BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [Homo sapiens] (881 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 1782 0.0 gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 1782 0.0 gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 1782 0.0 gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 814 0.0 gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 814 0.0 gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 379 e-105 gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 262 1e-69 gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 155 2e-37 gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 146 7e-35 gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchan... 126 8e-29 gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 107 5e-23 gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 107 5e-23 gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 87 9e-17 gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 87 9e-17 gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 84 8e-16 gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 83 1e-15 gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 83 1e-15 gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 83 1e-15 gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 82 3e-15 gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 79 1e-14 gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 79 1e-14 gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 79 1e-14 gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 79 2e-14 gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 79 2e-14 gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 78 3e-14 gi|15529996 son of sevenless homolog 1 [Homo sapiens] 72 2e-12 gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 70 7e-12 gi|154689780 son of sevenless homolog 2 [Homo sapiens] 70 9e-12 gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 67 7e-11 gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 67 7e-11 >gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b [Homo sapiens] Length = 881 Score = 1782 bits (4615), Expect = 0.0 Identities = 881/881 (100%), Positives = 881/881 (100%) Query: 1 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR 60 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR Sbjct: 1 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR 60 Query: 61 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE 120 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE Sbjct: 61 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE 120 Query: 121 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR 180 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR Sbjct: 121 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR 180 Query: 181 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS 240 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS Sbjct: 181 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS 240 Query: 241 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF Sbjct: 241 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300 Query: 301 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE 360 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE Sbjct: 301 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE 360 Query: 361 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR 420 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR Sbjct: 361 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR 420 Query: 421 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN 480 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN Sbjct: 421 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN 480 Query: 481 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV 540 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV Sbjct: 481 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV 540 Query: 541 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI 600 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI Sbjct: 541 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI 600 Query: 601 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA 660 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA Sbjct: 601 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA 660 Query: 661 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS 720 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS Sbjct: 661 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS 720 Query: 721 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 780 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM Sbjct: 721 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 780 Query: 781 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI 840 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI Sbjct: 781 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI 840 Query: 841 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 881 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP Sbjct: 841 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 881 >gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [Homo sapiens] Length = 881 Score = 1782 bits (4615), Expect = 0.0 Identities = 881/881 (100%), Positives = 881/881 (100%) Query: 1 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR 60 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR Sbjct: 1 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR 60 Query: 61 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE 120 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE Sbjct: 61 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE 120 Query: 121 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR 180 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR Sbjct: 121 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR 180 Query: 181 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS 240 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS Sbjct: 181 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS 240 Query: 241 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF Sbjct: 241 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300 Query: 301 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE 360 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE Sbjct: 301 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE 360 Query: 361 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR 420 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR Sbjct: 361 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR 420 Query: 421 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN 480 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN Sbjct: 421 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN 480 Query: 481 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV 540 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV Sbjct: 481 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV 540 Query: 541 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI 600 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI Sbjct: 541 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI 600 Query: 601 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA 660 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA Sbjct: 601 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA 660 Query: 661 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS 720 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS Sbjct: 661 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS 720 Query: 721 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 780 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM Sbjct: 721 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 780 Query: 781 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI 840 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI Sbjct: 781 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI 840 Query: 841 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 881 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP Sbjct: 841 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 881 >gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a [Homo sapiens] Length = 923 Score = 1782 bits (4615), Expect = 0.0 Identities = 881/881 (100%), Positives = 881/881 (100%) Query: 1 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR 60 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR Sbjct: 43 MVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGR 102 Query: 61 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE 120 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE Sbjct: 103 QLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE 162 Query: 121 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR 180 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR Sbjct: 163 GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALR 222 Query: 181 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS 240 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS Sbjct: 223 KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS 282 Query: 241 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 300 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF Sbjct: 283 WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF 342 Query: 301 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE 360 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE Sbjct: 343 NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE 402 Query: 361 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR 420 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR Sbjct: 403 AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKR 462 Query: 421 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN 480 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN Sbjct: 463 QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLEN 522 Query: 481 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV 540 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV Sbjct: 523 GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASV 582 Query: 541 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI 600 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI Sbjct: 583 REVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELI 642 Query: 601 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA 660 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA Sbjct: 643 PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTA 702 Query: 661 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS 720 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS Sbjct: 703 NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLS 762 Query: 721 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 780 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM Sbjct: 763 NSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 822 Query: 781 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI 840 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI Sbjct: 823 TFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARI 882 Query: 841 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 881 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP Sbjct: 883 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 923 >gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform b [Homo sapiens] Length = 867 Score = 814 bits (2102), Expect = 0.0 Identities = 431/861 (50%), Positives = 593/861 (68%), Gaps = 43/861 (4%) Query: 32 TPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGR 91 TPL L + ++ + +E++LRAG+ L +L+ P++IRDRKYHL+ YRQCC G Sbjct: 36 TPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGT 95 Query: 92 ELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPE--P 149 ELVD ++ VHSR+Q VG+ QVLL++G L HV + FQD+ FYRF E E P Sbjct: 96 ELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL-FYRFLDDEHEDAP 154 Query: 150 VGTHE----MEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVA 205 + T E +EEL + + LLSQ GPDA + + LRKPPGQRT ++L++I+EELLHIKA++ Sbjct: 155 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 214 Query: 206 HLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEG 265 HLS +VKRELA VL+FE H+K GTVLF+QG++GTSWYII KGSVNVV +GKG+V TLHEG Sbjct: 215 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 274 Query: 266 DDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLE 325 DDFG+LALVNDAPRAA+I+LREDNCHFLRVDK+DFNRI++DVEA T+RL+EH + VLVLE Sbjct: 275 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 334 Query: 326 RASQG-----AGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFL 380 + G G S+P + +YTVMSGTPEKILE LE + +++ ++ T++ L+DF+ Sbjct: 335 KVPAGNRASNQGNSQP----QQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFI 390 Query: 381 LTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHT 440 + H VFMP+ QLC AL+ H+H +P+ G+EQE+ Y N +++++RLV QW A+YG +L Sbjct: 391 MMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQE 450 Query: 441 DPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPN 500 D V+ +FL++ V D R+ L+EQ PE + + + A PQ K + L Sbjct: 451 DDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKA-PQKKHKVLLQQFNT 509 Query: 501 QDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLV 560 DE I+ D+V + + DH+ T+++PV SV+EV++A+A + G +G ++V Sbjct: 510 GDERAQKRQ-PIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV 568 Query: 561 KVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVS 620 K++S G+ + L+P+ V T+L +N RLF ++ L P P+Q GPTVG+ +L+S Sbjct: 569 KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMS 628 Query: 621 AKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATEL 680 +KDLA Q+T +DW LFN +H++ELI++ G +H TTANL+ F+RRFNE+Q+WV TE+ Sbjct: 629 SKDLAYQMTIYDWELFNCVHELELIYHTFG-RHNFKKTTANLDLFLRRFNEIQFWVVTEI 687 Query: 681 CLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRK 740 CLC R QLL+KFIK+AAH KE KNLNSFFA++ GLSN A+SRLA TWE+LP K +K Sbjct: 688 CLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKK 747 Query: 741 LYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKM 800 Y+ E L+DPS NHR YRL +AKL PP+IPFMPLL+KDMTF HEGN T ++NL+NFEKM Sbjct: 748 FYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKM 807 Query: 801 RMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYV 860 RM+A AR + + RS P +P ++ + H+D + +YV Sbjct: 808 RMIANTARTVRYYRSQ---PFNPDAAQANKNHQDVR---------------------SYV 843 Query: 861 QQLKVIDNQRELSRLSRELEP 881 +QL VIDNQR LS++S LEP Sbjct: 844 RQLNVIDNQRTLSQMSHRLEP 864 >gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a [Homo sapiens] Length = 1011 Score = 814 bits (2102), Expect = 0.0 Identities = 431/861 (50%), Positives = 593/861 (68%), Gaps = 43/861 (4%) Query: 32 TPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGR 91 TPL L + ++ + +E++LRAG+ L +L+ P++IRDRKYHL+ YRQCC G Sbjct: 180 TPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGT 239 Query: 92 ELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPE--P 149 ELVD ++ VHSR+Q VG+ QVLL++G L HV + FQD+ FYRF E E P Sbjct: 240 ELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYL-FYRFLDDEHEDAP 298 Query: 150 VGTHE----MEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVA 205 + T E +EEL + + LLSQ GPDA + + LRKPPGQRT ++L++I+EELLHIKA++ Sbjct: 299 LPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALS 358 Query: 206 HLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEG 265 HLS +VKRELA VL+FE H+K GTVLF+QG++GTSWYII KGSVNVV +GKG+V TLHEG Sbjct: 359 HLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEG 418 Query: 266 DDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLE 325 DDFG+LALVNDAPRAA+I+LREDNCHFLRVDK+DFNRI++DVEA T+RL+EH + VLVLE Sbjct: 419 DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLE 478 Query: 326 RASQG-----AGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFL 380 + G G S+P + +YTVMSGTPEKILE LE + +++ ++ T++ L+DF+ Sbjct: 479 KVPAGNRASNQGNSQP----QQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFI 534 Query: 381 LTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHT 440 + H VFMP+ QLC AL+ H+H +P+ G+EQE+ Y N +++++RLV QW A+YG +L Sbjct: 535 MMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQE 594 Query: 441 DPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPN 500 D V+ +FL++ V D R+ L+EQ PE + + + A PQ K + L Sbjct: 595 DDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKA-PQKKHKVLLQQFNT 653 Query: 501 QDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLV 560 DE I+ D+V + + DH+ T+++PV SV+EV++A+A + G +G ++V Sbjct: 654 GDERAQKRQ-PIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV 712 Query: 561 KVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVS 620 K++S G+ + L+P+ V T+L +N RLF ++ L P P+Q GPTVG+ +L+S Sbjct: 713 KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMS 772 Query: 621 AKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATEL 680 +KDLA Q+T +DW LFN +H++ELI++ G +H TTANL+ F+RRFNE+Q+WV TE+ Sbjct: 773 SKDLAYQMTIYDWELFNCVHELELIYHTFG-RHNFKKTTANLDLFLRRFNEIQFWVVTEI 831 Query: 681 CLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRK 740 CLC R QLL+KFIK+AAH KE KNLNSFFA++ GLSN A+SRLA TWE+LP K +K Sbjct: 832 CLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKK 891 Query: 741 LYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKM 800 Y+ E L+DPS NHR YRL +AKL PP+IPFMPLL+KDMTF HEGN T ++NL+NFEKM Sbjct: 892 FYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKM 951 Query: 801 RMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYV 860 RM+A AR + + RS P +P ++ + H+D + +YV Sbjct: 952 RMIANTARTVRYYRSQ---PFNPDAAQANKNHQDVR---------------------SYV 987 Query: 861 QQLKVIDNQRELSRLSRELEP 881 +QL VIDNQR LS++S LEP Sbjct: 988 RQLNVIDNQRTLSQMSHRLEP 1008 Score = 67.0 bits (162), Expect = 7e-11 Identities = 43/131 (32%), Positives = 74/131 (56%), Gaps = 9/131 (6%) Query: 179 LRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKG 238 L K P +R+ E++D+IF L +KA ++ ++ +E K G LF QGD G Sbjct: 19 LDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEK-GITLFRQGDIG 77 Query: 239 TSWYIIWKGSVNV-----VTHGKGL-VTTLHEGDDFGQLALVNDAPRAATIILREDNCHF 292 T+WY + GS++V +H + + TL G FG+ +++++ PR ATI+ RE + Sbjct: 78 TNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGE-SILDNTPRHATIVTRESS-EL 135 Query: 293 LRVDKQDFNRI 303 LR++++DF + Sbjct: 136 LRIEQKDFKAL 146 >gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo sapiens] Length = 730 Score = 379 bits (973), Expect = e-105 Identities = 269/781 (34%), Positives = 415/781 (53%), Gaps = 65/781 (8%) Query: 111 VGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTH-EMEEELAEAVALLSQR 169 +G+ Q+LLD G + V FQD FY+F E + E EEE V LL Q Sbjct: 3 IGVWQLLLDMGIMLSVDQHLYFQDTYV-FYQFSSDECSYLYCEFEREEEWQNGVKLLLQL 61 Query: 170 GPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGT 229 P + + Q+ ++ + E L+ L+++V+RELAAV+ + A Sbjct: 62 VPLIPARGGICELSHQKIEDSEESSDEILVR------LTSAVQRELAAVIALKARKSA-- 113 Query: 230 VLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDN 289 Q ++ ++ + +V G++ L E D+ G++ LV L ++N Sbjct: 114 --IEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQK--------LAKEN 163 Query: 290 CHFLRVDKQDFNRII-KDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRN----RY 