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Search of human proteins with 197304777
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197304777 TBC1 domain family, member 5 isoform a [Homo
sapiens]
(817 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens] 1632 0.0
gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens] 1578 0.0
gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens] 1578 0.0
gi|190014603 TBC1 domain family, member 13 [Homo sapiens] 113 8e-25
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi... 57 7e-08
gi|40068063 TBC1 domain family, member 22B [Homo sapiens] 57 9e-08
gi|22507409 TBC1 domain family, member 22A [Homo sapiens] 54 8e-07
gi|13375952 TBC1 domain family, member 17 [Homo sapiens] 52 3e-06
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens] 46 1e-04
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens] 46 1e-04
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens] 46 1e-04
gi|33563376 TBC1 domain family, member 16 [Homo sapiens] 45 2e-04
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 44 6e-04
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 44 8e-04
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 43 0.001
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 42 0.003
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa... 42 0.003
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa... 42 0.003
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap... 42 0.003
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap... 42 0.003
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 41 0.005
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 40 0.007
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 39 0.015
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 39 0.019
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 38 0.043
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 38 0.043
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 38 0.043
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 37 0.057
gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo sa... 37 0.057
gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo sa... 37 0.057
>gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]
Length = 817
Score = 1632 bits (4226), Expect = 0.0
Identities = 817/817 (100%), Positives = 817/817 (100%)
Query: 1 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60
MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
Sbjct: 1 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60
Query: 61 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120
ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
Sbjct: 61 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120
Query: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180
EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
Sbjct: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180
Query: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240
NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
Sbjct: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240
Query: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300
LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
Sbjct: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300
Query: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360
VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
Sbjct: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360
Query: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420
SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
Sbjct: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420
Query: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480
VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
Sbjct: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480
Query: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQV 540
PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQV
Sbjct: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQV 540
Query: 541 SVPVQTLTDLQGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT 600
SVPVQTLTDLQGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT
Sbjct: 541 SVPVQTLTDLQGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT 600
Query: 601 MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS 660
MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS
Sbjct: 601 MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS 660
