Search of human proteins with 197304775

Search of human proteins with 197304775

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|197304775 TBC1 domain family, member 5 isoform b [Homo
sapiens]
         (795 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens]   1591   0.0  
gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens]     1591   0.0  
gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]   1578   0.0  
gi|190014603 TBC1 domain family, member 13 [Homo sapiens]             113   8e-25
gi|34147456 TBC domain-containing protein kinase-like [Homo sapi...    57   7e-08
gi|40068063 TBC1 domain family, member 22B [Homo sapiens]              57   9e-08
gi|22507409 TBC1 domain family, member 22A [Homo sapiens]              54   7e-07
gi|13375952 TBC1 domain family, member 17 [Homo sapiens]               52   3e-06
gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]    46   1e-04
gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]    46   1e-04
gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]    46   1e-04
gi|33563376 TBC1 domain family, member 16 [Homo sapiens]               45   2e-04
gi|167614488 TBC1 domain family, member 10B [Homo sapiens]             44   6e-04
gi|38348348 TBC1 domain family, member 10C [Homo sapiens]              44   8e-04
gi|13994322 TBC1 domain family, member 10A [Homo sapiens]              43   0.001
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member...    42   0.003
gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo sa...    42   0.003
gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo sa...    42   0.003
gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sap...    42   0.003
gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sap...    42   0.003
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]            41   0.005
gi|148806902 TBC1 domain family, member 12 [Homo sapiens]              40   0.007
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo...    39   0.014
gi|114688046 TBC1 domain family, member 4 [Homo sapiens]               39   0.019
gi|130502140 NEZHA isoform 2 [Homo sapiens]                            38   0.032
gi|122937255 NEZHA isoform 1 [Homo sapiens]                            38   0.032
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]    38   0.042
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]    38   0.042
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]    38   0.042
gi|33457336 chromosome 14 open reading frame 4 [Homo sapiens]          38   0.042

>gi|197304775 TBC1 domain family, member 5 isoform b [Homo sapiens]
          Length = 795

 Score = 1591 bits (4119), Expect = 0.0
 Identities = 795/795 (100%), Positives = 795/795 (100%)

Query: 1   MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60
           MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
Sbjct: 1   MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60

Query: 61  ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120
           ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
Sbjct: 61  ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120

Query: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180
           EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
Sbjct: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180

Query: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240
           NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
Sbjct: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240

Query: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300
           LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
Sbjct: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300

Query: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360
           VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
Sbjct: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360

Query: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420
           SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
Sbjct: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420

Query: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480
           VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
Sbjct: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480

Query: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP 540
           PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
Sbjct: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP 540

Query: 541 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN 600
           SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
Sbjct: 541 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN 600

Query: 601 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL 660
           DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
Sbjct: 601 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL 660

Query: 661 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK 720
           EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
Sbjct: 661 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK 720

Query: 721 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD 780
           DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
Sbjct: 721 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD 780

Query: 781 SSKDSGFTIVSPLDI 795
           SSKDSGFTIVSPLDI
Sbjct: 781 SSKDSGFTIVSPLDI 795


>gi|7661998 TBC1 domain family, member 5 isoform b [Homo sapiens]
          Length = 795

 Score = 1591 bits (4119), Expect = 0.0
 Identities = 795/795 (100%), Positives = 795/795 (100%)

Query: 1   MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60
           MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
Sbjct: 1   MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60

Query: 61  ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120
           ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
Sbjct: 61  ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120

Query: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180
           EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
Sbjct: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180

Query: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240
           NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
Sbjct: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240

Query: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300
           LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
Sbjct: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300

Query: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360
           VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
Sbjct: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360

Query: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420
           SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
Sbjct: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420

Query: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480
           VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
Sbjct: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480

Query: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP 540
           PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
Sbjct: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP 540

Query: 541 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN 600
           SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
Sbjct: 541 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN 600

Query: 601 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL 660
           DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
Sbjct: 601 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL 660

Query: 661 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK 720
           EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
Sbjct: 661 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK 720

