Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 19913408

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens]
         (1621 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens]        3262   0.0  
gi|19913406 DNA topoisomerase II, alpha isozyme [Homo sapiens]       2112   0.0  
gi|55956788 nucleolin [Homo sapiens]                                   62   3e-09
gi|217330641 IWS1 homolog [Homo sapiens]                               62   5e-09
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    59   4e-08
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                    55   6e-07
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap...    54   9e-07
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap...    54   9e-07
gi|16445033 ACRC protein [Homo sapiens]                                54   9e-07
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    54   1e-06
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     54   1e-06
gi|59814411 hypothetical protein LOC253725 [Homo sapiens]              52   4e-06
gi|55741677 SET domain containing 1A [Homo sapiens]                    52   5e-06
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    51   8e-06
gi|133922600 splicing factor, arginine/serine-rich 16 [Homo sapi...    50   1e-05
gi|48255931 hepatoma-derived growth factor-related protein 2 iso...    50   2e-05
gi|14249158 hepatoma-derived growth factor-related protein 2 iso...    50   2e-05
gi|210032580 SET domain containing 1B [Homo sapiens]                   49   3e-05
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    49   3e-05
gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform...    49   4e-05
gi|38788333 remodeling and spacing factor 1 [Homo sapiens]             49   5e-05
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora...    48   7e-05
gi|54124343 hypothetical protein LOC387680 [Homo sapiens]              48   7e-05
gi|104526627 triadin [Homo sapiens]                                    48   7e-05
gi|154090959 hypothetical protein LOC55747 [Homo sapiens]              48   7e-05
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    48   9e-05
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1...    48   9e-05
gi|150170670 piccolo isoform 2 [Homo sapiens]                          48   9e-05
gi|150378539 piccolo isoform 1 [Homo sapiens]                          48   9e-05
gi|54112403 chromodomain helicase DNA binding protein 7 [Homo sa...    47   1e-04

>gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens]
          Length = 1621

 Score = 3262 bits (8458), Expect = 0.0
 Identities = 1621/1621 (100%), Positives = 1621/1621 (100%)

Query: 1    MAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHIL 60
            MAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHIL
Sbjct: 1    MAKSGGCGAGAGVGGGNGALTWVNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHIL 60

Query: 61   LRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTC 120
            LRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTC
Sbjct: 61   LRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTC 120

Query: 121  IKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNG 180
            IKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNG
Sbjct: 121  IKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNG 180

Query: 181  YGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLS 240
            YGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLS
Sbjct: 181  YGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLS 240

Query: 241  KFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGV 300
            KFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGV
Sbjct: 241  KFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGV 300

Query: 301  ALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKK 360
            ALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKK
Sbjct: 301  ALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKK 360

Query: 361  NKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASN 420
            NKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASN
Sbjct: 361  NKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASN 420

Query: 421  CGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDS 480
            CGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDS
Sbjct: 421  CGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDS 480

Query: 481  AKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDD 540
            AKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDD
Sbjct: 481  AKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDD 540

Query: 541  AESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNK 600
            AESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNK
Sbjct: 541  AESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNK 600

Query: 601  QELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 660
            QELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE
Sbjct: 601  QELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPE 660

Query: 661  DDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELI 720
            DDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELI
Sbjct: 661  DDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELI 720

Query: 721  LFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQAL 780
            LFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQAL
Sbjct: 721  LFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQAL 780

Query: 781  MMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDN 840
            MMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDN
Sbjct: 781  MMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDN 840

Query: 841  LLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLD 900
            LLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLD
Sbjct: 841  LLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLD 900

Query: 901  PHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPML 960
            PHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPML
Sbjct: 901  PHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPML 960

Query: 961  NGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD 1020
            NGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD
Sbjct: 961  NGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD 1020

Query: 1021 HMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKIT 1080
            HMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKIT
Sbjct: 1021 HMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKIT 1080

Query: 1081 IENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNY 1140
            IENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNY
Sbjct: 1081 IENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNY 1140

Query: 1141 ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQERE 1200
            ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQERE
Sbjct: 1141 ILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQERE 1200

Query: 1201 DVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDL 1260
            DVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDL
Sbjct: 1201 DVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDL 1260

Query: 1261 DTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPS 1320
            DTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPS
Sbjct: 1261 DTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPS 1320

Query: 1321 AKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDD 1380
            AKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDD
Sbjct: 1321 AKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDD 1380

Query: 1381 DDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFG 1440
            DDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFG
Sbjct: 1381 DDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFG 1440

Query: 1441 NLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVP 1500
            NLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVP
Sbjct: 1441 NLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVP 1500

Query: 1501 KPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTS 1560
            KPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTS
Sbjct: 1501 KPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTS 1560

Query: 1561 KTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMF 1620
            KTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMF
Sbjct: 1561 KTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMF 1620

Query: 1621 N 1621
            N
Sbjct: 1621 N 1621


>gi|19913406 DNA topoisomerase II, alpha isozyme [Homo sapiens]
          Length = 1531

 Score = 2112 bits (5471), Expect = 0.0
 Identities = 1091/1599 (68%), Positives = 1259/1599 (78%), Gaps = 96/1599 (6%)

Query: 25   NAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDV 84
            N  KK E       D+ K+LSVER+YQKKTQLEHILLRPDTYIGSVE +TQ MWVYDEDV
Sbjct: 16   NKIKKNE-------DAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDV 68

Query: 85   GMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVV 144
            G+N REVTFVPGLYKIFDEILVNAADNKQRD  M+CI+V+IDPE+N+ISIWNNGKGIPVV
Sbjct: 69   GINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVV 128

Query: 145  EHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKH 204
            EHKVEK+YVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA +EYK 
Sbjct: 129  EHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKK 188

Query: 205  SFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAG 264
             FKQTWM+NM +  E ++K F+GEDYTCITFQPDLSKFKM+ LDKDIVALM RRAYD+AG
Sbjct: 189  MFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAG 248

Query: 265  SCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGF 324
            S + VKV  NG KLPV GFRSYVD+Y+KDKLDETG +LKVIHE  N RW+VCLT+SEKGF
Sbjct: 249  STKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGF 308

Query: 325  QQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLI 384
            QQISFVNSIAT+KGGRHVDYV DQ+V KL++VVKKKNK GV+VK  QVKNH+W+F+N LI
Sbjct: 309  QQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALI 368

Query: 385  ENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCS 444
            ENPTFDSQTKENMTLQPKSFGS CQLSEKF KAA  CGIVESILNWVKFKAQ QLNKKCS
Sbjct: 369  ENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCS 428

Query: 445  SVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRG 504
            +VK+++IKGIPKLDDANDAGG++S ECTLILTEGDSAK+LAVSGLGV+GRD+YGVFPLRG
Sbjct: 429  AVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRG 488

Query: 505  KILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSH 564
            KILNVREASHKQIMENAEINNIIKIVGLQYKK+Y+D +SLKTLRYGKIMIMTDQDQDGSH
Sbjct: 489  KILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSH 548

Query: 565  IKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAW 624
            IKGLLINFIHHNWPSLL+H FLEEFITPIVK SKNKQE++FYS+PEF+EWK    N K W
Sbjct: 549  IKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKW 608

Query: 625  KIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNF 684
            K+KYYKGLGTST+KEAKEYFADM+RHRI F+Y+GPEDDAAI+LAFSKK+IDDRKEWLTNF
Sbjct: 609  KVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNF 668

Query: 685  MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRK 744
            MEDRRQR+L GLPE +LYG  T +LTYNDFINKELILFSNSDNERSIPS+VDG KPGQRK
Sbjct: 669  MEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRK 728

Query: 745  VLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIG 804
            VLFTCFKRNDKREVKVAQLAGSVAEMS+YHHGE +LMMTI+NLAQNFVGSNN+NLLQPIG
Sbjct: 729  VLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIG 788

Query: 805  QFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMV 864
            QFGTRLHGGKD+ASPRYIFTMLS+LARLLFP  DD+ LKFLYDDNQRVEPEWYIPIIPMV
Sbjct: 789  QFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMV 848

Query: 865  LINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYA 924
            LINGAEGIGTGW+CK+PN+D REIVNN+RR++DG +P PMLP+YKNFKGTI+EL  NQY 
Sbjct: 849  LINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYV 908

Query: 925  VSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKF 984
            +SGE+ +++  T+EI+ELPVRTWTQ YKEQVLEPMLNGT+KTP LI+DY+EYHTDTTVKF
Sbjct: 909  ISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKF 968

Query: 985  VVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLS 1044
            VVKMTEEKLA+AE  GLHKVFKLQT+LTCNSMVLFDH+GCLKKY+TV DIL++FF+LRL 
Sbjct: 969  VVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLK 1028

Query: 1045 YYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVK 1104
            YYGLRKEWL+GMLGAES KLNNQARFILEKI GKI IEN+ KK+LI++L+QRGY+SDPVK
Sbjct: 1029 YYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVK 1088

Query: 1105 AWKEAQEKAAEEDETQ---NQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQR 1161
            AWKEAQ+K  +E+E +   N+ +   SDS T SGP FNY+L+M LW LTKEK +EL + R
Sbjct: 1089 AWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLR 1148

Query: 1162 DAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVK 1221
            + K +E++ LKRKSPSDLWKEDLA F+EEL+ VE++E++D   G+ GK      GK K K
Sbjct: 1149 NEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKG-----GKAKGK 1203

Query: 1222 KLQLEETMPSPYGRRIIPEITA-MKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEG 1280
            K Q+ E +PSP G+R+IP IT  MKA+A KK  KK K +        E   +  G  +EG
Sbjct: 1204 KTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNE------NTEGSPQEDGVELEG 1257

Query: 1281 AGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESD 1340
              +               K++K+EPGT+ +K  T + KP  KK KKRNPWSD ES   SD
Sbjct: 1258 LKQRL------------EKKQKREPGTKTKKQTTLAFKP-IKKGKKRNPWSDSESDRSSD 1304

Query: 1341 LEETEPVVIPRDSLLRRAAAERPKYTFDFSEEED-DDADDDDDDNNDLEELKVKASPITN 1399
              E+   V PR++  RRAA  + K+T D   +ED  D D+  DD                
Sbjct: 1305 --ESNFDVPPRETEPRRAAT-KTKFTMDLDSDEDFSDFDEKTDD---------------- 1345

Query: 1400 DGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKF 1459
               ++FVPSD         SP K+K +P+ S  + K Q         S     E D  K 
Sbjct: 1346 ---EDFVPSDA--------SPPKTKTSPKLSNKELKPQK--------SVVSDLEADDVKG 1386

Query: 1460 DSNEEDSASVFSPSFGLKQTDKVPSKTV-----AAKKGKPSSDTVPKPKRAPKQKKVVEA 1514
                  S          + T+ VP K V     AAK    +S T  K + APK  K   A
Sbjct: 1387 SVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPA 1446

Query: 1515 VNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKT-TSKKPKKTSFD 1573
            +NS      G+ +K    K K R  +KRK S S+ + D N  +  SK  TSKK K  S D
Sbjct: 1447 LNS------GVSQKPDPAKTKNR--RKRKPSTSD-DSDSNFEKIVSKAVTSKKSKGESDD 1497

Query: 1574 QDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEE 1612
                   F  DF +      ++ RA+K +KY  ESDE++
Sbjct: 1498 -------FHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 65/270 (24%), Positives = 110/270 (40%), Gaps = 41/270 (15%)

Query: 1369 FSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPE 1428
            + E +    D+++++ +D E+   K+  +T+ G     P+     D   +   K K    
Sbjct: 1090 WKEAQQKVPDEEENEESDNEKETEKSDSVTDSG-----PTFNYLLDMPLWYLTKEKKDEL 1144

Query: 1429 KSLHDKKSQDFGNLFSFPSYSQKSEDDSAKF-------DSNEEDSASVFSPSFGLKQTDK 1481
              L ++K Q+   L    S S   ++D A F       ++ E+    V  P  G K   K
Sbjct: 1145 CRLRNEKEQELDTL-KRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGK 1203

Query: 1482 VP--SKTVAAKKGK---PSSDTVPKPKRAPKQKKVVEAVNSD-SDSEFGIPKKTTTPKGK 1535
                ++ + + +G+   P      K +   K KK ++  N++ S  E G+  +       
Sbjct: 1204 KTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELE------- 1256

Query: 1536 GRGAKKRKASGSENEGDYNPGRKTSKTTS------KKPKKTS--FDQDSDVDIFPSDFPT 1587
              G K+R     + E    PG KT K T+      KK KK +   D +SD     S+F  
Sbjct: 1257 --GLKQRLEKKQKRE----PGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDV 1310

Query: 1588 EPPSLPRTGRARKEVKYFAESDEEEDDVDF 1617
             PP      RA  + K+  + D +ED  DF
Sbjct: 1311 -PPRETEPRRAATKTKFTMDLDSDEDFSDF 1339


>gi|55956788 nucleolin [Homo sapiens]
          Length = 710

 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 72/284 (25%), Positives = 115/284 (40%), Gaps = 45/284 (15%)

Query: 1237 IIPEITAMKADAS--KKLLKK--KKGDLDTAAVK--VEFDEEFSGAPVEGAGEEALTPSV 1290
            +IP+    KA A+  KK++    KK  + T A K  V   ++ +  P +     A   + 
Sbjct: 47   VIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTT 106

Query: 1291 PINKGPKP-KREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVI 1349
            P  KG  P K     PG +    P    K + K  KK +   +++  SE D E+ E    
Sbjct: 107  PGKKGATPGKALVATPGKKGAAIPAKGAK-NGKNAKKEDSDEEEDDDSEEDEEDDEDEDE 165

Query: 1350 PRDSL---LRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFV 1406
              D +     +AAA  P    +  E+++DD DDDDD+ +D EE  ++ +P       + V
Sbjct: 166  DEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVV 225

Query: 1407 PSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDS 1466
            P              K+ A  E    D + +D  +        +  EDD  + D  EE+ 
Sbjct: 226  P-----------VKAKNVAEDEDEEEDDEDEDDDD-------DEDDEDDDDEDDEEEEE- 266

Query: 1467 ASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKK 1510
                       + ++ P K    K+ K     + K K AP+ KK
Sbjct: 267  -----------EEEEEPVKEAPGKRKK----EMAKQKAAPEAKK 295



 Score = 35.8 bits (81), Expect = 0.35
 Identities = 47/199 (23%), Positives = 68/199 (34%), Gaps = 18/199 (9%)

Query: 1421 GKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSAS-VFSPSFGLKQT 1479
            GK++  P+K     K  +           + SED+    D  ++ S   V  P    K+ 
Sbjct: 8    GKNQGDPKKMAPPPKEVE-----------EDSEDEEMSEDEEDDSSGEEVVIPQKKGKKA 56

Query: 1480 DKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGA 1539
                +K V     K  +   P  K A    K  +A  + +       K  TTP  KG   
Sbjct: 57   AATSAKKVVVSPTKKVAVATPAKKAAVTPGK--KAAATPAKKTVTPAKAVTTPGKKGATP 114

Query: 1540 KKRKASGSENEGDYNP--GRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGR 1597
             K   +    +G   P  G K  K   K+      D DS+ D    D   E         
Sbjct: 115  GKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEED--EEDDEDEDEDEDEIEP 172

Query: 1598 ARKEVKYFAESDEEEDDVD 1616
            A  +    A + E+EDD D
Sbjct: 173  AAMKAAAAAPASEDEDDED 191


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 119/524 (22%), Positives = 193/524 (36%), Gaps = 97/524 (18%)

