE+ V +T+ W +DG ITGY +E
Sbjct: 18377 GTGPPTESKPVIAKTKYDKPGRPDPPEVT--KVSKEEMTVVWNPPEYDGGKSITGYFLEK 18434
Query: 923 KNK-SDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS--NELTITA 979
K K S W ++ ++ ++ P Y R+ A+N IG EPS + +
Sbjct: 18435 KEKHSTRWVPVNKSAIPERRMKVQNLL---PDHEYQFRVKAENEIGIGEPSLPSRPVVAK 18491
Query: 980 DEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIIS 1039
D P GPP + + SI + W P II GY + R +
Sbjct: 18492 DPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAPII-GYVVEMRPKIADASPDEGWKR 18550
Query: 1040 VDTSGD--SEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQA 1097
+ + + +T+ +L++ +Y V A N+ G G ++ + ++ P +
Sbjct: 18551 CNAAAQLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAE--LKEAIKPKEILEPPEIDL 18608
Query: 1098 IATSPESISISWSTLSKEALNGILQGFRV--IYWANL-MDGEL--GEIKNITTTQPSLEL 1152
A+ + + + + L I++G + W + +D + G++ ++ T L +
Sbjct: 18609 DASMRKLVIVRAGCPIR--LFAIVRGRPAPKVTWRKVGIDNVVRKGQV-DLVDTMAFLVI 18665
Query: 1153 DGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKE-DVPGPPAGVKAAAASASMVFVSWLP 1211
+ + + AG+ + +F + D PGP + +K + + + VSW P
Sbjct: 18666 PNSTRDDSGKYSLTLVNPAGE----KAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAP 18721
Query: 1212 PLKLNGI-IRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRG 1270
P G + Y V S S+ + NL +Y V AV G G
Sbjct: 18722 PENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPG 18781
Query: 1271 NSSEI 1275
+++
Sbjct: 18782 VPTDV 18786
Score = 72.0 bits (175), Expect = 5e-12
Identities = 161/791 (20%), Positives = 293/791 (37%), Gaps = 100/791 (12%)
Query: 130 VEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTG---ALYIKDV 186
+ D K + A F+C + + + W K T + RF + G ++ IK
Sbjct: 11846 LSDVKVFEKDEAKFECEVSREPKTF----RWLKGTQEITGDDRFELIKDGTKHSMVIKSA 11901
Query: 187 QNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPC 246
ED ++ + E + ++ + + D K A VEL
Sbjct: 11902 AFEDE-------AKYMFEAEDKHTSGKLIIEGIRLKFLTPLKDVTAKEKESAVFTVEL-- 11952
Query: 247 KALGHPEPDYRWLKDNMPLE----LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTA 302
H +W K++ L +S + + + +++ D+ E A
Sbjct: 11953 ---SHDNIRVKWFKNDQRLHTTRSVSMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEA 12009
Query: 303 KVI---GRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN 359
K+ G Y L+ K +V L C ++ D + W+++G+ + P KN
Sbjct: 12010 KLTVLEGDPYFTGKLQDYTGVEK------DEVILQCEISKA-DAPVKWFKDGKEIKPSKN 12062
Query: 360 VRITGINHEN-LIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVV 418
I + LI+ +KSD G Y C DK S ++ +ED K++ V
Sbjct: 12063 AVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSG----KLDIEDREIKLVRPLHSVEV 12118
Query: 419 SPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRD 478
E + + W L + +L+ I + EG + S + + +
Sbjct: 12119 METETARFETEISEDDIHA-NWKLKGEALLQTPDCEIKE----EGKIHSLVLHNCRLDQT 12173
Query: 479 GGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWY 538
GGV AN + L R+ R +RP+K++T AG C + Y ++WY
Sbjct: 12174 GGVDFQAANVKSSAHL---RVKPRVIGLLRPLKDVTVTAGETATFDCE-LSYEDIPVEWY 12229
Query: 539 -KNSNLLPFNHRQVAFENNG---TLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVK 594
K L P + +V + G TL L DV+ E D GE L T ++ V
Sbjct: 12230 LKGKKLEPSD--KVVPRSEGKVHTLTLRDVKLE-DAGEVQ---LTAKDFKTHANLFVKEP 12283
Query: 595 VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSL 654
F +P E G + C V + + W K+G I S I L
Sbjct: 12284 PVEFTKPLEDQTVEEGATAVLECEVSREN--AKVKWFKNGTEILKSKKYEIVADGRVRKL 12341
Query: 655 RISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFV--------VQPRDQDGIYGKA 706
I + + YTC A+ + ++ + V P V +Q R+++ +
Sbjct: 12342 VIHDCTPEDIKTYTCDAK------DFKTSCNLNVVPPHVEFLRPLTDLQVREKEMARFEC 12395
Query: 707 VILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGS---LLIKHVVEEDSGY 763
+ +A+ + W F GA + + + ++S G+ L+I + +D
Sbjct: 12396 ELSRENAK------VKW-FKDGAEIKK------GKKYDIISKGAVRILVINKCLLDDEAE 12442
Query: 764 YLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK 823
Y C +V + M ++ A+ T ++ ++ C ++ ++
Sbjct: 12443 YSC----EVRTARTSGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKG 12498
Query: 824 EDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDR-GIIQLTV 882
++ II E RY + T+ G + I +Q ED+G ++C +S + + + +L
Sbjct: 12499 DEEII--ETGRYEILTE--GRKRILVIQ--NAHLEDAGNYNCRLPSSRTDGKVKVHELAA 12552
Query: 883 QEPPDPPEIEI 893
+ P +EI
Sbjct: 12553 EFISKPQNLEI 12563
Score = 70.1 bits (170), Expect = 2e-11
Identities = 106/497 (21%), Positives = 187/497 (37%), Gaps = 71/497 (14%)
Query: 819 VRWEKEDRIINPEMARYLVSTKEV---GEEVISTL------QILPTVREDSGFFSCHAIN 869
++W ++ + Y+V ++V G + + T + P F A N
Sbjct: 14102 LKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYVFRVAAEN 14161
Query: 870 SYG-------EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGF-DGNSPITGYDIE 921
+ G ED + + T P P + + DV R + L+W DG PI Y IE
Sbjct: 14162 AIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIE 14221
Query: 922 CKNKSDS-WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN--ELTIT 978
K + + W A +T P N + D+ + ++ A+N G PS E+
Sbjct: 14222 KKERLGTRWVKAGKT--AGPDCNFR-VTDVIEGTEVQFQVRAENEAGVGHPSEPTEILSI 14278
Query: 979 ADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNII 1038
D +P PP ++H+ + I + WK P+K+ + II GY + E G ++ +
Sbjct: 14279 EDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPII-GYHV---EMCPVGTEKWMRV 14334
Query: 1039 SVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PS--SQEIITTTLEDVPSYPPENV 1095
+ D + + + +Y L V+A N G PS S+ ++ + P+ E
Sbjct: 14335 NSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETH 14394
Query: 1096 QAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGL 1155
I E +SI FR + + ++ + E+
Sbjct: 14395 DIIVIEGEKLSIP-------------VPFRAV-----------PVPTVSWHKDGKEVKAS 14430
Query: 1156 EKYTNYSIQVLAFTRAGDGVRSEQ-IFTRTKED---------------VPGPPAGVKAAA 1199
++ T + + A VR++ I+T T E+ +PGP +KA+
Sbjct: 14431 DRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASD 14490
Query: 1200 ASASMVFVSWLPPLKLNGI-IRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYS 1258
+ S ++W PP G I Y + + + S+ + +L N +Y
Sbjct: 14491 ITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYF 14550
Query: 1259 VWVVAVTSAGRGNSSEI 1275
V AV G G E+
Sbjct: 14551 FRVKAVNKVGGGEYIEL 14567
Score = 70.1 bits (170), Expect = 2e-11
Identities = 78/364 (21%), Positives = 148/364 (40%), Gaps = 25/364 (6%)
Query: 156 TVVSWEKDTVSLVSGSRFLITSTGA---LYIKDVQNED-GLYNYRCITRHRYTGETRQSN 211
T V W + V L + + +G+ L IK + D G+ CI++ T E
Sbjct: 33066 TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILT--CISK---TKEGIVKC 33120
Query: 212 SARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRF 271
L +S + AP+ + + GQ V C+ G P P+ W K+N+P+ +S
Sbjct: 33121 QYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNV 33180
Query: 272 ----QKTVTGLLIENIRPSDSGSYVCEVSNRYG----TAKVIGRLYVKQPLKATISPRKV 323
+ V L I N SDSG Y + N G TA ++ V++P + +
Sbjct: 33181 SISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSG 33240
Query: 324 KSSV-GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENL--IMDHMVKSDG 380
+S+ GS S S ++ ++ + + + ++ ++ +++ + + V+
Sbjct: 33241 DTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSS 33300
Query: 381 GAYQCFVRKDKL--SAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTI 438
++ +L S ++ + PKI + S+ + + +++ C G P P +
Sbjct: 33301 SSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEV 33360
Query: 439 TWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQAR 498
TW+ I R T + ++ L I Q +DGG+Y + N G
Sbjct: 33361 TWSCGGRKIHSQEQGRFHIENTDD---LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVN 33417
Query: 499 INVR 502
I++R
Sbjct: 33418 IHIR 33421
Score = 68.9 bits (167), Expect = 5e-11
Identities = 150/695 (21%), Positives = 246/695 (35%), Gaps = 160/695 (23%)
Query: 234 RKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV---TG---LLIENIRPSD 287
+K + G V C+ G+P+P W K +PL R++ + TG L+I D
Sbjct: 1091 QKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADD 1150
Query: 288 SGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSW 347
+G Y V N++G + S S S+ D EL
Sbjct: 1151 AGEYTIVVRNKHG-----------------------------ETSASASLLEEADYELLM 1181
Query: 348 YRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAY----------QCFVRKDKLSAQDY 397
E+L ++T E + + + G Y Q +RK
Sbjct: 1182 KSQQEMLY---QTQVTAFVQEPKVGE---TAPGFVYSEYEKEYEKEQALIRKKMAKDTVV 1235
Query: 398 VQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQ 457
V+ +ED I S+F E+++ E I TL++
Sbjct: 1236 VRTYVEDQEFHI-SSFEERLIKEIE------------YRIIKTTLEE------------- 1269
Query: 458 MITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIA 517
++ +G ++IS S+ + G + +RI KN +
Sbjct: 1270 LLEEDGEEKMAVDISESEAVESG--------------FDSRI-----------KNYRILE 1304
Query: 518 GRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR-QVAFENNG--TLKLSDVQKEVDEGEYT 574
G HC++ GYP I WYK+ + R Q+ F +G +L++ V E DEG YT
Sbjct: 1305 GMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPE-DEGIYT 1363
Query: 575 CNVL-VQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKD 633
++ S ++V P +G +IP + P++
Sbjct: 1364 AFASNIKGNAICSGKLYVEPAAP------------LGAPTYIPTLE-----PVSRIRSLS 1406
Query: 634 GRPIPGSLGVTIDNIDFTSSLRISNLSL----MHNGNYTCIARNEAAAVEH--QSQLIVR 687
R + S +R+S + M + + +E +SQL
Sbjct: 1407 PRSVS------------RSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERL 1454
Query: 688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLS 747
P FV++P + G+ + G P+P W F G + ++ +
Sbjct: 1455 YKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFW-FHDGQQIVN----DYTHKVVIKE 1509
Query: 748 NG--SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKI------PAMITSYPNTTLA 799
+G SL+I DSG + N G S S+ LTV+ P + N +
Sbjct: 1510 DGTQSLIIVPATPSDSGEWTVVAQNRAGRS-SISVILTVEAVEHQVKPMFVEKLKNVNIK 1568
Query: 800 TQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED 859
+G + EM A G + W K II P + GE + L+I TV +D
Sbjct: 1569 -EGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGE---AALKIDSTVSQD 1624
Query: 860 SGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIK 894
S +++ AIN G D ++ V+ PE E K
Sbjct: 1625 SAWYTATAINKAGRDTTRCKVNVEVEFAEPEPERK 1659
Score = 68.9 bits (167), Expect = 5e-11
Identities = 147/685 (21%), Positives = 260/685 (37%), Gaps = 118/685 (17%)
Query: 159 SWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVS 218
+W+K + +F I G L E Y +R + TG +R +A +
Sbjct: 30476 AWKKSNKERIKDKQFTI---GGLL------EATEYEFRVFAENE-TGLSRPRRTAMSIKT 30525
Query: 219 D-PANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG 277
+ AP I G+ +L C+ +G P PD +W + L S +++ + G
Sbjct: 30526 KLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDG 30585
Query: 278 ----LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVK--------QPLKATISPRKVKS 325
L + D G Y C +N G + +L ++ PLK K
Sbjct: 30586 RTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLK-----EKYYG 30640
Query: 326 SVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINH-ENLIMDHMV-KSDGGAY 383
+VGS + L G ++W+ ++L +N+ I H +L+M ++ K+ G Y
Sbjct: 30641 AVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKY 30700
Query: 384 QCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLD 443
+ + + + V ++D K P P+ + +K + + I+W
Sbjct: 30701 KVQLSNVFGTVDAILDVEIQDKPDK-----------PTGPIVIEALLKNSAV--ISW--- 30744
Query: 444 DDPILKGGS----HRISQMITSEGN----VVSYLNISSSQV-----RDGGVYRCTANNSA 490
P GGS + + + EG V S +++++ ++ G +R +A N+
Sbjct: 30745 KPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTF 30804
Query: 491 GV---VLYQARINVRGP-----ASIRPMKNITAIAGRDTYIHCRVIGYP----------- 531
G+ + + + ++ P A +P ITA+ T C V P
Sbjct: 30805 GISDPLEVSSVVIIKSPFEKPGAPGKP--TITAV----TKDSCVVAWKPPASDGGAKIRN 30858
Query: 532 YYSIKWYKNSN----LLPFNHRQVAFENNGTLKLSDVQKEVD----EGEYTCNVLVQPQL 583
YY K K N + R+ F ++ + + V GE + + +P
Sbjct: 30859 YYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPIT 30918
Query: 584 STSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGV 643
S V ++ P F + + C V PI + W + G+ I G+
Sbjct: 30919 PKSD---VPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPI-VKWYRQGKEIIAD-GL 30973
Query: 644 TIDNIDFTS---SLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQD 700
+F L I++++ Y A N+ +V + L V VP K + P+ +
Sbjct: 30974 KYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAK-IHLPKTLE 31032
Query: 701 G------IYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVL---SNGSL 751
G + G+ V + G P P I W+ KG + I NG QV+ S SL
Sbjct: 31033 GMGAVHALRGEVVSIKIPFSGKPDPVITWQ--KGQDL-----IDNNGHYQVIVTRSFTSL 31085
Query: 752 LIKHVVE-EDSGYYLCKVSNDVGAD 775
+ + VE +D+G+Y+ N G D
Sbjct: 31086 VFPNGVERKDAGFYVVCAKNRFGID 31110
Score = 67.0 bits (162), Expect = 2e-10
Identities = 76/314 (24%), Positives = 124/314 (39%), Gaps = 49/314 (15%)
Query: 233 HRKAMAGQRVELPCKALGHPEP-DYRWLKDNMPLELSGRFQKT----VTGLLIENIRPSD 287
H G V+ CK + + W LE S +++ T V L +++I D
Sbjct: 31576 HAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLD 31635
Query: 288 SGSYVCEVSNRYGTAKVIGRLYVK----------------------------QPLKATIS 319
G+Y C+V N YG L+VK +P + T+
Sbjct: 31636 DGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLP 31695
Query: 320 PRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN-VRITGINHENL--IMDHMV 376
+ VG V ++T + ++WY++G+ + PG N + T + + L + + V
Sbjct: 31696 LYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSV 31755
Query: 377 KSDGGAYQCFVRKDKL---SAQDYVQVVLE-DGTPKIISAFSEKVVSPAE-----PVSLM 427
+D A V ++K S + + V L T + +++++ AE V
Sbjct: 31756 TTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFE 31815
Query: 428 CNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTAN 487
V G P PT+ W D P+ G + I EG L+I + D G YR TA
Sbjct: 31816 IRVSGIPPPTLKWEKDGQPLSLGPNIE----IIHEGLDYYALHIRDTLPEDTGYYRVTAT 31871
Query: 488 NSAGVVLYQARINV 501
N+AG QA + V
Sbjct: 31872 NTAGSTSCQAHLQV 31885
Score = 66.6 bits (161), Expect = 2e-10
Identities = 108/472 (22%), Positives = 174/472 (36%), Gaps = 91/472 (19%)
Query: 162 KDTV---SLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVS 218
KDTV + V F I+S IK+++ YR I + T E ++
Sbjct: 1231 KDTVVVRTYVEDQEFHISSFEERLIKEIE-------YRII---KTTLEELLEEDGEEKMA 1280
Query: 219 DPANSAPSILDGFDHR----KAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKT 274
+ + ++ GFD R + + G V CK G+P P W KD ++ R+Q
Sbjct: 1281 VDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMD 1340
Query: 275 V-----TGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVK--QPLKA----------- 316
L I + P D G Y SN G A G+LYV+ PL A
Sbjct: 1341 FLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVS 1400
Query: 317 ---TISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMD 373
++SPR V S S +S R ++PG+ + T + +
Sbjct: 1401 RIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPAR----MSPGRRLEETDESQLERLYK 1456
Query: 374 HMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGT 433
+ +++C LE T + F KVV G
Sbjct: 1457 PVFVLKPVSFKC----------------LEGQTAR----FDLKVV-------------GR 1483
Query: 434 PLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG-- 491
P+P W D I+ +H++ +I +G L I + D G + A N AG
Sbjct: 1484 PMPETFWFHDGQQIVNDYTHKV--VIKEDG--TQSLIIVPATPSDSGEWTVVAQNRAGRS 1539
Query: 492 ----VVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL-PF 546
++ +A + P + +KN+ G + R G P I W KNS+++ P
Sbjct: 1540 SISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPH 1599
Query: 547 NHRQVAFE---NNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQ-SVHVTVK 594
+ ++ E LK+ + D YT + + T++ V+V V+
Sbjct: 1600 KYPKIRIEGTKGEAALKIDSTVSQ-DSAWYTATAINKAGRDTTRCKVNVEVE 1650
Score = 62.8 bits (151), Expect = 3e-09
Identities = 153/758 (20%), Positives = 270/758 (35%), Gaps = 86/758 (11%)
Query: 863 FSCHAINSYGEDRGII---QLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYD 919
F AINS G + QE +PPEIE+ + + LR + I G
Sbjct: 25076 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGR- 25134
Query: 920 IECKNKSDSWDSAQRTKDVSPQL---NSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELT 976
W+ A+ Q+ +S T++ I + + Y + S T
Sbjct: 25135 ---PEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRY---NLTLENNSGSKT 25188
Query: 977 ITADEAAPDGP--PQEVHLEPISSQSIRVTWKAP----KKHLQNGIIRGYQIGYREYSTG 1030
+ D P P + + + S+ ++W+ P + N I+ + + Y+T
Sbjct: 25189 AFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYAT- 25247
Query: 1031 GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSY 1090
+ + + ++NL + Y V A N G G ++ + + P
Sbjct: 25248 ---------ITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE-PPL 25297
Query: 1091 PPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSL 1150
PP V + + + +I W + G ++ + M + E + T +L
Sbjct: 25298 PPGRVTLVDVTRNTATIKWEKPESDG------GSKITGYVVEMQTKGSEKWSTCTQVKTL 25351
Query: 1151 E--LDGLEKYTNYSIQVLAFTRAGDG--------VRSEQIFTRTKEDVPGPPAGVKAAAA 1200
E + GL Y +V A G V + I + ++P VKA
Sbjct: 25352 EATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQ 25411
Query: 1201 SASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVW 1260
V P +N T+ T +S S I S+ +
Sbjct: 25412 LKIDVPFKGRPQATVNWRKDGQTL-----KETTRVNVSSSKTVTSLSIKEASKEDVGTYE 25466
Query: 1261 VVAVTSAGRGNSSEIITV--EPLAKAPARILTFS-GTVTTPWMKDIVLPCKAVGDPSPAV 1317
+ SAG I V P P RI S ++T W P + G
Sbjct: 25467 LCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWN-----PPEYDGG-CQIS 25520
Query: 1318 KWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG------SDEII 1371
++ + T S +++ I+R + + C A N +G S ++
Sbjct: 25521 NYIVEKKETTSTTWHIVSQAVARTSIKIVRLTTGSEYQFRVC-AENRYGKSSYSESSAVV 25579
Query: 1372 LNLQVQVPPDQPRLTVSKTTSSSITLSW-LPGDNGGSSIRGYILQYSEDNSEQWG-SFPI 1429
P V T S++ ++W +P ++GGS + GY L+Y E +S W + I
Sbjct: 25580 AEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKI 25639
Query: 1430 SPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINT 1489
++ ++ L G Y++ + A+N G G+ S+ E ++P Q +I
Sbjct: 25640 LIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCE-PVPARDPCDPPGQPEVTNITR 25698
Query: 1490 TRVRLNLIGWN----DGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYI-LYDLQEATWY 1544
V L W+ DGG IT + +E R W T++ ++Y + +L E Y
Sbjct: 25699 KSVSLK---WSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRY 25755
Query: 1545 ELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQ 1582
E ++ N+A + + ST P ++K V+
Sbjct: 25756 EFRVFARNAADSVSEPSE--------STGPIIVKDDVE 25785
Score = 62.8 bits (151), Expect = 3e-09
Identities = 201/1014 (19%), Positives = 364/1014 (35%), Gaps = 134/1014 (13%)
Query: 618 VVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAA 677
V +SG +TW+ + + + V+I ++L + + +G Y N A
Sbjct: 28669 VPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGV 28728
Query: 678 VEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKF---SKGAGVPQF 734
++V P V P + + ++ +L+ T + + + +G +
Sbjct: 28729 KTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAW 28788
Query: 735 QPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYP 794
Q + + + + + H+ + Y +VS++ VSK + + +I +P
Sbjct: 28789 QLVNSS-----VKRTQIKVTHLTKYME--YSFRVSSENRFGVSKPL----ESAPIIAEHP 28837
Query: 795 NTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKE------VGEEVIS 848
+ + + +A+ + +RWE+ ++ Y V KE V E +
Sbjct: 28838 FVPPSAPTRPEVYHVSANA---MSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVP 28894
Query: 849 TLQ----ILPTVREDSGFFSCHAINSYGEDRGIIQ---LTVQEPPDPP-EIEIKDVKART 900
L+ + V F +A+N+ G + + Q P D P E+ DV T
Sbjct: 28895 CLECNYKVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRST 28954
Query: 901 ITLRWTM-GFDGNSPITGYDIECKNKSDSWDSAQ-RTKDVSPQLNSATIIDIHPSSTYSI 958
++L W+ +DG S + GY IE K S+ D + N T+ + TY
Sbjct: 28955 VSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEF 29014
Query: 959 RMYAKNRIGKSEPSNELT---ITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNG 1015
R+ AKN G +E T DE AP + L H
Sbjct: 29015 RVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARL-----------------HGDLV 29057
Query: 1016 IIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLN-KFT--QYGLVVQACNRAGT 1072
IR + + GG + II T GD E+ + ++ ++T + V++ C+R+ +
Sbjct: 29058 TIRAGSDLVLDAAVGGKPEPKIIW--TKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDS 29115
Query: 1073 G--------PSSQEIITTTLEDVPSYPPENVQAIA-TSPESISISWSTLSKEALNGILQG 1123
G S + ++ ++ + S P ++ + E +++WS L +E +
Sbjct: 29116 GKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWS-LPQEDGGAEITH 29174
Query: 1124 FRV-------IYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDG-- 1174
+ V + W +++GE + + T L K Y +V A + G G
Sbjct: 29175 YIVERRETSRLNWV-IVEGECPTLSYVVTR--------LIKNNEYIFRVRAVNKYGPGVP 29225
Query: 1175 VRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNG-IIRKYTVFCSHPYPTV 1233
V SE I R +P PP + + + W P G I Y V
Sbjct: 29226 VESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLV--DKREKKS 29283
Query: 1234 ISEFEASPDSFSY----RIPNLSRNRQYSVWVVAVTSAGRGNSSE----IITVEPL---- 1281
+ + D Y ++ +L Y V AV +AG SE I EP
Sbjct: 29284 LRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPG 29343
Query: 1282 -AKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFS 1340
AP + T +++ W K P G T + +I
Sbjct: 29344 PPSAPRVVDTTKHSISLAWTK----PMYDGGTDIVGYVLEMQEKDTDQWYRVHTNATI-R 29398
Query: 1341 NGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQ---PRLTVSKTTSSSITL 1397
N F + +K + A N G E ++ P ++ P L ++ ++T+
Sbjct: 29399 NTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTI 29458
Query: 1398 SWLPGDNGGSSIR---------GYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWY- 1447
G+S+R ++ +S+ + S I + SY L + Y
Sbjct: 29459 ------RAGASLRLMVSVSGRPPPVITWSKQGID-LASRAIIDTTESYSLLIVDKVNRYD 29511
Query: 1448 --KFTLTAQNGVGPGRISEIIEA-KTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGC 1504
K+T+ A+N G + +++ T G P ++ S+ T I DGG
Sbjct: 29512 AGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWE----IPTIDGGA 29567
Query: 1505 PITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAE 1558
P+ ++ +E R + T Y + L E T Y ++ N G E
Sbjct: 29568 PVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGE 29621
Score = 59.3 bits (142), Expect = 4e-08
Identities = 46/196 (23%), Positives = 79/196 (40%), Gaps = 12/196 (6%)
Query: 328 GSQVSLSCSVTGTEDQELSWYRNGEILN----PGKNVRITGINHENLIMDHMVKSDGGAY 383
GS + ++G E+SW+R+G++++ PG + + L + + K++ G Y
Sbjct: 20 GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD-GRAKLTIPAVTKANSGRY 78
Query: 384 QCFVRKDKLSAQDYVQVVL--EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWT 441
A ++++ E P + V V L V G P P + +
Sbjct: 79 SLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFY 138
Query: 442 LDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV 501
D I +ISQ EG++ S L I+ + D G Y A NS G A + V
Sbjct: 139 RDGAEIQSSLDFQISQ----EGDLYSLL-IAEAYPEDSGTYSVNATNSVGRATSTAELLV 193
Query: 502 RGPASIRPMKNITAIA 517
+G + K T ++
Sbjct: 194 QGEEEVPAKKTKTIVS 209
Score = 57.0 bits (136), Expect = 2e-07
Identities = 55/225 (24%), Positives = 103/225 (45%), Gaps = 12/225 (5%)
Query: 1375 QVQVPPDQPRLTVSKTTSSSITLSWL-PGDNGGSSIRGYILQYSEDNSEQWGSFPISP-S 1432
+V PP P +T+S + S+ + W P +GGS + GY L+ E NS W +P
Sbjct: 22339 KVPGPPGTPVVTLS--SRDSMEVQWNEPISDGGSRVIGYHLERKERNSILWVKLNKTPIP 22396
Query: 1433 ERSYRLENLKCGTWYKFTLTAQNGVG---PGRISEIIEAKTLGKEPQFSKEQELFASINT 1489
+ ++ L+ G Y+F ++A+N VG P ++SE A+ P + + + + N+
Sbjct: 22397 QTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPP--GRPEAIIVTRNS 22454
Query: 1490 TRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYI-LYDLQEATWYELQM 1548
++ + DGG IT + +E + W A T++ ++ + L E YE ++
Sbjct: 22455 VTLQWKKPTY-DGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRV 22513
Query: 1549 RVCNSAGC-AEKQANFATLNYDGSTIPPLIKSVVQNEEGLTTNEG 1592
N+AG +E + + PP I + ++ + + G
Sbjct: 22514 IARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAG 22558
Score = 56.6 bits (135), Expect = 2e-07
Identities = 74/354 (20%), Positives = 141/354 (39%), Gaps = 65/354 (18%)
Query: 471 ISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGY 530
+S++++ GG R S V A I + GP S + M + G Y+ C++ Y
Sbjct: 31538 VSAARISCGGAIRSQKGVSVAKVKV-ASIEI-GPVSGQIMHAVGEEGGHVKYV-CKIENY 31594
Query: 531 PYYS-IKWYKNSNLLPFNHR-QVAFENN-GTLKLSDVQKEVDEGEYTCNVL--------- 578
+ + WY L + + ++ +E+ L + D+ K +D+G Y C V+
Sbjct: 31595 DQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITK-LDDGTYRCKVVNDYGEDSSY 31653
Query: 579 -------------------VQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVV 619
++ + ++ + + P F P +G+ V +
Sbjct: 31654 AELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTI 31713
Query: 620 VSGDLPITITWQKDGRPI-PGSLG--VTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAA 676
P +TW K G+ I PG T ++ L I++++ + YT +ARN+
Sbjct: 31714 TVHPEP-HVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYG 31772
Query: 677 AVEHQSQLIVRVPP------------KFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWK 724
+++L V + P + + Q+G ++V G P PT+ W+
Sbjct: 31773 EDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEG---QSVCFEIRVSGIPPPTLKWE 31829
Query: 725 FSKGAGVPQFQPIALNGRIQVLSNG----SLLIKHVVEEDSGYYLCKVSNDVGA 774
QP++L I+++ G +L I+ + ED+GYY +N G+
Sbjct: 31830 -------KDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGS 31876
Score = 55.1 bits (131), Expect = 7e-07
Identities = 132/676 (19%), Positives = 243/676 (35%), Gaps = 85/676 (12%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIH-----DNTY 100
C G P+ + W R + G QI S+ T++ Y
Sbjct: 8174 CHVTGTQPIKVSW----------AKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQY 8223
Query: 101 YCTAENPSGKIR-SQDVHIKAVLREP-YTVRV-EDQKTMRGNVAVFKCIIPSSVEAYITV 157
C A N GK + ++IK L P +T R+ E + GN + + S
Sbjct: 8224 TCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPI---T 8280
Query: 158 VSWEKDTVSLVSGSRFLITSTGALYIKDVQ----NEDGLYNYRCITRHRYTGETRQSNSA 213
V+W K+ + + S IT + V+ N+ GLY T + +
Sbjct: 8281 VAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLY----------TCKVSNDAGS 8330
Query: 214 RLFVSDPANSAPSILDGFDHR----KAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSG 269
L S P FD G+ V+L C G +WLK ++ S
Sbjct: 8331 ALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSD 8390
Query: 270 R----FQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKS 325
R F L + ++ +DSG YVC+ SN G+ ++ +K K ++P K+
Sbjct: 8391 RCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKD--KPAVAPATKKA 8448
Query: 326 SVGSQV-----------------SLSCSVTGTEDQELSWYRNG-EILNPGKNVRITGINH 367
+V ++ + V G + W + LN G V I
Sbjct: 8449 AVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGD 8508
Query: 368 E-NLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSL 426
E L + K+D G Y+C + + V + +++ + + + P+
Sbjct: 8509 EAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILK 8568
Query: 427 MCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGG------ 480
+ + + + DP R+ + G + ++ + SQ +
Sbjct: 8569 KGAGEEEEIDIMELLKNVDPKEYEKYARMYGITDFRGLLQAFELLKQSQEEETHRLEIEE 8628
Query: 481 VYRCTANNSAG---VVLYQARINVRGPAS-IRPMKNITAIAGRDTYIHCRV-IGYPYYSI 535
+ R + V Q R++ P + I+ ++N T + D + I YP +
Sbjct: 8629 IERSERDEKEFEELVSFIQQRLSQTEPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKL 8688
Query: 536 KWYKNSNLL-PFNHRQVAFE-NNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTV 593
WYK + L P + +++ + + TL++ + Q + D+G Y ++ P ++ S +TV
Sbjct: 8689 SWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLK-DQGNY--RLVCGPHIA---SAKLTV 8742
Query: 594 KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSS 653
P + + + GQ + C + + W ++GR + +
Sbjct: 8743 IEPAWERHLQDVTLKEGQTCTMTCQFSVPN--VKSEWFRNGRILKPQGRHKTEVEHKVHK 8800
Query: 654 LRISNLSLMHNGNYTC 669
L I+++ G YTC
Sbjct: 8801 LTIADVRAEDQGQYTC 8816
Score = 54.3 bits (129), Expect = 1e-06
Identities = 50/197 (25%), Positives = 81/197 (41%), Gaps = 10/197 (5%)
Query: 591 VTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSL--GVTIDNI 648
+T + P F QP + G + +P ++W +DG+ I S GV I
Sbjct: 1 MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVP-EVSWFRDGQVISTSTLPGVQISFS 59
Query: 649 DFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRV---PPKFVVQPRDQDGIYGK 705
D + L I ++ ++G Y+ A N + ++L+V+ PP FV + + G
Sbjct: 60 DGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGS 119
Query: 706 AVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYL 765
V L G P P + + + GA + ++ + S LLI EDSG Y
Sbjct: 120 QVRLQVRVTGIPTPVVKF-YRDGAEIQSSLDFQISQEGDLYS---LLIAEAYPEDSGTYS 175
Query: 766 CKVSNDVGADVSKSMYL 782
+N VG S + L
Sbjct: 176 VNATNSVGRATSTAELL 192
Score = 53.9 bits (128), Expect = 2e-06
Identities = 85/367 (23%), Positives = 138/367 (37%), Gaps = 82/367 (22%)
Query: 499 INVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFN-HRQVAFENN- 556
I V P + +KN+T I G + C + GYP ++ WY+ + + Q+ F++
Sbjct: 938 IPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGI 997
Query: 557 GTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFE------FPRFSIG 610
L + + E D G +TC+ V + S S ++ V+V + FE +F+
Sbjct: 998 ARLMIREAFAE-DSGRFTCSA-VNEAGTVSTSCYLAVQVS---EEFEKETTAVTEKFTTE 1052
Query: 611 QRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCI 670
++ F V S D+ +T T + + PG
Sbjct: 1053 EKRF----VESRDVVMTDTSLTEEQAGPG------------------------------- 1077
Query: 671 ARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAG 730
E AA P F+ +P Q + G +V+ C G P P + WK S G
Sbjct: 1078 ---EPAA------------PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKS---G 1119
Query: 731 VPQFQPIALNGRIQVLSNG-----SLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMYLTV 784
V P+ R +V N L+I +D+G Y V N G S S+
Sbjct: 1120 V----PLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEA 1175
Query: 785 KIPAMITSYPNTTLATQ----GQKKEMSCTAHG--EKPIIVRWEKEDRIINPEMARYLVS 838
++ S TQ Q+ ++ TA G +EKE +I +MA+ V
Sbjct: 1176 DYELLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVV 1235
Query: 839 TKEVGEE 845
+ E+
Sbjct: 1236 VRTYVED 1242
Score = 53.5 bits (127), Expect = 2e-06
Identities = 95/430 (22%), Positives = 153/430 (35%), Gaps = 44/430 (10%)
Query: 254 PDYRWLK--DNMPLELSGRFQKTVTG----LLIENIRPSDSGSYVCEVSN-RYGTAKVIG 306
P+ +W K D +P E + + + G L I+N P D Y E+ RY +G
Sbjct: 11334 PNIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLG 11393
Query: 307 RLYVK--QPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITG 364
V+ +P++ K +S +++S + G W GE+L P I
Sbjct: 11394 EREVELLKPIEDVTIYEKESASFDAEIS-EADIPG------QWKLKGELLRPSPTCEIKA 11446
Query: 365 INHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYV--QVVLEDGTPKIISAFSEKVVSPAE 422
+ + H VK D + + ++ ++ L+ P E+ + E
Sbjct: 11447 EGGKRFLTLHKVKLDQAGEVLYQALNAITTAILTVKEIELDFAVPLKDVTVPERRQARFE 11506
Query: 423 PV-SLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGV 481
V + NV + P I + D I+ G I L I+ SQ D GV
Sbjct: 11507 CVLTREANVIWSKGPDIIKSSDKFDIIADGKKHI-------------LVINDSQFDDEGV 11553
Query: 482 YRCTANNSAGVVLYQARINVRGPAS--IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK 539
Y AR+ V G + P+++ T G C + + + W+K
Sbjct: 11554 YTAEVEGKKT----SARLFVTGIRLKFMSPLEDQTVKEGETATFVCE-LSHEKMHVVWFK 11608
Query: 540 NSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFI 599
N L + + T KL KEV + + +LS++ + V P F
Sbjct: 11609 NDAKLHTSRTVLISSEGKTHKLE--MKEVTLDDISQIKAQVKELSSTAQLKVLEADPYFT 11666
Query: 600 QPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNL 659
+ + C V S D+P+ W KDG I S +I L+I
Sbjct: 11667 VKLHDKTAVEKDEITLKCEV-SKDVPVK--WFKDGEEIVPSPKYSIKADGLRRILKIKKA 11723
Query: 660 SLMHNGNYTC 669
L G Y C
Sbjct: 11724 DLKDKGEYVC 11733
Score = 51.2 bits (121), Expect = 1e-05
Identities = 74/424 (17%), Positives = 153/424 (36%), Gaps = 31/424 (7%)
Query: 220 PANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRF-----QKT 274
P+ AP I + + G + +G P+P+ W K+ + +E S R +
Sbjct: 2073 PSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDN 2132
Query: 275 VTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYV--KQPLKATISPRKVKSSVGSQVS 332
V L+I ++ DS S + + N G L V KQ + T + V + ++
Sbjct: 2133 VCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMA 2192
Query: 333 LSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMV-KSDGGAYQCFVRKDK 391
T ++ WY++G ++ G R+ + + + SD Y C + +D+
Sbjct: 2193 TFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDE 2252
Query: 392 LSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMC-----NVKGTPLPTITWTLDDDP 446
+ + ++++E + + + V + L C N++G W +D
Sbjct: 2253 -NVKTTAKLIVEGAVVEFVKELQDIEVPESYSGELECIVSPENIEG------KWYHNDVE 2305
Query: 447 ILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS 506
+ G + I+ + L + D G Y + + ++ R A
Sbjct: 2306 LKSNGKYTITSRRGRQN-----LTVKDVTKEDQGEYSFVIDGKK--TTCKLKMKPRPIAI 2358
Query: 507 IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQK 566
++ + + G + +V + + P + + + + L +
Sbjct: 2359 LQGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMT 2418
Query: 567 EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPI 626
+ D G Y+ + P L S S V+V I P + G + + C V D+
Sbjct: 2419 KEDAGNYSFTI---PALGLSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVPDV-T 2474
Query: 627 TITW 630
++ W
Sbjct: 2475 SVKW 2478
Score = 48.5 bits (114), Expect = 6e-05
Identities = 83/383 (21%), Positives = 135/383 (35%), Gaps = 74/383 (19%)
Query: 236 AMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LLIENIRPSDSGSY 291
A AG+ V++ G P P W KD L R+ T L I + +D+G Y
Sbjct: 27283 AKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKY 27342
Query: 292 VCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNG 351
+ + N G +P +T+S + + + Q L L W +
Sbjct: 27343 ILTIENGVG-----------EPKSSTVSVKVLDTPAACQ-KLQVKHVSRGTVTLLW--DP 27388
Query: 352 EILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIIS 411
+++ G + IN+ + K D V K S+ + + L + TP
Sbjct: 27389 PLIDGGSPI----INYV------IEKRDATKRTWSVVSHKCSSTSFKLIDLSEKTPFFFR 27438
Query: 412 AFSEKVVSPAEPVSLMCNVKGTPLPT----------------ITWTLDDDPILKGGSHRI 455
+E + EP VK +P ++WT P GGS
Sbjct: 27439 VLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWT---KPDFDGGSVIT 27495
Query: 456 SQMITSEG---------NVVSYLNISSSQVRDGGV--YRCTANNSAG---------VVLY 495
++ +G + I SQ+++ V +R A N G + +
Sbjct: 27496 EYVVERKGKGEQTWSHAGISKTCEIEVSQLKEQSVLEFRVFAKNEKGLSDPVTIGPITVK 27555
Query: 496 QARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQ-VAF- 553
+ I S P +T G + ++ G P SI W K+ LP + V F
Sbjct: 27556 ELIITPEVDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDG--LPLKESEFVRFS 27613
Query: 554 --ENNGTLKLSDVQKEVDEGEYT 574
EN TL + + +KE G+YT
Sbjct: 27614 KTENKITLSIKNAKKE-HGGKYT 27635
Score = 48.1 bits (113), Expect = 8e-05
Identities = 40/157 (25%), Positives = 71/157 (45%), Gaps = 12/157 (7%)
Query: 368 ENLIMDHMV--KSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVS 425
EN I + V K++GG ++ + +D + VL+ +++ V + +
Sbjct: 18167 ENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLT------VKAGDTIR 18220
Query: 426 LMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCT 485
L V+G P P + WT D D S R+ ++ S +++ ++ DGG Y T
Sbjct: 18221 LEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADS---SKFSLTKAKRSDGGKYVVT 18277
Query: 486 ANNSAGVVLYQARINVRG-PASIRPMKNITAIAGRDT 521
A N+AG + A +NV P +R +K + + R T
Sbjct: 18278 ATNTAGSFVAYATVNVLDKPGPVRNLKIVDVSSDRCT 18314
Score = 48.1 bits (113), Expect = 8e-05
Identities = 99/404 (24%), Positives = 153/404 (37%), Gaps = 66/404 (16%)
Query: 238 AGQRVELPCKALGHPEPDYRWLK---DNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCE 294
AG + L G P P W K DN+ + T+ L+I N DSG Y
Sbjct: 18620 AGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLT 18679
Query: 295 VSNRYGTAKV------------IGRLYVKQPLKAT--ISPRKVKSSVGSQVSLSCSVTGT 340
+ N G V + L V K + +S ++ GSQV+ V
Sbjct: 18680 LVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVT-HYIVEKR 18738
Query: 341 EDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQV 400
E +W + P V+ T + NL+ G Y V + +Y
Sbjct: 18739 EADRKTW----STVTP--EVKKTSFHVTNLV-------PGNEYYFRVT----AVNEYGPG 18781
Query: 401 VLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMIT 460
V D PK + A S+ + P P L T+ W P L+ G +I IT
Sbjct: 18782 VPTD-VPKPVLA-SDPLSEPDPPRKLEVTEMTKNSATLAWL----PPLRDGGAKIDGYIT 18835
Query: 461 S------------EGNVVSYLNISSSQVRDGGVY--RCTANNSAGVVL-------YQARI 499
S E +VV L++ + +++G Y R A N+ GV L Y+A+
Sbjct: 18836 SYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKE 18895
Query: 500 NVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSN-LLPFNHRQV-AFENNG 557
+ P + P + IT AG+ I V G P+ + KW K + ++ +H V +++
Sbjct: 18896 QLLPPKILMP-EQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSS 18954
Query: 558 TLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQP 601
L + DV ++ D G Y+ T + V + P QP
Sbjct: 18955 ILIIKDVTRK-DSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQP 18997
Score = 47.8 bits (112), Expect = 1e-04
Identities = 56/277 (20%), Positives = 95/277 (34%), Gaps = 18/277 (6%)
Query: 224 APSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LL 279
AP I + GQ P + +W + + L+ S + T T L
Sbjct: 32373 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLE 32432
Query: 280 IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTG 339
I + DSG+Y +N G A L V T + ++ V S+ +T
Sbjct: 32433 ILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPR--SVFPELTR 32490
Query: 340 TEDQELSWYRNGEILNPGKNVR-----ITGINHENLIMDHMVKSDGGAYQCFVRKDKLSA 394
TE +S ++ + +VR +T +H ++ + + L
Sbjct: 32491 TEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAE--MKSAALEEKSLEE 32548
Query: 395 QDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHR 454
+ + + +I++ V E C+ G P+PT+TW + H+
Sbjct: 32549 KSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQ 32608
Query: 455 ISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG 491
++ S ISS Q D G Y NS G
Sbjct: 32609 VTTT-----KYKSTFEISSVQASDEGNYSVVVENSEG 32640
Score = 47.0 bits (110), Expect = 2e-04
Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 5/87 (5%)
Query: 407 PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 466
P ++S V E V+L C++ G P PT+TW +D I I IT + +
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQI----ESSIDFQITFQSG-I 997
Query: 467 SYLNISSSQVRDGGVYRCTANNSAGVV 493
+ L I + D G + C+A N AG V
Sbjct: 998 ARLMIREAFAEDSGRFTCSAVNEAGTV 1024
Score = 47.0 bits (110), Expect = 2e-04
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 4/81 (4%)
Query: 225 PSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKT----VTGLLI 280
P+++ G + + G+ V L C G+P P W +++ +E S FQ T + L+I
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMI 1002
Query: 281 ENIRPSDSGSYVCEVSNRYGT 301
DSG + C N GT
Sbjct: 1003 REAFAEDSGRFTCSAVNEAGT 1023
Score = 46.2 bits (108), Expect = 3e-04
Identities = 30/78 (38%), Positives = 37/78 (47%), Gaps = 5/78 (6%)
Query: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI--IRTVKAEDSGYYSCIAN 1362
L CK G P V W K++ T+ R F N I I VK EDSG YSC A
Sbjct: 3757 LHCKLKGSPVIQVTWFKNNKELSESNTV---RMYFVNSEAILDITDVKVEDSGSYSCEAV 3813
Query: 1363 NNWGSDEIILNLQVQVPP 1380
N+ GSD + ++ PP
Sbjct: 3814 NDVGSDSCSTEIVIKEPP 3831
Score = 46.2 bits (108), Expect = 3e-04
Identities = 36/120 (30%), Positives = 54/120 (45%), Gaps = 23/120 (19%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRR---SIFSNG-SFIIRTVKAEDSGYYS 1358
+V+ CK G P +V W + N S GR+ ++ N + + ++ DSG Y+
Sbjct: 7699 VVMECKVYGSPPISVSWFHEGNEISS-----GRKYQTTLTDNTCALTVNMLEESDSGDYT 7753
Query: 1359 CIANNNWGSDEIILNLQVQVPPD-------QPRLTVSKTTSSSI-------TLSWLPGDN 1404
CIA N GSDE L V+ PP LT + T +SI ++SW G +
Sbjct: 7754 CIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSS 7813
Score = 46.2 bits (108), Expect = 3e-04
Identities = 64/295 (21%), Positives = 109/295 (36%), Gaps = 34/295 (11%)
Query: 218 SDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSG---RFQKT 274
SD AP + + L CK GHP+P +W + + G R Q+
Sbjct: 30921 SDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEF 30980
Query: 275 VTG---LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPR-----KVKSS 326
G L+I ++ D+ Y +N+ G+ L V+ P K + V +
Sbjct: 30981 KGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHAL 31040
Query: 327 VGSQVSLSCSVTGTEDQELSWYRNGEIL-NPGKNVRITGINHENLIMDHMV-KSDGGAYQ 384
G VS+ +G D ++W + +++ N G I + +L+ + V + D G Y
Sbjct: 31041 RGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYV 31100
Query: 385 CFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDD 444
+ Q V++ + D P P + + +TWT
Sbjct: 31101 VCAKNRFGIDQKTVELDVAD--------------VPDPPRGVKVSDVSRDSVNLTWT--- 31143
Query: 445 DPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARI 499
+P GGS +I+ I + + + Q R+ R T N G YQ R+
Sbjct: 31144 EPASDGGS-KITNYIVEKCATTAERWLRVGQARE---TRYTVINLFGKTSYQFRV 31194
Score = 46.2 bits (108), Expect = 3e-04
Identities = 60/268 (22%), Positives = 102/268 (38%), Gaps = 27/268 (10%)
Query: 100 YYCTAENPSGKIRSQDVHIKAVLREP-YTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVV 158
YYC KI+ + ++ + R P +T+ + ++ G F I E ++T
Sbjct: 31667 YYC--RRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVT-- 31722
Query: 159 SWEKDTVSLVSGS---RFLITSTGALY---IKDVQNEDGLYNYRCITRHRYTGETRQSNS 212
W K + G ++ S LY I V +D Y + R++Y ++ ++
Sbjct: 31723 -WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDA-EYTVVARNKYGEDSCKAKL 31780
Query: 213 ARLFVSDPANSA--PSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGR 270
P +S P + + GQ V + G P P +W KD PL L
Sbjct: 31781 TVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPN 31840
Query: 271 FQKTVTG-----LLIENIRPSDSGSYVCEVSNRYGTAKVIGRL------YVKQPLKATIS 319
+ G L I + P D+G Y +N G+ L Y KQ K+
Sbjct: 31841 IEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEFKSKEE 31900
Query: 320 -PRKVKSSVGSQVSLSCSVTGTEDQELS 346
R V+ + + ++ ++GTE L+
Sbjct: 31901 HERHVQKQIDKTLRMAEILSGTESVPLT 31928
Score = 45.4 bits (106), Expect = 5e-04
Identities = 57/209 (27%), Positives = 90/209 (43%), Gaps = 27/209 (12%)
Query: 498 RINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLP--FNHRQVAFEN 555
R+ R P P+ N TA G + + +P + WYK+ + N ++ FE+
Sbjct: 31684 RLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFES 31743
Query: 556 NGTLKLSDVQKEV--DEGEYTCNVLVQPQL---STSQSVHVTVKVPPF---IQPFEFPRF 607
+ L + D+ EYT V+ + + S + VT+ PP ++P F R
Sbjct: 31744 DKGLYQLTINSVTTDDDAEYT--VVARNKYGEDSCKAKLTVTLHPPPTDSTLRPM-FKRL 31800
Query: 608 SI------GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTI----DNIDFTSSLRIS 657
GQ V + VSG P T+ W+KDG+P+ SLG I + +D+ +L I
Sbjct: 31801 LANAECQEGQSVCFE-IRVSGIPPPTLKWEKDGQPL--SLGPNIEIIHEGLDY-YALHIR 31856
Query: 658 NLSLMHNGNYTCIARNEAAAVEHQSQLIV 686
+ G Y A N A + Q+ L V
Sbjct: 31857 DTLPEDTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 45.1 bits (105), Expect = 7e-04
Identities = 54/227 (23%), Positives = 95/227 (41%), Gaps = 15/227 (6%)
Query: 548 HRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVP-PFIQPFEFPR 606
HR +A + L + DVQ D GEYTC + + + TS + V ++P F++ E
Sbjct: 11164 HRFIADGKDRKLHIIDVQLS-DAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEV 11222
Query: 607 FSI-GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDN-IDFTSSLRISNLSLMHN 664
+ GQ +++ C + + + W+KDG+ + G + I +L I++
Sbjct: 11223 TVVKGQPLYLSCEL---NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDA 11279
Query: 665 GNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWK 724
G YT N +V V ++V+P + K + P I W
Sbjct: 11280 GTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKDTPNIKW- 11338
Query: 725 FSKGAGVPQFQPIALNGRIQVLSNGS---LLIKHVVEEDSGYYLCKV 768
KG +P N + ++L +G+ L IK+ + ED Y ++
Sbjct: 11339 -FKGYDEIPAEP---NDKTEILRDGNHLYLKIKNAMPEDIAEYAVEI 11381
Score = 43.9 bits (102), Expect = 0.002
Identities = 33/148 (22%), Positives = 60/148 (40%), Gaps = 7/148 (4%)
Query: 193 YNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDG---FDHRKAMAGQRVELPCKAL 249
Y +R I R+ + S S+ + ++ N P + G FD +G+ + +
Sbjct: 27924 YEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQ 27983
Query: 250 GHPEPDYRWLKDNMPLELSGRFQKT----VTGLLIENIRPSDSGSYVCEVSNRYGTAKVI 305
G P P W KD + +E + T T L + + G Y E N G+AK
Sbjct: 27984 GRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAE 28043
Query: 306 GRLYVKQPLKATISPRKVKSSVGSQVSL 333
++ V+ + P + + G +++L
Sbjct: 28044 IKVKVQDTPGKVVGPIRFTNITGEKMTL 28071
Score = 43.1 bits (100), Expect = 0.003
Identities = 35/195 (17%), Positives = 75/195 (38%), Gaps = 7/195 (3%)
Query: 499 INVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR---QVAFEN 555
+ + P +P++++ + G + G+P + W+++ ++ + Q++F +
Sbjct: 1 MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD 60
Query: 556 NGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQS---VHVTVKVPPFIQPFEFPRFSIGQR 612
+ + G Y+ +TS + V P F+Q + G +
Sbjct: 61 GRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ 120
Query: 613 VFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIAR 672
V + V P+ + + +DG I SL I SL I+ +G Y+ A
Sbjct: 121 VRLQVRVTGIPTPV-VKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNAT 179
Query: 673 NEAAAVEHQSQLIVR 687
N ++L+V+
Sbjct: 180 NSVGRATSTAELLVQ 194
Score = 42.7 bits (99), Expect = 0.004
Identities = 73/361 (20%), Positives = 127/361 (35%), Gaps = 59/361 (16%)
Query: 558 TLKLSDVQKEVDEGEYTCNVLVQPQ--LSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFI 615
TL D+ V +C ++ Q +S ++ ++++ P G V
Sbjct: 31528 TLIKKDLNMVVSAARISCGGAIRSQKGVSVAKVKVASIEIGPVSGQIMHAVGEEGGHVKY 31587
Query: 616 PCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEA 675
C + + D +TW R + S I D + L + +++ + +G Y C N+
Sbjct: 31588 VCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDY 31647
Query: 676 AAVEHQSQLIVRV----------------------------PPKFVVQPRDQDGIYGKAV 707
++L V+ PP+F + ++ G+ V
Sbjct: 31648 GEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENV 31707
Query: 708 ILNCSAEGYPVPTIVW-----KFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSG 762
+ +P P + W K G ++ + G Q L I V +D
Sbjct: 31708 RFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQ------LTINSVTTDDDA 31761
Query: 763 YYLCKVSNDVGADVSKSMYLTVKI---PAMITSYP--NTTLAT----QGQKKEMSCTAHG 813
Y N G D K+ LTV + P T P LA +GQ G
Sbjct: 31762 EYTVVARNKYGEDSCKAK-LTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSG 31820
Query: 814 EKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVIS--TLQILPTVREDSGFFSCHAINSY 871
P ++WEK+ + ++ L E+ E + L I T+ ED+G++ A N+
Sbjct: 31821 IPPPTLKWEKDGQPLS------LGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTA 31874
Query: 872 G 872
G
Sbjct: 31875 G 31875
Score = 42.7 bits (99), Expect = 0.004
Identities = 61/244 (25%), Positives = 86/244 (35%), Gaps = 50/244 (20%)
Query: 585 TSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT-ITWQKDGRPIPGSLGV 643
T + H+ V PP I F S + + CVV S L +TW KDG+ + +
Sbjct: 32706 TEKVQHLPVSAPPKITQFLKAEAS-KEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHF 32764
Query: 644 TID-NIDFTSSLRISNLSLMHNGNYTCIARNEAAA----VEHQSQLIVRVPPKF------ 692
+ D T L+I+NL+ G Y C E ++ Q + K
Sbjct: 32765 QFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISET 32824
Query: 693 --------------VVQPRDQDGIYGKAVILN----------------CSAEGYPVPTIV 722
+P+ + I K VI+ A G P PT +
Sbjct: 32825 KKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAI 32884
Query: 723 WKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVE-EDSGYYLCKVSNDVGADVSKSMY 781
W G + Q L+ G L H + DSG Y C V N G+ VS S
Sbjct: 32885 WT-KDGKAITQGGKYKLSED----KGGFFLEIHKTDTSDSGLYTCTVKNSAGS-VSSSCK 32938
Query: 782 LTVK 785
LT+K
Sbjct: 32939 LTIK 32942
Score = 42.4 bits (98), Expect = 0.005
Identities = 43/209 (20%), Positives = 79/209 (37%), Gaps = 11/209 (5%)
Query: 224 APSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSG------RFQKTVTG 277
AP+ + G G P P+ W +D + S F
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAK 64
Query: 278 LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSV---GSQVSLS 334
L I + ++SG Y + +N G A L VK ++++S GSQV L
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQ 124
Query: 335 CSVTGTEDQELSWYRNGEILNPGKNVRITGINH-ENLIMDHMVKSDGGAYQCFVRKDKLS 393
VTG + +YR+G + + +I+ +L++ D G Y
Sbjct: 125 VRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGR 184
Query: 394 AQDYVQVVLEDGTPKIISAFSEKVVSPAE 422
A +++++ G ++ + ++ +VS A+
Sbjct: 185 ATSTAELLVQ-GEEEVPAKKTKTIVSTAQ 212
Score = 42.4 bits (98), Expect = 0.005
Identities = 35/123 (28%), Positives = 51/123 (41%), Gaps = 12/123 (9%)
Query: 1279 EPLAKAPARILTFSGTVTTPWMKDIV--LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRR 1336
EP++ P + +G T D V KA G+P P W KD +T G+
Sbjct: 32846 EPISSKPVIV---TGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKA----ITQGGKY 32898
Query: 1337 SIFSN-GSFIIRTVKAE--DSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSS 1393
+ + G F + K + DSG Y+C N+ GS L ++ D VS +S
Sbjct: 32899 KLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTS 32958
Query: 1394 SIT 1396
IT
Sbjct: 32959 EIT 32961
Score = 42.0 bits (97), Expect = 0.006
Identities = 29/94 (30%), Positives = 40/94 (42%), Gaps = 7/94 (7%)
Query: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVT----GLLIENIRPSDSGSYVCE 294
G+ C G P P WL+ L S R Q T T I +++ SD G+Y
Sbjct: 32575 GESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVV 32634
Query: 295 VSNRYGTAKVIGRLYVKQPL---KATISPRKVKS 325
V N G + L +++ KA SP +VKS
Sbjct: 32635 VENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKS 32668
Score = 42.0 bits (97), Expect = 0.006
Identities = 28/99 (28%), Positives = 47/99 (47%), Gaps = 5/99 (5%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMKDS--NGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYS 1358
++++ C+ G+PSP ++W K++ S V+I R+++ S IR DSG Y+
Sbjct: 33149 QNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVY---SLEIRNASVSDSGKYT 33205
Query: 1359 CIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITL 1397
A N G +L V ++P V TS +L
Sbjct: 33206 IKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSL 33244
Score = 41.6 bits (96), Expect = 0.008
Identities = 53/258 (20%), Positives = 82/258 (31%), Gaps = 60/258 (23%)
Query: 249 LGHPEPDYRWLKDNMPLELSGRFQKT----VTGLLIENIRPSDSGSYVCEVSNRYGTAKV 304
+G P WL D PLE + R + L DSG C +N+YGT
Sbjct: 1729 IGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHT 1788
Query: 305 IGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITG 364
L VK + + G Q R E+ +TG
Sbjct: 1789 SATLIVKDEKSLVEESQLPEGRKGLQ------------------RIEELERMAHEGALTG 1830
Query: 365 INHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPV 424
+ + +K+K P I+ V E
Sbjct: 1831 VTTD-------------------QKEKQK-------------PDIVLYPEPVRVLEGETA 1858
Query: 425 SLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRC 484
C V G P P + W L+ I K R+ + + YL+I + D G +
Sbjct: 1859 RFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRY------DGIHYLDIVDCKSYDTGEVKV 1912
Query: 485 TANNSAGVVLYQARINVR 502
TA N GV+ ++ ++ ++
Sbjct: 1913 TAENPEGVIEHKVKLEIQ 1930
Score = 41.6 bits (96), Expect = 0.008
Identities = 84/374 (22%), Positives = 139/374 (37%), Gaps = 63/374 (16%)
Query: 235 KAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKT--VTGLLIENIRPSDSGSYV 292
+A R+ +P K G P P+ +W +D+ + T T L++ N+ DSG Y+
Sbjct: 21873 RACCTLRLFVPIK--GRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYI 21930
Query: 293 CEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGE 352
V N G+ + V L P+ +K ++ S++ L+W +
Sbjct: 21931 LTVENSSGSKSAFVNVRV---LDTPGPPQDLKVKEVTKTSVT----------LTW--DPP 21975
Query: 353 ILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISA 412
+L+ G ++ N I++ +S AY ++ Q L++G
Sbjct: 21976 LLDGGSKIK-------NYIVEKR-ESTRKAYSTVATNCHKTSWKVDQ--LQEGCSYYFRV 22025
Query: 413 FSEKVVSPAEPVSLMCNVKGT--PLPTITWTLDD-----------DPILKGGSHRISQMI 459
+E P +VK + PLP TL D P GGS + ++
Sbjct: 22026 LAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIV 22085
Query: 460 TSEGN---------VVSYLNISSSQVRDGGVY--RCTANNSAGV-------VLYQARINV 501
+ V + + + G Y R +A N G+ V A+ V
Sbjct: 22086 EMQTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLV 22145
Query: 502 RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVA--FENNGTL 559
PA T +AG D + IG P ++ W+K++ L R A ENN L
Sbjct: 22146 IPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLL 22205
Query: 560 KLSDVQKEVDEGEY 573
+ D +E D G Y
Sbjct: 22206 TIKDACRE-DVGHY 22218
Score = 41.6 bits (96), Expect = 0.008
Identities = 39/135 (28%), Positives = 60/135 (44%), Gaps = 9/135 (6%)
Query: 210 SNSARLFVSDPAN-SAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELS 268
S +A L V PA P L+G A+ G+ V + G P+P W K ++ +
Sbjct: 31012 SGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNN 31071
Query: 269 GRFQ----KTVTGLLIEN-IRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKV 323
G +Q ++ T L+ N + D+G YV NR+G + L V PR V
Sbjct: 31072 GHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVAD---VPDPPRGV 31128
Query: 324 KSSVGSQVSLSCSVT 338
K S S+ S++ + T
Sbjct: 31129 KVSDVSRDSVNLTWT 31143
Score = 41.6 bits (96), Expect = 0.008
Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 11/110 (10%)
Query: 1286 ARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFS---NG 1342
ARILT ++T + C G+P P V W++ +++ R + +
Sbjct: 32561 ARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKG----QVLSTSARHQVTTTKYKS 32616
Query: 1343 SFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTS 1392
+F I +V+A D G YS + N+ G E L +Q + R+T TS
Sbjct: 32617 TFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ----KARVTEKAVTS 32662
Score = 41.2 bits (95), Expect = 0.010
Identities = 31/108 (28%), Positives = 48/108 (44%), Gaps = 5/108 (4%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNG-- 1342
P +++ VT + + L C G PSP V W ++ S + + F +G
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDF---QITFQSGIA 998
Query: 1343 SFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKT 1390
+IR AEDSG ++C A N G+ L VQV + + T + T
Sbjct: 999 RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVT 1046
Score = 41.2 bits (95), Expect = 0.010
Identities = 30/81 (37%), Positives = 35/81 (43%), Gaps = 6/81 (7%)
Query: 1308 KAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGS---FIIRTVKAEDSGYYSCIANNN 1364
K GDP P VKW K G + GR I G IR DSG Y C+A N
Sbjct: 8476 KVGGDPIPNVKWTK---GKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNE 8532
Query: 1365 WGSDEIILNLQVQVPPDQPRL 1385
G E +NLQV Q ++
Sbjct: 8533 HGEIESNVNLQVDERKKQEKI 8553
Score = 41.2 bits (95), Expect = 0.010
Identities = 33/126 (26%), Positives = 54/126 (42%), Gaps = 12/126 (9%)
Query: 189 EDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAM---AGQRVELP 245
ED Y +R I R+ + S+S+ + AP+ ++ + AG+ L
Sbjct: 24669 EDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGETFVLE 24728
Query: 246 CKALGHPEPDYRWLKDNMPL-------ELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNR 298
G P PD W KD L E+ QKT L++++ +D G Y+ ++SN
Sbjct: 24729 ADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTT--LVVKDCIRTDGGQYILKLSNV 24786
Query: 299 YGTAKV 304
GT +
Sbjct: 24787 GGTKSI 24792
Score = 41.2 bits (95), Expect = 0.010
Identities = 92/490 (18%), Positives = 176/490 (35%), Gaps = 87/490 (17%)
Query: 104 AENPSGKIR----SQDVHIKAVLREPYTVRVE--DQKTMRGNVAVFKCIIPSSVEAYITV 157
AEN +G R + + K E +R E D T G A C I V +
Sbjct: 30507 AENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQI---VGRPLPD 30563
Query: 158 VSWEKDTVSLVSGSRFLITSTGALYIKDV----QNEDGLYNYRCITRHRYTGETRQSNSA 213
+ W + L+ ++ ++S G + V Q ++G+Y CI + GE S+
Sbjct: 30564 IKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYT--CIATNE-VGEVETSSKL 30620
Query: 214 RLFVSDPANSAPSILDGFDHRK---AMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGR 270
L + P G+ ++ G + L +G P P W L+ S
Sbjct: 30621 LL------QATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSEN 30674
Query: 271 FQ----KTVTGLLIENI-RPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKS 325
+ T L+++N+ R + +G Y ++SN +GT I + ++ P +++
Sbjct: 30675 ITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKPDKPTGPIVIEA 30734
Query: 326 SVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQC 385
+ + +S D SW N +++ +G +Q
Sbjct: 30735 LLKNSAVISWKPPA--DDGGSWI-------------------TNYVVEKCEAKEGAEWQL 30773
Query: 386 FVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVK------GTP-LPTI 438
++ V + G +SA + +S VS + +K G P PTI
Sbjct: 30774 VSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTI 30833
Query: 439 TWTLDDD-------PILKGGSH-RISQMITSEGNVVSYLNISSSQVRDGGV--------- 481
T D P GG+ R + E ++++++ ++R+
Sbjct: 30834 TAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVFSVKNLIEGL 30893
Query: 482 ---YRCTANNSAG---------VVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIG 529
+R N G + ++ + ++ P ++N+ + + C+V G
Sbjct: 30894 EYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTG 30953
Query: 530 YPYYSIKWYK 539
+P +KWY+
Sbjct: 30954 HPKPIVKWYR 30963
Score = 40.8 bits (94), Expect = 0.014
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 8/135 (5%)
Query: 205 GETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMP 264
G + +++A L V + P+ + G +V L + G P P ++ +D
Sbjct: 85 GSGQATSTAELLVK-AETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAE 143
Query: 265 LELSGRFQKTVTG----LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP 320
++ S FQ + G LLI P DSG+Y +N G A L V+ + +
Sbjct: 144 IQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQG--EEEVPA 201
Query: 321 RKVKSSVG-SQVSLS 334
+K K+ V +Q+S S
Sbjct: 202 KKTKTIVSTAQISES 216
Score = 40.8 bits (94), Expect = 0.014
Identities = 49/267 (18%), Positives = 98/267 (36%), Gaps = 16/267 (5%)
Query: 315 KATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRIT---GINHENLI 371
+ T+ R + G +V E+ WY NG L + T G+ ++
Sbjct: 32375 RITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEIL 32434
Query: 372 MDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVK 431
H D G Y+ K A DY + + G + ++ + P S+ +
Sbjct: 32435 DCHT--DDSGTYRAVCTNYKGEASDYATLDVTGGD---YTTYASQRRDEEVPRSVFPELT 32489
Query: 432 GTPLPTITWTLDDDPILKGGSHRI--SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNS 489
T ++ + S R SQM + ++ SY + +S++++ + +
Sbjct: 32490 RTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEK 32549
Query: 490 AGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFN-- 547
+ + + R + +++T G C G P ++ W + +L +
Sbjct: 32550 STTRKIKTTLAAR---ILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSAR 32606
Query: 548 HRQVAFENNGTLKLSDVQKEVDEGEYT 574
H+ + T ++S VQ DEG Y+
Sbjct: 32607 HQVTTTKYKSTFEISSVQAS-DEGNYS 32632
Score = 40.4 bits (93), Expect = 0.018
Identities = 55/244 (22%), Positives = 95/244 (38%), Gaps = 23/244 (9%)
Query: 249 LGHPEPDYRWLKDNMPLELSGRFQKTVTG----LLIENIRPSDSGSYVCEVSNRYGTAKV 304
+ +PE W K LE S +F+ ++ G L ++N + D G+Y +AK
Sbjct: 8681 INYPEIKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRLVCGPHIASAK- 8739
Query: 305 IGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITG 364
L V +P + V G +++C + + + W+RNG IL P + T
Sbjct: 8740 ---LTVIEPAWER-HLQDVTLKEGQTCTMTCQFS-VPNVKSEWFRNGRILKP-QGRHKTE 8793
Query: 365 INHE--NLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAE 422
+ H+ L + + D G Y C + SA+ ++ T +I VVS +
Sbjct: 8794 VEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQFTKRI----QNIVVSEHQ 8849
Query: 423 PVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVY 482
+ C V +TW + + + ++G Y+ I + D GVY
Sbjct: 8850 SATFECEVSFDD-AIVTWYKGPTELTESQKYN----FRNDGR-CHYMTIHNVTPDDEGVY 8903
Query: 483 RCTA 486
A
Sbjct: 8904 SVIA 8907
Score = 40.4 bits (93), Expect = 0.018
Identities = 60/273 (21%), Positives = 98/273 (35%), Gaps = 36/273 (13%)
Query: 777 SKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYL 836
S + + + A I + P + +G+ SC GE V W ++ ++++ +
Sbjct: 32550 STTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQV 32609
Query: 837 VSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDV 896
+TK ST +I D G +S NS G+ LT+Q
Sbjct: 32610 TTTK-----YKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ------------- 32651
Query: 897 KARTITLRWTMGFDGNSPITGYDIECKNKS-DSWDSAQRTKDVSPQLNSATIIDIHPSST 955
KAR T SP E + KS ++ S +R K P A + P+ T
Sbjct: 32652 KARVTEKAVT------SPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKA----VSPTET 32701
Query: 956 YSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTW-KAPKKHLQN 1014
+ S P EA+ + +E ++ VTW K KK +N
Sbjct: 32702 KPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKEN 32761
Query: 1015 GIIRGYQIGYREYSTGGNFQFNIISVDTSGDSE 1047
G + + YS G ++ I ++ S E
Sbjct: 32762 GHFQFH------YSADGTYELKINNLTESDQGE 32788
Score = 40.0 bits (92), Expect = 0.023
Identities = 29/91 (31%), Positives = 40/91 (43%), Gaps = 8/91 (8%)
Query: 417 VVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQV 476
VV V ++G P+PT WT D I K H N S L I +
Sbjct: 17521 VVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI-KTDEH----YTVETDNFSSVLTIKNCLR 17575
Query: 477 RDGGVYRCTANNSAG---VVLYQARINVRGP 504
RD G Y+ T +N+AG V ++ ++V GP
Sbjct: 17576 RDTGEYQITVSNAAGSKTVAVHLTVLDVPGP 17606
Score = 39.7 bits (91), Expect = 0.030
Identities = 53/246 (21%), Positives = 85/246 (34%), Gaps = 62/246 (25%)
Query: 302 AKVIGRLYVKQPLKATISPRKVKSSV-------GSQVSLSCSVTGTEDQELSWYRNGEIL 354
AKV V P++ ++P + S + G V+L C ++G ++WYR +
Sbjct: 924 AKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQI 983
Query: 355 NPGKNVRIT---GINHENLIMDHMVKSDGGAYQCFVRKD--KLSAQDYVQVVLEDGTPKI 409
+ +IT GI L++ D G + C + +S Y+ V + + K
Sbjct: 984 ESSIDFQITFQSGI--ARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKE 1041
Query: 410 ISAFSEKVVS------------------------PAEP-------------------VSL 426
+A +EK + P EP V
Sbjct: 1042 TTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVF 1101
Query: 427 MCNVKGTPLPTITWTLDDDPILKGGSHRIS-QMITSEGNVVSYLNISSSQVRDGGVYRCT 485
C V G P P + W P+ G +++S T E +V IS + D G Y
Sbjct: 1102 GCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLV----ISMTFADDAGEYTIV 1157
Query: 486 ANNSAG 491
N G
Sbjct: 1158 VRNKHG 1163
Score = 39.7 bits (91), Expect = 0.030
Identities = 29/109 (26%), Positives = 52/109 (47%), Gaps = 6/109 (5%)
Query: 231 FDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LLIENIRPS 286
F+ +AG+ +++ +G P P W KDN+PL+ + R T L I++
Sbjct: 22154 FNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACRE 22213
Query: 287 DSGSYVCEVSNRYGTA-KVIGRLYVKQPLKATISPRKVKSSVGSQVSLS 334
D G YV +++N G A + + + + +P T P K+ ++LS
Sbjct: 22214 DVGHYVVKLTNSAGEAIETLNVIVLDKPGPPT-GPVKMDEVTADSITLS 22261
Score = 39.7 bits (91), Expect = 0.030
Identities = 43/186 (23%), Positives = 71/186 (38%), Gaps = 34/186 (18%)
Query: 751 LLIKHVVEEDSGYYLCKVSNDVGADVSKSMYL----------TVKIPAMITSYPNTTLAT 800
L I ++ E D G Y+C++S + G + ++ KI S TT +T
Sbjct: 32776 LKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTEST 32835
Query: 801 QGQKKEMSCTAH-GEKPIIVRWEKEDRIINPEMARYLV-STKEVGEEVIST--------- 849
+K E KP+IV ++ + + +A++ V +T E I T
Sbjct: 32836 VTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQG 32895
Query: 850 -------------LQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDV 896
L+I T DSG ++C NS G +LT++ D ++
Sbjct: 32896 GKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQ 32955
Query: 897 KARTIT 902
K IT
Sbjct: 32956 KTSEIT 32961
Score = 39.3 bits (90), Expect = 0.039
Identities = 117/627 (18%), Positives = 228/627 (36%), Gaps = 80/627 (12%)
Query: 327 VGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRIT--GINHENLIMDHMVKSDGGAYQ 384
VGS C V+ + +W ++G + R G + + I+D + SD G Y
Sbjct: 11132 VGSSAIFECLVSPST-AITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQL-SDAGEYT 11189
Query: 385 CFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKV-VSPAEPVSLMCNVKGTPLPTITWTLD 443
C +R ++V+E+ + + E+V V +P+ L C + + W D
Sbjct: 11190 CVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELNKE--RDVVWRKD 11247
Query: 444 DDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQA--RINV 501
+++ + +I ++ L I+ + D G Y T N+ + + V
Sbjct: 11248 GKIVVEKPGRIVPGVI----GLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEV 11303
Query: 502 RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPF------------NHR 549
++P+++ + + T I I +IKW+K + +P NH
Sbjct: 11304 IRDWLVKPIRD-QHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILRDGNHL 11362
Query: 550 QVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSI 609
+ +N +++ E++ Y + + + ++P E
Sbjct: 11363 YLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGE------------REVELLKPIEDVTIYE 11410
Query: 610 GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTC 669
+ + D+P W+ G + S I L + + L G
Sbjct: 11411 KESASFDAEISEADIP--GQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLY 11468
Query: 670 IARN---EAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFS 726
A N A + +L VP K V P + + +L A ++W S
Sbjct: 11469 QALNAITTAILTVKEIELDFAVPLKDVTVPERRQARF--ECVLTREA------NVIW--S 11518
Query: 727 KGAGVPQFQPIALNGRIQVLSNGS---LLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLT 783
KG + I + + ++++G L+I +D G Y +V G S +++T
Sbjct: 11519 KGPDI-----IKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVE---GKKTSARLFVT 11570
Query: 784 -VKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDR--------IINPEMAR 834
+++ M T +G+ C EK +V W K D +I+ E
Sbjct: 11571 GIRLKFMSPLEDQT--VKEGETATFVCELSHEKMHVV-WFKNDAKLHTSRTVLISSEGKT 11627
Query: 835 YLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIK 894
+ + KEV + IS QI V+E S + + + ++L + + EI +K
Sbjct: 11628 HKLEMKEVTLDDIS--QIKAQVKELSSTAQLKVLEA--DPYFTVKLHDKTAVEKDEITLK 11683
Query: 895 DVKARTITLRWTMGFDGNSPITGYDIE 921
++ + ++W + P Y I+
Sbjct: 11684 CEVSKDVPVKWFKDGEEIVPSPKYSIK 11710
Score = 38.5 bits (88), Expect = 0.067
Identities = 32/128 (25%), Positives = 58/128 (45%), Gaps = 8/128 (6%)
Query: 1261 VVAVTSAGRGNSSEIITVEPLA-KAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKW 1319
VVA AGR + S I+TVE + + + V + + +A G+P+P + W
Sbjct: 1530 VVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVW 1589
