Search of human proteins with 19743808

Search of human proteins with 19743808

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo
sapiens]
         (317 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]   645   0.0  
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                  436   e-122
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...   329   2e-90
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...   314   7e-86
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo...   296   2e-80
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom...   296   2e-80
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom...   296   2e-80
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo...   296   2e-80
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...   193   1e-49
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...   193   1e-49
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...   193   1e-49
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]    161   6e-40
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi...   156   2e-38
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    94   2e-19
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    77   2e-14
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          72   6e-13
gi|186928839 retinol dehydrogenase 12 [Homo sapiens]                   70   2e-12
gi|40254992 carbonic reductase 4 [Homo sapiens]                        70   2e-12
gi|166795268 retinol dehydrogenase 11 [Homo sapiens]                   69   5e-12
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    69   7e-12
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         67   2e-11
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      66   5e-11
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       66   5e-11
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    65   8e-11
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    65   8e-11
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    64   1e-10
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           62   5e-10
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    61   1e-09
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo...    59   4e-09
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]            59   7e-09

>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score =  645 bits (1663), Expect = 0.0
 Identities = 317/317 (100%), Positives = 317/317 (100%)

Query: 1   MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 60
           MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC
Sbjct: 1   MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 60

Query: 61  LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 120
           LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT
Sbjct: 61  LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 120

Query: 121 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 180
           LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK
Sbjct: 121 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 180

Query: 181 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 240
           YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ
Sbjct: 181 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 240

Query: 241 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 300
           QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS
Sbjct: 241 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 300

Query: 301 LADYILTRSWPKPAQAV 317
           LADYILTRSWPKPAQAV
Sbjct: 301 LADYILTRSWPKPAQAV 317


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score =  436 bits (1120), Expect = e-122
 Identities = 210/317 (66%), Positives = 255/317 (80%)

Query: 1   MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 60
           MWLYLA FVGLYYLLHWYRERQV+SHL+DKYVFITGCDSGFG LLARQLDARGLRVLAAC
Sbjct: 1   MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAAC 60

Query: 61  LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 120
           LTEKGAEQLRGQTSDRLETVTLDVTK ES+AAA QWVKE V D+GLWGLVNNAGI  P  
Sbjct: 61  LTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTA 120

Query: 121 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 180
             E L  +D + +L VNL+GVI VTLS+LPLVRRARGR+VNVSS++GRV+ F GGYC+SK
Sbjct: 121 PNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISK 180

Query: 181 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQ 240
           YGVEAFSD LRRE+ +FGVK++++EPGYF+T +T+  + L+   + W  +   +KE YG+
Sbjct: 181 YGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGE 240

Query: 241 QYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTS 300
           ++        ++    C+ +L+LVT+CMEHAL + HPRTRYSAGWDAK  ++P+SY+PT 
Sbjct: 241 KFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTF 300

Query: 301 LADYILTRSWPKPAQAV 317
           L D I+    P PA+A+
Sbjct: 301 LVDAIMYWVSPSPAKAL 317


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score =  329 bits (843), Expect = 2e-90
 Identities = 159/313 (50%), Positives = 222/313 (70%)

Query: 5   LAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEK 64
           +AA   L ++  W++   +V +L +KYVFITGCDSGFGNLLA+QL  RG++VLAAC TE+
Sbjct: 1   MAALTDLSFMYRWFKNCNLVGNLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE 60

Query: 65  GAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEW 124
           G+++L+  TS RL+T  LDVTK ESI AA QWV++ VG++GLW LVNNAG+  P    EW
Sbjct: 61  GSQKLQRDTSYRLQTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEW 120

Query: 125 LNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVE 184
           L  +D + ++ VNL+G+I+VTL MLP+V+RARGR+VN+SS  GRVA   GGYCVSK+GVE
Sbjct: 121 LTKDDFVKVINVNLVGLIEVTLHMLPMVKRARGRVVNMSSSGGRVAVIGGGYCVSKFGVE 180

Query: 185 AFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFD 244
           AFSD +RRE+ +FGVK+ I+EPG +RT +        RM++ W+  P+  +++YG+ YF 
Sbjct: 181 AFSDSIRRELYYFGVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQETRDSYGEDYFR 240

Query: 245 ALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADY 304
              + +K  +      +  V + MEHA+ S  PR RY+ G DAK  +IPL+ LPT + D+
Sbjct: 241 IYTDKLKNIMQVAEPRVRDVINSMEHAIVSRSPRIRYNPGLDAKLLYIPLAKLPTPVTDF 300

Query: 305 ILTRSWPKPAQAV 317
           IL+R  P+PA +V
Sbjct: 301 ILSRYLPRPADSV 313


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score =  314 bits (804), Expect = 7e-86
 Identities = 165/320 (51%), Positives = 221/320 (69%), Gaps = 6/320 (1%)