Query: 1118 ETQNQHDDSSSDSGTPSGPDFNYILNMSLWSL--TKEKVEELIKQRDAKGREVNDLKRKS 1175
            E  ++++ S  + G P G       N    +L  +  + EEL +Q+D+   E  +     
Sbjct: 46   ERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDS-ESEERAEPP 104

Query: 1176 PSDLWKEDLAAFVEELDKVESQ-------EREDVLAGMSGKAIKGKVGKPKVKKLQLEET 1228
             SD   ED+     + +  E++       E E++L G +  +    VGK      ++EE 
Sbjct: 105  ASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEEL 164

Query: 1229 MPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTA-AVKVEFDEEFSGAPVEGAGEEALT 1287
              SP                          D +T  A+K +  +  S  P      ++  
Sbjct: 165  QKSP------------------------ASDSETEDALKPQISDSESEEPPRHQASDSEN 200

Query: 1288 PSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSE-----SDLE 1342
                  + PKP+    E      + P      S  +   R+  SD E++       SD E
Sbjct: 201  -----EEPPKPRMSDSES----EELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSE 251

Query: 1343 ETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGE 1402
              +P   PR         E PK     SE ED   +   D  N  EEL     P  +D E
Sbjct: 252  SEDP---PRHQASDSENEELPKPRISDSESEDPPRNQASDSEN--EEL---PKPRVSDSE 303

Query: 1403 DEFVPSDGLDKDEYTFSPGKSKATPEK-SLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDS 1461
             E  P  G   D  T    + K  PE     D++++         S+   S  D  KF S
Sbjct: 304  SE-GPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHS 362

Query: 1462 NEEDSASVFSPSFGLKQTDKV-PSKTVAAKKGKPSSDTVPKPKRAPKQKKVV-EAVNSDS 1519
            ++ +            + +K    + VA +K    SD+  + K + K+ +VV +A +SDS
Sbjct: 363  SDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDS 422

Query: 1520 DSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVD 1579
            D+        +   GK    +K  AS SE E                 K+ S  ++ + D
Sbjct: 423  DA-------VSDKSGK---REKTIASDSEEEAG---------------KELSDKKNEEKD 457

Query: 1580 IFPSDFPTEPPSLPRTGRARKEV--KYFAESDEEEDDVDFAMFN 1621
            +F SD          +G   + +    F ES +EE++ +F  FN
Sbjct: 458  LFGSD--------SESGNEEENLIADIFGESGDEEEE-EFTGFN 492



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 100/452 (22%), Positives = 164/452 (36%), Gaps = 60/452 (13%)

Query: 1094 VQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEK 1153
            + R  +SD     +     +  E+E  NQH   S    T   P  +      L     + 
Sbjct: 87   LHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDS 146

Query: 1154 VEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKG 1213
              E + +  A   E+ +L++   SD   ED         ++   E E+     +  +   
Sbjct: 147  ENEDVGKHPASDSEIEELQKSPASDSETEDALK-----PQISDSESEEPPRHQASDSENE 201

Query: 1214 KVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEF 1273
            +  KP++   + EE +P P       +++  +++   +       + +    ++  D E 
Sbjct: 202  EPPKPRMSDSESEE-LPKP-------QVSDSESEEPPRHQASDSENEELPKPRIS-DSES 252

Query: 1274 SGAPVEGAG----EEALTPSVPINKGPKPKREKKE-------PGTRV--------RKTPT 1314
               P   A     EE   P +  ++   P R +         P  RV        +K P 
Sbjct: 253  EDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPA 312

Query: 1315 SSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEED 1374
            S  +       K+ P SDD+S  E+  E+TE   +  DS    +  +R K+    SEEE+
Sbjct: 313  SDSETEDASRHKQKPESDDDSDRENKGEDTE---MQNDSFHSDSHMDRKKFHSSDSEEEE 369

Query: 1375 DDAD--DDDDDNNDLEELKV--KASPITNDGEDE--------FVPSDGLDKDEYTFSPGK 1422
                  D D+D  + EE KV  + + + +D EDE         V SD  D D    S   
Sbjct: 370  HKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKS 429

Query: 1423 SKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDS--ASVFSPS------- 1473
             K   EK++     ++ G   S     +K    S     NEE++  A +F  S       
Sbjct: 430  GKR--EKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEE 487

Query: 1474 -FGLKQTDKVPSKTVAAKKGKPSSDTVPKPKR 1504
              G  Q D    K     K    SD+    KR
Sbjct: 488  FTGFNQEDLEEEKGETQVKEAEDSDSDDNIKR 519


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 106/502 (21%), Positives = 181/502 (36%), Gaps = 77/502 (15%)

Query: 1108 EAQEKAAEEDETQNQHDDSSSDS----GTPSGPDFNYILNMSLWSLTKEKVEELIKQRDA 1163
            E +    +EDE      DSS++S    G   G + ++  ++   S +KE  +   K+ D 
Sbjct: 255  EDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKE-DP 313

Query: 1164 KGREVNDLKRKSPSD---LWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKV 1220
                  D   KS  +   + +++ +  +E+  K+  +E + V   ++ ++    VGK + 
Sbjct: 314  HNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQD 373

Query: 1221 KKLQLEETMPSPYGRRIIPEI---TAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAP 1277
            K ++++   PS   R I  E+      K D  +  +   KG++ T    V          
Sbjct: 374  KGIEIKG--PSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVN--------- 422

Query: 1278 VEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSA---------KKVKKRN 1328
            +EG G+                  K EPG +V  + T S   S          K ++  +
Sbjct: 423  IEGPGQ------------------KSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDD 464

Query: 1329 PWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLE 1388
            P S DES    D           +S  R  A+     + D     D    +DDD ++  +
Sbjct: 465  PNSSDESNGNDDANSESD----NNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSD 520

Query: 1389 ELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSY 1448
                 ++   N+G D        D D+     GKS ++   S     S D  +     S 
Sbjct: 521  TNNSDSNGNGNNGND--------DNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSS 572

Query: 1449 SQKSEDDSAKFD--------------SNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKP 1494
               S  DS   D              SN  DS+     S     +D   SK+ ++K    
Sbjct: 573  DSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESD 632

Query: 1495 SSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYN 1554
            SSD+  K   +        + NSDS S+      ++        +    +S S N  D +
Sbjct: 633  SSDSDSKSDSSDSNSS-DSSDNSDS-SDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSS 690

Query: 1555 PGRKTSKTTSKKPKKTSFDQDS 1576
                +S ++       S D DS
Sbjct: 691  DSSDSSNSSESSDSSDSSDSDS 712



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 37/212 (17%), Positives = 73/212 (34%), Gaps = 1/212 (0%)

Query: 1368 DFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATP 1427
            D S+  D D+ D +  ++        +    +D  D    SD  D  + + S   S ++ 
Sbjct: 562  DSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 621

Query: 1428 EKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTV 1487
             KS   K   D  +  S    S  +  DS+  +S+  DS++  + S     +D   S + 
Sbjct: 622  SKSDSSKSESDSSDSDSKSDSSDSNSSDSSD-NSDSSDSSNSSNSSDSSDSSDSSDSSSS 680

Query: 1488 AAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGS 1547
            +       S        + +     ++ +SDS          ++       +    +S S
Sbjct: 681  SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740

Query: 1548 ENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVD 1579
             +  D +    +S ++       S D     D
Sbjct: 741  SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 47/267 (17%), Positives = 91/267 (34%), Gaps = 3/267 (1%)

Query: 1315 SSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEED 1374
            SS   ++      +  SD    S+SD   +       DS     +++    + D S+  D
Sbjct: 794  SSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS-DSSDGSD 852

Query: 1375 DDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDK 1434
             D+ +  D +N  +      S  ++D  D    ++  +  + + S   S +    S +  
Sbjct: 853  SDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSS 912

Query: 1435 KSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKP 1494
             S D  N       S  S++ ++   SN  DS+     S     ++   S   +      
Sbjct: 913  DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSN 972

Query: 1495 SSDTVPKPKRAPKQKKVVEAVNSDS--DSEFGIPKKTTTPKGKGRGAKKRKASGSENEGD 1552
            SSD+      +        + +SDS   S       ++        +    +S S N  D
Sbjct: 973  SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032

Query: 1553 YNPGRKTSKTTSKKPKKTSFDQDSDVD 1579
             +    +S ++       S D  +  D
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSD 1059



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 53/266 (19%), Positives = 85/266 (31%), Gaps = 16/266 (6%)

Query: 1315 SSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEED 1374
            SS   S+      N     +S + SD  ++       DS    +       + D S+  D
Sbjct: 815  SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDS--DSSNRSDSSNSSDSSDSSD 872

Query: 1375 DDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDK 1434
                 D  D++D  E     S  ++D  D    SD    D    S     +    S    
Sbjct: 873  SSNSSDSSDSSDSNE-----SSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927

Query: 1435 KSQDFGNLFSFPSYSQKSEDDSAKFD-SNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGK 1493
             S D  N     S S  S D S   D SN  DS++    S     +D   S +  +    
Sbjct: 928  NSSDNSN----SSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSS 983

Query: 1494 PSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDY 1553
             SSD+      +       ++ NS   S+      ++        +    +S S +  D 
Sbjct: 984  DSSDSSDSSDSSDSS----DSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDS 1039

Query: 1554 NPGRKTSKTTSKKPKKTSFDQDSDVD 1579
            +    +S ++       S D     D
Sbjct: 1040 SDSSDSSDSSDSSDSSNSSDSSDSSD 1065



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 52/271 (19%), Positives = 93/271 (34%), Gaps = 29/271 (10%)

Query: 1314 TSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEE 1373
            + S   S+      +  S D S S +  E ++      DS    ++        + S+ +
Sbjct: 672  SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDS----SDSSDSDSSDSSDSSNSNSSDSD 727

Query: 1374 DDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHD 1433
              ++ D  D +N  +      S  ++D  D    S+  D  + + S   S ++     +D
Sbjct: 728  SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSND 787

Query: 1434 KKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGK 1493
              +    +  S  S S  S D S   DS++ DS++    S     +D   S +  +    
Sbjct: 788  SSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS--SNSSDSSDSS 845

Query: 1494 PSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDY 1553
             SSD                   SDSDS        +        +    +S S +  D 
Sbjct: 846  DSSD------------------GSDSDS-----SNRSDSSNSSDSSDSSDSSNSSDSSDS 882

Query: 1554 NPGRKTSKTTSKKPKKTSFDQDSDVDIFPSD 1584
            +   ++S ++       S D DS      SD
Sbjct: 883  SDSNESSNSSDSSDSSNSSDSDSSDSSNSSD 913



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 49/266 (18%), Positives = 87/266 (32%), Gaps = 15/266 (5%)

Query: 1315 SSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEED 1374
            SS    +      +  SD +S + SD   +       DS            + D S+  D
Sbjct: 835  SSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDS----------SNSSDSSDSSD 884

Query: 1375 DDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDK 1434
             +   +  D++D        S  +++  D    S+  D  E + S   S ++   +  D 
Sbjct: 885  SNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDS 944

Query: 1435 KSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVA-AKKGK 1493
                  +  S  S S  S + S   DSN  DS+   + S     +D   S   + +    
Sbjct: 945  SDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSS 1004

Query: 1494 PSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDY 1553
             SSD+      +       ++ NS   S       ++        +    +S S N  D 
Sbjct: 1005 DSSDS----SDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1060

Query: 1554 NPGRKTSKTTSKKPKKTSFDQDSDVD 1579
            +    +S ++       S D     D
Sbjct: 1061 SDSSDSSDSSDSSDSSDSSDSSESSD 1086



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 45/249 (18%), Positives = 87/249 (34%), Gaps = 11/249 (4%)

Query: 1331 SDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEEL 1390
            SD +S + SD  ++       DS     +++    +   +  +  D+ D  D ++     
Sbjct: 724  SDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 783

Query: 1391 KVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQ 1450
                S  ++D  D    SD  +  + + S   S +    S     S D  +     S S 
Sbjct: 784  DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSD----SSNSS 839

Query: 1451 KSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKK 1510
             S D S   D ++ DS++    S     +D   S          SSD+    + +     
Sbjct: 840  DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSN-----SSDSSDSSDSNESSNSSDS 894

Query: 1511 VVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKT 1570
               + +SDSDS       ++        +   ++S S +  + +    +S ++       
Sbjct: 895  SDSSNSSDSDSSDS--SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSN 952

Query: 1571 SFDQDSDVD 1579
            S D  +  D
Sbjct: 953  SSDSSNSSD 961



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 60/346 (17%), Positives = 105/346 (30%), Gaps = 25/346 (7%)

Query: 1246 ADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEP 1305
            +D+S       K + D++    + D   S +       ++   S   N            
Sbjct: 617  SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSD 676

Query: 1306 GTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKY 1365
             +    +  SS    +      +  SD    S+SD  ++       DS    ++      
Sbjct: 677  SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS------DSSNSNSSDSDSSN 730

Query: 1366 TFDFSEEEDD-DADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSK 1424
            + D S+  +  D+ D  D +N  +      S  ++D  D    SD  D    + S   S 
Sbjct: 731  SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSN 790

Query: 1425 ATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFD-----------SNEEDSASVFSPS 1473
            ++   S     S D  N       S  S+ DS+              SN  DS+     S
Sbjct: 791  SSD--SSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS 848

Query: 1474 FGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPK 1533
             G        S +  +     SSD+      +          N  S+S        ++  
Sbjct: 849  DGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDS-----NESSNSSDSSDSSNSSDS 903

Query: 1534 GKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVD 1579
                 +    +S S N  D +    +S  ++      S D     D
Sbjct: 904  DSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSD 949



 Score = 38.9 bits (89), Expect = 0.041
 Identities = 45/273 (16%), Positives = 90/273 (32%), Gaps = 3/273 (1%)

Query: 1314 TSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEE 1373
            +S+   S+      +     +S + SD  ++       DS     +++    +      +
Sbjct: 728  SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSND 787

Query: 1374 DDDADDDDDDNNDLEELKVKASPITNDGEDEFVP--SDGLDKDEYTFSPGKSKATPEKSL 1431
              ++ D  D +N  +      S  ++D  D      SD  +  + + S   S ++     
Sbjct: 788  SSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDS 847

Query: 1432 HDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKK 1491
             D    D  N     + S  S+   +   S+  DS+     S     +D   S    +  
Sbjct: 848  SDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSD 907

Query: 1492 GKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEG 1551
               SSD+      +   +    + NS+S S+      ++        +    +S S N  
Sbjct: 908  SSNSSDSSDSSNSSDSSESSNSSDNSNS-SDSSNSSDSSDSSDSSNSSDSSNSSDSSNSS 966

Query: 1552 DYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSD 1584
            D +    +  + S     +S   DS      SD
Sbjct: 967  DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSD 999



 Score = 38.9 bits (89), Expect = 0.041
 Identities = 60/305 (19%), Positives = 101/305 (33%), Gaps = 30/305 (9%)

Query: 1314 TSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEE 1373
            +S+   S+      N     +S   SD  ++       DS            + D S+  
Sbjct: 1015 SSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS----------SNSSDSSDSS 1064

Query: 1374 DDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHD 1433
            D     D  D++D  +     S  ++D  D    SD  D  + + S   S ++      D
Sbjct: 1065 DSSDSSDSSDSSDSSD-----SSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1119

