Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 19924149
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
(839 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 1682 0.0
gi|167555127 CD180 molecule [Homo sapiens] 228 1e-59
gi|19718734 toll-like receptor 2 [Homo sapiens] 189 7e-48
gi|16751843 toll-like receptor 5 [Homo sapiens] 167 3e-41
gi|4507531 toll-like receptor 3 [Homo sapiens] 166 6e-41
gi|20302168 toll-like receptor 8 [Homo sapiens] 166 8e-41
gi|20143971 toll-like receptor 6 [Homo sapiens] 159 1e-38
gi|7706093 toll-like receptor 7 [Homo sapiens] 148 2e-35
gi|41350337 toll-like receptor 1 [Homo sapiens] 146 7e-35
gi|62865621 toll-like receptor 10 precursor [Homo sapiens] 143 8e-34
gi|62865618 toll-like receptor 10 precursor [Homo sapiens] 143 8e-34
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 139 1e-32
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 92 2e-18
gi|225579152 insulin-like growth factor binding protein, acid la... 89 1e-17
gi|4826772 insulin-like growth factor binding protein, acid labi... 89 1e-17
gi|51317373 netrin-G1 ligand [Homo sapiens] 89 2e-17
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 89 2e-17
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 88 4e-17
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 86 2e-16
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 86 2e-16
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 84 7e-16
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 84 7e-16
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 83 1e-15
gi|188528675 slit homolog 1 [Homo sapiens] 81 5e-15
gi|12007646 nyctalopin precursor [Homo sapiens] 77 5e-14
gi|194440719 chondroadherin-like [Homo sapiens] 77 7e-14
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 77 9e-14
gi|198041768 synleurin [Homo sapiens] 76 1e-13
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 75 3e-13
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 75 3e-13
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 1682 bits (4355), Expect = 0.0
Identities = 839/839 (100%), Positives = 839/839 (100%)
Query: 1 MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD 60
MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD
Sbjct: 1 MMSASRLAGTLIPAMAFLSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLD 60
Query: 61 LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG 120
LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG
Sbjct: 61 LSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALG 120
Query: 121 AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL 180
AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL
Sbjct: 121 AFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHL 180
Query: 181 DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL 240
DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL
Sbjct: 181 DLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSL 240
Query: 241 NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI 300
NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI
Sbjct: 241 NVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDI 300
Query: 301 IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS 360
IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS
Sbjct: 301 IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS 360
Query: 361 NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG 420
NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG
Sbjct: 361 NKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLG 420
Query: 421 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 480
LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG
Sbjct: 421 LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAG 480
Query: 481 NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY 540
NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY
Sbjct: 481 NSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY 540
Query: 541 KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL 600
KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL
Sbjct: 541 KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQL 600
Query: 601 LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML 660
LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML
Sbjct: 601 LVEVERMECATPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVYKFYFHLML 660
Query: 661 LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA 720
LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA
Sbjct: 661 LAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA 720
Query: 721 NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR 780
NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR
Sbjct: 721 NIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLR 780
Query: 781 QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI 839
QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI
Sbjct: 781 QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKSWNPEGTVGTGCNWQEATSI 839
>gi|167555127 CD180 molecule [Homo sapiens]
Length = 661
Score = 228 bits (582), Expect = 1e-59
Identities = 188/642 (29%), Positives = 302/642 (47%), Gaps = 31/642 (4%)
Query: 25 SWEP-CVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVL 83
SW+ C+E N TY C L +IPD LP +T+ L+ SFN L + + +F L L
Sbjct: 23 SWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFL 82
Query: 84 DLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLEN 143
DL+RC+I I + +QS LSTL+LTGNP+ +A + +G SL+ L ++T +++LE
Sbjct: 83 DLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEF 142
Query: 144 FPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPL 203
P+ +L+ L+ L + N I S K P+ F NL+ LD +N I I D+R L Q
Sbjct: 143 IPVHNLENLESLYLGSNHISSIKFPKDFP-ARNLKVLDFQNNAIHYISREDMRSLEQA-- 199
Query: 204 LNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEF 263
+NLSL+ + N + I+ GAF L NF + GL L LG F
Sbjct: 200 INLSLNFNGNNVKGIELGAFDSTIFQSL----NFGGTPNLSVIFNGLQNSTTQSLWLGTF 255
Query: 264 RNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDL-FNCLTNVSSFSLVSVTIER 322
+ + E + L+GLC +++E L ++ DI F C T + L + ++
Sbjct: 256 EDIDD-EDISSAMLKGLCEMSVESLNLQ--EHRFSDISSTTFQCFTQLQELDLTATHLKG 312
Query: 323 VKDFSYNFGW-QHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVD------LPSL 375
+ + L L F Q + + LT +G + L +L
Sbjct: 313 LPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNL 372
Query: 376 EFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNL 434
+ LDLS N + CCS + L+ L+LS N + + S F QLE LD + L
Sbjct: 373 QTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRL 432
Query: 435 KQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLP--DIF 492
+ S F +L L L++++ + + GL L L + GN FQ+ + ++
Sbjct: 433 HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLL 492
Query: 493 TELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFF--SLDTFPYKCLNSLQVLD 550
+ +L L LS C L + AF+SL + +++SHN+ S+D+ + L +
Sbjct: 493 QTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAA 552
Query: 551 YSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECA 610
S+N I L S + +NL+ N CTC + FL W K+ L E CA
Sbjct: 553 NSINII----SPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCA 608
Query: 611 TPSDKQGMPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVY 652
P +G+ + + ++C + T IG+ L V ++ ++A+L++
Sbjct: 609 NPPSLRGVKLSDVKLSCGI--TAIGIFFLIVFLL-LLAILLF 647
>gi|19718734 toll-like receptor 2 [Homo sapiens]
Length = 784
Score = 189 bits (481), Expect = 7e-48
Identities = 227/824 (27%), Positives = 349/824 (42%), Gaps = 143/824 (17%)
Query: 48 IPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTL 107
IP L + K+LDLS N + ++ + LQ L L+ I TIE+ ++ SL L L
Sbjct: 46 IPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHL 105
Query: 108 ILTGNPIQSLALGAFSGLSSLQKLVAVETNLASL-ENFPIGHLKTLKELNVAHNLIQSFK 166
L+ N + +L+ F LSSL L + +L E HL L+ L V + +
Sbjct: 106 DLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKI 165
Query: 167 LPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSL------------------ 208
+ F+ LT LE L++ ++ +QS L+ + + L L +
Sbjct: 166 QRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVE 225
Query: 209 -----DLSLNPMNF--IQPGAFKEIRLHKLTLRN----NFDSLNVMKTC--IQGLAGLEV 255
D L+ +F + G + + K T RN + VMK I GL LE
Sbjct: 226 CLELRDTDLDTFHFSELSTGETNSL-IKKFTFRNVKITDESLFQVMKLLNQISGLLELEF 284
Query: 256 HRLVL---GEFRNEGNLEKFDKSALEGLC--NLTIEEFRLAYLDYYLDDIIDLFNCLTNV 310
L G FR N D +E L L I F L Y D+ L++ V
Sbjct: 285 DDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFY------DLSTLYSLTERV 338
Query: 311 SSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKG-----GN 365
+T+E K F LV C Q LKSL+ L + N N
Sbjct: 339 KR-----ITVENSKVF----------LVPCLLSQH----LKSLEYLDLSENLMVEEYLKN 379
Query: 366 AFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLE 425
+ E PSL+ L L +N L+ S G T L L+ L
Sbjct: 380 SACEDAWPSLQTLILRQNHLA-----SLEKTGET------------------LLTLKNLT 416
Query: 426 HLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQE 485
++D ++ M E + + YL++S T I +LE+L ++ N+
Sbjct: 417 NIDISKNSFHSMPETCQWPE--KMKYLNLSSTRIHSVTGCI---PKTLEILDVSNNNL-- 469
Query: 486 NFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNS 545
NL L+L Q L+ L +S N +L L
Sbjct: 470 -----------NLFSLNLPQ----------------LKELYISRNKLMTLPDA--SLLPM 500
Query: 546 LQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVE-V 604
L VL S N I T K++L F +L L N+F C+CE SF Q + ++L++
Sbjct: 501 LLVLKISRNAITTFSKEQLDSF-HTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWP 559
Query: 605 ERMECATPSDKQGMPVLSLNIT---CQMNKTIIGVSVLSVLVVSVVAVLVYKFY--FHLM 659
C +PS +G V + ++ C + G+ L++ + VL ++F+ +++
Sbjct: 560 ANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMK 619
Query: 660 LLAGCIKYGR------GENI-YDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDF 712
++ ++ R NI YDAFV YS +D WV N +V+ LE PPF+LCLH RDF
Sbjct: 620 MMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDF 679
Query: 713 IPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQ 772
IPG I NII + KS K + V+S++F++S WC +E + + F + I I+L+
Sbjct: 680 IPGKWIIDNII-DSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLE 738
Query: 773 KVEKTLLRQQ-VELYRLLSRNTYLEWEDSVLGRHIFWRRLRKAL 815
+EK + Q+ +L ++++ TYLEW R FW LR A+
Sbjct: 739 PIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAI 782
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 167 bits (424), Expect = 3e-41
Identities = 202/831 (24%), Positives = 358/831 (43%), Gaps = 88/831 (10%)
Query: 44 NFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDL-SRCEIQTIEDGAYQSLS 102
N ++P L +T+ L LSFN +R + + SF +LQ+L+L S+ TI+ A+++L
Sbjct: 37 NLTQVPQVLN-TTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLP 95
Query: 103 HLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNL--ASLENFPIGHLKTLKELNVAHN 160
+L L L + I L AF GL L +L L A L++ +LK L L+++ N
Sbjct: 96 NLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKN 155
Query: 161 LIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDL-SLNPMNFIQ 219
I+S L F L +L+ +D SSN+I + +L L L SL SL +
Sbjct: 156 QIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVD 215
Query: 220 PGA----FKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVL-----GEFRNEGNLE 270
G F+ + L L + N ++++ ++ + L+L G N++
Sbjct: 216 WGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIK 275
Query: 271 KFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNF 330
D++ GL ++ L++ + +F L ++ +L I ++ D ++ +
Sbjct: 276 DPDQNTFAGLARSSVRHLDLSH-GFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAF-Y 333
Query: 331 GWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGC 390
G +L+++N + L ++SN G LP + ++DL +N ++
Sbjct: 334 GLDNLQVLNLSYNLLGEL---------YSSNFYG-------LPKVAYIDLQKNHIAI--I 375
Query: 391 CSQSDFGTTSLKYLDLSFNGVITMS------SNFLGLEQLEHLDFQH--SNLKQMSEFSV 442
Q+ L+ LDL N + T+ FL +L L + +NL +SE
Sbjct: 376 QDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENR- 434
Query: 443 FLSLRNLIY--LDISHTHTRVAFNGIFNGLS---------SLEVLKMAGNSFQ----ENF 487
L +++Y L + H + F+ S SLE L + N Q
Sbjct: 435 -LENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETEL 493
Query: 488 LPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQ 547
D+F L +L L L+ L L P F+ L++L+ L+++ N L +L+
Sbjct: 494 CWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLE 551
Query: 548 VLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVER- 606
+LD S N ++ SL+ L++T N F C CE +F+ W+ +
Sbjct: 552 ILDISRNQLLAPNPDVFV----SLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPAD 607
Query: 607 MECATPSDKQGMPVLSLN------------------ITCQMNKTIIGVSVLSVLVVSVVA 648
+ C P G+ + SL+ I C + T+ +++L+V
Sbjct: 608 IYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFC 667
Query: 649 VLVYKFYFHLMLLAGCIKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPP---FQL 705
+ YK L+ YDA++ +SS+D WV+N L+K+L+ F L
Sbjct: 668 FICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNL 727
Query: 706 CLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAG 765
C RDF+PG ANI + SRK++ +VS+HF++ WC+ + AQ +
Sbjct: 728 CFEERDFVPGENRIANI-QDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSA 786
Query: 766 IIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALL 816
+I +V+ + + L + + + + YL W + + F +L + +L
Sbjct: 787 LIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQIL 837
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 166 bits (421), Expect = 6e-41
Identities = 212/855 (24%), Positives = 362/855 (42%), Gaps = 109/855 (12%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C L ++PD+LP + L+L+ N LR L + +F + +L LD+ I +E Q
Sbjct: 37 CSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQ 96
Query: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
L L L L N + L+ F+ ++L +L + ++ ++N P K L L+++H
Sbjct: 97 KLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSH 156
Query: 160 NLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQ 219
N + S KL L NL+ L LS+NKIQ++ +L + L L +LS N +
Sbjct: 157 NGLSSTKLGTQVQ-LENLQELLLSNNKIQALKSEELDIFANSSLKKL--ELSSNQIKEFS 213
Query: 220 PGAFKEI-RLHKLTLRN-NFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSAL 277
PG F I RL L L N K C++ LA + L L + L +
Sbjct: 214 PGCFHAIGRLFGLFLNNVQLGPSLTEKLCLE-LANTSIRNLSL----SNSQLSTTSNTTF 268
Query: 278 EGL--CNLTIEEFR--------------LAYLDYYL---DDIIDLF-------------N 305
GL NLT+ + L L+Y+ ++I LF N
Sbjct: 269 LGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLN 328
Query: 306 CLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLK---------------- 349
+ + S+ ++ ++ DFS+ + + LE +N + P +K
Sbjct: 329 LKRSFTKQSISLASLPKIDDFSFQW-LKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLS 387
Query: 350 -----LKSLKRLTFTS---------NKGGNAFSEVD------LPSLEFLDLSRNGLSFKG 389
L++L TF S N N S+++ L LE LDL N + +
Sbjct: 388 NSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIG-QE 446
Query: 390 CCSQSDFGTTSLKYLDLSFNGVITMSSNFLGL-EQLEHLDFQHSNLKQM-SEFSVFLSLR 447
Q G ++ + LS+N + ++ N L L+ L + LK + S S F LR
Sbjct: 447 LTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLR 506
Query: 448 NLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFL------PDIFTE-LRNLTF 500
NL LD+S+ + + + GL LE+L + N+ + P F + L +L
Sbjct: 507 NLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHI 566
Query: 501 LDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSK 560
L+L +++ F L L+++++ NN +L + SL+ L+ N I + +
Sbjct: 567 LNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVE 626
Query: 561 KQELQHFPSSLAFLNLTQNDFACTCEHQS-FLQWIKDQRQLLVEV-ERMECATPSDKQGM 618
K+ +L L++ N F CTCE + F+ WI + + E+ C TP G
Sbjct: 627 KKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGF 686
Query: 619 PVLSLNITCQMNKT------IIGVSVLSVLVVSVVAVLV----YKFYF----HLMLLAGC 664
PV + + + +I S+L + + V+ + FY+ H +L
Sbjct: 687 PVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKE 746
Query: 665 IKYGRGENIYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIH 724
I + Y A++I++ +D+DWV E ++E+ + CL RDF GV I++
Sbjct: 747 IDRQTEQFEYAAYIIHAYKDKDWVW-EHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVN 805