Query: 1   MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAAC 60
           MWL L     L+ +L   R+RQ +    + +VFITGCDSGFG LLA QLD RG RVLA+C
Sbjct: 1   MWLPLLLGALLWAVLWLLRDRQSLP-ASNAFVFITGCDSGFGRLLALQLDQRGFRVLASC 59

Query: 61  LTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPIT 120
           LT  GAE L+   S RL T  LD+T  +S+  A +WV+ HV + GL+GLVNNAG+   I 
Sbjct: 60  LTPSGAEDLQRVASSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIG 119

Query: 121 LCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSK 180
              WL  +D   +L VN +G I VTL++LPL+++ARGR++N++S+LGR+A   GGYCVSK
Sbjct: 120 PTPWLTRDDFQRVLNVNTMGPIGVTLALLPLLQQARGRVINITSVLGRLAANGGGYCVSK 179

Query: 181 YGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQS-WKEAPKHIKETYG 239
           +G+EAFSD LRR++ HFG+++SIVEPG+FRT +TN+ +SLE+  Q+ W   P   +  YG
Sbjct: 180 FGLEAFSDSLRRDVAHFGIRVSIVEPGFFRTPVTNL-ESLEKTLQACWARLPPATQAHYG 238

Query: 240 QQYFDALYNIMKEGLLN--CSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYL 297
             +    Y  M++ ++N  C  +L  V+ C+EHALT+ HPRTRYS GWDAK  ++P SYL
Sbjct: 239 GAFL-TKYLKMQQRIMNLICDPDLTKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYL 297

Query: 298 PTSLADYILTRSWPKPAQAV 317
           P SL D +LT   PKPAQAV
Sbjct: 298 PASLVDAVLTWVLPKPAQAV 317


>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  296 bits (758), Expect = 2e-80
 Identities = 139/293 (47%), Positives = 204/293 (69%), Gaps = 1/293 (0%)

Query: 17  WYRERQV-VSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75
           W R+ ++ +  + DKY+FITGCDSGFGNL AR  D +G  V+AACLTE G+  L+ +TS+
Sbjct: 16  WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75

Query: 76  RLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLK 135
           RL TV LDVT  E++    QWVK  VG++GLWGL+NNAG+   +   +WL  ED    ++
Sbjct: 76  RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135

Query: 136 VNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQ 195
           VNL G+I VTL+MLPLV++A+GR++NVSS+ GR+A   GGY  SKY VE F+D LRR+++
Sbjct: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195

Query: 196 HFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLL 255
            FGV +S +EPG F+T + +  + +E+    W++    IK+ YG+ Y +   + +K    
Sbjct: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255

Query: 256 NCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTR 308
             + +L+ V +CM+HALTS+ P+T Y+AG DAK F+IPLS++P +L D++L +
Sbjct: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLK 308


>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  296 bits (758), Expect = 2e-80
 Identities = 139/293 (47%), Positives = 204/293 (69%), Gaps = 1/293 (0%)

Query: 17  WYRERQV-VSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75
           W R+ ++ +  + DKY+FITGCDSGFGNL AR  D +G  V+AACLTE G+  L+ +TS+
Sbjct: 16  WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75

Query: 76  RLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLK 135
           RL TV LDVT  E++    QWVK  VG++GLWGL+NNAG+   +   +WL  ED    ++
Sbjct: 76  RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135

Query: 136 VNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQ 195
           VNL G+I VTL+MLPLV++A+GR++NVSS+ GR+A   GGY  SKY VE F+D LRR+++
Sbjct: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195

Query: 196 HFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLL 255
            FGV +S +EPG F+T + +  + +E+    W++    IK+ YG+ Y +   + +K    
Sbjct: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255

Query: 256 NCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTR 308
             + +L+ V +CM+HALTS+ P+T Y+AG DAK F+IPLS++P +L D++L +
Sbjct: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLK 308


>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  296 bits (758), Expect = 2e-80
 Identities = 139/293 (47%), Positives = 204/293 (69%), Gaps = 1/293 (0%)

Query: 17  WYRERQV-VSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75
           W R+ ++ +  + DKY+FITGCDSGFGNL AR  D +G  V+AACLTE G+  L+ +TS+
Sbjct: 16  WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75

Query: 76  RLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLK 135
           RL TV LDVT  E++    QWVK  VG++GLWGL+NNAG+   +   +WL  ED    ++
Sbjct: 76  RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135

Query: 136 VNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQ 195
           VNL G+I VTL+MLPLV++A+GR++NVSS+ GR+A   GGY  SKY VE F+D LRR+++
Sbjct: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195