Query: 1320 MKDSN----GTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQ 1375
+K+S+ + I+G + + I + ++DS +Y+ A N G D +
Sbjct: 1590 LKNSDIIVPHKYPKIRIEGTK---GEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVN 1646
Query: 1376 VQVPPDQP 1383
V+V +P
Sbjct: 1647 VEVEFAEP 1654
Score = 38.5 bits (88), Expect = 0.067
Identities = 24/87 (27%), Positives = 43/87 (49%), Gaps = 12/87 (13%)
Query: 424 VSLMCNVKGTPLPTITWTL-------DDDPILKGGSHRISQMITSEGNVVSYLNISSSQV 476
V+++ +KG P PT+TW + +P+L +++++ + L I S+
Sbjct: 16134 VNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLY--DTHVNKLVVDD---TCTLVIPQSRR 16188
Query: 477 RDGGVYRCTANNSAGVVLYQARINVRG 503
D G+Y TA N+ G + R+NV G
Sbjct: 16189 SDTGLYTITAVNNLGTASKEMRLNVLG 16215
Score = 38.5 bits (88), Expect = 0.067
Identities = 34/153 (22%), Positives = 56/153 (36%), Gaps = 7/153 (4%)
Query: 189 EDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAM---AGQRVELP 245
ED Y +R R+ + S S + P ++ R + AG+ +++
Sbjct: 25751 EDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKIN 25810
Query: 246 CKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LLIENIRPSDSGSYVCEVSNRYGT 301
G P P W KD + +E R + T L +++ D+G YV + N GT
Sbjct: 25811 ADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGT 25870
Query: 302 AKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS 334
V V P ++ + SLS
Sbjct: 25871 RSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLS 25903
Score = 38.5 bits (88), Expect = 0.067
Identities = 63/307 (20%), Positives = 109/307 (35%), Gaps = 28/307 (9%)
Query: 404 DGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEG 463
D P+I V + + NV+ P + W + + + S +I TS
Sbjct: 32371 DHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQE--SSKIHYTNTSG- 32427
Query: 464 NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAIAG--RDT 521
V L I D G YR N G A ++V G + T A RD
Sbjct: 32428 --VLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGG-------DYTTYASQRRDE 32478
Query: 522 YIHCRVIGY----PYYSIKWYKNSNLLPFNH--RQVAFENNGTLKLSDVQKEVDEGEYTC 575
+ V Y++ +K ++ + + R+V + T + + E
Sbjct: 32479 EVPRSVFPELTRTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKS 32538
Query: 576 NVLVQPQL---STSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQK 632
L + L ST++ + T+ +P + G+ C +P T+TW +
Sbjct: 32539 AALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYE-GESARFSCDTDGEPVP-TVTWLR 32596
Query: 633 DGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV---RVP 689
G+ + S + + S+ IS++ GNY+ + N E + L + RV
Sbjct: 32597 KGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVT 32656
Query: 690 PKFVVQP 696
K V P
Sbjct: 32657 EKAVTSP 32663
Score = 38.1 bits (87), Expect = 0.088
Identities = 29/138 (21%), Positives = 57/138 (41%), Gaps = 7/138 (5%)
Query: 407 PKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV 466
P VV + ++ G P+P ++W D ++ + Q+ S+G
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSW-FRDGQVISTSTLPGVQISFSDGR-- 62
Query: 467 SYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG----PASIRPMKNITAIAGRDTY 522
+ L I + + G Y A N +G A + V+ P ++ ++++T G
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVR 122
Query: 523 IHCRVIGYPYYSIKWYKN 540
+ RV G P +K+Y++
Sbjct: 123 LQVRVTGIPTPVVKFYRD 140
Score = 38.1 bits (87), Expect = 0.088
Identities = 33/123 (26%), Positives = 49/123 (39%), Gaps = 23/123 (18%)
Query: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAE--DSGYYSCIAN 1362
L CK G V W KD + D R F G+ + ++ + D+G ++C A
Sbjct: 4132 LDCKIAGSLPMRVSWFKDGK---EIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTCRAT 4188
Query: 1363 NNWGSDEIILNLQVQVPPDQPRLTVSKTT--------------SSSITLSWLPGD----N 1404
N+ GS + L VQ PP SK S+ +T+ W G+ +
Sbjct: 4189 NSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVS 4248
Query: 1405 GGS 1407
GGS
Sbjct: 4249 GGS 4251
Score = 38.1 bits (87), Expect = 0.088
Identities = 31/124 (25%), Positives = 48/124 (38%), Gaps = 7/124 (5%)
Query: 189 EDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAM---AGQRVELP 245
ED Y +R I ++ + S + AP I + + AG+ L
Sbjct: 21423 EDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLE 21482
Query: 246 CKALGHPEPDYRWLKDNMPLELSGRFQKTV----TGLLIENIRPSDSGSYVCEVSNRYGT 301
G P P W KD LE + + + + T L+ ++ DSG+Y +N G
Sbjct: 21483 ADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGF 21542
Query: 302 AKVI 305
AK I
Sbjct: 21543 AKHI 21546
Score = 37.7 bits (86), Expect = 0.11
Identities = 29/110 (26%), Positives = 45/110 (40%), Gaps = 6/110 (5%)
Query: 774 ADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMA 833
A V + + V P +++ N T+ +G+ + C G V W +ED I
Sbjct: 930 ARVPAPVEIPVTPPTLVSGLKNVTVI-EGESVTLECHISGYPSPTVTWYREDYQIESS-- 986
Query: 834 RYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQ 883
+ + + I+ L I EDSG F+C A+N G L VQ
Sbjct: 987 ---IDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQ 1033
Score = 37.7 bits (86), Expect = 0.11
Identities = 35/124 (28%), Positives = 51/124 (41%), Gaps = 15/124 (12%)
Query: 1267 AGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKD---- 1322
AGR SS +T+ A P ++L VT K G P P + W K+
Sbjct: 3222 AGRNRSS--VTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLL 3279
Query: 1323 SNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVP--- 1379
S G DG+ + ++ ED+ Y+C A N++G +L V+VP
Sbjct: 3280 STGFKCKFLHDGQEY-----TLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVV 3334
Query: 1380 -PDQ 1382
PDQ
Sbjct: 3335 SPDQ 3338
Score = 37.7 bits (86), Expect = 0.11
Identities = 54/212 (25%), Positives = 80/212 (37%), Gaps = 48/212 (22%)
Query: 1295 VTTPWMKDIVLPCKAV-------GDPSPAVKWMKDS----NGTPSLVTIDGRRSIFSNGS 1343
VT P KD VLP AV G ++W K + +G +T + S S
Sbjct: 4209 VTKPGSKD-VLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALES-----S 4262
Query: 1344 FIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP---------------DQPRLTVS 1388
+ VK DSG Y+C +N G E NL V+ P D +L
Sbjct: 4263 LELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACK 4322
Query: 1389 KTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYK 1448
T + I ++W D + +++S+ SF S RL ++ +
Sbjct: 4323 VTGTPPIKITWFAND-----------REIKESSKHRMSF--VESTAVLRLTDVGIEDSGE 4369
Query: 1449 FTLTAQNGVGPGRISEIIEAKTLGKEPQFSKE 1480
+ AQN G S I+ K + P F+KE
Sbjct: 4370 YMCEAQNEAGSDHCSSIVIVK---ESPYFTKE 4398
Score = 37.0 bits (84), Expect = 0.20
Identities = 44/148 (29%), Positives = 54/148 (36%), Gaps = 24/148 (16%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSI-FSN-- 1341
PA I+ ++ L C G P + KW KD +T D + I F N
Sbjct: 7585 PATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKE----LTSDNKYKISFFNKV 7640
Query: 1342 GSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQ---VPPDQPR-------LTVSKTT 1391
I V DSG YS N G D +LQV VPP R L+ S
Sbjct: 7641 SGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVV 7700
Query: 1392 -------SSSITLSWLPGDNGGSSIRGY 1412
S I++SW N SS R Y
Sbjct: 7701 MECKVYGSPPISVSWFHEGNEISSGRKY 7728
Score = 37.0 bits (84), Expect = 0.20
Identities = 39/153 (25%), Positives = 59/153 (38%), Gaps = 17/153 (11%)
Query: 160 WEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSD 219
W K ++VS + F +T+ +E Y +R + ++ ++ S S
Sbjct: 28988 WLKCNYTIVSDNFFTVTAL---------SEGDTYEFRVLAKNAAGVISKGSESTGPVTCR 29038
Query: 220 PANSAPSI-LDGFDHRKAM---AGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV 275
+ P LD H + AG + L G PEP W K + L+L +
Sbjct: 29039 DEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQY 29098
Query: 276 TG----LLIENIRPSDSGSYVCEVSNRYGTAKV 304
TG +I+ SDSG Y V N GT V
Sbjct: 29099 TGKRATAVIKFCDRSDSGKYTLTVKNASGTKAV 29131
Score = 37.0 bits (84), Expect = 0.20
Identities = 24/97 (24%), Positives = 43/97 (44%), Gaps = 7/97 (7%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNG-- 1342
P +I ++ K + + C G+P+P V W S G + + + R N
Sbjct: 33328 PPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTW---SCGGRKIHSQEQGRFHIENTDD 33384
Query: 1343 --SFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQ 1377
+ II V+ +D G Y+ N +GSD +N+ ++
Sbjct: 33385 LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIR 33421
Score = 36.6 bits (83), Expect = 0.25
Identities = 54/224 (24%), Positives = 85/224 (37%), Gaps = 16/224 (7%)
Query: 94 LIHDNTYY--CTAENPSGKIRSQDVHIKAVLREPYTV--RVEDQ--KTMRGNVAVFKCII 147
LI Y+ AEN G + V+REP TV R ED K + N
Sbjct: 16680 LIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWN- 16738
Query: 148 PSSVEAYITVVSWEKDTVSLVSGSRFLITSTGAL---YIKDVQNEDGLYNYRCITRHRYT 204
P + ++++ ++ + + +T+ L Y E Y YR ++
Sbjct: 16739 PPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYR-VSAVNIV 16797
Query: 205 GETRQSNSARLFVSDPANSAPSI-LDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNM 263
G+ + S + + P++ LD D G+ L + G P+P W KD
Sbjct: 16798 GQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEA 16857
Query: 264 PLELSGR--FQKTVTGLLIENIRP--SDSGSYVCEVSNRYGTAK 303
+ R + T L +E I+ SDSG Y V N G+ K
Sbjct: 16858 DVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRK 16901
Score = 36.6 bits (83), Expect = 0.25
Identities = 22/77 (28%), Positives = 35/77 (45%), Gaps = 7/77 (9%)
Query: 415 EKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSS 474
E+ + + + L +KG P P +TW +D + + +T G S L I ++
Sbjct: 17227 EQHIKVGDTLRLSAIIKGVPFPKVTWKKED----RDAPTKARIDVTPVG---SKLEIRNA 17279
Query: 475 QVRDGGVYRCTANNSAG 491
DGG+Y T N AG
Sbjct: 17280 AHEDGGIYSLTVENPAG 17296
Score = 36.2 bits (82), Expect = 0.33
Identities = 29/118 (24%), Positives = 51/118 (43%), Gaps = 18/118 (15%)
Query: 667 YTCIARNEAAAVEHQS--------QLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPV 718
++ A ++AA+E +S ++ + + + +PR G++ +C +G PV
Sbjct: 32530 HSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPV 32589
Query: 719 PTIVWKFSKGAGVPQFQPIALNGRIQVLS---NGSLLIKHVVEEDSGYYLCKVSNDVG 773
PT+ W KG Q ++ + R QV + + I V D G Y V N G
Sbjct: 32590 PTVTW-LRKG------QVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEG 32640
Score = 35.4 bits (80), Expect = 0.57
Identities = 64/270 (23%), Positives = 104/270 (38%), Gaps = 53/270 (19%)
Query: 1310 VGDPSP-AVKWMKDSNGTPSLVTIDGRRSIFSNG---SFIIRTVKAEDSGYYSCIANNNW 1365
VG +P +KW KD+ S RS++ + S + KA DSG Y C +N+
Sbjct: 4791 VGGTAPMTIKWFKDNKELHS----GAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDV 4846
Query: 1366 GSDEIILNLQVQVPPD-----QPRLTVSK----------TTSSSITLSWLPGDNGGSSIR 1410
G+ L V+ PP P L + T + I +SW N ++I+
Sbjct: 4847 GTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQ 4906
Query: 1411 GYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKT 1470
+ + + + +F IS + R+EN GT + A+N G S ++ K
Sbjct: 4907 KHGISFIDG----LATFQISGA----RVEN--SGT---YVCEARNDAGTASCSIELKVK- 4952
Query: 1471 LGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLS 1530
+ P F +E + + + V L C +T PF T + S
Sbjct: 4953 --EPPTFIRELKPVEVVKYSDVELE--------CEVTGTP----PFEVTWLKNNREIRSS 4998
Query: 1531 KSYILYDLQEATWYELQMRVCNSAGCAEKQ 1560
K Y L D + + L + C+ + E Q
Sbjct: 4999 KKYTLTD--RVSVFNLHITKCDPSDTGEYQ 5026
Score = 35.4 bits (80), Expect = 0.57
Identities = 35/121 (28%), Positives = 46/121 (38%), Gaps = 11/121 (9%)
Query: 225 PSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLK------DNM-PLELSGRFQKTVTG 277
P +D + + G V + K G P P W K DN P+ K V
Sbjct: 16117 PPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVD 16176
Query: 278 ----LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSL 333
L+I R SD+G Y N GTA RL V + P K +S Q++L
Sbjct: 16177 DTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTL 16236
Query: 334 S 334
S
Sbjct: 16237 S 16237
Score = 35.4 bits (80), Expect = 0.57
Identities = 36/181 (19%), Positives = 70/181 (38%), Gaps = 16/181 (8%)
Query: 160 WEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSD 219
W K + + V+ ++F+I+ ++ Y +R R+ + S
Sbjct: 26814 WTKASFTNVTETQFIISGL---------TQNSQYEFRVFARNAVGSISNPSEVVGPITCI 26864
Query: 220 PANSAPSI---LDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSG----RFQ 272
+ P I L+ + K AG V+L G P P W KD+ L+ +
Sbjct: 26865 DSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENT 26924
Query: 273 KTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVS 332
+ +LI++ +SG Y ++ N G+A R+ + P + K+ +++
Sbjct: 26925 TDLASILIKDADRLNSGCYELKLRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKIT 26984
Query: 333 L 333
L
Sbjct: 26985 L 26985
Score = 35.4 bits (80), Expect = 0.57
Identities = 22/77 (28%), Positives = 31/77 (40%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
+ + + G P P +KW KD I+ + IR ED+GYY
Sbjct: 31810 QSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVT 31869
Query: 1361 ANNNWGSDEIILNLQVQ 1377
A N GS +LQV+
Sbjct: 31870 ATNTAGSTSCQAHLQVE 31886
Score = 35.0 bits (79), Expect = 0.74
Identities = 41/148 (27%), Positives = 60/148 (40%), Gaps = 18/148 (12%)
Query: 189 EDGLYNYR-CITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAM---AGQRVEL 244
E+ YN+R C GE + V+ P I D RK + A + L
Sbjct: 25070 ENTEYNFRICAINSEGVGEPATLPGS--VVAQERIEPPEIELDADLRKVVVLRASATLRL 25127
Query: 245 PCKALGHPEPDYRW------LKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNR 298
G PEP+ +W L D +E++ F T L+I+N+ DSG Y + N
Sbjct: 25128 FVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSF----TMLVIDNVTRFDSGRYNLTLENN 25183
Query: 299 YG--TAKVIGRLYVKQPLKATISPRKVK 324
G TA V R+ ++ R+VK
Sbjct: 25184 SGSKTAFVNVRVLDSPSAPVNLTIREVK 25211
Score = 34.7 bits (78), Expect = 0.97
Identities = 35/132 (26%), Positives = 55/132 (41%), Gaps = 14/132 (10%)
Query: 1267 AGRGNSSEIITVEPLAKA---PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDS 1323
A G+ T E L KA P + ++T + L + G P+P VK+ +D
Sbjct: 82 ATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDG 141
Query: 1324 NGTPSLVTIDGRRSIFSNG---SFIIRTVKAEDSGYYSCIANNNWG----SDEIILNLQV 1376
S + I G S +I EDSG YS A N+ G + E+++ +
Sbjct: 142 AEIQSSLDFQ----ISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEE 197
Query: 1377 QVPPDQPRLTVS 1388
+VP + + VS
Sbjct: 198 EVPAKKTKTIVS 209
Score = 34.7 bits (78), Expect = 0.97
Identities = 28/123 (22%), Positives = 49/123 (39%), Gaps = 7/123 (5%)
Query: 189 EDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAM---AGQRVELP 245
ED Y +R I R+ + S S + P I ++ + AG+ ++
Sbjct: 22505 EDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFKVD 22564
Query: 246 CKALGHPEPDYRWLKDNMPLELSGRFQ----KTVTGLLIENIRPSDSGSYVCEVSNRYGT 301
G P P +W+K + L + R + T L +++ DSG+Y+ + N G
Sbjct: 22565 ADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGE 22624
Query: 302 AKV 304
V
Sbjct: 22625 RSV 22627
Score = 34.7 bits (78), Expect = 0.97
Identities = 29/120 (24%), Positives = 48/120 (40%), Gaps = 7/120 (5%)
Query: 189 EDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAM---AGQRVELP 245
ED Y +R I ++ ++ S+S + P I R + AG+ L
Sbjct: 23587 EDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLE 23646
Query: 246 CKALGHPEPDYRWLKDNMPLELSGRFQKTVTG----LLIENIRPSDSGSYVCEVSNRYGT 301
G P P WL+ + +E S R + T L++++ D G Y+ SN G+
Sbjct: 23647 ADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGS 23706
Score = 34.3 bits (77), Expect = 1.3
Identities = 27/100 (27%), Positives = 43/100 (43%), Gaps = 8/100 (8%)
Query: 418 VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVR 477
V + + ++ VKG P P ITWT + +++ + Q + L I +
Sbjct: 17920 VRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPR-----VELQIKEAVRA 17974
Query: 478 DGGVYRCTANNSAGVVLYQARINV---RGPASIRPMKNIT 514
D G Y +A NS+G A +NV GP + N+T
Sbjct: 17975 DHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVTNVT 18014
Score = 33.9 bits (76), Expect = 1.7
Identities = 19/61 (31%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 513 ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHR-QVAFENNGTLKLSDVQKEVDEG 571
+ + G CRV GYP + WY N L+ + R +V ++ L + D K D G
Sbjct: 1850 VRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVDC-KSYDTG 1908
Query: 572 E 572
E
Sbjct: 1909 E 1909
Score = 33.9 bits (76), Expect = 1.7
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 8/99 (8%)
Query: 396 DYVQVVLEDGTPKIISAFSEK---VVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS 452
D V ++ E+ P+I + + K V V L V G P+PT++W D +LK
Sbjct: 19282 DPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWK-KDGTLLKPAE 19340
Query: 453 HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAG 491
+ + N+ + L + S +D G Y TA NS+G
Sbjct: 19341 ---GIKMAMQRNLCT-LELFSVNRKDSGDYTITAENSSG 19375
Score = 33.9 bits (76), Expect = 1.7
Identities = 28/118 (23%), Positives = 51/118 (43%), Gaps = 14/118 (11%)
Query: 193 YNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAM---AGQRVELPCKAL 249
YN+R ++ G ++ + + AP I + RK + AG + L
Sbjct: 22909 YNFRICAINK-AGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIK 22967
Query: 250 GHPEPDYRW------LKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGT 301
G P P+ +W ++D ++++ F T L+++N+ DSG Y + N GT
Sbjct: 22968 GRPTPEVKWGKVDGEIRDAAIIDVTSSF----TSLVLDNVNRYDSGKYTLTLENSSGT 23021
Score = 33.5 bits (75), Expect = 2.2
Identities = 25/84 (29%), Positives = 35/84 (41%), Gaps = 9/84 (10%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGR--RSIFSN--GSFIIRTVKAEDSGY 1356
K + L C+ D V W KD P G+ + F + + I K +DSG
Sbjct: 3659 KKVHLECQVDEDRKVTVTWSKDGQKLPP-----GKDYKICFEDKIATLEIPLAKLKDSGT 3713
Query: 1357 YSCIANNNWGSDEIILNLQVQVPP 1380
Y C A+N GS + V+ PP
Sbjct: 3714 YVCTASNEAGSSSCSATVTVREPP 3737
Score = 33.5 bits (75), Expect = 2.2
Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 6/70 (8%)
Query: 236 AMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGR--FQKTVTGLLI---ENIRPSDSGS 290
A AG +++ LG P+P W K + L+ + R F+ T T ++ E +R SDSG
Sbjct: 21077 AKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVR-SDSGP 21135
Query: 291 YVCEVSNRYG 300
Y N G
Sbjct: 21136 YPLTARNIVG 21145
Score = 33.1 bits (74), Expect = 2.8
Identities = 44/197 (22%), Positives = 71/197 (36%), Gaps = 20/197 (10%)
Query: 1307 CKAVGDPSPAVKWMKDSN-----GTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
C G + W KD+ G + ++ + + + V D+G Y+C A
Sbjct: 7233 CHVTGTAPIKITWAKDNREIRPGGNYKMTLVE------NTATLTVLKVGKGDAGQYTCYA 7286
Query: 1362 NNNWGSDEIILNLQVQVPPD-QPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDN 1420
+N G D L VQ PP +L S+ + G I+ +L Y ++
Sbjct: 7287 SNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIK--VLWYKDET 7344
Query: 1421 SEQWGS-FPIS--PSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQF 1477
Q S F +S S + NL +T A N G S ++ K + P F
Sbjct: 7345 EIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVK---EPPIF 7401
Query: 1478 SKEQELFASINTTRVRL 1494
K+ ++ V L
Sbjct: 7402 RKKPHPIETLKGADVHL 7418
Score = 33.1 bits (74), Expect = 2.8
Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 14/127 (11%)
Query: 561 LSDVQKEVDEG-----EYTCNVLVQPQLSTSQ----SVHVTVKVPPFIQPFEFPRFSI-- 609
+ D++ +V+EG EY V + S+ S +V K P + I
Sbjct: 14339 IKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIV 14398
Query: 610 --GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNY 667
G+++ IP + +P T++W KDG+ + S +T+ N ++ L + G Y
Sbjct: 14399 IEGEKLSIPVPFRAVPVP-TVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIY 14457
Query: 668 TCIARNE 674
T N+
Sbjct: 14458 TITLENK 14464
Score = 33.1 bits (74), Expect = 2.8
Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 4/65 (6%)
Query: 844 EEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEI----EIKDVKAR 899
E+ ++ L + + D G + C +N YGED +L V+ + + +K +K R
Sbjct: 31620 EDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRR 31679
Query: 900 TITLR 904
T T+R
Sbjct: 31680 TDTMR 31684
Score = 32.7 bits (73), Expect = 3.7
Identities = 20/69 (28%), Positives = 28/69 (40%), Gaps = 2/69 (2%)
Query: 238 AGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKT--VTGLLIENIRPSDSGSYVCEV 295
AG + L G P P W K + L L T + L +EN +D+G Y V
Sbjct: 28371 AGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTLTV 28430
Query: 296 SNRYGTAKV 304
N G+ +
Sbjct: 28431 ENNSGSKSI 28439
Score = 32.3 bits (72), Expect = 4.8
Identities = 28/100 (28%), Positives = 39/100 (39%), Gaps = 13/100 (13%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIF---SNGSFIIRTVKAEDSGYYSCIANN 1363
C G V W KDS S G+ I ++ + V DSG Y+C A N
Sbjct: 8174 CHVTGTQPIKVSWAKDSREIRS----GGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVN 8229
Query: 1364 NWGSDEIILNLQVQ---VPPDQPRL---TVSKTTSSSITL 1397
G D L ++ +PP + TV +T +S L
Sbjct: 8230 EVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKL 8269
Score = 32.3 bits (72), Expect = 4.8
Identities = 72/356 (20%), Positives = 131/356 (36%), Gaps = 53/356 (14%)
Query: 390 DKLSAQDYVQVVLEDGTPKIISAFSEKVV-SPAEPVSLMCNVKGTPLPTITWTLDDDPIL 448
+K A Y+ + LE+ K KV+ +P PV++ +TW + PI+
Sbjct: 19757 NKYDAGKYI-LTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTW---EPPII 19812
Query: 449 KGGSHRISQMI-------------TSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLY 495
GGS I+ ++ T+E + S+ +++ + +R A N G+
Sbjct: 19813 DGGSPIINYVVQKRDAERKSWSTVTTECSKTSF-RVANLEEGKSYFFRVFAENEYGI--- 19868
Query: 496 QARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYK-----NSNLLPFNHRQ 550
P R + G + R + SI W K S ++ +
Sbjct: 19869 ------GDPGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDF 19922
Query: 551 VAFENNG-----TLKLSDVQKEVDEG-EYTCNVLVQPQLSTSQSVHVTVK-----VPPFI 599
+ EN +L L K++ EG EYT V + + +TV V P +
Sbjct: 19923 LTEENKWQRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDL 19982
Query: 600 QPFEFP------RFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSS 653
P + + R+ IP + G +++W+K P+ V++++ ++
Sbjct: 19983 DLKGLPDLCYLAKENSNFRLKIP---IKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTT 20039
Query: 654 LRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVIL 709
L + + G YT +N A E + V P P D + +A+ L
Sbjct: 20040 LIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTL 20095
Score = 32.3 bits (72), Expect = 4.8
Identities = 23/77 (29%), Positives = 34/77 (44%), Gaps = 12/77 (15%)
Query: 241 RVELPCKALGHPEPDYRWLKDNMPLELSGRFQ----KTVTGLLIENIRPSDSGSYVCEVS 296
R+++P K G P P W K PL R T L++ + + SD+G Y +
Sbjct: 20001 RLKIPIK--GKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLK 20058
Query: 297 NRYGT------AKVIGR 307
N GT KV+G+
Sbjct: 20059 NVAGTKEGTISIKVVGK 20075
Score = 32.3 bits (72), Expect = 4.8
Identities = 34/150 (22%), Positives = 59/150 (39%), Gaps = 19/150 (12%)
Query: 162 KDTVSLVSGSRFLIT--STGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSD 219
K ++ + G+ + I+ +TGA Y+ V++ + + G + S+S+ ++
Sbjct: 26131 KTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKV------------GASDPSDSSDPQIAK 26178
Query: 220 PANSAPSILDGFDHRKAM---AGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV- 275
P + RK + AG + G P P+ W K + L T
Sbjct: 26179 EREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDS 26238
Query: 276 -TGLLIENIRPSDSGSYVCEVSNRYGTAKV 304
T L IEN +DSG Y + N A +
Sbjct: 26239 RTSLTIENANRNDSGKYTLTIQNVLSAASL 26268
Score = 32.0 bits (71), Expect = 6.3
Identities = 33/144 (22%), Positives = 58/144 (40%), Gaps = 15/144 (10%)
Query: 1449 FTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGW----NDGGC 1504
+T+TA N +G S+ + LG+ P F S++ ++ L+ W +DGG
Sbjct: 16194 YTITAVNNLGTA--SKEMRLNVLGR-PGPPVGPIKFESVSADQMTLS---WFPPKDDGGS 16247
Query: 1505 PITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGC-----AEK 1559
IT++ +E R W +Y + L E Y ++ N G +E
Sbjct: 16248 KITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEP 16307
Query: 1560 QANFATLNYDGSTIPPLIKSVVQN 1583
+ + G+ P + SV +N
Sbjct: 16308 ETARNLFSVPGAPDKPTVSSVTRN 16331
Score = 32.0 bits (71), Expect = 6.3
Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 9/76 (11%)
Query: 417 VVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV-SYLNISSSQ 475
VV + ++ V G P PT+TW +++ + Q T E + S + I + Q
Sbjct: 16535 VVHAGGVIRIIAYVSGKPPPTVTWNMNE--------RTLPQEATIETTAISSSMVIKNCQ 16586
Query: 476 VRDGGVYRCTANNSAG 491
GVY A N AG
Sbjct: 16587 RSHQGVYSLLAKNEAG 16602
Score = 32.0 bits (71), Expect = 6.3
Identities = 35/134 (26%), Positives = 50/134 (37%), Gaps = 18/134 (13%)
Query: 189 EDGLYNYRCITRHRYTGETRQSNSARLFVSDP----ANSAPSILDGFDHRKAM----AGQ 240
E Y +R I R T + S SDP A + P +D K++ AG
Sbjct: 19258 EKAQYQFRAIAR------TAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGT 19311
Query: 241 RVELPCKALGHPEPDYRWLKDNMPLE----LSGRFQKTVTGLLIENIRPSDSGSYVCEVS 296
V L G P P W KD L+ + Q+ + L + ++ DSG Y
Sbjct: 19312 NVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAE 19371
Query: 297 NRYGTAKVIGRLYV 310
N G+ +L V
Sbjct: 19372 NSSGSKSATIKLKV 19385
Score = 31.6 bits (70), Expect = 8.2
Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 5/70 (7%)
Query: 1310 VGDPSPAVKWMKDSNGTPSLVTIDGRRSI--FSNGSFIIRTVKAEDSGYYSCIANNNWGS 1367
+GDP+ V+W+ D G P L + R I F S + DSG +C A N +G+
Sbjct: 1729 IGDPTMVVEWLHD--GKP-LEAANRLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGT 1785
Query: 1368 DEIILNLQVQ 1377
D L V+
Sbjct: 1786 DHTSATLIVK 1795
Score = 31.6 bits (70), Expect = 8.2
Identities = 21/77 (27%), Positives = 33/77 (42%), Gaps = 3/77 (3%)
Query: 237 MAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV---TGLLIENIRPSDSGSYVC 293
MAG+ + +P G P P W K+ L+ V + L+I++ D G YV
Sbjct: 15117 MAGKTLRIPAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVI 15176
Query: 294 EVSNRYGTAKVIGRLYV 310
+N G+ R+ V
Sbjct: 15177 TATNSCGSKFAAARVEV 15193
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 247 bits (630), Expect = 1e-64
Identities = 255/1033 (24%), Positives = 423/1033 (40%), Gaps = 122/1033 (11%)
Query: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNS---NLLPFNHRQVAFENNGTLKLSDV----QKE 567
++ G ++C P I+W K+ NL+ + RQ+ +G+L +S+V +
Sbjct: 64 SVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLL--PDGSLFISNVVHSKHNK 121
Query: 568 VDEGEYTCNVLVQP--QLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLP 625
DEG Y C V+ + + + + +P F E G + C V + DL
Sbjct: 122 PDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEV-NADLV 180
Query: 626 ITITWQKDGRPIPGSLGVTIDNIDFTSS--LRISNLSLMHNGNYTCIARNEAAAVEHQSQ 683
+ W+++ +P+ + D + S L ISN + G Y C+ + ++ +
Sbjct: 181 PFVRWEQNRQPL-----LLDDRVIKLPSGMLVISNATEGDGGLYRCVVES-GGPPKYSDE 234
Query: 684 LIVRVPPK--------FVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQ 735
+ ++V P F+ QP + G+ V+L C A G P PTI W ++ A
Sbjct: 235 VELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEA-----L 289
Query: 736 PIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPN 795
+ R+ +L+ GSL I V E+D+G Y C ++++ + LTV+ P
Sbjct: 290 DTESSERLVLLAGGSLEISDVTEDDAGTYFC-IADNGNETIEAQAELTVQAQPEFLKQPT 348
Query: 796 TTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPT 855
A + C G+ V+W K ++ P + Y KE LQ+L
Sbjct: 349 NIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIP--SDYFKIVKE------HNLQVLGL 400
Query: 856 VREDSGFFSCHAINSYGEDRGIIQLTVQE---------PPDPPEIEIKDVKARTITLRW- 905
V+ D GF+ C A N G + QL + E P P ++ V R I L W
Sbjct: 401 VKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWR 460
Query: 906 TMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNR 965
T D + Y + + + + + T P TI ++ P++ Y R+ A+N+
Sbjct: 461 TPASDPHGDNLTYSVFYTKEGIARERVENTSH--PGEMQVTIQNLMPATVYIFRVMAQNK 518
Query: 966 IGKSEPSNELTI-TADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGY 1024
G E S L + T E GP + S SI VTW+ P NG I+ Y++ Y
Sbjct: 519 HGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSG--NGEIQNYKLYY 576
Query: 1025 REYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTL 1084
E T VD S S YT++ L K+T+Y V A N+ G G S+ ++ TL
Sbjct: 577 MEKGTDKEQD-----VDVSSHS--YTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTL 629
Query: 1085 EDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNIT 1144
DVPS P+N+ + +SI I W + NG + G+++ Y ++ E ++
Sbjct: 630 SDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETL-VS 688
Query: 1145 TTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKED------VPGPPAGVKAA 1198
TQ S ++GL++ T Y+ +V A T G G ++ + T E VP P+ +
Sbjct: 689 GTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVR 748
Query: 1199 AASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYS 1258
S+V VSW PP N ++R Y + P + Y I NL + Y
Sbjct: 749 PLVTSIV-VSWTPPENQNIVVRGYAIGYGIGSPHA-QTIKVDYKQRYYTIENLDPSSHYV 806
Query: 1259 VWVVAVTSAGRG-------------NSSEI---ITVEPLAKAP------------ARILT 1290
+ + A + G G ++SE+ + P P A IL+
Sbjct: 807 ITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILS 866
Query: 1291 FSGTVTTPWMKDIVLPCKAVGDPS----------PAVKWMKDSNGTPSLVTIDGRRSIFS 1340
T+ W + + + + D PA K++N T + G + +
Sbjct: 867 HD-TIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKP-NT 924
Query: 1341 NGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWL 1400
F + K S +S A+ L PP + + +I ++W
Sbjct: 925 LYEFSVMVTKGRRSSTWSMTAHGT------TFELVPTSPPKDVTVVSKEGKPKTIIVNWQ 978
Query: 1401 PGDNGGSSIRGYILQYSED-NSE--QWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGV 1457
P I GYI+ YS D N+E W P+ + +++++ L T Y F + A+N
Sbjct: 979 PPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSK 1038
Query: 1458 GPGRISEIIEAKT 1470
G G +SE ++ +T
Sbjct: 1039 GMGPMSEAVQFRT 1051
Score = 154 bits (390), Expect = 6e-37
Identities = 242/1056 (22%), Positives = 388/1056 (36%), Gaps = 152/1056 (14%)
Query: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIM 372
P + P S GS V L+CS ++ W ++G LN + R + +L +
Sbjct: 52 PFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFI 111
Query: 373 DHMV-----KSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVS-- 425
++V K D G YQC + L + T K+I A + S EP S
Sbjct: 112 SNVVHSKHNKPDEGYYQCVATVESLG-------TIISRTAKLIVAGLPRFTSQPEPSSVY 164
Query: 426 ------LMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
L C V +P + W + P+L R+ ++ + L IS++ DG
Sbjct: 165 AGNNAILNCEVNADLVPFVRWEQNRQPLLL--DDRVIKLPS------GMLVISNATEGDG 216
Query: 480 GVYRCTANNSAGVVLYQARINVR---GPASIRPM------KNITAIAGRDTYIHCRVIGY 530
G+YRC S G Y + ++ P I + + + G+D + C G
Sbjct: 217 GLYRCVV-ESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGL 275
Query: 531 PYYSIKWYKNSNLLPF-NHRQVAFENNGTLKLSDVQKEVDEGEYTC-----NVLVQPQLS 584
P +IKW KN L + ++ G+L++SDV ++ D G Y C N ++ Q
Sbjct: 276 PTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTED-DAGTYFCIADNGNETIEAQAE 334
Query: 585 -TSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGV 643
T Q+ +K P I E + C V P T+ W K+G + S
Sbjct: 335 LTVQAQPEFLKQPTNIYAHE------SMDIVFECEVTGKPTP-TVKWVKNGDMVIPS--- 384
Query: 644 TIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV--RVPPKFVVQPRDQDG 701
I +L++ L G Y CIA N+ + +QLI+ P P
Sbjct: 385 DYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRD 444
Query: 702 IYGKAVILN----------CSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSL 751
+ V G + V+ +G + + + G +QV
Sbjct: 445 VVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQV------ 498
Query: 752 LIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTA 811
I++++ + N G+ S + P + + P L G + A
Sbjct: 499 TIQNLMPATVYIFRVMAQNKHGSGESSA-------PLRVETQPEVQL--PGPAPNLRAYA 549
Query: 812 HGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-------FS 864
I V WE N E+ Y + E G + + + +G F
Sbjct: 550 ASPTSITVTWETPVS-GNGEIQNYKLYYMEKGTDKEQDVDVSSHSYTINGLKKYTEYSFR 608
Query: 865 CHAINSYGEDRGIIQLTVQEPPDPP-------EIEIKDVKARTITLRWTMGFDGNSPITG 917
A N +G + V+ D P +E+++ K+ I + N ITG
Sbjct: 609 VVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNGQITG 668
Query: 918 YDIECKNKSDSWDSAQRTKDVSPQLNSAT-----IIDIHPSSTYSIRMYAKNRIGKSEPS 972
Y I + A R DV+ L S T I + + Y+ R+ A G +
Sbjct: 669 YKIR-------YRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPAT 721
Query: 973 NELTITA-----DEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREY 1027
+ L+ DE P +H+ P+ + SI V+W P+ QN ++RGY IGY
Sbjct: 722 DWLSAETFESDLDETRVPEVPSSLHVRPLVT-SIVVSWTPPEN--QNIVVRGYAIGYGI- 777
Query: 1028 STGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLED 1086
G+ I VD YT++NL+ + Y + ++A N G G P + +T D
Sbjct: 778 ---GSPHAQTIKVDYK--QRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTD 832
Query: 1087 -------------------VPSYPPENVQAIATSPESISISWSTLSKEALNGILQG-FRV 1126
P PP VQA S ++I I+W+ S I +
Sbjct: 833 TSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYT 892
Query: 1127 IYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKE 1186
+ W + + KN T S + GL+ T Y V+ S T E
Sbjct: 893 VRWKTNIPANT-KYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFE 951
Query: 1187 DVP-GPPAGVKAAA--ASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASP-- 1241
VP PP V + + V+W PP + NG I Y ++ S I ++ P
Sbjct: 952 LVPTSPPKDVTVVSKEGKPKTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVV 1011
Query: 1242 -DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEII 1276
+ +++I L+ + Y + A S G G SE +
Sbjct: 1012 GNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAV 1047
Score = 133 bits (335), Expect = 2e-30
Identities = 242/1062 (22%), Positives = 410/1062 (38%), Gaps = 187/1062 (17%)
Query: 236 AMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVT---GLLIENIRPS-----D 287
++ G V L C A P P W KD L L ++ + L I N+ S D
Sbjct: 64 SVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPD 123
Query: 288 SGSYVCEVSNRYGTAKVIGR---LYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQE 344
G Y C V+ +I R L V + T P G+ L+C V
Sbjct: 124 EGYYQC-VATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPF 182
Query: 345 LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKD---KLSAQDYVQVV 401
+ W +N + L + R+ + L++ + + DGG Y+C V K S + ++V+
Sbjct: 183 VRWEQNRQPLL--LDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVL 240
Query: 402 LEDGTPKIISAF------SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRI 455
+ P++IS S V + V L C G P PTI W +++ + S R+
Sbjct: 241 PD---PEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERL 297
Query: 456 SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNIT 514
++ + G+ L IS D G Y C A+N + QA + V+ P ++ NI
Sbjct: 298 --VLLAGGS----LEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIY 351
Query: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNSNL-LPFNHRQVAFENNGTLKLSDVQKEVDEGEY 573
A D C V G P ++KW KN ++ +P ++ ++ E+N L++ + K DEG Y
Sbjct: 352 AHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN--LQVLGLVKS-DEGFY 408
Query: 574 TCNVLVQPQLSTSQS---VHVTVKVPPFIQPF-EFPRFSIGQRV---FI------PCVVV 620
C + + + +Q+ + + P P PR + V FI P
Sbjct: 409 QC--IAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDP 466
Query: 621 SGD-LPITITWQKDG--------RPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIA 671
GD L ++ + K+G PG + VTI N+ +++ I + +A
Sbjct: 467 HGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNL-MPATVYI----------FRVMA 515
Query: 672 RNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGV 731
+N+ + E + L V P+ VQ + G A L A T+ W+
Sbjct: 516 QNKHGSGESSAPLRVETQPE--VQ------LPGPAPNLRAYAASPTSITVTWE------- 560
Query: 732 PQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCK-VSNDVGADVSKSMYLTVKIPAMI 790
P++ NG IQ N L YY+ K + DVS Y T+
Sbjct: 561 ---TPVSGNGEIQ---NYKL-----------YYMEKGTDKEQDVDVSSHSY-TINGLKKY 602
Query: 791 TSY----------------PNTTLAT-----QGQKKEMSCTAHGEKPIIVRWE-----KE 824
T Y P+ + T + +S K I++ W+ +
Sbjct: 603 TEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQ 662
Query: 825 DRIINPEMARYLVSTK--EVGEEVISTLQILPTV----REDSGFFSCHAINSYGEDRGII 878
+ I RY +++ +V E ++S Q+ + R F A+ G
Sbjct: 663 NGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATD 722
Query: 879 QLTVQE----------PPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDS 928
L+ + P P + ++ + +I + WT + N + GY I S
Sbjct: 723 WLSAETFESDLDETRVPEVPSSLHVRPL-VTSIVVSWTPPENQNIVVRGYAIGYGIGSPH 781
Query: 929 WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTIT---------- 978
+T V + TI ++ PSS Y I + A N +G+ P E +T
Sbjct: 782 ----AQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVD 837
Query: 979 ----------ADEAAPDGPPQEVHLEPISSQSIRVTW--KAPKKHLQNGIIRGYQIGYRE 1026
+ P PP V +S +IR+TW + KH + R Y + ++
Sbjct: 838 LFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKT 897
Query: 1027 YSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLED 1086
N N + + + Y + L T Y V + S TT E
Sbjct: 898 -----NIPANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFEL 952
Query: 1087 VPSYPPENVQAIAT--SPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGE--IKN 1142
VP+ PP++V ++ P++I ++W S+ NG + G+ +IY++ ++ E+ + I+
Sbjct: 953 VPTSPPKDVTVVSKEGKPKTIIVNWQPPSE--ANGKITGY-IIYYSTDVNAEIHDWVIEP 1009
Query: 1143 ITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRT 1184
+ + + ++ L T Y ++ A G G SE + RT
Sbjct: 1010 VVGNRLTHQIQELTLDTPYYFKIQARNSKGMGPMSEAVQFRT 1051
Score = 130 bits (328), Expect = 1e-29
Identities = 202/847 (23%), Positives = 325/847 (38%), Gaps = 119/847 (14%)
Query: 671 ARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAG 730
AR+ +A + + P F+V+P D + G +VILNCSA P P I WK
Sbjct: 34 ARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKD---- 89
Query: 731 VPQFQPIALNGRIQVLSNGSLLIKHVV-----EEDSGYYLCKVS-NDVGADVSKSMYLTV 784
F + + R Q+L +GSL I +VV + D GYY C + +G +S++ L V
Sbjct: 90 -GTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV 148
Query: 785 KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK-------EDRIINPEMARYLV 837
TS P + G ++C + + VRWE+ +DR+I ++
Sbjct: 149 AGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVI 208
Query: 838 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVK 897
S G D G + C + S G + ++ ++ PDP I
Sbjct: 209 SNATEG---------------DGGLYRC-VVESGGPPKYSDEVELKVLPDPEVISDLVFL 252
Query: 898 ARTITLRWTMGFDGNSPITGY-----DIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHP 952
+ L +G D P I+ ++ D+ + V S I D+
Sbjct: 253 KQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTE 312
Query: 953 SSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSI----RVTWKAP 1008
+ A N E ELT+ +A P+ Q ++ S I VT K
Sbjct: 313 DDAGTYFCIADNGNETIEAQAELTV---QAQPEFLKQPTNIYAHESMDIVFECEVTGKPT 369
Query: 1009 K--KHLQNGIIRGYQIGYREYSTGGNFQ-FNIISVDTSGDSEVYTLDNLNKFTQYGLVVQ 1065
K ++NG + Y + N Q ++ D + D N L++
Sbjct: 370 PTVKWVKNGDM-VIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIIL 428
Query: 1066 ACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFR 1125
A TGP +PS P +V A S I ++W T + + +G +
Sbjct: 429 EHAPATTGP------------LPS-APRDVVASLVSTRFIKLTWRTPASDP-HGDNLTYS 474
Query: 1126 VIYWANLMDGELGEIKNITTTQP---SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFT 1182
V Y + E E T+ P + + L T Y +V+A + G G S +
Sbjct: 475 VFYTKEGIARERVE----NTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV 530
Query: 1183 RTKEDV--PGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEAS 1240
T+ +V PGP ++A AAS + + V+W P+ NG I+ Y ++ + E +
Sbjct: 531 ETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLY--YMEKGTDKEQDVD 588
Query: 1241 PDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARI-------LTFSG 1293
S SY I L + +YS VVA G G S+ + V L+ P+ + S
Sbjct: 589 VSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSK 648
Query: 1294 TVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS--------IFSNGSFI 1345
++ W P+PA + NG + I R++ +G+ +
Sbjct: 649 SIMIHWQ-----------PPAPATQ-----NGQITGYKIRYRKASRKSDVTETLVSGTQL 692
Query: 1346 IRTVKAEDSG--YYSCIA---------NNNWGSDEII-LNLQVQVPPDQPRLTVSKTTSS 1393
+ ++ D G Y +A +W S E +L P+ P + +
Sbjct: 693 SQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVT 752
Query: 1394 SITLSWLPGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTA 1453
SI +SW P +N +RGY + Y S + + +R Y +ENL + Y TL A
Sbjct: 753 SIVVSWTPPENQNIVVRGYAIGYG-IGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKA 811
Query: 1454 QNGVGPG 1460
N VG G
Sbjct: 812 FNNVGEG 818
Score = 105 bits (262), Expect = 4e-22
Identities = 103/400 (25%), Positives = 161/400 (40%), Gaps = 38/400 (9%)
Query: 82 QIFPFPPSSFSTLIH------DNTYY-CTAENPS-GKIRSQDVHIKAVLREPYTVRVEDQ 133
Q+ P S ++H D YY C A S G I S+ + +T + E
Sbjct: 102 QLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS 161
Query: 134 KTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLY 193
GN A+ C + + + + V WE++ L+ R + +G L I + DG
Sbjct: 162 SVYAGNNAILNCEVNADL---VPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGL 218
Query: 194 NYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKA------MAGQRVELPCK 247
YRC+ G + S+ L V P ++ K + GQ V LPC
Sbjct: 219 -YRCVVESG--GPPKYSDEVELKVLPD----PEVISDLVFLKQPSPLVRVIGQDVVLPCV 271
Query: 248 ALGHPEPDYRWLKDNMPL--ELSGRFQKTVTGLL-IENIRPSDSGSYVCEVSNRYGTAKV 304
A G P P +W+K+ L E S R G L I ++ D+G+Y C N T +
Sbjct: 272 ASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEA 331
Query: 305 IGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITG 364
L V+ + P + + + C VTG + W +NG+++ P +I
Sbjct: 332 QAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKI-- 389
Query: 365 INHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPV 424
+ NL + +VKSD G YQC D +AQ Q+++ + P P+ P
Sbjct: 390 VKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPL------PSAPR 443
Query: 425 SLMCNVKGTPLPTITW-TLDDDPILKGGSHRISQMITSEG 463
++ ++ T +TW T DP G + S T EG
Sbjct: 444 DVVASLVSTRFIKLTWRTPASDP--HGDNLTYSVFYTKEG 481
Score = 63.9 bits (154), Expect = 1e-09
Identities = 79/335 (23%), Positives = 132/335 (39%), Gaps = 20/335 (5%)
Query: 1267 AGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGT 1326
A GN + E +A L + DIV C+ G P+P VKW+K+ +
Sbjct: 322 ADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGD-- 379
Query: 1327 PSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV--QVP----- 1379
++ D + + + ++ VK+ D G+Y CIA N+ G+ + L + P
Sbjct: 380 -MVIPSDYFKIVKEHNLQVLGLVKS-DEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
Query: 1380 -PDQPRLTVSKTTSSS-ITLSWL--PGDNGGSSIRGYILQYSEDNSEQWGSFPISPSERS 1435
P PR V+ S+ I L+W D G ++ + E + + P E
Sbjct: 438 LPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQ 497
Query: 1436 YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFA-SINTTRVRL 1494
++NL T Y F + AQN G G S + +T + L A + + T + +
Sbjct: 498 VTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITV 557
Query: 1495 NLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSA 1554
G I ++ L Y GT + S SY + L++ T Y ++ N
Sbjct: 558 TWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVS--SHSYTINGLKKYTEYSFRVVAYNKH 615
Query: 1555 GCAEKQANFA--TLNYDGSTIPPLIKSVVQNEEGL 1587
G + A TL+ S P + V+N + +
Sbjct: 616 GPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKSI 650
Score = 48.5 bits (114), Expect = 6e-05
Identities = 88/431 (20%), Positives = 161/431 (37%), Gaps = 32/431 (7%)
Query: 1149 SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFT-----RTKEDVPGPPAGVKAAAASAS 1203
+L++ GL K Q +A G+ Q+ T +P P V A+ S
Sbjct: 394 NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGPLPSAPRDVVASLVSTR 453
Query: 1204 MVFVSWLPPLK-LNGIIRKYTVFCSHP-YPTVISEFEASPDSFSYRIPNLSRNRQYSVWV 1261
+ ++W P +G Y+VF + E + P I NL Y V
Sbjct: 454 FIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRV 513
Query: 1262 VAVTSAGRGNSSEIITVE--PLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPS-PAVK 1318
+A G G SS + VE P + P +P + G+ K
Sbjct: 514 MAQNKHGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYK 573
Query: 1319 WMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG----SDEIILNL 1374
GT +D S+ S+ I +K + +A N G + ++ +
Sbjct: 574 LYYMEKGTDKEQDVD-----VSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRT 628
Query: 1375 QVQVPPDQPR-LTVSKTTSSSITLSWLPG----DNGGSSIRGYILQYSE-DNSEQWGSFP 1428
VP P+ L++ S SI + W P NG I GY ++Y +
Sbjct: 629 LSDVPSAAPQNLSLEVRNSKSIMIHWQPPAPATQNG--QITGYKIRYRKASRKSDVTETL 686
Query: 1429 ISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASIN 1488
+S ++ S +E L GT Y F + A G G ++ + A+T + ++ E+ +S++
Sbjct: 687 VSGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLSAETFESDLDETRVPEVPSSLH 746
Query: 1489 TTRVRLNL-IGW---NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWY 1544
+ ++ + W + + + + Y G+ T + + Y + +L ++ Y
Sbjct: 747 VRPLVTSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQRYYTIENLDPSSHY 805
Query: 1545 ELQMRVCNSAG 1555
+ ++ N+ G
Sbjct: 806 VITLKAFNNVG 816
Score = 37.7 bits (86), Expect = 0.11
Identities = 43/190 (22%), Positives = 80/190 (42%), Gaps = 26/190 (13%)
Query: 43 LVPCPAAGIPPVTLRWYLATGEEIYDVPGIRH--VHPNGTLQIFPFPPSSFSTLIHDNTY 100
++PC A+G+P T++W EE D + G+L+I S T TY
Sbjct: 267 VLPCVASGLPTPTIKW--MKNEEALDTESSERLVLLAGGSLEI------SDVTEDDAGTY 318
Query: 101 YCTAENPSGKIRSQ-DVHIKA---VLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYIT 156
+C A+N + I +Q ++ ++A L++P + + + VF+C +
Sbjct: 319 FCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDI-----VFECEVTGKP---TP 370
Query: 157 VVSWEKDTVSLVSGSRFLITSTGALYIKD-VQNEDGLYNYRCITRHRYTGETRQSNSARL 215
V W K+ ++ F I L + V++++G Y+CI + G + +
Sbjct: 371 TVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGF--YQCIAEND-VGNAQAGAQLII 427
Query: 216 FVSDPANSAP 225
PA + P
Sbjct: 428 LEHAPATTGP 437
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 243 bits (621), Expect = 1e-63
Identities = 251/1016 (24%), Positives = 429/1016 (42%), Gaps = 88/1016 (8%)
Query: 306 GRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGI 365
G ++ P+ SPR++ +SL C +G + + W R+G P + + +T
Sbjct: 28 GHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVY 87
Query: 366 N--HENLIM-----DHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKV- 417
H + + G Y+CF +A + ++ +G PK + V
Sbjct: 88 QSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE 147
Query: 418 VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVR 477
V E V L CN + P + ++ + R++ + GN+ ++S
Sbjct: 148 VEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT--MGQNGNLYFANVLTSDNHS 205
Query: 478 DGGVYRCTAN-NSAGVVLYQARINVRGPAS-------------IRPMKNITAIAGRDTYI 523
D Y C A+ ++ + I++R A+ ++ A+ G+ +
Sbjct: 206 D---YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVL 262
Query: 524 HCRVIGYPYYSIKWYKNSNLLPFNHRQVAFEN-NGTLKLSDVQKEVDEGEYTCNVLVQPQ 582
C G+P +IKW + S +P + +V ++N N TL+L V +E D+GEY C L +
Sbjct: 263 ECIAEGFPTPTIKWLRPSGPMPAD--RVTYQNHNKTLQLLKVGEE-DDGEYRC--LAENS 317
Query: 583 LSTSQ-SVHVTVKVPPF-IQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGS 640
L +++ + +VTV+ P+ + + + G+ + C V P +TW+ +G P+
Sbjct: 318 LGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQP-EVTWRINGIPVEEL 376
Query: 641 LGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPRDQ 699
I +L +SN+ C ARN + + + +V++P K +
Sbjct: 377 AKDQKYRIQ-RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQT 435
Query: 700 D-GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVE 758
+ G L C A G PVP++ W G V Q + R +NG+L I+ +
Sbjct: 436 YMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDE------RFFPYANGTLGIRDLQA 489
Query: 759 EDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPI- 817
D+G Y C +ND +V+ L VK IT P +T+ +G + +C A + +
Sbjct: 490 NDTGRYFCLAANDQN-NVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQ 548
Query: 818 -IVRWEKEDRIINP--EMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGED 874
+ W + R + + +Y + E G VI +L D G +SC A
Sbjct: 549 PSITWRGDGRDLQELGDSDKYFI---EDGRLVIHSLDY-----SDQGNYSCVASTELDVV 600
Query: 875 RGIIQLTVQEPPDP-PEIEIKDVKART---ITLRWTMGFDGNSPITGYDIECKNKS---D 927
QL V P P P + + D+ T + + W+ D N+PI YDIE ++K +
Sbjct: 601 ESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPE 660
Query: 928 SWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN-ELTITADEAAPDG 986
W S + P ++T + + P Y+ R+ A N+ G EPS T+ EAAP+
Sbjct: 661 KWYSLGKV----PGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEK 716
Query: 987 PPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDS 1046
P +V E + ++ +TWK + N Y++ +R T G +Q I+S
Sbjct: 717 NPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVS------D 770
Query: 1047 EVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESIS 1106
+ N + F Y + VQA N G GP Q I + ED P PE + ++
Sbjct: 771 PFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVL 830
Query: 1107 ISWSTLSKEALNGILQGFRVIYWANLMDGELG------EIKNITTTQPSLELDGLEKYTN 1160
+ W + + G L+G+ V YW + + + S+ L GL Y++
Sbjct: 831 VKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSS 890
Query: 1161 YSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIR 1220
Y ++V AF G G SE F+ T E VPG P + S + + + W PPL NG++
Sbjct: 891 YHLEVQAFNGRGSGPASEFTFS-TPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLT 949
Query: 1221 KYTVFCSHPYPT----VISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNS 1272
Y V HP +S P+ ++ + +LS + +Y + A T G G +
Sbjct: 950 GY-VLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEA 1004
Score = 174 bits (442), Expect = 6e-43
Identities = 255/1039 (24%), Positives = 418/1039 (40%), Gaps = 122/1039 (11%)
Query: 242 VELPCKALGHPEPDYRWLKDNMPLE-------------LSGRFQKTVTGLLIENIRPSDS 288
+ L C+A G PE +RW +D + + SG F T+TG N
Sbjct: 53 ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSF--TITG-NNSNFAQRFQ 109
Query: 289 GSYVCEVSNRYGTA-----KVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQ 343
G Y C SN+ GTA +++ K P K T+ P +V+ G V L C+ + +
Sbjct: 110 GIYRCFASNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEE--GESVVLPCNPPPSAEP 166
Query: 344 ELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGA-YQC---------FVRKDKLS 393
++ N +IL+ ++ R+T + NL +++ SD + Y C ++K+ +
Sbjct: 167 LRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPID 226
Query: 394 AQDYVQVVLEDGTPKII---SAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKG 450
+ + D P+++ ++ S V +P+ L C +G P PTI W P+
Sbjct: 227 LRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPM--- 283
Query: 451 GSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR-GPASIRP 509
+ R++ + + L + D G YRC A NS G + + V P +
Sbjct: 284 PADRVTYQ--NHNKTLQLLKVGE---EDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHK 338
Query: 510 MKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFE-NNGTLKLSDVQKEV 568
++ G + C+V G P + W N + + + G L LS+VQ
Sbjct: 339 PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPS- 397
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSI--GQRVFIPCVVVSGDLPI 626
D C + L + + V++P I + + G ++ C +P
Sbjct: 398 DTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPS 457
Query: 627 TITWQKDGRPIPGSLGVTIDNIDF---TSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQ 683
+DG V D F +L I +L G Y C+A N+ V +
Sbjct: 458 VQWLDEDGTT------VLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMAN 511
Query: 684 LIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYP--VPTIVWKFSKGAGVPQFQPIALNG 741
L V+ + PR G V C A P P+I W +G G Q + +
Sbjct: 512 LKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW---RGDG-RDLQELGDSD 567
Query: 742 RIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV----KIPAMITSYPNTT 797
+ + +G L+I + D G Y C S ++ S++ L V +P ++ S +
Sbjct: 568 K-YFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLS--DLH 624
Query: 798 LATQGQKKEMSCTAHGEKPIIVRW--EKEDRIINPEMARYLVSTKEVGEEVISTLQILPT 855
L TQ Q + A I ++ E ED+ + PE ++ K G + +TL++ P
Sbjct: 625 LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPE--KWYSLGKVPGNQTSTTLKLSPY 682
Query: 856 VREDSGFFSCHAINSYGE-DRGIIQLTVQEPPDPPEIEIKDVKAR-------TITLRWTM 907
V F AIN YG + + TV P PE DVK IT +
Sbjct: 683 VHYT---FRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR 739
Query: 908 GFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSST---YSIRMYAKN 964
D N+P Y ++ W Q+ S + + +ST Y I++ A N
Sbjct: 740 WMDWNAPQVQYRVQ-------WRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVN 792
Query: 965 RIGKSEPSNELTI-TADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIG 1023
GK P ++TI + E P P+ +E ++S ++ V W+ G +RGY +
Sbjct: 793 SQGKG-PEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVT 851
Query: 1024 Y-REYSTGGNFQFNIIS--VDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEII 1080
Y RE S + + +I V ++ L L ++ Y L VQA N G+GP+S E
Sbjct: 852 YWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFT 910
Query: 1081 TTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEI 1140
+T E VP + PE + S S+ + W NG+L G+ V+ + L +G G++
Sbjct: 911 FSTPEGVPGH-PEALHLECQSNTSLLLRWQPPLSH--NGVLTGY-VLSYHPLDEGGKGQL 966
Query: 1141 KNITTTQPSL---ELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVK- 1196
+ P L L L + Y Q+ A T+ G G E I +E +G+
Sbjct: 967 -SFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPG---EAI---VREGGTMALSGISD 1019
Query: 1197 ----AAAASASMVFVSWLP 1211
+A A + VSW+P
Sbjct: 1020 FGNISATAGENYSVVSWVP 1038
Score = 99.4 bits (246), Expect = 3e-20
Identities = 138/594 (23%), Positives = 215/594 (36%), Gaps = 49/594 (8%)
Query: 30 SLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTL--QIFPFP 87
S + +V T + C A+G P V RW T + + H P L ++ P
Sbjct: 41 SPRRLVVFPTDDISLKCEASGKPEVQFRW---TRDGV-------HFKPKEELGVTVYQSP 90
Query: 88 PSSFSTLIHDNT---------YYCTAENPSGKIRSQDVHIKAVLREPYTVR-VEDQKTMR 137
S T+ +N+ Y C A N G S ++ + A + V+ +
Sbjct: 91 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 150
Query: 138 GNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRC 197
G V C P S E + + + + R + G LY +V D +Y C
Sbjct: 151 GESVVLPCNPPPSAEP-LRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 209
Query: 198 ITRHRYTGETRQSNSARLFV---SDPANSAPSIL---DGFDHRKAMAGQRVELPCKALGH 251
T Q L V + + P +L + H A+ GQ + L C A G
Sbjct: 210 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 269
Query: 252 PEPDYRWLKDNMPLELSG-RFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYV 310
P P +WL+ + P+ +Q L + + D G Y C N G+A+ + V
Sbjct: 270 PTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTV 329
Query: 311 KQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENL 370
+ P+ G L C V G E++W NG + + I L
Sbjct: 330 EAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGAL 389
Query: 371 IMDHMVKSDGGAYQCFVRK--DKLSAQDYVQVVLEDGTPKIISAFSEKVVS-PAEPVSLM 427
I+ ++ SD QC R L A Y+ VV KI++A ++ ++ L+
Sbjct: 390 ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV--QLPAKILTADNQTYMAVQGSTAYLL 447
Query: 428 CNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTAN 487
C G P+P++ W LD+D R L I Q D G Y C A
Sbjct: 448 CKAFGAPVPSVQW-LDEDGTTVLQDERFFPYANGT------LGIRDLQANDTGRYFCLAA 500
Query: 488 NSAGVVLYQARINVRGPASIR--PMKNITAIAGRDTYIHCRVIGYPYY--SIKWYKNS-N 542
N V A + V+ I P I R T+ C+ P SI W + +
Sbjct: 501 NDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFT-CQASFDPSLQPSITWRGDGRD 559
Query: 543 LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVP 596
L F +G L + + D+G Y+C + + S++ + V P
Sbjct: 560 LQELGDSDKYFIEDGRLVIHSLDYS-DQGNYSCVASTELDVVESRAQLLVVGSP 612
Score = 80.1 bits (196), Expect = 2e-14
Identities = 98/399 (24%), Positives = 157/399 (39%), Gaps = 33/399 (8%)
Query: 19 DLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPN 78
D L F S +V ++ C A G P T++W +G D + + + N
Sbjct: 237 DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPAD--RVTYQNHN 294
Query: 79 GTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTV-RVEDQKTMR 137
TLQ+ D Y C AEN G R + V PY + + +
Sbjct: 295 KTLQLLKVGEED------DGEYRCLAENSLGSARH--AYYVTVEAAPYWLHKPQSHLYGP 346
Query: 138 GNVAVFKCIIPSSVEAYITVVSWEKDTV---SLVSGSRFLITSTGALYIKDVQNEDGLYN 194
G A C + + +T W + + L ++ I GAL + +VQ D +
Sbjct: 347 GETARLDCQVQGRPQPEVT---WRINGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVT 402
Query: 195 YRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMA--GQRVELPCKALGHP 252
+C R+R+ +N+ V PA + D++ MA G L CKA G P
Sbjct: 403 -QCEARNRHG--LLLANAYIYVVQLPAKILTA-----DNQTYMAVQGSTAYLLCKAFGAP 454
Query: 253 EPDYRWL-KDNMPLELSGRFQKTVTGLL-IENIRPSDSGSYVCEVSNRYGTAKVIGRLYV 310
P +WL +D + RF G L I +++ +D+G Y C +N ++ L V
Sbjct: 455 VPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKV 514
Query: 311 KQPLKATISPRKVKSSVGSQVSLSC--SVTGTEDQELSWYRNGEILNPGKNVRITGINHE 368
K + T PR GS+V+ +C S + ++W +G L + I
Sbjct: 515 KDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG 574
Query: 369 NLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTP 407
L++ + SD G Y C V +L + +L G+P
Sbjct: 575 RLVIHSLDYSDQGNYSC-VASTELDVVESRAQLLVVGSP 612
Score = 76.6 bits (187), Expect = 2e-13
Identities = 69/286 (24%), Positives = 113/286 (39%), Gaps = 16/286 (5%)
Query: 1303 IVLPCKAVGDPS--PAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
+ C+A DPS P++ W D L D + +G +I ++ D G YSC+
Sbjct: 535 VTFTCQASFDPSLQPSITWRGDGRDLQELG--DSDKYFIEDGRLVIHSLDYSDQGNYSCV 592
Query: 1361 ANNNWGSDEIILNLQVQVPPDQ-PRLTVSKT---TSSSITLSWLPGDNGGSSIRGYILQY 1416
A+ E L V P PRL +S T S + +SW P ++ + I Y +++
Sbjct: 593 ASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEF 652
Query: 1417 SEDNS--EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474
+ E+W S P ++ L Y F +TA N GPG S + E +
Sbjct: 653 EDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEA 712
Query: 1475 PQFSKEQELFASINTTR---VRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSK 1531
++ N T + + W D P + +++RP GT Q S
Sbjct: 713 APEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVS-DP 771
Query: 1532 SYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLI 1577
++ + YE++++ NS G + T+ Y G P I
Sbjct: 772 FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQ--VTIGYSGEDYPQAI 815
Score = 55.8 bits (133), Expect = 4e-07
Identities = 41/116 (35%), Positives = 61/116 (52%), Gaps = 7/116 (6%)
Query: 1281 LAKAPARILTFSG-TVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIF 1339
+ + PA+ILT T L CKA G P P+V+W+ D +GT L D R +
Sbjct: 421 VVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL-DEDGTTVLQ--DERFFPY 477
Query: 1340 SNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVP---PDQPRLTVSKTTS 1392
+NG+ IR ++A D+G Y C+A N+ + I+ NL+V+ PR T+ K S
Sbjct: 478 ANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGS 533
Score = 43.9 bits (102), Expect = 0.002
Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 8/80 (10%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKA--EDSGYYSCI 1360
+VL C A G P+P +KW++ S P+ R + N + ++ +K ED G Y C+
Sbjct: 260 LVLECIAEGFPTPTIKWLRPSGPMPA------DRVTYQNHNKTLQLLKVGEEDDGEYRCL 313
Query: 1361 ANNNWGSDEIILNLQVQVPP 1380
A N+ GS + V+ P
Sbjct: 314 AENSLGSARHAYYVTVEAAP 333
Score = 40.8 bits (94), Expect = 0.014
Identities = 91/415 (21%), Positives = 149/415 (35%), Gaps = 34/415 (8%)
Query: 1155 LEKYTNYSIQVLAFTRAGDGVRSEQIFTR-TKEDVPGP-PAGVKAAAASASMVFVSWLPP 1212
L Y +Y+ +V A + G G S T T E P P VK + + ++W P
Sbjct: 679 LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPL 738
Query: 1213 --LKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRG 1270
+ N +Y V + + D F + N S Y + V AV S G+G
Sbjct: 739 RWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLV-VSNTSTFVPYEIKVQAVNSQGKG 797
Query: 1271 NSSEIITVEPLAKAPARILTFSG-------TVTTPWMKDIVLPCKAVGDPSPAVKWMKDS 1323
++ P I G V W + K W + S
Sbjct: 798 PEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGS 857
Query: 1324 NGTPSLVTIDGRRSIF--SNGSFIIRTVKAEDSGYYSCIANNNWGS---DEIILNLQVQV 1378
S I + + S I+ ++ S + A N GS E + V
Sbjct: 858 QRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGV 917
Query: 1379 PPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYS--EDNSEQWGSFPI-SPSERS 1435
P L + +++S+ L W P + + GY+L Y ++ + SF + P R+
Sbjct: 918 PGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRT 977
Query: 1436 YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTR-VRL 1494
+ L +L Y+F L A GPG + + E T+ F +I+ T
Sbjct: 978 HNLTDLSPHLRYRFQLQATTKEGPGE-AIVREGGTMALSGISD-----FGNISATAGENY 1031
Query: 1495 NLIGW--NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQ 1547
+++ W +G C F + ++ G SLS Y+ Y+ T ++LQ
Sbjct: 1032 SVVSWVPKEGQCNF-RFHILFKALG----EEKGGASLSPQYVSYNQSSYTQWDLQ 1081
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 243 bits (621), Expect = 1e-63
Identities = 251/1016 (24%), Positives = 429/1016 (42%), Gaps = 88/1016 (8%)
Query: 306 GRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGI 365
G ++ P+ SPR++ +SL C +G + + W R+G P + + +T
Sbjct: 28 GHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVY 87
Query: 366 N--HENLIM-----DHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKV- 417
H + + G Y+CF +A + ++ +G PK + V
Sbjct: 88 QSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVE 147
Query: 418 VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVR 477
V E V L CN + P + ++ + R++ + GN+ ++S
Sbjct: 148 VEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT--MGQNGNLYFANVLTSDNHS 205
Query: 478 DGGVYRCTAN-NSAGVVLYQARINVRGPAS-------------IRPMKNITAIAGRDTYI 523
D Y C A+ ++ + I++R A+ ++ A+ G+ +
Sbjct: 206 D---YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVL 262
Query: 524 HCRVIGYPYYSIKWYKNSNLLPFNHRQVAFEN-NGTLKLSDVQKEVDEGEYTCNVLVQPQ 582
C G+P +IKW + S +P + +V ++N N TL+L V +E D+GEY C L +
Sbjct: 263 ECIAEGFPTPTIKWLRPSGPMPAD--RVTYQNHNKTLQLLKVGEE-DDGEYRC--LAENS 317
Query: 583 LSTSQ-SVHVTVKVPPF-IQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGS 640
L +++ + +VTV+ P+ + + + G+ + C V P +TW+ +G P+
Sbjct: 318 LGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQP-EVTWRINGIPVEEL 376
Query: 641 LGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPRDQ 699
I +L +SN+ C ARN + + + +V++P K +
Sbjct: 377 AKDQKYRIQ-RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQT 435
Query: 700 D-GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVE 758
+ G L C A G PVP++ W G V Q + R +NG+L I+ +
Sbjct: 436 YMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDE------RFFPYANGTLGIRDLQA 489
Query: 759 EDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPI- 817
D+G Y C +ND +V+ L VK IT P +T+ +G + +C A + +
Sbjct: 490 NDTGRYFCLAANDQN-NVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQ 548
Query: 818 -IVRWEKEDRIINP--EMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGED 874
+ W + R + + +Y + E G VI +L D G +SC A
Sbjct: 549 PSITWRGDGRDLQELGDSDKYFI---EDGRLVIHSLDY-----SDQGNYSCVASTELDVV 600
Query: 875 RGIIQLTVQEPPDP-PEIEIKDVKART---ITLRWTMGFDGNSPITGYDIECKNKS---D 927
QL V P P P + + D+ T + + W+ D N+PI YDIE ++K +
Sbjct: 601 ESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPE 660
Query: 928 SWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN-ELTITADEAAPDG 986
W S + P ++T + + P Y+ R+ A N+ G EPS T+ EAAP+
Sbjct: 661 KWYSLGKV----PGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEK 716
Query: 987 PPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDS 1046
P +V E + ++ +TWK + N Y++ +R T G +Q I+S
Sbjct: 717 NPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVS------D 770
Query: 1047 EVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESIS 1106
+ N + F Y + VQA N G GP Q I + ED P PE + ++
Sbjct: 771 PFLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVL 830
Query: 1107 ISWSTLSKEALNGILQGFRVIYWANLMDGELG------EIKNITTTQPSLELDGLEKYTN 1160
+ W + + G L+G+ V YW + + + S+ L GL Y++
Sbjct: 831 VKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSS 890
Query: 1161 YSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIR 1220
Y ++V AF G G SE F+ T E VPG P + S + + + W PPL NG++
Sbjct: 891 YHLEVQAFNGRGSGPASEFTFS-TPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLT 949
Query: 1221 KYTVFCSHPYPT----VISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNS 1272
Y V HP +S P+ ++ + +LS + +Y + A T G G +
Sbjct: 950 GY-VLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEA 1004
Score = 174 bits (442), Expect = 6e-43
Identities = 255/1039 (24%), Positives = 418/1039 (40%), Gaps = 122/1039 (11%)
Query: 242 VELPCKALGHPEPDYRWLKDNMPLE-------------LSGRFQKTVTGLLIENIRPSDS 288
+ L C+A G PE +RW +D + + SG F T+TG N
Sbjct: 53 ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSF--TITG-NNSNFAQRFQ 109
Query: 289 GSYVCEVSNRYGTA-----KVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQ 343
G Y C SN+ GTA +++ K P K T+ P +V+ G V L C+ + +
Sbjct: 110 GIYRCFASNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEE--GESVVLPCNPPPSAEP 166
Query: 344 ELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGA-YQC---------FVRKDKLS 393
++ N +IL+ ++ R+T + NL +++ SD + Y C ++K+ +
Sbjct: 167 LRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPID 226
Query: 394 AQDYVQVVLEDGTPKII---SAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKG 450
+ + D P+++ ++ S V +P+ L C +G P PTI W P+
Sbjct: 227 LRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPM--- 283
Query: 451 GSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR-GPASIRP 509
+ R++ + + L + D G YRC A NS G + + V P +
Sbjct: 284 PADRVTYQ--NHNKTLQLLKVGE---EDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHK 338
Query: 510 MKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFE-NNGTLKLSDVQKEV 568
++ G + C+V G P + W N + + + G L LS+VQ
Sbjct: 339 PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPS- 397
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSI--GQRVFIPCVVVSGDLPI 626
D C + L + + V++P I + + G ++ C +P
Sbjct: 398 DTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPS 457
Query: 627 TITWQKDGRPIPGSLGVTIDNIDF---TSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQ 683
+DG V D F +L I +L G Y C+A N+ V +
Sbjct: 458 VQWLDEDGTT------VLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMAN 511
Query: 684 LIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYP--VPTIVWKFSKGAGVPQFQPIALNG 741
L V+ + PR G V C A P P+I W +G G Q + +
Sbjct: 512 LKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW---RGDG-RDLQELGDSD 567
Query: 742 RIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV----KIPAMITSYPNTT 797
+ + +G L+I + D G Y C S ++ S++ L V +P ++ S +
Sbjct: 568 K-YFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLS--DLH 624
Query: 798 LATQGQKKEMSCTAHGEKPIIVRW--EKEDRIINPEMARYLVSTKEVGEEVISTLQILPT 855
L TQ Q + A I ++ E ED+ + PE ++ K G + +TL++ P
