Guide to the Human Genome
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Search of human proteins with 19923485

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19923485 cisplatin resistance-associated overexpressed
protein [Homo sapiens]
         (432 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|52426743 cisplatin resistance-associated overexpressed protei...   849   0.0  
gi|19923485 cisplatin resistance-associated overexpressed protei...   849   0.0  
gi|116812577 LUC7-like 2 [Homo sapiens]                               241   9e-64
gi|41393554 LUC7-like isoform b [Homo sapiens]                        212   5e-55
gi|8922297 LUC7-like isoform a [Homo sapiens]                         204   1e-52
gi|55741709 RNA binding motif protein 25 [Homo sapiens]               135   9e-32
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...   125   1e-28
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]           121   1e-27
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]           118   1e-26
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]       118   1e-26
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]           117   2e-26
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...   112   7e-25
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...   112   7e-25
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...   110   3e-24
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]           109   6e-24
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi...   108   1e-23
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti...   107   2e-23
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s...   107   2e-23
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                 104   1e-22
gi|38146113 arginine/serine-rich coiled-coil 2 isoform b [Homo s...   103   3e-22
gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]           102   5e-22
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]    102   7e-22
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]    101   1e-21
gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]           97   3e-20
gi|29568103 U1 small nuclear ribonucleoprotein 70 kDa [Homo sapi...    96   5e-20
gi|42741682 zinc finger protein 265 isoform 2 [Homo sapiens]           95   1e-19
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]          94   2e-19
gi|148746195 trichohyalin [Homo sapiens]                               92   7e-19
gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]           91   2e-18
gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]           91   2e-18

>gi|52426743 cisplatin resistance-associated overexpressed protein
           [Homo sapiens]
          Length = 432

 Score =  849 bits (2194), Expect = 0.0
 Identities = 432/432 (100%), Positives = 432/432 (100%)

Query: 1   MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEK 60
           MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEK
Sbjct: 1   MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEK 60

Query: 61  IHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAG 120
           IHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAG
Sbjct: 61  IHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAG 120

Query: 121 PTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIE 180
           PTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIE
Sbjct: 121 PTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIE 180

Query: 181 SFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE 240
           SFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE
Sbjct: 181 SFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE 240

Query: 241 PDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHS 300
           PDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHS
Sbjct: 241 PDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHS 300

Query: 301 SRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS 360
           SRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS
Sbjct: 301 SRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS 360

Query: 361 YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTS 420
           YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTS
Sbjct: 361 YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTS 420

Query: 421 EDIKSEGDTQSN 432
           EDIKSEGDTQSN
Sbjct: 421 EDIKSEGDTQSN 432


>gi|19923485 cisplatin resistance-associated overexpressed protein
           [Homo sapiens]
          Length = 432

 Score =  849 bits (2194), Expect = 0.0
 Identities = 432/432 (100%), Positives = 432/432 (100%)

Query: 1   MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEK 60
           MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEK
Sbjct: 1   MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEK 60

Query: 61  IHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAG 120
           IHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAG
Sbjct: 61  IHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAG 120

Query: 121 PTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIE 180
           PTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIE
Sbjct: 121 PTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIE 180

Query: 181 SFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE 240
           SFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE
Sbjct: 181 SFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE 240

Query: 241 PDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHS 300
           PDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHS
Sbjct: 241 PDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHS 300

Query: 301 SRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS 360
           SRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS
Sbjct: 301 SRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS 360

Query: 361 YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTS 420
           YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTS
Sbjct: 361 YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTS 420

Query: 421 EDIKSEGDTQSN 432
           EDIKSEGDTQSN
Sbjct: 421 EDIKSEGDTQSN 432


>gi|116812577 LUC7-like 2 [Homo sapiens]
          Length = 392

 Score =  241 bits (615), Expect = 9e-64
 Identities = 144/391 (36%), Positives = 229/391 (58%), Gaps = 23/391 (5%)

Query: 7   LLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENL 66
           +LD+LMG  R+   D  R  +++  + VCK +L   CP ++ + TR DLG C K+HD  L
Sbjct: 10  MLDQLMGTSRD--GDTTRQRIKFSDDRVCKSHLLNCCPHDVLSGTRMDLGECLKVHDLAL 67

Query: 67  RKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNE 126
           R  YE +S+     +E D + +LQS +A+ +RR      RLA +Q + S+  A       
Sbjct: 68  RADYEIASKEQDFFFELDAMDHLQSFIADCDRRTEVAKKRLAETQEEISAEVAAKA---- 123

Query: 127 EKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLK-EERELLRSTTSTIESFAAQ 185
           E++  L ++I  LL ++E+LG+EG VEE+Q +M  VE+ + ++RE      +++ + + Q
Sbjct: 124 ERVHELNEEIGKLLAKVEQLGAEGNVEESQKVMDEVEKARAKKREAEEVYRNSMPASSFQ 183

Query: 186 EKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDE 245
           ++++ VCEVC A+L + D   R+ DH  GK H+G+ +I+  +EELK  + ++ E+ +++ 
Sbjct: 184 QQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIEIREKLEELKRVVAEKQEKRNQER 243

Query: 246 RLKKEKQEREEREK-EREREREERERKRRREEEEREKERARDRERRKRSRSRS-----RH 299
             ++E++EREEREK  R R   +  ++ R  E  R + R+  RER++R+RS+S     RH
Sbjct: 244 LKRREEREREEREKLRRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKRHRH 303

Query: 300 SSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRK 359
            SR+S R  SRSR H+RSR   R RSR R +RRS        K R R +D   S  RDR 
Sbjct: 304 RSRSSSR--SRSRSHQRSRHSSRDRSRERSKRRS-------SKERFRDQD-LASCDRDRS 353

Query: 360 SYKHRSKSRDREQDRKSKEKEKRGSDDKKSS 390
           S     + RDR+  ++S E     S+D++SS
Sbjct: 354 SRDRSPRDRDRKDKKRSYESANGRSEDRRSS 384


>gi|41393554 LUC7-like isoform b [Homo sapiens]
          Length = 371

 Score =  212 bits (540), Expect = 5e-55
 Identities = 130/375 (34%), Positives = 209/375 (55%), Gaps = 18/375 (4%)

Query: 7   LLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENL 66
           LLD+LMG  R+   DE R  V++  + VCK +L   CP ++   TR DLG C KIHD  L
Sbjct: 10  LLDQLMGTARD--GDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLAL 67

Query: 67  RKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNE 126
           R  YE +S+   + +E D + +L+S +AE +RR      RLA +Q + S+  +       
Sbjct: 68  RADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKA---- 123

Query: 127 EKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLK-EERELLRSTTSTIESFAAQ 185
           EK+  L ++I  LL + E+LG+EG V+E+Q ++  VE+++ +++E      +++ + + Q
Sbjct: 124 EKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQ 183

Query: 186 EKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDE 245
           ++++ VCEVC A+L + D   R+ DH  GK H+G+ +I+  +++L++ + ++ E+ ++D 
Sbjct: 184 QQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDR 243

Query: 246 RLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSD 305
             ++E++EREER   R   R    R+ R  +  R + R+  RERRK SRSRSR   R   
Sbjct: 244 LRRREEREREERLSRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKLSRSRSRDRHR--- 300

Query: 306 RRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRS 365
           R  SRSR H R     RR SR R  +   S +R+ R+    S    R     R       
Sbjct: 301 RHRSRSRSHSRG---HRRASRDRSAKYKFSRERASREESWESGRSERGPPDWR-----LE 352

Query: 366 KSRDREQDRKSKEKE 380
            S  +   R+S+EKE
Sbjct: 353 SSNGKMASRRSEEKE 367



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 57/227 (25%), Positives = 102/227 (44%), Gaps = 21/227 (9%)

Query: 221 AKIKATVEELKE------KLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRR 273
           A++ A  E++ E      KL  + E+   +  + + ++   E EK R +++E E E +  
Sbjct: 117 AEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNS 176

Query: 274 REEEEREKERARDRERRKRSRSRSRHSSRTSDR----------RCSRSRDHKRSRSRERR 323
                 ++++ R  E          +  R +D           +     D  R    E++
Sbjct: 177 MPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQ 236

Query: 324 RSRSRDR-RRSRSHDRSERKHR---SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEK 379
             R++DR RR    +R ER  R   SR+RDRRRS+SRDR+  + RS SR+R +  +S+ +
Sbjct: 237 EKRNQDRLRRREEREREERLSRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKLSRSRSR 296

Query: 380 EKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSE 426
           ++      +S   S    + S D + + K S  +     + E  +SE
Sbjct: 297 DRHRRHRSRSRSHSRGHRRASRDRSAKYKFSRERASREESWESGRSE 343


>gi|8922297 LUC7-like isoform a [Homo sapiens]
          Length = 325

 Score =  204 bits (519), Expect = 1e-52
 Identities = 118/326 (36%), Positives = 191/326 (58%), Gaps = 13/326 (3%)

Query: 7   LLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENL 66
           LLD+LMG  R+   DE R  V++  + VCK +L   CP ++   TR DLG C KIHD  L
Sbjct: 10  LLDQLMGTARD--GDETRQRVKFTDDRVCKSHLLDCCPHDILAGTRMDLGECTKIHDLAL 67

Query: 67  RKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNE 126
           R  YE +S+   + +E D + +L+S +AE +RR      RLA +Q + S+  +       
Sbjct: 68  RADYEIASKERDLFFELDAMDHLESFIAECDRRTELAKKRLAETQEEISAEVSAKA---- 123

Query: 127 EKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLK-EERELLRSTTSTIESFAAQ 185
           EK+  L ++I  LL + E+LG+EG V+E+Q ++  VE+++ +++E      +++ + + Q
Sbjct: 124 EKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNSMPASSFQ 183

Query: 186 EKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDE 245
           ++++ VCEVC A+L + D   R+ DH  GK H+G+ +I+  +++L++ + ++ E+ ++D 
Sbjct: 184 QQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQEKRNQDR 243

Query: 246 RLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSD 305
             ++E++EREER   R   R    R+ R  +  R + R+  RERRK SRSRSR   R   
Sbjct: 244 LRRREEREREERLSRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKLSRSRSRDRHR--- 300

Query: 306 RRCSRSRDHKRSRSRERRRSRSRDRR 331
           R  SRSR H R     RR SR R  +
Sbjct: 301 RHRSRSRSHSRG---HRRASRDRSAK 323



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 53/209 (25%), Positives = 95/209 (45%), Gaps = 21/209 (10%)

Query: 221 AKIKATVEELKE------KLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRR 273
           A++ A  E++ E      KL  + E+   +  + + ++   E EK R +++E E E +  
Sbjct: 117 AEVSAKAEKVHELNEEIGKLLAKAEQLGAEGNVDESQKILMEVEKVRAKKKEAEEEYRNS 176

Query: 274 REEEEREKERARDRERRKRSRSRSRHSSRTSDR----------RCSRSRDHKRSRSRERR 323
                 ++++ R  E          +  R +D           +     D  R    E++
Sbjct: 177 MPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIQIREKLDQLRKTVAEKQ 236

Query: 324 RSRSRDR-RRSRSHDRSERKHR---SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEK 379
             R++DR RR    +R ER  R   SR+RDRRRS+SRDR+  + RS SR+R +  +S+ +
Sbjct: 237 EKRNQDRLRRREEREREERLSRRSGSRTRDRRRSRSRDRRRRRSRSTSRERRKLSRSRSR 296

Query: 380 EKRGSDDKKSSVKSGSREKQSEDTNTESK 408
           ++      +S   S    + S D + + K
Sbjct: 297 DRHRRHRSRSRSHSRGHRRASRDRSAKYK 325


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score =  135 bits (339), Expect = 9e-32
 Identities = 72/180 (40%), Positives = 109/180 (60%), Gaps = 3/180 (1%)

Query: 223 IKATVEELKEKLRKRTEEPDRDERLKKE-KQEREEREKEREREREERERKRRRE-EEERE 280
           I   + + ++  +K  EE  + E+ ++E ++ER ERE+ERERERE RER+R RE E ERE
Sbjct: 277 ISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERERE 336

Query: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340
           KE+ R+RE R+R R R R   R  DR   R RD  R RS +R + RSR R +SR  +R  
Sbjct: 337 KEKERERE-RERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERER 395

Query: 341 RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
            + R R R+R R + R+R+  + R + R+RE+D+K   +E      ++  ++   REK++
Sbjct: 396 EREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEA 455



 Score =  132 bits (331), Expect = 8e-31
 Identities = 77/228 (33%), Positives = 120/228 (52%), Gaps = 16/228 (7%)

Query: 221 AKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRRE-EEER 279
           +K + T ++L+E+  K+ +E    E+ ++E++   ERE+ER     ERER+R RE E+ER
Sbjct: 282 SKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKER 341

Query: 280 EKERARDRER-RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR 338
           E+ER RDR+R R + R R R   R  DR   RS D  + RSR R +SR R+R R R  +R
Sbjct: 342 ERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERER 401

Query: 339 SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQD-----------RKSKEKEKRGSDDK 387
              + R R R+R R + R+R+  + + K RDRE+D           RK +EKE    +  
Sbjct: 402 EREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERL 461

Query: 388 KS---SVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
           K+     +  +RE + E    E +  +   E     E ++   D + +
Sbjct: 462 KNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDD 509



 Score =  125 bits (315), Expect = 6e-29
 Identities = 71/184 (38%), Positives = 107/184 (58%), Gaps = 9/184 (4%)

Query: 227 VEELKEKLRKRTEEPDRD--ERLKKEKQEREEREKEREREREERERKRRREEEEREKERA 284
           +EE K  L  R     RD  ++L++EK ++E+  +E E+ER ERER+R RE E RE+ER 
Sbjct: 269 MEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERE 328

Query: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
           R+RER      R +   R  +R   R RD  + R R+R R R RDR R RS DR+  K R
Sbjct: 329 RERERE-----REKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRN--KDR 381

Query: 345 SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTN 404
           SRSR++ R + R+R+  + R + R+RE++R+ + + +R  + ++   K   RE+  ED  
Sbjct: 382 SRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAY 441

Query: 405 TESK 408
              K
Sbjct: 442 ERRK 445



 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 77/279 (27%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQERE-EREKERERERE-ERERKRRREEE---EREKE 282
           +E +E+ R+R  E +R ER ++ ++ERE E+EKERERERE +R+R R +E +   +RE++
Sbjct: 307 KERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERD 366

Query: 283 RARDRER---RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRS 339
           R RDRER   R + RSRSR  SR  +R   R R+ +R R RER R R R+R R R  +R 
Sbjct: 367 RDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERERERE 426

Query: 340 ERKHRSRSRD------------------------------------------------RR 351
           + K R R  D                                                RR
Sbjct: 427 KDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERR 486

Query: 352 RSKSRDRKSYKH--------------------RSKSRDREQDRKSKEKEKRGSDDKKSSV 391
           R  +++ K  K                     + + RDRE++ ++ E++++   ++   +
Sbjct: 487 REMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEI 546

Query: 392 KSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQ 430
           +     +   D + E +  + + E       IK E +++
Sbjct: 547 RQRLLAEGHPDPDAELQRMEQEAE-RRRQPQIKQEPESE 584



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 91/384 (23%), Positives = 163/384 (42%), Gaps = 74/384 (19%)

Query: 101 RRGHARLALSQNQQSSGAAGPT--GKNEEK-----IQVLTDKIDVLLQQIEELGSEGKVE 153
           R+ H  L   +N ++ G       G   EK     I+ L  K  ++L      G+ GK++
Sbjct: 68  RKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQ 127

Query: 154 --------EAQGMMKLVEQLKE----ERELL----RSTTSTIESFAAQEKQMEVCEVCGA 197
                   E +  ++ +  L +    E++LL      T + ++ + A++K          
Sbjct: 128 AFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASN--GNARP 185

Query: 198 FLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREE- 256
             +  D +  +D+    +  M    I+  + E   +L   ++E D   R KK+K+++E+ 
Sbjct: 186 ETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPR-KKKKEKKEDI 244

Query: 257 ----------------REKEREREREE-------------RERKRRREEEEREKERAR-- 285
                           +E     E EE             R+  ++ EEE+ +KE+ R  
Sbjct: 245 FRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQE 304

Query: 286 -DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
            ++ERR+R R R R   R         R+ +R R RER R + ++R R R  DR   + +
Sbjct: 305 IEKERRERERERERERER---------REREREREREREREKEKERERERERDRDRDRTK 355

Query: 345 SRSRDRRRSKSRDR------KSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREK 398
            R RDR R + RDR         K RS+SR++ +DR+ + + +R  + ++   +   RE+
Sbjct: 356 ERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERER 415

Query: 399 QSEDTNTESKESDTKNEVNGTSED 422
           + E      +E D K +     ED
Sbjct: 416 EREREREREREKDKKRDREEDEED 439



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 56/209 (26%), Positives = 99/209 (47%), Gaps = 29/209 (13%)

Query: 228 EELKEKLRKRTEEPDRD-ERLKKEKQERE-EREKEREREREERERKRRREEEEREKERAR 285
           E  +E+ R+R  E +R+ ER ++ ++ERE +++++RE + E+   +R+ E + REKE A 
Sbjct: 398 EREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAY 457

Query: 286 DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSR------SRDRRRSRSHDRS 339
            +ER K    R R  +R  ++   R  + +R  ++E +R +        DR   + +  S
Sbjct: 458 -QERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS 516

Query: 340 ERKHRSRSRDRR-RSKSRDRKSYKHRSK------------SRDREQDRKSKEKEKRGSDD 386
             + R R R++   +  RDRK  K   +              D E  R  +E E+R    
Sbjct: 517 ALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQ 576

Query: 387 KKSSVKSGSREKQSEDTNTESKESDTKNE 415
            K       +E +SE+   E +E + K E
Sbjct: 577 IK-------QEPESEEEEEEKQEKEEKRE 598



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 55/210 (26%), Positives = 92/210 (43%), Gaps = 11/210 (5%)

Query: 228 EELKEKLRKRTE-EPDRDERLKKEK--QEREEREKEREREREERERKRRRE-EEEREKER 283
           E  K+K R R E E D  ER K E+  +E+E   +ER +  E RERK+ RE E+E E+E 
Sbjct: 424 EREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE 483

Query: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH 343
            R RE  K ++          D      RD  +       + R RDR +    D  +RK 
Sbjct: 484 ERRREMAKEAKRLKEFLEDYDD-----DRDDPKYYRGSALQKRLRDREKEMEADERDRKR 538

Query: 344 RSRSRD--RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSE 401
                +  R+R  +          +  ++E +R+ + + K+  + ++   +   +E++ E
Sbjct: 539 EKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKRE 598

Query: 402 DTNTESKESDTKNEVNGTSEDIKSEGDTQS 431
           +   E +E + K  +  T   I S     S
Sbjct: 599 EPMEEEEEPEQKPCLKPTLRPISSAPSVSS 628



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 35/161 (21%), Positives = 70/161 (43%), Gaps = 13/161 (8%)

Query: 222 KIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREK 281
           K++      +E+L+       +  R  +++ EREE E+ RE  +E +  K   E+ + ++
Sbjct: 449 KLREKEAAYQERLKNWEIRERKKTREYEKEAEREE-ERRREMAKEAKRLKEFLEDYDDDR 507

Query: 282 ERAR-DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340
           +  +  R    + R R R     +D      RD KR +  E    R R          +E
Sbjct: 508 DDPKYYRGSALQKRLRDREKEMEAD-----ERDRKREK-EELEEIRQRLLAEGHPDPDAE 561

Query: 341 RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEK 381
            +   +  +RRR     +   K   +S + E++++ KE+++
Sbjct: 562 LQRMEQEAERRR-----QPQIKQEPESEEEEEEKQEKEEKR 597



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 15/51 (29%), Positives = 31/51 (60%)

Query: 221 AKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERK 271
           A+++   +E + + + + ++    E  ++EKQE+EE+ +E   E EE E+K
Sbjct: 560 AELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 17/63 (26%), Positives = 36/63 (57%), Gaps = 3/63 (4%)

Query: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283
           K  +EE++++L      PD D  L++ +QE E R + + ++  E E +   EE++ ++E+
Sbjct: 540 KEELEEIRQRLLAEGH-PDPDAELQRMEQEAERRRQPQIKQEPESEEEE--EEKQEKEEK 596

Query: 284 ARD 286
             +
Sbjct: 597 REE 599


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score =  125 bits (313), Expect = 1e-28
 Identities = 67/210 (31%), Positives = 116/210 (55%), Gaps = 13/210 (6%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRRREEE---EREKER 283
           E  +E+ R+R  E + + + + +++   +R+ ERERE++ ERER   RE E   ERE+ER
Sbjct: 207 ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERER 266

Query: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH 343
            RDR+R +R + R R + R   RR  R R+ +R R R+R R R R+R R R  +R   + 
Sbjct: 267 DRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERE 326

Query: 344 RSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKS---------KEKEKRGSDDKKSSVKSG 394
           R R R+  R + ++R+  + R    DRE++R++         +E+E+    D++S+ +  
Sbjct: 327 RERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSARERE 386

Query: 395 SREKQSEDTNTESKESDTKNEVNGTSEDIK 424
            RE+  +    + +E  T+ + +G  E  K
Sbjct: 387 ERERDRDRDRQKERERQTEKDRDGQRETEK 416



 Score =  124 bits (310), Expect = 2e-28
 Identities = 67/175 (38%), Positives = 103/175 (58%), Gaps = 4/175 (2%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDR 287
           E   ++ R+R  E DR+   K+E+Q   ERE+ER R+RE RER+R R E ER++E  RDR
Sbjct: 280 ERQTDRKRQRRTERDRETERKRERQRERERERERNRKRE-RERERER-ERERQRETERDR 337

Query: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSER-KHRSR 346
           E ++R R R R +    +R     R+ +R   RER R R RDR+ +R  +  ER + R R
Sbjct: 338 E-KERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDR 396

Query: 347 SRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSE 401
            ++R R   +DR   +   K R+RE+DR+S+   +RG + +K   +   RE+Q++
Sbjct: 397 QKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTD 451



 Score =  118 bits (295), Expect = 1e-26
 Identities = 68/192 (35%), Positives = 113/192 (58%), Gaps = 9/192 (4%)

Query: 231 KEKLRKRTEEPDRDERLKKEK-QERE-EREKERERERE-ERERKRRREEEEREKERARDR 287
           +E+ R+R  E +R+++ ++E+  ERE ER+KERERER+ +R+R RR++E ER+ +R R R
Sbjct: 230 RERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289

Query: 288 ER---RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
                R+  R R R   R  +R  +R R+ +R R RER R R  +R R +  +R  ++  
Sbjct: 290 RTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQT 349

Query: 345 SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKS-KEKEKRGSDDKKSSVKSGSREKQSEDT 403
              R+R R   R+ +    R + R+RE+DR+S +E+E+R  D  +   K   RE+Q+E  
Sbjct: 350 EMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQK--ERERQTEKD 407

Query: 404 NTESKESDTKNE 415
               +E++ + E
Sbjct: 408 RDGQRETEKQRE 419



 Score =  113 bits (283), Expect = 3e-25
 Identities = 63/213 (29%), Positives = 114/213 (53%), Gaps = 10/213 (4%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRRREEE-EREKERAR 285
           E  +EK R R  +  R+ +  +EK+   + ++ER+R+RE ER R++ RE E ERE ER R
Sbjct: 80  ERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGR 139

Query: 286 DRE---RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR---- 338
           DR+   +R+R R R     R       R R  +R+R +ER R ++R  RR R   R    
Sbjct: 140 DRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKEN 199

Query: 339 -SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSRE 397
            +E +H  R R+R R +  + ++ + R   R+R++ RK++ + ++ ++ +++S +   R+
Sbjct: 200 KTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERD 259

Query: 398 KQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQ 430
           K+ E      ++ D + +      D K +  T+
Sbjct: 260 KERERERDRDRDRDRRQKERERQTDRKRQRRTE 292



 Score =  113 bits (283), Expect = 3e-25
 Identities = 65/197 (32%), Positives = 105/197 (53%), Gaps = 19/197 (9%)

Query: 232 EKLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRRREEEEREKERARDRER- 289
           EK R+R  + +R  + ++ +Q+  EREK R+  RE ER+R++  + E+R  ER R+RER 
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215

Query: 290 --------RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSER 341
                   RKR   R R   R ++R   +  + +R+  RE  R + R+R R R  DR  R
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275

Query: 342 -KHRSRSRDRRRSK--SRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREK 398
            K R R  DR+R +   RDR++ + R + R+RE++R+   K +R  + ++       RE+
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERER------ERER 329

Query: 399 QSEDTNTESKESDTKNE 415
           Q E      KE + K +
Sbjct: 330 QRETERDREKERERKRK 346



 Score =  112 bits (280), Expect = 7e-25
 Identities = 68/220 (30%), Positives = 111/220 (50%), Gaps = 31/220 (14%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKERERERE-----------ERERKR------- 272
           +EK R+R  + +RD + +KE+  ++ERE+E ERE E           ERER+R       
Sbjct: 101 REKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERE 160

Query: 273 --------RREEEEREKERARDR---ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRE 321
                   R+ E  R+KER R++   ERR+R R R + + +T DR   R R+ +R R  E
Sbjct: 161 RQTDRERQRQTERNRQKEREREKNRQERRERERQREKEN-KTEDRHSERGRERERERETE 219

Query: 322 RRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEK 381
               R R   R R   R   + R +  +R R+  R+ +  K R + RDR++DR  ++KE+
Sbjct: 220 TETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKER 279

Query: 382 RGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSE 421
               D+K   ++  R++++E      +E + + E N   E
Sbjct: 280 ERQTDRKRQRRT-ERDRETERKRERQRERERERERNRKRE 318



 Score =  111 bits (278), Expect = 1e-24
 Identities = 63/200 (31%), Positives = 106/200 (53%), Gaps = 3/200 (1%)

Query: 218 MGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEE 277
           +G   ++ T+     + R  ++E  R   L +  ++ +  ++ER R++E RER+R + + 
Sbjct: 13  LGTLWVEVTIPLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKE-RERRREKRQT 71

Query: 278 EREKERARDRERRK-RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSH 336
           ERE +R R+R R K R R R RH  R  DR   R R   R R R+R + R+R + R R  
Sbjct: 72  ERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERET 131

Query: 337 DRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSR 396
           +R   + R R  D +R + R R + K R +  DRE+ R+++   ++  + +K+  +   R
Sbjct: 132 EREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRER 191

Query: 397 EKQSEDTN-TESKESDTKNE 415
           E+Q E  N TE + S+   E
Sbjct: 192 ERQREKENKTEDRHSERGRE 211



 Score =  111 bits (277), Expect = 1e-24
 Identities = 66/206 (32%), Positives = 111/206 (53%), Gaps = 19/206 (9%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREE-RERKRRREEE-EREKERAR 285
           E  ++K R+R  E  + ER    K+ER  REK+R R+R+  RER+R RE+E ER+ +R R
Sbjct: 55  ERNRQKERERRREKRQTERETDRKRERR-REKDRHRKRDRHRERQRDREKERERQTDRER 113

Query: 286 DRERRK-------RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR 338
           DR+R K       R R   R   R  DR+    R+ +R R  E+ R R  DR R R  +R
Sbjct: 114 DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTER 173

Query: 339 SERKHRSRSRDRRRSKSRDRKSYK---------HRSKSRDREQDRKSKEKEKRGSDDKKS 389
           + +K R R ++R+  + R+R+  K          R + R+RE++ +++ + KR +D ++ 
Sbjct: 174 NRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERD 233

Query: 390 SVKSGSREKQSEDTNTESKESDTKNE 415
             +   RE++ +     + E +T+ +
Sbjct: 234 RQRKTEREREKQAERERASERETERD 259



 Score =  110 bits (274), Expect = 3e-24
 Identities = 61/179 (34%), Positives = 101/179 (56%), Gaps = 9/179 (5%)