Query: 661 LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ 720
LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ
Sbjct: 661 LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ 720
Query: 721 ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF 780
ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF
Sbjct: 721 ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF 780
Query: 781 SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI 817
SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI
Sbjct: 781 SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI 817
>gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens]
Length = 795
Score = 1578 bits (4086), Expect = 0.0
Identities = 795/817 (97%), Positives = 795/817 (97%), Gaps = 22/817 (2%)
Query: 1 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60
MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
Sbjct: 1 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60
Query: 61 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120
ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
Sbjct: 61 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120
Query: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180
EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
Sbjct: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180
Query: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240
NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
Sbjct: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240
Query: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300
LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
Sbjct: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300
Query: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360
VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
Sbjct: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360
Query: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420
SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
Sbjct: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420
Query: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480
VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
Sbjct: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480
Query: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQV 540
PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNK
Sbjct: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNK----------- 529
Query: 541 SVPVQTLTDLQGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT 600
GLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT
Sbjct: 530 -----------GLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT 578
Query: 601 MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS 660
MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS
Sbjct: 579 MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS 638
Query: 661 LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ 720
LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ
Sbjct: 639 LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ 698
Query: 721 ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF 780
ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF
Sbjct: 699 ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF 758
Query: 781 SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI 817
SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI
Sbjct: 759 SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI 795
>gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens]
Length = 795
Score = 1578 bits (4086), Expect = 0.0
Identities = 795/817 (97%), Positives = 795/817 (97%), Gaps = 22/817 (2%)
Query: 1 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60
MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
Sbjct: 1 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60
Query: 61 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120
ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
Sbjct: 61 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120
Query: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180
EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
Sbjct: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180
Query: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240
NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
Sbjct: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240
Query: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300
LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