Sbjct: 625 LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPE--KWYSLGKVPGNQTSTTLKLSPY 682
Query: 856 VREDSGFFSCHAINSYGE-DRGIIQLTVQEPPDPPEIEIKDVKAR-------TITLRWTM 907
V F AIN YG + + TV P PE DVK IT +
Sbjct: 683 VHYT---FRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR 739
Query: 908 GFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSST---YSIRMYAKN 964
D N+P Y ++ W Q+ S + + +ST Y I++ A N
Sbjct: 740 WMDWNAPQVQYRVQ-------WRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVN 792
Query: 965 RIGKSEPSNELTI-TADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIG 1023
GK P ++TI + E P P+ +E ++S ++ V W+ G +RGY +
Sbjct: 793 SQGKG-PEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVT 851
Query: 1024 Y-REYSTGGNFQFNIIS--VDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEII 1080
Y RE S + + +I V ++ L L ++ Y L VQA N G+GP+S E
Sbjct: 852 YWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFT 910
Query: 1081 TTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEI 1140
+T E VP + PE + S S+ + W NG+L G+ V+ + L +G G++
Sbjct: 911 FSTPEGVPGH-PEALHLECQSNTSLLLRWQPPLSH--NGVLTGY-VLSYHPLDEGGKGQL 966
Query: 1141 KNITTTQPSL---ELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVK- 1196
+ P L L L + Y Q+ A T+ G G E I +E +G+
Sbjct: 967 -SFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPG---EAI---VREGGTMALSGISD 1019
Query: 1197 ----AAAASASMVFVSWLP 1211
+A A + VSW+P
Sbjct: 1020 FGNISATAGENYSVVSWVP 1038
Score = 99.4 bits (246), Expect = 3e-20
Identities = 138/594 (23%), Positives = 215/594 (36%), Gaps = 49/594 (8%)
Query: 30 SLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTL--QIFPFP 87
S + +V T + C A+G P V RW T + + H P L ++ P
Sbjct: 41 SPRRLVVFPTDDISLKCEASGKPEVQFRW---TRDGV-------HFKPKEELGVTVYQSP 90
Query: 88 PSSFSTLIHDNT---------YYCTAENPSGKIRSQDVHIKAVLREPYTVR-VEDQKTMR 137
S T+ +N+ Y C A N G S ++ + A + V+ +
Sbjct: 91 HSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEE 150
Query: 138 GNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRC 197
G V C P S E + + + + R + G LY +V D +Y C
Sbjct: 151 GESVVLPCNPPPSAEP-LRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYIC 209
Query: 198 ITRHRYTGETRQSNSARLFV---SDPANSAPSIL---DGFDHRKAMAGQRVELPCKALGH 251
T Q L V + + P +L + H A+ GQ + L C A G
Sbjct: 210 HAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGF 269
Query: 252 PEPDYRWLKDNMPLELSG-RFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYV 310
P P +WL+ + P+ +Q L + + D G Y C N G+A+ + V
Sbjct: 270 PTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTV 329
Query: 311 KQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENL 370
+ P+ G L C V G E++W NG + + I L
Sbjct: 330 EAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGAL 389
Query: 371 IMDHMVKSDGGAYQCFVRK--DKLSAQDYVQVVLEDGTPKIISAFSEKVVS-PAEPVSLM 427
I+ ++ SD QC R L A Y+ VV KI++A ++ ++ L+
Sbjct: 390 ILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV--QLPAKILTADNQTYMAVQGSTAYLL 447
Query: 428 CNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTAN 487
C G P+P++ W LD+D R L I Q D G Y C A
Sbjct: 448 CKAFGAPVPSVQW-LDEDGTTVLQDERFFPYANGT------LGIRDLQANDTGRYFCLAA 500
Query: 488 NSAGVVLYQARINVRGPASIR--PMKNITAIAGRDTYIHCRVIGYPYY--SIKWYKNS-N 542
N V A + V+ I P I R T+ C+ P SI W + +
Sbjct: 501 NDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFT-CQASFDPSLQPSITWRGDGRD 559
Query: 543 LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVP 596
L F +G L + + D+G Y+C + + S++ + V P
Sbjct: 560 LQELGDSDKYFIEDGRLVIHSLDYS-DQGNYSCVASTELDVVESRAQLLVVGSP 612
Score = 80.1 bits (196), Expect = 2e-14
Identities = 98/399 (24%), Positives = 157/399 (39%), Gaps = 33/399 (8%)
Query: 19 DLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPN 78
D L F S +V ++ C A G P T++W +G D + + + N
Sbjct: 237 DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPAD--RVTYQNHN 294
Query: 79 GTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTV-RVEDQKTMR 137
TLQ+ D Y C AEN G R + V PY + + +
Sbjct: 295 KTLQLLKVGEED------DGEYRCLAENSLGSARH--AYYVTVEAAPYWLHKPQSHLYGP 346
Query: 138 GNVAVFKCIIPSSVEAYITVVSWEKDTV---SLVSGSRFLITSTGALYIKDVQNEDGLYN 194
G A C + + +T W + + L ++ I GAL + +VQ D +
Sbjct: 347 GETARLDCQVQGRPQPEVT---WRINGIPVEELAKDQKYRI-QRGALILSNVQPSDTMVT 402
Query: 195 YRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMA--GQRVELPCKALGHP 252
+C R+R+ +N+ V PA + D++ MA G L CKA G P
Sbjct: 403 -QCEARNRHG--LLLANAYIYVVQLPAKILTA-----DNQTYMAVQGSTAYLLCKAFGAP 454
Query: 253 EPDYRWL-KDNMPLELSGRFQKTVTGLL-IENIRPSDSGSYVCEVSNRYGTAKVIGRLYV 310
P +WL +D + RF G L I +++ +D+G Y C +N ++ L V
Sbjct: 455 VPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKV 514
Query: 311 KQPLKATISPRKVKSSVGSQVSLSC--SVTGTEDQELSWYRNGEILNPGKNVRITGINHE 368
K + T PR GS+V+ +C S + ++W +G L + I
Sbjct: 515 KDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDG 574
Query: 369 NLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTP 407
L++ + SD G Y C V +L + +L G+P
Sbjct: 575 RLVIHSLDYSDQGNYSC-VASTELDVVESRAQLLVVGSP 612
Score = 76.6 bits (187), Expect = 2e-13
Identities = 69/286 (24%), Positives = 113/286 (39%), Gaps = 16/286 (5%)
Query: 1303 IVLPCKAVGDPS--PAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
+ C+A DPS P++ W D L D + +G +I ++ D G YSC+
Sbjct: 535 VTFTCQASFDPSLQPSITWRGDGRDLQELG--DSDKYFIEDGRLVIHSLDYSDQGNYSCV 592
Query: 1361 ANNNWGSDEIILNLQVQVPPDQ-PRLTVSKT---TSSSITLSWLPGDNGGSSIRGYILQY 1416
A+ E L V P PRL +S T S + +SW P ++ + I Y +++
Sbjct: 593 ASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEF 652
Query: 1417 SEDNS--EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474
+ E+W S P ++ L Y F +TA N GPG S + E +
Sbjct: 653 EDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEA 712
Query: 1475 PQFSKEQELFASINTTR---VRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSK 1531
++ N T + + W D P + +++RP GT Q S
Sbjct: 713 APEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVS-DP 771
Query: 1532 SYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLI 1577
++ + YE++++ NS G + T+ Y G P I
Sbjct: 772 FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQ--VTIGYSGEDYPQAI 815
Score = 55.8 bits (133), Expect = 4e-07
Identities = 41/116 (35%), Positives = 61/116 (52%), Gaps = 7/116 (6%)
Query: 1281 LAKAPARILTFSG-TVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIF 1339
+ + PA+ILT T L CKA G P P+V+W+ D +GT L D R +
Sbjct: 421 VVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL-DEDGTTVLQ--DERFFPY 477
Query: 1340 SNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVP---PDQPRLTVSKTTS 1392
+NG+ IR ++A D+G Y C+A N+ + I+ NL+V+ PR T+ K S
Sbjct: 478 ANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGS 533
Score = 43.9 bits (102), Expect = 0.002
Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 8/80 (10%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKA--EDSGYYSCI 1360
+VL C A G P+P +KW++ S P+ R + N + ++ +K ED G Y C+
Sbjct: 260 LVLECIAEGFPTPTIKWLRPSGPMPA------DRVTYQNHNKTLQLLKVGEEDDGEYRCL 313
Query: 1361 ANNNWGSDEIILNLQVQVPP 1380
A N+ GS + V+ P
Sbjct: 314 AENSLGSARHAYYVTVEAAP 333
Score = 40.8 bits (94), Expect = 0.014
Identities = 91/415 (21%), Positives = 149/415 (35%), Gaps = 34/415 (8%)
Query: 1155 LEKYTNYSIQVLAFTRAGDGVRSEQIFTR-TKEDVPGP-PAGVKAAAASASMVFVSWLPP 1212
L Y +Y+ +V A + G G S T T E P P VK + + ++W P
Sbjct: 679 LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPL 738
Query: 1213 --LKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRG 1270
+ N +Y V + + D F + N S Y + V AV S G+G
Sbjct: 739 RWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLV-VSNTSTFVPYEIKVQAVNSQGKG 797
Query: 1271 NSSEIITVEPLAKAPARILTFSG-------TVTTPWMKDIVLPCKAVGDPSPAVKWMKDS 1323
++ P I G V W + K W + S
Sbjct: 798 PEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGS 857
Query: 1324 NGTPSLVTIDGRRSIF--SNGSFIIRTVKAEDSGYYSCIANNNWGS---DEIILNLQVQV 1378
S I + + S I+ ++ S + A N GS E + V
Sbjct: 858 QRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGV 917
Query: 1379 PPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYS--EDNSEQWGSFPI-SPSERS 1435
P L + +++S+ L W P + + GY+L Y ++ + SF + P R+
Sbjct: 918 PGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRT 977
Query: 1436 YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTR-VRL 1494
+ L +L Y+F L A GPG + + E T+ F +I+ T
Sbjct: 978 HNLTDLSPHLRYRFQLQATTKEGPGE-AIVREGGTMALSGISD-----FGNISATAGENY 1031
Query: 1495 NLIGW--NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQ 1547
+++ W +G C F + ++ G SLS Y+ Y+ T ++LQ
Sbjct: 1032 SVVSWVPKEGQCNF-RFHILFKALG----EEKGGASLSPQYVSYNQSSYTQWDLQ 1081
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 243 bits (619), Expect = 2e-63
Identities = 250/1012 (24%), Positives = 428/1012 (42%), Gaps = 88/1012 (8%)
Query: 310 VKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGIN--H 367
++ P+ SPR++ +SL C +G + + W R+G P + + +T H
Sbjct: 27 MEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPH 86
Query: 368 ENLIM-----DHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKV-VSPA 421
+ + G Y+CF +A + ++ +G PK + V V
Sbjct: 87 SGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEG 146
Query: 422 EPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGV 481
E V L CN + P + ++ + R++ + GN+ ++S D
Sbjct: 147 ESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT--MGQNGNLYFANVLTSDNHSD--- 201
Query: 482 YRCTAN-NSAGVVLYQARINVRGPAS-------------IRPMKNITAIAGRDTYIHCRV 527
Y C A+ ++ + I++R A+ ++ A+ G+ + C
Sbjct: 202 YICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIA 261
Query: 528 IGYPYYSIKWYKNSNLLPFNHRQVAFEN-NGTLKLSDVQKEVDEGEYTCNVLVQPQLSTS 586
G+P +IKW + S +P + +V ++N N TL+L V +E D+GEY C L + L ++
Sbjct: 262 EGFPTPTIKWLRPSGPMPAD--RVTYQNHNKTLQLLKVGEE-DDGEYRC--LAENSLGSA 316
Query: 587 Q-SVHVTVKVPPF-IQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVT 644
+ + +VTV+ P+ + + + G+ + C V P +TW+ +G P+
Sbjct: 317 RHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQP-EVTWRINGIPVEELAKDQ 375
Query: 645 IDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPRDQD-GI 702
I +L +SN+ C ARN + + + +V++P K + +
Sbjct: 376 KYRIQ-RGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAV 434
Query: 703 YGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSG 762
G L C A G PVP++ W G V Q + R +NG+L I+ + D+G
Sbjct: 435 QGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDE------RFFPYANGTLGIRDLQANDTG 488
Query: 763 YYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPI--IVR 820
Y C +ND +V+ L VK IT P +T+ +G + +C A + + +
Sbjct: 489 RYFCLAANDQN-NVTIMANLKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSIT 547
Query: 821 WEKEDRIINP--EMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGII 878
W + R + + +Y + E G VI +L D G +SC A
Sbjct: 548 WRGDGRDLQELGDSDKYFI---EDGRLVIHSLDY-----SDQGNYSCVASTELDVVESRA 599
Query: 879 QLTVQEPPDP-PEIEIKDVKART---ITLRWTMGFDGNSPITGYDIECKNKS---DSWDS 931
QL V P P P + + D+ T + + W+ D N+PI YDIE ++K + W S
Sbjct: 600 QLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYS 659
Query: 932 AQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN-ELTITADEAAPDGPPQE 990
+ P ++T + + P Y+ R+ A N+ G EPS T+ EAAP+ P +
Sbjct: 660 LGKV----PGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVD 715
Query: 991 VHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYT 1050
V E + ++ +TWK + N Y++ +R T G +Q I+S
Sbjct: 716 VKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVS------DPFLV 769
Query: 1051 LDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWS 1110
+ N + F Y + VQA N G GP Q I + ED P PE + ++ + W
Sbjct: 770 VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWR 829
Query: 1111 TLSKEALNGILQGFRVIYWANLMDGELG------EIKNITTTQPSLELDGLEKYTNYSIQ 1164
+ + G L+G+ V YW + + + S+ L GL Y++Y ++
Sbjct: 830 PVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLE 889
Query: 1165 VLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTV 1224
V AF G G SE F+ T E VPG P + S + + + W PPL NG++ Y V
Sbjct: 890 VQAFNGRGSGPASEFTFS-TPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGY-V 947
Query: 1225 FCSHPYPT----VISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNS 1272
HP +S P+ ++ + +LS + +Y + A T G G +
Sbjct: 948 LSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEA 999
Score = 174 bits (442), Expect = 6e-43
Identities = 255/1039 (24%), Positives = 418/1039 (40%), Gaps = 122/1039 (11%)
Query: 242 VELPCKALGHPEPDYRWLKDNMPLE-------------LSGRFQKTVTGLLIENIRPSDS 288
+ L C+A G PE +RW +D + + SG F T+TG N
Sbjct: 48 ISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSF--TITG-NNSNFAQRFQ 104
Query: 289 GSYVCEVSNRYGTA-----KVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQ 343
G Y C SN+ GTA +++ K P K T+ P +V+ G V L C+ + +
Sbjct: 105 GIYRCFASNKLGTAMSHEIRLMAEGAPKWP-KETVKPVEVEE--GESVVLPCNPPPSAEP 161
Query: 344 ELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGA-YQC---------FVRKDKLS 393
++ N +IL+ ++ R+T + NL +++ SD + Y C ++K+ +
Sbjct: 162 LRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPID 221
Query: 394 AQDYVQVVLEDGTPKII---SAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKG 450
+ + D P+++ ++ S V +P+ L C +G P PTI W P+
Sbjct: 222 LRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPM--- 278
Query: 451 GSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR-GPASIRP 509
+ R++ + + L + D G YRC A NS G + + V P +
Sbjct: 279 PADRVTYQ--NHNKTLQLLKVGE---EDDGEYRCLAENSLGSARHAYYVTVEAAPYWLHK 333
Query: 510 MKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFE-NNGTLKLSDVQKEV 568
++ G + C+V G P + W N + + + G L LS+VQ
Sbjct: 334 PQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPS- 392
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSI--GQRVFIPCVVVSGDLPI 626
D C + L + + V++P I + + G ++ C +P
Sbjct: 393 DTMVTQCEARNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPS 452
Query: 627 TITWQKDGRPIPGSLGVTIDNIDF---TSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQ 683
+DG V D F +L I +L G Y C+A N+ V +
Sbjct: 453 VQWLDEDGTT------VLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMAN 506
Query: 684 LIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYP--VPTIVWKFSKGAGVPQFQPIALNG 741
L V+ + PR G V C A P P+I W +G G Q + +
Sbjct: 507 LKVKDATQITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITW---RGDG-RDLQELGDSD 562
Query: 742 RIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV----KIPAMITSYPNTT 797
+ + +G L+I + D G Y C S ++ S++ L V +P ++ S +
Sbjct: 563 K-YFIEDGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLS--DLH 619
Query: 798 LATQGQKKEMSCTAHGEKPIIVRW--EKEDRIINPEMARYLVSTKEVGEEVISTLQILPT 855
L TQ Q + A I ++ E ED+ + PE ++ K G + +TL++ P
Sbjct: 620 LLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPE--KWYSLGKVPGNQTSTTLKLSPY 677
Query: 856 VREDSGFFSCHAINSYGE-DRGIIQLTVQEPPDPPEIEIKDVKAR-------TITLRWTM 907
V F AIN YG + + TV P PE DVK IT +
Sbjct: 678 VHYT---FRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLR 734
Query: 908 GFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSST---YSIRMYAKN 964
D N+P Y ++ W Q+ S + + +ST Y I++ A N
Sbjct: 735 WMDWNAPQVQYRVQ-------WRPQGTRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVN 787
Query: 965 RIGKSEPSNELTI-TADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIG 1023
GK P ++TI + E P P+ +E ++S ++ V W+ G +RGY +
Sbjct: 788 SQGKG-PEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVT 846
Query: 1024 Y-REYSTGGNFQFNIIS--VDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEII 1080
Y RE S + + +I V ++ L L ++ Y L VQA N G+GP+S E
Sbjct: 847 YWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPAS-EFT 905
Query: 1081 TTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEI 1140
+T E VP + PE + S S+ + W NG+L G+ V+ + L +G G++
Sbjct: 906 FSTPEGVPGH-PEALHLECQSNTSLLLRWQPPLSH--NGVLTGY-VLSYHPLDEGGKGQL 961
Query: 1141 KNITTTQPSL---ELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVK- 1196
+ P L L L + Y Q+ A T+ G G E I +E +G+
Sbjct: 962 -SFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPG---EAI---VREGGTMALSGISD 1014
Query: 1197 ----AAAASASMVFVSWLP 1211
+A A + VSW+P
Sbjct: 1015 FGNISATAGENYSVVSWVP 1033
Score = 100 bits (249), Expect = 1e-20
Identities = 140/606 (23%), Positives = 218/606 (35%), Gaps = 49/606 (8%)
Query: 18 EDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHP 77
E+L S + +V T + C A+G P V RW T + + H P
Sbjct: 24 EELMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRW---TRDGV-------HFKP 73
Query: 78 NGTL--QIFPFPPSSFSTLIHDNT---------YYCTAENPSGKIRSQDVHIKAVLREPY 126
L ++ P S T+ +N+ Y C A N G S ++ + A +
Sbjct: 74 KEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKW 133
Query: 127 TVR-VEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKD 185
V+ + G V C P S E + + + + R + G LY +
Sbjct: 134 PKETVKPVEVEEGESVVLPCNPPPSAEP-LRIYWMNSKILHIKQDERVTMGQNGNLYFAN 192
Query: 186 VQNEDGLYNYRCITRHRYTGETRQSNSARLFV---SDPANSAPSIL---DGFDHRKAMAG 239
V D +Y C T Q L V + + P +L + H A+ G
Sbjct: 193 VLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPRLLFPTNSSSHLVALQG 252
Query: 240 QRVELPCKALGHPEPDYRWLKDNMPLELSG-RFQKTVTGLLIENIRPSDSGSYVCEVSNR 298
Q + L C A G P P +WL+ + P+ +Q L + + D G Y C N
Sbjct: 253 QPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENS 312
Query: 299 YGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGK 358
G+A+ + V+ P+ G L C V G E++W NG +
Sbjct: 313 LGSARHAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRINGIPVEELA 372
Query: 359 NVRITGINHENLIMDHMVKSDGGAYQCFVRK--DKLSAQDYVQVVLEDGTPKIISAFSEK 416
+ I LI+ ++ SD QC R L A Y+ VV KI++A ++
Sbjct: 373 KDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVV--QLPAKILTADNQT 430
Query: 417 VVS-PAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQ 475
++ L+C G P+P++ W LD+D R L I Q
Sbjct: 431 YMAVQGSTAYLLCKAFGAPVPSVQW-LDEDGTTVLQDERFFPYANGT------LGIRDLQ 483
Query: 476 VRDGGVYRCTANNSAGVVLYQARINVRGPASIR--PMKNITAIAGRDTYIHCRVIGYPYY 533
D G Y C A N V A + V+ I P I R T+ C+ P
Sbjct: 484 ANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSRVTFT-CQASFDPSL 542
Query: 534 --SIKWYKNS-NLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVH 590
SI W + +L F +G L + + D+G Y+C + + S++
Sbjct: 543 QPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYS-DQGNYSCVASTELDVVESRAQL 601
Query: 591 VTVKVP 596
+ V P
Sbjct: 602 LVVGSP 607
Score = 76.6 bits (187), Expect = 2e-13
Identities = 69/286 (24%), Positives = 113/286 (39%), Gaps = 16/286 (5%)
Query: 1303 IVLPCKAVGDPS--PAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
+ C+A DPS P++ W D L D + +G +I ++ D G YSC+
Sbjct: 530 VTFTCQASFDPSLQPSITWRGDGRDLQELG--DSDKYFIEDGRLVIHSLDYSDQGNYSCV 587
Query: 1361 ANNNWGSDEIILNLQVQVPPDQ-PRLTVSKT---TSSSITLSWLPGDNGGSSIRGYILQY 1416
A+ E L V P PRL +S T S + +SW P ++ + I Y +++
Sbjct: 588 ASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEF 647
Query: 1417 SEDNS--EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474
+ E+W S P ++ L Y F +TA N GPG S + E +
Sbjct: 648 EDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEA 707
Query: 1475 PQFSKEQELFASINTTR---VRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSK 1531
++ N T + + W D P + +++RP GT Q S
Sbjct: 708 APEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVS-DP 766
Query: 1532 SYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLI 1577
++ + YE++++ NS G + T+ Y G P I
Sbjct: 767 FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQ--VTIGYSGEDYPQAI 810
Score = 55.8 bits (133), Expect = 4e-07
Identities = 41/116 (35%), Positives = 61/116 (52%), Gaps = 7/116 (6%)
Query: 1281 LAKAPARILTFSG-TVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIF 1339
+ + PA+ILT T L CKA G P P+V+W+ D +GT L D R +
Sbjct: 416 VVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL-DEDGTTVLQ--DERFFPY 472
Query: 1340 SNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVP---PDQPRLTVSKTTS 1392
+NG+ IR ++A D+G Y C+A N+ + I+ NL+V+ PR T+ K S
Sbjct: 473 ANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGS 528
Score = 43.9 bits (102), Expect = 0.002
Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 8/80 (10%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKA--EDSGYYSCI 1360
+VL C A G P+P +KW++ S P+ R + N + ++ +K ED G Y C+
Sbjct: 255 LVLECIAEGFPTPTIKWLRPSGPMPA------DRVTYQNHNKTLQLLKVGEEDDGEYRCL 308
Query: 1361 ANNNWGSDEIILNLQVQVPP 1380
A N+ GS + V+ P
Sbjct: 309 AENSLGSARHAYYVTVEAAP 328
Score = 40.8 bits (94), Expect = 0.014
Identities = 91/415 (21%), Positives = 149/415 (35%), Gaps = 34/415 (8%)
Query: 1155 LEKYTNYSIQVLAFTRAGDGVRSEQIFTR-TKEDVPGP-PAGVKAAAASASMVFVSWLPP 1212
L Y +Y+ +V A + G G S T T E P P VK + + ++W P
Sbjct: 674 LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPL 733
Query: 1213 --LKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRG 1270
+ N +Y V + + D F + N S Y + V AV S G+G
Sbjct: 734 RWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDPFLV-VSNTSTFVPYEIKVQAVNSQGKG 792
Query: 1271 NSSEIITVEPLAKAPARILTFSG-------TVTTPWMKDIVLPCKAVGDPSPAVKWMKDS 1323
++ P I G V W + K W + S
Sbjct: 793 PEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGS 852
Query: 1324 NGTPSLVTIDGRRSIF--SNGSFIIRTVKAEDSGYYSCIANNNWGS---DEIILNLQVQV 1378
S I + + S I+ ++ S + A N GS E + V
Sbjct: 853 QRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFSTPEGV 912
Query: 1379 PPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYS--EDNSEQWGSFPI-SPSERS 1435
P L + +++S+ L W P + + GY+L Y ++ + SF + P R+
Sbjct: 913 PGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRT 972
Query: 1436 YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTR-VRL 1494
+ L +L Y+F L A GPG + + E T+ F +I+ T
Sbjct: 973 HNLTDLSPHLRYRFQLQATTKEGPGE-AIVREGGTMALSGISD-----FGNISATAGENY 1026
Query: 1495 NLIGW--NDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQ 1547
+++ W +G C F + ++ G SLS Y+ Y+ T ++LQ
Sbjct: 1027 SVVSWVPKEGQCNF-RFHILFKALG----EEKGGASLSPQYVSYNQSSYTQWDLQ 1076
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 242 bits (618), Expect = 2e-63
Identities = 252/1024 (24%), Positives = 416/1024 (40%), Gaps = 90/1024 (8%)
Query: 306 GRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGI 365
G +++K+P + S +++L C G W NG ++ R +
Sbjct: 25 GPVFIKEPSNSIFPV----GSEDKKITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYK-L 79
Query: 366 NHENLIMDHMVKS-DGGAYQCFVRKDK---LSAQDYVQVV-LEDGTPKIISAFSEKVVSP 420
N NL++ + ++ D G YQCF +S + +Q LE+ K+ S S V
Sbjct: 80 NGGNLVVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVS---VRE 136
Query: 421 AEPVSLMCNVKGTPLP-----TITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQ 475
+ V L+C P P + W ++ P R + ++ E +L IS +
Sbjct: 137 GQGVVLLCG----PPPHSGELSYAWIFNEYPSFVEEDSR--RFVSQE---TGHLYISKVE 187
Query: 476 VRDGGVYRCTANN-----------------SAGVV-LYQARINVRGPASIRPMKNITAIA 517
D G Y C + S GV+ Y+ +I V+ P + + A
Sbjct: 188 PSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFP------ETLPAAK 241
Query: 518 GRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNV 577
G + C +G P I W + S+ LPF+ + + +G L++ + Q+E D G Y C
Sbjct: 242 GSTVKLECFALGNPIPQINW-RRSDGLPFSSKIKLRKFSGVLEIPNFQQE-DAGSYECIA 299
Query: 578 LVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPI 637
+ ++ P ++Q + ++ ++ C SG + W K+G +
Sbjct: 300 ENSRGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRA-SGKPKPSYRWLKNGAAL 358
Query: 638 PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQL-IVRVPPKFVVQP 696
I+N +L ISNLS+ +G + CIA N+ V ++L +V P F P
Sbjct: 359 VLEERTQIEN----GALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNP 414
Query: 697 RDQ--DGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIK 754
+ G V L+C P WK KG + + RI +L++G L I
Sbjct: 415 MKKLVQVQVGSLVSLDCKPRASPRALSSWK--KGD-----VSVQEHERISLLNDGGLKIA 467
Query: 755 HVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGE 814
+V + D+G Y C N G + + +L V P IT P+ + G+ + C +
Sbjct: 468 NVTKADAGTYTCMAENQFGK-ANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHD 526
Query: 815 K--PIIVRWEKEDRIINPEMARYLVST---KEVGEEVISTLQILPTVREDSGFFSCHAIN 869
II W N +A + ++VG L I + SG + C
Sbjct: 527 PLLDIIFTW-----YFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQT 581
Query: 870 SYGEDRGIIQLTVQEPPDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNK-SD 927
L V+ P PPE +++ ++ T L W G D +SP+ Y I+ + S
Sbjct: 582 GVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSV 641
Query: 928 SWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPS-NELTITADEAAPD 985
W + +V + ++AT+++++P Y R+ A N+IG EPS + +EA P+
Sbjct: 642 GWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPE 701
Query: 986 GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGD 1045
PP EV+ S + +TW + LQNG GY + +R Q + S DT
Sbjct: 702 VPPSEVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTP-- 759
Query: 1046 SEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESI 1105
V+ +++ ++ Y + V N G GP S + E+ P+ P V A + S I
Sbjct: 760 RYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEI 819
Query: 1106 SISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQV 1165
+SW+T+ + NG L G+ V YW E + + S L GL+ Y V
Sbjct: 820 EVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAV 879
Query: 1166 LAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSW--LPPLKLNGIIRKYT 1223
A+ AG G S + TK+ P P G A+ + V ++W + ++ + Y
Sbjct: 880 RAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYK 939
Query: 1224 VFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAK 1283
VF + + S +P Y + V A T G G SSE I + +
Sbjct: 940 VFYRTSSQNNVQVLNTNKTSAELVLP---IKEDYIIEVKATTDGGDGTSSEQIRIPRITS 996
Query: 1284 APAR 1287
AR
Sbjct: 997 MDAR 1000
Score = 197 bits (500), Expect = 1e-49
Identities = 246/1035 (23%), Positives = 418/1035 (40%), Gaps = 141/1035 (13%)
Query: 215 LFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKT 274
+F+ +P+NS + G + +K + L C+A G+P P YRW + +++S +
Sbjct: 27 VFIKEPSNSIFPV--GSEDKK------ITLHCEARGNPSPHYRWQLNGSDIDMSMEHRYK 78
Query: 275 VTGLLIENIRPS---DSGSYVCEVSNRYGTAKVIGR------LYV---KQPLKATISPRK 322
+ G + I P+ D+G+Y C +N GT ++ R Y+ K +++T+S R+
Sbjct: 79 LNGGNLVVINPNRNWDTGTYQCFATNSLGT--IVSREAKLQFAYLENFKTKMRSTVSVRE 136
Query: 323 VKSSVGSQVSLSCSVTGTEDQELSW---YRNGEILNPGKNVRITGINHENLIMDHMVKSD 379
G V L C ELS+ + + R +L + + SD
Sbjct: 137 -----GQGVVLLCG-PPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSD 190
Query: 380 GGAYQC----FVRKDKLSAQDYVQVVLEDGT-----PKIISAFSEKV-VSPAEPVSLMCN 429
G Y C V ++ V+ DG PKI F E + + V L C
Sbjct: 191 VGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECF 250
Query: 430 VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNS 489
G P+P I W D G S++ + + V L I + Q D G Y C A NS
Sbjct: 251 ALGNPIPQINWRRSD------GLPFSSKIKLRKFSGV--LEIPNFQQEDAGSYECIAENS 302
Query: 490 AGVVLYQARINVRG-PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNH 548
G + + R+ P ++ +K++ Y CR G P S +W KN L
Sbjct: 303 RGKNVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEE 362
Query: 549 RQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQL-STSQSVHVTVKVPPFIQ-PF-EFP 605
R NG L +S++ D G + C + L +S + V P F + P +
Sbjct: 363 RTQI--ENGALTISNL-SVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLV 419
Query: 606 RFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNG 665
+ +G V + C + ++ +W+K + +++ N L+I+N++ G
Sbjct: 420 QVQVGSLVSLDCKPRASPRALS-SWKKGDVSVQEHERISLLN---DGGLKIANVTKADAG 475
Query: 666 NYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKF 725
YTC+A N+ + L+V P + + P + D G++VIL C + P+ I++ +
Sbjct: 476 TYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTW 535
Query: 726 SKGAGVPQFQPIALN-GRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
+ F+ + ++ S+G L+I+++ + SG Y+C V V + VS + L V
Sbjct: 536 YFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDS-VSSAADLIV 594
Query: 785 K----IPAMITSYPNTTLATQGQKKE--------MSCTAHGEKPIIVRWEKEDRI----- 827
+ P + T Q KE +S + P V W+ +
Sbjct: 595 RGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVID 654
Query: 828 ----------INP--EMARYLVSTKEVG-------EEVISTLQILPTVREDSGFFSCHAI 868
+NP E +V++ ++G E + T + +P V +
Sbjct: 655 GKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSE-------V 707
Query: 869 NSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKS-D 927
N G R +L + P P E++ N GY + +
Sbjct: 708 NGGGGSRS--ELVITWDPVPEELQ-------------------NGEGFGYVVAFRPLGVT 746
Query: 928 SWDSAQRTKDVSPQ--LNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD 985
+W T +P+ + +I+ P S Y +++ N G+ S T+ + E P
Sbjct: 747 TWIQTVVTSPDTPRYVFRNESIV---PYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPT 803
Query: 986 GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGD 1045
P +V +SS I V+W L NG + GY++ Y GG + + + +G+
Sbjct: 804 VAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEV---RYWNGGGKEESSSKMKVAGN 860
Query: 1046 SEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESI 1105
L L Y V+A N AG GP S + TT + PS PP NV AT + +
Sbjct: 861 ETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTK-V 919
Query: 1106 SISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQV 1165
++W + + G++V Y + + ++ + T + S EL L +Y I+V
Sbjct: 920 LLNWEQVKAMENESEVTGYKVFYRTSSQN----NVQVLNTNKTSAEL-VLPIKEDYIIEV 974
Query: 1166 LAFTRAGDGVRSEQI 1180
A T GDG SEQI
Sbjct: 975 KATTDGGDGTSSEQI 989
Score = 112 bits (279), Expect = 5e-24
Identities = 135/550 (24%), Positives = 208/550 (37%), Gaps = 38/550 (6%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAE 105
C A G P RW L G +I D+ NG + P ++ T TY C A
Sbjct: 50 CEARGNPSPHYRWQL-NGSDI-DMSMEHRYKLNGGNLVVINPNRNWDT----GTYQCFAT 103
Query: 106 NPSGKIRSQDVHIKAVLREPYTVRVEDQKTMR-GNVAVFKC-IIPSSVEAYITVVSWEKD 163
N G I S++ ++ E + ++ ++R G V C P S E + E
Sbjct: 104 NSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYP 163
Query: 164 TVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDP--- 220
+ RF+ TG LYI V+ D + NY C+ T + L +
Sbjct: 164 SFVEEDSRRFVSQETGHLYISKVEPSD-VGNYTCVVTSMVTNARVLGSPTPLVLRSDGVM 222
Query: 221 ANSAPSILDGF-DHRKAMAGQRVELPCKALGHPEPDYRWLK-DNMPLELSGRFQKTVTGL 278
P I F + A G V+L C ALG+P P W + D +P + +K L
Sbjct: 223 GEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVL 282
Query: 279 LIENIRPSDSGSYVCEVSNRYGTAKVIGRL-YVKQPLKATISPRKVKSSVGSQVSLSCSV 337
I N + D+GSY C N G GRL Y +P + + V+ +V + C
Sbjct: 283 EIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAKPHWVQLI-KDVEIAVEDSLYWECRA 341
Query: 338 TGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDY 397
+G W +NG L + T I + L + ++ +D G +QC
Sbjct: 342 SGKPKPSYRWLKNGAALVLEER---TQIENGALTISNLSVTDSGMFQCIAENKHGLVYSS 398
Query: 398 VQVVLEDGTPKIISAFSEKV--VSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRI 455
++ + P +K+ V VSL C + +P +W D + + H
Sbjct: 399 AELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQE---HER 455
Query: 456 SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR-PMKNIT 514
++ G L I++ D G Y C A N G + V P I N+
Sbjct: 456 ISLLNDGG-----LKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMD 510
Query: 515 AIAGRDTYIHCRVIGYPYYSI--KWYKNSNLLPF-----NHRQVAFENNGTLKLSDVQKE 567
G + C+V P I WY N L F + +V ++G L + ++Q +
Sbjct: 511 VSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLK 570
Query: 568 VDEGEYTCNV 577
G+Y C V
Sbjct: 571 -HSGKYVCMV 579
Score = 72.8 bits (177), Expect = 3e-12
Identities = 85/374 (22%), Positives = 149/374 (39%), Gaps = 36/374 (9%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAE 105
C A G P + W + G +R +G L+I F + Y C AE
Sbjct: 249 CFALGNPIPQINWRRSDGLPFSSKIKLRKF--SGVLEIPNFQQEDAGS------YECIAE 300
Query: 106 NPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTV 165
N GK ++ + + + ++D + + ++C + W K+
Sbjct: 301 NSRGKNVARG-RLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYR---WLKNGA 356
Query: 166 SLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRY-----TGETRQSNSARLFVSDP 220
+LV R I + GAL I ++ D ++CI +++ + E + SA F +P
Sbjct: 357 ALVLEERTQIEN-GALTISNLSVTDSGM-FQCIAENKHGLVYSSAELKVVASAPDFSKNP 414
Query: 221 ANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG-LL 279
+ G V L CK P W K ++ ++ R G L
Sbjct: 415 MKKLVQV---------QVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLK 465
Query: 280 IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTG 339
I N+ +D+G+Y C N++G A L V +P + T++P + SVG V L C V
Sbjct: 466 IANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQH 525
Query: 340 TE--DQELSWYRNGEILNPGKN----VRITGINHENLIMDHMVKSDGGAYQCFVRKDKLS 393
D +WY NG + + K+ ++ G + +L++ ++ G Y C V+ S
Sbjct: 526 DPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDS 585
Query: 394 AQDYVQVVLEDGTP 407
+++ G+P
Sbjct: 586 VSSAADLIVR-GSP 598
Score = 55.8 bits (133), Expect = 4e-07
Identities = 68/328 (20%), Positives = 131/328 (39%), Gaps = 26/328 (7%)
Query: 1247 RIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLP 1306
+I N+++ + +A G+ N + + V P RI + + ++LP
Sbjct: 465 KIANVTKADAGTYTCMAENQFGKANGTTHLVVTE----PTRITLAPSNMDVSVGESVILP 520
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDG----RRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
C+ DP + + NG + DG + S+G +IR ++ + SG Y C+
Sbjct: 521 CQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQ 580
Query: 1363 NNWGSDEIILNLQVQVPPDQP-RLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNS 1421
S +L V+ P P + V + T ++ LSW G + S + Y +Q S
Sbjct: 581 TGVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFS 640
Query: 1422 EQWGSFPISP---SERSYRLENLKCGTW--YKFTLTAQNGVGPGRISEIIE-AKTLGKEP 1475
W + P +++ ++ W Y+F + A N +G G S E +T P
Sbjct: 641 VGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVP 700
Query: 1476 QFSKEQELFASINTTRVRLNLIGWNDGGCPITS-----FTLEYRPFGTTVWTTAQRTSLS 1530
+ + + + + +I W+ + + + + +RP G T W TS
Sbjct: 701 EVPPSEVNGGGGSRSEL---VITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPD 757
Query: 1531 KSYILY---DLQEATWYELQMRVCNSAG 1555
++ + + YE+++ V N+ G
Sbjct: 758 TPRYVFRNESIVPYSPYEVKVGVYNNKG 785
Score = 42.4 bits (98), Expect = 0.005
Identities = 21/60 (35%), Positives = 31/60 (51%), Gaps = 5/60 (8%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C+A G P P+ +W+K NG ++ R+ NG+ I + DSG + CIA N G
Sbjct: 339 CRASGKPKPSYRWLK--NGAALVLE---ERTQIENGALTISNLSVTDSGMFQCIAENKHG 393
Score = 40.0 bits (92), Expect = 0.023
Identities = 21/67 (31%), Positives = 35/67 (52%), Gaps = 2/67 (2%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
K I L C+A G+PSP +W NG+ ++++ R + +I + D+G Y C
Sbjct: 44 KKITLHCEARGNPSPHYRW--QLNGSDIDMSMEHRYKLNGGNLVVINPNRNWDTGTYQCF 101
Query: 1361 ANNNWGS 1367
A N+ G+
Sbjct: 102 ATNSLGT 108
Score = 39.3 bits (90), Expect = 0.039
Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
+ L C A+G+P P + W + S+G P I R+ +G I + ED+G Y CIA
Sbjct: 245 VKLECFALGNPIPQINWRR-SDGLPFSSKIKLRKF---SGVLEIPNFQQEDAGSYECIAE 300
Query: 1363 NNWGSD 1368
N+ G +
Sbjct: 301 NSRGKN 306
Score = 36.6 bits (83), Expect = 0.25
Identities = 58/272 (21%), Positives = 96/272 (35%), Gaps = 41/272 (15%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
+ L CK P W K V R S+ ++G I V D+G Y+C+A
Sbjct: 427 VSLDCKPRASPRALSSWKKGDVS----VQEHERISLLNDGGLKIANVTKADAGTYTCMAE 482
Query: 1363 NNWGSDEIILNLQVQVP------PDQPRLTVSKTT----------SSSITLSWLPGDNGG 1406
N +G +L V P P ++V ++ I +W
Sbjct: 483 NQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWY------ 536
Query: 1407 SSIRGYILQYSEDNS--EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISE 1464
G + + +D S E+ G S + N++ K+ Q GV +
Sbjct: 537 --FNGALADFKKDGSHFEKVG----GSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAA 590
Query: 1465 IIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYR-PF--GTTVW 1521
+ + P+ K E I T +L+ D P+ S++++ R PF G
Sbjct: 591 DLIVRGSPGPPENVKVDE----ITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTV 646
Query: 1522 TTAQRTSLSKSYILYDLQEATWYELQMRVCNS 1553
TT K++ ++ W E + RV S
Sbjct: 647 TTVPEVIDGKTHTATVVELNPWVEYEFRVVAS 678
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 240 bits (612), Expect = 1e-62
Identities = 227/853 (26%), Positives = 360/853 (42%), Gaps = 67/853 (7%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAE 105
C + +PP + W L GE + P +R + LQI + + L Y C A
Sbjct: 3643 CKSDAVPPPVITW-LRNGERLQATPRVRILSGGRYLQI------NNADLGDTANYTCVAS 3695
Query: 106 NPSGKIRSQDVHIKAVLREPYTVRVEDQKT--MRGNVAVFKCIIPSSVEAYITVVSWEKD 163
N +GK + + + P ++ Q + V +CI IT W KD
Sbjct: 3696 NIAGKTTREFI---LTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRIT---WRKD 3749
Query: 164 TVSLVSG-SRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPAN 222
L +R+ I G L+I+ D Y C+ T + + R + +
Sbjct: 3750 GAVLAGNHARYSILENGFLHIQSAHVTD-TGRYLCMA-------TNAAGTDRRRIDLQVH 3801
Query: 223 SAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELS---GRFQKTVTGLL 279
PSI G + + + L C+A G P+P W K+ L + ++ +G L
Sbjct: 3802 VPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSL 3861
Query: 280 IENIRPS--DSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSV 337
+ I PS D+ +Y C V+N G K L V+ P P + + ++C+
Sbjct: 3862 VI-ISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTA 3920
Query: 338 TGTEDQELSWYRNGEILNP-GKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQD 396
+G + W +NG L P G RI ++ + + G Y C R SA
Sbjct: 3921 SGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL--NHAGRYTCVARNAAGSAHR 3978
Query: 397 YVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRIS 456
+V + + + P I SE V P+ L C GTP P ITW + + G R
Sbjct: 3979 HVTLHVHE-PPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSG--RNH 4035
Query: 457 QMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRP-MKNITA 515
++ S G L IS + D G Y C A N AG L + ++NV+ P I P +K
Sbjct: 4036 AVLPSGG-----LQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVI 4090
Query: 516 IAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
+ + C G P I W+K+ + + RQ ++G+L+++ VQ D G YTC
Sbjct: 4091 AVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVL-SSGSLQIAFVQPG-DAGHYTC 4148
Query: 576 NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQ--RVFIPCVVVSGDLPITITWQKD 633
+ S+S S +TV VPP I+ E +++ + + +PCV P I W+KD
Sbjct: 4149 -MAANVAGSSSTSTKLTVHVPPRIRSTE-GHYTVNENSQAILPCVADGIPTP-AINWKKD 4205
Query: 634 GRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFV 693
+ LG + L + N+ L +G YTC+A N A H L V V P F
Sbjct: 4206 NVLLANLLGKY--TAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFT 4263
Query: 694 VQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLI 753
P D G+ + L+C A G P+P + W F+ F + NG + L+I
Sbjct: 4264 ELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSV--NG------HSELVI 4315
Query: 754 KHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHG 813
+ V +EDSG Y+C N VG + + P YP+ + G ++C G
Sbjct: 4316 ERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKG 4375
Query: 814 EKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGE 873
+ ++W ++ ++ E++ + +++G +L I TV ED+G ++C A N G
Sbjct: 4376 DPTPTIQWNRKG--VDIEISHRI---RQLGN---GSLAIYGTVNEDAGDYTCVATNEAGV 4427
Query: 874 DRGIIQLTVQEPP 886
+ LT+Q PP
Sbjct: 4428 VERSMSLTLQSPP 4440
Score = 217 bits (553), Expect = 8e-56
Identities = 238/922 (25%), Positives = 371/922 (40%), Gaps = 93/922 (10%)
Query: 32 QEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSF 91
Q +V T++ C A G+P + W G + + NG L I
Sbjct: 3720 QSLVILLNKSTVLECIAEGVPTPRITWR-KDGAVLAGNHARYSILENGFLHI------QS 3772
Query: 92 STLIHDNTYYCTAENPSGKIRSQ---DVHIKAVLREP---YTVRVEDQKTMRGNVA-VFK 144
+ + Y C A N +G R + VH+ + TV V Q T+ + K
Sbjct: 3773 AHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPK 3832
Query: 145 CIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYT 204
I ++ V +++ L+S +I S D Y C +
Sbjct: 3833 PSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSV---------DDTATYECTVTN--- 3880
Query: 205 GETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMP 264
G + L V P + A D + A A + C A G P P W K+ +
Sbjct: 3881 GAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPA----VITCTASGVPFPSIHWTKNGIR 3936
Query: 265 LELSGRFQKTVTGLLIENIRP--SDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRK 322
L G + ++ IE + + +G Y C N G+A L+V +P P +
Sbjct: 3937 LLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSE 3996
Query: 323 VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHE-----NLIMDHMVK 377
+ + + + L C TGT ++W + G NV +G NH L + V+
Sbjct: 3997 LHVILNNPILLPCEATGTPSPFITWQKEGI------NVNTSGRNHAVLPSGGLQISRAVR 4050
Query: 378 SDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISA-FSEKVVSPAEPVSLMCNVKGTPLP 436
D G Y C + +A +++ ++ P +IS E V++ +P++L C G P P
Sbjct: 4051 EDAGTYMCVAQNPAGTALGKIKLNVQ--VPPVISPHLKEYVIAVDKPITLSCEADGLPPP 4108
Query: 437 TITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQ 496
ITW D I++ I Q + S G+ L I+ Q D G Y C A N AG
Sbjct: 4109 DITWHKDGRAIVES----IRQRVLSSGS----LQIAFVQPGDAGHYTCMAANVAGSSSTS 4160
Query: 497 ARINVRGPASIRPMK-NITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFEN 555
++ V P IR + + T + C G P +I W K++ LL + E
Sbjct: 4161 TKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEP 4220
Query: 556 NGTLKLSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQR 612
G L L +V E D G YTC N + + S +VHV +P F + + G++
Sbjct: 4221 YGELILENVVLE-DSGFYTCVANNAAGEDTHTVSLTVHV---LPTFTELPGDVSLNKGEQ 4276
Query: 613 VFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIAR 672
+ + C LP +TW + IP D+++ S L I +S +G Y C A
Sbjct: 4277 LRLSCKATGIPLP-KLTWTFNNNIIPAHF----DSVNGHSELVIERVSKEDSGTYVCTAE 4331
Query: 673 NEAAAVEHQSQLIVRVPPKFVVQ-PRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGV 731
N V+ + V+ PP F P + G ILNC +G P PTI W KG
Sbjct: 4332 NSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWN-RKGVD- 4389
Query: 732 PQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMIT 791
I ++ RI+ L NGSL I V ED+G Y C +N+ G V +SM LT++ P +IT
Sbjct: 4390 -----IEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGV-VERSMSLTLQSPPIIT 4443
Query: 792 SYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQ 851
P T+ G K ++C A GE + W ++ I+ + ++S ++L
Sbjct: 4444 LEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSN--------NSLY 4495
Query: 852 ILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEI---------KDVKARTIT 902
I +ED+ F C A N G + + VQ + K ++ R+
Sbjct: 4496 IADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRL 4555
Query: 903 LRWTMGFDGNSPITGYDIECKN 924
+ +G P G D+E +N
Sbjct: 4556 CNQPLPANGGKPCQGSDLEMRN 4577
Score = 216 bits (550), Expect = 2e-55
Identities = 234/894 (26%), Positives = 377/894 (42%), Gaps = 74/894 (8%)
Query: 32 QEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGI-----RHVHPNGTLQIFPF 86
Q V S + + P +P T +YL G+ V + V TL + +
Sbjct: 416 QRVSSVSFSSIVPDAPKVTMPEKTPGYYLQPGQIPCSVDSLLPFTLSFVRNGVTLGVDQY 475
Query: 87 PPSSFS--------TLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMR- 137
S S TL + Y C A + +G R+Q V P ++V + T+
Sbjct: 476 LKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFF--DVSEPPPVIQVPNNVTVTP 533
Query: 138 GNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQ-NEDGLYNYR 196
G AV C+I S+V+ +T ++D V L +R + +L +K V+ N+ G Y
Sbjct: 534 GERAVLTCLIISAVDYNLTWQRNDRD-VRLAEPARIRTLANLSLELKSVKFNDAGEY--- 589
Query: 197 CITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDY 256
H S++A +F++ P + ++ G V + C A G+P+P
Sbjct: 590 ----HCMVSSEGGSSAASVFLT--VQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKI 643
Query: 257 RWLKDNMPLELSGRFQKTVTG-LLIENIRPSDSGSYVCEVSNRYGTAKVIGRL-YVKQPL 314
W ++M + S R++ T G L I+N P D+G Y C SN GT K L Y++ P
Sbjct: 644 AWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAP- 702
Query: 315 KATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDH 374
K + ++ ++G + C +G ++ W++ L P + I + I +
Sbjct: 703 KLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQET 762
Query: 375 MVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKI-ISAFSEKVVSPAEPVSLMCNVKGT 433
D G Y C + A ++ L+ G+P + I ++ + V+L C V+G
Sbjct: 763 Q-DLDAGDYTCVAINEAGRATG--KITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGY 819
Query: 434 PLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVV 493
P PTI W D+ + +S + + LN+ +S D G Y C A N G +
Sbjct: 820 PEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWAS---DKGTYICEAENQFGKI 876
Query: 494 LYQARINVRGPASIRPMKNIT-----AIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFN 547
+ + V G + P+ I+ I G+ + C ++ G P +W KNS +L
Sbjct: 877 QSETTVTVTG--LVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAML-LQ 933
Query: 548 HRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRF 607
+ + ++G+L + VQ + D GEYTC V + +++ V V V P IQ +
Sbjct: 934 NPYITVRSDGSLHIERVQLQ-DGGEYTC-VASNVAGTNNKTTSVVVHVLPTIQHGQQILS 991
Query: 608 SI-GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGN 666
+I G V +PC SG+ ++ W K G I S D SL + + +G
Sbjct: 992 TIEGIPVTLPCKA-SGNPKPSVIWSKKGELISTSSAKFSAGAD--GSLYVVSPGGEESGE 1048
Query: 667 YTCIARNEAAAVEHQSQLIVRVPPKFVVQPR--DQDG------IYGKAVILNCSAEGYPV 718
Y C A N A + + QL V V P+ R QD + G+ V L C + P
Sbjct: 1049 YVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPP 1108
Query: 719 PTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSK 778
P I W + + F P R L +GS+ I DSG YLC V+ ++ +V++
Sbjct: 1109 PIITWA-KETQLISPFSP-----RHTFLPSGSMKITETRTSDSGMYLC-VATNIAGNVTQ 1161
Query: 779 SMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVS 838
++ L V +P I P GQ+ ++ C A G ++ W K + LV
Sbjct: 1162 AVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTM-------LVD 1214
Query: 839 TKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIE 892
+ TL I D+G ++C A N G D I L VQEPP ++E
Sbjct: 1215 GEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLE 1268
Score = 216 bits (549), Expect = 2e-55
Identities = 217/874 (24%), Positives = 351/874 (40%), Gaps = 58/874 (6%)
Query: 30 SLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPS 89
SL V T + C + +PP + WY G I + + + L I S
Sbjct: 3065 SLSVVNVREGTSVSLECESNAVPPPVITWY-KNGRMITESTHVEILADGQMLHIKKAEVS 3123
Query: 90 SFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPS 149
Y C A N +G+ ++ H+ + P ++ +++ + ++ +
Sbjct: 3124 D------TGQYVCRAINVAGR-DDKNFHLNVYV--PPSIEGPEREVIVETISNPVTLTCD 3174
Query: 150 SVEAYITVVSWEKDTVSLVSGSRF---LITSTGALYIKDVQNEDGLYNYRCITRHRYTGE 206
+ ++W K+ + + +++ L I Q+ D NY CI + E
Sbjct: 3175 ATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDS-GNYTCIASNM---E 3230
Query: 207 TRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
+ L + P + A + + + G+ VEL C A G P P +WLKD P+
Sbjct: 3231 GKAQKYYFLSIQVPPSVAGAEIPS--DVSVLLGENVELVCNANGIPTPLIQWLKDGKPIA 3288
Query: 267 L--SGRFQKTVTG--LLIENIRPSDSGSYVCEVSNRYGTAKVIGRL--YVKQPLKATISP 320
+ R + + G L I SD+G Y C +N G I L YV ++
Sbjct: 3289 SGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDE 3348
Query: 321 -RKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSD 379
K+ + V + +++ C TGT +++W +NG L ++R+ I+ V SD
Sbjct: 3349 AEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQV-SD 3407
Query: 380 GGAYQCFV-RKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTI 438
Y C + + + Y V E V S+ C GTP P++
Sbjct: 3408 VAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSM 3467
Query: 439 TWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQAR 498
W D P+ G ++ +++ G V+ L ++ D G Y C A+N AG V
Sbjct: 3468 AWLRDGQPL--GLDAHLT--VSTHGMVLQLLK---AETEDSGKYTCIASNEAGEVSKHFI 3520
Query: 499 INVRGPASIRPMKN---ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFEN 555
+ V P I + I+ I + C G P + W K+ LP +
Sbjct: 3521 LKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGG 3580
Query: 556 NGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSI---GQR 612
L++S Q E D G YTC + P + V V VPP I + PR ++
Sbjct: 3581 GEVLRISTAQVE-DTGRYTC-LASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQ 3638
Query: 613 VFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIAR 672
V + C + P+ ITW ++G + + V I + L+I+N L NYTC+A
Sbjct: 3639 VTLECKSDAVPPPV-ITWLRNGERLQATPRVRI--LSGGRYLQINNADLGDTANYTCVAS 3695
Query: 673 NEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP 732
N A + L V VPP P+ + K+ +L C AEG P P I W+ GA +
Sbjct: 3696 NIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWR-KDGAVL- 3753
Query: 733 QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITS 792
+ R +L NG L I+ D+G YLC +N G D + + L V +P I
Sbjct: 3754 ----AGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTD-RRRIDLQVHVPPSIAP 3808
Query: 793 YPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQI 852
P + ++C A G + W K ++N + + G VI I
Sbjct: 3809 GPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVI----I 3864
Query: 853 LPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886
P+V +D+ + C N G+D+ + LTVQ PP
Sbjct: 3865 SPSV-DDTATYECTVTNGAGDDKRTVDLTVQVPP 3897
Score = 215 bits (548), Expect = 3e-55
Identities = 331/1434 (23%), Positives = 549/1434 (38%), Gaps = 223/1434 (15%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPG-IRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTA 104
C ++GIPP L W + D G +R + LQI S + Y C A
Sbjct: 2218 CESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQI------SIAEKSDAALYSCVA 2271
Query: 105 ENPSGKIRSQ---DVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWE 161
N +G + + V+I+ + + E T RG +C + +T W
Sbjct: 2272 SNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVT-RGKSISLECEVQGIPPPTVT---WM 2327
Query: 162 KDTVSLVSGSRFLITSTG-ALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDP 220
KD L+ I G L +K++ D Y C+ + G T + +
Sbjct: 2328 KDGHPLIKAKGVEILDEGHILQLKNIHVSD-TGRYVCVAVN-VAGMTDKKYDLSV----- 2380
Query: 221 ANSAPSILDGF---DHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG 277
++ PSI+ ++ + V L C+A G P P W KD P+ LS + G
Sbjct: 2381 -HAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGG 2439
Query: 278 LLIENIRPS--DSGSYVCEVSNRYGTAKVIGRLYVKQPL----KATISPRKVKSSVGSQV 331
++ ++ + D+G Y C V N G + I L V P + T+ KVK V
Sbjct: 2440 RMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEK--QSV 2497
Query: 332 SLSCSVTGTEDQELSWYRNGE---------ILNPGKNVRITGINHENLIMDHMVKSDGGA 382
+L+C VTG E++W+++G+ I++ G+ ++IT + + + S
Sbjct: 2498 TLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAG 2557
Query: 383 YQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTL 442
++ + + V DG P+ ++ P SL+C P TITW
Sbjct: 2558 HKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILN------SPTSLVCEAYSYPPATITWFK 2611
Query: 443 DDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR 502
D P+ + R I G + LN +Q + G Y C A N AG ++ + V
Sbjct: 2612 DGTPLESNRNIR----ILPGGRTLQILN---AQEDNAGRYSCVATNEAGEMIKHYEVKVY 2664
Query: 503 GPASIR---------PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAF 553
P I K + + C P S+ WYK+ L +
Sbjct: 2665 IPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIA 2724
Query: 554 ENNGTLKLSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVPPFIQPF-------- 602
N TL++ + Q D G YTC N+ + +L V ++VPP Q
Sbjct: 2725 ANGHTLQIKEAQIS-DTGRYTCVASNIAGEDEL----DFDVNIQVPPSFQKLWEIGNMLD 2779
Query: 603 -----EFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRIS 657
E I + + C + P T+TW KDG P+ S V I + L+I
Sbjct: 2780 TGRNGEAKDVIINNPISLYCETNAAP-PPTLTWYKDGHPLTSSDKVLI--LPGGRVLQIP 2836
Query: 658 NLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ------PRDQDGIYGKAVILNC 711
+ G YTC+A NEA Q + V VPP +++ P + + K+ ++ C
Sbjct: 2837 RAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPP--IIKGANSDLPEEVTVLVNKSALIEC 2894
Query: 712 SAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSN 770
+ G P P W+ QP+ + + LSNG +L I + D G Y+C N
Sbjct: 2895 LSSGSPAPRNSWQ-------KDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAEN 2947
Query: 771 DVGADVSKSMYLTVKIPAMITSYPNTTL-ATQGQKKEMSCTAHGEKPIIVRWEKEDRIIN 829
G+ K L V +P + + L ++C G P + W K ++ I
Sbjct: 2948 TAGS-AKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIK 3006
Query: 830 PEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP--- 886
+V TLQI+ D G ++C AIN GE + LTV PP
Sbjct: 3007 LNTNTLIVPGGR-------TLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIK 3059
Query: 887 --DPPEIEIKDVKART-ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLN 943
D + + +V+ T ++L IT Y KN +S Q+
Sbjct: 3060 DHDSESLSVVNVREGTSVSLECESNAVPPPVITWY----KNGRMITESTHVEILADGQML 3115
Query: 944 SATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSI-- 1001
++ + Y R A N G+ + + L + + +GP +EV +E IS+
Sbjct: 3116 HIKKAEVSDTGQYVCR--AINVAGRDDKNFHLNVYVPPSI-EGPEREVIVETISNPVTLT 3172
Query: 1002 ---------RVTWKAPKKHLQNG------IIRG---YQIGYREYSTGGNFQFNIISVDTS 1043
+ W K ++N I+ G QI ++S GN + I+ +
Sbjct: 3173 CDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGN--YTCIASNME 3230
Query: 1044 GDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAI--ATS 1101
G ++ Y Y L +Q + EI + DV ENV+ + A
Sbjct: 3231 GKAQKY----------YFLSIQ----VPPSVAGAEIPS----DVSVLLGENVELVCNANG 3272
Query: 1102 PESISISWSTLSKEALNGILQGFRV--------IYWANLMDGELGEIKNITTTQPSLELD 1153
+ I W K +G + RV IY A + + G+ + T E
Sbjct: 3273 IPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGA--LTSDTGKYTCVATNPAGEE-- 3328
Query: 1154 GLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLP-- 1211
++ N ++ V R G+ +E++ T + ++ A ++WL
Sbjct: 3329 --DRIFNLNVYVTPTIR-GNKDEAEKLMTLVDTSI-----NIECRATGTPPPQINWLKNG 3380
Query: 1212 -PLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLS--RNRQYSVWVVAVTSAG 1268
PL L+ IR + + ++ + ++ N + N+ Y++ V A +
Sbjct: 3381 LPLPLSSHIR---LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMD 3437
Query: 1269 RGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPS 1328
+E ITV G+ T+ + C G P+P++ W++D G P
Sbjct: 3438 NSMGTEEITV------------LKGSSTS-------MACITDGTPAPSMAWLRD--GQP- 3475
Query: 1329 LVTIDGRRSIFSNGSFIIRTVKA--EDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
+ +D ++ ++G +++ +KA EDSG Y+CIA+N G L+V PP
Sbjct: 3476 -LGLDAHLTVSTHG-MVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP 3527
Score = 214 bits (544), Expect = 9e-55
Identities = 323/1405 (22%), Positives = 534/1405 (38%), Gaps = 194/1405 (13%)
Query: 46 CPAAGIPPVTLRWY-----LATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTY 100
C PP TL WY L + +++ +PG R + P + Y
Sbjct: 2799 CETNAAPPPTLTWYKDGHPLTSSDKVLILPGGR---------VLQIPRAKVEDA---GRY 2846
Query: 101 YCTAENPSGKIRSQ---DVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITV 157
C A N +G+ Q V + +++ + E+ + A+ +C+ S
Sbjct: 2847 TCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRN-- 2904
Query: 158 VSWEKDTVSLVSGSRFLITSTGA-LYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLF 216
SW+KD L+ S G L I + Q D + Y C+ + + SA+ +
Sbjct: 2905 -SWQKDGQPLLEDDHHKFLSNGRILQILNTQITD-IGRYVCVAENT-------AGSAKKY 2955
Query: 217 VSDPANSAPSILDG-FDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV 275
+ + PS++ ++ + + L C+ G P PD WLK+ P++L+
Sbjct: 2956 FNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVP 3015
Query: 276 TGLLIENIRP--SDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSV----GS 329
G ++ IR SD G Y C N+ G +K L V P + S V G+
Sbjct: 3016 GGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGT 3075
Query: 330 QVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK 389
VSL C ++WY+NG ++ +V I + + L + SD G Y C R
Sbjct: 3076 SVSLECESNAVPPPVITWYKNGRMITESTHVEILA-DGQMLHIKKAEVSDTGQYVC--RA 3132
Query: 390 DKLSAQDYVQVVLEDGTPKIISAFSEKVV--SPAEPVSLMCNVKGTPLPTITWTLDDDPI 447
++ +D L P I +V+ + + PV+L C+ G P PTI W + I
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRI 3192
Query: 448 LKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI 507
S + I S G S L I+ SQ D G Y C A+N G ++++ P S+
Sbjct: 3193 ENSDSLEVR--ILSGG---SKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSV 3247
Query: 508 RPMK---NITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNH--RQVAFENNGTLKLS 562
+ +++ + G + + C G P I+W K+ + R N TL +
Sbjct: 3248 AGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIY 3307
Query: 563 DVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQ----PFEFPRFSIGQRVFIPCV 618
D G+YTC V P + ++ V V P I+ E + + I C
Sbjct: 3308 GALTS-DTGKYTC-VATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECR 3365
Query: 619 VVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAV 678
+G P I W K+G P+P S + + + +RI + YTC+A N A
Sbjct: 3366 A-TGTPPPQINWLKNGLPLPLSSHIRL--LAAGQVIRIVRAQVSDVAVYTCVASNRAGVD 3422
Query: 679 EHQSQLIVRVPPKF--VVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQP 736
L V PP + + + G + + C +G P P++ W + QP
Sbjct: 3423 NKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAW-------LRDGQP 3475
Query: 737 IALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPN 795
+ L+ + V ++G +L + EDSG Y C SN+ G +VSK L V P I
Sbjct: 3476 LGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAG-EVSKHFILKVLEPPHINGSEE 3534
Query: 796 --TTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEV-ISTLQI 852
E++C A G + W K+ R + P+ + V T GE + IST Q+
Sbjct: 3535 HEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPL-PQTDQ--VQTLGGGEVLRISTAQV 3591
Query: 853 LPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGN 912
ED+G ++C A + G+D + V P P I D LR N
Sbjct: 3592 -----EDTGRYTCLASSPAGDDDKEYLVRVHVP---PNIAGTDEPRDITVLR-------N 3636
Query: 913 SPITGYDIECKNKS------------DSWDSAQRTKDVSP----QLNSATIIDIHPSSTY 956
+T +ECK+ + + + R + +S Q+N+A + D T
Sbjct: 3637 RQVT---LECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGD-----TA 3688
Query: 957 SIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISS---------QSIRVTWKA 1007
+ A N GK+ LT+ GP V L S+ + R+TW+
Sbjct: 3689 NYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRK 3748
Query: 1008 PKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQAC 1067
++ G + YS N +I S + D+ Y + A
Sbjct: 3749 -----DGAVLAG---NHARYSILENGFLHIQSAHVT-DTGRY-------------LCMAT 3786
Query: 1068 NRAGTGPSSQEIITTTLEDVPSYPP--ENVQAIATSPESISISWSTLSKEALNGILQGFR 1125
N AGT + I + PS P N+ I +++ + + K ++N G
Sbjct: 3787 NAAGT---DRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHL 3843
Query: 1126 VIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTK 1185
+ N L ++ PS++ + + AGD R+ + +
Sbjct: 3844 LNVDQNQNSYRLLSSGSLVIISPSVD-------DTATYECTVTNGAGDDKRTVDLTVQVP 3896
Query: 1186 EDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVI---SEFEASPD 1242
+ P + +++ + +G+ P+P++ + P
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCT------ASGV----------PFPSIHWTKNGIRLLPR 3940
Query: 1243 SFSYRIPN------LSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVT 1296
YRI + L+ ++ V G++ +T+ P I +
Sbjct: 3941 GDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLH--VHEPPVIQPQPSELH 3998
Query: 1297 TPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRR-SIFSNGSFIIRTVKAEDSG 1355
I+LPC+A G PSP + W K+ V GR ++ +G I ED+G
Sbjct: 3999 VILNNPILLPCEATGTPSPFITWQKEGIN----VNTSGRNHAVLPSGGLQISRAVREDAG 4054
Query: 1356 YYSCIANNNWGSDEIILNLQVQVPP 1380
Y C+A N G+ + L VQVPP
Sbjct: 4055 TYMCVAQNPAGTALGKIKLNVQVPP 4079
Score = 206 bits (525), Expect = 1e-52
Identities = 199/814 (24%), Positives = 338/814 (41%), Gaps = 73/814 (8%)
Query: 100 YYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAY----- 154
Y CT N +GK Q IK + P +++ GNV ++ +S+
Sbjct: 1523 YQCTVSNAAGK---QAKDIKLTIYIPPSIK-------GGNVTTDISVLINSLIKLECETR 1572
Query: 155 ---ITVVSWEKDTVSLVSGSRFLITSTGA-LYIKDVQNEDGLYNYRCITRHRYTGETRQS 210
+ ++W KD ++S S+ L G L+I Q D Y C + G +S
Sbjct: 1573 GLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSA-TYTCHVAN-VAGTAEKS 1630
Query: 211 NSARLFVSDPANSAPSILDGFD----HRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
++V P +++G +++ + + L CKA G+P P WLKD +P++
Sbjct: 1631 FHVDVYV-------PPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVK 1683
Query: 267 LSGRFQKTVTGLLIE--NIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQP--LKATISPRK 322
+ + G +E + + D G Y+C ++ G ++ + V P ++
Sbjct: 1684 ANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSY 1743
Query: 323 VKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGA 382
V + + L C VTG+ + W ++G++++ +I +N L++ S+ G
Sbjct: 1744 FIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKIL-LNGRKLVIAQAQVSNTGL 1802
Query: 383 YQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTL 442
Y+C + +V + S SE+VV +PV+L C G P P+ITW
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLK 1862
Query: 443 DDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVR 502
DD P+ + + + I S G V L I+ + + D G Y C A N+AG +++V
Sbjct: 1863 DDQPV---NTAQGNLKIQSSGRV---LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVH 1916
Query: 503 GPASIRP---MKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTL 559
P S+ M N T + + C+ G P I WYK++ LL + F N G +
Sbjct: 1917 EPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS-GSTSMTFLNRGQI 1975
Query: 560 KLSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIP 616
+ + D G Y C N +L S VHV P + V +
Sbjct: 1976 IDIESAQISDAGIYKCVAINSAGATELFYSLQVHVA---PSISGSNNMVAVVVNNPVRLE 2032
Query: 617 CVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAA 676
C P ++TW KDG P+ S + + L +++ + G YTC+A N A
Sbjct: 2033 CEARGIPAP-SLTWLKDGSPV-SSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAG 2090
Query: 677 AVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQP 736
+ L V VPP + + ++ + +AV L C ++ P PT+ W + P
Sbjct: 2091 EKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTW-------LKDGHP 2143
Query: 737 IALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPN 795
+ + + N S+L I+ +D+G Y C+ +N V K+ + + +P I
Sbjct: 2144 LLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATN-VAGKTEKNYNVNIWVPPNIGGSDE 2202
Query: 796 TTLAT--QGQKKEMSCTAHGEKPIIVRWEKE-DRIINPEMARYLVSTKEVGEEVISTLQI 852
T T +G + C + G P + W+K+ ++ M R V G + LQI
Sbjct: 2203 LTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGR--VRILSGGRQ----LQI 2256
Query: 853 LPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886
+ D+ +SC A N G + L V P
Sbjct: 2257 SIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRP 2290
Score = 201 bits (512), Expect = 5e-51
Identities = 328/1407 (23%), Positives = 535/1407 (38%), Gaps = 193/1407 (13%)
Query: 45 PCPAAGIPPVTLRWYLATGEEIYD-VPGIRHVHPNGTLQIFPFPPSSFSTLIHDN-TYYC 102
PCPA G P T++W L G E+ PGI + +GTL + S +DN Y C
Sbjct: 1287 PCPAKGTPKPTIKW-LHNGRELTGREPGIS-ILEDGTLLVIA------SVTPYDNGEYIC 1338
Query: 103 TAENPSGKIRSQ---DVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
A N +G + VH+ V+++ +V + + + C + + ++
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKE--QVTNVSVLLNQLTNLFCEVEGTPSP---IIM 1393
Query: 160 WEKDTVSLVSGSRFLITSTGALY--IKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFV 217
W KD V + S + G + + + G Y+ + I S + F
Sbjct: 1394 WYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINI--------AGTSQKYFN 1445
Query: 218 SDPANSAPSILDGFDHRKAMAGQR-VELPCKALGHPEPDYRWLKDNMPL-------ELSG 269
D I F + ++ R V L C+ G P PD W KD PL EL
Sbjct: 1446 IDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLD 1505
Query: 270 RFQKTVTGLLIENIRPSDSGSYVCEVSNRYGT-AKVIG-RLYVKQPLKATISPRKVKSSV 327
R Q L ++N R +D G Y C VSN G AK I +Y+ +K + +
Sbjct: 1506 RGQV----LHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLI 1561
Query: 328 GSQVSLSCSVTGTEDQELSWYRNGE-ILNPGKNVRITGINHENLIMDHMVKSDGGAYQCF 386
S + L C G ++WY++G+ I++ + + I + L + SD Y C
Sbjct: 1562 NSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYID--KGQYLHIPRAQVSDSATYTCH 1619
Query: 387 VRKDKLSAQD--YVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDD 444
V +A+ +V V + ++ K V A ++L C G P P +TW D
Sbjct: 1620 VANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDG 1679
Query: 445 DPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGP 504
P+ + RI G L I S+Q D G Y C A + AG + ++V P
Sbjct: 1680 VPVKANDNIRIEA-----GG--KKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVP 1732
Query: 505 ASIR---PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL 561
+I + + C V G P +I W K+ L+ N L +
Sbjct: 1733 PAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVI 1792
Query: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVS 621
+ Q + G Y C + + VTV VPP I+ + + + ++
Sbjct: 1793 AQAQVS-NTGLYRC-MAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIA 1850
Query: 622 GDLPI-TITWQKDGRPIPGSLGVTIDNIDFTSS---LRISNLSLMHNGNYTCIARNEAAA 677
+P +ITW KD +P+ + G N+ SS L+I+ L G YTC+A N A
Sbjct: 1851 NGIPNPSITWLKDDQPVNTAQG----NLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGE 1906
Query: 678 VEHQSQLIVRVPPKFVVQPR--DQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQ 735
+ QL V PP + ++ + V L C A G PVP I W +
Sbjct: 1907 TQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDN-------R 1959
Query: 736 PIALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMY-LTVKIPAMITSY 793
++ + + L+ G ++ I+ D+G Y C N GA ++ Y L V + I+
Sbjct: 1960 LLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGA--TELFYSLQVHVAPSISGS 2017
Query: 794 PNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQIL 853
N + C A G + W K+ +P VS+ G +V+S +IL
Sbjct: 2018 NNMVAVVVNNPVRLECEARGIPAPSLTWLKDG---SP------VSSFSNGLQVLSGGRIL 2068
Query: 854 PTVR---EDSGFFSCHAINSYGEDRGIIQLTVQEPPD--PPEIEIKDVKARTI------- 901
D+G ++C A+N+ GE + I L V PP+ E + + ++ +
Sbjct: 2069 ALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSD 2128
Query: 902 -----TLRWTMGFDGNSPI--TGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSS 954
TL W DG+ + G I +N+S + +D AT +
Sbjct: 2129 AIPPPTLTWLK--DGHPLLKKPGLSIS-ENRSVLKIEDAQVQDTGRYTCEATNVAGKTEK 2185
Query: 955 TYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQN 1014
Y++ ++ IG S+ +LT+ +G + E + WK KK +
Sbjct: 2186 NYNVNIWVPPNIGGSDELTQLTVI------EGNLISLLCESSGIPPPNLIWK--KK--GS 2235
Query: 1015 GIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGP 1074
++ R S G Q IS+ D+ +Y+ A N AGT
Sbjct: 2236 PVLTDSMGRVRILSGGRQLQ---ISIAEKSDAALYS-------------CVASNVAGTAK 2279
Query: 1075 SS---QEIITTTLEDVPSYPPENVQAIATSPESISISWST--LSKEALNGILQGFRVIYW 1129