Query: 1434 KKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGK 1493
              +    +  S  S S  S + S   DS+E   +S  S S          S +  +    
Sbjct: 1120 SSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDS----------SDSSDSSDSS 1169

Query: 1494 PSSDTVPKPKRAPKQKKVVEAVNSDS--DSEFGIPKKTTTPKGKGRGAKKRKASGSENEG 1551
             SSD+      +        + +SDS   S+      ++        +    +S S +  
Sbjct: 1170 DSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1229

Query: 1552 DYNPGRKTSKTTSKKPKKTSFD--QDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESD 1609
            D N    +S ++       S D    SD     SD   E  S  ++G         ++SD
Sbjct: 1230 DSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGS-DSDSD 1288

Query: 1610 EEEDD 1614
             E  D
Sbjct: 1289 SEGSD 1293



 Score = 38.5 bits (88), Expect = 0.053
 Identities = 49/251 (19%), Positives = 84/251 (33%), Gaps = 23/251 (9%)

Query: 1331 SDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDD-----DDDNN 1385
            SD      SD   +       DS     +++      D S+ E D +D D      D N 
Sbjct: 588  SDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSN- 646

Query: 1386 DLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSF 1445
                        ++D  D    SD  +    + S   S ++   S  D  +    +  S 
Sbjct: 647  ------------SSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD 694

Query: 1446 PSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRA 1505
             S S +S D S   DS+  DS    S S     +D   S +  +     SSD+      +
Sbjct: 695  SSNSSESSDSSDSSDSDSSDS----SDSSNSNSSDSDSSNSSDSSDSSNSSDS-SDSSDS 749

Query: 1506 PKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSK 1565
                   ++ +S + S+      ++        +    +S S +  D +    +S ++  
Sbjct: 750  SNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809

Query: 1566 KPKKTSFDQDS 1576
                 S D DS
Sbjct: 810  SDSSDSSDSDS 820



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 44/263 (16%), Positives = 82/263 (31%), Gaps = 11/263 (4%)

Query: 1315 SSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDF----S 1370
            SS    + +    +  SD  + S+SD  ++       DS     ++E    + +     S
Sbjct: 879  SSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDS 938

Query: 1371 EEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKS 1430
                D +D  D  N+         S  ++D  +    SD    D    S     +    S
Sbjct: 939  SNSSDSSDSSDSSNS-------SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDS 991

Query: 1431 LHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAK 1490
                 S D  N       S  S+  ++   SN  DS++    S     +D   S   +  
Sbjct: 992  SDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1051

Query: 1491 KGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENE 1550
                +S        +       ++ +S   SE      ++        +    +S S + 
Sbjct: 1052 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDS 1111

Query: 1551 GDYNPGRKTSKTTSKKPKKTSFD 1573
             D +    +S ++       S D
Sbjct: 1112 SDSSDSSDSSNSSDSSDSSDSSD 1134



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 35/213 (16%), Positives = 71/213 (33%), Gaps = 3/213 (1%)

Query: 1368 DFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATP 1427
            D S+  +     D  D++D  +    ++  ++D  D    SD  +  + + S   S ++ 
Sbjct: 975  DSSDSSNSSDSSDSSDSSDSSDSSDSSN--SSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032

Query: 1428 EKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNE-EDSASVFSPSFGLKQTDKVPSKT 1486
                 D       +  S  S S  S D S   DS++  DS+     S   + +D   S  
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSN 1092

Query: 1487 VAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASG 1546
             +       S        +       ++ NS   S+      ++        +   ++S 
Sbjct: 1093 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSD 1152

Query: 1547 SENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVD 1579
            S +  D +    +S ++       S +     D
Sbjct: 1153 SSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1185



 Score = 33.1 bits (74), Expect = 2.2
 Identities = 39/269 (14%), Positives = 83/269 (30%), Gaps = 5/269 (1%)

Query: 1316 SGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDD 1375
            S   S+ +    N     +S   S+  ++       +S     +++    +   S +  +
Sbjct: 851  SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSN 910

Query: 1376 DADDDDDDNNDLEELKVKASPITNDGE-----DEFVPSDGLDKDEYTFSPGKSKATPEKS 1430
             +D  D  N+        +S  +N  +     D    SD  +  + + S   S ++    
Sbjct: 911  SSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 970

Query: 1431 LHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAK 1490
             +   S D  N       S  S+   +   SN  DS+     S     +D   S   +  
Sbjct: 971  SNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS 1030

Query: 1491 KGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENE 1550
                 S        +       ++ NS   S+      ++        +   ++S S + 
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDS 1090

Query: 1551 GDYNPGRKTSKTTSKKPKKTSFDQDSDVD 1579
             + +    +S ++       S D     D
Sbjct: 1091 SNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1119


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 90/397 (22%), Positives = 151/397 (38%), Gaps = 57/397 (14%)

Query: 1225 LEETMPSPYGRRIIP---EITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGA 1281
            +++   S  GR+  P   + T  +    KK  KK        A K   +E   G  +E  
Sbjct: 536  IQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKK--------AEKAAAEEPRGGLKIESE 587

Query: 1282 GEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDL 1341
                L  S+P ++     +  ++P   ++K   SS +P+A+K KK    S    KS   +
Sbjct: 588  TPVDLASSMPSSRHKAATKGSRKPN--IKKESKSSPRPTAEK-KKYKSTSKSSQKSREII 644

Query: 1342 EETEPVVIPRDSLLRRAAAERPKYTFDF------SEEEDDDADDDDDDNNDLEELKVKAS 1395
            E         +S     +++ PKY          S  E++D+       + +EE K   S
Sbjct: 645  ETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEE-KELLS 703

Query: 1396 PITNDGEDEFVPSDGLDKDEYTFSPGK-----------SKATPEKSLHDKKSQDFGNLFS 1444
            P++ + +D +     +D +  T  PGK            K  PEK   + + Q    + +
Sbjct: 704  PLS-EPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQASEKVSN 762

Query: 1445 FPSYSQKSEDDS----AKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVP 1500
                  K+EDD+    +K    E+ +++   PS     +++  SK  AAK+     D +P
Sbjct: 763  KGKRKHKNEDDNRASESKKPKTEDKNSAGHKPS-----SNRESSKQSAAKE----KDLLP 813

Query: 1501 KPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKG---KGRGAKKRKASGSENEGDYNPGR 1557
             P      K        D  +E G  K+T +          + K  +  S+N    +  +
Sbjct: 814  SPAGPVPSK--------DPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQK 865

Query: 1558 KTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPR 1594
            KT   TS   K+      S     P   PT   S PR
Sbjct: 866  KTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPR 902


>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
          Length = 1758

 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 100/511 (19%), Positives = 188/511 (36%), Gaps = 48/511 (9%)

Query: 1074 KIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGT- 1132
            K   K   E++  K + +  V++ Y  D        +E+ A++   +N+  D+  +    
Sbjct: 1056 KAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKR 1115

Query: 1133 ---PSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVE 1189
                 G D ++    S   ++K +V E++K    +  E +  K     +  K  L+A  +
Sbjct: 1116 KTEEKGVDKDF--ESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAK 1173

Query: 1190 ELD-------KVESQEREDVLAGMSGK--AIKGKVGKPKVKKLQLEETMPSPYGRRIIPE 1240
            ++        K+ S E        S K  +   KV + KVK     +   +      + +
Sbjct: 1174 KIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVD 1233

Query: 1241 ITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKR 1300
             T+  +     + +K +   DT    ++  EE++      A +  +   VP +K  K   
Sbjct: 1234 YTSTSSTGGSPV-RKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDF 1292

Query: 1301 EKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAA 1360
            E +E   +  +  +S GKP++         S+     E + E +E +             
Sbjct: 1293 ESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKI------------- 1339

Query: 1361 ERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSP 1420
               K+T D S E          ++   E+ K      T D +   +  +  +K       
Sbjct: 1340 --QKFTKDVSHEIIQHEVKSSKNSASSEKGK------TKDRDYSVLEKENPEK------- 1384

Query: 1421 GKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTD 1480
             K+   PEK  +  +  + GN F   S S K    S K DS    S   F+P+   K+TD
Sbjct: 1385 RKNSTQPEKESNLDRLNEQGN-FKSLSQSSKEARTSDKHDSTRASSNKDFTPNRD-KKTD 1442

Query: 1481 KVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAK 1540
                +  ++K+    ++   +     + K       +    E  +PKK T    K   + 
Sbjct: 1443 YDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSP 1502

Query: 1541 KRKASGSENEGDYNPGRKTSKTTS--KKPKK 1569
             R     +++  Y+  R   +T S  K P K
Sbjct: 1503 SRDRKPHDHKATYDTKRPNEETKSVDKNPCK 1533



 Score = 38.5 bits (88), Expect = 0.053
 Identities = 47/235 (20%), Positives = 89/235 (37%), Gaps = 16/235 (6%)

Query: 1120 QNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDL 1179
            + +H   + ++   SG    YILN     + KE++   I +   K +       +  SDL
Sbjct: 1535 REKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDL 1594

Query: 1180 WKE-DLAAFVEELDKVESQE----REDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYG 1234
             +E D AAF  + ++ +S+     +E+  +G   K +K K+ +   + L     +     
Sbjct: 1595 TRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGIS 1654

Query: 1235 RRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINK 1294
            R         ++ +S  +   +      +  +       S    +   ++         K
Sbjct: 1655 RN--------QSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKK 1706

Query: 1295 GPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVI 1349
              K K+ KK  GT V    +   K   KK KK     D E + E D ++ + V +
Sbjct: 1707 HKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN---KDKEKEKEKDDQKVKSVTV 1758



 Score = 37.0 bits (84), Expect = 0.16
 Identities = 34/166 (20%), Positives = 63/166 (37%), Gaps = 13/166 (7%)

Query: 1412 DKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFS 1471
            + DE  F P  +++  E ++  K+ +  GN+      S+  +D   +      D+A+V  
Sbjct: 1597 ETDEAAFEPDYNESDSESNVSVKEEESSGNI------SKDLKDKIVEKAKESLDTAAVVQ 1650

Query: 1472 PSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTT 1531
                  Q+   PS +       PS    P   +         +  S    +    K+   
Sbjct: 1651 VGISRNQSHSSPSVS-------PSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKK 1703

Query: 1532 PKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSD 1577
             K   +  K +K +G+E E + +   K  K  SKK K    +++ D
Sbjct: 1704 HKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKD 1749



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 48/276 (17%), Positives = 102/276 (36%), Gaps = 36/276 (13%)

Query: 1299 KREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRA 1358
            +R++K   TR + +P+ +   ++ +  K     D   K   D +++        S  R  
Sbjct: 1453 RRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSN------SSPSRDR 1506

Query: 1359 AAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFV-----PSDGLDK 1413
                 K T+D     ++    D +   D E+  ++A        ++ +     P   ++K
Sbjct: 1507 KPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEK 1566

Query: 1414 DEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPS 1473
            ++ T    KS   P+  L               S+S +   D  +     E   + F P 
Sbjct: 1567 EQITGQIDKSTVKPKPQL---------------SHSSRLSSDLTR-----ETDEAAFEPD 1606

Query: 1474 FGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPK 1533
            +     ++  S++  + K + SS  + K  +    +K  E++++ +  + GI +  +   
Sbjct: 1607 Y-----NESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSS 1661

Query: 1534 GKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKK 1569
                 ++    SGS+     +         SKK KK
Sbjct: 1662 PSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1697


>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
          Length = 1792

 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 100/511 (19%), Positives = 188/511 (36%), Gaps = 48/511 (9%)

Query: 1074 KIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGT- 1132
            K   K   E++  K + +  V++ Y  D        +E+ A++   +N+  D+  +    
Sbjct: 1090 KAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKR 1149

Query: 1133 ---PSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVE 1189
                 G D ++    S   ++K +V E++K    +  E +  K     +  K  L+A  +
Sbjct: 1150 KTEEKGVDKDF--ESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAK 1207

Query: 1190 ELD-------KVESQEREDVLAGMSGK--AIKGKVGKPKVKKLQLEETMPSPYGRRIIPE 1240
            ++        K+ S E        S K  +   KV + KVK     +   +      + +
Sbjct: 1208 KIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVD 1267

Query: 1241 ITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKR 1300
             T+  +     + +K +   DT    ++  EE++      A +  +   VP +K  K   
Sbjct: 1268 YTSTSSTGGSPV-RKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDF 1326

Query: 1301 EKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAA 1360
            E +E   +  +  +S GKP++         S+     E + E +E +             
Sbjct: 1327 ESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKI------------- 1373

Query: 1361 ERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSP 1420
               K+T D S E          ++   E+ K      T D +   +  +  +K       
Sbjct: 1374 --QKFTKDVSHEIIQHEVKSSKNSASSEKGK------TKDRDYSVLEKENPEK------- 1418

Query: 1421 GKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTD 1480
             K+   PEK  +  +  + GN F   S S K    S K DS    S   F+P+   K+TD
Sbjct: 1419 RKNSTQPEKESNLDRLNEQGN-FKSLSQSSKEARTSDKHDSTRASSNKDFTPNRD-KKTD 1476

Query: 1481 KVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAK 1540
                +  ++K+    ++   +     + K       +    E  +PKK T    K   + 
Sbjct: 1477 YDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSP 1536

Query: 1541 KRKASGSENEGDYNPGRKTSKTTS--KKPKK 1569
             R     +++  Y+  R   +T S  K P K
Sbjct: 1537 SRDRKPHDHKATYDTKRPNEETKSVDKNPCK 1567



 Score = 38.5 bits (88), Expect = 0.053
 Identities = 47/235 (20%), Positives = 89/235 (37%), Gaps = 16/235 (6%)

Query: 1120 QNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDL 1179
            + +H   + ++   SG    YILN     + KE++   I +   K +       +  SDL
Sbjct: 1569 REKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDL 1628

Query: 1180 WKE-DLAAFVEELDKVESQE----REDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYG 1234
             +E D AAF  + ++ +S+     +E+  +G   K +K K+ +   + L     +     
Sbjct: 1629 TRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGIS 1688

Query: 1235 RRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINK 1294
            R         ++ +S  +   +      +  +       S    +   ++         K
Sbjct: 1689 RN--------QSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKK 1740

Query: 1295 GPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVI 1349
              K K+ KK  GT V    +   K   KK KK     D E + E D ++ + V +
Sbjct: 1741 HKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN---KDKEKEKEKDDQKVKSVTV 1792



 Score = 37.0 bits (84), Expect = 0.16
 Identities = 34/166 (20%), Positives = 63/166 (37%), Gaps = 13/166 (7%)

Query: 1412 DKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFS 1471
            + DE  F P  +++  E ++  K+ +  GN+      S+  +D   +      D+A+V  
Sbjct: 1631 ETDEAAFEPDYNESDSESNVSVKEEESSGNI------SKDLKDKIVEKAKESLDTAAVVQ 1684

Query: 1472 PSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTT 1531
                  Q+   PS +       PS    P   +         +  S    +    K+   
Sbjct: 1685 VGISRNQSHSSPSVS-------PSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKK 1737

Query: 1532 PKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSD 1577
             K   +  K +K +G+E E + +   K  K  SKK K    +++ D
Sbjct: 1738 HKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKD 1783



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 48/276 (17%), Positives = 102/276 (36%), Gaps = 36/276 (13%)

Query: 1299 KREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRA 1358
            +R++K   TR + +P+ +   ++ +  K     D   K   D +++        S  R  
Sbjct: 1487 RRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSN------SSPSRDR 1540