Query: 721 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD 780
           DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
Sbjct: 721 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD 780

Query: 781 SSKDSGFTIVSPLDI 795
           SSKDSGFTIVSPLDI
Sbjct: 781 SSKDSGFTIVSPLDI 795


>gi|197304777 TBC1 domain family, member 5 isoform a [Homo sapiens]
          Length = 817

 Score = 1578 bits (4086), Expect = 0.0
 Identities = 795/817 (97%), Positives = 795/817 (97%), Gaps = 22/817 (2%)

Query: 1   MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60
           MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
Sbjct: 1   MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE 60

Query: 61  ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120
           ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
Sbjct: 61  ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK 120

Query: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180
           EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
Sbjct: 121 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE 180

Query: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240
           NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
Sbjct: 181 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV 240

Query: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300
           LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
Sbjct: 241 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK 300

Query: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360
           VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
Sbjct: 301 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL 360

Query: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420
           SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
Sbjct: 361 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP 420

Query: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480
           VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
Sbjct: 421 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG 480

Query: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNK----------- 529
           PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNK           
Sbjct: 481 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQV 540

Query: 530 -----------GLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT 578
                      GLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT
Sbjct: 541 SVPVQTLTDLQGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKT 600

Query: 579 MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS 638
           MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS
Sbjct: 601 MGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVS 660

Query: 639 LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ 698
           LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ
Sbjct: 661 LAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQ 720

Query: 699 ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF 758
           ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF
Sbjct: 721 ASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVF 780

Query: 759 SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI 795
           SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI
Sbjct: 781 SDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI 817


>gi|190014603 TBC1 domain family, member 13 [Homo sapiens]
          Length = 400

 Score =  113 bits (282), Expect = 8e-25
 Identities = 101/386 (26%), Positives = 168/386 (43%), Gaps = 47/386 (12%)

Query: 69  LATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNP- 127
           L  +R+   +G       R +CWK+ L  LP +++ W S + + R  Y+      I  P 
Sbjct: 23  LEKLRELSFSGIPCEGGLRCLCWKILLNYLPLERASWTSILAKQRELYAQFLREMIIQPG 82

Query: 128 ----RKVVGQQDLMI-NNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQ--- 179
                  V ++D+   ++PL+ +  S WN +F+D E+   I++DV+R  P++ FFQ+   
Sbjct: 83  IAKANMGVSREDVTFEDHPLNPNPDSRWNTYFKDNEVLLQIDKDVRRLCPDISFFQRATD 142

Query: 180 -------------ENVRKILTDVLF---CYARENEQLLYKQGMHELLAPIVFVLHCDHQA 223
                        E +RK +          AR    +      H+   P       +++ 
Sbjct: 143 YPCLLILDPQNEFETLRKRVEQTTLKSQTVARNRSGVTNMSSPHKNSVPSSL---NEYEV 199

Query: 224 FLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHD-GQKGKE----- 277
             +  E+    E ++ +L      +   A    + E   P + TF  D   + KE     
Sbjct: 200 LPNGCEAHW--EVVERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEAD 257

Query: 278 ------TLMTPI--PFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQI 329
                  LM  I   F +  D      I  K+ ++   L K  D+ELY+ L    I PQ 
Sbjct: 258 TFFCFTNLMAEIRDNFIKSLD-DSQCGITYKMEKVYSTL-KDKDVELYLKLQEQNIKPQF 315

Query: 330 YGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCL 389
           +  RW+ LL  +EF L D++ +WD+LFAD      +  +  AML+ IR+ L+  ++   +
Sbjct: 316 FAFRWLTLLLSQEFLLPDVIRIWDSLFADDNRFDFLLLVCCAMLMLIREQLLEGDFTVNM 375

Query: 390 GLLMHYPFIGDVHSLILKALFLRDPK 415
            LL  YP I DV  ++ KA  L+D K
Sbjct: 376 RLLQDYP-ITDVCQILQKAKELQDSK 400


>gi|34147456 TBC domain-containing protein kinase-like [Homo
           sapiens]
          Length = 830