Q I T+ + S+P E I T +SIS+ + + + G +I
Sbjct: 2280 KEYNLQVYIRPTITNSGSHPTE---IIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKA 2336
Query: 1130 AN---LMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKE 1186
L +G + ++KNI + +Y ++ V T +
Sbjct: 2337 KGVEILDEGHILQLKNIHVSDTG-------RYVCVAVNVAGMTD-----------KKYDL 2378
Query: 1187 DVPGPPA--GVKAAAASASMVFVSWLP-PLKLNGIIRKYTVFCSHPYPTVISEFEASPDS 1243
V PP+ G + + S+V + + + +GI P P++ + P S
Sbjct: 2379 SVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGI----------PLPSITWFKDGWPVS 2428
Query: 1244 FSYRIPNLSRNRQYSVWVVAVTSAGR---------GNSSEIITVEPLAKAPARILTFSGT 1294
S + LS R + + AG+ G +I + L
Sbjct: 2429 LSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLED 2488
Query: 1295 VTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI-IRTVKAED 1353
V + + L C+ G+P P + W KD G P + D I S G F+ I V+
Sbjct: 2489 VKVKEKQSVTLTCEVTGNPVPEITWHKD--GQP--LQEDEAHHIISGGRFLQITNVQVPH 2544
Query: 1354 SGYYSCIANNNWGSDEIILNLQVQVPP 1380
+G Y+C+A++ G +L V V P
Sbjct: 2545 TGRYTCLASSPAGHKSRSFSLNVFVSP 2571
Score = 199 bits (507), Expect = 2e-50
Identities = 206/763 (26%), Positives = 319/763 (41%), Gaps = 73/763 (9%)
Query: 158 VSWEKDTVSLVSGSRFLITSTGA--LYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARL 215
++W KD + S S L +G L + Q D Y C+ + GE ++ R+
Sbjct: 2043 LTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISD-TGRYTCVAVNA-AGEKQRDIDLRV 2100
Query: 216 FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPL----ELSGRF 271
+V P+I+ + + Q VEL C++ P P WLKD PL LS
Sbjct: 2101 YVP------PNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISE 2154
Query: 272 QKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSV--GS 329
++V L IE+ + D+G Y CE +N G + + + P S + +V G+
Sbjct: 2155 NRSV--LKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGN 2212
Query: 330 QVSLSCSVTGTEDQELSWYRNGE--ILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFV 387
+SL C +G L W + G + + VRI + L + KSD Y C
Sbjct: 2213 LISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQ-LQISIAEKSDAALYSCVA 2271
Query: 388 RKDKLSAQ-DY-VQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDD 445
+A+ +Y +QV + S +E +V+ + +SL C V+G P PT+TW D
Sbjct: 2272 SNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGH 2331
Query: 446 PILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPA 505
P++K I EG+++ NI V D G Y C A N AG+ + ++V P
Sbjct: 2332 PLIKAKGVE----ILDEGHILQLKNI---HVSDTGRYVCVAVNVAGMTDKKYDLSVHAPP 2384
Query: 506 SI----RPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL 561
SI R +NI+ + + C G P SI W+K+ + ++ L+L
Sbjct: 2385 SIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRL 2444
Query: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVH-VTVKVPPFI---QPFEFPRFSIGQRVFIPC 617
E D G+YTC +V+ + + ++V VPP I E + Q V + C
Sbjct: 2445 MQTTME-DAGQYTC--VVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTC 2501
Query: 618 VVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAA 677
V +P ITW KDG+P+ I I L+I+N+ + H G YTC+A + A
Sbjct: 2502 EVTGNPVP-EITWHKDGQPLQEDEAHHI--ISGGRFLQITNVQVPHTGRYTCLASSPAGH 2558
Query: 678 VEHQSQLIVRVPPKFV-----VQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP 732
L V V P P D I L C A YP TI W F G
Sbjct: 2559 KSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITW-FKDGT--- 2614
Query: 733 QFQPIALNGRIQVLSNG-SLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMIT 791
P+ N I++L G +L I + E+++G Y C +N+ G ++ K + V IP +I
Sbjct: 2615 ---PLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG-EMIKHYEVKVYIPPIIN 2670
Query: 792 S--------YPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVG 843
P + C A+ + W K+ + + + + +
Sbjct: 2671 KGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH-- 2728
Query: 844 EEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886
TLQI D+G ++C A N GED + +Q PP
Sbjct: 2729 -----TLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPP 2766
Score = 197 bits (500), Expect = 1e-49
Identities = 224/931 (24%), Positives = 360/931 (38%), Gaps = 141/931 (15%)
Query: 33 EVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFS 92
E++ + C GIPP T+ W + G + G+ + LQ+ S
Sbjct: 2301 EIIVTRGKSISLECEVQGIPPPTVTW-MKDGHPLIKAKGVEILDEGHILQLKNIHVSD-- 2357
Query: 93 TLIHDNTYYCTAENPSG---KIRSQDVHIKAVL----REPYTVRVEDQKTMRGNVAVFKC 145
Y C A N +G K VH + R P + V ++ ++
Sbjct: 2358 ----TGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGI 2413
Query: 146 IIPSSVEAYITVVSWEKD--TVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRY 203
+PS ++W KD VSL + R L ++ + G Y C+ R+
Sbjct: 2414 PLPS--------ITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAG--QYTCVVRNA- 2462
Query: 204 TGETRQSNSARLFVSDPANSAPSIL--DGFDHRKAMAGQRVELPCKALGHPEPDYRWLKD 261
GE R+ + V P I+ + + K Q V L C+ G+P P+ W KD
Sbjct: 2463 AGEERKIFGLSVLV------PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKD 2516
Query: 262 NMPLE--------LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYV-KQ 312
PL+ GRF L I N++ +G Y C S+ G L V
Sbjct: 2517 GQPLQEDEAHHIISGGRF------LQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVS 2570
Query: 313 PLKATI----SPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHE 368
P A + +P V + S SL C ++W+++G L +N+RI
Sbjct: 2571 PTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRT 2630
Query: 369 NLIMDHMVKSDGGAYQCFVRKD------KLSAQDYVQVVLEDG-------TPKIISAFSE 415
I++ + + G Y C + + Y+ ++ G +PK E
Sbjct: 2631 LQILNAQ-EDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPK------E 2683
Query: 416 KVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQ 475
+ ++L C P +++W D P LK H I + G+ L I +Q
Sbjct: 2684 VKIKVNNTLTLECEAYAIPSASLSWYKDGQP-LKSDDH---VNIAANGHT---LQIKEAQ 2736
Query: 476 VRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNI-------------TAIAGRDTY 522
+ D G Y C A+N AG +N++ P S + + I I
Sbjct: 2737 ISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPIS 2796
Query: 523 IHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQ 582
++C P ++ WYK+ + L + + + L++ + E D G YTC V V
Sbjct: 2797 LYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVE-DAGRYTC-VAVNEA 2854
Query: 583 LSTSQSVHVTVKVPPFIQPF-----EFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPI 637
S V V VPP I+ E + + I C+ P +WQKDG+P+
Sbjct: 2855 GEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRN-SWQKDGQPL 2913
Query: 638 PGSLGVTIDNIDFTSS---LRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVV 694
+ D+ F S+ L+I N + G Y C+A N A + + L V VPP V+
Sbjct: 2914 -----LEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPS-VI 2967
Query: 695 QPRDQD--GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG-SL 751
P+ ++ + + L C G+P P + W + QPI LN ++ G +L
Sbjct: 2968 GPKSENLTVVVNNFISLTCEVSGFPPPDLSW-------LKNEQPIKLNTNTLIVPGGRTL 3020
Query: 752 LIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLAT----QGQKKEM 807
I D G Y C N G + K LTV +P I + + +L+ +G +
Sbjct: 3021 QIIRAKVSDGGEYTCIAINQAG-ESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSL 3079
Query: 808 SCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVR---EDSGFFS 864
C ++ P ++ W K R+I T+ E+++ Q+L + D+G +
Sbjct: 3080 ECESNAVPPPVITWYKNGRMI----------TESTHVEILADGQMLHIKKAEVSDTGQYV 3129
Query: 865 CHAINSYGEDRGIIQLTVQEPP--DPPEIEI 893
C AIN G D L V PP + PE E+
Sbjct: 3130 CRAINVAGRDDKNFHLNVYVPPSIEGPEREV 3160
Score = 196 bits (497), Expect = 3e-49
Identities = 208/882 (23%), Positives = 357/882 (40%), Gaps = 94/882 (10%)
Query: 44 VPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCT 103
+PC A+G P ++ W GE I +G+L + P S Y CT
Sbjct: 1000 LPCKASGNPKPSVIWS-KKGELISTSSAKFSAGADGSLYVVS-PGGEES-----GEYVCT 1052
Query: 104 AENPSGKIRSQ---DVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYIT-VVS 159
A N +G + + V+++ + +D+ +A + +P V++ +++
Sbjct: 1053 ATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIIT 1112
Query: 160 WEKDTVSLVS--GSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFV 217
W K+T L+S R +G++ I + + D Y C+ + G Q+ + V
Sbjct: 1113 WAKET-QLISPFSPRHTFLPSGSMKITETRTSDSGM-YLCVATN-IAGNVTQAVKLNVHV 1169
Query: 218 SDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTG 277
P I G H K GQRV++PC A G P P W K + + G +
Sbjct: 1170 P------PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPD 1223
Query: 278 --LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQP-----LKATISPRKVKSSVGSQ 330
L I+ PSD+G Y C +N GT + L+V++P L+ + + +
Sbjct: 1224 GTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQR 1283
Query: 331 VSLSCSVTGTEDQELSWYRNGEILN---PGKNVRITGINHENLIMDHMVKSDGGAYQCFV 387
+ C GT + W NG L PG ++ G L++ + D G Y C
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTL---LVIASVTPYDNGEYICVA 1340
Query: 388 RKD------KLSAQDYVQVVLEDGTPKIISAFSEKVVSPA----EPVSLMCNVKGTPLPT 437
+ K + + +V V++D E+V + + + +L C V+GTP P
Sbjct: 1341 VNEAGTTERKYNLKVHVPPVIKD---------KEQVTNVSVLLNQLTNLFCEVEGTPSPI 1391
Query: 438 ITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQA 497
I W D+ + + + + + G + L + + D G Y C A N AG
Sbjct: 1392 IMWYKDNVQVTESSTIQT----VNNGKI---LKLFRATPEDAGRYSCKAINIAGTSQKYF 1444
Query: 498 RINVRGPASIRPMK---NITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFE 554
I+V P +I ++ + RD + C+V G P+ I W+K+ L V
Sbjct: 1445 NIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELL 1504
Query: 555 NNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFP---RFSIGQ 611
+ G + + D+G Y C V ++ + +T+ +PP I+ I
Sbjct: 1505 DRGQVLHLKNARRNDKGRYQCTV-SNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINS 1563
Query: 612 RVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIA 671
+ + C +P ITW KDG+PI S ID L I + + YTC
Sbjct: 1564 LIKLECETRGLPMP-AITWYKDGQPIMSSSQALY--IDKGQYLHIPRAQVSDSATYTCHV 1620
Query: 672 RNEAAAVEHQSQLIVRVPPKF---VVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKG 728
N A E + V VPP + P ++ + ++ L C A G P P + W
Sbjct: 1621 ANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTW----- 1675
Query: 729 AGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP 787
+ P+ N I++ + G L I E D G Y+C V+ V + + V +P
Sbjct: 1676 --LKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYIC-VATSVAGEKEIKYEVDVLVP 1732
Query: 788 AMITSYPNTT--LATQGQKKEMSCTAHGEKPIIVRWEKEDRIINP-EMARYLVSTKEVGE 844
I T+ + E+ C G P + W K+ ++I+ + + L++ +++
Sbjct: 1733 PAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKL-- 1790
Query: 845 EVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886
VI+ Q+ ++G + C A N+ G+ + ++TV PP
Sbjct: 1791 -VIAQAQV-----SNTGLYRCMAANTAGDHKKEFEVTVHVPP 1826
Score = 191 bits (486), Expect = 5e-48
Identities = 229/893 (25%), Positives = 342/893 (38%), Gaps = 81/893 (9%)
Query: 30 SLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPS 89
S +EV + C A IP +L WY G+ + + TLQI
Sbjct: 2680 SPKEVKIKVNNTLTLECEAYAIPSASLSWY-KDGQPLKSDDHVNIAANGHTLQI------ 2732
Query: 90 SFSTLIHDNTYYCTAENPSGKIRSQ-DVHIKAVLREPYTVRVEDQKTMRGNVAVFKCIIP 148
+ + Y C A N +G+ DV+I+ + + N II
Sbjct: 2733 KEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIIN 2792
Query: 149 SSVEAYI-------TVVSWEKDTVSLVSGSRFLITSTG-ALYIKDVQNEDGLYNYRCITR 200
+ + Y ++W KD L S + LI G L I + ED Y C+
Sbjct: 2793 NPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDA-GRYTCVAV 2851
Query: 201 HRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLK 260
+ GE R+ V A S L + + + + C + G P P W K
Sbjct: 2852 NE-AGEDSLQYDVRVLVPPIIKGANSDLP--EEVTVLVNKSALIECLSSGSPAPRNSWQK 2908
Query: 261 DNMPLELSGRFQKTVTGLLIE--NIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATI 318
D PL + G +++ N + +D G YVC N G+AK L V P + I
Sbjct: 2909 DGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVP-PSVI 2967
Query: 319 SPRKVKSS--VGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMV 376
P+ + V + +SL+C V+G +LSW +N + + N I I+ V
Sbjct: 2968 GPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKV 3027
Query: 377 KSDGGAYQCFV------RKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNV 430
SDGG Y C K K S YV ++D + +S + V VSL C
Sbjct: 3028 -SDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVN---VREGTSVSLECES 3083
Query: 431 KGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVV-----SYLNISSSQVRDGGVYRCT 485
P P ITW ++ +MIT +V L+I ++V D G Y C
Sbjct: 3084 NAVPPPVITW------------YKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCR 3131
Query: 486 ANNSAGVVLYQARINVRGPASIRPMKN--ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNL 543
A N AG +NV P SI + I + C G P +I W KN
Sbjct: 3132 AINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKR 3191
Query: 544 LPFNHRQVAFENNGTLKLSDVQKE-VDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPF 602
+ + +G KL + + D G YTC + + + ++++VPP +
Sbjct: 3192 IENSDSLEVRILSGGSKLQIARSQHSDSGNYTC-IASNMEGKAQKYYFLSIQVPPSVAGA 3250
Query: 603 EFP---RFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNL 659
E P +G+ V + C P+ I W KDG+PI I S+L I
Sbjct: 3251 EIPSDVSVLLGENVELVCNANGIPTPL-IQWLKDGKPIASGETERIRVSANGSTLNIYGA 3309
Query: 660 SLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQD---GIYGKAVILNCSAEGY 716
G YTC+A N A + L V V P + + + ++ + C A G
Sbjct: 3310 LTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGT 3369
Query: 717 PVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGAD 775
P P I W + P+ L+ I++L+ G ++ I D Y C SN G D
Sbjct: 3370 PPPQINW-------LKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVD 3422
Query: 776 VSKSMYLTVKIPAMITSYPNTTLAT--QGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMA 833
+K L V P + + T T +G M+C G + W ++ + + + A
Sbjct: 3423 -NKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLD-A 3480
Query: 834 RYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886
VST + LQ+L EDSG ++C A N GE L V EPP
Sbjct: 3481 HLTVSTHGM------VLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP 3527
Score = 185 bits (469), Expect = 4e-46
Identities = 225/926 (24%), Positives = 353/926 (38%), Gaps = 103/926 (11%)
Query: 16 FSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHV 75
F +H ++ L E V + C A GIP ++ W L + + G +
Sbjct: 1818 FEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITW-LKDDQPVNTAQGNLKI 1876
Query: 76 HPNG-TLQIFPFPPSSFSTLIHD-NTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQ 133
+G LQI TL+ D Y C A N +G+ + HI+ + EP + +ED
Sbjct: 1877 QSSGRVLQI-------AKTLLEDAGRYTCVATNAAGETQQ---HIQLHVHEPPS--LEDA 1924
Query: 134 KTMRGNVAVFKCIIPSSVEAY---ITVVSWEKDTVSLVSGSRFLITSTGALY-IKDVQNE 189
M + + +A + V++W KD L + + G + I+ Q
Sbjct: 1925 GKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQIS 1984
Query: 190 D-GLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKA 248
D G+ Y+C+ + + LF S + APSI + + V L C+A
Sbjct: 1985 DAGI--YKCVA-------INSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEA 2035
Query: 249 LGHPEPDYRWLKDNMPLELSGRFQKTVTG---LLIENIRPSDSGSYVCEVSNRYGTAKVI 305
G P P WLKD P+ + ++G L + + + SD+G Y C N G +
Sbjct: 2036 RGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRD 2095
Query: 306 GRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEIL--NPGKNVRIT 363
L V P + V + V L C L+W ++G L PG ++
Sbjct: 2096 IDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSI--- 2152
Query: 364 GINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISA---FSEKVVSP 420
N L ++ D G Y C ++ + + P I ++ V
Sbjct: 2153 SENRSVLKIEDAQVQDTGRYTC--EATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIE 2210
Query: 421 AEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGG 480
+SL+C G P P + W P+L R+ I S G L IS ++ D
Sbjct: 2211 GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRV--RILSGGR---QLQISIAEKSDAA 2265
Query: 481 VYRCTANNSAGVVLYQARINVRGPASIRPM--------KNITAIAGRDTYIHCRVIGYPY 532
+Y C A+N AG + + V IRP I G+ + C V G P
Sbjct: 2266 LYSCVASNVAGTAKKEYNLQV----YIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPP 2321
Query: 533 YSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVT 592
++ W K+ + L + L+L ++ D G Y C V V T + ++
Sbjct: 2322 PTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVS-DTGRYVC-VAVNVAGMTDKKYDLS 2379
Query: 593 VKVPP-FIQPFEFP-RFSIGQRVFIPCVVVSGDLPI-TITWQKDGRPIPGSLGVTIDNID 649
V PP I P S+ ++ + + +P+ +ITW KDG P+ SL ++ +
Sbjct: 2380 VHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPV--SLSNSVRILS 2437
Query: 650 FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIY--GKAV 707
LR+ ++ G YTC+ RN A L V VPP V + +D ++V
Sbjct: 2438 GGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSV 2497
Query: 708 ILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYYLC 766
L C G PVP I W QP+ + ++S G L I +V +G Y C
Sbjct: 2498 TLTCEVTGNPVPEITWH-------KDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTC 2550
Query: 767 KVSNDVGADVSKSMYLTVKIPAMITSY-----PNTTLATQGQKKEMSCTAHGEKPIIVRW 821
S+ G S+S L V + I P + C A+ P + W
Sbjct: 2551 LASSPAG-HKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITW 2609
Query: 822 EKEDRIINPEM-ARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQL 880
K+ + R L + TLQIL +++G +SC A N GE ++
Sbjct: 2610 FKDGTPLESNRNIRILPGGR--------TLQILNAQEDNAGRYSCVATNEAGEMIKHYEV 2661
Query: 881 TVQEPP------------DPPEIEIK 894
V PP P E++IK
Sbjct: 2662 KVYIPPIINKGDLWGPGLSPKEVKIK 2687
Score = 182 bits (463), Expect = 2e-45
Identities = 210/817 (25%), Positives = 339/817 (41%), Gaps = 76/817 (9%)
Query: 100 YYCTAENPSGKIRSQDVHIKAVLREP--YTVRVEDQKTMRGNVAVFKCIIPSSVEAYITV 157
Y+C + G S + ++EP TV ++Q G+ C S+
Sbjct: 589 YHCMVSSEGG---SSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMC---SATGYPKPK 642
Query: 158 VSWEKDTVSLVSGSRFLITSTGALYIKDVQNED-GLYNYRCITRHRYTGETRQSNSARLF 216
++W + + +V R+ +TS G L+IK+ +D G+Y C+ + G +Q+++ R
Sbjct: 643 IAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYG--CLASNS-AGTDKQNSTLRYI 699
Query: 217 VSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSG-RFQKTV 275
AP ++ G + CK G P P +W K ++ L S +
Sbjct: 700 ------EAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPL 753
Query: 276 TGLL-IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLS 334
GLL I+ + D+G Y C N G A L V P P V +GS V+L
Sbjct: 754 LGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLP 813
Query: 335 CSVTGTEDQELSWYR--NGEILN-PGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDK 391
C V G + + W R N I + P I+ + L + ++ SD G Y C
Sbjct: 814 CYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQF 873
Query: 392 LSAQDYVQVVLEDGTPKIISAF-SEKVVSPAEPVSLMCNV-KGTPLPTITWTLDDDPILK 449
Q V + +I S V + ++L C + G P+P W + +L+
Sbjct: 874 GKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQ 933
Query: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRP 509
+ S+G+ L+I Q++DGG Y C A+N AG + V +I+
Sbjct: 934 NPYITVR----SDGS----LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQH 985
Query: 510 MKNI-TAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568
+ I + I G + C+ G P S+ W K L+ + + + +G+L + E
Sbjct: 986 GQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGE- 1044
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTVKVPPFI----------QPFEFPRFSIGQRVFIPCV 618
+ GEY C + + V +TV V P + +P E + G+ V +PC
Sbjct: 1045 ESGEYVCTATNTAGYA-KRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLA-GEEVTLPCE 1102
Query: 619 VVSGDLPITITWQKDGRPI-PGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAA 677
V S PI ITW K+ + I P S T + S++I+ +G Y C+A N A
Sbjct: 1103 VKSLPPPI-ITWAKETQLISPFSPRHTFLP---SGSMKITETRTSDSGMYLCVATNIAGN 1158
Query: 678 VEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPI 737
V +L V VPPK P+ G+ V + C+A+G P+P I W SKG +
Sbjct: 1159 VTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITW--SKGGST-----M 1211
Query: 738 ALNGRIQVLS-NGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYP-- 794
++G V + +G+L I D+G Y C +N G D ++ + P + P
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPY 1271
Query: 795 NTTLATQ--GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVI--STL 850
NTT + Q+ E C A G ++W R + + +E G ++ TL
Sbjct: 1272 NTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGREL---------TGREPGISILEDGTL 1322
Query: 851 QILPTVRE-DSGFFSCHAINSYGEDRGIIQLTVQEPP 886
++ +V D+G + C A+N G L V PP
Sbjct: 1323 LVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP 1359
Score = 178 bits (452), Expect = 4e-44
Identities = 216/886 (24%), Positives = 342/886 (38%), Gaps = 81/886 (9%)
Query: 32 QEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSF 91
+EV L+ C ++G P W G+ + + + + LQI
Sbjct: 2880 EEVTVLVNKSALIECLSSGSPAPRNSWQ-KDGQPLLEDDHHKFLSNGRILQIL------- 2931
Query: 92 STLIHD-NTYYCTAENPSGKIRSQ---DVHIKAVLREPYTVRVEDQKTMRGNVAVFKCII 147
+T I D Y C AEN +G + +VH+ + P + E+ + N C +
Sbjct: 2932 NTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGP---KSENLTVVVNNFISLTCEV 2988
Query: 148 PSSVEAYITVVSWEKDTVSLVSGSRFLITSTG-ALYIKDVQNEDGLYNYRCITRHRYTGE 206
+ SW K+ + + LI G L I + DG Y CI ++ GE
Sbjct: 2989 SGFPPPDL---SWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDG-GEYTCIAINQ-AGE 3043
Query: 207 TRQSNSARLFVSDPANSAPSILDGFDHRKAMA----GQRVELPCKALGHPEPDYRWLKDN 262
+++ S ++V PSI D ++ G V L C++ P P W K+
Sbjct: 3044 SKKKFSLTVYVP------PSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNG 3097
Query: 263 MPLELSGRFQKTVTG--LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP 320
+ S + G L I+ SD+G YVC N G L V P
Sbjct: 3098 RMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPE 3157
Query: 321 RKV-KSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINH-ENLIMDHMVKS 378
R+V ++ + V+L+C TG ++W +N + + ++ + ++ L + S
Sbjct: 3158 REVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHS 3217
Query: 379 DGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAF--SEKVVSPAEPVSLMCNVKGTPLP 436
D G Y C + AQ Y + ++ P + A S+ V E V L+CN G P P
Sbjct: 3218 DSGNYTCIASNMEGKAQKYYFLSIQV-PPSVAGAEIPSDVSVLLGENVELVCNANGIPTP 3276
Query: 437 TITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQ 496
I W D PI G + RI +++ G S LNI + D G Y C A N AG
Sbjct: 3277 LIQWLKDGKPIASGETERIR--VSANG---STLNIYGALTSDTGKYTCVATNPAGEEDRI 3331
Query: 497 ARINVRGPASIRPMKN----ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVA 552
+NV +IR K+ + + I CR G P I W KN LP +
Sbjct: 3332 FNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRL 3391
Query: 553 FENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKV---PPFIQPFEFPRFSI 609
+++ Q D YTC V + + H ++V P ++
Sbjct: 3392 LAAGQVIRIVRAQVS-DVAVYTC---VASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITV 3447
Query: 610 --GQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNY 667
G + C+ P ++ W +DG+P+ +T+ L++ +G Y
Sbjct: 3448 LKGSSTSMACITDGTPAP-SMAWLRDGQPLGLDAHLTVSTHGMV--LQLLKAETEDSGKY 3504
Query: 668 TCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQD--GIYGKAVILNCSAEGYPVPTIVWKF 725
TCIA NEA V L V PP ++ I + L C A G P P + W
Sbjct: 3505 TCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW-- 3562
Query: 726 SKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
+ +P+ ++Q L G +L I ED+G Y C S+ G D K + V
Sbjct: 3563 -----MKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD-DKEYLVRV 3616
Query: 785 KIPAMI--TSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKE-DRIINPEMARYLVSTKE 841
+P I T P + ++ + C + P ++ W + +R+ R L +
Sbjct: 3617 HVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRY 3676
Query: 842 VGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 887
LQI D+ ++C A N G+ LTV PP+
Sbjct: 3677 --------LQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPN 3714
Score = 178 bits (451), Expect = 5e-44
Identities = 220/899 (24%), Positives = 346/899 (38%), Gaps = 89/899 (9%)
Query: 32 QEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSF 91
++V + T + C A PP T+ W+ G + IR + TLQI
Sbjct: 2583 EDVTVILNSPTSLVCEAYSYPPATITWF-KDGTPLESNRNIRILPGGRTLQIL------- 2634
Query: 92 STLIHDNT--YYCTAENPSGKIRSQ---DVHIKAVLRE---------PYTVRVEDQKTMR 137
DN Y C A N +G++ V+I ++ + P V+++ T+
Sbjct: 2635 -NAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLT 2693
Query: 138 GNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTG-ALYIKDVQNEDGLYNYR 196
+ IPS+ +SW KD L S I + G L IK+ Q D Y
Sbjct: 2694 LECEAY--AIPSA------SLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISD-TGRYT 2744
Query: 197 CITRHRYTGETRQSNSARLFVSDPANSAPSILDGFD------HRKAMAGQRVELPCKALG 250
C+ + GE + V I + D + + + L C+
Sbjct: 2745 CVASN-IAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNA 2803
Query: 251 HPEPDYRWLKDNMPLELSGRFQKTVTG--LLIENIRPSDSGSYVCEVSNRYG--TAKVIG 306
P P W KD PL S + G L I + D+G Y C N G + +
Sbjct: 2804 APPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDV 2863
Query: 307 RLYVKQPLKATIS--PRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITG 364
R+ V +K S P +V V + C +G+ SW ++G+ L + +
Sbjct: 2864 RVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLS 2923
Query: 365 INHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKV-VSPAEP 423
I++ + +D G Y C SA+ Y + + P +I SE + V
Sbjct: 2924 NGRILQILNTQI-TDIGRYVCVAENTAGSAKKYFNLNVH-VPPSVIGPKSENLTVVVNNF 2981
Query: 424 VSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYR 483
+SL C V G P P ++W ++ PI + +I G L I ++V DGG Y
Sbjct: 2982 ISLTCEVSGFPPPDLSWLKNEQPI----KLNTNTLIVPGGRT---LQIIRAKVSDGGEYT 3034
Query: 484 CTANNSAGVVLYQARINVRGPASIR-----PMKNITAIAGRDTYIHCRVIGYPYYSIKWY 538
C A N AG + + V P SI+ + + G + C P I WY
Sbjct: 3035 CIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWY 3094
Query: 539 KNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPF 598
KN ++ + + L + + D G+Y C + ++ H+ V VPP
Sbjct: 3095 KNGRMITESTHVEILADGQMLHIKKAEVS-DTGQYVCRA-INVAGRDDKNFHLNVYVPPS 3152
Query: 599 IQPFEFPRF--SIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRI 656
I+ E +I V + C +G P TI W K+ + I S + + + S L+I
Sbjct: 3153 IEGPEREVIVETISNPVTLTC-DATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQI 3211
Query: 657 SNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQ--PRDQDGIYGKAVILNCSAE 714
+ +GNYTCIA N + L ++VPP P D + G+ V L C+A
Sbjct: 3212 ARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNAN 3271
Query: 715 GYPVPTIVWKFSKGAGVPQFQPIAL--NGRIQVLSNGSLL-IKHVVEEDSGYYLCKVSND 771
G P P I W + +PIA RI+V +NGS L I + D+G Y C +N
Sbjct: 3272 GIPTPLIQW-------LKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNP 3324
Query: 772 VGAD---VSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRII 828
G + + ++Y+T I + + C A G P + W K +
Sbjct: 3325 AGEEDRIFNLNVYVTPTIRGN-KDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPL 3383
Query: 829 NPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPD 887
L++ +V ++I+ D ++C A N G D L V PP+
Sbjct: 3384 PLSSHIRLLAAGQV-------IRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPN 3435
Score = 124 bits (311), Expect = 9e-28
Identities = 130/484 (26%), Positives = 199/484 (41%), Gaps = 45/484 (9%)
Query: 27 VNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIYDVPGIR-HVHPNGTLQIFP 85
++ L+E V A + C A G+PP + W+ G I V IR V +G+LQI
Sbjct: 4081 ISPHLKEYVIAVDKPITLSCEADGLPPPDITWH-KDGRAI--VESIRQRVLSSGSLQIAF 4137
Query: 86 FPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVR-VEDQKTMRGNVAVFK 144
P Y C A N +G S K + P +R E T+ N +
Sbjct: 4138 VQPGD------AGHYTCMAANVAG---SSSTSTKLTVHVPPRIRSTEGHYTVNEN---SQ 4185
Query: 145 CIIPSSVEAYIT-VVSWEKDTVSLVS-GSRFLITSTGALYIKDVQNEDGLYNYRCITRHR 202
I+P + T ++W+KD V L + ++ G L +++V ED + Y C+ +
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGF-YTCVANNA 4244
Query: 203 YTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDN 262
GE + S + V P + G+++ L CKA G P P W +N
Sbjct: 4245 -AGEDTHTVSLTVHVLPTFTELPGDV------SLNKGEQLRLSCKATGIPLPKLTWTFNN 4297
Query: 263 MPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQ-PLKATISPR 321
+ + L+IE + DSG+YVC N G K IG +YVK+ P+ P
Sbjct: 4298 NIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPS 4357
Query: 322 KVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGG 381
+G L+C V G + W R G + +R G + +L + V D G
Sbjct: 4358 NWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLG--NGSLAIYGTVNEDAG 4415
Query: 382 AYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFS-EKVVSPAEPVSLMCNVKGTPLPTITW 440
Y C + + + + L+ +P II+ E V++ + L C G P PTITW
Sbjct: 4416 DYTCVATNEAGVVERSMSLTLQ--SPPIITLEPVETVINAGGKIILNCQATGEPQPTITW 4473
Query: 441 TLDDDPILKGGSHRISQMITSEGNVVS--YLNISSSQVRDGGVYRCTANNSAGVVLYQAR 498
+ H IS NV+S L I+ +Q D + C A N G VL +
Sbjct: 4474 SRQ--------GHSISW--DDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVP 4523
Query: 499 INVR 502
+ V+
Sbjct: 4524 VIVQ 4527
Score = 70.1 bits (170), Expect = 2e-11
Identities = 50/152 (32%), Positives = 70/152 (46%), Gaps = 25/152 (16%)
Query: 1262 VAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMK 1321
+A AG ++S +TV P RI + G T +LPC A G P+PA+ W K
Sbjct: 4149 MAANVAGSSSTSTKLTVH----VPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKK 4204
Query: 1322 DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPD 1381
D+ L + G+ + G I+ V EDSG+Y+C+ANN G D ++L V V P
Sbjct: 4205 DN---VLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLP- 4260
Query: 1382 QPRLTVSKTTSSSITLSWLPGD---NGGSSIR 1410
T + LPGD N G +R
Sbjct: 4261 --------------TFTELPGDVSLNKGEQLR 4278
Score = 54.3 bits (129), Expect = 1e-06
Identities = 30/80 (37%), Positives = 41/80 (51%), Gaps = 4/80 (5%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
K I L C+A G P P + W KD + R+ + S+GS I V+ D+G+Y+C+
Sbjct: 4094 KPITLSCEADGLPPPDITWHKDGRAIVESI----RQRVLSSGSLQIAFVQPGDAGHYTCM 4149
Query: 1361 ANNNWGSDEIILNLQVQVPP 1380
A N GS L V VPP
Sbjct: 4150 AANVAGSSSTSTKLTVHVPP 4169
Score = 53.9 bits (128), Expect = 2e-06
Identities = 32/99 (32%), Positives = 53/99 (53%), Gaps = 11/99 (11%)
Query: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS---IFSNGSFIIRTVKAEDSGYYSCIA 1361
L C+A G P P++ W K+ + L+ +D ++ + S+GS +I + +D+ Y C
Sbjct: 3823 LACEATGIPKPSINWRKNGH----LLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTV 3878
Query: 1362 NNNWGSDEIILNLQVQVPP---DQPR-LTVSKTTSSSIT 1396
N G D+ ++L VQVPP D+P V+K + IT
Sbjct: 3879 TNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT 3917
Score = 53.5 bits (127), Expect = 2e-06
Identities = 27/77 (35%), Positives = 40/77 (51%), Gaps = 5/77 (6%)
Query: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFS-NGSFIIRTVKAEDSGYYSCIANN 1363
+PC A G P P + W K S + +DG + + +G+ I D+G Y+C+A N
Sbjct: 1190 IPCNAQGTPLPVITWSKGG----STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATN 1245
Query: 1364 NWGSDEIILNLQVQVPP 1380
G+DE + L VQ PP
Sbjct: 1246 IAGTDETEITLHVQEPP 1262
Score = 52.8 bits (125), Expect = 3e-06
Identities = 28/84 (33%), Positives = 46/84 (54%), Gaps = 5/84 (5%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI-IRTVKAEDSGYYSCIA 1361
+ L C+A PS ++ W KD S D +I +NG + I+ + D+G Y+C+A
Sbjct: 2692 LTLECEAYAIPSASLSWYKDGQPLKS----DDHVNIAANGHTLQIKEAQISDTGRYTCVA 2747
Query: 1362 NNNWGSDEIILNLQVQVPPDQPRL 1385
+N G DE+ ++ +QVPP +L
Sbjct: 2748 SNIAGEDELDFDVNIQVPPSFQKL 2771
Score = 52.0 bits (123), Expect = 6e-06
Identities = 50/182 (27%), Positives = 74/182 (40%), Gaps = 20/182 (10%)
Query: 1219 IRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITV 1278
I+ + +PY TV S+ S L +Y+ V +S ++ V
Sbjct: 925 IKNSAMLLQNPYITVRSD-----GSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHV 979
Query: 1279 EPLAKAPARIL-TFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS 1337
P + +IL T G T LPCKA G+P P+V W K + T + S
Sbjct: 980 LPTIQHGQQILSTIEGIPVT-------LPCKASGNPKPSVIWSKKGE---LISTSSAKFS 1029
Query: 1338 IFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP----DQPRLTVSKTTSS 1393
++GS + + E+SG Y C A N G + + L V V P DQ L+ K
Sbjct: 1030 AGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEI 1089
Query: 1394 SI 1395
S+
Sbjct: 1090 SV 1091
Score = 52.0 bits (123), Expect = 6e-06
Identities = 59/218 (27%), Positives = 80/218 (36%), Gaps = 35/218 (16%)
Query: 1215 LNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSE 1274
+N I Y + P PT+ + P + S ++ L R + V AGR
Sbjct: 2791 INNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVA 2850
Query: 1275 I-------------ITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMK 1321
+ + V P+ K L TV K ++ C + G P+P W K
Sbjct: 2851 VNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVN--KSALIECLSSGSPAPRNSWQK 2908
Query: 1322 DSNGTPSLVTIDGRRSIFSNGSFI-IRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
D G P L D SNG + I + D G Y C+A N GS + NL V VPP
Sbjct: 2909 D--GQPLLE--DDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPP 2964
Query: 1381 D-----QPRLTVSKTTSSSIT----------LSWLPGD 1403
LTV S+T LSWL +
Sbjct: 2965 SVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNE 3002
Score = 51.6 bits (122), Expect = 8e-06
Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 8/94 (8%)
Query: 1291 FSGTVTTPWMKDI----VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFII 1346
F G + W++ + +L C+ GDP+P ++W + + I R NGS I
Sbjct: 4351 FKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVD----IEISHRIRQLGNGSLAI 4406
Query: 1347 RTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
ED+G Y+C+A N G E ++L +Q PP
Sbjct: 4407 YGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPP 4440
Score = 51.2 bits (121), Expect = 1e-05
Identities = 48/182 (26%), Positives = 77/182 (42%), Gaps = 22/182 (12%)
Query: 1208 SWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVW------- 1260
+W+ PL N I+ P PT+ + S+RI L N +++
Sbjct: 4358 NWIEPLGGNAILNCEVK--GDPTPTIQWNRKGVDIEISHRIRQLG-NGSLAIYGTVNEDA 4414
Query: 1261 ----VVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPA 1316
VA AG S +T++ P L TV K I+L C+A G+P P
Sbjct: 4415 GDYTCVATNEAGVVERSMSLTLQ---SPPIITLEPVETVINAGGK-IILNCQATGEPQPT 4470
Query: 1317 VKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV 1376
+ W + + ++ D R ++ SN S I + ED+ + C+A N GS + + + V
Sbjct: 4471 ITWSRQGHS----ISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526
Query: 1377 QV 1378
QV
Sbjct: 4527 QV 4528
Score = 50.8 bits (120), Expect = 1e-05
Identities = 34/101 (33%), Positives = 53/101 (52%), Gaps = 13/101 (12%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAE--DSGYYSCI 1360
I + C+A G P P + W+K NG P + + + + G +IR V+A+ D Y+C+
Sbjct: 3360 INIECRATGTPPPQINWLK--NGLP--LPLSSHIRLLAAGQ-VIRIVRAQVSDVAVYTCV 3414
Query: 1361 ANNNWGSDEIILNLQVQVPPDQ------PRLTVSKTTSSSI 1395
A+N G D NLQV PP+ +TV K +S+S+
Sbjct: 3415 ASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSM 3455
Score = 50.4 bits (119), Expect = 2e-05
Identities = 30/82 (36%), Positives = 42/82 (51%), Gaps = 10/82 (12%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRR---SIFSNGSF-IIRTVKAEDSGYYS 1358
I PC A G P P +KW+ + + GR SI +G+ +I +V D+G Y
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGR------ELTGREPGISILEDGTLLVIASVTPYDNGEYI 1337
Query: 1359 CIANNNWGSDEIILNLQVQVPP 1380
C+A N G+ E NL+V VPP
Sbjct: 1338 CVAVNEAGTTERKYNLKVHVPP 1359
Score = 50.1 bits (118), Expect = 2e-05
Identities = 55/226 (24%), Positives = 88/226 (38%), Gaps = 27/226 (11%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI-IRTVKAEDSGYYSC 1359
K + L C A G P+P++ W+KD + T G I S+G + I ED+G Y+C
Sbjct: 1842 KPVALQCIANGIPNPSITWLKDDQ---PVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTC 1898
Query: 1360 IANNNWGSDEIILNLQVQVPPD----QPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQ 1415
+A N G + + L V PP L + S+ + L N I Y
Sbjct: 1899 VATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWY--- 1955
Query: 1416 YSEDNSEQWGSFPISPSERS--YRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGK 1473
+DN GS ++ R +E+ + + A N G +E+ + +
Sbjct: 1956 --KDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAG---ATELFYSLQVHV 2010
Query: 1474 EPQFSKEQELFASINTTRVRLNL---------IGWNDGGCPITSFT 1510
P S + A + VRL + W G P++SF+
Sbjct: 2011 APSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFS 2056
Score = 49.3 bits (116), Expect = 4e-05
Identities = 25/80 (31%), Positives = 38/80 (47%), Gaps = 3/80 (3%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
+++ LPC+ P P + W K+ T + R + +GS I + DSG Y C+
Sbjct: 1095 EEVTLPCEVKSLPPPIITWAKE---TQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCV 1151
Query: 1361 ANNNWGSDEIILNLQVQVPP 1380
A N G+ + L V VPP
Sbjct: 1152 ATNIAGNVTQAVKLNVHVPP 1171
Score = 49.3 bits (116), Expect = 4e-05
Identities = 34/120 (28%), Positives = 62/120 (51%), Gaps = 6/120 (5%)
Query: 1262 VAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMK 1321
VA+ SAG ++E+ + AP+ I + V + L C+A G P+P++ W+K
Sbjct: 1992 VAINSAG---ATELFYSLQVHVAPS-ISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLK 2047
Query: 1322 DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPD 1381
D G+P +G + + + + + D+G Y+C+A N G + ++L+V VPP+
Sbjct: 2048 D--GSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPN 2105
Score = 49.3 bits (116), Expect = 4e-05
Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 8/85 (9%)
Query: 1305 LPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNN 1364
L C A G P+P + WMKD P D +++ I T + ED+G Y+C+A++
Sbjct: 3548 LTCIASGIPAPKMTWMKDGRPLPQT---DQVQTLGGGEVLRISTAQVEDTGRYTCLASSP 3604
Query: 1365 WGSDEIILNLQVQVPP-----DQPR 1384
G D+ ++V VPP D+PR
Sbjct: 3605 AGDDDKEYLVRVHVPPNIAGTDEPR 3629
Score = 47.4 bits (111), Expect = 1e-04
Identities = 46/166 (27%), Positives = 67/166 (40%), Gaps = 25/166 (15%)
Query: 1215 LNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSE 1274
L ++ KYT + PY +I E DS Y VA +AG +
Sbjct: 4209 LANLLGKYT---AEPYGELILENVVLEDSGFYTC-------------VANNAAGEDTHTV 4252
Query: 1275 IITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDG 1334
+TV L G V+ + + L CKA G P P + W ++N P+
Sbjct: 4253 SLTVHVLPT----FTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFD--- 4305
Query: 1335 RRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
S+ + +I V EDSG Y C A N+ G + I + V+ PP
Sbjct: 4306 --SVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP 4349
Score = 43.5 bits (101), Expect = 0.002
Identities = 41/165 (24%), Positives = 70/165 (42%), Gaps = 19/165 (11%)
Query: 1229 PYPTVISEFEASP-DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIIT-------VEP 1280
P P++ + SP SFS + LS R ++ ++ GR + ++
Sbjct: 2039 PAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDL 2098
Query: 1281 LAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSL----VTIDGRR 1336
P I+ V+ + + L C++ P P + W+KD G P L ++I R
Sbjct: 2099 RVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKD--GHPLLKKPGLSISENR 2156
Query: 1337 SIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPD 1381
S+ I + +D+G Y+C A N G E N+ + VPP+
Sbjct: 2157 SVLK-----IEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPN 2196
Score = 43.5 bits (101), Expect = 0.002
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 8/100 (8%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI-IRTVKAEDSGYYSCIA 1361
+ L C++ P P + W K+ ++T I ++G + I+ + D+G Y C A
Sbjct: 3077 VSLECESNAVPPPVITWYKNGR----MITESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 1362 NNNWGSDEIILNLQVQVPPD---QPRLTVSKTTSSSITLS 1398
N G D+ +L V VPP R + +T S+ +TL+
Sbjct: 3133 INVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLT 3172
Score = 43.1 bits (100), Expect = 0.003
Identities = 24/81 (29%), Positives = 47/81 (58%), Gaps = 5/81 (6%)
Query: 1301 KDIVLPCKAV-GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC 1359
+ + LPC + G+P P +W+K+S +++ + ++ S+GS I V+ +D G Y+C
Sbjct: 905 QQLTLPCTLLAGNPIPERRWIKNS----AMLLQNPYITVRSDGSLHIERVQLQDGGEYTC 960
Query: 1360 IANNNWGSDEIILNLQVQVPP 1380
+A+N G++ ++ V V P
Sbjct: 961 VASNVAGTNNKTTSVVVHVLP 981
Score = 42.0 bits (97), Expect = 0.006
Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 6/119 (5%)
Query: 1262 VAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMK 1321
+AV+SAG G + V P ++ VT + VL C + + W +
Sbjct: 500 IAVSSAGTGRAQTFFDVSE----PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQR 555
Query: 1322 DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP 1380
N + R +N S +++VK D+G Y C+ ++ GS + L VQ PP
Sbjct: 556 --NDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPP 612
Score = 42.0 bits (97), Expect = 0.006
Identities = 23/105 (21%), Positives = 47/105 (44%), Gaps = 8/105 (7%)
Query: 1265 TSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSN 1324
+ G +S +TV+ P ++ + ++ + C A G P P + W +
Sbjct: 595 SEGGSSAASVFLTVQE----PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVND- 649
Query: 1325 GTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDE 1369
+ R + S+G+ I+ +D+G Y C+A+N+ G+D+
Sbjct: 650 ---MFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDK 691
Score = 39.3 bits (90), Expect = 0.039
Identities = 42/143 (29%), Positives = 60/143 (41%), Gaps = 19/143 (13%)
Query: 1262 VAVTSAG---RGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVK 1318
+A SAG + ++ I L + +L G +T V+ CK G P P VK
Sbjct: 682 LASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDIT-------VMECKTSGIPPPQVK 734
Query: 1319 WMK-DSNGTPS-LVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQV 1376
W K D PS + ID + I+ + D+G Y+C+A N G + L V
Sbjct: 735 WFKGDLELRPSTFLIIDPLLGLLK-----IQETQDLDAGDYTCVAINEAGRATGKITLDV 789
Query: 1377 QVPP--DQPRLTVSKTTSSSITL 1397
PP Q VS S++TL
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTL 812
Score = 38.9 bits (89), Expect = 0.051
Identities = 30/109 (27%), Positives = 43/109 (39%), Gaps = 11/109 (10%)
Query: 1262 VAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMK 1321
VA+ AGR + V +P + V+ ++ LPC G P P +KW +
Sbjct: 773 VAINEAGRATGKITLDVG----SPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRR 828
Query: 1322 DSN----GTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
N P V+ S G+ I + A D G Y C A N +G
Sbjct: 829 LDNMPIFSRPFSVS---SISQLRTGALFILNLWASDKGTYICEAENQFG 874
Score = 38.1 bits (87), Expect = 0.088
Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 5/82 (6%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI-IRTVKAEDSGYYSC 1359
+ + L CK+ P P + W++ NG T R I S G ++ I D+ Y+C
Sbjct: 3637 RQVTLECKSDAVPPPVITWLR--NGERLQAT--PRVRILSGGRYLQINNADLGDTANYTC 3692
Query: 1360 IANNNWGSDEIILNLQVQVPPD 1381
+A+N G L V VPP+
Sbjct: 3693 VASNIAGKTTREFILTVNVPPN 3714
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 239 bits (609), Expect = 3e-62
Identities = 243/933 (26%), Positives = 393/933 (42%), Gaps = 75/933 (8%)
Query: 330 QVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK 389
+V+L+C V G W RNG ++ + R + I+ +I + D G YQC
Sbjct: 118 KVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATN 177
Query: 390 DK---LSAQDYVQVV-LEDGTPKIISAFSEKVVSPAEPVSLMCNVKG-TPLPTITWTLDD 444
LS + +Q L + + + SA S V + V LMC+ +P +W ++
Sbjct: 178 TVGSILSREATLQFAYLGNFSGRTRSAVS---VREGQGVVLMCSPPPHSPEIIYSWVFNE 234
Query: 445 DPILKGGSHRISQMITSE-GNVVSYLNISSSQVRDGGVYRCTANNSA------------- 490
P R + I+ E GN L IS Q D G Y C N+
Sbjct: 235 FPSFVAEDSR--RFISQETGN----LYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLT 288
Query: 491 ----GVV-LYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLP 545
GV+ Y+ +I V P ++ TA G + C +G P +I W K + +P
Sbjct: 289 LRNDGVMGEYEPKIEVHFPFTV------TAAKGTTVKMECFALGNPVPTITWMKVNGYIP 342
Query: 546 FNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFP 605
R ++ L++ +VQ + D G Y C ++ + P +++
Sbjct: 343 SKAR--LRKSQAVLEIPNVQLD-DAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDT 399
Query: 606 RFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNG 665
+ G + C P T W K+G P+ V + N L I N++ G
Sbjct: 400 QLDSGSPLRWECKATGKPRP-TYRWLKNGVPLSPQSRVEMVN----GVLMIHNVNQSDAG 454
Query: 666 NYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPRDQDGIYGK--AVILNCSAEGYPVPTIV 722
Y C+A N+ A+ ++L I+ P F + + I K V++ C +G P PTI
Sbjct: 455 MYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTIS 514
Query: 723 WKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMY 781
WK A + N RI +L +GSL I + + D G Y+C+ N G A++ S
Sbjct: 515 WKKGDRA-------VRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIAS-- 565
Query: 782 LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR--WEKEDRIIN-PEMARYLVS 838
L+VK P I P T T G+ ++C A + + V W + + I+ E + S
Sbjct: 566 LSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFES 625
Query: 839 TKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEI-KDVK 897
+ + L I + +G + C + +L V+ PP PP I I +++
Sbjct: 626 IRAQASS--ADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEIT 683
Query: 898 ARTITLRWTMGFDGNSPITGYDIECKNK-SDSWDSAQRTKDV-SPQLNSATIIDIHPSST 955
T TL W+ D +SPI+ Y+++ ++ S W + + ++ + + SA +D++P
Sbjct: 684 ESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 743
Query: 956 YSIRMYAKNRIGKSEPSN-ELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQN 1014
Y R+ A N IG +PS I +EA P P V + + W+ + QN
Sbjct: 744 YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQN 803
Query: 1015 GIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGP 1074
G GY + +R T G + + S + S +Y +++ T + + V N G GP
Sbjct: 804 GEGFGYIVAFRPNGTRGWKEKMVTSSEAS--KFIYRDESVPPLTPFEVKVGVYNNKGDGP 861
Query: 1075 SSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMD 1134
SQ ++ + E PS P +V+A + S I ++W + KE+L G QGF V YW ++
Sbjct: 862 FSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHI-KESL-GRPQGFEVGYWKDMEQ 919
Query: 1135 GELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAG 1194
+ E + + L GLE T Y V A+ AG G S ++ TK+ P
Sbjct: 920 EDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPS 979
Query: 1195 VKAAAASASMVFVSWLP--PLKLNGIIRKYTVF 1225
S V + W P PL + Y VF
Sbjct: 980 NLRWEQQGSQVSLGWEPVIPLANESEVVGYKVF 1012
Score = 177 bits (450), Expect = 7e-44
Identities = 199/821 (24%), Positives = 333/821 (40%), Gaps = 68/821 (8%)
Query: 419 SPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRD 478
S + V+L C V+G P+P+ W + I +R S + +G +++ + S+ +D
Sbjct: 114 SDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI---DG---TFIISNPSEAKD 167
Query: 479 GGVYRCTANNSAGVVLYQ---ARINVRGPASIRPMKNITAIAGRDTYIHCRVIGY-PYYS 534
G Y+C A N+ G +L + + G S R ++ G+ + C + P
Sbjct: 168 SGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEII 227
Query: 535 IKWYKNS--NLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC---------NVLVQPQL 583
W N + + + R+ + G L +S VQ D G Y C VL P
Sbjct: 228 YSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTS-DVGSYICLVKNTVTNARVLSPPTP 286
Query: 584 STSQSVHVTVKVPPFIQPFEFPRFSI----GQRVFIPCVVVSGDLPITITWQKDGRPIPG 639
T ++ V + P I+ FP F++ G V + C + +P TITW K IP
Sbjct: 287 LTLRNDGVMGEYEPKIE-VHFP-FTVTAAKGTTVKMECFALGNPVP-TITWMKVNGYIPS 343
Query: 640 SLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQ 699
+ + L I N+ L G Y C A N + QL V P +V + D
Sbjct: 344 KARLRKSQ----AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDT 399
Query: 700 DGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEE 759
G + C A G P PT W + P++ R++++ NG L+I +V +
Sbjct: 400 QLDSGSPLRWECKATGKPRPTYRW-------LKNGVPLSPQSRVEMV-NGVLMIHNVNQS 451
Query: 760 DSGYYLCKVSNDVGA-DVSKSMYLTVKIPAM-ITSYPNTTLATQGQKKEMSCTAHGEKPI 817
D+G Y C N GA S + + P + T + T+ Q+ + C G
Sbjct: 452 DAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP 511
Query: 818 IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGI 877
+ W+K DR + K + +L+IL + D G + C N +G I
Sbjct: 512 TISWKKGDRAVR--------ENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEII 563
Query: 878 IQLTVQEPP----DPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQ 933
L+V+EP P E+ +I L D + +T Y D +
Sbjct: 564 ASLSVKEPTRIELTPKRTEL--TVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGG 621
Query: 934 RTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHL 993
+ + Q +SA ++ + ++ R + + S+E + P GPP V +
Sbjct: 622 HFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLV--RGPPGPPGIVIV 679
Query: 994 EPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDN 1053
E I+ + ++W + + I Y + R + G + +GD E +
Sbjct: 680 EEITESTATLSWSPAADN--HSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVD 737
Query: 1054 LNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTL 1112
LN + +Y V A N GTG PS+ + T E VP P NV + + I+W +
Sbjct: 738 LNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPV 797
Query: 1113 SKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLEL---DGLEKYTNYSIQVLAFT 1169
S+E NG G+ V + N G + K +T+++ S + + + T + ++V +
Sbjct: 798 SEEFQNGEGFGYIVAFRPNGTRG--WKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYN 855
Query: 1170 RAGDGVRSEQIFTRTKEDVP-GPPAGVKAAAASASMVFVSW 1209
GDG S+ + + E P P VKA + S S + V+W
Sbjct: 856 NKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAW 896
Score = 166 bits (419), Expect = 3e-40
Identities = 231/1011 (22%), Positives = 386/1011 (38%), Gaps = 137/1011 (13%)
Query: 240 QRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTV---TGLLIENIRPSDSGSYVCEVS 296
++V L C+ G+P P YRWL++ ++L ++ ++ T ++ DSG Y C +
Sbjct: 117 KKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLAT 176
Query: 297 NRYGTAKVIGRLYVKQPLKATISPRKVKSSV----GSQVSLSCSVTGTEDQEL-SW-YRN 350
N G+ ++ R Q + +S+V G V L CS + + SW +
Sbjct: 177 NTVGS--ILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNE 234
Query: 351 GEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKII 410
+ R NL + + SD G+Y C V+ +A+ VL TP +
Sbjct: 235 FPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNAR-----VLSPPTP--L 287
Query: 411 SAFSEKVVSPAEP-----------------VSLMCNVKGTPLPTITWTLDDDPILKGGSH 453
+ ++ V+ EP V + C G P+PTITW + I
Sbjct: 288 TLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARL 347
Query: 454 RISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV-RGPASIRPMKN 512
R SQ + L I + Q+ D G+Y C A NS G ++ ++ V P + + +
Sbjct: 348 RKSQAV---------LEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLND 398
Query: 513 ITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGE 572
+G C+ G P + +W KN +P + + NG L + +V + D G
Sbjct: 399 TQLDSGSPLRWECKATGKPRPTYRWLKNG--VPLSPQSRVEMVNGVLMIHNVNQS-DAGM 455
Query: 573 YTCNVLVQPQ---LSTSQSVHVTVKVPPFI--QPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
Y C L + + + S + + P F Q + + Q V I C P T
Sbjct: 456 YQC--LAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKP-T 512
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
I+W+K R + + + I SLRI N S G Y C N + E + L V+
Sbjct: 513 ISWKKGDRAVRENKRIAILP---DGSLRILNASKSDEGKYVCRGENVFGSAEIIASLSVK 569
Query: 688 VPPKFVVQPRDQDGIYGKAVILNCSA--EGYPVPTIVWKFSKGAGVPQFQPIAL---NGR 742
P + + P+ + G++++LNC A + T W KG QPI G
Sbjct: 570 EPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTL-KG------QPIDFEEEGGH 622
Query: 743 IQVL----SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP------AMITS 792
+ + S+ L+I++++ +G Y C+V + VS L V+ P ++
Sbjct: 623 FESIRAQASSADLMIRNILLMHAGRYGCRVQTTADS-VSDEAELLVRGPPGPPGIVIVEE 681
Query: 793 YPNTTL------ATQGQKKEMSCTAHGEKPIIVRWEKEDRI---------------INP- 830
+T A S P + W+ + +NP
Sbjct: 682 ITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPW 741
Query: 831 -EMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPP 889
E +V+T +G ST + +R + N G +L + P
Sbjct: 742 VEYEFRVVATNPIGTGDPSTPSRM--IRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSE 799
Query: 890 EIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIID 949
E + + + R + G+ + S++ R + V P
Sbjct: 800 EFQNGEGFGYIVAFR-------PNGTRGWKEKMVTSSEASKFIYRDESVPP--------- 843
Query: 950 IHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPK 1009
+ + +++ N G S + I + E P P +V +S I V WK K
Sbjct: 844 ---LTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK 900
Query: 1010 KHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNR 1069
+ L G +G+++GY + + +V T G+ L L T Y V+A N
Sbjct: 901 ESL--GRPQGFEVGYWK---DMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNG 955
Query: 1070 AGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYW 1129
AG GP S E+ TT + PS P N++ +S+ W + A + G++V Y
Sbjct: 956 AGYGPPSSEVSATTKKSPPSQAPSNLR-WEQQGSQVSLGWEPVIPLANESEVVGYKVFY- 1013
Query: 1130 ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQI 1180
+G + TQ + L Y I+V A++ GDG S QI
Sbjct: 1014 --RQEGHSN--SQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQI 1060
Score = 121 bits (304), Expect = 6e-27
Identities = 140/570 (24%), Positives = 224/570 (39%), Gaps = 39/570 (6%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAE 105
C G P + RW L G EI R+ +GT I S+ S Y C A
Sbjct: 123 CEVRGNPVPSYRW-LRNGTEIDLESDYRYSLIDGTFII-----SNPSEAKDSGHYQCLAT 176
Query: 106 NPSGKIRSQDVHIKAVLREPYTVRVEDQKTMR-GNVAVFKCIIPS-SVEAYITVVSWEKD 163
N G I S++ ++ ++ R ++R G V C P S E + V E
Sbjct: 177 NTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFP 236
Query: 164 TVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPA-- 221
+ RF+ TG LYI VQ D + +Y C+ ++ T S L + +
Sbjct: 237 SFVAEDSRRFISQETGNLYISKVQTSD-VGSYICLVKNTVTNARVLSPPTPLTLRNDGVM 295
Query: 222 -NSAPSILDGFDHRKAMA-GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL 279
P I F A G V++ C ALG+P P W+K N + R +K+ L
Sbjct: 296 GEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLE 355
Query: 280 IENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTG 339
I N++ D+G Y C N G G+L V + GS + C TG
Sbjct: 356 IPNVQLDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATG 415
Query: 340 TEDQELSWYRNGEILNPGKNVR-ITGINHENLIMDHMVKSDGGAYQCFV--RKDKLSAQD 396
W +NG L+P V + G+ L++ ++ +SD G YQC + + A
Sbjct: 416 KPRPTYRWLKNGVPLSPQSRVEMVNGV----LMIHNVNQSDAGMYQCLAENKYGAIYASA 471
Query: 397 YVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRIS 456
++++ T + +V+ + V + C +G+P PTI+W D + + + RI+
Sbjct: 472 ELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRE--NKRIA 529
Query: 457 QMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR-PMKNITA 515
I +G+ L I ++ D G Y C N G A ++V+ P I K
Sbjct: 530 --ILPDGS----LRILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTEL 583
Query: 516 IAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQV--------AFENNGTLKLSDVQKE 567
G ++C+ I + +Y P + + A ++ L + ++
Sbjct: 584 TVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL- 642
Query: 568 VDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597
+ G Y C V S S + V+ PP
Sbjct: 643 MHAGRYGCRVQTTAD-SVSDEAELLVRGPP 671
Score = 70.9 bits (172), Expect = 1e-11
Identities = 231/1065 (21%), Positives = 387/1065 (36%), Gaps = 180/1065 (16%)
Query: 596 PPFIQPFE---FPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS 652
P F+Q + FP S ++V + C V +P + W ++G I ID T
Sbjct: 99 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVP-SYRWLRNGTEIDLESDYRYSLIDGT- 156
Query: 653 SLRISNLS-LMHNGNYTCIARNEAAAV-EHQSQLIVRVPPKFVVQPRDQDGIY-GKAVIL 709
ISN S +G+Y C+A N ++ ++ L F + R + G+ V+L
Sbjct: 157 -FIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVL 215
Query: 710 NCSAEGYPVPTIV--WKFSKGAGVPQFQPIALNGRIQVLSN-GSLLIKHVVEEDSGYYLC 766
CS + P I+ W F++ P F +A + R + G+L I V D G Y+C
Sbjct: 216 MCSPPPHS-PEIIYSWVFNE---FPSF--VAEDSRRFISQETGNLYISKVQTSDVGSYIC 269
Query: 767 KVSNDV--GADVSKSMYLTVKIPAMITSY--------PNTTLATQGQKKEMSCTAHGEKP 816
V N V +S LT++ ++ Y P T A +G +M C A G
Sbjct: 270 LVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPV 329
Query: 817 IIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRG 876
+ W K + I P AR S + L+I +D+G + C A NS G++
Sbjct: 330 PTITWMKVNGYI-PSKARLRKSQ--------AVLEIPNVQLDDAGIYECRAENSRGKNSF 380
Query: 877 IIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTK 936
QL V P E ++ D + D SP+ ECK + + K
Sbjct: 381 RGQLQVYTYPHWVE-KLNDTQ-----------LDSGSPLRW---ECKATGKPRPTYRWLK 425
Query: 937 D---VSPQ-----LNSATII-DIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD-- 985
+ +SPQ +N +I +++ S + A+N+ G S EL I A +AP
Sbjct: 426 NGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILA--SAPTFA 483
Query: 986 ----------GPPQEVHLE--PISSQSIRVTWK----APKKHLQNGIIRGYQIGYREYST 1029
QEV +E P S ++WK A +++ + I+ + S
Sbjct: 484 LNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK 543
Query: 1030 GGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPS 1089
++ + G +E+ L V+ R P E+ T E +
Sbjct: 544 SDEGKYVCRGENVFGSAEIIA----------SLSVKEPTRIELTPKRTEL--TVGESIVL 591
Query: 1090 YPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPS 1149
N +AI + ++ W TL + ++ + E G ++I S
Sbjct: 592 ----NCKAIHDASLDVTFYW-TLKGQPID--------------FEEEGGHFESIRAQASS 632
Query: 1150 LELDGLEKYTNYSIQVLAFTRAGD-GVRSEQIFTRTKEDV-------PGPPAGVKAAAAS 1201
+L I+ + AG G R + ++ PGPP V +
Sbjct: 633 ADL---------MIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEIT 683
Query: 1202 ASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASP-----DSFSYRIPNLSRNRQ 1256
S +SW P + I Y + P+ + P D S +L+ +
Sbjct: 684 ESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 743
Query: 1257 YSVWVVAVTSAGRGNSSE----IITVEPLAK-APARILTFSGTVTTPWMKDIVLPCKAVG 1311
Y VVA G G+ S I T E + K AP + SG ++V+ + V
Sbjct: 744 YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGR-----RHELVIAWEPVS 798
Query: 1312 D---------------PSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356
+ P+ W K+ T S + + I+ + S T G
Sbjct: 799 EEFQNGEGFGYIVAFRPNGTRGW-KEKMVTSS----EASKFIYRDESVPPLTPFEVKVGV 853
Query: 1357 YSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQY 1416
Y+ + + +I + + + + + + S I ++W +G+ + Y
Sbjct: 854 YNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGY 913
Query: 1417 SEDNSEQWGSFPISP--SERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474
+D ++ + + +E L L+ T Y FT+ A NG G G S + A T K
Sbjct: 914 WKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSA-TTKKS 972
Query: 1475 PQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVW------TTAQRTS 1528
P L ++V L GW P+ E G V+ + +Q
Sbjct: 973 PPSQAPSNLRWEQQGSQVSL---GWE----PVIPLANESEVVGYKVFYRQEGHSNSQVIE 1025
Query: 1529 LSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTI 1573
K + L +A Y +++R + G + +Y G I
Sbjct: 1026 TQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKI 1070
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 239 bits (609), Expect = 3e-62
Identities = 243/933 (26%), Positives = 393/933 (42%), Gaps = 75/933 (8%)
Query: 330 QVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK 389
+V+L+C V G W RNG ++ + R + I+ +I + D G YQC
Sbjct: 44 KVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATN 103
Query: 390 DK---LSAQDYVQVV-LEDGTPKIISAFSEKVVSPAEPVSLMCNVKG-TPLPTITWTLDD 444
LS + +Q L + + + SA S V + V LMC+ +P +W ++
Sbjct: 104 TVGSILSREATLQFAYLGNFSGRTRSAVS---VREGQGVVLMCSPPPHSPEIIYSWVFNE 160
Query: 445 DPILKGGSHRISQMITSE-GNVVSYLNISSSQVRDGGVYRCTANNSA------------- 490
P R + I+ E GN L IS Q D G Y C N+
Sbjct: 161 FPSFVAEDSR--RFISQETGN----LYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLT 214
Query: 491 ----GVV-LYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLP 545
GV+ Y+ +I V P ++ TA G + C +G P +I W K + +P
Sbjct: 215 LRNDGVMGEYEPKIEVHFPFTV------TAAKGTTVKMECFALGNPVPTITWMKVNGYIP 268
Query: 546 FNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFP 605
R ++ L++ +VQ + D G Y C ++ + P +++
Sbjct: 269 SKAR--LRKSQAVLEIPNVQLD-DAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDT 325
Query: 606 RFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNG 665
+ G + C P T W K+G P+ V + N L I N++ G
Sbjct: 326 QLDSGSPLRWECKATGKPRP-TYRWLKNGVPLSPQSRVEMVN----GVLMIHNVNQSDAG 380
Query: 666 NYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPRDQDGIYGK--AVILNCSAEGYPVPTIV 722
Y C+A N+ A+ ++L I+ P F + + I K V++ C +G P PTI
Sbjct: 381 MYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTIS 440
Query: 723 WKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVG-ADVSKSMY 781
WK A + N RI +L +GSL I + + D G Y+C+ N G A++ S
Sbjct: 441 WKKGDRA-------VRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAEIIAS-- 491
Query: 782 LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR--WEKEDRIIN-PEMARYLVS 838
L+VK P I P T T G+ ++C A + + V W + + I+ E + S
Sbjct: 492 LSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFES 551
Query: 839 TKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEI-KDVK 897
+ + L I + +G + C + +L V+ PP PP I I +++
Sbjct: 552 IRAQASS--ADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEIT 609
Query: 898 ARTITLRWTMGFDGNSPITGYDIECKNK-SDSWDSAQRTKDV-SPQLNSATIIDIHPSST 955
T TL W+ D +SPI+ Y+++ ++ S W + + ++ + + SA +D++P
Sbjct: 610 ESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 669
Query: 956 YSIRMYAKNRIGKSEPSN-ELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQN 1014
Y R+ A N IG +PS I +EA P P V + + W+ + QN
Sbjct: 670 YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQN 729
Query: 1015 GIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGP 1074
G GY + +R T G + + S + S +Y +++ T + + V N G GP
Sbjct: 730 GEGFGYIVAFRPNGTRGWKEKMVTSSEAS--KFIYRDESVPPLTPFEVKVGVYNNKGDGP 787
Query: 1075 SSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMD 1134
SQ ++ + E PS P +V+A + S I ++W + KE+L G QGF V YW ++
Sbjct: 788 FSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHI-KESL-GRPQGFEVGYWKDMEQ 845
Query: 1135 GELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAG 1194
+ E + + L GLE T Y V A+ AG G S ++ TK+ P
Sbjct: 846 EDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPS 905
Query: 1195 VKAAAASASMVFVSWLP--PLKLNGIIRKYTVF 1225
S V + W P PL + Y VF
Sbjct: 906 NLRWEQQGSQVSLGWEPVIPLANESEVVGYKVF 938
Score = 124 bits (311), Expect = 9e-28
Identities = 149/613 (24%), Positives = 240/613 (39%), Gaps = 43/613 (7%)
Query: 6 LSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTG---TLVPCPAAGIPPVTLRWYLAT 62
L LF S SE + FV +++F + + + C G P + RW L
Sbjct: 7 LMLFLSVTMCLSESVDYGPVFVQEP-DDIIFPTDSDEKKVALNCEVRGNPVPSYRW-LRN 64
Query: 63 GEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVL 122
G EI R+ +GT I S+ S Y C A N G I S++ ++
Sbjct: 65 GTEIDLESDYRYSLIDGTFII-----SNPSEAKDSGHYQCLATNTVGSILSREATLQFAY 119
Query: 123 REPYTVRVEDQKTMR-GNVAVFKCIIPS-SVEAYITVVSWEKDTVSLVSGSRFLITSTGA 180
++ R ++R G V C P S E + V E + RF+ TG
Sbjct: 120 LGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGN 179
Query: 181 LYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPA---NSAPSILDGFDHRKAM 237
LYI VQ D + +Y C+ ++ T S L + + P I F
Sbjct: 180 LYISKVQTSD-VGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTA 238
Query: 238 A-GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVS 296
A G V++ C ALG+P P W+K N + R +K+ L I N++ D+G Y C
Sbjct: 239 AKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAE 298
Query: 297 NRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNP 356
N G G+L V + GS + C TG W +NG L+P
Sbjct: 299 NSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSP 358
Query: 357 GKNVR-ITGINHENLIMDHMVKSDGGAYQCFV--RKDKLSAQDYVQVVLEDGTPKIISAF 413
V + G+ L++ ++ +SD G YQC + + A ++++ T +
Sbjct: 359 QSRVEMVNGV----LMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLK 414
Query: 414 SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISS 473
+V+ + V + C +G+P PTI+W D + + + RI+ I +G+ L I +
Sbjct: 415 KTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRE--NKRIA--ILPDGS----LRILN 466
Query: 474 SQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR-PMKNITAIAGRDTYIHCRVIGYPY 532
+ D G Y C N G A ++V+ P I K G ++C+ I
Sbjct: 467 ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDAS 526
Query: 533 YSIKWYKNSNLLPFNHRQV--------AFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLS 584
+ +Y P + + A ++ L + ++ + G Y C V S
Sbjct: 527 LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILL-MHAGRYGCRVQTTAD-S 584
Query: 585 TSQSVHVTVKVPP 597
S + V+ PP
Sbjct: 585 VSDEAELLVRGPP 597
Score = 70.9 bits (172), Expect = 1e-11
Identities = 231/1065 (21%), Positives = 387/1065 (36%), Gaps = 180/1065 (16%)
Query: 596 PPFIQPFE---FPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS 652
P F+Q + FP S ++V + C V +P + W ++G I ID T
Sbjct: 25 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVP-SYRWLRNGTEIDLESDYRYSLIDGT- 82
Query: 653 SLRISNLS-LMHNGNYTCIARNEAAAV-EHQSQLIVRVPPKFVVQPRDQDGIY-GKAVIL 709
ISN S +G+Y C+A N ++ ++ L F + R + G+ V+L
Sbjct: 83 -FIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVL 141
Query: 710 NCSAEGYPVPTIV--WKFSKGAGVPQFQPIALNGRIQVLSN-GSLLIKHVVEEDSGYYLC 766
CS + P I+ W F++ P F +A + R + G+L I V D G Y+C
Sbjct: 142 MCSPPPHS-PEIIYSWVFNE---FPSF--VAEDSRRFISQETGNLYISKVQTSDVGSYIC 195
Query: 767 KVSNDV--GADVSKSMYLTVKIPAMITSY--------PNTTLATQGQKKEMSCTAHGEKP 816
V N V +S LT++ ++ Y P T A +G +M C A G
Sbjct: 196 LVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPV 255
Query: 817 IIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRG 876
+ W K + I P AR S + L+I +D+G + C A NS G++
Sbjct: 256 PTITWMKVNGYI-PSKARLRKSQ--------AVLEIPNVQLDDAGIYECRAENSRGKNSF 306
Query: 877 IIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTK 936
QL V P E ++ D + D SP+ ECK + + K
Sbjct: 307 RGQLQVYTYPHWVE-KLNDTQ-----------LDSGSPLRW---ECKATGKPRPTYRWLK 351
Query: 937 D---VSPQ-----LNSATII-DIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD-- 985
+ +SPQ +N +I +++ S + A+N+ G S EL I A +AP
Sbjct: 352 NGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILA--SAPTFA 409
Query: 986 ----------GPPQEVHLE--PISSQSIRVTWK----APKKHLQNGIIRGYQIGYREYST 1029
QEV +E P S ++WK A +++ + I+ + S
Sbjct: 410 LNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK 469
Query: 1030 GGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPS 1089
++ + G +E+ L V+ R P E+ T E +
Sbjct: 470 SDEGKYVCRGENVFGSAEIIA----------SLSVKEPTRIELTPKRTEL--TVGESIVL 517
Query: 1090 YPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPS 1149
N +AI + ++ W TL + ++ + E G ++I S
Sbjct: 518 ----NCKAIHDASLDVTFYW-TLKGQPID--------------FEEEGGHFESIRAQASS 558
Query: 1150 LELDGLEKYTNYSIQVLAFTRAGD-GVRSEQIFTRTKEDV-------PGPPAGVKAAAAS 1201
+L I+ + AG G R + ++ PGPP V +
Sbjct: 559 ADL---------MIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPGIVIVEEIT 609