Query: 239 EEPDRDERLKKEKQEREEREKERERERE-ERERKRRREEE-----EREKERARDRER-RK 291
           ++ D D+R +  ++ERE R ++R+ ERE +R+R+RRRE++     +R +ER RDRE+ R+
Sbjct: 47  KDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERE 106

Query: 292 RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRR 351
           R   R R   R  +R   + R+ +  R  ER R R  D +R R   R   K R R  DR 
Sbjct: 107 RQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRE 166

Query: 352 RSKSRDRKSYKHRSKSRDREQDR-KSKEKEKRGSDDKKSSVKSGSREKQSE-DTNTESK 408
           R +  +R   K R + ++R++ R + +++EK    + + S +   RE++ E +T TE K
Sbjct: 167 RQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERK 225



 Score =  109 bits (272), Expect = 6e-24
 Identities = 58/191 (30%), Positives = 102/191 (53%), Gaps = 7/191 (3%)

Query: 232 EKLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRRRE-EEEREKERARDRER 289
           E+ R R  +  R+   +++ ++  ER+ +RER+R+ ER R++ RE E+ R++ R R+R+R
Sbjct: 136 ERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQR 195

Query: 290 RKRSRSRSRHSSRTSDRRCSR----SRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRS 345
            K +++  RHS R  +R   R      + KR   RER R R  +R R +  +R     R 
Sbjct: 196 EKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERE 255

Query: 346 RSRDRRRSKSRDR-KSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTN 404
             RD+ R + RDR +    R K R+R+ DRK + + +R  + ++   +   RE++ E   
Sbjct: 256 TERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNR 315

Query: 405 TESKESDTKNE 415
              +E + + E
Sbjct: 316 KRERERERERE 326



 Score =  107 bits (266), Expect = 3e-23
 Identities = 61/165 (36%), Positives = 96/165 (58%), Gaps = 8/165 (4%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKER--ERERE-ERERKRRREEE-EREKER 283
           E  +E+ R+R  E +R+ + ++E++   ERE++R  ER+RE ERERKR+R+ E +RE+ R
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNR 357

Query: 284 ARDRERRK---RSRSRSRHSSRTSDR-RCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRS 339
              RE R+   R R R R   R S R R  R RD  R R +ER R   +DR   R  ++ 
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ 417

Query: 340 ERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGS 384
             + + R  +R R + R+R+  K R + R+R+ DR++  + KR +
Sbjct: 418 REREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRST 462



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 52/192 (27%), Positives = 93/192 (48%), Gaps = 6/192 (3%)

Query: 231 KEKLRKRTEEPDRD-ERLKKEKQEREEREKERERERE-ERERKRRREEE-EREKERARDR 287
           +E  R+   E +R+ ER ++  +EREERE++R+R+R+ ERER+  ++ + +RE E+ R+R
Sbjct: 361 REGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQRER 420

Query: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS 347
           E+ + S  R R   R  +++  R RD +R   R+  R R R         R+ R    +S
Sbjct: 421 EKDRES-ERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQS 479

Query: 348 RDRRRSKSRDRKSYKHRSKSRDRE--QDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNT 405
              R ++    KS     K+        R +K    R +  ++   + G +  Q  +   
Sbjct: 480 DPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPRLGEKRGQGGEGRR 539

Query: 406 ESKESDTKNEVN 417
            S    T+N ++
Sbjct: 540 PSGGFGTENPLS 551



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 57/192 (29%), Positives = 91/192 (47%), Gaps = 19/192 (9%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQERE-----EREKERERERE-------ERERKRRRE 275
           E  ++  R+R  E +RD +  +E++ERE     +R+KERER+ E       E E++R RE
Sbjct: 362 EGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQRERE 421

Query: 276 ---EEEREKERARDRERRK-RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRS--RSRD 329
              E ER +ER R+RE++K R R R R + R + R+  RS  +     R  R    +S  
Sbjct: 422 KDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDP 481

Query: 330 RRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKS 389
            R +R           ++   R    R  K+ + R   R R + R   EK  +G + ++ 
Sbjct: 482 NRPTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPRLG-EKRGQGGEGRRP 540

Query: 390 SVKSGSREKQSE 401
           S   G+    S+
Sbjct: 541 SGGFGTENPLSQ 552


>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 202

 Score =  121 bits (303), Expect = 1e-27
 Identities = 70/194 (36%), Positives = 105/194 (54%), Gaps = 18/194 (9%)

Query: 232 EKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEE---EREKERARDRE 288
           E+ R+R  E DR +  ++E+  + ERE + ERE   R+R R RE +   +REKER R +E
Sbjct: 2   ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61

Query: 289 RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRS--- 345
           R  R R R R + R ++R+  R R  +R R  +R R + RDR R R  DR+  ++R    
Sbjct: 62  R-DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGR 120

Query: 346 -------RSRDRRRSKSRDRKSYKHRSKSRDREQDRKSK---EKEKRGSDDKKSSVKSGS 395
                  R RDR R + R R+  + R + R RE DR+ +   E+E+R  + KK   K   
Sbjct: 121 ERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKER-KKER 179

Query: 396 REKQSEDTNTESKE 409
           +EK+ E+   E K+
Sbjct: 180 KEKKKEEKRREDKK 193



 Score =  115 bits (287), Expect = 1e-25
 Identities = 63/166 (37%), Positives = 104/166 (62%), Gaps = 6/166 (3%)

Query: 226 TVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRRRE-EEEREKER 283
           T  E + + R R  E DR    +KE++ ++ER+++R+RERE ERE +R+RE + +RE++R
Sbjct: 31  TERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERETERQRERQRQRERKR 90

Query: 284 ARDRERRK-RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERK 342
             DRER K R R R R + R  +R  +R    +R +  ER R R R+R+R R  +R  ++
Sbjct: 91  QTDRERDKDRDRERKRETDRNRER--NRKGGRERDKQTERERDRERERQRQRERERQRQR 148

Query: 343 HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKK 388
            R R  DR R +  +R+  K + + ++R+++RK K+KE++  +DKK
Sbjct: 149 ERKRETDRERQRWAEREERK-KERKKERKKERKEKKKEEKRREDKK 193



 Score =  114 bits (286), Expect = 1e-25
 Identities = 65/180 (36%), Positives = 106/180 (58%), Gaps = 11/180 (6%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQERE-EREKERERERE---ERERKRRREEE-EREKE 282
           E  +++ R+R  + +R+ R ++  + RE +R+ +RE+ERE   ER+R+R+RE E ERE E
Sbjct: 18  ERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERETE 77

Query: 283 RARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERK 342
           R R+R+ R+R R R     R  DR   R R+  R+R R R+  R RD++  R  DR   +
Sbjct: 78  RQRERQ-RQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRERER 136

Query: 343 HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSED 402
            R R R+R+R + R R++ + R +  +RE+ +K ++KE+     KK   +    EK+ ED
Sbjct: 137 QRQRERERQRQRERKRETDRERQRWAEREERKKERKKER-----KKERKEKKKEEKRRED 191



 Score =  110 bits (274), Expect = 3e-24
 Identities = 56/189 (29%), Positives = 98/189 (51%), Gaps = 2/189 (1%)

Query: 240 EPDRDERLKKEKQEREEREKEREREREER-ERKRRREEEEREKERARDRERRK-RSRSRS 297
           E  R+ + + ++ +  ERE++R+RERE + ER+ R  + +R +ER R  +R K R R + 
Sbjct: 2   ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61

Query: 298 RHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRD 357
           R   R  +R   R  + +R R R+R R R  DR R +  DR  ++   R+R+R R   R+
Sbjct: 62  RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121

Query: 358 RKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVN 417
           R     R + R+RE+ R+ + + +R  + K+ + +   R  + E+   E K+   K    
Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKE 181

Query: 418 GTSEDIKSE 426
              E+ + E
Sbjct: 182 KKKEEKRRE 190



 Score =  109 bits (272), Expect = 6e-24
 Identities = 55/152 (36%), Positives = 91/152 (59%), Gaps = 5/152 (3%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKR-RREEEEREKERARDRE 288
           +E+ R+   E +R+ + ++++Q + ERE ERE ER+ ER+R+R R+ + +RE+++ RDRE
Sbjct: 44  RERDRQTDREKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRE 103

Query: 289 RRK---RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRS 345
           R++   R+R R+R   R  D++  R RD +R R R+R R R R R R R  DR  ++   
Sbjct: 104 RKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAE 163

Query: 346 RSRDRRRSKSRDRKSYKHRSKSRDREQDRKSK 377
           R   ++  K   +K  K + K   R +D+K K
Sbjct: 164 REERKKERKKERKKERKEKKKEEKRREDKKRK 195



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 41/141 (29%), Positives = 73/141 (51%), Gaps = 10/141 (7%)

Query: 215 KQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRR 274
           +Q     + +   E  +E+ R+R  +   D    K++    +RE +R RER  +  + R 
Sbjct: 64  RQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERD 123

Query: 275 EEEEREKERARDRER-RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRS 333
           ++ ERE++R R+R+R R+R R R R   R +DR        +R R  E R  R ++R++ 
Sbjct: 124 KQTERERDRERERQRQRERERQRQRERKRETDR--------ERQRWAE-REERKKERKKE 174

Query: 334 RSHDRSERKHRSRSRDRRRSK 354
           R  +R E+K   + R+ ++ K
Sbjct: 175 RKKERKEKKKEEKRREDKKRK 195



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 31/118 (26%), Positives = 64/118 (54%), Gaps = 1/118 (0%)

Query: 310 RSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRD 369
           R R+ KR   R +   R RDR+R R + ++ER++R R RDR R + R     K R + ++
Sbjct: 3   RQRERKRETDRGKETERERDRQREREN-QTERENRHRQRDRHRERDRQTDREKERERQKE 61

Query: 370 REQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEG 427
           R++ R+ + + +R ++ ++   +   R++Q++    + ++ + K E +   E  +  G
Sbjct: 62  RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGG 119



 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 22/92 (23%), Positives = 54/92 (58%)

Query: 205 QSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERE 264
           + R  D    +   G  +     E  +++ R+R  + +R+ + ++E++   +RE++R  E
Sbjct: 104 RKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAE 163

Query: 265 REERERKRRREEEEREKERARDRERRKRSRSR 296
           REER+++R++E ++  KE+ ++ +RR+  + +
Sbjct: 164 REERKKERKKERKKERKEKKKEEKRREDKKRK 195


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score =  118 bits (295), Expect = 1e-26
 Identities = 60/190 (31%), Positives = 110/190 (57%), Gaps = 5/190 (2%)

Query: 243 RDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSR 302
           R+   KKE++ERE+R++ERE+ER+ RER ++ +++ +++ER ++RER+++ R + R   R
Sbjct: 32  RESERKKERREREKRKREREKERK-RERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90

Query: 303 TSDRRCSRSRDHKRSRSRERRRSRSRDR-RRSRSHDRSERKHRSRSRDRRRSKSRDRKSY 361
             +RR  +    KR R +  RR R + + R+ R  +  +R+ R R + R++ + ++RK  
Sbjct: 91  EKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKRE 150

Query: 362 KHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSE 421
           K R K   + + RK +E+EK+   ++K   K   R+++ E      KE   K E     +
Sbjct: 151 KERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKE---RKK 207

Query: 422 DIKSEGDTQS 431
           D K++  T S
Sbjct: 208 DRKTDRQTDS 217



 Score =  112 bits (280), Expect = 7e-25
 Identities = 57/192 (29%), Positives = 108/192 (56%), Gaps = 3/192 (1%)

Query: 226 TVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREE-RERKRRREEEEREKERA 284
           T  E + K  +R  E  + ER K+ K+ER ++EK++ ++RE  +ER+R+R+E E++++  
Sbjct: 30  TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89

Query: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
           R++ERRKR + + +   +   RR  + +  ++ R RE ++ R R R++ R   R + + R
Sbjct: 90  REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKR 149

Query: 345 SRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTN 404
            + R +R  K + RK  + R K R+R +  + KE+E++   ++K   K   R K+ E   
Sbjct: 150 EKERGKRERKRKKRKK-EEREKKRERNRKERKKERERKERRERKKERKK-ERRKKKERKK 207

Query: 405 TESKESDTKNEV 416
               +  T ++V
Sbjct: 208 DRKTDRQTDSQV 219



 Score =  103 bits (256), Expect = 4e-22
 Identities = 48/167 (28%), Positives = 99/167 (59%), Gaps = 1/167 (0%)

Query: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283
           K    E  +K +K+ ++ +R +  +++++ERE++ KER RE+E R+RK+ +++ ER++  
Sbjct: 52  KERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER-REKERRKRKKEKKKRERKQRG 110

Query: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH 343
            R+R+++K  + R R + +  +R+  + R  KR + R+R + R +  R+ +   + ER+ 
Sbjct: 111 RRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREK 170

Query: 344 RSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSS 390
           +     + R K R+RK  + R K R +E+ +K + K+ R +D +  S
Sbjct: 171 KRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDS 217



 Score =  100 bits (249), Expect = 3e-21
 Identities = 55/156 (35%), Positives = 93/156 (59%), Gaps = 5/156 (3%)

Query: 228 EELKEKLRKRTE-EPDRDERLKKEKQER--EEREKER-EREREERERKRRREEEEREKER 283
           E  KE+ RKR E E  R ER +KE+++R  E++++ER +R R ER++K+ R+E ERE ++
Sbjct: 70  ERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQ 129

Query: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR-RSRSHDRSERK 342
            R+R+R+KR + + R   +    R  R R  K+ +  ER + R R+R+ R +  +R ER+
Sbjct: 130 RRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERR 189

Query: 343 HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKE 378
            R + R + R K ++RK  +   +  D +  R  +E
Sbjct: 190 ERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRE 225



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 43/149 (28%), Positives = 80/149 (53%), Gaps = 20/149 (13%)

Query: 215 KQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRR 274
           K+     K K   E  +   R+R ++ +R ER ++ KQ RE + K+R +++  +ERKR +
Sbjct: 92  KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK 151

Query: 275 EEEEREKER-ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRS 333
           E  +RE++R  R +E R++ R R+R             ++ K+ R R+ RR R ++R++ 
Sbjct: 152 ERGKRERKRKKRKKEEREKKRERNR-------------KERKKERERKERRERKKERKKE 198

Query: 334 RSHDRSERKHRSRSRDRRRSKSRDRKSYK 362
           R      RK + R +DR+  +  D + ++
Sbjct: 199 R------RKKKERKKDRKTDRQTDSQVFR 221


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score =  118 bits (295), Expect = 1e-26
 Identities = 73/209 (34%), Positives = 116/209 (55%), Gaps = 12/209 (5%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEE-EREKERARD 286
           +E +E+ R    +  RDER ++  +ERE R++ERERERE RER R RE+E E E+ERAR+
Sbjct: 657 DERREERRVDRVDDRRDERARERDRERE-RDRERERERE-RERDREREKERELERERARE 714

Query: 287 RER-RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRER---RRSRSRDRRRSRSHDRSERK 342
           RER R++ R R R   R  DR   R R+  R + RER    R R R+R R R  +R   +
Sbjct: 715 REREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERER 774

Query: 343 HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSED 402
            R+R RD+ R + RD   ++ + K RD  ++++ + +E R   D     K  S+++   +
Sbjct: 775 ERARERDKERERQRD---WEDKDKGRDDRREKREEIREDRNPRDGHDERK--SKKRYRNE 829

Query: 403 TNTESKESDTKNEVNGTSEDIKSEGDTQS 431
            +   ++S  +   +    D  + GD ++
Sbjct: 830 GSPSPRQSPKRRREHSPDSDAYNSGDDKN 858



 Score =  113 bits (283), Expect = 3e-25
 Identities = 66/200 (33%), Positives = 108/200 (54%), Gaps = 24/200 (12%)

Query: 235 RKRTEEPDRDERL--------KKEKQEREEREKEREREREERERKRRREEEEREKERARD 286
           R R +  +RD+R         + ++ ER+ER +ER  +R +  R  R  E +RE+ER R+
Sbjct: 629 RDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRE 688

Query: 287 RER-RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRS------ 339
           RER R+R R R R   R  +R  +R R+ +R + R+R R R RD  R R  +R       
Sbjct: 689 RERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKE 748

Query: 340 ---ERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEK-RGSDDKKSSVKSGS 395
              ER+ R R R+R R + R+R+  + R++ RD+E++R+   ++K +G DD++       
Sbjct: 749 REREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRRE-----K 803

Query: 396 REKQSEDTNTESKESDTKNE 415
           RE+  ED N      + K++
Sbjct: 804 REEIREDRNPRDGHDERKSK 823



 Score =  110 bits (275), Expect = 2e-24
 Identities = 73/202 (36%), Positives = 109/202 (53%), Gaps = 20/202 (9%)

Query: 227 VEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERERE---ERERKRRRE-EEEREKE 282
           V+ + ++  +R  E DR+    +E++   ERE++RERE+E   ERER R RE E E+E++
Sbjct: 665 VDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERD 724

Query: 283 RARDRER-----RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHD 337
           R RDR+R     R+R R R R   R  +R   R R+ +R R RER R R R+R R R  +
Sbjct: 725 RERDRDRDHDRERERERERDREKERERERE-ERERERERERERERERERERERARERDKE 783

Query: 338 RSERK---HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEK-EKRGSDDKKSSVKS 393
           R  ++    + + RD RR K   R+  +     RD   +RKSK++    GS   + S K 
Sbjct: 784 RERQRDWEDKDKGRDDRREK---REEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPK- 839

Query: 394 GSREKQSEDTNTESKESDTKNE 415
             R + S D++  +   D KNE
Sbjct: 840 -RRREHSPDSDAYN-SGDDKNE 859



 Score =  105 bits (262), Expect = 8e-23
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 23/243 (9%)

Query: 202 GDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRD---ERLKKEKQEREERE 258
           G   S++D H     +    + +++  E      +   +  RD   ER   E+  R+ RE
Sbjct: 577 GSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRE 636

Query: 259 KER-------------EREREERERKRRREE-EEREKERARDRER---RKRSRSRSRHSS 301
           +++             E ER+ER  +RR +  ++R  ERAR+R+R   R R R R R   
Sbjct: 637 RDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERE 696

Query: 302 RTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS- 360
           R  +R   R  + +R+R RER R + RDR R R  D    + R R RDR + + R+R+  
Sbjct: 697 RDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREER 756

Query: 361 YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKES--DTKNEVNG 418
            + R + R+RE++R+ + +  R  D ++   +    + +  D   E +E   + +N  +G
Sbjct: 757 ERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDG 816

Query: 419 TSE 421
             E
Sbjct: 817 HDE 819



 Score =  101 bits (252), Expect = 1e-21
 Identities = 57/195 (29%), Positives = 92/195 (47%), Gaps = 10/195 (5%)

Query: 237 RTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSR 296
           R+  P+RD   +++ ++ + R+   ER   ER+R+  RE ++R     R + R       
Sbjct: 599 RSSYPERDRYPERDNRD-QARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERD 657

Query: 297 SRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSR 356
            R   R  DR   R  +  R R RER R R R+R R R  DR   K R   R+R R + R
Sbjct: 658 ERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERER 717

Query: 357 DRKSYKHRSKSRDREQDR---------KSKEKEKRGSDDKKSSVKSGSREKQSEDTNTES 407
           +R+  + R + RDR+ DR         + KE+E+   + ++   +   RE++ E     +
Sbjct: 718 EREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERA 777

Query: 408 KESDTKNEVNGTSED 422
           +E D + E     ED
Sbjct: 778 RERDKERERQRDWED 792



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 108/418 (25%), Positives = 173/418 (41%), Gaps = 67/418 (16%)

Query: 16  RNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDEN--------LR 67
           RN + +E RS +R D     +    G  P      +R   G     H  N         R
Sbjct: 544 RNESRNESRSEIRNDRMGRSR----GRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETR 599

Query: 68  KQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEE 127
             Y +  R+     ERD     Q+  +  ERR      R    ++Q+ S      G+N+E
Sbjct: 600 SSYPERDRYP----ERD--NRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDE 653

Query: 128 ----------KIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTS 177
                     ++  + D+ D   ++ +      +  E +   +   + ++EREL R    
Sbjct: 654 LERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAR 713

Query: 178 TIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKR 237
             E    +E+  E              + R  DH   +            E  +E+ R++
Sbjct: 714 EREREREKERDRE--------------RDRDRDHDRER------------ERERERDREK 747

Query: 238 TEEPDRDERLKKEKQERE-EREKERERER-EERERKRRREEEEREKERARDRERRKRS-- 293
             E +R+ER ++ ++ERE ERE+ERERER  ER+++R R+ +  +K++ RD  R KR   
Sbjct: 748 EREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEI 807

Query: 294 ----RSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRD 349
                 R  H  R S +R          +S +RRR  S D     S D    KHR  S+ 
Sbjct: 808 REDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQV 867

Query: 350 RRRSKSRDRKSYKHRSKSRD---REQDRKSKEKE-KRGSDDKKSSVKSGSREKQSEDT 403
            R  +SR   S  H ++ R    +E+DRK + KE  R  ++++   K  S +KQ E T
Sbjct: 868 VRPQESRS-LSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQT 924



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 60/235 (25%), Positives = 99/235 (42%), Gaps = 29/235 (12%)

Query: 200  IVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREK 259
            I G+ +SR+D    G+     ++  ++  +       R   P+ D ++       + R++
Sbjct: 1243 ITGERKSRIDQLKRGEP----SRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDR 1298

Query: 260  EREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRS 319
             +ER+R E +R+R RE                R  +R R   R +D+   R+RD  R R 
Sbjct: 1299 LQERDRYEHDRERERE----------------RRDTRQREWDRDADKDWPRNRD--RDRL 1340

Query: 320  RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSR-------DREQ 372
            RER R R RD+RR    +R      S  RDR R + R  +S +  S  R       + E+
Sbjct: 1341 RERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHER 1400

Query: 373  DRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEG 427
            D +S  ++    D ++     GS +   E   +E  ES    +     +D  S G
Sbjct: 1401 DLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLG 1455



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 39/160 (24%), Positives = 75/160 (46%)

Query: 271 KRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDR 330
           +R R  E   +++ARD    +R   R R  +R  D+R S    H+       R  R  +R
Sbjct: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER 663

Query: 331 RRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSS 390
           R  R  DR + + R R R+R R + R+R+  + R + R++E++ + +   +R  + +K  
Sbjct: 664 RVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKER 723

Query: 391 VKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQ 430
            +   R++  +      +E D + E     E+ + E + +
Sbjct: 724 DRERDRDRDHDRERERERERDREKEREREREERERERERE 763



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 59/228 (25%), Positives = 92/228 (40%), Gaps = 20/228 (8%)

Query: 211  HLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERER 270
            H  G    G  ++  +    +EK +      +R  R+ + K+    R    +R+      
Sbjct: 1215 HRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHS 1274

Query: 271  KRRREEEEREKERAR----DRERRKRSRSRSRHS-SRTSDRRCSRSRDHKRSRSRERRRS 325
             RR   E   +  +R    D   R + R R  H   R  +RR +R R+  R   ++  R+
Sbjct: 1275 SRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRN 1334

Query: 326  RSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSD 385
            R RDR   R       + R R RD+RR   R+R+     S  RDR++DR    +  +   
Sbjct: 1335 RDRDRL--R------ERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIES 1386

Query: 386  DKKSSVK-SGSREKQSEDTNTESKESDTK------NEVNGTSEDIKSE 426
             K+   K  G  E+  E T+ +S   D +        V G  E  KSE
Sbjct: 1387 VKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSE 1434



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 57/195 (29%), Positives = 88/195 (45%), Gaps = 18/195 (9%)

Query: 235 RKRTEEPDRDERLKKEKQEREEREKERER--------EREERERKRRRE----EEEREKE 282
           R+     D   +  +EK  REERE E+++        +RE R+ + RR+     + RE  
Sbjct: 412 RRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELR 471

Query: 283 RARDRERRKRSRSRSRHSSRTSDRRCSRS-RDHKRSRSRERRRSRSRD---RRRSRSHDR 338
            +RD    +  R  SR +  + D R SRS RD    R RE R +  ++      SRS+ R
Sbjct: 472 DSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGR 531

Query: 339 SE-RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKK-SSVKSGSR 396
           +  R+  SR+  R  S++  R   ++    R R +  +  EK  RGS   +  S  S S 
Sbjct: 532 NHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSN 591

Query: 397 EKQSEDTNTESKESD 411
              S +T +   E D
Sbjct: 592 YHDSWETRSSYPERD 606



 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 50/184 (27%), Positives = 85/184 (46%), Gaps = 14/184 (7%)

Query: 236 KRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRS 295
           +R + P R     +EK   +     +  +R    R+  R + +REK+    RE R+  + 
Sbjct: 383 QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDS---REEREYEQD 439

Query: 296 RSRHSSRTSDRRCSRSRDHKRSR-SRERRRSR-SRDRRRSRSHDRSERKHRSRSRDRRRS 353
           +S       DR     RD + +R +R+RR  R SRD R S       R+ R  SRD + S
Sbjct: 440 QSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDS-------REMRDYSRDTKES 492

Query: 354 KS-RDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDT 412
           +  RD +S +     RDRE  R +  KE    ++ +S  ++  RE+ S         +++
Sbjct: 493 RDPRDSRSTRDAHDYRDRE-GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNES 551

Query: 413 KNEV 416
           ++E+
Sbjct: 552 RSEI 555



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 51/218 (23%), Positives = 91/218 (41%), Gaps = 34/218 (15%)

Query: 249 KEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSD--- 305
           KEK + ++R +E+ R+ ++R R   R+ E+R+K R+     +  S   SRH S +S    
Sbjct: 281 KEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGS 340

Query: 306 --RRCSRSRDHKRS-------------------------RSRERRRSRSRDRRRSRSHDR 338
             +R S S   KR+                          S +R++S  R R   R   R
Sbjct: 341 SIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGR 400

Query: 339 SERKHRSRSRDRRRSKSRDRKSYKHRSKS----RDREQDRKSKEKEKRGSDDKKSSVKSG 394
            + +  S+S DRR  +  D +  + R K     R+ EQD+ S    +   + +    +  
Sbjct: 401 HDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRD 460

Query: 395 SREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
           +R+ +      +S++     E+   S D K   D + +
Sbjct: 461 ARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDS 498



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 53/190 (27%), Positives = 73/190 (38%), Gaps = 17/190 (8%)

Query: 243 RDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSR------ 296
           RD   K++    E R   R   REE  R   R E   E       +R  RSR R      
Sbjct: 513 RDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPE 572

Query: 297 -SRHSSRTS--DRRCSRSRDHK----RSRSRERRRSRSRDRRRSRSHDRSERKHRSRSR- 348
                SR S  D   S S  H     RS   ER R   RD R        ER+H  R R 
Sbjct: 573 KGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRR 632

Query: 349 DRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDK---KSSVKSGSREKQSEDTNT 405
           D R    R     +H+ ++ + E+D + +E+     DD+   ++  +   RE+  E    
Sbjct: 633 DNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERE 692

Query: 406 ESKESDTKNE 415
             +E D + E
Sbjct: 693 RERERDRERE 702



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 53/203 (26%), Positives = 88/203 (43%), Gaps = 22/203 (10%)

Query: 230 LKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRER 289
           ++EK R   E   +    + E+  RE+   +R+RE++ RE +   +++   ++   DRE 
Sbjct: 395 MREKGRHDHERTSQSHDRRHER--REDTRGKRDREKDSREEREYEQDQSSSRDHRDDREP 452

Query: 290 RK-RSRSRSRHSSRTSDRRCSRS-RDHKRSRSRERRRSRSRDRRRSRS----HDRSERKH 343
           R  R R  +R +    + R SR  RD +  R   R    SRD R SRS    HD  +R+ 
Sbjct: 453 RDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREG 512

Query: 344 RSRSR------DRRRSKSRD-------RKSYKHRSKSRDREQDRKSKEKEKRGS-DDKKS 389
           R   R      +  RS  R+       R   ++ S++  R + R  +    RG   +   
Sbjct: 513 RDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPE 572