 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 35/130 (26%), Positives = 61/130 (46%), Gaps = 5/130 (3%)

Query: 297 IVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALF 356
           ++ +   +   ++  HD EL  HLN +   P +Y + W   +F   FPL  +  +WD L 
Sbjct: 526 VIQEYLTVFSQMIAFHDPELSNHLNEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLWDTLL 585

Query: 357 ADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKR 416
               S      I VA+L  +RD L+++ +  C+ L    P I D+   + +++ L     
Sbjct: 586 LGNSSFPFC--IGVAILQQLRDRLLANGFNECILLFSDLPEI-DIERCVRESINLF--CW 640

Query: 417 NPRPVTYQFH 426
            P+  TY+ H
Sbjct: 641 TPKSATYRQH 650


>gi|40068063 TBC1 domain family, member 22B [Homo sapiens]
          Length = 505

 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 58/239 (24%), Positives = 107/239 (44%), Gaps = 34/239 (14%)

Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDH- 221
           I  D+ RT P +  FQQ  V++I   +LF +A  +    Y QG+++L+ P   V   ++ 
Sbjct: 268 IHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYV 327

Query: 222 QAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMT 281
           +  +   +    S++M        +E D++   S+L+            DG +   T   
Sbjct: 328 EEDVENFDVTNLSQDML-----RSIEADSFWCMSKLL------------DGIQDNYT--- 367

Query: 282 PIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGR 341
              FA+P        I  KV  +++ L+ + D +++ H  R E+    +  RW+  L  R
Sbjct: 368 ---FAQP-------GIQKKVKALEE-LVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMR 416

Query: 342 EFPLQDLLVVWDALFADGLSLGLVD-YIFVAMLL-YIRDALISSNYQTCLGLLMHYPFI 398
           E PL+  + +WD   ++         Y+  A L+ + ++ L   ++Q  L LL + P I
Sbjct: 417 ELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTI 475


>gi|22507409 TBC1 domain family, member 22A [Homo sapiens]
          Length = 517

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 46/243 (18%)

Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
           I  D+ R  PE    Q + V +I   +LF +A  +    Y QG+++L+ P   V  C+  
Sbjct: 280 IHIDIPRMSPEALILQPK-VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICE-- 336

Query: 223 AFLHASE------SAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGK 276
            ++ A E      S  P+E +  +      E D Y   S+L+            DG +  
Sbjct: 337 -YIEAEEVDTVDVSGVPAEVLCNI------EADTYWCMSKLL------------DGIQDN 377

Query: 277 ETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVR 336
            T      FA+P        I  KV  +++ L+ + D +++ HL++ E+    +  RW+ 
Sbjct: 378 YT------FAQP-------GIQMKVKMLEE-LVSRIDEQVHRHLDQHEVRYLQFAFRWMN 423

Query: 337 LLFGREFPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLL-YIRDALISSNYQTCLGLLM 393
            L  RE PL+  + +WD   +  DG S   + Y+  A L+ + ++ L   ++Q  L  L 
Sbjct: 424 NLLMREVPLRCTIRLWDTYQSEPDGFSHFHL-YVCAAFLVRWRKEILEEKDFQELLLFLQ 482

Query: 394 HYP 396
           + P
Sbjct: 483 NLP 485


>gi|13375952 TBC1 domain family, member 17 [Homo sapiens]
          Length = 648

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 57/228 (25%), Positives = 93/228 (40%), Gaps = 55/228 (24%)

Query: 160 RSMIEQDVKRTFPEMQFFQ--QENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVL 217
           RS+IE+DV RT    +F++  +     +L D+L  Y   +  L Y QGM +LL+PI++V+
Sbjct: 372 RSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVI 431

Query: 218 HCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKE 277
                                        E DA+  F   ME  +  F       ++ +E
Sbjct: 432 Q---------------------------NEVDAFWCFCGFMELVQGNF-------EESQE 457