Query: 1202 ASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASP-----DSFSYRIPNLSRNRQ 1256
S +SW P + I Y + P+ + P D S +L+ +
Sbjct: 610 ESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVE 669
Query: 1257 YSVWVVAVTSAGRGNSSE----IITVEPLAK-APARILTFSGTVTTPWMKDIVLPCKAVG 1311
Y VVA G G+ S I T E + K AP + SG ++V+ + V
Sbjct: 670 YEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGR-----RHELVIAWEPVS 724
Query: 1312 D---------------PSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGY 1356
+ P+ W K+ T S + + I+ + S T G
Sbjct: 725 EEFQNGEGFGYIVAFRPNGTRGW-KEKMVTSS----EASKFIYRDESVPPLTPFEVKVGV 779
Query: 1357 YSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQY 1416
Y+ + + +I + + + + + + S I ++W +G+ + Y
Sbjct: 780 YNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESLGRPQGFEVGY 839
Query: 1417 SEDNSEQWGSFPISP--SERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474
+D ++ + + +E L L+ T Y FT+ A NG G G S + A T K
Sbjct: 840 WKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSA-TTKKS 898
Query: 1475 PQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVW------TTAQRTS 1528
P L ++V L GW P+ E G V+ + +Q
Sbjct: 899 PPSQAPSNLRWEQQGSQVSL---GWE----PVIPLANESEVVGYKVFYRQEGHSNSQVIE 951
Query: 1529 LSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTI 1573
K + L +A Y +++R + G + +Y G I
Sbjct: 952 TQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKI 996
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 232 bits (592), Expect = 2e-60
Identities = 243/1003 (24%), Positives = 412/1003 (41%), Gaps = 94/1003 (9%)
Query: 330 QVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK 389
+V L+C V G + W NG ++ G + R + + LI + D G YQC
Sbjct: 45 KVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATN 104
Query: 390 DK---LSAQDYVQVV-LEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLP-----TITW 440
+S + +Q L++ + S S V + + L+C P P + W
Sbjct: 105 SFGTIVSREAKLQFAYLDNFKTRTRSTVS---VRRGQGMVLLCG----PPPHSGELSYAW 157
Query: 441 TLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSA---------- 490
++ P + +SQ GN L I+ + D G Y C N+
Sbjct: 158 IFNEYPSYQDNRRFVSQ---ETGN----LYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPT 210
Query: 491 -------GVV-LYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSN 542
GV+ Y+ +I V+ P ++ K T + C +G P +I W + ++
Sbjct: 211 PLILRNDGVMGEYEPKIEVQFPETVPTAKGATV------KLECFALGNPVPTIIW-RRAD 263
Query: 543 LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPF 602
P + ++NG L++ + Q+E D G Y C + ++ P +IQ
Sbjct: 264 GKPIARKARRHKSNGILEIPNFQQE-DAGLYECVAENSRGKNVARGQLTFYAQPNWIQKI 322
Query: 603 EFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNLSL 661
++ + VF C P T W K+G P+ +T D I +L I+ ++L
Sbjct: 323 NDIHVAMEENVFWECKANGRPKP-TYKWLKNGEPL-----LTRDRIQIEQGTLNITIVNL 376
Query: 662 MHNGNYTCIARNEAAAVEHQSQL-IVRVPPKF--VVQPRDQDGIYGKAVILNCSAEGYPV 718
G Y C+A N+ + ++L ++ V P F + R G V++ C + P
Sbjct: 377 SDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPK 436
Query: 719 PTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSK 778
P WK KG + + N RI + +G+L I +V + D+G Y C +N G S
Sbjct: 437 PVYTWK--KGRDI-----LKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGT-ASS 488
Query: 779 SMYLTVKIPAMITSYPNTTLATQGQKKEMSC--TAHGEKPIIVRWEKEDRIIN----PEM 832
+ L VK P + P++ T G+ + C T I+ W +I+ +
Sbjct: 489 TGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDH 548
Query: 833 ARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPE-I 891
+ G+ +I +Q+ + +G + C S L V+ PP PPE +
Sbjct: 549 FERVGGQDSAGDLMIRNIQL-----KHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAV 603
Query: 892 EIKDVKARTITLRWTMGFDGNSPITGYDIECKNK-SDSWDSAQRTKD-VSPQLNSATIID 949
I ++ T L W G D +SPIT Y I+ + S W + + + + +AT++
Sbjct: 604 TIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVG 663
Query: 950 IHPSSTYSIRMYAKNRIGKSEPSNELTIT-ADEAAPDGPPQEVHLEPISSQSIRVTWKAP 1008
++P Y R A N IG EPS +EA P+ P V S + +TW+
Sbjct: 664 LNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETV 723
Query: 1009 KKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDN--LNKFTQYGLVVQA 1066
+ LQNG GY + +R Y +++V S D+ Y N ++ F+ + + V
Sbjct: 724 PEELQNGRGFGYVVAFRPYGK----MIWMLTVLASADASRYVFRNESVHPFSPFEVKVGV 779
Query: 1067 CNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRV 1126
N G GP S + + E+ P+ PP ++ A + S I + W++ E G +QG+ V
Sbjct: 780 FNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWAS-PLEKNRGRIQGYEV 838
Query: 1127 IYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKE 1186
YW + E Q S ++ L+ Y + V A+ AG G S + T++
Sbjct: 839 KYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRK 898
Query: 1187 DVPGPPAGVKAAAASASMVFVSW--LPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSF 1244
P P G +S S + ++W + L ++ Y V + S E + S
Sbjct: 899 PPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSV 958
Query: 1245 SYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPAR 1287
+P + Y + + + G G+SSE I + ++ A AR
Sbjct: 959 ELSLP---FDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYAR 998
Score = 165 bits (418), Expect = 4e-40
Identities = 215/916 (23%), Positives = 350/916 (38%), Gaps = 100/916 (10%)
Query: 419 SPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRD 478
S + V L C VKG P P I W L+ + G R S + EG S L + ++ +D
Sbjct: 41 SEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVV---EG---SLLINNPNKTQD 94
Query: 479 GGVYRCTANNSAGVV-----------LYQARINVRGPASIRPMKNITAIAGRDTYIHCRV 527
G Y+CTA NS G + L + R S+R + + + G H
Sbjct: 95 AGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPP--HSGE 152
Query: 528 IGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC---------NVL 578
+ Y W N ++R+ + G L ++ V+K D G YTC VL
Sbjct: 153 LSY-----AWIFNEYPSYQDNRRFVSQETGNLYIAKVEKS-DVGNYTCVVTNTVTNHKVL 206
Query: 579 VQPQLSTSQSVHVTVKVPPFIQPFEFPR---FSIGQRVFIPCVVVSGDLPITITWQK-DG 634
P ++ V + P I+ +FP + G V + C + +P TI W++ DG
Sbjct: 207 GPPTPLILRNDGVMGEYEPKIE-VQFPETVPTAKGATVKLECFALGNPVP-TIIWRRADG 264
Query: 635 RPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVV 694
+PI N L I N G Y C+A N + QL P ++
Sbjct: 265 KPIARKARRHKSN----GILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQ 320
Query: 695 QPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIK 754
+ D + V C A G P PT W + +P+ RIQ+ G+L I
Sbjct: 321 KINDIHVAMEENVFWECKANGRPKPTYKW-------LKNGEPLLTRDRIQI-EQGTLNIT 372
Query: 755 HVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMI--TSYPNTTLATQGQKKEMSCTAH 812
V D+G Y C N G S + + + T TL G + + C
Sbjct: 373 IVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPK 432
Query: 813 GEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYG 872
+ W K+ R I E R +S L+I+ + D+G ++C A N +G
Sbjct: 433 ASPKPVYTW-KKGRDILKENERITISED-------GNLRIINVTKSDAGSYTCIATNHFG 484
Query: 873 EDRGIIQLTVQE------PPDPPEIEIKD--------VKARTITLRWTMGFDGNSPITGY 918
L V++ PP ++ + + ++ + +T F+G+
Sbjct: 485 TASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDR 544
Query: 919 DIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTIT 978
D + + DSA I +I + + + + +L +
Sbjct: 545 DGDHFERVGGQDSA----------GDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIV- 593
Query: 979 ADEAAPDGPPQEVHLEPISSQSIRVTWK-APKKHLQNGIIRGYQIGYREYSTGGNFQFNI 1037
P GPP+ V ++ I+ + +++W+ P H I Y I R + G +
Sbjct: 594 ---RGPPGPPEAVTIDEITDTTAQLSWRPGPDNH---SPITMYVIQARTPFSVGWQAVST 647
Query: 1038 ISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQ 1096
+ G + T+ LN + +Y A N G G PS T E +P P NV
Sbjct: 648 VPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVS 707
Query: 1097 AIATSPESISISWSTLSKEALNGILQGFRVIYWA-NLMDGELGEIKNITTTQPSLELDGL 1155
S + I+W T+ +E NG G+ V + M L + + ++ + +
Sbjct: 708 GGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESV 767
Query: 1156 EKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP-GPPAGVKAAAASASMVFVSWLPPLK 1214
++ + ++V F G+G S + E+ P PPA + A + SA+ + V W PL+
Sbjct: 768 HPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLE 827
Query: 1215 LN-GIIRKYTV--FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGN 1271
N G I+ Y V + + + S +I NL + Y + V A SAG G
Sbjct: 828 KNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGP 887
Query: 1272 SSEIITVEPLAKAPAR 1287
SS + V P++
Sbjct: 888 SSATVNVTTRKPPPSQ 903
Score = 133 bits (335), Expect = 2e-30
Identities = 146/566 (25%), Positives = 232/566 (40%), Gaps = 60/566 (10%)
Query: 240 QRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVT--GLLIENI-RPSDSGSYVCEVS 296
++V+L C+ G+P+P RW + ++ F+ +V LLI N + D+G+Y C +
Sbjct: 44 KKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTAT 103
Query: 297 NRYGTAKVIGR------LYV---KQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQ-ELS 346
N +GT ++ R Y+ K ++T+S R+ G + L C + +
Sbjct: 104 NSFGT--IVSREAKLQFAYLDNFKTRTRSTVSVRR-----GQGMVLLCGPPPHSGELSYA 156
Query: 347 WYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKD----KLSAQDYVQVVL 402
W N E + N R NL + + KSD G Y C V K+ ++
Sbjct: 157 WIFN-EYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILR 215
Query: 403 EDGT-----PKIISAFSEKV-VSPAEPVSLMCNVKGTPLPTITWT-LDDDPILKGGSHRI 455
DG PKI F E V + V L C G P+PTI W D PI +
Sbjct: 216 NDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHK 275
Query: 456 SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNIT 514
S I L I + Q D G+Y C A NS G + + ++ P I+ + +I
Sbjct: 276 SNGI---------LEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIH 326
Query: 515 AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYT 574
+ + C+ G P + KW KN P R GTL ++ V D G Y
Sbjct: 327 VAMEENVFWECKANGRPKPTYKWLKNGE--PLLTRDRIQIEQGTLNITIVNLS-DAGMYQ 383
Query: 575 CNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFS---IGQRVFIPCVVVSGDLPITITWQ 631
C + + S + + V P R + +G V I C + P+ TW+
Sbjct: 384 CLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPV-YTWK 442
Query: 632 KDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPK 691
K + + +TI +LRI N++ G+YTCIA N L+V+ P +
Sbjct: 443 KGRDILKENERITISE---DGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTR 499
Query: 692 FVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIA-----LNGRIQVL 746
+V P D G++++L C IV+ +S + F + G+
Sbjct: 500 VMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQD--- 556
Query: 747 SNGSLLIKHVVEEDSGYYLCKVSNDV 772
S G L+I+++ + +G Y+C V V
Sbjct: 557 SAGDLMIRNIQLKHAGKYVCMVQTSV 582
Score = 111 bits (278), Expect = 6e-24
Identities = 148/616 (24%), Positives = 237/616 (38%), Gaps = 49/616 (7%)
Query: 6 LSLFQSFANVFSED--LHSSLYFVNASLQEVVF---ASTTGTLVPCPAAGIPPVTLRWYL 60
L + QSF ++D LH ++ S V+F + + C G P +RW L
Sbjct: 7 LLVLQSFILCLADDSTLHGPIFIQEPS--PVMFPLDSEEKKVKLNCEVKGNPKPHIRWKL 64
Query: 61 ATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKA 120
G ++ R+ G+L I ++ + TY CTA N G I S++ ++
Sbjct: 65 -NGTDVDTGMDFRYSVVEGSLLI-----NNPNKTQDAGTYQCTATNSFGTIVSREAKLQF 118
Query: 121 VLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGA 180
+ + R ++R + P ++ + S RF+ TG
Sbjct: 119 AYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGN 178
Query: 181 LYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDP---ANSAPSILDGFDHRKAM 237
LYI V+ D + NY C+ + T L + + P I F
Sbjct: 179 LYIAKVEKSD-VGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPT 237
Query: 238 A-GQRVELPCKALGHPEPDYRWLK-DNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEV 295
A G V+L C ALG+P P W + D P+ R K+ L I N + D+G Y C
Sbjct: 238 AKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVA 297
Query: 296 SNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILN 355
N G G+L + ++ V C G W +NGE L
Sbjct: 298 ENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLL 357
Query: 356 PGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDK----LSAQDYVQVVLEDGTPKIIS 411
++ I L + + SD G YQC +A+ V V D + ++
Sbjct: 358 TRDRIQ---IEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLK 414
Query: 412 AFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNI 471
+ +V V + C K +P P TW D ILK + RI+ I+ +GN + +N+
Sbjct: 415 RVT--LVKVGGEVVIECKPKASPKPVYTWKKGRD-ILK-ENERIT--ISEDGN-LRIINV 467
Query: 472 SSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIR-PMKNITAIAGRDTYIHCRVIGY 530
+ S D G Y C A N G + V+ P + P ++ G + C+V
Sbjct: 468 TKS---DAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHD 524
Query: 531 PYYSI--KWYKNSNLLPFNHRQVAFE------NNGTLKLSDVQKEVDEGEYTCNVLVQPQ 582
I W N +L+ F+ FE + G L + ++Q + G+Y C +VQ
Sbjct: 525 HSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK-HAGKYVC--MVQTS 581
Query: 583 LS-TSQSVHVTVKVPP 597
+ S + + V+ PP
Sbjct: 582 VDRLSAAADLIVRGPP 597
Score = 84.3 bits (207), Expect = 1e-15
Identities = 99/395 (25%), Positives = 163/395 (41%), Gaps = 34/395 (8%)
Query: 33 EVVFASTTGTL------VPCPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPF 86
EV F T T + C A G P T+ W A G+ I R NG L+I F
Sbjct: 228 EVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPI--ARKARRHKSNGILEIPNF 285
Query: 87 PPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMRGNVAVFKCI 146
Y C AEN GK ++ + + + ++ D ++C
Sbjct: 286 QQEDAGL------YECVAENSRGKNVARG-QLTFYAQPNWIQKINDIHVAMEENVFWECK 338
Query: 147 IPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGE 206
+ W K+ L++ R I G L I V D Y+C+ +++
Sbjct: 339 ANGRPKP---TYKWLKNGEPLLTRDRIQIEQ-GTLNITIVNLSDAGM-YQCLAENKHG-- 391
Query: 207 TRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
SN+ ++ + + ++L K G V + CK P+P Y W K L+
Sbjct: 392 VIFSNAELSVIAVGPDFSRTLLKRVTLVKV--GGEVVIECKPKASPKPVYTWKKGRDILK 449
Query: 267 LSGRFQKTVTG-LLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKS 325
+ R + G L I N+ SD+GSY C +N +GTA G L VK P + + P +
Sbjct: 450 ENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDV 509
Query: 326 SVGSQVSLSCSVTGTEDQEL--SWYRNGEILNPGKN----VRITGINHE-NLIMDHMVKS 378
+VG + L C VT ++ +W NG +++ ++ R+ G + +L++ ++
Sbjct: 510 TVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLK 569
Query: 379 DGGAYQCFVRK--DKLSAQDYVQVVLEDGTPKIIS 411
G Y C V+ D+LSA + V G P+ ++
Sbjct: 570 HAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVT 604
Score = 67.8 bits (164), Expect = 1e-10
Identities = 197/956 (20%), Positives = 331/956 (34%), Gaps = 148/956 (15%)
Query: 592 TVKVPPFIQ---PFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNI 648
T+ P FIQ P FP S ++V + C V P I W+ +G + + +
Sbjct: 22 TLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKP-HIRWKLNGTDVDTGMDFRYSVV 80
Query: 649 DFTSSLRISNLSLMHN-GNYTCIARNE-AAAVEHQSQLIVRVPPKFVVQPRDQDGIY-GK 705
+ SL I+N + + G Y C A N V +++L F + R + G+
Sbjct: 81 E--GSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQ 138
Query: 706 AVILNCSAEGYPVP-TIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYY 764
++L C + + W F++ P +Q N R G+L I V + D G Y
Sbjct: 139 GMVLLCGPPPHSGELSYAWIFNE---YPSYQD---NRRFVSQETGNLYIAKVEKSDVGNY 192
Query: 765 LCKVSNDVGAD----------VSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGE 814
C V+N V + + P + +P T +G ++ C A G
Sbjct: 193 TCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGN 252
Query: 815 KPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGED 874
+ W + D +AR K G I Q +ED+G + C A NS G++
Sbjct: 253 PVPTIIWRRAD---GKPIARKARRHKSNGILEIPNFQ-----QEDAGLYECVAENSRGKN 304
Query: 875 RGIIQLTVQEPPDPPEIEIKDVK-ARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQ 933
QLT P+ + +I D+ A + W +G T + + +
Sbjct: 305 VARGQLTFYAQPNWIQ-KINDIHVAMEENVFWECKANGRPKPT---YKWLKNGEPLLTRD 360
Query: 934 RTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD-------- 985
R + LN TI+++ + Y + A+N+ G + EL++ A PD
Sbjct: 361 RIQIEQGTLN-ITIVNLSDAGMY--QCLAENKHGVIFSNAELSVIA--VGPDFSRTLLKR 415
Query: 986 ------GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIIS 1039
G + +P +S TWK + L+ + + II+
Sbjct: 416 VTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKEN---------ERITISEDGNLRIIN 466
Query: 1040 VDTSGDSEVYTLDNLNKF----TQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENV 1095
V T D+ YT N F + LVV+ R PSS ++ +P
Sbjct: 467 V-TKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPC------ 519
Query: 1096 QAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGL 1155
Q I +WS NG L F DG+ E + G
Sbjct: 520 QVTHDHSLDIVFTWS------FNGHLIDFD-------RDGDHFE-----------RVGGQ 555
Query: 1156 EKYTNYSIQVLAFTRAGDGV--------RSEQIFTRTKEDVPGPPAGVKAAAASASMVFV 1207
+ + I+ + AG V R PGPP V + + +
Sbjct: 556 DSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQL 615
Query: 1208 SWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPD-----SFSYRIPNLSRNRQYSVWVV 1262
SW P + I Y + P+ P+ +F+ + L+ +Y V
Sbjct: 616 SWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTV 675
Query: 1263 AVTSAGRGN----SSEIITVEPLAKA-PARILTFSGTVTTPWMKDIVLPCKAVGD----- 1312
A G G S + T E L + PA + G+ + ++V+ + V +
Sbjct: 676 AANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKS-----ELVITWETVPEELQNG 730
Query: 1313 ----------PSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
P + WM L + D R +F N S + G ++
Sbjct: 731 RGFGYVVAFRPYGKMIWM-----LTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGE 785
Query: 1363 NNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWL-PGDNGGSSIRGYILQY--SED 1419
+ ++ + + + + +++ I + W P + I+GY ++Y ED
Sbjct: 786 GPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHED 845
Query: 1420 NSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEP 1475
E ++ S ++ NLK Y + A N G G S + T P
Sbjct: 846 KEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPP 901
Score = 66.6 bits (161), Expect = 2e-10
Identities = 76/335 (22%), Positives = 134/335 (40%), Gaps = 39/335 (11%)
Query: 1247 RIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLP 1306
RI N++++ S +A G +S+ + V K P R++ ++ + IVLP
Sbjct: 463 RIINVTKSDAGSYTCIATNHFGTASSTGNLVV----KDPTRVMVPPSSMDVTVGESIVLP 518
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIF-------SNGSFIIRTVKAEDSGYYSC 1359
C+ D S + + NG L+ D F S G +IR ++ + +G Y C
Sbjct: 519 CQVTHDHSLDIVFTWSFNG--HLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVC 576
Query: 1360 IANNNWGSDEIILNLQVQVPPDQPR-LTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSE 1418
+ + +L V+ PP P +T+ + T ++ LSW PG + S I Y++Q
Sbjct: 577 MVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQART 636
Query: 1419 DNSEQWGSFPISP---SERSYRLENLKCGTW--YKFTLTAQNGVG---PGRISE------ 1464
S W + P +++ + W Y+F A N +G P R SE
Sbjct: 637 PFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEE 696
Query: 1465 -IIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTT 1523
+ E + EL + T L N G + + +RP+G +W
Sbjct: 697 ALPEVTPANVSGGGGSKSELVITWETVPEELQ----NGRG---FGYVVAFRPYGKMIWML 749
Query: 1524 AQRTSLSKSYILY---DLQEATWYELQMRVCNSAG 1555
S S ++ + + +E+++ V N+ G
Sbjct: 750 TVLASADASRYVFRNESVHPFSPFEVKVGVFNNKG 784
Score = 51.2 bits (121), Expect = 1e-05
Identities = 62/269 (23%), Positives = 104/269 (38%), Gaps = 40/269 (14%)
Query: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
++V+ CK P P W K + ++ + R +I +G+ I V D+G Y+CIA
Sbjct: 424 EVVIECKPKASPKPVYTWKKGRD----ILKENERITISEDGNLRIINVTKSDAGSYTCIA 479
Query: 1362 NNNWGSDEIILNL------QVQVPPDQPRLTVSKTT----------SSSITLSWLPGDNG 1405
N++G+ NL +V VPP +TV ++ S I +W
Sbjct: 480 TNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTW------ 533
Query: 1406 GSSIRGYILQYSEDNS--EQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRIS 1463
S G+++ + D E+ G S + N++ K+ Q V R+S
Sbjct: 534 --SFNGHLIDFDRDGDHFERVGG---QDSAGDLMIRNIQLKHAGKYVCMVQTSV--DRLS 586
Query: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYR-PF--GTTV 1520
A + + P E I T +L+ D PIT + ++ R PF G
Sbjct: 587 --AAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA 644
Query: 1521 WTTAQRTSLSKSYILYDLQEATWYELQMR 1549
+T K++ + W E + R
Sbjct: 645 VSTVPELIDGKTFTATVVGLNPWVEYEFR 673
>gi|4827022 contactin 2 precursor [Homo sapiens]
Length = 1040
Score = 231 bits (590), Expect = 4e-60
Identities = 235/956 (24%), Positives = 380/956 (39%), Gaps = 87/956 (9%)
Query: 296 SNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEI-- 353
S+ G+ G ++ QPL + S QV L+C + W NG
Sbjct: 26 SSALGSQTTFGPVFEDQPLSVLFP----EESTEEQVLLACRARASPPATYRWKMNGTEMK 81
Query: 354 LNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAF 413
L PG ++ G N +IM+ D G YQC + + + +L G + F
Sbjct: 82 LEPGSRHQLVGGNL--VIMNPTKAQDAGVYQCLA-SNPVGTVVSREAILRFG---FLQEF 135
Query: 414 SEKVVSPAEP-----VSLMCNVKGT-PLPTITWTLDDDP--ILKGGSHRISQMITSEGNV 465
S++ P + V L CN P + W L++ P I G H +SQ + GN
Sbjct: 136 SKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQ---TTGN- 191
Query: 466 VSYLNISSSQVRDGGVYRCTANN-------------------SAGVVLYQARINVRGPAS 506
L I+ + D G Y C A + + L+ I R PA
Sbjct: 192 ---LYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAE 248
Query: 507 IRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQK 566
A+ G+ + C G P IKW K L TL++ V
Sbjct: 249 TY------ALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTA----EPTLQIPSVSF 298
Query: 567 EVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPI 626
E DEG Y C T Q + P +++ IG + C P
Sbjct: 299 E-DEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRP- 356
Query: 627 TITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV 686
T+ W ++G P+ V + LR S LSL +G Y C+A N+ + ++L V
Sbjct: 357 TVRWLRNGEPLASQNRVEV----LAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAV 412
Query: 687 R-VPPKFVVQP--RDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRI 743
+ + P F + P R G +++ C P ++W SKG + + + R+
Sbjct: 413 QALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLW--SKGTEI-----LVNSSRV 465
Query: 744 QVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQ 803
V +G+L+I+++ D G Y C N +G S + L+V+ IT P++ G
Sbjct: 466 TVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGI-LSVRDATKITLAPSSADINLGD 524
Query: 804 KKEMSCTAHGEKP--IIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSG 861
+ C A + + W +D I+ + V +E I L IL G
Sbjct: 525 NLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNV-KETIGDLTILNAQLRHGG 583
Query: 862 FFSCHAINSYGEDRGIIQLTVQEPPDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDI 920
++C A + V+ PP PP + ++D+ TI L W+ GFD +SPI Y +
Sbjct: 584 KYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTL 643
Query: 921 ECKNKSDSWDSAQRTKDVSPQLNSAT--IIDIHPSSTYSIRMYAKNRIGKSEPSNELT-I 977
+ + RT + + N+ T ++ + P Y R+ A N +G EPS + I
Sbjct: 644 QARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKI 703
Query: 978 TADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNI 1037
EAAP P + + + V W + QNG GY + +R G+ +
Sbjct: 704 RTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQ---GSTHWQT 760
Query: 1038 ISVDTSGDSE--VYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENV 1095
V D++ VY+ +++ +T + + +++ NR G GP S + + E+ P P V
Sbjct: 761 ARVP-GADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKV 819
Query: 1096 QAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGL 1155
A S ++++W + ++ +NGIL G+ + YW + S + GL
Sbjct: 820 WAKGVSSSEMNVTWEPVQQD-MNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGL 878
Query: 1156 EKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLP 1211
T Y + V A+ RAG G S T + P P G + S+S + + W P
Sbjct: 879 HPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDP 934
Score = 165 bits (417), Expect = 5e-40
Identities = 224/942 (23%), Positives = 363/942 (38%), Gaps = 102/942 (10%)
Query: 392 LSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPI-LKG 450
L +Q V ED ++ F E+ S E V L C + +P T W ++ + L+
Sbjct: 29 LGSQTTFGPVFEDQPLSVL--FPEE--STEEQVLLACRARASPPATYRWKMNGTEMKLEP 84
Query: 451 GSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG---PASI 507
GS Q++ GN+V ++ ++ +D GVY+C A+N G V+ + I G S
Sbjct: 85 GSRH--QLVG--GNLVI---MNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSK 137
Query: 508 RPMKNITAIAGRDTYIHCRVIG-YPYYSIKWYKNS--NLLPFNHRQVAFENNGTLKLSDV 564
+ A G + C YP S +W N N +P + R + G L ++
Sbjct: 138 EERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIART 197
Query: 565 QKEVDEGEYTCNVLVQPQLSTSQ------SVHVTVKVPPFIQPFEFPRFS------IGQR 612
D G Y+C ST +++ + P RF +GQ+
Sbjct: 198 NAS-DLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQ 256
Query: 613 VFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIAR 672
V + C +P I W+K + GSL + T L+I ++S G Y C A
Sbjct: 257 VTLECFAFGNPVP-RIKWRK----VDGSLSPQWTTAEPT--LQIPSVSFEDEGTYECEAE 309
Query: 673 NEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP 732
N Q ++IV+ P+++ D + G + C+A G P PT+ W +
Sbjct: 310 NSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRW-------LR 362
Query: 733 QFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPA---M 789
+P+A R++VL+ G L + EDSG Y C N G + S L V+ A
Sbjct: 363 NGEPLASQNRVEVLA-GDLRFSKLSLEDSGMYQCVAENKHGT-IYASAELAVQALAPDFR 420
Query: 790 ITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVIST 849
+ A +G + + C +V W K I LV++ V T
Sbjct: 421 LNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEI--------LVNSSRVTVTPDGT 472
Query: 850 LQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQE------PPDPPEIEIKDVKARTITL 903
L I R D G ++C A N G+ L+V++ P +I + D +TL
Sbjct: 473 LIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGD----NLTL 528
Query: 904 RWTMGFDGNSPIT------GYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYS 957
+ D +T + I+ D R +V + TI++
Sbjct: 529 QCHASHDPTMDLTFTWTLDDFPID----FDKPGGHYRRTNVKETIGDLTILNAQLRHGGK 584
Query: 958 IRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGII 1017
A+ + + S E T+ P GPP V + I +I+++W + + I
Sbjct: 585 YTCMAQTVVDSA--SKEATVLV--RGPPGPPGGVVVRDIGDTTIQLSWS--RGFDNHSPI 638
Query: 1018 RGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSS 1076
Y + R G Q + G++E + L + Y V A N GTG PS
Sbjct: 639 AKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSG 698
Query: 1077 QEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGE 1136
T E PS P + +P + ++W+ +S+E NG GF + L
Sbjct: 699 PSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNG--DGFGYL----LSFRR 752
Query: 1137 LGEIKNITTTQPSLEL-------DGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP 1189
G T P + + + YT + +++ ++ R GDG S + E+ P
Sbjct: 753 QGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEP 812
Query: 1190 G-PPAGVKAAAASASMVFVSWLPPLK-LNGIIRKYTV--FCSHPYPTVISEFEASPDSFS 1245
P V A S+S + V+W P + +NGI+ Y + + + + S
Sbjct: 813 RVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTS 872
Query: 1246 YRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPAR 1287
R+ L N +Y V V A AG G +S + P R
Sbjct: 873 ARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRR 914
Score = 154 bits (388), Expect = 1e-36
Identities = 233/988 (23%), Positives = 373/988 (37%), Gaps = 94/988 (9%)
Query: 240 QRVELPCKALGHPEPDYRWLKDN--MPLELSGRFQKTVTGLLIEN-IRPSDSGSYVCEVS 296
++V L C+A P YRW + M LE R Q L+I N + D+G Y C S
Sbjct: 55 EQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLAS 114
Query: 297 NRYGTA----KVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGT-EDQELSWYRNG 351
N GT ++ ++++ K P VK+ G V L C+ W N
Sbjct: 115 NPVGTVVSREAILRFGFLQEFSKEERDP--VKAHEGWGVMLPCNPPAHYPGLSYRWLLN- 171
Query: 352 EILN--PGKNVRITGINHENLIMDHMVKSDGGAYQC-------FVRKDKLSAQDYVQVVL 402
E N P NL + SD G Y C F K S + +
Sbjct: 172 EFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAA 231
Query: 403 EDG---TPKIISAF-SEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQM 458
ED P I + F +E + V+L C G P+P I W D + Q
Sbjct: 232 EDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSP-------QW 284
Query: 459 ITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNITAIA 517
T+E L I S D G Y C A NS G Q RI V+ P ++ + + A
Sbjct: 285 TTAEPT----LQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADI 340
Query: 518 GRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC-- 575
G + C G P +++W +N L +R G L+ S + E D G Y C
Sbjct: 341 GSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLA--GDLRFSKLSLE-DSGMYQCVA 397
Query: 576 -----NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 630
+ +L+ Q++ ++ P + R G + IPC + + + W
Sbjct: 398 ENKHGTIYASAELAV-QALAPDFRLNPVRRLIPAAR---GGEILIPCQPRAAPKAVVL-W 452
Query: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
K + S VT+ +L I N+S G YTC A N L VR
Sbjct: 453 SKGTEILVNSSRVTVTP---DGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDAT 509
Query: 691 KFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQF-QPIALNGRIQVLSN- 748
K + P D G + L C A P + + ++ F +P R V
Sbjct: 510 KITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETI 569
Query: 749 GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIP------AMITSYPNTTLATQG 802
G L I + G Y C V + SK + V+ P ++ +TT+
Sbjct: 570 GDLTILNAQLRHGGKYTCMAQTVVDS-ASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSW 628
Query: 803 QK------KEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV 856
+ T P +W++ R + E E L + P +
Sbjct: 629 SRGFDNHSPIAKYTLQARTPPAGKWKQ---------VRTNPANIEGNAETAQVLGLTPWM 679
Query: 857 REDSGFFSCHAINSYGEDRGIIQL--TVQEPPD--PPEIEIKDVKARTITLRWT-MGFD- 910
+ + + + + GE G T + P P + + + WT M +
Sbjct: 680 DYEFRVIASNILGT-GEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREY 738
Query: 911 GNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSE 970
N GY + + + + R Q + + P + + +++ + NR G
Sbjct: 739 QNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGP 798
Query: 971 PSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTG 1030
S + + E P P +V + +SS + VTW+ P + NGI+ GY+I Y +
Sbjct: 799 ESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWE-PVQQDMNGILLGYEIRYWK---A 854
Query: 1031 GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSY 1090
G+ + V T+G + L+ T+Y + V+A NRAGTGP+S TT++ P
Sbjct: 855 GDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRR 914
Query: 1091 PPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSL 1150
PP N+ + S S+SI W + + G++++Y +L L ++ T + +
Sbjct: 915 PPGNI-SWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDL---HLTPTLHL-TGKNWI 969
Query: 1151 ELDGLEKYTNYSIQVLAFTRAGDGVRSE 1178
E+ E + +Q+ GDG+ +E
Sbjct: 970 EIPVPEDIGHALVQIRTTGPGGDGIPAE 997
Score = 124 bits (310), Expect = 1e-27
Identities = 154/624 (24%), Positives = 236/624 (37%), Gaps = 68/624 (10%)
Query: 2 WILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLA 61
W AL +F VF ED S+ F S +E V L+ C A PP T RW +
Sbjct: 25 WSSALGSQTTFGPVF-EDQPLSVLFPEESTEEQV-------LLACRARASPPATYRWKM- 75
Query: 62 TGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHD-NTYYCTAENPSGKIRSQDVHIKA 120
G E+ PG RH G L I T D Y C A NP G + S++ ++
Sbjct: 76 NGTEMKLEPGSRHQLVGGNLVIMN------PTKAQDAGVYQCLASNPVGTVVSREAILRF 129
Query: 121 VLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSW-----EKDTVSLVSGSRFLI 175
+ ++ D V ++P + A+ +S+ E G F+
Sbjct: 130 GFLQEFSKEERDPVKAHEGWGV---MLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVS 186
Query: 176 TSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA----RLFVSDPANSAPSILDGF 231
+TG LYI D L NY C+ T+ S L D APSI F
Sbjct: 187 QTTGNLYIARTNASD-LGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARF 245
Query: 232 DHRK-AMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGS 290
A+ GQ+V L C A G+P P +W K + LS ++ L I ++ D G+
Sbjct: 246 PAETYALVGQQVTLECFAFGNPVPRIKWRK--VDGSLSPQWTTAEPTLQIPSVSFEDEGT 303
Query: 291 YVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRN 350
Y CE N G V GR+ V+ + ++ +GS + C+ G + W RN
Sbjct: 304 YECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRN 363
Query: 351 GEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKII 410
GE L V + +L + D G YQC + ++ ++ P
Sbjct: 364 GEPLASQNRVEVLA---GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFR 420
Query: 411 SAFSEKVVSPAE--PVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSY 468
+++ A + + C + P + W+ + ++ S R++ +T +G ++
Sbjct: 421 LNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILV--NSSRVT--VTPDGTLI-I 475
Query: 469 LNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAI-------AGRDT 521
NIS S D G Y C A N + + N G S+R IT G +
Sbjct: 476 RNISRS---DEGKYTCFAEN------FMGKANSTGILSVRDATKITLAPSSADINLGDNL 526
Query: 522 YIHCRVIGYPYYSIKWYKNSNLLPFN--------HRQVAFENNGTLKLSDVQKEVDEGEY 573
+ C P + + + P + R E G L + + Q G+Y
Sbjct: 527 TLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLR-HGGKY 585
Query: 574 TCNVLVQPQLSTSQSVHVTVKVPP 597
TC S S+ V V+ PP
Sbjct: 586 TCMAQTVVD-SASKEATVLVRGPP 608
Score = 44.3 bits (103), Expect = 0.001
Identities = 29/100 (29%), Positives = 42/100 (42%), Gaps = 9/100 (9%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMK-DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSC 1359
+ + L C A G+P P +KW K D + +P T + I S V ED G Y C
Sbjct: 255 QQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPS--------VSFEDEGTYEC 306
Query: 1360 IANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSW 1399
A N+ G D + + VQ P+ ++ L W
Sbjct: 307 EAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRW 346
Score = 43.1 bits (100), Expect = 0.003
Identities = 33/103 (32%), Positives = 50/103 (48%), Gaps = 12/103 (11%)
Query: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIA 1361
+I++PC+ P V W K GT LV R ++ +G+ IIR + D G Y+C A
Sbjct: 435 EILIPCQPRAAPKAVVLWSK---GTEILVN-SSRVTVTPDGTLIIRNISRSDEGKYTCFA 490
Query: 1362 NNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDN 1404
N G L V+ D ++T++ +S+ I L GDN
Sbjct: 491 ENFMGKANSTGILSVR---DATKITLA-PSSADINL----GDN 525
Score = 41.2 bits (95), Expect = 0.010
Identities = 26/76 (34%), Positives = 36/76 (47%), Gaps = 6/76 (7%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C A G P P V+W++ NG P + R + + G + EDSG Y C+A N G
Sbjct: 348 CAAAGKPRPTVRWLR--NGEP--LASQNRVEVLA-GDLRFSKLSLEDSGMYQCVAENKHG 402
Query: 1367 SDEIILNLQVQ-VPPD 1381
+ L VQ + PD
Sbjct: 403 TIYASAELAVQALAPD 418
Score = 40.0 bits (92), Expect = 0.023
Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 2/67 (2%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCI 1360
+ ++L C+A P +W NGT + R + I+ KA+D+G Y C+
Sbjct: 55 EQVLLACRARASPPATYRWKM--NGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCL 112
Query: 1361 ANNNWGS 1367
A+N G+
Sbjct: 113 ASNPVGT 119
Score = 33.9 bits (76), Expect = 1.7
Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 4/64 (6%)
Query: 1303 IVLPCKAVGD-PSPAVKWMKDSNGTPSLVTIDGRRSIF-SNGSFIIRTVKAEDSGYYSCI 1360
++LPC P + +W+ N P+ + DGR + + G+ I A D G YSC+
Sbjct: 151 VMLPCNPPAHYPGLSYRWLL--NEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCL 208
Query: 1361 ANNN 1364
A ++
Sbjct: 209 ATSH 212
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 229 bits (585), Expect = 2e-59
Identities = 261/981 (26%), Positives = 401/981 (40%), Gaps = 143/981 (14%)
Query: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--------TLDDDPILKGGSHR 454
ED P+I+ S+ +VS EP +L C +G P PTI W T DDP SHR
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDP----RSHR 80
Query: 455 ISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRP 509
M+ G++ + + R D GVY C A N G V + A + V R P
Sbjct: 81 ---MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 510 MKNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568
+ A+ G + C+ G+P +I W K+ + L ++ G L ++ +K
Sbjct: 138 SDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKS- 194
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTV-KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
D G+Y C S+ +TV + P F++ ++ C +P T
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-T 253
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
+ W+KD +P S D+ +L+I ++ G+YTC+A N E + L V+
Sbjct: 254 VRWRKDDGELPKSRYEIRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Query: 688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP-QFQPIALNGRIQVL 746
PP FVV+PRDQ G+ V C A G P P I W+ + +QP + R V
Sbjct: 310 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 369
Query: 747 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV------KIPAMITSYP-NTTLA 799
G L I +V D GYY+C+ N G+ ++K+ YL V + P +I P N T+A
Sbjct: 370 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKA-YLEVTDVIADRPPPVIRQGPVNQTVA 428
Query: 800 TQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED 859
G +SC A G + W K+ +++ + +R + E G LQI D
Sbjct: 429 VDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENG-----VLQIRYAKLGD 480
Query: 860 SGFFSCHAINSYGEDRGIIQLTVQE----------------PPDPPEIEIKDVKARTITL 903
+G ++C A GE + VQE P P + E+ DV T+TL
Sbjct: 481 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 540
Query: 904 RWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAK 963
W + + T Y IE + + S+ +T + + ++ I + P++ Y + A
Sbjct: 541 SWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLVRAA 598
Query: 964 NRIGKSEPSN-ELTITADEAAPDGPPQE------------VHLE---PISSQSIRVTWKA 1007
N G S+PS + + P + +HL +SS SI V W
Sbjct: 599 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 658
Query: 1008 PKKHLQNGIIRGYQIGYREYSTG-GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQA 1066
+ Q+ I+GY+I YR G + + V T + V + +L K Y + +
Sbjct: 659 DQ---QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARP 714
Query: 1067 CNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT--SPESISISWSTLSKEALNGILQGF 1124
G S+ TLE+ PS PP+ V + +I +SW ++ NG++Q +
Sbjct: 715 FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 774
Query: 1125 RVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRT 1184
+V W + K + + S+ + L YS++V A T AG GV+SE F +
Sbjct: 775 KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 832
Query: 1185 KEDVPGPP-----------------------AGVKAAAASASMVFVSWL--PPLKLNGI- 1218
D G P AG+ AA MVF WL K NG+
Sbjct: 833 --DAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLT 890
Query: 1219 -----IRKYTVFCSHPYPTV-----------------ISEFEASPDSFSYRIPNLSRNRQ 1256
IRK F P T ISE A P + PN N
Sbjct: 891 STYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQP-WLADTWPNTGNN-- 947
Query: 1257 YSVWVVAVTSAGRGNSSEIIT 1277
++ ++ +AG GNS +T
Sbjct: 948 HNDCSISCCTAGNGNSDSNLT 968
Score = 127 bits (319), Expect = 1e-28
Identities = 193/853 (22%), Positives = 335/853 (39%), Gaps = 105/853 (12%)
Query: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
P + P + S G +L+C G + WY+ GE + K+ +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQV-VLEDGTPKIISAFSEKVVSP 420
+ ++ + D G Y C R + +S ++V +L D S+ +V+
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVMVAV 144
Query: 421 AEPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
EP + C +G P PTI+W D P+ + IT G L I+ ++ D
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL-----DDKDERITIRG---GKLMITYTRKSDA 196
Query: 480 GVYRCTANNSAGVVLYQ-ARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKW 537
G Y C N G + A + V P+ ++ N+ C G P +++W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 538 YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597
K+ LP + ++ ++ TLK+ V D G YTC V S +TV+ PP
Sbjct: 257 RKDDGELPKSRYEI--RDDHTLKIRKVTAG-DMGSYTC-VAENMVGKAEASATLTVQEPP 312
Query: 598 -FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG--------RPIPGSLGVTIDNI 648
F+ ++G+ V C P I W+++G +P S ++
Sbjct: 313 HFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQ- 370
Query: 649 DFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQDGI 702
T L I+N+ G Y C N A ++ ++ L V R PP P +Q
Sbjct: 371 --TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 428
Query: 703 YGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSG 762
+L+C A G PVPTI+W+ K + Q + RI+ L NG L I++ D+G
Sbjct: 429 VDGTFVLSCVATGSPVPTILWR--KDGVLVSTQ----DSRIKQLENGVLQIRYAKLGDTG 482
Query: 763 YYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTT----LATQGQKKEMSCTAHGEKPII 818
Y C S G + + S Y+ V+ + P T + + K E+ T +
Sbjct: 483 RYTCIASTPSG-EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNTVT 539
Query: 819 VRWEKE--------DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-FSCHAIN 869
+ W+ II S + V E V + + ++ ++ + F A N
Sbjct: 540 LSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAAN 599
Query: 870 SYG------------------EDRGIIQLTVQEPPDPPEIEIKD---VKARTITLRWTMG 908
+YG +G+ VQ + + + + + +I + WT+
Sbjct: 600 AYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD 659
Query: 909 FDGNSPITGYDIECK-NKSDSWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYA-KNR 965
+ I GY I + + ++ +S +V +P NS I D+ Y I+ N
Sbjct: 660 -QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNE 718
Query: 966 IGKSEPSNELTITADEAAPDGPPQEVHLEPI--SSQSIRVTWKAPKKHLQNGIIRGYQIG 1023
++ + T +E AP PPQ V + + +I V+W+ P + QNG+++ Y++
Sbjct: 719 FQGADSEIKFAKTLEE-APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV- 776
Query: 1024 YREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ-EIITT 1082
+ G +++ I+ G + + L +Y + V A AG+G S+ + I
Sbjct: 777 ---WCLGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 832
Query: 1083 TLEDVPSYPPENV 1095
P P + V
Sbjct: 833 DAHGNPVSPEDQV 845
Score = 122 bits (307), Expect = 3e-27
Identities = 129/487 (26%), Positives = 194/487 (39%), Gaps = 62/487 (12%)
Query: 46 CPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPPSSFSTLIH----- 96
C A G P T+ WY GE + D R + P+G+L F ++H
Sbjct: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLPSGSL--------FFLRIVHGRKSR 100
Query: 97 --DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEA 153
+ Y C A N G+ S + ++ A+LR+ + D G AV +C P
Sbjct: 101 PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE 160
Query: 154 YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA 213
+SW+KD L + G L I + D Y C+ + GE R+S A
Sbjct: 161 --PTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNM-VGE-RESEVA 215
Query: 214 RL-------FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
L FV P+N A ++ D E C+A G P P RW KD+ L
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDS-----------AEFKCEARGDPVPTVRWRKDDGELP 264
Query: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSS 326
S + L I + D GSY C N G A+ L V++P + PR +
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA 324
Query: 327 VGSQVSLSCSVTGTEDQELSWYRNG------EILNPGKNVRITGINHENLIMDHMVKSDG 380
+G V+ C TG + W R G P + R + +L + ++ +SD
Sbjct: 325 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 384
Query: 381 GAYQCFVRK--DKLSAQDYVQV--VLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKGTPL 435
G Y C + + Y++V V+ D P +I + V+ L C G+P+
Sbjct: 385 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV 444
Query: 436 PTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLY 495
PTI W D ++ RI Q+ E V L I +++ D G Y C A+ +G +
Sbjct: 445 PTILWR-KDGVLVSTQDSRIKQL---ENGV---LQIRYAKLGDTGRYTCIASTPSGEATW 497
Query: 496 QARINVR 502
A I V+
Sbjct: 498 SAYIEVQ 504
Score = 107 bits (268), Expect = 9e-23
Identities = 127/490 (25%), Positives = 188/490 (38%), Gaps = 43/490 (8%)
Query: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL---------IENIRPS--D 287
G+ L CKA G P P W K +E ++ LL I + R S D
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 288 SGSYVCEVSNRYGTAKVIGRLYVKQPLKATI--SPRKVKSSVGSQVSLSCS-VTGTEDQE 344
G YVC N G A L+ +P V +VG + C G +
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 345 LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLED 404
+SW ++G L+ K+ RIT I L++ + KSD G Y C + V +
Sbjct: 163 ISWKKDGSPLD-DKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
Query: 405 GTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN 464
P + S V+ + C +G P+PT+ W DD + K + I T
Sbjct: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDDHT---- 275
Query: 465 VVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS--IRPMKNITAIAGRDTY 522
L I D G Y C A N G A + V+ P ++P + A+ GR
Sbjct: 276 ----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL-GRTVT 330
Query: 523 IHCRVIGYPYYSIKWYK--NSNLL-----PFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
C G P +I W + + NLL P + + + G L +++VQ+ D G Y C
Sbjct: 331 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGYYIC 389
Query: 576 NVL-VQPQLSTSQSVHVTVKV----PPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 630
L V + T + VT + PP I+ + F+ V +G TI W
Sbjct: 390 QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 449
Query: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
+KDG + + I ++ L+I L G YTCIA + + + V+
Sbjct: 450 RKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFG 507
Query: 691 KFVVQPRDQD 700
V PR D
Sbjct: 508 VPVQPPRPTD 517
Score = 82.4 bits (202), Expect = 4e-15
Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 41/319 (12%)
Query: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
VL C A G P P + W KD + T D R NG IR K D+G Y+CIA+
Sbjct: 434 VLSCVATGSPVPTILWRKDG---VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 490
Query: 1364 NWGSDEIILNLQVQ---VPPDQPRLT-------------VSKTTSSSITLSWLPGDNGGS 1407
G ++VQ VP PR T V+ + +++TLSW P N G+
Sbjct: 491 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 550
Query: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
+ YI++ +S + W + + + ++ LK Y F + A N G P +IS
Sbjct: 551 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 610
Query: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGW--NDGGCPITSFTL 1511
+ ++ + + Q +++ + + L+ + W + I + +
Sbjct: 611 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 670
Query: 1512 EYRP----FGTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR-VCNSAGCAEKQANFAT 1565
YRP G + W + RT S ++ DL++ YE++ R N A+ + FA
Sbjct: 671 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 730
Query: 1566 LNYDGSTIPPLIKSVVQNE 1584
+ + PP +V +N+
Sbjct: 731 TLEEAPSAPPQGVTVSKND 749
Score = 53.5 bits (127), Expect = 2e-06
Identities = 30/74 (40%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C+A GDP P V+W KD P R I + + IR V A D G Y+C+A N G
Sbjct: 244 CEARGDPVPTVRWRKDDGELPK-----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 1367 SDEIILNLQVQVPP 1380
E L VQ PP
Sbjct: 299 KAEASATLTVQEPP 312
Score = 47.4 bits (111), Expect = 1e-04
Identities = 81/387 (20%), Positives = 144/387 (37%), Gaps = 68/387 (17%)
Query: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEP----LAKAPARILTFSGTVTT 1297
D + +I ++ S VA G+ +S +TV+ + K +++ TVT
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVT- 330
Query: 1298 PWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKA 1351
C+A G+P PA+ W ++ G+ +L+ R S+ G I V+
Sbjct: 331 -------FQCEATGNPQPAIFWRRE--GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 381
Query: 1352 EDSGYYSCIANNNWGSDEIILNLQV-QVPPDQPRLTVSK-TTSSSITLSWLPGDNGGSSI 1409
D GYY C N GS L+V V D+P + + + ++ + G+ +
Sbjct: 382 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD-------GTFV 434
Query: 1410 RGYILQYSEDNSEQWGSFPISPSERSYRLENL----------KCGTWYKFTLTAQNGVGP 1459
+ S + W + S + R++ L K G ++T A G
Sbjct: 435 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 494
Query: 1460 GRISEIIEAKTLG--KEPQFSKEQELFASI----NTTRVRLNLI--GW----NDGGCPIT 1507
S IE + G +P + L S T V N + W N G P T
Sbjct: 495 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-T 553
Query: 1508 SFTLE-YRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATL 1566
S+ +E + + W T +++ + L+ Y +R N+ G ++
Sbjct: 554 SYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD-------- 605
Query: 1567 NYDGSTIPPLIKSVVQNEEGLTTNEGL 1593
P I V+ ++ L T++G+
Sbjct: 606 -------PSQISDPVKTQDVLPTSQGV 625
Score = 35.0 bits (79), Expect = 0.74
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS---IFSN 1341
P RI+ + + L CKA G P+P ++W K G D RS + +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--GGERVETDKDDPRSHRMLLPS 85
Query: 1342 GS-FIIRTVKAE----DSGYYSCIANNNWG 1366
GS F +R V D G Y C+A N G
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
Score = 33.5 bits (75), Expect = 2.2
Identities = 38/171 (22%), Positives = 67/171 (39%), Gaps = 17/171 (9%)
Query: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
G P P + W KD G+P + R G +I + D+G Y C+ N G E
Sbjct: 157 GHPEPTISWKKD--GSP--LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
Query: 1371 -ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG---YILQYSEDNSEQWGS 1426
+ L V P V + ++ ++T+ RG +++ +D+ E S
Sbjct: 213 EVAELTVLERPS----FVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 1427 FPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQF 1477
+ + ++ + G +T A+N VG S + T+ + P F
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL---TVQEPPHF 314
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 229 bits (585), Expect = 2e-59
Identities = 261/981 (26%), Positives = 401/981 (40%), Gaps = 143/981 (14%)
Query: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--------TLDDDPILKGGSHR 454
ED P+I+ S+ +VS EP +L C +G P PTI W T DDP SHR
Sbjct: 64 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDP----RSHR 119
Query: 455 ISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRP 509
M+ G++ + + R D GVY C A N G V + A + V R P
Sbjct: 120 ---MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
Query: 510 MKNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568
+ A+ G + C+ G+P +I W K+ + L ++ G L ++ +K
Sbjct: 177 SDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKS- 233
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTV-KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
D G+Y C S+ +TV + P F++ ++ C +P T
Sbjct: 234 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-T 292
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
+ W+KD +P S D+ +L+I ++ G+YTC+A N E + L V+
Sbjct: 293 VRWRKDDGELPKSRYEIRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 348
Query: 688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP-QFQPIALNGRIQVL 746
PP FVV+PRDQ G+ V C A G P P I W+ + +QP + R V
Sbjct: 349 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408
Query: 747 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV------KIPAMITSYP-NTTLA 799
G L I +V D GYY+C+ N G+ ++K+ YL V + P +I P N T+A
Sbjct: 409 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKA-YLEVTDVIADRPPPVIRQGPVNQTVA 467
Query: 800 TQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED 859
G +SC A G + W K+ +++ + +R + E G LQI D
Sbjct: 468 VDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENG-----VLQIRYAKLGD 519
Query: 860 SGFFSCHAINSYGEDRGIIQLTVQE----------------PPDPPEIEIKDVKARTITL 903
+G ++C A GE + VQE P P + E+ DV T+TL
Sbjct: 520 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 579
Query: 904 RWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAK 963
W + + T Y IE + + S+ +T + + ++ I + P++ Y + A
Sbjct: 580 SWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLVRAA 637
Query: 964 NRIGKSEPSN-ELTITADEAAPDGPPQE------------VHLE---PISSQSIRVTWKA 1007
N G S+PS + + P + +HL +SS SI V W
Sbjct: 638 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 697
Query: 1008 PKKHLQNGIIRGYQIGYREYSTG-GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQA 1066
+ Q+ I+GY+I YR G + + V T + V + +L K Y + +
Sbjct: 698 DQ---QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARP 753
Query: 1067 CNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT--SPESISISWSTLSKEALNGILQGF 1124
G S+ TLE+ PS PP+ V + +I +SW ++ NG++Q +
Sbjct: 754 FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 813
Query: 1125 RVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRT 1184
+V W + K + + S+ + L YS++V A T AG GV+SE F +
Sbjct: 814 KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 871
Query: 1185 KEDVPGPP-----------------------AGVKAAAASASMVFVSWL--PPLKLNGI- 1218
D G P AG+ AA MVF WL K NG+
Sbjct: 872 --DAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLT 929
Query: 1219 -----IRKYTVFCSHPYPTV-----------------ISEFEASPDSFSYRIPNLSRNRQ 1256
IRK F P T ISE A P + PN N
Sbjct: 930 STYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQP-WLADTWPNTGNN-- 986
Query: 1257 YSVWVVAVTSAGRGNSSEIIT 1277
++ ++ +AG GNS +T
Sbjct: 987 HNDCSISCCTAGNGNSDSNLT 1007
Score = 150 bits (378), Expect = 2e-35
Identities = 197/861 (22%), Positives = 327/861 (37%), Gaps = 119/861 (13%)
Query: 487 NNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL-- 544
+NS G + R P + ++ G ++C+ G P +I+WYK +
Sbjct: 51 DNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVET 110
Query: 545 ----PFNHRQVAFENNGTLKLSDV----QKEVDEGEYTC---NVLVQPQLSTSQSVHVTV 593
P +HR + +G+L + + DEG Y C N L + +S + S+ V +
Sbjct: 111 DKDDPRSHRMLL--PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE-AVSHNASLEVAI 167
Query: 594 KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSS 653
F Q ++G+ + C G TI+W+KDG P +D+ D +
Sbjct: 168 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP--------LDDKDERIT 219
Query: 654 LRISNLSLMHN-----GNYTCIARNEAAAVEHQ-SQLIVRVPPKFVVQPRDQDGIYGKAV 707
+R L + + G Y C+ N E + ++L V P FV +P + +
Sbjct: 220 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 279
Query: 708 ILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCK 767
C A G PVPT+ W+ G +P+ R ++ + +L I+ V D G Y C
Sbjct: 280 EFKCEARGDPVPTVRWRKDDGE-LPK-------SRYEIRDDHTLKIRKVTAGDMGSYTCV 331
Query: 768 VSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDR- 826
N VG S LTV+ P P + G+ C A G + W +E
Sbjct: 332 AENMVG-KAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 390
Query: 827 ----IINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGE--DRGIIQL 880
P + S + G+ I+ +Q R D G++ C +N G + +++
Sbjct: 391 NLLFSYQPPQSSSRFSVSQTGDLTITNVQ-----RSDVGYYICQTLNVAGSIITKAYLEV 445
Query: 881 TVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSP 940
T PP + R + T+ DG + + C + KD
Sbjct: 446 TDVIADRPPPV------IRQGPVNQTVAVDGT-----FVLSCVATGSPVPTILWRKDGVL 494
Query: 941 QLNSATIIDIHPSSTYSIRMYAKNRIGK-----SEPSNELT-----------ITADEAAP 984
+ I + IR G+ S PS E T + P
Sbjct: 495 VSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRP 554
Query: 985 DGP------PQEVHLEPISSQSIRVTWKAPKKHLQNGII-RGYQIGYREYSTGGNFQFNI 1037
P P + + +S ++ ++W + +L +G Y I +++G ++Q
Sbjct: 555 TDPNLIPSAPSKPEVTDVSRNTVTLSW---QPNLNSGATPTSYIIEAFSHASGSSWQ--- 608
Query: 1038 ISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDV----PSYPPE 1093
+V + +E + L Y +V+A N G SQ +DV +
Sbjct: 609 -TVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHK 667
Query: 1094 NVQ------------AIATSPESISISWSTLSKEALNGILQGFRVIY---WANLMDGELG 1138
VQ S SI + W+ + + +QG++++Y AN + +
Sbjct: 668 QVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQGYKILYRPSGANHGESDWL 724
Query: 1139 EIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP-GPPAGVKA 1197
+ T + S+ + L K NY I+ F G SE F +T E+ P PP GV
Sbjct: 725 VFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTV 784
Query: 1198 AA--ASASMVFVSWLPPLK--LNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSR 1253
+ + + + VSW PP + NG++++Y V+C +FS IP L
Sbjct: 785 SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVP 844
Query: 1254 NRQYSVWVVAVTSAGRGNSSE 1274
+YSV V A T AG G SE
Sbjct: 845 GIRYSVEVAASTGAGSGVKSE 865
Score = 127 bits (319), Expect = 1e-28
Identities = 193/853 (22%), Positives = 335/853 (39%), Gaps = 105/853 (12%)
Query: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
P + P + S G +L+C G + WY+ GE + K+ +
Sbjct: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
Query: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQV-VLEDGTPKIISAFSEKVVSP 420
+ ++ + D G Y C R + +S ++V +L D S+ +V+
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVMVAV 183
Query: 421 AEPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
EP + C +G P PTI+W D P+ + IT G L I+ ++ D
Sbjct: 184 GEPAVMECQPPRGHPEPTISWKKDGSPL-----DDKDERITIRG---GKLMITYTRKSDA 235
Query: 480 GVYRCTANNSAGVVLYQ-ARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKW 537
G Y C N G + A + V P+ ++ N+ C G P +++W
Sbjct: 236 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 295
Query: 538 YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597
K+ LP + ++ ++ TLK+ V D G YTC V S +TV+ PP
Sbjct: 296 RKDDGELPKSRYEI--RDDHTLKIRKVTAG-DMGSYTC-VAENMVGKAEASATLTVQEPP 351
Query: 598 -FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG--------RPIPGSLGVTIDNI 648
F+ ++G+ V C P I W+++G +P S ++
Sbjct: 352 HFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQ- 409
Query: 649 DFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQDGI 702
T L I+N+ G Y C N A ++ ++ L V R PP P +Q
Sbjct: 410 --TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 467
Query: 703 YGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSG 762
+L+C A G PVPTI+W+ K + Q + RI+ L NG L I++ D+G
Sbjct: 468 VDGTFVLSCVATGSPVPTILWR--KDGVLVSTQ----DSRIKQLENGVLQIRYAKLGDTG 521
Query: 763 YYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTT----LATQGQKKEMSCTAHGEKPII 818
Y C S G + + S Y+ V+ + P T + + K E+ T +
Sbjct: 522 RYTCIASTPSG-EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNTVT 578
Query: 819 VRWEKE--------DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-FSCHAIN 869
+ W+ II S + V E V + + ++ ++ + F A N
Sbjct: 579 LSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAAN 638
Query: 870 SYG------------------EDRGIIQLTVQEPPDPPEIEIKD---VKARTITLRWTMG 908
+YG +G+ VQ + + + + + +I + WT+
Sbjct: 639 AYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD 698
Query: 909 FDGNSPITGYDIECK-NKSDSWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYA-KNR 965
+ I GY I + + ++ +S +V +P NS I D+ Y I+ N
Sbjct: 699 -QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNE 757
Query: 966 IGKSEPSNELTITADEAAPDGPPQEVHLEPI--SSQSIRVTWKAPKKHLQNGIIRGYQIG 1023
++ + T +E AP PPQ V + + +I V+W+ P + QNG+++ Y++
Sbjct: 758 FQGADSEIKFAKTLEE-APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV- 815
Query: 1024 YREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ-EIITT 1082
+ G +++ I+ G + + L +Y + V A AG+G S+ + I
Sbjct: 816 ---WCLGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 871
Query: 1083 TLEDVPSYPPENV 1095
P P + V
Sbjct: 872 DAHGNPVSPEDQV 884
Score = 122 bits (307), Expect = 3e-27
Identities = 129/487 (26%), Positives = 194/487 (39%), Gaps = 62/487 (12%)
Query: 46 CPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPPSSFSTLIH----- 96
C A G P T+ WY GE + D R + P+G+L F ++H
Sbjct: 89 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLPSGSL--------FFLRIVHGRKSR 139
Query: 97 --DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEA 153
+ Y C A N G+ S + ++ A+LR+ + D G AV +C P
Sbjct: 140 PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE 199
Query: 154 YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA 213
+SW+KD L + G L I + D Y C+ + GE R+S A
Sbjct: 200 --PTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNM-VGE-RESEVA 254
Query: 214 RL-------FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
L FV P+N A ++ D E C+A G P P RW KD+ L
Sbjct: 255 ELTVLERPSFVKRPSNLAVTVDDS-----------AEFKCEARGDPVPTVRWRKDDGELP 303
Query: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSS 326
S + L I + D GSY C N G A+ L V++P + PR +
Sbjct: 304 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA 363
Query: 327 VGSQVSLSCSVTGTEDQELSWYRNG------EILNPGKNVRITGINHENLIMDHMVKSDG 380
+G V+ C TG + W R G P + R + +L + ++ +SD
Sbjct: 364 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 423
Query: 381 GAYQCFVRK--DKLSAQDYVQV--VLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKGTPL 435
G Y C + + Y++V V+ D P +I + V+ L C G+P+
Sbjct: 424 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV 483
Query: 436 PTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLY 495
PTI W D ++ RI Q+ E V L I +++ D G Y C A+ +G +
Sbjct: 484 PTILWR-KDGVLVSTQDSRIKQL---ENGV---LQIRYAKLGDTGRYTCIASTPSGEATW 536
Query: 496 QARINVR 502
A I V+
Sbjct: 537 SAYIEVQ 543
Score = 107 bits (268), Expect = 9e-23
Identities = 127/490 (25%), Positives = 188/490 (38%), Gaps = 43/490 (8%)
Query: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL---------IENIRPS--D 287
G+ L CKA G P P W K +E ++ LL I + R S D
Sbjct: 82 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 141
Query: 288 SGSYVCEVSNRYGTAKVIGRLYVKQPLKATI--SPRKVKSSVGSQVSLSCS-VTGTEDQE 344
G YVC N G A L+ +P V +VG + C G +
Sbjct: 142 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 201
Query: 345 LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLED 404
+SW ++G L+ K+ RIT I L++ + KSD G Y C + V +
Sbjct: 202 ISWKKDGSPLD-DKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 259
Query: 405 GTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN 464
P + S V+ + C +G P+PT+ W DD + K + I T
Sbjct: 260 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDDHT---- 314
Query: 465 VVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS--IRPMKNITAIAGRDTY 522
L I D G Y C A N G A + V+ P ++P + A+ GR
Sbjct: 315 ----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL-GRTVT 369
Query: 523 IHCRVIGYPYYSIKWYK--NSNLL-----PFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
C G P +I W + + NLL P + + + G L +++VQ+ D G Y C
Sbjct: 370 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGYYIC 428
Query: 576 NVL-VQPQLSTSQSVHVTVKV----PPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 630
L V + T + VT + PP I+ + F+ V +G TI W
Sbjct: 429 QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 488
Query: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
+KDG + + I ++ L+I L G YTCIA + + + V+
Sbjct: 489 RKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFG 546
Query: 691 KFVVQPRDQD 700
V PR D
Sbjct: 547 VPVQPPRPTD 556
Score = 82.4 bits (202), Expect = 4e-15
Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 41/319 (12%)
Query: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
VL C A G P P + W KD + T D R NG IR K D+G Y+CIA+
Sbjct: 473 VLSCVATGSPVPTILWRKDG---VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 529
Query: 1364 NWGSDEIILNLQVQ---VPPDQPRLT-------------VSKTTSSSITLSWLPGDNGGS 1407
G ++VQ VP PR T V+ + +++TLSW P N G+
Sbjct: 530 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 589
Query: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
+ YI++ +S + W + + + ++ LK Y F + A N G P +IS
Sbjct: 590 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 649
Query: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGW--NDGGCPITSFTL 1511
+ ++ + + Q +++ + + L+ + W + I + +
Sbjct: 650 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 709
Query: 1512 EYRP----FGTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR-VCNSAGCAEKQANFAT 1565
YRP G + W + RT S ++ DL++ YE++ R N A+ + FA
Sbjct: 710 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 769
Query: 1566 LNYDGSTIPPLIKSVVQNE 1584
+ + PP +V +N+
Sbjct: 770 TLEEAPSAPPQGVTVSKND 788
Score = 53.5 bits (127), Expect = 2e-06
Identities = 30/74 (40%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C+A GDP P V+W KD P R I + + IR V A D G Y+C+A N G
Sbjct: 283 CEARGDPVPTVRWRKDDGELPK-----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 337
Query: 1367 SDEIILNLQVQVPP 1380
E L VQ PP
Sbjct: 338 KAEASATLTVQEPP 351
Score = 47.4 bits (111), Expect = 1e-04
Identities = 81/387 (20%), Positives = 144/387 (37%), Gaps = 68/387 (17%)
Query: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEP----LAKAPARILTFSGTVTT 1297
D + +I ++ S VA G+ +S +TV+ + K +++ TVT
Sbjct: 311 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVT- 369
Query: 1298 PWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKA 1351
C+A G+P PA+ W ++ G+ +L+ R S+ G I V+
Sbjct: 370 -------FQCEATGNPQPAIFWRRE--GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 420
Query: 1352 EDSGYYSCIANNNWGSDEIILNLQV-QVPPDQPRLTVSK-TTSSSITLSWLPGDNGGSSI 1409
D GYY C N GS L+V V D+P + + + ++ + G+ +
Sbjct: 421 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD-------GTFV 473
Query: 1410 RGYILQYSEDNSEQWGSFPISPSERSYRLENL----------KCGTWYKFTLTAQNGVGP 1459
+ S + W + S + R++ L K G ++T A G
Sbjct: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 533
Query: 1460 GRISEIIEAKTLG--KEPQFSKEQELFASI----NTTRVRLNLI--GW----NDGGCPIT 1507
S IE + G +P + L S T V N + W N G P T
Sbjct: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-T 592
Query: 1508 SFTLE-YRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATL 1566
S+ +E + + W T +++ + L+ Y +R N+ G ++
Sbjct: 593 SYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD-------- 644
Query: 1567 NYDGSTIPPLIKSVVQNEEGLTTNEGL 1593
P I V+ ++ L T++G+
Sbjct: 645 -------PSQISDPVKTQDVLPTSQGV 664
Score = 35.0 bits (79), Expect = 0.74
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS---IFSN 1341
P RI+ + + L CKA G P+P ++W K G D RS + +
Sbjct: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--GGERVETDKDDPRSHRMLLPS 124
Query: 1342 GS-FIIRTVKAE----DSGYYSCIANNNWG 1366
GS F +R V D G Y C+A N G
Sbjct: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLG 154
Score = 33.5 bits (75), Expect = 2.2
Identities = 38/171 (22%), Positives = 67/171 (39%), Gaps = 17/171 (9%)
Query: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
G P P + W KD G+P + R G +I + D+G Y C+ N G E
Sbjct: 196 GHPEPTISWKKD--GSP--LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251
Query: 1371 -ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG---YILQYSEDNSEQWGS 1426
+ L V P V + ++ ++T+ RG +++ +D+ E S
Sbjct: 252 EVAELTVLERPS----FVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRKDDGELPKS 305
Query: 1427 FPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQF 1477
+ + ++ + G +T A+N VG S + T+ + P F
Sbjct: 306 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL---TVQEPPHF 353
>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
sapiens]
Length = 1183
Score = 229 bits (583), Expect = 3e-59
Identities = 279/1133 (24%), Positives = 450/1133 (39%), Gaps = 127/1133 (11%)
Query: 310 VKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRIT-----G 364
V+ P SP+ + + C G SW RNG + K+ +T G
Sbjct: 37 VQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTG 96
Query: 365 INHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKV-VSPAEP 423
N++ + ++ G YQC R ++ +A VV +P E + + +
Sbjct: 97 TLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQS 156