Query: 196 HFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLL 255
            FGV +S +EPG F+T + +  + +E+    W++    IK+ YG+ Y +   + +K    
Sbjct: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255

Query: 256 NCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTR 308
             + +L+ V +CM+HALTS+ P+T Y+AG DAK F+IPLS++P +L D++L +
Sbjct: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLK 308


>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  296 bits (758), Expect = 2e-80
 Identities = 139/293 (47%), Positives = 204/293 (69%), Gaps = 1/293 (0%)

Query: 17  WYRERQV-VSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSD 75
           W R+ ++ +  + DKY+FITGCDSGFGNL AR  D +G  V+AACLTE G+  L+ +TS+
Sbjct: 16  WTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSE 75

Query: 76  RLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLK 135
           RL TV LDVT  E++    QWVK  VG++GLWGL+NNAG+   +   +WL  ED    ++
Sbjct: 76  RLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIE 135

Query: 136 VNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQ 195
           VNL G+I VTL+MLPLV++A+GR++NVSS+ GR+A   GGY  SKY VE F+D LRR+++
Sbjct: 136 VNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMK 195

Query: 196 HFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLL 255
            FGV +S +EPG F+T + +  + +E+    W++    IK+ YG+ Y +   + +K    
Sbjct: 196 AFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKS 255

Query: 256 NCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTR 308
             + +L+ V +CM+HALTS+ P+T Y+AG DAK F+IPLS++P +L D++L +
Sbjct: 256 YVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLK 308


>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score =  193 bits (491), Expect = 1e-49
 Identities = 117/291 (40%), Positives = 173/291 (59%), Gaps = 15/291 (5%)

Query: 30  KYVFITGCDSGFGNLLARQLDARGLRVLAACLTEK----GAEQLRGQTSDRLETVTLDVT 85
           K V +TGCDSGFG  LA+ L ++G  V A CL +     G ++L    SDRL TV L+V 
Sbjct: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115

Query: 86  KMESIAAATQWVKEHVGD--RGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQ 143
             E +    + V+  + D  +G+WGLVNNAGI T     E+ + E    + +VNL G ++
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWGTVR 174

Query: 144 VTLSMLPLVRRARGRIVNVSSILGRVAFFV-GGYCVSKYGVEAFSDILRREIQHFGVKIS 202
           +T S LPL+RRA+GR+VN+SS+LGR+A      YC++K+GVEAFSD LR E+   GVK+S
Sbjct: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234

Query: 203 IVEPGYF--RTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTN 260
           +VEPG F   T + +        K+ W+E P+ +++ YG++YFD     M+    + ST+
Sbjct: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTD 294

Query: 261 LNLVTDCMEHALTSVHPRTRY---SAGWDAKFFFIPLSYLPTSLADYILTR 308
            + V D + HALT+  P TRY      W  +     +++LP +++D I  R
Sbjct: 295 TSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQI--MTHLPGAISDMIYIR 343


>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score =  193 bits (491), Expect = 1e-49
 Identities = 117/291 (40%), Positives = 173/291 (59%), Gaps = 15/291 (5%)

Query: 30  KYVFITGCDSGFGNLLARQLDARGLRVLAACLTEK----GAEQLRGQTSDRLETVTLDVT 85
           K V +TGCDSGFG  LA+ L ++G  V A CL +     G ++L    SDRL TV L+V 
Sbjct: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115

Query: 86  KMESIAAATQWVKEHVGD--RGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQ 143
             E +    + V+  + D  +G+WGLVNNAGI T     E+ + E    + +VNL G ++
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWGTVR 174

Query: 144 VTLSMLPLVRRARGRIVNVSSILGRVAFFV-GGYCVSKYGVEAFSDILRREIQHFGVKIS 202
           +T S LPL+RRA+GR+VN+SS+LGR+A      YC++K+GVEAFSD LR E+   GVK+S
Sbjct: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234

Query: 203 IVEPGYF--RTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTN 260
           +VEPG F   T + +        K+ W+E P+ +++ YG++YFD     M+    + ST+
Sbjct: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTD 294

Query: 261 LNLVTDCMEHALTSVHPRTRY---SAGWDAKFFFIPLSYLPTSLADYILTR 308
            + V D + HALT+  P TRY      W  +     +++LP +++D I  R
Sbjct: 295 TSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQI--MTHLPGAISDMIYIR 343


>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score =  193 bits (491), Expect = 1e-49
 Identities = 117/291 (40%), Positives = 173/291 (59%), Gaps = 15/291 (5%)

Query: 30  KYVFITGCDSGFGNLLARQLDARGLRVLAACLTEK----GAEQLRGQTSDRLETVTLDVT 85
           K V +TGCDSGFG  LA+ L ++G  V A CL +     G ++L    SDRL TV L+V 
Sbjct: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115