Query: 278 TLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRL 337
           T+         + LG  +            LL+  D  L   L+  +     +  RW+ +
Sbjct: 458 TM--------KRQLGRLLL-----------LLRVLDPLLCDFLDSQDSGSLCFCFRWLLI 498

Query: 338 LFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNY 385
            F REFP  D+L +W+ L+       L   +  A+L   RD L+ S +
Sbjct: 499 WFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGF 546


>gi|226342869 TBC1 domain family, member 15 isoform 2 [Homo sapiens]
          Length = 682

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 27/70 (38%), Positives = 44/70 (62%), Gaps = 2/70 (2%)

Query: 157 KELRSMIEQDVKRTFPEMQFFQ-QENVRKILT-DVLFCYARENEQLLYKQGMHELLAPIV 214
           ++ RS+IE+DV RT    +F++ Q+N   IL  D+L  Y   +  L Y QGM +LL+P++
Sbjct: 396 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 455

Query: 215 FVLHCDHQAF 224
           +V+  +  AF
Sbjct: 456 YVMENEVDAF 465


>gi|226342867 TBC1 domain family, member 15 isoform 3 [Homo sapiens]
          Length = 696

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 27/70 (38%), Positives = 44/70 (62%), Gaps = 2/70 (2%)

Query: 157 KELRSMIEQDVKRTFPEMQFFQ-QENVRKILT-DVLFCYARENEQLLYKQGMHELLAPIV 214
           ++ RS+IE+DV RT    +F++ Q+N   IL  D+L  Y   +  L Y QGM +LL+P++
Sbjct: 410 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 469

Query: 215 FVLHCDHQAF 224
           +V+  +  AF
Sbjct: 470 YVMENEVDAF 479


>gi|226342865 TBC1 domain family, member 15 isoform 1 [Homo sapiens]
          Length = 713

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 27/70 (38%), Positives = 44/70 (62%), Gaps = 2/70 (2%)

Query: 157 KELRSMIEQDVKRTFPEMQFFQ-QENVRKILT-DVLFCYARENEQLLYKQGMHELLAPIV 214
           ++ RS+IE+DV RT    +F++ Q+N   IL  D+L  Y   +  L Y QGM +LL+P++
Sbjct: 427 RDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLL 486

Query: 215 FVLHCDHQAF 224
           +V+  +  AF
Sbjct: 487 YVMENEVDAF 496


>gi|33563376 TBC1 domain family, member 16 [Homo sapiens]
          Length = 767

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 65/273 (23%), Positives = 111/273 (40%), Gaps = 65/273 (23%)

Query: 157 KELRSMIEQDVKRTFPEMQFFQQENVRKI--LTDVLFCYARENEQLLYKQGMHELLAPIV 214
           + ++  +++DV RT    QFF+ E+   +  +  +L  YA  N  + Y QGM +L+API 
Sbjct: 482 RNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPI- 540

Query: 215 FVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQK 274
                                 +  VL+    E D +  F  LM+               
Sbjct: 541 ----------------------LAEVLD----ESDTFWCFVGLMQN-------------- 560

Query: 275 GKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRL--EIAPQIYGL 332
              T+    P  R +D+   +  + +       LL+   +  Y HL  L  +    ++  
Sbjct: 561 ---TIFVSSP--RDEDMEKQLLYLRE-------LLRLTHVRFYQHLVSLGEDGLQMLFCH 608

Query: 333 RWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLL 392
           RW+ L F REFP  + L +W+A +A   +     +I VA++    D +I     T   +L
Sbjct: 609 RWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATD-QML 667

Query: 393 MHYPFIGDVHSLILKALFLRDPKRNPRPVTYQF 425
           +H+   G++   +   L L    R  R + YQF
Sbjct: 668 LHF---GNLAMHMNGELVL----RKARSLLYQF 693


>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
          Length = 808

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 6/85 (7%)

Query: 308 LLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDY 367
           LL++     + HL R  I P +Y   W   +F R  P   +L VWD  F +G+ +     
Sbjct: 497 LLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKI----- 551