Query: 424 VSLMCNVK-GTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVY 482
+ L C G P P I W +D+ S R+SQ + + + + N+ R+ Y
Sbjct: 157 LVLPCRPPIGLPPPIIFW-MDNSFQRLPQSERVSQGLNGD---LYFSNVLPEDTRED--Y 210
Query: 483 RCTAN-----------------------------NSAGVVLYQARIN-VRGPASIRPMKN 512
C A N + Y A+ + R P + P N
Sbjct: 211 ICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGN 270
Query: 513 IT---AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVD 569
+ + G + C G P I W K +LP N R V TL++ V E D
Sbjct: 271 ASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKN-RTVYKNFEKTLQIIHVS-EAD 328
Query: 570 EGEYTCNVLVQPQLSTSQSVHVTVKVPPF-IQPFEFPRFSIGQRVFIPCVVVSGDLPITI 628
G Y C + + ++ V VK P+ I + S G+ + C P I
Sbjct: 329 SGNYQC-IAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKP-RI 386
Query: 629 TWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRV 688
+W +G PI + ID ++ SN+ + Y C A NE + + + V
Sbjct: 387 SWLTNGVPIEIAPDDPSRKID-GDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLA 445
Query: 689 PPKFVVQPRDQ--DGIYGKAVILNCSAEGYPVPTIVW-KFSKGAGVPQFQPIALNGRIQV 745
P ++ P + I + +L+C+ G P+PTI W K +KG+ AL+ I V
Sbjct: 446 EPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGS--------ALHEDIYV 497
Query: 746 L-SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQK 804
L NG+L I ++ +G Y C N +G ++L +K P I P + +G
Sbjct: 498 LHENGTLEIPVAQKDSTGTYTCVARNKLGM-AKNEVHLEIKDPTWIVKQPEYAVVQRGSM 556
Query: 805 KEMSCTAHGEKPI--IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 862
C + + V W K++R + P R+ V L + +DSG
Sbjct: 557 VSFECKVKHDHTLSLTVLWLKDNREL-PSDERFTVDKDH--------LVVADVSDDDSGT 607
Query: 863 FSCHAINSYGEDRGIIQLTVQEPPDPP-EIEIKDVKARTITLRWTMGFDGNSPITGYDIE 921
++C A + L+V + P+PP ++E+ D +++ L WT G D NSPIT + IE
Sbjct: 608 YTCVANTTLDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIE 667
Query: 922 CKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADE 981
++ +VS +A + + P YS R+ A N IGKS PS +
Sbjct: 668 YEDAMHKPGLWHHQTEVSGTQTTAQL-KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTK 726
Query: 982 AA-PDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISV 1040
A+ PD P V ++ +TWK NG Y++ +R+ G + +++
Sbjct: 727 ASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQ-KDGDDEWTSVVVA 785
Query: 1041 DTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT 1100
+ S Y + F Y + VQA N G P ++ + ED+P P NV+
Sbjct: 786 NVSK----YIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVV 841
Query: 1101 SPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGE---IKNITTTQPSLE---LDG 1154
+ + W + +++ G LQG+R+ YW + K I T Q S L G
Sbjct: 842 NSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPG 901
Query: 1155 LEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLK 1214
LE +++Y++ V G+G S T E VP P+ +K + + + W PP
Sbjct: 902 LEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSH 961
Query: 1215 LNGIIRKYTVFCSHPYPTVISEFEASP--------DSFSYRIPNLSRNRQYSVWVVAVTS 1266
NGI+ +YT+ Y + S E P + + + NL+ + +Y + A TS
Sbjct: 962 PNGILTEYTL----KYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTS 1017
Query: 1267 AGRGN--SSEIITV--EPLAKAPARILT---FSGTVTTPWMKDIVL-------------- 1305
AG G+ + E +T E +A I T F G + + ++L
Sbjct: 1018 AGSGSQITEEAVTTVDEAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKY 1077
Query: 1306 PCKAVGD--PSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFI--IRTVKAEDS 1354
P K D P ++ MK+ +GT + GS RTVK EDS
Sbjct: 1078 PVKEKEDAHADPEIQPMKEDDGTFGEYSDAEDHKPLKKGSRTPSDRTVKKEDS 1130
Score = 147 bits (370), Expect = 1e-34
Identities = 238/1029 (23%), Positives = 376/1029 (36%), Gaps = 132/1029 (12%)
Query: 240 QRVELPCKALGHPEPDYRWLKDNMPLELSGR---FQKTVTGLLIENIRPSD-----SGSY 291
+ + + C+A G P P + W ++ ++ K TG LI NI G Y
Sbjct: 56 ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVY 115
Query: 292 VCEVSNRYGTAKVIGRLYV---KQPL--KATISPRKVKSSVGSQVSLSC-SVTGTEDQEL 345
C N G A V + V + PL K + P ++S G + L C G +
Sbjct: 116 QCTARNERGAA-VSNNIVVRPSRSPLWTKEKLEPITLQS--GQSLVLPCRPPIGLPPPII 172
Query: 346 SWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDY-----VQV 400
W N P G+N + + + + Y C+ R + V+V
Sbjct: 173 FWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKV 232
Query: 401 VLEDGTPKIISA--------------------------FSEKVVSPAEPVSLMCNVKGTP 434
+ D I+A S K +SL C +G P
Sbjct: 233 ISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLP 292
Query: 435 LPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVL 494
P I W +D + K T N L I D G Y+C A N+ G +
Sbjct: 293 TPIIYWAKEDGMLPKNR--------TVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIH 344
Query: 495 YQARINVR-GPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAF 553
+ + V+ P I +N+ G D + CR G P I W N + +
Sbjct: 345 HTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSR 404
Query: 554 ENNG-TLKLSDVQKEVDEGEYTCNVLVQ-PQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQ 611
+ +G T+ S+VQ E Y CN + L + V+V + P + P I
Sbjct: 405 KIDGDTIIFSNVQ-ERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIAN 463
Query: 612 R-VFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCI 670
R + C LP TI W K + +L I + +L I G YTC+
Sbjct: 464 RPALLDCAFFGSPLP-TIEWFKGAK--GSALHEDIYVLHENGTLEIPVAQKDSTGTYTCV 520
Query: 671 ARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPV--PTIVWKFSKG 728
ARN+ +++ L ++ P V QP G V C + T++W
Sbjct: 521 ARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLW----- 575
Query: 729 AGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPA 788
+ + + + R V L++ V ++DSG Y C V+N VS S L+V
Sbjct: 576 --LKDNRELPSDERFTV-DKDHLVVADVSDDDSGTYTC-VANTTLDSVSASAVLSV---- 627
Query: 789 MITSYPNTTLATQGQKKEMSCTAHGEKPIIVRW---------------EKEDRIINPEMA 833
PN ++ T +K + + W E ED + P +
Sbjct: 628 --VDVPNPPF-------DLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLW 678
Query: 834 RYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGE----DRGIIQLTVQEPPD-- 887
+ T+ G + + L++ P V F A+NS G+ + LT PD
Sbjct: 679 HH--QTEVSGTQTTAQLKLSPYVNYS---FRVMAVNSIGKSLPSEASEQYLTKASEPDKN 733
Query: 888 PPEIEIKDVKARTITLRW--TMGFDGNSPITGYDIECKNK--SDSWDSAQRTKDVSPQLN 943
P +E + + + W GF+ N P Y + + K D W S +VS +
Sbjct: 734 PTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVV-VANVSKYIV 792
Query: 944 SATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRV 1003
S T + Y I++ A N +G + + + E P P V + ++S V
Sbjct: 793 SGTPTFV----PYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEV 848
Query: 1004 TWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIIS---VDTSGDSEVYTLDNLNKFTQY 1060
W G ++GY+I Y + + I + G L L F+ Y
Sbjct: 849 HWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHY 908
Query: 1061 GLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGI 1120
L V+ N G GP+S + + T E VPS P +++ + + +S+++ W S NGI
Sbjct: 909 TLNVRVVNGKGEGPASPDRVFNTPEGVPS-APSSLKIVNPTLDSLTLEWDPPSHP--NGI 965
Query: 1121 LQGFRVIYWANLMDGELGEIKN--ITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVR-S 1177
L + + Y ELG + + I + L L T Y A T AG G + +
Sbjct: 966 LTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQIT 1025
Query: 1178 EQIFTRTKE 1186
E+ T E
Sbjct: 1026 EEAVTTVDE 1034
Score = 145 bits (366), Expect = 4e-34
Identities = 197/885 (22%), Positives = 340/885 (38%), Gaps = 103/885 (11%)
Query: 398 VQVVLEDGTPKIISAFSEK--VVSPAEPVSLMCNVKGTPLPTITWT-------LDDDPI- 447
++V L+ P I+ S K ++ P E + + C KG P P+ +WT +D DP+
Sbjct: 30 LEVPLDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLV 89
Query: 448 -LKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS 506
+K G+ + I SEG +Y GVY+CTA N G + I VR S
Sbjct: 90 TMKPGTGTLIINIMSEGKAETY----------EGVYQCTARNERGAAV-SNNIVVRPSRS 138
Query: 507 ----IRPMKNITAIAGRDTYIHCR-VIGYPYYSIKWYKNS-NLLPFNHRQVAFENNGTLK 560
++ IT +G+ + CR IG P I W NS LP + R V+ NG L
Sbjct: 139 PLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDNSFQRLPQSER-VSQGLNGDLY 197
Query: 561 LSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKV------------------------- 595
S+V E +Y C + Q ++VKV
Sbjct: 198 FSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSS 257
Query: 596 ----PPFIQP---FEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNI 648
P F+ P G + + C+ PI I W K+ +P + V
Sbjct: 258 RERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPI-IYWAKEDGMLPKNRTV---YK 313
Query: 649 DFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVI 708
+F +L+I ++S +GNY CIA+N A+ H + V+ P ++ P++ G+
Sbjct: 314 NFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGT 373
Query: 709 LNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKV 768
L C A G P P I W + GVP IA + + + +++ +V E S Y C
Sbjct: 374 LICRANGNPKPRISWLTN---GVP--IEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNA 428
Query: 769 SNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKE-MSCTAHGEKPIIVRWEKEDRI 827
SN+ G ++ + + P I + NT + + C G + W K +
Sbjct: 429 SNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKG 488
Query: 828 INPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP- 886
Y++ TL+I ++ +G ++C A N G + + L +++P
Sbjct: 489 SALHEDIYVLHEN-------GTLEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTW 541
Query: 887 --DPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNS 944
PE + + ++ + D +T ++ + S + KD
Sbjct: 542 IVKQPEYAVVQ-RGSMVSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKD------H 594
Query: 945 ATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVT 1004
+ D+ + + A + S L++ PP ++ L +S++++
Sbjct: 595 LVVADVSDDDSGTYTCVANTTLDSVSASAVLSV----VDVPNPPFDLELTDQLDKSVQLS 650
Query: 1005 WKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVV 1064
W + N I + I Y + + + SG L L+ + Y V
Sbjct: 651 WTPGDDN--NSPITKFIIEYEDAMHKPGLWHH--QTEVSGTQTTAQL-KLSPYVNYSFRV 705
Query: 1065 QACNRAGTG-PSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQG 1123
A N G PS T P P V+ + + P+++ I+W L+ NG
Sbjct: 706 MAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQ 765
Query: 1124 FRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTR 1183
++V + DG+ + + G + Y I+V A G +
Sbjct: 766 YKVSW--RQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGH 823
Query: 1184 TKEDVP-GPPAGVKAAAASASMVFVSWLP-PLK-LNGIIRKYTVF 1225
+ ED+P P V+ ++++ V W P PLK + G ++ Y ++
Sbjct: 824 SGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIY 868
Score = 112 bits (281), Expect = 3e-24
Identities = 143/597 (23%), Positives = 230/597 (38%), Gaps = 61/597 (10%)
Query: 43 LVPCPAAGIPPVTLRWYL-ATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYY 101
++ C A G PP + W T +I P + GTL I T ++ Y
Sbjct: 59 VIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAET--YEGVYQ 116
Query: 102 CTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTMR-GNVAVFKCIIPSSVEAYITVVSW 160
CTA N G S ++ ++ +T + T++ G V C P + ++ W
Sbjct: 117 CTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPP--PIIFW 174
Query: 161 EKDTVS-LVSGSRFLITSTGALYIKDVQNEDGLYNYRCITR--HRYTGETRQSNSARLFV 217
++ L R G LY +V ED +Y C R H T + +Q S ++
Sbjct: 175 MDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVIS 234
Query: 218 SDPANSA--------------------PSILD---GFDHRKAMAGQRVELPCKALGHPEP 254
D N P+ L +++ + G + L C A G P P
Sbjct: 235 VDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTP 294
Query: 255 DYRWLKDNMPLELSG----RFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYV 310
W K++ L + F+KT L I ++ +DSG+Y C N G + V
Sbjct: 295 IIYWAKEDGMLPKNRTVYKNFEKT---LQIIHVSEADSGNYQCIAKNALGAIHHTISVRV 351
Query: 311 KQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENL 370
K +P+ + S G +L C G +SW NG + + I+ + +
Sbjct: 352 KAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRISWLTNGVPIEIAPDDPSRKIDGDTI 411
Query: 371 IMDHMVKSDGGAYQCFVRKD--KLSAQDYVQVVLEDGTPKIIS-AFSEKVVSPAEPVSLM 427
I ++ + YQC + L A +V V+ E P+I++ A + V P L
Sbjct: 412 IFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAE--PPRILTPANTLYQVIANRPALLD 469
Query: 428 CNVKGTPLPTITWTLDDDPILKGGS-HRISQMITSEGNVVSYLNISSSQVRDGGVYRCTA 486
C G+PLPTI W KG + H ++ G L I +Q G Y C A
Sbjct: 470 CAFFGSPLPTIEWFKG----AKGSALHEDIYVLHENGT----LEIPVAQKDSTGTYTCVA 521
Query: 487 NNSAGVVLYQARINVRGPASIRPMKNITAI-AGRDTYIHCRVIGYPYYS--IKWYKNSNL 543
N G+ + + ++ P I + G C+V S + W K++
Sbjct: 522 RNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRE 581
Query: 544 LPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC--NVLVQPQLSTSQSVHVTVKVPPF 598
LP + R +++ L ++DV + D G YTC N + +++ V V PPF
Sbjct: 582 LPSDERFTVDKDH--LVVADVSDD-DSGTYTCVANTTLDSVSASAVLSVVDVPNPPF 635
Score = 64.3 bits (155), Expect = 1e-09
Identities = 72/281 (25%), Positives = 118/281 (41%), Gaps = 25/281 (8%)
Query: 1307 CKAVGDP--SPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNN 1364
CK D S V W+KD+ PS R ++ V +DSG Y+C+AN
Sbjct: 561 CKVKHDHTLSLTVLWLKDNRELPS-----DERFTVDKDHLVVADVSDDDSGTYTCVANTT 615
Query: 1365 WGSDEIILNLQVQVPPDQP-RLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQ 1423
S L V P+ P L ++ S+ LSW PGD+ S I +I++Y ED +
Sbjct: 616 LDSVSASAVLSVVDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEY-EDAMHK 674
Query: 1424 WGSF----PISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSK 1479
G + +S ++ + +L+ L Y F + A N +G SE E + L K + K
Sbjct: 675 PGLWHHQTEVSGTQTTAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASE-QYLTKASEPDK 732
Query: 1480 EQELFASINTTRVRLNLIGWN-----DGGCPITSFTLEYR-PFGTTVWTTAQRTSLSKSY 1533
+ + L +I W + P + + +R G WT+ ++SK Y
Sbjct: 733 NPTAVEGLGSEPDNL-VITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSK-Y 790
Query: 1534 ILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIP 1574
I+ Y ++++ N G A + A + + G +P
Sbjct: 791 IVSGTPTFVPYLIKVQALNDMGFAPEPA--VVMGHSGEDLP 829
Score = 55.8 bits (133), Expect = 4e-07
Identities = 83/370 (22%), Positives = 142/370 (38%), Gaps = 59/370 (15%)
Query: 559 LKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQR--VFIP 616
LK+ +K + G +L Q+ ++ V + + PP I + I R + I
Sbjct: 3 LKIMPKKKRLSAGRVPL-ILFLCQMISALEVPLDLVQPPTITQQSPKDYIIDPRENIVIQ 61
Query: 617 CVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSL----MHNGNYTCIAR 672
C G P + +W ++G + T +L I+ +S + G Y C AR
Sbjct: 62 CEA-KGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTAR 120
Query: 673 NEAAAVEHQSQLIVRVPPKFVVQPRDQDGI---YGKAVILNCSAE-GYPVPTIVWKFSKG 728
NE A + ++VR + + I G++++L C G P P I W +
Sbjct: 121 NERGAAV-SNNIVVRPSRSPLWTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDN-- 177
Query: 729 AGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY-YLC--------------------- 766
FQ + + R+ NG L +V+ ED+ Y+C
Sbjct: 178 ----SFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVI 233
Query: 767 ---KVSNDVGADVSKSMYLTVKI-----PAMITSYPNTTLATQ--GQKKEMSCTAHGEKP 816
++++ + A++S + + K P +T N + + G + C A G
Sbjct: 234 SVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPT 293
Query: 817 IIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRG 876
I+ W KED + L + V + TLQI+ DSG + C A N+ G
Sbjct: 294 PIIYWAKEDGM--------LPKNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHH 345
Query: 877 IIQLTVQEPP 886
I + V+ P
Sbjct: 346 TISVRVKAAP 355
Score = 50.1 bits (118), Expect = 2e-05
Identities = 98/441 (22%), Positives = 168/441 (38%), Gaps = 69/441 (15%)
Query: 1086 DVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYW-ANLMDGELGEIKNIT 1144
DVP+ PP +++ +S+ +SW+ N + F + Y A G ++
Sbjct: 629 DVPN-PPFDLELTDQLDKSVQLSWTPGDDN--NSPITKFIIEYEDAMHKPGLWHHQTEVS 685
Query: 1145 TTQPSLELDGLEKYTNYSIQVLAFTRAGDGV---RSEQIFTRTKEDVPGPPAGVKAAAAS 1201
TQ + +L L Y NYS +V+A G + SEQ T+ E P A V+ +
Sbjct: 686 GTQTTAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTA-VEGLGSE 743
Query: 1202 ASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNR------ 1255
+ ++W P LNG Y + + + S + N+S+
Sbjct: 744 PDNLVITWKP---LNGFESNGPGL---QYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPT 797
Query: 1256 --QYSVWVVAVTSAG--------RGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVL 1305
Y + V A+ G G+S E + + +A R+ + T+ +
Sbjct: 798 FVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPM--VAPGNVRVNVVNSTLAEVHWDPV-- 853
Query: 1306 PCKAVGDPSPAVK---WMKDSNGTPS-------LVTIDGRRSI--------FSNGSFIIR 1347
P K++ + W S+ + ++T G ++ FS+ + +R
Sbjct: 854 PLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVR 913
Query: 1348 TVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGS 1407
V + G S + + N VP L + T S+TL W P +
Sbjct: 914 VVNGKGEGP---------ASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNG 964
Query: 1408 SIRGYILQYSEDNS-EQWG---SFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPG-RI 1462
+ Y L+Y NS + G I ++ + L+NL T YKF AQ G G +I
Sbjct: 965 ILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQI 1024
Query: 1463 SEIIEAKTLGKEPQFSKEQEL 1483
+E EA T E S++ ++
Sbjct: 1025 TE--EAVTTVDEAMASRQVDI 1043
Score = 47.0 bits (110), Expect = 2e-04
Identities = 36/148 (24%), Positives = 61/148 (41%), Gaps = 13/148 (8%)
Query: 1253 RNRQYSVWVVAVTSAGRGNSSEII---------TVEPLAKAPARILTFSGTVTTPWMKDI 1303
+N + ++ ++ V+ A GN I T+ KA +T + +D
Sbjct: 313 KNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDG 372
Query: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
L C+A G+P P + W+ +NG P + D + I V+ S Y C A+N
Sbjct: 373 TLICRANGNPKPRISWL--TNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASN 430
Query: 1364 NWGSDEIILNLQVQVPPDQPRLTVSKTT 1391
+G ++ N V V + PR+ T
Sbjct: 431 EYG--YLLANAFVNVLAEPPRILTPANT 456
Score = 44.7 bits (104), Expect = 0.001
Identities = 63/298 (21%), Positives = 114/298 (38%), Gaps = 59/298 (19%)
Query: 1285 PARILTFSGTVTTPWM-KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGS 1343
P RILT + T+ + +L C G P P ++W K + G+ I + NG+
Sbjct: 447 PPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDI---YVLHENGT 503
Query: 1344 FIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPP---DQPRLTVSKTTSS------- 1393
I + + +G Y+C+A N G + ++L+++ P QP V + S
Sbjct: 504 LEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKV 563
Query: 1394 ------SITLSW------LPGDNGGSSIRGYIL--QYSEDNSEQWGSFPISPSERSYRLE 1439
S+T+ W LP D + + +++ S+D+S
Sbjct: 564 KHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDS------------------ 605
Query: 1440 NLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIGW 1499
GT+ T + V + +++ P F + EL ++ + V+L+
Sbjct: 606 ----GTYTCVANTTLDSVSASAVLSVVDV----PNPPF--DLELTDQLDKS-VQLSWTPG 654
Query: 1500 NDGGCPITSFTLEYRP--FGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAG 1555
+D PIT F +EY +W S +++ L Y ++ NS G
Sbjct: 655 DDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIG 712
Score = 39.3 bits (90), Expect = 0.039
Identities = 33/140 (23%), Positives = 59/140 (42%), Gaps = 16/140 (11%)
Query: 1251 LSRNRQYSVWVVAV-----TSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWM---KD 1302
+ + + SV V++V T A + +E + + P LT G +
Sbjct: 222 IQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNV 281
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAE--DSGYYSCI 1360
+ L C A G P+P + W K+ P R+++ N ++ + DSG Y CI
Sbjct: 282 LSLECIAEGLPTPIIYWAKEDGMLPK------NRTVYKNFEKTLQIIHVSEADSGNYQCI 335
Query: 1361 ANNNWGSDEIILNLQVQVPP 1380
A N G+ ++++V+ P
Sbjct: 336 AKNALGAIHHTISVRVKAAP 355
Score = 32.3 bits (72), Expect = 4.8
Identities = 28/95 (29%), Positives = 41/95 (43%), Gaps = 11/95 (11%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMK-----DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAED-S 1354
++IV+ C+A G P P+ W + D + P + G ++ N I+ KAE
Sbjct: 56 ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIIN---IMSEGKAETYE 112
Query: 1355 GYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSK 1389
G Y C A N G+ + N V P P T K
Sbjct: 113 GVYQCTARNERGA--AVSNNIVVRPSRSPLWTKEK 145
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 228 bits (582), Expect = 3e-59
Identities = 228/832 (27%), Positives = 352/832 (42%), Gaps = 87/832 (10%)
Query: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPI-LKGGSHRISQMITS 461
ED P+I+ S+ +VS EP +L C +G P PTI W D + + R +M+
Sbjct: 43 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 102
Query: 462 EGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRPMKNITAI 516
G++ + + + D G Y C A N G V A + V R P + A
Sbjct: 103 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA- 161
Query: 517 AGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
AG + C+ G+P +I W K+ + +++ G L +S+ +K D G YTC
Sbjct: 162 AGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKS-DAGMYTC 219
Query: 576 NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVV-----VSGDLPITITW 630
S +TV P F R I Q V V V GD T+ W
Sbjct: 220 VGTNMVGERDSDPAELTVFERP-----TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW 274
Query: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
+KD +P D D+T LRI G Y CIA N +E + L VR PP
Sbjct: 275 KKDDADLPRGRYDIKD--DYT--LRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 330
Query: 691 KFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQF--QPIALNGRIQVLSN 748
+FVV+PRDQ G+ V C +G P P + W+ +G+ F QP N R V
Sbjct: 331 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQ-KEGSQNLLFPNQPQQPNSRCSVSPT 389
Query: 749 GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSM-----YLTVKIPAMITSYP-NTTLATQG 802
G L I ++ D+GYY+C+ G+ ++K+ LT + P +I P N TLA G
Sbjct: 390 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 449
Query: 803 QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 862
+ C A G+ ++ W KE R + + TLQI D+G
Sbjct: 450 TAL-LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQ-------GTLQIKNLRISDTGT 501
Query: 863 FSCHAINSYGEDRGIIQLTVQE--------------PPDPPEIEIKDVKARTITLRWTMG 908
++C A +S GE L V E P P + ++ DV ++TL W G
Sbjct: 502 YTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPG 561
Query: 909 FDGNSPITGYDIEC--KNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRI 966
G P + Y IE ++ S+SW + + T+ + P++ Y + A N
Sbjct: 562 TPGTLPASAYIIEAFSQSVSNSWQTVAN----HVKTTLYTVRGLRPNTIYLFMVRAINPQ 617
Query: 967 GKSEPS--NELTITADEAAPDGPPQEVHLEP--------------ISSQSIRVTWKAPKK 1010
G S+PS ++ T D + P ++ ++ +++VTW +
Sbjct: 618 GLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR- 676
Query: 1011 HLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSE-VYTLDNLNKFTQYGLVVQACNR 1069
Q I+GY++ YR+ ++G + ++D +E L NL K Y + V+
Sbjct: 677 --QPQFIQGYRVMYRQ-TSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFN 733
Query: 1070 AGTGPSSQEIITTTLEDVPSYPPENVQAIAT---SPESISISWSTLSKEALNGILQGFRV 1126
G S+ T E+ PS PP++V + + SIS+SW + NGI+Q +++
Sbjct: 734 EFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI 793
Query: 1127 IYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSE 1178
W + K + S+ + GL Y ++V A T AG GV+SE
Sbjct: 794 --WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSE 843
Score = 157 bits (397), Expect = 1e-37
Identities = 206/851 (24%), Positives = 332/851 (39%), Gaps = 134/851 (15%)
Query: 504 PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL------PFNHRQVAFENNG 557
P + ++ G T ++C+ G P +I+WYK+ + P +HR + +G
Sbjct: 47 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL--PSG 104
Query: 558 TLKLSDV----QKEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIG 610
+L + + + DEG Y C N L + +S + S+ V + F Q + G
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEA-VSRNASLEVALLRDDFRQNPTDVVVAAG 163
Query: 611 QRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLR-----ISNLSLMHNG 665
+ + C G TI W+KD V ID+ + S+R ISN G
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDK--------VRIDDKEERISIRGGKLMISNTRKSDAG 215
Query: 666 NYTCIARNEAAAVEHQ-SQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWK 724
YTC+ N + ++L V P F+ +P +Q + +AV C +G P PT+ WK
Sbjct: 216 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 275
Query: 725 FSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
A +P+ GR + + +L IK + D G Y+C N VG + S LTV
Sbjct: 276 -KDDADLPR-------GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK-MEASATLTV 326
Query: 785 KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKE--DRII---NPEMARYLVST 839
+ P P + QG+ C G V W+KE ++ P+ S
Sbjct: 327 RAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSV 386
Query: 840 KEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQE--PPDPPEIEIKDVK 897
G+ I+ +Q R D+G++ C A+ G QL V + PP I ++
Sbjct: 387 SPTGDLTITNIQ-----RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA 441
Query: 898 ARTITLRWTMGFDGNSPITGYDIECKNKSD-----SWDSAQRT------KDVSPQLNSAT 946
+T+ + DG + + +CK D SW T + + +
Sbjct: 442 NQTLAV------DGTALL-----KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQ 490
Query: 947 IIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD---------GPPQEVHLEPIS 997
I ++ S T + A + G++ S L +T A GPP + + ++
Sbjct: 491 IKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVT 550
Query: 998 SQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKF 1057
S+ ++W+ Y I S ++Q V T+ +YT+ L
Sbjct: 551 KNSVTLSWQPGTPGTLPA--SAYIIEAFSQSVSNSWQTVANHVKTT----LYTVRGLRPN 604
Query: 1058 TQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQ-----------------AIAT 1100
T Y +V+A N G S +D+ S P + V +
Sbjct: 605 TIYLFMVRAINPQGLSDPSPMSDPVRTQDI-SPPAQGVDHRQVQKELGDVLVRLHNPVVL 663
Query: 1101 SPESISISWSTLSKEALNGILQGFRVIY-----------WANLMDGELGEIKNITTTQPS 1149
+P ++ ++W+ + +QG+RV+Y W NL D ++ T+ S
Sbjct: 664 TPTTVQVTWTV---DRQPQFIQGYRVMYRQTSGLQATSSWQNL-DAKV-------PTERS 712
Query: 1150 LELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG-PPAGVKAAAA---SASMV 1205
L L+K Y I+V + G+ SE RT E+ P PP V +++ +
Sbjct: 713 AVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI 772
Query: 1206 FVSWLPPLK--LNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVA 1263
VSW PP NGII++Y ++C S I L QY V V A
Sbjct: 773 SVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAA 832
Query: 1264 VTSAGRGNSSE 1274
TSAG G SE
Sbjct: 833 STSAGVGVKSE 843
Score = 145 bits (365), Expect = 5e-34
Identities = 206/831 (24%), Positives = 327/831 (39%), Gaps = 99/831 (11%)
Query: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
P + P V S G +L+C G + WY++GE + K+ +
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPA 421
+ ++ K D G+Y C R + +S ++V L ++ VV+
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALL--RDDFRQNPTDVVVAAG 163
Query: 422 EPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGG 480
EP L C +G P PTI W D K + I+ G L IS+++ D G
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKD-----KVRIDDKEERISIRG---GKLMISNTRKSDAG 215
Query: 481 VYRCTANNSAGV-VLYQARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWY 538
+Y C N G A + V P +R N + C+V G P +++W
Sbjct: 216 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 275
Query: 539 KNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQ-SVHVTVKVPP 597
K+ LP + +++ TL++ DEG Y C + + ++ + S +TV+ PP
Sbjct: 276 KDDADLPRGRYDI--KDDYTLRIKKTM-STDEGTYMC--IAENRVGKMEASATLTVRAPP 330
Query: 598 FIQPFEFPRFSI---GQRVFIPCVVVSGDLPITITWQKDGR-----PIPGSLGVTIDNID 649
Q PR I G+ V PC P + WQK+G P + ++
Sbjct: 331 --QFVVRPRDQIVAQGRTVTFPCETKGNPQP-AVFWQKEGSQNLLFPNQPQQPNSRCSVS 387
Query: 650 FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQDGIY 703
T L I+N+ G Y C A A ++ ++QL V R PP + P +Q
Sbjct: 388 PTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV 447
Query: 704 GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY 763
+L C A G P+P I W +G P P R + G+L IK++ D+G
Sbjct: 448 DGTALLKCKATGDPLPVISW-LKEGFTFPGRDP-----RATIQEQGTLQIKNLRISDTGT 501
Query: 764 YLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK 823
Y C ++ G + S S L V S G + T + + + W+
Sbjct: 502 YTCVATSSSG-ETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQP 560
Query: 824 EDRIINPEMARYLV---------STKEVGEEVISTLQILPTVREDSGF-FSCHAINSYG- 872
P A Y++ S + V V +TL + +R ++ + F AIN G
Sbjct: 561 GTPGTLPASA-YIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGL 619
Query: 873 EDRGIIQLTVQ-EPPDPP---------EIEIKDVKAR----------TITLRWTMGFDGN 912
D + V+ + PP + E+ DV R T+ + WT+
Sbjct: 620 SDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQ 679
Query: 913 SPITGYDIECKNKS--DSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSE 970
I GY + + S + S Q P SA ++++ TY I++ +
Sbjct: 680 F-IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGM 738
Query: 971 PSNELTITADEAAPDGPPQEVHLEPI---SSQSIRVTWKAPKKHLQNGIIRGYQIGYREY 1027
S T+ E AP PPQ V + + +S SI V+W P QNGII+ Y+I +
Sbjct: 739 DSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI----W 794
Query: 1028 STGGNFQFNI-ISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ 1077
G +F+I +VD + S + + L QY + V A AG G S+
Sbjct: 795 CLGNETRFHINKTVDAAIRSVI--IGGLFPGIQYRVEVAASTSAGVGVKSE 843
Score = 124 bits (312), Expect = 7e-28
Identities = 126/497 (25%), Positives = 210/497 (42%), Gaps = 58/497 (11%)
Query: 33 EVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPP 88
+V+ + T + C A G P T+ WY GE + D R + P+G+L
Sbjct: 55 DVIVSKGEPTTLNCKAEGRPTPTIEWY-KDGERVETDKDDPRSHRMLLPSGSL------- 106
Query: 89 SSFSTLIH-------DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNV 140
F ++H + +Y C A N G+ S++ ++ A+LR+ + D G
Sbjct: 107 -FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 165
Query: 141 AVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNED-GLYNYRCIT 199
A+ +C P + W+KD V + + G L I + + D G+Y C+
Sbjct: 166 AILECQPPRGHPE--PTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYT--CVG 221
Query: 200 RHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWL 259
+ GE R S+ A L V + P+ L ++ + + VE C+ G P+P RW
Sbjct: 222 TNM-VGE-RDSDPAELTVFE----RPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 275
Query: 260 KDNMPLELSGRFQ-KTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATI 318
KD+ L GR+ K L I+ +D G+Y+C NR G + L V+ P + +
Sbjct: 276 KDDADLP-RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV 334
Query: 319 SPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNG--EILNPGK----NVRITGINHENLIM 372
PR + G V+ C G + W + G +L P + N R + +L +
Sbjct: 335 RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 394
Query: 373 DHMVKSDGGAYQC--------FVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPV 424
++ +SD G Y C + K +L D V+ + P I+ + + ++
Sbjct: 395 TNIQRSDAGYYICQALTVAGSILAKAQLEVTD---VLTDRPPPIILQGPANQTLAVDGTA 451
Query: 425 SLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRC 484
L C G PLP I+W L + G R + I +G L I + ++ D G Y C
Sbjct: 452 LLKCKATGDPLPVISW-LKEGFTFPGRDPRAT--IQEQGT----LQIKNLRISDTGTYTC 504
Query: 485 TANNSAGVVLYQARINV 501
A +S+G + A ++V
Sbjct: 505 VATSSSGETSWSAVLDV 521
Score = 82.4 bits (202), Expect = 4e-15
Identities = 69/283 (24%), Positives = 119/283 (42%), Gaps = 42/283 (14%)
Query: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
+L CKA GDP P + W+K+ P D R +I G+ I+ ++ D+G Y+C+A +
Sbjct: 452 LLKCKATGDPLPVISWLKEGFTFPGR---DPRATIQEQGTLQIKNLRISDTGTYTCVATS 508
Query: 1364 NWGSDEIILNLQVQV----------------PPDQPRLTVSKTTSSSITLSWLPGDNGGS 1407
+ G L V PP +P++T T +S+TLSW PG G
Sbjct: 509 SSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVT--DVTKNSVTLSWQPGTPGTL 566
Query: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
YI++ +S+ S W + Y + L+ T Y F + A N G P +S
Sbjct: 567 PASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMS 626
Query: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGWNDGGCP--ITSFTL 1511
+ + + + Q +++ + VRL+ + W P I + +
Sbjct: 627 DPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRV 686
Query: 1512 EYRPF----GTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR 1549
YR T+ W + +S +L +L++ YE+++R
Sbjct: 687 MYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVR 729
Score = 82.0 bits (201), Expect = 5e-15
Identities = 148/616 (24%), Positives = 242/616 (39%), Gaps = 69/616 (11%)
Query: 689 PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSN 748
PP+ V P D G+ LNC AEG P PTI W + G V + + R+ +L +
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRM-LLPS 103
Query: 749 GSLLIKHVV-----EEDSGYYLCKVSNDVGADVSKSMYLTVKIPAM-ITSYPNTTLATQG 802
GSL +V + D G Y+C N +G VS++ L V + P + G
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 163
Query: 803 QKKEMSCTA-HGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSG 861
+ + C G + W+K+ I+ + R + + L I T + D+G
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK--------LMISNTRKSDAG 215
Query: 862 FFSCHAINSYGE-DRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDI 920
++C N GE D +LTV E P I V + + G+ T
Sbjct: 216 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT---- 271
Query: 921 ECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITAD 980
+ K D D + D+ + I + + A+NR+GK E S LT+ A
Sbjct: 272 -VRWKKDDADLPRGRYDIKDDY-TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA- 328
Query: 981 EAAPDGPPQEV--HLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQF--N 1036
PPQ V + I +Q VT+ K + + G + Q +
Sbjct: 329 ------PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS 382
Query: 1037 IISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEI-ITTTLEDVPSYPPENV 1095
SV +GD T+ N+ + + QA AG+ + ++ +T L D P PP +
Sbjct: 383 RCSVSPTGD---LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRP--PPIIL 437
Query: 1096 QAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTT---QPSLEL 1152
Q A +++++ + L K G VI W L +G ++ T Q +L++
Sbjct: 438 QGPAN--QTLAVDGTALLKCKATG--DPLPVISW--LKEGFTFPGRDPRATIQEQGTLQI 491
Query: 1153 DGLEKYTNYSIQVLAFTRAGDGVRS------EQIFTRTKE----DVPGPPAGVKAAAASA 1202
L + +A + +G+ S E T +K D+PGPP+ + +
Sbjct: 492 KNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTK 551
Query: 1203 SMVFVSWLP--PLKLNG---IIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQY 1257
+ V +SW P P L II ++ S+ + TV + + + Y + L N Y
Sbjct: 552 NSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTT----LYTVRGLRPNTIY 607
Query: 1258 SVWVVAVTSAGRGNSS 1273
V A+ G + S
Sbjct: 608 LFMVRAINPQGLSDPS 623
Score = 50.4 bits (119), Expect = 2e-05
Identities = 27/74 (36%), Positives = 34/74 (45%), Gaps = 5/74 (6%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C+ GDP P V+W KD P GR I + + I+ + D G Y CIA N G
Sbjct: 262 CQVQGDPQPTVRWKKDDADLPR-----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 316
Query: 1367 SDEIILNLQVQVPP 1380
E L V+ PP
Sbjct: 317 KMEASATLTVRAPP 330
Score = 48.1 bits (113), Expect = 8e-05
Identities = 36/143 (25%), Positives = 63/143 (44%), Gaps = 14/143 (9%)
Query: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMK 1301
D ++ RI + + +A G+ +S +TV +AP + + +
Sbjct: 290 DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV----RAPPQFVVRPRDQIVAQGR 345
Query: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKAEDSG 1355
+ PC+ G+P PAV W K+ G+ +L+ + R S+ G I ++ D+G
Sbjct: 346 TVTFPCETKGNPQPAVFWQKE--GSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAG 403
Query: 1356 YYSCIANNNWGSDEIILNLQVQV 1378
YY C A GS I+ Q++V
Sbjct: 404 YYICQALTVAGS--ILAKAQLEV 424
Score = 38.1 bits (87), Expect = 0.088
Identities = 27/88 (30%), Positives = 37/88 (42%), Gaps = 6/88 (6%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPS-LVTIDGRRSIFSNGS 1343
P RI+ V + L CKA G P+P ++W KD + R + +GS
Sbjct: 46 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 105
Query: 1344 -FIIRTVKAE----DSGYYSCIANNNWG 1366
F +R V D G Y C+A N G
Sbjct: 106 LFFLRIVHGRRSKPDEGSYVCVARNYLG 133
Score = 34.3 bits (77), Expect = 1.3
Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 9/66 (13%)
Query: 1304 VLPCKAV-GDPSPAVKWMKDSNGTPSLVTIDGRRSIFS--NGSFIIRTVKAEDSGYYSCI 1360
+L C+ G P P + W KD V ID + S G +I + D+G Y+C+
Sbjct: 167 ILECQPPRGHPEPTIYWKKDK------VRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 220
Query: 1361 ANNNWG 1366
N G
Sbjct: 221 GTNMVG 226
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 228 bits (582), Expect = 3e-59
Identities = 228/832 (27%), Positives = 352/832 (42%), Gaps = 87/832 (10%)
Query: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPI-LKGGSHRISQMITS 461
ED P+I+ S+ +VS EP +L C +G P PTI W D + + R +M+
Sbjct: 27 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
Query: 462 EGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRPMKNITAI 516
G++ + + + D G Y C A N G V A + V R P + A
Sbjct: 87 SGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA- 145
Query: 517 AGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
AG + C+ G+P +I W K+ + +++ G L +S+ +K D G YTC
Sbjct: 146 AGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRG-GKLMISNTRKS-DAGMYTC 203
Query: 576 NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVV-----VSGDLPITITW 630
S +TV P F R I Q V V V GD T+ W
Sbjct: 204 VGTNMVGERDSDPAELTVFERP-----TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRW 258
Query: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
+KD +P D D+T LRI G Y CIA N +E + L VR PP
Sbjct: 259 KKDDADLPRGRYDIKD--DYT--LRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 314
Query: 691 KFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQF--QPIALNGRIQVLSN 748
+FVV+PRDQ G+ V C +G P P + W+ +G+ F QP N R V
Sbjct: 315 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQ-KEGSQNLLFPNQPQQPNSRCSVSPT 373
Query: 749 GSLLIKHVVEEDSGYYLCKVSNDVGADVSKSM-----YLTVKIPAMITSYP-NTTLATQG 802
G L I ++ D+GYY+C+ G+ ++K+ LT + P +I P N TLA G
Sbjct: 374 GDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG 433
Query: 803 QKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 862
+ C A G+ ++ W KE R + + TLQI D+G
Sbjct: 434 TAL-LKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQ-------GTLQIKNLRISDTGT 485
Query: 863 FSCHAINSYGEDRGIIQLTVQE--------------PPDPPEIEIKDVKARTITLRWTMG 908
++C A +S GE L V E P P + ++ DV ++TL W G
Sbjct: 486 YTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPG 545
Query: 909 FDGNSPITGYDIEC--KNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRI 966
G P + Y IE ++ S+SW + + T+ + P++ Y + A N
Sbjct: 546 TPGTLPASAYIIEAFSQSVSNSWQTVAN----HVKTTLYTVRGLRPNTIYLFMVRAINPQ 601
Query: 967 GKSEPS--NELTITADEAAPDGPPQEVHLEP--------------ISSQSIRVTWKAPKK 1010
G S+PS ++ T D + P ++ ++ +++VTW +
Sbjct: 602 GLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDR- 660
Query: 1011 HLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSE-VYTLDNLNKFTQYGLVVQACNR 1069
Q I+GY++ YR+ ++G + ++D +E L NL K Y + V+
Sbjct: 661 --QPQFIQGYRVMYRQ-TSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFN 717
Query: 1070 AGTGPSSQEIITTTLEDVPSYPPENVQAIAT---SPESISISWSTLSKEALNGILQGFRV 1126
G S+ T E+ PS PP++V + + SIS+SW + NGI+Q +++
Sbjct: 718 EFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI 777
Query: 1127 IYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSE 1178
W + K + S+ + GL Y ++V A T AG GV+SE
Sbjct: 778 --WCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSE 827
Score = 157 bits (397), Expect = 1e-37
Identities = 206/851 (24%), Positives = 332/851 (39%), Gaps = 134/851 (15%)
Query: 504 PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL------PFNHRQVAFENNG 557
P + ++ G T ++C+ G P +I+WYK+ + P +HR + +G
Sbjct: 31 PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLL--PSG 88
Query: 558 TLKLSDV----QKEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIG 610
+L + + + DEG Y C N L + +S + S+ V + F Q + G
Sbjct: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEA-VSRNASLEVALLRDDFRQNPTDVVVAAG 147
Query: 611 QRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLR-----ISNLSLMHNG 665
+ + C G TI W+KD V ID+ + S+R ISN G
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDK--------VRIDDKEERISIRGGKLMISNTRKSDAG 199
Query: 666 NYTCIARNEAAAVEHQ-SQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWK 724
YTC+ N + ++L V P F+ +P +Q + +AV C +G P PT+ WK
Sbjct: 200 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
Query: 725 FSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV 784
A +P+ GR + + +L IK + D G Y+C N VG + S LTV
Sbjct: 260 -KDDADLPR-------GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK-MEASATLTV 310
Query: 785 KIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKE--DRII---NPEMARYLVST 839
+ P P + QG+ C G V W+KE ++ P+ S
Sbjct: 311 RAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSV 370
Query: 840 KEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQE--PPDPPEIEIKDVK 897
G+ I+ +Q R D+G++ C A+ G QL V + PP I ++
Sbjct: 371 SPTGDLTITNIQ-----RSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA 425
Query: 898 ARTITLRWTMGFDGNSPITGYDIECKNKSD-----SWDSAQRT------KDVSPQLNSAT 946
+T+ + DG + + +CK D SW T + + +
Sbjct: 426 NQTLAV------DGTALL-----KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQ 474
Query: 947 IIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPD---------GPPQEVHLEPIS 997
I ++ S T + A + G++ S L +T A GPP + + ++
Sbjct: 475 IKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVT 534
Query: 998 SQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKF 1057
S+ ++W+ Y I S ++Q V T+ +YT+ L
Sbjct: 535 KNSVTLSWQPGTPGTLPA--SAYIIEAFSQSVSNSWQTVANHVKTT----LYTVRGLRPN 588
Query: 1058 TQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQ-----------------AIAT 1100
T Y +V+A N G S +D+ S P + V +
Sbjct: 589 TIYLFMVRAINPQGLSDPSPMSDPVRTQDI-SPPAQGVDHRQVQKELGDVLVRLHNPVVL 647
Query: 1101 SPESISISWSTLSKEALNGILQGFRVIY-----------WANLMDGELGEIKNITTTQPS 1149
+P ++ ++W+ + +QG+RV+Y W NL D ++ T+ S
Sbjct: 648 TPTTVQVTWTV---DRQPQFIQGYRVMYRQTSGLQATSSWQNL-DAKV-------PTERS 696
Query: 1150 LELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG-PPAGVKAAAA---SASMV 1205
L L+K Y I+V + G+ SE RT E+ P PP V +++ +
Sbjct: 697 AVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI 756
Query: 1206 FVSWLPPLK--LNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVA 1263
VSW PP NGII++Y ++C S I L QY V V A
Sbjct: 757 SVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAA 816
Query: 1264 VTSAGRGNSSE 1274
TSAG G SE
Sbjct: 817 STSAGVGVKSE 827
Score = 145 bits (365), Expect = 5e-34
Identities = 206/831 (24%), Positives = 327/831 (39%), Gaps = 99/831 (11%)
Query: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
P + P V S G +L+C G + WY++GE + K+ +
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQVVLEDGTPKIISAFSEKVVSPA 421
+ ++ K D G+Y C R + +S ++V L ++ VV+
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALL--RDDFRQNPTDVVVAAG 147
Query: 422 EPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGG 480
EP L C +G P PTI W D K + I+ G L IS+++ D G
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKD-----KVRIDDKEERISIRG---GKLMISNTRKSDAG 199
Query: 481 VYRCTANNSAGV-VLYQARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWY 538
+Y C N G A + V P +R N + C+V G P +++W
Sbjct: 200 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
Query: 539 KNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQ-SVHVTVKVPP 597
K+ LP + +++ TL++ DEG Y C + + ++ + S +TV+ PP
Sbjct: 260 KDDADLPRGRYDI--KDDYTLRIKKTM-STDEGTYMC--IAENRVGKMEASATLTVRAPP 314
Query: 598 FIQPFEFPRFSI---GQRVFIPCVVVSGDLPITITWQKDGR-----PIPGSLGVTIDNID 649
Q PR I G+ V PC P + WQK+G P + ++
Sbjct: 315 --QFVVRPRDQIVAQGRTVTFPCETKGNPQP-AVFWQKEGSQNLLFPNQPQQPNSRCSVS 371
Query: 650 FTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQDGIY 703
T L I+N+ G Y C A A ++ ++QL V R PP + P +Q
Sbjct: 372 PTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAV 431
Query: 704 GKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGY 763
+L C A G P+P I W +G P P R + G+L IK++ D+G
Sbjct: 432 DGTALLKCKATGDPLPVISW-LKEGFTFPGRDP-----RATIQEQGTLQIKNLRISDTGT 485
Query: 764 YLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK 823
Y C ++ G + S S L V S G + T + + + W+
Sbjct: 486 YTCVATSSSG-ETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQP 544
Query: 824 EDRIINPEMARYLV---------STKEVGEEVISTLQILPTVREDSGF-FSCHAINSYG- 872
P A Y++ S + V V +TL + +R ++ + F AIN G
Sbjct: 545 GTPGTLPASA-YIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGL 603
Query: 873 EDRGIIQLTVQ-EPPDPP---------EIEIKDVKAR----------TITLRWTMGFDGN 912
D + V+ + PP + E+ DV R T+ + WT+
Sbjct: 604 SDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQ 663
Query: 913 SPITGYDIECKNKS--DSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSE 970
I GY + + S + S Q P SA ++++ TY I++ +
Sbjct: 664 F-IQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGM 722
Query: 971 PSNELTITADEAAPDGPPQEVHLEPI---SSQSIRVTWKAPKKHLQNGIIRGYQIGYREY 1027
S T+ E AP PPQ V + + +S SI V+W P QNGII+ Y+I +
Sbjct: 723 DSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKI----W 778
Query: 1028 STGGNFQFNI-ISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ 1077
G +F+I +VD + S + + L QY + V A AG G S+
Sbjct: 779 CLGNETRFHINKTVDAAIRSVI--IGGLFPGIQYRVEVAASTSAGVGVKSE 827
Score = 124 bits (312), Expect = 7e-28
Identities = 126/497 (25%), Positives = 210/497 (42%), Gaps = 58/497 (11%)
Query: 33 EVVFASTTGTLVPCPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPP 88
+V+ + T + C A G P T+ WY GE + D R + P+G+L
Sbjct: 39 DVIVSKGEPTTLNCKAEGRPTPTIEWY-KDGERVETDKDDPRSHRMLLPSGSL------- 90
Query: 89 SSFSTLIH-------DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNV 140
F ++H + +Y C A N G+ S++ ++ A+LR+ + D G
Sbjct: 91 -FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEP 149
Query: 141 AVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNED-GLYNYRCIT 199
A+ +C P + W+KD V + + G L I + + D G+Y C+
Sbjct: 150 AILECQPPRGHPE--PTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYT--CVG 205
Query: 200 RHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWL 259
+ GE R S+ A L V + P+ L ++ + + VE C+ G P+P RW
Sbjct: 206 TNM-VGE-RDSDPAELTVFE----RPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWK 259
Query: 260 KDNMPLELSGRFQ-KTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATI 318
KD+ L GR+ K L I+ +D G+Y+C NR G + L V+ P + +
Sbjct: 260 KDDADLP-RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVV 318
Query: 319 SPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNG--EILNPGK----NVRITGINHENLIM 372
PR + G V+ C G + W + G +L P + N R + +L +
Sbjct: 319 RPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTI 378
Query: 373 DHMVKSDGGAYQC--------FVRKDKLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPV 424
++ +SD G Y C + K +L D V+ + P I+ + + ++
Sbjct: 379 TNIQRSDAGYYICQALTVAGSILAKAQLEVTD---VLTDRPPPIILQGPANQTLAVDGTA 435
Query: 425 SLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRC 484
L C G PLP I+W L + G R + I +G L I + ++ D G Y C
Sbjct: 436 LLKCKATGDPLPVISW-LKEGFTFPGRDPRAT--IQEQGT----LQIKNLRISDTGTYTC 488
Query: 485 TANNSAGVVLYQARINV 501
A +S+G + A ++V
Sbjct: 489 VATSSSGETSWSAVLDV 505
Score = 82.4 bits (202), Expect = 4e-15
Identities = 69/283 (24%), Positives = 119/283 (42%), Gaps = 42/283 (14%)
Query: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
+L CKA GDP P + W+K+ P D R +I G+ I+ ++ D+G Y+C+A +
Sbjct: 436 LLKCKATGDPLPVISWLKEGFTFPGR---DPRATIQEQGTLQIKNLRISDTGTYTCVATS 492
Query: 1364 NWGSDEIILNLQVQV----------------PPDQPRLTVSKTTSSSITLSWLPGDNGGS 1407
+ G L V PP +P++T T +S+TLSW PG G
Sbjct: 493 SSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVT--DVTKNSVTLSWQPGTPGTL 550
Query: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
YI++ +S+ S W + Y + L+ T Y F + A N G P +S
Sbjct: 551 PASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMS 610
Query: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGWNDGGCP--ITSFTL 1511
+ + + + Q +++ + VRL+ + W P I + +
Sbjct: 611 DPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRV 670
Query: 1512 EYRPF----GTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR 1549
YR T+ W + +S +L +L++ YE+++R
Sbjct: 671 MYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVR 713
Score = 82.0 bits (201), Expect = 5e-15
Identities = 148/616 (24%), Positives = 242/616 (39%), Gaps = 69/616 (11%)
Query: 689 PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSN 748
PP+ V P D G+ LNC AEG P PTI W + G V + + R+ +L +
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEW-YKDGERVETDKDDPRSHRM-LLPS 87
Query: 749 GSLLIKHVV-----EEDSGYYLCKVSNDVGADVSKSMYLTVKIPAM-ITSYPNTTLATQG 802
GSL +V + D G Y+C N +G VS++ L V + P + G
Sbjct: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAG 147
Query: 803 QKKEMSCTA-HGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSG 861
+ + C G + W+K+ I+ + R + + L I T + D+G
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGK--------LMISNTRKSDAG 199
Query: 862 FFSCHAINSYGE-DRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDI 920
++C N GE D +LTV E P I V + + G+ T
Sbjct: 200 MYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT---- 255
Query: 921 ECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITAD 980
+ K D D + D+ + I + + A+NR+GK E S LT+ A
Sbjct: 256 -VRWKKDDADLPRGRYDIKDDY-TLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA- 312
Query: 981 EAAPDGPPQEV--HLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQF--N 1036
PPQ V + I +Q VT+ K + + G + Q +
Sbjct: 313 ------PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNS 366
Query: 1037 IISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEI-ITTTLEDVPSYPPENV 1095
SV +GD T+ N+ + + QA AG+ + ++ +T L D P PP +
Sbjct: 367 RCSVSPTGD---LTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRP--PPIIL 421
Query: 1096 QAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTT---QPSLEL 1152
Q A +++++ + L K G VI W L +G ++ T Q +L++
Sbjct: 422 QGPAN--QTLAVDGTALLKCKATG--DPLPVISW--LKEGFTFPGRDPRATIQEQGTLQI 475
Query: 1153 DGLEKYTNYSIQVLAFTRAGDGVRS------EQIFTRTKE----DVPGPPAGVKAAAASA 1202
L + +A + +G+ S E T +K D+PGPP+ + +
Sbjct: 476 KNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTK 535
Query: 1203 SMVFVSWLP--PLKLNG---IIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQY 1257
+ V +SW P P L II ++ S+ + TV + + + Y + L N Y
Sbjct: 536 NSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTT----LYTVRGLRPNTIY 591
Query: 1258 SVWVVAVTSAGRGNSS 1273
V A+ G + S
Sbjct: 592 LFMVRAINPQGLSDPS 607
Score = 50.4 bits (119), Expect = 2e-05
Identities = 27/74 (36%), Positives = 34/74 (45%), Gaps = 5/74 (6%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C+ GDP P V+W KD P GR I + + I+ + D G Y CIA N G
Sbjct: 246 CQVQGDPQPTVRWKKDDADLPR-----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 300
Query: 1367 SDEIILNLQVQVPP 1380
E L V+ PP
Sbjct: 301 KMEASATLTVRAPP 314
Score = 48.1 bits (113), Expect = 8e-05
Identities = 36/143 (25%), Positives = 63/143 (44%), Gaps = 14/143 (9%)
Query: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMK 1301
D ++ RI + + +A G+ +S +TV +AP + + +
Sbjct: 274 DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV----RAPPQFVVRPRDQIVAQGR 329
Query: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKAEDSG 1355
+ PC+ G+P PAV W K+ G+ +L+ + R S+ G I ++ D+G
Sbjct: 330 TVTFPCETKGNPQPAVFWQKE--GSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAG 387
Query: 1356 YYSCIANNNWGSDEIILNLQVQV 1378
YY C A GS I+ Q++V
Sbjct: 388 YYICQALTVAGS--ILAKAQLEV 408
Score = 38.1 bits (87), Expect = 0.088
Identities = 27/88 (30%), Positives = 37/88 (42%), Gaps = 6/88 (6%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPS-LVTIDGRRSIFSNGS 1343
P RI+ V + L CKA G P+P ++W KD + R + +GS
Sbjct: 30 PPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGS 89
Query: 1344 -FIIRTVKAE----DSGYYSCIANNNWG 1366
F +R V D G Y C+A N G
Sbjct: 90 LFFLRIVHGRRSKPDEGSYVCVARNYLG 117
Score = 34.3 bits (77), Expect = 1.3
Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 9/66 (13%)
Query: 1304 VLPCKAV-GDPSPAVKWMKDSNGTPSLVTIDGRRSIFS--NGSFIIRTVKAEDSGYYSCI 1360
+L C+ G P P + W KD V ID + S G +I + D+G Y+C+
Sbjct: 151 ILECQPPRGHPEPTIYWKKDK------VRIDDKEERISIRGGKLMISNTRKSDAGMYTCV 204
Query: 1361 ANNNWG 1366
N G
Sbjct: 205 GTNMVG 210
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 226 bits (577), Expect = 1e-58
Identities = 259/974 (26%), Positives = 403/974 (41%), Gaps = 135/974 (13%)
Query: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--------TLDDDPILKGGSHR 454
ED P+I+ S+ +VS EP +L C +G P PTI W T DDP SHR
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDP----RSHR 80
Query: 455 ISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRP 509
M+ G++ + + R D GVY C A N G V + A + V R P
Sbjct: 81 ---MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 510 MKNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568
+ A+ G + C+ G+P +I W K+ + L ++ G L ++ +K
Sbjct: 138 SDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKS- 194
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTV-KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
D G+Y C S+ +TV + P F++ ++ C +P T
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-T 253
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
+ W+KD +P S D+ +L+I ++ G+YTC+A N E + L V+
Sbjct: 254 VRWRKDDGELPKSRYEIRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Query: 688 V---PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP-QFQPIALNGRI 743
V PP FVV+PRDQ G+ V C A G P P I W+ + +QP + R
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 744 QVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV------KIPAMITSYP-NT 796
V G L I +V D GYY+C+ N G+ ++K+ YL V + P +I P N
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKA-YLEVTDVIADRPPPVIRQGPVNQ 428
Query: 797 TLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV 856
T+A G +SC A G + W K+ +++ + +R + E G LQI
Sbjct: 429 TVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENG-----VLQIRYAK 480
Query: 857 REDSGFFSCHAINSYGEDRGIIQLTVQE----------------PPDPPEIEIKDVKART 900
D+G ++C A GE + VQE P P + E+ DV T
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
Query: 901 ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRM 960
+TL W + + T Y IE + + S+ +T + + ++ I + P++ Y +
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLV 598
Query: 961 YAKNRIGKSEPSN-ELTITADEAAPDGPPQE------------VHLE---PISSQSIRVT 1004
A N G S+PS + + P + +HL +SS SI V
Sbjct: 599 RAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVH 658
Query: 1005 WKAPKKHLQNGIIRGYQIGYREYSTG-GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLV 1063
W + Q+ I+GY+I YR G + + V T + V + +L K Y +
Sbjct: 659 WTVDQ---QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIK 714
Query: 1064 VQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT--SPESISISWSTLSKEALNGIL 1121
+ G S+ TLE+ PS PP+ V + +I +SW ++ NG++
Sbjct: 715 ARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMV 774
Query: 1122 QGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIF 1181
Q ++V W + K + + S+ + L YS++V A T AG GV+SE F
Sbjct: 775 QEYKV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQF 832
Query: 1182 TRTKEDVPGPP-----------------------AGVKAAAASASMVFVSWL--PPLKLN 1216
+ D G P AG+ AA MVF WL K N
Sbjct: 833 IQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRN 890
Query: 1217 GI------IRKYT------VFCSHPYPTVISEFE-ASPDSFSYRIPNLSRNRQYSVWVVA 1263
G+ IRK T S P +++ E A+ + PN N ++ ++
Sbjct: 891 GLTSTYAGIRKVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNN--HNDCSIS 948
Query: 1264 VTSAGRGNSSEIIT 1277
+AG GNS +T
Sbjct: 949 CCTAGNGNSDSNLT 962
Score = 131 bits (330), Expect = 6e-30
Identities = 192/855 (22%), Positives = 339/855 (39%), Gaps = 106/855 (12%)
Query: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
P + P + S G +L+C G + WY+ GE + K+ +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQV-VLEDGTPKIISAFSEKVVSP 420
+ ++ + D G Y C R + +S ++V +L D S+ +V+
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVMVAV 144
Query: 421 AEPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
EP + C +G P PTI+W D P+ + IT G L I+ ++ D
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL-----DDKDERITIRG---GKLMITYTRKSDA 196
Query: 480 GVYRCTANNSAGVVLYQ-ARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKW 537
G Y C N G + A + V P+ ++ N+ C G P +++W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 538 YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVK 594
K+ LP + ++ ++ TLK+ V D G YTC N++ + + S + +V V +
Sbjct: 257 RKDDGELPKSRYEI--RDDHTLKIRKVTAG-DMGSYTCVAENMVGKAEASATLTVQVGSE 313
Query: 595 VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG--------RPIPGSLGVTID 646
P F+ ++G+ V C P I W+++G +P S ++
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 647 NIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQD 700
T L I+N+ G Y C N A ++ ++ L V R PP P +Q
Sbjct: 373 Q---TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 701 GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEED 760
+L+C A G PVPTI+W+ K + Q + RI+ L NG L I++ D
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWR--KDGVLVSTQ----DSRIKQLENGVLQIRYAKLGD 483
Query: 761 SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTT----LATQGQKKEMSCTAHGEKP 816
+G Y C S G + + S Y+ V+ + P T + + K E+ T
Sbjct: 484 TGRYTCIASTPSG-EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNT 540
Query: 817 IIVRWEKE--------DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-FSCHA 867
+ + W+ II S + V E V + + ++ ++ + F A
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
Query: 868 INSYG------------------EDRGIIQLTVQEPPDPPEIEIKD---VKARTITLRWT 906
N+YG +G+ VQ + + + + + +I + WT
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 907 MGFDGNSPITGYDIECK-NKSDSWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYA-K 963
+ + I GY I + + ++ +S +V +P NS I D+ Y I+
Sbjct: 661 VD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 964 NRIGKSEPSNELTITADEAAPDGPPQEVHLEPI--SSQSIRVTWKAPKKHLQNGIIRGYQ 1021
N ++ + T +E AP PPQ V + + +I V+W+ P + QNG+++ Y+
Sbjct: 720 NEFQGADSEIKFAKTLEE-APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYK 778
Query: 1022 IGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ-EII 1080
+ + G +++ I+ G + + L +Y + V A AG+G S+ + I
Sbjct: 779 V----WCLGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFI 833
Query: 1081 TTTLEDVPSYPPENV 1095
P P + V
Sbjct: 834 QLDAHGNPVSPEDQV 848
Score = 117 bits (293), Expect = 1e-25
Identities = 129/490 (26%), Positives = 194/490 (39%), Gaps = 65/490 (13%)
Query: 46 CPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPPSSFSTLIH----- 96
C A G P T+ WY GE + D R + P+G+L F ++H
Sbjct: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLPSGSL--------FFLRIVHGRKSR 100
Query: 97 --DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEA 153
+ Y C A N G+ S + ++ A+LR+ + D G AV +C P
Sbjct: 101 PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE 160
Query: 154 YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA 213
+SW+KD L + G L I + D Y C+ + GE R+S A
Sbjct: 161 --PTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTN-MVGE-RESEVA 215
Query: 214 RL-------FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
L FV P+N A ++ D E C+A G P P RW KD+ L
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDS-----------AEFKCEARGDPVPTVRWRKDDGELP 264
Query: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVK---QPLKATISPRKV 323
S + L I + D GSY C N G A+ L V+ +P + PR
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324
Query: 324 KSSVGSQVSLSCSVTGTEDQELSWYRNG------EILNPGKNVRITGINHENLIMDHMVK 377
++G V+ C TG + W R G P + R + +L + ++ +
Sbjct: 325 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 384
Query: 378 SDGGAYQCFVRK--DKLSAQDYVQV--VLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKG 432
SD G Y C + + Y++V V+ D P +I + V+ L C G
Sbjct: 385 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATG 444
Query: 433 TPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV 492
+P+PTI W D ++ RI Q+ E V L I +++ D G Y C A+ +G
Sbjct: 445 SPVPTILWR-KDGVLVSTQDSRIKQL---ENGV---LQIRYAKLGDTGRYTCIASTPSGE 497
Query: 493 VLYQARINVR 502
+ A I V+
Sbjct: 498 ATWSAYIEVQ 507
Score = 103 bits (258), Expect = 1e-21
Identities = 126/493 (25%), Positives = 188/493 (38%), Gaps = 46/493 (9%)
Query: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL---------IENIRPS--D 287
G+ L CKA G P P W K +E ++ LL I + R S D
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 288 SGSYVCEVSNRYGTAKVIGRLYVKQPLKATI--SPRKVKSSVGSQVSLSCS-VTGTEDQE 344
G YVC N G A L+ +P V +VG + C G +
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 345 LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLED 404
+SW ++G L+ K+ RIT I L++ + KSD G Y C + V +
Sbjct: 163 ISWKKDGSPLD-DKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
Query: 405 GTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN 464
P + S V+ + C +G P+PT+ W DD + K + I T
Sbjct: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDDHT---- 275
Query: 465 VVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS-----IRPMKNITAIAGR 519
L I D G Y C A N G A + V+ + ++P + A+ GR
Sbjct: 276 ----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVAL-GR 330
Query: 520 DTYIHCRVIGYPYYSIKWYK--NSNLL-----PFNHRQVAFENNGTLKLSDVQKEVDEGE 572
C G P +I W + + NLL P + + + G L +++VQ+ D G
Sbjct: 331 TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGY 389
Query: 573 YTCNVL-VQPQLSTSQSVHVTVKV----PPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
Y C L V + T + VT + PP I+ + F+ V +G T
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 449
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
I W+KDG + + I ++ L+I L G YTCIA + + + V+
Sbjct: 450 ILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Query: 688 VPPKFVVQPRDQD 700
V PR D
Sbjct: 508 EFGVPVQPPRPTD 520
Score = 97.8 bits (242), Expect = 9e-20
Identities = 120/465 (25%), Positives = 186/465 (40%), Gaps = 57/465 (12%)
Query: 172 RFLITSTGALYIKDVQN-----EDGLYNYRCITRHRYTGETRQSNSAR--LFVSDPANSA 224
R L+ S +++ V ++G+Y C+ R+ Y GE N++ + D
Sbjct: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYV--CVARN-YLGEAVSHNASLEVAILRDDFRQN 136
Query: 225 PSILDGFDHRKAMAGQRVELPCKA-LGHPEPDYRWLKDNMPLELSGRFQKTVTG--LLIE 281
PS + G+ + C+ GHPEP W KD PL+ + T+ G L+I
Sbjct: 137 PSDV------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMIT 189
Query: 282 NIRPSDSGSYVCEVSNRYGTAK-VIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGT 340
R SD+G YVC +N G + + L V + P + +V C G
Sbjct: 190 YTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD 249
Query: 341 EDQELSWYR-NGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQC----FVRKDKLSAQ 395
+ W + +GE+ +R + L + + D G+Y C V K + SA
Sbjct: 250 PVPTVRWRKDDGELPKSRYEIR----DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASAT 305
Query: 396 DYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPIL------K 449
VQV E P + ++VV+ V+ C G P P I W + L
Sbjct: 306 LTVQVGSE--PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
Query: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV------RG 503
S R S T + L I++ Q D G Y C N AG ++ +A + V R
Sbjct: 364 QSSSRFSVSQTGD------LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417
Query: 504 PASIR--PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL 561
P IR P+ A+ G + C G P +I W K+ L+ ++ NG L++
Sbjct: 418 PPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 476
Query: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPR 606
K D G YTC + P + S + ++V F P + PR
Sbjct: 477 R-YAKLGDTGRYTC-IASTPSGEATWSAY--IEVQEFGVPVQPPR 517
Score = 82.4 bits (202), Expect = 4e-15
Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 41/319 (12%)
Query: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
VL C A G P P + W KD + T D R NG IR K D+G Y+CIA+
Sbjct: 437 VLSCVATGSPVPTILWRKDG---VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 1364 NWGSDEIILNLQVQ---VPPDQPRLT-------------VSKTTSSSITLSWLPGDNGGS 1407
G ++VQ VP PR T V+ + +++TLSW P N G+
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
Query: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
+ YI++ +S + W + + + ++ LK Y F + A N G P +IS
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 613
Query: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGW--NDGGCPITSFTL 1511
+ ++ + + Q +++ + + L+ + W + I + +
Sbjct: 614 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 673
Query: 1512 EYRP----FGTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR-VCNSAGCAEKQANFAT 1565
YRP G + W + RT S ++ DL++ YE++ R N A+ + FA
Sbjct: 674 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
Query: 1566 LNYDGSTIPPLIKSVVQNE 1584
+ + PP +V +N+
Sbjct: 734 TLEEAPSAPPQGVTVSKND 752
Score = 53.9 bits (128), Expect = 2e-06
Identities = 31/81 (38%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C+A GDP P V+W KD P R I + + IR V A D G Y+C+A N G
Sbjct: 244 CEARGDPVPTVRWRKDDGELPK-----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 1367 SDEIILNLQVQVPPDQPRLTV 1387
E L VQV + P V
Sbjct: 299 KAEASATLTVQVGSEPPHFVV 319
Score = 47.8 bits (112), Expect = 1e-04
Identities = 79/383 (20%), Positives = 144/383 (37%), Gaps = 57/383 (14%)
Query: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMK 1301
D + +I ++ S VA G+ +S +TV+ ++ P ++ V +
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALG-R 330
Query: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKAEDSG 1355
+ C+A G+P PA+ W ++ G+ +L+ R S+ G I V+ D G
Sbjct: 331 TVTFQCEATGNPQPAIFWRRE--GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 388
Query: 1356 YYSCIANNNWGSDEIILNLQV-QVPPDQPRLTVSK-TTSSSITLSWLPGDNGGSSIRGYI 1413
YY C N GS L+V V D+P + + + ++ + G+ + +
Sbjct: 389 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD-------GTFVLSCV 441
Query: 1414 LQYSEDNSEQWGSFPISPSERSYRLENL----------KCGTWYKFTLTAQNGVGPGRIS 1463
S + W + S + R++ L K G ++T A G S
Sbjct: 442 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501
Query: 1464 EIIEAKTLG--KEPQFSKEQELFASI----NTTRVRLNLI--GW----NDGGCPITSFTL 1511
IE + G +P + L S T V N + W N G P TS+ +
Sbjct: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-TSYII 560
Query: 1512 E-YRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDG 1570
E + + W T +++ + L+ Y +R N+ G ++
Sbjct: 561 EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD------------ 608