Query: 1359 AAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFV-----PSDGLDK 1413
                 K T+D     ++    D +   D E+  ++A        ++ +     P   ++K
Sbjct: 1541 KPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEK 1600

Query: 1414 DEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPS 1473
            ++ T    KS   P+  L               S+S +   D  +     E   + F P 
Sbjct: 1601 EQITGQIDKSTVKPKPQL---------------SHSSRLSSDLTR-----ETDEAAFEPD 1640

Query: 1474 FGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPK 1533
            +     ++  S++  + K + SS  + K  +    +K  E++++ +  + GI +  +   
Sbjct: 1641 Y-----NESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSS 1695

Query: 1534 GKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKK 1569
                 ++    SGS+     +         SKK KK
Sbjct: 1696 PSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKK 1731


>gi|16445033 ACRC protein [Homo sapiens]
          Length = 691

 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 59/253 (23%), Positives = 98/253 (38%), Gaps = 38/253 (15%)

Query: 1368 DFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEF-VPSDGLDKDEYTFSPGKSKAT 1426
            D S++  DD+ DD+ D++D+ + K   S + +D  D+  VP D  D  E           
Sbjct: 195  DSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEA 254

Query: 1427 PEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKT 1486
            P+ S  D ++ D             S+D  A  DS+++  AS  S        D   S  
Sbjct: 255  PDDSSDDSEAPD-----------DSSDDSEAPDDSSDDSEASDDSSDDSEASDDS--SDD 301

Query: 1487 VAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGK---------GR 1537
              A   K     VP+ K        V   NSD D E  +P +    +G+           
Sbjct: 302  SEAPDDKSDDSDVPEDK---SDDSDVPDDNSD-DLEVPVPAEDLCNEGQIASDEEELVEA 357

Query: 1538 GAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTE---PPSLPR 1594
             A   +   S++ G+ + G   SK  S        D +++ ++     PTE    P + +
Sbjct: 358  AAAVSQHDSSDDAGEQDLGENLSKPPS--------DPEANPEVSERKLPTEEEPAPVVEQ 409

Query: 1595 TGRARKEVKYFAE 1607
            +G+ + + K   E
Sbjct: 410  SGKRKSKTKTIVE 422



 Score = 38.1 bits (87), Expect = 0.070
 Identities = 54/249 (21%), Positives = 85/249 (34%), Gaps = 32/249 (12%)

Query: 1376 DADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKK 1435
            D D+DDD+ NDLE       P  N  + E  P D  D  E           P+ +  D +
Sbjct: 125  DDDNDDDNGNDLE------VPDDNSDDSE-APDDNSDDSEAPDDNSDDSEAPDDNSDDSE 177

Query: 1436 SQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSA---SVFSPSFGLKQTDKVPSKTVAAKKG 1492
            + D             + DDS   D N +DS+   S  S       +D    K+  +   
Sbjct: 178  APD------------DNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVP 225

Query: 1493 KPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGD 1552
              SSD    P  +    +  +  + DS++       +  P      ++    S  ++E  
Sbjct: 226  DDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAS 285

Query: 1553 YNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAE----- 1607
             +    +  +        + D  SD    P D  ++   +P       EV   AE     
Sbjct: 286  DDSSDDSEASDDSSDDSEAPDDKSDDSDVPED-KSDDSDVPDDNSDDLEVPVPAEDLCNE 344

Query: 1608 ----SDEEE 1612
                SDEEE
Sbjct: 345  GQIASDEEE 353


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
            sapiens]
          Length = 699

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 72/327 (22%), Positives = 112/327 (34%), Gaps = 34/327 (10%)

Query: 1308 RVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTF 1367
            +V +    +  P AKK KK+   SD E  SE + E   P         +R      K   
Sbjct: 62   KVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAA 121

Query: 1368 DFSEEEDDDADDDDDDNNDLEELKV-----------KASPITNDGEDEFVPSDGLDKDEY 1416
              SE    +   DDDD  D ++  V           KA P      D    S   D+   
Sbjct: 122  KASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPK 181

Query: 1417 TFSP--------GKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSAS 1468
               P         ++KA P+ +    K  +     S  S S  S  D    DS EE +A+
Sbjct: 182  NQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSD----DSEEEKAAA 237

Query: 1469 VFSPSFGLKQ-TDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPK 1527
                +   KQ   K P K       K SS          +QKK ++       S   +P 
Sbjct: 238  TPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSS---VPP 294

Query: 1528 KTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPT 1587
             +  P  K  G +  K +  + +    P   +  ++ +    +  ++        S   T
Sbjct: 295  PSAPPPKKSLGTQPPKKAVEKQQ----PVESSEDSSDESDSSSEEEKKPPTKAVVSKATT 350

Query: 1588 EPPSLPRTGRARKEVKYFAESDEEEDD 1614
            +PP   +   +  +    ++SD  EDD
Sbjct: 351  KPPPAKKAAESSSD---SSDSDSSEDD 374



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 114/552 (20%), Positives = 192/552 (34%), Gaps = 91/552 (16%)

Query: 1099 ESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELI 1158
            +  PV+   + Q KAA+    + +  DS SDS +   P  N           K K+  + 
Sbjct: 142  KKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQ----------KPKITPVT 191

Query: 1159 KQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKP 1218
             +   K        R +P     +  ++         S + E+  A  + K    K  K 
Sbjct: 192  VKAQTKAPPKP--ARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPK--KQ 247

Query: 1219 KVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKG---------------DLDTA 1263
             V K  ++             + ++ + +  KK +K K G                L T 
Sbjct: 248  VVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQ 307

Query: 1264 AVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKK 1323
              K   +++    PVE + + +       ++      E+K+P T+   +  ++  P AKK
Sbjct: 308  PPKKAVEKQ---QPVESSEDSS-------DESDSSSEEEKKPPTKAVVSKATTKPPPAKK 357

Query: 1324 VKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAA---------AERPKYTFDFSEE-- 1372
              + +  S D   SE D   ++P    ++S  + A          A  PK      ++  
Sbjct: 358  AAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLL 417

Query: 1373 -EDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSL 1431
                D+   +++++  EE K K    T                       K KAT + +L
Sbjct: 418  TRKADSSSSEEESSSSEEEKTKKMVATT----------------------KPKATAKAAL 455

Query: 1432 HDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKV-----PSKT 1486
                 Q        P  S+ S  DS    S EE+  +  S S   K+  KV     PSK 
Sbjct: 456  SLPAKQ-------APQGSRDSSSDSDSSSSEEEEEKT--SKSAVKKKPQKVAGGAAPSKP 506

Query: 1487 VAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASG 1546
             +AKKGK  S        + ++++  E +          PK   T     +  K  K S 
Sbjct: 507  ASAKKGKAESSNSSSSDDSSEEEE--EKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSE 564

Query: 1547 SENEGDYNPGRKTSKTTS-KKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKY- 1604
             E E         SK+ S KK K+    ++++           P + P+  +  K     
Sbjct: 565  EEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSP 624

Query: 1605 FAESDEEEDDVD 1616
            F    EEE +VD
Sbjct: 625  FRRVREEEIEVD 636



 Score = 33.1 bits (74), Expect = 2.2
 Identities = 61/297 (20%), Positives = 106/297 (35%), Gaps = 22/297 (7%)

Query: 1107 KEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEK--VEELIKQRDAK 1164
            K    K A E  + +   DSS D   PS P      + +  ++T +   V+     +   
Sbjct: 351  KPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPV 410

Query: 1165 GREVNDLKRKSPSDLWKEDLAAFVEELDK---VESQEREDVLAGMSGKAIKGKVGK---- 1217
            G     L RK+ S   +E+ ++  EE  K     ++ +    A +S  A +   G     
Sbjct: 411  GGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSS 470

Query: 1218 --PKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKK-------KGDLDTAAVKVE 1268
                    + EE   S    +  P+  A  A  SK    KK           D ++ + E
Sbjct: 471  SDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEE 530

Query: 1269 FDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRN 1328
               +  G+P   A +   T ++    G   K  ++E   + +     S   S KK K+  
Sbjct: 531  EKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNE 590

Query: 1329 PWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNN 1385
               + E+     ++   P   P+    R+   +R    F    EE+ + D    DN+
Sbjct: 591  AAKEAETPQAKKIKLQTPNTFPK----RKKGEKRASSPFRRVREEEIEVDSRVADNS 643


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 115/585 (19%), Positives = 207/585 (35%), Gaps = 80/585 (13%)

Query: 1059 AESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDE 1118
            +E+ K+N  A   +   Q +IT   R        L  R  E + +K+ K++ E+   E E
Sbjct: 301  SEAAKVNTDA---MRSAQEEITEYRRQ-------LQARTTELEALKSTKDSLERQRSELE 350

Query: 1119 TQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVN---DLKRKS 1175
             ++Q D +S                           +E I+Q DA+ R        + + 
Sbjct: 351  DRHQADIAS--------------------------YQEAIQQLDAELRNTKWEMAAQLRE 384

Query: 1176 PSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGR 1235
              DL    +A  +E     +  E E+   G          G PK+  +     + S    
Sbjct: 385  YQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKI 444

Query: 1236 RIIPE-----ITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSV 1290
            +++ +     +   +     ++ ++   + +  A + E  EE  G   E  G E  T S 
Sbjct: 445  KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504

Query: 1291 PINKGPKPKREKKEPGTRVRKTPTSSGKP---------------SAKKVKKRNPWSDDES 1335
            P  +   P++E K P     K+P  +  P                AK   K    S  E+
Sbjct: 505  PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564

Query: 1336 KSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKAS 1395
            KS    E   P  +      +  A E  K   +    E   +   ++  +  E      S
Sbjct: 565  KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAE----AKS 620

Query: 1396 PITNDGEDEFVPSDGLDKDEYTFSPGKSKA-TPEKSLH-DKKSQDFGNLFSFPSYSQKSE 1453
            P+  + +    P++ +   E   SP K +A +PEK+   +K+          P  ++   
Sbjct: 621  PVKEEAKS---PAE-VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKS 676

Query: 1454 DDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAP--KQKKV 1511
             + AK     E  +   + S  +K+  K P K  +  K +  S   P+  ++P  ++ K 
Sbjct: 677  PEKAKSPVKAEAKSPEKAKS-PVKEEAKSPEKAKSPVKEEAKS---PEKAKSPVKEEAKT 732

Query: 1512 VEAVNSDSDSEFGIPKKTTTP-KGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKT 1570
             E   S    E   P+K  +P K K    K  +A     E   +P  K  +      K+ 
Sbjct: 733  PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792

Query: 1571 SFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDV 1615
                +        D       +P+    ++EVK   + +E+  +V
Sbjct: 793  VKSPEKAKSPLKEDAKAPEKEIPK----KEEVKSPVKEEEKPQEV 833



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 102/480 (21%), Positives = 178/480 (37%), Gaps = 73/480 (15%)

Query: 1102 PVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQR 1161
            P KA    +E+A    E ++   + +        P+          S TKE+ +   K +
Sbjct: 601  PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPE-------KAKSPTKEEAKSPEKAK 653

Query: 1162 DAKGREVNDL-KRKSP-------SDLWKEDLAAFVEELDKVESQEREDVLAGMSGKA-IK 1212
              +  E     K KSP        +  K  + A  +  +K +S  +E+  +    K+ +K
Sbjct: 654  SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK 713

Query: 1213 GKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEE 1272
             +   P+  K  ++E   +P   +   +  A   + +K   K K  D+ +   K    EE
Sbjct: 714  EEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773

Query: 1273 FSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSD 1332
             + +P +   E+A +P   + +  K   + K P     K P    K   KK + ++P  +
Sbjct: 774  -ARSPADKFPEKAKSP---VKEEVKSPEKAKSPLKEDAKAPE---KEIPKKEEVKSPVKE 826

Query: 1333 DESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKV 1392
            +E   E  ++E      P        A   PK T +  + + ++A   +     +EE K 
Sbjct: 827  EEKPQEVKVKE------PPKKAEEEKAPATPK-TEEKKDSKKEEAPKKEAPKPKVEEKKE 879

Query: 1393 KASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKS 1452
             A     + + E    +  DK        K   TPEK                P+  +  
Sbjct: 880  PAVEKPKESKVEAKKEEAEDK--------KKVPTPEKEA--------------PAKVEVK 917

Query: 1453 ED----DSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQ 1508
            ED    +  +    E D A    PS   K  +K   K  A +K     +   KP+  PK 
Sbjct: 918  EDAKPKEKTEVAKKEPDDAKAKEPS---KPAEK---KEAAPEKKDTKEEKAKKPEEKPK- 970

Query: 1509 KKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPK 1568
                EA   + D    + K+ + PK     A+K + S S ++ D  P  K ++  + K K
Sbjct: 971  ---TEAKAKEDDKT--LSKEPSKPK-----AEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 114/585 (19%), Positives = 200/585 (34%), Gaps = 80/585 (13%)

Query: 1063 KLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQ 1122
            K+ + +  I  K + KI +  +S+K+ + ++ ++  E+   +   E +EK A+E+E + +
Sbjct: 428  KIPSVSTHIKVKSEEKIKVVEKSEKETV-IVEEQTEETQVTEEVTEEEEKEAKEEEGKEE 486

Query: 1123 HDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKE 1182
                  ++                     E  EE  K   A+     + + KSP    KE
Sbjct: 487  EGGEEEEA---------------------EGGEEETKSPPAEEAASPEKEAKSPV---KE 522

Query: 1183 DLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEIT 1242
            +  +  E     +S E+E+  +         +V  P+  K   +E   SP   +  PE  
Sbjct: 523  EAKSPAE----AKSPEKEEAKS-------PAEVKSPEKAKSPAKEEAKSPPEAKS-PEKE 570

Query: 1243 AMKADASKKLLKKKKGDLDTAAVKVEFDE--EFSGAPVEGAGEEALTPSVPINKGPKPKR 1300
              K+ A  K  +K K      A      +  E + +PV+   +       P+ +  K   
Sbjct: 571  EAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA 630

Query: 1301 EKKEPGTRVRKTPTSSGKPSAKKVK---KRNPWSDDESKSESDLEETEPVVIPRDSLLRR 1357
            E K P     K+PT     S +K K   K    S +++KS    E   P      S ++ 
Sbjct: 631  EVKSP--EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE--KAKSPVKA 686

Query: 1358 AAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKD--- 1414
             A    K      EE             + +  +   SP+  + +        + ++   
Sbjct: 687  EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS 746

Query: 1415 -EYTFSPGKSKA---------TPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEE 1464
             E   SP K+K          TP K      +  F      P   +    + AK    E+
Sbjct: 747  PEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKED 806

Query: 1465 DSA---------SVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKR--------APK 1507
              A          V SP    ++  +V  K    K  +  +   PK +         APK
Sbjct: 807  AKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPK 866

Query: 1508 QKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKP 1567
            ++     V    +     PK++     K     K+K    E E    P +   K  +K  
Sbjct: 867  KEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEA---PAKVEVKEDAKPK 923

Query: 1568 KKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEE 1612
            +KT   +    D    + P++P         +K+ K       EE
Sbjct: 924  EKTEVAKKEPDDAKAKE-PSKPAEKKEAAPEKKDTKEEKAKKPEE 967


>gi|59814411 hypothetical protein LOC253725 [Homo sapiens]
          Length = 1318