344 FL+ DK++ + +D E T++++E + VLVL++ Q GP+ PT G RY Sbjct: 164 YQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKV-QCCGPA--PTAGSAESHWRY 220 Query: 345 TVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEP 404 V+SGTPEKILE LL + + TET L DFLLT+ VFM + LC ALL H+ + Sbjct: 221 VVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKK 280 Query: 405 AGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNL 464 G E+ V +++++L LVSQW+ALY L D + FL+ + V D + Sbjct: 281 YQGKEENSD--VPRRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPI 338 Query: 465 LREQWPERRRC---HRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYD 521 L ++ E ++ HR + SPQ K + L ++ L + +++ Sbjct: 339 LEKELKEFQKILGMHR-RHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTET-EEIFCH 396 Query: 522 ICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV-LVKVNSAGDAIGLQPDARGVAT 580 + +HS ++++ V++ +E++ +A++ + + + LV + +G+ LQP+ ++ Sbjct: 397 VYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISK 456 Query: 581 SLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIH 640 SL + R++V L P + S L + + DLA +L + DWSLFNSIH Sbjct: 457 SLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGM-NTWDLALELMNFDWSLFNSIH 515 Query: 641 QVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLA 700 + ELI++ Q + TANL ++R NE+Q WVATE+ LC G R QL++KFIK+A Sbjct: 516 EQELIYFTFSRQGSGE-HTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIA 574 Query: 701 AHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRL 760 AH K Q+NLNSFFA++ GL+ +++SRL+ TWE++P K +KL+S LE L DPS NH+ YR Sbjct: 575 AHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRD 634 Query: 761 ALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVP 820 A K+ PP IPFMPLLLKD+TFIHEGN T ++NL+NFEK+ M+A R L HCR++ Sbjct: 635 AFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGD 694 Query: 821 LSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELE 880 LSP H++ + +YV L VID+Q+ L LS +E Sbjct: 695 LSPKE------HQELK---------------------SYVNHLYVIDSQQALFELSHRIE 727 Query: 881 P 881 P Sbjct: 728 P 728 >gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [Homo sapiens] Length = 456 Score = 262 bits (669), Expect = 1e-69 Identities = 166/475 (34%), Positives = 259/475 (54%), Gaps = 44/475 (9%) Query: 419 KRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRL 478 ++Q L ++ ++ Y +L + A ++ L L+ +D L LRE + R H+L Sbjct: 9 RKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLRE---DTLRLHQL 65 Query: 479 ENGCG------NASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTL 532 N P + + L D L + A + D++ + PDHS +T+ Sbjct: 66 VETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQ-TRVAFRGSDEIFCRVYMPDHSYVTI 124 Query: 533 QLPVTASVREVMAALAQE-------DGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLN 585 + ++ASV++++ ++ ++ G +LV V+S+G+ + LQP V T+LG+N Sbjct: 125 RSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGIN 184 Query: 586 ERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELI 645 LF L+P P+++ + G E + V +D+A LT W LF +H++E + Sbjct: 185 SHLFACTRDSYEALVPLPEEIQVSPGDTE-IHRVEPEDVANHLTAFHWELFRCVHELEFV 243 Query: 646 HYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKE 705 YV + R TANLE ++R +E+ +WVATE+ LC PG RAQLL+KFIK+AA K+ Sbjct: 244 DYVFHGERGRR-ETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQ 302 Query: 706 QKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKL 765 ++L SF+AV+ GL N+A+SRL TWE+LP K + L+ E L DP NH+ YR ++K+ Sbjct: 303 NQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKM 362 Query: 766 SPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLR 825 PPVIPF+PL+LKD+TF+HEG+ TLV+ L+N EK+ +A R + RS P+ L + Sbjct: 363 KPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSR-PLCLD-ME 420 Query: 826 SRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELE 880 + +HL T AYV+Q +VIDNQ L LS +LE Sbjct: 421 ASPNHLQ-----------------------TKAYVRQFQVIDNQNLLFELSYKLE 452 >gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] Length = 1499 Score = 155 bits (392), Expect = 2e-37 Identities = 103/295 (34%), Positives = 156/295 (52%), Gaps = 7/295 (2%) Query: 536 VTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQE 595 V ++RE A A D ++ +V V L +A + L+ R ++ N E Sbjct: 634 VIQAIRE-FAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNME 692 Query: 596 VHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR 655 L D S L +S ++A QL+ ++ LF +I E I + LR Sbjct: 693 TETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF---KLR 749 Query: 656 DVTT-ANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFA 714 T+ ANL+RF N+ +WVA+E+ R ++++ FIK+A H +E KN NS FA Sbjct: 750 SKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFA 809 Query: 715 VMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL--AKLSPPVIPF 772 ++ GL+ + ++RL TWE+LP+K KL+ L+ L DPS N YR L L PP+IP Sbjct: 810 IISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPL 869 Query: 773 MPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSR 827 P++ KD+TF+HEGN + V+ L+NFEK+RM+A+ R + S N P R+R Sbjct: 870 FPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTR 924 Score = 126 bits (317), Expect = 8e-29 Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 43/351 (12%) Query: 156 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKREL 215 EE++ A L R ++ L K P RTD++++ + E + + A A+++ SV+REL Sbjct: 91 EEDIERASDPLMSRD---IVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRREL 147 Query: 216 AAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVN 275 AV++F +AGT++ + G++ SW +I GSV VT+ G L G+ FG ++ Sbjct: 148 CAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVE-VTYPDGKAEILCMGNSFGVSPTMD 206 Query: 276 DAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSR 335 + + D+C F+ + +QD+ RI+ VE ++EE G++V+V E Sbjct: 207 KEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDR---- 262 Query: 336 PPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAA 395 T R + V+ GT E++ L+E + S DP TF+ DFLLT+R F+ S Sbjct: 263 --TGTRKGHIVIKGTSERLTMHLVE----EHSVVDP--TFIEDFLLTYRTFLSSPMEVGK 314 Query: 396 LLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLV 455 L + +P + R ++ R+V WV + + DP T FL++ Sbjct: 315 KLLEWFNDP-------------SLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE--- 358 Query: 456 GRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLP 506 +NL RE+ R L C + + K R + + P+++ PLP Sbjct: 359 ------NNLEREKMGGHLRL--LNIAC---AAKAKRRLMTLTKPSREAPLP 