Query: 86  KMESIAAATQWVKEHVGD--RGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQ 143
             E +    + V+  + D  +G+WGLVNNAGI T     E+ + E    + +VNL G ++
Sbjct: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWGTVR 174

Query: 144 VTLSMLPLVRRARGRIVNVSSILGRVAFFV-GGYCVSKYGVEAFSDILRREIQHFGVKIS 202
           +T S LPL+RRA+GR+VN+SS+LGR+A      YC++K+GVEAFSD LR E+   GVK+S
Sbjct: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234

Query: 203 IVEPGYF--RTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTN 260
           +VEPG F   T + +        K+ W+E P+ +++ YG++YFD     M+    + ST+
Sbjct: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTD 294

Query: 261 LNLVTDCMEHALTSVHPRTRY---SAGWDAKFFFIPLSYLPTSLADYILTR 308
            + V D + HALT+  P TRY      W  +     +++LP +++D I  R
Sbjct: 295 TSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQI--MTHLPGAISDMIYIR 343


>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
          Length = 387

 Score =  161 bits (408), Expect = 6e-40
 Identities = 108/318 (33%), Positives = 162/318 (50%), Gaps = 14/318 (4%)

Query: 3   LYLAAFVGLY------YLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRV 56
           L L+ F GL       +L++ Y   Q +  +  K V +TG D G G+ L + LD  G  V
Sbjct: 50  LILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTV 109

Query: 57  LAACLTEKG--AEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAG 114
            A  L E G  AE+LR   S RL  + +D+TK   I  A   V   + DRGLW ++NNAG
Sbjct: 110 FAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAG 169

Query: 115 ILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAF-FV 173
           +L   T  E L   D    + VN  G ++VT + LPL+R+++GR+VNVSS+ G      +
Sbjct: 170 VLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERL 229

Query: 174 GGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERM-KQSWKEAPK 232
             Y  SK  V  FS ++R E+  +G+K++ ++PG F T +   +   E++ K      P 
Sbjct: 230 ASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPA 289

Query: 233 HIKETYGQQYFDALYNIMKEGLLN--CSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFF 290
            ++E YGQ Y  A  N +   L+N   S + + V   ++HA+ +  P   Y+ G  A  +
Sbjct: 290 EVQEDYGQDYILAQRNFLL--LINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLW 347

Query: 291 FIPLSYLPTSLADYILTR 308
                YLP  + DY   R
Sbjct: 348 ICLAHYLPIGIYDYFAKR 365


>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
           sapiens]
          Length = 405

 Score =  156 bits (395), Expect = 2e-38
 Identities = 97/274 (35%), Positives = 141/274 (51%), Gaps = 4/274 (1%)

Query: 32  VFITGCDSGFGNLLARQLDARGLRVLAACL--TEKGAEQLRGQTSDRLETVTLDVTKMES 89
           V ITGCDSGFG   A++LD+ G  VLA  L     GA +LR   S RL  + +D+TK   
Sbjct: 85  VLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGD 144

Query: 90  IAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSML 149
           I+   ++ K H    GLWGLVNNAG    +   E        + ++VN  G +++T  +L
Sbjct: 145 ISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLL 204

Query: 150 PLVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGY 208
           PL+R +RGRIV V S  G + +  +G Y  SK  V    D    E+  +GVK+SI++PG 
Sbjct: 205 PLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGC 264

Query: 209 FRT-GMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDC 267
           F+T  + N+ Q  +R +      P+ + + YG+ Y + L+      L    ++L  V D 
Sbjct: 265 FKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDA 324

Query: 268 MEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSL 301
           +  AL +  PR RY  G      +    YLP  L
Sbjct: 325 ITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGL 358


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 67/217 (30%), Positives = 115/217 (52%), Gaps = 19/217 (8%)

Query: 10  GLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGA--- 66
           GL+ LL W R +   ++L++  V ITG  SG G   A+   A G + L  C    GA   
Sbjct: 36  GLFRLLQWVRGK---AYLRNAVVVITGATSGLGKECAKVFYAAGAK-LVLCGRNGGALEE 91

Query: 67  --EQLRGQTSDRLET-----VTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPI 119
              +L    + +++T     VT D+T   +I AA   + +  G   +  LVNNAGI    
Sbjct: 92  LIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDI--LVNNAGISYRG 149

Query: 120 TLCEWLNTEDSMNMLKVNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVAF-FVGGYC 177
           T+ +     D   +++ N  G + +T ++LP +++R +G IV +SSI G+++  F   Y 
Sbjct: 150 TIMDTTVDVDK-RVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYA 208

Query: 178 VSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMT 214
            SK+  +AF D LR E++ + ++++++ PGY  T ++
Sbjct: 209 ASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLS 245


