BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|19913412 major vault protein [Homo sapiens] (893 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|19913410 major vault protein [Homo sapiens] 1753 0.0 gi|19913412 major vault protein [Homo sapiens] 1753 0.0 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 47 1e-04 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 47 1e-04 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 47 1e-04 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 47 1e-04 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 47 1e-04 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 47 1e-04 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 47 1e-04 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 47 1e-04 gi|94538362 flotillin 2 [Homo sapiens] 46 2e-04 gi|191252785 centrobin, centrosomal BRCA2 interacting protein is... 46 2e-04 gi|80861396 centrobin, centrosomal BRCA2 interacting protein iso... 46 2e-04 gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 45 3e-04 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 44 7e-04 gi|157042792 coiled-coil domain containing 64B [Homo sapiens] 44 7e-04 gi|93102364 SWAP-70 protein [Homo sapiens] 44 9e-04 gi|154354979 myosin X [Homo sapiens] 44 9e-04 gi|115648142 centrosomal protein 164kDa [Homo sapiens] 43 0.001 gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 43 0.001 gi|4504063 golgin 97 [Homo sapiens] 43 0.001 gi|31982906 cingulin-like 1 [Homo sapiens] 43 0.001 gi|4505101 microtubule-associated protein 7 [Homo sapiens] 43 0.001 gi|87298937 centrosomal protein 110kDa [Homo sapiens] 43 0.001 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 42 0.002 gi|35038601 spindle assembly abnormal protein 6 [Homo sapiens] 42 0.003 gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 42 0.003 gi|5031699 flotillin 1 [Homo sapiens] 42 0.003 gi|4505257 moesin [Homo sapiens] 42 0.003 gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 42 0.003 >gi|19913410 major vault protein [Homo sapiens] Length = 893 Score = 1753 bits (4541), Expect = 0.0 Identities = 893/893 (100%), Positives = 893/893 (100%) Query: 1 MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCT 60 MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCT Sbjct: 1 MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCT 60 Query: 61 VANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTA 120 VANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTA Sbjct: 61 VANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTA 120 Query: 121 LHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARK 180 LHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARK Sbjct: 121 LHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARK 180 Query: 181 ECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRG 240 ECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRG Sbjct: 181 ECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRG 240 Query: 241 VSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKR 300 VSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKR Sbjct: 241 VSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKR 300 Query: 301 VVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIR 360 VVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIR Sbjct: 301 VVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIR 360 Query: 361 GPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELP 420 GPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELP Sbjct: 361 GPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELP 420 Query: 421 PGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARV 480 PGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARV Sbjct: 421 PGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARV 480 Query: 481 VFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQ 540 VFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQ Sbjct: 481 VFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQ 540 Query: 541 LAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIR 600 LAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIR Sbjct: 541 LAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIR 600 Query: 601 TAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQL 660 TAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQL Sbjct: 601 TAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQL 660 Query: 661 AIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTG 720 AIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTG Sbjct: 661 AIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTG 720 Query: 721 TAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELE 780 TAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELE Sbjct: 721 TAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELE 780 Query: 781 VSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPIN 840 VSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPIN Sbjct: 781 VSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPIN 840 Query: 841 LFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR 893 LFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR Sbjct: 841 LFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR 893 >gi|19913412 major vault protein [Homo sapiens] Length = 893 Score = 1753 bits (4541), Expect = 0.0 Identities = 893/893 (100%), Positives = 893/893 (100%) Query: 1 MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCT 60 MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCT Sbjct: 1 MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCT 60 Query: 61 VANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTA 120 VANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTA Sbjct: 61 VANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTA 120 Query: 121 LHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARK 180 LHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARK Sbjct: 121 LHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARK 180 Query: 181 ECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRG 240 ECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRG Sbjct: 181 ECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRG 240 Query: 241 VSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKR 300 VSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKR Sbjct: 241 VSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKR 300 Query: 301 VVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIR 360 VVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIR Sbjct: 301 VVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIR 360 Query: 361 GPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELP 420 GPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELP Sbjct: 361 GPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELP 420 Query: 421 PGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARV 480 PGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARV Sbjct: 421 PGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARV 480 Query: 481 VFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQ 540 VFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQ Sbjct: 481 VFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQ 540 Query: 541 LAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIR 600 LAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIR Sbjct: 541 LAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIR 600 Query: 601 TAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQL 660 TAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQL Sbjct: 601 TAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQL 660 Query: 661 AIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTG 720 AIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTG Sbjct: 661 AIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTG 720 Query: 721 TAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELE 780 TAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELE Sbjct: 721 TAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELE 780 Query: 781 VSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPIN 840 VSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPIN Sbjct: 781 VSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPIN 840 Query: 841 LFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR 893 LFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR Sbjct: 841 LFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR 893 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 46.6 bits (109), Expect = 1e-04 Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 13/152 (8%) Query: 648 QRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 Q+ LQ+++Q + + EA A A +EAR + ER EA ++R+++ Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-------EAAQSRRQV 2111 Query: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSV---LQAKLKAQALAIETEAELQRVQ 763 E E L + E A+A+A++ AE R E E QA+ A +AE+++ + Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171 Query: 764 KVRELELVYARAQLELEVSKAQ-QLAEVEVKK 794 K E + + +AQ+E E++ + QL E + +K Sbjct: 2172 KFAE-QTLRQKAQVEQELTTLRLQLEETDHQK 2202 Score = 45.4 bits (106), Expect = 2e-04 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 28/154 (18%) Query: 669 QEAAAKHEAQRLEQEA------RGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 Q++ A+ EA++ ++EA RG+ E Q + + AE+ ELE E T Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ------ELEKQRQLAEGTAQQ 1707 Query: 723 KAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV- 781 + AE R E E Q +L + LA QK +ELE A+ + E+EV Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767 Query: 782 ---------------SKAQQLAEVEVKKFKQMTE 800 K++Q E E +F+++ E Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801 Score = 45.1 bits (105), Expect = 3e-04 Identities = 50/159 (31%), Positives = 75/159 (47%), Gaps = 8/159 (5%) Query: 648 QRTRDALQRS-VQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQ----SEAEKA 702 + T A QRS V+ + E +K +A R+E E R + R K Q EAEK Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKA-RIEAENRALILRDKDNTQRFLQEEAEKM 2273 Query: 703 RKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRV 762 ++ E LS+A + + AE R E +L+ K++A A +AE + + Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELL 2332 Query: 763 QKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEA 801 Q+ +EL AR E + AQQLAE E + F++ EA Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEA 2370 Score = 44.3 bits (103), Expect = 5e-04 Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 33/189 (17%) Query: 644 EPVDQRTRDALQRSVQLAIEITTNSQEA--AAKHEAQRLEQEARGRLERQKILDQSE--- 698 E + + R A + + +L ++ SQ A A R++ EA E+Q+ L E Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542 Query: 699 --AEKARKELLELEA-----LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL 751 AE+A + L + E + +A+E T AEAE +++ A + + L+ L+ + + Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1601 Query: 752 AI-------------ETEAELQRVQKVRELELVYARAQLEL-------EVSKAQQLAEVE 791 A+ + EAE R + RELE +A L EV++ + LA+ E Sbjct: 1602 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1661 Query: 792 VKKFKQMTE 800 +K K+ E Sbjct: 1662 AEKQKEEAE 1670 Score = 43.5 bits (101), Expect = 9e-04 Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 15/156 (9%) Query: 647 DQRTRDALQR-SVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKE 705 ++R R+A +R LA E Q AA E +RL+ + E +++ +++E E AR+ Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE---EARRLRERAEQESARQL 2036 Query: 706 LLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKL-KAQALAIETEAELQRVQK 764 L EA + +AE +A A ++ + LQ L + Q++ + E + ++ Sbjct: 2037 QLAQEA--------AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088 Query: 765 VRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTE 800 E E AR Q E E +++++ E E ++ KQ E Sbjct: 2089 AAE-EAEEARVQAEREAAQSRRQVE-EAERLKQSAE 2122 Score = 43.5 bits (101), Expect = 9e-04 Identities = 48/170 (28%), Positives = 81/170 (47%), Gaps = 19/170 (11%) Query: 641 QSVEPVDQRTR-----DALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILD 695 + ++ V + TR + LQ+ +LA E QE + AQ+L +E +G Q+ L Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK-EQMAQQLAEETQGF---QRTL- 2368 Query: 696 QSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIET 755 EAE+ R+ + EA + + ++A+A + +A R + + KL LA + Sbjct: 2369 --EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426 Query: 756 EA------ELQRVQKVRELE-LVYARAQLELEVSKAQQLAEVEVKKFKQM 798 + E+QR Q + E L A A+LE E K QQ A++ K ++M Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476 Score = 41.2 bits (95), Expect = 0.004 Identities = 41/140 (29%), Positives = 67/140 (47%), Gaps = 11/140 (7%) Query: 653 ALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEA 711 AL++ QLA ++Q +A A+ EA+ L+Q + + R++ ++ R EL+ Sbjct: 1368 ALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424 Query: 712 LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELV 771 L + E+ AKA AE +R+ E + +L+ +A E QR EL+ + Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------TERQRGGAEGELQAL 1478 Query: 772 YARAQLELEVSKAQQLAEVE 791 ARA+ E E K Q E E Sbjct: 1479 