Search of human proteins with 197304715

Search of human proteins with 197304715

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
         (878 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...  1805   0.0  
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...  1696   0.0  
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...   917   0.0  
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]    854   0.0  
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ...   268   2e-71
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]          110   6e-24
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          110   6e-24
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   109   1e-23
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...   106   1e-22
gi|23308553 spermatogenesis associated 13 [Homo sapiens]              104   3e-22
gi|71274148 pleckstrin homology domain containing, family G (wit...   100   5e-21
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]              99   1e-20
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    99   2e-20
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...    99   2e-20
gi|5729856 GRB2-related adaptor protein [Homo sapiens]                 92   2e-18
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...    85   3e-16
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    83   1e-15
gi|55749621 pleckstrin homology domain containing, family G, mem...    83   1e-15
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...    80   8e-15
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...    80   8e-15
gi|166197690 neuronal guanine nucleotide exchange factor isoform...    80   1e-14
gi|166197688 neuronal guanine nucleotide exchange factor isoform...    80   1e-14
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    80   1e-14
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    80   1e-14
gi|153791628 MCF.2 cell line derived transforming sequence isofo...    78   4e-14
gi|153791325 MCF.2 cell line derived transforming sequence isofo...    78   4e-14
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                77   9e-14
gi|163644325 MCF.2 cell line derived transforming sequence-like ...    76   2e-13
gi|163644323 MCF.2 cell line derived transforming sequence-like ...    76   2e-13
gi|39930351 dynamin binding protein [Homo sapiens]                     75   3e-13

>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 1805 bits (4674), Expect = 0.0
 Identities = 878/878 (100%), Positives = 878/878 (100%)

Query: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60
           MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
Sbjct: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60

Query: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120
           NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
Sbjct: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120

Query: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV 180
           AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
Sbjct: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV 180

Query: 181 QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV 240
           QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
Sbjct: 181 QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV 240

Query: 241 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL 300
           FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
Sbjct: 241 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL 300

Query: 301 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK 360
           LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
Sbjct: 301 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK 360

Query: 361 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH 420
           EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
Sbjct: 361 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH 420

Query: 421 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFY 480
           TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFY
Sbjct: 421 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFY 480

Query: 481 LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC 540
           LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC
Sbjct: 481 LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC 540

Query: 541 KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN 600
           KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN
Sbjct: 541 KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN 600

Query: 601 PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR 660
           PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR
Sbjct: 601 PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR 660

Query: 661 PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI 720
           PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI
Sbjct: 661 PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI 720

Query: 721 KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR 780
           KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR
Sbjct: 721 KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR 780

Query: 781 SPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREG 840
           SPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREG
Sbjct: 781 SPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREG 840

Query: 841 DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ 878
           DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
Sbjct: 841 DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ 878


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 1696 bits (4392), Expect = 0.0
 Identities = 839/878 (95%), Positives = 839/878 (95%), Gaps = 39/878 (4%)

Query: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60
           MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
Sbjct: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60

Query: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120
           NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
Sbjct: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120

Query: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV 180
           AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
Sbjct: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV 180

Query: 181 QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV 240
           QQPM     KMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
Sbjct: 181 QQPM-----KMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV 235

Query: 241 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL 300
           FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
Sbjct: 236 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL 295

Query: 301 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK 360
           LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
Sbjct: 296 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK 355

Query: 361 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH 420
           EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
Sbjct: 356 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH 415

Query: 421 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFY 480
           TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKK     WSYGFY
Sbjct: 416 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKK-----WSYGFY 470

Query: 481 LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC 540
           LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC
Sbjct: 471 LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC 530

Query: 541 KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN 600
           KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN
Sbjct: 531 KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN 590

Query: 601 PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR 660
           PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR
Sbjct: 591 PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR 650

Query: 661 PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI 720
           PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI
Sbjct: 651 PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI 710

Query: 721 KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR 780
           KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR
Sbjct: 711 KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR 770