Query: 368 IFVAMLLYIRDALIS-SNYQTCLGL 391
           IF   L+ +R  L S    ++C G+
Sbjct: 552 IFRVALVLLRHTLGSVEKLRSCQGM 576


>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
          Length = 446

 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 35/134 (26%), Positives = 58/134 (43%), Gaps = 20/134 (14%)

Query: 288 PQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQD 347
           P   GP +  V    ++   LL++    ++ HL ++ + P +Y   W   LF R  P   
Sbjct: 209 PGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPT 268

Query: 348 LLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQ-TCLGL--------------L 392
           +L VWDA  ++G  +     +F   L  +R AL ++  +  C GL              L
Sbjct: 269 VLRVWDAFLSEGARV-----LFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQL 323

Query: 393 MHYPFIGDVHSLIL 406
               F+  VHS++L
Sbjct: 324 QEEAFMSQVHSVVL 337


>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
          Length = 508

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 27/84 (32%), Positives = 40/84 (47%), Gaps = 6/84 (7%)

Query: 308 LLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDY 367
           LL+K     + HL+R +I P +Y   W    F R  P   +L VWD  F +G+ +     
Sbjct: 248 LLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKI----- 302

Query: 368 IFVAMLLYIRDALIS-SNYQTCLG 390
           IF   L+ ++ AL S    + C G
Sbjct: 303 IFRVGLVLLKHALGSPEKVKACQG 326


>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
           [Homo sapiens]
          Length = 1168

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 21/64 (32%), Positives = 32/64 (50%), Gaps = 1/64 (1%)

Query: 297 IVTKVNQIQ-DHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDAL 355
           I+ ++   Q   LL  +  +LY HL   EI P +Y   W   +F  +FPL  +  V+D +
Sbjct: 931 IILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMI 990

Query: 356 FADG 359
           F  G
Sbjct: 991 FLQG 994


>gi|148612875 RUN and TBC1 domain containing 2 isoform 4 [Homo
           sapiens]
          Length = 1032

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 56/224 (25%)

Query: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
           IE+DV+R      +F   N+ K L +++  Y  ++ ++ Y QGM +LLAP++ +L  D +
Sbjct: 823 IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 879

Query: 223 AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282
           A                          A++ F++LM+        F H G          
Sbjct: 880 AL-------------------------AFSCFTELMKRMN---QNFPHGGA--------- 902

Query: 283 IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGRE 342
                   +    A +  + QI D  L     EL MH N  +     +  RW  L F RE
Sbjct: 903 --------MDTHFANMRSLIQILDSEL----FEL-MHQNG-DYTHFYFCYRWFLLDFKRE 948

Query: 343 FPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384
               D+ +VW+ ++A     S   V +I +A++   RD ++ +N
Sbjct: 949 LVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 992


>gi|148612840 RUN and TBC1 domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1093

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 56/224 (25%)

Query: 163  IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
            IE+DV+R      +F   N+ K L +++  Y  ++ ++ Y QGM +LLAP++ +L  D +
Sbjct: 884  IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 940

Query: 223  AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282
            A                          A++ F++LM+        F H G          
Sbjct: 941  AL-------------------------AFSCFTELMKRMN---QNFPHGGA--------- 963

Query: 283  IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGRE 342
                    +    A +  + QI D  L     EL MH N  +     +  RW  L F RE
Sbjct: 964  --------MDTHFANMRSLIQILDSEL----FEL-MHQNG-DYTHFYFCYRWFLLDFKRE 1009

Query: 343  FPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384
                D+ +VW+ ++A     S   V +I +A++   RD ++ +N
Sbjct: 1010 LVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1053


>gi|90577164 RUN and TBC1 domain containing 2 isoform 2 [Homo sapiens]
          Length = 1087

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 56/224 (25%)

Query: 163  IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
            IE+DV+R      +F   N+ K L +++  Y  ++ ++ Y QGM +LLAP++ +L  D +
Sbjct: 878  IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 934

Query: 223  AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282
            A                          A++ F++LM+        F H G          
Sbjct: 935  AL-------------------------AFSCFTELMKRMN---QNFPHGGA--------- 957