RARAE-EAEAQKRQAQEEAE 1497 Score = 41.2 bits (95), Expect = 0.004 Identities = 47/169 (27%), Positives = 76/169 (44%), Gaps = 13/169 (7%) Query: 669 QEAAAKHEAQ------RLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 +E AA+H+A +L + + LERQK L + + R+ E+ AL + E Sbjct: 1881 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940 Query: 723 KAEAESRAEAARIEGEGSVL---QAKLKAQALAIETEAELQRVQKVRELELVYARAQLEL 779 KAE E R E ++ QA+L+A A + AE +R ++ E E V E Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEA-ARQRQLAAEEERRRREAE-ERVQKSLAAEE 1998 Query: 780 EVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLK 828 E ++ ++ A EV++ K E +R+ A Q++L Q K Sbjct: 1999 EAARQRKAALEEVERLKAKVEE--ARRLRERAEQESARQLQLAQEAAQK 2045 Score = 40.4 bits (93), Expect = 0.007 Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 14/155 (9%) Query: 648 QRTRDALQ--RSVQLAIEITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAE 700 Q R+A Q R V+ A + +++E A A+ A++L +EA R+ +Q+ Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL----AIETE 756 + + E+E E T KA+ E R++ E + Q L + L A TE Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218 Query: 757 AELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791 A QR Q E EL R Q+E E+SK + E E Sbjct: 2219 AARQRSQV--EEELFSVRVQME-ELSKLKARIEAE 2250 Score = 39.7 bits (91), Expect = 0.013 Identities = 43/179 (24%), Positives = 84/179 (46%), Gaps = 20/179 (11%) Query: 641 QSVEPVDQRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEA 699 +++E QR + + +L + + S+ +A A+ +AQR ++A E+ + + Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425 Query: 700 EKARK-ELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAE 758 EK + LE++ ++ +A AE E +++ E +LQ K + + ++ E Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTVQQEQL 2484 Query: 759 LQRVQKV-------------RELELVYARAQLEL----EVSKAQQLAEVEVKKFKQMTE 800 LQ Q + RE + +A+LE EV+KAQQL E + ++ +QM + Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543 Score = 38.1 bits (87), Expect = 0.037 Identities = 43/180 (23%), Positives = 87/180 (48%), Gaps = 23/180 (12%) Query: 662 IEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGT 721 +E + + A + E+ A+ + E ++ +++E E R +L EAL + +++ Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1651 Query: 722 AKAEAESRAEAARIEGEGS-VLQAKLKAQALAI-ETEAELQRVQKVREL----------- 768 A+ ++ ++AEA + + E + + KA+ A+ + E Q ++K R+L Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1711 Query: 769 --ELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIR-----DLAVAGPEMQVKL 821 EL+ RA+ E + + +QL E E+ + ++ EA + R +LA EM+V L Sbjct: 1712 EQELIRLRAETE-QGEQQRQLLEEELARLQR--EAAAATQKRQELEAELAKVRAEMEVLL 1768 Score = 35.8 bits (81), Expect = 0.18 Identities = 26/120 (21%), Positives = 56/120 (46%), Gaps = 4/120 (3%) Query: 683 EARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVL 742 E R+E ++ L + + + R+ L E+EA A A+A+++AE E + + Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398 Query: 743 QAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAI 802 + ++ + A++ + + + +Q+ EL R E E+ + AE + ++ E I Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQE----ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 46.6 bits (109), Expect = 1e-04 Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 13/152 (8%) Query: 648 QRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 Q+ LQ+++Q + + EA A A +EAR + ER EA ++R+++ Sbjct: 2063 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-------EAAQSRRQV 2115 Query: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSV---LQAKLKAQALAIETEAELQRVQ 763 E E L + E A+A+A++ AE R E E QA+ A +AE+++ + Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175 Query: 764 KVRELELVYARAQLELEVSKAQ-QLAEVEVKK 794 K E + + +AQ+E E++ + QL E + +K Sbjct: 2176 KFAE-QTLRQKAQVEQELTTLRLQLEETDHQK 2206 Score = 45.4 bits (106), Expect = 2e-04 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 28/154 (18%) Query: 669 QEAAAKHEAQRLEQEA------RGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 Q++ A+ EA++ ++EA RG+ E Q + + AE+ ELE E T Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ------ELEKQRQLAEGTAQQ 1711 Query: 723 KAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV- 781 + AE R E E Q +L + LA QK +ELE A+ + E+EV Sbjct: 1712 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1771 Query: 782 ---------------SKAQQLAEVEVKKFKQMTE 800 K++Q E E +F+++ E Sbjct: 1772 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805 Score = 45.1 bits (105), Expect = 3e-04 Identities = 50/159 (31%), Positives = 75/159 (47%), Gaps = 8/159 (5%) Query: 648 QRTRDALQRS-VQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQ----SEAEKA 702 + T A QRS V+ + E +K +A R+E E R + R K Q EAEK Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSKLKA-RIEAENRALILRDKDNTQRFLQEEAEKM 2277 Query: 703 RKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRV 762 ++ E LS+A + + AE R E +L+ K++A A +AE + + Sbjct: 2278 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELL 2336 Query: 763 QKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEA 801 Q+ +EL AR E + AQQLAE E + F++ EA Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEA 2374 Score = 44.3 bits (103), Expect = 5e-04 Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 33/189 (17%) Query: 644 EPVDQRTRDALQRSVQLAIEITTNSQEA--AAKHEAQRLEQEARGRLERQKILDQSE--- 698 E + + R A + + +L ++ SQ A A R++ EA E+Q+ L E Sbjct: 1487 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1546 Query: 699 --AEKARKELLELEA-----LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL 751 AE+A + L + E + +A+E T AEAE +++ A + + L+ L+ + + Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1605 Query: 752 AI-------------ETEAELQRVQKVRELELVYARAQLEL-------EVSKAQQLAEVE 791 A+ + EAE R + RELE +A L EV++ + LA+ E Sbjct: 1606 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1665 Query: 792 VKKFKQMTE 800 +K K+ E Sbjct: 1666 AEKQKEEAE 1674 Score = 43.5 bits (101), Expect = 9e-04 Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 15/156 (9%) Query: 647 DQRTRDALQR-SVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKE 705 ++R R+A +R LA E Q AA E +RL+ + E +++ +++E E AR+ Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE---EARRLRERAEQESARQL 2040 Query: 706 LLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKL-KAQALAIETEAELQRVQK 764 L EA + +AE +A A ++ + LQ L + Q++ + E + ++ Sbjct: 2041 QLAQEA--------AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092 Query: 765 VRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTE 800 E E AR Q E E +++++ E E ++ KQ E Sbjct: 2093 AAE-EAEEARVQAEREAAQSRRQVE-EAERLKQSAE 2126 Score = 43.5 bits (101), Expect = 9e-04 Identities = 48/170 (28%), Positives = 81/170 (47%), Gaps = 19/170 (11%) Query: 641 QSVEPVDQRTR-----DALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILD 695 + ++ V + TR + LQ+ +LA E QE + AQ+L +E +G Q+ L Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK-EQMAQQLAEETQGF---QRTL- 2372 Query: 696 QSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIET 755 EAE+ R+ + EA + + ++A+A + +A R + + KL LA + Sbjct: 2373 --EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2430 Query: 756 EA------ELQRVQKVRELE-LVYARAQLELEVSKAQQLAEVEVKKFKQM 798 + E+QR Q + E L A A+LE E K QQ A++ K ++M Sbjct: 2431 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480 Score = 41.2 bits (95), Expect = 0.004 Identities = 41/140 (29%), Positives = 67/140 (47%), Gaps = 11/140 (7%) Query: 653 ALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEA 711 AL++ QLA ++Q +A A+ EA+ L+Q + + R++ ++ R EL+ Sbjct: 1372 ALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1428 Query: 712 LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELV 771 L + E+ AKA AE +R+ E + +L+ +A E QR EL+ + Sbjct: 1429 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------TERQRGGAEGELQAL 1482 Query: 772 YARAQLELEVSKAQQLAEVE 791 ARA+ E E K Q E E Sbjct: 1483 RARAE-EAEAQKRQAQEEAE 1501 Score = 41.2 bits (95), Expect = 0.004 Identities = 47/169 (27%), Positives = 76/169 (44%), Gaps = 13/169 (7%) Query: 669 QEAAAKHEAQ------RLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 +E AA+H+A +L + + LERQK L + + R+ E+ AL + E Sbjct: 1885 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1944 Query: 723 KAEAESRAEAARIEGEGSVL---QAKLKAQALAIETEAELQRVQKVRELELVYARAQLEL 779 KAE E R E ++ QA+L+A A + AE +R ++ E E V E Sbjct: 1945 KAELELELGRIRSNAEDTLRSKEQAELEA-ARQRQLAAEEERRRREAE-ERVQKSLAAEE 2002 Query: 780 EVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLK 828 E ++ ++ A EV++ K E +R+ A Q++L Q K Sbjct: 2003 EAARQRKAALEEVERLKAKVEE--ARRLRERAEQESARQLQLAQEAAQK 2049 Score = 40.4 bits (93), Expect = 0.007 Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 14/155 (9%) Query: 648 QRTRDALQ--RSVQLAIEITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAE 700 Q R+A Q R V+ A + +++E A A+ A++L +EA R+ +Q+ Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2162 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL----AIETE 756 + + E+E E T KA+ E R++ E + Q L + L A TE Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222 Query: 757 AELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791 A QR Q E EL R Q+E E+SK + E E Sbjct: 2223 AARQRSQV--EEELFSVRVQME-ELSKLKARIEAE 2254 Score = 39.7 bits (91), Expect = 0.013 Identities = 43/179 (24%), Positives = 84/179 (46%), Gaps = 20/179 (11%) Query: 641 QSVEPVDQRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEA 699 +++E QR + + +L + + S+ +A A+ +AQR ++A E+ + + Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2429 Query: 700 EKARK-ELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAE 758 EK + LE++ ++ +A AE E +++ E +LQ K + + ++ E Sbjct: 2430 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTVQQEQL 2488 Query: 759 LQRVQKV-------------RELELVYARAQLEL----EVSKAQQLAEVEVKKFKQMTE 800 LQ Q + RE + +A+LE EV+KAQQL E + ++ +QM + Sbjct: 2489 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547 Score = 38.1 bits (87), Expect = 0.037 Identities = 43/180 (23%), Positives = 87/180 (48%), Gaps = 23/180 (12%) Query: 662 IEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGT 721 +E + + A + E+ A+ + E ++ +++E E R +L EAL + +++ Sbjct: 1596 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1655 Query: 722 AKAEAESRAEAARIEGEGS-VLQAKLKAQALAI-ETEAELQRVQKVREL----------- 768 A+ ++ ++AEA + + E + + KA+ A+ + E Q ++K R+L Sbjct: 1656 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1715 Query: 769 --ELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIR-----DLAVAGPEMQVKL 821 EL+ RA+ E + + +QL E E+ + ++ EA + R +LA EM+V L Sbjct: 1716 EQELIRLRAETE-QGEQQRQLLEEELARLQR--EAAAATQKRQELEAELAKVRAEMEVLL 1772 Score = 35.8 bits (81), Expect = 0.18 Identities = 26/120 (21%), Positives = 56/120 (46%), Gaps = 4/120 (3%) Query: 683 EARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVL 742 E R+E ++ L + + + R+ L E+EA A A+A+++AE E + + Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402 Query: 743 QAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAI 802 + ++ + A++ + + + +Q+ EL R E E+ + AE + ++ E I Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQE----ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 46.6 bits (109), Expect = 1e-04 Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 13/152 (8%) Query: 648 QRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 Q+ LQ+++Q + + EA A A +EAR + ER EA ++R+++ Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-------EAAQSRRQV 2111 Query: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSV---LQAKLKAQALAIETEAELQRVQ 763 E E L + E A+A+A++ AE R E E QA+ A +AE+++ + Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171 Query: 764 KVRELELVYARAQLELEVSKAQ-QLAEVEVKK 794 K E + + +AQ+E E++ + QL E + +K Sbjct: 2172 KFAE-QTLRQKAQVEQELTTLRLQLEETDHQK 2202 Score = 45.4 bits (106), Expect = 2e-04 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 28/154 (18%) Query: 669 QEAAAKHEAQRLEQEA------RGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 Q++ A+ EA++ ++EA RG+ E Q + + AE+ ELE E T Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ------ELEKQRQLAEGTAQQ 1707 Query: 723 KAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV- 781 + AE R E E Q +L + LA QK +ELE A+ + E+EV Sbjct: 1708 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1767 Query: 782 ---------------SKAQQLAEVEVKKFKQMTE 800 K++Q E E +F+++ E Sbjct: 1768 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801 Score = 45.1 bits (105), Expect = 3e-04 Identities = 50/159 (31%), Positives = 75/159 (47%), Gaps = 8/159 (5%) Query: 648 QRTRDALQRS-VQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQ----SEAEKA 702 + T A QRS V+ + E +K +A R+E E R + R K Q EAEK Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKA-RIEAENRALILRDKDNTQRFLQEEAEKM 2273 Query: 703 RKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRV 762 ++ E LS+A + + AE R E +L+ K++A A +AE + + Sbjct: 2274 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELL 2332 Query: 763 QKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEA 801 Q+ +EL AR E + AQQLAE E + F++ EA Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEA 2370 Score = 44.3 bits (103), Expect = 5e-04 Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 33/189 (17%) Query: 644 