Query: 390 SVKSGSREKQSEDTNTESKESDT 412
               GSR  Q +  ++ S   D+
Sbjct: 573 KGSRGSRGSQIDSHSSNSNYHDS 595



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 58/248 (23%), Positives = 91/248 (36%), Gaps = 51/248 (20%)

Query: 231 KEKLRKRTEEPDRD--ERLKKEKQEREEREKER--------------------------- 261
           K K++ R EE  RD  +R +  +++RE+R+K R                           
Sbjct: 283 KYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSI 342

Query: 262 EREREERERKR--------------RREEEEREKERARDRERRK---RSRSRSRHSSRTS 304
           +R      RKR              RR             +R++   R RS  R   R  
Sbjct: 343 QRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHD 402

Query: 305 DRRCSRSRDHKRSRSRERR--RSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYK 362
             R S+S D +  R  + R  R R +D R  R +++ +   R    DR     RDR+  +
Sbjct: 403 HERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDAR 462

Query: 363 H---RSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGT 419
               R + RD    R S+E      D K+S     SR  +      + +  DT  + +  
Sbjct: 463 DTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTY 522

Query: 420 SEDIKSEG 427
            E+ +S G
Sbjct: 523 PEESRSYG 530



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 50/213 (23%), Positives = 90/213 (42%), Gaps = 23/213 (10%)

Query: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERE--REERERKRRREEEEREK 281
           K + EE + +  + +    RD+R  ++ ++R +    R+R   R+ R+ +  RE  +  +
Sbjct: 428 KDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSR 487

Query: 282 ERARDRERRKRSRSRSRH---------SSRTSDRRCSRSRDHKRSRSRE---RRRSRSRD 329
           +    R+ R    +R  H         + R  D     SR + R+  RE   R   R+  
Sbjct: 488 DTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNES 547

Query: 330 RRRSRSHDRSERKHRSRSR-------DRRRSKSRDRKSYKHRSKSRDREQDRKS-KEKEK 381
           R  SRS  R++R  RSR R         R S+     S+   S   D  + R S  E+++
Sbjct: 548 RNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDR 607

Query: 382 RGSDDKKSSVKSGSREKQ-SEDTNTESKESDTK 413
               D +   +  S E++  E    +++E D +
Sbjct: 608 YPERDNRDQARDSSFERRHGERDRRDNRERDQR 640



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 53/214 (24%), Positives = 95/214 (44%), Gaps = 31/214 (14%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREE-REKERERE-REERERKRRREEEEREKERAR 285
           E  KE+ R+R  E D+D+     +++REE RE    R+  +ER+ K+R   E     R  
Sbjct: 779 ERDKERERQRDWE-DKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQS 837

Query: 286 DRERRKRSRSRSRHSSRTSDR----------RCSRSRDHKRSRSRERRRSRSRDRRR--- 332
            + RR+ S     ++S               R   SR    S   E R+ R ++  R   
Sbjct: 838 PKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPE 897

Query: 333 ----SRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRS-------KSRDREQDRKSKEKEK 381
               SR ++  E K +  S D++R ++   +S + R+       +S DRE   ++ ++ K
Sbjct: 898 RKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENK 957

Query: 382 RGSDDKKSSVKSGSREKQSEDTNTESKESDTKNE 415
           + +  +K  +K    +K+ +D   E    +T +E
Sbjct: 958 KKAKIQKKPIK----KKKEDDVGIERGNIETTSE 987



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 53/218 (24%), Positives = 94/218 (43%), Gaps = 34/218 (15%)

Query: 231  KEKLRKRTEEPDRDERLKKEK--QEREEREKEREREREERERKRRREEEE-REKERARDR 287
            K +L  +   P     L      ++R+ R KE +R+ E +E  RR EE+E +EK  + D+
Sbjct: 860  KHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDK 919

Query: 288  ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS 347
            +R +     S      S  R      H +S  RE            R+HD +++K + + 
Sbjct: 920  QREQTEILES------SRMRAQDIIGHHQSEDRETS---------DRAHDENKKKAKIQK 964

Query: 348  RDRRRSKSRD----RKSYKHRSK-----SRDREQDRKS---KEKEKRG----SDDKKSSV 391
            +  ++ K  D    R + +  S+     S  + Q +KS   K K+ +G    SD++ +  
Sbjct: 965  KPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQ 1024

Query: 392  KSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDT 429
                R  ++    T+ +  +  N  NG  ED + + DT
Sbjct: 1025 SKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDT 1062



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 52/205 (25%), Positives = 85/205 (41%), Gaps = 30/205 (14%)

Query: 235  RKRTEEPDRDERLKKEKQEREEREKERE------REREERERKRRREEEEREKERARD-- 286
            R R E+ +      ++ Q R+  +++R       R        R R        R+ D  
Sbjct: 1162 RTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQ 1221

Query: 287  --RERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHD------R 338
              R+R   S SR R  +++ +    R     + +  E  RS S DR+ SRSH        
Sbjct: 1222 SGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPE 1281

Query: 339  SERKHRSR-----SRDRRRSKSR---DRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSS 390
            S+R+  SR     SRDR + + R   DR+  + R  +R RE DR + +   R  D     
Sbjct: 1282 SDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRD----- 1336

Query: 391  VKSGSREKQSEDTNTESKESDTKNE 415
             +   RE++ E    + ++ D + E
Sbjct: 1337 -RDRLRERERERERDKRRDLDRERE 1360



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 49/190 (25%), Positives = 81/190 (42%), Gaps = 21/190 (11%)

Query: 235 RKRTEEPDRD--ERLKKEKQEREEREKERERE------REERERKRRREEEERE--KERA 284
           R+  E P  D  ER+K ++Q+ +   ++R  E      R+E  R R RE+E+ +  KER 
Sbjct: 75  RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERT 134

Query: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH- 343
            + E        +R  S   D     + D+    S E +R + +        +  E++  
Sbjct: 135 PESEEENVEWETNRDDSDNGDI----NYDYVHELSLEMKRQKIQRELMKLEQENMEKREE 190

Query: 344 ----RSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQ 399
               +  S +  RSK     S +  SKS  R+   KS    K+  D K S+V S   ++Q
Sbjct: 191 IIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKK--DRKTSAVSSPLLDQQ 248

Query: 400 SEDTNTESKE 409
                 +SK+
Sbjct: 249 RNSKTNQSKK 258



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 46/177 (25%), Positives = 71/177 (40%), Gaps = 40/177 (22%)

Query: 266  EERERKRRREEEEREK------ERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRS 319
            E+  RK  R   E+ +      E A+ R+   + RS S  S+R++           RS +
Sbjct: 1154 EDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSN-----------RSHT 1202

Query: 320  RERRRSRSRDRRRSRSHDRSERKH--RSRSRDRRRSKSRD------------RKSYKHRS 365
              R RS S D       D+S RK    S SRDR ++KS +            ++    RS
Sbjct: 1203 SGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRS 1262

Query: 366  KSRDREQDRKSKEKEKRGSDDKKSSVKSGS---------REKQSEDTNTESKESDTK 413
             S DR+  R    +      D++   +SGS         R++   D   E +  DT+
Sbjct: 1263 TSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTR 1319



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 38/230 (16%)

Query: 216 QHMGYAKIKATVEELKEKLRKRTE-EPDRDER---------LKKEKQEREEREKERERER 265
           +H     IK T E   E   +  E E +RD+          + +   E + ++ +RE  +
Sbjct: 120 RHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMK 179

Query: 266 EERERKRRREEEEREKERARDRERRKRSRSRS-RHSSRTSDRRCS--RSRDHKRSRSRER 322
            E+E   +REE   +KE + +  R K S S S R SS++  R+ S   S   K+ R    
Sbjct: 180 LEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSA 239

Query: 323 RRSRSRDRRRSRSHDRSER----------------------KHRSRSRDRRRSKSRDRKS 360
             S   D++R+   ++S++                      K + + +DR   K+RD K 
Sbjct: 240 VSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKD 299

Query: 361 YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKES 410
              R +  +R+++++ K +    +    S + S      S+  ++  + S
Sbjct: 300 ---RGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHS 346


>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 290

 Score =  117 bits (293), Expect = 2e-26
 Identities = 72/210 (34%), Positives = 108/210 (51%), Gaps = 13/210 (6%)

Query: 202 GDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKER 261
           GD + R  D +  K      + +    E + K ++     DR+++ + E+    E++K R
Sbjct: 74  GDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGR 133

Query: 262 ERERE---ERERKRRREEE-EREKERARDRER-----RKRSRSRSRHSSRTSDRRCSRSR 312
           ERER+   ERER R RE+E ER+ E+ RD +R     R+R R R +   R ++R   R R
Sbjct: 134 ERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQR 193

Query: 313 DHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQ 372
           D ++ R R+  R R R R+      R   +   R  DRRR + RDR     R K RDRE+
Sbjct: 194 DTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDR----DRGKERDRER 249

Query: 373 DRKSKEKEKRGSDDKKSSVKSGSREKQSED 402
           DRK + K++R  + KK   +    EK+ ED
Sbjct: 250 DRKEERKKERKKERKKERKEKKKEEKRRED 279



 Score =  111 bits (278), Expect = 1e-24
 Identities = 63/176 (35%), Positives = 98/176 (55%), Gaps = 17/176 (9%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKERERERE---ERERKRRREEE-----ER 279
           E  + + R++  E +RD   +K+K    ER++ RERER+   E+ER+R+ E++     E 
Sbjct: 108 ETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRET 167

Query: 280 EKERARDRERRK-------RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRR 332
           E ER RDRER K       R R R R + +  +R+  R RD  R R  +  R R  DR  
Sbjct: 168 ETERERDREREKQKERETERDRDRQRDTEKERERQTDRERD--RQRKTQTERQRETDREG 225

Query: 333 SRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKK 388
            R  DR   + R R R + R + RDRK  + + + ++R+++RK K+KE++  +DKK
Sbjct: 226 ERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKK 281



 Score =  105 bits (263), Expect = 6e-23
 Identities = 55/182 (30%), Positives = 100/182 (54%), Gaps = 6/182 (3%)

Query: 239 EEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE---RRKRSRS 295
           ++ D D+R ++  + RE+ EKER+R+R +R+R+RRR+E+E  + R R+++    R R R 
Sbjct: 70  KDADGDDRQRERDRVREKTEKERDRDR-KRDRERRRKEKETNRNRDREKQTEIERDRERE 128

Query: 296 RSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKS 355
           + +   R  DR   R RD  R + RER+  + RD +R    +R   + R + ++R   + 
Sbjct: 129 KQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERD 188

Query: 356 RDRK--SYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTK 413
           RDR+  + K R +  DRE+DR+ K + +R  +  +   +   R ++ +      KE D +
Sbjct: 189 RDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRE 248

Query: 414 NE 415
            +
Sbjct: 249 RD 250



 Score =  102 bits (253), Expect = 9e-22
 Identities = 53/204 (25%), Positives = 105/204 (51%), Gaps = 11/204 (5%)

Query: 218 MGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEE 277
           +G   ++ T+     + R  ++E  R   L +  ++ +  +++R     ER+R R + E+
Sbjct: 36  LGTLWVEVTIPLDFSRGRLGSQESPRSWGLGQAHKDADGDDRQR-----ERDRVREKTEK 90

Query: 278 EREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHD 337
           ER+++R RDRERR++ +  +R+  R       R R+ ++ + RER R R R+R R R  +
Sbjct: 91  ERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDRE 150

Query: 338 RSERKHRSRSRD------RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSV 391
           +   +   + RD        R + R+R+  K R   RDR++ R ++++ +R +D ++   
Sbjct: 151 KERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQ 210

Query: 392 KSGSREKQSEDTNTESKESDTKNE 415
           +    E+Q E      +E+D + E
Sbjct: 211 RKTQTERQRETDREGERETDRRRE 234



 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 48/135 (35%), Positives = 85/135 (62%), Gaps = 3/135 (2%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRRRE-EEEREKERARDRE 288
           +EK R+R  E DRD + + E +   +RE+E+++ERE ER+R R+R+ E+ERE++  R+R+
Sbjct: 149 REKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERD 208

Query: 289 RRKRSRS-RSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS 347
           R++++++ R R + R  +R   R R+ +R R R + R R RDR+  R  +R + + + R 
Sbjct: 209 RQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERK 268

Query: 348 RDRRRSKSRDRKSYK 362
             ++  K R+ K  K
Sbjct: 269 EKKKEEKRREDKKRK 283



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 45/133 (33%), Positives = 73/133 (54%), Gaps = 12/133 (9%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDR 287
           E+ ++  R+   E +RD   +K+K+   ER+++R+R+ E        +E ER+ +R RDR
Sbjct: 158 EKDRDGQRETETERERDREREKQKERETERDRDRQRDTE--------KERERQTDRERDR 209

Query: 288 ERR---KRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR-SERKH 343
           +R+   +R R   R   R +DRR  R RD  R + R+R R R  +R++ R  +R  ERK 
Sbjct: 210 QRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKE 269

Query: 344 RSRSRDRRRSKSR 356
           + +   RR  K R
Sbjct: 270 KKKEEKRREDKKR 282



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 42/133 (31%), Positives = 68/133 (51%), Gaps = 19/133 (14%)

Query: 305 DRRCSRSR-DHKRSRSRERRRSRSRDRRR-----SRSHDRSERKHRSRSRDRRRSKSRDR 358
           DR+  R R   K  + R+R R R R+RRR     +R+ DR ++    R R+R + K R+R
Sbjct: 76  DRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRER 135

Query: 359 KSYKHRSKSRDREQDR-KSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVN 417
           +    R + R+RE+DR + KE+E++   D     + G RE ++E      +E   + E  
Sbjct: 136 E----RDRGRERERDRDREKERERQTEKD-----RDGQRETETERERDREREKQKERE-- 184

Query: 418 GTSEDIKSEGDTQ 430
            T  D   + DT+
Sbjct: 185 -TERDRDRQRDTE 196


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score =  112 bits (280), Expect = 7e-25
 Identities = 81/251 (32%), Positives = 131/251 (52%), Gaps = 26/251 (10%)

Query: 205 QSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERE 264
           +SR   H   K+     KIK   E +KEK R++  E +++   +KE+ + ++R+KERE++
Sbjct: 366 KSRSRSHSRDKRKDTREKIKEK-ERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD 424

Query: 265 REERERKRRREEEEREKERARDRERRK-RSRSRSRHSSRTSDRRCSRSRDHKRSRS---- 319
           RE+ + K R  E E+E E+ RD+E+ K + + + R   R+ +    R +D K+SR+    
Sbjct: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD-KKSRTPPRS 483

Query: 320 -----RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRS---KSRDRKSYKHRSKSRDRE 371
                R R  SR R RRRSRS  RS R  ++  R   RS   +SR++K  K R K RD  
Sbjct: 484 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD-KKREKERDHI 542

Query: 372 QDRKSKEKE---KRGSDDK-------KSSVKSGSREKQSEDTNTESKESDTKNEVNGTSE 421
            +R+ +E+    ++ S+D+       K+S     +E   E  ++ SKE D K+       
Sbjct: 543 SERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEEN 602

Query: 422 DIKSEGDTQSN 432
            I+  G+ Q N
Sbjct: 603 KIQHNGNCQLN 613



 Score =  104 bits (259), Expect = 2e-22
 Identities = 64/208 (30%), Positives = 111/208 (53%), Gaps = 16/208 (7%)

Query: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283
           +A  +EL+E +++            +E Q       E E  +    +  R     R K R
Sbjct: 269 QAAAKELEEVMKR-----------VREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317

Query: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR--RSRSHDRSER 341
           +  +   +R RS+S+H SR+ +R  SR +D +RS+S  ++RS+SR+RR  RSRSH R +R
Sbjct: 318 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377

Query: 342 KH-RSRSRDRRRSKSRDRKSYKHRSKSRDREQDR-KSKEKEK-RGSDDKKSSVKSGSREK 398
           K  R + +++ R K +DR+  + R K R++E++R K+K+++K R  D +K   K   RE+
Sbjct: 378 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER 437

Query: 399 QSEDTNTESKESDTKNEVNGTSEDIKSE 426
           + E      KE + + +     E  +S+
Sbjct: 438 EKEHEKDRDKEKEKEQDKEKEREKDRSK 465



 Score =  102 bits (253), Expect = 9e-22
 Identities = 60/230 (26%), Positives = 112/230 (48%), Gaps = 15/230 (6%)

Query: 203 DAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERE 262
           + +S   +   G +   + + K+         RKR++   R       +     R ++++
Sbjct: 294 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS------RSHNRSRSRQKD 347

Query: 263 REREERERKRRREEEEREKERARD--RERRKRSRSRSRHSSRTS--DRRCSRSRDHKRSR 318
           R R +   K+R +  ER K R+R   R++RK +R + +   R    DR   R R+ +R +
Sbjct: 348 RRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 407

Query: 319 SRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKE 378
            +ER +++ RD+ R +  ++ + K R R R++   K RD++  K + K ++RE+DR SKE
Sbjct: 408 EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR-SKE 466

Query: 379 KEKRGSDDKKSSVK----SGSREKQSEDTNTESKESDTKNEVNGTSEDIK 424
            +++   DKKS       + SR  +S       + S + +    TS+ IK
Sbjct: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIK 516



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 58/229 (25%), Positives = 107/229 (46%), Gaps = 29/229 (12%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERER---KRRREEEEREKERARDR 287
           ++K R+R++ P +     +E+++   R   R++ ++ RE+   K R +E++REKER R++
Sbjct: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK 403

Query: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS 347
           ER K  + R ++  R  +R   R +D ++ R RER +   +DR + +  ++ + K R + 
Sbjct: 404 EREKE-KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462

Query: 348 RD------------------------RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383
           R                         R RS SR+R+  + RS SR     +  K K  R 
Sbjct: 463 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522

Query: 384 SDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
              +  + K   REK+  D  +E +E +    +  +S D   +   + N
Sbjct: 523 PSPRSRNKKDKKREKE-RDHISERRERERSTSMRKSSNDRDGKEKLEKN 570



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 46/192 (23%), Positives = 98/192 (51%), Gaps = 6/192 (3%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERR 290
           K + R       R +  ++ K   ++R K RER R+ R R   R++ +  +E+ +++ER 
Sbjct: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER-RKSRSRSHSRDKRKDTREKIKEKERV 390

Query: 291 KRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDR 350
           K  + R +   R  +R   + R   + R +ER + R +D+ + R  +R +   + R +++
Sbjct: 391 KE-KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEK 449

Query: 351 RRSKSRDRKSYKHRSKSRD--REQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESK 408
            + + ++++  K RSK  D  R++D+KS+   +  +  ++S  +S SRE++   + + S+
Sbjct: 450 EKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRS--RSSSRERRRRRSRSSSR 507

Query: 409 ESDTKNEVNGTS 420
              T   +   S
Sbjct: 508 SPRTSKTIKRKS 519



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 53/160 (33%), Positives = 76/160 (47%), Gaps = 19/160 (11%)

Query: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRR--SRSHD---RSERK 342
           E  KR R      S   +    +S + K  RSR    S +R + R  S+SH    RS+ K
Sbjct: 277 EVMKRVREAQSFISAAIEPESGKSNERKGGRSR----SHTRSKSRSSSKSHSRRKRSQSK 332

Query: 343 HRSRSRDRRRSKSRDRK----SYKHRSKSRDREQDR-----KSKEKEKRGSDDKKSSVKS 393
           HRSRS +R RS+ +DR+     +K RSKSR+R + R     + K K+ R    +K  VK 
Sbjct: 333 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392

Query: 394 GSREKQSEDTNTESKESDT-KNEVNGTSEDIKSEGDTQSN 432
             REK+ E      KE +  KN+      +   E D + +
Sbjct: 393 KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD 432


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score =  112 bits (280), Expect = 7e-25
 Identities = 81/251 (32%), Positives = 131/251 (52%), Gaps = 26/251 (10%)

Query: 205 QSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERE 264
           +SR   H   K+     KIK   E +KEK R++  E +++   +KE+ + ++R+KERE++
Sbjct: 250 KSRSRSHSRDKRKDTREKIKEK-ERVKEKDREKEREREKEREKEKERGKNKDRDKEREKD 308

Query: 265 REERERKRRREEEEREKERARDRERRK-RSRSRSRHSSRTSDRRCSRSRDHKRSRS---- 319
           RE+ + K R  E E+E E+ RD+E+ K + + + R   R+ +    R +D K+SR+    
Sbjct: 309 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD-KKSRTPPRS 367

Query: 320 -----RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRS---KSRDRKSYKHRSKSRDRE 371
                R R  SR R RRRSRS  RS R  ++  R   RS   +SR++K  K R K RD  
Sbjct: 368 YNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKD-KKREKERDHI 426

Query: 372 QDRKSKEKE---KRGSDDK-------KSSVKSGSREKQSEDTNTESKESDTKNEVNGTSE 421
            +R+ +E+    ++ S+D+       K+S     +E   E  ++ SKE D K+       
Sbjct: 427 SERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEEN 486

Query: 422 DIKSEGDTQSN 432
            I+  G+ Q N
Sbjct: 487 KIQHNGNCQLN 497



 Score =  104 bits (259), Expect = 2e-22
 Identities = 64/208 (30%), Positives = 111/208 (53%), Gaps = 16/208 (7%)

Query: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKER 283
           +A  +EL+E +++            +E Q       E E  +    +  R     R K R
Sbjct: 153 QAAAKELEEVMKR-----------VREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 201

Query: 284 ARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR--RSRSHDRSER 341
           +  +   +R RS+S+H SR+ +R  SR +D +RS+S  ++RS+SR+RR  RSRSH R +R
Sbjct: 202 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 261

Query: 342 KH-RSRSRDRRRSKSRDRKSYKHRSKSRDREQDR-KSKEKEK-RGSDDKKSSVKSGSREK 398
           K  R + +++ R K +DR+  + R K R++E++R K+K+++K R  D +K   K   RE+
Sbjct: 262 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER 321

Query: 399 QSEDTNTESKESDTKNEVNGTSEDIKSE 426
           + E      KE + + +     E  +S+
Sbjct: 322 EKEHEKDRDKEKEKEQDKEKEREKDRSK 349



 Score =  102 bits (253), Expect = 9e-22
 Identities = 60/230 (26%), Positives = 112/230 (48%), Gaps = 15/230 (6%)

Query: 203 DAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERE 262
           + +S   +   G +   + + K+         RKR++   R       +     R ++++
Sbjct: 178 EPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS------RSHNRSRSRQKD 231

Query: 263 REREERERKRRREEEEREKERARD--RERRKRSRSRSRHSSRTS--DRRCSRSRDHKRSR 318
           R R +   K+R +  ER K R+R   R++RK +R + +   R    DR   R R+ +R +
Sbjct: 232 RRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK 291

Query: 319 SRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKE 378
            +ER +++ RD+ R +  ++ + K R R R++   K RD++  K + K ++RE+DR SKE
Sbjct: 292 EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDR-SKE 350

Query: 379 KEKRGSDDKKSSVK----SGSREKQSEDTNTESKESDTKNEVNGTSEDIK 424
            +++   DKKS       + SR  +S       + S + +    TS+ IK
Sbjct: 351 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIK 400



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 58/229 (25%), Positives = 107/229 (46%), Gaps = 29/229 (12%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERER---KRRREEEEREKERARDR 287
           ++K R+R++ P +     +E+++   R   R++ ++ RE+   K R +E++REKER R++
Sbjct: 228 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREK 287

Query: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS 347
           ER K  + R ++  R  +R   R +D ++ R RER +   +DR + +  ++ + K R + 
Sbjct: 288 EREKE-KERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 346

Query: 348 RD------------------------RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383
           R                         R RS SR+R+  + RS SR     +  K K  R 
Sbjct: 347 RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 406

Query: 384 SDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
              +  + K   REK+  D  +E +E +    +  +S D   +   + N
Sbjct: 407 PSPRSRNKKDKKREKE-RDHISERRERERSTSMRKSSNDRDGKEKLEKN 454



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 46/192 (23%), Positives = 98/192 (51%), Gaps = 6/192 (3%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERR 290
           K + R       R +  ++ K   ++R K RER R+ R R   R++ +  +E+ +++ER 
Sbjct: 216 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER-RKSRSRSHSRDKRKDTREKIKEKERV 274

Query: 291 KRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDR 350
           K  + R +   R  +R   + R   + R +ER + R +D+ + R  +R +   + R +++
Sbjct: 275 KE-KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEK 333

Query: 351 RRSKSRDRKSYKHRSKSRD--REQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESK 408
            + + ++++  K RSK  D  R++D+KS+   +  +  ++S  +S SRE++   + + S+
Sbjct: 334 EKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRS--RSSSRERRRRRSRSSSR 391

Query: 409 ESDTKNEVNGTS 420
              T   +   S
Sbjct: 392 SPRTSKTIKRKS 403



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 53/160 (33%), Positives = 76/160 (47%), Gaps = 19/160 (11%)

Query: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRR--SRSHD---RSERK 342
           E  KR R      S   +    +S + K  RSR    S +R + R  S+SH    RS+ K
Sbjct: 161 EVMKRVREAQSFISAAIEPESGKSNERKGGRSR----SHTRSKSRSSSKSHSRRKRSQSK 216

Query: 343 HRSRSRDRRRSKSRDRK----SYKHRSKSRDREQDR-----KSKEKEKRGSDDKKSSVKS 393
           HRSRS +R RS+ +DR+     +K RSKSR+R + R     + K K+ R    +K  VK 
Sbjct: 217 HRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 276

Query: 394 GSREKQSEDTNTESKESDT-KNEVNGTSEDIKSEGDTQSN 432
             REK+ E      KE +  KN+      +   E D + +
Sbjct: 277 KDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKD 316


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score =  110 bits (274), Expect = 3e-24
 Identities = 82/248 (33%), Positives = 122/248 (49%), Gaps = 48/248 (19%)

Query: 219 GYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREE--------REKEREREREERER 270
           G  +I   VE  + +  +R+  P R  R  + +    E        RE ERE+ER+  ER
Sbjct: 247 GAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLER 306

Query: 271 KRRREEEEREKERARDRE-RRKRSRSRSRHSSRTSDRRCSRSRDHK---RSRSRERRRSR 326
           + +  E+ER + R+ DR   R+RSRSR RH SR      SRSRD K   R R RER +  
Sbjct: 307 EAKEREKERRRSRSIDRGLERRRSRSRERHRSR------SRSRDRKGDRRDRDREREKEN 360

Query: 327 SRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS---------------YKHRSKSRDRE 371
            R RRR R +D+     R + R+R R +S++++S                +HR   RD +
Sbjct: 361 ERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSK 420

Query: 372 QDRK-----SKEKEKRGSDDKKSSVK---SGSREKQSEDTNTESKESDTKNEVNGTSEDI 423
           +++K     S+E++ R     +++ K   S S+EK S+  N ESKE   K   +G     
Sbjct: 421 KEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKN-ESKEKSNKRSRSG----- 474

Query: 424 KSEGDTQS 431
            S+G T S
Sbjct: 475 -SQGRTDS 481



 Score =  108 bits (270), Expect = 9e-24
 Identities = 71/208 (34%), Positives = 105/208 (50%), Gaps = 24/208 (11%)

Query: 232 EKLRKRTEEPDRDE-RLKKEKQEREEREKEREREREERER------KRRREEEEREKERA 284
           E+ R R+ E  R   R +  K +R +R++ERE+E E   R      K R  E E+E+ER+
Sbjct: 326 ERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS 385

Query: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
           R+R + +RSR          D+   R RD KR   +E++ SRSR R         ERKHR
Sbjct: 386 RERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSR---------ERKHR 436

Query: 345 SRSRDR---RRSKSRDR-KSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
           SRSR R   +RS+SR + KS KH+++S+++   R     + R    +KS  +  S  K+ 
Sbjct: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEK 496

Query: 401 EDTNTESKESDTKNEVNGTSEDIKSEGD 428
               + SKE   K +      D K + D
Sbjct: 497 SRKRSRSKERSHKRD----HSDSKDQSD 520