398 >gi|54633319 PDZ domain-containing guanine nucleotide exchange factor I [Homo sapiens] Length = 1601 Score = 146 bits (369), Expect = 7e-35 Identities = 89/253 (35%), Positives = 137/253 (54%), Gaps = 6/253 (2%) Query: 578 VATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFN 637 +A + LN R ++ N E L D S + +S ++A QL+ D+ LF Sbjct: 818 LADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFR 877 Query: 638 SIHQVELIHYVLGPQHLRDVT-TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKF 696 +I E I + L T +L+RF N+ +WVA+E+ R ++++ F Sbjct: 878 NIEPTEYIDDLF---KLNSKTGNTHLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHF 934 Query: 697 IKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHR 756 IK+A H +E KN NS FA++ GL+ ++++RL TWE+LP K K L+ + DPS N Sbjct: 935 IKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMA 994 Query: 757 VYR--LALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCR 814 YR L+ + PP+IP P++ KDMTF+HEGN + V+ L+NFEK+RM+++ R + Sbjct: 995 KYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMT 1054 Query: 815 SHNPVPLSPLRSR 827 S N P R R Sbjct: 1055 SANMDPAMMFRQR 1067 Score = 134 bits (337), Expect = 4e-31 Identities = 100/356 (28%), Positives = 174/356 (48%), Gaps = 35/356 (9%) Query: 114 CQVLLDEGA--LCHVKHDWAFQDRDAQFYRFPGPEPEPVGTHEMEEELAEAVALLSQRGP 171 C + D G+ L + + D R P PV + + EEE E +G Sbjct: 193 CSIASDSGSSSLSDIYQATESEVGDVDLTRLP---EGPVDSEDDEEEDEEIDRTDPLQGR 249 Query: 172 DALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVL 231 D L+ L K P +TD++++ + E + + A A+++ SV+REL +V++FE +AG ++ Sbjct: 250 D-LVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAII 308 Query: 232 FSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCH 291 G + SWY+I G+V ++H G V L G+ FG ++ + + D+C Sbjct: 309 LEDGQELDSWYVILNGTVE-ISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQ 367 Query: 292 FLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTP 351 F+ + +QD+ RI+ VE T ++EE G++V+V E + R + V+ TP Sbjct: 368 FVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGT------RKGHIVIKATP 421 Query: 352 EKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPS-AQLCAALLHHFHVEPAGGSEQ 410 E+++ L+E + S DP T++ DFLLT+R F+ S + LL F ++ Sbjct: 422 ERLIMHLIE----EHSIVDP--TYIEDFLLTYRTFLESPLDVGIKLLEWFKID------- 468 Query: 411 ERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLR 466 + R ++ R+V WV + + DP T FL++ + DT+++ LR Sbjct: 469 -------SLRDKVTRIVLLWVNNHFNDFEGDPAMTRFLEEFEKNL-EDTKMNGHLR 516 Score = 41.2 bits (95), Expect = 0.004 Identities = 29/92 (31%), Positives = 46/92 (50%), Gaps = 3/92 (3%) Query: 178 ALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDK 237 ALRK P +RT E+L+ I+ L ++ +++L R ++A +E +S VLF Sbjct: 12 ALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYS-GNQVLFCSETI 70 Query: 238 GTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFG 269 WYI+ GS V+ G ++ G FG Sbjct: 71 ARCWYILLSGS--VLVKGSMVLPPCSFGKQFG 100 >gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchange factor 2, partial [Homo sapiens] Length = 803 Score = 126 bits (317), Expect = 8e-29 Identities = 100/351 (28%), Positives = 169/351 (48%), Gaps = 43/351 (12%) Query: 156 EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKREL 215 EE++ A L R ++ L K P RTD++++ + E + + A A+++ SV+REL Sbjct: 91 EEDIERASDPLMSRD---IVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRREL 147 Query: 216 AAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVN 275 AV++F +AGT++ + G++ SW +I GSV VT+ G L G+ FG ++ Sbjct: 148 CAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVE-VTYPDGKAEILCMGNSFGVSPTMD 206 Query: 276 DAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSR 335 + + D+C F+ + +QD+ RI+ VE ++EE G++V+V E Sbjct: 207 KEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDR---- 262 Query: 336 PPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAA 395 T R + V+ GT E++ L+E + S DP TF+ DFLLT+R F+ S Sbjct: 263 --TGTRKGHIVIKGTSERLTMHLVE----EHSVVDP--TFIEDFLLTYRTFLSSPMEVGK 314 Query: 396 LLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLV 455 L + +P + R ++ R+V WV + + DP T FL++ Sbjct: 315 KLLEWFNDP-------------SLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE--- 358 Query: 456 GRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLP 506 +NL RE+ R L C + + K R + + P+++ PLP Sbjct: 359 ------NNLEREKMGGHLRL--LNIAC---AAKAKRRLMTLTKPSREAPLP 398 Score = 52.8 bits (125), Expect = 1e-06 Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 5/174 (2%) Query: 536 VTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQE 595 V ++RE A A D ++ +V V L +A + L+ R ++ N E Sbjct: 634 VIQAIRE-FAVTATPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNME 692 Query: 596 VHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR 655 L D S L +S ++A QL+ ++ LF +I E I + LR Sbjct: 693 TETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF---KLR 749 Query: 656 DVTT-ANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKN 708 T+ ANL+RF N+ +WVA+E+ R ++++ FIK+A H +E KN Sbjct: 750 SKTSCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKN 803 >gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo sapiens] Length = 1095 Score = 107 bits (267), Expect = 5e-23 Identities = 60/177 (33%), Positives = 100/177 (56%), Gaps = 8/177 (4%) Query: 623 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 682 ++A QLT D LF +++E+ +L + + + NL +F FN + YWV + + L Sbjct: 861 EIAEQLTLLDAELF---YKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIML 917 Query: 683 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 742 R +LL KFIK+ HL++ N NS+ A++ L ++ I RL W++ + Y Sbjct: 918 QEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EWQKQTSEGLAEY 975 Query: 743 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEK 799 L+D S + R YR AL+++ PP IP++ L+L+D+TF+H GN ++ +NF K Sbjct: 976 CT---LIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1029 >gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo sapiens] Length = 1077 Score = 107 bits (267), Expect = 5e-23 Identities = 60/177 (33%), Positives = 100/177 (56%), Gaps = 8/177 (4%) Query: 623 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 682 ++A QLT D LF +++E+ +L + + + NL +F FN + YWV + + L Sbjct: 843 EIAEQLTLLDAELF---YKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIML 899 Query: 683 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 742 R +LL KFIK+ HL++ N NS+ A++ L ++ I RL