Query: 283  IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGRE 342
                    +    A +  + QI D  L     EL MH N  +     +  RW  L F RE
Sbjct: 958  --------MDTHFANMRSLIQILDSEL----FEL-MHQNG-DYTHFYFCYRWFLLDFKRE 1003

Query: 343  FPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384
                D+ +VW+ ++A     S   V +I +A++   RD ++ +N
Sbjct: 1004 LVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1047


>gi|90577167 RUN and TBC1 domain containing 2 isoform 1 [Homo sapiens]
          Length = 1148

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 55/224 (24%), Positives = 93/224 (41%), Gaps = 56/224 (25%)

Query: 163  IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
            IE+DV+R      +F   N+ K L +++  Y  ++ ++ Y QGM +LLAP++ +L  D +
Sbjct: 939  IEKDVQRCDRNYWYFTPANLEK-LRNIMCSYIWQHIEIGYVQGMCDLLAPLLVIL--DDE 995

Query: 223  AFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTP 282
            A                          A++ F++LM+        F H G          
Sbjct: 996  AL-------------------------AFSCFTELMKRMN---QNFPHGGA--------- 1018

Query: 283  IPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGRE 342
                    +    A +  + QI D  L     EL MH N  +     +  RW  L F RE
Sbjct: 1019 --------MDTHFANMRSLIQILDSEL----FEL-MHQNG-DYTHFYFCYRWFLLDFKRE 1064

Query: 343  FPLQDLLVVWDALFA--DGLSLGLVDYIFVAMLLYIRDALISSN 384
                D+ +VW+ ++A     S   V +I +A++   RD ++ +N
Sbjct: 1065 LVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENN 1108


>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
          Length = 1069

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 47/231 (20%), Positives = 89/231 (38%), Gaps = 56/231 (24%)

Query: 161 SMIEQDVKRTFPEMQFFQQE--NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLH 218
           S I +D+ RTFP   +F+    + +  L  +   Y+  +E++ Y QG   L A  V +LH
Sbjct: 604 SAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAA--VLLLH 661

Query: 219 CDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKET 278
                         P E+  +VL     ++    +F Q  E     F   E         
Sbjct: 662 -------------MPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLER-------- 700

Query: 279 LMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLL 338
                                        L++++  +LY H   + +   +Y  +W   L
Sbjct: 701 -----------------------------LMQEYIPDLYNHFLDISLEAHMYASQWFLTL 731

Query: 339 FGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCL 389
           F  +FPL  +  + D L  +G+S  ++  + + +L   +D L+ ++++  L
Sbjct: 732 FTAKFPLYMVFHIIDLLLCEGIS--VIFNVALGLLKTSKDDLLLTDFEGAL 780


>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
          Length = 775

 Score = 40.4 bits (93), Expect = 0.007
 Identities = 39/200 (19%), Positives = 71/200 (35%), Gaps = 55/200 (27%)

Query: 162 MIEQDVKRTFPEMQFFQQEN-VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCD 220
           +I+ D+ RTFP +  FQ+      +L  +L  Y      + Y QGM  + A ++  L   
Sbjct: 546 LIKLDISRTFPSLYIFQKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLE-- 603

Query: 221 HQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLM-ETAEPWFSTFEHDGQKGKETL 279
                                     E DA+  F+ L+ +  +  F   +H         
Sbjct: 604 --------------------------EADAFIAFANLLNKPCQLAFFRVDH--------- 628

Query: 280 MTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLF 339
                           +++ K     +   +++  +L++H     + P IY + W+  L+
Sbjct: 629 ----------------SMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLY 672

Query: 340 GREFPLQDLLVVWDALFADG 359
            +  PL     VWD    DG
Sbjct: 673 SKSLPLDLACRVWDVFCRDG 692


>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
           sapiens]
          Length = 815

 Score = 39.3 bits (90), Expect = 0.014
 Identities = 49/241 (20%), Positives = 93/241 (38%), Gaps = 64/241 (26%)