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 62/214 (28%), Positives = 112/214 (52%), Gaps = 13/214 (6%)

Query: 4   YLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTE 63
           +L A   L  L   ++ R+    L D  V++TG  SG G  LA QL   G+ ++ +    
Sbjct: 25  FLRADGDLTLLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAYQLSKLGVSLVLSARRV 84

Query: 64  KGAEQLRGQTSDR-------LETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGIL 116
              E+++ +  +        +  + LD+T   S  AAT+ V +  G   +  LVNN G +
Sbjct: 85  HELERVKRRCLENGNLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDI--LVNNGG-M 141

Query: 117 TPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVAFFVG- 174
           +  +LC   + +    ++++N +G + +T  +LP ++ R +G+IV V+SILG ++  +  
Sbjct: 142 SQRSLCMDTSLDVYRKLIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSI 201

Query: 175 GYCVSKYGVEAFSDILRREIQHF-GVKISIVEPG 207
           GYC SK+ +  F + LR E+  + G+ +S + PG
Sbjct: 202 GYCASKHALRGFFNGLRTELATYPGIIVSNICPG 235


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 80/262 (30%), Positives = 121/262 (46%), Gaps = 28/262 (10%)

Query: 32  VFITGCDSGFGNLLARQL--DARGLRVLAACLTEKGA-EQLRGQTSDRL-ETVT---LDV 84
           V I+GC SG G  LA QL  D +    + A + + G  E L     + L +T+T   LDV
Sbjct: 8   VLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDV 67

Query: 85  TKMESIAAATQWVKEHVGDRGLWGLVNNAG--ILTPITLCEWLNTEDSMNMLKVNLIGVI 142
              ES+A     ++  V       LVNNAG  ++ P+   E L+     N+   N  G +
Sbjct: 68  CSDESVAQCLSCIQGEVDV-----LVNNAGMGLVGPL---EGLSLAAMQNVFDTNFFGAV 119

Query: 143 QVTLSMLP-LVRRARGRIVNVSSILG-RVAFFVGGYCVSKYGVEAFSDILRREIQHFGVK 200
           ++  ++LP + RR +G IV +SS++G +   F   Y  SK+ +E F + L  ++  F + 
Sbjct: 120 RLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIF 179

Query: 201 ISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTN 260
           IS+VEPG   T       +    + S  E P    ET    YF  LY +     L CS  
Sbjct: 180 ISLVEPGPVVTEFEGKLLA----QVSMAEFPGTDPETL--HYFRDLY-LPASRKLFCSVG 232

Query: 261 LNL--VTDCMEHALTSVHPRTR 280
            N   V   + + ++S  P  R
Sbjct: 233 QNPQDVVQAIVNVISSTRPPLR 254


>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
          Length = 316

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 84/275 (30%), Positives = 128/275 (46%), Gaps = 37/275 (13%)

Query: 27  LQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLT----EKGAEQLRGQTSDRLETV-T 81
           L  K V ITG ++G G   AR+L +RG RV  AC      E  A ++R  T +    V  
Sbjct: 37  LPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRK 96

Query: 82  LDVTKMESIAA-ATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNM-LKVNLI 139
           LD++  +SI A A  ++ E   ++ L  L+NNAG++    +C +  T D     L VN +
Sbjct: 97  LDLSDTKSIRAFAEGFLAE---EKQLHILINNAGVM----MCPYSKTADGFETHLGVNHL 149

Query: 140 GVIQVTLSMLPLVR-RARGRIVNVSSI---LGRVAF--------FVGG--YCVSKYGVEA 185
           G   +T  +L  ++  A  R+VNVSS+   +G++ F        +  G  YC SK     
Sbjct: 150 GHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVL 209

Query: 186 FSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDA 245
           F+  L + +Q  GV    V PG  R+ +   +  L  + + +    K  +E  G Q   +
Sbjct: 210 FTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTARE--GAQ--TS 265

Query: 246 LYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTR 280
           L+  + EGL   S      +DC     T V PR R
Sbjct: 266 LHCALAEGLEPLSG--KYFSDCKR---TWVSPRAR 295


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 70.1 bits (170), Expect = 2e-12
 Identities = 53/188 (28%), Positives = 89/188 (47%), Gaps = 5/188 (2%)

Query: 29  DKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKME 88
           DK   + G   G G  +A+ +  +G R+       +GA+   G         + DV K  
Sbjct: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEH 61

Query: 89  SIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIG-VIQVTLS 147
            +    + +++H+G      LVN AGI     L     TED ++ L  NL+G ++    +
Sbjct: 62  DVQNTFEELEKHLGRVNF--LVNAAGINRDGLLVR-TKTEDMVSQLHTNLLGSMLTCKAA 118