Query: 781 SPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREG 840
           SP                             VFTPRVIGTAVARYNFAARDMRELSLREG
Sbjct: 771 SP-----------------------------VFTPRVIGTAVARYNFAARDMRELSLREG 801

Query: 841 DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ 878
           DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
Sbjct: 802 DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ 839


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score =  917 bits (2371), Expect = 0.0
 Identities = 465/897 (51%), Positives = 623/897 (69%), Gaps = 73/897 (8%)

Query: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60
           ME W+QC +WLI CKVLP NHRV W SA VFDLAQ LRDGVLLCQLL+NL   SI+LK+I
Sbjct: 1   MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI 60

Query: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120
           N RPQMSQFLCLKNIRTFL  C + FG+R SELF+ FDLFDVRDFGKVI  +SRLS   I
Sbjct: 61  NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI 120

Query: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEH--DLGEDIYDCVPCEDGGDDIYEDIIKV 178
           A   GIRPFP+EE+  ND+D+Y+ L +L DE   +  ED+YDCV  ED G ++YED++K 
Sbjct: 121 ALATGIRPFPTEESI-NDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKA 179

Query: 179 E-VQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADM 237
           E   QP           E+D R+CCL EI++TE KY  TLE IEK +M+PL+  L+ A+ 
Sbjct: 180 EEAHQPKC--------PENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEF 231

Query: 238 AAVFINLEDLIKVHHSFLRAIDVSVM-VGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNT 296
            +VFIN+ +L+K+H + ++ I  S++      L +VF+++KERL+IYG+YCS +E A ++
Sbjct: 232 DSVFINIPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISS 291

Query: 297 LNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPER 356
           L+ +  ++ED + K+EEC+ +  +GKF L+DLLVVPMQRVLKYHLLL+EL+ H+ +  E+
Sbjct: 292 LDYISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEK 351

Query: 357 QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRS 416
             LK AL+AM+DLA Y+NEVKRD ETLR+I +FQ SIENL   +  FGRP+ DGE+++ +
Sbjct: 352 ANLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITT 411

Query: 417 IVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWS 476
           +  HTKQ+R++FLFD  VIVCKRKG +YE+KEII+L  +K+ ++P  +K+ KK     WS
Sbjct: 412 LDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKK-----WS 466

Query: 477 YGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTN 536
           YGFYLIH QG+ G +F+CKT+D+K+KW+EQFEMA+SNI+PD A++N H F+M+TF + T+
Sbjct: 467 YGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTS 526

Query: 537 CKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPC---------------KFTSPADLD 581
           CK C+M LRGTFYQGY+C KCG  AHKECL  +  C               K T+     
Sbjct: 527 CKVCQMLLRGTFYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRT 586

Query: 582 ASGAGPG-PKMVAMQNYHGNPAPP--GKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRK 638
                PG PKM  ++NY G P P     P L  Q GD +ELL+GD  S +W+GR + + +
Sbjct: 587 PKQVDPGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGE 646

Query: 639 SGYFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIR 698
            G+FPS +VKPCP   +P         +DY+  PW+AG MER Q +  L +  + TYL+R
Sbjct: 647 VGFFPSDAVKPCPCVPKP---------VDYSCQPWYAGAMERLQAETELINRVNSTYLVR 697

Query: 699 ERPAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQ 758
            R  E+  +AISIK+N+E KHIK++ +D + HI E +KF SL+ELVEYY+ HSLKE F+ 
Sbjct: 698 HRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRT 757

Query: 759 LDTTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVI 818
           LDTTL++PYK  E SA +  +R+                             S+ +P+V+
Sbjct: 758 LDTTLQFPYKEPEHSAGQRGNRAGN---------------------------SLLSPKVL 790

Query: 819 GTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEE 875
           G A+ARY+F ARDMRELSL +GDVV+IY+++  + GWW+GE NGR+GWFPSTYVEE+
Sbjct: 791 GIAIARYDFCARDMRELSLLKGDVVKIYTKMSAN-GWWRGEVNGRVGWFPSTYVEED 846