 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 75/294 (25%), Positives = 114/294 (38%), Gaps = 55/294 (18%)

Query: 1373 EDDDADDDDD-----DNNDLEELKVKASP-ITNDGEDEFVPSDGLDKDEYTFSP-GKSKA 1425
            +DDD DDDDD      +   +  KV+++  I  D E +      +   E T S   ++KA
Sbjct: 452  DDDDGDDDDDFFSAPHSKPSKTRKVQSTADIFGDEEGDLFKEKAVASPEATVSQTDENKA 511

Query: 1426 TPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSP--SFGLKQTDKVP 1483
              EK +    S++       PS   K++       S+EEDS  +FS   +  LK    +P
Sbjct: 512  RAEKKVTLSYSKNLK-----PSSETKTQKG---LFSDEEDSEDLFSSQSASNLKGASLLP 563

Query: 1484 SKT-------------------VAAKKGKPS--SDTVPKPKRAPKQKKVVEAVNSDSDSE 1522
             K                     AAKK   S  +    K K +   KK   A+   SD E
Sbjct: 564  GKLPTSVSLFDDEDEEDNLFGGTAAKKQTLSLQAQREEKAKASELSKKKASALLFSSDEE 623

Query: 1523 FGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTS--------------KTTSKKPK 1568
            + IP   T      R   + + SG+    +    +KTS              K + KK +
Sbjct: 624  WNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDKEDDLFAIAKDSQKKTQ 683

Query: 1569 KTSFDQDSDVDIFPSDFPTEPPSLPRTGRARK---EVKYFAESDEEEDDVDFAM 1619
            + S   + DVD   S F + P S+P   + ++   E      SDEEE +    +
Sbjct: 684  RVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAQLGV 737



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 73/326 (22%), Positives = 119/326 (36%), Gaps = 53/326 (16%)

Query: 1333 DESKSESDLEETEPVVIPRDSLLRRAAAE-----RPKYTFDFSEEEDDDADDDDDDNNDL 1387
            D  K E D+E+ E    P+ S     A E     +        EE       +      L
Sbjct: 264  DSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAMGRVDEEPTTLPSGEAKPRKTL 323

Query: 1388 EELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPS 1447
            +E K + +P  ++ ++ F P    D+D   F  G    +  K L D + ++  +LF    
Sbjct: 324  KEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGLFSGGKGLFDDEDEE-SDLF---- 378

Query: 1448 YSQKSEDDSAKFDSNEEDSAS-------VFSPSFGLKQTDKVPSKTVAAKK--GKPSSDT 1498
             ++ S+D  A     EE S+S         + S  L  TD   + +V + K   KP   T
Sbjct: 379  -TEASQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFGAASVPSLKEPQKPEQPT 437

Query: 1499 VPKPKRAPKQKKVVEAVNSDSDSEF-----GIPKKTTTPKG--------KGRGAKKRKAS 1545
              K    P    + +  + D D +F       P KT   +         +G   K++  +
Sbjct: 438  PRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTRKVQSTADIFGDEEGDLFKEKAVA 497

Query: 1546 GSE---NEGDYNPGRKTSKTT------------SKKPKKTSFDQDSDVDIFPSDFPTE-- 1588
              E   ++ D N  R   K T            +K  K    D++   D+F S   +   
Sbjct: 498  SPEATVSQTDENKARAEKKVTLSYSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASNLK 557

Query: 1589 -PPSLPRTGRARKEVKYFAESDEEED 1613
                LP  G+    V  F + DEE++
Sbjct: 558  GASLLP--GKLPTSVSLFDDEDEEDN 581


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 73/330 (22%), Positives = 112/330 (33%), Gaps = 64/330 (19%)

Query: 1279 EGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSE 1338
            E + E+   PS P  +      ++KE G          G+P  K  K+      DE + +
Sbjct: 905  EASEEKRPRPSTPAEEDEDDPEQEKEAG--------EPGRPGTKPPKR------DEERGK 950

Query: 1339 SDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPIT 1398
            +  +        R S    +  E         ++E+DD +D++D++ +      K     
Sbjct: 951  TQGKH-------RKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEV 1003

Query: 1399 NDGEDEFVPSDGLDK-DEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSA 1457
            +DGEDE   SD   K   Y  S G++ +T +       S    +  S  S S  S  +S+
Sbjct: 1004 SDGEDE--ESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESS 1061

Query: 1458 KFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNS 1517
              D  EE+                   +  A     P    VP P  AP +  V E V  
Sbjct: 1062 SEDEEEEE-------------------RPAALPSASPPPREVPVPTPAPVEVPVPERV-- 1100

Query: 1518 DSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSD 1577
                  G P    TP  +   +  R A  +E      P R                    
Sbjct: 1101 -----AGSP---VTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPR------ 1146

Query: 1578 VDIFPSDFPTEP-PSLPRTGRARKEVKYFA 1606
                P + P+ P P LP   + RK V + A
Sbjct: 1147 ----PDERPSSPIPLLPPPKKRRKTVSFSA 1172


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
            sapiens]
          Length = 916

 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 104/508 (20%), Positives = 193/508 (37%), Gaps = 52/508 (10%)

Query: 1084 RSKKDLI----QMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFN 1139
            RS K+ I    + L  +  E + V+  KE+ E+   + E ++ HD SS            
Sbjct: 311  RSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQ---LE 367

Query: 1140 YILNMSLWSLTKE--KVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQ 1197
              L  + W + +   + ++L+  + A   E+   ++    +  +   + F   +      
Sbjct: 368  NELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGE--ETRFSTFAGSITGPLYT 425

Query: 1198 EREDVLAGMSGKAIKGKVGKPKVKKLQ------LEETMPSPYGRRIIPEITAMKADASKK 1251
             R  +   +S K  K KV  PK+K         +EET        +   +TA+  + +  
Sbjct: 426  HRPPIT--ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVS 483

Query: 1252 LLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEP------ 1305
            + ++KK   +    + E +EE   A  + +  +A  P V   +G K + E +E       
Sbjct: 484  MKEEKKEAAEEKEEEPEAEEEEVAA--KKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 541

Query: 1306 GTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKY 1365
            G +  +      +      K+     + E+++E++ EE E     +        A + + 
Sbjct: 542  GAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 601

Query: 1366 TFDFSEEEDDDADDDDDDNNDLEELK--VKASPITNDGEDEFV--PSDGLDKDEYTFSPG 1421
              D   E+ + A      +   E+ K  V  SP+   G+      P +   K     SP 
Sbjct: 602  VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 661

Query: 1422 KSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDK 1481
            + K     S    + +    +   P    KS+ +  K +  EE+           K+  +
Sbjct: 662  EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEE----------KEVKE 711

Query: 1482 VPSKTVAAKKGKPSSDTVPKPKRAP---KQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRG 1538
             P +    KK +   D VP+ K+A    K++ V E V      +  + K+T   +GK   
Sbjct: 712  APKEEKVEKKEEKPKD-VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE-EGKPLQ 769

Query: 1539 AKKRK-----ASGSENEGDYNPGRKTSK 1561
             +K K       GSE EG  + G K S+
Sbjct: 770  QEKEKEKAGGEGGSEEEGS-DKGAKGSR 796



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 62/263 (23%), Positives = 106/263 (40%), Gaps = 28/263 (10%)

Query: 1082 ENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYI 1141
            E  +KK  ++       E +  K  +E QE+  EEDE       + SD     G +    
Sbjct: 505  EVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE------GAKSDQAEEGGSEKEGS 558

Query: 1142 LNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQERED 1201
                     + + E   +  +A+ +E   ++ KS     KE+L A      KVE  E+  
Sbjct: 559  SEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADA----KVEKPEKAK 614

Query: 1202 VLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKK-KGDL 1260
                 S    K   GK  V K  +EE   SP  +  + E    K+   K  +++K K  +
Sbjct: 615  SPVPKSPVEEK---GKSPVPKSPVEEKGKSPVPKSPVEE--KGKSPVPKSPVEEKGKSPV 669

Query: 1261 DTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPS 1320
              + V+ +       +PVE A  +A      + KG + + E+KE    V++ P       
Sbjct: 670  SKSPVEEKAKSPVPKSPVEEAKSKA-----EVGKGEQKEEEEKE----VKEAPKEEKVEK 720

Query: 1321 AKKVKKRNPWSDDESKSESDLEE 1343
             ++  K  P   ++ K+ES ++E
Sbjct: 721  KEEKPKDVP---EKKKAESPVKE 740



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 60/305 (19%), Positives = 107/305 (35%), Gaps = 26/305 (8%)

Query: 1318 KPSAKKVKKRNPWSDD---ESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEED 1374
            K  A K+K ++ + ++   E+K E +  E E  +      L  +  E  K   +  EEE 
Sbjct: 440  KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 499

Query: 1375 DDADDDDDDNNDLEELKVKASPI------TNDGEDEFVPSDGLDKDEYTFSPGKSKATPE 1428
            +  +         EE+  K SP+        + E E    +G +++E      KS    E
Sbjct: 500  EAEE---------EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550

Query: 1429 KSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVA 1488
                +K+               ++E +  + ++ EE      S     K+     +K   
Sbjct: 551  GG-SEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEK 609

Query: 1489 AKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSE 1548
             +K K     VPK     K K  V     +   +  +PK     KGK    K       +
Sbjct: 610  PEKAK---SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 666

Query: 1549 NEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAES 1608
            +    +P  + +K  S  PK    +  S  ++   +   E         A KE K   + 
Sbjct: 667  SPVSKSPVEEKAK--SPVPKSPVEEAKSKAEVGKGEQKEEEEK--EVKEAPKEEKVEKKE 722

Query: 1609 DEEED 1613
            ++ +D
Sbjct: 723  EKPKD 727


>gi|133922600 splicing factor, arginine/serine-rich 16 [Homo sapiens]
          Length = 674

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 62/267 (23%), Positives = 103/267 (38%), Gaps = 32/267 (11%)

Query: 1086 KKDLIQMLVQRGY--ESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILN 1143
            KK L +     GY  E   V   ++A EK  EE+    +  +S  D   P     +  + 
Sbjct: 153  KKKLAEKKASIGYTYEDSTVAEVEKAAEKPEEEESAAEEESNSDEDEVIP-----DIDVE 207

Query: 1144 MSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVL 1203
            + +  L +E+V +L KQ    G    D  R    D  KE+     E +   ++ E E  +
Sbjct: 208  VDVDELNQEQVADLNKQATTYGMADGDFVRMLRKD--KEE----AEAIKHAKALEEEKAM 261

Query: 1204 AGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMK---ADASKKLLKKKKGDL 1260
               SG+  + +  + + K+L+  +  P  Y RR  P     K   +++S +   + +   
Sbjct: 262  --YSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTYDPYKRSPSESSSESRSRSRSPT 319

Query: 1261 DTAAVKVEFDEEFSGAPVEGAGEEALT----------PSVPINKGPKPKREKKEPGTRVR 1310
                 K+ F   F G+  E A   A            P+ P   GP P R      +  R
Sbjct: 320  PGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPPAPPQPGGPAPGRN----ASARR 375

Query: 1311 KTPTSSGKPSAKKVKKRNPWSDDESKS 1337
            ++ +SS   SA +       S   S+S
Sbjct: 376  RSSSSSSSSSASRTSSSRSSSRSSSRS 402



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 50/242 (20%), Positives = 87/242 (35%), Gaps = 49/242 (20%)

Query: 1359 AAERPKYTFDFSEEEDDDADD----DDDDNNDLEELKVKASPITNDGEDEFVPSDG---- 1410
            AAE+P+     +EEE +  +D    D D   D++EL  +     N     +  +DG    
Sbjct: 178  AAEKPEEEESAAEEESNSDEDEVIPDIDVEVDVDELNQEQVADLNKQATTYGMADGDFVR 237

Query: 1411 ---LDKDEYTFSPGKSKATPEKSLHD-----KKSQDF------GNLFSFPSYSQKSEDDS 1456
                DK+E            EK+++      ++ ++F      G   S PSY+++     
Sbjct: 238  MLRKDKEEAEAIKHAKALEEEKAMYSGRRSRRQRREFREKRLRGRKISPPSYARRDSPTY 297

Query: 1457 AKFDSNEEDSAS-----------------VFSPSFGLKQTDKVPSKTVAAKK----GKPS 1495
              +  +  +S+S                  F  SFG    +   +   AA      GKP 
Sbjct: 298  DPYKRSPSESSSESRSRSRSPTPGREEKITFITSFGGSDEEAAAAAAAAAASGVTTGKPP 357

Query: 1496 SDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNP 1555
            +   P+P      +       S S S      +T++ +   R + + +  G    G Y  
Sbjct: 358  AP--PQPGGPAPGRNASARRRSSSSSSSSSASRTSSSRSSSRSSSRSRRGG----GYYRS 411

Query: 1556 GR 1557
            GR
Sbjct: 412  GR 413


>gi|48255931 hepatoma-derived growth factor-related protein 2 isoform
            1 [Homo sapiens]
          Length = 671

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 77/324 (23%), Positives = 120/324 (37%), Gaps = 67/324 (20%)

Query: 1317 GKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDD 1376
            GKP+ +K      W    +   S      P V   DS       E P    + +  +  D
Sbjct: 69   GKPNKRKGFNEGLWEIQNNPHAS--YSAPPPVSSSDS-------EAP----EANPADGSD 115

Query: 1377 ADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKS 1436
            AD+DD+D   +    V A+  ++  E +       D D+ + + G  + TP   +   K 
Sbjct: 116  ADEDDEDRGVMAVTAVTATAASDRMESD------SDSDKSSDNSGLKRKTPALKMSVSKR 169

Query: 1437 QDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSS 1496
                      +    S+ D A    +EE+++   S S      D  P K  A        
Sbjct: 170  ----------ARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAA-------- 211

Query: 1497 DTVPKPKRAP----KQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGD 1552
              V  P+R P    K+KK   A  SDSDS+         P    R A    +S S ++ D
Sbjct: 212  --VRAPRRGPLGGRKKKKAPSA--SDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSD 267

Query: 1553 YN-----PGRKTS-----KTTSKKPK------KTSFDQDSDVDIFPSDFPTEPPSLPRTG 1596
             +      GRK +     K   +KPK       +S D DSD     S++     +  R  
Sbjct: 268  VSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRREL 327

Query: 1597 RARK------EVKYFAESDEEEDD 1614
             AR+      E++   E ++EE +
Sbjct: 328  EARRRREQEEELRRLREQEKEEKE 351



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 75/344 (21%), Positives = 124/344 (36%), Gaps = 99/344 (28%)

Query: 1243 AMKADASKKLLKKKKGDLDTAAVKVEFDEEF-SGAPVEGAGEEALTPSVPINKGPKPKRE 1301
            A+K   SK+  +K   DLD A+V    +E   S +  E   ++  TP            E
Sbjct: 161  ALKMSVSKRA-RKASSDLDQASVSPSEEENSESSSESEKTSDQDFTP------------E 207

Query: 1302 KKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAE 1361
            KK      R+ P        +K KK    SD +SK++SD  + EPV + R +        
Sbjct: 208  KKAAVRAPRRGPLGG-----RKKKKAPSASDSDSKADSDGAKPEPVAMARSA-------- 254

Query: 1362 RPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPG 1421
                    S      +  D D       + VK  P      ++ +P            P 
Sbjct: 255  --------SSSSSSSSSSDSD-------VSVKKPPRGRKPAEKPLP-----------KPR 288