 Score =  102 bits (253), Expect = 9e-22
 Identities = 68/212 (32%), Positives = 108/212 (50%), Gaps = 12/212 (5%)

Query: 215 KQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKE--KQEREEREKEREREREERERKR 272
           ++H   ++ +    + +++ R+R +E +R  R  ++  K+   EREKERER RE  + +R
Sbjct: 334 ERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQR 393

Query: 273 RREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRER---RRSRSRD 329
            R E E +K +    +RR R   R     +   R  SR R H RSRSR R   +RSRSR 
Sbjct: 394 SRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKH-RSRSRSRNAGKRSRSRS 452

Query: 330 RRRSRSH-----DRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG- 383
           + +S  H     ++S ++ RS S+ R  S  + +K     SK + R++ R  +   KR  
Sbjct: 453 KEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDH 512

Query: 384 SDDKKSSVKSGSREKQSEDTNTESKESDTKNE 415
           SD K  S K   R  QS +  ++ K+   K+E
Sbjct: 513 SDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544



 Score = 95.9 bits (237), Expect = 6e-20
 Identities = 68/227 (29%), Positives = 108/227 (47%), Gaps = 23/227 (10%)

Query: 222 KIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRRE------ 275
           +IK    ++K+  ++  EE DR    ++ +  R      R   R  R R   RE      
Sbjct: 232 QIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRS-PRRSRSRSHHREGHGSSS 290

Query: 276 ---EEEREKERAR---DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRD 329
              E EREKER R   + + R++ R RSR   R  +RR SRSR+  RSRSR R R   + 
Sbjct: 291 FDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDR---KG 347

Query: 330 RRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSK-----EKEKRGS 384
            RR R  +R +   R R RDR   K R  +  K R +SR+R ++++S+     +K K   
Sbjct: 348 DRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDK 407

Query: 385 DDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQS 431
           DD++   +   R+ + E  ++ S+  + K+     S +      ++S
Sbjct: 408 DDRRH--RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRS 452



 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 59/174 (33%), Positives = 90/174 (51%), Gaps = 6/174 (3%)

Query: 244 DERLKKEKQEREEREKEREREREER-ERKRRREEEEREKERARDRERRKRSRSRSRHSSR 302
           D+++K   ++ ++  KE   E +   ER+R R        R   R  R RS  R  H S 
Sbjct: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289

Query: 303 TSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYK 362
           + DR   R ++  R R     + R ++RRRSRS DR   + RSRSR+R RS+SR R   K
Sbjct: 290 SFDRELEREKE--RQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR-DRK 346

Query: 363 HRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEV 416
              + RDRE++++++   +R  D  K   +   REK+ E +   SKE  ++ EV
Sbjct: 347 GDRRDRDREREKENERGRRRDRDYDKE--RGNEREKERERSRERSKEQRSRGEV 398



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 75/249 (30%), Positives = 113/249 (45%), Gaps = 24/249 (9%)

Query: 180 ESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEE-LKEKLRKRT 238
           ESF   E+ ++V    G  + +G+        L     + + +I   V++ + ++++ R 
Sbjct: 179 ESFLDDEEDLDVKAGGGCVMTIGEMLRSFLTKLEWFSTL-FPRIPVPVQKNIDQQIKTRP 237

Query: 239 EEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRS---RS 295
            +  +D    KE  E  +R  ER R R  R     R    R + R+  RE    S   R 
Sbjct: 238 RKIKKDG---KEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRE 294

Query: 296 RSRHSSRTSDRRCSRSRDHKRSRSR------ERRRSRSRDRRRSRSHDRSERKHRSRSRD 349
             R   R    R ++ R+ +R RSR      ERRRSRSR+R RSRS  R +RK   R RD
Sbjct: 295 LEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR-DRKGDRRDRD 353

Query: 350 RRRSKS------RDRKSYKHRSKSRDREQDR---KSKEKEKRGSDDKKSSVKSGSREKQS 400
           R R K       RDR   K R   R++E++R   +SKE+  RG  ++K   +     +  
Sbjct: 354 REREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHR 413

Query: 401 EDTNTESKE 409
           +D     KE
Sbjct: 414 DDKRDSKKE 422



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 36/154 (23%), Positives = 70/154 (45%), Gaps = 25/154 (16%)

Query: 203 DAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERL----KKEKQEREERE 258
           D +   DD    K+   +++ ++   E K + R R+    +  R     K  K + E +E
Sbjct: 408 DDRRHRDDKRDSKKEKKHSRSRS--RERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKE 465

Query: 259 KEREREREERERKRRREEEEREKERARDRER---RKRSRSRSRHSSRTSDRRCSRSRDHK 315
           K  +R R   + +    E+ +++E +  +E+   R RS+ RS                HK
Sbjct: 466 KSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERS----------------HK 509

Query: 316 RSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRD 349
           R  S  + +S   DRRRS+S ++  ++ + +++D
Sbjct: 510 RDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score =  109 bits (272), Expect = 6e-24
 Identities = 65/186 (34%), Positives = 100/186 (53%), Gaps = 12/186 (6%)

Query: 229 ELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE 288
           E + K  +R  E  + ER K+ K+ER ++EK+ ER++EERERK+RR    REKE     E
Sbjct: 56  ESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRR----REKENKEGEE 111

Query: 289 RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDR-RRSRSHDRSERKHRSRS 347
           + KR +   +   RTS     + R+ K  R RE R+ R R +  R +  +R ERK R R 
Sbjct: 112 KEKRKKKEKKERGRTSKE--GKERERKEERKREERKERERKKEEREKERERKERKKRERK 169

Query: 348 RDRRRSKSRDRKSYKHRSK----SRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDT 403
           +   + + R  K  K R K     ++R+++R+ KE+ +R  + KK   +   R+K  + T
Sbjct: 170 QVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQ-T 228

Query: 404 NTESKE 409
           N   KE
Sbjct: 229 NWREKE 234



 Score =  107 bits (267), Expect = 2e-23
 Identities = 57/197 (28%), Positives = 108/197 (54%), Gaps = 11/197 (5%)

Query: 224 KATVEELKEKLRKRTE-EPDRDERLKKEKQERE----EREKEREREREERERKRRREEEE 278
           ++ + E + ++  R E + +R+   KKE++ERE    EREKER+RER ++E+K  R++EE
Sbjct: 35  QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94

Query: 279 REKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR 338
           RE+++   R R K ++       R    +  R R  K  + RER+  R R+ R+ R   +
Sbjct: 95  RERKK---RRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKK 151

Query: 339 SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREK 398
            ER+   + R+R+  K R+RK    + + R  ++ ++ K++E+   + KK   +   RE+
Sbjct: 152 EERE---KERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRER 208

Query: 399 QSEDTNTESKESDTKNE 415
           + E    E ++ + + +
Sbjct: 209 KKERKKKEERKKERQKD 225



 Score =  100 bits (248), Expect = 3e-21
 Identities = 61/208 (29%), Positives = 114/208 (54%), Gaps = 13/208 (6%)

Query: 201 VGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKE 260
           + + +  ++    GK+     + K   E  K K R+R +E  R+   K++K ER++ E+E
Sbjct: 38  IREREREIETRKEGKKERESERKKERREREKRK-REREKERKRERGKKEKKGERKKEERE 96

Query: 261 REREREERERKRRREEEEREKERARDRER-RKRSRSRSRHSSRTSDRRCSRSR-DHKRSR 318
           R++ R E+E K   E+E+R+K+  ++R R  K  + R R   R  + R  R R   +R +
Sbjct: 97  RKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREK 156

Query: 319 SRERRRSRSRDRRR-------SRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDRE 371
            RER+  + R+R++        +  +R ERK R R+R + R K R+RK  + R K R ++
Sbjct: 157 ERERKERKKRERKQVGEKEEERKEKERKERKKRERNR-KERKKERERKERRERKKERKKK 215

Query: 372 QDRKSKEKEKRGSDDKKSSVKSGSREKQ 399
           ++RK + ++ R ++ ++   + G RE++
Sbjct: 216 EERKKERQKDRQTNWREK--ERGKRERK 241



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 58/177 (32%), Positives = 98/177 (55%), Gaps = 15/177 (8%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKERE-REREERERKRRREEEER------E 280
           E  KE+ R+R ++  + ER KKE++ER++R +E+E +E EE+E+++++E++ER       
Sbjct: 72  EREKERKRERGKKEKKGER-KKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEG 130

Query: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSR-----ERRRSRSRDRRRSRS 335
           KER R  ER++  R          ++   R    KR R +     E R+ + R  R+ R 
Sbjct: 131 KERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRE 190

Query: 336 HDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVK 392
            +R ERK + R R  RR + ++RK  + R K R +++    +EKE RG  ++K   K
Sbjct: 191 RNRKERK-KERERKERRERKKERKKKEERKKERQKDRQTNWREKE-RGKRERKERKK 245



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 62/217 (28%), Positives = 112/217 (51%), Gaps = 21/217 (9%)

Query: 147 GSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQS 206
           G + ++ E +  ++  ++ K+ERE  R           +E++ E     G     G+ + 
Sbjct: 33  GWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKK 92

Query: 207 RVDDHLMGKQHM----GYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREK--- 259
              +    ++      G  K K   +E KE+ R   E  +R+ + +++++ER+ERE+   
Sbjct: 93  EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152

Query: 260 EREREREERERKRR-------REEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSR 312
           ERE+ERE +ERK+R       +EEE +EKER   +ER+KR R+R +   +  +R+  R R
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEKER---KERKKRERNR-KERKKERERKERRER 208

Query: 313 DHKRSRSRERRRSRSRDRR---RSRSHDRSERKHRSR 346
             +R +  ER++ R +DR+   R +   + ERK R +
Sbjct: 209 KKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 46/170 (27%), Positives = 84/170 (49%), Gaps = 8/170 (4%)

Query: 261 REREREERERKRRREEEEREKERARDRERR---KRSRSRSRHSSRTSDRRCSRSRDHKRS 317
           RERERE   RK    E ++E+E  R +ERR   KR R R +   R   ++  +    K  
Sbjct: 39  REREREIETRK----EGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94

Query: 318 RSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSK 377
           R R++RR    ++       R +++ + R R  +  K R+RK  + R + ++RE+ ++ +
Sbjct: 95  RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154

Query: 378 EKEKRGSDDKKSSVKS-GSREKQSEDTNTESKESDTKNEVNGTSEDIKSE 426
           EKE+   + KK   K  G +E++ ++   + ++   +N      E  + E
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKE 204



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 34/117 (29%), Positives = 60/117 (51%), Gaps = 2/117 (1%)

Query: 299 HSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDR 358
           H S+   +   +S   +R R  E R+   ++R   R  +R ER+ R R R++ R + R +
Sbjct: 24  HISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGK 83

Query: 359 KSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNE 415
           K  K   K  +RE+ ++ +EKE +  ++K+   K   +E+    T+ E KE + K E
Sbjct: 84  KEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGR--TSKEGKERERKEE 138


>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
           sapiens]
          Length = 1031

 Score =  108 bits (269), Expect = 1e-23
 Identities = 67/192 (34%), Positives = 101/192 (52%), Gaps = 11/192 (5%)

Query: 243 RDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSR 302
           R+ R  +++     R   R R R   +++ +R ++ R + R RDR RR+RSRSR +  SR
Sbjct: 3   RESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDR-RRERSRSRDKRRSR 61

Query: 303 TSDR-RCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRS-------RSRDRRRSK 354
           + DR R  RSR  +R RSRERRRSRSRDRRRSRS  R  R   S       ++ +R RSK
Sbjct: 62  SRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSK 121

Query: 355 SRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKN 414
            +       + K +D++     KEK+    D  K   +   R+++ E    E ++   +N
Sbjct: 122 EKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMEN 181

Query: 415 --EVNGTSEDIK 424
             E+    E++K
Sbjct: 182 IGELKKEIEEMK 193



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 47/122 (38%), Positives = 64/122 (52%), Gaps = 2/122 (1%)

Query: 310 RSRDHKRSRSRERRRSRSRDRRRSRSHDRSER--KHRSRSRDRRRSKSRDRKSYKHRSKS 367
           R   H R RS  R RS SR R RS S  RS+R    RSRSRDR R + R R   K RS+S
Sbjct: 3   RESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSRS 62

Query: 368 RDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEG 427
           RDR++ R+S+ +E+  S +++ S     R  +S      S+ S   N+   T    +S+ 
Sbjct: 63  RDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKE 122

Query: 428 DT 429
            T
Sbjct: 123 KT 124



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 49/204 (24%), Positives = 93/204 (45%), Gaps = 18/204 (8%)

Query: 231 KEKLRKRTEEPD-RDERLKKEKQEREEREKEREREREERE---RKRRREEEEREKERARD 286
           +++ R+R+   D R  R +  K+ R  R +ER+R RE R    R RRR        R+R 
Sbjct: 45  RDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRR-------SRSRS 97

Query: 287 RERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSR----SRDRRRSRSHDRSERK 342
           R RR RS S    S +T +R  S+ +      S+E+++ +        + + + D+++ +
Sbjct: 98  RGRRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLE 157

Query: 343 HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSED 402
              R R  R  K R+ +  K      + +++ +  ++ K+ S +     +    E + E 
Sbjct: 158 EEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEG 217

Query: 403 TNTESKESDTKNEVNGTSEDIKSE 426
              E +E D    ++   E++K E
Sbjct: 218 NEMEGEELD---PLDAYMEEVKEE 238


>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
           [Homo sapiens]
          Length = 213

 Score =  107 bits (268), Expect = 2e-23
 Identities = 65/201 (32%), Positives = 108/201 (53%), Gaps = 12/201 (5%)

Query: 226 TVEELKEKLRKRTEEPDRD-ERLKKEKQEREEREKEREREREE-RERKRRREEE---ERE 280
           T  E  ++ R+R  E DR+ +R K+ K E    E++R+R+RE  RER R RE E   +RE
Sbjct: 12  TETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDRE 71

Query: 281 KERARDRER---RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHD 337
            ER R+RER   R+R   R R   R +DR     R+ ++ + RE  R R R+R + +   
Sbjct: 72  GERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMG 131

Query: 338 RSERKHRSRSRDRRRSKSRDRKSYKHR---SKSRDREQDRKSKEKEKRGSDDKKSSVKSG 394
           R  +  R   R+R R   R+R++ + R    + R+RE++RK + + KR + +++      
Sbjct: 132 RERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDM- 190

Query: 395 SREKQSEDTNTESKESDTKNE 415
            RE+Q E      ++ +++ E
Sbjct: 191 ERERQRETDRKRDRQRESERE 211



 Score =  101 bits (251), Expect = 2e-21
 Identities = 61/181 (33%), Positives = 100/181 (55%), Gaps = 5/181 (2%)

Query: 221 AKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRRE-EEER 279
           AK   T +   E+ R+R  E +R+    +E++++ +RE ER+RERE R+R R+RE E ER
Sbjct: 34  AKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERE-RDRDRQRETERER 92

Query: 280 EKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRS 339
           +KER  DR   +  R R +   R  +R   R R+ ++   RER+  R  DR R R  +R 
Sbjct: 93  DKERETDR-HTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERE 151

Query: 340 ERKHRSR-SRDRRRSKSRDRKSYKHRSK-SRDREQDRKSKEKEKRGSDDKKSSVKSGSRE 397
               R R + DR R + R+RK  + R + +++RE+    + + +R +D K+   +   RE
Sbjct: 152 RETGRERKTEDRHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQRESERE 211

Query: 398 K 398
           +
Sbjct: 212 R 212



 Score = 99.0 bits (245), Expect = 7e-21
 Identities = 51/186 (27%), Positives = 96/186 (51%), Gaps = 3/186 (1%)

Query: 245 ERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTS 304
           E + ++++ R E ++ER+R +E +   R   E +R+++R R+RE R R R R + + R  
Sbjct: 15  ETMDRQRERRRETDRERDRAKESKTEDRH-SERDRQRDRERNRE-RDRDREREKQTDREG 72

Query: 305 DRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHR 364
           +R+  R RD  R R  ER R + R+  R    DR  +K + R  +R R + R+++    R
Sbjct: 73  ERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGR 132

Query: 365 SKSRDREQDR-KSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDI 423
            +  DRE DR + ++ E+     ++   +   RE++ E      ++ +TK     T  + 
Sbjct: 133 ERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDMER 192

Query: 424 KSEGDT 429
           + + +T
Sbjct: 193 ERQRET 198



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 57/192 (29%), Positives = 99/192 (51%), Gaps = 7/192 (3%)

Query: 240 EPDRDERLKKEKQEREEREKERERERE-ERERKRRREEEEREKERARDRER-RKRSRSRS 297
           E   + R    + E  +R++ER RE + ER+R +  + E+R  ER R R+R R R R R 
Sbjct: 2   ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRD 61

Query: 298 RHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRD 357
           R   + +DR   R R+ +R R R+R   R RD+ R         + R + ++R   + RD
Sbjct: 62  REREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRD 121

Query: 358 RKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVN 417
           R+  K +   R+R+ DR++  + +R ++ ++ +     RE+++ED + E +E + K E  
Sbjct: 122 REREKQKEMGRERQTDRETDRERERQAERERET----GRERKTEDRHRE-RERERKRERE 176

Query: 418 GTSEDIKSEGDT 429
              E  + E  T
Sbjct: 177 RKRETKERERHT 188



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 34/105 (32%), Positives = 62/105 (59%), Gaps = 3/105 (2%)

Query: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKERERERE---ERERKRRREEEEREKERA 284
           ++ KE+  +R  + +R+++ +  ++ + +RE +RERER+   ERE  R R+ E+R +ER 
Sbjct: 109 QKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERE 168

Query: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRD 329
           R+R+R +  +  ++   R +D    R R+  R R R+R   R RD
Sbjct: 169 RERKRERERKRETKERERHTDMERERQRETDRKRDRQRESERERD 213



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 49/145 (33%), Positives = 72/145 (49%), Gaps = 31/145 (21%)

Query: 167 EERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQ-HMGYAKIKA 225
           +ERE  R T +  E    +E++ME                RV D    KQ  MG  +   
Sbjct: 94  KERETDRHTETDRERQKQKEREME----------------RVRDREREKQKEMGRER--- 134

Query: 226 TVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERERE-ERERKRRREEEER----E 280
             +  +E  R+R  + +R+    +E++  E+R +ERERER+ ERERKR  +E ER    E
Sbjct: 135 --QTDRETDRERERQAERERETGRERKT-EDRHRERERERKRERERKRETKERERHTDME 191

Query: 281 KERARDRERRKRSRSRSRHSSRTSD 305
           +ER R+ +R+   R R R S R  D
Sbjct: 192 RERQRETDRK---RDRQRESERERD 213


>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
           sapiens]
          Length = 434

 Score =  107 bits (268), Expect = 2e-23
 Identities = 73/206 (35%), Positives = 101/206 (49%), Gaps = 16/206 (7%)

Query: 222 KIKATVEELKEKLRKRTEEPDR----DERLKKEKQER---EEREKERERER--------E 266
           K K+  E  K + R R++E  R    D+  KK K E    +E   ++ RER        +
Sbjct: 51  KRKSDNEGRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGED 110

Query: 267 ERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSR 326
             +RK R+    R   R+R RERR RSRSR R  SR+  R   +SR   R R + R RSR
Sbjct: 111 RHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSR 170

Query: 327 SRDRR-RSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSD 385
            R RR RSRS  RS  +HR+RSR R RS+SRDRK    + +   R   R       RG +
Sbjct: 171 ERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRN 230

Query: 386 DKKSSVKSGSREKQSEDTNTESKESD 411
               + ++ +R  +      E +E +
Sbjct: 231 TAMDAQEALARRLERAKKLQEQREKE 256



 Score =  104 bits (259), Expect = 2e-22
 Identities = 64/166 (38%), Positives = 96/166 (57%), Gaps = 21/166 (12%)

Query: 235 RKRTEEPDRDERLKKEKQEREEREKE-REREREERERKRRREEEEREKERARDRERRKRS 293
           R R+ E  R    +  K     R KE R  E +++  K+ + EE  +KE + D+ R + +
Sbjct: 44  RSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLN 103

Query: 294 RSRS---RHSSRTSDRRCSRSRDHKRSRSRERR-----------RSRSRDRRRSRSHDRS 339
            S +   RH  +  +R+ SR R H RSRSRERR           RSRSR+R++SRS  R 
Sbjct: 104 SSENGEDRHKRK--ERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRE 161

Query: 340 ERKHRSRSRDRR---RSKSRDRKSYKHRSKSRDREQDRKSKEKEKR 382
            +K RSRSR+R+   RS+SR R  ++HR++SR R + R S++++KR
Sbjct: 162 RKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSR-SRDRKKR 206



 Score =  100 bits (248), Expect = 3e-21
 Identities = 66/207 (31%), Positives = 105/207 (50%), Gaps = 25/207 (12%)

Query: 219 GYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERER-------- 270
           G A  K + +  K+K +       R  +    +     RE++R+ + E R+         
Sbjct: 10  GLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKE 69

Query: 271 -----------KRRREEEEREKERARDRER-RKRSRSRSRHSSRTSDRRCSRSRDHKRSR 318
                      K+ + EE  +KE + D+ R R  S        +  +R+ SR R H RSR
Sbjct: 70  GRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSR 129

Query: 319 SRERR-RSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDR---KSYKHRSKSRDREQDR 374
           SRERR RSRSR+R++SRS  R  +K RSRSR+R++S+SR R   +  + RS+SR R + R
Sbjct: 130 SRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHR 189

Query: 375 -KSKEKEKRGSDDKKSSVKSGSREKQS 400
            +S+ + +  S D+K  ++   R  +S
Sbjct: 190 TRSRSRTRSRSRDRKKRIEKPRRFSRS 216



 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 59/204 (28%), Positives = 99/204 (48%), Gaps = 28/204 (13%)

Query: 240 EPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE-----RRKRSR 294
           + +RD    ++     +++KE+          +      R + R R R+     R+ RSR
Sbjct: 5   DTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSR 64

Query: 295 SRS----RHSSRTSDRRCSRSRDHK-------RSRSR--------ERRRSRSRDRRRSRS 335
           SRS    RH S+    +  +S +H        + R R        +R + + R   R RS
Sbjct: 65  SRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRS 124

Query: 336 HDRS---ERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVK 392
           H RS   ER+HRSRSR+R++S+SR R+  K RS+SR+R++ R S+ +E++     +S  +
Sbjct: 125 HSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSR-SRSRERKRRIRSRSRSR 183

Query: 393 SGSREKQSEDTNTESKESDTKNEV 416
           S  R +    + T S+  D K  +
Sbjct: 184 SRHRHRTRSRSRTRSRSRDRKKRI 207



 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 58/159 (36%), Positives = 86/159 (54%), Gaps = 12/159 (7%)

Query: 232 EKLRKRTEEPDRDERLKKEKQEREEREKEREREREE-----RERKRRREEE-EREKERAR 285
           E   KR E      R     + RE R + R RER++     RERK+ R    ER+K R+R
Sbjct: 109 EDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSR 168

Query: 286 DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSER---- 341
            RER++R RSRSR  SR+  R  +RSR   RSRSR+R++   + RR SRS  R+      
Sbjct: 169 SRERKRRIRSRSR--SRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPF 226

Query: 342 KHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKE 380
           + R+ + D + + +R  +  K   + R++E   K K++E
Sbjct: 227 RGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQE 265



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 24/92 (26%), Positives = 46/92 (50%), Gaps = 5/92 (5%)

Query: 345 SRSRDRRRSKSR----DRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
           S  RD+++ +S      R S  H S+SR R ++RK K   +      +S  K G R  +S
Sbjct: 17  SPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEG-RRHES 75

Query: 401 EDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
           +D +++  +S+  N+   +S+  +   ++  N
Sbjct: 76  KDKSSKKHKSEEHNDKEHSSDKGRERLNSSEN 107


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score =  104 bits (260), Expect = 1e-22
 Identities = 76/249 (30%), Positives = 126/249 (50%), Gaps = 29/249 (11%)

Query: 205 QSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREE-REKERER 263
           + R+     G+ H    K K    + K K ++R+   ++ ++L+ +  E +  + KE++R
Sbjct: 482 EKRMRSRSKGRDHEN-VKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDR 540

Query: 264 EREERER-------KRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKR 316
             + R R       K       RE+ R+RDR RR RSR+  R  SR+ +    R ++++R
Sbjct: 541 RAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRR 600

Query: 317 ---SRSRERR----RSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHR----- 364
              SRSRERR    RSRS+DRRR R   RS  +  S+SR++ + ++++ KS  HR     
Sbjct: 601 RGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKS-SHRKENSE 659

Query: 365 ------SKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNG 418
                 SKSRD      S+EK+        S +K  S++ + + +  ++KE D K   + 
Sbjct: 660 SEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKE-DEKIRSSV 718

Query: 419 TSEDIKSEG 427
             E+ KS+G
Sbjct: 719 EKENQKSKG 727



 Score =  102 bits (254), Expect = 7e-22
 Identities = 86/261 (32%), Positives = 128/261 (49%), Gaps = 44/261 (16%)

Query: 203 DAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERE 262
           + + +V DH    +     +     ++ K K++KR +   R +   KEK + +ER+ +  
Sbjct: 421 EKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSK--SKEKSKSKERDSKHN 478

Query: 263 REREERERKR---RREEEEREKERARDRERRKRSRSRSR--------------HS-SRTS 304
           R  E+R R R   R  E  +EKE+  D + + + RSRS+              HS S+  
Sbjct: 479 RNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEK 538

Query: 305 DRRC-SRSRD--------HKRSRSRERRRSRSRDRR-RSRSHD----RSERKHRSRS--- 347
           DRR  SRSR+           SR+RER RSR R RR RSR+HD    RS+  HR R    
Sbjct: 539 DRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEY 598

Query: 348 RDRRRSKSRDRKSYKHRSKSRD---REQDRKSKEKEKRGSDDK----KSSVKSGSREKQS 400
           R R RS+SR+R++   RS+S+D   R +D +S E+E+  S +K        KS  R++ S
Sbjct: 599 RRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENS 658

Query: 401 EDTNTESKESDTKNEVNGTSE 421
           E       +S   N  N + E
Sbjct: 659 ESEKRMYSKSRDHNSSNNSRE 679



 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 74/219 (33%), Positives = 106/219 (48%), Gaps = 30/219 (13%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEE-----REKERAR 285
           KEK R R +   R+  + K K     R +ER R R+   R R R  +      +E  R R
Sbjct: 536 KEKDR-RAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYR 594

Query: 286 DRERRKRSRSRSRHS------SRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRS 339
           ++E R+R RSRSR        SR+ DRR  R R   RS  RE  +SR++D+ R++    S
Sbjct: 595 EQEYRRRGRSRSRERRTPPGRSRSKDRR--RRRRDSRSSEREESQSRNKDKYRNQESKSS 652

Query: 340 ERKHRSRSRDRRRSKSRDRKSYKH-RSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREK 398
            RK  S S  R  SKSRD  S  + R K  DR+Q   SK K+    ++ KSS+     ++
Sbjct: 653 HRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDE 712

Query: 399 ------QSEDTNTESKESDTKNEVN---------GTSED 422
                 + E+  ++ +E+D  +E N         GT ED
Sbjct: 713 KIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDED 751



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 70/256 (27%), Positives = 124/256 (48%), Gaps = 56/256 (21%)

Query: 224 KATVEELKEKLRKRTEEPDR---DERLKKE----KQEREEREKEREREREERERKRRREE 276
           K+ + E+KE  R      +R   D R   E    K E+E++ K+ +   +ER+ +R  E+
Sbjct: 385 KSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEK 444

Query: 277 EEREKERARDRERRKRSRSRSRHSSRTSDRRC---------------------------- 308
           +++ K + + R + K SRS+S+  S++ +R                              
Sbjct: 445 DDKYKNKVKKRAKSK-SRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQ 503