Query: 1571 STIPPLIKSVVQNEEGLTTNEGL 1593
P I V+ ++ L T++G+
Sbjct: 609 ---PSQISDPVKTQDVLPTSQGV 628
Score = 35.8 bits (81), Expect = 0.43
Identities = 37/171 (21%), Positives = 66/171 (38%), Gaps = 14/171 (8%)
Query: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
G P P + W KD G+P + R G +I + D+G Y C+ N G E
Sbjct: 157 GHPEPTISWKKD--GSP--LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
Query: 1371 -ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG---YILQYSEDNSEQWGS 1426
+ L V P V + ++ ++T+ RG +++ +D+ E S
Sbjct: 213 EVAELTVLERPS----FVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 1427 FPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQF 1477
+ + ++ + G +T A+N VG S + + + P F
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Score = 35.0 bits (79), Expect = 0.74
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS---IFSN 1341
P RI+ + + L CKA G P+P ++W K G D RS + +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--GGERVETDKDDPRSHRMLLPS 85
Query: 1342 GS-FIIRTVKAE----DSGYYSCIANNNWG 1366
GS F +R V D G Y C+A N G
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 226 bits (577), Expect = 1e-58
Identities = 259/974 (26%), Positives = 403/974 (41%), Gaps = 135/974 (13%)
Query: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--------TLDDDPILKGGSHR 454
ED P+I+ S+ +VS EP +L C +G P PTI W T DDP SHR
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDP----RSHR 80
Query: 455 ISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRP 509
M+ G++ + + R D GVY C A N G V + A + V R P
Sbjct: 81 ---MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 510 MKNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568
+ A+ G + C+ G+P +I W K+ + L ++ G L ++ +K
Sbjct: 138 SDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKS- 194
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTV-KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
D G+Y C S+ +TV + P F++ ++ C +P T
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-T 253
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
+ W+KD +P S D+ +L+I ++ G+YTC+A N E + L V+
Sbjct: 254 VRWRKDDGELPKSRYEIRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Query: 688 V---PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP-QFQPIALNGRI 743
V PP FVV+PRDQ G+ V C A G P P I W+ + +QP + R
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 744 QVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV------KIPAMITSYP-NT 796
V G L I +V D GYY+C+ N G+ ++K+ YL V + P +I P N
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKA-YLEVTDVIADRPPPVIRQGPVNQ 428
Query: 797 TLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV 856
T+A G +SC A G + W K+ +++ + +R + E G LQI
Sbjct: 429 TVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENG-----VLQIRYAK 480
Query: 857 REDSGFFSCHAINSYGEDRGIIQLTVQE----------------PPDPPEIEIKDVKART 900
D+G ++C A GE + VQE P P + E+ DV T
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
Query: 901 ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRM 960
+TL W + + T Y IE + + S+ +T + + ++ I + P++ Y +
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLV 598
Query: 961 YAKNRIGKSEPSN-ELTITADEAAPDGPPQE------------VHLE---PISSQSIRVT 1004
A N G S+PS + + P + +HL +SS SI V
Sbjct: 599 RAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVH 658
Query: 1005 WKAPKKHLQNGIIRGYQIGYREYSTG-GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLV 1063
W + Q+ I+GY+I YR G + + V T + V + +L K Y +
Sbjct: 659 WTVDQ---QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIK 714
Query: 1064 VQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT--SPESISISWSTLSKEALNGIL 1121
+ G S+ TLE+ PS PP+ V + +I +SW ++ NG++
Sbjct: 715 ARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMV 774
Query: 1122 QGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIF 1181
Q ++V W + K + + S+ + L YS++V A T AG GV+SE F
Sbjct: 775 QEYKV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQF 832
Query: 1182 TRTKEDVPGPP-----------------------AGVKAAAASASMVFVSWL--PPLKLN 1216
+ D G P AG+ AA MVF WL K N
Sbjct: 833 IQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRN 890
Query: 1217 GI------IRKYT------VFCSHPYPTVISEFE-ASPDSFSYRIPNLSRNRQYSVWVVA 1263
G+ IRK T S P +++ E A+ + PN N ++ ++
Sbjct: 891 GLTSTYAGIRKVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNN--HNDCSIS 948
Query: 1264 VTSAGRGNSSEIIT 1277
+AG GNS +T
Sbjct: 949 CCTAGNGNSDSNLT 962
Score = 131 bits (330), Expect = 6e-30
Identities = 192/855 (22%), Positives = 339/855 (39%), Gaps = 106/855 (12%)
Query: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
P + P + S G +L+C G + WY+ GE + K+ +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQV-VLEDGTPKIISAFSEKVVSP 420
+ ++ + D G Y C R + +S ++V +L D S+ +V+
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVMVAV 144
Query: 421 AEPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
EP + C +G P PTI+W D P+ + IT G L I+ ++ D
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL-----DDKDERITIRG---GKLMITYTRKSDA 196
Query: 480 GVYRCTANNSAGVVLYQ-ARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKW 537
G Y C N G + A + V P+ ++ N+ C G P +++W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 538 YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVK 594
K+ LP + ++ ++ TLK+ V D G YTC N++ + + S + +V V +
Sbjct: 257 RKDDGELPKSRYEI--RDDHTLKIRKVTAG-DMGSYTCVAENMVGKAEASATLTVQVGSE 313
Query: 595 VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG--------RPIPGSLGVTID 646
P F+ ++G+ V C P I W+++G +P S ++
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 647 NIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQD 700
T L I+N+ G Y C N A ++ ++ L V R PP P +Q
Sbjct: 373 Q---TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 701 GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEED 760
+L+C A G PVPTI+W+ K + Q + RI+ L NG L I++ D
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWR--KDGVLVSTQ----DSRIKQLENGVLQIRYAKLGD 483
Query: 761 SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTT----LATQGQKKEMSCTAHGEKP 816
+G Y C S G + + S Y+ V+ + P T + + K E+ T
Sbjct: 484 TGRYTCIASTPSG-EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNT 540
Query: 817 IIVRWEKE--------DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-FSCHA 867
+ + W+ II S + V E V + + ++ ++ + F A
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
Query: 868 INSYG------------------EDRGIIQLTVQEPPDPPEIEIKD---VKARTITLRWT 906
N+YG +G+ VQ + + + + + +I + WT
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 907 MGFDGNSPITGYDIECK-NKSDSWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYA-K 963
+ + I GY I + + ++ +S +V +P NS I D+ Y I+
Sbjct: 661 VD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 964 NRIGKSEPSNELTITADEAAPDGPPQEVHLEPI--SSQSIRVTWKAPKKHLQNGIIRGYQ 1021
N ++ + T +E AP PPQ V + + +I V+W+ P + QNG+++ Y+
Sbjct: 720 NEFQGADSEIKFAKTLEE-APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYK 778
Query: 1022 IGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ-EII 1080
+ + G +++ I+ G + + L +Y + V A AG+G S+ + I
Sbjct: 779 V----WCLGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFI 833
Query: 1081 TTTLEDVPSYPPENV 1095
P P + V
Sbjct: 834 QLDAHGNPVSPEDQV 848
Score = 117 bits (293), Expect = 1e-25
Identities = 129/490 (26%), Positives = 194/490 (39%), Gaps = 65/490 (13%)
Query: 46 CPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPPSSFSTLIH----- 96
C A G P T+ WY GE + D R + P+G+L F ++H
Sbjct: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLPSGSL--------FFLRIVHGRKSR 100
Query: 97 --DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEA 153
+ Y C A N G+ S + ++ A+LR+ + D G AV +C P
Sbjct: 101 PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE 160
Query: 154 YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA 213
+SW+KD L + G L I + D Y C+ + GE R+S A
Sbjct: 161 --PTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTN-MVGE-RESEVA 215
Query: 214 RL-------FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
L FV P+N A ++ D E C+A G P P RW KD+ L
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDS-----------AEFKCEARGDPVPTVRWRKDDGELP 264
Query: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVK---QPLKATISPRKV 323
S + L I + D GSY C N G A+ L V+ +P + PR
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324
Query: 324 KSSVGSQVSLSCSVTGTEDQELSWYRNG------EILNPGKNVRITGINHENLIMDHMVK 377
++G V+ C TG + W R G P + R + +L + ++ +
Sbjct: 325 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 384
Query: 378 SDGGAYQCFVRK--DKLSAQDYVQV--VLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKG 432
SD G Y C + + Y++V V+ D P +I + V+ L C G
Sbjct: 385 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATG 444
Query: 433 TPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV 492
+P+PTI W D ++ RI Q+ E V L I +++ D G Y C A+ +G
Sbjct: 445 SPVPTILWR-KDGVLVSTQDSRIKQL---ENGV---LQIRYAKLGDTGRYTCIASTPSGE 497
Query: 493 VLYQARINVR 502
+ A I V+
Sbjct: 498 ATWSAYIEVQ 507
Score = 103 bits (258), Expect = 1e-21
Identities = 126/493 (25%), Positives = 188/493 (38%), Gaps = 46/493 (9%)
Query: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL---------IENIRPS--D 287
G+ L CKA G P P W K +E ++ LL I + R S D
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 288 SGSYVCEVSNRYGTAKVIGRLYVKQPLKATI--SPRKVKSSVGSQVSLSCS-VTGTEDQE 344
G YVC N G A L+ +P V +VG + C G +
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 345 LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLED 404
+SW ++G L+ K+ RIT I L++ + KSD G Y C + V +
Sbjct: 163 ISWKKDGSPLD-DKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
Query: 405 GTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN 464
P + S V+ + C +G P+PT+ W DD + K + I T
Sbjct: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDDHT---- 275
Query: 465 VVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS-----IRPMKNITAIAGR 519
L I D G Y C A N G A + V+ + ++P + A+ GR
Sbjct: 276 ----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVAL-GR 330
Query: 520 DTYIHCRVIGYPYYSIKWYK--NSNLL-----PFNHRQVAFENNGTLKLSDVQKEVDEGE 572
C G P +I W + + NLL P + + + G L +++VQ+ D G
Sbjct: 331 TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGY 389
Query: 573 YTCNVL-VQPQLSTSQSVHVTVKV----PPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
Y C L V + T + VT + PP I+ + F+ V +G T
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 449
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
I W+KDG + + I ++ L+I L G YTCIA + + + V+
Sbjct: 450 ILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Query: 688 VPPKFVVQPRDQD 700
V PR D
Sbjct: 508 EFGVPVQPPRPTD 520
Score = 97.8 bits (242), Expect = 9e-20
Identities = 120/465 (25%), Positives = 186/465 (40%), Gaps = 57/465 (12%)
Query: 172 RFLITSTGALYIKDVQN-----EDGLYNYRCITRHRYTGETRQSNSAR--LFVSDPANSA 224
R L+ S +++ V ++G+Y C+ R+ Y GE N++ + D
Sbjct: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYV--CVARN-YLGEAVSHNASLEVAILRDDFRQN 136
Query: 225 PSILDGFDHRKAMAGQRVELPCKA-LGHPEPDYRWLKDNMPLELSGRFQKTVTG--LLIE 281
PS + G+ + C+ GHPEP W KD PL+ + T+ G L+I
Sbjct: 137 PSDV------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMIT 189
Query: 282 NIRPSDSGSYVCEVSNRYGTAK-VIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGT 340
R SD+G YVC +N G + + L V + P + +V C G
Sbjct: 190 YTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD 249
Query: 341 EDQELSWYR-NGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQC----FVRKDKLSAQ 395
+ W + +GE+ +R + L + + D G+Y C V K + SA
Sbjct: 250 PVPTVRWRKDDGELPKSRYEIR----DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASAT 305
Query: 396 DYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPIL------K 449
VQV E P + ++VV+ V+ C G P P I W + L
Sbjct: 306 LTVQVGSE--PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
Query: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV------RG 503
S R S T + L I++ Q D G Y C N AG ++ +A + V R
Sbjct: 364 QSSSRFSVSQTGD------LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417
Query: 504 PASIR--PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL 561
P IR P+ A+ G + C G P +I W K+ L+ ++ NG L++
Sbjct: 418 PPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 476
Query: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPR 606
K D G YTC + P + S + ++V F P + PR
Sbjct: 477 R-YAKLGDTGRYTC-IASTPSGEATWSAY--IEVQEFGVPVQPPR 517
Score = 82.4 bits (202), Expect = 4e-15
Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 41/319 (12%)
Query: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
VL C A G P P + W KD + T D R NG IR K D+G Y+CIA+
Sbjct: 437 VLSCVATGSPVPTILWRKDG---VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 1364 NWGSDEIILNLQVQ---VPPDQPRLT-------------VSKTTSSSITLSWLPGDNGGS 1407
G ++VQ VP PR T V+ + +++TLSW P N G+
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
Query: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
+ YI++ +S + W + + + ++ LK Y F + A N G P +IS
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 613
Query: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGW--NDGGCPITSFTL 1511
+ ++ + + Q +++ + + L+ + W + I + +
Sbjct: 614 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 673
Query: 1512 EYRP----FGTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR-VCNSAGCAEKQANFAT 1565
YRP G + W + RT S ++ DL++ YE++ R N A+ + FA
Sbjct: 674 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
Query: 1566 LNYDGSTIPPLIKSVVQNE 1584
+ + PP +V +N+
Sbjct: 734 TLEEAPSAPPQGVTVSKND 752
Score = 53.9 bits (128), Expect = 2e-06
Identities = 31/81 (38%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C+A GDP P V+W KD P R I + + IR V A D G Y+C+A N G
Sbjct: 244 CEARGDPVPTVRWRKDDGELPK-----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 1367 SDEIILNLQVQVPPDQPRLTV 1387
E L VQV + P V
Sbjct: 299 KAEASATLTVQVGSEPPHFVV 319
Score = 47.8 bits (112), Expect = 1e-04
Identities = 79/383 (20%), Positives = 144/383 (37%), Gaps = 57/383 (14%)
Query: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMK 1301
D + +I ++ S VA G+ +S +TV+ ++ P ++ V +
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALG-R 330
Query: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKAEDSG 1355
+ C+A G+P PA+ W ++ G+ +L+ R S+ G I V+ D G
Sbjct: 331 TVTFQCEATGNPQPAIFWRRE--GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 388
Query: 1356 YYSCIANNNWGSDEIILNLQV-QVPPDQPRLTVSK-TTSSSITLSWLPGDNGGSSIRGYI 1413
YY C N GS L+V V D+P + + + ++ + G+ + +
Sbjct: 389 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD-------GTFVLSCV 441
Query: 1414 LQYSEDNSEQWGSFPISPSERSYRLENL----------KCGTWYKFTLTAQNGVGPGRIS 1463
S + W + S + R++ L K G ++T A G S
Sbjct: 442 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501
Query: 1464 EIIEAKTLG--KEPQFSKEQELFASI----NTTRVRLNLI--GW----NDGGCPITSFTL 1511
IE + G +P + L S T V N + W N G P TS+ +
Sbjct: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-TSYII 560
Query: 1512 E-YRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDG 1570
E + + W T +++ + L+ Y +R N+ G ++
Sbjct: 561 EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD------------ 608
Query: 1571 STIPPLIKSVVQNEEGLTTNEGL 1593
P I V+ ++ L T++G+
Sbjct: 609 ---PSQISDPVKTQDVLPTSQGV 628
Score = 35.8 bits (81), Expect = 0.43
Identities = 37/171 (21%), Positives = 66/171 (38%), Gaps = 14/171 (8%)
Query: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
G P P + W KD G+P + R G +I + D+G Y C+ N G E
Sbjct: 157 GHPEPTISWKKD--GSP--LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
Query: 1371 -ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG---YILQYSEDNSEQWGS 1426
+ L V P V + ++ ++T+ RG +++ +D+ E S
Sbjct: 213 EVAELTVLERPS----FVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 1427 FPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQF 1477
+ + ++ + G +T A+N VG S + + + P F
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Score = 35.0 bits (79), Expect = 0.74
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS---IFSN 1341
P RI+ + + L CKA G P+P ++W K G D RS + +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--GGERVETDKDDPRSHRMLLPS 85
Query: 1342 GS-FIIRTVKAE----DSGYYSCIANNNWG 1366
GS F +R V D G Y C+A N G
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 226 bits (577), Expect = 1e-58
Identities = 254/989 (25%), Positives = 413/989 (41%), Gaps = 102/989 (10%)
Query: 621 SGDLPITITWQKDGRPIPGSLGVTIDNIDFTSS-LRISNLSLMHN-GNYTCIARNEAAAV 678
+GD I W K G+ + I+ D + S LRI L + Y C+A N +
Sbjct: 48 TGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEI 107
Query: 679 EHQSQLIV----RVP---PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGV 731
++L V ++P P + P+ + + + C+A G P P I W
Sbjct: 108 SVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITW-------F 160
Query: 732 PQFQPIAL---NGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSK--SMYLTVK- 785
F P+ NGRI+ L +G+L I+ E D G Y C +N G S ++Y+ V+
Sbjct: 161 KDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRVRR 220
Query: 786 IPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEE 845
+P + P G ++C A G V+W + PE +G
Sbjct: 221 VPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPE------DDMPIGRN 274
Query: 846 VISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIEI-KDVKARTITLR 904
V+ L VR+ + + +C A+++ G I Q+TV+ P PP + + A +ITL
Sbjct: 275 VLE----LNDVRQSANY-TCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLT 329
Query: 905 WTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSA-TIIDIHPSSTYSIRMYAK 963
W G P++ Y I+ K K+ S + K++ + ++ + P S Y R+ A
Sbjct: 330 WDSG--NPEPVSYYIIQHKPKN----SEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAV 383
Query: 964 NRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIG 1023
N IG+ PS + E AP P++V +SS +I V WK P++ NG I+GY++
Sbjct: 384 NNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEE--PNGQIQGYRVY 441
Query: 1024 YREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTT 1083
Y T N DS++ T+ NL Y + V A G GP S +I T
Sbjct: 442 YTMDPTQ---HVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVIT 498
Query: 1084 LEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNI 1143
VP P N +A S SI +SW+ + + + ++Y DGE GE + I
Sbjct: 499 QTGVPGQPL-NFKAEPESETSILLSWTPPRSDTI----ANYELVY----KDGEHGEEQRI 549
Query: 1144 TTTQ-PSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG-PPAGVKAAAAS 1201
T S L GL+ + Y ++ A + G G + +I RT + P PP + + S
Sbjct: 550 TIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPS 609
Query: 1202 ASMVFVSWLPPL--KLNGIIRKYTVFCSHPYPTVISEFEAS-------PDSFSYRIPNLS 1252
++ + VSW PP K NGII +Y++ Y V E + D+ Y + L
Sbjct: 610 STSILVSWQPPPVEKQNGIITEYSI----KYTAVDGEDDKPHEILGIPSDTTKYLLEQLE 665
Query: 1253 RNRQYSVWVVAVTSAGRGNSSEIITV---EPLAKAPARILTF----SGTVTTPWMKDIVL 1305
+ +Y + V A T G G S + + E + P R + S +V W +
Sbjct: 666 KWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPV-- 723
Query: 1306 PCKAVGD-PSPAVKWMKDSNGTPS---------LVTIDGRRSIFSNGSFIIRTVKAEDSG 1355
P K G V +++ NG P L + II ++ E S
Sbjct: 724 PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSY 783
Query: 1356 YYSCIANNNWGS---DEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGY 1412
+ A G + L P +PRL ++ T ++ + W P + ++GY
Sbjct: 784 SLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGY 843
Query: 1413 ILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLG 1472
L++ + E + S E + ++ G Y F L+A+N VG G E+++ ++
Sbjct: 844 RLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKEISIP 901
Query: 1473 KEPQFSKEQELFASINT-TRVRLN----LIGWNDGGCPITSFTLEYRPFGTTVWTTAQR- 1526
+E Q L + T T V+L+ ++ +G IT +TL YR + Q
Sbjct: 902 EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYRDINIPLLPMEQLI 959
Query: 1527 TSLSKSYILYDLQEATWYELQMRVCNSAG 1555
+ L L+ T Y++++R S G
Sbjct: 960 VPADTTMTLTGLKPDTTYDVKVRAHTSKG 988
Score = 198 bits (503), Expect = 5e-50
Identities = 259/1057 (24%), Positives = 418/1057 (39%), Gaps = 130/1057 (12%)
Query: 504 PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGT---LK 560
P R + T ++G C+ G P I W K + +V ++G+ L+
Sbjct: 24 PRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLR 83
Query: 561 LSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVPPFIQPFEF-PRFSIGQRVFIP 616
+ ++ DE Y C N + + +ST +V ++P + P+ + +R
Sbjct: 84 IQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTA 143
Query: 617 CVV--VSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNE 674
++ SG+ ITW KD P+ S + +L+I G Y C+A N
Sbjct: 144 TMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNS 203
Query: 675 A----AAVEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAG 730
A +A + + RVPP+F + P + + + G +V + C A G P+P + W
Sbjct: 204 AGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDL 263
Query: 731 VPQ-FQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAM 789
P+ PI N VL + S Y C + +G + +TVK
Sbjct: 264 TPEDDMPIGRN----VLELNDV-------RQSANYTCVAMSTLGV-IEAIAQITVK---A 308
Query: 790 ITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPE-MARYLVSTK-EVGEEVI 847
+ P T + T+ ++ T W+ NPE ++ Y++ K + EE+
Sbjct: 309 LPKPPGTPVVTESTATSITLT----------WDSG----NPEPVSYYIIQHKPKNSEELY 354
Query: 848 STLQILPTVREDSGFFSCH--------AINSYGE---DRGIIQLTVQEPPD--PPEIEIK 894
+ + T R S + A+N+ G ++ T ++ P P +++ +
Sbjct: 355 KEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQAR 414
Query: 895 DVKARTITLRWTMGFDGNSPITGYDI----ECKNKSDSWDSAQRTKDVSPQLNSATIIDI 950
+ + TI ++W + N I GY + + ++W K TI ++
Sbjct: 415 MLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNW-----MKHNVADSQITTIGNL 469
Query: 951 HPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKK 1010
P TYS+++ A IG S+++ + P G P EP S SI ++W P+
Sbjct: 470 VPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSILLSWTPPR- 527
Query: 1011 HLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRA 1070
+ I Y++ Y++ G Q I TS Y L L + Y + A +
Sbjct: 528 ---SDTIANYELVYKD-GEHGEEQRITIEPGTS-----YRLQGLKPNSLYYFRLAARSPQ 578
Query: 1071 GTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWA 1130
G G S+ EI T++ PS PP+++ + S SI +SW E NGI+ + + Y A
Sbjct: 579 GLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638
Query: 1131 NLMDGE---LGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKED 1187
+DGE EI I + L+ LEK+T Y I V A T G G S + RT ED
Sbjct: 639 --VDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNED 696
Query: 1188 VP-GPPAGVKAAAASASMVFVSWLPPL--KLNGIIRKYTVFCSHPYPTVISEFEASP--- 1241
VP GPP V+ A +++ V VSW P+ K +G IR Y V H E + P
Sbjct: 697 VPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQV---HYVRMENGEPKGQPMLK 753
Query: 1242 --------------DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPAR 1287
I L YS+ V A T+ G G S+ V P +
Sbjct: 754 DVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK 813
Query: 1288 -ILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFII 1346
L + T + P G P + L T++ F
Sbjct: 814 PRLVINHTQMNTALIQWHPPVDTFG-PLQGYRLKFGRKDMEPLTTLEFSE---KEDHFTA 869
Query: 1347 RTVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQP-----RLTVSKTTSSSITLSWLP 1401
+ S + A N G E ++ ++ +P + P L TTS+S+ LSW P
Sbjct: 870 TDIHKGASYVFRLSARNKVGFGEEMVK-EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQP 928
Query: 1402 ---GDNGGSSIRGYILQYSEDN-----SEQWGSFPISPSERSYRLENLKCGTWYKFTLTA 1453
+ G I Y L Y + N EQ I P++ + L LK T Y + A
Sbjct: 929 PVLAERNG-IITKYTLLYRDINIPLLPMEQL----IVPADTTMTLTGLKPDTTYDVKVRA 983
Query: 1454 QNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTT 1490
GPG S ++ +TL + F+K + A + T+
Sbjct: 984 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTS 1020
Score = 156 bits (394), Expect = 2e-37
Identities = 226/933 (24%), Positives = 351/933 (37%), Gaps = 124/933 (13%)
Query: 689 PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLS- 747
PP+F P DQ G+ G C A G P P IVW KG V N R +V+
Sbjct: 23 PPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWN-KKGKKVS-------NQRFEVIEF 74
Query: 748 ---NGSLLIKHVVE--EDSGYYLCKVSNDVGADVSKSMYLTV----KIPA---MITSYPN 795
+GS+L + D Y C SN+VG ++S S LTV +IP I P
Sbjct: 75 DDGSGSVLRIQPLRTPRDEAIYECVASNNVG-EISVSTRLTVLREDQIPRGFPTIDMGPQ 133
Query: 796 TTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPT 855
+ + + M C A G + W K+ ++ + G LQI +
Sbjct: 134 LKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSG-----ALQIEQS 188
Query: 856 VREDSGFFSCHAINSYGEDRGI-IQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSP 914
D G + C A NS G L V+ PP I + G+
Sbjct: 189 EESDQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMP-------GGSVN 241
Query: 915 ITGYDIECKNKSDSWDSAQRTKDVSPQ------LNSATIIDIHPSSTYSIRMYAKNRIGK 968
IT + W +D++P+ N + D+ S+ Y+ A + +G
Sbjct: 242 ITCVAVGSPMPYVKWMLG--AEDLTPEDDMPIGRNVLELNDVRQSANYTC--VAMSTLGV 297
Query: 969 SEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYS 1028
E ++T+ +A P P V E ++ SI +TW + + Y I +
Sbjct: 298 IEAIAQITV---KALPKPPGTPVVTESTAT-SITLTWDSGNPEPVS-----YYIIQHKPK 348
Query: 1029 TGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVP 1088
I V T+ Y++ L+ ++ Y V A N G GP S+ ++T T E P
Sbjct: 349 NSEELYKEIDGVATTR----YSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAP 404
Query: 1089 SYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQP 1148
S P +VQA S +I + W E NG +QG+RV Y + +K+
Sbjct: 405 SSAPRDVQARMLSSTTILVQWK--EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 462
Query: 1149 SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVS 1208
+ L YS++VLAFT GDG S I T+ VPG P KA S + + +S
Sbjct: 463 ITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLS 522
Query: 1209 WLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAG 1268
W PP + I Y + P + SYR+ L N Y + A + G
Sbjct: 523 WTPP--RSDTIANYELVYKDGEHGEEQRITIEPGT-SYRLQGLKPNSLYYFRLAARSPQG 579
Query: 1269 RGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKW----MKDSN 1324
G S+ I+ + P+ P +DI C + S V W ++ N
Sbjct: 580 LGASTAEISARTMQSKPS---------APP--QDI--SCTSPSSTSILVSWQPPPVEKQN 626
Query: 1325 G-----TPSLVTIDGR----RSIFSNGS----FIIRTVKAEDSGYYSCIANNNWG----S 1367
G + +DG I S +++ ++ + A+ + G S
Sbjct: 627 GIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES 686
Query: 1368 DEIILNLQVQVPPDQPR-LTVSKTTSSSITLSW---LPGDNGGSSIRGYILQYSE-DNSE 1422
+++ VP PR + V S+S+ +SW +P G IRGY + Y +N E
Sbjct: 687 LSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHG-QIRGYQVHYVRMENGE 745
Query: 1423 QWGSFPI-------------SPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAK 1469
G + +E + L+ T Y T+TA G G S+
Sbjct: 746 PKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVS 805
Query: 1470 TLGKEPQFSKEQELFASINTTRVRLNLIGWN---DGGCPITSFTLEYRPFGTTVWTTAQR 1526
T G P + IN T++ LI W+ D P+ + L++ TT +
Sbjct: 806 TTGAVPGKPR-----LVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEF 860
Query: 1527 TSLSKSYILYDLQEATWYELQMRVCNSAGCAEK 1559
+ + D+ + Y ++ N G E+
Sbjct: 861 SEKEDHFTATDIHKGASYVFRLSARNKVGFGEE 893
Score = 142 bits (358), Expect = 3e-33
Identities = 242/1062 (22%), Positives = 395/1062 (37%), Gaps = 164/1062 (15%)
Query: 307 RLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGIN 366
R + P + T +P G S C TG ++ W + G+ ++ N R I
Sbjct: 17 RTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVS---NQRFEVIE 73
Query: 367 HEN------LIMDHMVKSDGGAYQCFVRKD--KLSAQDYVQVVLED----GTPKIISAFS 414
++ I D Y+C + ++S + V+ ED G P I
Sbjct: 74 FDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQ 133
Query: 415 EKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPI-LKGGSHRISQMITSEGNVVSYLNISS 473
KVV +++C G P P ITW D P+ + RI Q+ + L I
Sbjct: 134 LKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGA------LQIEQ 187
Query: 474 SQVRDGGVYRCTANNSAGVVLYQA------RINVRGPASIRPMKNITAIAGRDTYIHCRV 527
S+ D G Y C A NSAG Y A R+ P P N + G I C
Sbjct: 188 SEESDQGKYECVATNSAG-TRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVA 246
Query: 528 IGYPYYSIKWYKNS-NLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTS 586
+G P +KW + +L P + + L+L+DV++ + YTC + L
Sbjct: 247 VGSPMPYVKWMLGAEDLTPEDDMPI---GRNVLELNDVRQSAN---YTC--VAMSTLGVI 298
Query: 587 QSV-HVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGS----- 640
+++ +TVK P + P V S IT+TW G P P S
Sbjct: 299 EAIAQITVKALP-------------KPPGTPVVTESTATSITLTWD-SGNPEPVSYYIIQ 344
Query: 641 --------LGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKF 692
L ID + T+ ++ LS + + +A N ++ + +
Sbjct: 345 HKPKNSEELYKEIDGV-ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA 403
Query: 693 VVQ-PRD-QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQ------ 744
PRD Q + IL + WK +P NG+IQ
Sbjct: 404 PSSAPRDVQARMLSSTTIL-----------VQWK----------EPEEPNGQIQGYRVYY 442
Query: 745 ---VLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQ 801
+ + +KH V + +G V + Y +VK+ A TS + L++
Sbjct: 443 TMDPTQHVNNWMKHNVADSQ-------ITTIGNLVPQKTY-SVKVLA-FTSIGDGPLSSD 493
Query: 802 ----------GQKKEMSCTAHGEKPIIVRW--EKEDRIINPEMARYLVSTKEVGEEVIST 849
GQ E I++ W + D I N E+ + E GEE T
Sbjct: 494 IQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYEL---VYKDGEHGEEQRIT 550
Query: 850 LQILPTVR------EDSGFFSCHAINSYGEDRGIIQL---TVQEPPD--PPEIEIKDVKA 898
++ + R +F A + G ++ T+Q P P +I +
Sbjct: 551 IEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSS 610
Query: 899 RTITLRWTMG--FDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTY 956
+I + W N IT Y I+ D + + + + Y
Sbjct: 611 TSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY 670
Query: 957 SIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGI 1016
I + A +G S + I +E P GPP++V +E ++S S++V+W++P + Q+G
Sbjct: 671 RITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQ 730
Query: 1017 IRGYQIGYREYST----GGNFQFNIISVDTSGDSEVYT-----LDNLNKFTQYGLVVQAC 1067
IRGYQ+ Y G +++ D + + T + L T Y L V A
Sbjct: 731 IRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAY 790
Query: 1068 NRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVI 1127
G G S+ + +T VP P + T + I W G LQG+R+
Sbjct: 791 TTKGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWH--PPVDTFGPLQGYRLK 846
Query: 1128 YWANLMDGELGEIKNITTTQPSLELD-----GLEKYTNYSIQVLAFTRAGDGVRSEQIFT 1182
+ +++ +TT + S + D + K +Y ++ A + G G + +
Sbjct: 847 FGRK-------DMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEIS 899
Query: 1183 RTKEDVPGPPAGVKAAAASASMVFVSWLPPL--KLNGIIRKYT-VFCSHPYPTVISEFEA 1239
+E G P + + +++ V +SW PP+ + NGII KYT ++ P + E
Sbjct: 900 IPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLI 959
Query: 1240 SPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPL 1281
P + + L + Y V V A TS G G S + L
Sbjct: 960 VPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTL 1001
Score = 82.0 bits (201), Expect = 5e-15
Identities = 88/340 (25%), Positives = 143/340 (42%), Gaps = 22/340 (6%)
Query: 886 PDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSA 945
P P + I + T ++W D P+ GY ++ K T + S + +
Sbjct: 811 PGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDME---PLTTLEFSEKEDHF 867
Query: 946 TIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTW 1005
T DIH ++Y R+ A+N++G E + I+ E P G PQ +H E +S S++++W
Sbjct: 868 TATDIHKGASYVFRLSARNKVGFGEEMVK-EISIPEEVPTGFPQNLHSEGTTSTSVQLSW 926
Query: 1006 KAPKKHLQNGIIRGYQIGYREYSTG-GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVV 1064
+ P +NGII Y + YR+ + + I+ DT+ TL L T Y + V
Sbjct: 927 QPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTT-----MTLTGLKPDTTYDVKV 981
Query: 1065 QACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGF 1124
+A G GP S + TL V +N A S+ +SW E N + F
Sbjct: 982 RAHTSKGPGPYSPSVQFRTL-PVDQVFAKNFHVKAVMKTSVLLSWEI--PENYNSAMP-F 1037
Query: 1125 RVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRT 1184
+++Y DG++ E + TQ + L+ +YS VL G ++ +T
Sbjct: 1038 KILY----DDGKMVEEVDGRATQKLIV--NLKPEKSYSF-VLTNRGNSAGGLQHRVTAKT 1090
Query: 1185 KEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTV 1224
DV M+ V LP + N I+ Y +
Sbjct: 1091 APDVLRTKPAFIGKTNLDGMITVQ-LPEVPANENIKGYYI 1129
Score = 67.4 bits (163), Expect = 1e-10
Identities = 69/307 (22%), Positives = 121/307 (39%), Gaps = 34/307 (11%)
Query: 216 FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLK-----DNMPLELSGR 270
F+ A + P + ++G C+A G P P W K N E+
Sbjct: 15 FLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEF 74
Query: 271 FQKTVTGLLIENIR-PSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKS-SVG 328
+ + L I+ +R P D Y C SN G V RL V L+ PR + +G
Sbjct: 75 DDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTV---LREDQIPRGFPTIDMG 131
Query: 329 SQV---------SLSCSVTGTEDQELSWYRNG-EILNPGKNVRITGINHENLIMDHMVKS 378
Q+ ++ C+ +G D E++W+++ + N RI + L ++ +S
Sbjct: 132 PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEES 191
Query: 379 DGGAYQCFVRKD---KLSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPL 435
D G Y+C + SA + V + P+ + + P V++ C G+P+
Sbjct: 192 DQGKYECVATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPM 251
Query: 436 PTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLY 495
P + W L + + I + + + + VR Y C A ++ GV+
Sbjct: 252 PYVKWMLGAEDLTPEDDMPIGRNV-----------LELNDVRQSANYTCVAMSTLGVIEA 300
Query: 496 QARINVR 502
A+I V+
Sbjct: 301 IAQITVK 307
Score = 64.7 bits (156), Expect = 9e-10
Identities = 67/249 (26%), Positives = 98/249 (39%), Gaps = 25/249 (10%)
Query: 132 DQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLIT-----STGALYIKDV 186
DQ + G VA F C I W K VS RF + S L I+ +
Sbjct: 32 DQTGVSGGVASFICQATGDPRPKIV---WNKKGKK-VSNQRFEVIEFDDGSGSVLRIQPL 87
Query: 187 QNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVE-LP 245
+ Y C+ + GE S + D +D K + R +
Sbjct: 88 RTPRDEAIYECVASNN-VGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATML 146
Query: 246 CKALGHPEPDYRWLKDNMPLELS---GRFQKTVTGLL-IENIRPSDSGSYVCEVSNRYGT 301
C A G+P+P+ W KD +P++ S GR ++ +G L IE SD G Y C +N GT
Sbjct: 147 CAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECVATNSAGT 206
Query: 302 A-KVIGRLYV---KQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNP- 356
LYV + P + +I P + G V+++C G+ + W E L P
Sbjct: 207 RYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPE 266
Query: 357 -----GKNV 360
G+NV
Sbjct: 267 DDMPIGRNV 275
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 226 bits (577), Expect = 1e-58
Identities = 262/984 (26%), Positives = 402/984 (40%), Gaps = 146/984 (14%)
Query: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--------TLDDDPILKGGSHR 454
ED P+I+ S+ +VS EP +L C +G P PTI W T DDP SHR
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDP----RSHR 80
Query: 455 ISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRP 509
M+ G++ + + R D GVY C A N G V + A + V R P
Sbjct: 81 ---MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 510 MKNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568
+ A+ G + C+ G+P +I W K+ + L ++ G L ++ +K
Sbjct: 138 SDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKS- 194
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTV-KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
D G+Y C S+ +TV + P F++ ++ C +P T
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-T 253
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
+ W+KD +P S D+ +L+I ++ G+YTC+A N E + L V+
Sbjct: 254 VRWRKDDGELPKSRYEIRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Query: 688 V---PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP-QFQPIALNGRI 743
V PP FVV+PRDQ G+ V C A G P P I W+ + +QP + R
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 744 QVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV------KIPAMITSYP-NT 796
V G L I +V D GYY+C+ N G+ ++K+ YL V + P +I P N
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKA-YLEVTDVIADRPPPVIRQGPVNQ 428
Query: 797 TLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV 856
T+A G +SC A G + W K+ +++ + +R + E G LQI
Sbjct: 429 TVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENG-----VLQIRYAK 480
Query: 857 REDSGFFSCHAINSYGEDRGIIQLTVQE----------------PPDPPEIEIKDVKART 900
D+G ++C A GE + VQE P P + E+ DV T
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
Query: 901 ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRM 960
+TL W + + T Y IE + + S+ +T + + ++ I + P++ Y +
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLV 598
Query: 961 YAKNRIGKSEPSN-ELTITADEAAPDGPPQE------------VHLE---PISSQSIRVT 1004
A N G S+PS + + P + +HL +SS SI V
Sbjct: 599 RAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVH 658
Query: 1005 WKAPKKHLQNGIIRGYQIGYREYSTG-GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLV 1063
W + Q+ I+GY+I YR G + + V T + V + +L K Y +
Sbjct: 659 WTVDQ---QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIK 714
Query: 1064 VQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT--SPESISISWSTLSKEALNGIL 1121
+ G S+ TLE+ PS PP+ V + +I +SW ++ NG++
Sbjct: 715 ARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMV 774
Query: 1122 QGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIF 1181
Q ++V W + K + + S+ + L YS++V A T AG GV+SE F
Sbjct: 775 QEYKV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQF 832
Query: 1182 TRTKEDVPGPP-----------------------AGVKAAAASASMVFVSWL--PPLKLN 1216
+ D G P AG+ AA MVF WL K N
Sbjct: 833 IQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRN 890
Query: 1217 GI------IRKYTVFCSHPYPTV-----------------ISEFEASPDSFSYRIPNLSR 1253
G+ IRK F P T ISE A P + PN
Sbjct: 891 GLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQP-WLADTWPNTGN 949
Query: 1254 NRQYSVWVVAVTSAGRGNSSEIIT 1277
N ++ ++ +AG GNS +T
Sbjct: 950 N--HNDCSISCCTAGNGNSDSNLT 971
Score = 131 bits (330), Expect = 6e-30
Identities = 192/855 (22%), Positives = 339/855 (39%), Gaps = 106/855 (12%)
Query: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
P + P + S G +L+C G + WY+ GE + K+ +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQV-VLEDGTPKIISAFSEKVVSP 420
+ ++ + D G Y C R + +S ++V +L D S+ +V+
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVMVAV 144
Query: 421 AEPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
EP + C +G P PTI+W D P+ + IT G L I+ ++ D
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL-----DDKDERITIRG---GKLMITYTRKSDA 196
Query: 480 GVYRCTANNSAGVVLYQ-ARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKW 537
G Y C N G + A + V P+ ++ N+ C G P +++W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 538 YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVK 594
K+ LP + ++ ++ TLK+ V D G YTC N++ + + S + +V V +
Sbjct: 257 RKDDGELPKSRYEI--RDDHTLKIRKVTAG-DMGSYTCVAENMVGKAEASATLTVQVGSE 313
Query: 595 VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG--------RPIPGSLGVTID 646
P F+ ++G+ V C P I W+++G +P S ++
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 647 NIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQD 700
T L I+N+ G Y C N A ++ ++ L V R PP P +Q
Sbjct: 373 Q---TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 701 GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEED 760
+L+C A G PVPTI+W+ K + Q + RI+ L NG L I++ D
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWR--KDGVLVSTQ----DSRIKQLENGVLQIRYAKLGD 483
Query: 761 SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTT----LATQGQKKEMSCTAHGEKP 816
+G Y C S G + + S Y+ V+ + P T + + K E+ T
Sbjct: 484 TGRYTCIASTPSG-EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNT 540
Query: 817 IIVRWEKE--------DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-FSCHA 867
+ + W+ II S + V E V + + ++ ++ + F A
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
Query: 868 INSYG------------------EDRGIIQLTVQEPPDPPEIEIKD---VKARTITLRWT 906
N+YG +G+ VQ + + + + + +I + WT
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 907 MGFDGNSPITGYDIECK-NKSDSWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYA-K 963
+ + I GY I + + ++ +S +V +P NS I D+ Y I+
Sbjct: 661 VD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 964 NRIGKSEPSNELTITADEAAPDGPPQEVHLEPI--SSQSIRVTWKAPKKHLQNGIIRGYQ 1021
N ++ + T +E AP PPQ V + + +I V+W+ P + QNG+++ Y+
Sbjct: 720 NEFQGADSEIKFAKTLEE-APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYK 778
Query: 1022 IGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ-EII 1080
+ + G +++ I+ G + + L +Y + V A AG+G S+ + I
Sbjct: 779 V----WCLGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFI 833
Query: 1081 TTTLEDVPSYPPENV 1095
P P + V
Sbjct: 834 QLDAHGNPVSPEDQV 848
Score = 117 bits (293), Expect = 1e-25
Identities = 129/490 (26%), Positives = 194/490 (39%), Gaps = 65/490 (13%)
Query: 46 CPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPPSSFSTLIH----- 96
C A G P T+ WY GE + D R + P+G+L F ++H
Sbjct: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLPSGSL--------FFLRIVHGRKSR 100
Query: 97 --DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEA 153
+ Y C A N G+ S + ++ A+LR+ + D G AV +C P
Sbjct: 101 PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE 160
Query: 154 YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA 213
+SW+KD L + G L I + D Y C+ + GE R+S A
Sbjct: 161 --PTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTN-MVGE-RESEVA 215
Query: 214 RL-------FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
L FV P+N A ++ D E C+A G P P RW KD+ L
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDS-----------AEFKCEARGDPVPTVRWRKDDGELP 264
Query: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVK---QPLKATISPRKV 323
S + L I + D GSY C N G A+ L V+ +P + PR
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324
Query: 324 KSSVGSQVSLSCSVTGTEDQELSWYRNG------EILNPGKNVRITGINHENLIMDHMVK 377
++G V+ C TG + W R G P + R + +L + ++ +
Sbjct: 325 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 384
Query: 378 SDGGAYQCFVRK--DKLSAQDYVQV--VLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKG 432
SD G Y C + + Y++V V+ D P +I + V+ L C G
Sbjct: 385 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATG 444
Query: 433 TPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV 492
+P+PTI W D ++ RI Q+ E V L I +++ D G Y C A+ +G
Sbjct: 445 SPVPTILWR-KDGVLVSTQDSRIKQL---ENGV---LQIRYAKLGDTGRYTCIASTPSGE 497
Query: 493 VLYQARINVR 502
+ A I V+
Sbjct: 498 ATWSAYIEVQ 507
Score = 103 bits (258), Expect = 1e-21
Identities = 126/493 (25%), Positives = 188/493 (38%), Gaps = 46/493 (9%)
Query: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL---------IENIRPS--D 287
G+ L CKA G P P W K +E ++ LL I + R S D
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 288 SGSYVCEVSNRYGTAKVIGRLYVKQPLKATI--SPRKVKSSVGSQVSLSCS-VTGTEDQE 344
G YVC N G A L+ +P V +VG + C G +
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 345 LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLED 404
+SW ++G L+ K+ RIT I L++ + KSD G Y C + V +
Sbjct: 163 ISWKKDGSPLD-DKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
Query: 405 GTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN 464
P + S V+ + C +G P+PT+ W DD + K + I T
Sbjct: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDDHT---- 275
Query: 465 VVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS-----IRPMKNITAIAGR 519
L I D G Y C A N G A + V+ + ++P + A+ GR
Sbjct: 276 ----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVAL-GR 330
Query: 520 DTYIHCRVIGYPYYSIKWYK--NSNLL-----PFNHRQVAFENNGTLKLSDVQKEVDEGE 572
C G P +I W + + NLL P + + + G L +++VQ+ D G
Sbjct: 331 TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGY 389
Query: 573 YTCNVL-VQPQLSTSQSVHVTVKV----PPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
Y C L V + T + VT + PP I+ + F+ V +G T
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 449
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
I W+KDG + + I ++ L+I L G YTCIA + + + V+
Sbjct: 450 ILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Query: 688 VPPKFVVQPRDQD 700
V PR D
Sbjct: 508 EFGVPVQPPRPTD 520
Score = 97.8 bits (242), Expect = 9e-20
Identities = 120/465 (25%), Positives = 186/465 (40%), Gaps = 57/465 (12%)
Query: 172 RFLITSTGALYIKDVQN-----EDGLYNYRCITRHRYTGETRQSNSAR--LFVSDPANSA 224
R L+ S +++ V ++G+Y C+ R+ Y GE N++ + D
Sbjct: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYV--CVARN-YLGEAVSHNASLEVAILRDDFRQN 136
Query: 225 PSILDGFDHRKAMAGQRVELPCKA-LGHPEPDYRWLKDNMPLELSGRFQKTVTG--LLIE 281
PS + G+ + C+ GHPEP W KD PL+ + T+ G L+I
Sbjct: 137 PSDV------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMIT 189
Query: 282 NIRPSDSGSYVCEVSNRYGTAK-VIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGT 340
R SD+G YVC +N G + + L V + P + +V C G
Sbjct: 190 YTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD 249
Query: 341 EDQELSWYR-NGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQC----FVRKDKLSAQ 395
+ W + +GE+ +R + L + + D G+Y C V K + SA
Sbjct: 250 PVPTVRWRKDDGELPKSRYEIR----DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASAT 305
Query: 396 DYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPIL------K 449
VQV E P + ++VV+ V+ C G P P I W + L
Sbjct: 306 LTVQVGSE--PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
Query: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV------RG 503
S R S T + L I++ Q D G Y C N AG ++ +A + V R
Sbjct: 364 QSSSRFSVSQTGD------LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417
Query: 504 PASIR--PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL 561
P IR P+ A+ G + C G P +I W K+ L+ ++ NG L++
Sbjct: 418 PPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 476
Query: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPR 606
K D G YTC + P + S + ++V F P + PR
Sbjct: 477 R-YAKLGDTGRYTC-IASTPSGEATWSAY--IEVQEFGVPVQPPR 517
Score = 82.4 bits (202), Expect = 4e-15
Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 41/319 (12%)
Query: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
VL C A G P P + W KD + T D R NG IR K D+G Y+CIA+
Sbjct: 437 VLSCVATGSPVPTILWRKDG---VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 1364 NWGSDEIILNLQVQ---VPPDQPRLT-------------VSKTTSSSITLSWLPGDNGGS 1407
G ++VQ VP PR T V+ + +++TLSW P N G+
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
Query: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
+ YI++ +S + W + + + ++ LK Y F + A N G P +IS
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 613
Query: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGW--NDGGCPITSFTL 1511
+ ++ + + Q +++ + + L+ + W + I + +
Sbjct: 614 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 673
Query: 1512 EYRP----FGTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR-VCNSAGCAEKQANFAT 1565
YRP G + W + RT S ++ DL++ YE++ R N A+ + FA
Sbjct: 674 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
Query: 1566 LNYDGSTIPPLIKSVVQNE 1584
+ + PP +V +N+
Sbjct: 734 TLEEAPSAPPQGVTVSKND 752
Score = 53.9 bits (128), Expect = 2e-06
Identities = 31/81 (38%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C+A GDP P V+W KD P R I + + IR V A D G Y+C+A N G
Sbjct: 244 CEARGDPVPTVRWRKDDGELPK-----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 1367 SDEIILNLQVQVPPDQPRLTV 1387
E L VQV + P V
Sbjct: 299 KAEASATLTVQVGSEPPHFVV 319
Score = 47.8 bits (112), Expect = 1e-04
Identities = 79/383 (20%), Positives = 144/383 (37%), Gaps = 57/383 (14%)
Query: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMK 1301
D + +I ++ S VA G+ +S +TV+ ++ P ++ V +
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALG-R 330
Query: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKAEDSG 1355
+ C+A G+P PA+ W ++ G+ +L+ R S+ G I V+ D G
Sbjct: 331 TVTFQCEATGNPQPAIFWRRE--GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 388
Query: 1356 YYSCIANNNWGSDEIILNLQV-QVPPDQPRLTVSK-TTSSSITLSWLPGDNGGSSIRGYI 1413
YY C N GS L+V V D+P + + + ++ + G+ + +
Sbjct: 389 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD-------GTFVLSCV 441
Query: 1414 LQYSEDNSEQWGSFPISPSERSYRLENL----------KCGTWYKFTLTAQNGVGPGRIS 1463
S + W + S + R++ L K G ++T A G S
Sbjct: 442 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501
Query: 1464 EIIEAKTLG--KEPQFSKEQELFASI----NTTRVRLNLI--GW----NDGGCPITSFTL 1511
IE + G +P + L S T V N + W N G P TS+ +
Sbjct: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-TSYII 560
Query: 1512 E-YRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDG 1570
E + + W T +++ + L+ Y +R N+ G ++
Sbjct: 561 EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD------------ 608
Query: 1571 STIPPLIKSVVQNEEGLTTNEGL 1593
P I V+ ++ L T++G+
Sbjct: 609 ---PSQISDPVKTQDVLPTSQGV 628
Score = 35.8 bits (81), Expect = 0.43
Identities = 37/171 (21%), Positives = 66/171 (38%), Gaps = 14/171 (8%)
Query: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
G P P + W KD G+P + R G +I + D+G Y C+ N G E
Sbjct: 157 GHPEPTISWKKD--GSP--LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
Query: 1371 -ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG---YILQYSEDNSEQWGS 1426
+ L V P V + ++ ++T+ RG +++ +D+ E S
Sbjct: 213 EVAELTVLERPS----FVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 1427 FPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQF 1477
+ + ++ + G +T A+N VG S + + + P F
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Score = 35.0 bits (79), Expect = 0.74
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS---IFSN 1341
P RI+ + + L CKA G P+P ++W K G D RS + +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--GGERVETDKDDPRSHRMLLPS 85
Query: 1342 GS-FIIRTVKAE----DSGYYSCIANNNWG 1366
GS F +R V D G Y C+A N G
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 226 bits (577), Expect = 1e-58
Identities = 262/984 (26%), Positives = 402/984 (40%), Gaps = 146/984 (14%)
Query: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--------TLDDDPILKGGSHR 454
ED P+I+ S+ +VS EP +L C +G P PTI W T DDP SHR
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDP----RSHR 80
Query: 455 ISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRP 509
M+ G++ + + R D GVY C A N G V + A + V R P
Sbjct: 81 ---MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 510 MKNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568
+ A+ G + C+ G+P +I W K+ + L ++ G L ++ +K
Sbjct: 138 SDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKS- 194
Query: 569 DEGEYTCNVLVQPQLSTSQSVHVTV-KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
D G+Y C S+ +TV + P F++ ++ C +P T
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-T 253
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
+ W+KD +P S D+ +L+I ++ G+YTC+A N E + L V+
Sbjct: 254 VRWRKDDGELPKSRYEIRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
Query: 688 V---PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP-QFQPIALNGRI 743
V PP FVV+PRDQ G+ V C A G P P I W+ + +QP + R
Sbjct: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
Query: 744 QVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV------KIPAMITSYP-NT 796
V G L I +V D GYY+C+ N G+ ++K+ YL V + P +I P N
Sbjct: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKA-YLEVTDVIADRPPPVIRQGPVNQ 428
Query: 797 TLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV 856
T+A G +SC A G + W K+ +++ + +R + E G LQI
Sbjct: 429 TVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENG-----VLQIRYAK 480
Query: 857 REDSGFFSCHAINSYGEDRGIIQLTVQE----------------PPDPPEIEIKDVKART 900
D+G ++C A GE + VQE P P + E+ DV T
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
Query: 901 ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRM 960
+TL W + + T Y IE + + S+ +T + + ++ I + P++ Y +
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLV 598
Query: 961 YAKNRIGKSEPSN-ELTITADEAAPDGPPQE------------VHLE---PISSQSIRVT 1004
A N G S+PS + + P + +HL +SS SI V
Sbjct: 599 RAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVH 658
Query: 1005 WKAPKKHLQNGIIRGYQIGYREYSTG-GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLV 1063
W + Q+ I+GY+I YR G + + V T + V + +L K Y +
Sbjct: 659 WTVDQ---QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIK 714
Query: 1064 VQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT--SPESISISWSTLSKEALNGIL 1121
+ G S+ TLE+ PS PP+ V + +I +SW ++ NG++
Sbjct: 715 ARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMV 774
Query: 1122 QGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIF 1181
Q ++V W + K + + S+ + L YS++V A T AG GV+SE F
Sbjct: 775 QEYKV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQF 832
Query: 1182 TRTKEDVPGPP-----------------------AGVKAAAASASMVFVSWL--PPLKLN 1216
+ D G P AG+ AA MVF WL K N
Sbjct: 833 IQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRN 890
Query: 1217 GI------IRKYTVFCSHPYPTV-----------------ISEFEASPDSFSYRIPNLSR 1253
G+ IRK F P T ISE A P + PN
Sbjct: 891 GLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQP-WLADTWPNTGN 949
Query: 1254 NRQYSVWVVAVTSAGRGNSSEIIT 1277
N ++ ++ +AG GNS +T
Sbjct: 950 N--HNDCSISCCTAGNGNSDSNLT 971
Score = 131 bits (330), Expect = 6e-30
Identities = 192/855 (22%), Positives = 339/855 (39%), Gaps = 106/855 (12%)
Query: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
P + P + S G +L+C G + WY+ GE + K+ +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
Query: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQV-VLEDGTPKIISAFSEKVVSP 420
+ ++ + D G Y C R + +S ++V +L D S+ +V+
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVMVAV 144
Query: 421 AEPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
EP + C +G P PTI+W D P+ + IT G L I+ ++ D
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL-----DDKDERITIRG---GKLMITYTRKSDA 196
Query: 480 GVYRCTANNSAGVVLYQ-ARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKW 537
G Y C N G + A + V P+ ++ N+ C G P +++W
Sbjct: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
Query: 538 YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVK 594
K+ LP + ++ ++ TLK+ V D G YTC N++ + + S + +V V +
Sbjct: 257 RKDDGELPKSRYEI--RDDHTLKIRKVTAG-DMGSYTCVAENMVGKAEASATLTVQVGSE 313
Query: 595 VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG--------RPIPGSLGVTID 646
P F+ ++G+ V C P I W+++G +P S ++
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 647 NIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQD 700
T L I+N+ G Y C N A ++ ++ L V R PP P +Q
Sbjct: 373 Q---TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
Query: 701 GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEED 760
+L+C A G PVPTI+W+ K + Q + RI+ L NG L I++ D
Sbjct: 430 VAVDGTFVLSCVATGSPVPTILWR--KDGVLVSTQ----DSRIKQLENGVLQIRYAKLGD 483
Query: 761 SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTT----LATQGQKKEMSCTAHGEKP 816
+G Y C S G + + S Y+ V+ + P T + + K E+ T
Sbjct: 484 TGRYTCIASTPSG-EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNT 540
Query: 817 IIVRWEKE--------DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-FSCHA 867
+ + W+ II S + V E V + + ++ ++ + F A
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
Query: 868 INSYG------------------EDRGIIQLTVQEPPDPPEIEIKD---VKARTITLRWT 906
N+YG +G+ VQ + + + + + +I + WT
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 907 MGFDGNSPITGYDIECK-NKSDSWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYA-K 963
+ + I GY I + + ++ +S +V +P NS I D+ Y I+
Sbjct: 661 VD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
Query: 964 NRIGKSEPSNELTITADEAAPDGPPQEVHLEPI--SSQSIRVTWKAPKKHLQNGIIRGYQ 1021
N ++ + T +E AP PPQ V + + +I V+W+ P + QNG+++ Y+
Sbjct: 720 NEFQGADSEIKFAKTLEE-APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYK 778
Query: 1022 IGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ-EII 1080
+ + G +++ I+ G + + L +Y + V A AG+G S+ + I
Sbjct: 779 V----WCLGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFI 833
Query: 1081 TTTLEDVPSYPPENV 1095
P P + V
Sbjct: 834 QLDAHGNPVSPEDQV 848
Score = 117 bits (293), Expect = 1e-25
Identities = 129/490 (26%), Positives = 194/490 (39%), Gaps = 65/490 (13%)
Query: 46 CPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPPSSFSTLIH----- 96
C A G P T+ WY GE + D R + P+G+L F ++H
Sbjct: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLPSGSL--------FFLRIVHGRKSR 100
Query: 97 --DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEA 153
+ Y C A N G+ S + ++ A+LR+ + D G AV +C P
Sbjct: 101 PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE 160
Query: 154 YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA 213
+SW+KD L + G L I + D Y C+ + GE R+S A
Sbjct: 161 --PTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTN-MVGE-RESEVA 215
Query: 214 RL-------FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
L FV P+N A ++ D E C+A G P P RW KD+ L
Sbjct: 216 ELTVLERPSFVKRPSNLAVTVDDS-----------AEFKCEARGDPVPTVRWRKDDGELP 264
Query: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVK---QPLKATISPRKV 323
S + L I + D GSY C N G A+ L V+ +P + PR
Sbjct: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324
Query: 324 KSSVGSQVSLSCSVTGTEDQELSWYRNG------EILNPGKNVRITGINHENLIMDHMVK 377
++G V+ C TG + W R G P + R + +L + ++ +
Sbjct: 325 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 384
Query: 378 SDGGAYQCFVRK--DKLSAQDYVQV--VLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKG 432
SD G Y C + + Y++V V+ D P +I + V+ L C G
Sbjct: 385 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATG 444
Query: 433 TPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV 492
+P+PTI W D ++ RI Q+ E V L I +++ D G Y C A+ +G
Sbjct: 445 SPVPTILWR-KDGVLVSTQDSRIKQL---ENGV---LQIRYAKLGDTGRYTCIASTPSGE 497
Query: 493 VLYQARINVR 502
+ A I V+
Sbjct: 498 ATWSAYIEVQ 507
Score = 103 bits (258), Expect = 1e-21
Identities = 126/493 (25%), Positives = 188/493 (38%), Gaps = 46/493 (9%)
Query: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL---------IENIRPS--D 287
G+ L CKA G P P W K +E ++ LL I + R S D
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 288 SGSYVCEVSNRYGTAKVIGRLYVKQPLKATI--SPRKVKSSVGSQVSLSCS-VTGTEDQE 344
G YVC N G A L+ +P V +VG + C G +
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 345 LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLED 404
+SW ++G L+ K+ RIT I L++ + KSD G Y C + V +
Sbjct: 163 ISWKKDGSPLD-DKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
Query: 405 GTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN 464
P + S V+ + C +G P+PT+ W DD + K + I T
Sbjct: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDDHT---- 275
Query: 465 VVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS-----IRPMKNITAIAGR 519
L I D G Y C A N G A + V+ + ++P + A+ GR
Sbjct: 276 ----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVAL-GR 330
Query: 520 DTYIHCRVIGYPYYSIKWYK--NSNLL-----PFNHRQVAFENNGTLKLSDVQKEVDEGE 572
C G P +I W + + NLL P + + + G L +++VQ+ D G
Sbjct: 331 TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGY 389
Query: 573 YTCNVL-VQPQLSTSQSVHVTVKV----PPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
Y C L V + T + VT + PP I+ + F+ V +G T
Sbjct: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 449
Query: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
I W+KDG + + I ++ L+I L G YTCIA + + + V+
Sbjct: 450 ILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
Query: 688 VPPKFVVQPRDQD 700
V PR D
Sbjct: 508 EFGVPVQPPRPTD 520
Score = 97.8 bits (242), Expect = 9e-20
Identities = 120/465 (25%), Positives = 186/465 (40%), Gaps = 57/465 (12%)
Query: 172 RFLITSTGALYIKDVQN-----EDGLYNYRCITRHRYTGETRQSNSAR--LFVSDPANSA 224
R L+ S +++ V ++G+Y C+ R+ Y GE N++ + D
Sbjct: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYV--CVARN-YLGEAVSHNASLEVAILRDDFRQN 136
Query: 225 PSILDGFDHRKAMAGQRVELPCKA-LGHPEPDYRWLKDNMPLELSGRFQKTVTG--LLIE 281
PS + G+ + C+ GHPEP W KD PL+ + T+ G L+I
Sbjct: 137 PSDV------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMIT 189
Query: 282 NIRPSDSGSYVCEVSNRYGTAK-VIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGT 340
R SD+G YVC +N G + + L V + P + +V C G
Sbjct: 190 YTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD 249
Query: 341 EDQELSWYR-NGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQC----FVRKDKLSAQ 395
+ W + +GE+ +R + L + + D G+Y C V K + SA
Sbjct: 250 PVPTVRWRKDDGELPKSRYEIR----DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASAT 305
Query: 396 DYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPIL------K 449
VQV E P + ++VV+ V+ C G P P I W + L
Sbjct: 306 LTVQVGSE--PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
Query: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV------RG 503
S R S T + L I++ Q D G Y C N AG ++ +A + V R
Sbjct: 364 QSSSRFSVSQTGD------LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417
Query: 504 PASIR--PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL 561
P IR P+ A+ G + C G P +I W K+ L+ ++ NG L++
Sbjct: 418 PPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 476
Query: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPR 606
K D G YTC + P + S + ++V F P + PR
Sbjct: 477 R-YAKLGDTGRYTC-IASTPSGEATWSAY--IEVQEFGVPVQPPR 517
Score = 82.4 bits (202), Expect = 4e-15
Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 41/319 (12%)
Query: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
VL C A G P P + W KD + T D R NG IR K D+G Y+CIA+
Sbjct: 437 VLSCVATGSPVPTILWRKDG---VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
Query: 1364 NWGSDEIILNLQVQ---VPPDQPRLT-------------VSKTTSSSITLSWLPGDNGGS 1407
G ++VQ VP PR T V+ + +++TLSW P N G+
Sbjct: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
Query: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
+ YI++ +S + W + + + ++ LK Y F + A N G P +IS
Sbjct: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 613
Query: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGW--NDGGCPITSFTL 1511
+ ++ + + Q +++ + + L+ + W + I + +
Sbjct: 614 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 673
Query: 1512 EYRP----FGTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR-VCNSAGCAEKQANFAT 1565
YRP G + W + RT S ++ DL++ YE++ R N A+ + FA
Sbjct: 674 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
Query: 1566 LNYDGSTIPPLIKSVVQNE 1584
+ + PP +V +N+
Sbjct: 734 TLEEAPSAPPQGVTVSKND 752
Score = 53.9 bits (128), Expect = 2e-06
Identities = 31/81 (38%), Positives = 38/81 (46%), Gaps = 5/81 (6%)
Query: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
C+A GDP P V+W KD P R I + + IR V A D G Y+C+A N G
Sbjct: 244 CEARGDPVPTVRWRKDDGELPK-----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 1367 SDEIILNLQVQVPPDQPRLTV 1387
E L VQV + P V
Sbjct: 299 KAEASATLTVQVGSEPPHFVV 319
Score = 47.8 bits (112), Expect = 1e-04
Identities = 79/383 (20%), Positives = 144/383 (37%), Gaps = 57/383 (14%)
Query: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMK 1301
D + +I ++ S VA G+ +S +TV+ ++ P ++ V +
Sbjct: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALG-R 330
Query: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKAEDSG 1355
+ C+A G+P PA+ W ++ G+ +L+ R S+ G I V+ D G
Sbjct: 331 TVTFQCEATGNPQPAIFWRRE--GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 388
Query: 1356 YYSCIANNNWGSDEIILNLQV-QVPPDQPRLTVSK-TTSSSITLSWLPGDNGGSSIRGYI 1413
YY C N GS L+V V D+P + + + ++ + G+ + +
Sbjct: 389 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD-------GTFVLSCV 441
Query: 1414 LQYSEDNSEQWGSFPISPSERSYRLENL----------KCGTWYKFTLTAQNGVGPGRIS 1463
S + W + S + R++ L K G ++T A G S
Sbjct: 442 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501
Query: 1464 EIIEAKTLG--KEPQFSKEQELFASI----NTTRVRLNLI--GW----NDGGCPITSFTL 1511
IE + G +P + L S T V N + W N G P TS+ +
Sbjct: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-TSYII 560
Query: 1512 E-YRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDG 1570
E + + W T +++ + L+ Y +R N+ G ++
Sbjct: 561 EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD------------ 608
Query: 1571 STIPPLIKSVVQNEEGLTTNEGL 1593
P I V+ ++ L T++G+
Sbjct: 609 ---PSQISDPVKTQDVLPTSQGV 628
Score = 35.8 bits (81), Expect = 0.43
Identities = 37/171 (21%), Positives = 66/171 (38%), Gaps = 14/171 (8%)
Query: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
G P P + W KD G+P + R G +I + D+G Y C+ N G E
Sbjct: 157 GHPEPTISWKKD--GSP--LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
Query: 1371 -ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG---YILQYSEDNSEQWGS 1426
+ L V P V + ++ ++T+ RG +++ +D+ E S
Sbjct: 213 EVAELTVLERPS----FVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRKDDGELPKS 266
Query: 1427 FPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQF 1477
+ + ++ + G +T A+N VG S + + + P F
Sbjct: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Score = 35.0 bits (79), Expect = 0.74
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS---IFSN 1341
P RI+ + + L CKA G P+P ++W K G D RS + +
Sbjct: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--GGERVETDKDDPRSHRMLLPS 85
Query: 1342 GS-FIIRTVKAE----DSGYYSCIANNNWG 1366
GS F +R V D G Y C+A N G
Sbjct: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]
Length = 1018
Score = 225 bits (574), Expect = 3e-58
Identities = 234/944 (24%), Positives = 392/944 (41%), Gaps = 92/944 (9%)
Query: 303 KVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSW-YRNGEILNPGKNVR 361
K G ++ +QP+ TI P + S+ +VSL+C + W NG++
Sbjct: 37 KGFGPIFEEQPIN-TIYPEE---SLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYS 92
Query: 362 ITGINHENLIMDHMVKS-DGGAYQCFVRKDKLSAQDYVQVVLEDGT-------PKIISAF 413
+ G NL++++ K D G Y C L++ +Y V + T P
Sbjct: 93 MVG---GNLVINNPDKQKDAGIYYC------LASNNYGMVRSTEATLSFGYLDPFPPEER 143
Query: 414 SEKVVSPAEPVSLMCNVKGTPLPTIT--WTLDDDPILKGGSHR--ISQMITSEGNVVSYL 469
E V + + L+C+ ++ W L++ P+ R +SQ + GN L
Sbjct: 144 PEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQ---TNGN----L 196
Query: 470 NISSSQVRDGGVYRCTANNSA----------GVVLYQARINVRGPASIR-PMKNITAIAG 518