Query: 725 EGFHKSRKVIVVVSQHFIQSRWC-IFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQV 783
+SRK+I V++ H ++ C F+ A + II + L+++ L +
Sbjct: 806 -SIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHAL 864
Query: 784 ELYR-LLSRNTYLEW 797
L R + + L W
Sbjct: 865 CLRRGMFKSHCILNW 879
Score = 30.0 bits (66), Expect = 9.3
Identities = 20/81 (24%), Positives = 37/81 (45%), Gaps = 1/81 (1%)
Query: 502 DLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKK 561
+++ C +L+ + +++ VLN++HN L + + L LD N I +
Sbjct: 33 EVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEP 92
Query: 562 QELQHFPSSLAFLNLTQNDFA 582
+ Q P L LNL N+ +
Sbjct: 93 ELCQKLP-MLKVLNLQHNELS 112
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 166 bits (420), Expect = 8e-41
Identities = 220/871 (25%), Positives = 381/871 (43%), Gaps = 108/871 (12%)
Query: 20 CVRPESWEPCVEVVPNITYQCMELNFYK-IPDNLPFSTKNLDLSFNPLRHLGSYSFFSFP 78
C + + E + N+ + N +P LP S + L LS ++++ F
Sbjct: 187 CEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLI 246
Query: 79 ELQVLDLS----RC-------------EIQTIEDGAYQSLSHLSTLILTGNPIQSLALGA 121
L +LDLS RC I+ A+Q+L+ L L L+ ++ +
Sbjct: 247 NLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAW 306
Query: 122 FSGLSSLQKLVAVETNLASLENFP---IGHLKTLKELNVAHNLI-----QSFKLPEYFSN 173
F + L K++ +E N E + L L+ L+++ N I Q + FS
Sbjct: 307 FKNMPHL-KVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSK 365
Query: 174 LTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTL 233
L +L L L Q + D + L Q+P L+ +++L +N + I F+ ++
Sbjct: 366 LLSLRALHLRGYVFQELREDDFQPLMQLPNLS-TINLGINFIKQIDFKLFQNFSNLEIIY 424
Query: 234 RNNFDSLNVMKTCIQGLAG-------LEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIE 286
+ ++K Q A + R EF N F + ++ C
Sbjct: 425 LSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQC----- 479
Query: 287 EFRLAY---LDYYLDDIIDL----FNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVN 339
AY LD L+ I + F L +++ +L + + +V L
Sbjct: 480 ---AAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQV-------------LSG 523
Query: 340 CKFGQFPTLKLKSL--KRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFK--GCCSQSD 395
+F P +K L RL F NA + +L LE LDLS N F+ G +
Sbjct: 524 TEFSAIPHVKYLDLTNNRLDFD-----NASALTELSDLEVLDLSYNSHYFRIAGVTHHLE 578
Query: 396 F--GTTSLKYLDLSFNGVITMSSNF-LGLEQLEHLDFQHSNLKQMSE------FSVFLSL 446
F T+LK L+LS N + T++ + L + L L F + L + S+F L
Sbjct: 579 FIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGL 638
Query: 447 RNLIYLDISHTHTRVAFNGIFNGL-SSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQ 505
+NL LD+S + N F L +SL L + N + F + + L LDL
Sbjct: 639 KNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKF-FNWTLLQQFPRLELLDLRG 697
Query: 506 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQ 565
+L L+ + + SSL+ L +SHN L + ++SL+ LD S N + T K L+
Sbjct: 698 NKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALE 757
Query: 566 -HFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERME---CATPSDKQGMPVL 621
+ L+ L L N F CTC+ F +W+ + L V++ R+ CA+P D++G ++
Sbjct: 758 TKTTTKLSMLELHGNPFECTCDIGDFRRWMDE--HLNVKIPRLVDVICASPGDQRGKSIV 815
Query: 622 SLNI-TCQMNKTIIGVSVLSVLVVSVV---AVLVYKFYFHLMLLAG-CIKYGRG------ 670
SL + TC + T + + + + ++V A+ + FY+ + + C+ +G
Sbjct: 816 SLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLST 875
Query: 671 -ENIYDAFVIYSSQD---EDWVRNELVKNLEEGVPP-FQLCLHYRDFIPGVAIAANIIHE 725
+ YDA++ Y ++D DWV NEL +LEE LCL RD+ PG+AI N++ +
Sbjct: 876 SQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLM-Q 934
Query: 726 GFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVEL 785
++S+K + V+++ + +S + +A + IIFI+L+ V + Q + L
Sbjct: 935 SINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQH--SQYLRL 992
Query: 786 YRLLSRNTYLEWEDSVLGRHIFWRRLRKALL 816
+ + +++ L+W D+ +FW+ LR +L
Sbjct: 993 RQRICKSSILQWPDNPKAEGLFWQTLRNVVL 1023
Score = 70.5 bits (171), Expect = 6e-12
Identities = 140/593 (23%), Positives = 248/593 (41%), Gaps = 91/593 (15%)
Query: 28 PCVEVVPN--ITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDL 85
PC E N + +C ++P + LDLS N + H+ + SF L ++L
Sbjct: 35 PCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINL 94
Query: 86 SRCE----------IQT----IEDGAYQSLSHLSTLILTGNPIQSLALGAFSGL-SSLQK 130
+ IQ+ I DGA+ +L +L L+L N + + SGL SL +
Sbjct: 95 NHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIP----SGLPESLTE 150
Query: 131 LVAVETNLASLENFPIGHLKTLKELNVAHN-----LIQSFKLPE-YFSNLTNLEHLDLSS 184
L ++ N+ ++ I L LK L +A N + + + + F LTNLE L LS
Sbjct: 151 LSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSF 210
Query: 185 NKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKE-IRLHKLTLRNNFDS-LNV 242
N + V ++P L LS + +I FK I L L L N N
Sbjct: 211 NSLS-------HVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNA 263
Query: 243 MKTCI--QGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFR-LAYLDYYLDD 299
C+ G A + + R F+N L + S+ L + F+ + +L
Sbjct: 264 PFPCVPCDGGASINIDRFA---FQNLTQLRYLNLSSTS-LRKINAAWFKNMPHLK----- 314
Query: 300 IIDL-FNCLTNVSSFSLVSVTIERVKDFSYNFGW------QHLELVNCKFGQFPTLKLKS 352
++DL FN L + + R++ +F + QH+ ++ F + +L+
Sbjct: 315 VLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHIN-ISRNFSKLLSLRALH 373
Query: 353 LKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDF----GTTSLKYLDLSF 408
L+ F + + + LP+L ++L G++F Q DF ++L+ + LS
Sbjct: 374 LRGYVFQELREDDFQPLMQLPNLSTINL---GINF---IKQIDFKLFQNFSNLEIIYLSE 427
Query: 409 NGVITM----------SSNFLG-LEQLEHLDFQ---HSNLKQMSEFSVFLSLRNLIY--- 451
N + + SS+F + + DF+ HSN + + + Y
Sbjct: 428 NRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTR--PLIKPQCAAYGKA 485
Query: 452 LDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQL 511
LD+S F L + L ++ NS + F+ + ++ +LDL+ +L+
Sbjct: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFD 545
Query: 512 SPTAFNSLSSLQVLNMSHN-NFFSLDTFPY-----KCLNSLQVLDYSLNHIMT 558
+ +A LS L+VL++S+N ++F + + + +L+VL+ S N+I T
Sbjct: 546 NASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYT 598
>gi|20143971 toll-like receptor 6 [Homo sapiens]
Length = 796
Score = 159 bits (402), Expect = 1e-38
Identities = 200/809 (24%), Positives = 357/809 (44%), Gaps = 116/809 (14%)
Query: 48 IPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTL 107
+P +LP TK LD+S N + ELQV D+S LS L+ L
Sbjct: 46 VPKDLPLKTKVLDMSQNYIA-----------ELQVSDMS-------------FLSELTVL 81
Query: 108 ILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKL 167
L+ N IQ L L F L+ L L + PI + + L+++ N ++ +
Sbjct: 82 RLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPI---VSFRHLDLSFNDFKALPI 138
Query: 168 PEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIR 227
+ F NL+ L L LS+ K+Q + DL + + L + LDL + + + + +
Sbjct: 139 CKEFGNLSQLNFLGLSAMKLQKL---DLLPIAHLHLSYILLDLRNYYIKENETESLQILN 195
Query: 228 LHKLTLRNNFDSLNVMKT--CIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTI 285
L L + SL ++ + L L++ + L N+ N + F K E T+
Sbjct: 196 AKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKL----NDDNCQVFIKFLSELTRGSTL 251
Query: 286 EEFRLAYLDYYLDDIIDLFNCL-----TNVSSFSLVSVTIERVKDFSYNFGWQHLELVNC 340
F L +++ ++ +F L ++ ++L + R +DF+Y+
Sbjct: 252 LNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSK---------- 301
Query: 341 KFGQFPTLKLKSLKRLT-----FTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSD 395
TLK +++ +T F+ FSE+++ L D + C +
Sbjct: 302 -----TTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHM----LCPHAP 352
Query: 396 FGTTSLKYLDLSFNGVITMS--SNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLD 453
++ K+L+ + N V T S L +LE L Q + LK + F V L +++ L+
Sbjct: 353 ---STFKFLNFTQN-VFTDSIFEKCSTLVKLETLILQKNGLKDL--FKVGLMTKDMPSLE 406
Query: 454 ISHTHTRVAFNGIFNG--------LSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQ 505
I V++N + +G + S+ VL ++ N ++ + ++ LDL
Sbjct: 407 ILD----VSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIK---VLDLHS 459
Query: 506 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDY-SLNHIMTSKKQEL 564
+++ + P L +LQ LN++ N+ L S+ ++D+ S++H Q
Sbjct: 460 NKIKSV-PKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSC 518
Query: 565 QHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVE--VERMECATPSDKQGMPVLS 622
Q S + N F CTCE + F++ I ++E + +C P +G P+
Sbjct: 519 QKMRS----IKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKD 574
Query: 623 LN---ITCQMNKTIIGV-SVLSVLVVSVVAVLVYKF--YFHLMLLAGCIKYGRGENI--- 673
+ ++C + I+ + + + VL V+V ++ +Y ++ M+ R NI
Sbjct: 575 FHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLE 634
Query: 674 -------YDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEG 726
+ AF+ YS D WV++ELV LE+ Q+CLH R+F+PG +I NII+
Sbjct: 635 ELQRNLQFHAFISYSEHDSAWVKSELVPYLEK--EDIQICLHERNFVPGKSIVENIIN-C 691
Query: 727 FHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKV-EKTLLRQQVEL 785
KS K I V+S +F+QS WC +E A F +I I+L+ + + ++ + +L
Sbjct: 692 IEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKL 751
Query: 786 YRLLSRNTYLEWEDSVLGRHIFWRRLRKA 814
L+++ TYL+W R +FW +R A
Sbjct: 752 KALMTQRTYLQWPKEKSKRGLFWANIRAA 780
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 148 bits (373), Expect = 2e-35
Identities = 204/841 (24%), Positives = 365/841 (43%), Gaps = 91/841 (10%)
Query: 44 NFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLS----RC----------- 88
N +P LP + L L N + + F + +LQ+LDLS RC
Sbjct: 215 NVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCK 274
Query: 89 --EIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLAS-LENFP 145
I A+ +L+ L L L N +Q + F ++ LQ+L + LA + +
Sbjct: 275 NNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAK 334
Query: 146 IGH-LKTLKELNVAHNLI-----QSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLH 199
H L +L +L+++ N S L + FS+L +L+ L + + + +L LH
Sbjct: 335 FLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLH 394
Query: 200 QMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLT------LRNNFDSLNVMKTCIQGLAGL 253
+ L + LDL N + FK+ + K+ + + DS V C +
Sbjct: 395 NLQNLEV-LDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEV-GFCSNARTSV 452
Query: 254 EVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLD---YYLDDIIDLF-NCLTN 309
E + + E + +K+ +S C +E ++ Y +DL N +
Sbjct: 453 ESYEPQVLEQLHYFRYDKYARS-----CRFKNKEASFMSVNESCYKYGQTLDLSKNSIFF 507
Query: 310 VSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNK----GGN 365
V S ++ + + S N L++ L L+ L F++N+
Sbjct: 508 VKSSDFQHLSFLKCLNLSGN-------LISQTLNGSEFQPLAELRYLDFSNNRLDLLHST 560
Query: 366 AFSEVDLPSLEFLDLSRNGLSFK--GCCSQSDFGTTSLKYLD---LSFNGVITMSSNFLG 420
AF E L LE LD+S N F+ G +F T +LK L ++ N + + +S +
Sbjct: 561 AFEE--LHKLEVLDISSNSHYFQSEGITHMLNF-TKNLKVLQKLMMNDNDISSSTSRTME 617
Query: 421 LEQLEHLDFQHSNLKQMSE------FSVFLSLRNLIYLDISHTHTRVAFNGIFNGLS-SL 473
E L L+F+ ++L + +F +L L LDIS +G+F+G+ +L
Sbjct: 618 SESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNL 677
Query: 474 EVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFF 533
+ L +A N + +F L+NL LDLS QL + N SL+ L + +N
Sbjct: 678 KNLSLAKNGLK-SFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIR 736
Query: 534 SLDTFPYKCLNSLQVLDYSLNHI-MTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQ 592
SL + + L+ LD S N I M K ++ ++L L L N F CTC+ F+
Sbjct: 737 SLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVW 796
Query: 593 WIKDQRQLLVEVER-MECATPSDKQGMPVLSLNI-TCQMNKTIIGVSVLSVLVVSVVAVL 650
W+ + + + C P +G V+SL++ TC+++ T + + LS+ V + V+
Sbjct: 797 WVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVM 856
Query: 651 V-----------YKFYFHLMLLAGCIKYGRGENIYDAFVIYSSQD---EDWVRNELVKNL 696
+ Y ++F + G + + YDAF++Y ++D +WV ELV L
Sbjct: 857 MTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKL 916
Query: 697 EE-GVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQ 755
E+ F LCL RD++PG + N + + S+K + V++ + ++ + ++
Sbjct: 917 EDPREKHFNLCLEERDWLPGQPVLEN-LSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSH 975
Query: 756 TWQFLSSRAGIIFIVLQKVEKTLLRQQ-VELYRLLSRNTYLEWEDSVLGRHIFWRRLRKA 814
+ + + +I ++ +EK + + ++L + L ++ LEW + FW+ L+ A
Sbjct: 976 Q-RLMDEKVDVIILIF--LEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNA 1032
Query: 815 L 815
L
Sbjct: 1033 L 1033
Score = 84.7 bits (208), Expect = 3e-16
Identities = 143/615 (23%), Positives = 229/615 (37%), Gaps = 127/615 (20%)
Query: 35 NITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIE 94
++ C + + +IP +P +T NL L+ N + + SF L +D RC I
Sbjct: 46 HVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDF-RCNCVPIP 104
Query: 95 DGA---------------YQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLA 139
G+ + L++L +L L GN + + G SLQ L N+
Sbjct: 105 LGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLSLEANNIF 161
Query: 140 SLENFPIGHLKTLKELNVAHNLIQSFKLPEY---------FSNLTNLEHLDLSSNKIQSI 190
S+ + L ++ L + N ++ P Y F NLT L+ L L N + ++
Sbjct: 162 SIRKENLTELANIEILYLGQNCY--YRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAV 219
Query: 191 YCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEI-RLHKLTLRNNF------------ 237
L ++ L N N + IQ F + +L L L N
Sbjct: 220 PTVLPSTLTELYLYN-------NMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAP 272
Query: 238 ----DSLNVMKTCIQGLAGLEVHRLVLGE--------FRNEGNLEKFDKSALEGLCNLTI 285
L + L L+V RL F+N L++ D S N
Sbjct: 273 CKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQ-----NFLA 327
Query: 286 EEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLEL---VNCKF 342
+E A ++L +I L D S+NF Q ++ F
Sbjct: 328 KEIGDAKFLHFLPSLIQL---------------------DLSFNFELQVYRASMNLSQAF 366
Query: 343 GQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLK 402
+LK+ ++ F K N +L +LE LDL N + F LK
Sbjct: 367 SSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF--KRLK 424
Query: 403 YLDLSFNGVITMS-SNFLG----------------LEQLEHLDFQHSNLKQMSEF----S 441
+DLS N + S+ +G LEQL + F++ + F +
Sbjct: 425 VIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHY--FRYDKYARSCRFKNKEA 482
Query: 442 VFLSLRNLIY-----LDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELR 496
F+S+ Y LD+S + F LS L+ L ++GN + F L
Sbjct: 483 SFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLA 542
Query: 497 NLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN-NFFSLDTFPY-----KCLNSLQVLD 550
L +LD S +L+ L TAF L L+VL++S N ++F + + K L LQ L
Sbjct: 543 ELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLM 602
Query: 551 YSLNHIMTSKKQELQ 565
+ N I +S + ++
Sbjct: 603 MNDNDISSSTSRTME 617
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 146 bits (369), Expect = 7e-35
Identities = 199/775 (25%), Positives = 324/775 (41%), Gaps = 125/775 (16%)
Query: 125 LSSLQKLVAVETN-LASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLS 183
LS ++ + N ++ L I L L+ L ++HN IQ + + N LE+LDLS
Sbjct: 43 LSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFN-QELEYLDLS 101
Query: 184 SNKIQSIYCTDLRVLHQMPLLNLS-LDLSLNPMNFI----QPGAFKEIRLHKLTLRNNFD 238
NK+ I C P +NL LDLS N + + + G +++ L+
Sbjct: 102 HNKLVKISC--------HPTVNLKHLDLSFNAFDALPICKEFGNMSQLKFLGLS------ 147
Query: 239 SLNVMKTCIQGLAGLEVHR--LVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYY 296
+ ++ K+ + +A L + + LVLGE E K EGL + E + +
Sbjct: 148 TTHLEKSSVLPIAHLNISKVLLVLGETYGE-------KEDPEGLQDFNTESLHIVF---- 196
Query: 297 LDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRL 356
F+ + +VS ++ ++ + +K + + + K P L +L +
Sbjct: 197 --PTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNI 254
Query: 357 TFTSNKGGN-------------AFSEVDLP-SLEFLDLSRNGLSFKGCCSQ---SD---- 395
T N + S V L L+F D +G S K SD
Sbjct: 255 ETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQVVSDVFGF 314
Query: 396 --------FGTTSLK--------------------YLDLSFNGVI---TMSSNFLGLEQL 424
F ++K +L L F+ + T+ N L +L
Sbjct: 315 PQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENCGHLTEL 374
Query: 425 EHLDFQHSNLKQMSEFS-VFLSLRNLIYLDISHTHTRV-AFNGIFNGLSSLEVLKMAGNS 482
E L Q + LK++S+ + + +++L LDIS G + SL L M+ N
Sbjct: 375 ETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNI 434
Query: 483 FQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKC 542