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score =  854 bits (2206), Expect = 0.0
 Identities = 441/895 (49%), Positives = 589/895 (65%), Gaps = 75/895 (8%)

Query: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60
           ME WRQC  WLI C+VLPP+HRV W  A V +LAQALRDGVLLCQLL+NL P +I+L+++
Sbjct: 1   MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60

Query: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120
           N RPQMSQFLCLKNIRTFL  C +KFGL+ SELF+ FDLFDV+DFGKVI  +S LS   I
Sbjct: 61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120

Query: 121 AQNKGIRPFPSEETTENDDDVYRSL-EELADEHDLGEDIYDCVPCEDG-GDDIYEDIIKV 178
           AQN+GI PFP+EE +  D+D+Y  L +++ D  +  ED+YDCV  E+  GD+IYED+++ 
Sbjct: 121 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180

Query: 179 E-VQQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADM 237
           E V  P         MTE DKR CCL EIQ+TE KY  TL  I+++++ PL+  L P D+
Sbjct: 181 EPVSMPP-------KMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDI 233

Query: 238 AAVFINLEDLIKVHHSFLRAIDVSVMV-GGSTLAKVFLDFKERLLIYGEYCSHMEHAQNT 296
             +FIN+EDL++VH  FL+ +  ++   G + L +VF+ +KER L+YG YCS +E A   
Sbjct: 234 EIIFINIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKH 293

Query: 297 LNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPER 356
           L+++ A+RED + K+EEC+ +  +G+F L+DLL+VPMQRVLKYHLLL+EL+ H+ E  E+
Sbjct: 294 LDRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEK 353

Query: 357 QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRS 416
           + L+ AL+AM+DLA  +NEVKRD ETLR+I+ FQ SIENL   L  +GRPKIDGELK+ S
Sbjct: 354 ENLRLALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITS 413

Query: 417 IVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWS 476
           +   +K DRY FL DK +++CKR+G SY+LK+ + L   ++ DD   ++D KK     WS
Sbjct: 414 VERRSKMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKK-----WS 468

Query: 477 YGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTN 536
           + F LI  QG QG++ F KT ++K+KWMEQFEMA+SNI P+ A AN H FQM++F++TT+
Sbjct: 469 HMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTS 528

Query: 537 CKACKMFLRGTFYQGYMCTKCGVGAHKECLEVIPPC--------------KFTSPADLDA 582
           CKAC+M LRGTFYQGY C +C   AHKECL  +PPC              K    A    
Sbjct: 529 CKACQMLLRGTFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKK 588

Query: 583 SGAGPGPKMVAMQNYHGNPAPPGK--PVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSG 640
                 PKM   Q Y+G P PPG   P L    GD++EL + + E  WWEGR   T + G
Sbjct: 589 RNELGLPKMEVFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIG 648

Query: 641 YFPSSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRER 700
           +FP + VKP        +  PP    D + + W+AG MER   +++L + + GT+L+R+R
Sbjct: 649 WFPCNRVKPY-------VHGPPQ---DLSVHLWYAGPMERAGAESILANRSDGTFLVRQR 698

Query: 701 PAEAERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLD 760
             +A  FAISIK+N EVKHIK++  +    ITE K F  L ELVE+YQ +SLK+ FK LD
Sbjct: 699 VKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLD 758

Query: 761 TTLKYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGT 820
           TTL++P+K  E+   R  SR       Y                              GT
Sbjct: 759 TTLQFPFKEPEK---RTISRPAVGSTKY-----------------------------FGT 786

Query: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEE 875
           A ARY+F ARD  ELSL+EGD+++I ++  G QGWW+GE  GR+GWFP+ YVEE+
Sbjct: 787 AKARYDFCARDRSELSLKEGDIIKILNK-KGQQGWWRGEIYGRVGWFPANYVEED 840