EPVDQRTRDALQRSVQLAIEITTNSQEA--AAKHEAQRLEQEARGRLERQKILDQSE--- 698 E + + R A + + +L ++ SQ A A R++ EA E+Q+ L E Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542 Query: 699 --AEKARKELLELEA-----LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL 751 AE+A + L + E + +A+E T AEAE +++ A + + L+ L+ + + Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1601 Query: 752 AI-------------ETEAELQRVQKVRELELVYARAQLEL-------EVSKAQQLAEVE 791 A+ + EAE R + RELE +A L EV++ + LA+ E Sbjct: 1602 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1661 Query: 792 VKKFKQMTE 800 +K K+ E Sbjct: 1662 AEKQKEEAE 1670 Score = 43.5 bits (101), Expect = 9e-04 Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 15/156 (9%) Query: 647 DQRTRDALQR-SVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKE 705 ++R R+A +R LA E Q AA E +RL+ + E +++ +++E E AR+ Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE---EARRLRERAEQESARQL 2036 Query: 706 LLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKL-KAQALAIETEAELQRVQK 764 L EA + +AE +A A ++ + LQ L + Q++ + E + ++ Sbjct: 2037 QLAQEA--------AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088 Query: 765 VRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTE 800 E E AR Q E E +++++ E E ++ KQ E Sbjct: 2089 AAE-EAEEARVQAEREAAQSRRQVE-EAERLKQSAE 2122 Score = 43.5 bits (101), Expect = 9e-04 Identities = 48/170 (28%), Positives = 81/170 (47%), Gaps = 19/170 (11%) Query: 641 QSVEPVDQRTR-----DALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILD 695 + ++ V + TR + LQ+ +LA E QE + AQ+L +E +G Q+ L Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK-EQMAQQLAEETQGF---QRTL- 2368 Query: 696 QSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIET 755 EAE+ R+ + EA + + ++A+A + +A R + + KL LA + Sbjct: 2369 --EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426 Query: 756 EA------ELQRVQKVRELE-LVYARAQLELEVSKAQQLAEVEVKKFKQM 798 + E+QR Q + E L A A+LE E K QQ A++ K ++M Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476 Score = 41.2 bits (95), Expect = 0.004 Identities = 41/140 (29%), Positives = 67/140 (47%), Gaps = 11/140 (7%) Query: 653 ALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEA 711 AL++ QLA ++Q +A A+ EA+ L+Q + + R++ ++ R EL+ Sbjct: 1368 ALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1424 Query: 712 LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELV 771 L + E+ AKA AE +R+ E + +L+ +A E QR EL+ + Sbjct: 1425 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------TERQRGGAEGELQAL 1478 Query: 772 YARAQLELEVSKAQQLAEVE 791 ARA+ E E K Q E E Sbjct: 1479 RARAE-EAEAQKRQAQEEAE 1497 Score = 41.2 bits (95), Expect = 0.004 Identities = 47/169 (27%), Positives = 76/169 (44%), Gaps = 13/169 (7%) Query: 669 QEAAAKHEAQ------RLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 +E AA+H+A +L + + LERQK L + + R+ E+ AL + E Sbjct: 1881 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940 Query: 723 KAEAESRAEAARIEGEGSVL---QAKLKAQALAIETEAELQRVQKVRELELVYARAQLEL 779 KAE E R E ++ QA+L+A A + AE +R ++ E E V E Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEA-ARQRQLAAEEERRRREAE-ERVQKSLAAEE 1998 Query: 780 EVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLK 828 E ++ ++ A EV++ K E +R+ A Q++L Q K Sbjct: 1999 EAARQRKAALEEVERLKAKVEE--ARRLRERAEQESARQLQLAQEAAQK 2045 Score = 40.4 bits (93), Expect = 0.007 Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 14/155 (9%) Query: 648 QRTRDALQ--RSVQLAIEITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAE 700 Q R+A Q R V+ A + +++E A A+ A++L +EA R+ +Q+ Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL----AIETE 756 + + E+E E T KA+ E R++ E + Q L + L A TE Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218 Query: 757 AELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791 A QR Q E EL R Q+E E+SK + E E Sbjct: 2219 AARQRSQV--EEELFSVRVQME-ELSKLKARIEAE 2250 Score = 39.7 bits (91), Expect = 0.013 Identities = 43/179 (24%), Positives = 84/179 (46%), Gaps = 20/179 (11%) Query: 641 QSVEPVDQRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEA 699 +++E QR + + +L + + S+ +A A+ +AQR ++A E+ + + Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425 Query: 700 EKARK-ELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAE 758 EK + LE++ ++ +A AE E +++ E +LQ K + + ++ E Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTVQQEQL 2484 Query: 759 LQRVQKV-------------RELELVYARAQLEL----EVSKAQQLAEVEVKKFKQMTE 800 LQ Q + RE + +A+LE EV+KAQQL E + ++ +QM + Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543 Score = 38.1 bits (87), Expect = 0.037 Identities = 43/180 (23%), Positives = 87/180 (48%), Gaps = 23/180 (12%) Query: 662 IEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGT 721 +E + + A + E+ A+ + E ++ +++E E R +L EAL + +++ Sbjct: 1592 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1651 Query: 722 AKAEAESRAEAARIEGEGS-VLQAKLKAQALAI-ETEAELQRVQKVREL----------- 768 A+ ++ ++AEA + + E + + KA+ A+ + E Q ++K R+L Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1711 Query: 769 --ELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIR-----DLAVAGPEMQVKL 821 EL+ RA+ E + + +QL E E+ + ++ EA + R +LA EM+V L Sbjct: 1712 EQELIRLRAETE-QGEQQRQLLEEELARLQR--EAAAATQKRQELEAELAKVRAEMEVLL 1768 Score = 35.8 bits (81), Expect = 0.18 Identities = 26/120 (21%), Positives = 56/120 (46%), Gaps = 4/120 (3%) Query: 683 EARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVL 742 E R+E ++ L + + + R+ L E+EA A A+A+++AE E + + Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398 Query: 743 QAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAI 802 + ++ + A++ + + + +Q+ EL R E E+ + AE + ++ E I Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQE----ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 46.6 bits (109), Expect = 1e-04 Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 13/152 (8%) Query: 648 QRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 Q+ LQ+++Q + + EA A A +EAR + ER EA ++R+++ Sbjct: 2027 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-------EAAQSRRQV 2079 Query: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSV---LQAKLKAQALAIETEAELQRVQ 763 E E L + E A+A+A++ AE R E E QA+ A +AE+++ + Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139 Query: 764 KVRELELVYARAQLELEVSKAQ-QLAEVEVKK 794 K E + + +AQ+E E++ + QL E + +K Sbjct: 2140 KFAE-QTLRQKAQVEQELTTLRLQLEETDHQK 2170 Score = 45.4 bits (106), Expect = 2e-04 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 28/154 (18%) Query: 669 QEAAAKHEAQRLEQEA------RGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 Q++ A+ EA++ ++EA RG+ E Q + + AE+ ELE E T Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ------ELEKQRQLAEGTAQQ 1675 Query: 723 KAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV- 781 + AE R E E Q +L + LA QK +ELE A+ + E+EV Sbjct: 1676 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1735 Query: 782 ---------------SKAQQLAEVEVKKFKQMTE 800 K++Q E E +F+++ E Sbjct: 1736 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769 Score = 45.1 bits (105), Expect = 3e-04 Identities = 50/159 (31%), Positives = 75/159 (47%), Gaps = 8/159 (5%) Query: 648 QRTRDALQRS-VQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQ----SEAEKA 702 + T A QRS V+ + E +K +A R+E E R + R K Q EAEK Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSKLKA-RIEAENRALILRDKDNTQRFLQEEAEKM 2241 Query: 703 RKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRV 762 ++ E LS+A + + AE R E +L+ K++A A +AE + + Sbjct: 2242 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELL 2300 Query: 763 QKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEA 801 Q+ +EL AR E + AQQLAE E + F++ EA Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEA 2338 Score = 44.3 bits (103), Expect = 5e-04 Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 33/189 (17%) Query: 644 EPVDQRTRDALQRSVQLAIEITTNSQEA--AAKHEAQRLEQEARGRLERQKILDQSE--- 698 E + + R A + + +L ++ SQ A A R++ EA E+Q+ L E Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1510 Query: 699 --AEKARKELLELEA-----LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL 751 AE+A + L + E + +A+E T AEAE +++ A + + L+ L+ + + Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1569 Query: 752 AI-------------ETEAELQRVQKVRELELVYARAQLEL-------EVSKAQQLAEVE 791 A+ + EAE R + RELE +A L EV++ + LA+ E Sbjct: 1570 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1629 Query: 792 VKKFKQMTE 800 +K K+ E Sbjct: 1630 AEKQKEEAE 1638 Score = 43.5 bits (101), Expect = 9e-04 Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 15/156 (9%) Query: 647 DQRTRDALQR-SVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKE 705 ++R R+A +R LA E Q AA E +RL+ + E +++ +++E E AR+ Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE---EARRLRERAEQESARQL 2004 Query: 706 LLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKL-KAQALAIETEAELQRVQK 764 L EA + +AE +A A ++ + LQ L + Q++ + E + ++ Sbjct: 2005 QLAQEA--------AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056 Query: 765 VRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTE 800 E E AR Q E E +++++ E E ++ KQ E Sbjct: 2057 AAE-EAEEARVQAEREAAQSRRQVE-EAERLKQSAE 2090 Score = 43.5 bits (101), Expect = 9e-04 Identities = 48/170 (28%), Positives = 81/170 (47%), Gaps = 19/170 (11%) Query: 641 QSVEPVDQRTR-----DALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILD 695 + ++ V + TR + LQ+ +LA E QE + AQ+L +E +G Q+ L Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK-EQMAQQLAEETQGF---QRTL- 2336 Query: 696 QSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIET 755 EAE+ R+ + EA + + ++A+A + +A R + + KL LA + Sbjct: 2337 --EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2394 Query: 756 EA------ELQRVQKVRELE-LVYARAQLELEVSKAQQLAEVEVKKFKQM 798 + E+QR Q + E L A A+LE E K QQ A++ K ++M Sbjct: 2395 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444 Score = 41.2 bits (95), Expect = 0.004 Identities = 41/140 (29%), Positives = 67/140 (47%), Gaps = 11/140 (7%) Query: 653 ALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEA 711 AL++ QLA ++Q +A A+ EA+ L+Q + + R++ ++ R EL+ Sbjct: 1336 ALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1392 Query: 712 LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELV 771 L + E+ AKA AE +R+ E + +L+ +A E QR EL+ + Sbjct: 1393 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------TERQRGGAEGELQAL 1446 Query: 772 YARAQLELEVSKAQQLAEVE 791 ARA+ E E K Q E E Sbjct: 1447 RARAE-EAEAQKRQAQEEAE 1465 Score = 41.2 bits (95), Expect = 0.004 Identities = 47/169 (27%), Positives = 76/169 (44%), Gaps = 13/169 (7%) Query: 669 QEAAAKHEAQ------RLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 +E AA+H+A +L + + LERQK L + + R+ E+ AL + E Sbjct: 1849 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1908 Query: 723 KAEAESRAEAARIEGEGSVL---QAKLKAQALAIETEAELQRVQKVRELELVYARAQLEL 779 KAE E R E ++ QA+L+A A + AE +R ++ E E V E Sbjct: 1909 KAELELELGRIRSNAEDTLRSKEQAELEA-ARQRQLAAEEERRRREAE-ERVQKSLAAEE 1966 Query: 780 EVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLK 828 E ++ ++ A EV++ K E +R+ A Q++L Q K Sbjct: 1967 EAARQRKAALEEVERLKAKVEE--ARRLRERAEQESARQLQLAQEAAQK 2013 Score = 40.4 bits (93), Expect = 0.007 Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 14/155 (9%) Query: 648 QRTRDALQ--RSVQLAIEITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAE 700 Q R+A Q R V+ A + +++E A A+ A++L +EA R+ +Q+ Sbjct: 2067 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2126 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL----AIETE 756 + + E+E E T KA+ E R++ E + Q L + L A TE Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186 Query: 757 AELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791 A QR Q E EL R Q+E E+SK + E E Sbjct: 2187 AARQRSQV--EEELFSVRVQME-ELSKLKARIEAE 2218 Score = 39.7 bits (91), Expect = 0.013 Identities = 43/179 (24%), Positives = 84/179 (46%), Gaps = 20/179 (11%) Query: 641 QSVEPVDQRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEA 699 +++E QR + + +L + + S+ +A A+ +AQR ++A E+ + + Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2393 Query: 700 EKARK-ELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAE 758 EK + LE++ ++ +A AE E +++ E +LQ K + + ++ E Sbjct: 2394 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTVQQEQL 2452 Query: 759 LQRVQKV-------------RELELVYARAQLEL----EVSKAQQLAEVEVKKFKQMTE 800 LQ Q + RE + +A+LE EV+KAQQL E + ++ +QM + Sbjct: 2453 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511 Score = 38.1 bits (87), Expect = 0.037 Identities = 43/180 (23%), Positives = 87/180 (48%), Gaps = 23/180 (12%) Query: 662 IEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGT 721 +E + + A + E+ A+ + E ++ +++E E R +L EAL + +++ Sbjct: 1560 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1619 Query: 722 AKAEAESRAEAARIEGEGS-VLQAKLKAQALAI-ETEAELQRVQKVREL----------- 768 A+ ++ ++AEA + + E + + KA+ A+ + E Q ++K R+L Sbjct: 1620 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1679 Query: 769 --ELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIR-----DLAVAGPEMQVKL 821 EL+ RA+ E + + +QL E E+ + ++ EA + R +LA EM+V L Sbjct: 1680 EQELIRLRAETE-QGEQQRQLLEEELARLQR--EAAAATQKRQELEAELAKVRAEMEVLL 1736 Score = 35.8 bits (81), Expect = 0.18 