Sbjct: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300
Query: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360
VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
Sbjct: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360
Query: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420
SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
Sbjct: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420
Query: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480
VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
Sbjct: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480
Query: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQV 540
PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNK
Sbjct: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNK----------- 529
Query: 541 SVPVQTLTDLQGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT 600
GLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT
Sbjct: 530 -----------GLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT 578
Query: 601 MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS 660
MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS
Sbjct: 579 MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS 638
Query: 661 LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ 720
LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ
Sbjct: 639 LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ 698
Query: 721 ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF 780
ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF
Sbjct: 699 ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF 758
Query: 781 SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI 817
SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI
Sbjct: 759 SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI 795
>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
Length = 400
Score = 113 bits (282), Expect = 8e-25
Identities = 101/386 (26%), Positives = 168/386 (43%), Gaps = 47/386 (12%)
Query: 69 LATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNP- 127
L +R+ +G R +CWK+ L LP +++ W S + + R Y+ I P
Sbjct: 23 LEKLRELSFSGIPCEGGLRCLCWKILLNYLPLERASWTSILAKQRELYAQFLREMIIQPG 82
Query: 128 ----RKVVGQQDLMI-NNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQ--- 179
V ++D+ ++PL+ + S WN +F+D E+ I++DV+R P++ FFQ+
Sbjct: 83 IAKANMGVSREDVTFEDHPLNPNPDSRWNTYFKDNEVLLQIDKDVRRLCPDISFFQRATD 142
Query: 180 -------------ENVRKILTDVLF---CYARENEQLLYKQGMHELLAPIVFVLHCDHQA 223
E +RK + AR + H+ P +++
Sbjct: 143 YPCLLILDPQNEFETLRKRVEQTTLKSQTVARNRSGVTNMSSPHKNSVPSSL---NEYEV 199
Query: 224 FLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHD-GQKGKE----- 277
+ E+ E ++ +L + A + E P + TF D + KE
Sbjct: 200 LPNGCEAHW--EVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEAD 257
Query: 278 ------TLMTPI--PFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQI 329
LM I F + D I K+ ++ L K D+ELY+ L I PQ
Sbjct: 258 TFFCFTNLMAEIRDNFIKSLD-DSQCGITYKMEKVYSTL-KDKDVELYLKLQEQNIKPQF 315
Query: 330 YGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCL 389
+ RW+ LL +EF L D++ +WD+LFAD + + AML+ IR+ L+ ++ +
Sbjct: 316 FAFRWLTLLLSQEFLLPDVIRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLEGDFTVNM 375
Query: 390 GLLMHYPFIGDVHSLILKALFLRDPK 415
LL YP I DV ++ KA L+D K
Sbjct: 376 RLLQDYP-ITDVCQILQKAKELQDSK 400
>gi|34147456 TBC domain-containing protein kinase-like [Homo
sapiens]
Length = 830
Score = 57.0 bits (136), Expect = 7e-08
Identities = 35/130 (26%), Positives = 61/130 (46%), Gaps = 5/130 (3%)
Query: 297 IVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALF 356
++ + + ++ HD EL HLN + P +Y + W +F FPL + +WD L
Sbjct: 526 VIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLL 585
Query: 357 ADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKR 416
S I VA+L +RD L+++ + C+ L P I D+ + +++ L
Sbjct: 586 LGNSSFPFC--IGVAILQQLRDRLLANGFNECILLFSDLPEI-DIERCVRESINLF--CW 640
Query: 417 NPRPVTYQFH 426
P+ TY+ H
Sbjct: 641 TPKSATYRQH 650
>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
Length = 505
Score = 56.6 bits (135), Expect = 9e-08
Identities = 58/239 (24%), Positives = 107/239 (44%), Gaps = 34/239 (14%)
Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDH- 221
I D+ RT P + FQQ V++I +LF +A + Y QG+++L+ P V ++
Sbjct: 268 IHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYV 327
Query: 222 QAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMT 281
+ + + S++M +E D++ S+L+ DG + T
Sbjct: 328 EEDVENFDVTNLSQDML-----RSIEADSFWCMSKLL------------DGIQDNYT--- 367