Query: 1422 KSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDK 1481
              K  PE+                P  S  S+ DS + D   E            K+ D+
Sbjct: 289  GRKPKPER----------------PPSSSSSDSDSDEVDRISE-----------WKRRDE 321

Query: 1482 VPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSD-SDSEFGI-------------PK 1527
               + + A++ +   + + + +   K++K      +D  ++E G              P 
Sbjct: 322  ARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPV 381

Query: 1528 KTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTS 1571
            K    KG+GRG     +S SE E +     + +K ++KKP+ +S
Sbjct: 382  KKRGRKGRGRGPP--SSSDSEPEAEL---EREAKKSAKKPQSSS 420


>gi|14249158 hepatoma-derived growth factor-related protein 2 isoform
            2 [Homo sapiens]
          Length = 670

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 77/324 (23%), Positives = 120/324 (37%), Gaps = 67/324 (20%)

Query: 1317 GKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDD 1376
            GKP+ +K      W    +   S      P V   DS       E P    + +  +  D
Sbjct: 69   GKPNKRKGFNEGLWEIQNNPHAS--YSAPPPVSSSDS-------EAP----EANPADGSD 115

Query: 1377 ADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKS 1436
            AD+DD+D   +    V A+  ++  E +       D D+ + + G  + TP   +   K 
Sbjct: 116  ADEDDEDRGVMAVTAVTATAASDRMESD------SDSDKSSDNSGLKRKTPALKMSVSKR 169

Query: 1437 QDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSS 1496
                      +    S+ D A    +EE+++   S S      D  P K  A        
Sbjct: 170  ----------ARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEKKAA-------- 211

Query: 1497 DTVPKPKRAP----KQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGD 1552
              V  P+R P    K+KK   A  SDSDS+         P    R A    +S S ++ D
Sbjct: 212  --VRAPRRGPLGGRKKKKAPSA--SDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSD 267

Query: 1553 YN-----PGRKTS-----KTTSKKPK------KTSFDQDSDVDIFPSDFPTEPPSLPRTG 1596
             +      GRK +     K   +KPK       +S D DSD     S++     +  R  
Sbjct: 268  VSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRREL 327

Query: 1597 RARK------EVKYFAESDEEEDD 1614
             AR+      E++   E ++EE +
Sbjct: 328  EARRRREQEEELRRLREQEKEEKE 351



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 75/344 (21%), Positives = 124/344 (36%), Gaps = 99/344 (28%)

Query: 1243 AMKADASKKLLKKKKGDLDTAAVKVEFDEEF-SGAPVEGAGEEALTPSVPINKGPKPKRE 1301
            A+K   SK+  +K   DLD A+V    +E   S +  E   ++  TP            E
Sbjct: 161  ALKMSVSKRA-RKASSDLDQASVSPSEEENSESSSESEKTSDQDFTP------------E 207

Query: 1302 KKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAE 1361
            KK      R+ P        +K KK    SD +SK++SD  + EPV + R +        
Sbjct: 208  KKAAVRAPRRGPLGG-----RKKKKAPSASDSDSKADSDGAKPEPVAMARSA-------- 254

Query: 1362 RPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPG 1421
                    S      +  D D       + VK  P      ++ +P            P 
Sbjct: 255  --------SSSSSSSSSSDSD-------VSVKKPPRGRKPAEKPLP-----------KPR 288

Query: 1422 KSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDK 1481
              K  PE+                P  S  S+ DS + D   E            K+ D+
Sbjct: 289  GRKPKPER----------------PPSSSSSDSDSDEVDRISE-----------WKRRDE 321

Query: 1482 VPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSD-SDSEFGI-------------PK 1527
               + + A++ +   + + + +   K++K      +D  ++E G              P 
Sbjct: 322  ARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPV 381

Query: 1528 KTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTS 1571
            K    KG+GRG     +S SE E +     + +K ++KKP+ +S
Sbjct: 382  KKRGRKGRGRGPP--SSSDSEPEAEL---EREAKKSAKKPQSSS 420


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 50/190 (26%), Positives = 84/190 (44%), Gaps = 26/190 (13%)

Query: 1283 EEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVK-KRNPWSDDESKSESDL 1341
            ++ L PS  +++  + +  ++E    +  TP    K   K V  +R P    E  S  + 
Sbjct: 978  QKRLRPSTSVDE--EDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEE 1035

Query: 1342 EETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDG 1401
            +E E +   ++S      AE          EE+++ DDDDDD++D +E +       ND 
Sbjct: 1036 DEKESLSEEQESTEEEEEAE----------EEEEEEDDDDDDSDDRDESE-------NDD 1078

Query: 1402 EDEFV-----PSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDF-GNLFSFPSYSQKSEDD 1455
            ED  +       +G   +E T S   SKA    S    +S +F  +  S PS S+  E+ 
Sbjct: 1079 EDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEV 1138

Query: 1456 SAKFDSNEED 1465
             A+ +  EE+
Sbjct: 1139 VAREEEEEEE 1148



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 58/258 (22%), Positives = 97/258 (37%), Gaps = 46/258 (17%)

Query: 1108 EAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMS------------LWSLTKEKVE 1155
            E +E+A EE+E ++  DD S D       D +  L+ +              S+   K E
Sbjct: 1049 EEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAE 1108

Query: 1156 ELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKV 1215
                   ++  E       SPS    E+     EE    E +E E+++A           
Sbjct: 1109 ATSSSESSESSEFESSSESSPSSSEDEEEVVAREE---EEEEEEEEMVA----------- 1154

Query: 1216 GKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSG 1275
                      EE+M S       PE    + D  +  L      +D+  ++ E D E   
Sbjct: 1155 ----------EESMASAG-----PE--DFEQDGEEAALAPGAPAVDSLGMEEEVDIETEA 1197

Query: 1276 APVEGAGEEALTPSVPIN-KGPKPKRE-KKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDD 1333
               E        P +P+  + P   RE  +EPG         S +P AK+V+ R P S +
Sbjct: 1198 VAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPE 1257

Query: 1334 ES-KSESDLEETEPVVIP 1350
             + + + ++E   P+++P
Sbjct: 1258 RAPEHDLEVEPEPPMMLP 1275


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
            sapiens]
          Length = 1220

 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 73/324 (22%), Positives = 126/324 (38%), Gaps = 49/324 (15%)

Query: 1325 KKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDN 1384
            KK+   S+D +K + DL+     +    +    A  + P+ +    ++E    D D+DD 
Sbjct: 3    KKQKNKSEDSTKDDIDLDALAAEIEGAGA----AKEQEPQKSKGKKKKEKKKQDFDEDDI 58

Query: 1385 -NDLEELKVKASPI-----------TNDGEDEFVPSD----GLDKDEYTFSPGKSKATPE 1428
              +LEEL ++A  I           T + E+EF   D    G    + +F    S+   +
Sbjct: 59   LKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELED 118

Query: 1429 KSLHDKK-----------SQDFGNLFSFPSYSQ-KSEDDSAKFDSNEEDSASVFSPSFGL 1476
            K    KK           S D  +    P  ++ K++  + K+D +EED  +    S  +
Sbjct: 119  KDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDN----SKKI 174

Query: 1477 KQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKK-----VVEAVNSDSDSEFGIPKKTTT 1531
            K+  ++ S   + + G  S + +   K   K +K      +E+ N D D+ F I  KT  
Sbjct: 175  KERSRINS---SGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKI--KTVA 229

Query: 1532 PKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKK--PKKTSFDQDSDVDIFPSDFPTEP 1589
             K   +  ++RK    E         K    T KK   K+    +  + +   S    + 
Sbjct: 230  QKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDT 289

Query: 1590 PSLPRTGRARKEVKYFAESDEEED 1613
              +P     + E    AE D E D
Sbjct: 290  GVIP-ASEEKAETPTAAEDDNEGD 312



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 96/486 (19%), Positives = 180/486 (37%), Gaps = 55/486 (11%)

Query: 1063 KLNNQARFILEKIQGKITIENRSKK----DLIQMLVQRGYESDPVKAWKEAQEKAAEED- 1117
            K   +A+   +K  G    E+ SKK      I    + G ESD     ++ Q+K  +   
Sbjct: 149  KAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKP 208

Query: 1118 ----ETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKR 1173
                E+ N+ DD+S    T +                 EK E   K+RD +  ++  LK 
Sbjct: 209  GPNIESGNEDDDASFKIKTVA-------------QKKAEKKERERKKRDEEKAKLRKLKE 255

Query: 1174 KSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSG--KAIKGKVGKPKVKKLQLEETMPS 1231
            K   +  K+D +   E   K E +  +  +   +G   A + K   P   +   E     
Sbjct: 256  KEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNE----- 310

Query: 1232 PYGRRIIPEITAMKADASKKLLKKKKGD-------LDTAAVKVEFDEEFSGAPVEGAGEE 1284
              G +   +    K +  +K  +KKKG        +  A  K++ +EE      E   + 
Sbjct: 311  --GDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKR 368

Query: 1285 ALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEET 1344
                     +  + ++EK+E   +  K      K   K + K    +   +++   L + 
Sbjct: 369  LEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQA 428

Query: 1345 EPVVIP-RDSLLRRAAAERPKYTFDFSEE-EDDDADDDDDDNNDLEEL------KVKASP 1396
            + V +P +DSL ++      K      ++ E  +  +  +    +E +      K +  P
Sbjct: 429  QGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPP 488

Query: 1397 ITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLH--------DKKSQDFGNLFSFPSY 1448
                 E+E     GLD  E   S  +++      +H        +++ ++        S 
Sbjct: 489  PVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESE 548

Query: 1449 SQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRA-PK 1507
             ++ E+  ++    +E+   V       K  DK PSK +++     S D   K +RA  K
Sbjct: 549  EEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDK 608

Query: 1508 QKKVVE 1513
             K+ +E
Sbjct: 609  AKRRIE 614


>gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform a
            [Homo sapiens]
          Length = 845

 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 70/290 (24%), Positives = 104/290 (35%), Gaps = 49/290 (16%)

Query: 1298 PKREKKEP---GTRVRKTPTSSGKPSAKKVKK-RNPWSDDESKSESDLEETEPVVIPRDS 1353
            PK++  EP   G     +P+       KK KK +  + ++ +  +    E E V+  ++ 
Sbjct: 5    PKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQ 64

Query: 1354 LLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDK 1413
              ++   ++ K           D DDD ++   +E LK K S  T+D EDE         
Sbjct: 65   QQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK-KLSVPTSDEEDE--------- 114

Query: 1414 DEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPS 1473
                         P       K    GN+F+     Q  E+        EE+      P+
Sbjct: 115  ------------VPAPKPRGGKKTKGGNVFAALIQDQSEEE--------EEEEKHPPKPA 154

Query: 1474 FGLKQ--TDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTT 1531
               K      V  +   A KGK   +   K K  P Q K     N + D E  I K+   
Sbjct: 155  KPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKP-QNKFAALDNEEEDKEEEIIKEKEP 213

Query: 1532 PK-GKGRGAKKRKASGSENEGDY-----------NPGRKTSKTTSKKPKK 1569
            PK GK +  K  + S  E EG+            +P    SK   KK KK
Sbjct: 214  PKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKK 263



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 51/239 (21%), Positives = 92/239 (38%), Gaps = 40/239 (16%)

Query: 1149 LTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSG 1208
            + K   EEL  +    G E   LK K      ++      ++ D  + + ++DV      
Sbjct: 37   IKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQK--KKRDTRKGRRKKDVDDDGEE 94

Query: 1209 KAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVE 1268
            K +  ++ K  V     E+ +P+P            K    KK    K G++  A ++ +
Sbjct: 95   KELMERLKKLSVPTSDEEDEVPAP------------KPRGGKKT---KGGNVFAALIQDQ 139

Query: 1269 FDEEFSGAPVEGAGEEALTPSVPI----NKGPKPKREKKEPGTRVRKTPTSSGKPSAKKV 1324
             +EE          EE   P  P     N+  K   E+++P  + +K      K  AK  
Sbjct: 140  SEEE---------EEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQ 190

Query: 1325 KKRNPW-SDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDD 1382
             K     +++E K E  ++E EP          +   E+ K     SEEE +  +++++
Sbjct: 191  NKFAALDNEEEDKEEEIIKEKEPP---------KQGKEKAKKAEQGSEEEGEGEEEEEE 240


>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
          Length = 1441

 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 65/286 (22%), Positives = 109/286 (38%), Gaps = 42/286 (14%)

Query: 1356 RRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSD------ 1409
            R AAA R K         D D+D + D+    +E K     I++  +DEFV SD      
Sbjct: 1079 RAAAARRKKRR----RLNDLDSDSNLDEEESEDEFK-----ISDGSQDEFVVSDENPDES 1129

Query: 1410 -----GLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEE 1464
                   D  +  F   + +  P + +   +          P      +D+  + + N  
Sbjct: 1130 EEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRL----RRKTPKKKYSDDDEEEESEENSR 1185

Query: 1465 DSASVFSPSFG-------LKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNS 1517
            DS S FS  F         +++ +   + +  K+   S  +    +R  + ++V +   S
Sbjct: 1186 DSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLS 1245

Query: 1518 DSDSEFGIPKKTT----TPKGKGRGAKKRKASGSE-NEGDYNPGRKTSKTTSKKPKKTSF 1572
             S+SE     K +      K   R  +KR  S  E +E D     +  K + K+  +   
Sbjct: 1246 SSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIET 1305

Query: 1573 DQDSDVDIFPSDF-----PTEPPSLPRTGRARKEVKYFAESDEEED 1613
            D++   D    D       ++P  LP    + K+  Y  ESDEEED
Sbjct: 1306 DEEESCDNAHGDANQPARDSQPRVLPSEQESTKK-PYRIESDEEED 1350


>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
            homolog, Drosophila); translocated to, 1 [Homo sapiens]
          Length = 559

 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 71/330 (21%), Positives = 125/330 (37%), Gaps = 48/330 (14%)

Query: 1286 LTPSVPINKGPKPKREKKEPGTR-VRKTPTSSGKP-SAKKVKKRNPWSDDESKSESDLEE 1343
            + P++P++    PK+ K   G++   K  + + KP    K  +  P  D ESKS S   E
Sbjct: 160  MLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELE 219

Query: 1344 TEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKA-SPITNDGE 1402
             E     +D+  +      PK      E+         +    L+E K+++ SP      
Sbjct: 220  REQAKSSKDTSRKLGEGRLPK-----EEKAPPPKAAFKEPKMALKETKLESTSPKGGPPP 274

Query: 1403 DEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSN 1462
                P     K   T    K  A  +K    K S+                  SA   S 
Sbjct: 275  PPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSR------------------SAPGTSP 316

Query: 1463 EEDSASVFSPSFGLKQTDKVPSKTVAAKKG-KPSSDTVPKPKRAPKQKKVVEAVNSDSDS 1521
               S+S FS        DK P+K  ++ +G K  +++ P   R  K+   VE  NS+ ++
Sbjct: 317  RTSSSSSFS--------DKKPAKDKSSTRGEKVKAESEP---REAKKALEVEESNSEDEA 365

Query: 1522 EFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIF 1581
             F      ++P      +    +S S ++ D+ P +  S+   +   +    ++SD D  
Sbjct: 366  SFKSESAQSSP------SNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDED-- 417

Query: 1582 PSDFPTEPPSLPRTGRARKEVKYFAESDEE 1611
              D  +   +  +T   R     F++S+ +
Sbjct: 418  --DSSSGEEAAGKTNPGRDSRLSFSDSESD 445