Identities = 26/120 (21%), Positives = 56/120 (46%), Gaps = 4/120 (3%) Query: 683 EARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVL 742 E R+E ++ L + + + R+ L E+EA A A+A+++AE E + + Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366 Query: 743 QAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAI 802 + ++ + A++ + + + +Q+ EL R E E+ + AE + ++ E I Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQE----ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 46.6 bits (109), Expect = 1e-04 Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 13/152 (8%) Query: 648 QRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 Q+ LQ+++Q + + EA A A +EAR + ER EA ++R+++ Sbjct: 2196 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-------EAAQSRRQV 2248 Query: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSV---LQAKLKAQALAIETEAELQRVQ 763 E E L + E A+A+A++ AE R E E QA+ A +AE+++ + Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308 Query: 764 KVRELELVYARAQLELEVSKAQ-QLAEVEVKK 794 K E + + +AQ+E E++ + QL E + +K Sbjct: 2309 KFAE-QTLRQKAQVEQELTTLRLQLEETDHQK 2339 Score = 45.4 bits (106), Expect = 2e-04 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 28/154 (18%) Query: 669 QEAAAKHEAQRLEQEA------RGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 Q++ A+ EA++ ++EA RG+ E Q + + AE+ ELE E T Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ------ELEKQRQLAEGTAQQ 1844 Query: 723 KAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV- 781 + AE R E E Q +L + LA QK +ELE A+ + E+EV Sbjct: 1845 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1904 Query: 782 ---------------SKAQQLAEVEVKKFKQMTE 800 K++Q E E +F+++ E Sbjct: 1905 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938 Score = 45.1 bits (105), Expect = 3e-04 Identities = 50/159 (31%), Positives = 75/159 (47%), Gaps = 8/159 (5%) Query: 648 QRTRDALQRS-VQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQ----SEAEKA 702 + T A QRS V+ + E +K +A R+E E R + R K Q EAEK Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKA-RIEAENRALILRDKDNTQRFLQEEAEKM 2410 Query: 703 RKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRV 762 ++ E LS+A + + AE R E +L+ K++A A +AE + + Sbjct: 2411 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELL 2469 Query: 763 QKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEA 801 Q+ +EL AR E + AQQLAE E + F++ EA Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEA 2507 Score = 44.3 bits (103), Expect = 5e-04 Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 33/189 (17%) Query: 644 EPVDQRTRDALQRSVQLAIEITTNSQEA--AAKHEAQRLEQEARGRLERQKILDQSE--- 698 E + + R A + + +L ++ SQ A A R++ EA E+Q+ L E Sbjct: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1679 Query: 699 --AEKARKELLELEA-----LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL 751 AE+A + L + E + +A+E T AEAE +++ A + + L+ L+ + + Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1738 Query: 752 AI-------------ETEAELQRVQKVRELELVYARAQLEL-------EVSKAQQLAEVE 791 A+ + EAE R + RELE +A L EV++ + LA+ E Sbjct: 1739 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1798 Query: 792 VKKFKQMTE 800 +K K+ E Sbjct: 1799 AEKQKEEAE 1807 Score = 43.5 bits (101), Expect = 9e-04 Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 15/156 (9%) Query: 647 DQRTRDALQR-SVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKE 705 ++R R+A +R LA E Q AA E +RL+ + E +++ +++E E AR+ Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE---EARRLRERAEQESARQL 2173 Query: 706 LLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKL-KAQALAIETEAELQRVQK 764 L EA + +AE +A A ++ + LQ L + Q++ + E + ++ Sbjct: 2174 QLAQEA--------AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225 Query: 765 VRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTE 800 E E AR Q E E +++++ E E ++ KQ E Sbjct: 2226 AAE-EAEEARVQAEREAAQSRRQVE-EAERLKQSAE 2259 Score = 43.5 bits (101), Expect = 9e-04 Identities = 48/170 (28%), Positives = 81/170 (47%), Gaps = 19/170 (11%) Query: 641 QSVEPVDQRTR-----DALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILD 695 + ++ V + TR + LQ+ +LA E QE + AQ+L +E +G Q+ L Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK-EQMAQQLAEETQGF---QRTL- 2505 Query: 696 QSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIET 755 EAE+ R+ + EA + + ++A+A + +A R + + KL LA + Sbjct: 2506 --EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2563 Query: 756 EA------ELQRVQKVRELE-LVYARAQLELEVSKAQQLAEVEVKKFKQM 798 + E+QR Q + E L A A+LE E K QQ A++ K ++M Sbjct: 2564 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613 Score = 41.2 bits (95), Expect = 0.004 Identities = 41/140 (29%), Positives = 67/140 (47%), Gaps = 11/140 (7%) Query: 653 ALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEA 711 AL++ QLA ++Q +A A+ EA+ L+Q + + R++ ++ R EL+ Sbjct: 1505 ALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1561 Query: 712 LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELV 771 L + E+ AKA AE +R+ E + +L+ +A E QR EL+ + Sbjct: 1562 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------TERQRGGAEGELQAL 1615 Query: 772 YARAQLELEVSKAQQLAEVE 791 ARA+ E E K Q E E Sbjct: 1616 RARAE-EAEAQKRQAQEEAE 1634 Score = 41.2 bits (95), Expect = 0.004 Identities = 47/169 (27%), Positives = 76/169 (44%), Gaps = 13/169 (7%) Query: 669 QEAAAKHEAQ------RLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 +E AA+H+A +L + + LERQK L + + R+ E+ AL + E Sbjct: 2018 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 2077 Query: 723 KAEAESRAEAARIEGEGSVL---QAKLKAQALAIETEAELQRVQKVRELELVYARAQLEL 779 KAE E R E ++ QA+L+A A + AE +R ++ E E V E Sbjct: 2078 KAELELELGRIRSNAEDTLRSKEQAELEA-ARQRQLAAEEERRRREAE-ERVQKSLAAEE 2135 Query: 780 EVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLK 828 E ++ ++ A EV++ K E +R+ A Q++L Q K Sbjct: 2136 EAARQRKAALEEVERLKAKVEE--ARRLRERAEQESARQLQLAQEAAQK 2182 Score = 40.4 bits (93), Expect = 0.007 Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 14/155 (9%) Query: 648 QRTRDALQ--RSVQLAIEITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAE 700 Q R+A Q R V+ A + +++E A A+ A++L +EA R+ +Q+ Sbjct: 2236 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2295 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL----AIETE 756 + + E+E E T KA+ E R++ E + Q L + L A TE Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355 Query: 757 AELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791 A QR Q E EL R Q+E E+SK + E E Sbjct: 2356 AARQRSQV--EEELFSVRVQME-ELSKLKARIEAE 2387 Score = 39.7 bits (91), Expect = 0.013 Identities = 43/179 (24%), Positives = 84/179 (46%), Gaps = 20/179 (11%) Query: 641 QSVEPVDQRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEA 699 +++E QR + + +L + + S+ +A A+ +AQR ++A E+ + + Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2562 Query: 700 EKARK-ELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAE 758 EK + LE++ ++ +A AE E +++ E +LQ K + + ++ E Sbjct: 2563 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTVQQEQL 2621 Query: 759 LQRVQKV-------------RELELVYARAQLEL----EVSKAQQLAEVEVKKFKQMTE 800 LQ Q + RE + +A+LE EV+KAQQL E + ++ +QM + Sbjct: 2622 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680 Score = 38.1 bits (87), Expect = 0.037 Identities = 43/180 (23%), Positives = 87/180 (48%), Gaps = 23/180 (12%) Query: 662 IEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGT 721 +E + + A + E+ A+ + E ++ +++E E R +L EAL + +++ Sbjct: 1729 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1788 Query: 722 AKAEAESRAEAARIEGEGS-VLQAKLKAQALAI-ETEAELQRVQKVREL----------- 768 A+ ++ ++AEA + + E + + KA+ A+ + E Q ++K R+L Sbjct: 1789 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1848 Query: 769 --ELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIR-----DLAVAGPEMQVKL 821 EL+ RA+ E + + +QL E E+ + ++ EA + R +LA EM+V L Sbjct: 1849 EQELIRLRAETE-QGEQQRQLLEEELARLQR--EAAAATQKRQELEAELAKVRAEMEVLL 1905 Score = 35.8 bits (81), Expect = 0.18 Identities = 26/120 (21%), Positives = 56/120 (46%), Gaps = 4/120 (3%) Query: 683 EARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVL 742 E R+E ++ L + + + R+ L E+EA A A+A+++AE E + + Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535 Query: 743 QAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAI 802 + ++ + A++ + + + +Q+ EL R E E+ + AE + ++ E I Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQE----ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 46.6 bits (109), Expect = 1e-04 Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 13/152 (8%) Query: 648 QRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 Q+ LQ+++Q + + EA A A +EAR + ER EA ++R+++ Sbjct: 2037 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-------EAAQSRRQV 2089 Query: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSV---LQAKLKAQALAIETEAELQRVQ 763 E E L + E A+A+A++ AE R E E QA+ A +AE+++ + Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149 Query: 764 KVRELELVYARAQLELEVSKAQ-QLAEVEVKK 794 K E + + +AQ+E E++ + QL E + +K Sbjct: 2150 KFAE-QTLRQKAQVEQELTTLRLQLEETDHQK 2180 Score = 45.4 bits (106), Expect = 2e-04 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 28/154 (18%) Query: 669 QEAAAKHEAQRLEQEA------RGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 Q++ A+ EA++ ++EA RG+ E Q + + AE+ ELE E T Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ------ELEKQRQLAEGTAQQ 1685 Query: 723 KAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV- 781 + AE R E E Q +L + LA QK +ELE A+ + E+EV Sbjct: 1686 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1745 Query: 782 ---------------SKAQQLAEVEVKKFKQMTE 800 K++Q E E +F+++ E Sbjct: 1746 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779 Score = 45.1 bits (105), Expect = 3e-04 Identities = 50/159 (31%), Positives = 75/159 (47%), Gaps = 8/159 (5%) Query: 648 QRTRDALQRS-VQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQ----SEAEKA 702 + T A QRS V+ + E +K +A R+E E R + R K Q EAEK Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKA-RIEAENRALILRDKDNTQRFLQEEAEKM 2251 Query: 703 RKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRV 762 ++ E LS+A + + AE R E +L+ K++A A +AE + + Sbjct: 2252 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELL 2310 Query: 763 QKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEA 801 Q+ +EL AR E + AQQLAE E + F++ EA Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEA 2348 Score = 44.3 bits (103), Expect = 5e-04 Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 33/189 (17%) Query: 644 EPVDQRTRDALQRSVQLAIEITTNSQEA--AAKHEAQRLEQEARGRLERQKILDQSE--- 698 E + + R A + + +L ++ SQ A A R++ EA E+Q+ L E Sbjct: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1520 Query: 699 --AEKARKELLELEA-----LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL 751 AE+A + L + E + +A+E T AEAE +++ A + + L+ L+ + + Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1579 Query: 752 AI-------------ETEAELQRVQKVRELELVYARAQLEL-------EVSKAQQLAEVE 791 A+ + EAE R + RELE +A L EV++ + LA+ E Sbjct: 1580 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1639 Query: 792 VKKFKQMTE 800 +K K+ E Sbjct: 1640 AEKQKEEAE 1648 Score = 43.5 bits (101), Expect = 9e-04 Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 15/156 (9%) Query: 647 DQRTRDALQR-SVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKE 705 ++R R+A +R LA E Q AA E +RL+ + E +++ +++E E AR+ Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE---EARRLRERAEQESARQL 2014 Query: 706 LLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKL-KAQALAIETEAELQRVQK 764 L EA + +AE +A A ++ + LQ L + Q++ + E + ++ Sbjct: 2015 QLAQEA--------AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066 Query: 765 VRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTE 800 E E AR Q E E +++++ E E ++ KQ E Sbjct: 2067 AAE-EAEEARVQAEREAAQSRRQVE-EAERLKQSAE 2100 Score = 43.5 bits (101), Expect = 9e-04 Identities = 48/170 (28%), Positives = 81/170 (47%), Gaps = 19/170 (11%) Query: 641 QSVEPVDQRTR-----DALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILD 695 + ++ V + TR + LQ+ +LA E QE + AQ+L +E +G Q+ L Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK-EQMAQQLAEETQGF---QRTL- 2346 Query: 696 QSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIET 755 EAE+ R+ + EA + + ++A+A + +A R + + KL LA + Sbjct: 2347 --EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2404 Query: 756 EA------ELQRVQKVRELE-LVYARAQLELEVSKAQQLAEVEVKKFKQM 798 + E+QR Q + E L A A+LE E K QQ A++ K ++M Sbjct: 2405 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454 Score = 41.2 bits (95), Expect = 0.004 Identities = 41/140 (29%), Positives = 67/140 (47%), Gaps = 11/140 (7%) Query: 653 ALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEA 711 AL++ QLA ++Q +A A+ EA+ L+Q + + R++ ++ R EL+ Sbjct: 1346 ALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1402 Query: 712 LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELV 771 L + E+ AKA AE +R+ E + +L+ +A E QR EL+ + Sbjct: 1403 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------TERQRGGAEGELQAL 1456 Query: 772 YARAQLELEVSKAQQLAEVE 791 ARA+ E E K Q E E Sbjct: 1457 RARAE-EAEAQKRQAQEEAE 1475 Score = 41.2 bits (95), Expect = 0.004 Identities = 47/169 (27%), Positives = 76/169 (44%), Gaps = 13/169 (7%) Query: 669 QEAAAKHEAQ------RLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 +E AA+H+A +L + + LERQK L + + R+ E+ AL + E Sbjct: 1859 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1918 Query: 723 KAEAESRAEAARIEGEGSVL---QAKLKAQALAIETEAELQRVQKVRELELVYARAQLEL 779 KAE E R E ++ QA+L+A A + AE +R ++ E E V E Sbjct: 1919 KAELELELGRIRSNAEDTLRSKEQAELEA-ARQRQLAAEEERRRREAE-ERVQKSLAAEE 1976 Query: 780 EVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLK 828 E ++ ++ A EV++ K E +R+ A Q++L Q K Sbjct: 1977 EAARQRKAALEEVERLKAKVEE--ARRLRERAEQESARQLQLAQEAAQK 2023 Score = 40.4 bits (93), Expect = 0.007 Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 14/155 (9%) Query: 648 QRTRDALQ--RSVQLAIEITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAE 700 Q R+A Q R V+ A + +++E A A+ A++L +EA R+ +Q+ Sbjct: 2077 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2136 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL----AIETE 756 + + E+E E T KA+ E R++ E + Q L + L A TE Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196 Query: 757 AELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791 A QR Q E EL R Q+E E+SK + E E Sbjct: 2197 AARQRSQV--EEELFSVRVQME-ELSKLKARIEAE 2228 Score = 39.7 bits (91), Expect = 0.013 Identities = 43/179 (24%), Positives = 84/179 (46%), Gaps = 20/179 (11%) Query: 641 QSVEPVDQRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEA 699 +++E QR + + +L + + S+ +A A+ +AQR ++A E+ + + Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2403 Query: 700 EKARK-ELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAE 758 EK + LE++ ++ +A AE E +++ E +LQ K + + ++ E Sbjct: 2404 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTVQQEQL 2462 Query: 759 LQRVQKV-------------RELELVYARAQLEL----EVSKAQQLAEVEVKKFKQMTE 800 LQ Q + RE + +A+LE EV+KAQQL E + ++ +QM + Sbjct: 2463 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521 Score = 38.1 bits (87), Expect = 0.037 Identities = 43/180 (23%), Positives = 87/180 (48%), Gaps = 23/180 (12%) Query: 662 IEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGT 721 +E + + A + E+ A+ + E ++ +++E E R +L EAL + +++ Sbjct: 1570 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1629 Query: 722 AKAEAESRAEAARIEGEGS-VLQAKLKAQALAI-ETEAELQRVQKVREL----------- 768 A+ ++ ++AEA + + E + + KA+ A+ + E Q ++K R+L Sbjct: 1630 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1689 Query: 769 --ELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIR-----DLAVAGPEMQVKL 821 EL+ RA+ E + + +QL E E+ + ++ EA + R +LA EM+V L Sbjct: 1690 EQELIRLRAETE-QGEQQRQLLEEELARLQR--EAAAATQKRQELEAELAKVRAEMEVLL 1746 Score = 35.8 bits (81), Expect = 0.18 Identities = 26/120 (21%), Positives = 56/120 (46%), Gaps = 4/120 (3%) Query: 683 EARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVL 742 E R+E ++ L + + + R+ L E+EA A A+A+++AE E + + Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376 Query: 743 QAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAI 802 + ++ + A++ + + + +Q+ EL R E E+ + AE + ++ E I Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQE----ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 46.6 bits (109), Expect = 1e-04 Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 13/152 (8%) Query: 648 QRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 Q+ LQ+++Q + + EA A A +EAR + ER EA ++R+++ Sbjct: 2045 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-------EAAQSRRQV 2097 Query: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSV---LQAKLKAQALAIETEAELQRVQ 763 E E L + E A+A+A++ AE R E E QA+ A +AE+++ + Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2157 Query: 764 KVRELELVYARAQLELEVSKAQ-QLAEVEVKK 794 K E + + +AQ+E E++ + QL E + +K Sbjct: 2158 KFAE-QTLRQKAQVEQELTTLRLQLEETDHQK 2188 Score = 45.4 bits (106), Expect = 2e-04 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 28/154 (18%) Query: 669 QEAAAKHEAQRLEQEA------RGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 Q++ A+ EA++ ++EA RG+ E Q + + AE+ ELE E T Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ------ELEKQRQLAEGTAQQ 1693 Query: 723 KAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV- 781 + AE R E E Q +L + LA QK +ELE A+ + E+EV Sbjct: 1694 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1753 Query: 782 ---------------SKAQQLAEVEVKKFKQMTE 800 K++Q E E +F+++ E Sbjct: 1754 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787 Score = 45.1 bits (105), Expect = 3e-04 Identities = 50/159 (31%), Positives = 75/159 (47%), Gaps = 8/159 (5%) Query: 648 QRTRDALQRS-VQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQ----SEAEKA 702 + T A QRS V+ + E +K +A R+E E R + R K Q EAEK Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSKLKA-RIEAENRALILRDKDNTQRFLQEEAEKM 2259 Query: 703 RKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRV 762 ++ E LS+A + + AE R E +L+ K++A A +AE + + Sbjct: 2260 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELL 2318 Query: 763 QKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEA 801 Q+ +EL AR E + AQQLAE E + F++ EA Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEA 2356 Score = 44.3 bits (103), Expect = 5e-04 Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 33/189 (17%) Query: 644 EPVDQRTRDALQRSVQLAIEITTNSQEA--AAKHEAQRLEQEARGRLERQKILDQSE--- 698 E + + R A + + +L ++ SQ A A R++ EA E+Q+ L E Sbjct: 1469 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1528 Query: 699 --AEKARKELLELEA-----LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL 751 AE+A + L + E + +A+E T AEAE +++ A + + L+ L+ + + Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1587 Query: 752 AI-------------ETEAELQRVQKVRELELVYARAQLEL-------EVSKAQQLAEVE 791 A+ + EAE R + RELE +A L EV++ + LA+ E Sbjct: 1588 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1647 Query: 792 VKKFKQMTE 800 +K K+ E Sbjct: 1648 AEKQKEEAE 1656 Score = 43.5 bits (101), Expect = 9e-04 Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 15/156 (9%) Query: 647 DQRTRDALQR-SVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKE 705 ++R R+A +R LA E Q AA E +RL+ + E +++ +++E E AR+ Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE---EARRLRERAEQESARQL 2022 Query: 706 LLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKL-KAQALAIETEAELQRVQK 764 L EA + +AE +A A ++ + LQ L + Q++ + E + ++ Sbjct: 2023 QLAQEA--------AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074 Query: 765 VRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTE 800 E E AR Q E E +++++ E E ++ KQ E Sbjct: 2075 AAE-EAEEARVQAEREAAQSRRQVE-EAERLKQSAE 2108 Score = 43.5 bits (101), Expect = 9e-04 Identities = 48/170 (28%), Positives = 81/170 (47%), Gaps = 19/170 (11%) Query: 641 QSVEPVDQRTR-----DALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILD 695 + ++ V + TR + LQ+ +LA E QE + AQ+L +E +G Q+ L Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK-EQMAQQLAEETQGF---QRTL- 2354 Query: 696 QSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIET 755 EAE+ R+ + EA + + ++A+A + +A R + + KL LA + Sbjct: 2355 --EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2412 Query: 756 EA------ELQRVQKVRELE-LVYARAQLELEVSKAQQLAEVEVKKFKQM 798 + E+QR Q + E L A A+LE E K QQ A++ K ++M Sbjct: 2413 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462 Score = 41.2 bits (95), Expect = 0.004 Identities = 41/140 (29%), Positives = 67/140 (47%), Gaps = 11/140 (7%) Query: 653 ALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEA 711 AL++ QLA ++Q +A A+ EA+ L+Q + + R++ ++ R EL+ Sbjct: 1354 ALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1410 Query: 712 LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELV 771 L + E+ AKA AE +R+ E + +L+ +A E QR EL+ + Sbjct: 1411 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------TERQRGGAEGELQAL 1464 Query: 772 YARAQLELEVSKAQQLAEVE 791 ARA+ E E K Q E E Sbjct: 1465 RARAE-EAEAQKRQAQEEAE 1483 Score = 41.2 bits (95), Expect = 0.004 Identities = 47/169 (27%), Positives = 76/169 (44%), Gaps = 13/169 (7%) Query: 669 QEAAAKHEAQ------RLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 +E AA+H+A +L + + LERQK L + + R+ E+ AL + E Sbjct: 1867 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1926 Query: 723 KAEAESRAEAARIEGEGSVL---QAKLKAQALAIETEAELQRVQKVRELELVYARAQLEL 779 KAE E R E ++ QA+L+A A + AE +R ++ E E V E Sbjct: 1927 KAELELELGRIRSNAEDTLRSKEQAELEA-ARQRQLAAEEERRRREAE-ERVQKSLAAEE 1984 Query: 780 EVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLK 828 E ++ ++ A EV++ K E +R+ A Q++L Q K Sbjct: 1985 EAARQRKAALEEVERLKAKVEE--ARRLRERAEQESARQLQLAQEAAQK 2031 Score = 40.4 bits (93), Expect = 0.007 Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 14/155 (9%) Query: 648 QRTRDALQ--RSVQLAIEITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAE 700 Q R+A Q R V+ A + +++E A A+ A++L +EA R+ +Q+ Sbjct: 2085 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2144 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL----AIETE 756 + + E+E E T KA+ E R++ E + Q L + L A TE Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204 Query: 757 AELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791 A QR Q E EL R Q+E E+SK + E E Sbjct: 2205 AARQRSQV--EEELFSVRVQME-ELSKLKARIEAE 2236 Score = 39.7 bits (91), Expect = 0.013 Identities = 43/179 (24%), Positives = 84/179 (46%), Gaps = 20/179 (11%) Query: 641 QSVEPVDQRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEA 699 +++E QR + + +L + + S+ +A A+ +AQR ++A E+ + + Sbjct: 2352 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2411 Query: 700 EKARK-ELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAE 758 EK + LE++ ++ +A AE E +++ E +LQ K + + ++ E Sbjct: 2412 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTVQQEQL 2470 Query: 759 LQRVQKV-------------RELELVYARAQLEL----EVSKAQQLAEVEVKKFKQMTE 800 LQ Q + RE + +A+LE EV+KAQQL E + ++ +QM + Sbjct: 2471 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529 Score = 38.1 bits (87), Expect = 0.037 Identities = 43/180 (23%), Positives = 87/180 (48%), Gaps = 23/180 (12%) Query: 662 IEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGT 721 +E + + A + E+ A+ + E ++ +++E E R +L EAL + +++ Sbjct: 1578 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1637 Query: 722 AKAEAESRAEAARIEGEGS-VLQAKLKAQALAI-ETEAELQRVQKVREL----------- 768 A+ ++ ++AEA + + E + + KA+ A+ + E Q ++K R+L Sbjct: 1638 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1697 Query: 769 --ELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIR-----DLAVAGPEMQVKL 821 EL+ RA+ E + + +QL E E+ + ++ EA + R +LA EM+V L Sbjct: 1698 EQELIRLRAETE-QGEQQRQLLEEELARLQR--EAAAATQKRQELEAELAKVRAEMEVLL 1754 Score = 35.8 bits (81), Expect = 0.18 Identities = 26/120 (21%), Positives = 56/120 (46%), Gaps = 4/120 (3%) Query: 683 EARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVL 742 E R+E ++ L + + + R+ L E+EA A A+A+++AE E + + Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1384 Query: 743 QAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAI 802 + ++ + A++ + + + +Q+ EL R E E+ + AE + ++ E I Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQE----ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 46.6 bits (109), Expect = 1e-04 Identities = 43/152 (28%), Positives = 76/152 (50%), Gaps = 13/152 (8%) Query: 648 QRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 Q+ LQ+++Q + + EA A A +EAR + ER EA ++R+++ Sbjct: 2086 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER-------EAAQSRRQV 2138 Query: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSV---LQAKLKAQALAIETEAELQRVQ 763 E E L + E A+A+A++ AE R E E QA+ A +AE+++ + Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2198 Query: 764 KVRELELVYARAQLELEVSKAQ-QLAEVEVKK 794 K E + + +AQ+E E++ + QL E + +K Sbjct: 2199 KFAE-QTLRQKAQVEQELTTLRLQLEETDHQK 2229 Score = 45.4 bits (106), Expect = 2e-04 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 28/154 (18%) Query: 669 QEAAAKHEAQRLEQEA------RGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 Q++ A+ EA++ ++EA RG+ E Q + + AE+ ELE E T Sbjct: 1681 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ------ELEKQRQLAEGTAQQ 1734 Query: 723 KAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV- 781 + AE R E E Q +L + LA QK +ELE A+ + E+EV Sbjct: 1735 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVL 1794 Query: 782 ---------------SKAQQLAEVEVKKFKQMTE 800 K++Q E E +F+++ E Sbjct: 1795 LASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828 Score = 45.1 bits (105), Expect = 3e-04 Identities = 50/159 (31%), Positives = 75/159 (47%), Gaps = 8/159 (5%) Query: 648 QRTRDALQRS-VQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQ----SEAEKA 702 + T A QRS V+ + E +K +A R+E E R + R K Q EAEK Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKA-RIEAENRALILRDKDNTQRFLQEEAEKM 2300 Query: 703 RKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRV 762 ++ E LS+A + + AE R E +L+ K++A A +AE + + Sbjct: 2301 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE-KMLKEKMQAVQEATRLKAEAELL 2359 Query: 763 QKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEA 801 Q+ +EL AR E + AQQLAE E + F++ EA Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAE-ETQGFQRTLEA 2397 