Query: 309 --SRSRDHKRSRSRER-------------RRSRSRDRR---RSRSHDRSERKHRSRSRDR 350
             S+ +D +RSRS+E+              +S+ +DRR   RSR  D ++ KH   SR R
Sbjct: 504 SDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTR 563

Query: 351 RRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKES 410
            RS+SRDR S + RS++ DR++ R SKE  +    + +   +S SRE+++    + SK+ 
Sbjct: 564 ERSRSRDR-SRRVRSRTHDRDRSR-SKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDR 621

Query: 411 DTKNEVNGTSEDIKSE 426
             +   + +SE  +S+
Sbjct: 622 RRRRRDSRSSEREESQ 637



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 56/207 (27%), Positives = 101/207 (48%), Gaps = 21/207 (10%)

Query: 237 RTEEPDRDERLKKEKQEREEREKEREREREERER------KRRREEEEREKERARDRERR 290
           R+   DR  R +     R+E ++ +       ER          E +E ++   R +ER+
Sbjct: 346 RSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERK 405

Query: 291 KRSRSRSRHSSRTSDRRCSRSRDHKRSRSRER---RRSRSRDRRRSRSHDRSERKHRSRS 347
                    S    + +  + +DHK S S+ER   R S   D+ +++   R++ K RS+S
Sbjct: 406 ITDHRNVSESPNRKNEKEKKVKDHK-SNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKS 464

Query: 348 RDRRRSKSRDRKSYKH---RSKSRDREQDRKS-KEKEK----RGSDDKKSSVKSGSRE-- 397
           +++ +SK RD K  ++   R +SR + +D ++ KEKEK    +G D ++S  K  S++  
Sbjct: 465 KEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLE 524

Query: 398 -KQSEDTNTESKESDTKNEVNGTSEDI 423
            K +E  +++SKE D + +      DI
Sbjct: 525 SKSNEHDHSKSKEKDRRAQSRSRECDI 551



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 68/288 (23%), Positives = 125/288 (43%), Gaps = 66/288 (22%)

Query: 211 HLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERL---------------KKEKQERE 255
           H   K+    +K  A+ E   E L  + +   R E +               K +++ER+
Sbjct: 241 HKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERK 300

Query: 256 EREKERERE------------------REERERKRRREEEEREKERARDRERRKRSRS-- 295
            RE+ERERE                  R  R+ K R     R   R+R R+R +RS +  
Sbjct: 301 NRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPP 360

Query: 296 ----------RSRHSS-----RTSDRRCSRSRDHKRSRSRERRR--------SRSRDRRR 332
                     R R SS     +      +  ++++RS  R + R        S S +R+ 
Sbjct: 361 HWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKN 420

Query: 333 SRSHDRSERKHRSRSRDRRRSKSRDRK---SYKHRSKSRDREQDR---KSKEKEKRGSDD 386
            +     + K  S+ RD RR+  +D K     K R+KS+ R + +   KSKE++ + + +
Sbjct: 421 EKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRN 480

Query: 387 KKSSVKSGSREKQSEDTNTESKESDT--KNEVNGTSEDIKSEGDTQSN 432
           ++  ++S S+ +  E+   + K+SD+  K++    S++   + +++SN
Sbjct: 481 EEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSN 528



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 61/264 (23%), Positives = 106/264 (40%), Gaps = 73/264 (27%)

Query: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRR---REEE--- 277
           ++  EE  +K +K+  +  R  + +K+K+++ ++    E E E  E + +   R EE   
Sbjct: 220 ESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPP 279

Query: 278 --------EREKERARDRERRKRSRSRSRHSSRTSD------RRCSRSRDHKRSRSRERR 323
                    +   +A ++ER+ R R R R  +  +       RR   +R  ++ + R  R
Sbjct: 280 IPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPR 339

Query: 324 RSRSRDRRRSRSHDR--------------------------------------------- 338
           R R+  R RSR   R                                             
Sbjct: 340 RYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPV 399

Query: 339 --SERK---HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKS 393
              ERK   HR+ S    R   +++K   H+S S++R+  R++ EK+ +  +  K   KS
Sbjct: 400 RVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERD-IRRNSEKDDKYKNKVKKRAKS 458

Query: 394 GSREKQSEDTNTESKESDTKNEVN 417
            SR K  E   ++SKE D+K+  N
Sbjct: 459 KSRSKSKE--KSKSKERDSKHNRN 480



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 48/207 (23%), Positives = 90/207 (43%), Gaps = 30/207 (14%)

Query: 248 KKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRH-----SSR 302
           K +K++++ R+  R+ ++E+++RK+ ++    E E A + E + +S  R         +R
Sbjct: 226 KSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESE-AENLEAQPQSTVRPEEIPPIPENR 284

Query: 303 TSDRRCSRSRDHKRSRSRERRRSRSRD----------------RRRSRSHDRSERKHRSR 346
              R+     D K  ++RER R R  +                R   +   R  R++R+ 
Sbjct: 285 FLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTP 344

Query: 347 SRDRRRSKSRDRKSYKHRSKSRDREQDRK--SKEKEKRGSDDKKSSVKSGSR------EK 398
           SR R R + R  ++  H  +   R Q  +  S E+  +G   + + +K   R      E+
Sbjct: 345 SRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKER 404

Query: 399 QSEDTNTESKESDTKNEVNGTSEDIKS 425
           +  D    S+  + KNE     +D KS
Sbjct: 405 KITDHRNVSESPNRKNEKEKKVKDHKS 431



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 34/157 (21%), Positives = 64/157 (40%), Gaps = 20/157 (12%)

Query: 287 RERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSR 346
           +E +KR +S S  SS +SD   S         S     +  + ++R + H ++ RKH+  
Sbjct: 185 KEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKE 244

Query: 347 SRDRRRSKSRDRKSYKHRSKSRDRE----------------QDRKSKEKEKRGSDDKKSS 390
            + R++SK    KS    S++ + E                ++R    K    +D+K+  
Sbjct: 245 KKKRKKSK----KSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERK 300

Query: 391 VKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEG 427
            +   RE++    N++      +  V  +   IK  G
Sbjct: 301 NRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRG 337



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 32/136 (23%), Positives = 55/136 (40%), Gaps = 6/136 (4%)

Query: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340
           +E  R+ E +K   + S+  +      C       + +  E++R +S     S S D   
Sbjct: 148 QEVVREIENQKTDAA-SKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDS 206

Query: 341 RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
                 S D   S+S   +  K R K   +   +  KEK+KR     K S KS S E ++
Sbjct: 207 SSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKR-----KKSKKSASSESEA 261

Query: 401 EDTNTESKESDTKNEV 416
           E+   + + +    E+
Sbjct: 262 ENLEAQPQSTVRPEEI 277



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 24/124 (19%), Positives = 53/124 (42%), Gaps = 6/124 (4%)

Query: 235 RKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSR 294
           R+ ++  ++D   K   QE +   ++   E E+R   + R+       R +  +R +   
Sbjct: 633 REESQSRNKD---KYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPF 689

Query: 295 SRSRHSSRTSDRRCS---RSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRR 351
           S+ + SS+ ++ + S      D K   S E+   +S+ +     H+++++     S    
Sbjct: 690 SKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTD 749

Query: 352 RSKS 355
             KS
Sbjct: 750 EDKS 753



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 18/121 (14%), Positives = 50/121 (41%), Gaps = 4/121 (3%)

Query: 231 KEKLRKRTEEPDRDERLK----KEKQEREEREKEREREREERERKRRREEEEREKERARD 286
           +E+ + R ++  R++  K    KE  E E+R   + R+       R ++ +  +   ++ 
Sbjct: 633 REESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKI 692

Query: 287 RERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSR 346
           ++  + +  +S       D +   S + +  +S+ +      ++ +   H+ S      +
Sbjct: 693 KQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDK 752

Query: 347 S 347
           S
Sbjct: 753 S 753



 Score = 28.9 bits (63), Expect = 9.5
 Identities = 19/80 (23%), Positives = 33/80 (41%), Gaps = 5/80 (6%)

Query: 352 RSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESD 411
           +SK +  +  +H+S S        S   +   S D +SS  S   E  +E+ + + K+  
Sbjct: 180 KSKVKKEEKKRHKSSS-----SSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKH 234

Query: 412 TKNEVNGTSEDIKSEGDTQS 431
            KN      E  K +   +S
Sbjct: 235 RKNSRKHKKEKKKRKKSKKS 254


>gi|38146113 arginine/serine-rich coiled-coil 2 isoform b [Homo
           sapiens]
          Length = 375

 Score =  103 bits (257), Expect = 3e-22
 Identities = 67/188 (35%), Positives = 95/188 (50%), Gaps = 10/188 (5%)

Query: 229 ELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE 288
           E K+K  K+ +  + +++     + RE R    E   +  +RK R+    R   R+R RE
Sbjct: 15  ESKDKSSKKHKSEEHNDKEHSSDKGRE-RLNSSENGEDRHKRKERKSSRGRSHSRSRSRE 73

Query: 289 RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR-----RSRSHDRSERKH 343
           RR RSRSR R  SR+     SR R   RSRSRER++SRSR R      RSRS  RS  +H
Sbjct: 74  RRHRSRSRERKKSRSR----SRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRH 129

Query: 344 RSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDT 403
           R+RSR R RS+SRDRK    + +   R   R       RG +    + ++ +R  +    
Sbjct: 130 RTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKK 189

Query: 404 NTESKESD 411
             E +E +
Sbjct: 190 LQEQREKE 197



 Score =  100 bits (250), Expect = 2e-21
 Identities = 58/148 (39%), Positives = 92/148 (62%), Gaps = 10/148 (6%)

Query: 261 REREREERERKRRREEEEREKERARDRERRKRSRSRS---RHSSRTSDRRCSRSRDHKRS 317
           R  E +++  K+ + EE  +KE + D+ R + + S +   RH  +  +R+ SR R H RS
Sbjct: 12  RRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRK--ERKSSRGRSHSRS 69

Query: 318 RSRERR-RSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDR---KSYKHRSKSRDREQD 373
           RSRERR RSRSR+R++SRS  R  +K RSRSR+R++S+SR R   +  + RS+SR R + 
Sbjct: 70  RSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRH 129

Query: 374 R-KSKEKEKRGSDDKKSSVKSGSREKQS 400
           R +S+ + +  S D+K  ++   R  +S
Sbjct: 130 RTRSRSRTRSRSRDRKKRIEKPRRFSRS 157



 Score = 95.9 bits (237), Expect = 6e-20
 Identities = 65/155 (41%), Positives = 91/155 (58%), Gaps = 11/155 (7%)

Query: 233 KLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRER-RK 291
           K  +R E  D+  + K + +E  ++E   ++ RE        E+  + KER   R R   
Sbjct: 9   KQGRRHESKDKSSK-KHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHS 67

Query: 292 RSRSRSR-HSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDR 350
           RSRSR R H SR+ +R+ SRSR    SR R++ RSRSR+R++SRS  R ERK R RSR R
Sbjct: 68  RSRSRERRHRSRSRERKKSRSR----SRERKKSRSRSRERKKSRSRSR-ERKRRIRSRSR 122

Query: 351 RRSKSRDRKSYKHRSKSRDREQDRKSK-EKEKRGS 384
            RS+ R R   + RS++R R +DRK + EK +R S
Sbjct: 123 SRSRHRHRT--RSRSRTRSRSRDRKKRIEKPRRFS 155



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 60/151 (39%), Positives = 87/151 (57%), Gaps = 13/151 (8%)

Query: 234 LRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRS 293
           L++      +D+  KK K E E  +KE   ++           E+R K     R+ RK S
Sbjct: 8   LKQGRRHESKDKSSKKHKSE-EHNDKEHSSDKGRERLNSSENGEDRHK-----RKERKSS 61

Query: 294 RSRSRHSSRTSDRRC-SRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRR- 351
           R RS   SR+ +RR  SRSR+ K+SRSR    SR R + RSRS +R + + RSR R RR 
Sbjct: 62  RGRSHSRSRSRERRHRSRSRERKKSRSR----SRERKKSRSRSRERKKSRSRSRERKRRI 117

Query: 352 RSKSRDRKSYKHRSKSRDREQDRKSKEKEKR 382
           RS+SR R  ++HR++SR R + R S++++KR
Sbjct: 118 RSRSRSRSRHRHRTRSRSRTRSR-SRDRKKR 147



 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 58/159 (36%), Positives = 86/159 (54%), Gaps = 12/159 (7%)

Query: 232 EKLRKRTEEPDRDERLKKEKQEREEREKEREREREE-----RERKRRREEE-EREKERAR 285
           E   KR E      R     + RE R + R RER++     RERK+ R    ER+K R+R
Sbjct: 50  EDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSR 109

Query: 286 DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSER---- 341
            RER++R RSRSR  SR+  R  +RSR   RSRSR+R++   + RR SRS  R+      
Sbjct: 110 SRERKRRIRSRSR--SRSRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPF 167

Query: 342 KHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKE 380
           + R+ + D + + +R  +  K   + R++E   K K++E
Sbjct: 168 RGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQE 206



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 36/126 (28%), Positives = 63/126 (50%), Gaps = 9/126 (7%)

Query: 289 RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSR 348
           RR  S+ +S    ++ +      ++H   + RER  S      R +  +R   + RS SR
Sbjct: 12  RRHESKDKSSKKHKSEEHN---DKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSR 68

Query: 349 DR---RRSKSRDRKSYKHRSKSRDREQDR---KSKEKEKRGSDDKKSSVKSGSREKQSED 402
            R   RR +SR R+  K RS+SR+R++ R   + ++K +  S ++K  ++S SR +    
Sbjct: 69  SRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHR 128

Query: 403 TNTESK 408
             T S+
Sbjct: 129 HRTRSR 134



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 29/110 (26%), Positives = 50/110 (45%), Gaps = 20/110 (18%)

Query: 331 RRSRSHDRSERKHRS-----------RSRDR--------RRSKSRDRKSYKHRSKSRDRE 371
           RR  S D+S +KH+S           + R+R         R K ++RKS + RS SR R 
Sbjct: 12  RRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRS 71

Query: 372 QDRKSKEKEK-RGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTS 420
           ++R+ + + + R     +S  +  SR +  E   + S+  + K  +   S
Sbjct: 72  RERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRS 121


>gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 285

 Score =  102 bits (255), Expect = 5e-22
 Identities = 61/179 (34%), Positives = 95/179 (53%), Gaps = 21/179 (11%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKERERER-EERERKRRR---------EEEERE 280
           +E+ RKR +E  R++  + EK    +R+++RER+R  +R+RKR R          E + E
Sbjct: 66  RERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETERQEE 125

Query: 281 KERARDRERRK-RSRSRSRHSSRTSDRRCSRSRDHKRSRS---------RERRRSRSRDR 330
           +ER RDR+R K R R R R      DR     +D  R R          RER R + R+ 
Sbjct: 126 RERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRET 185

Query: 331 RRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKS 389
           RR R  +R +R+   R RDR R K R++  Y+ R   RDR+++R  + + ++  D +K+
Sbjct: 186 RRDRDRER-QREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREKDRDRQKA 243



 Score =  100 bits (250), Expect = 2e-21
 Identities = 60/203 (29%), Positives = 99/203 (48%), Gaps = 21/203 (10%)

Query: 233 KLRKRTEEPDRD----------ERLKKEKQEREEREKEREREREERERKRRREEEEREKE 282
           +L  R++  DRD            + +E++ + ERE++R+R +E    K R  E++R+++
Sbjct: 32  RLAMRSQIEDRDVLILRGSRVAPAIIRERERQRERERQRKRAKERHREKDREIEKDRDRQ 91

Query: 283 RARDRER---RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRS 339
           R RDRER   R R R R R   R  +    R  + +R R R+R + R R R+R    D+ 
Sbjct: 92  RKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKD 151

Query: 340 ERKHRSRSRDRRRS-------KSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVK 392
                 + RDR R        + R+R+  K R   RDR+++R+ +EKE R  D  +   +
Sbjct: 152 REIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQ-REKEDRERDRDRQKER 210

Query: 393 SGSREKQSEDTNTESKESDTKNE 415
              R ++ E      KE D + +
Sbjct: 211 EKDRYRERETGRDRDKERDRERQ 233



 Score = 95.5 bits (236), Expect = 8e-20
 Identities = 62/188 (32%), Positives = 97/188 (51%), Gaps = 19/188 (10%)

Query: 242 DRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRER-RKRSRSRSRHS 300
           +R+ + ++E+Q +  +E+ RE++RE  + + R+ + +RE++R RDR+R R+R   R R +
Sbjct: 59  ERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRET 118

Query: 301 SRTSDRRCSRSRDHKRSRSRERRRSRS------------RDRRRSRSHDRSER-KHRSRS 347
                    R RD KR + RER+R R             +DR R R    +ER + R R 
Sbjct: 119 ETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERE 178

Query: 348 RDRRRSKSRDRKSYKHRSKSRDREQDR-KSKEKEK---RGSDDKKSSVKSGSREKQSEDT 403
           R ++R   RDR   + R K  DRE+DR + KE+EK   R  +  +   K   RE+Q E  
Sbjct: 179 RQKQRETRRDRDRERQREKE-DRERDRDRQKEREKDRYRERETGRDRDKERDRERQREKD 237

Query: 404 NTESKESD 411
               K  D
Sbjct: 238 RDRQKAID 245



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 45/121 (37%), Positives = 69/121 (57%), Gaps = 15/121 (12%)

Query: 228 EELKEKLRKRTEEPDRDERLKKE----KQEREEREKERERERE--------ERERKRRRE 275
           +E +E+ R R  E DR+ + ++E    K    E EK+R+RERE        +RER+R+++
Sbjct: 123 QEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQ 182

Query: 276 EE-EREKERARDRERRKRSRSRSRHSSRTSDRRCSRS--RDHKRSRSRERRRSRSRDRRR 332
            E  R+++R R RE+  R R R R   R  DR   R   RD  + R RER+R + RDR++
Sbjct: 183 RETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREKDRDRQK 242

Query: 333 S 333
           +
Sbjct: 243 A 243



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 50/165 (30%), Positives = 73/165 (44%), Gaps = 30/165 (18%)

Query: 279 REKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR 338
           RE+ER R+RER+ R R++ RH  R  DR   + RD          R R RDR R R  DR
Sbjct: 58  RERERQRERERQ-RKRAKERH--REKDREIEKDRD----------RQRKRDRERQRWRDR 104

Query: 339 SERKHRSRSRDR--------RRSKSRDRKSYKHRSKSRDRE---------QDRKSKEKEK 381
             ++ R   RDR         R + RDRK  K R + R RE         +  K +++E+
Sbjct: 105 DRKRERWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDRER 164

Query: 382 RGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSE 426
              + ++   +   R+KQ E      +E   + E      D + E
Sbjct: 165 EMGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKE 209



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 30/80 (37%), Positives = 54/80 (67%), Gaps = 3/80 (3%)

Query: 215 KQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQERE-EREKERERER-EERERKR 272
           ++ MG  +     E  ++K R+   + DR+ + +KE +ER+ +R+KERE++R  ERE  R
Sbjct: 163 EREMGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGR 222

Query: 273 RREEE-EREKERARDRERRK 291
            R++E +RE++R +DR+R+K
Sbjct: 223 DRDKERDRERQREKDRDRQK 242



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 21/69 (30%), Positives = 42/69 (60%), Gaps = 13/69 (18%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQERE---EREKERE----------REREERERKRRREEE 277
           +E+ ++R    DRD   ++EK++RE   +R+KERE          R+R++   + R+ E+
Sbjct: 177 RERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREK 236

Query: 278 EREKERARD 286
           +R++++A D
Sbjct: 237 DRDRQKAID 245


>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
          Length = 484

 Score =  102 bits (254), Expect = 7e-22
 Identities = 75/231 (32%), Positives = 110/231 (47%), Gaps = 10/231 (4%)

Query: 203 DAQSRVDDHLMGKQHMGYAKIKATVE-ELKEKLRKRTEEPDRDERLKKEKQEREEREKER 261
           D  S+  +  M +     + I A +E + KE+ R+ +    R  R +     R  R + R
Sbjct: 213 DTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSR 272

Query: 262 EREREERERKRRREEEEREKERARDRERRKRSRSRSR-HSSRTSDRRCSRSRDHKRSRS- 319
            R R   + + RR  +   + R+  RER +RSRS S+    +  D+   RS+   +S S 
Sbjct: 273 SRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYST 332

Query: 320 --RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSK 377
             R R  SR R RRRSRS  RS +K RS  R   RS S  R     + K +D++++R   
Sbjct: 333 ARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHK---KEKKKDKDKERSRD 389

Query: 378 EKEKRGSDDKKSSVKSGSREKQSE-DTNTESKESDTKNEVNG-TSEDIKSE 426
           E+E+  S  KKS  K   RE++SE D + +    D   E  G  SE  K E
Sbjct: 390 ERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKE 440



 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 71/221 (32%), Positives = 105/221 (47%), Gaps = 30/221 (13%)

Query: 234 LRKRTEEPDRDERLKK--EKQEREEREKEREREREERERKRRREEEEREKERARDRERRK 291
           L+  T   + +E +K+  E Q       E +++ E+R   R R    R +  +  R RR 
Sbjct: 210 LKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRS 269

Query: 292 RSRSRSRHSSRTSDRRCSRSRDHKRSRSRER-RRSRSRDR-------------------- 330
           RSRSR R  S++  RR S+S   +RS SRER RRSRS  +                    
Sbjct: 270 RSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKS 329

Query: 331 ----RRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDD 386
               RRSRS  R  R+ RSRS  R   K R  K    RS S  R +  K K+K+K  S D
Sbjct: 330 YSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRD 389

Query: 387 KKSSVKSGSREKQSEDTNTE-SKESDTKNEVNGTSEDIKSE 426
           ++   +S S++K+S+D   +  ++S++  +V   + D   E
Sbjct: 390 ERE--RSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEE 428



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 64/246 (26%), Positives = 108/246 (43%), Gaps = 23/246 (9%)

Query: 172 LRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELK 231
           L+S TS+ E   A ++  E   +  A  I  D +     H   +      +  ++    +
Sbjct: 210 LKSDTSSKEIEEAMKRVREAQSLISA-AIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRR 268

Query: 232 EKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE--- 288
            + R R     +    ++ K  R  R   RER R  R   + R++++ +KE+ R +    
Sbjct: 269 SRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPK 328

Query: 289 -----RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH 343
                RR RS SR R   R+     S +R  K+ RS +R+ SRS   RR        +K 
Sbjct: 329 SYSTARRSRSASRERRRRRSR----SGTRSPKKPRSPKRKLSRSPSPRR-------HKKE 377

Query: 344 RSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDT 403
           + + +D+ RS+    +S   + KS+D+E+DR   E++     D K   +    E+Q  D+
Sbjct: 378 KKKDKDKERSRDERERSTSKKKKSKDKEKDR---ERKSESDKDVKQVTRDYDEEEQGYDS 434

Query: 404 NTESKE 409
             E KE
Sbjct: 435 EKEKKE 440



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 51/205 (24%), Positives = 98/205 (47%), Gaps = 37/205 (18%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREER--------------ERKRRREE 276
           K   R+R+   +R  R +   + R+++++++E++R +                R+RRR  
Sbjct: 288 KSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRR-- 345

Query: 277 EEREKERARDRERRKRSRSRSRHSSRTSDRRCSRS---RDHKRSRSRERRRSRSRDRRRS 333
                       RR RS +RS    R+  R+ SRS   R HK+ + +++ + RSRD R  
Sbjct: 346 ------------RRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERER 393

Query: 334 RSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKS 393
            +  + + K + + R+R   KS   K  K  ++  D E+     EKEK+   ++K  +++
Sbjct: 394 STSKKKKSKDKEKDRER---KSESDKDVKQVTRDYDEEEQGYDSEKEKK---EEKKPIET 447

Query: 394 GSREKQSEDTNTESKESDTKNEVNG 418
           GS + +       + +S  +++VNG
Sbjct: 448 GSPKTKECSVEKGTGDSLRESKVNG 472


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score =  101 bits (252), Expect = 1e-21
 Identities = 65/199 (32%), Positives = 103/199 (51%), Gaps = 9/199 (4%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERR 290
           + K R R++   R    KKEK     +EK R R     + + + +++  EK +  D   +
Sbjct: 229 RSKSRSRSQSRSRS---KKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGK 285

Query: 291 KRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDR 350
            +SRS SRH S++  R  S+ R  +  +     R RS+++   +S  RS  K  SRSR R
Sbjct: 286 PKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSR 345

Query: 351 RRSKSRDRKSYKHRSKSRDREQDR---KSKEKEKRGSDDKKSSVKSGSREKQSEDTNTES 407
            RSKS+D++  + RS+   R + R   KS+   KRGS  K+ S    S++K+ EDT+   
Sbjct: 346 SRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGS--KRDSKAGSSKKKKKEDTDRSQ 403

Query: 408 KESDTKNEVNGTSEDIKSE 426
             S +++ V+   E  KSE
Sbjct: 404 SRSPSRS-VSKEREHAKSE 421



 Score = 89.4 bits (220), Expect = 6e-18
 Identities = 67/212 (31%), Positives = 107/212 (50%), Gaps = 18/212 (8%)

Query: 231 KEKLRKRTEEP-DRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE- 288
           + K + + EE    ++ + K K     R K + + R   + +R  EE+     R R +E 
Sbjct: 266 RSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEK 325

Query: 289 --RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSR 346
             R+ RSRSRS+  SR+  R  S+S+D ++ R R R  SRSR R RS    +SER  +  
Sbjct: 326 SLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRS----KSERSRKRG 381

Query: 347 SRDRRRSKSRDRKSYKHRSKSRDREQDRK-SKEKEKRGSDDKKSSVKSGSREKQSEDTNT 405
           S+   ++ S  +K  +   +S+ R   R  SKE+E   S+   SS + G  E ++  TN 
Sbjct: 382 SKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSE---SSQREGRGESENAGTNQ 438

Query: 406 ESK---ESDTKNEVNGTSED---IKSEGDTQS 431
           E++    S++K++ N  SE     KS   T+S
Sbjct: 439 ETRSRSRSNSKSKPNLPSESRSRSKSASKTRS 470



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 62/209 (29%), Positives = 97/209 (46%), Gaps = 8/209 (3%)

Query: 205 QSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERE 264
           +SR   H  GK     +K K   EE  +      +   R     K K +   R +ER  E
Sbjct: 254 KSRSRSHSAGKSR---SKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVE 310

Query: 265 REERERKRRREEEEREKERARDRERRKR-SRSRSRHSSRTSDRRCSRSRDHKRSRSRERR 323
            E+R    R   +E+   ++R R R K  SRSRSR  S++ D+R  R R  + SRSR R 
Sbjct: 311 EEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRS 370

Query: 324 RSRS-RDRRRSRSHDR---SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEK 379
           RS+S R R+R    D    S +K +    DR +S+S  R   K R  ++     R+ + +
Sbjct: 371 RSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGE 430

Query: 380 EKRGSDDKKSSVKSGSREKQSEDTNTESK 408
            +    ++++  +S S  K   +  +ES+
Sbjct: 431 SENAGTNQETRSRSRSNSKSKPNLPSESR 459



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 57/154 (37%), Positives = 82/154 (53%), Gaps = 10/154 (6%)

Query: 271 KRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRS----RDHKRSRSRERRRSR 326
           ++ R  E++   R R    R RS SRSR  SR S +  SRS      H +SRSR R  SR
Sbjct: 168 RKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSR 227

Query: 327 SRDRRRSRSHDRS-ERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSD 385
           SR + RSRS  RS  +K +SRS  + +S+SR   + K RSKS+D     +++EK +   +
Sbjct: 228 SRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKD-----QAEEKIQNNDN 282

Query: 386 DKKSSVKSGSREKQSEDTNTESKESDTKNEVNGT 419
             K   +S SR K    + + S+E   + E  G+
Sbjct: 283 VGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGS 316



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 66/265 (24%), Positives = 114/265 (43%), Gaps = 49/265 (18%)