W++ + Y Sbjct: 900 QEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL--EWQKQTSEGLAEY 957 Query: 743 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEK 799 L+D S + R YR AL+++ PP IP++ L+L+D+TF+H GN ++ +NF K Sbjct: 958 CT---LIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSK 1011 >gi|22749129 RasGEF domain family, member 1B [Homo sapiens] Length = 473 Score = 86.7 bits (213), Expect = 9e-17 Identities = 58/159 (36%), Positives = 84/159 (52%), Gaps = 15/159 (9%) Query: 659 TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFG 718 T NLE ++ FN L Y VATE+C+ RA+++ FI +A N NS A++ G Sbjct: 252 TRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISG 311 Query: 719 LSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSP 767 ++ S +SRL TW ++ K K + LE +DPS N YR AL + Sbjct: 312 MNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREK 368 Query: 768 PVIPFMPLLLKDMTFIHEG-NHTLVENLINFEKMRMMAR 805 VIPF LL+KD+ F++EG + L +NFEK +A+ Sbjct: 369 IVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAK 407 Score = 30.8 bits (68), Expect = 5.8 Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 3/81 (3%) Query: 355 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERST 414 LE L++ + P+ + P T++ FLL+ R+FM +L A + H VE S+ + Sbjct: 43 LEALIQHLVPNVDYY-PDRTYIFTFLLSSRLFMHPYELMAKVC-HLCVEHQRLSDPDSDK 100 Query: 415 YVCNK-RQQILRLVSQWVALY 434 K +IL+L+++W + Sbjct: 101 NQMRKIAPKILQLLTEWTETF 121 >gi|40255197 RasGEF domain family, member 1C [Homo sapiens] Length = 466 Score = 86.7 bits (213), Expect = 9e-17 Identities = 57/159 (35%), Positives = 86/159 (54%), Gaps = 15/159 (9%) Query: 659 TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFG 718 T+NLE +++ FN L Y VATE+C+ RAQ++ FI +A N NS A++ G Sbjct: 245 TSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISG 304 Query: 719 LSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSP 767 ++ S +SRL TW ++ + K + LE +DP+ N YR AL + Sbjct: 305 MNMSPVSRLKKTWAKV--RTAKFF-ILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREK 361 Query: 768 PVIPFMPLLLKDMTFIHEG-NHTLVENLINFEKMRMMAR 805 VIPF LL+KD+ F++EG + L +NFEK +A+ Sbjct: 362 IVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAK 400 Score = 32.7 bits (73), Expect = 1.5 Identities = 33/133 (24%), Positives = 62/133 (46%), Gaps = 19/133 (14%) Query: 333 PSRPPTPGRNR-YTVMSGTPEKI-LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSA 390 P PT G ++ G P LE L++ + P + + P + ++ FLL+ R+F+ Sbjct: 19 PPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYY-PEKAYIFTFLLSSRLFIEPR 77 Query: 391 QLCAALLHHFHVEPAGGSEQERSTYVCNKRQ------QILRLVSQWVALYGSMLHTDPVA 444 +L A + H +E +Q+ V +K + ++L+L+++W + D Sbjct: 78 ELLARVC-HLCIE-----QQQLDKPVLDKARVRKFGPKLLQLLAEWTETF----PRDFQE 127 Query: 445 TSFLQKLSDLVGR 457 S + L D+VGR Sbjct: 128 ESTIGHLKDVVGR 140 >gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo sapiens] Length = 583 Score = 83.6 bits (205), Expect = 8e-16 Identities = 56/193 (29%), Positives = 95/193 (49%), Gaps = 2/193 (1%) Query: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 678 V+ ++ AGQ+T D +F +I EL + + + N F RRFN + +WV Sbjct: 48 VTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKE-KYSSAPNAVAFTRRFNHVSFWVVR 106 Query: 679 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 738 E+ RA++L +IK A L E NL++ AV+ GL ++ I RL TW L K Sbjct: 107 EILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKD 166 Query: 739 RKLYSALERLLDPSWNHRVYRLALAKLS-PPVIPFMPLLLKDMTFIHEGNHTLVENLINF 797 + + LE ++ N++ R ++ L P IP++ + L D+T+I + L N Sbjct: 167 KTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILENE 226 Query: 798 EKMRMMARAARML 810 ++ +M R++ Sbjct: 227 QRSNLMNNILRII 239 >gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-regulated) isoform 1 [Homo sapiens] Length = 690 Score = 82.8 bits (203), Expect = 1e-15 Identities = 69/241 (28%), Positives = 108/241 (44%), Gaps = 12/241 (4%) Query: 623 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 682 +LA LT + F I + YV+ H LER + FN + WV + Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVI---HGCLENNPTLERSIALFNGISKWVQLMVLS 211 Query: 683 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 742 P P RA+++ KFI +A L + KN N+ AV+ GLS+S+ISRL T L +V K + Sbjct: 212 KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNW 271 Query: 743 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHE-GNHTLVENLINFEKMR 801 + + L+ + N+ YR A A IP + + LKD+ +H EN +N KM Sbjct: 272 NEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMH 331 Query: 802 MMARAARML-------HHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPA 854 ++ L HH + + ++ L + H + + ++S E S P Sbjct: 332 QLSVTLSELVSLQNASHHLEPNMDL-INLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPT 390 Query: 855 S 855 S Sbjct: 391 S 391 >gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regulated) isoform 1 [Homo sapiens] Length = 690 Score = 82.8 bits (203), Expect = 1e-15 Identities = 69/241 (28%), Positives = 108/241 (44%), Gaps = 12/241 (4%) Query: 623 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 682 +LA LT + F I + YV+ H LER + FN + WV + Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVI---HGCLENNPTLERSIALFNGISKWVQLMVLS 211 Query: 683 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 742 P P RA+++ KFI +A L + KN N+ AV+ GLS+S+ISRL T L +V K + Sbjct: 212 KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNW 271 Query: 743 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHE-GNHTLVENLINFEKMR 801 + + L+ + N+ YR A A IP + + LKD+ +H EN +N KM Sbjct: 272 NEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMH 331 Query: 802 MMARAARML-------HHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPA 854 ++ L HH + + ++ L + H + + ++S E S P Sbjct: 332 QLSVTLSELVSLQNASHHLEPNMDL-INLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPT 390 Query: 855 S 855 S Sbjct: 391 S 391 >gi|38505170 Ras protein-specific guanine nucleotide-releasing factor 2 [Homo sapiens] Length = 1237 Score = 82.8 bits (203), Expect = 1e-15 Identities = 56/198 (28%), Positives = 96/198 (48%), Gaps = 4/198 (2%) Query: 613 AEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL-RDVTTANLERFMRRFNE 671 AE + +SA +LA Q+T D +F SI E + G L ++ T + + + FN+ Sbjct: 995 AECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQ--GWMKLDKNERTPYIMKTSQHFND 1052 Query: 672 LQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTW 731 + VA+++ RA + K++ +A + N N + L+ SAI RL