Score = 44.3 bits (103), Expect = 5e-04 Identities = 49/189 (25%), Positives = 85/189 (44%), Gaps = 33/189 (17%) Query: 644 EPVDQRTRDALQRSVQLAIEITTNSQEA--AAKHEAQRLEQEARGRLERQKILDQSE--- 698 E + + R A + + +L ++ SQ A A R++ EA E+Q+ L E Sbjct: 1510 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1569 Query: 699 --AEKARKELLELEA-----LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL 751 AE+A + L + E + +A+E T AEAE +++ A + + L+ L+ + + Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALE-TAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1628 Query: 752 AI-------------ETEAELQRVQKVRELELVYARAQLEL-------EVSKAQQLAEVE 791 A+ + EAE R + RELE +A L EV++ + LA+ E Sbjct: 1629 AVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE 1688 Query: 792 VKKFKQMTE 800 +K K+ E Sbjct: 1689 AEKQKEEAE 1697 Score = 43.5 bits (101), Expect = 9e-04 Identities = 42/156 (26%), Positives = 76/156 (48%), Gaps = 15/156 (9%) Query: 647 DQRTRDALQR-SVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKE 705 ++R R+A +R LA E Q AA E +RL+ + E +++ +++E E AR+ Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVE---EARRLRERAEQESARQL 2063 Query: 706 LLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKL-KAQALAIETEAELQRVQK 764 L EA + +AE +A A ++ + LQ L + Q++ + E + ++ Sbjct: 2064 QLAQEA--------AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115 Query: 765 VRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTE 800 E E AR Q E E +++++ E E ++ KQ E Sbjct: 2116 AAE-EAEEARVQAEREAAQSRRQVE-EAERLKQSAE 2149 Score = 43.5 bits (101), Expect = 9e-04 Identities = 48/170 (28%), Positives = 81/170 (47%), Gaps = 19/170 (11%) Query: 641 QSVEPVDQRTR-----DALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILD 695 + ++ V + TR + LQ+ +LA E QE + AQ+L +E +G Q+ L Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDK-EQMAQQLAEETQGF---QRTL- 2395 Query: 696 QSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIET 755 EAE+ R+ + EA + + ++A+A + +A R + + KL LA + Sbjct: 2396 --EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2453 Query: 756 EA------ELQRVQKVRELE-LVYARAQLELEVSKAQQLAEVEVKKFKQM 798 + E+QR Q + E L A A+LE E K QQ A++ K ++M Sbjct: 2454 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503 Score = 41.2 bits (95), Expect = 0.004 Identities = 41/140 (29%), Positives = 67/140 (47%), Gaps = 11/140 (7%) Query: 653 ALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEA 711 AL++ QLA ++Q +A A+ EA+ L+Q + + R++ ++ R EL+ Sbjct: 1395 ALEKQRQLA---EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ 1451 Query: 712 LSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELV 771 L + E+ AKA AE +R+ E + +L+ +A E QR EL+ + Sbjct: 1452 LRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEA------TERQRGGAEGELQAL 1505 Query: 772 YARAQLELEVSKAQQLAEVE 791 ARA+ E E K Q E E Sbjct: 1506 RARAE-EAEAQKRQAQEEAE 1524 Score = 41.2 bits (95), Expect = 0.004 Identities = 47/169 (27%), Positives = 76/169 (44%), Gaps = 13/169 (7%) Query: 669 QEAAAKHEAQ------RLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTA 722 +E AA+H+A +L + + LERQK L + + R+ E+ AL + E Sbjct: 1908 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1967 Query: 723 KAEAESRAEAARIEGEGSVL---QAKLKAQALAIETEAELQRVQKVRELELVYARAQLEL 779 KAE E R E ++ QA+L+A A + AE +R ++ E E V E Sbjct: 1968 KAELELELGRIRSNAEDTLRSKEQAELEA-ARQRQLAAEEERRRREAE-ERVQKSLAAEE 2025 Query: 780 EVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLK 828 E ++ ++ A EV++ K E +R+ A Q++L Q K Sbjct: 2026 EAARQRKAALEEVERLKAKVEE--ARRLRERAEQESARQLQLAQEAAQK 2072 Score = 40.4 bits (93), Expect = 0.007 Identities = 46/155 (29%), Positives = 70/155 (45%), Gaps = 14/155 (9%) Query: 648 QRTRDALQ--RSVQLAIEITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAE 700 Q R+A Q R V+ A + +++E A A+ A++L +EA R+ +Q+ Sbjct: 2126 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2185 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL----AIETE 756 + + E+E E T KA+ E R++ E + Q L + L A TE Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245 Query: 757 AELQRVQKVRELELVYARAQLELEVSKAQQLAEVE 791 A QR Q E EL R Q+E E+SK + E E Sbjct: 2246 AARQRSQV--EEELFSVRVQME-ELSKLKARIEAE 2277 Score = 39.7 bits (91), Expect = 0.013 Identities = 43/179 (24%), Positives = 84/179 (46%), Gaps = 20/179 (11%) Query: 641 QSVEPVDQRTRDALQRSVQLAIEITTNSQ-EAAAKHEAQRLEQEARGRLERQKILDQSEA 699 +++E QR + + +L + + S+ +A A+ +AQR ++A E+ + + Sbjct: 2393 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2452 Query: 700 EKARK-ELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAE 758 EK + LE++ ++ +A AE E +++ E +LQ K + + ++ E Sbjct: 2453 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSE-EMQTVQQEQL 2511 Query: 759 LQRVQKV-------------RELELVYARAQLEL----EVSKAQQLAEVEVKKFKQMTE 800 LQ Q + RE + +A+LE EV+KAQQL E + ++ +QM + Sbjct: 2512 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570 Score = 38.1 bits (87), Expect = 0.037 Identities = 43/180 (23%), Positives = 87/180 (48%), Gaps = 23/180 (12%) Query: 662 IEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGT 721 +E + + A + E+ A+ + E ++ +++E E R +L EAL + +++ Sbjct: 1619 LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1678 Query: 722 AKAEAESRAEAARIEGEGS-VLQAKLKAQALAI-ETEAELQRVQKVREL----------- 768 A+ ++ ++AEA + + E + + KA+ A+ + E Q ++K R+L Sbjct: 1679 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1738 Query: 769 --ELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIR-----DLAVAGPEMQVKL 821 EL+ RA+ E + + +QL E E+ + ++ EA + R +LA EM+V L Sbjct: 1739 EQELIRLRAETE-QGEQQRQLLEEELARLQR--EAAAATQKRQELEAELAKVRAEMEVLL 1795 Score = 35.8 bits (81), Expect = 0.18 Identities = 26/120 (21%), Positives = 56/120 (46%), Gaps = 4/120 (3%) Query: 683 EARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVL 742 E R+E ++ L + + + R+ L E+EA A A+A+++AE E + + Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1425 Query: 743 QAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAI 802 + ++ + A++ + + + +Q+ EL R E E+ + AE + ++ E I Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQE----ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481 >gi|94538362 flotillin 2 [Homo sapiens] Length = 428 Score = 45.8 bits (107), Expect = 2e-04 Identities = 40/125 (32%), Positives = 69/125 (55%), Gaps = 14/125 (11%) Query: 652 DALQRSVQLAIE----ITTNSQEAA-----AKHEAQRLEQEARGRLERQKILDQSEAEKA 702 + +QR Q+A+E + T+ + A A+ EA R++Q A G +Q +L Q+EAEK Sbjct: 260 EVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKI 319 Query: 703 RKELLELEALSMAVESTGTAKAE-AESRAEAARIEGEGSVLQAKLKA-QALAIETEAELQ 760 RK EA + +E+ G A+AE + +AEA + G+ + + L+A +A + A L Sbjct: 320 RK---IGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLT 376 Query: 761 RVQKV 765 +V ++ Sbjct: 377 KVDEI 381 Score = 33.9 bits (76), Expect = 0.69 Identities = 36/147 (24%), Positives = 62/147 (42%), Gaps = 10/147 (6%) Query: 647 DQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKEL 706 D + LQ+S + E+ + EA +E Q ++ + R E +I ++ E Sbjct: 214 DSKRAFELQKSA-FSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEA 272 Query: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVR 766 E+ + +T AEAE+ EGE K+K LA +AE ++++K+ Sbjct: 273 QEILRTDKELIATVRRPAEAEAHRIQQIAEGE------KVKQVLLA---QAEAEKIRKIG 323 Query: 767 ELELVYARAQLELEVSKAQQLAEVEVK 793 E E A + E + + AE K Sbjct: 324 EAEAAVIEAMGKAEAERMKLKAEAYQK 350 Score = 32.3 bits (72), Expect = 2.0 Identities = 34/138 (24%), Positives = 55/138 (39%), Gaps = 32/138 (23%) Query: 668 SQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALS----MAVESTGTAK 723 S+E K +L E +G E+QKI R+E +E+E + +AVE+ + Sbjct: 227 SEEVNIKTAEAQLAYELQGAREQQKI---------RQEEIEIEVVQRKKQIAVEAQEILR 277 Query: 724 AEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSK 783 + E A R EAE R+Q++ E E V + E K Sbjct: 278 TDKELIATVRR-------------------PAEAEAHRIQQIAEGEKVKQVLLAQAEAEK 318 Query: 784 AQQLAEVEVKKFKQMTEA 801 +++ E E + M +A Sbjct: 319 IRKIGEAEAAVIEAMGKA 336 >gi|191252785 centrobin, centrosomal BRCA2 interacting protein isoform alpha [Homo sapiens] Length = 903 Score = 45.8 bits (107), Expect = 2e-04 Identities = 40/138 (28%), Positives = 72/138 (52%), Gaps = 12/138 (8%) Query: 665 TTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKA 724 T QE K Q L++E++ +LER+K Q EA+ A + +L A+ + + Sbjct: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQL-----ALVQSEVRRL 415 Query: 725 EAE---SRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV 781 E E +R E ++ E S++QA+ ++Q + +E+E +Q Q+V E A+AQ E + Sbjct: 416 EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTER---LAQAQ-ESSL 471 Query: 782 SKAQQLAEVEVKKFKQMT 799 +A L E K+ + ++ Sbjct: 472 RQAASLREHHRKQLQDLS 489 >gi|80861396 centrobin, centrosomal BRCA2 interacting protein isoform beta [Homo sapiens] Length = 925 Score = 45.8 bits (107), Expect = 2e-04 Identities = 40/138 (28%), Positives = 72/138 (52%), Gaps = 12/138 (8%) Query: 665 TTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKA 724 T QE K Q L++E++ +LER+K Q EA+ A + +L A+ + + Sbjct: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQL-----ALVQSEVRRL 415 Query: 725 EAE---SRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV 781 E E +R E ++ E S++QA+ ++Q + +E+E +Q Q+V E A+AQ E + Sbjct: 416 EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTER---LAQAQ-ESSL 471 Query: 782 SKAQQLAEVEVKKFKQMT 799 +A L E K+ + ++ Sbjct: 472 RQAASLREHHRKQLQDLS 489 >gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] Length = 2400 Score = 45.1 bits (105), Expect = 3e-04 Identities = 68/284 (23%), Positives = 116/284 (40%), Gaps = 36/284 (12%) Query: 607 ETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITT 666 E EA +G A P D P+ V + P ++ SV+ A+E Sbjct: 1872 EDVEAPEAEGEAQPESEDVET-PEAEWEVQPESEGAEAPEAEKEAQPETESVE-ALETEG 1929 Query: 667 NSQ---EAAAKHEAQRLEQEARGRLERQ-KILDQSEAEK-ARKELLELEALSMAVESTGT 721 + E A EA+ QEA G+ + + ++++ EAE+ A+ E ++EAL + VE T Sbjct: 1930 EDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVE---T 1986 Query: 722 AKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV 781 +AE E++ E+ +E A E E E+Q ++ + E AQ + E Sbjct: 1987 QEAEGEAQPESEDVE---------------APEAEGEMQEAEEEAQPESDGVEAQPKSEG 2031 Query: 782 SKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINL 841 +AQ EV+ Q TE G + V PE + + ++ G + + + Sbjct: 2032 EEAQ-----EVEGETQKTE--GDAQPESDGVEAPEAEEEAQEAEGE----VQEAEGEAHP 2080 Query: 842 FNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGD 885 + E QP V + + GE + +AP+ G+ Sbjct: 2081 ESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGE 2124 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 43.9 bits (102), Expect = 7e-04 Identities = 54/211 (25%), Positives = 93/211 (44%), Gaps = 24/211 (11%) Query: 642 SVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQR--LEQEARGR------LERQKI 693 S+E +R DAL+ + E+ ++ +H+ +R LE+E GR L++ Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGE 776 Query: 694 LDQSEAEKARKELLELEALSMAVES--TGTAKAEAESRAEAARIEGEGSVLQAKLKAQAL 751 Q+E E R+EL E A ES K A R + E + A + Q + Sbjct: 777 AHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLM 836 Query: 752 AIETEAE--LQRVQKVRE--------LELVYARAQ---LELEVSKAQQLAEVEVKKFKQM 798 ++ E E Q +Q+ +E EL +R Q EL + A+ L +V+ K+ + Sbjct: 837 TLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQ 896 Query: 799 TEAIGPSTIRDLAVAGPEMQVKLLQSLGLKS 829 A ST+++ +A +V L++L K+ Sbjct: 897 KLADDLSTLQE-KMAATSKEVARLETLVRKA 926 Score = 38.1 bits (87), Expect = 0.037 Identities = 39/165 (23%), Positives = 73/165 (44%), Gaps = 19/165 (11%) Query: 648 QRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELL 707 QR + L R V+ +++ + +AQ E E + R E+QK ++ + + +L Sbjct: 642 QREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQ 701 Query: 708 E-LEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIE------------ 754 E L+AL +++ T + E + RA A E + + + K + ++L + Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER 761 Query: 755 -----TEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKK 794 EA LQ++ + + E R +L E AQ AE E ++ Sbjct: 762 AGRKGLEARLQQLGEAHQAETEVLRREL-AEAMAAQHTAESECEQ 805 Score = 36.6 bits (83), Expect = 0.11 Identities = 46/134 (34%), Positives = 62/134 (46%), Gaps = 15/134 (11%) Query: 672 AAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAE 731 AA E+Q +QE RG+ ER+ E +A+ +L AL A A+AE E R + Sbjct: 986 AALMESQGQQQEERGQQEREVARLTQERGRAQADL----ALEKA------ARAELEMRLQ 1035 Query: 732 AARIEG--EGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAE 789 A E E + LQ L A AL E E + Q + K+R LE + EL +QL E Sbjct: 1036 NALNEQRVEFATLQEAL-AHALT-EKEGKDQELAKLRGLEAAQIKELEELR-QTVKQLKE 1092 Query: 790 VEVKKFKQMTEAIG 803 KK K+ G Sbjct: 1093 QLAKKEKEHASGSG 1106 Score = 34.7 bits (78), Expect = 0.41 Identities = 53/222 (23%), Positives = 96/222 (43%), Gaps = 21/222 (9%) Query: 668 SQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEA-LSMAVESTGTAKAEA 726 S++ A +A +++Q+ ++ Q Q EA++ + +L EL+A LS ++ K + Sbjct: 1555 SKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQM 1614 Query: 727 E-SRAEAARIEGEGSVLQAKLKA----QALAIETEAELQRV-QKVRELELVYARAQLELE 780 E ++ + + LQ +L++ Q E AE +R+ ++++ L A+ Sbjct: 1615 EKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCR 1674 Query: 781 VSKAQ-QLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKS-TLITDGSTP 