Query: 216 QHMGYAKIKATVEELK------EKLRKRTEEPDRDERLKKEKQEREEREKEREREREERE 269
           + + Y+ +K  +E+L        K+R   ++P    R    +     R + R R   +  
Sbjct: 146 EFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSR 205

Query: 270 RKRRREEEEREKERARDRE-RRKRSRSRSRHSSRT-SDRRCSRSRDHKRSRSRE----RR 323
            +    +    K R+R R   R RS+SRSR  SR+ S +  SRS   ++SRSR     + 
Sbjct: 206 SRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKS 265

Query: 324 RSRSRD---------------RRRSRSHDRSERKHRSRSRDRR----------------- 351
           RS+S+D               + RS S  +S+ K RSRS++RR                 
Sbjct: 266 RSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEK 325

Query: 352 -----RSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTE 406
                RS+SR +   + RS+SR + +D++   K  R     +S  +S S   +   +  +
Sbjct: 326 SLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRD 385

Query: 407 SKESDTKNEVNGTSEDIKSEGDTQS 431
           SK   +K +    ++  +S   ++S
Sbjct: 386 SKAGSSKKKKKEDTDRSQSRSPSRS 410



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 58/208 (27%), Positives = 91/208 (43%), Gaps = 13/208 (6%)

Query: 201 VGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKE 260
           VG  +SR       K        +  VEE K     R    ++  R  + +   +   + 
Sbjct: 283 VGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRS 342

Query: 261 REREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSR---DHKRS 317
           R R R + + KR+  +  RE+ R+R R R K  RSR R S R S    S+ +   D  RS
Sbjct: 343 RSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRS 402

Query: 318 RSRERRRSRSRDRRRSRSHDRSERKHRSRS---------RDRRRSKSRDRKSYKHRSKSR 368
           +SR   RS S++R  ++S + S+R+ R  S         R R RS S+ + +    S+SR
Sbjct: 403 QSRSPSRSVSKEREHAKS-ESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSR 461

Query: 369 DREQDRKSKEKEKRGSDDKKSSVKSGSR 396
            +   +     + R     +S  +S SR
Sbjct: 462 SKSASKTRSRSKSRSRSASRSPSRSRSR 489



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 46/230 (20%), Positives = 103/230 (44%), Gaps = 6/230 (2%)

Query: 204 AQSRVDDHLMGKQHMGYAKIKA-TVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERE 262
           ++ + ++ +    ++G  K ++ +  + K K R R++E     R+++EK+    R + +E
Sbjct: 269 SKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQE----RRVEEEKRGSVSRGRSQE 324

Query: 263 REREERERKRRREEEEREKERARDRERRKRS-RSRSRHSSRTSDRRCSRSRDHKRSRSRE 321
           +   +   + R +   R + R+R + + KR  R RSR  SR+  R  S+S   ++  S+ 
Sbjct: 325 KSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKR 384

Query: 322 RRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEK 381
             ++ S  +++    DRS+ +  SRS  + R  ++   S +      +     +      
Sbjct: 385 DSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRS 444

Query: 382 RGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQS 431
           R +   K ++ S SR +    + T S+        + +    +S   ++S
Sbjct: 445 RSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 44/124 (35%), Positives = 58/124 (46%), Gaps = 25/124 (20%)

Query: 310 RSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRD 369
           R R + RSRS  R RSRSR  R+SRS   S +   S+SR R RS SR R      SKSR 
Sbjct: 181 RRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSR------SKSRS 234

Query: 370 REQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESK-ESDTKNEVNGTSEDIKSEGD 428
           R Q R   +KEK  S                  +  +S+  S +  +    S+D ++E  
Sbjct: 235 RSQSRSRSKKEKSRSP-----------------SKEKSRSRSHSAGKSRSKSKD-QAEEK 276

Query: 429 TQSN 432
            Q+N
Sbjct: 277 IQNN 280


>gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]
          Length = 330

 Score = 97.1 bits (240), Expect = 3e-20
 Identities = 66/193 (34%), Positives = 96/193 (49%), Gaps = 5/193 (2%)

Query: 215 KQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRR 274
           K++ G A   A++ +  E      EE D DE L K K + +E E + +  +   +     
Sbjct: 132 KKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDAS--- 188

Query: 275 EEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSR 334
           EEE+  K+++  R R K   S SR SSR+S    SRSR   RSRS    +SRSR   R R
Sbjct: 189 EEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRER 248

Query: 335 SHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSG 394
           S  R   K RS SR  R S S  ++SY   S S +R + ++S+ +     D KK   +S 
Sbjct: 249 SRSRGS-KSRSSSRSHRGSSSPRKRSYSSSSSSPERNR-KRSRSRSSSSGDRKKRRTRSR 306

Query: 395 SREKQSEDTNTES 407
           S E++   ++  S
Sbjct: 307 SPERRHRSSSGSS 319



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 50/197 (25%), Positives = 89/197 (45%), Gaps = 12/197 (6%)

Query: 232 EKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRK 291
           E + +   + + DE  +K+K+ R +        +E  +++   EEE+ ++    D  + K
Sbjct: 113 EYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDE----DLSKYK 168

Query: 292 RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRR 351
                    +  S      S +   ++ +  RRSRS+ R    SH RS  +  S S  R 
Sbjct: 169 LDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRS---SHSRSSSRSSSPSSSRS 225

Query: 352 RSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESD 411
           RS+SR R S   +S+SR   ++R S+ +  +     +S   S S  K+S  +++ S E +
Sbjct: 226 RSRSRSRSSSSSQSRSRSSSRER-SRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERN 284

Query: 412 TKNEVNGTSEDIKSEGD 428
            K   + +S    S GD
Sbjct: 285 RKRSRSRSS----SSGD 297


>gi|29568103 U1 small nuclear ribonucleoprotein 70 kDa [Homo
           sapiens]
          Length = 437

 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 66/197 (33%), Positives = 99/197 (50%), Gaps = 29/197 (14%)

Query: 241 PDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHS 300
           P RD   +   +ERE RE+ RER++E RER+R R  + R + R+RD+E R+RSR RS+  
Sbjct: 229 PHRD---RDRDRERERRERSRERDKE-RERRRSRSRDRRRRSRSRDKEERRRSRERSKDK 284

Query: 301 SRTSDRRCSRSRDHKRSRSRERR---RSRSRDRRRSR------------------SHDRS 339
            R   RR SRSR+  R R RER+   R    D                         D  
Sbjct: 285 DRDRKRRSSRSRERAR-RERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGP 343

Query: 340 ERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEK-EKRGSDDKKSSVKSGSREK 398
           E K R R R+RRRS   +R+  + R + RDR+++ K  E+  +RG D+ +     G ++ 
Sbjct: 344 EEKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEARGG--GGGQDN 401

Query: 399 QSEDTNTESKESDTKNE 415
             E    +S++   ++E
Sbjct: 402 GLEGLGNDSRDMYMESE 418



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 57/196 (29%), Positives = 81/196 (41%), Gaps = 31/196 (15%)

Query: 230 LKEKLRKRTEEPDRDERLK---KEKQEREEREKEREREREERERKRRREEEEREKERARD 286
           L  + R R  E +R ER +   KE++ R  R ++R R    R+++ RR   ER K++ RD
Sbjct: 228 LPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRD 287

Query: 287 RERR-KRSRSRSRHSSRTSDRRCSRSRDHKRSRSR--------------------ERRRS 325
           R+RR  RSR R+R      +       D                              + 
Sbjct: 288 RKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKG 347

Query: 326 RSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSD 385
           R RDR R RSH    R  R R RDR R + RDR   +H+   R  E+ R        G D
Sbjct: 348 RDRDRERRRSH----RSERERRRDRDRDRDRDR---EHKRGERGSERGRDEARGGGGGQD 400

Query: 386 DKKSSVKSGSREKQSE 401
           +    + + SR+   E
Sbjct: 401 NGLEGLGNDSRDMYME 416



 Score = 68.9 bits (167), Expect = 8e-12
 Identities = 48/138 (34%), Positives = 71/138 (51%), Gaps = 23/138 (16%)

Query: 257 REKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKR 316
           R   R+      ER        R+++R R+RERR+RSR R +             R+ +R
Sbjct: 209 RHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKE------------RERRR 256

Query: 317 SRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKS 376
           SRSR+RRR RSR R         +++ R RSR+R + K RDRK    RS+ R R ++R+ 
Sbjct: 257 SRSRDRRR-RSRSR---------DKEERRRSRERSKDKDRDRKRRSSRSRERAR-RERER 305

Query: 377 KEKEKRGSDDKKSSVKSG 394
           KE+ + G  D     ++G
Sbjct: 306 KEELRGGGGDMAEPSEAG 323



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 44/112 (39%), Positives = 57/112 (50%), Gaps = 17/112 (15%)

Query: 289 RRKRSRSRSRHSSRTSDRRCSRS--------RDHKRSRSRERR-RSRSRDRRRSRSHDRS 339
           RR  +    RHS R    R            RD  R R RERR RSR RD+ R R   RS
Sbjct: 200 RRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRS 259

Query: 340 -ERKHRSRSRD-------RRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383
            +R+ RSRSRD       R RSK +DR   +  S+SR+R +  + +++E RG
Sbjct: 260 RDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRG 311



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 25/94 (26%), Positives = 42/94 (44%), Gaps = 9/94 (9%)

Query: 342 KHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDR------KSKEKEKRGSDDKKSSVKSGS 395
           +H  R    R  +        HR + RDRE++R      + KE+E+R S  +    +S S
Sbjct: 209 RHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRS 268

Query: 396 REKQSEDTNTE---SKESDTKNEVNGTSEDIKSE 426
           R+K+    + E    K+ D K   + + E  + E
Sbjct: 269 RDKEERRRSRERSKDKDRDRKRRSSRSRERARRE 302


>gi|42741682 zinc finger protein 265 isoform 2 [Homo sapiens]
          Length = 320

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 70/195 (35%), Positives = 99/195 (50%), Gaps = 11/195 (5%)

Query: 215 KQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRR 274
           K++ G A   A++ +  E      EE D DE L K K + +E E + +  +   +     
Sbjct: 132 KKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDAS--- 188

Query: 275 EEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSR 334
           EEE+  K+++    RR RS+SRS HS R+S R  S S    RSRSR R  S S+ R RS 
Sbjct: 189 EEEDSNKKKSN---RRSRSKSRSSHS-RSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSS 244

Query: 335 SHDRSE---RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSV 391
           S +RS     K RS SR  R S S  ++SY   S S +R + ++S+ +     D KK   
Sbjct: 245 SRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNR-KRSRSRSSSSGDRKKRRT 303

Query: 392 KSGSREKQSEDTNTE 406
           +S S E Q    NT+
Sbjct: 304 RSRSPESQVIGENTK 318



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 49/188 (26%), Positives = 81/188 (43%), Gaps = 5/188 (2%)

Query: 232 EKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRK 291
           E + +   + + DE  +K+K+ R +        +E  +++   EEE+ ++    D  + K
Sbjct: 113 EYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDE----DLSKYK 168

Query: 292 RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR-RSRSHDRSERKHRSRSRDR 350
                    +  S      S +   ++ +  RRSRS+ R   SRS  RS     SRSR R
Sbjct: 169 LDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSR 228

Query: 351 RRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKES 410
            RS+S      + RS SR+R + R SK +    S    SS +  S    S       K S
Sbjct: 229 SRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRS 288

Query: 411 DTKNEVNG 418
            +++  +G
Sbjct: 289 RSRSSSSG 296


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 66/223 (29%), Positives = 107/223 (47%), Gaps = 27/223 (12%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKERERE-REERERKRRR---EEEEREKERARD 286
           K + R R+  P++     + +   + R++ R R   + R+  R R   +  +R + R+  
Sbjct: 421 KARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPS 480

Query: 287 RER-------------RKRSRSRSRHSSRTSDRRCSRSRDHKRSRS----RERRRSRSRD 329
           +ER              +RSRS S+       R  S+ RDH+RSRS    R+RR+SRS +
Sbjct: 481 KERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPN 540

Query: 330 RRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEK---EKRGSDD 386
           + R RS  RS  + R   + R  SK RDR+ ++  SK R+R Q R S E+    +  S +
Sbjct: 541 KERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPN 600

Query: 387 KKSSV---KSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSE 426
           K+S     ++ S+EK    + T SKE +       + E   S+
Sbjct: 601 KQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQ 643



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 66/202 (32%), Positives = 100/202 (49%), Gaps = 25/202 (12%)

Query: 237 RTEEPDRDERLKKEKQEREERE------KEREREREERERKRRREEEEREKERARDRER- 289
           R+   +RD R     ++   R       K+R+  R     K R     R   +ARDR R 
Sbjct: 369 RSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRS 428

Query: 290 ------RKRSRSRSRHSSRTSDRRCS--RSRDHKRSRSRERRRSRSRDRRRSRSHDRSER 341
                 R  SRSRS + +R   R  S  ++RDH RSRS  + R RSR R  S+  D S+ 
Sbjct: 429 RSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQL 488

Query: 342 KHRSRSRDRRRSK--SRDRKSYKHRSKSRDREQDRK---SKEKEKRGS-----DDKKSSV 391
              S+ RD RRS+  S++R+  + RS S++R+  R    SKE+++R S     +  +S  
Sbjct: 489 GSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQS 548

Query: 392 KSGSREKQSEDTNTESKESDTK 413
           +S S E++   + + SKE D +
Sbjct: 549 RSPSEEREHRQSRSPSKERDRR 570



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 58/207 (28%), Positives = 93/207 (44%), Gaps = 13/207 (6%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKERERERE-----------ERERKRRREEEER 279
           +++ R R+    RD    +   +  +R + R   +E           ER+ +R R   + 
Sbjct: 447 RDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKE 506

Query: 280 EKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRS 339
            + R      ++R   RSR  S+   RR SRS + +R RS+ R  S  R+ R+SRS  + 
Sbjct: 507 RQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKE 566

Query: 340 ERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKK--SSVKSGSRE 397
             + R RS  + R + + R S + R  SR R  +++S     R S  +K  S  ++ S+E
Sbjct: 567 RDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKE 626

Query: 398 KQSEDTNTESKESDTKNEVNGTSEDIK 424
                + T SKESD        S D K
Sbjct: 627 GNHSQSRTSSKESDPSQSTVPRSPDWK 653



 Score = 85.5 bits (210), Expect = 9e-17
 Identities = 66/201 (32%), Positives = 96/201 (47%), Gaps = 21/201 (10%)

Query: 235 RKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSR 294
           ++R+    R    +++ +      KE  R +     K+R     R   +ARDR     SR
Sbjct: 361 KERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDR-----SR 415

Query: 295 SRSRHSSRTSDRRCS--RSRDHKRSRS----RERRRSRSRDRRRSRSHDRSERKHRSRSR 348
           SRS + +R   R  S  ++RD  RSRS    R+R RSRS ++ R  S  RS  K R RSR
Sbjct: 416 SRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSR 475

Query: 349 DRRRSKSRDRKSYKHRSKSRDREQDRK-SKEKEKRGS-------DDKKSSVKSGSREKQS 400
            R  SK RD       SK RD  + R  SKE++ R S       D ++S  +S S+E+Q 
Sbjct: 476 SRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRS--RSPSKERQR 533

Query: 401 EDTNTESKESDTKNEVNGTSE 421
             + + +KE D     + + E
Sbjct: 534 RQSRSPNKERDRSQSRSPSEE 554



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 61/196 (31%), Positives = 88/196 (44%), Gaps = 19/196 (9%)

Query: 235 RKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRK--- 291
           ++R     R     +++       K R+R R     K R     R   +ARDR R +   
Sbjct: 397 KQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPN 456

Query: 292 --RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRS--------HDRSER 341
             R  SRSR  ++  DR  SRS   +R  S+    S+ RD RRSRS          RS  
Sbjct: 457 KARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSS 516

Query: 342 KHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRK-SKEKEKRGS-----DDKKSSVKSGS 395
           K R   R R  SK R R+  +  +K RDR Q R  S+E+E R S     +  +   +S S
Sbjct: 517 KERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPS 576

Query: 396 REKQSEDTNTESKESD 411
           +E++   + + S+E D
Sbjct: 577 KERERRQSRSSSEERD 592



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 63/213 (29%), Positives = 100/213 (46%), Gaps = 22/213 (10%)

Query: 231 KEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERR 290
           KE+  +R+  P       KE+Q R+ R   +ER+   R  +   +E +R + R+ ++E  
Sbjct: 493 KERDHRRSRSPS------KERQCRQSRSSSKERDH--RRSRSPSKERQRRQSRSPNKE-- 542

Query: 291 KRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDR 350
            R RS+SR  S   + R SRS   +R R R R  S+ R+RR+SRS        RSRS ++
Sbjct: 543 -RDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNK 601

Query: 351 RRSKSRDRKSYKHRSKSRDREQDRKSKEKEKR----GSDDKKSSV-------KSGSREKQ 399
           +   SR R S K ++ SR R   ++    + R     SD  +S+V       +S +R   
Sbjct: 602 QSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSS 661

Query: 400 SEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
                T SK S        +     S+ D+Q++
Sbjct: 662 LSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQAD 694



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 60/195 (30%), Positives = 91/195 (46%), Gaps = 23/195 (11%)

Query: 249 KEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRC 308
           K K + + R   R R         +       +  +++R+ R  S  R + S R+     
Sbjct: 337 KGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPR-KESGRSQSGSP 395

Query: 309 SRSRDHKRSRS----RERRRSRS----RDRRRSR--------SHDRSERKHRSRSRDRRR 352
           ++ RDH RSRS    R+R RSRS    RDR RSR        S  RS  K R RSR R  
Sbjct: 396 NKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSP 455

Query: 353 SKSRDRKSYKHRSKSRDREQDR---KSKEKEKRGSDDKKSS---VKSGSREKQSEDTNTE 406
           +K+RD    +  +K+RDR + R   K ++  + GS  K+      +S S+E+Q   + + 
Sbjct: 456 NKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSS 515

Query: 407 SKESDTKNEVNGTSE 421
           SKE D +   + + E
Sbjct: 516 SKERDHRRSRSPSKE 530



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 55/216 (25%), Positives = 99/216 (45%), Gaps = 10/216 (4%)

Query: 214 GKQHMGYAKIKA-TVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKR 272
           G Q   ++++++ + +    + R RT +    +  +  +     + K + + R  R  + 
Sbjct: 293 GSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRS 352

Query: 273 RREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRR 332
                   KER+    R   S+ R    S +  +   RS+    ++ R+  RSRS ++ R
Sbjct: 353 HNWSRNPSKERSHSHSRSS-SKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKAR 411

Query: 333 SRSHDRSERKHRSRSRDRRRSKSRD----RKSYKHRSKSRDREQDRKSKEKEKRGSDDK- 387
            RS  RS  K R RSR R  +K+RD    R  YK R +SR R  + K+++  +  S +K 
Sbjct: 412 DRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPN-KARDHSRSRSPNKA 470

Query: 388 --KSSVKSGSREKQSEDTNTESKESDTKNEVNGTSE 421
             +S  +S S+E+      + SKE D +   + + E
Sbjct: 471 RDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKE 506



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 58/227 (25%), Positives = 93/227 (40%), Gaps = 20/227 (8%)

Query: 206 SRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERER 265
           S+  DH   +      + + +    KE+  +R+  P       KE+Q R+ R   +ER+R
Sbjct: 492 SKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPS------KERQRRQSRSPNKERDR 545

Query: 266 EERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRS 325
            +        E  + +  +++R+RR R RS S+   R   R  S  RDH RSRS  ++  
Sbjct: 546 SQSRSPSEEREHRQSRSPSKERDRR-RWRSPSKERERRQSRSSSEERDHSRSRSPNKQSG 604

Query: 326 RSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSD 385
            SR R  S        K ++ SR R  SK  +    +  SK  D      S+    R  D
Sbjct: 605 YSRPRASS--------KEKAHSRSRTPSKEGNHSQSRTSSKESD-----PSQSTVPRSPD 651

Query: 386 DKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
            K+S  ++ S  +    + T S    T      T     S+ D  ++
Sbjct: 652 WKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTS 698



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 52/157 (33%), Positives = 77/157 (49%), Gaps = 13/157 (8%)

Query: 261 REREREERERKRRREEEEREKERARDR---ERRKRSRSRSRHSSRTSDRRCSRS--RDHK 315
           RE+     E   R +   +   R+R +   + R   RSRS    RT  R  S S  R+H 
Sbjct: 253 REKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHS 312

Query: 316 RSRSRERRRSRSRDRR--RSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQD 373
           R+RSR R+   S+  R  +SRSH + + +++SR+  R RS +  R   K RS S  R   
Sbjct: 313 RARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRS-- 370

Query: 374 RKSKEKEKRGSDDKKSS---VKSGSREKQSEDTNTES 407
             SKE++ RGS   +      +SGS  KQ + + + S
Sbjct: 371 -SSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRS 406



 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 48/193 (24%), Positives = 77/193 (39%), Gaps = 15/193 (7%)

Query: 229 ELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE 288
           E+  +++   +   R  R +   Q R  R + R   ++    + R    +R   RAR R 
Sbjct: 261 EMSSRVKSYNQASTRS-RPQSHSQSRSPR-RSRSGSQKRTHSRVRSHSWKRNHSRARSRT 318

Query: 289 RR---------KRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR- 338
           R+          +SRS S+  S+   R   R R H  SR+  + RS S  R  S+  D  
Sbjct: 319 RKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHR 378

Query: 339 ---SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGS 395
              S RK   RS+    +K RD    +  +K+RDR + R   +   R      +  +  S
Sbjct: 379 GSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCS 438

Query: 396 REKQSEDTNTESK 408
           R +        S+
Sbjct: 439 RSRSPYKARDRSR 451



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 48/207 (23%), Positives = 90/207 (43%), Gaps = 22/207 (10%)

Query: 204 AQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERER 263
           + S+  DH   +      + + +    KE+ R ++  P       +E++ R+ R   +ER
Sbjct: 514 SSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSP------SEEREHRQSRSPSKER 567

Query: 264 EREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERR 323
           +R  R R   +E E R+   + +     RSRS ++ S  +  R  S+ + H RSR+  + 
Sbjct: 568 DR-RRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRSRTPSKE 626

Query: 324 RSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383
            + S+ R  S+  D S+     RS D +RS +R     ++R+ S+               
Sbjct: 627 GNHSQSRTSSKESDPSQ-STVPRSPDWKRSPTRTSSLSQNRTPSKT-------------- 671

Query: 384 SDDKKSSVKSGSREKQSEDTNTESKES 410
           S    S+  SG +    +D+  ++  S
Sbjct: 672 SSHSPSTFPSGGQTLSQDDSQADATTS 698



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 37/141 (26%), Positives = 65/141 (46%), Gaps = 2/141 (1%)

Query: 293 SRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS--RDR 350
           SR +S   +  S R  S ++   RSR +   +SRS  R RS S  R+  + RS S  R+ 
Sbjct: 252 SREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNH 311

Query: 351 RRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKES 410
            R++SR RK    +     + +     + + +    ++    + SR    E +++ S+ S
Sbjct: 312 SRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSS 371

Query: 411 DTKNEVNGTSEDIKSEGDTQS 431
             + +  G+S   K  G +QS
Sbjct: 372 SKERDHRGSSSPRKESGRSQS 392



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 48/177 (27%), Positives = 73/177 (41%), Gaps = 21/177 (11%)

Query: 271 KRRREEEEREKERARDRER---RKRSRSRSRHSSRTSDRRCSRSRD-HKRSRSRERRRSR 326
           KR        + R R + R   R  + +R+  +S+ SD RC + R  H R R+  RR SR
Sbjct: 71  KRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSR 130

Query: 327 SRDRRRSRSHDRSE-RKHRSR--SRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383
           S  R  SR+      R H +R     R R+ +  +K  + +S  R R  +R+  + + R 
Sbjct: 131 SSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRN 190

Query: 384 SDDKKSSVKSGSREKQSED-------------TNTESKESDTKNEVNGTSEDIKSEG 427
              K      GS   +S +             T   SKE  + N    +S  +KS G
Sbjct: 191 LSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEK-SDNPSPSSSRKVKSYG 246


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 92.4 bits (228), Expect = 7e-19
 Identities = 71/299 (23%), Positives = 142/299 (47%), Gaps = 32/299 (10%)

Query: 126 EEKIQVLTDKIDVLLQQIEELG----------SEGKVEEAQGMMKLVEQLKEERELLRST 175
           EEK Q   ++ D + Q+ EE             E K++E +   +   +L+EE E LR  
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ--RELQEEEEQLRKL 281

Query: 176 TSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLR 235
                    QE++ +              + R +  L  KQ     + +   E  +++ R
Sbjct: 282 ERQELRRERQEEEQQ------------QQRLRREQQLRRKQEE--ERREQQEERREQQER 327

Query: 236 KRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE---RRKR 292
           +  +E  R+++L++E++ER E++  RE+E E RE++ RRE+EE  +E+   RE   RR++
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387

Query: 293 SRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRR- 351
              R +   R    R  +    ++   RE++  R +  RR +  +R E+KH    R++R 
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447

Query: 352 RSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSS--VKSGSREKQSEDTNTESK 408
           + +  +R+ +  R +  +R +  + K++ KR  ++++    +K    E++ +    E +
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506



 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 89/386 (23%), Positives = 170/386 (44%), Gaps = 24/386 (6%)

Query: 59  EKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVE-RRIRRGHARLALSQNQQSSG 117
           E+  ++ LR++ E+  R  ++  E++  R  Q L  E + RR ++      L + QQ   
Sbjct: 344 EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR 403

Query: 118 AAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTS 177
                 + + + +    +   L ++ EE   E K E+ +   +L  + +E R+ L+    
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463

Query: 178 TIESFAAQEKQM----EVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEK 233
           T      + KQ     +  E    +L + + + R       +Q      ++   EE +E+
Sbjct: 464 TERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ------LRREQEERREQ 517

Query: 234 LRKRTEEPDR-DERLKKEKQEREEREKERE----REREER-ERKRRREEEEREKERARDR 287
             KR EE +R  +RL+ E+Q R E+E+ RE    RE E+R E++RR +  +RE+E  RD+
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577

Query: 288 ERRKRSRSRSRHSSRTSDRRC-SRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSR 346
             ++    R +   R  + R   R +  +  R  +  R   R +R     +R ++  +S 
Sbjct: 578 LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE 637

Query: 347 SRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTE 406
            ++ RR +         R +   REQ  K +E+E+R     K   +   RE++  +   E
Sbjct: 638 EQEERRQQQ------LRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691

Query: 407 SKESDTKNEVNGTSEDIKSEGDTQSN 432
                 K+ +      ++SE D + +
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQS 717



 Score = 85.9 bits (211), Expect = 7e-17
 Identities = 83/399 (20%), Positives = 170/399 (42%), Gaps = 51/399 (12%)

Query: 63  DENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPT 122
           +E   +++E+  R  ++  E++  R       E ER   +   +  L ++Q+        
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERH-EQERRKQQLKRDQEEERRERWL 489

Query: 123 GKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESF 182
              EE+ +   ++ +  L++ +E   E +++  +   +L ++L+ E++L R      E  
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549

Query: 183 AAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTE--- 239
             +E++  + +      +  + + R D  L  ++     ++K   EE  E+  KR E   
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVER 609

Query: 240 ---EPDRDERLKKEKQEREERE-----------KEREREREERER--------------- 270
              E  R++RLK+E+ E E R+           ++++  RE++ER               
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669

Query: 271 ---KRRREEEEREKERARDRERRKRSRSRSR------HSSRTSDRRCSRSRDHKRSRSRE 321
              KR  EEE RE+E A + + + R R +SR           +D R S+     R +  +
Sbjct: 670 QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729

Query: 322 RRRSRSRDRRRSRSHD----RSERKHRSRSRDRRRSK-----SRDRKSYKHRSKSRDREQ 372
           RRR    ++RR R  +      ER HR +  + +R         + KS + R +   R  
Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP 789

Query: 373 DRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESD 411
            R+ +E++ R  + ++   +    E++ E    + +E +
Sbjct: 790 LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 82/378 (21%), Positives = 175/378 (46%), Gaps = 65/378 (17%)