>gi|54124343 hypothetical protein LOC387680 [Homo sapiens]
          Length = 1341

 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 72/292 (24%), Positives = 107/292 (36%), Gaps = 50/292 (17%)

Query: 1374 DDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDG-LDKDEYTFSPGK--SKATPEKS 1430
            DDD  DDDDD       K   +       D F   +G L K++   SP    S+    K+
Sbjct: 452  DDDDGDDDDDFFSAPHSKPSKTGKVQSTADIFGDEEGDLFKEKAVASPEATVSQTDENKA 511

Query: 1431 LHDKKSQDFGNLFSFPSYSQKSEDDSAK-FDSNEEDSASVFSPSFG--LKQTDKVPSKT- 1486
              +KK      L S  +    SE  + K   S+EEDS  +FS      LK    +P K  
Sbjct: 512  RAEKKV----TLSSSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASKLKGASLLPGKLP 567

Query: 1487 ------------------VAAKKG----KPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFG 1524
                               AAKK     +   +   K     K+K      +SD + ++ 
Sbjct: 568  TLVSLFDDEDEEDNLFGGTAAKKQTLCLQAQREEKAKASELSKKKASALLFSSDEEDQWN 627

Query: 1525 IPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTS--------------KTTSKKPKKT 1570
            IP   T      R   + + SG+    +    +KTS              K + KK ++ 
Sbjct: 628  IPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDDLFAIAKDSQKKTQRV 687

Query: 1571 SFDQDSDVDIFPSDFPTEPPSLPRTGRARK---EVKYFAESDEEEDDVDFAM 1619
            S   + DVD   S F + P S+P   + ++   E      SDEEE +    +
Sbjct: 688  SLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAQLGV 739



 Score = 40.0 bits (92), Expect = 0.018
 Identities = 72/327 (22%), Positives = 117/327 (35%), Gaps = 55/327 (16%)

Query: 1333 DESKSESDLEETEPVVIPRDSLLRRAAAE-----RPKYTFDFSEEEDDDADDDDDDNNDL 1387
            D  K E D+E+ E    P+ S     A E     +        EE       +      L
Sbjct: 264  DSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAVGRVDEEPTTLPSGEAKPRKTL 323

Query: 1388 EELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPS 1447
            +E K + +P  ++ ++ F P    D+D   F  G    +  K L D + ++  +LF    
Sbjct: 324  KEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGLFSGGKGLFDDEDEE-SDLF---- 378

Query: 1448 YSQKSEDDSAKFDSNEEDSAS-------VFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVP 1500
             ++  +D  A     EE S+S         + S  L  TD   + +V + K +P     P
Sbjct: 379  -TEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFGAASVPSMK-EPQKPEQP 436

Query: 1501 KPKRAPKQKKVV----EAVNSDSDSEFGIPKKTTTPKGKGRGAK-----------KRKAS 1545
             P+++P          +    D D  F  P    +  GK +              K KA 
Sbjct: 437  TPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTGKVQSTADIFGDEEGDLFKEKAV 496

Query: 1546 GSE----NEGDYNPGRKTSKTT------------SKKPKKTSFDQDSDVDIFPSDFPTE- 1588
             S     ++ D N  R   K T            +K  K    D++   D+F S   ++ 
Sbjct: 497  ASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASKL 556

Query: 1589 --PPSLPRTGRARKEVKYFAESDEEED 1613
                 LP  G+    V  F + DEE++
Sbjct: 557  KGASLLP--GKLPTLVSLFDDEDEEDN 581


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 101/482 (20%), Positives = 176/482 (36%), Gaps = 44/482 (9%)

Query: 1151 KEKVEELIK-QRDAKGREVNDLKRKSPSD-LWKEDLAAFVEELDKVESQEREDVLAGMSG 1208
            KEKV E  K ++ A  +E  + K K  +  L KE   A   E  K E + +++V     G
Sbjct: 171  KEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAE--KSEEKTKKEV---KGG 225

Query: 1209 KAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVE 1268
            K  K K    KVK++Q   + P              K D  K  + K +     A  +  
Sbjct: 226  KQEKVKQTAAKVKEVQKTPSKPKE------------KEDKEKAAVSKHEQKDQYAFCRYM 273

Query: 1269 FDEEFSGAPVEGAGEEALTPSVPINKGPKP----------KREKKEPGTRVRKTPTSSGK 1318
             D  F    ++     A+ P +P  +  +P          + EKK+   +V        K
Sbjct: 274  IDI-FVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEK 332

Query: 1319 PSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDAD 1378
               KK  ++    D E K      ET+   +    +  +AAA++ +   D S++    A+
Sbjct: 333  EDIKKKSEKETAIDVEKKEPGKASETKQGTV---KIAAQAAAKKDEKKED-SKKTKKPAE 388

Query: 1379 DDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATP-EKSLHDKKSQ 1437
             +       E+ +    P  +  ++  VPSD   K +   +  +  A   +K++  KK +
Sbjct: 389  VEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEE 448

Query: 1438 DFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSD 1497
                        +KS   S+     E            LK  +K P      K  K   +
Sbjct: 449  KTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLK--EKEPETKKDEKMSKAGKE 506

Query: 1498 TVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGR 1557
              PKP +   +K+         +++  I +K    K      +K  + G   E      +
Sbjct: 507  VKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVK 566

Query: 1558 KTS--KTTSKKPKKTSFDQDSDVDIFPSDFPTEPP----SLPRTGRARKEVKYFAESDEE 1611
              +  KT   KP K +  ++ +     +D P   P     +  +G+ + E+    ES E+
Sbjct: 567  AVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISE-KESKEK 625

Query: 1612 ED 1613
             D
Sbjct: 626  AD 627



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 88/420 (20%), Positives = 149/420 (35%), Gaps = 67/420 (15%)

Query: 1148 SLTKEKVEELIKQRDAKGREVNDLKRKSPSDL--WKEDLAAFVEELDKVESQEREDVLAG 1205
            S TK+K +E IK++  K   + D+++K P      K+       +    + +++ED    
Sbjct: 325  SETKKKEKEDIKKKSEKETAI-DVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKT 383

Query: 1206 MSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAV 1265
                 ++   GK + KK +  E   SP     +P    +KA   +               
Sbjct: 384  KKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAK------------- 430

Query: 1266 KVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVK 1325
                         E  G  ++  +VP   G K ++  K     +RK    SGK S+  +K
Sbjct: 431  -------------EEIGAVSIKKAVP---GKKEEKTTKTVEQEIRKE--KSGKTSSI-LK 471

Query: 1326 KRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAE---RPKYTFDFSEEEDDDADDDDD 1382
             + P    E K  + L+E EP    +D  + +A  E   +P       EE+ +       
Sbjct: 472  DKEPIKGKEEKVPASLKEKEPET-KKDEKMSKAGKEVKPKPPQLQGKKEEKPE------- 523

Query: 1383 DNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNL 1442
                  ++K +A P  +  E   +    + K E T S GK +   EK L   K+      
Sbjct: 524  -----PQIKKEAKPAIS--EKVQIHKQDIVKPEKTVSHGKPE---EKVLKQVKA------ 567

Query: 1443 FSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKP 1502
             +    ++      A+    E  S     P    K T +V   T + KK    S+   K 
Sbjct: 568  VTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEV---TESGKKKTEISEKESKE 624

Query: 1503 KRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEG--DYNPGRKTS 1560
            K   K  +  +        +     K   P    +  +   AS    EG  D +P ++ S
Sbjct: 625  KADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKS 684



 Score = 37.0 bits (84), Expect = 0.16
 Identities = 58/294 (19%), Positives = 110/294 (37%), Gaps = 38/294 (12%)

Query: 1354 LLRRAAAERPKYTFDF---------SEEEDDDADDDDDDNNDLEELKVKASPITNDGEDE 1404
            L+R A  E   + + F         SE+E+DD  D+D D  +++E  ++   I  D  ++
Sbjct: 91   LVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEK 150

Query: 1405 FVPSD--------------GLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQ 1450
                +              G +K      P K KAT ++ +  K+  +   L      ++
Sbjct: 151  QEKPERKIQTKVTHKEKEKGKEKVREKEKPEK-KATHKEKIEKKEKPETKTLAKEQKKAK 209

Query: 1451 KSE--DDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQ 1508
             +E  ++  K +        V   +  +K+  K PSK     K K   +     K   K 
Sbjct: 210  TAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKP----KEKEDKEKAAVSKHEQKD 265

Query: 1509 K----KVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGS--ENEGDYNPGRKTSKT 1562
            +    + +  +    D + G       P    + ++   AS +  E EG+     K   +
Sbjct: 266  QYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTS 325

Query: 1563 TSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRT--GRARKEVKYFAESDEEEDD 1614
             +KK +K    + S+ +        EP     T  G  +   +  A+ DE+++D
Sbjct: 326  ETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKED 379


>gi|154090959 hypothetical protein LOC55747 [Homo sapiens]
          Length = 1253

 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 72/292 (24%), Positives = 107/292 (36%), Gaps = 50/292 (17%)

Query: 1374 DDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDG-LDKDEYTFSPGK--SKATPEKS 1430
            DDD  DDDDD       K   +       D F   +G L K++   SP    S+    K+
Sbjct: 364  DDDDGDDDDDFFSAPHSKPSKTGKVQSTADIFGDEEGDLFKEKAVASPEATVSQTDENKA 423

Query: 1431 LHDKKSQDFGNLFSFPSYSQKSEDDSAK-FDSNEEDSASVFSPSFG--LKQTDKVPSKT- 1486
              +KK      L S  +    SE  + K   S+EEDS  +FS      LK    +P K  
Sbjct: 424  RAEKKV----TLSSSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASKLKGASLLPGKLP 479

Query: 1487 ------------------VAAKKG----KPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFG 1524
                               AAKK     +   +   K     K+K      +SD + ++ 
Sbjct: 480  TSVSLFDDEDEEDNLFGGTAAKKQTLCLQAQREEKAKASELSKKKASALLFSSDEEDQWN 539

Query: 1525 IPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTS--------------KTTSKKPKKT 1570
            IP   T      R   + + SG+    +    +KTS              K + KK ++ 
Sbjct: 540  IPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEEDEEDDLFAIAKDSQKKTQRV 599

Query: 1571 SFDQDSDVDIFPSDFPTEPPSLPRTGRARK---EVKYFAESDEEEDDVDFAM 1619
            S   + DVD   S F + P S+P   + ++   E      SDEEE +    +
Sbjct: 600  SLLFEDDVDSRGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAQLGV 651



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 72/327 (22%), Positives = 117/327 (35%), Gaps = 55/327 (16%)

Query: 1333 DESKSESDLEETEPVVIPRDSLLRRAAAE-----RPKYTFDFSEEEDDDADDDDDDNNDL 1387
            D  K E D+E+ E    P+ S     A E     +        EE       +      L
Sbjct: 176  DSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGDAVGRVDEEPTTLPSGEAKPRKTL 235

Query: 1388 EELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPS 1447
            +E K + +P  ++ ++ F P    D+D   F  G    +  K L D + ++  +LF    
Sbjct: 236  KEKKERRTPSDDEEDNLFTPPKLTDEDFSPFGSGGGLFSGGKGLFDDEDEE-SDLF---- 290

Query: 1448 YSQKSEDDSAKFDSNEEDSAS-------VFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVP 1500
             ++  +D  A     EE S+S         + S  L  TD   + +V + K +P     P
Sbjct: 291  -TEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFGAASVPSMK-EPQKPEQP 348

Query: 1501 KPKRAPKQKKVV----EAVNSDSDSEFGIPKKTTTPKGKGRGAK-----------KRKAS 1545
             P+++P          +    D D  F  P    +  GK +              K KA 
Sbjct: 349  TPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTGKVQSTADIFGDEEGDLFKEKAV 408

Query: 1546 GSE----NEGDYNPGRKTSKTT------------SKKPKKTSFDQDSDVDIFPSDFPTE- 1588
             S     ++ D N  R   K T            +K  K    D++   D+F S   ++ 
Sbjct: 409  ASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSDEEDSEDLFSSQSASKL 468

Query: 1589 --PPSLPRTGRARKEVKYFAESDEEED 1613
                 LP  G+    V  F + DEE++
Sbjct: 469  KGASLLP--GKLPTSVSLFDDEDEEDN 493


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
            sapiens]
          Length = 540

 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 39/380 (10%)

Query: 1206 MSGKAIKGKVGKPKVKKLQ------LEETMPSPYGRRIIPEITAMKADASKKLLKKKKGD 1259
            +S K  K KV  PK+K         +EET        +   +TA+  + +  + ++KK  
Sbjct: 56   ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEA 115

Query: 1260 LDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEP------GTRVRKTP 1313
             +    + E +EE   A  + +  +A  P V   +G K + E +E       G +  +  
Sbjct: 116  AEEKEEEPEAEEEEVAA--KKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAE 173

Query: 1314 TSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEE 1373
                +      K+     + E+++E++ EE E     +        A + +   D   E+
Sbjct: 174  EGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEK 233

Query: 1374 DDDADDDDDDNNDLEELK--VKASPITNDGEDEFV--PSDGLDKDEYTFSPGKSKATPEK 1429
             + A      +   E+ K  V  SP+   G+      P +   K     SP + K     
Sbjct: 234  PEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV 293

Query: 1430 SLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAA 1489
            S    + +    +   P    KS+ +  K +  EE+           K+  + P +    
Sbjct: 294  SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEE----------KEVKEAPKEEKVE 343

Query: 1490 KKGKPSSDTVPKPKRAP---KQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRK--- 1543
            KK +   D VP+ K+A    K++ V E V      +  + K+T   +GK    +K K   
Sbjct: 344  KKEEKPKD-VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE-EGKPLQQEKEKEKA 401

Query: 1544 --ASGSENEGDYNPGRKTSK 1561
                GSE EG  + G K S+
Sbjct: 402  GGEGGSEEEGS-DKGAKGSR 420



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 62/263 (23%), Positives = 106/263 (40%), Gaps = 28/263 (10%)

Query: 1082 ENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYI 1141
            E  +KK  ++       E +  K  +E QE+  EEDE       + SD     G +    
Sbjct: 129  EVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE------GAKSDQAEEGGSEKEGS 182

Query: 1142 LNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQERED 1201
                     + + E   +  +A+ +E   ++ KS     KE+L A      KVE  E+  
Sbjct: 183  SEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADA----KVEKPEKAK 238

Query: 1202 VLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKK-KGDL 1260
                 S    K   GK  V K  +EE   SP  +  + E    K+   K  +++K K  +
Sbjct: 239  SPVPKSPVEEK---GKSPVPKSPVEEKGKSPVPKSPVEE--KGKSPVPKSPVEEKGKSPV 293

Query: 1261 DTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPS 1320
              + V+ +       +PVE A  +A      + KG + + E+KE    V++ P       
Sbjct: 294  SKSPVEEKAKSPVPKSPVEEAKSKA-----EVGKGEQKEEEEKE----VKEAPKEEKVEK 344

Query: 1321 AKKVKKRNPWSDDESKSESDLEE 1343
             ++  K  P   ++ K+ES ++E
Sbjct: 345  KEEKPKDVP---EKKKAESPVKE 364



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 60/305 (19%), Positives = 107/305 (35%), Gaps = 26/305 (8%)