+ + ++ LDL +++ + P L +LQ LN++ N+ L
Sbjct: 435 LTDTIFRCLPPRIK---VLDLHSNKIKSI-PKQVVKLEALQELNVAFNSLTDLPGCGSFS 490
Query: 543 LNSLQVLDY-SLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLL 601
S+ ++D+ S++H Q Q S + N F CTCE F++ I +
Sbjct: 491 SLSVLIIDHNSVSHPSADFFQSCQKMRS----IKAGDNPFQCTCELGEFVKNIDQVSSEV 546
Query: 602 VE--VERMECATPSDKQG-------MPVLSLNITCQMNKTIIGVSVLSVLVVSVVAVLVY 652
+E + +C P +G M LS NIT + + + VL+V V S+ + L
Sbjct: 547 LEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYLDL 606
Query: 653 KFYFHLMLLAGCIKYGRGENI----------YDAFVIYSSQDEDWVRNELVKNLE-EGVP 701
+Y M+ R NI + AF+ YS D WV+NEL+ NLE EG+
Sbjct: 607 PWYLR-MVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGM- 664
Query: 702 PFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLS 761
Q+CLH R+F+PG +I NII KS K I V+S +F+QS WC +E A F
Sbjct: 665 --QICLHERNFVPGKSIVENII-TCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHE 721
Query: 762 SRAGIIFIVLQKV-EKTLLRQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKAL 815
+I I+L+ + + ++ +L L++R TYLEW R +FW LR A+
Sbjct: 722 GSNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAI 776
Score = 52.8 bits (125), Expect = 1e-06
Identities = 109/462 (23%), Positives = 180/462 (38%), Gaps = 44/462 (9%)
Query: 59 LDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLA 118
L +S N +++L F EL+ LDLS ++ I +L HL L+ N +L
Sbjct: 74 LIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLD---LSFNAFDALP 130
Query: 119 L-GAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNL-TN 176
+ F +S L+ L T+L PI HL K L V + PE + T
Sbjct: 131 ICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGLQDFNTE 190
Query: 177 LEHLDLSSNK-IQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFK---EIRLHKLT 232
H+ +NK I ++ + + L N+ L N ++ K +L LT
Sbjct: 191 SLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLT 250
Query: 233 LRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLE--KFDKSALEGLCNLTIEEFRL 290
L N + N +Q + V + + +G L+ FD S L L+I +
Sbjct: 251 LNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSG-TSLKALSIHQVVS 309
Query: 291 AYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQ--FPTL 348
+ I ++F+ + N+ +F++ + + S + HL+ N F
Sbjct: 310 DVFGFPQSYIYEIFSNM-NIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTVFENC 368
Query: 349 -KLKSLKRLTFTSNK----GGNAFSEVDLPSLEFLDLSRNGLSF---KGCCS-------- 392
L L+ L N+ A + SL+ LD+S+N +S+ KG CS
Sbjct: 369 GHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSL 428
Query: 393 --QSDFGTTS--------LKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSV 442
S+ T + +K LDL N + ++ + LE L+ L+ ++L +
Sbjct: 429 NMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGS 488
Query: 443 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQ 484
F SL LI S +H F F + +K N FQ
Sbjct: 489 FSSLSVLIIDHNSVSHPSADF---FQSCQKMRSIKAGDNPFQ 527
>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 143 bits (360), Expect = 8e-34
Identities = 184/802 (22%), Positives = 345/802 (43%), Gaps = 86/802 (10%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C ++ K+P +L +T LDLS+N L L S F S +L+VL L IQ ++ ++
Sbjct: 34 CSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFE 93
Query: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
L L L+ N ++S+ +GL + L+++
Sbjct: 94 FNKELRYLDLSNNRLKSVTWYLLAGL---------------------------RYLDLSF 126
Query: 160 NLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQ 219
N + + E N+++LE L LS KIQ + LH LN ++ L + +
Sbjct: 127 NDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLH----LN-TVFLGFRTLPHYE 181
Query: 220 PGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEG 279
G+ + KL + D+ N G+ ++ L + + ++
Sbjct: 182 EGSLPILNTTKLHIVLPMDT-NFWVLLRDGIKTSKI--LEMTNIDGKSQFVSYEMQRNLS 238
Query: 280 LCNLTIEEFRLAYLDYYLDDIIDLFNCL--TNVSSFSLVSVTIERVKDFSYN-FGWQHLE 336
L N L +D DD+ + + T+V F + +VT +N F + +
Sbjct: 239 LENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTV 298
Query: 337 LVNCKFGQFPTLKLKSLKRLTF--TSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQS 394
+ T+KL+ + F +K +++D+ +L + + F
Sbjct: 299 M--------RTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNY---- 346
Query: 395 DFGTTSLKYLDLSFNGVIT--MSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYL 452
T +YL+ + N ++T + + L L+ L + L+ +S S F + L +L
Sbjct: 347 ---PTKFQYLNFA-NNILTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTPLEHL 402
Query: 453 DISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTEL-RNLTFLDLSQCQLEQL 511
D+S + + + ++ + ++ N ++ +F L +++ LDL+ Q++ +
Sbjct: 403 DLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDS----VFRCLPKSIQILDLNNNQIQTV 458
Query: 512 SPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSL 571
P L +L+ LN++ N F D + L VL+ +N I++ +Q +
Sbjct: 459 -PKETIHLMALRELNIAFN--FLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSC-QEV 514
Query: 572 AFLNLTQNDFACTCEHQSFLQWIKDQRQLLVE-VERMECATPSDKQGMPVLSLNI-TCQM 629
LN +N F CTCE ++F+Q ++V + C P + +G + +++
Sbjct: 515 KTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSC 574
Query: 630 NKTIIGVSVLSVLVVSVVAVLVYKFYF----HLMLLAGC------IKYGRGENI-----Y 674
N ++ V+++ +++V +AV +F +L +L C ++ E + +
Sbjct: 575 NTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRF 634
Query: 675 DAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVI 734
AF+ YS D WV+NEL+ NLE+ +CL+ F PG +I+ NI+ KS K I
Sbjct: 635 HAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIV-SFIEKSYKSI 693
Query: 735 VVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQV-ELYRLLSRNT 793
V+S +F+Q+ WC +E+ A F + II I+L+ + + + +L LL +
Sbjct: 694 FVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKA 753
Query: 794 YLEWEDSVLGRHIFWRRLRKAL 815
YLEW +FW LR A+
Sbjct: 754 YLEWPKDRRKCGLFWANLRAAI 775
Score = 33.9 bits (76), Expect = 0.65
Identities = 75/302 (24%), Positives = 121/302 (40%), Gaps = 64/302 (21%)
Query: 307 LTNVSSFSLVSVTIERVK-----DFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSN 361
+TN S+ SL V + D SYN +Q L + F L++ L
Sbjct: 31 MTNCSNMSLRKVPADLTPATTTLDLSYNLLFQ---LQSSDFHSVSKLRVLILCH------ 81
Query: 362 KGGNAFSEVDLPSLEF------LDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITM- 414
N ++DL + EF LDLS N L S + + L+YLDLSFN TM
Sbjct: 82 ---NRIQQLDLKTFEFNKELRYLDLSNNRLK-----SVTWYLLAGLRYLDLSFNDFDTMP 133
Query: 415 ----SSNFLGLE-------QLEHLDFQHSNLKQMSEFSVFLSLRNLIY--------LDIS 455
+ N LE +++ DFQ + + +VFL R L + L+ +
Sbjct: 134 ICEEAGNMSHLEILGLSGAKIQKSDFQ--KIAHLHLNTVFLGFRTLPHYEEGSLPILNTT 191
Query: 456 HTHTRVAFNGIF-----NGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLD-----LSQ 505
H + + F +G+ + ++L+M + F+ + RNL+ + L
Sbjct: 192 KLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFVS--YEMQRNLSLENAKTSVLLL 249
Query: 506 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQ 565
+++ L F L + ++ H ++ TF K DYS N +M + K E
Sbjct: 250 NKVDLLWDDLFLILQFVWHTSVEHFQIRNV-TFGGKAYLDHNSFDYS-NTVMRTIKLEHV 307
Query: 566 HF 567
HF
Sbjct: 308 HF 309
>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 143 bits (360), Expect = 8e-34
Identities = 184/802 (22%), Positives = 345/802 (43%), Gaps = 86/802 (10%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C ++ K+P +L +T LDLS+N L L S F S +L+VL L IQ ++ ++
Sbjct: 34 CSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFE 93
Query: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
L L L+ N ++S+ +GL + L+++
Sbjct: 94 FNKELRYLDLSNNRLKSVTWYLLAGL---------------------------RYLDLSF 126
Query: 160 NLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQ 219
N + + E N+++LE L LS KIQ + LH LN ++ L + +
Sbjct: 127 NDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLH----LN-TVFLGFRTLPHYE 181
Query: 220 PGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEG 279
G+ + KL + D+ N G+ ++ L + + ++
Sbjct: 182 EGSLPILNTTKLHIVLPMDT-NFWVLLRDGIKTSKI--LEMTNIDGKSQFVSYEMQRNLS 238
Query: 280 LCNLTIEEFRLAYLDYYLDDIIDLFNCL--TNVSSFSLVSVTIERVKDFSYN-FGWQHLE 336
L N L +D DD+ + + T+V F + +VT +N F + +
Sbjct: 239 LENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTV 298
Query: 337 LVNCKFGQFPTLKLKSLKRLTF--TSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQS 394
+ T+KL+ + F +K +++D+ +L + + F
Sbjct: 299 M--------RTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNY---- 346
Query: 395 DFGTTSLKYLDLSFNGVIT--MSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYL 452
T +YL+ + N ++T + + L L+ L + L+ +S S F + L +L
Sbjct: 347 ---PTKFQYLNFA-NNILTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTPLEHL 402
Query: 453 DISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTEL-RNLTFLDLSQCQLEQL 511
D+S + + + ++ + ++ N ++ +F L +++ LDL+ Q++ +
Sbjct: 403 DLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDS----VFRCLPKSIQILDLNNNQIQTV 458
Query: 512 SPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSL 571
P L +L+ LN++ N F D + L VL+ +N I++ +Q +
Sbjct: 459 -PKETIHLMALRELNIAFN--FLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSC-QEV 514
Query: 572 AFLNLTQNDFACTCEHQSFLQWIKDQRQLLVE-VERMECATPSDKQGMPVLSLNI-TCQM 629
LN +N F CTCE ++F+Q ++V + C P + +G + +++
Sbjct: 515 KTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSC 574
Query: 630 NKTIIGVSVLSVLVVSVVAVLVYKFYF----HLMLLAGC------IKYGRGENI-----Y 674
N ++ V+++ +++V +AV +F +L +L C ++ E + +
Sbjct: 575 NTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRF 634
Query: 675 DAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVI 734
AF+ YS D WV+NEL+ NLE+ +CL+ F PG +I+ NI+ KS K I
Sbjct: 635 HAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIV-SFIEKSYKSI 693
Query: 735 VVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQV-ELYRLLSRNT 793
V+S +F+Q+ WC +E+ A F + II I+L+ + + + +L LL +
Sbjct: 694 FVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKA 753
Query: 794 YLEWEDSVLGRHIFWRRLRKAL 815
YLEW +FW LR A+
Sbjct: 754 YLEWPKDRRKCGLFWANLRAAI 775
Score = 33.9 bits (76), Expect = 0.65
Identities = 75/302 (24%), Positives = 121/302 (40%), Gaps = 64/302 (21%)
Query: 307 LTNVSSFSLVSVTIERVK-----DFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSN 361
+TN S+ SL V + D SYN +Q L + F L++ L
Sbjct: 31 MTNCSNMSLRKVPADLTPATTTLDLSYNLLFQ---LQSSDFHSVSKLRVLILCH------ 81
Query: 362 KGGNAFSEVDLPSLEF------LDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITM- 414
N ++DL + EF LDLS N L S + + L+YLDLSFN TM
Sbjct: 82 ---NRIQQLDLKTFEFNKELRYLDLSNNRLK-----SVTWYLLAGLRYLDLSFNDFDTMP 133
Query: 415 ----SSNFLGLE-------QLEHLDFQHSNLKQMSEFSVFLSLRNLIY--------LDIS 455
+ N LE +++ DFQ + + +VFL R L + L+ +
Sbjct: 134 ICEEAGNMSHLEILGLSGAKIQKSDFQ--KIAHLHLNTVFLGFRTLPHYEEGSLPILNTT 191
Query: 456 HTHTRVAFNGIF-----NGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLD-----LSQ 505
H + + F +G+ + ++L+M + F+ + RNL+ + L
Sbjct: 192 KLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFVS--YEMQRNLSLENAKTSVLLL 249
Query: 506 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQ 565
+++ L F L + ++ H ++ TF K DYS N +M + K E
Sbjct: 250 NKVDLLWDDLFLILQFVWHTSVEHFQIRNV-TFGGKAYLDHNSFDYS-NTVMRTIKLEHV 307
Query: 566 HF 567
HF
Sbjct: 308 HF 309
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 139 bits (350), Expect = 1e-32
Identities = 229/909 (25%), Positives = 382/909 (42%), Gaps = 146/909 (16%)
Query: 1 MMSASRLAGTLIPAMAFL----SCVRPESWEPCVEVVP-------NITYQCMELN-FYKI 48
M+ ++ LAG + A+ FL +C +EV P N+T+ ++ N +
Sbjct: 157 MLDSASLAG--LHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVV 214
Query: 49 PDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLS----RCE------------IQT 92
P NLP S + L LS+N + L + L+VLD+ RC+
Sbjct: 215 PRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQ 274
Query: 93 IEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASL--ENFPIGHLK 150
+ + LS L L+L + + L F GL +L+ L E L + L
Sbjct: 275 LHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLT 334
Query: 151 TLKELNVAHNL-----IQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLN 205
L++LN++ N L F +L L+ LD+ +S+ T LR L ++P+L
Sbjct: 335 QLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQ 394
Query: 206 LSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGE--- 262
+L L +N +N Q G F+ F L + ++G +GE
Sbjct: 395 -TLRLQMNFINQAQLGIFRA-----------FPGLRYVDLSDNRISGASELTATMGEADG 442
Query: 263 ----FRNEGNLEKFDKSALEGLCNLTIEEFR--LAYLDYYLDDIIDLFNCLTNVSSFSLV 316
+ G+L A + + E+FR + L++ LD +S +LV
Sbjct: 443 GEKVWLQPGDL------APAPVDTPSSEDFRPNCSTLNFTLD-----------LSRNNLV 485
Query: 317 SVTIERVKDFSYNFGWQHLELV-NC-----KFGQFPTLKLKSLKRLTFTSNKGG--NAFS 368
+V E S+ Q L L NC QF L L L+ L + NK + S
Sbjct: 486 TVQPEMFAQLSH---LQCLRLSHNCISQAVNGSQF--LPLTGLQVLDLSHNKLDLYHEHS 540
Query: 369 EVDLPSLEFLDLSRNGLSF--KGCCSQSDFGT--TSLKYLDLSFNGVITMSSNFLGLEQL 424
+LP LE LDLS N F +G F +L++L L+ N + + S L L
Sbjct: 541 FTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSL 600
Query: 425 EHLDFQHSNLKQM-SEFSVFL----SLRNLIYLDISHTHTRVAFNGIFNGL-SSLEVLKM 478
LDF + L M +E ++L L LI+LD+S L SL+VL++
Sbjct: 601 RALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRL 660
Query: 479 AGNS------FQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNF 532
N + +FLP L LDL+ QL+ L+ + + + L+ L++S N+
Sbjct: 661 RDNYLAFFKWWSLHFLP-------KLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSI 713
Query: 533 FSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQ 592
+ + L+ L+ S N + T S+L L+++ N C C +F+
Sbjct: 714 SFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACG-AAFMD 772
Query: 593 WIKDQRQLLVEV-ERMECATPSDKQGMPVLSLNITCQMNKTI----IGVSVLSVLVVSVV 647
++ + + + + R++C +P QG+ + + ++ +++ + +S+L+V + V
Sbjct: 773 FLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGV 832
Query: 648 AVLVYK------FYFHLMLLAGCIKY--------GRGENI--YDAFVIYSSQDE---DWV 688
+L + + FHL C+ + GR E+ YDAFV++ DWV
Sbjct: 833 PMLHHLCGWDLWYCFHL-----CLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWV 887
Query: 689 RNELVKNLEE--GVPPFQLCLHYRDFIPGVAIAANIIHEGFHKSRKVIVVVSQHFIQSRW 746
NEL LEE G +LCL RD++PG + N+ + SRK + V++ S
Sbjct: 888 YNELRGQLEECRGRWALRLCLEERDWLPGKTLFENL-WASVYGSRKTLFVLAHTDRVSGL 946
Query: 747 CIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVELYRLLSRNTYLEWEDSVLGRHI 806
+ +AQ + L R ++ +V+ + R V L + L R + L W G+
Sbjct: 947 LRASFLLAQQ-RLLEDRKDVVVLVILSPDGRRSRY-VRLRQRLCRQSVLLWPHQPSGQRS 1004
Query: 807 FWRRLRKAL 815
FW +L AL
Sbjct: 1005 FWAQLGMAL 1013
Score = 53.1 bits (126), Expect = 1e-06
Identities = 70/258 (27%), Positives = 107/258 (41%), Gaps = 52/258 (20%)
Query: 337 LVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDF 396
LVNC + L LKS+ + + +G ++ L LS N + SDF
Sbjct: 42 LVNCNW-----LFLKSVPHFSMAAPRG----------NVTSLSLSSNRIHH---LHDSDF 83
Query: 397 G-TTSLKYLDLSFN----GVITMS---------SNFLGLEQLEHLDFQHSNLKQMSEFSV 442
SL++L+L +N G+ M S FL + LE L+ ++N+ +
Sbjct: 84 AHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALP- 142
Query: 443 FLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQEN-------FLPDIFTEL 495
++LI L +SHT+ + + GL +L L M GN + +N P L
Sbjct: 143 ----KSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGL 198
Query: 496 RNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLN- 554
NLT L L + L+ N SSL+ L +S+N L L +L+VLD N
Sbjct: 199 GNLTHLSL---KYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNC 255
Query: 555 ----HIMTSKKQELQHFP 568
H + +HFP
Sbjct: 256 RRCDHAPNPCMECPRHFP 273
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 92.4 bits (228), Expect = 2e-18
Identities = 69/212 (32%), Positives = 107/212 (50%), Gaps = 6/212 (2%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C F +P+ +P T+ LDL N ++ L F SFP L+ L+L+ + +E GA+
Sbjct: 57 CHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFN 116
Query: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
+L +L TL L N ++ + LG F+GLS+L KL E + L ++ L LK L V
Sbjct: 117 NLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGD 176
Query: 160 NLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQ 219
N + + FS L +LE L L + SI L LH + +L L LN +N I+
Sbjct: 177 NDL-VYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLR---HLN-INAIR 231
Query: 220 PGAFKEIRLHKLTLRNNFDSLNVM-KTCIQGL 250