Query: 63   DENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPT 122
            ++ LR++ EK  R     +ER + R    L  E E+ +R    +  L + ++        
Sbjct: 1001 EQLLREEREKRRR---QEWERQY-RKKDELQQEEEQLLREEREKRRLQERERQY------ 1050

Query: 123  GKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESF 182
             + EE++Q          Q+ E+L   G+  E +   +L  Q ++E EL +     +   
Sbjct: 1051 -REEEELQ----------QEEEQL--LGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097

Query: 183  AAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQH--MGYAKIKATVEELKEKLRKRTE- 239
              + ++ E            + Q R ++ L  ++   +   + K   +EL+ + R+  E 
Sbjct: 1098 PEKRRRQE-----------RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV 1146

Query: 240  ----------EPDRDERLKKEKQEREEREK----------EREREREERERKRRREEE-- 277
                      EP++  R + E+Q REE E           E+E+ R+ERER+ R EEE  
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206

Query: 278  -EREKERARDRERR---KRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRS 333
             ++ K+R RD ++R   K      + ++   ++   + R++++ R  E  + R R  ++ 
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQD 1266

Query: 334  RSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKS 393
              H   E++ R R ++RRR + RDR  +    +  +RE+ +++K ++++  ++K+   + 
Sbjct: 1267 LQHLLGEQQERDREQERRRWQQRDR--HFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324

Query: 394  GSREKQSEDTNTESKESD 411
               +++ ++T+ + +E +
Sbjct: 1325 REEKRRRQETDRKFREEE 1342



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 45/193 (23%), Positives = 101/193 (52%), Gaps = 6/193 (3%)

Query: 229 ELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREER---ERKRRREEEEREKERAR 285
           E +E  R+R EE  + +RL++E+Q R ++E+ER  ++EER   + +R ++EE RE++  R
Sbjct: 282 ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341

Query: 286 DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRS---RERRRSRSRDRRRSRSHDRSERK 342
           ++E R+  + R        +++  R ++ +R      RE++  R +  RR +   R ++ 
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401

Query: 343 HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSED 402
            R +   R +   R+++  + +   R++E++R  ++ E+   + +    +   R+    +
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461

Query: 403 TNTESKESDTKNE 415
             TE  E + + +
Sbjct: 462 EETERHEQERRKQ 474



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 59/279 (21%), Positives = 127/279 (45%), Gaps = 26/279 (9%)

Query: 163 EQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAK 222
           E+  +E +L R     +     +EKQ +              + R D     ++   + K
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQ-------------RRERQDRVFQEEEEKEWRK 248

Query: 223 IKATVEELKEKLRKRTEEPDRDERLKKEKQ-----EREEREKEREREREERERKRRREEE 277
            +  + + +EKL++  EEP R   L++E++     ER+E  +ER+ E ++++R RR ++ 
Sbjct: 249 RETVLRKEEEKLQE--EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306

Query: 278 EREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDR-----RR 332
            R++E  R  ++ +R   + R   +   R     R+ +  R ++ RR +  +R     RR
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRR 366

Query: 333 SRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVK 392
            +  +R E++ R   + RR  + R  +  +   + R  +Q R+ ++  +     ++  ++
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426

Query: 393 SGSREKQSEDTN-TESKESDTKNEVNGTSEDIKSEGDTQ 430
               E++ E  +  E +E   K E     + +K E +T+
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465



 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 66/299 (22%), Positives = 138/299 (46%), Gaps = 12/299 (4%)

Query: 124  KNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFA 183
            K+E   Q L+ +  +  Q+  +L +E + +  Q  +   E+ ++ R   R     ++ F 
Sbjct: 776  KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ-FL 834

Query: 184  AQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRT--EEP 241
             +E+Q++  E         D      +    ++     K +  +EE + K R+ T   +P
Sbjct: 835  EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE-ERKRRRHTLYAKP 893

Query: 242  DRDERLKKEKQEREEREKERERE------REERERKRRREEEEREKERARDRERRKRSRS 295
               E+L+KE+Q  +E E+E +RE      R+E+ER+ R EE+ +++E    RE R++ R 
Sbjct: 894  ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953

Query: 296  RSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR-RSRSHDRSERKHRSRSRDRRRSK 354
            + R      D++  +  +       E+RR + R+++ R     + E +   R    +R +
Sbjct: 954  QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013

Query: 355  SRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTK 413
                + Y+ + + +  E+    +E+EKR   +++   +    E Q E+     +E +T+
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE-EEELQQEEEQLLGEERETR 1071



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 81/382 (21%), Positives = 172/382 (45%), Gaps = 39/382 (10%)

Query: 59   EKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGA 118
            EK   +   +QY K     +   E + L   +     ++ R R+      L Q ++    
Sbjct: 1009 EKRRRQEWERQYRKKDELQQ---EEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065

Query: 119  AGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTST 178
                 +  ++++    K + L Q+ E+L  E    E +   +   Q +EE EL +     
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEP--EKRRRQERERQCREEEELQQEEEQL 1123

Query: 179  IESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQH--MGYAKIKATVEELKEKLRK 236
            +     + ++ E+           + Q R ++ +  ++   +     K   +EL+ + R+
Sbjct: 1124 LREEREKRRRQEL-----------ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE 1172

Query: 237  RTEEPDRDERLKKEKQEREEREKERE-REREERERKRR----REEEER---------EKE 282
              E    +E+L +E+QE+  +E+ER+ RE EE +R++R    R+E++R         EKE
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232

Query: 283  RA-RDRE----RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHD 337
             A RD +     R+  + R    S+  DR+  +   H     +ER R + R R + R   
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292

Query: 338  RSERKHRSRSRDRRRSKSRDRKSYKHRSKSRD-REQDRKSKEKEKRGSDDKKSSVKSGSR 396
              E +   R  +++ +K RDRKS + +   R+ RE+ R+ +E +++  ++++   +   +
Sbjct: 1293 FPEEEQLERE-EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351

Query: 397  EKQSEDTNTESKESDTKNEVNG 418
              + ++ + + +E + +++  G
Sbjct: 1352 PLRRQERDRKFREEELRHQEQG 1373



 Score = 79.3 bits (194), Expect = 6e-15
 Identities = 63/284 (22%), Positives = 127/284 (44%), Gaps = 26/284 (9%)

Query: 144 EELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGD 203
           ++L  + + E  +  +KL E+ + E++  R      E    +E++++  E          
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQE---------- 523

Query: 204 AQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKE-RE 262
            + R+   L  +Q +   + +   + LK +  KR E+  R++RLK+E   +EER  +  +
Sbjct: 524 EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE---QEERRDQLLK 580

Query: 263 REREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRER 322
           RE E R+++ +RE+EER ++R + RE  +R     R   R         R  +  +S E+
Sbjct: 581 REEERRQQRLKREQEERLEQRLK-REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639

Query: 323 RRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEK- 381
              R +  RR +   R +R  R    +R   + +     + R +    E+  +++E+ K 
Sbjct: 640 EERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKS 699

Query: 382 ----------RGSDDKKSSVKSGSREKQSEDTNTESKESDTKNE 415
                       +D ++S V S  R+++ +    E +E   + E
Sbjct: 700 RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 73/335 (21%), Positives = 151/335 (45%), Gaps = 19/335 (5%)

Query: 60   KIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAA 119
            ++ ++ +R+Q E+  +FM+   +       Q L  E +R+ R     L   + QQ     
Sbjct: 1582 RLEEQKVRRQ-EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640

Query: 120  G--------PTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEEREL 171
                     P  + +E+ Q L    D   ++ E+L  EG+ ++ +   +  +  +EE++L
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700

Query: 172  LRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELK 231
             R        F  +E+Q+   E+   F      +   +   + +Q   Y KI    +   
Sbjct: 1701 RRQERE--RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER-YRKILEEEQLRP 1757

Query: 232  EKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREE---EEREKERARDRE 288
            E+  ++    +RD + ++E+Q R+ERE+++ R  +E +RK R EE   +ERE+++ R ++
Sbjct: 1758 EREEQQLRRQERDRKFREEEQLRQEREEQQLRS-QESDRKFREEEQLRQEREEQQLRPQQ 1816

Query: 289  RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSR 348
            R  + R            +  R    ++ R+ E+  ++ + RR  +   + E + R + R
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQER 1876

Query: 349  DRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383
            +R+  +   R+  K   + R   Q  + K +E +G
Sbjct: 1877 ERKLREEHIRRQQKEEQRHR---QVGEIKSQEGKG 1908



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 67/308 (21%), Positives = 139/308 (45%), Gaps = 26/308 (8%)

Query: 124 KNEEKIQVLTDKIDVLLQQIEE----LGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTI 179
           K EEK+Q    +    LQ+ EE    L  +    E Q   +  ++L+ E++L R      
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE-- 312

Query: 180 ESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTE 239
           E    QE++ E  E           + R +  L  +Q           E  +++LR+  E
Sbjct: 313 ERREQQEERREQQERRE------QQEERREQQLRREQE----------ERREQQLRREQE 356

Query: 240 EPDRDERLKKEKQEREEREKERERERE-ERERKRRREEEEREKERARDRERRKRSRSRSR 298
           E  R+++L++E QE E RE++  RE++  RE++ RRE++ R +++ R  ++ +R +   R
Sbjct: 357 EERREQQLRRE-QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415

Query: 299 HSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDR 358
                 +++  R ++ +R   +  +  R +  +R +   R   K    +   R  + R +
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET--ERHEQERRK 473

Query: 359 KSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNG 418
           +  K   +   RE+  K +E+E+R   +++       +E++ E      +E +   +   
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533

Query: 419 TSEDIKSE 426
           + + ++ E
Sbjct: 534 SEQQLRRE 541



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 73/321 (22%), Positives = 143/321 (44%), Gaps = 42/321 (13%)

Query: 122 TGKNEEKIQVLTDKIDVLLQQIEELGS------EGKVEEAQGMMKLVEQLKEERELLRST 175
           TG +EEK      K  +L  + +E         + ++EE  G  +  ++ ++EREL    
Sbjct: 93  TGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL---- 148

Query: 176 TSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQH-MGYAKIKATVEELKEKL 234
                  A  E+Q E  E     L   D Q R ++    +Q      + +A  E+L+   
Sbjct: 149 -------AEGEEQSEKQER----LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197

Query: 235 RKRTEE-PDRDERLKKE--------KQEREEREKERE----REREERERKRR----REEE 277
              TEE PD ++  ++E        ++E++++ +ER+    +E EE+E ++R    R+EE
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE 257

Query: 278 EREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRD---HKRSRSRERRRSRSRDRRRSR 334
           E+ +E    R+R  +            + R  R  +    +R R  ++ R +  + RR +
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317

Query: 335 SHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSG 394
             +R E++ R   ++ RR +   R+  + R +   REQ+ + +E++ R   +++   +  
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377

Query: 395 SREKQSEDTNTESKESDTKNE 415
            RE+Q        +E   + E
Sbjct: 378 RREQQLRREQQLRREQQLRRE 398



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 89/373 (23%), Positives = 160/373 (42%), Gaps = 26/373 (6%)

Query: 64   ENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTG 123
            E  RK  E+  +  +   ER FL   Q L  E  R+ R     L   + QQ         
Sbjct: 1427 ERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK 1486

Query: 124  KNEEKIQVLTDKIDVLLQQIEELGSEGK---VEEAQGMMKLVEQ---LKEERELLRSTTS 177
              EE+ Q+   + D   ++ E    E +   +EE Q + +   Q   L+EE++L R    
Sbjct: 1487 FLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERG 1546

Query: 178  TIE------SFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELK 231
                      F  +E+  +  E         D + R+++  + +Q     K     ++L+
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE-RKFMEDEQQLR 1605

Query: 232  --EKLRKRTEEPDR----DERLKKEKQEREEREKEREREREERERKRRREEEEREKERAR 285
              E  ++  +E DR    DE+L +E++E++   +ER+R+  E E + RR+E E++    R
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR 1665

Query: 286  DRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSR---DRRRSRSHDRSERK 342
            DR+ R+  +   +       RR  R R  +    + RR+ R R      +       ERK
Sbjct: 1666 DRKFREEEQ-LLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERK 1724

Query: 343  HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKE--KRGSDDKKSSVKSGSREKQS 400
             R   + R+ ++    +  +   K  + EQ R  +E++  +R   D+K   +   R+++ 
Sbjct: 1725 FREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER- 1783

Query: 401  EDTNTESKESDTK 413
            E+    S+ESD K
Sbjct: 1784 EEQQLRSQESDRK 1796



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 64/239 (26%), Positives = 118/239 (49%), Gaps = 40/239 (16%)

Query: 203  DAQSRVD-DHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDR----DERLKKEKQEREER 257
            D QS+ D  HL+G+Q           E  +E+ R+R ++ DR    +E+L++E+Q+  +R
Sbjct: 1260 DRQSQQDLQHLLGEQQ----------ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKR 1309

Query: 258  --------------EKEREREREERERKRRREE---EEREKERARDRERRKRSRSRS-RH 299
                          E+E +R R+E +RK R EE   +ERE++  R +ER ++ R    RH
Sbjct: 1310 RDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRH 1369

Query: 300  SSR----TSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKS 355
              +      + +  R ++ +R   +E ++ R ++R +    DR +RK R   +   R + 
Sbjct: 1370 QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR-DRKFREEEQQLSR-QE 1427

Query: 356  RDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS-EDTNTESKESDTK 413
            RDRK  +   + R +E++RK  E+E++   ++    +   +  Q  E+     +E D K
Sbjct: 1428 RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK 1486



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 74/355 (20%), Positives = 155/355 (43%), Gaps = 34/355 (9%)

Query: 59   EKIHDENLRKQYEKSSRFMKVGYERDFLRYLQS--LLAEVERRIRRGHARLALSQNQQSS 116
            E++  E   +Q  +  R  K   E   +R  +      E E+++RR   +  L Q +   
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR- 1619

Query: 117  GAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVE---QLKEERELLR 173
                   K  E  Q+L ++ +   QQ+     + K  E +  ++  E   QL+ +R+   
Sbjct: 1620 -------KFREDEQLLQEREE---QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD--- 1666

Query: 174  STTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEK 233
                    F  +E+ ++  E         D + R ++  + +Q      ++   +  +++
Sbjct: 1667 ------RKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE 1720

Query: 234  LRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDR-----E 288
            L ++  E   +E+L++E ++ + R +ER R+  E E+ R   EE++ + + RDR     E
Sbjct: 1721 LERKFRE---EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE 1777

Query: 289  RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRD-RRRSRSHDRSERKHRSRS 347
            + ++ R   +  S+ SDR+       ++ R  ++ R + RD + R         +   R 
Sbjct: 1778 QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRL 1837

Query: 348  RDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSED 402
            R  R  + R  + +  + KSR  EQ+   +E++KR  + ++   +   R +Q E+
Sbjct: 1838 RQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEE 1892



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 60/282 (21%), Positives = 128/282 (45%), Gaps = 36/282 (12%)

Query: 161  LVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQH--M 218
            L EQL++E++LL+     ++    ++++ +  E           Q R ++ L  ++   +
Sbjct: 895  LQEQLRKEQQLLQEEEEELQREEREKRRRQEQE----------RQYREEEQLQQEEEQLL 944

Query: 219  GYAKIKATVEELKEKLRKRT-----------EEPDRDERLKKEKQEREEREKERERE--- 264
               + K   +E + + RK             EEP++  R ++EK+ REE E ++E E   
Sbjct: 945  REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004

Query: 265  REERERKRRRE--------EEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKR 316
            REERE++RR+E        +E +++E    RE R++ R + R      +    +  +   
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064

Query: 317  SRSRERRRSRSRDR--RRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDR 374
               RE RR +  +R  R+     + E +      ++RR + R+R+  +     ++ EQ  
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLL 1124

Query: 375  KSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEV 416
            + + +++R  + ++   +    +++ E    E  E   + E+
Sbjct: 1125 REEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL 1166



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 83/377 (22%), Positives = 159/377 (42%), Gaps = 32/377 (8%)

Query: 59   EKIH-DENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSG 117
            +++H  E  RK  E+  +  +   +R F R  +    E ER+      +L   Q Q+   
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKF-REQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534

Query: 118  AAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVE-----EAQGMMKLVEQLKEERELL 172
                  + +E+ Q      D   ++ E+L  E + +     E     +L EQ    +E  
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE 1594

Query: 173  RSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQ-----HMGYAKIKATV 227
            R      +    QE Q ++ +         D + R D+ L+ ++     H      K   
Sbjct: 1595 RKFMEDEQQLRRQEGQQQLRQE-------RDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647

Query: 228  EE--LKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEE---REKE 282
            EE  L+ + R++    DRD + ++E+Q  +E E+++ R R+ER+RK R EE++   +E+E
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR-RQERDRKFREEEQQLRRQERE 1706

Query: 283  RARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERK 342
            R   +E ++  R       R  ++    +   +  R    R+    ++ R    +R E++
Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRP---EREEQQ 1763

Query: 343  HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKE----KRGSDDKKSSVKSGSREK 398
             R + RDR+  +    +  +   + R +E DRK +E+E    +R     +   + G    
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRW 1823

Query: 399  QSEDTNTESKESDTKNE 415
            + E    E +E   + E
Sbjct: 1824 EEEQLQLEEQEQRLRQE 1840



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 87/382 (22%), Positives = 166/382 (43%), Gaps = 30/382 (7%)

Query: 67   RKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNE 126
            RK  E+  +  +   +R FL+  Q L     RR  RG  R      +          + E
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQL-----RRQERGQQRRQDRDRKFREEEQLRQEREE 1569

Query: 127  EKI--QVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVE---QLKEEREL-LRSTTSTIE 180
            +++  Q    K  +  Q++     E K  E +  ++  E   QL++ER+   R     ++
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQ 1629

Query: 181  SFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE 240
                +E+Q+   E    FL   + Q R  +     +H    K +   + L+E   ++   
Sbjct: 1630 E--REEQQLHRQERDRKFL-EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR 1686

Query: 241  PDRDERLKKEKQE--REEREK-----EREREREERERKRRREE---EEREKERARDRER- 289
             +RD + ++E+Q+  R+ERE+     E++  R+E ERK R EE   +E E+E+ R +ER 
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY 1746

Query: 290  RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR----SERKHRS 345
            RK          R   +   + RD K     + R+ R   + RS+  DR     E+  + 
Sbjct: 1747 RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQE 1806

Query: 346  RSRDRRRSKSRDRK-SYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTN 404
            R   + R + RD K  ++      + ++ R  +E++++   +++ + +  SR ++ E   
Sbjct: 1807 REEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQ 1866

Query: 405  TESKESDTKNEVNGTSEDIKSE 426
             E ++   + E     E I+ +
Sbjct: 1867 EEEQKRRQERERKLREEHIRRQ 1888



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 82/385 (21%), Positives = 169/385 (43%), Gaps = 30/385 (7%)

Query: 59   EKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGA 118
            ++  DE+ R   +      K    RD   Y +    E  R++     R   SQ       
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271

Query: 119  AGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQ---LKEERELLRST 175
                 ++ E+ +    + D    + E+L  E + E  +   K  E+   L+EERE  R  
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331

Query: 176  TSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEE------ 229
              T   F  +E+ ++  E         D + R ++    +Q   + + +  +        
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391

Query: 230  -LKEKLRKRTEE------PDRDERLKKEKQEREEREKERE-REREERERKRRREEEEREK 281
             LKE+ + R +E       DRD + ++E+Q+   +E++R+ RE E++ R++ RE +  E+
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451

Query: 282  ERARDRERRKRSRSRSRHSSRTSDRRCSR-SRDHKRSRSRERRRSRSRDRR------RSR 334
            E+   +ER ++ R   +      +++  R  RD K     ++ R + RDR+      RS+
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ 1511

Query: 335  SHDR----SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKE--KRGSDDKK 388
              +R     E++   + R R+  +   +   + R + R +++DRK +E+E  ++  ++++
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571

Query: 389  SSVKSGSREKQSEDTNTESKESDTK 413
             S +   R+ + E+     +E + K
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERK 1596



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 90/403 (22%), Positives = 168/403 (41%), Gaps = 62/403 (15%)

Query: 67  RKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNE 126
           R+Q E+  + +K   ER   R  +     +E+R++R      L Q ++           E
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE-RLEQEERREQRLKREEPEE 627

Query: 127 EKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRS-TTSTIESFAAQ 185
           E+ Q L    +   ++ ++L  E +    Q + +  E+ + E+ L R       E   A+
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687

Query: 186 EKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATV-----EELKEKLRKRTEE 240
           E+Q +  E   +   +   Q +++     +Q   Y++ +        +E +EK R+R  E
Sbjct: 688 EEQEQARERIKSR--IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745

Query: 241 PD--RDERLKKEKQEREER-----------EKERERER--------EERERKRRREE--- 276
                +ER  +++QE E+R           + ER R+R        E+RER+ R EE   
Sbjct: 746 LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ 805

Query: 277 -------EEREKERARDRERRKRSR-----------SRSRHSSRTSDRRCSRSRDHKRSR 318
                  EE EKE+ R R+RR+R +            R   + +  +       D +R R
Sbjct: 806 REQRFLPEEEEKEQRR-RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864

Query: 319 SRERRRSR--------SRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDR 370
           S+E+RR +         R RRR   + +   + + R   +   +  +    + R K R +
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924

Query: 371 EQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTK 413
           EQ+R+ +E+E+   ++++  +    REK+           D K
Sbjct: 925 EQERQYREEEQLQQEEEQ--LLREEREKRRRQERERQYRKDKK 965



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 61/277 (22%), Positives = 123/277 (44%), Gaps = 20/277 (7%)

Query: 153  EEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHL 212
            EE Q   +  + L+EERE  R      E    ++K+++  E      ++G+   +     
Sbjct: 932  EEEQLQQEEEQLLREEREKRRRQER--ERQYRKDKKLQQKEE----QLLGEEPEKRRRQE 985

Query: 213  MGKQHMGYAKIKATVEEL--KEKLRKRTEEPDRDERLKKEKQE------REEREKER--E 262
              K++    +++   E+L  +E+ ++R +E +R  R K E Q+      REEREK R  E
Sbjct: 986  REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE 1045

Query: 263  REREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRER 322
            RER+ RE +  ++EEE+     R+  RR+    + R             R+    R R+ 
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105

Query: 323  RRSRSRDRRRSRSHD----RSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKE 378
            R  + R+    +  +    R ER+ R R    R+ +  +    +     R+  + R+ +E
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE 1165

Query: 379  KEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNE 415
             E++  ++++   +     ++ ++   + +E   + E
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 65/305 (21%), Positives = 137/305 (44%), Gaps = 21/305 (6%)

Query: 124  KNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFA 183
            +  E+ Q L ++ D L +  E   S+ +  + +   +L E+ K  R  L +  +  E   
Sbjct: 841  QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900

Query: 184  AQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEEL--KEKLRKRTEEP 241
             +++ ++  E      +  + + +       +Q+    +++   E+L  +E+ ++R +E 
Sbjct: 901  KEQQLLQEEEE----ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956

Query: 242  DRDERLKKEKQEREER------EKER--EREREERERKRRREEEEREKERARDRERRKRS 293
            +R  R  K+ Q++EE+      EK R  ERE++ RE     EE ++E+E+    ER KR 
Sbjct: 957  ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE----EEELQQEEEQLLREEREKRR 1012

Query: 294  RSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDR--RRSRSHDRSERKHRSRSRDRR 351
            R       R  D    +  +      RE+RR + R+R  R      + E +     R+ R
Sbjct: 1013 RQEWERQYRKKD-ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071

Query: 352  RSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESD 411
            R +  +R+  K     ++ EQ  + + +++R  + ++   +    +++ E    E +E  
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131

Query: 412  TKNEV 416
             + E+
Sbjct: 1132 RRQEL 1136



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 80/350 (22%), Positives = 138/350 (39%), Gaps = 46/350 (13%)

Query: 86   LRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTD----------- 134
            LR  Q LL E E  ++R        Q Q+         + EE+ Q+L +           
Sbjct: 899  LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE-QLLREEREKRRRQERE 957

Query: 135  ---KIDVLLQQIEE--LGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQM 189
               + D  LQQ EE  LG E +    Q   K   + +EE EL +     +     + ++ 
Sbjct: 958  RQYRKDKKLQQKEEQLLGEEPEKRRRQEREK---KYREEEELQQEEEQLLREEREKRRRQ 1014

Query: 190  EVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKK 249
            E            + Q R  D L  ++          + E +EK  +R +E +R  R ++
Sbjct: 1015 E-----------WERQYRKKDELQQEEEQ-------LLREEREK--RRLQERERQYREEE 1054

Query: 250  EKQEREER--EKEREREREERERKRRREEEE--REKERARDRERRKRSRSRSRHSSRTSD 305
            E Q+ EE+   +ERE  R +   ++ R+EEE  +E+E+    E  KR R       R  +
Sbjct: 1055 ELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE 1114

Query: 306  RRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRS 365
                      R    +RRR     + R     + E +   R    +R +    + Y+   
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE 1174

Query: 366  KSRDREQDRKSKEKEKRGSDDKKS--SVKSGSREKQSEDTNTESKESDTK 413
            + +  E+    +E+EKR  + ++     +   R+K+ +    E + SD K
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 85/393 (21%), Positives = 175/393 (44%), Gaps = 47/393 (11%)

Query: 60  KIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIR---RGHARLALSQNQQSS 116
           K+ +E  R+Q E+  R  ++  E++  R  +    E E R++   R   +L   Q ++  
Sbjct: 490 KLEEEERREQQER--REQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547

Query: 117 GAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEG--KVEEAQGMMKLVEQLKE--ERELL 172
                  K EE+ ++  ++ +  L++ +E   +   K EE +   +L  + +E  E+ L 
Sbjct: 548 QLL----KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603

Query: 173 RSTTSTIESFAAQEKQM---EVCEVCGAFLIVGDAQS--RVDDHLMGKQHMGYAKIKATV 227
           R     +E    +E+++   E  E     L+  + Q   R       +Q     ++K   
Sbjct: 604 REEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE 663

Query: 228 EE--LKEKLRKRTEEPDRDERLKKEKQER-EEREKER--------EREREERERK----- 271
           EE  L+++L++  EE  R++ L +E+QE+  ER K R        E E + R+ K     
Sbjct: 664 EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723

Query: 272 -----RRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSR 326
                +RR +E+ EK R R+ E + +   R+    +  ++R    RD       E +  R
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR----RDFTWQWQAEEKSER 779

Query: 327 SRDRRRSRSHDRSERKHRSRSRDRRRSKSR----DRKSYKHRSKSRDREQDRKSKEKEKR 382
            R R  +R   R +R+ + R+ +R++ + R    + +  + R + R+RE++ +  E+E++
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839

Query: 383 GSDDKKSSVKSGSREKQSEDTNTESKESDTKNE 415
               +++       +   ED      +   +++
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 74/364 (20%), Positives = 158/364 (43%), Gaps = 32/364 (8%)

Query: 59  EKIHDENLRKQYEKSSRFMKVGYERDFLRYL-----QSLLAEVERRIRRGHARLALSQNQ 113
           E+  ++ L++Q E+     ++  E+   R       Q L  E E+R+ +      L + Q
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ 571

Query: 114 QSSGAAGPTGKNEEKIQVLTDKIDVLLQQI---EELGSEGKVEEAQGMMKLVEQLKEERE 170
           +         + E + Q L  + +  L+Q    EE+    + E  +  +K  E  +E R+
Sbjct: 572 EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631

Query: 171 LLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEEL 230
            L  +    E    Q+ + E  E     L   + + R++  L  ++H    + +   EE 
Sbjct: 632 QLLKSEEQ-EERRQQQLRREQQERREQRLKREEEEERLEQRLK-REHEEERREQELAEEE 689

Query: 231 KEKLRKRTEE--PDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRE 288
           +E+ R+R +   P    +L+ E   R+ +   R R++E + R++ +EE+ R +E     +
Sbjct: 690 QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ 749