Query: 282 PIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGR 341
FA+P I KV +++ L+ + D +++ H R E+ + RW+ L R
Sbjct: 368 ---FAQP-------GIQKKVKALEE-LVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMR 416
Query: 342 EFPLQDLLVVWDALFADGLSLGLVD-YIFVAMLL-YIRDALISSNYQTCLGLLMHYPFI 398
E PL+ + +WD ++ Y+ A L+ + ++ L ++Q L LL + P I
Sbjct: 417 ELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTI 475
>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
Length = 517
Score = 53.5 bits (127), Expect = 8e-07
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 46/243 (18%)
Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
I D+ R PE Q + V +I +LF +A + Y QG+++L+ P V C+
Sbjct: 280 IHIDIPRMSPEALILQPK-VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICE-- 336
Query: 223 AFLHASE------SAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGK 276
++ A E S P+E + + E D Y S+L+ DG +
Sbjct: 337 -YIEAEEVDTVDVSGVPAEVLCNI------EADTYWCMSKLL------------DGIQDN 377
Query: 277 ETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVR 336
T FA+P I KV +++ L+ + D +++ HL++ E+ + RW+
Sbjct: 378 YT------FAQP-------GIQMKVKMLEE-LVSRIDEQVHRHLDQHEVRYLQFAFRWMN 423
Query: 337 LLFGREFPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLL-YIRDALISSNYQTCLGLLM 393
L RE PL+ + +WD + DG S + Y+ A L+ + ++ L ++Q L L
Sbjct: 424 NLLMREVPLRCTIRLWDTYQSEPDGFSHFHL-YVCAAFLVRWRKEILEEKDFQELLLFLQ 482
Query: 394 HYP 396
+ P
Sbjct: 483 NLP 485
>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
Length = 648
Score = 51.6 bits (122), Expect = 3e-06
Identities = 57/228 (25%), Positives = 93/228 (40%), Gaps = 55/228 (24%)
Query: 160 RSMIEQDVKRTFPEMQFFQ--QENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217
RS+IE+DV RT +F++ + +L D+L Y + L Y QGM +LL+PI++V+
Sbjct: 372 RSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVI 431
Query: 218 HCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKE 277
E DA+ F ME + F ++ +E
Sbjct: 432 Q---------------------------NEVDAFWCFCGFMELVQGNF-------EESQE 457
Query: 278 TLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRL 337
T+ + LG + LL+ D L L+ + + RW+ +
Sbjct: 458 TM--------KRQLGRLLL-----------LLRVLDPLLCDFLDSQDSGSLCFCFRWLLI 498
Query: 338 LFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNY 385
F REFP D+L +W+ L+ L + A+L RD L+ S +
Sbjct: 499 WFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGF 546
>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
Length = 682
Score = 46.2 bits (108), Expect = 1e-04
Identities = 27/70 (38%), Positives = 44/70 (62%), Gaps = 2/70 (2%)
Query: 157 KELRSMIEQDVKRTFPEMQFFQ-QENVRKILT-DVLFCYARENEQLLYKQGMHELLAPIV 214
++ RS+IE+DV RT +F++ Q+N IL D+L Y + L Y QGM +LL+P++
Sbjct: 396 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 455
Query: 215 FVLHCDHQAF 224
+V+ + AF
Sbjct: 456 YVMENEVDAF 465
>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
Length = 696
Score = 46.2 bits (108), Expect = 1e-04
Identities = 27/70 (38%), Positives = 44/70 (62%), Gaps = 2/70 (2%)
Query: 157 KELRSMIEQDVKRTFPEMQFFQ-QENVRKILT-DVLFCYARENEQLLYKQGMHELLAPIV 214
++ RS+IE+DV RT +F++ Q+N IL D+L Y + L Y QGM +LL+P++
Sbjct: 410 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 469
Query: 215 FVLHCDHQAF 224
+V+ + AF
Sbjct: 470 YVMENEVDAF 479
>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
Length = 713
Score = 46.2 bits (108), Expect = 1e-04
Identities = 27/70 (38%), Positives = 44/70 (62%), Gaps = 2/70 (2%)
Query: 157 KELRSMIEQDVKRTFPEMQFFQ-QENVRKILT-DVLFCYARENEQLLYKQGMHELLAPIV 214
++ RS+IE+DV RT +F++ Q+N IL D+L Y + L Y QGM +LL+P++
Sbjct: 427 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 486
Query: 215 FVLHCDHQAF 224
+V+ + AF
Sbjct: 487 YVMENEVDAF 496
>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
Length = 767
Score = 45.4 bits (106), Expect = 2e-04
Identities = 65/273 (23%), Positives = 111/273 (40%), Gaps = 65/273 (23%)
Query: 157 KELRSMIEQDVKRTFPEMQFFQQENVRKI--LTDVLFCYARENEQLLYKQGMHELLAPIV 214
+ ++ +++DV RT QFF+ E+ + + +L YA N + Y QGM +L+API
Sbjct: 482 RNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI- 540
Query: 215 FVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQK 274
+ VL+ E D + F LM+
Sbjct: 541 ----------------------LAEVLD----ESDTFWCFVGLMQN-------------- 560
Query: 275 GKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRL--EIAPQIYGL 332
T+ P R +D+ + + + LL+ + Y HL L + ++
Sbjct: 561 ---TIFVSSP--RDEDMEKQLLYLRE-------LLRLTHVRFYQHLVSLGEDGLQMLFCH 608