Query: 148 MLPLVRRARGRIVNVSSILG-RVAFFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEP 206
           M  ++++  G IVNV SI+G +       Y  SK G+  FS  L +E+    +++++V P
Sbjct: 119 MRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAP 178

Query: 207 GYFRTGMT 214
           G+  T MT
Sbjct: 179 GFVHTDMT 186


>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
          Length = 318

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 82/255 (32%), Positives = 122/255 (47%), Gaps = 32/255 (12%)

Query: 27  LQDKYVFITGCDSGFGNLLARQLDARGLRVLAACL-TEKG---AEQLRGQTSDRLETV-T 81
           L  K V +TG ++G G   A++L  RG RV  AC   EKG   A++++  T ++   V  
Sbjct: 39  LPGKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRK 98

Query: 82  LDVTKMESIAA-ATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNM-LKVNLI 139
           LD++  +SI A A  ++ E   ++ L  L+NNAG++    +C +  T D   M + VN +
Sbjct: 99  LDLSDTKSIRAFAKGFLAE---EKHLHVLINNAGVM----MCPYSKTADGFEMHIGVNHL 151

Query: 140 GVIQVT-LSMLPLVRRARGRIVNVSSI---LGRV--------AFFVGG--YCVSKYGVEA 185
           G   +T L +  L   A  RIVNVSS+   LGR+         F+  G  YC SK     
Sbjct: 152 GHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANIL 211

Query: 186 FSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDA 245
           F+  L R ++  GV    V PG   T  + + +    M+  W      IK T  Q    +
Sbjct: 212 FTQELARRLKGSGVTTYSVHPG---TVQSELVRHSSFMRWMWWLFSFFIK-TPQQGAQTS 267

Query: 246 LYNIMKEGLLNCSTN 260
           L+  + EGL   S N
Sbjct: 268 LHCALTEGLEILSGN 282


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 77/266 (28%), Positives = 121/266 (45%), Gaps = 33/266 (12%)

Query: 32  VFITGCDSGFGNLLARQL---DARGLRVLAAC--LTEKG----AEQLRGQTSDRLETVTL 82
           V ITGC SG G  LA +L    ++  +V A    L  +G    A +        LET+ L
Sbjct: 6   VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65

Query: 83  DVTKMESIAAATQWVKEHVGDRGLWGLVNNAGI--LTPITLCEWLNTEDSMNMLKVNLIG 140
           DV   +S+AAA + V E   D     LV NAG+  L P+   E L  +   ++L VN++G
Sbjct: 66  DVRDSKSVAAARERVTEGRVDV----LVCNAGLGLLGPL---EALGEDAVASVLDVNVVG 118

Query: 141 VIQVTLSMLP-LVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREIQHFG 198
            +++  + LP + RR  GR++   S+ G +   F   YC SK+ +E   + L   +  FG
Sbjct: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178

Query: 199 VKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIM---KEGLL 255
           V +S++E G   T        +E++  S    P+ + +      F   Y  +   K+   
Sbjct: 179 VHLSLIECGPVHTAF------MEKVLGS----PEEVLDRTDIHTFHRFYQYLAHSKQVFR 228

Query: 256 NCSTNLNLVTDCMEHALTSVHPRTRY 281
             + N   V +    AL +  P  RY
Sbjct: 229 EAAQNPEEVAEVFLTALRAPKPTLRY 254


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 60/209 (28%), Positives = 96/209 (45%), Gaps = 27/209 (12%)

Query: 30  KYVFITGCDSGFGNLLARQLDARGLRVLAACLT----EKGAEQLRGQT-SDRLETVTLDV 84
           K V +TG ++G G   A +L  RG  ++ AC      E  A+ +RG+T +  +    LD+
Sbjct: 39  KTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLDL 98

Query: 85  TKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNM-LKVNLIGVIQ 143
             ++SI      + E   +  +  L+NNAG++     C    TED   M   VN +G   
Sbjct: 99  ASLKSIREFAAKIIEE--EERVDILINNAGVMR----CPHWTTEDGFEMQFGVNHLGHFL 152

Query: 144 VTLSMLPLVRR-ARGRIVNVSS---ILGRVAF-----------FVGGYCVSKYGVEAFSD 188
           +T  +L  ++  A  RI+N+SS   + G + F               YC SK  +  F+ 
Sbjct: 153 LTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTK 212

Query: 189 ILRREIQHFGVKISIVEPGYFRTGMTNMT 217
            L R +Q  GV ++ + PG  RT +   T
Sbjct: 213 ELSRRLQGSGVTVNALHPGVARTELGRHT 241


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 59/211 (27%), Positives = 99/211 (46%), Gaps = 18/211 (8%)