Query: 1318 KPSAKKVKKRNPWSDD---ESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEED 1374
            K  A K+K ++ + ++   E+K E +  E E  +      L  +  E  K   +  EEE 
Sbjct: 64   KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEP 123

Query: 1375 DDADDDDDDNNDLEELKVKASPI------TNDGEDEFVPSDGLDKDEYTFSPGKSKATPE 1428
            +  +         EE+  K SP+        + E E    +G +++E      KS    E
Sbjct: 124  EAEE---------EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174

Query: 1429 KSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVA 1488
                +K+               ++E +  + ++ EE      S     K+     +K   
Sbjct: 175  GG-SEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEK 233

Query: 1489 AKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSE 1548
             +K K     VPK     K K  V     +   +  +PK     KGK    K       +
Sbjct: 234  PEKAK---SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 290

Query: 1549 NEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAES 1608
            +    +P  + +K  S  PK    +  S  ++   +   E         A KE K   + 
Sbjct: 291  SPVSKSPVEEKAK--SPVPKSPVEEAKSKAEVGKGEQKEEEEK--EVKEAPKEEKVEKKE 346

Query: 1609 DEEED 1613
            ++ +D
Sbjct: 347  EKPKD 351


>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
            [Homo sapiens]
          Length = 651

 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 89/420 (21%), Positives = 162/420 (38%), Gaps = 69/420 (16%)

Query: 1231 SPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSV 1290
            +P  ++I+ E T  + +A K  LK    +  +   K         +  E   E   + +V
Sbjct: 141  NPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSK---------SSSETNPESQNSKTV 191

Query: 1291 PINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDD---ESKSESDLE----- 1342
              N   K K++ K   ++   T     K + KK  KR+  S+D   E  SE+ L      
Sbjct: 192  SKNCSQKDKKDSKN--SKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLM 249

Query: 1343 ---ETEPVVIPRDSLLRRAAAERPK-YTFDFSE----------EEDDDADDDDDDNNDLE 1388
               +++   I  D+ LR  +    K Y+  +++          ++  DA+ +D  +   +
Sbjct: 250  LVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKD 309

Query: 1389 ELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSY 1448
              KVK + +  D + + V  D    D  +   G SK   + +  DKK             
Sbjct: 310  SKKVKKN-VKKDDKKKDVKKDTESTDAES---GDSKDERKDTKKDKKKLK---------- 355

Query: 1449 SQKSEDDSAKF----DSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKR 1504
                + D+ K+    D+   D+    + S  LK+  K   K   AKK   S+D+      
Sbjct: 356  KDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDS------ 409

Query: 1505 APKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTS 1564
                +  +E+  S  D +       T  K   +  ++   + SE +GD   G+K  K   
Sbjct: 410  ----ESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGK 465

Query: 1565 KKPKKTSFDQDSDVDIFPSDFPTE-------PPSLPRTGRARKEVKYFAESDEEEDDVDF 1617
            K  KK    +D+  +   ++  ++         S  + G ++K++K  A  D E  D +F
Sbjct: 466  KDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKG-SKKDIKKDARKDTESTDAEF 524


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 79/411 (19%), Positives = 161/411 (39%), Gaps = 53/411 (12%)

Query: 1171 LKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMP 1230
            L +K   ++  E     +E++ +  S E+   +     K  + K+ K K   LQ  E  P
Sbjct: 1156 LVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQ--EKKP 1213

Query: 1231 SPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSV 1290
             P  +++IPE   ++++  K LL++KK    T   K    E  + AP E    + L   V
Sbjct: 1214 LPEEKKLIPEEEKIRSEEKKPLLEEKK---PTPEDKKLLPEAKTSAP-EEQKHDLLKSQV 1269

Query: 1291 PINK-------GPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEE 1343
             I +        PK  +E K+P T++   P  SG P +          +D+  +++  E+
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLP--SGTPQSLP-------KEDDKTTKTIKEQ 1320

Query: 1344 TEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDN----NDLEELKVKASPITN 1399
             +P    +   +     +        +E+EDD +D            L +    +  I++
Sbjct: 1321 PQPPCTAKPDQVEPGKEK--------TEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISS 1372

Query: 1400 D-GE-DEFVPSD------GLDKDEYTFSPGKSKATP------EKSLHDKKSQDFGNLFSF 1445
              GE    +P+D      GL KD  +FS   S ++P      E ++          L   
Sbjct: 1373 SLGEIPSLIPTDEKDILKGLKKD--SFSQESSPSSPSDLAKLESTVLSILEAQASTLADE 1430

Query: 1446 PSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKG---KPSSDTVPKP 1502
             S  +    + +     +++     S +  +  +++   ++   +K    K S   +P  
Sbjct: 1431 KSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSS 1490

Query: 1503 KRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDY 1553
            K   ++ + V+ + +  +    + + + +        K+R + GS +  +Y
Sbjct: 1491 KDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEY 1541



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 59/265 (22%), Positives = 102/265 (38%), Gaps = 21/265 (7%)

Query: 1274 SGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDD 1333
            S  P + + ++   P   ++K P+PK+        + K PT  G PSAK   K+ P +D 
Sbjct: 676  SPQPQQTSPKKDAAPKQDLSKAPEPKKPPP-----LVKQPTLHGSPSAKA--KQPPEADS 728

Query: 1334 ESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVK 1393
             SK     E +    +P +      A ++PK         D  +        D+   KV+
Sbjct: 729  LSKPAPPKEPS----VPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQ 784

Query: 1394 ASPITNDGEDEFVPSDGLD--KDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQK 1451
            +       E++  P    D  K   +F P   K +P  S    +      + S P  S +
Sbjct: 785  SQ-----AEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSE 839

Query: 1452 SEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKG-KPSS-DTVPKPKRAPKQK 1509
            S+         +++           K   K   K      G +P++  TVP P+++PK +
Sbjct: 840  SKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQ 899

Query: 1510 KVVEAVNSDSDSEFGIPK-KTTTPK 1533
            +     + +  S    PK + TTP+
Sbjct: 900  EQSRRFSLNLGSITDAPKSQPTTPQ 924



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 95/494 (19%), Positives = 177/494 (35%), Gaps = 66/494 (13%)

Query: 1073 EKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWK---EAQEKAAEEDETQNQHDDSSSD 1129
            EK   K    +  +    Q L   GY SD + +      +     E+D  +    DS S 
Sbjct: 1340 EKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQ 1399

Query: 1130 SGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWK-----EDL 1184
              +PS P     L  ++ S+ + +   L  ++  K  + +++  + P D  K     E L
Sbjct: 1400 ESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETL 1459

Query: 1185 AAFVEELDKVESQ-EREDVLAGMSGKAI-KGKVGKPKVKKLQLEETMPSPYG-------- 1234
               + E +  ESQ ER+D     S + I   K  K K + +    T   PY         
Sbjct: 1460 EITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSES 1519

Query: 1235 -------RRIIPEITAMKADASKKLLKKKKGD----LDTAAVKVEFDEEFSGAPVEGAGE 1283
                   R+    + +  +D  K+   +  G+    +    +++  DE+ SG+  +    
Sbjct: 1520 ENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIR 1579

Query: 1284 EAL---TPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKS--- 1337
              L   + S    K  + K + K    + R+    S     +   +R+ W D++ ++   
Sbjct: 1580 NQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDE 1639

Query: 1338 -------ESDLEETEPVVIPRDSLLRR---------------AAAERPKYTFDFSEEEDD 1375
                   E+  +E+E +V+     LRR               A + + K +  F EE + 
Sbjct: 1640 SPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPEL 1699

Query: 1376 DADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKK 1435
            + +   D   D    +  +S   +       P+     DE + S    K    K     +
Sbjct: 1700 EMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKAR 1759

Query: 1436 SQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPS 1495
             +  G L   P+    SE++  +    EE+          ++Q  +  S    +KK K  
Sbjct: 1760 HRPHGPL--LPTIEDSSEEEELR---EEEELLKEQEKQREIEQQQRKSS----SKKSKKD 1810

Query: 1496 SDTVPKPKRAPKQK 1509
             D +   +R  + K
Sbjct: 1811 KDELRAQRRRERPK 1824


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 79/411 (19%), Positives = 161/411 (39%), Gaps = 53/411 (12%)

Query: 1171 LKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMP 1230
            L +K   ++  E     +E++ +  S E+   +     K  + K+ K K   LQ  E  P
Sbjct: 1156 LVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQ--EKKP 1213

Query: 1231 SPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSV 1290
             P  +++IPE   ++++  K LL++KK    T   K    E  + AP E    + L   V
Sbjct: 1214 LPEEKKLIPEEEKIRSEEKKPLLEEKK---PTPEDKKLLPEAKTSAP-EEQKHDLLKSQV 1269

Query: 1291 PINK-------GPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEE 1343
             I +        PK  +E K+P T++   P  SG P +          +D+  +++  E+
Sbjct: 1270 QIAEEKLEGRVAPKTVQEGKQPQTKMEGLP--SGTPQSLP-------KEDDKTTKTIKEQ 1320

Query: 1344 TEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDN----NDLEELKVKASPITN 1399
             +P    +   +     +        +E+EDD +D            L +    +  I++
Sbjct: 1321 PQPPCTAKPDQVEPGKEK--------TEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISS 1372

Query: 1400 D-GE-DEFVPSD------GLDKDEYTFSPGKSKATP------EKSLHDKKSQDFGNLFSF 1445
              GE    +P+D      GL KD  +FS   S ++P      E ++          L   
Sbjct: 1373 SLGEIPSLIPTDEKDILKGLKKD--SFSQESSPSSPSDLAKLESTVLSILEAQASTLADE 1430

Query: 1446 PSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKG---KPSSDTVPKP 1502
             S  +    + +     +++     S +  +  +++   ++   +K    K S   +P  
Sbjct: 1431 KSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSS 1490

Query: 1503 KRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDY 1553
            K   ++ + V+ + +  +    + + + +        K+R + GS +  +Y
Sbjct: 1491 KDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEY 1541



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 59/265 (22%), Positives = 102/265 (38%), Gaps = 21/265 (7%)

Query: 1274 SGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDD 1333
            S  P + + ++   P   ++K P+PK+        + K PT  G PSAK   K+ P +D 
Sbjct: 676  SPQPQQTSPKKDAAPKQDLSKAPEPKKPPP-----LVKQPTLHGSPSAKA--KQPPEADS 728

Query: 1334 ESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVK 1393
             SK     E +    +P +      A ++PK         D  +        D+   KV+
Sbjct: 729  LSKPAPPKEPS----VPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQ 784

Query: 1394 ASPITNDGEDEFVPSDGLD--KDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQK 1451
            +       E++  P    D  K   +F P   K +P  S    +      + S P  S +
Sbjct: 785  SQ-----AEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSE 839

Query: 1452 SEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKG-KPSS-DTVPKPKRAPKQK 1509
            S+         +++           K   K   K      G +P++  TVP P+++PK +
Sbjct: 840  SKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQ 899

Query: 1510 KVVEAVNSDSDSEFGIPK-KTTTPK 1533
            +     + +  S    PK + TTP+
Sbjct: 900  EQSRRFSLNLGSITDAPKSQPTTPQ 924



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 95/494 (19%), Positives = 177/494 (35%), Gaps = 66/494 (13%)

Query: 1073 EKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWK---EAQEKAAEEDETQNQHDDSSSD 1129
            EK   K    +  +    Q L   GY SD + +      +     E+D  +    DS S 
Sbjct: 1340 EKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQ 1399

Query: 1130 SGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWK-----EDL 1184
              +PS P     L  ++ S+ + +   L  ++  K  + +++  + P D  K     E L
Sbjct: 1400 ESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETL 1459

Query: 1185 AAFVEELDKVESQ-EREDVLAGMSGKAI-KGKVGKPKVKKLQLEETMPSPYG-------- 1234
               + E +  ESQ ER+D     S + I   K  K K + +    T   PY         
Sbjct: 1460 EITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSES 1519

Query: 1235 -------RRIIPEITAMKADASKKLLKKKKGD----LDTAAVKVEFDEEFSGAPVEGAGE 1283
                   R+    + +  +D  K+   +  G+    +    +++  DE+ SG+  +    
Sbjct: 1520 ENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIR 1579

Query: 1284 EAL---TPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKS--- 1337
              L   + S    K  + K + K    + R+    S     +   +R+ W D++ ++   
Sbjct: 1580 NQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDE 1639

Query: 1338 -------ESDLEETEPVVIPRDSLLRR---------------AAAERPKYTFDFSEEEDD 1375
                   E+  +E+E +V+     LRR               A + + K +  F EE + 
Sbjct: 1640 SPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPEL 1699

Query: 1376 DADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKK 1435
            + +   D   D    +  +S   +       P+     DE + S    K    K     +
Sbjct: 1700 EMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKAR 1759

Query: 1436 SQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPS 1495
             +  G L   P+    SE++  +    EE+          ++Q  +  S    +KK K  
Sbjct: 1760 HRPHGPL--LPTIEDSSEEEELR---EEEELLKEQEKQREIEQQQRKSS----SKKSKKD 1810

Query: 1496 SDTVPKPKRAPKQK 1509
             D +   +R  + K
Sbjct: 1811 KDELRAQRRRERPK 1824


>gi|54112403 chromodomain helicase DNA binding protein 7 [Homo
            sapiens]
          Length = 2997

 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 54/183 (29%), Positives = 74/183 (40%), Gaps = 28/183 (15%)

Query: 1452 SEDDSAKFDSNE----EDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPK 1507
            +ED S  F  ++     D+  +   S    Q +K   K   AKK  P     PK K+ PK
Sbjct: 608  AEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKRSKAKKD-PKEPKEPKEKKEPK 666

Query: 1508 QKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKP 1567
            + K  +A          IPK+    K K    K + +  S N+    P  + S    K  
Sbjct: 667  EPKTPKAPK--------IPKEPKEKKAKTATPKPKSSKKSSNK---KPDSEASALKKKVN 715

Query: 1568 K-KTSFDQDSDVDIFPSDFP----TEPPSLP--RTGRARKEVKY-----FAESDEEEDDV 1615
            K KT   ++SD+D  P   P     E P +   R+ R  K  +Y     F  SDEE DD 
Sbjct: 716  KGKTEGSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDA 775

Query: 1616 DFA 1618
            D A
Sbjct: 776  DAA 778



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 49/159 (30%), Positives = 67/159 (42%), Gaps = 30/159 (18%)

Query: 1240 EITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPK-P 1298
            E+     D S++  KKKK        K + D +    P E   +E   P  P  K PK P
Sbjct: 628  ELNRNSLDGSQEEKKKKKRS------KAKKDPKEPKEPKEK--KEPKEPKTP--KAPKIP 677

Query: 1299 KREKKEPGTRVRKTPTSSGKPSAKK-------VKKRNPWSDDESKSESDLEETEPVVIPR 1351
            K  K++        P SS K S KK       +KK+      E    SDL++T P   P 
Sbjct: 678  KEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPPP 737

Query: 1352 DS------LLRRAA--AERPKYT----FDFSEEEDDDAD 1378
            +         RR++   +R +YT    F  S+EE DDAD
Sbjct: 738  EEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDAD 776


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.132    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,797,122
Number of Sequences: 37866
Number of extensions: 3054302
Number of successful extensions: 15442
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 408
Number of HSP's that attempted gapping in prelim test: 12655
Number of HSP's gapped (non-prelim): 2074
length of query: 1621
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1505
effective length of database: 13,855,062
effective search space: 20851868310
effective search space used: 20851868310
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press