Query: 333 RWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLL 392
RW+ L F REFP + L +W+A +A + +I VA++ D +I T +L
Sbjct: 609 RWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATD-QML 667
Query: 393 MHYPFIGDVHSLILKALFLRDPKRNPRPVTYQF 425
+H+ G++ + L L R R + YQF
Sbjct: 668 LHF---GNLAMHMNGELVL----RKARSLLYQF 693
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 43.9 bits (102), Expect = 6e-04
Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 6/85 (7%)
Query: 308 LLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDY 367
LL++ + HL R I P +Y W +F R P +L VWD F +G+ +
Sbjct: 497 LLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKI----- 551
Query: 368 IFVAMLLYIRDALIS-SNYQTCLGL 391
IF L+ +R L S ++C G+
Sbjct: 552 IFRVALVLLRHTLGSVEKLRSCQGM 576
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 43.5 bits (101), Expect = 8e-04
Identities = 35/134 (26%), Positives = 58/134 (43%), Gaps = 20/134 (14%)
Query: 288 PQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQD 347
P GP + V ++ LL++ ++ HL ++ + P +Y W LF R P
Sbjct: 209 PGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPT 268
Query: 348 LLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQ-TCLGL--------------L 392
+L VWDA ++G + +F L +R AL ++ + C GL L
Sbjct: 269 VLRVWDAFLSEGARV-----LFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQL 323
Query: 393 MHYPFIGDVHSLIL 406
F+ VHS++L
Sbjct: 324 QEEAFMSQVHSVVL 337
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 43.1 bits (100), Expect = 0.001
Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 6/84 (7%)
Query: 308 LLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDY 367
LL+K + HL+R +I P +Y W F R P +L VWD F +G+ +
Sbjct: 248 LLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKI----- 302
Query: 368 IFVAMLLYIRDALIS-SNYQTCLG 390
IF L+ ++ AL S + C G
Sbjct: 303 IFRVGLVLLKHALGSPEKVKACQG 326
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 41.6 bits (96), Expect = 0.003
Identities = 21/64 (32%), Positives = 32/64 (50%), Gaps = 1/64 (1%)
Query: 297 IVTKVNQIQ-DHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDAL 355
I+ ++ Q LL + +LY HL EI P +Y W +F +FPL + V+D +
Sbjct: 931 IILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMI 990
Query: 356 FADG 359
F G
Sbjct: 991 FLQG 994
>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
sapiens]
Length = 1032
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 56/224 (25%)
Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
IE+DV+R +F N+ K L +++ Y ++ ++ Y QGM +LLAP++ +L D +
Sbjct: 823 IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 879
Query: 223 AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282
A A++ F++LM+ F H G
Sbjct: 880 AL-------------------------AFSCFTELMKRMN---QNFPHGGA--------- 902
Query: 283 IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGRE 342
+ A + + QI D L EL MH N + + RW L F RE
Sbjct: 903 --------MDTHFANMRSLIQILDSEL----FEL-MHQNG-DYTHFYFCYRWFLLDFKRE 948
Query: 343 FPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384
D+ +VW+ ++A S V +I +A++ RD ++ +N
Sbjct: 949 LVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 992
>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
sapiens]
Length = 1093
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 56/224 (25%)
Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
IE+DV+R +F N+ K L +++ Y ++ ++ Y QGM +LLAP++ +L D +
Sbjct: 884 IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 940
Query: 223 AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282
A A++ F++LM+ F H G
Sbjct: 941 AL-------------------------AFSCFTELMKRMN---QNFPHGGA--------- 963
Query: 283 IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGRE 342
+ A + + QI D L EL MH N + + RW L F RE
Sbjct: 964 --------MDTHFANMRSLIQILDSEL----FEL-MHQNG-DYTHFYFCYRWFLLDFKRE 1009
Query: 343 FPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384
D+ +VW+ ++A S V +I +A++ RD ++ +N
Sbjct: 1010 LVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1053
>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
Length = 1087
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 56/224 (25%)
Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
IE+DV+R +F N+ K L +++ Y ++ ++ Y QGM +LLAP++ +L D +
Sbjct: 878 IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 934
Query: 223 AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282
A A++ F++LM+ F H G
Sbjct: 935 AL-------------------------AFSCFTELMKRMN---QNFPHGGA--------- 957
Query: 283 IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGRE 342