+FK + K+ +++ L+ M C+ GL
Sbjct: 232 DYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL 263
Score = 65.1 bits (157), Expect = 3e-10
Identities = 64/244 (26%), Positives = 107/244 (43%), Gaps = 33/244 (13%)
Query: 400 SLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 458
+LK L++ N ++ +S F GL LE L + NL + L LI L + H +
Sbjct: 168 NLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPT-EALSHLHGLIVLRLRHLN 226
Query: 459 TRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNS 518
+ F L L+VL+++ + + P+ L NLT L ++ C L + A
Sbjct: 227 INAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL-NLTSLSITHCNLTAVPYLAVRH 285
Query: 519 LSSLQVLNMSHNNFFSL------------------------DTFPYKCLNSLQVLDYSLN 554
L L+ LN+S+N ++ + + ++ LN L+VL+ S N
Sbjct: 286 LVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGN 345
Query: 555 HIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQR-QLLVEVERMECATPS 613
+T+ ++ + H +L L L N AC C L W+ +R +L ++ CATP
Sbjct: 346 Q-LTTLEESVFHSVGNLETLILDSNPLACDCR----LLWVFRRRWRLNFNRQQPTCATPE 400
Query: 614 DKQG 617
QG
Sbjct: 401 FVQG 404
Score = 48.1 bits (113), Expect = 3e-05
Identities = 49/201 (24%), Positives = 91/201 (45%), Gaps = 6/201 (2%)
Query: 427 LDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQEN 486
LD + +K +++ F S +L L+++ G FN L +L L + N +
Sbjct: 76 LDLGKNRIKTLNQ-DEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLK-- 132
Query: 487 FLP-DIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNS 545
+P +FT L NLT LD+S+ ++ L F L +L+ L + N+ + + LNS
Sbjct: 133 LIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNS 192
Query: 546 LQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVE 605
L+ L ++ + + L H L L L + ++ SF + + + +
Sbjct: 193 LEQLTLEKCNLTSIPTEALSHL-HGLIVLRLRHLNINAIRDY-SFKRLYRLKVLEISHWP 250
Query: 606 RMECATPSDKQGMPVLSLNIT 626
++ TP+ G+ + SL+IT
Sbjct: 251 YLDTMTPNCLYGLNLTSLSIT 271
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/108 (29%), Positives = 53/108 (49%), Gaps = 1/108 (0%)
Query: 80 LQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLA 139
L L ++ C + + A + L +L L L+ NPI ++ L LQ++ V LA
Sbjct: 265 LTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLA 324
Query: 140 SLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKI 187
+E + L L+ LNV+ N + + + F ++ NLE L L SN +
Sbjct: 325 VVEPYAFRGLNYLRVLNVSGNQLTTLE-ESVFHSVGNLETLILDSNPL 371
Score = 38.9 bits (89), Expect = 0.020
Identities = 21/81 (25%), Positives = 41/81 (50%)
Query: 59 LDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLA 118
L+LS+NP+ + LQ + L ++ +E A++ L++L L ++GN + +L
Sbjct: 292 LNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLE 351
Query: 119 LGAFSGLSSLQKLVAVETNLA 139
F + +L+ L+ LA
Sbjct: 352 ESVFHSVGNLETLILDSNPLA 372
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 89.4 bits (220), Expect = 1e-17
Identities = 136/528 (25%), Positives = 216/528 (40%), Gaps = 95/528 (17%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C N ++PD +P T+ L L N L + +F + L L+L ++ ++E A
Sbjct: 98 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 157
Query: 100 SLSHLSTLILTGNPIQSLALGAFS------------------------GLSSLQKLVAVE 135
L +L L L N ++SLALG F+ GL SL L
Sbjct: 158 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 217
Query: 136 TNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDL 195
+LA L + L +L+EL +A N + ++ P FS L L LDLS N +++I
Sbjct: 218 NSLAVLPDAAFRGLGSLRELVLAGNRL-AYLQPALFSGLAELRELDLSRNALRAIKAN-- 274
Query: 196 RVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIR-LHKLTLRNNFDSLNVMKTCIQGLAGLE 254
V Q+P L L L N + + PGAF ++ L L L +N + +++ GL GL
Sbjct: 275 -VFVQLPRLQ-KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVA-GLLEDTFPGLLGLR 331
Query: 255 VHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFS 314
V RL +A+ L T ++ ++L+++
Sbjct: 332 VLRL--------------SHNAIASLRPRTFKDL------HFLEEL-------------Q 358
Query: 315 LVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS--NKGGNAFSEVDL 372
L I ++ + S+ G LE++ Q +K + LT + N GN +L
Sbjct: 359 LGHNRIRQLAERSFE-GLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR--NL 415
Query: 373 PSLEFLDLSR-NGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQH 431
P F L + + L +G C F GL L L +
Sbjct: 416 PEQVFRGLGKLHSLHLEGSCLGR------------------IRPHTFTGLSGLRRLFLKD 457
Query: 432 SNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLP-D 490
+ L + E S++ L L+ LD++ + +F GL LE L ++ N E LP D
Sbjct: 458 NGLVGIEEQSLW-GLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAE--LPAD 514
Query: 491 IFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 538
L+ +LD+S +LE L + L L+ L++ +N SL TF
Sbjct: 515 ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNN---SLRTF 559
Score = 60.5 bits (145), Expect = 6e-09
Identities = 85/326 (26%), Positives = 127/326 (38%), Gaps = 29/326 (8%)
Query: 235 NNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLD 294
NN S V Q L+ L L G+ G+LE LE LC+L +E +L L
Sbjct: 122 NNLSS--VPPAAFQNLSSLGFLNLQGGQL---GSLEPQALLGLENLCHLHLERNQLRSL- 175
Query: 295 YYLDDIIDLFNCLTNVSSFSLVSVTIERVKD---------FSYNFGWQHLELVNCKFGQF 345
+ F ++S L + + R++D + N GW L ++
Sbjct: 176 -----ALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP----DA 226
Query: 346 PTLKLKSLKRLTFTSNKGGNAFSEV--DLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKY 403
L SL+ L N+ + L L LDLSRN L Y
Sbjct: 227 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 286
Query: 404 LDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAF 463
LD + + + FLGL+ L LD H+ + + E F L L L +SH
Sbjct: 287 LDRNLIAAVAPGA-FLGLKALRWLDLSHNRVAGLLE-DTFPGLLGLRVLRLSHNAIASLR 344
Query: 464 NGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQ 523
F L LE L++ N ++ F L L L L QL+++ AF L+++
Sbjct: 345 PRTFKDLHFLEELQLGHNRIRQ-LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 403
Query: 524 VLNMSHNNFFSLDTFPYKCLNSLQVL 549
V+N+S N +L ++ L L L
Sbjct: 404 VMNLSGNCLRNLPEQVFRGLGKLHSL 429
Score = 57.8 bits (138), Expect = 4e-08
Identities = 66/230 (28%), Positives = 95/230 (41%), Gaps = 26/230 (11%)
Query: 373 PSLEFLDLSRNGLS------FKGCCSQSDF--GTTSLKYL-DLSFNGV-----ITMSSN- 417
P+L L LS N LS F+G S D G SL L D +F G+ + ++ N
Sbjct: 184 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNR 243
Query: 418 --------FLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNG 469
F GL +L LD + L+ + +VF+ L L L + G F G
Sbjct: 244 LAYLQPALFSGLAELRELDLSRNALRAIKA-NVFVQLPRLQKLYLDRNLIAAVAPGAFLG 302
Query: 470 LSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSH 529
L +L L ++ N L D F L L L LS + L P F L L+ L + H
Sbjct: 303 LKALRWLDLSHNRVA-GLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGH 361
Query: 530 NNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQN 579
N L ++ L L+VL N + K +++A +NL+ N
Sbjct: 362 NRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGL-TNVAVMNLSGN 410
Score = 36.2 bits (82), Expect = 0.13
Identities = 50/183 (27%), Positives = 77/183 (42%), Gaps = 17/183 (9%)
Query: 439 EFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNL 498
E SVF S RNL L +G+ G + L + GN+ + P F L +L
Sbjct: 93 ELSVFCSSRNLTRLP----------DGVPGGT---QALWLDGNNLS-SVPPAAFQNLSSL 138
Query: 499 TFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMT 558
FL+L QL L P A L +L L++ N SL + +L L S N+ ++
Sbjct: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLS-NNRLS 197
Query: 559 SKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGM 618
+ L SL LNL N A + + + + R+L++ R+ P+ G+
Sbjct: 198 RLEDGLFEGLGSLWDLNLGWNSLAVLPD--AAFRGLGSLRELVLAGNRLAYLQPALFSGL 255
Query: 619 PVL 621
L
Sbjct: 256 AEL 258
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 89.4 bits (220), Expect = 1e-17
Identities = 136/528 (25%), Positives = 216/528 (40%), Gaps = 95/528 (17%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C N ++PD +P T+ L L N L + +F + L L+L ++ ++E A
Sbjct: 60 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119
Query: 100 SLSHLSTLILTGNPIQSLALGAFS------------------------GLSSLQKLVAVE 135
L +L L L N ++SLALG F+ GL SL L
Sbjct: 120 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 179
Query: 136 TNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDL 195
+LA L + L +L+EL +A N + ++ P FS L L LDLS N +++I
Sbjct: 180 NSLAVLPDAAFRGLGSLRELVLAGNRL-AYLQPALFSGLAELRELDLSRNALRAIKAN-- 236
Query: 196 RVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIR-LHKLTLRNNFDSLNVMKTCIQGLAGLE 254
V Q+P L L L N + + PGAF ++ L L L +N + +++ GL GL
Sbjct: 237 -VFVQLPRLQ-KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVA-GLLEDTFPGLLGLR 293
Query: 255 VHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFS 314
V RL +A+ L T ++ ++L+++
Sbjct: 294 VLRL--------------SHNAIASLRPRTFKDL------HFLEEL-------------Q 320
Query: 315 LVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTS--NKGGNAFSEVDL 372
L I ++ + S+ G LE++ Q +K + LT + N GN +L
Sbjct: 321 LGHNRIRQLAERSFE-GLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR--NL 377
Query: 373 PSLEFLDLSR-NGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQH 431
P F L + + L +G C F GL L L +
Sbjct: 378 PEQVFRGLGKLHSLHLEGSCLGR------------------IRPHTFTGLSGLRRLFLKD 419
Query: 432 SNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLP-D 490
+ L + E S++ L L+ LD++ + +F GL LE L ++ N E LP D
Sbjct: 420 NGLVGIEEQSLW-GLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAE--LPAD 476
Query: 491 IFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTF 538
L+ +LD+S +LE L + L L+ L++ +N SL TF
Sbjct: 477 ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNN---SLRTF 521
Score = 60.5 bits (145), Expect = 6e-09
Identities = 85/326 (26%), Positives = 127/326 (38%), Gaps = 29/326 (8%)
Query: 235 NNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLD 294
NN S V Q L+ L L G+ G+LE LE LC+L +E +L L
Sbjct: 84 NNLSS--VPPAAFQNLSSLGFLNLQGGQL---GSLEPQALLGLENLCHLHLERNQLRSL- 137
Query: 295 YYLDDIIDLFNCLTNVSSFSLVSVTIERVKD---------FSYNFGWQHLELVNCKFGQF 345
+ F ++S L + + R++D + N GW L ++
Sbjct: 138 -----ALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP----DA 188
Query: 346 PTLKLKSLKRLTFTSNKGGNAFSEV--DLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKY 403
L SL+ L N+ + L L LDLSRN L Y
Sbjct: 189 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 248
Query: 404 LDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAF 463
LD + + + FLGL+ L LD H+ + + E F L L L +SH
Sbjct: 249 LDRNLIAAVAPGA-FLGLKALRWLDLSHNRVAGLLE-DTFPGLLGLRVLRLSHNAIASLR 306
Query: 464 NGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQ 523
F L LE L++ N ++ F L L L L QL+++ AF L+++
Sbjct: 307 PRTFKDLHFLEELQLGHNRIRQ-LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 365
Query: 524 VLNMSHNNFFSLDTFPYKCLNSLQVL 549
V+N+S N +L ++ L L L
Sbjct: 366 VMNLSGNCLRNLPEQVFRGLGKLHSL 391
Score = 57.8 bits (138), Expect = 4e-08
Identities = 66/230 (28%), Positives = 95/230 (41%), Gaps = 26/230 (11%)
Query: 373 PSLEFLDLSRNGLS------FKGCCSQSDF--GTTSLKYL-DLSFNGV-----ITMSSN- 417
P+L L LS N LS F+G S D G SL L D +F G+ + ++ N
Sbjct: 146 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNR 205
Query: 418 --------FLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNG 469
F GL +L LD + L+ + +VF+ L L L + G F G
Sbjct: 206 LAYLQPALFSGLAELRELDLSRNALRAIKA-NVFVQLPRLQKLYLDRNLIAAVAPGAFLG 264
Query: 470 LSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSH 529
L +L L ++ N L D F L L L LS + L P F L L+ L + H
Sbjct: 265 LKALRWLDLSHNRVA-GLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGH 323
Query: 530 NNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQN 579
N L ++ L L+VL N + K +++A +NL+ N
Sbjct: 324 NRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGL-TNVAVMNLSGN 372
Score = 36.2 bits (82), Expect = 0.13
Identities = 50/183 (27%), Positives = 77/183 (42%), Gaps = 17/183 (9%)
Query: 439 EFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNL 498
E SVF S RNL L +G+ G + L + GN+ + P F L +L
Sbjct: 55 ELSVFCSSRNLTRLP----------DGVPGGT---QALWLDGNNLS-SVPPAAFQNLSSL 100
Query: 499 TFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMT 558
FL+L QL L P A L +L L++ N SL + +L L S N+ ++
Sbjct: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLS-NNRLS 159
Query: 559 SKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGM 618
+ L SL LNL N A + + + + R+L++ R+ P+ G+
Sbjct: 160 RLEDGLFEGLGSLWDLNLGWNSLAVLPD--AAFRGLGSLRELVLAGNRLAYLQPALFSGL 217
Query: 619 PVL 621
L
Sbjct: 218 AEL 220
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 89.0 bits (219), Expect = 2e-17
Identities = 65/212 (30%), Positives = 112/212 (52%), Gaps = 18/212 (8%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C+ N ++PD + +T+ L+L N ++ + SF L++L LSR I+TIE GA+
Sbjct: 62 CVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFN 121
Query: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
L++L+TL L N + ++ GAF LS L++L + S+ ++ + +L+ L++
Sbjct: 122 GLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGE 181
Query: 160 NLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNL-SLDLSLNPMNFI 218
S+ F L+NL +L+L+ C + + PL+ L LDLS N ++ I
Sbjct: 182 LKRLSYISEGAFEGLSNLRYLNLA-------MCNLREIPNLTPLIKLDELDLSGNHLSAI 234
Query: 219 QPGAFKEI-RLHKLTL---------RNNFDSL 240
+PG+F+ + L KL + RN FD+L
Sbjct: 235 RPGSFQGLMHLQKLWMIQSQIQVIERNAFDNL 266
Score = 63.5 bits (153), Expect = 8e-10
Identities = 47/153 (30%), Positives = 77/153 (50%), Gaps = 26/153 (16%)
Query: 57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCE-IQTIEDGAYQSLSHL----------- 104
K L L NP+ + SY+F P L+ LDL + + I +GA++ LS+L
Sbjct: 151 KELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLR 210
Query: 105 -----------STLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLK 153
L L+GN + ++ G+F GL LQKL +++ + +E +L++L
Sbjct: 211 EIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLV 270
Query: 154 ELNVAHNLIQSFKLP-EYFSNLTNLEHLDLSSN 185
E+N+AHN + LP + F+ L +LE + L N
Sbjct: 271 EINLAHNNLT--LLPHDLFTPLHHLERIHLHHN 301
Score = 48.9 bits (115), Expect = 2e-05
Identities = 55/201 (27%), Positives = 85/201 (42%), Gaps = 33/201 (16%)
Query: 399 TSLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLKQMSEFS--VFLSLRNLIYLDIS 455
+ LK L L N + ++ S F + L LD LK++S S F L NL YL+++
Sbjct: 148 SKLKELWLRNNPIESIPSYAFNRIPSLRRLDL--GELKRLSYISEGAFEGLSNLRYLNLA 205
Query: 456 HTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTA 515
+ R N L L+ L ++GN P F L +L L + Q Q++ + A
Sbjct: 206 MCNLREIPN--LTPLIKLDELDLSGNHLSA-IRPGSFQGLMHLQKLWMIQSQIQVIERNA 262
Query: 516 FNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLN 575
F++L SL +N++HNN L P+ L L+ ++
Sbjct: 263 FDNLQSLVEINLAHNN---LTLLPHDLFTPLHHLER----------------------IH 297
Query: 576 LTQNDFACTCEHQSFLQWIKD 596
L N + C C+ WIKD
Sbjct: 298 LHHNPWNCNCDILWLSWWIKD 318
Score = 46.6 bits (109), Expect = 1e-04
Identities = 43/159 (27%), Positives = 65/159 (40%), Gaps = 26/159 (16%)
Query: 431 HSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQ------ 484
H N Q+ + + F LR+L L +S H R G FNGL++L L++ N
Sbjct: 84 HENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGA 143
Query: 485 -----------------ENFLPDIFTELRNLTFLDLSQC-QLEQLSPTAFNSLSSLQVLN 526
E+ F + +L LDL + +L +S AF LS+L+ LN
Sbjct: 144 FVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLN 203
Query: 527 MSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQ 565
++ N + L L LD S NH+ + Q
Sbjct: 204 LAMCNLREIPNL--TPLIKLDELDLSGNHLSAIRPGSFQ 240
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 88.6 bits (218), Expect = 2e-17
Identities = 119/428 (27%), Positives = 176/428 (41%), Gaps = 71/428 (16%)
Query: 48 IPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTL 107
+P +LP T++L+LS+N L + F P LQ + L+ E+ + S SH+ +L
Sbjct: 62 LPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAAS-SHVVSL 120
Query: 108 ILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKL 167
L N I+S+ SL+ L N+ + N H +KELN+A N I + +L
Sbjct: 121 FLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLEL 180
Query: 168 PEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIR 227
+ +L L LS N+I Q+P+ AFK R