Query: 4   YLAAFVGLYYLLHWYRERQVV--SHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACL 61
           YL   +GL+   ++Y   +      LQ K V +TG   G G  +A  L   G  V+   +
Sbjct: 7   YLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVV---V 63

Query: 62  TEKGAEQLRGQTSDRLETVTLDVT----KMESIAAATQWVKEHVGDRGLWGLVNNAGILT 117
           T +  E L+   S  LE            ME +  A Q+V +    + + GL  +  IL 
Sbjct: 64  TARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQ--AGKLMGGL--DMLILN 119

Query: 118 PITLCEWLNTEDSMN----MLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAF-F 172
            IT        D ++     ++VN +  + +T++ LP+++++ G IV VSS+ G+VA+  
Sbjct: 120 HITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPM 179

Query: 173 VGGYCVSKYGVEAFSDILRREIQHFGVKISI 203
           V  Y  SK+ ++ F   +R+E     V +SI
Sbjct: 180 VAAYSASKFALDGFFSSIRKEYSVSRVNVSI 210


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 59/211 (27%), Positives = 99/211 (46%), Gaps = 18/211 (8%)

Query: 4   YLAAFVGLYYLLHWYRERQVV--SHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACL 61
           YL   +GL+   ++Y   +      LQ K V +TG   G G  +A  L   G  V+   +
Sbjct: 7   YLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVV---V 63

Query: 62  TEKGAEQLRGQTSDRLETVTLDVT----KMESIAAATQWVKEHVGDRGLWGLVNNAGILT 117
           T +  E L+   S  LE            ME +  A Q+V +    + + GL  +  IL 
Sbjct: 64  TARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQ--AGKLMGGL--DMLILN 119

Query: 118 PITLCEWLNTEDSMN----MLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAF-F 172
            IT        D ++     ++VN +  + +T++ LP+++++ G IV VSS+ G+VA+  
Sbjct: 120 HITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPM 179

Query: 173 VGGYCVSKYGVEAFSDILRREIQHFGVKISI 203
           V  Y  SK+ ++ F   +R+E     V +SI
Sbjct: 180 VAAYSASKFALDGFFSSIRKEYSVSRVNVSI 210


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 24/223 (10%)

Query: 26  HLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLET-----V 80
           H+  K   +TG   G G   A  L  +G +V       +   Q +    ++ E      +
Sbjct: 2   HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFI 61

Query: 81  TLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIG 140
             DV   + +    + V +H G   +  LVNNAG+          N ++    L++NL+ 
Sbjct: 62  QCDVADQQQLRDTFRKVVDHFGRLDI--LVNNAGV---------NNEKNWEKTLQINLVS 110

Query: 141 VIQVTLSMLPLVRRARGR----IVNVSSILGRVAFFVGG-YCVSKYGVEAF--SDILRRE 193
           VI  T   L  + +  G     I+N+SS+ G +       YC SK+G+  F  S  L   
Sbjct: 111 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 170

Query: 194 IQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKE 236
           + + GV+++ + PG+  T +    +  E M Q + E   HIK+
Sbjct: 171 LMNSGVRLNAICPGFVNTAILESIEKEENMGQ-YIEYKDHIKD 212


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 54/191 (28%), Positives = 87/191 (45%), Gaps = 11/191 (5%)

Query: 32  VFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETV---TLDVTKME 88
           V ITG   G G     +   R   ++   + ++G E+   +      T     +D +  E
Sbjct: 39  VLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNRE 98

Query: 89  SIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSM 148
            I  +   VK+ VGD  +  +VNNAG + P  L      E+     +VN++G   +T ++
Sbjct: 99  EIYRSLNQVKKEVGDVTI--VVNNAGTVYPADLLS-TKDEEITKTFEVNILGHFWITKAL 155

Query: 149 LP-LVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREIQHF---GVKISI 203
           LP ++ R  G IV V+S+ G     ++  YC SK+    F   L  E+Q     G+K S 
Sbjct: 156 LPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSC 215

Query: 204 VEPGYFRTGMT 214
           + P +  TG T
Sbjct: 216 LCPVFVNTGFT 226


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 47/179 (26%), Positives = 82/179 (45%), Gaps = 4/179 (2%)

Query: 30  KYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKMES 89
           K V +TG   G G  + R     G RV+     E G   L  +    +  +  DVT+ + 
Sbjct: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAV-FILCDVTQEDD 68

Query: 90  IAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSML 149
           +           G   L  +VNNAG   P    E  + +    +L++NL+G   +T   L
Sbjct: 69  VKTLVSETIRRFGR--LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLAL 126