+ A + + QI D L EL MH N + + RW L F RE
Sbjct: 958 --------MDTHFANMRSLIQILDSEL----FEL-MHQNG-DYTHFYFCYRWFLLDFKRE 1003
Query: 343 FPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384
D+ +VW+ ++A S V +I +A++ RD ++ +N
Sbjct: 1004 LVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1047
>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
Length = 1148
Score = 41.6 bits (96), Expect = 0.003
Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 56/224 (25%)
Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
IE+DV+R +F N+ K L +++ Y ++ ++ Y QGM +LLAP++ +L D +
Sbjct: 939 IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 995
Query: 223 AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282
A A++ F++LM+ F H G
Sbjct: 996 AL-------------------------AFSCFTELMKRMN---QNFPHGGA--------- 1018
Query: 283 IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGRE 342
+ A + + QI D L EL MH N + + RW L F RE
Sbjct: 1019 --------MDTHFANMRSLIQILDSEL----FEL-MHQNG-DYTHFYFCYRWFLLDFKRE 1064
Query: 343 FPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384
D+ +VW+ ++A S V +I +A++ RD ++ +N
Sbjct: 1065 LVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1108
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 40.8 bits (94), Expect = 0.005
Identities = 47/231 (20%), Positives = 89/231 (38%), Gaps = 56/231 (24%)
Query: 161 SMIEQDVKRTFPEMQFFQQE--NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLH 218
S I +D+ RTFP +F+ + + L + Y+ +E++ Y QG L A V +LH
Sbjct: 604 SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAA--VLLLH 661
Query: 219 CDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKET 278
P E+ +VL ++ +F Q E F E
Sbjct: 662 -------------MPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLER-------- 700
Query: 279 LMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLL 338
L++++ +LY H + + +Y +W L
Sbjct: 701 -----------------------------LMQEYIPDLYNHFLDISLEAHMYASQWFLTL 731
Query: 339 FGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCL 389
F +FPL + + D L +G+S ++ + + +L +D L+ ++++ L
Sbjct: 732 FTAKFPLYMVFHIIDLLLCEGIS--VIFNVALGLLKTSKDDLLLTDFEGAL 780
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 40.4 bits (93), Expect = 0.007
Identities = 39/200 (19%), Positives = 71/200 (35%), Gaps = 55/200 (27%)
Query: 162 MIEQDVKRTFPEMQFFQQEN-VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCD 220
+I+ D+ RTFP + FQ+ +L +L Y + Y QGM + A ++ L
Sbjct: 546 LIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLE-- 603
Query: 221 HQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLM-ETAEPWFSTFEHDGQKGKETL 279
E DA+ F+ L+ + + F +H
Sbjct: 604 --------------------------EADAFIAFANLLNKPCQLAFFRVDH--------- 628
Query: 280 MTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLF 339
+++ K + +++ +L++H + P IY + W+ L+
Sbjct: 629 ----------------SMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLY 672
Query: 340 GREFPLQDLLVVWDALFADG 359
+ PL VWD DG
Sbjct: 673 SKSLPLDLACRVWDVFCRDG 692
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 39.3 bits (90), Expect = 0.015
Identities = 49/241 (20%), Positives = 93/241 (38%), Gaps = 64/241 (26%)
Query: 155 QDKELRSMIEQDVKRTFPEMQFFQ------QENVRKILTDVLFCYARENEQLLYKQGMHE 208
+D S+I +D+ RTFP +F+ QE++ KI Y+ +E + Y QG
Sbjct: 570 KDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICK----AYSVYDEDIGYCQGQSF 625
Query: 209 LLAPIVFVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTF 268
L A V +LH P E+ VL ++ ++ E F
Sbjct: 626 LAA--VLLLH-------------MPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQL 670
Query: 269 EHDGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQ 328
E L+++ +L+ H + L +
Sbjct: 671 ER-------------------------------------LMQEQLPDLHSHFSDLNLEAH 693
Query: 329 IYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTC 388
+Y +W LF +FPL + + D L +GL+ ++ ++ +A+L ++ L+ ++++
Sbjct: 694 MYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLN--IIFHVALALLKTSKEDLLQADFEGA 751
Query: 389 L 389
L
Sbjct: 752 L 752
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 38.9 bits (89), Expect = 0.019
Identities = 19/52 (36%), Positives = 27/52 (51%)
Query: 308 LLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADG 359
LL + +LY HL EI+P +Y W LF +F L + V+D +F G
Sbjct: 1061 LLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQG 1112
>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
Length = 413
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/200 (21%), Positives = 68/200 (34%), Gaps = 55/200 (27%)