Sbjct: 181 GAFDGLSRSLLTLRLSKNRIT-----------QLPV-----------------RAFKLPR 212
Query: 228 LHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEE 287
L +L L N L + QGL LEV +L N+ K A GL +
Sbjct: 213 LTQLDLNRNRIRL-IEGLTFQGLNSLEVLKL------QRNNISKLTDGAFWGL-----SK 260
Query: 288 FRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNF-------GW---QHLEL 337
+ +L+Y N L V+S SL +T S N GW Q L
Sbjct: 261 MHVLHLEY---------NSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHE 311
Query: 338 VNCKFGQFPTLKLKSLKRLTFTS--NKGGNAFSEV------DLPSLEFLDLSRNGLSFKG 389
+ F L +SL L+ S N+ S + L SL LDL N +S
Sbjct: 312 LVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTI 371
Query: 390 CCSQSDF-GTTSLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLKQMSEFSVFLSLR 447
+ F G SL L L N + +++ F GLE LEHL+ + ++ + +F F+ ++
Sbjct: 372 EDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSV-QFDAFVKMK 430
Query: 448 NLIYLDIS 455
NL L IS
Sbjct: 431 NLKELHIS 438
Score = 62.0 bits (149), Expect = 2e-09
Identities = 100/463 (21%), Positives = 175/463 (37%), Gaps = 86/463 (18%)
Query: 201 MPLLNLSLDLSLNPMNFIQPGAFKEI-RLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLV 259
+P SL+LS N ++ I P F+++ L ++ L NN T + L H V
Sbjct: 66 LPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNN------ELTAVPSLGAASSH--V 117
Query: 260 LGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFN-CLTNVSSFSLVSV 318
+ F + + S L+ +L + LD L++I ++ N C + +++
Sbjct: 118 VSLFLQHNKIRSVEGSQLKAYLSLEV-------LDLSLNNITEVRNTCFPHGPPIKELNL 170
Query: 319 TIERVKDFSYNF------GWQHLELVNCKFGQFPT--LKLKSLKRLTFTSNK----GGNA 366
R+ L L + Q P KL L +L N+ G
Sbjct: 171 AGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLT 230
Query: 367 FSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFL-GLEQLE 425
F L SLE L L RN +S + +G + + L L +N ++ ++S L GL L
Sbjct: 231 FQ--GLNSLEVLKLQRNNIS--KLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALH 286
Query: 426 HLDFQHSNLKQMSE---------FSVFLSLRNLIYLD--------------ISHTHTRVA 462
L ++++ ++ + LS NL LD +SH
Sbjct: 287 QLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHI 346
Query: 463 FNGIFNGLSSLEVLKMAGNSFQENF--LPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLS 520
G F GL SL VL + N F+ L +L+ L L +++ ++ AF+ L
Sbjct: 347 AEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLE 406
Query: 521 SLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQND 580
L+ LN+ N S+ + + +L+ L+++ +
Sbjct: 407 GLEHLNLGGNAIRSVQFDAFVKMKNLKE-------------------------LHISSDS 441
Query: 581 FACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSL 623
F C C+ + W+ ++L CA P +G + S+
Sbjct: 442 FLCDCQLKWLPPWLIG--RMLQAFVTATCAHPESLKGQSIFSV 482
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 87.8 bits (216), Expect = 4e-17
Identities = 61/181 (33%), Positives = 92/181 (50%), Gaps = 2/181 (1%)
Query: 35 NITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIE 94
N + C IP+ +P TK LDLS N L+ + F S+P L+ +DLS I +E
Sbjct: 38 NKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVE 97
Query: 95 DGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKE 154
GA+ +L +L +L L GN ++ + LG F+GLS+L KL E + L ++ L LK
Sbjct: 98 PGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKS 157
Query: 155 LNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNP 214
L V N + + FS L +LE L L + ++ L L + L+L L++N
Sbjct: 158 LEVGDNDL-VYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLK-HLNINN 215
Query: 215 M 215
M
Sbjct: 216 M 216
Score = 67.0 bits (162), Expect = 7e-11
Identities = 117/458 (25%), Positives = 189/458 (41%), Gaps = 91/458 (19%)
Query: 180 LDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDS 239
LDLS N+++S+ + PLL +DLS N + ++PGAF NN +
Sbjct: 62 LDLSKNRLKSVNPEEFI---SYPLLE-EIDLSDNIIANVEPGAF-----------NNLFN 106
Query: 240 LNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDD 299
L ++ L G + + LG F NL K D S E + LDY D
Sbjct: 107 LRSLR-----LKGNRLKLVPLGVFTGLSNLTKLDIS----------ENKIVILLDYMFQD 151
Query: 300 IIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFT 359
+ +L + V LV ++ + FS + L L C PT L L+ L
Sbjct: 152 LHNLKS--LEVGDNDLVYIS---HRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLI-- 204
Query: 360 SNKGGNAFSEVDLPSLEFLDLSRNGL---SFKGCCSQSDFGTTSLKYLDLSFNGVITM-- 414
SL L+ N + +FK LK+L++ + ++ M
Sbjct: 205 --------------SLHLKHLNINNMPVYAFK--------RLFHLKHLEIDYWPLLDMMP 242
Query: 415 SSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFN-------GIF 467
+++ GL L L ++NL + FL+ ++L+YL TH +++N G+F
Sbjct: 243 ANSLYGL-NLTSLSVTNTNLSTVP----FLAFKHLVYL----THLNLSYNPISTIEAGMF 293
Query: 468 NGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNM 527
+ L L+ L + G + P F LR L L++SQ LE L F+S +L+VL++
Sbjct: 294 SDLIRLQELHIVGAQLR-TIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSI 352
Query: 528 SHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEH 587
+NN + D L L + M + ++ S + T F TC+
Sbjct: 353 -NNNPLACDCRLLWILQRQPTLQFGGQQPMCAGPDTIRE--RSFKDFHSTALSFYFTCKK 409
Query: 588 QSFLQWIKDQRQLLV---EVERMECATPSDKQGMPVLS 622
+ K + LLV + ++EC+ D Q PV+S
Sbjct: 410 PKIRE--KKLQHLLVDEGQTVQLECSADGDPQ--PVIS 443
Score = 60.1 bits (144), Expect = 8e-09
Identities = 44/151 (29%), Positives = 79/151 (52%), Gaps = 2/151 (1%)
Query: 54 FSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNP 113
F K+L++ + PL + + L L ++ + T+ A++ L +L+ L L+ NP
Sbjct: 225 FHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNP 284
Query: 114 IQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSN 173
I ++ G FS L LQ+L V L ++E L+ L+ LNV+ NL+++ + FS+
Sbjct: 285 ISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLE-ENVFSS 343
Query: 174 LTNLEHLDLSSNKIQSIYCTDLRVLHQMPLL 204
LE L +++N + + C L +L + P L
Sbjct: 344 PRALEVLSINNNPL-ACDCRLLWILQRQPTL 373
Score = 52.8 bits (125), Expect = 1e-06
Identities = 58/204 (28%), Positives = 89/204 (43%), Gaps = 13/204 (6%)
Query: 376 EFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNL 434
+ LDLS+N L K + L+ +DLS N + + F L L L + + L
Sbjct: 60 KILDLSKNRL--KSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRL 117
Query: 435 KQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTE 494
K + VF L NL LDIS + + +F L +L+ L++ N F+
Sbjct: 118 K-LVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVY-ISHRAFSG 175
Query: 495 LRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLN 554
L +L L L +C L + A + L SL L++ H N ++ + +K L + L
Sbjct: 176 LLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRL-------FHLK 228
Query: 555 HIMTSKKQELQHFP-SSLAFLNLT 577
H+ L P +SL LNLT
Sbjct: 229 HLEIDYWPLLDMMPANSLYGLNLT 252
Score = 51.6 bits (122), Expect = 3e-06
Identities = 54/195 (27%), Positives = 88/195 (45%), Gaps = 48/195 (24%)
Query: 59 LDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLA 118
LD+S N + L Y F Q L +L +L + N + ++
Sbjct: 134 LDISENKIVILLDYMF------------------------QDLHNLKSLEVGDNDLVYIS 169
Query: 119 LGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEY-FSNLTNL 177
AFSGL SL++L + NL ++ + HL++L L++ H I + +P Y F L +L
Sbjct: 170 HRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINN--MPVYAFKRLFHL 227
Query: 178 EHLDLS---------SNKIQSIYCTDLRV----LHQMPLLNLS-------LDLSLNPMNF 217
+HL++ +N + + T L V L +P L L+LS NP++
Sbjct: 228 KHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPIST 287
Query: 218 IQPGAFKE-IRLHKL 231
I+ G F + IRL +L
Sbjct: 288 IEAGMFSDLIRLQEL 302
Score = 45.1 bits (105), Expect = 3e-04
Identities = 47/205 (22%), Positives = 87/205 (42%), Gaps = 30/205 (14%)
Query: 57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQS 116
K+L++ N L ++ +F L+ L L +C + + A L L +L L I +
Sbjct: 156 KSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINN 215
Query: 117 LALGAFSGLSSLQ------------------------KLVAVETNLASLENFPIGHLKTL 152
+ + AF L L+ L TNL+++ HL L
Sbjct: 216 MPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYL 275
Query: 153 KELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSL 212
LN+++N I + + FS+L L+ L + ++++I + L + +LN+S +L
Sbjct: 276 THLNLSYNPISTIEAG-MFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNL-- 332
Query: 213 NPMNFIQPGAFKEIR-LHKLTLRNN 236
+ ++ F R L L++ NN
Sbjct: 333 --LETLEENVFSSPRALEVLSINNN 355
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 85.5 bits (210), Expect = 2e-16
Identities = 151/581 (25%), Positives = 245/581 (42%), Gaps = 82/581 (14%)
Query: 28 PCVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSR 87
PC V ++ C L ++P LP T+ LDLS N LR + + + L+ LDLS
Sbjct: 25 PCKMVDKKVS--CQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLST 82
Query: 88 CEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETN----LASLEN 143
EI ++ GA+Q+L+HL L L N + + GL L ++ +++ + + L
Sbjct: 83 NEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLE 142
Query: 144 FPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPL 203
+G +L L++A N + F ++ LE LDL SN + I L ++
Sbjct: 143 RLLGEAPSLHTLSLAENSLTRL-TRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTH 201
Query: 204 LNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEF 263
LN LS N + I + +++R+ L+ +S+ +T Q A ++ L +
Sbjct: 202 LN----LSRNSLTCISDFSLQQLRVLDLSC----NSIEAFQTASQPQAEFQLTWL---DL 250
Query: 264 RNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERV 323
R L D +AL RL YL+ S +L+ +
Sbjct: 251 RENKLLHFPDLAALP----------RLIYLNL----------------SNNLIRLPTGPP 284
Query: 324 KD----FSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNK---GGNAFSEVDLPSLE 376
+D + + GW L L + G L L L + N+ ++F E L SL
Sbjct: 285 QDSKGIHAPSEGWSALPL-SAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLE-HLTSLC 342
Query: 377 FLDLSRNGL-SFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLK 435
FL+LSRN L +F+ ++ L LDLS N + T+ L L L Q + L+
Sbjct: 343 FLNLSRNCLRTFE---ARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALR 399
Query: 436 QMSEFSVFLSLRNLIYLDISHTHTRVAFNG-----------IFNGLSSLEVLKMAGNSFQ 484
+ ++ F +L +L L++ RV+ G F+G++SL L + N
Sbjct: 400 DLPPYT-FANLASLQRLNLQ--GNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEI- 455
Query: 485 ENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSL-SSLQVLNMSHNNFFSL--DTFPYK 541
E F LT LDLS +++ A L +SL+VL + N L D +
Sbjct: 456 ELLRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFI 514
Query: 542 CLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFA 582
CL L + + L+H+ + SL L+L N F+
Sbjct: 515 CLKRLNLAENRLSHLPAWTQ------AVSLEVLDLRNNSFS 549
Score = 53.5 bits (127), Expect = 8e-07
Identities = 79/307 (25%), Positives = 131/307 (42%), Gaps = 32/307 (10%)
Query: 28 PCVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHL------GSYSFFSFPELQ 81
P + +P + Y + N ++P P +K + L G+ S +L
Sbjct: 259 PDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLL 318
Query: 82 VLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASL 141
LDLS EI+ I D + L+ L L L+ N +++ L SL L+ ++ + +L
Sbjct: 319 NLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEA---RRLGSLPCLMLLDLSHNAL 375
Query: 142 ENFPIG--HLKTLKELNVAHNLIQSFKLPEY-FSNLTNLEHLDLSSNKIQSIYCTDLR-- 196
E +G L +L+ L + N ++ LP Y F+NL +L+ L+L N++ D
Sbjct: 376 ETLELGARALGSLRTLLLQGNALRD--LPPYTFANLASLQRLNLQGNRVSPCGGPDEPGP 433
Query: 197 ---VLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGL 253
V SL L N + ++ GAF L +L L +N ++ L GL
Sbjct: 434 SGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSN----PGLEVATGALGGL 489
Query: 254 EVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLD----DIIDLFNCLTN 309
E VL N + + D L L + E RL++L + +++DL N
Sbjct: 490 EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRN---- 545
Query: 310 VSSFSLV 316
+SFSL+
Sbjct: 546 -NSFSLL 551
Score = 37.0 bits (84), Expect = 0.076
Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 474 EVLKMAGNSFQENFLPDI--FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNN 531
E L ++GN + + +T LR+L DLS ++ L P AF +L+ L+ L+++HN
Sbjct: 52 ETLDLSGNQLRSILASPLGFYTALRHL---DLSTNEISFLQPGAFQALTHLEHLSLAHNR 108
Query: 532 F---FSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEH 587
+L L + LD S N + + + L SL L+L +N H
Sbjct: 109 LAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRH 167
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 85.5 bits (210), Expect = 2e-16
Identities = 151/581 (25%), Positives = 245/581 (42%), Gaps = 82/581 (14%)
Query: 28 PCVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSR 87
PC V ++ C L ++P LP T+ LDLS N LR + + + L+ LDLS
Sbjct: 25 PCKMVDKKVS--CQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLST 82
Query: 88 CEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETN----LASLEN 143
EI ++ GA+Q+L+HL L L N + + GL L ++ +++ + + L
Sbjct: 83 NEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLE 142
Query: 144 FPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPL 203
+G +L L++A N + F ++ LE LDL SN + I L ++
Sbjct: 143 RLLGEAPSLHTLSLAENSLTRL-TRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTH 201
Query: 204 LNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEF 263
LN LS N + I + +++R+ L+ +S+ +T Q A ++ L +
Sbjct: 202 LN----LSRNSLTCISDFSLQQLRVLDLSC----NSIEAFQTASQPQAEFQLTWL---DL 250
Query: 264 RNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERV 323
R L D +AL RL YL+ S +L+ +
Sbjct: 251 RENKLLHFPDLAALP----------RLIYLNL----------------SNNLIRLPTGPP 284
Query: 324 KD----FSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNK---GGNAFSEVDLPSLE 376
+D + + GW L L + G L L L + N+ ++F E L SL
Sbjct: 285 QDSKGIHAPSEGWSALPL-SAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLE-HLTSLC 342
Query: 377 FLDLSRNGL-SFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLK 435
FL+LSRN L +F+ ++ L LDLS N + T+ L L L Q + L+
Sbjct: 343 FLNLSRNCLRTFE---ARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALR 399
Query: 436 QMSEFSVFLSLRNLIYLDISHTHTRVAFNG-----------IFNGLSSLEVLKMAGNSFQ 484
+ ++ F +L +L L++ RV+ G F+G++SL L + N
Sbjct: 400 DLPPYT-FANLASLQRLNLQ--GNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEI- 455
Query: 485 ENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSL-SSLQVLNMSHNNFFSL--DTFPYK 541
E F LT LDLS +++ A L +SL+VL + N L D +
Sbjct: 456 ELLRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFI 514
Query: 542 CLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFA 582
CL L + + L+H+ + SL L+L N F+
Sbjct: 515 CLKRLNLAENRLSHLPAWTQ------AVSLEVLDLRNNSFS 549
Score = 53.5 bits (127), Expect = 8e-07
Identities = 79/307 (25%), Positives = 131/307 (42%), Gaps = 32/307 (10%)
Query: 28 PCVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHL------GSYSFFSFPELQ 81
P + +P + Y + N ++P P +K + L G+ S +L
Sbjct: 259 PDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLL 318
Query: 82 VLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASL 141
LDLS EI+ I D + L+ L L L+ N +++ L SL L+ ++ + +L
Sbjct: 319 NLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEA---RRLGSLPCLMLLDLSHNAL 375
Query: 142 ENFPIG--HLKTLKELNVAHNLIQSFKLPEY-FSNLTNLEHLDLSSNKIQSIYCTDLR-- 196
E +G L +L+ L + N ++ LP Y F+NL +L+ L+L N++ D
Sbjct: 376 ETLELGARALGSLRTLLLQGNALRD--LPPYTFANLASLQRLNLQGNRVSPCGGPDEPGP 433
Query: 197 ---VLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGL 253
V SL L N + ++ GAF L +L L +N ++ L GL
Sbjct: 434 SGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSN----PGLEVATGALGGL 489
Query: 254 EVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLD----DIIDLFNCLTN 309
E VL N + + D L L + E RL++L + +++DL N
Sbjct: 490 EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRN---- 545
Query: 310 VSSFSLV 316
+SFSL+
Sbjct: 546 -NSFSLL 551
Score = 37.0 bits (84), Expect = 0.076
Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 474 EVLKMAGNSFQENFLPDI--FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNN 531
E L ++GN + + +T LR+L DLS ++ L P AF +L+ L+ L+++HN
Sbjct: 52 ETLDLSGNQLRSILASPLGFYTALRHL---DLSTNEISFLQPGAFQALTHLEHLSLAHNR 108
Query: 532 F---FSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEH 587
+L L + LD S N + + + L SL L+L +N H
Sbjct: 109 LAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRH 167