Query: 289 RRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRS----RSRDRRRSRSHDRSERKHR 344
             +R+  + +   +  D       + K  R R+R  +    R +  R+ R+ +R +R+ R
Sbjct: 750 EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQR 809

Query: 345 ----SRSRDRRRSKSRDRK------------SYKHRSKSRDREQDRKSKEKEKRGSDDKK 388
                  +++RR + R+R+              + R++    E+D   +++E+R S +++
Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869

Query: 389 SSVK 392
              K
Sbjct: 870 RDQK 873



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 77/304 (25%), Positives = 140/304 (46%), Gaps = 22/304 (7%)

Query: 95   EVERRIRRGHA--RLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKV 152
            E +RR R+     +L   + ++         K  E+ Q+L ++ +  L++ +E   + + 
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR-QERDRKFRE 1364

Query: 153  EEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHL 212
            EE +   +  + L+EE+ L R        F  +E+Q+   E         D + R ++  
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERE--RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ 1422

Query: 213  MGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKE---RERE----- 264
            + +Q       K   EE + + ++R  +   +E+  ++++ R+ RE+E   +ERE     
Sbjct: 1423 LSRQERDR---KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479

Query: 265  REERERKRRREEEE-REKERARD-RERRKRSRSRSRHSSRTSDR--RCSRSRDHKRSRSR 320
            R+ER+RK   EE++ R +ER R  RE+  RS+   R       +  R  R R   +   +
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQ 1539

Query: 321  ERRRSRSRDRR--RSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKE 378
             RR+ R + RR  R R     E+  + R   +   + RDRK      K R +EQ+RK  E
Sbjct: 1540 LRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFME 1599

Query: 379  KEKR 382
             E++
Sbjct: 1600 DEQQ 1603



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 65/307 (21%), Positives = 127/307 (41%), Gaps = 46/307 (14%)

Query: 138  VLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGA 197
            +L ++ EEL  E +  E +   +   Q +EE +L +     +     + ++ E       
Sbjct: 905  LLQEEEEELQREER--EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE------- 955

Query: 198  FLIVGDAQSRVDDHLMGKQH--MGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQERE 255
                 + Q R D  L  K+   +G    K   +E ++K R+  E    +E+L +E++E+ 
Sbjct: 956  ----RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011

Query: 256  EREKEREREREERERKRRREE------EEREKERARDRERRKRSRSRSRH-------SSR 302
             R+   E ER+ R++   ++E      EEREK R ++RER+ R     +          R
Sbjct: 1012 RRQ---EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068

Query: 303  TSDRRCSRSRDHKRSR--------------SRERRRSRSRDRRRSRSHDRSERKHRSRSR 348
             + RR    R +++                 + RR+ R R  R      + E +     R
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREER 1128

Query: 349  DRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESK 408
            ++RR +  +R+ Y+   + +  E+    +E EKR   + +   +     +Q E+     +
Sbjct: 1129 EKRRRQELERQ-YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187

Query: 409  ESDTKNE 415
            +   + E
Sbjct: 1188 QEKRRQE 1194



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 84/387 (21%), Positives = 161/387 (41%), Gaps = 51/387 (13%)

Query: 57   PCEKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSS 116
            P E+   + L+ + ++  R  ++  E+   R  +    E E R+ +   R    + ++  
Sbjct: 625  PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684

Query: 117  GAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKV----EEAQGMMKLVEQLKEERELL 172
             A     +  E+I+    K    L+  E    + KV     + +G  +  EQ +E+R   
Sbjct: 685  LAEEEQEQARERIKSRIPKWQWQLES-EADARQSKVYSRPRKQEGQRRRQEQ-EEKRRRR 742

Query: 173  RSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKE 232
             S     E   A  +Q E  E    F     A+ + +    G+Q +     +  + E +E
Sbjct: 743  ESELQWQEEERAHRQQQEE-EQRRDFTWQWQAEEKSE---RGRQRLS---ARPPLREQRE 795

Query: 233  KLRKRTEEPDRDERLKKEKQERE-------EREK-----EREREREERERKRRREEEE-- 278
            +  +  E   R++R   E++E+E       EREK     E E + + RER ++ +EEE  
Sbjct: 796  RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855

Query: 279  --REKERARDRERRK---------RSRSRSRHS----------SRTSDRRCSRSRDHKRS 317
               ++ER R +E+R+           R R RH+           R   +      +  + 
Sbjct: 856  LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915

Query: 318  RSRERRRSRSRDR--RRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRK 375
              RE+RR + ++R  R      + E +     R++RR + R+R+ Y+   K + +E+   
Sbjct: 916  EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ-YRKDKKLQQKEEQLL 974

Query: 376  SKEKEKRGSDDKKSSVKSGSREKQSED 402
             +E EKR   +++   +     +Q E+
Sbjct: 975  GEEPEKRRRQEREKKYREEEELQQEEE 1001



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 76/377 (20%), Positives = 160/377 (42%), Gaps = 27/377 (7%)

Query: 66   LRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKN 125
            LR++ E+  R  +   +R F    Q L    E+ +RR        + +      G     
Sbjct: 1321 LREEREEKRRRQET--DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE 1378

Query: 126  EEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQ 185
            EE+     ++    L++ ++L  + +  E Q       + +EE + L S       F  +
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQER--EQQLRQDRDRKFREEEQQL-SRQERDRKFREE 1435

Query: 186  EKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDE 245
            E+Q+   E    FL         +  L  ++H  + + +  ++E +E+   R E   RD 
Sbjct: 1436 EQQVRRQERERKFL-------EEEQQLRQERHRKFREEEQLLQEREEQQLHRQE---RDR 1485

Query: 246  RLKKEKQE--REERE-KEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSR 302
            +  +E+Q+  R+ER+ K RE+E   +E +R+  EEE++  R + + +  +   + R   R
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER 1545

Query: 303  TSDRRCSRSRDHKRSRS--RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS 360
               RR  R R  +      +ER   +   + R R     E+K R + ++R+  +   +  
Sbjct: 1546 GQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLR 1605

Query: 361  YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVN--- 417
             +   +   +E+DRK +E E+   + ++  +    R+++  +   + +  + + ++    
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR 1665

Query: 418  ----GTSEDIKSEGDTQ 430
                   E +  EG+ Q
Sbjct: 1666 DRKFREEEQLLQEGEEQ 1682



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 51/204 (25%), Positives = 91/204 (44%), Gaps = 23/204 (11%)

Query: 233  KLRKRTEEPDRDERLKKEKQEREEREKERER--------------EREE-RERKRRREEE 277
            +LR R  + D  + L  E+QER+ RE+ER R              EREE +E KRR  + 
Sbjct: 1257 QLRDRQSQQDL-QHLLGEQQERD-REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314

Query: 278  EREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRD---HKRSRSRERRRSRSRDRRRSR 334
            + EK+  R+    KR R  +    R  ++      +    ++ R R+ R    R + + R
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR 1374

Query: 335  SHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEK---RGSDDKKSSV 391
                 E++ R + R+R+  K   +   + R +   +++DRK +E+E+   R   D+K   
Sbjct: 1375 KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434

Query: 392  KSGSREKQSEDTNTESKESDTKNE 415
            +     +Q  +     +E   + E
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQE 1458



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 46/213 (21%), Positives = 97/213 (45%), Gaps = 21/213 (9%)

Query: 235 RKRTEEPDRDERLKKEKQERE------EREKEREREREERERKRRREEEEREKERARDRE 288
           R R  E +  +R ++++QE+E      E + E++   E+R+R+RR EE  R+++  ++RE
Sbjct: 125 RDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQERE 184

Query: 289 RRKRSRS-----RSRHSSRTSDRRCSRSRD--HKRSRSRERRRSRSRDRRRSRSHDRSER 341
            R+         +   +    D    R R+    R + RE ++ + R+R+     +  E+
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEK 244

Query: 342 KHRSRSRDRRR--SKSRDRKSYKHRSKSRDREQDRK------SKEKEKRGSDDKKSSVKS 393
           + R R    R+   K ++ +  + R    + EQ RK       +E+++     ++   + 
Sbjct: 245 EWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ 304

Query: 394 GSREKQSEDTNTESKESDTKNEVNGTSEDIKSE 426
             R KQ E+   + +E   + E     E+ + +
Sbjct: 305 QLRRKQEEERREQQEERREQQERREQQEERREQ 337



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 51/197 (25%), Positives = 92/197 (46%), Gaps = 8/197 (4%)

Query: 220 YAKIKATVEELKEKLRKRTEEPDRDERLKKEKQER-EEREKEREREREERERKRRREEEE 278
           YA  +AT  + +++ R   +E    +R ++E Q R E R+++ E E  +R R++R+E+E 
Sbjct: 87  YALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER 146

Query: 279 REKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDR 338
              E     E+++R   R R   +  D    R R  +  + RE RR+     +  + H+ 
Sbjct: 147 ELAEGEEQSEKQERLEQRDR---QRRDEELWRQR--QEWQEREERRAEEEQLQSCKGHET 201

Query: 339 SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREK 398
            E     + R R   + R RK  + + + R   QDR  +E+E++    K+ +V     EK
Sbjct: 202 EEFPDEEQLRRRELLELR-RKGREEKQQQRRERQDRVFQEEEEK-EWRKRETVLRKEEEK 259

Query: 399 QSEDTNTESKESDTKNE 415
             E+     +E   + E
Sbjct: 260 LQEEEPQRQRELQEEEE 276



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 81/384 (21%), Positives = 159/384 (41%), Gaps = 60/384 (15%)

Query: 64   ENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLA-----LSQNQQSSGA 118
            + L +QY K     +   E   LR       E E+R R+   R       L Q ++    
Sbjct: 1074 QELERQYRKEEELQQE--EEQLLR------EEPEKRRRQERERQCREEEELQQEEEQLLR 1125

Query: 119  AGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTST 178
                 +  ++++    + + + Q+ E+L  E    E +   +L  Q +EE EL +     
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEP--EKRRRQELERQYREEEELQQEEEQL 1183

Query: 179  IESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRT 238
            +     QEK+ +  E           Q R ++ L  ++     + +    +LK +     
Sbjct: 1184 LRE--EQEKRRQERE----------RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231

Query: 239  EEPDRDERLKKEKQEREE---------REKERERER-----EERERKRRREEEEREKERA 284
            E   RD ++  + +E E+         R+++ +++      E++ER R   E+ER + + 
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR---EQERRRWQQ 1288

Query: 285  RDR---ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRR----RSRSHD 337
            RDR   E  +  R   + + R  DR+    +   R    E+RR +  DR+         +
Sbjct: 1289 RDRHFPEEEQLEREEQKEAKR-RDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347

Query: 338  RSERKHRSRSRDRR------RSKSRDRKSYKHRSKSRDREQDRK--SKEKEKRGSDDKKS 389
            R E+  R + RDR+      R + + RK  +   + R +E++RK   +E++ R  + ++ 
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407

Query: 390  SVKSGSREKQSEDTNTESKESDTK 413
              +   R+ + E+     +E D K
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRK 1431



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 53/249 (21%), Positives = 112/249 (44%), Gaps = 39/249 (15%)

Query: 64   ENLRKQYEKSSRFMKVGYERDFLRYLQSLLA-EVERRIRRGHARLALSQNQQSSGAAGPT 122
            E  RK  E+  +  +   ER FL+  Q L   E+ER+ R        ++ +Q        
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL------- 1740

Query: 123  GKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESF 182
             + +E+ + + ++  +  ++ E+   + + +E     +  EQL++ERE  +  +   +  
Sbjct: 1741 -RRQERYRKILEEEQLRPEREEQ---QLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796

Query: 183  AAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPD 242
              +E+Q+               Q R +  L  +Q  G  + +    +L+E+ ++  +E D
Sbjct: 1797 FREEEQLR--------------QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD 1842

Query: 243  RD----------ERLKKEKQE---REEREKEREREREERERKRRREEEEREKERARDRER 289
            R           E+ ++E+QE    EE+++ +ERER+ RE   RR+++E ++ R     +
Sbjct: 1843 RQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIK 1902

Query: 290  RKRSRSRSR 298
             +  +   R
Sbjct: 1903 SQEGKGHGR 1911



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 40/173 (23%), Positives = 77/173 (44%), Gaps = 13/173 (7%)

Query: 256 EREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHK 315
           + EK    + +E   + RR+EE++ +   RDR+  +    R R   +  +R  +   +  
Sbjct: 96  DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE-- 153

Query: 316 RSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSR--DREQD 373
             +S ++ R   RDR+R R  +   ++   + R+ RR++    +S K        D EQ 
Sbjct: 154 --QSEKQERLEQRDRQR-RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210

Query: 374 RKSK--EKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIK 424
           R+ +  E  ++G ++K+       RE+Q      E ++   K E     E+ K
Sbjct: 211 RRRELLELRRKGREEKQQQ----RRERQDRVFQEEEEKEWRKRETVLRKEEEK 259


>gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]
          Length = 2426

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 72/221 (32%), Positives = 106/221 (47%), Gaps = 18/221 (8%)

Query: 220  YAKIKATVEELKEKLR--KRTEEPDRDERLK-KEKQEREEREKEREREREERERKRRREE 276
            + K+K T E+ K+     K  +E  RD  L+ + K+ +    K R+R  E R R R+R  
Sbjct: 1793 FVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSS 1852

Query: 277  EE---REKERARDRERRKRSRSRSRHSSR----TSDRRCSRSRDHK-RSRSRERRRSRSR 328
            +    R + R+R R RR+R  SRSR  SR     S  +  RS  H+ +SR R+R+RS SR
Sbjct: 1853 KSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSR 1912

Query: 329  DRR-----RSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383
            D R     RSR+  R  R H    R R RS  R R+S+      R R   R+S+   +R 
Sbjct: 1913 DNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGR-RRSFSISPSRRSRTPSRRSRTPSRRS 1971

Query: 384  -SDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDI 423
             +  ++S   S      S  + T S+   +++ V   S  I
Sbjct: 1972 RTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSI 2012



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 61/160 (38%), Positives = 89/160 (55%), Gaps = 16/160 (10%)

Query: 241  PDR-DERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRH 299
            P+R  E   +EK + E   K ++   + ++ K R   ++ EKE+ RD   R RS+ RS+ 
Sbjct: 1776 PERASESSSEEKDDYEIFVKVKDTHEKSKKNKNR---DKGEKEKKRDSSLRSRSK-RSKS 1831

Query: 300  SSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRR---SKSR 356
            S   S +R S SR   R RS + +  RS+ R RSRS  R  R  RSRS+ R R   SK +
Sbjct: 1832 SEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSR-RRRRSSRSRSKSRGRRSVSKEK 1890

Query: 357  DRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSR 396
             ++S KHRSKSR+R++ R S       S D + +V++ SR
Sbjct: 1891 RKRSPKHRSKSRERKRKRSS-------SRDNRKTVRARSR 1923



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 71/200 (35%), Positives = 106/200 (53%), Gaps = 21/200 (10%)

Query: 238  TEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRS 297
            +EE D  E   K K   E+ +K + R++ E+E+KR      R K   R +    +SR R+
Sbjct: 1784 SEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSK---RSKSSEHKSRKRT 1840

Query: 298  RHSSRTSDRRCSRSRDHK---RSRSRERRR---SRSRDR---RRSRSHDRSER--KHRSR 346
              S   + +R S+S+ H+   RSRSR RRR   SRSR +   RRS S ++ +R  KHRS+
Sbjct: 1841 SESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSK 1900

Query: 347  SRD--RRRSKSRD-RKSYKHRSK--SRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQ-- 399
            SR+  R+RS SRD RK+ + RS+  SR       S+ +  R    ++S   S SR  +  
Sbjct: 1901 SRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTP 1960

Query: 400  SEDTNTESKESDTKNEVNGT 419
            S  + T S+ S T +  + T
Sbjct: 1961 SRRSRTPSRRSRTPSRRSRT 1980



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 59/173 (34%), Positives = 86/173 (49%), Gaps = 17/173 (9%)

Query: 235  RKRTEEPDRDERLKKEKQEREEREKEREREREERER--KRRREEEEREKERARDRERRKR 292
            R +T    R  R ++  + R +    R   +E+R+R  K R +  ER+++R+  R+ RK 
Sbjct: 1858 RSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKT 1917

Query: 293  SRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSER----KHRSRSR 348
             R+RSR  SR       RSR H  SR   RRRSRS  RRRS S   S R      RSR+ 
Sbjct: 1918 VRARSRTPSR-------RSRSHTPSR---RRRSRSVGRRRSFSISPSRRSRTPSRRSRTP 1967

Query: 349  DRR-RSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
             RR R+ SR  ++   RS++  R     S+ +  R    ++S   S  R ++S
Sbjct: 1968 SRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRS 2020



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 65/202 (32%), Positives = 90/202 (44%), Gaps = 35/202 (17%)

Query: 215  KQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRR 274
            K H    + ++     +   R R++   R   + KEK++R  + + + RER+   RKR  
Sbjct: 1855 KSHRSQTRSRSRSRRRRRSSRSRSKSRGR-RSVSKEKRKRSPKHRSKSRERK---RKRSS 1910

Query: 275  EEEEREKERARDRERRKRSRSRS---RHSSRTSDRRCS-------RSRDHKRSRSRERRR 324
              + R+  RAR R   +RSRS +   R  SR+  RR S       RSR   R      RR
Sbjct: 1911 SRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRR 1970

Query: 325  SRSRDRR------RSRSHDRSER----KHRSRSRDRRRSKS-------RDRKSYKHR-SK 366
            SR+  RR      RSR+  R  R    + RSRS  RRRS S       R R   + R S+
Sbjct: 1971 SRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSR 2030

Query: 367  SRDREQDRKSKEKEKRGSDDKK 388
            S  R   RK     +RG   K+
Sbjct: 2031 SPIR---RKRSRSSERGRSPKR 2049



 Score = 35.8 bits (81), Expect = 0.078
 Identities = 23/126 (18%), Positives = 56/126 (44%), Gaps = 1/126 (0%)

Query: 292  RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRR 351
            R RS +     +   R S S   ++       + +    +  ++ +R + +   +     
Sbjct: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822

Query: 352  RSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESD 411
            RS+S+  KS +H+S+ R  E   +++++  + S   +S  +S SR ++   ++    +S 
Sbjct: 1823 RSRSKRSKSSEHKSRKRTSESRSRARKRSSK-SKSHRSQTRSRSRSRRRRRSSRSRSKSR 1881

Query: 412  TKNEVN 417
             +  V+
Sbjct: 1882 GRRSVS 1887



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 13/59 (22%), Positives = 35/59 (59%)

Query: 287 RERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRS 345
           +E  ++SR  S  +  T +    +S+ HK+ +++++++ + ++++  R  + SE K +S
Sbjct: 84  KEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKS 142



 Score = 30.4 bits (67), Expect = 3.3
 Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 1/92 (1%)

Query: 340  ERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQ 399
            ER   S S ++   +   +    H    +++ +D+  KEK KR S  +  S +S S E +
Sbjct: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEK-KRDSSLRSRSKRSKSSEHK 1835

Query: 400  SEDTNTESKESDTKNEVNGTSEDIKSEGDTQS 431
            S    +ES+    K      S   ++   ++S
Sbjct: 1836 SRKRTSESRSRARKRSSKSKSHRSQTRSRSRS 1867



 Score = 28.9 bits (63), Expect = 9.5
 Identities = 32/152 (21%), Positives = 58/152 (38%), Gaps = 18/152 (11%)

Query: 285  RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRS------RSHDR 338
            +D ER    R+        SD    RS       S   R S S    +       +  D 
Sbjct: 1740 KDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDT 1799

Query: 339  SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSK---EKEKRGSDDKKSSVKSGS 395
             E+  ++++RD+   + +   S + RSK        +SK    K ++ + + +S  +  S
Sbjct: 1800 HEKSKKNKNRDKGEKEKKRDSSLRSRSK--------RSKSSEHKSRKRTSESRSRARKRS 1851

Query: 396  REKQSEDTNTESKESDTKNEVNGTSEDIKSEG 427
             + +S  + T S+    +   +  S   KS G
Sbjct: 1852 SKSKSHRSQTRSRSRSRRRRRSSRSRS-KSRG 1882


>gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]
          Length = 2303

 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 72/221 (32%), Positives = 106/221 (47%), Gaps = 18/221 (8%)

Query: 220  YAKIKATVEELKEKLR--KRTEEPDRDERLK-KEKQEREEREKEREREREERERKRRREE 276
            + K+K T E+ K+     K  +E  RD  L+ + K+ +    K R+R  E R R R+R  
Sbjct: 1793 FVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSS 1852

Query: 277  EE---REKERARDRERRKRSRSRSRHSSR----TSDRRCSRSRDHK-RSRSRERRRSRSR 328
            +    R + R+R R RR+R  SRSR  SR     S  +  RS  H+ +SR R+R+RS SR
Sbjct: 1853 KSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSR 1912

Query: 329  DRR-----RSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRG 383
            D R     RSR+  R  R H    R R RS  R R+S+      R R   R+S+   +R 
Sbjct: 1913 DNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGR-RRSFSISPSRRSRTPSRRSRTPSRRS 1971

Query: 384  -SDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDI 423
             +  ++S   S      S  + T S+   +++ V   S  I
Sbjct: 1972 RTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSI 2012



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 61/160 (38%), Positives = 89/160 (55%), Gaps = 16/160 (10%)

Query: 241  PDR-DERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRH 299
            P+R  E   +EK + E   K ++   + ++ K R   ++ EKE+ RD   R RS+ RS+ 
Sbjct: 1776 PERASESSSEEKDDYEIFVKVKDTHEKSKKNKNR---DKGEKEKKRDSSLRSRSK-RSKS 1831

Query: 300  SSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRR---SKSR 356
            S   S +R S SR   R RS + +  RS+ R RSRS  R  R  RSRS+ R R   SK +
Sbjct: 1832 SEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSR-RRRRSSRSRSKSRGRRSVSKEK 1890

Query: 357  DRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSR 396
             ++S KHRSKSR+R++ R S       S D + +V++ SR
Sbjct: 1891 RKRSPKHRSKSRERKRKRSS-------SRDNRKTVRARSR 1923



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 71/200 (35%), Positives = 106/200 (53%), Gaps = 21/200 (10%)

Query: 238  TEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRS 297
            +EE D  E   K K   E+ +K + R++ E+E+KR      R K   R +    +SR R+
Sbjct: 1784 SEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSK---RSKSSEHKSRKRT 1840

Query: 298  RHSSRTSDRRCSRSRDHK---RSRSRERRR---SRSRDR---RRSRSHDRSER--KHRSR 346
              S   + +R S+S+ H+   RSRSR RRR   SRSR +   RRS S ++ +R  KHRS+
Sbjct: 1841 SESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSK 1900

Query: 347  SRD--RRRSKSRD-RKSYKHRSK--SRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQ-- 399
            SR+  R+RS SRD RK+ + RS+  SR       S+ +  R    ++S   S SR  +  
Sbjct: 1901 SRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTP 1960

Query: 400  SEDTNTESKESDTKNEVNGT 419
            S  + T S+ S T +  + T
Sbjct: 1961 SRRSRTPSRRSRTPSRRSRT 1980



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 59/173 (34%), Positives = 86/173 (49%), Gaps = 17/173 (9%)

Query: 235  RKRTEEPDRDERLKKEKQEREEREKEREREREERER--KRRREEEEREKERARDRERRKR 292
            R +T    R  R ++  + R +    R   +E+R+R  K R +  ER+++R+  R+ RK 
Sbjct: 1858 RSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKT 1917

Query: 293  SRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSER----KHRSRSR 348
             R+RSR  SR       RSR H  SR   RRRSRS  RRRS S   S R      RSR+ 
Sbjct: 1918 VRARSRTPSR-------RSRSHTPSR---RRRSRSVGRRRSFSISPSRRSRTPSRRSRTP 1967

Query: 349  DRR-RSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQS 400
             RR R+ SR  ++   RS++  R     S+ +  R    ++S   S  R ++S
Sbjct: 1968 SRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRS 2020



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 65/202 (32%), Positives = 90/202 (44%), Gaps = 35/202 (17%)

Query: 215  KQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRR 274
            K H    + ++     +   R R++   R   + KEK++R  + + + RER+   RKR  
Sbjct: 1855 KSHRSQTRSRSRSRRRRRSSRSRSKSRGR-RSVSKEKRKRSPKHRSKSRERK---RKRSS 1910

Query: 275  EEEEREKERARDRERRKRSRSRS---RHSSRTSDRRCS-------RSRDHKRSRSRERRR 324
              + R+  RAR R   +RSRS +   R  SR+  RR S       RSR   R      RR
Sbjct: 1911 SRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRR 1970

Query: 325  SRSRDRR------RSRSHDRSER----KHRSRSRDRRRSKS-------RDRKSYKHR-SK 366
            SR+  RR      RSR+  R  R    + RSRS  RRRS S       R R   + R S+
Sbjct: 1971 SRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSR 2030

Query: 367  SRDREQDRKSKEKEKRGSDDKK 388
            S  R   RK     +RG   K+
Sbjct: 2031 SPIR---RKRSRSSERGRSPKR 2049



 Score = 35.8 bits (81), Expect = 0.078
 Identities = 23/126 (18%), Positives = 56/126 (44%), Gaps = 1/126 (0%)

Query: 292  RSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRR 351
            R RS +     +   R S S   ++       + +    +  ++ +R + +   +     
Sbjct: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822

Query: 352  RSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESD 411
            RS+S+  KS +H+S+ R  E   +++++  + S   +S  +S SR ++   ++    +S 
Sbjct: 1823 RSRSKRSKSSEHKSRKRTSESRSRARKRSSK-SKSHRSQTRSRSRSRRRRRSSRSRSKSR 1881

Query: 412  TKNEVN 417
             +  V+
Sbjct: 1882 GRRSVS 1887



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 13/59 (22%), Positives = 35/59 (59%)

Query: 287 RERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRS 345
           +E  ++SR  S  +  T +    +S+ HK+ +++++++ + ++++  R  + SE K +S
Sbjct: 84  KEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKS 142



 Score = 30.4 bits (67), Expect = 3.3
 Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 1/92 (1%)

Query: 340  ERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQ 399
            ER   S S ++   +   +    H    +++ +D+  KEK KR S  +  S +S S E +
Sbjct: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEK-KRDSSLRSRSKRSKSSEHK 1835

Query: 400  SEDTNTESKESDTKNEVNGTSEDIKSEGDTQS 431
            S    +ES+    K      S   ++   ++S
Sbjct: 1836 SRKRTSESRSRARKRSSKSKSHRSQTRSRSRS 1867



 Score = 28.9 bits (63), Expect = 9.5
 Identities = 32/152 (21%), Positives = 58/152 (38%), Gaps = 18/152 (11%)

Query: 285  RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRS------RSHDR 338
            +D ER    R+        SD    RS       S   R S S    +       +  D 
Sbjct: 1740 KDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDT 1799

Query: 339  SERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSK---EKEKRGSDDKKSSVKSGS 395
             E+  ++++RD+   + +   S + RSK        +SK    K ++ + + +S  +  S
Sbjct: 1800 HEKSKKNKNRDKGEKEKKRDSSLRSRSK--------RSKSSEHKSRKRTSESRSRARKRS 1851

Query: 396  REKQSEDTNTESKESDTKNEVNGTSEDIKSEG 427
             + +S  + T S+    +   +  S   KS G
Sbjct: 1852 SKSKSHRSQTRSRSRSRRRRRSSRSRS-KSRG 1882


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.125    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,724,560
Number of Sequences: 37866
Number of extensions: 793576
Number of successful extensions: 69089
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1446
Number of HSP's successfully gapped in prelim test: 934
Number of HSP's that attempted gapping in prelim test: 9835
Number of HSP's gapped (non-prelim): 19208
length of query: 432
length of database: 18,247,518
effective HSP length: 105
effective length of query: 327
effective length of database: 14,271,588
effective search space: 4666809276
effective search space used: 4666809276
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
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