Query: 150 PLVRRARGRIVNVSSILGRVAFFVG-GYCVSKYGVEAFSDILRREIQHFGVKISIVEPG 207
           P +R+++G ++N+SS++G +       Y  +K  V A +  L  +   +GV+++ + PG
Sbjct: 127 PYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPG 185


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 56/193 (29%), Positives = 91/193 (47%), Gaps = 16/193 (8%)

Query: 32  VFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQ----LRGQTSDRLETVTLDVTKM 87
           V ITG  SG G LLA Q    G  ++   + ++G E+     R   + R+   T D ++ 
Sbjct: 43  VLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQK 102

Query: 88  ESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSM--NMLKVNLIGVIQVT 145
           E +      VK+ VGD  +  L+NNAGI   +T  ++L+  D +      VN    +   
Sbjct: 103 EGVYRVADQVKKEVGDVSI--LINNAGI---VTGKKFLDCPDELMEKSFDVNFKAHLWTY 157

Query: 146 LSMLP-LVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREI---QHFGVK 200
            + LP ++    G +V +SS  G      +  YC SK+    F++ +  E    +  G+K
Sbjct: 158 KAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIK 217

Query: 201 ISIVEPGYFRTGM 213
            +IV P + +TGM
Sbjct: 218 TTIVCPFFIKTGM 230


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 61/222 (27%), Positives = 99/222 (44%), Gaps = 19/222 (8%)

Query: 3   LYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLT 62
           L L    GL ++          S +Q+K V IT   SG G   AR     G R++   L 
Sbjct: 11  LLLLGISGLLFIYQEVSRLWSKSAVQNKVVVITDAISGLGKECARVFHTGGARLV---LC 67

Query: 63  EKGAEQLRG------QTSDRLETVT-----LDVTKMESIAAATQWVKEHVGDRGLWGLVN 111
            K  E+L          +D  +T T     LD++ +  +    + V +  G   +  L+N
Sbjct: 68  GKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVLDCYGCVDI--LIN 125

Query: 112 NAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLP-LVRRARGRIVNVSSILGRVA 170
           NA +       + ++ E    ++  N  G I +T ++LP ++ R  G+IV V++I G+  
Sbjct: 126 NASVKVKGPAHK-ISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFG 184

Query: 171 F-FVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRT 211
             F   Y  SK+    F D LR E++ + V IS V P + R+
Sbjct: 185 IPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSPTFIRS 226


>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
           sapiens]
          Length = 336

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 63/220 (28%), Positives = 93/220 (42%), Gaps = 39/220 (17%)

Query: 27  LQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVT----- 81
           +  K V ITG +SG G   A +L   G RV+  C     AE+  GQ    L         
Sbjct: 41  MHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPE 100

Query: 82  -------------LDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTE 128
                        LD+  + S+ A  Q + +   +  L  L+NNAGI      C ++ TE
Sbjct: 101 PGVSGVGELIVRELDLASLRSVRAFCQEMLQE--EPRLDVLINNAGIFQ----CPYMKTE 154

Query: 129 DSMNM-LKVNLIGVIQVTLSMLPLVR-RARGRIVNVSSIL---GRVAF--------FVGG 175
           D   M   VN +G   +T  +L L++  A  RIV VSS L   G + F        +   
Sbjct: 155 DGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKS 214

Query: 176 YCV--SKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGM 213
           +C   SK     F+  L R ++   V ++++ PG  RT +
Sbjct: 215 FCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNL 254


>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
          Length = 310

 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 53/192 (27%), Positives = 90/192 (46%), Gaps = 11/192 (5%)

Query: 30  KYVFITGCDSGFGNLLARQLDARGLRVLAACLT----EKGAEQLRGQTSDRLETVTLDVT 85
           ++  ITG   G G   + +L  RGL V+    T    E  A ++   T   ++ +  D T
Sbjct: 49  QWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFT 108

Query: 86  KMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSM-NMLKVNLIGVIQV 144
           K +      + +KE +    +  LVNN G+L  +    +LN  D + +++  N+  V+++
Sbjct: 109 KDDIY----EHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKM 164

Query: 145 T-LSMLPLVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREIQHFGVKIS 202
           T L +  +  R +G I+N+SS +    +     Y  SK  V AFS  L+ E +   V I 
Sbjct: 165 TQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQ 224

Query: 203 IVEPGYFRTGMT 214
           ++ P    T MT
Sbjct: 225 VLTPYAVSTAMT 236


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,908,189
Number of Sequences: 37866
Number of extensions: 424847
Number of successful extensions: 1021
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 917
Number of HSP's gapped (non-prelim): 69
length of query: 317
length of database: 18,247,518
effective HSP length: 102
effective length of query: 215
effective length of database: 14,385,186
effective search space: 3092814990
effective search space used: 3092814990
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.