I++ + D G Y C ++ + ++ R PA I K++ A+ G
Sbjct: 197 YIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMG 256
Query: 519 RDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVL 578
++ + C +G P I+W K L P + LK+ ++Q E DEG Y C
Sbjct: 257 QNVTLECFALGNPVPDIRWRKV--LEPMPSTAEISTSGAVLKIFNIQLE-DEGIYECEAE 313
Query: 579 VQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIP 638
Q+ P +++ IG ++ PCV +P TI W K+G
Sbjct: 314 NIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIP-TIRWLKNGYAY- 371
Query: 639 GSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPR 697
LR+ +++ + G Y CIA N A+ ++L I+ + P F + P
Sbjct: 372 -----------HKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPM 420
Query: 698 DQDGIYGKA--VILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKH 755
+ + K VI+ C + P P W SKG + + + RI + +GSL I +
Sbjct: 421 KKKILAAKGGRVIIECKPKAAPKPKFSW--SKGT-----EWLVNSSRILIWEDGSLEINN 473
Query: 756 VVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEK 815
+ D G Y C N+ G S L + P I P T G+ M C A +
Sbjct: 474 ITRNDGGIYTCFAENNRGKANSTGT-LVITDPTRIILAPINADITVGENATMQCAASFDP 532
Query: 816 PIIVR--WEKEDRII--NPEMARYLVS--TKEVGEEVISTLQILPTVREDSGFFSCHAIN 869
+ + W +I N E Y + GE +I Q+ + +G ++C A
Sbjct: 533 ALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQL-----KHAGRYTCTAQT 587
Query: 870 SYGEDRGIIQLTVQEPPDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDIECKN-KSD 927
L V+ PP PP + I+D++A ++ L W+ G D +SPI+ Y I+ K SD
Sbjct: 588 IVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSD 647
Query: 928 SWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELT-ITADEAAPD 985
W A+ + + +A +D+ P Y R+ A N +G+ EPS I D AAP+
Sbjct: 648 DWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPN 707
Query: 986 GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGD 1045
P +V ++ + +TW + G GY + ++ + + + + DT
Sbjct: 708 VAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTG-- 765
Query: 1046 SEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESI 1105
V+ + ++ T + + V+A N G GP S + + +D PS P V S I
Sbjct: 766 RYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEI 825
Query: 1106 SISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQV 1165
S+ W + L I++ +++ YWA E +T+ + S L+ L T Y I+V
Sbjct: 826 SVHW----EHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEV 881
Query: 1166 LAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSW 1209
A AG G S+ I TK+ P P + ++ S S ++W
Sbjct: 882 GACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITW 925
Score = 187 bits (476), Expect = 7e-47
Identities = 238/994 (23%), Positives = 388/994 (39%), Gaps = 120/994 (12%)
Query: 241 RVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIEN--IRPSDSGSYVCEVSNR 298
+V L C+A P P Y+W +N ++L+ V G L+ N + D+G Y C SN
Sbjct: 60 KVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNN 119
Query: 299 YG----TAKVIGRLYVKQPLKATISPR-KVKSSVGSQVSLSCSVTGTEDQELSWYRNG-E 352
YG T + Y+ P P +VK G + +D W N
Sbjct: 120 YGMVRSTEATLSFGYL-DPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFP 178
Query: 353 ILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVV----LEDGTPK 408
+ R + NL + ++ SD G Y CFV ++ + + + + + T K
Sbjct: 179 VFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTK 238
Query: 409 -----IISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEG 463
I+ F + + V+L C G P+P I W +P+ + I++ G
Sbjct: 239 PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS------TAEISTSG 292
Query: 464 NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNITAIAGRDTY 522
V+ NI Q+ D G+Y C A N G +QARI V+ P + + + G D Y
Sbjct: 293 AVLKIFNI---QLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLY 349
Query: 523 IHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQ 582
C G P +I+W KN + G L+L DV E + G Y C +
Sbjct: 350 WPCVATGKPIPTIRWLKNGYAY----------HKGELRLYDVTFE-NAGMYQC---IAEN 395
Query: 583 LSTSQSVHVTVKVPPFIQPFEFPRF------SIGQRVFIPCVVVSGDLPITITWQKDGRP 636
+ + +K+ FE + G RV I C + P +W K
Sbjct: 396 TYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKP-KFSWSKGTEW 454
Query: 637 IPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQP 696
+ S + I SL I+N++ G YTC A N L++ P + ++ P
Sbjct: 455 LVNSSRILIWE---DGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 511
Query: 697 RDQDGIYGKAVILNCSAEGYPV--PTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIK 754
+ D G+ + C+A P T VW F+ + I + SNG LLI+
Sbjct: 512 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 571
Query: 755 HVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGE 814
+ + +G Y C V + S S L V+ P G +
Sbjct: 572 NAQLKHAGRYTCTAQTIVD-NSSASADLVVRGP-------------PGPPGGLRIEDIRA 617
Query: 815 KPIIVRWEKEDRIINPEMARYLVSTK-----------------EVGEEVISTLQILPTVR 857
+ + W + +P +++Y + TK E E + ++P +
Sbjct: 618 TSVALTWSRGSDNHSP-ISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWME 676
Query: 858 EDSGFFSCHAINSYGE-DRGIIQLTVQEPPDPPEIEIKDV-----KARTITLRWT----M 907
+ F A N+ G + I ++ P + DV + R +T+ W
Sbjct: 677 YE---FRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSRE 733
Query: 908 GFDGNSPITGYDIECKN-KSDSWDSAQRTKDVSPQLNSATIID--IHPSSTYSIRMYAKN 964
GN+ GY + K + W T +P D + PS+ + +++ A N
Sbjct: 734 YHYGNN--FGYIVAFKPFDGEEWKKVTVT---NPDTGRYVHKDETMSPSTAFQVKVKAFN 788
Query: 965 RIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGY 1024
G S I + + AP P EV ++ +SS I V W +H+ I+ YQI
Sbjct: 789 NKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHW----EHVLEKIVESYQI-- 842
Query: 1025 REYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTL 1084
Y + + V + L+NL TQY + V ACN AG GP S I T
Sbjct: 843 -RYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTK 901
Query: 1085 EDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNIT 1144
+ PS PP + ++ + I I+W + + + G++V+Y DG+ + K +
Sbjct: 902 KAPPSQPPRIISSVRSGSRYI-ITWDHVVALSNESTVTGYKVLY---RPDGQ-HDGKLYS 956
Query: 1145 TTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSE 1178
T + S+E+ + + Y ++V A + GDGV S+
Sbjct: 957 THKHSIEVP-IPRDGEYVVEVRAHSDGGDGVVSQ 989
Score = 158 bits (399), Expect = 6e-38
Identities = 216/918 (23%), Positives = 358/918 (38%), Gaps = 116/918 (12%)
Query: 424 VSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYR 483
VSL C + +P P W +++ + S R S + GN+V +N Q +D G+Y
Sbjct: 61 VSLNCRARASPFPVYKWRMNNGDV-DLTSDRYSMV---GGNLV--INNPDKQ-KDAGIYY 113
Query: 484 CTANNSAGVVLYQARINVRG-----PASIRPMKNITAIAGRDTYIHCRVIGYPYY----- 533
C A+N+ G+V G P RP + G+ + C PY+
Sbjct: 114 CLASNNYGMVRSTEATLSFGYLDPFPPEERP--EVRVKEGKGMVLLCDP---PYHFPDDL 168
Query: 534 SIKWYKNSN--LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHV 591
S +W N + + R+ + NG L +++V+ D+G Y+C V P ++ S
Sbjct: 169 SYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEAS-DKGNYSCFVS-SPSITKSVFSKF 226
Query: 592 TVKVP-----------PFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGS 640
+P + F+ +GQ V + C + +P I W+K P+P +
Sbjct: 227 IPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVP-DIRWRKVLEPMPST 285
Query: 641 LGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQD 700
++ + L+I N+ L G Y C A N +HQ+++ V+ P++V D +
Sbjct: 286 AEISTSG----AVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTE 341
Query: 701 GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEED 760
G + C A G P+PTI W NG G L + V E+
Sbjct: 342 VDIGSDLYWPCVATGKPIPTIRW--------------LKNG--YAYHKGELRLYDVTFEN 385
Query: 761 SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSY-----PNTTLATQGQKKEMSCTAHGEK 815
+G Y C N GA + + +KI A+ ++ LA +G + + C
Sbjct: 386 AGMYQCIAENTYGAIYANA---ELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAP 442
Query: 816 PIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDR 875
W K +LV++ + +L+I R D G ++C A N+ G+
Sbjct: 443 KPKFSWSKG--------TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKAN 494
Query: 876 GIIQLTVQEPPDPPEIEIKDVKA-----RTITLRWTMGFDGNSPIT------GYDIECKN 924
L + DP I + + A T++ FD +T GY I+ N
Sbjct: 495 STGTLVI---TDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF-N 550
Query: 925 KSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAP 984
K + D + +L I + A+ + S S +L + P
Sbjct: 551 KENIHYQRNFMLDSNGEL---LIRNAQLKHAGRYTCTAQTIVDNSSASADLVV----RGP 603
Query: 985 DGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSG 1044
GPP + +E I + S+ +TW + + I Y I + + G
Sbjct: 604 PGPPGGLRIEDIRATSVALTWSRGSDN--HSPISKYTIQTKTILSDDWKDAKTDPPIIEG 661
Query: 1045 DSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQAIATSPE 1103
+ E +L + +Y V A N G G PS T P+ P +V
Sbjct: 662 NMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNR 721
Query: 1104 SISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSL-----ELDGLEKY 1158
++I+W+ LS+E G G+ V + DGE E K +T T P + + +
Sbjct: 722 ELTITWAPLSREYHYGNNFGYIVAF--KPFDGE--EWKKVTVTNPDTGRYVHKDETMSPS 777
Query: 1159 TNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG-PPAGVKAAAASASMVFVSWLPPLKLNG 1217
T + ++V AF GDG S + +D P P V S+S + V W L
Sbjct: 778 TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHW--EHVLEK 835
Query: 1218 IIRKYTV--FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI 1275
I+ Y + + +H + + + +S R+ NL + QY + V A SAG G S++
Sbjct: 836 IVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDM 895
Query: 1276 I---TVEPLAKAPARILT 1290
I T + P RI++
Sbjct: 896 IEAFTKKAPPSQPPRIIS 913
Score = 118 bits (295), Expect = 7e-26
Identities = 140/576 (24%), Positives = 224/576 (38%), Gaps = 60/576 (10%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAE 105
C A P +W + G+ D+ R+ G L I ++ YYC A
Sbjct: 65 CRARASPFPVYKWRMNNGD--VDLTSDRYSMVGGNLVI-----NNPDKQKDAGIYYCLAS 117
Query: 106 NPSGKIRSQDVHIKAVLREPYT------VRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
N G +RS + + +P+ VRV++ K M V C P ++
Sbjct: 118 NNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGM-----VLLCDPPYHFPDDLSY-R 171
Query: 160 W---EKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLF 216
W E + RF+ + G LYI +V+ D NY C ++ S L
Sbjct: 172 WLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDK-GNYSCFVSSPSITKSVFSKFIPLI 230
Query: 217 VSDPANSAP---SILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQK 273
+ P I+ F A+ GQ V L C ALG+P PD RW K P+ +
Sbjct: 231 PIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEIST 290
Query: 274 TVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSL 333
+ L I NI+ D G Y CE N G K R+YV+ + + +GS +
Sbjct: 291 SGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYW 350
Query: 334 SCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK--DK 391
C TG + W +NG + G+ +R+ + EN G YQC
Sbjct: 351 PCVATGKPIPTIRWLKNGYAYHKGE-LRLYDVTFEN----------AGMYQCIAENTYGA 399
Query: 392 LSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGG 451
+ A ++++ T ++ + + + V + C K P P +W+ + ++
Sbjct: 400 IYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLV--N 457
Query: 452 SHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI--RP 509
S RI +I +G+ L I++ DGG+Y C A N+ G + + P I P
Sbjct: 458 SSRI--LIWEDGS----LEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 511
Query: 510 MKNITAIAGRDTYIHCRVIGYPYYSIK--WYKNSNLLPFN------HRQVAFENNGTLKL 561
+ N G + + C P + W N ++ FN R ++NG L +
Sbjct: 512 I-NADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLI 570
Query: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597
+ Q + G YTC ++S S + V+ PP
Sbjct: 571 RNAQLK-HAGRYTCTAQTIVD-NSSASADLVVRGPP 604
Score = 66.6 bits (161), Expect = 2e-10
Identities = 217/984 (22%), Positives = 360/984 (36%), Gaps = 157/984 (15%)
Query: 604 FPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNLSLM 662
+P S+ +V + C + P+ W+ + G + +T D +L I+N
Sbjct: 52 YPEESLEGKVSLNCRARASPFPV-YKWRMNN----GDVDLTSDRYSMVGGNLVINNPDKQ 106
Query: 663 HN-GNYTCIARNEAAAVEHQSQLIV-----RVPPKFVVQPRDQDGIYGKAVILNCSAEGY 716
+ G Y C+A N V + PP+ + R ++G K ++L C +
Sbjct: 107 KDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEG---KGMVLLCDPPYH 163
Query: 717 PVPTIVWKFSKGAGVPQFQPIALNGRIQVL-SNGSLLIKHVVEEDSGYYLCKVSNDVGAD 775
+ +++ P F I ++ R V +NG+L I +V D G Y C VS+
Sbjct: 164 FPDDLSYRWLLNE-FPVF--ITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSP---S 217
Query: 776 VSKSMY------------LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK 823
++KS++ T PA I A GQ + C A G +RW K
Sbjct: 218 ITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK 277
Query: 824 EDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQ 883
++ P + +ST + L+I ED G + C A N G+D+ ++ VQ
Sbjct: 278 ---VLEPMPSTAEISTSG------AVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQ 328
Query: 884 EPPDPPEIEIKDVKARTITLRWTMGFDGNSPI--TGYDIEC----KNKSDSWDSAQRTKD 937
P+ E I D + +G D P TG I KN R D
Sbjct: 329 AFPEWVE-HINDTEV-------DIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYD 380
Query: 938 VSPQLNSATIIDIHPSSTY-SIRMYAKNRIGKSEPSNELTITADEA-APDGPPQEVHLEP 995
V+ +A + +TY +I A+ +I P+ E+ + A G + +P
Sbjct: 381 VT--FENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKP 438
Query: 996 ISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLN 1055
++ + +W + L N +I E G+ + N I+ + G + +N
Sbjct: 439 KAAPKPKFSWSKGTEWLVNSS----RILIWE---DGSLEINNITRNDGGIYTCFAENNRG 491
Query: 1056 KFTQYG-LVVQACNRAGTGPSSQEIIT---TTLEDVPSYPPENVQAIATSPESISISWST 1111
K G LV+ R P + +I T++ S+ P ++ WS
Sbjct: 492 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPAL---------DLTFVWS- 541
Query: 1112 LSKEALNGILQGFR---VIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAF 1168
NG + F + Y N M GE+ + +L +YT A
Sbjct: 542 -----FNGYVIDFNKENIHYQRNFMLDSNGEL-----LIRNAQLKHAGRYT-----CTAQ 586
Query: 1169 TRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSH 1228
T + S + R PGPP G++ A+ V ++W + I KYT+
Sbjct: 587 TIVDNSSASADLVVRGP---PGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKT 643
Query: 1229 PYPTVISEFEASPDSF-----SYRIPNLSRNRQYSVWVVAVTSAGRGNSS---EIITVEP 1280
+ + P + R +L +Y VVA + GRG S I +
Sbjct: 644 ILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDG 703
Query: 1281 LAK--APARILTFSGT---VTTPWMK-----------DIVLPCKAVGDPSPAVKWMKDSN 1324
A AP+ + G +T W ++ K P +W K +
Sbjct: 704 AAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFK----PFDGEEWKKVTV 759
Query: 1325 GTPSLVTIDGRRSIFSNGSFIIRTVKA---EDSGYYSCIANNNWGSDEIILNLQVQVPPD 1381
P + S + VKA + G YS +A ++N P +
Sbjct: 760 TNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVA---------VINSAQDAPSE 810
Query: 1382 QP-RLTVSKTTSSSITLSWLPGDNGGSSIRGYILQY--SEDNSEQWGSFPISPSERSYRL 1438
P + V +SS I++ W + Y ++Y + D E ++ E S RL
Sbjct: 811 APTEVGVKVLSSSEISVHWEHVLE--KIVESYQIRYWAAHDKEEAANRVQVTSQEYSARL 868
Query: 1439 ENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIG 1498
ENL T Y + A N G G S++IEA T P S+ + +S+ + +I
Sbjct: 869 ENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPP--SQPPRIISSVRSG--SRYIIT 924
Query: 1499 WN-----DGGCPITSFTLEYRPFG 1517
W+ +T + + YRP G
Sbjct: 925 WDHVVALSNESTVTGYKVLYRPDG 948
Score = 55.8 bits (133), Expect = 4e-07
Identities = 67/286 (23%), Positives = 108/286 (37%), Gaps = 30/286 (10%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
+++ CK P P W K GT LV R I+ +GS I + D G Y+C A
Sbjct: 432 VIIECKPKAAPKPKFSWSK---GTEWLVN-SSRILIWEDGSLEINNITRNDGGIYTCFAE 487
Query: 1363 NNWGSDEIILNLQVQVP------PDQPRLTVSKTTSSSITLSWLPGDNGGS--SIRGYIL 1414
NN G L + P P +TV + + S+ P + S GY++
Sbjct: 488 NNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVI 547
Query: 1415 QYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474
++++N +F + S + N + ++T TAQ V S A + +
Sbjct: 548 DFNKENIHYQRNFMLD-SNGELLIRNAQLKHAGRYTCTAQTIVDNSSAS----ADLVVRG 602
Query: 1475 PQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYI 1534
P I T V L +D PI+ +T++ + + W A+ + I
Sbjct: 603 PPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAK----TDPPI 658
Query: 1535 LYDLQEAT-------WYELQMRV--CNSAGCAEKQANFATLNYDGS 1571
+ EA W E + RV N+ G E + DG+
Sbjct: 659 IEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGA 704
Score = 52.8 bits (125), Expect = 3e-06
Identities = 73/322 (22%), Positives = 121/322 (37%), Gaps = 54/322 (16%)
Query: 14 NVFSEDLHSSLYFVNASLQEVVFASTTGTLV------PCPAAGIPPVTLRWYLATGEEIY 67
N+ +D H + +V A + V + T + PC A G P T+RW L G
Sbjct: 314 NIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRW-LKNG---- 368
Query: 68 DVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYT 127
+ + G L+++ T + Y C AEN G I + + +K + P T
Sbjct: 369 ------YAYHKGELRLYDV------TFENAGMYQCIAENTYGAIYA-NAELKILALAP-T 414
Query: 128 VRVEDQK----TMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYI 183
+ K +G + +C ++ + SW K T LV+ SR LI G+L I
Sbjct: 415 FEMNPMKKKILAAKGGRVIIECKPKAAPKPKF---SWSKGTEWLVNSSRILIWEDGSLEI 471
Query: 184 KDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVE 243
++ DG Y C + + +++ L ++DP I+ + G+
Sbjct: 472 NNITRNDGGI-YTCFAEN---NRGKANSTGTLVITDPTR----IILAPINADITVGENAT 523
Query: 244 LPCKALGHPEPDYRWL-----------KDNMPLELSGRFQKTVTG-LLIENIRPSDSGSY 291
+ C A P D ++ K+N + F G LLI N + +G Y
Sbjct: 524 MQCAASFDPALDLTFVWSFNGYVIDFNKEN--IHYQRNFMLDSNGELLIRNAQLKHAGRY 581
Query: 292 VCEVSNRYGTAKVIGRLYVKQP 313
C + L V+ P
Sbjct: 582 TCTAQTIVDNSSASADLVVRGP 603
>gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]
Length = 1007
Score = 225 bits (574), Expect = 3e-58
Identities = 234/944 (24%), Positives = 392/944 (41%), Gaps = 92/944 (9%)
Query: 303 KVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSW-YRNGEILNPGKNVR 361
K G ++ +QP+ TI P + S+ +VSL+C + W NG++
Sbjct: 26 KGFGPIFEEQPIN-TIYPEE---SLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYS 81
Query: 362 ITGINHENLIMDHMVKS-DGGAYQCFVRKDKLSAQDYVQVVLEDGT-------PKIISAF 413
+ G NL++++ K D G Y C L++ +Y V + T P
Sbjct: 82 MVG---GNLVINNPDKQKDAGIYYC------LASNNYGMVRSTEATLSFGYLDPFPPEER 132
Query: 414 SEKVVSPAEPVSLMCNVKGTPLPTIT--WTLDDDPILKGGSHR--ISQMITSEGNVVSYL 469
E V + + L+C+ ++ W L++ P+ R +SQ + GN L
Sbjct: 133 PEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQ---TNGN----L 185
Query: 470 NISSSQVRDGGVYRCTANNSA----------GVVLYQARINVRGPASIR-PMKNITAIAG 518
I++ + D G Y C ++ + ++ R PA I K++ A+ G
Sbjct: 186 YIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMG 245
Query: 519 RDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVL 578
++ + C +G P I+W K L P + LK+ ++Q E DEG Y C
Sbjct: 246 QNVTLECFALGNPVPDIRWRKV--LEPMPSTAEISTSGAVLKIFNIQLE-DEGIYECEAE 302
Query: 579 VQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIP 638
Q+ P +++ IG ++ PCV +P TI W K+G
Sbjct: 303 NIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIP-TIRWLKNGYAY- 360
Query: 639 GSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQL-IVRVPPKFVVQPR 697
LR+ +++ + G Y CIA N A+ ++L I+ + P F + P
Sbjct: 361 -----------HKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPM 409
Query: 698 DQDGIYGKA--VILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKH 755
+ + K VI+ C + P P W SKG + + + RI + +GSL I +
Sbjct: 410 KKKILAAKGGRVIIECKPKAAPKPKFSW--SKGT-----EWLVNSSRILIWEDGSLEINN 462
Query: 756 VVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEK 815
+ D G Y C N+ G S L + P I P T G+ M C A +
Sbjct: 463 ITRNDGGIYTCFAENNRGKANSTGT-LVITDPTRIILAPINADITVGENATMQCAASFDP 521
Query: 816 PIIVR--WEKEDRII--NPEMARYLVS--TKEVGEEVISTLQILPTVREDSGFFSCHAIN 869
+ + W +I N E Y + GE +I Q+ + +G ++C A
Sbjct: 522 ALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQL-----KHAGRYTCTAQT 576
Query: 870 SYGEDRGIIQLTVQEPPDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDIECKN-KSD 927
L V+ PP PP + I+D++A ++ L W+ G D +SPI+ Y I+ K SD
Sbjct: 577 IVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSD 636
Query: 928 SWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELT-ITADEAAPD 985
W A+ + + +A +D+ P Y R+ A N +G+ EPS I D AAP+
Sbjct: 637 DWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPN 696
Query: 986 GPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGD 1045
P +V ++ + +TW + G GY + ++ + + + + DT
Sbjct: 697 VAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTG-- 754
Query: 1046 SEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESI 1105
V+ + ++ T + + V+A N G GP S + + +D PS P V S I
Sbjct: 755 RYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEI 814
Query: 1106 SISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQV 1165
S+ W + L I++ +++ YWA E +T+ + S L+ L T Y I+V
Sbjct: 815 SVHW----EHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEV 870
Query: 1166 LAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSW 1209
A AG G S+ I TK+ P P + ++ S S ++W
Sbjct: 871 GACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITW 914
Score = 187 bits (476), Expect = 7e-47
Identities = 238/994 (23%), Positives = 388/994 (39%), Gaps = 120/994 (12%)
Query: 241 RVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLLIEN--IRPSDSGSYVCEVSNR 298
+V L C+A P P Y+W +N ++L+ V G L+ N + D+G Y C SN
Sbjct: 49 KVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNN 108
Query: 299 YG----TAKVIGRLYVKQPLKATISPR-KVKSSVGSQVSLSCSVTGTEDQELSWYRNG-E 352
YG T + Y+ P P +VK G + +D W N
Sbjct: 109 YGMVRSTEATLSFGYL-DPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFP 167
Query: 353 ILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVV----LEDGTPK 408
+ R + NL + ++ SD G Y CFV ++ + + + + + T K
Sbjct: 168 VFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTK 227
Query: 409 -----IISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEG 463
I+ F + + V+L C G P+P I W +P+ + I++ G
Sbjct: 228 PYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPS------TAEISTSG 281
Query: 464 NVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG-PASIRPMKNITAIAGRDTY 522
V+ NI Q+ D G+Y C A N G +QARI V+ P + + + G D Y
Sbjct: 282 AVLKIFNI---QLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLY 338
Query: 523 IHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQ 582
C G P +I+W KN + G L+L DV E + G Y C +
Sbjct: 339 WPCVATGKPIPTIRWLKNGYAY----------HKGELRLYDVTFE-NAGMYQC---IAEN 384
Query: 583 LSTSQSVHVTVKVPPFIQPFEFPRF------SIGQRVFIPCVVVSGDLPITITWQKDGRP 636
+ + +K+ FE + G RV I C + P +W K
Sbjct: 385 TYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKP-KFSWSKGTEW 443
Query: 637 IPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQP 696
+ S + I SL I+N++ G YTC A N L++ P + ++ P
Sbjct: 444 LVNSSRILIWE---DGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500
Query: 697 RDQDGIYGKAVILNCSAEGYPV--PTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIK 754
+ D G+ + C+A P T VW F+ + I + SNG LLI+
Sbjct: 501 INADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIR 560
Query: 755 HVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGE 814
+ + +G Y C V + S S L V+ P G +
Sbjct: 561 NAQLKHAGRYTCTAQTIVD-NSSASADLVVRGP-------------PGPPGGLRIEDIRA 606
Query: 815 KPIIVRWEKEDRIINPEMARYLVSTK-----------------EVGEEVISTLQILPTVR 857
+ + W + +P +++Y + TK E E + ++P +
Sbjct: 607 TSVALTWSRGSDNHSP-ISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWME 665
Query: 858 EDSGFFSCHAINSYGE-DRGIIQLTVQEPPDPPEIEIKDV-----KARTITLRWT----M 907
+ F A N+ G + I ++ P + DV + R +T+ W
Sbjct: 666 YE---FRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSRE 722
Query: 908 GFDGNSPITGYDIECKN-KSDSWDSAQRTKDVSPQLNSATIID--IHPSSTYSIRMYAKN 964
GN+ GY + K + W T +P D + PS+ + +++ A N
Sbjct: 723 YHYGNN--FGYIVAFKPFDGEEWKKVTVT---NPDTGRYVHKDETMSPSTAFQVKVKAFN 777
Query: 965 RIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGY 1024
G S I + + AP P EV ++ +SS I V W +H+ I+ YQI
Sbjct: 778 NKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHW----EHVLEKIVESYQI-- 831
Query: 1025 REYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTL 1084
Y + + V + L+NL TQY + V ACN AG GP S I T
Sbjct: 832 -RYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTK 890
Query: 1085 EDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNIT 1144
+ PS PP + ++ + I I+W + + + G++V+Y DG+ + K +
Sbjct: 891 KAPPSQPPRIISSVRSGSRYI-ITWDHVVALSNESTVTGYKVLY---RPDGQ-HDGKLYS 945
Query: 1145 TTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSE 1178
T + S+E+ + + Y ++V A + GDGV S+
Sbjct: 946 THKHSIEVP-IPRDGEYVVEVRAHSDGGDGVVSQ 978
Score = 158 bits (399), Expect = 6e-38
Identities = 216/918 (23%), Positives = 358/918 (38%), Gaps = 116/918 (12%)
Query: 424 VSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYR 483
VSL C + +P P W +++ + S R S + GN+V +N Q +D G+Y
Sbjct: 50 VSLNCRARASPFPVYKWRMNNGDV-DLTSDRYSMV---GGNLV--INNPDKQ-KDAGIYY 102
Query: 484 CTANNSAGVVLYQARINVRG-----PASIRPMKNITAIAGRDTYIHCRVIGYPYY----- 533
C A+N+ G+V G P RP + G+ + C PY+
Sbjct: 103 CLASNNYGMVRSTEATLSFGYLDPFPPEERP--EVRVKEGKGMVLLCDP---PYHFPDDL 157
Query: 534 SIKWYKNSN--LLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHV 591
S +W N + + R+ + NG L +++V+ D+G Y+C V P ++ S
Sbjct: 158 SYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEAS-DKGNYSCFVS-SPSITKSVFSKF 215
Query: 592 TVKVP-----------PFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGS 640
+P + F+ +GQ V + C + +P I W+K P+P +
Sbjct: 216 IPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVP-DIRWRKVLEPMPST 274
Query: 641 LGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPPKFVVQPRDQD 700
++ + L+I N+ L G Y C A N +HQ+++ V+ P++V D +
Sbjct: 275 AEISTSG----AVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTE 330
Query: 701 GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEED 760
G + C A G P+PTI W NG G L + V E+
Sbjct: 331 VDIGSDLYWPCVATGKPIPTIRW--------------LKNG--YAYHKGELRLYDVTFEN 374
Query: 761 SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSY-----PNTTLATQGQKKEMSCTAHGEK 815
+G Y C N GA + + +KI A+ ++ LA +G + + C
Sbjct: 375 AGMYQCIAENTYGAIYANA---ELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAP 431
Query: 816 PIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDR 875
W K +LV++ + +L+I R D G ++C A N+ G+
Sbjct: 432 KPKFSWSKG--------TEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKAN 483
Query: 876 GIIQLTVQEPPDPPEIEIKDVKA-----RTITLRWTMGFDGNSPIT------GYDIECKN 924
L + DP I + + A T++ FD +T GY I+ N
Sbjct: 484 STGTLVI---TDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDF-N 539
Query: 925 KSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAP 984
K + D + +L I + A+ + S S +L + P
Sbjct: 540 KENIHYQRNFMLDSNGEL---LIRNAQLKHAGRYTCTAQTIVDNSSASADLVV----RGP 592
Query: 985 DGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSG 1044
GPP + +E I + S+ +TW + + I Y I + + G
Sbjct: 593 PGPPGGLRIEDIRATSVALTWSRGSDN--HSPISKYTIQTKTILSDDWKDAKTDPPIIEG 650
Query: 1045 DSEVYTLDNLNKFTQYGLVVQACNRAGTG-PSSQEIITTTLEDVPSYPPENVQAIATSPE 1103
+ E +L + +Y V A N G G PS T P+ P +V
Sbjct: 651 NMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNR 710
Query: 1104 SISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSL-----ELDGLEKY 1158
++I+W+ LS+E G G+ V + DGE E K +T T P + + +
Sbjct: 711 ELTITWAPLSREYHYGNNFGYIVAF--KPFDGE--EWKKVTVTNPDTGRYVHKDETMSPS 766
Query: 1159 TNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG-PPAGVKAAAASASMVFVSWLPPLKLNG 1217
T + ++V AF GDG S + +D P P V S+S + V W L
Sbjct: 767 TAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHW--EHVLEK 824
Query: 1218 IIRKYTV--FCSHPYPTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEI 1275
I+ Y + + +H + + + +S R+ NL + QY + V A SAG G S++
Sbjct: 825 IVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDM 884
Query: 1276 I---TVEPLAKAPARILT 1290
I T + P RI++
Sbjct: 885 IEAFTKKAPPSQPPRIIS 902
Score = 118 bits (295), Expect = 7e-26
Identities = 140/576 (24%), Positives = 224/576 (38%), Gaps = 60/576 (10%)
Query: 46 CPAAGIPPVTLRWYLATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAE 105
C A P +W + G+ D+ R+ G L I ++ YYC A
Sbjct: 54 CRARASPFPVYKWRMNNGD--VDLTSDRYSMVGGNLVI-----NNPDKQKDAGIYYCLAS 106
Query: 106 NPSGKIRSQDVHIKAVLREPYT------VRVEDQKTMRGNVAVFKCIIPSSVEAYITVVS 159
N G +RS + + +P+ VRV++ K M V C P ++
Sbjct: 107 NNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGM-----VLLCDPPYHFPDDLSY-R 160
Query: 160 W---EKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLF 216
W E + RF+ + G LYI +V+ D NY C ++ S L
Sbjct: 161 WLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDK-GNYSCFVSSPSITKSVFSKFIPLI 219
Query: 217 VSDPANSAP---SILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQK 273
+ P I+ F A+ GQ V L C ALG+P PD RW K P+ +
Sbjct: 220 PIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEIST 279
Query: 274 TVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSL 333
+ L I NI+ D G Y CE N G K R+YV+ + + +GS +
Sbjct: 280 SGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYW 339
Query: 334 SCSVTGTEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRK--DK 391
C TG + W +NG + G+ +R+ + EN G YQC
Sbjct: 340 PCVATGKPIPTIRWLKNGYAYHKGE-LRLYDVTFEN----------AGMYQCIAENTYGA 388
Query: 392 LSAQDYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGG 451
+ A ++++ T ++ + + + V + C K P P +W+ + ++
Sbjct: 389 IYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLV--N 446
Query: 452 SHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI--RP 509
S RI +I +G+ L I++ DGG+Y C A N+ G + + P I P
Sbjct: 447 SSRI--LIWEDGS----LEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAP 500
Query: 510 MKNITAIAGRDTYIHCRVIGYPYYSIK--WYKNSNLLPFN------HRQVAFENNGTLKL 561
+ N G + + C P + W N ++ FN R ++NG L +
Sbjct: 501 I-NADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLI 559
Query: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597
+ Q + G YTC ++S S + V+ PP
Sbjct: 560 RNAQLK-HAGRYTCTAQTIVD-NSSASADLVVRGPP 593
Score = 66.6 bits (161), Expect = 2e-10
Identities = 217/984 (22%), Positives = 360/984 (36%), Gaps = 157/984 (15%)
Query: 604 FPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTS-SLRISNLSLM 662
+P S+ +V + C + P+ W+ + G + +T D +L I+N
Sbjct: 41 YPEESLEGKVSLNCRARASPFPV-YKWRMNN----GDVDLTSDRYSMVGGNLVINNPDKQ 95
Query: 663 HN-GNYTCIARNEAAAVEHQSQLIV-----RVPPKFVVQPRDQDGIYGKAVILNCSAEGY 716
+ G Y C+A N V + PP+ + R ++G K ++L C +
Sbjct: 96 KDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEG---KGMVLLCDPPYH 152
Query: 717 PVPTIVWKFSKGAGVPQFQPIALNGRIQVL-SNGSLLIKHVVEEDSGYYLCKVSNDVGAD 775
+ +++ P F I ++ R V +NG+L I +V D G Y C VS+
Sbjct: 153 FPDDLSYRWLLNE-FPVF--ITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSP---S 206
Query: 776 VSKSMY------------LTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEK 823
++KS++ T PA I A GQ + C A G +RW K
Sbjct: 207 ITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRK 266
Query: 824 EDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQ 883
++ P + +ST + L+I ED G + C A N G+D+ ++ VQ
Sbjct: 267 ---VLEPMPSTAEISTSG------AVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQ 317
Query: 884 EPPDPPEIEIKDVKARTITLRWTMGFDGNSPI--TGYDIEC----KNKSDSWDSAQRTKD 937
P+ E I D + +G D P TG I KN R D
Sbjct: 318 AFPEWVE-HINDTEV-------DIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYD 369
Query: 938 VSPQLNSATIIDIHPSSTY-SIRMYAKNRIGKSEPSNELTITADEA-APDGPPQEVHLEP 995
V+ +A + +TY +I A+ +I P+ E+ + A G + +P
Sbjct: 370 VT--FENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKP 427
Query: 996 ISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLN 1055
++ + +W + L N +I E G+ + N I+ + G + +N
Sbjct: 428 KAAPKPKFSWSKGTEWLVNSS----RILIWE---DGSLEINNITRNDGGIYTCFAENNRG 480
Query: 1056 KFTQYG-LVVQACNRAGTGPSSQEIIT---TTLEDVPSYPPENVQAIATSPESISISWST 1111
K G LV+ R P + +I T++ S+ P ++ WS
Sbjct: 481 KANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPAL---------DLTFVWS- 530
Query: 1112 LSKEALNGILQGFR---VIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAF 1168
NG + F + Y N M GE+ + +L +YT A
Sbjct: 531 -----FNGYVIDFNKENIHYQRNFMLDSNGEL-----LIRNAQLKHAGRYT-----CTAQ 575
Query: 1169 TRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSH 1228
T + S + R PGPP G++ A+ V ++W + I KYT+
Sbjct: 576 TIVDNSSASADLVVRGP---PGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKT 632
Query: 1229 PYPTVISEFEASPDSF-----SYRIPNLSRNRQYSVWVVAVTSAGRGNSS---EIITVEP 1280
+ + P + R +L +Y VVA + GRG S I +
Sbjct: 633 ILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDG 692
Query: 1281 LAK--APARILTFSGT---VTTPWMK-----------DIVLPCKAVGDPSPAVKWMKDSN 1324
A AP+ + G +T W ++ K P +W K +
Sbjct: 693 AAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFK----PFDGEEWKKVTV 748
Query: 1325 GTPSLVTIDGRRSIFSNGSFIIRTVKA---EDSGYYSCIANNNWGSDEIILNLQVQVPPD 1381
P + S + VKA + G YS +A ++N P +
Sbjct: 749 TNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVA---------VINSAQDAPSE 799
Query: 1382 QP-RLTVSKTTSSSITLSWLPGDNGGSSIRGYILQY--SEDNSEQWGSFPISPSERSYRL 1438
P + V +SS I++ W + Y ++Y + D E ++ E S RL
Sbjct: 800 APTEVGVKVLSSSEISVHWEHVLE--KIVESYQIRYWAAHDKEEAANRVQVTSQEYSARL 857
Query: 1439 ENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINTTRVRLNLIG 1498
ENL T Y + A N G G S++IEA T P S+ + +S+ + +I
Sbjct: 858 ENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPP--SQPPRIISSVRSG--SRYIIT 913
Query: 1499 WN-----DGGCPITSFTLEYRPFG 1517
W+ +T + + YRP G
Sbjct: 914 WDHVVALSNESTVTGYKVLYRPDG 937
Score = 55.8 bits (133), Expect = 4e-07
Identities = 67/286 (23%), Positives = 108/286 (37%), Gaps = 30/286 (10%)
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIAN 1362
+++ CK P P W K GT LV R I+ +GS I + D G Y+C A
Sbjct: 421 VIIECKPKAAPKPKFSWSK---GTEWLVN-SSRILIWEDGSLEINNITRNDGGIYTCFAE 476
Query: 1363 NNWGSDEIILNLQVQVP------PDQPRLTVSKTTSSSITLSWLPGDNGGS--SIRGYIL 1414
NN G L + P P +TV + + S+ P + S GY++
Sbjct: 477 NNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVI 536
Query: 1415 QYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKE 1474
++++N +F + S + N + ++T TAQ V S A + +
Sbjct: 537 DFNKENIHYQRNFMLD-SNGELLIRNAQLKHAGRYTCTAQTIVDNSSAS----ADLVVRG 591
Query: 1475 PQFSKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTTVWTTAQRTSLSKSYI 1534
P I T V L +D PI+ +T++ + + W A+ + I
Sbjct: 592 PPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAK----TDPPI 647
Query: 1535 LYDLQEAT-------WYELQMRV--CNSAGCAEKQANFATLNYDGS 1571
+ EA W E + RV N+ G E + DG+
Sbjct: 648 IEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGA 693
Score = 52.8 bits (125), Expect = 3e-06
Identities = 73/322 (22%), Positives = 121/322 (37%), Gaps = 54/322 (16%)
Query: 14 NVFSEDLHSSLYFVNASLQEVVFASTTGTLV------PCPAAGIPPVTLRWYLATGEEIY 67
N+ +D H + +V A + V + T + PC A G P T+RW L G
Sbjct: 303 NIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRW-LKNG---- 357
Query: 68 DVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYT 127
+ + G L+++ T + Y C AEN G I + + +K + P T
Sbjct: 358 ------YAYHKGELRLYDV------TFENAGMYQCIAENTYGAIYA-NAELKILALAP-T 403
Query: 128 VRVEDQK----TMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALYI 183
+ K +G + +C ++ + SW K T LV+ SR LI G+L I
Sbjct: 404 FEMNPMKKKILAAKGGRVIIECKPKAAPKPKF---SWSKGTEWLVNSSRILIWEDGSLEI 460
Query: 184 KDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVE 243
++ DG Y C + + +++ L ++DP I+ + G+
Sbjct: 461 NNITRNDGGI-YTCFAEN---NRGKANSTGTLVITDPTR----IILAPINADITVGENAT 512
Query: 244 LPCKALGHPEPDYRWL-----------KDNMPLELSGRFQKTVTG-LLIENIRPSDSGSY 291
+ C A P D ++ K+N + F G LLI N + +G Y
Sbjct: 513 MQCAASFDPALDLTFVWSFNGYVIDFNKEN--IHYQRNFMLDSNGELLIRNAQLKHAGRY 570
Query: 292 VCEVSNRYGTAKVIGRLYVKQP 313
C + L V+ P
Sbjct: 571 TCTAQTIVDNSSASADLVVRGP 592
>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
sapiens]
Length = 1304
Score = 221 bits (564), Expect = 4e-57
Identities = 254/1035 (24%), Positives = 412/1035 (39%), Gaps = 112/1035 (10%)
Query: 310 VKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRIT-----G 364
V+ P SP+ + + C G SW RNG + K+ +T G
Sbjct: 43 VQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTG 102
Query: 365 INHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTPKIISAFSEKV-VSPAEP 423
N++ + ++ G YQC R ++ +A VV +P E + + +
Sbjct: 103 TLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQS 162
Query: 424 VSLMCNVK-GTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVY 482
+ L C G P P I W +D+ S R+SQ + + + + N+ R+ Y
Sbjct: 163 LVLPCRPPIGLPPPIIFW-MDNSFQRLPQSERVSQGLNGD---LYFSNVLPEDTRED--Y 216
Query: 483 RCTAN-----------------------------NSAGVVLYQARIN-VRGPASIRPMKN 512
C A N + Y A+ + R P + P N
Sbjct: 217 ICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGN 276
Query: 513 IT---AIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVD 569
+ + G + C G P I W K +LP N R V TL++ V E D
Sbjct: 277 ASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKN-RTVYKNFEKTLQIIHVS-EAD 334
Query: 570 EGEYTCNVLVQPQLSTSQSVHVTVKVPPF-IQPFEFPRFSIGQRVFIPCVVVSGDLPITI 628
G Y C + + ++ V VK P+ I + S G+ + C P I
Sbjct: 335 SGNYQC-IAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKP-RI 392
Query: 629 TWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRV 688
+W +G PI + ID ++ SN+ + Y C A NE + + + V
Sbjct: 393 SWLTNGVPIEIAPDDPSRKID-GDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLA 451
Query: 689 PPKFVVQPRDQ--DGIYGKAVILNCSAEGYPVPTIVW-KFSKGAGVPQFQPIALNGRIQV 745
P ++ P + I + +L+C+ G P+PTI W K +KG+ AL+ I V
Sbjct: 452 EPPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGS--------ALHEDIYV 503
Query: 746 L-SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQK 804
L NG+L I ++ +G Y C N +G ++L +K P I P + +G
Sbjct: 504 LHENGTLEIPVAQKDSTGTYTCVARNKLGM-AKNEVHLEIKDPTWIVKQPEYAVVQRGSM 562
Query: 805 KEMSCTAHGEKPI--IVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF 862
C + + V W K++R + P R+ V L + +DSG
Sbjct: 563 VSFECKVKHDHTLSLTVLWLKDNREL-PSDERFTVDKDH--------LVVADVSDDDSGT 613
Query: 863 FSCHAINSYGEDRGIIQLTVQEP----------PDPP-EIEIKDVKARTITLRWTMGFDG 911
++C A + L+V P P+PP ++E+ D +++ L WT G D
Sbjct: 614 YTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDN 673
Query: 912 NSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEP 971
NSPIT + IE ++ +VS +A + + P YS R+ A N IGKS P
Sbjct: 674 NSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQL-KLSPYVNYSFRVMAVNSIGKSLP 732
Query: 972 SNELTITADEAA-PDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTG 1030
S +A+ PD P V ++ +TWK NG Y++ +R+ G
Sbjct: 733 SEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVSWRQ-KDG 791
Query: 1031 GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSY 1090
+ +++ + S Y + F Y + VQA N G P ++ + ED+P
Sbjct: 792 DDEWTSVVVANVSK----YIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMV 847
Query: 1091 PPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGE---IKNITTTQ 1147
P NV+ + + W + +++ G LQG+R+ YW + K I T Q
Sbjct: 848 APGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQ 907
Query: 1148 PSLE---LDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASM 1204
S L GLE +++Y++ V G+G S T E VP P+ +K +
Sbjct: 908 GSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDS 967
Query: 1205 VFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASP--------DSFSYRIPNLSRNRQ 1256
+ + W PP NGI+ +YT+ Y + S E P + + + NL+ + +
Sbjct: 968 LTLEWDPPSHPNGILTEYTL----KYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTR 1023
Query: 1257 YSVWVVAVTSAGRGN 1271
Y + A TSAG G+
Sbjct: 1024 YKFYFYAQTSAGSGS 1038
Score = 112 bits (281), Expect = 3e-24
Identities = 141/597 (23%), Positives = 227/597 (38%), Gaps = 59/597 (9%)
Query: 18 EDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYL-ATGEEIYDVPGIRHVH 76
EDL S ++ + ++ C A G PP + W T +I P +
Sbjct: 40 EDLVQPPTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP 99
Query: 77 PNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLREPYTVRVEDQKTM 136
GTL I T ++ Y CTA N G S ++ ++ +T + T+
Sbjct: 100 GTGTLIINIMSEGKAET--YEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITL 157
Query: 137 R-GNVAVFKCIIPSSVEAYITVVSWEKDTVS-LVSGSRFLITSTGALYIKDVQNEDGLYN 194
+ G V C P + ++ W ++ L R G LY +V ED +
Sbjct: 158 QSGQSLVLPCRPPIGLPP--PIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTRED 215
Query: 195 YRCITR--HRYTGETRQSNSARLFVSDPANSA--------------------PSILD--- 229
Y C R H T + +Q S ++ D N P+ L
Sbjct: 216 YICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEG 275
Query: 230 GFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLELSG----RFQKTVTGLLIENIRP 285
+++ + G + L C A G P P W K++ L + F+KT L I ++
Sbjct: 276 NASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYKNFEKT---LQIIHVSE 332
Query: 286 SDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQEL 345
+DSG+Y C N G + VK +P+ + S G +L C G +
Sbjct: 333 ADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLICRANGNPKPRI 392
Query: 346 SWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKD--KLSAQDYVQVVLE 403
SW NG + + I+ + +I ++ + YQC + L A +V V+ E
Sbjct: 393 SWLTNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAE 452
Query: 404 DGTPKIIS-AFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGS-HRISQMITS 461
P+I++ A + V P L C G+PLPTI W KG + H ++
Sbjct: 453 --PPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKG----AKGSALHEDIYVLHE 506
Query: 462 EGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASIRPMKNITAI-AGRD 520
G L I +Q G Y C A N G+ + + ++ P I + G
Sbjct: 507 NGT----LEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSM 562
Query: 521 TYIHCRVIGYPYYS--IKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
C+V S + W K++ LP + R +++ L ++DV + D G YTC
Sbjct: 563 VSFECKVKHDHTLSLTVLWLKDNRELPSDERFTVDKDH--LVVADVSDD-DSGTYTC 616
Score = 61.6 bits (148), Expect = 7e-09
Identities = 72/291 (24%), Positives = 117/291 (40%), Gaps = 35/291 (12%)
Query: 1307 CKAVGDP--SPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNN 1364
CK D S V W+KD+ PS R ++ V +DSG Y+C+AN
Sbjct: 567 CKVKHDHTLSLTVLWLKDNRELPS-----DERFTVDKDHLVVADVSDDDSGTYTCVANTT 621
Query: 1365 WGSDEIILNLQVQVPPDQPR-----------LTVSKTTSSSITLSWLPGDNGGSSIRGYI 1413
S L V P P L ++ S+ LSW PGD+ S I +I
Sbjct: 622 LDSVSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFI 681
Query: 1414 LQYSEDNSEQWGSF----PISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAK 1469
++Y ED + G + +S ++ + +L+ L Y F + A N +G SE E +
Sbjct: 682 IEY-EDAMHKPGLWHHQTEVSGTQTTAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASE-Q 738
Query: 1470 TLGKEPQFSKEQELFASINTTRVRLNLIGWN-----DGGCPITSFTLEYR-PFGTTVWTT 1523
L K + K + + L +I W + P + + +R G WT+
Sbjct: 739 YLTKASEPDKNPTAVEGLGSEPDNL-VITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTS 797
Query: 1524 AQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDGSTIP 1574
++SK YI+ Y ++++ N G A + A + + G +P
Sbjct: 798 VVVANVSK-YIVSGTPTFVPYLIKVQALNDMGFAPEPA--VVMGHSGEDLP 845
Score = 54.3 bits (129), Expect = 1e-06
Identities = 115/533 (21%), Positives = 197/533 (36%), Gaps = 77/533 (14%)
Query: 1086 DVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYW-ANLMDGELGEIKNIT 1144
DVP+ PP +++ +S+ +SW+ N + F + Y A G ++
Sbjct: 645 DVPN-PPFDLELTDQLDKSVQLSWTPGDDN--NSPITKFIIEYEDAMHKPGLWHHQTEVS 701
Query: 1145 TTQPSLELDGLEKYTNYSIQVLAFTRAGDGV---RSEQIFTRTKEDVPGPPAGVKAAAAS 1201
TQ + +L L Y NYS +V+A G + SEQ T+ E P A V+ +
Sbjct: 702 GTQTTAQLK-LSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTA-VEGLGSE 759
Query: 1202 ASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSRNR------ 1255
+ ++W P LNG Y + + + S + N+S+
Sbjct: 760 PDNLVITWKP---LNGFESNGPGL---QYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPT 813
Query: 1256 --QYSVWVVAVTSAG--------RGNSSEIITVEPLAKAPARILTFSGTVTTPWMKDIVL 1305
Y + V A+ G G+S E + + +A R+ + T+ +
Sbjct: 814 FVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPM--VAPGNVRVNVVNSTLAEVHWDPV-- 869
Query: 1306 PCKAVGDPSPAVK---WMKDSNGTPS-------LVTIDGRRSI--------FSNGSFIIR 1347
P K++ + W S+ + ++T G ++ FS+ + +R
Sbjct: 870 PLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVR 929
Query: 1348 TVKAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGS 1407
V + G S + + N VP L + T S+TL W P +
Sbjct: 930 VVNGKGEGP---------ASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNG 980
Query: 1408 SIRGYILQYSEDNS-EQWG---SFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPG--- 1460
+ Y L+Y NS + G I ++ + L+NL T YKF AQ G G
Sbjct: 981 ILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQI 1040
Query: 1461 ---RISEIIEAKTLGKEPQFSKEQELFASI-NTTRVRLNL---IGWNDGGCPITSFTLEY 1513
++ + EA L + K Q + I N T I W G +F +EY
Sbjct: 1041 TEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEHVNFYVEY 1100
Query: 1514 RPFGTTVWTTAQRTSLSKSYI-LYDLQEATWYELQMRVCNSAGCAEKQANFAT 1565
G+ + + S+S+ L L T Y++++ +G + F T
Sbjct: 1101 GVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAVGDSGFVSSEDVFET 1153
Score = 53.9 bits (128), Expect = 2e-06
Identities = 81/349 (23%), Positives = 131/349 (37%), Gaps = 69/349 (19%)
Query: 578 LVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPI 637
LVQP T QS + I P E + I C G P + +W ++G
Sbjct: 42 LVQPPTITQQSPKDYI-----IDPRE--------NIVIQCEA-KGKPPPSFSWTRNGTHF 87
Query: 638 PGSLGVTIDNIDFTSSLRISNLSL----MHNGNYTCIARNEAAAVEHQSQLIVRVPPKFV 693
+ T +L I+ +S + G Y C ARNE A + ++VR +
Sbjct: 88 DIDKDPLVTMKPGTGTLIINIMSEGKAETYEGVYQCTARNERGAAV-SNNIVVRPSRSPL 146
Query: 694 VQPRDQDGI---YGKAVILNCSAE-GYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNG 749
+ I G++++L C G P P I W + FQ + + R+ NG
Sbjct: 147 WTKEKLEPITLQSGQSLVLPCRPPIGLPPPIIFWMDN------SFQRLPQSERVSQGLNG 200
Query: 750 SLLIKHVVEEDSGY-YLC------------------------KVSNDVGADVSKSMYLTV 784
L +V+ ED+ Y+C ++++ + A++S + +
Sbjct: 201 DLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVISVDELNDTIAANLSDTEFYGA 260
Query: 785 KI-----PAMITSYPNTTLATQ--GQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLV 837
K P +T N + + G + C A G I+ W KED + L
Sbjct: 261 KSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPTPIIYWAKEDGM--------LP 312
Query: 838 STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886
+ V + TLQI+ DSG + C A N+ G I + V+ P
Sbjct: 313 KNRTVYKNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAP 361
Score = 51.2 bits (121), Expect = 1e-05
Identities = 62/246 (25%), Positives = 99/246 (40%), Gaps = 26/246 (10%)
Query: 950 IHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPK 1009
+ P S Y++ + N G+ S + E P P + P + S+ + W P
Sbjct: 918 LEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNP-TLDSLTLEWDPPS 976
Query: 1010 KHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNR 1069
NGI+ Y + Y+ ++ ++ + + +TL NLN T+Y A
Sbjct: 977 H--PNGILTEYTLKYQPINSTHELG-PLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTS 1033
Query: 1070 AGTGPSSQEIITTTLEDVPSYPPE----NVQAI---------ATSPESISISWSTLSKEA 1116
AG+G E TT+++ PP+ VQA+ A + +ISW E
Sbjct: 1034 AGSGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEH 1093
Query: 1117 LNGILQGFRVIYW-ANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGV 1175
+N F V Y A + EI N ++ L GL T Y ++V A +G V
Sbjct: 1094 VN-----FYVEYGVAGSKEEWRKEIVN--GSRSFFGLKGLMPGTAYKVRVGAVGDSG-FV 1145
Query: 1176 RSEQIF 1181
SE +F
Sbjct: 1146 SSEDVF 1151
Score = 50.1 bits (118), Expect = 2e-05
Identities = 78/351 (22%), Positives = 124/351 (35%), Gaps = 31/351 (8%)
Query: 4 LALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYLATG 63
+A + + + S + ++ Y++ A V+ GTL+ C A G P + W L G
Sbjct: 341 IAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDGTLI-CRANGNPKPRISW-LTNG 398
Query: 64 EEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLIHDNTYYCTAENPSGKIRSQDVHIKAVLR 123
I P +G IF S + Y C A N G + + VL
Sbjct: 399 VPIEIAPDDPSRKIDGDTIIFSNVQERSSAV-----YQCNASNEYGYLLANA--FVNVLA 451
Query: 124 EPYTVRVEDQ---KTMRGNVAVFKCIIPSSVEAYITVVSWEKDTV-SLVSGSRFLITSTG 179
EP + + + A+ C S + + W K S + +++ G
Sbjct: 452 EPPRILTPANTLYQVIANRPALLDCAFFGSP---LPTIEWFKGAKGSALHEDIYVLHENG 508
Query: 180 ALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAG 239
L I V +D Y C+ R++ N L + DP I+ ++ G
Sbjct: 509 TLEIP-VAQKDSTGTYTCVARNKLG---MAKNEVHLEIKDPT----WIVKQPEYAVVQRG 560
Query: 240 QRVELPCKALGHPEP---DYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSYVCEVS 296
V CK + H WLKDN L RF L++ ++ DSG+Y C +
Sbjct: 561 SMVSFECK-VKHDHTLSLTVLWLKDNRELPSDERFTVDKDHLVVADVSDDDSGTYTCVAN 619
Query: 297 NRYGTAKVIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSW 347
+ L V P T +P V L + + +LSW
Sbjct: 620 TTLDSVSASAVLSVVAP---TPTPAPVYDVPNPPFDLELTDQLDKSVQLSW 667
Score = 47.0 bits (110), Expect = 2e-04
Identities = 36/148 (24%), Positives = 61/148 (41%), Gaps = 13/148 (8%)
Query: 1253 RNRQYSVWVVAVTSAGRGNSSEII---------TVEPLAKAPARILTFSGTVTTPWMKDI 1303
+N + ++ ++ V+ A GN I T+ KA +T + +D
Sbjct: 319 KNFEKTLQIIHVSEADSGNYQCIAKNALGAIHHTISVRVKAAPYWITAPQNLVLSPGEDG 378
Query: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
L C+A G+P P + W+ +NG P + D + I V+ S Y C A+N
Sbjct: 379 TLICRANGNPKPRISWL--TNGVPIEIAPDDPSRKIDGDTIIFSNVQERSSAVYQCNASN 436
Query: 1364 NWGSDEIILNLQVQVPPDQPRLTVSKTT 1391
+G ++ N V V + PR+ T
Sbjct: 437 EYG--YLLANAFVNVLAEPPRILTPANT 462
Score = 42.7 bits (99), Expect = 0.004
Identities = 26/96 (27%), Positives = 47/96 (48%), Gaps = 4/96 (4%)
Query: 1285 PARILTFSGTVTTPWM-KDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGS 1343
P RILT + T+ + +L C G P P ++W K + G+ I + NG+
Sbjct: 453 PPRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDI---YVLHENGT 509
Query: 1344 FIIRTVKAEDSGYYSCIANNNWGSDEIILNLQVQVP 1379
I + + +G Y+C+A N G + ++L+++ P
Sbjct: 510 LEIPVAQKDSTGTYTCVARNKLGMAKNEVHLEIKDP 545
Score = 39.3 bits (90), Expect = 0.039
Identities = 33/140 (23%), Positives = 59/140 (42%), Gaps = 16/140 (11%)
Query: 1251 LSRNRQYSVWVVAV-----TSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWM---KD 1302
+ + + SV V++V T A + +E + + P LT G +
Sbjct: 228 IQQKQPISVKVISVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNV 287
Query: 1303 IVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAE--DSGYYSCI 1360
+ L C A G P+P + W K+ P R+++ N ++ + DSG Y CI
Sbjct: 288 LSLECIAEGLPTPIIYWAKEDGMLPK------NRTVYKNFEKTLQIIHVSEADSGNYQCI 341
Query: 1361 ANNNWGSDEIILNLQVQVPP 1380
A N G+ ++++V+ P
Sbjct: 342 AKNALGAIHHTISVRVKAAP 361
Score = 32.3 bits (72), Expect = 4.8
Identities = 28/95 (29%), Positives = 41/95 (43%), Gaps = 11/95 (11%)
Query: 1301 KDIVLPCKAVGDPSPAVKWMK-----DSNGTPSLVTIDGRRSIFSNGSFIIRTVKAED-S 1354
++IV+ C+A G P P+ W + D + P + G ++ N I+ KAE
Sbjct: 62 ENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPGTGTLIIN---IMSEGKAETYE 118
Query: 1355 GYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSK 1389
G Y C A N G+ + N V P P T K
Sbjct: 119 GVYQCTARNERGA--AVSNNIVVRPSRSPLWTKEK 151
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 219 bits (559), Expect = 2e-56
Identities = 253/993 (25%), Positives = 410/993 (41%), Gaps = 106/993 (10%)
Query: 621 SGDLPITITWQKDGRPIPGSLGVTIDNIDFTSS-LRISNLSLMHN-GNYTCIARNEAAAV 678
+GD I W K G+ + I+ D + S LRI L + Y C+A N +
Sbjct: 48 TGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEI 107
Query: 679 EHQSQLIV----RVP---PKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGV 731
++L V ++P P + P+ + + + C+A G P P I W
Sbjct: 108 SVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITW-------F 160
Query: 732 PQFQPIAL---NGRIQVLSN---------GSLLIKHVVEEDSGYYLCKVSNDVGADVSKS 779
F P+ NGRI+ L + G+L I+ E D G Y C +N G S
Sbjct: 161 KDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAP 220
Query: 780 MYLTVK-------IPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEM 832
L V+ +P + P G ++C A G V+W + PE
Sbjct: 221 ANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPE- 279
Query: 833 ARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPEIE 892
+G V+ L VR+ + + +C A+++ G I Q+TV+ P PP
Sbjct: 280 -----DDMPIGRNVLE----LNDVRQSANY-TCVAMSTLGVIEAIAQITVKALPKPPGTP 329
Query: 893 I-KDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSA-TIIDI 950
+ + A +ITL W G P++ Y I+ K K+ S + K++ + ++ +
Sbjct: 330 VVTESTATSITLTWDSG--NPEPVSYYIIQHKPKN----SEELYKEIDGVATTRYSVAGL 383
Query: 951 HPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKK 1010
P S Y R+ A N IG+ PS + E AP P++V +SS +I V WK P++
Sbjct: 384 SPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEE 443
Query: 1011 HLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRA 1070
NG I+GY++ Y T N DS++ T+ NL Y + V A
Sbjct: 444 --PNGQIQGYRVYYTMDPTQ---HVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI 498
Query: 1071 GTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWA 1130
G GP S +I T VP P N +A S SI +SW+ + + + ++Y
Sbjct: 499 GDGPLSSDIQVITQTGVPGQPL-NFKAEPESETSILLSWTPPRSDTI----ANYELVY-- 551
Query: 1131 NLMDGELGEIKNITTTQ-PSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP 1189
DGE GE + IT S L GL+ + Y ++ A + G G + +I RT + P
Sbjct: 552 --KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKP 609
Query: 1190 G-PPAGVKAAAASASMVFVSWLPPL--KLNGIIRKYTVFCSHPYPTVISEFEAS------ 1240
PP + + S++ + VSW PP K NGII +Y++ Y V E +
Sbjct: 610 SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSI----KYTAVDGEDDKPHEILGI 665
Query: 1241 -PDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITV---EPLAKAPARILTF----S 1292
D+ Y + L + +Y + V A T G G S + + E + P R + S
Sbjct: 666 PSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 725
Query: 1293 GTVTTPWMKDIVLPCKAVGD-PSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKA 1351
+V W + P K G V +++ NG P + + II ++
Sbjct: 726 TSVKVSWRSPV--PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQP 783
Query: 1352 EDSGYYSCIANNNWGS---DEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSS 1408
E S + A G + L P +PRL ++ T ++ + W P +
Sbjct: 784 ETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGP 843
Query: 1409 IRGYILQYSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEA 1468
++GY L++ + E + S E + ++ G Y F L+A+N VG G E+++
Sbjct: 844 LQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFG--EEMVKE 901
Query: 1469 KTLGKEPQFSKEQELFASINT-TRVRLN----LIGWNDGGCPITSFTLEYRPFGTTVWTT 1523
++ +E Q L + T T V+L+ ++ +G IT +TL YR +
Sbjct: 902 ISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNG--IITKYTLLYRDINIPLLPM 959
Query: 1524 AQR-TSLSKSYILYDLQEATWYELQMRVCNSAG 1555
Q + L L+ T Y++++R S G
Sbjct: 960 EQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKG 992
Score = 202 bits (514), Expect = 3e-51
Identities = 259/1054 (24%), Positives = 414/1054 (39%), Gaps = 120/1054 (11%)
Query: 504 PASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGT---LK 560
P R + T ++G C+ G P I W K + +V ++G+ L+
Sbjct: 24 PRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLR 83
Query: 561 LSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVKVPPFIQPFEF-PRFSIGQRVFIP 616
+ ++ DE Y C N + + +ST +V ++P + P+ + +R
Sbjct: 84 IQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTA 143
Query: 617 CVV--VSGDLPITITWQKDGRPIPGS---------LGVTIDNIDFTSSLRISNLSLMHNG 665
++ SG+ ITW KD P+ S +I +L+I G
Sbjct: 144 TMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQG 203
Query: 666 NYTCIARNEAAA--------VEHQSQLIVRVPPKFVVQPRDQDGIYGKAVILNCSAEGYP 717
Y C+A N A + + + RVPP+F + P + + + G +V + C A G P
Sbjct: 204 KYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSP 263
Query: 718 VPTIVWKFSKGAGVPQFQ-PIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADV 776
+P + W P+ PI N VL + S Y C + +G +
Sbjct: 264 MPYVKWMLGAEDLTPEDDMPIGRN----VLELNDV-------RQSANYTCVAMSTLGV-I 311
Query: 777 SKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPE-MARY 835
+TVK + P T + T+ ++ T W+ NPE ++ Y
Sbjct: 312 EAIAQITVKA---LPKPPGTPVVTESTATSITLT----------WDSG----NPEPVSYY 354
Query: 836 LVSTK-EVGEEVISTLQILPTVREDSGFFSCH--------AINSYGEDRGIIQLTVQEPP 886
++ K + EE+ + + T R S + A+N+ G + Q
Sbjct: 355 IIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSE 414
Query: 887 DPPEIEIKDVKAR-----TITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQ 941
P +DV+AR TI ++W + N I GY + + +V+
Sbjct: 415 QAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADS 474
Query: 942 LNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSI 1001
TI ++ P TYS+++ A IG S+++ + P G P EP S SI
Sbjct: 475 -QITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVP-GQPLNFKAEPESETSI 532
Query: 1002 RVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYG 1061
++W P+ + I Y++ Y++ G + I G S Y L L + Y
Sbjct: 533 LLSWTPPR----SDTIANYELVYKDGEHGEEQRITI----EPGTS--YRLQGLKPNSLYY 582
Query: 1062 LVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGIL 1121
+ A + G G S+ EI T++ PS PP+++ + S SI +SW E NGI+
Sbjct: 583 FRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGII 642
Query: 1122 QGFRVIYWANLMDGELG---EIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSE 1178
+ + Y A +DGE EI I + L+ LEK+T Y I V A T G G S
Sbjct: 643 TEYSIKYTA--VDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESL 700
Query: 1179 QIFTRTKEDVP-GPPAGVKAAAASASMVFVSWLPPL--KLNGIIRKYTVFC-----SHPY 1230
+ RT EDVP GPP V+ A +++ V VSW P+ K +G IR Y V P
Sbjct: 701 SVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPK 760
Query: 1231 PTVISEFEASPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARI-L 1289
+ + D+ I L YS+ V A T+ G G S+ V P + L
Sbjct: 761 GQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRL 820
Query: 1290 TFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTV 1349
+ T + P G P + L T++ F +
Sbjct: 821 VINHTQMNTALIQWHPPVDTFG-PLQGYRLKFGRKDMEPLTTLEFSEK---EDHFTATDI 876
Query: 1350 KAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQP-----RLTVSKTTSSSITLSWLP--- 1401
S + A N G E ++ ++ +P + P L TTS+S+ LSW P
Sbjct: 877 HKGASYVFRLSARNKVGFGEEMVK-EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVL 935
Query: 1402 GDNGGSSIRGYILQYSEDN-----SEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNG 1456
+ G I Y L Y + N EQ I P++ + L LK T Y + A
Sbjct: 936 AERNGI-ITKYTLLYRDINIPLLPMEQL----IVPADTTMTLTGLKPDTTYDVKVRAHTS 990
Query: 1457 VGPGRISEIIEAKTLGKEPQFSKEQELFASINTT 1490
GPG S ++ +TL + F+K + A + T+
Sbjct: 991 KGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTS 1024
Score = 148 bits (373), Expect = 6e-35
Identities = 242/1060 (22%), Positives = 396/1060 (37%), Gaps = 156/1060 (14%)
Query: 307 RLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGIN 366
R + P + T +P G S C TG ++ W + G+ ++ N R I
Sbjct: 17 RTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVS---NQRFEVIE 73
Query: 367 HEN------LIMDHMVKSDGGAYQCFVRKD--KLSAQDYVQVVLED----GTPKIISAFS 414
++ I D Y+C + ++S + V+ ED G P I
Sbjct: 74 FDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQ 133
Query: 415 EKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEG----NVVSYLN 470
KVV +++C G P P ITW D P+ ++ + + SE + L
Sbjct: 134 LKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQ 193
Query: 471 ISSSQVRDGGVYRCTANNSAGVVLYQARIN--VRGPASIR--------PMKNITAIAGRD 520
I S+ D G Y C A NSAG Y A N VR +R P N + G
Sbjct: 194 IEQSEESDQGKYECVATNSAG-TRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGS 252
Query: 521 TYIHCRVIGYPYYSIKWYKNS-NLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLV 579
I C +G P +KW + +L P + + L+L+DV++ + YTC +
Sbjct: 253 VNITCVAVGSPMPYVKWMLGAEDLTPEDDMPI---GRNVLELNDVRQSAN---YTC--VA 304
Query: 580 QPQLSTSQSV-HVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIP 638
L +++ +TVK P + P V S IT+TW G P P
Sbjct: 305 MSTLGVIEAIAQITVKALP-------------KPPGTPVVTESTATSITLTWD-SGNPEP 350
Query: 639 GS-------------LGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLI 685
S L ID + T+ ++ LS + + +A N ++
Sbjct: 351 VSYYIIQHKPKNSEELYKEIDGV-ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVL 409
Query: 686 VRVPPKFVVQ-PRD-QDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRI 743
+ + PRD Q + IL + WK +P NG+I
Sbjct: 410 TQTSEQAPSSAPRDVQARMLSSTTIL-----------VQWK----------EPEEPNGQI 448
Query: 744 Q---------VLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYP 794
Q + + +KH V + +G V + Y +VK+ A TS
Sbjct: 449 QGYRVYYTMDPTQHVNNWMKHNVADSQ-------ITTIGNLVPQKTY-SVKVLA-FTSIG 499
Query: 795 NTTLATQ----------GQKKEMSCTAHGEKPIIVRW--EKEDRIINPEMARYLVSTKEV 842
+ L++ GQ E I++ W + D I N E+ + E
Sbjct: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYEL---VYKDGEH 556
Query: 843 GEEVISTLQILPTVR------EDSGFFSCHAINSYGEDRGIIQL---TVQEPPD--PPEI 891
GEE T++ + R +F A + G ++ T+Q P P +I
Sbjct: 557 GEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDI 616
Query: 892 EIKDVKARTITLRWTMG--FDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIID 949
+ +I + W N IT Y I+ D + +
Sbjct: 617 SCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQ 676
Query: 950 IHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPK 1009
+ + Y I + A +G S + I +E P GPP++V +E ++S S++V+W++P
Sbjct: 677 LEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPV 736
Query: 1010 KHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNR 1069
+ Q+G IRGYQ+ Y G ++ D++ + L T Y L V A
Sbjct: 737 PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTT 796
Query: 1070 AGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYW 1129
G G S+ + +T VP P + T + I W G LQG+R+ +
Sbjct: 797 KGDGARSKPKLVSTTGAVPGKP--RLVINHTQMNTALIQWH--PPVDTFGPLQGYRLKFG 852
Query: 1130 ANLMDGELGEIKNITTTQPSLELD-----GLEKYTNYSIQVLAFTRAGDGVRSEQIFTRT 1184
+++ +TT + S + D + K +Y ++ A + G G + +
Sbjct: 853 RK-------DMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIP 905
Query: 1185 KEDVPGPPAGVKAAAASASMVFVSWLPPL--KLNGIIRKYT-VFCSHPYPTVISEFEASP 1241
+E G P + + +++ V +SW PP+ + NGII KYT ++ P + E P
Sbjct: 906 EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVP 965
Query: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPL 1281
+ + L + Y V V A TS G G S + L
Sbjct: 966 ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTL 1005
Score = 72.8 bits (177), Expect = 3e-12
Identities = 91/434 (20%), Positives = 175/434 (40%), Gaps = 33/434 (7%)
Query: 805 KEMSCTAHGEKPIIVRW-----EKEDRIINPEMARYLVSTKE-------VGEEVISTLQI 852
+++SCT+ I+V W EK++ II +Y E +G +T +
Sbjct: 614 QDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYL 673
Query: 853 LPTVREDSGF---FSCHAINSYGEDRGIIQLTVQE--PPDPP-EIEIKDVKARTITLRWT 906
L + + + + + H G + + + E P PP ++E++ V + ++ + W
Sbjct: 674 LEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWR 733
Query: 907 MGFDG--NSPITGYDIECKNKSDSWDSAQ-RTKDVS-PQLNSATIIDIHPSSTYSIRMYA 962
+ I GY + + Q KDV I + P ++YS+ + A
Sbjct: 734 SPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTA 793
Query: 963 KNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQI 1022
G S ++ A P P ++ +++ I+ W P G ++GY++
Sbjct: 794 YTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQ--WHPPVDTF--GPLQGYRL 849
Query: 1023 GYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITT 1082
+ G + +++ S + +T +++K Y + A N+ G G + I+
Sbjct: 850 KF-----GRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISI 904
Query: 1083 TLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKN 1142
E+VP+ P+N+ + T+ S+ +SW NGI+ + ++Y ++ L +
Sbjct: 905 P-EEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY-RDINIPLLPMEQL 962
Query: 1143 ITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASA 1202
I ++ L GL+ T Y ++V A T G G S + RT A
Sbjct: 963 IVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMK 1022
Query: 1203 SMVFVSWLPPLKLN 1216
+ V +SW P N
Sbjct: 1023 TSVLLSWEIPENYN 1036
Score = 60.1 bits (144), Expect = 2e-08
Identities = 71/320 (22%), Positives = 123/320 (38%), Gaps = 47/320 (14%)
Query: 216 FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLK-----DNMPLELSGR 270
F+ A + P + ++G C+A G P P W K N E+
Sbjct: 15 FLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEF 74
Query: 271 FQKTVTGLLIENIR-PSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKS-SVG 328
+ + L I+ +R P D Y C SN G V RL V L+ PR + +G
Sbjct: 75 DDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTV---LREDQIPRGFPTIDMG 131
Query: 329 SQV---------SLSCSVTGTEDQELSWYRNG-EILNPGKNVRITGINHEN--------- 369
Q+ ++ C+ +G D E++W+++ + N RI + E+
Sbjct: 132 PQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGA 191
Query: 370 LIMDHMVKSDGGAYQCFVRKD-----KLSAQDYVQVVLE--DGTPKIISAFSEKVVSPAE 422
L ++ +SD G Y+C A YV+ + E P+ + + P
Sbjct: 192 LQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGG 251
Query: 423 PVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVY 482
V++ C G+P+P + W L + + I + + + + VR Y
Sbjct: 252 SVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNV-----------LELNDVRQSANY 300
Query: 483 RCTANNSAGVVLYQARINVR 502
C A ++ GV+ A+I V+
Sbjct: 301 TCVAMSTLGVIEAIAQITVK 320
Score = 58.5 bits (140), Expect = 6e-08
Identities = 66/262 (25%), Positives = 98/262 (37%), Gaps = 38/262 (14%)
Query: 132 DQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLIT-----STGALYIKDV 186
DQ + G VA F C I W K VS RF + S L I+ +
Sbjct: 32 DQTGVSGGVASFICQATGDPRPKIV---WNKKGKK-VSNQRFEVIEFDDGSGSVLRIQPL 87
Query: 187 QNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRVE-LP 245
+ Y C+ + GE S + D +D K + R +
Sbjct: 88 RTPRDEAIYECVASNN-VGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATML 146
Query: 246 CKALGHPEPDYRWLKDNMPLELS---GRFQKTVT----------GLLIENIRPSDSGSYV 292
C A G+P+P+ W KD +P++ S GR ++ + L IE SD G Y
Sbjct: 147 CAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYE 206
Query: 293 CEVSNRYGTA-KVIGRLYVKQ-------PLKATISPRKVKSSVGSQVSLSCSVTGTEDQE 344
C +N GT LYV++ P + +I P + G V+++C G+
Sbjct: 207 CVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPY 266
Query: 345 LSWYRNGEILNP------GKNV 360
+ W E L P G+NV
Sbjct: 267 VKWMLGAEDLTPEDDMPIGRNV 288
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,503,416
Number of Sequences: 37866
Number of extensions: 3862680
Number of successful extensions: 28614
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 280
Number of HSP's successfully gapped in prelim test: 291
Number of HSP's that attempted gapping in prelim test: 10830
Number of HSP's gapped (non-prelim): 6894
length of query: 2012
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1895
effective length of database: 13,817,196
effective search space: 26183586420
effective search space used: 26183586420
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.