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 83.6 bits (205), Expect = 7e-16
Identities = 111/450 (24%), Positives = 184/450 (40%), Gaps = 65/450 (14%)
Query: 39 QCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAY 98
+C +P LP++ +L + + L F + L L + + E+ I GA+
Sbjct: 44 ECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAF 103
Query: 99 QSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVA 158
++L L L L N +Q L +G F GL SL+ L+ L ++ LKEL +
Sbjct: 104 RNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLH 163
Query: 159 HNLIQSFKLPE-YFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNF 217
N ++ +P+ F +L L L+L N + I RV + L + L L N +
Sbjct: 164 GNHLE--YIPDGAFDHLVGLTKLNLGKNSLTHI---SPRVFQHLGNLQV-LRLYENRLTD 217
Query: 218 IQPGAFKE-IRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSA 276
I G F + L +L L+ N ++ L G F N NL++
Sbjct: 218 IPMGTFDGLVNLQELALQQN-----------------QIGLLSPGLFHNNHNLQR----- 255
Query: 277 LEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLE 336
L + ++ L +F L ++ +L FG E
Sbjct: 256 ------LYLSNNHISQLP------PSIFMQLPQLNRLTL--------------FGNSLKE 289
Query: 337 LVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDF 396
L FG P L+ L S+ N FS +L L+ L LSRN +SF S F
Sbjct: 290 LSLGIFGPMPNLRELWLYD-NHISSLPDNVFS--NLRQLQVLILSRNQISF---ISPGAF 343
Query: 397 -GTTSLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDI 454
G T L+ L L N + + N F L L+++ Q++ L+Q+ ++F ++ L+ + +
Sbjct: 344 NGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG-NIFANVNGLMAIQL 402
Query: 455 SHTHTRVAFNGIFNGLSSLEVLKMAGNSFQ 484
+ GIF+ L L L++ N ++
Sbjct: 403 QNNQLENLPLGIFDHLGKLCELRLYDNPWR 432
Score = 65.1 bits (157), Expect = 3e-10
Identities = 112/466 (24%), Positives = 185/466 (39%), Gaps = 92/466 (19%)
Query: 193 TDLRVLHQMPLLNLSLDLSL----NPMNFIQPGAFKEI-RLHKLTLRNNFDSLNVMKTCI 247
T + L++ P LN+S ++L N ++ I PGAF+ + L L+L NN L V+ +
Sbjct: 69 THITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANN--KLQVLPIGL 126
Query: 248 -QGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNC 306
QGL LE L + L + + NL + +L+Y D D
Sbjct: 127 FQGLDSLESLLL------SSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG 180
Query: 307 LT--NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGG 364
LT N+ SL ++ RV +QHL G L+L RLT
Sbjct: 181 LTKLNLGKNSLTHIS-PRV--------FQHL-------GNLQVLRLYE-NRLT------- 216
Query: 365 NAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQ 423
D+P F G +L+ L L N + +S F
Sbjct: 217 ------DIPMGTF------------------DGLVNLQELALQQNQIGLLSPGLFHNNHN 252
Query: 424 LEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSF 483
L+ L ++++ Q+ S+F+ L L L + + GIF + +L L + N
Sbjct: 253 LQRLYLSNNHISQLPP-SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHI 311
Query: 484 QENFLPD-IFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKC 542
LPD +F+ LR L L LS+ Q+ +SP AFN L+ L+ L++ N LD ++
Sbjct: 312 SS--LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRM 369
Query: 543 LNSLQVLDYSLNHI----------------MTSKKQELQHFP-------SSLAFLNLTQN 579
L +LQ + N + + + +L++ P L L L N
Sbjct: 370 LANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 429
Query: 580 DFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLNI 625
+ C + W+ + L C +P++ +G ++ +N+
Sbjct: 430 PWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINV 475
Score = 46.6 bits (109), Expect = 1e-04
Identities = 50/169 (29%), Positives = 73/169 (43%), Gaps = 18/169 (10%)
Query: 31 EVVPNITYQCMELNFYKIPDNLPFSTKNLDLS-FNP---LRHLGSYS----------FFS 76
++ P+I Q +LN + N S K L L F P LR L Y F +
Sbjct: 265 QLPPSIFMQLPQLNRLTLFGN---SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSN 321
Query: 77 FPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVET 136
+LQVL LSR +I I GA+ L+ L L L N +Q L F L++LQ +
Sbjct: 322 LRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN 381
Query: 137 NLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSN 185
L L ++ L + + +N +++ L F +L L L L N
Sbjct: 382 RLRQLPGNIFANVNGLMAIQLQNNQLENLPL-GIFDHLGKLCELRLYDN 429
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 83.6 bits (205), Expect = 7e-16
Identities = 111/450 (24%), Positives = 184/450 (40%), Gaps = 65/450 (14%)
Query: 39 QCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAY 98
+C +P LP++ +L + + L F + L L + + E+ I GA+
Sbjct: 38 ECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAF 97
Query: 99 QSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVA 158
++L L L L N +Q L +G F GL SL+ L+ L ++ LKEL +
Sbjct: 98 RNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLH 157
Query: 159 HNLIQSFKLPE-YFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNF 217
N ++ +P+ F +L L L+L N + I RV + L + L L N +
Sbjct: 158 GNHLE--YIPDGAFDHLVGLTKLNLGKNSLTHI---SPRVFQHLGNLQV-LRLYENRLTD 211
Query: 218 IQPGAFKE-IRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSA 276
I G F + L +L L+ N ++ L G F N NL++
Sbjct: 212 IPMGTFDGLVNLQELALQQN-----------------QIGLLSPGLFHNNHNLQR----- 249
Query: 277 LEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLE 336
L + ++ L +F L ++ +L FG E
Sbjct: 250 ------LYLSNNHISQLP------PSIFMQLPQLNRLTL--------------FGNSLKE 283
Query: 337 LVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDF 396
L FG P L+ L S+ N FS +L L+ L LSRN +SF S F
Sbjct: 284 LSLGIFGPMPNLRELWLYD-NHISSLPDNVFS--NLRQLQVLILSRNQISF---ISPGAF 337
Query: 397 -GTTSLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDI 454
G T L+ L L N + + N F L L+++ Q++ L+Q+ ++F ++ L+ + +
Sbjct: 338 NGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG-NIFANVNGLMAIQL 396
Query: 455 SHTHTRVAFNGIFNGLSSLEVLKMAGNSFQ 484
+ GIF+ L L L++ N ++
Sbjct: 397 QNNQLENLPLGIFDHLGKLCELRLYDNPWR 426
Score = 65.1 bits (157), Expect = 3e-10
Identities = 112/466 (24%), Positives = 185/466 (39%), Gaps = 92/466 (19%)
Query: 193 TDLRVLHQMPLLNLSLDLSL----NPMNFIQPGAFKEI-RLHKLTLRNNFDSLNVMKTCI 247
T + L++ P LN+S ++L N ++ I PGAF+ + L L+L NN L V+ +
Sbjct: 63 THITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANN--KLQVLPIGL 120
Query: 248 -QGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNC 306
QGL LE L + L + + NL + +L+Y D D
Sbjct: 121 FQGLDSLESLLL------SSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG 174
Query: 307 LT--NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGG 364
LT N+ SL ++ RV +QHL G L+L RLT
Sbjct: 175 LTKLNLGKNSLTHIS-PRV--------FQHL-------GNLQVLRLYE-NRLT------- 210
Query: 365 NAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQ 423
D+P F G +L+ L L N + +S F
Sbjct: 211 ------DIPMGTF------------------DGLVNLQELALQQNQIGLLSPGLFHNNHN 246
Query: 424 LEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSF 483
L+ L ++++ Q+ S+F+ L L L + + GIF + +L L + N
Sbjct: 247 LQRLYLSNNHISQLPP-SIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHI 305
Query: 484 QENFLPD-IFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKC 542
LPD +F+ LR L L LS+ Q+ +SP AFN L+ L+ L++ N LD ++
Sbjct: 306 SS--LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRM 363
Query: 543 LNSLQVLDYSLNHI----------------MTSKKQELQHFP-------SSLAFLNLTQN 579
L +LQ + N + + + +L++ P L L L N
Sbjct: 364 LANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN 423
Query: 580 DFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLNI 625
+ C + W+ + L C +P++ +G ++ +N+
Sbjct: 424 PWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINV 469
Score = 46.6 bits (109), Expect = 1e-04
Identities = 50/169 (29%), Positives = 73/169 (43%), Gaps = 18/169 (10%)
Query: 31 EVVPNITYQCMELNFYKIPDNLPFSTKNLDLS-FNP---LRHLGSYS----------FFS 76
++ P+I Q +LN + N S K L L F P LR L Y F +
Sbjct: 259 QLPPSIFMQLPQLNRLTLFGN---SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSN 315
Query: 77 FPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVET 136
+LQVL LSR +I I GA+ L+ L L L N +Q L F L++LQ +
Sbjct: 316 LRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN 375
Query: 137 NLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSN 185
L L ++ L + + +N +++ L F +L L L L N
Sbjct: 376 RLRQLPGNIFANVNGLMAIQLQNNQLENLPL-GIFDHLGKLCELRLYDN 423
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 82.8 bits (203), Expect = 1e-15
Identities = 130/505 (25%), Positives = 200/505 (39%), Gaps = 95/505 (18%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C +L ++P NL T LDLS N I +
Sbjct: 52 CSDLGLSELPSNLSVFTSYLDLSMN------------------------NISQLLPNPLP 87
Query: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
SL L L L GN + + GAF+GL SL+ L+ L + + +L++L+ L +
Sbjct: 88 SLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDA 147
Query: 160 NLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQ 219
N I S+ P FS L +L HL L N + I R L + ++ L+LN ++ I
Sbjct: 148 NHI-SYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ----AMTLALNKIHHIP 202
Query: 220 PGAFKEI-RLHKLTLRNN-FDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSAL 277
AF + L L L NN SL K C GL LE L N NL++F +A+
Sbjct: 203 DYAFGNLSSLVVLHLHNNRIHSLG--KKCFDGLHSLETLDL------NYNNLDEF-PTAI 253
Query: 278 EGLCNLTIEEFRLAYLDYYLDDIIDLFNCLTNVSSFSLVSVTI-ERVKDFSYNFGWQHLE 336
L N L L ++ ++I + V + SL+++ + F +QHL
Sbjct: 254 RTLSN-------LKELGFHSNNIRSIPE-KAFVGNPSLITIHFYDNPIQFVGRSAFQHLP 305
Query: 337 LVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDF 396
+ TL L ++T EF DL+
Sbjct: 306 -------ELRTLTLNGASQIT------------------EFPDLT--------------- 325
Query: 397 GTTSLKYLDLSFNGVITMSSNFLG-LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDIS 455
GT +L+ L L+ + ++ L L+ LD ++ L+ + FSV L+ +D+
Sbjct: 326 GTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQK---IDLR 382
Query: 456 HTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTA 515
H F L SL L +A N P+ F+ L +L LDLS L T
Sbjct: 383 HNEIYEIKVDTFQQLLSLRSLNLAWNKI-AIIHPNAFSTLPSLIKLDLSSNLLSSFPITG 441
Query: 516 FNSLSSLQVL-NMSHNNFFSLDTFP 539
+ L+ L++ N + + S + FP
Sbjct: 442 LHGLTHLKLTGNHALQSLISSENFP 466
Score = 70.9 bits (172), Expect = 5e-12
Identities = 104/418 (24%), Positives = 159/418 (38%), Gaps = 66/418 (15%)
Query: 166 KLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKE 225
+LP S T+ +LDLS N I + L L + L L+ N + +I GAF
Sbjct: 59 ELPSNLSVFTS--YLDLSMNNISQLLPNPLPSLRFLE----ELRLAGNALTYIPKGAFTG 112
Query: 226 IRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTI 285
+ K+ + N +V +Q L L+ RL + ++ S GL +L
Sbjct: 113 LYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRL------DANHISYVPPSCFSGLHSLR- 165
Query: 286 EEFRLAYLDYYLDDI-IDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQ 344
L D L +I + F L+ + + +L I + D+++
Sbjct: 166 ---HLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFG--------------- 207
Query: 345 FPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYL 404
+L SL L L N + G + G SL+ L
Sbjct: 208 --------------------------NLSSLVVLHLHNNRIHSLG--KKCFDGLHSLETL 239
Query: 405 DLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFN 464
DL++N + + L L+ L F +N++ + E F+ +LI + +
Sbjct: 240 DLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPE-KAFVGNPSLITIHFYDNPIQFVGR 298
Query: 465 GIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQV 524
F L L L + G S F PD+ T NL L L+ Q+ L T N L +LQV
Sbjct: 299 SAFQHLPELRTLTLNGASQITEF-PDL-TGTANLESLTLTGAQISSLPQTVCNQLPNLQV 356
Query: 525 LNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFA 582
L++S+N L +F LQ +D N I K Q SL LNL N A
Sbjct: 357 LDLSYNLLEDLPSF--SVCQKLQKIDLRHNEIYEIKVDTFQQL-LSLRSLNLAWNKIA 411
Score = 57.4 bits (137), Expect = 5e-08
Identities = 64/223 (28%), Positives = 104/223 (46%), Gaps = 22/223 (9%)
Query: 39 QCMELNFYKIPDNLPFSTKNL----DLSF--NPLRHLGSYSFFSFPELQVLDLSRCEIQT 92
+ ++LN+ + D P + + L +L F N +R + +F P L + IQ
Sbjct: 237 ETLDLNYNNL-DEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQF 295
Query: 93 IEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTL 152
+ A+Q L L TL L G Q +G ++L+ L ++SL L L
Sbjct: 296 VGRSAFQHLPELRTLTLNG-ASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNL 354
Query: 153 KELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNL-SLDLS 211
+ L++++NL++ LP FS L+ +DL N+I +++V LL+L SL+L+
Sbjct: 355 QVLDLSYNLLED--LPS-FSVCQKLQKIDLRHNEIY-----EIKVDTFQQLLSLRSLNLA 406
Query: 212 LNPMNFIQPGAFKEI-RLHKLTLRNNFDSLNVMKTCIQGLAGL 253
N + I P AF + L KL L +N + I GL GL
Sbjct: 407 WNKIAIIHPNAFSTLPSLIKLDLSSNL----LSSFPITGLHGL 445
Score = 50.4 bits (119), Expect = 7e-06
Identities = 47/121 (38%), Positives = 61/121 (50%), Gaps = 6/121 (4%)
Query: 59 LDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLA 118
LDLS+N L L S+S +LQ +DL EI I+ +Q L L +L L N I +
Sbjct: 357 LDLSYNLLEDLPSFSVCQ--KLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIH 414
Query: 119 LGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHN-LIQSFKLPEYFSNLTNL 177
AFS L SL KL + +NL L +FPI L L L + N +QS E F L +
Sbjct: 415 PNAFSTLPSLIKL-DLSSNL--LSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVI 471
Query: 178 E 178
E
Sbjct: 472 E 472
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 80.9 bits (198), Expect = 5e-15
Identities = 108/431 (25%), Positives = 178/431 (41%), Gaps = 60/431 (13%)
Query: 107 LILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFK 166
L L GN I + F+GL L+ L +E + ++E +K L+ L + N Q
Sbjct: 66 LELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRN--QLHM 123
Query: 167 LPE-YFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKE 225
LPE F N L LDLS N IQ+I R L NL LD N ++ I+ GAF+
Sbjct: 124 LPELLFQNNQALSRLDLSENAIQAIPRKAFR--GATDLKNLQLD--KNQISCIEEGAFRA 179
Query: 226 IR-LHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLT 284
+R L LTL NN + + + F + L F + C
Sbjct: 180 LRGLEVLTLNNN-----------------NITTIPVSSFNHMPKLRTFRLHSNHLFC--- 219
Query: 285 IEEFRLAYLDYYLDD--IIDLFNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKF 342
+ LA+L +L I LF + +S ++V + +FS + +
Sbjct: 220 --DCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCS--------GQGEA 269
Query: 343 GQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLK 402
G+ PT L S + G +D GL+ ++ T +
Sbjct: 270 GRVPTCTLSSGSCPAMCTCSNG------------IVDCRGKGLT----AIPANLPET-MT 312
Query: 403 YLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRV 461
+ L NG+ ++ F +L +D ++ + +++ F LR+L L +
Sbjct: 313 EIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAP-DAFQGLRSLNSLVLYGNKITD 371
Query: 462 AFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSS 521
G+F GL +L++L + N PD F +L+NL+ L L +++ L+ F SL +
Sbjct: 372 LPRGVFGGLYTLQLLLLNANKI-NCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRA 430
Query: 522 LQVLNMSHNNF 532
+Q L+++ N F
Sbjct: 431 IQTLHLAQNPF 441
Score = 71.6 bits (174), Expect = 3e-12
Identities = 45/148 (30%), Positives = 77/148 (52%), Gaps = 2/148 (1%)
Query: 39 QCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFS-FPELQVLDLSRCEIQTIEDGA 97
+C L KIP+ +P ST L L+ N + L + F L+ ++LS ++ IEDGA
Sbjct: 525 ECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGA 584
Query: 98 YQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNV 157
++ + +S L LT N ++S+ G F GL L+ L+ ++ + N L+ ++ L++
Sbjct: 585 FEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSL 644
Query: 158 AHNLIQSFKLPEYFSNLTNLEHLDLSSN 185
N I + P F L +L L+L +N
Sbjct: 645 YDNQITTVS-PGAFDTLQSLSTLNLLAN 671
Score = 71.2 bits (173), Expect = 4e-12
Identities = 116/474 (24%), Positives = 182/474 (38%), Gaps = 95/474 (20%)
Query: 28 PCVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSR 87
P + N C IP NLP + + L N ++ + +F + +L+ +DLS
Sbjct: 283 PAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSN 342
Query: 88 CEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIG 147
+I I A+Q L L++L+L GN I L G F GL +LQ L+
Sbjct: 343 NQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLL--------------- 387
Query: 148 HLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSI---YCTDLRVLHQMPLL 204
LN N I + P+ F +L NL L L NKIQS+ T LR +
Sbjct: 388 -------LNA--NKINCIR-PDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQ----- 432
Query: 205 NLSLDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFR 264
+L L+ NP FI K L N ++ + LA + ++ +FR