TW Sbjct: 1053 MSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTW 1112 Query: 732 ERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLV 791 ++ + + L L++ + + R L +PP +P++ + L D+ FI EG Sbjct: 1113 AKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFT 1172 Query: 792 -ENLINFEKMRMMARAAR 808 E L+NF KMRM++ R Sbjct: 1173 EEGLVNFSKMRMISHIIR 1190 >gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regulated) isoform 2 [Homo sapiens] Length = 689 Score = 81.6 bits (200), Expect = 3e-15 Identities = 69/241 (28%), Positives = 111/241 (46%), Gaps = 13/241 (5%) Query: 623 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 682 +LA LT + F I + YV+ H LER + FN + WV + Sbjct: 155 ELAEHLTFLEHKSFRRISFTDYQSYVI---HGCLENNPTLERSIALFNGISKWVQLMVLS 211 Query: 683 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 742 P P RA+++ KFI +A L + KN N+ AV+ GLS+S+ISRL T L +V K + Sbjct: 212 KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNW 271 Query: 743 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHE-GNHTLVENLINFEKMR 801 + + L+ + N+ YR A A IP + + LKD+ +H EN +N KM Sbjct: 272 NEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMH 331 Query: 802 MMARAARML-------HHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPA 854 ++ L HH + + ++ L + H + + ++S E +++SP Sbjct: 332 QLSVTLSELVSLQNASHHLEPNMDL-INLLTLSLDLYHTEDDIYKLSLVLEPR-NSKSPT 389 Query: 855 S 855 S Sbjct: 390 S 390 >gi|224586880 Ras protein-specific guanine nucleotide-releasing factor 1 isoform 3 [Homo sapiens] Length = 1257 Score = 79.3 bits (194), Expect = 1e-14 Identities = 55/198 (27%), Positives = 96/198 (48%), Gaps = 4/198 (2%) Query: 613 AEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL-RDVTTANLERFMRRFNE 671 AE + SA ++A QLT D +F I E + G L ++ T + + + FN+ Sbjct: 1015 AEPFENHSALEIAEQLTLLDHLVFKKIPYEEF--FGQGWMKLEKNERTPYIMKTTKHFND 1072 Query: 672 LQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTW 731 + +A+E+ R + K++ +A + N N+ + ++ SAI RL TW Sbjct: 1073 ISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTW 1132 Query: 732 ERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLV 791 ++ + + L L++L+ + R AL PP +P++ + L D+ FI EG Sbjct: 1133 LKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYT 1192 Query: 792 EN-LINFEKMRMMARAAR 808 E+ L+NF KMRM++ R Sbjct: 1193 EDGLVNFSKMRMISHIIR 1210 >gi|24797099 Ras protein-specific guanine nucleotide-releasing factor 1 isoform 1 [Homo sapiens] Length = 1273 Score = 79.3 bits (194), Expect = 1e-14 Identities = 55/198 (27%), Positives = 96/198 (48%), Gaps = 4/198 (2%) Query: 613 AEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL-RDVTTANLERFMRRFNE 671 AE + SA ++A QLT D +F I E + G L ++ T + + + FN+ Sbjct: 1031 AEPFENHSALEIAEQLTLLDHLVFKKIPYEEF--FGQGWMKLEKNERTPYIMKTTKHFND 1088 Query: 672 LQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTW 731 + +A+E+ R + K++ +A + N N+ + ++ SAI RL TW Sbjct: 1089 ISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTW 1148 Query: 732 ERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLV 791 ++ + + L L++L+ + R AL PP +P++ + L D+ FI EG Sbjct: 1149 LKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYT 1208 Query: 792 EN-LINFEKMRMMARAAR 808 E+ L+NF KMRM++ R Sbjct: 1209 EDGLVNFSKMRMISHIIR 1226 >gi|24797101 Ras protein-specific guanine nucleotide-releasing factor 1 isoform 2 [Homo sapiens] Length = 489 Score = 79.3 bits (194), Expect = 1e-14 Identities = 55/198 (27%), Positives = 96/198 (48%), Gaps = 4/198 (2%) Query: 613 AEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHL-RDVTTANLERFMRRFNE 671 AE + SA ++A QLT D +F I E + G L ++ T + + + FN+ Sbjct: 247 AEPFENHSALEIAEQLTLLDHLVFKKIPYEEF--FGQGWMKLEKNERTPYIMKTTKHFND 304 Query: 672 LQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTW 731 + +A+E+ R + K++ +A + N N+ + ++ SAI RL TW Sbjct: 305 ISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTW 364 Query: 732 ERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLV 791 ++ + + L L++L+ + R AL PP +P++ + L D+ FI EG Sbjct: 365 LKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYT 424 Query: 792 EN-LINFEKMRMMARAAR 808 E+ L+NF KMRM++ R Sbjct: 425 EDGLVNFSKMRMISHIIR 442 >gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapiens] Length = 762 Score = 78.6 bits (192), Expect = 2e-14 Identities = 53/185 (28%), Positives = 95/185 (51%), Gaps = 4/185 (2%) Query: 617 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 676 D + ++L+ LT ++ F I + +Y++ + T +ER + N + WV Sbjct: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPT---MERSIALCNGISQWV 258 Query: 677 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 736 + P P RA++ KFI++A L + +N N+ AV+ GL +S+ISRL T +PH Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318 Query: 737 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVEN-LI 795 ++ K+ + LL S N+ YR A + + IP + + LKD+ ++E +E+ + Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378 Query: 796 NFEKM 800 N K+ Sbjct: 379 NVHKL 383 >gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapiens] Length = 797 Score = 78.6 bits (192), Expect = 2e-14 Identities = 53/185 (28%), Positives = 95/185 (51%), Gaps = 4/185 (2%) Query: 617 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 676 D + ++L+ LT ++ F I + +Y++ + T +ER + N + WV Sbjct: 202 DHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPT---MERSIALCNGISQWV 258 Query: 677 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 736 + P P RA++ KFI++A L + +N N+ AV+ GL +S+ISRL T +PH Sbjct: 259 QLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPH 318 Query: 737 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVEN-LI 795 ++ K+ + LL S N+ YR A + + IP + + LKD+ ++E +E+ + Sbjct: 319 EINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKV 378 Query: 796 NFEKM 800 N K+ Sbjct: 379 NVHKL 383 >gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo sapiens] Length = 557 Score = 78.2 bits (191), Expect = 3e-14 Identities = 53/191 (27%), Positives = 94/191 (49%), Gaps = 5/191 (2%) Query: 619 VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT 678 V+ ++ A Q+T D +F +I EL + + N+ F RRFN++ +WV Sbjct: 49 VTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAP-NVVAFTRRFNQVSFWVVR 107 Query: 679 ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV 738 E+ RA++L F+K+A L E NL+S +V+ L ++ I RL TW L K Sbjct: 108 EILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKD 167 Query: 739 