838 AQ + E +V Q +G + A+ E Q K L + S L + TP Sbjct: 1675 HLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTP 1734 Query: 839 INLFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAP 880 +++ + P QP G V PGE SP S + P Sbjct: 1735 LSITSKL-------PRTQPDGTSV-----PGEPASPISQRLP 1764 Score = 32.7 bits (73), Expect = 1.5 Identities = 45/188 (23%), Positives = 86/188 (45%), Gaps = 26/188 (13%) Query: 640 VQSVEPVDQRTRDALQRSVQ--LAIEITTNSQ------EAAA---KHEAQRLEQEARGRL 688 +Q + Q + L+R + +A + T S+ E AA ++E + E+ G + Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830 Query: 689 ERQKILD-QSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLK 747 +++++ + E EKAR+EL E + +ES S + +R + E + L A L Sbjct: 831 FQEQLMTLKEECEKARQELQEAKEKVAGIES--------HSELQISRQQNELAELHANL- 881 Query: 748 AQALAIETEAELQRVQKVRELELVYAR-AQLELEVSKAQQLAEVEVKKFKQMTEAIGPST 806 A+AL E E++ + +L + + A EV++ + L V+K + E Sbjct: 882 ARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL----VRKAGEQQETASREL 937 Query: 807 IRDLAVAG 814 +++ A AG Sbjct: 938 VKEPARAG 945 >gi|157042792 coiled-coil domain containing 64B [Homo sapiens] Length = 508 Score = 43.9 bits (102), Expect = 7e-04 Identities = 50/189 (26%), Positives = 90/189 (47%), Gaps = 27/189 (14%) Query: 661 AIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQ------------SEAEKARKEL-L 707 A+E+ + + A+ QR EQ+ GR ER + L + ++A + +EL Sbjct: 118 AVELEGDVEALRAQLGEQRSEQQDSGR-ERARALSELSEQNLRLSQQLAQASQTEQELQR 176 Query: 708 ELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAK---LKAQALAIETEAEL--QRV 762 EL+AL ++ A AE +R E+ ++GE +LQ++ L+AQ + E E R+ Sbjct: 177 ELDALRGQCQAQALAGAELRTRLES--LQGENQMLQSRRQDLEAQIRGLREEVEKGEGRL 234 Query: 763 QKVRELELVYARAQLE--LEVSKAQQLAEVEVKKFKQMTEAIG----PSTIRDLAVAGPE 816 Q E L+ R + E LE+ +A+ A + +++ + S ++D V+ Sbjct: 235 QTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAAS 294 Query: 817 MQVKLLQSL 825 +Q +L SL Sbjct: 295 LQSELAHSL 303 >gi|93102364 SWAP-70 protein [Homo sapiens] Length = 585 Score = 43.5 bits (101), Expect = 9e-04 Identities = 34/132 (25%), Positives = 64/132 (48%), Gaps = 18/132 (13%) Query: 682 QEARGRLERQKILDQSEAEKARKELL--------ELEALSMAVESTGTAKAEAESRAEAA 733 ++ R L ++++ +Q E E+ KEL ELEA+ +E + AE E + Sbjct: 320 RQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQT 379 Query: 734 RIEGEG---------SVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKA 784 ++E + +++ +++ Q +E E Q +Q+VRELE +Y + Q LE + Sbjct: 380 QVELQARFSTELEREKLIRQQMEEQVAQKSSELE-QYLQRVRELEDMYLKLQEALEDERQ 438 Query: 785 QQLAEVEVKKFK 796 + E V+K + Sbjct: 439 ARQDEETVRKLQ 450 Score = 41.2 bits (95), Expect = 0.004 Identities = 63/238 (26%), Positives = 109/238 (45%), Gaps = 30/238 (12%) Query: 623 RDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQ 682 R + + Q L ++Q+ Q+ +A+++ ++ E + + E K ++E Sbjct: 327 RKKQLAEQEELERQMKELQAANESKQQELEAVRKKLE---EAASRAAEEEKKRLQTQVEL 383 Query: 683 EAR--GRLERQKILDQSEAEKARKELLELE--------------ALSMAVESTGTAKAEA 726 +AR LER+K++ Q E+ ++ ELE L A+E A+ + Sbjct: 384 QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDE 443 Query: 727 ES-RAEAARIEGEGSVLQAKLK----AQALAIE-TEAELQRVQKVRELE---LVYARAQL 777 E+ R AR+ E S +A+L+ Q AI+ TEAE Q ++ R L+ L A QL Sbjct: 444 ETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQL 503 Query: 778 E-LEVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITD 834 E LE+ + Q L + E K K++ A + VA E ++L++ LIT+ Sbjct: 504 EQLELERKQALEQYEEVK-KKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITN 560 >gi|154354979 myosin X [Homo sapiens] Length = 2058 Score = 43.5 bits (101), Expect = 9e-04 Identities = 48/158 (30%), Positives = 78/158 (49%), Gaps = 11/158 (6%) Query: 669 QEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAES 728 +E K E + E+E R R E + Q E + ++EL L+ E T + + E+ Sbjct: 826 EEEKKKREEEERERE-RERREAELRAQQEEETRKQQELEALQKSQKEAELTRELEKQKEN 884 Query: 729 RA--EAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQ 786 + E R+E E LQ + Q L++ TEA LQ++Q+ R+ EL +LE E +A Q Sbjct: 885 KQVEEILRLEKEIEDLQRMKEQQELSL-TEASLQKLQERRDQEL----RRLEEEACRAAQ 939 Query: 787 LAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQS 824 +E F ++ E + + R L+V G E +L +S Sbjct: 940 -EFLESLNFDEIDECV-RNIERSLSV-GSEFSSELAES 974 >gi|115648142 centrosomal protein 164kDa [Homo sapiens] Length = 1460 Score = 42.7 bits (99), Expect = 0.001 Identities = 40/160 (25%), Positives = 81/160 (50%), Gaps = 9/160 (5%) Query: 641 QSVEPVDQRTRDA-LQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEA 699 +++E + R R+ QR L ++ +++Q A + R EQEA + R+++ Q +A Sbjct: 653 KAIEEEEARMREEESQRLSWLRAQVQSSTQ---ADEDQIRAEQEASLQKLREELESQQKA 709 Query: 700 EKA---RKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETE 756 E+A +K LE L +E++ ++ A + A+ ++ L+ + K +E E Sbjct: 710 ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKE 769 Query: 757 --AELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKK 794 AEL+R+ E + + L+ ++ +AQQ E +++K Sbjct: 770 HSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQK 809 Score = 37.0 bits (84), Expect = 0.082 Identities = 35/163 (21%), Positives = 67/163 (41%), Gaps = 1/163 (0%) Query: 641 QSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLER-QKILDQSEA 699 Q +E + ++ Q +Q E +E Q+ EQ ER QK +++ EA Sbjct: 601 QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660 Query: 700 EKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAEL 759 +E L L V+S+ A + + A ++ L+++ KA+ ++E + Sbjct: 661 RMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQ 720 Query: 760 QRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAI 802 Q E+E Q L +K + L ++ + + EA+ Sbjct: 721 MLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAV 763 Score = 35.8 bits (81), Expect = 0.18 Identities = 45/188 (23%), Positives = 90/188 (47%), Gaps = 23/188 (12%) Query: 623 RDQAVFPQNGLVVS-----SVDVQSVEPV---DQRTRDALQRSVQLAIEITTNSQEAAAK 674 +++A P+ + VS S +V+S EPV +Q + AL+ + ++ Q + Sbjct: 553 QEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLE 612 Query: 675 HEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAAR 734 + ++++Q R+K+ + E +E+L L S+ + + E AR Sbjct: 613 SKQEKMQQL------REKLCQEEE-----EEILRLHQQKEQSLSSLRERLQKAIEEEEAR 661 Query: 735 IEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKK 794 + E S + L+AQ + T+A+ +++ +E L R +LE + KA++ A +E +K Sbjct: 662 MREEESQRLSWLRAQVQS-STQADEDQIRAEQEASLQKLREELESQ-QKAER-ASLE-QK 717 Query: 795 FKQMTEAI 802 +QM E + Sbjct: 718 NRQMLEQL 725 Score = 33.1 bits (74), Expect = 1.2 Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 7/144 (4%) Query: 643 VEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLE--RQKILDQSEAE 700 V+ Q D ++ + +++ E+ K E LEQ+ R LE +++I ++E Sbjct: 677 VQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSE 736 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAE---AARIEGEGSVLQAKLKAQALAIETEA 757 +A + +AL E + EA + E +A +E S L+AK + +++ + Sbjct: 737 QAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKK- 795 Query: 758 ELQRVQKVRELELVYARAQLELEV 781 +Q Q+ E +L Q+E V Sbjct: 796 -IQEAQQKEEAQLQKCLGQVEHRV 818 Score = 33.1 bits (74), Expect = 1.2 Identities = 41/190 (21%), Positives = 74/190 (38%), Gaps = 16/190 (8%) Query: 641 QSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAE 700 Q VE +R D ++ Q + EA + + L G LER + + E E Sbjct: 841 QEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELE 900 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQ 760 R+E +E E E + + ++ E K + L ++ E + Sbjct: 901 TVRQE------QHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARR 954 Query: 761 RVQKVRELELVYARAQLELEVSKAQQLAEVE------VKKFKQMTEAIGPSTIRDLAVAG 814 Q++ +++ A + E + QQL E + ++ +Q+ E + R L + Sbjct: 955 EKQQLLDVQRQVA-LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKL-- 1011 Query: 815 PEMQVKLLQS 824 E QV LLQ+ Sbjct: 1012 -ESQVDLLQA 1020 >gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] Length = 2017 Score = 42.7 bits (99), Expect = 0.001 Identities = 40/137 (29%), Positives = 68/137 (49%), Gaps = 10/137 (7%) Query: 670 EAAAKHEAQRLEQEARGRLER----QKILDQSEAEK--ARKELLELEALSMAVEST--GT 721 EAAA + Q+L+ E R ER Q+ L Q EAEK + L LE +A+ T Sbjct: 1826 EAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKV 1885 Query: 722 AKAEAESRAEAARIEGEGSVLQAKLKAQALAI-ETEAELQRVQ-KVRELELVYARAQLEL 779 + + S + R+ E L L L + E + ++Q+++ +V LE ++ AQLE+ Sbjct: 1886 EREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEV 1945 Query: 780 EVSKAQQLAEVEVKKFK 796 + + Q + EV++ + Sbjct: 1946 DAQQQQLELQQEVERLR 1962 Score = 42.0 bits (97), Expect = 0.003 Identities = 68/258 (26%), Positives = 103/258 (39%), Gaps = 56/258 (21%) Query: 619 LPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQ 678 LP R + Q L S + E ++ R QR V+ A+E +EA AK A Sbjct: 822 LPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE-ALERAAREKEALAKEHAG 880 Query: 679 RLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGE 738 Q E + + +E+A + LE EAL ++ A+ E+R E EG+ Sbjct: 881 LAVQLVAAEREGRTL-----SEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ 935 Query: 739 GSVL-----------------------------------QAKLKAQALAIET----EAEL 759 +L QA+ +AQA E E +L Sbjct: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDL 995 Query: 760 QRVQKVREL---ELVYARAQLELEVSKAQQ--LAEVEVKKFKQMTEAIGPSTIRD--LAV 812 QR+Q+ +E EL RAQL+ ++ + Q+ LA +E +K + E RD L + Sbjct: 996 QRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL 1055 Query: 813 AGPEMQVKLLQSLGLKST 830 A E Q Q+L LK + Sbjct: 1056 AESEKQ----QALSLKES 1069 Score = 35.0 bits (79), Expect = 0.31 Identities = 51/164 (31%), Positives = 80/164 (48%), Gaps = 35/164 (21%) Query: 653 ALQRSVQLAIEITTNSQEAAAKHEA-----QRLEQE----------ARGRLERQ-KILDQ 696 +LQ + Q A E+ ++ A E RLE+E R LER + L+Q Sbjct: 611 SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQ 670 Query: 697 SEAEKA--RKELLEL-EALSMA------VESTGTAKAEAESRAEAARIEGEGSVLQAKLK 747 E +++ KEL+E+ EALS A +++ AEA ++AEA R+E E S+ KL+ Sbjct: 671 LEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSM--TKLR 728 Query: 748 AQALAIETEAELQRVQKVRE------LELVYARAQLELEVSKAQ 785 A+ +++ L ++ + E L+L AQLE E S Q Sbjct: 729 AEEASLQD--SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQ 770 Score = 34.3 bits (77), Expect = 0.53 Identities = 58/250 (23%), Positives = 102/250 (40%), Gaps = 36/250 (14%) Query: 615 DGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAK 674 +G AL ++ GL + Q +D+ Q+ VQ E + +E A Sbjct: 933 EGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM--AQKLVQAEREAQASLREQRAA 990 Query: 675 HEA--QRLEQEARG---RLERQKILDQSEAEKARKELL-----ELEALSMAVEST----- 719 HE QRL++E LE ++ QS+ ++ ++ELL E E LS + + Sbjct: 991 HEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERD 1050 Query: 720 -GTAKAEAESRAEAARIEGEGSVLQAKL-----KAQALAIETEAELQRVQKVRELE---- 769 G AE+E + + E E + L KL +++E E + + Q +E + Sbjct: 1051 EGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTV 1110 Query: 770 --LVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPE---MQVKLLQS 824 L L + +A EV++ ++ +G RD + E Q++LL+ Sbjct: 1111 NALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQ--RDSCLREAEELRTQLRLLED 1168 Query: 825 L--GLKSTLI 832 GL+ L+ Sbjct: 1169 ARDGLRRELL 1178 Score = 32.7 bits (73), Expect = 1.5 Identities = 32/140 (22%), Positives = 67/140 (47%), Gaps = 10/140 (7%) Query: 648 QRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELL 707 ++ R AL+R++ S E + A++ GRL+R + E +A++++ Sbjct: 1872 EKDRVALRRTLDKVEREKLRSHEDTVRLSAEK------GRLDRTLTGAELELAEAQRQIQ 1925 Query: 708 ELEALSMAVE-STGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVR 766 +LEA + +E S A+ E +++ + ++ E L++ +E R Q+VR Sbjct: 1926 QLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHR-QRVR 1984 Query: 767 ELE--LVYARAQLELEVSKA 784 LE + + QL+ E+ ++ Sbjct: 1985 GLEEQVSTLKGQLQQELRRS 2004 Score = 32.0 bits (71), Expect = 2.6 Identities = 44/145 (30%), Positives = 73/145 (50%), Gaps = 12/145 (8%) Query: 655 QRSVQL---AIEITTNSQEAAAKHEAQRLEQEARG-RLERQKILDQSEAEKARKELLELE 710 QR VQ A E+ + + A H Q +Q+A R ER+K+ E + +++ LE E Sbjct: 588 QREVQRLRSANELLSREKSNLA-HSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE-E 645 Query: 711 ALSMAVESTGTAKAEAE-SRAEAARIEGEGSVLQAKL--KAQALAIET-EAELQRVQKVR 766 AV+ + E E S + ++EG+ SVL +L +AL+ T + ++ + +K Sbjct: 646 EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705 Query: 767 ELE-LVYARA-QLELEVSKAQQLAE 789 E L A A ++ELE+S + AE Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAE 730 Score = 31.2 bits (69), Expect = 4.5 Identities = 56/231 (24%), Positives = 85/231 (36%), Gaps = 37/231 (16%) Query: 651 RDALQRSVQLAIEITTNSQEAAAKHEAQRL-EQEARGRLERQKILDQSEAEKARKELLEL 709 RD LQ +LA + RL E A LE+Q +L E+ R ++L Sbjct: 319 RDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLRE 378 Query: 710 EALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELE 769 + L+ + KA+ +R E + +L+ Q L + + +K+ LE Sbjct: 379 KDLAQQQMQSDLDKADLSARVT------ELGLAVKRLEKQNLE-KDQVNKDLTEKLEALE 431 Query: 770 LVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKS 829 + + Q LE + L + T+RDLA A +Q G + Sbjct: 432 SLRLQEQAALETEDGEGLQQ----------------TLRDLAQAVLSDSESGVQLSGSER 475 Query: 830 TLITDGSTPINLFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAP 880 T D S + GL G P RR SPG G SP+ +P Sbjct: 476 