Query: 162 MIEQDVKRTFPEMQFFQQEN-VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCD 220
+I+ D+ RTFP + FQQ +L +L Y + Y QGM + A V +L+ D
Sbjct: 185 LIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAA--VLILNLD 242
Query: 221 HQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLM-ETAEPWFSTFEHDGQKGKETL 279
DA+ FS L+ + + F +H
Sbjct: 243 TA--------------------------DAFIAFSNLLNKPCQMAFFRVDH--------- 267
Query: 280 MTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLF 339
G + + L K L+ H + + P IY + W+ L+
Sbjct: 268 ------------GLMLTYFAAFEVFFEENLPK----LFAHFKKNNLTPDIYLIDWIFTLY 311
Query: 340 GREFPLQDLLVVWDALFADG 359
+ PL +WD DG
Sbjct: 312 SKSLPLDLACRIWDVFCRDG 331
>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/200 (21%), Positives = 68/200 (34%), Gaps = 55/200 (27%)
Query: 162 MIEQDVKRTFPEMQFFQQEN-VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCD 220
+I+ D+ RTFP + FQQ +L +L Y + Y QGM + A V +L+ D
Sbjct: 465 LIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAA--VLILNLD 522
Query: 221 HQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLM-ETAEPWFSTFEHDGQKGKETL 279
DA+ FS L+ + + F +H
Sbjct: 523 TA--------------------------DAFIAFSNLLNKPCQMAFFRVDH--------- 547
Query: 280 MTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLF 339
G + + L K L+ H + + P IY + W+ L+
Sbjct: 548 ------------GLMLTYFAAFEVFFEENLPK----LFAHFKKNNLTPDIYLIDWIFTLY 591
Query: 340 GREFPLQDLLVVWDALFADG 359
+ PL +WD DG
Sbjct: 592 SKSLPLDLACRIWDVFCRDG 611
>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/200 (21%), Positives = 68/200 (34%), Gaps = 55/200 (27%)
Query: 162 MIEQDVKRTFPEMQFFQQEN-VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCD 220
+I+ D+ RTFP + FQQ +L +L Y + Y QGM + A V +L+ D
Sbjct: 465 LIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAA--VLILNLD 522
Query: 221 HQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLM-ETAEPWFSTFEHDGQKGKETL 279
DA+ FS L+ + + F +H
Sbjct: 523 TA--------------------------DAFIAFSNLLNKPCQMAFFRVDH--------- 547
Query: 280 MTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLF 339
G + + L K L+ H + + P IY + W+ L+
Sbjct: 548 ------------GLMLTYFAAFEVFFEENLPK----LFAHFKKNNLTPDIYLIDWIFTLY 591
Query: 340 GREFPLQDLLVVWDALFADG 359
+ PL +WD DG
Sbjct: 592 SKSLPLDLACRIWDVFCRDG 611
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 37.4 bits (85), Expect = 0.057
Identities = 53/218 (24%), Positives = 87/218 (39%), Gaps = 41/218 (18%)
Query: 27 YSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWEELFVNNNYLATIRQ-----------K 75
YS S S+ R TSS D E FN +N N + T Q +
Sbjct: 424 YSRPSSLVSSSPQRSTSSDADGERQFN----------LNGNSVPTATQTLMTMYRRRSPE 473
Query: 76 GINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNPRKVVGQQD 135
N +L + WK+ Q + R E+ R +K I P + G+
Sbjct: 474 EFNPKLAKEFLKEQAWKIHFAEYGQGICMY--RTEKTRELV--LKGI----PESMRGELW 525
Query: 136 LMINNPLSQDEGSLWNKFFQDKELRSM---------IEQDVKRTFPEMQFFQQENVRKIL 186
L+++ ++ E + +++D +SM IE+D+ R+ PE FQ E L
Sbjct: 526 LLLSGAIN--EKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAAL 583
Query: 187 TDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAF 224
VL YA N + Y Q M+ ++ ++ + + +AF
Sbjct: 584 RRVLTAYAFRNPNIGYCQAMN-IVTSVLLLYAKEEEAF 620
>gi|148612829 RUN and TBC1 domain containing 1 isoform 2 [Homo
sapiens]
Length = 1006
Score = 37.4 bits (85), Expect = 0.057
Identities = 22/62 (35%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
I++DV+R +F N+ + L DV+ Y E+ + Y QGM +LLAP++ L D
Sbjct: 797 IDKDVQRCDRNYWYFTPPNLER-LRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 855
Query: 223 AF 224
A+
Sbjct: 856 AY 857
>gi|148612795 RUN and TBC1 domain containing 1 isoform 1 [Homo
sapiens]
Length = 1051
Score = 37.4 bits (85), Expect = 0.057
Identities = 22/62 (35%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
I++DV+R +F N+ + L DV+ Y E+ + Y QGM +LLAP++ L D
Sbjct: 842 IDKDVQRCDRNYWYFTPPNLER-LRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQL 900
Query: 223 AF 224
A+
Sbjct: 901 AY 902
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,173,933
Number of Sequences: 37866
Number of extensions: 1548004
Number of successful extensions: 8423
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 8032
Number of HSP's gapped (non-prelim): 449
length of query: 817
length of database: 18,247,518
effective HSP length: 111
effective length of query: 706
effective length of database: 14,044,392
effective search space: 9915340752
effective search space used: 9915340752
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.