Sbjct: 433 --TLHLAQNP--FICDCNLK--WLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFR 486
Query: 265 NEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLD-----DIIDLFNC-----LTNVSSFS 314
C+ + F DY L+ D++ C + SS
Sbjct: 487 ----------------CSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLK 530
Query: 315 LVSVTIERVKDFSYNFGWQHLEL-VNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLP 373
L + ER+ + + E+ + G F KL LK++ ++NK SE++
Sbjct: 531 LTKIP-ERIPQSTAELRLNNNEISILEATGMFK--KLTHLKKINLSNNK----VSEIEDG 583
Query: 374 SLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHS 432
+ E G S+ L L+ N + ++ S F GL+ L L +++
Sbjct: 584 AFE--------------------GAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNN 623
Query: 433 NLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQEN 486
+ + S F LRN+ L + G F+ L SL L + N F N
Sbjct: 624 RISCIHNDS-FTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCN 676
Score = 62.4 bits (150), Expect = 2e-09
Identities = 47/197 (23%), Positives = 89/197 (45%), Gaps = 8/197 (4%)
Query: 425 EHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQ 484
E L+ +N+ ++ + + F L+ L L + G F+ + LE L++ N Q
Sbjct: 64 ERLELNGNNITRIHK-NDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRN--Q 120
Query: 485 ENFLPDI-FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCL 543
+ LP++ F + L+ LDLS+ ++ + AF + L+ L + N ++ ++ L
Sbjct: 121 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL 180
Query: 544 NSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVE 603
L+VL + N+I T H P F L N C C QW++ + + +
Sbjct: 181 RGLEVLTLNNNNITTIPVSSFNHMPKLRTF-RLHSNHLFCDCHLAWLSQWLRQRPTIGLF 239
Query: 604 VERMECATPSDKQGMPV 620
+C+ P+ +G+ V
Sbjct: 240 T---QCSGPASLRGLNV 253
Score = 53.1 bits (126), Expect = 1e-06
Identities = 44/168 (26%), Positives = 76/168 (45%), Gaps = 9/168 (5%)
Query: 455 SHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPT 514
S+ H R GI ++ L + GN F +P + + L +DLS ++ LS +
Sbjct: 748 SNKHLRALPKGIPKNVTELY---LDGNQF--TLVPGQLSTFKYLQLVDLSNNKISSLSNS 802
Query: 515 AFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFL 574
+F ++S L L +S+N + ++ L SL++L N I T ++ +SL+ L
Sbjct: 803 SFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADV-TSLSHL 861
Query: 575 NLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLS 622
+ N C C + W+K + E CA P D +G +L+
Sbjct: 862 AIGANPLYCDCHLRWLSSWVKTGYK---EPGIARCAGPQDMEGKLLLT 906
Score = 51.6 bits (122), Expect = 3e-06
Identities = 37/140 (26%), Positives = 71/140 (50%), Gaps = 5/140 (3%)
Query: 22 RPESWEPCVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHL-GSYSFFSFPEL 80
RP+ + C + + +C + +P +P + L L N + G S F + L
Sbjct: 731 RPQCPQECACL--DTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKY--L 786
Query: 81 QVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLAS 140
Q++DLS +I ++ + ++ ++S L+TLIL+ N +Q + AF GL SL+ L ++++
Sbjct: 787 QLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIST 846
Query: 141 LENFPIGHLKTLKELNVAHN 160
L+ + +L L + N
Sbjct: 847 LQEGIFADVTSLSHLAIGAN 866
Score = 47.4 bits (111), Expect = 6e-05
Identities = 32/122 (26%), Positives = 57/122 (46%), Gaps = 2/122 (1%)
Query: 411 VITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGL 470
++ + F L L+ ++ ++ + ++ + F ++ L ++ +G+F GL
Sbjct: 554 ILEATGMFKKLTHLKKINLSNNKVSEIED-GAFEGAASVSELHLTANQLESIRSGMFRGL 612
Query: 471 SSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN 530
L L + N D FT LRN+ L L Q+ +SP AF++L SL LN+ N
Sbjct: 613 DGLRTLMLRNNRIS-CIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLAN 671
Query: 531 NF 532
F
Sbjct: 672 PF 673
Score = 43.5 bits (101), Expect = 8e-04
Identities = 35/156 (22%), Positives = 65/156 (41%), Gaps = 5/156 (3%)
Query: 465 GIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQV 524
G+F L+ L+ + ++ N E F +++ L L+ QLE + F L L+
Sbjct: 559 GMFKKLTHLKKINLSNNKVSE-IEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRT 617
Query: 525 LNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACT 584
L + +N + + L ++++L N I T SL+ LNL N F C
Sbjct: 618 LMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTL-QSLSTLNLLANPFNCN 676
Query: 585 CEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPV 620
C+ W++ ++ + C P + +P+
Sbjct: 677 CQLAWLGGWLRKRK---IVTGNPRCQNPDFLRQIPL 709
Score = 41.2 bits (95), Expect = 0.004
Identities = 30/104 (28%), Positives = 44/104 (42%)
Query: 57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQS 116
+ L L+ N L L F + L LDLS IQ I A++ + L L L N I
Sbjct: 112 ERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISC 171
Query: 117 LALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHN 160
+ GAF L L+ L N+ ++ H+ L+ + N
Sbjct: 172 IEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSN 215
Score = 38.1 bits (87), Expect = 0.034
Identities = 58/233 (24%), Positives = 91/233 (39%), Gaps = 59/233 (25%)
Query: 57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTL--------- 107
+ L L N + + + SF +++L L +I T+ GA+ +L LSTL
Sbjct: 616 RTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNC 675
Query: 108 ---------------ILTGNP------------IQSLAL------------GAFSGLSSL 128
I+TGNP +Q +A G
Sbjct: 676 NCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCP 735
Query: 129 QKLVAVETNLAS----LENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSS 184
Q+ ++T + L P G K + EL + N Q +P S L+ +DLS+
Sbjct: 736 QECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGN--QFTLVPGQLSTFKYLQLVDLSN 793
Query: 185 NKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIR-LHKLTLRNN 236
NKI S+ + + Q+ +L LS N + I P AF+ +R L L+L N
Sbjct: 794 NKISSLSNSSFTNMSQL----TTLILSYNALQCIPPLAFQGLRSLRLLSLHGN 842
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 77.4 bits (189), Expect = 5e-14
Identities = 60/210 (28%), Positives = 96/210 (45%), Gaps = 8/210 (3%)
Query: 29 CVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRC 88
C V + +C ++P LP ++DL N LR LG +F + P L+ L L
Sbjct: 37 CSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHN 96
Query: 89 EIQTIEDGAYQSLSHLSTLILTGN-PIQSLALGAFSGLSSLQKLVAVETNLASLENFPIG 147
+ I GA++ L L+ L L N ++ L F+ LS L++L L S+ +
Sbjct: 97 NLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLA 156
Query: 148 HLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLS 207
L L+EL NL + ++P L NL H L +I+++ + L+ L ++ S
Sbjct: 157 ELPALRELAAFDNLFR--RVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRL----RS 210
Query: 208 LDLSLNPMNFIQPGAFKEIR-LHKLTLRNN 236
L L N + + GAF + L L L +N
Sbjct: 211 LSLQANRVRAVHAGAFGDCGVLEHLLLNDN 240
Score = 55.1 bits (131), Expect = 3e-07
Identities = 72/302 (23%), Positives = 121/302 (40%), Gaps = 37/302 (12%)
Query: 342 FGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDFGTTSL 401
FG P+L+ SL+ + G AF LP L L L+ NG + +++ + L
Sbjct: 82 FGTLPSLRRLSLRHNNLSFITPG-AFK--GLPRLAELRLAHNG-DLRYLHARTFAALSRL 137
Query: 402 KYLDLSFNGVITMSSNFL------------------------GLEQLEHLDFQHSNLKQM 437
+ LDL+ + ++ L GL L H + ++ +
Sbjct: 138 RRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAV 197
Query: 438 SEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLP-DIFTELR 496
+ S+ LR L L + R G F LE L + N E LP D F LR
Sbjct: 198 ASSSL-QGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAE--LPADAFRGLR 254
Query: 497 NLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHI 556
L L+L L++++ F L+ L++L + N+ ++ ++ L+ L L + N +
Sbjct: 255 RLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRL 314
Query: 557 MTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQ 616
Q L L L +N + C C L+W++D + V + CA+P
Sbjct: 315 TVLAWVAFQP-GFFLGRLFLFRNPWCCDCR----LEWLRDWMEGSGRVTDVPCASPGSVA 369
Query: 617 GM 618
G+
Sbjct: 370 GL 371
Score = 45.4 bits (106), Expect = 2e-04
Identities = 43/155 (27%), Positives = 69/155 (44%), Gaps = 7/155 (4%)
Query: 378 LDLSRNGLSFKGCCSQSDFGT-TSLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLK 435
+DL RNGL F G + FGT SL+ L L N + ++ F GL +L L H+
Sbjct: 67 IDLDRNGLRFLG---ERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDL 123
Query: 436 QMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTEL 495
+ F +L L LD++ + L +L L N F+ +P L
Sbjct: 124 RYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRR--VPGALRGL 181
Query: 496 RNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHN 530
NLT L + ++E ++ ++ L L+ L++ N
Sbjct: 182 ANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQAN 216
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/103 (29%), Positives = 48/103 (46%), Gaps = 1/103 (0%)
Query: 85 LSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENF 144
L R I+ + + Q L L +L L N ++++ GAF L+ L+ + LA L
Sbjct: 189 LERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPAD 248
Query: 145 PIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKI 187
L+ L+ LN+ N + +F++L LE L L N I
Sbjct: 249 AFRGLRRLRTLNLGGNALDRV-ARAWFADLAELELLYLDRNSI 290
Score = 42.0 bits (97), Expect = 0.002
Identities = 26/66 (39%), Positives = 36/66 (54%)
Query: 57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQS 116
+ L+L N L + F EL++L L R I +E+GA+Q+LS L L L GN +
Sbjct: 257 RTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTV 316
Query: 117 LALGAF 122
LA AF
Sbjct: 317 LAWVAF 322
Score = 35.8 bits (81), Expect = 0.17
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 1/106 (0%)
Query: 427 LDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQEN 486
+D + L+ + E F +L +L L + H + G F GL L L++A N
Sbjct: 67 IDLDRNGLRFLGE-RAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRY 125
Query: 487 FLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNF 532
F L L LDL+ C+L + L +L+ L N F
Sbjct: 126 LHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLF 171
Score = 34.3 bits (77), Expect = 0.49
Identities = 32/119 (26%), Positives = 49/119 (41%), Gaps = 1/119 (0%)
Query: 69 LGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSL 128
+ S S L+ L L ++ + GA+ L L+L N + L AF GL L
Sbjct: 197 VASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRL 256
Query: 129 QKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKI 187
+ L L + L L+ L + N I +F F NL+ L L L+ N++
Sbjct: 257 RTLNLGGNALDRVARAWFADLAELELLYLDRNSI-AFVEEGAFQNLSGLLALHLNGNRL 314
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 77.0 bits (188), Expect = 7e-14
Identities = 51/149 (34%), Positives = 73/149 (48%), Gaps = 3/149 (2%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C N ++PD +P T+ LDL N L+ + + +F P L LDL CE++ + +GA++
Sbjct: 48 CRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFR 107
Query: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
L L L L N ++ L A GL SL++L L L G L L LN+AH
Sbjct: 108 GLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAH 167
Query: 160 NLIQSFKLPEY-FSNLTNLEHLDLSSNKI 187
N + LP F L + L LS N +
Sbjct: 168 NAL--VYLPAMAFQGLLRVRWLRLSHNAL 194
Score = 61.2 bits (147), Expect = 4e-09
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 5/160 (3%)
Query: 422 EQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGN 481
E + LD Q NL ++ + F + +L +LD+ H + G F GL L +L +A N
Sbjct: 62 ELTQRLDLQ-GNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASN 120
Query: 482 SFQENFLP-DIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPY 540
+E LP + L +L L+L LE+L P F +L +L LN++HN L +
Sbjct: 121 HLRE--LPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAF 178
Query: 541 KCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQND 580
+ L ++ L S N + + L P +L L+L N+
Sbjct: 179 QGLLRVRWLRLSHNALSVLAPEALAGLP-ALRRLSLHHNE 217
Score = 50.1 bits (118), Expect = 9e-06
Identities = 43/156 (27%), Positives = 72/156 (46%), Gaps = 25/156 (16%)
Query: 404 LDLSFNGV-ITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVA 462
LDL N + + ++ F G+ L HLD +H ++ ++E F L L+ L+++ H R
Sbjct: 67 LDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAE-GAFRGLGRLLLLNLASNHLREL 125
Query: 463 FNGIFNGLSSLEVLKMAGNSFQEN----------------------FLPDI-FTELRNLT 499
+GL SL L++ GN+ +E +LP + F L +
Sbjct: 126 PQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVR 185
Query: 500 FLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSL 535
+L LS L L+P A L +L+ L++ HN +L
Sbjct: 186 WLRLSHNALSVLAPEALAGLPALRRLSLHHNELQAL 221
Score = 50.1 bits (118), Expect = 9e-06
Identities = 52/179 (29%), Positives = 78/179 (43%), Gaps = 6/179 (3%)
Query: 59 LDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLA 118
L+L+ N LR L + L+ L+L ++ + G + +L L+TL L N + L
Sbjct: 115 LNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLP 174
Query: 119 LGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLE 178
AF GL ++ L L+ L + L L+ L++ HN +Q+ P S L
Sbjct: 175 AMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGP-VLSQARGLA 233
Query: 179 HLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEI-RLHKLTLRNN 236
L+L N + Y + L L L LD + + P AF RLH L LR N
Sbjct: 234 RLELGHNPL--TYAGEEDGLALPGLRELLLD--GGALQALGPRAFAHCPRLHTLDLRGN 288
Score = 50.1 bits (118), Expect = 9e-06
Identities = 54/219 (24%), Positives = 79/219 (36%), Gaps = 23/219 (10%)
Query: 29 CVEVVPNITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRC 88
CV V + C +P P T+ LDL N + +F L L L C
Sbjct: 400 CVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHC 459
Query: 89 EIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGH 148
I +E GA L L L L+ N + L+ A G L L + +
Sbjct: 460 GIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRA 519
Query: 149 LKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIY------CTDLRVLH--- 199
L +L L++ N + P L + LS N+I + +L LH
Sbjct: 520 LPSLFSLHLQDNAVDRL-APGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDR 578
Query: 200 ------------QMPLLNLSLDLSLNPMNFIQPGAFKEI 226
+P L L L LS NP+ ++ GAF+ +
Sbjct: 579 NQLREVPTGALEGLPAL-LELQLSGNPLRALRDGAFQPV 616
Score = 44.7 bits (104), Expect = 4e-04
Identities = 70/293 (23%), Positives = 108/293 (36%), Gaps = 41/293 (13%)
Query: 335 LELVNCKFGQFPTLKLKSLKRLTF---TSNK--GGNAFSEVDLPSLEFLDLSRNG-LSFK 388
L L +C + L L RL + + N+ G +A + P L +L L RN L
Sbjct: 454 LHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVP 513
Query: 389 GCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRN 448
G ++ SL L L N V ++ LG + + N R
Sbjct: 514 GAALRA---LPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARE 570
Query: 449 LIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQL 508
L L + R G GL +L L+++GN + R+L L L+ L
Sbjct: 571 LEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGL 630
Query: 509 EQLSPTAFNSLS-SLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHF 567
EQ+ P AF+ L LQ L++ N +L P L+ L+++D
Sbjct: 631 EQICPGAFSGLGPGLQSLHLQKNQLRALPALP--SLSQLELID----------------- 671
Query: 568 PSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPV 620
L+ N F C C+ +W+ + CATP + +G V
Sbjct: 672 --------LSSNPFHCDCQLLPLHRWLTGLNLRV----GATCATPPNARGQRV 712
Score = 43.5 bits (101), Expect = 8e-04
Identities = 46/178 (25%), Positives = 79/178 (44%), Gaps = 9/178 (5%)
Query: 55 STKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPI 114
S + L+L N L L +F + L L+L+ + + A+Q L + L L+ N +
Sbjct: 135 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNAL 194
Query: 115 QSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNL 174
LA A +GL +L++L L +L + + L L + HN + ++ E L
Sbjct: 195 SVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPL-TYAGEEDGLAL 253
Query: 175 TNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQ----PGAFKEIRL 228
L L L +Q++ R P L+ +LDL N ++ + PG + +RL
Sbjct: 254 PGLRELLLDGGALQAL---GPRAFAHCPRLH-TLDLRGNQLDTLPPLQGPGQLRRLRL 307
Score = 40.8 bits (94), Expect = 0.005
Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 4/106 (3%)
Query: 57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSH-LSTLILTGNPIQ 115
+ L L N LR + + + P L L LS ++ + DGA+Q + L L L + ++
Sbjct: 572 EKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLE 631
Query: 116 SLALGAFSGLS-SLQKLVAVETNLASLENFPIGHLKTLKELNVAHN 160
+ GAFSGL LQ L + L +L P L L+ ++++ N
Sbjct: 632 QICPGAFSGLGPGLQSLHLQKNQLRALPALP--SLSQLELIDLSSN 675