T--ADASN-----GSLRGLSGQRTPSPP--RR----SSPGRGRSPRRGPSP 513 Score = 30.8 bits (68), Expect = 5.9 Identities = 38/157 (24%), Positives = 70/157 (44%), Gaps = 15/157 (9%) Query: 650 TRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQE--------ARGRLERQKILDQSEAEK 701 TR+ Q + + T + + + E Q L+QE A+ R ER ++ + A Sbjct: 56 TRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVS 115 Query: 702 ARKE-LLELEALSMAV-ESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAEL 759 R E L LE + E G + E R + ++ E + + KL+A + +A+L Sbjct: 116 ERLEQALRLEPGELETQEPRGLVRQSVELRRQ---LQEEQASYRRKLQAYQEGQQRQAQL 172 Query: 760 QRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFK 796 VQ+++ L Y + ELE ++ E+E ++ + Sbjct: 173 --VQRLQGKILQYKKRCSELEQQLLERSGELEQQRLR 207 >gi|4504063 golgin 97 [Homo sapiens] Length = 767 Score = 42.7 bits (99), Expect = 0.001 Identities = 50/183 (27%), Positives = 88/183 (48%), Gaps = 19/183 (10%) Query: 648 QRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQE------ARGRLERQKILDQSEAEK 701 +RT+ AL+ + +A+E T + + A+ ++LEQE R ER Q E +K Sbjct: 410 ERTQ-ALEAQI-VALERTRAADQTTAEQGMRQLEQENAALKECRNEYERSLQNHQFELKK 467 Query: 702 ARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKL--KAQALAIETEAEL 759 ++E + E +S+A+ A+A E R + + + + L A + K Q L +TE L Sbjct: 468 LKEEWSQREIVSVAM-----AQALEEVRKQREEFQQQAANLTAIIDEKEQNLREKTEVLL 522 Query: 760 QRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQV 819 Q+ Q++ +LE + A L++ Q AE+E + + EA + DL +Q Sbjct: 523 QKEQEILQLERGHNSALLQIH----QLQAELEALRTLKAEEAAVVAEQEDLLRLRGPLQA 578 Query: 820 KLL 822 + L Sbjct: 579 EAL 581 >gi|31982906 cingulin-like 1 [Homo sapiens] Length = 1302 Score = 42.7 bits (99), Expect = 0.001 Identities = 58/208 (27%), Positives = 89/208 (42%), Gaps = 43/208 (20%) Query: 654 LQRSVQLAIEITTNSQEAAAKHEA--QRLEQEARGRLER----QKILDQSEAEKARKELL 707 LQR +QL ++ N +E + A + L + ++E Q+ L++SE E RK L Sbjct: 626 LQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGE-LRKNLE 684 Query: 708 ELEALSMAVESTGT-----------------AKAEAESRAEAARIEGEGSVLQAKLKAQA 750 EL + M E T + +E R + A IE +LQAK Q Sbjct: 685 ELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIE---ELLQAKQDLQD 741 Query: 751 LAIETEAELQRVQKVRELELVYARAQLELEVS-------KAQQLAEVEVKKFKQMTEAI- 802 L I E + ++K RE EL + L+ EVS K ++ + E++ ++ E Sbjct: 742 LLIAKEEQEDLLRK-RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEAT 800 Query: 803 -------GPSTIRDLAVAGPEMQVKLLQ 823 S + AG EM+VKLLQ Sbjct: 801 KNVEVLASRSNTSEQDQAGTEMRVKLLQ 828 >gi|4505101 microtubule-associated protein 7 [Homo sapiens] Length = 749 Score = 42.7 bits (99), Expect = 0.001 Identities = 42/145 (28%), Positives = 65/145 (44%), Gaps = 6/145 (4%) Query: 665 TTNSQEAAAK-HEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAK 723 TT+ +EA E +RL +E R + ER++ +Q E E+ ++E E E T + Sbjct: 473 TTDPEEATRLLAEKRRLAREQREKEERER-REQEELERQKRE----ELAQRVAEERTTRR 527 Query: 724 AEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSK 783 E R EA + + LQ + + +AL EAE + QK E + ++ E K Sbjct: 528 EEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREK 587 Query: 784 AQQLAEVEVKKFKQMTEAIGPSTIR 808 Q E E + K+ E I T R Sbjct: 588 HFQREEQERLERKKRLEEIMKRTRR 612 Score = 31.6 bits (70), Expect = 3.4 Identities = 23/96 (23%), Positives = 50/96 (52%), Gaps = 5/96 (5%) Query: 644 EPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRL---EQEARGRLERQKILDQSEAE 700 E ++++ R+ L + V A E TT +E + + EA++ E++ + + E + + ++ EAE Sbjct: 505 EELERQKREELAQRV--AEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAE 562 Query: 701 KARKELLELEALSMAVESTGTAKAEAESRAEAARIE 736 +A+++ E + E + + R E R+E Sbjct: 563 RAQRQKEEEARVREEAERVRQEREKHFQREEQERLE 598 >gi|87298937 centrosomal protein 110kDa [Homo sapiens] Length = 2325 Score = 42.7 bits (99), Expect = 0.001 Identities = 36/130 (27%), Positives = 63/130 (48%), Gaps = 23/130 (17%) Query: 665 TTNSQEAAAKHEAQRLEQEARGRLERQKILDQS---------EAEKARKELLELEALSMA 715 T Q A++E ++L E L+R ++Q +AE RKEL ELE+ Sbjct: 627 TIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELES---- 682 Query: 716 VESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQ-----ALAIETEAELQRVQKVRELEL 770 + + E A + +G+ S +A+L+A+ A A + + EL++V ++ +LE Sbjct: 683 -----ALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQ 737 Query: 771 VYARAQLELE 780 +A+LE E Sbjct: 738 SALQAELEKE 747 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 42.4 bits (98), Expect = 0.002 Identities = 47/170 (27%), Positives = 81/170 (47%), Gaps = 17/170 (10%) Query: 674 KHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAA 733 KHEA + E R R E ++ + E EK R++L +ST + AE +A+ A Sbjct: 1024 KHEAMITDLEERLRREEKQ---RQELEKTRRKL--------EGDSTDLSDQIAELQAQIA 1072 Query: 734 RIEGEGSVLQAKLKAQALAIETEAELQRV--QKVRELELVYARAQLELEVSKA-QQLAEV 790 ++ + + + +L+A +E EA + + +K+RELE + Q +LE +A + AE Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK 1132 Query: 791 EVKKFKQMTEAIGP--STIRDLAVAGPEMQVKLLQSLG-LKSTLITDGST 837 + + + EA+ D A E++ K Q + LK TL + T Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT 1182 Score = 31.2 bits (69), Expect = 4.5 Identities = 38/170 (22%), Positives = 75/170 (44%), Gaps = 24/170 (14%) Query: 650 TRDALQRSVQLAIE-ITTNSQEAAAKHEA-----QRLEQEARGRL-----ERQKILDQSE 698 T + ++R +Q +E ++ +E A ++ RL+QE L +RQ + + Sbjct: 1382 TAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441 Query: 699 AEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAE 758 +K +LL E A + +AEAE+R + + L+ A+E +AE Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEE-------AMEQKAE 1494 Query: 759 LQRVQKVRELELVYARAQLE------LEVSKAQQLAEVEVKKFKQMTEAI 802 L+R+ K E+ + + E+ K+++ E +V++ K E + Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544 >gi|35038601 spindle assembly abnormal protein 6 [Homo sapiens] Length = 657 Score = 42.0 bits (97), Expect = 0.003 Identities = 41/153 (26%), Positives = 72/153 (47%), Gaps = 16/153 (10%) Query: 659 QLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVES 718 QL ++ QE K + +EA ++ QK++ + EK + +L +LEA ++S Sbjct: 319 QLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVVLEENGEKNQVQLGKLEA---TIKS 375 Query: 719 TGTAKAEAESRAEAARIEGEGSVLQAKLK--------AQALAIETEAELQRVQKVRELEL 770 +A + +++G+ L KLK + L E E +LQ+ QK EL+ Sbjct: 376 LSAELLKANEIIK--KLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQK--ELQD 431 Query: 771 VYARAQL-ELEVSKAQQLAEVEVKKFKQMTEAI 802 V ++ E EV K Q+ E VKK ++ + + Sbjct: 432 VGQSLRIKEQEVCKLQEQLEATVKKLEESKQLL 464 >gi|88196790 coiled-coil domain containing 88 [Homo sapiens] Length = 1476 Score = 42.0 bits (97), Expect = 0.003 Identities = 50/185 (27%), Positives = 86/185 (46%), Gaps = 20/185 (10%) Query: 649 RTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQ--KILDQSEAEKARKEL 706 R R+A++ + Q E+ + SQE A EA R + ER+ ++ QSEA + R ++ Sbjct: 792 RLREAVEAAGQ---ELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQV 848 Query: 707 LELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVR 766 LE E E+ + + +AE + G L A+L+ +E +A L+R + +R Sbjct: 849 LESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELE-QAALERQEFLR 907 Query: 767 ELELVYARAQ-----LELEV-----SKAQQLAEVEVKKFKQMTEAI----GPSTIRDLAV 812 E E + R Q LE E+ SK + L E++ + + E GP+ + Sbjct: 908 EKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKR 967 Query: 813 AGPEM 817 A P++ Sbjct: 968 AEPQL 972 Score = 36.6 bits (83), Expect = 0.11 Identities = 41/166 (24%), Positives = 72/166 (43%), Gaps = 19/166 (11%) Query: 673 AKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEA 732 A+ EA R E+ A+ R + + + D+ EA+ + E EA ++ E +AEAE+ EA Sbjct: 725 AEQEALR-EEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREA 783 Query: 733 -----------ARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEV 781 +E G L++ + + +E A R ++ E E RAQ E Sbjct: 784 EAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAE 843 Query: 782 SKAQQLAE------VEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKL 821 + Q L E ++ ++ EA+ + + V G E+ +L Sbjct: 844 ERMQVLESEGRQHLEEAERERREKEAL-QAELEKAVVRGKELGARL 888 >gi|5031699 flotillin 1 [Homo sapiens] Length = 427 Score = 41.6 bits (96), Expect = 0.003 Identities = 53/232 (22%), Positives = 95/232 (40%), Gaps = 34/232 (14%) Query: 582 AVASVTFDDFHKN-----------SARIIRTAVFGFETSEAKGPDGMALPRPRDQAVFPQ 630 +V S T D H + +A++ + A G +EAK G+ + + + V Q Sbjct: 145 SVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIG--EAEAKRDAGIREAKAKQEKVSAQ 202 Query: 631 NGLVVSSVDVQ----------SVEPVDQRTRDALQRSVQLAI---EITTNSQEAAAKHEA 677 + Q +E +R + L +Q+A +I + A Sbjct: 203 YLSEIEMAKAQRDYELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERA 262 Query: 678 QRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEG 737 Q++ + + R+K L+ + A E +LE L+ A +S +AEAE+ + R E Sbjct: 263 QQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRGEA 322 Query: 738 EGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAE 789 E + A+ +A+A Q +K +L AQL++ + K Q+AE Sbjct: 323 EAFAIGARARAEA--------EQMAKKAEAFQLYQEAAQLDMLLEKLPQVAE 366 Score = 31.6 bits (70), Expect = 3.4 Identities = 40/183 (21%), Positives = 79/183 (43%), Gaps = 25/183 (13%) Query: 632 GLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQ 691 G+ V S ++ + DQ +L ++ ++ EA AK +A E +A+ Sbjct: 143 GISVVSYTLKDIHD-DQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSA 201 Query: 692 KILDQSEAEKARKELLELEALSMAVE-STGTAKAEAESRAEAAR----IEGEGSVLQAKL 746 + L + E KA+++ EL+ + +E +T A+A+ + + A+ IE + +Q Sbjct: 202 QYLSEIEMAKAQRDY-ELKKAAYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVE 260 Query: 747 KAQALAIE------------------TEAELQRVQKVRELELVYARAQLELEVSKAQQLA 788 +AQ +A++ EAE +++++ E E Q E E + + Sbjct: 261 RAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAEAEKSQLIMQAEAEAASVRMRG 320 Query: 789 EVE 791 E E Sbjct: 321 EAE 323 >gi|4505257 moesin [Homo sapiens] Length = 577 Score = 41.6 bits (96), Expect = 0.003 Identities = 38/139 (27%), Positives = 68/139 (48%), Gaps = 8/139 (5%) Query: 648 QRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARG-RLERQKILDQSEAEKARKEL 706 ++ ++ ++R + +E +E K + + EQ R LE+++ QSEAEK KE Sbjct: 334 EKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKER 393 Query: 707 LELEALSMAV--ESTGTAKAEAESRAEAARIEGEGSVLQ-AKLKAQALAIETEAELQRVQ 763 E E A+ S K + + E A + S L+ A+ K ++ A+E + + Q VQ Sbjct: 394 QEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQ 453 Query: 764 KVRELELVYARAQLELEVS 782 + +L RA+L+ +S Sbjct: 454 E----DLEKTRAELKTAMS 468 Score = 38.9 bits (89), Expect = 0.022 Identities = 43/161 (26%), Positives = 87/161 (54%), Gaps = 15/161 (9%) Query: 637 SVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQ 696 +++VQ ++ Q + Q+ ++ A+ + A+ E +++E+E +ER K +++ Sbjct: 299 TIEVQQMKA--QAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEE 356 Query: 697 SEAEKARKELLELEALSMAVE-STGTAKAEAESRAEAAR--IEGEGSVLQA----KLKAQ 749 + +KA++EL E ++ +E A++EAE A+ + E + ++LQA K + Sbjct: 357 -QTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQE 415 Query: 750 ALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEV 790 LA+E AEL ++ +LE+ AR + E E + QQ A++ Sbjct: 416 QLALEM-AEL--TARISQLEM--ARQKKESEAVEWQQKAQM 451 >gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo sapiens] Length = 551 Score = 41.6 bits (96), Expect = 0.003 Identities = 42/177 (23%), Positives = 77/177 (43%), Gaps = 25/177 (14%) Query: 646 VDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARK- 704 +DQ Q+S+Q E+ +E + Q +EQ + + ER + +Q E EK + Sbjct: 228 LDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQREQEKEQML 287 Query: 705 ELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQ--------------- 749 E +E + + + + +AE RI E +A+L AQ Sbjct: 288 EYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMVMEFTKKK 347 Query: 750 -ALAIETEAELQRVQKVRELELVYARA--------QLELEVSKAQQLAEVEVKKFKQ 797 A E EAE +R+++ +E E+ RA Q E + +A++ EV +++++ Sbjct: 348 MAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQDALRAKRNQEVADREWRR 404 Score = 30.8 bits (68), Expect = 5.9 Identities = 38/143 (26%), Positives = 64/143 (44%), Gaps = 18/143 (12%) Query: 669 QEAAAKHEAQRLEQEAR--GRLERQKILDQSEAE-KARKELLELEALSMAVESTGTAKAE 725 +E A+ +A + E+EA + R+KI+ Q E K+L +LE + AK Sbjct: 122 EELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVWNNNKKLSDLEEV---------AKER 172 Query: 726 AES---RAEAARIEGEGSVLQAK---LKAQALAIETEAELQRVQKVRELELVYARAQLEL 779 A++ RA R+E E + L A+ AI L++ Q +EL+ R + Sbjct: 173 AQNLLQRANKLRMEQEEELKDMSKIILNAKCHAIRDAQILEKQQIQKELDTEEKRLDQMM 232 Query: 780 EVSKAQQLAEVEVKKFKQMTEAI 802 EV + + + E + K+ E I Sbjct: 233 EVERQKSIQRQEELERKRREERI 255 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.134 0.382 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 33,893,811 Number of Sequences: 37866 Number of extensions: 1587883 Number of successful extensions: 6724 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 21 Number of HSP's successfully gapped in prelim test: 289 Number of HSP's that attempted gapping in prelim test: 5863 Number of HSP's gapped (non-prelim): 945 length of query: 893 length of database: 18,247,518 effective HSP length: 111 effective length of query: 782 effective length of database: 14,044,392 effective search space: 10982714544 effective search space used: 10982714544 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.