RKLYSALERLLDPSWNHRVYRLALAKLS-PPVIPFMPLLLKDMTFI---HEGNHTLVENL 794 + + L+ L+ N++ R + L P IP++ + L D+ +I + + +++EN Sbjct: 168 KTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENE 227 Query: 795 INFEKMRMMAR 805 +M + R Sbjct: 228 QRSNQMNNILR 238 >gi|15529996 son of sevenless homolog 1 [Homo sapiens] Length = 1333 Score = 72.4 bits (176), Expect = 2e-12 Identities = 51/202 (25%), Positives = 99/202 (49%), Gaps = 13/202 (6%) Query: 611 GSAEGLDLVSAK--DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRR 668 G E DL++ ++A QLT + L+ ++ EL+ V + +++ + NL + +R Sbjct: 769 GHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKED-KEINSPNLLKMIRH 827 Query: 669 FNELQYWVATELCLCPVPG--PRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISR 726 L W E C+ R ++ + I++ +E N N V+ +++S + R Sbjct: 828 TTNLTLWF--EKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYR 885 Query: 727 LAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEG 786 L HT+E++P + +K+ L + +++ Y L ++PP +PF + L ++ EG Sbjct: 886 LDHTFEQIPSRQKKILEEAHELSED--HYKKYLAKLRSINPPCVPFFGIYLTNILKTEEG 943 Query: 787 NHTLV----ENLINFEKMRMMA 804 N ++ + LINF K R +A Sbjct: 944 NPEVLKRHGKELINFSKRRKVA 965 >gi|117168263 RasGEF domain family, member 1A [Homo sapiens] Length = 481 Score = 70.5 bits (171), Expect = 7e-12 Identities = 66/202 (32%), Positives = 96/202 (47%), Gaps = 24/202 (11%) Query: 624 LAGQLTDHDWSLFNSIHQVELIHYVLGPQHLR------DVT-TANLERFMRRFNELQYWV 676 LA QLT + +SI+ +L+ V L D+T T +LE + FN L V Sbjct: 218 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277 Query: 677 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 736 ATE+C R ++L FI +A N NS A++ G++ S ++RL TW ++ Sbjct: 278 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV-- 335 Query: 737 KVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSPPVIPFMPLLLKDMTFIHE 785 K K + LE +DPS N YR AL + VIP L +KD+ F+H+ Sbjct: 336 KTAK-FDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHK 394 Query: 786 --GNHTLVENLINFEKMRMMAR 805 NH L INF+K ++R Sbjct: 395 IHTNH-LPNGHINFKKFWEISR 415 Score = 30.0 bits (66), Expect = 9.9 Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%) Query: 355 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCA 394 LE L+E + P + P T++ FLL+ RVFMP L A Sbjct: 50 LEALMEHLVPTVDYY-PDRTYIFTFLLSSRVFMPPHDLLA 88 >gi|154689780 son of sevenless homolog 2 [Homo sapiens] Length = 1332 Score = 70.1 bits (170), Expect = 9e-12 Identities = 52/203 (25%), Positives = 101/203 (49%), Gaps = 15/203 (7%) Query: 611 GSAEGLDLVSAK--DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRR 668 G E DL++ ++A QLT + L+ + EL+ V + +++ + NL + +R Sbjct: 767 GQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKED-KEINSPNLLKMIRH 825 Query: 669 FNELQYWVATELCLCPVPG--PRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISR 726 L W E C+ R +L + I++ ++ N N ++ +++ ++ R Sbjct: 826 TTNLTLWF--EKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYR 883 Query: 727 LAHTWERLPHKVRKLYSALERLLDPSWNH-RVYRLALAKLSPPVIPFMPLLLKDMTFIHE 785 L HT+E L + RK+ L+ ++ S +H + Y + L ++PP +PF + L ++ E Sbjct: 884 LDHTFEALQERKRKI---LDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEE 940 Query: 786 GNHTLV----ENLINFEKMRMMA 804 GN+ + ++LINF K R +A Sbjct: 941 GNNDFLKKKGKDLINFSKRRKVA 963 >gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] Length = 609 Score = 67.0 bits (162), Expect = 7e-11 Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 3/164 (1%) Query: 617 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 676 D + +LA LT ++ F I + +V H V LERF+ FN + WV Sbjct: 151 DHLEPMELAEHLTYLEYRSFCKILFQDYHSFVT---HGCTVDNPVLERFISLFNSVSQWV 207 Query: 677 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 736 + P RA ++ F+ +A L + +N N+ AV+ GLS+S+ISRL T + Sbjct: 208 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267 Query: 737 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 780 + KL+ L L+ + N+ YR LA P + + LKD+ Sbjct: 268 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDL 311 Score = 38.5 bits (88), Expect = 0.028 Identities = 26/109 (23%), Positives = 50/109 (45%), Gaps = 10/109 (9%) Query: 350 TPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSE 409 T E++L +EA DP + FL+ H ++PS+QL A LLH + + Sbjct: 12 TVEELLRGCIEAFDDSGKVRDPQ--LVRMFLMMHPWYIPSSQLAAKLLHIY--------Q 61 Query: 410 QERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRD 458 Q R + + + LV W++ + + +P +++L L+ ++ Sbjct: 62 QSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQE 110 >gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] Length = 609 Score = 67.0 bits (162), Expect = 7e-11 Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 3/164 (1%) Query: 617 DLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWV 676 D + +LA LT ++ F I + +V H V LERF+ FN + WV Sbjct: 151 DHLEPMELAEHLTYLEYRSFCKILFQDYHSFVT---HGCTVDNPVLERFISLFNSVSQWV 207 Query: 677 ATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPH 736 + P RA ++ F+ +A L + +N N+ AV+ GLS+S+ISRL T + Sbjct: 208 QLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSP 267 Query: 737 KVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDM 780 + KL+ L L+ + N+ YR LA P + + LKD+ Sbjct: 268 ETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVHLKDL 311 Score = 38.5 bits (88), Expect = 0.028 Identities = 26/109 (23%), Positives = 50/109 (45%), Gaps = 10/109 (9%) Query: 350 TPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSE 409 T E++L +EA DP + FL+ H ++PS+QL A LLH + + Sbjct: 12 TVEELLRGCIEAFDDSGKVRDPQ--LVRMFLMMHPWYIPSSQLAAKLLHIY--------Q 61 Query: 410 QERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRD 458 Q R + + + LV W++ + + +P +++L L+ ++ Sbjct: 62 QSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQE 110 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.135 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 36,376,512 Number of Sequences: 37866 Number of extensions: 1718765 Number of successful extensions: 4623 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 54 Number of HSP's successfully gapped in prelim test: 43 Number of HSP's that attempted gapping in prelim test: 4431 Number of HSP's gapped (non-prelim): 171 length of query: 881 length of database: 18,247,518 effective HSP length: 111 effective length of query: 770 effective length of database: 14,044,392 effective search space: 10814181840 effective search space used: 10814181840 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.