Score = 37.4 bits (85), Expect = 0.058
Identities = 35/130 (26%), Positives = 54/130 (41%), Gaps = 3/130 (2%)
Query: 492 FTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDY 551
F + +LT LDL C++E ++ AF L L +LN++ N+ L L SL+ L+
Sbjct: 82 FQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLEL 141
Query: 552 SLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERMECAT 611
N + + +LA LNL N A Q + R L + +
Sbjct: 142 EGNALEELRPGTFGAL-GALATLNLAHN--ALVYLPAMAFQGLLRVRWLRLSHNALSVLA 198
Query: 612 PSDKQGMPVL 621
P G+P L
Sbjct: 199 PEALAGLPAL 208
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 76.6 bits (187), Expect = 9e-14
Identities = 76/262 (29%), Positives = 107/262 (40%), Gaps = 11/262 (4%)
Query: 365 NAFSEVDL---PSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGL 421
N FS V L PS + L L N + FG+ L S N F L
Sbjct: 49 NNFSSVPLSLPPSTQRLFLQNNLIR---TLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHL 105
Query: 422 EQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGN 481
+ LE LD + + E F L L L + IF GL SL+ L + N
Sbjct: 106 QALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQEN 165
Query: 482 SFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYK 541
S + D+F +L NL+ L L +L L+ F L SL L + N + ++
Sbjct: 166 SLL-HLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFR 224
Query: 542 CLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLL 601
L+ L +L Y N+ + S E SL FL L N +AC C + W + R
Sbjct: 225 GLSRLTIL-YLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRAR--- 280
Query: 602 VEVERMECATPSDKQGMPVLSL 623
V + CATP ++QG + +L
Sbjct: 281 VSSSDVTCATPPERQGRDLRAL 302
Score = 53.9 bits (128), Expect = 6e-07
Identities = 53/193 (27%), Positives = 81/193 (41%), Gaps = 24/193 (12%)
Query: 37 TYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFS-------------------- 76
T C NF +P +LP ST+ L L N +R L +F S
Sbjct: 43 TVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTF 102
Query: 77 --FPELQVLDLS-RCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVA 133
L+ LDL ++++E +Q L L +L L + SL F GL SLQ L
Sbjct: 103 RHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYL 162
Query: 134 VETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCT 193
E +L L++ L L L + N ++ F L +L+ L L N++Q ++
Sbjct: 163 QENSLLHLQDDLFADLANLSHLFLHGNRLR-LLTEHVFRGLGSLDRLLLHGNRLQGVHRA 221
Query: 194 DLRVLHQMPLLNL 206
R L ++ +L L
Sbjct: 222 AFRGLSRLTILYL 234
Score = 44.7 bits (104), Expect = 4e-04
Identities = 39/146 (26%), Positives = 63/146 (43%), Gaps = 6/146 (4%)
Query: 18 LSCVRPESWEPCVEVVPNITYQCMELNFYKIPDNL---PFSTKNLDLSFNPLRHLGSYSF 74
L + P++++ + Y+C +P N+ S + L L N L HL F
Sbjct: 119 LRSLEPDTFQGLERLQSLHLYRCQ---LSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLF 175
Query: 75 FSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAV 134
L L L ++ + + ++ L L L+L GN +Q + AF GLS L L
Sbjct: 176 ADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLF 235
Query: 135 ETNLASLENFPIGHLKTLKELNVAHN 160
+LASL + L +L+ L + N
Sbjct: 236 NNSLASLPGEALADLPSLEFLRLNAN 261
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 76.3 bits (186), Expect = 1e-13
Identities = 72/282 (25%), Positives = 122/282 (43%), Gaps = 59/282 (20%)
Query: 371 DLPSLEFLDLSRNGLSFKGCCSQSDFGTTSLKYLDLSFNGVITMSSN-----------FL 419
DL S+++L+L RN L+ G S + G +L+ LDLS N ++ +S + +L
Sbjct: 154 DLVSVQYLNLQRNRLTVLG--SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYL 211
Query: 420 G--------------LEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNG 465
G L+ L L H+ ++ + F+ F L NL YL + ++ R
Sbjct: 212 GSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFA-FKGLANLEYLLLKNSRIRNVTRD 270
Query: 466 IFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSL-SSLQV 524
F+G+++L+ L ++ N EN D F+ L+NL +L L + ++ + F ++ +SL++
Sbjct: 271 GFSGINNLKHLILSHNDL-ENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKI 329
Query: 525 LNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACT 584
LN+S NN +L K L SSL L N + C
Sbjct: 330 LNLSFNNLTALHPRVLKPL-------------------------SSLIHLQANSNPWECN 364
Query: 585 CEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPVLSLNIT 626
C+ W+ L + C P +G + +NIT
Sbjct: 365 CKLLGLRDWLASSAITL----NIYCQNPPSMRGRALRYINIT 402
Score = 67.4 bits (163), Expect = 5e-11
Identities = 74/275 (26%), Positives = 108/275 (39%), Gaps = 24/275 (8%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C L IP N P ST L L+ N + ++ L L L I + A+
Sbjct: 46 CRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFV 105
Query: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
L HL L L N I+ L G F GL +L+ L ++ + L +++ LN+
Sbjct: 106 QLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQR 165
Query: 160 NLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLS------------ 207
N + F + L LDLS+N I I + + L + L L
Sbjct: 166 NRLTVLG-SGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAF 224
Query: 208 --------LDLSLNPMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLV 259
L LS NP+ IQP AFK + + L N NV + G+ L+ L+
Sbjct: 225 EVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLK--HLI 282
Query: 260 LGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLD 294
L E NL S L+ L L ++ R+ +D
Sbjct: 283 LSHNDLE-NLNSDTFSLLKNLIYLKLDRNRIISID 316
Score = 65.5 bits (158), Expect = 2e-10
Identities = 50/174 (28%), Positives = 87/174 (50%), Gaps = 3/174 (1%)
Query: 55 STKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPI 114
S + L+L N L LGS +F L++LDLS I I + +Q L +L+ L L N +
Sbjct: 157 SVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNL 216
Query: 115 QSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNL 174
+ AF L SL++L + +++ F L L+ L + ++ I++ + FS +
Sbjct: 217 TKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNV-TRDGFSGI 275
Query: 175 TNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLD--LSLNPMNFIQPGAFKEI 226
NL+HL LS N ++++ +L + L L + +S++ F GA +I
Sbjct: 276 NNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKI 329
Score = 52.4 bits (124), Expect = 2e-06
Identities = 55/209 (26%), Positives = 95/209 (45%), Gaps = 7/209 (3%)
Query: 410 GVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNG 469
G+ ++ NF E L +N+ ++E S L +L+ L + +++ + F
Sbjct: 50 GLSSIPKNFP--ESTVFLYLTGNNISYINE-SELTGLHSLVALYLDNSNILYVYPKAFVQ 106
Query: 470 LSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSH 529
L L L + N+F + P IF L NL L L Q+ + FN L S+Q LN+
Sbjct: 107 LRHLYFLFL-NNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQR 165
Query: 530 NNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLTQNDFACTCEHQS 589
N L + + + +L++LD S N+I+ + QH +LA L L N+ T +
Sbjct: 166 NRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHL-ENLACLYLGSNNL--TKVPSN 222
Query: 590 FLQWIKDQRQLLVEVERMECATPSDKQGM 618
+ +K R+L + +E P +G+
Sbjct: 223 AFEVLKSLRRLSLSHNPIEAIQPFAFKGL 251
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 75.1 bits (183), Expect = 3e-13
Identities = 68/223 (30%), Positives = 108/223 (48%), Gaps = 8/223 (3%)
Query: 400 SLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 458
+L+ LDLS+N + T+ S F GL +L L + ++LK + VF RNL +LD+ +
Sbjct: 134 NLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVP-IRVFQDCRNLDFLDLGYNR 192
Query: 459 TRVAFNGIFNGLSSLEVLKMAGNSFQE-NFLPDIFTELRNLTFLDLSQCQLEQLSPTAFN 517
R F GL L+ L + N F + NF F L NL + L ++ +S
Sbjct: 193 LRSLSRNAFAGLLKLKELHLEHNQFSKINFAH--FPRLFNLRSIYLQWNRIRSISQGLTW 250
Query: 518 SLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLT 577
+ SSL L++S N+ ++ +KCL +LQ L+ N +T+ QE + SL + L+
Sbjct: 251 TWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNK-LTNISQETVNAWISLISITLS 309
Query: 578 QNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPV 620
N + C+ W+K+ + + M CA P QG V
Sbjct: 310 GNMWECSRSICPLFYWLKNFKG--NKESTMICAGPKHIQGEKV 350
Score = 70.1 bits (170), Expect = 8e-12
Identities = 59/184 (32%), Positives = 87/184 (47%), Gaps = 12/184 (6%)
Query: 57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQS 116
K L LS N + +L + +F P L+ LDLS ++QT++ ++ L L L L N +++
Sbjct: 112 KELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKT 171
Query: 117 LALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTN 176
+ + F +L L L SL L LKEL++ HN +F L N
Sbjct: 172 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINF-AHFPRLFN 230
Query: 177 LEHLDLSSNKIQSI---YCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEI-RLHKLT 232
L + L N+I+SI LH +LDLS N + I+PG FK + L KL
Sbjct: 231 LRSIYLQWNRIRSISQGLTWTWSSLH-------NLDLSGNDIQGIEPGTFKCLPNLQKLN 283
Query: 233 LRNN 236
L +N
Sbjct: 284 LDSN 287
Score = 63.9 bits (154), Expect = 6e-10
Identities = 60/201 (29%), Positives = 89/201 (44%), Gaps = 26/201 (12%)
Query: 404 LDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLKQMSEFS--------------------- 441
L L FN + + SN F GL QL L H+ + + E +
Sbjct: 66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
Query: 442 --VFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLT 499
F + NL LD+S+ + + F GL L +L + NS + + +F + RNL
Sbjct: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIR-VFQDCRNLD 184
Query: 500 FLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTS 559
FLDL +L LS AF L L+ L++ HN F ++ + L +L+ + N I S
Sbjct: 185 FLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRI-RS 243
Query: 560 KKQELQHFPSSLAFLNLTQND 580
Q L SSL L+L+ ND
Sbjct: 244 ISQGLTWTWSSLHNLDLSGND 264
Score = 62.8 bits (151), Expect = 1e-09
Identities = 64/261 (24%), Positives = 117/261 (44%), Gaps = 25/261 (9%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C F IP+N+ ++ L L FN ++ L S F +L L L I ++++ A+Q
Sbjct: 47 CESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQ 106
Query: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
+ L LIL+ N I L F + +L+ L L +L++ L+ L L++
Sbjct: 107 GIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRS 166
Query: 160 NLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQ 219
N +++ + F + NL+ LDL N+++S+ L ++ L+L + + +NF
Sbjct: 167 NSLKTVPI-RVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHN-QFSKINFAH 224
Query: 220 -PGAFKEIRLHKLTLRNNFDSLNVMKTCIQG------------LAGLEVHRLVLGEFRNE 266
P F LR+ + N +++ QG L+G ++ + G F+
Sbjct: 225 FPRLF--------NLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCL 276
Query: 267 GNLEK--FDKSALEGLCNLTI 285
NL+K D + L + T+
Sbjct: 277 PNLQKLNLDSNKLTNISQETV 297
Score = 36.6 bits (83), Expect = 0.100
Identities = 28/105 (26%), Positives = 45/105 (42%)
Query: 57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQS 116
K L L N + F L+ + L I++I G + S L L L+GN IQ
Sbjct: 208 KELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQG 267
Query: 117 LALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNL 161
+ G F L +LQKL L ++ + +L + ++ N+
Sbjct: 268 IEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNM 312
Score = 30.4 bits (67), Expect = 7.1
Identities = 18/58 (31%), Positives = 29/58 (50%)
Query: 55 STKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGN 112
S NLDLS N ++ + +F P LQ L+L ++ I + L ++ L+GN
Sbjct: 254 SLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 75.1 bits (183), Expect = 3e-13
Identities = 68/223 (30%), Positives = 108/223 (48%), Gaps = 8/223 (3%)
Query: 400 SLKYLDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTH 458
+L+ LDLS+N + T+ S F GL +L L + ++LK + VF RNL +LD+ +
Sbjct: 134 NLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVP-IRVFQDCRNLDFLDLGYNR 192
Query: 459 TRVAFNGIFNGLSSLEVLKMAGNSFQE-NFLPDIFTELRNLTFLDLSQCQLEQLSPTAFN 517
R F GL L+ L + N F + NF F L NL + L ++ +S
Sbjct: 193 LRSLSRNAFAGLLKLKELHLEHNQFSKINFAH--FPRLFNLRSIYLQWNRIRSISQGLTW 250
Query: 518 SLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQHFPSSLAFLNLT 577
+ SSL L++S N+ ++ +KCL +LQ L+ N +T+ QE + SL + L+
Sbjct: 251 TWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNK-LTNISQETVNAWISLISITLS 309
Query: 578 QNDFACTCEHQSFLQWIKDQRQLLVEVERMECATPSDKQGMPV 620
N + C+ W+K+ + + M CA P QG V
Sbjct: 310 GNMWECSRSICPLFYWLKNFKG--NKESTMICAGPKHIQGEKV 350
Score = 70.1 bits (170), Expect = 8e-12
Identities = 59/184 (32%), Positives = 87/184 (47%), Gaps = 12/184 (6%)
Query: 57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQS 116
K L LS N + +L + +F P L+ LDLS ++QT++ ++ L L L L N +++
Sbjct: 112 KELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKT 171
Query: 117 LALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTN 176
+ + F +L L L SL L LKEL++ HN +F L N
Sbjct: 172 VPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINF-AHFPRLFN 230
Query: 177 LEHLDLSSNKIQSI---YCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEI-RLHKLT 232
L + L N+I+SI LH +LDLS N + I+PG FK + L KL
Sbjct: 231 LRSIYLQWNRIRSISQGLTWTWSSLH-------NLDLSGNDIQGIEPGTFKCLPNLQKLN 283
Query: 233 LRNN 236
L +N
Sbjct: 284 LDSN 287
Score = 63.9 bits (154), Expect = 6e-10
Identities = 60/201 (29%), Positives = 89/201 (44%), Gaps = 26/201 (12%)
Query: 404 LDLSFNGVITMSSN-FLGLEQLEHLDFQHSNLKQMSEFS--------------------- 441
L L FN + + SN F GL QL L H+ + + E +
Sbjct: 66 LSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLH 125
Query: 442 --VFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLT 499
F + NL LD+S+ + + F GL L +L + NS + + +F + RNL
Sbjct: 126 NKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIR-VFQDCRNLD 184
Query: 500 FLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTS 559
FLDL +L LS AF L L+ L++ HN F ++ + L +L+ + N I S
Sbjct: 185 FLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRI-RS 243
Query: 560 KKQELQHFPSSLAFLNLTQND 580
Q L SSL L+L+ ND
Sbjct: 244 ISQGLTWTWSSLHNLDLSGND 264
Score = 62.8 bits (151), Expect = 1e-09
Identities = 64/261 (24%), Positives = 117/261 (44%), Gaps = 25/261 (9%)
Query: 40 CMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQ 99
C F IP+N+ ++ L L FN ++ L S F +L L L I ++++ A+Q
Sbjct: 47 CESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQ 106
Query: 100 SLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAH 159
+ L LIL+ N I L F + +L+ L L +L++ L+ L L++
Sbjct: 107 GIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRS 166
Query: 160 NLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQ 219
N +++ + F + NL+ LDL N+++S+ L ++ L+L + + +NF
Sbjct: 167 NSLKTVPI-RVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHN-QFSKINFAH 224
Query: 220 -PGAFKEIRLHKLTLRNNFDSLNVMKTCIQG------------LAGLEVHRLVLGEFRNE 266
P F LR+ + N +++ QG L+G ++ + G F+
Sbjct: 225 FPRLF--------NLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCL 276
Query: 267 GNLEK--FDKSALEGLCNLTI 285
NL+K D + L + T+
Sbjct: 277 PNLQKLNLDSNKLTNISQETV 297
Score = 36.6 bits (83), Expect = 0.100
Identities = 28/105 (26%), Positives = 45/105 (42%)
Query: 57 KNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQS 116
K L L N + F L+ + L I++I G + S L L L+GN IQ
Sbjct: 208 KELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQG 267
Query: 117 LALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNL 161
+ G F L +LQKL L ++ + +L + ++ N+
Sbjct: 268 IEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNM 312
Score = 30.4 bits (67), Expect = 7.1
Identities = 18/58 (31%), Positives = 29/58 (50%)
Query: 55 STKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGN 112
S NLDLS N ++ + +F P LQ L+L ++ I + L ++ L+GN
Sbjct: 254 SLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGN 311
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,448,180
Number of Sequences: 37866
Number of extensions: 1242770
Number of successful extensions: 5455
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 169
Number of HSP's successfully gapped in prelim test: 117
Number of HSP's that attempted gapping in prelim test: 2956
Number of HSP's gapped (non-prelim): 1379
length of query: 839
length of database: 18,247,518
effective HSP length: 111
effective length of query: 728
effective length of database: 14,044,392
effective search space: 10224317376
effective search space used: 10224317376
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.