Query: 155 QDKELRSMIEQDVKRTFPEMQFFQ------QENVRKILTDVLFCYARENEQLLYKQGMHE 208
           +D    S+I +D+ RTFP   +F+      QE++ KI       Y+  +E + Y QG   
Sbjct: 570 KDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICK----AYSVYDEDIGYCQGQSF 625

Query: 209 LLAPIVFVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTF 268
           L A  V +LH              P E+   VL     ++    ++    E     F   
Sbjct: 626 LAA--VLLLH-------------MPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQL 670

Query: 269 EHDGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQ 328
           E                                      L+++   +L+ H + L +   
Sbjct: 671 ER-------------------------------------LMQEQLPDLHSHFSDLNLEAH 693

Query: 329 IYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTC 388
           +Y  +W   LF  +FPL  +  + D L  +GL+  ++ ++ +A+L   ++ L+ ++++  
Sbjct: 694 MYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLN--IIFHVALALLKTSKEDLLQADFEGA 751

Query: 389 L 389
           L
Sbjct: 752 L 752


>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
          Length = 1298

 Score = 38.9 bits (89), Expect = 0.019
 Identities = 19/52 (36%), Positives = 27/52 (51%)

Query: 308  LLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADG 359
            LL  +  +LY HL   EI+P +Y   W   LF  +F L  +  V+D +F  G
Sbjct: 1061 LLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQG 1112


>gi|130502140 NEZHA isoform 2 [Homo sapiens]
          Length = 1249

 Score = 38.1 bits (87), Expect = 0.032
 Identities = 35/146 (23%), Positives = 62/146 (42%), Gaps = 7/146 (4%)

Query: 413 DPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPA 472
           +P   P+ VT  F P+L      G    N++ +    A  ++ +    L +  ++L++P 
Sbjct: 674 EPTSRPKAVT--FSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPP 731

Query: 473 MAPGSAGGP----VPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLN 528
            APGSA  P    +PG  +   ++   P R              Q  R  K  + P +L 
Sbjct: 732 EAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPK-HTRPAELR 790

Query: 529 KGLSSKNISSSPSVESLPGGREFTGS 554
               ++ ++    V+SLP  R+F+ S
Sbjct: 791 LAPLTRVLTPPHDVDSLPHLRKFSPS 816


>gi|122937255 NEZHA isoform 1 [Homo sapiens]
          Length = 1276

 Score = 38.1 bits (87), Expect = 0.032
 Identities = 35/146 (23%), Positives = 62/146 (42%), Gaps = 7/146 (4%)

Query: 413 DPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPA 472
           +P   P+ VT  F P+L      G    N++ +    A  ++ +    L +  ++L++P 
Sbjct: 701 EPTSRPKAVT--FSPDLGPVPHEGLGEYNRAVSKLSAALSSLQRDMQRLTDQQQRLLAPP 758

Query: 473 MAPGSAGGP----VPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLN 528
            APGSA  P    +PG  +   ++   P R              Q  R  K  + P +L 
Sbjct: 759 EAPGSAPPPAAWVIPGPTTGPKAASPSPARRVPATRRSPGPGPSQSPRSPK-HTRPAELR 817

Query: 529 KGLSSKNISSSPSVESLPGGREFTGS 554
               ++ ++    V+SLP  R+F+ S
Sbjct: 818 LAPLTRVLTPPHDVDSLPHLRKFSPS 843


>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
          Length = 413

 Score = 37.7 bits (86), Expect = 0.042
 Identities = 43/200 (21%), Positives = 68/200 (34%), Gaps = 55/200 (27%)

Query: 162 MIEQDVKRTFPEMQFFQQEN-VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCD 220
           +I+ D+ RTFP +  FQQ      +L  +L  Y      + Y QGM  + A  V +L+ D
Sbjct: 185 LIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAA--VLILNLD 242

Query: 221 HQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLM-ETAEPWFSTFEHDGQKGKETL 279
                                       DA+  FS L+ +  +  F   +H         
Sbjct: 243 TA--------------------------DAFIAFSNLLNKPCQMAFFRVDH--------- 267

Query: 280 MTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLF 339
                       G  +          +  L K    L+ H  +  + P IY + W+  L+
Sbjct: 268 ------------GLMLTYFAAFEVFFEENLPK----LFAHFKKNNLTPDIYLIDWIFTLY 311

Query: 340 GREFPLQDLLVVWDALFADG 359
            +  PL     +WD    DG
Sbjct: 312 SKSLPLDLACRIWDVFCRDG 331


>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 37.7 bits (86), Expect = 0.042
 Identities = 43/200 (21%), Positives = 68/200 (34%), Gaps = 55/200 (27%)

Query: 162 MIEQDVKRTFPEMQFFQQEN-VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCD 220
           +I+ D+ RTFP +  FQQ      +L  +L  Y      + Y QGM  + A  V +L+ D
Sbjct: 465 LIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAA--VLILNLD 522

Query: 221 HQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLM-ETAEPWFSTFEHDGQKGKETL 279
                                       DA+  FS L+ +  +  F   +H         
Sbjct: 523 TA--------------------------DAFIAFSNLLNKPCQMAFFRVDH--------- 547

Query: 280 MTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLF 339
                       G  +          +  L K    L+ H  +  + P IY + W+  L+
Sbjct: 548 ------------GLMLTYFAAFEVFFEENLPK----LFAHFKKNNLTPDIYLIDWIFTLY 591

Query: 340 GREFPLQDLLVVWDALFADG 359
            +  PL     +WD    DG
Sbjct: 592 SKSLPLDLACRIWDVFCRDG 611


>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score = 37.7 bits (86), Expect = 0.042
 Identities = 43/200 (21%), Positives = 68/200 (34%), Gaps = 55/200 (27%)

Query: 162 MIEQDVKRTFPEMQFFQQEN-VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCD 220
           +I+ D+ RTFP +  FQQ      +L  +L  Y      + Y QGM  + A  V +L+ D
Sbjct: 465 LIKLDISRTFPNLCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAA--VLILNLD 522

Query: 221 HQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLM-ETAEPWFSTFEHDGQKGKETL 279
                                       DA+  FS L+ +  +  F   +H         
Sbjct: 523 TA--------------------------DAFIAFSNLLNKPCQMAFFRVDH--------- 547

Query: 280 MTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLF 339
                       G  +          +  L K    L+ H  +  + P IY + W+  L+
Sbjct: 548 ------------GLMLTYFAAFEVFFEENLPK----LFAHFKKNNLTPDIYLIDWIFTLY 591

Query: 340 GREFPLQDLLVVWDALFADG 359
            +  PL     +WD    DG
Sbjct: 592 SKSLPLDLACRIWDVFCRDG 611


>gi|33457336 chromosome 14 open reading frame 4 [Homo sapiens]
          Length = 796

 Score = 37.7 bits (86), Expect = 0.042
 Identities = 29/102 (28%), Positives = 46/102 (45%), Gaps = 5/102 (4%)

Query: 477 SAGGPVPGGN-----SSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGL 531
           S G P P G      S+  ++       +A A +   QQQQQQQ+  + +    Q  + L
Sbjct: 69  SPGPPPPVGVKTVALSAKEAAAAAAAAAAAAAAAQQQQQQQQQQQQQQQQQQQQQQQQQL 128

Query: 532 SSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSR 573
           +  + SS P+V + P G E  G   ++A    +  +   RSR
Sbjct: 129 NHVDGSSKPAVLAAPSGLERYGLSAAAAAAAAAAAAVEQRSR 170


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,492,325
Number of Sequences: 37866
Number of extensions: 1518026
Number of successful extensions: 8535
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 109
Number of HSP's that attempted gapping in prelim test: 8063
Number of HSP's gapped (non-prelim): 526
length of query: 795
length of database: 18,247,518
effective HSP length: 110
effective length of query: 685
effective length of database: 14,082,258
effective search space: 9646346730
effective search space used: 9646346730
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.