>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 287

 Score =  268 bits (684), Expect = 2e-71
 Identities = 136/292 (46%), Positives = 187/292 (64%), Gaps = 40/292 (13%)

Query: 587 PG-PKMVAMQNYHGNPAPP--GKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFP 643
           PG PKM  ++NY G P P     P L  Q GD +ELL+GD  S +W+GR + + + G+FP
Sbjct: 32  PGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFP 91

Query: 644 SSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAE 703
           S +VKPCP   +P         +DY+  PW+AG MER Q +  L +  + TYL+R R  E
Sbjct: 92  SDAVKPCPCVPKP---------VDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKE 142

Query: 704 AERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTL 763
           +  +AISIK+N+E KHIK++ +D + HI E +KF SL+ELVEYY+ HSLKE F+ LDTTL
Sbjct: 143 SGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTL 202

Query: 764 KYPYKSRERSASRASSRSPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVA 823
           ++PYK  E SA +  +R+                             S+ +P+V+G A+A
Sbjct: 203 QFPYKEPEHSAGQRGNRAGN---------------------------SLLSPKVLGIAIA 235

Query: 824 RYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEE 875
           RY+F ARDMRELSL +GDVV+IY+++  + GWW+GE NGR+GWFPSTYVEE+
Sbjct: 236 RYDFCARDMRELSLLKGDVVKIYTKMSAN-GWWRGEVNGRVGWFPSTYVEED 286


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score =  110 bits (275), Expect = 6e-24
 Identities = 98/335 (29%), Positives = 156/335 (46%), Gaps = 32/335 (9%)

Query: 199 RNCCLLEIQETEAKYYRTLEDIEKNYMSPL-RLVLSPAD-------MAAVFINLEDLIKV 250
           R C L E+Q+TE  Y  TLE +   ++  + +   S  D       +  +F N+ED++ V
Sbjct: 24  RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAV 83

Query: 251 HHSFLRAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 307
           H  FL+ ++  +    +   +V   FL FK++  IY EYCS+ E AQ  L +L   R   
Sbjct: 84  HKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRT-I 142

Query: 308 RQKVEECTLKV--QDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAER-PERQQLKEALE 364
           R  +  C L    ++    L+  LV P+QR+ KY L+LKELL  +  +  +   + EAL+
Sbjct: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202

Query: 365 AMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTK 422
           AM+ +   INE KR  E L  + E+QS IE  +     +      + G L    I +   
Sbjct: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVL--LKISSGNI 260

Query: 423 QDRYLFLFDKVVIVCKRK------------GYSYELKEIIELLFHKMTDDPMNNKDVKKS 470
           Q+R  FLFD +++ CKRK            G+ Y  +  I     ++ +      D   S
Sbjct: 261 QERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSS 320

Query: 471 HGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWME 505
            G +   G+ + +    + F    KT + K +W E
Sbjct: 321 -GHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFE 354


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score =  110 bits (275), Expect = 6e-24
 Identities = 98/335 (29%), Positives = 156/335 (46%), Gaps = 32/335 (9%)

Query: 199 RNCCLLEIQETEAKYYRTLEDIEKNYMSPL-RLVLSPAD-------MAAVFINLEDLIKV 250
           R C L E+Q+TE  Y  TLE +   ++  + +   S  D       +  +F N+ED++ V
Sbjct: 24  RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAV 83

Query: 251 HHSFLRAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 307
           H  FL+ ++  +    +   +V   FL FK++  IY EYCS+ E AQ  L +L   R   
Sbjct: 84  HKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRT-I 142

Query: 308 RQKVEECTLKV--QDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAER-PERQQLKEALE 364
           R  +  C L    ++    L+  LV P+QR+ KY L+LKELL  +  +  +   + EAL+
Sbjct: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202

Query: 365 AMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTK 422
           AM+ +   INE KR  E L  + E+QS IE  +     +      + G L    I +   
Sbjct: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVL--LKISSGNI 260

Query: 423 QDRYLFLFDKVVIVCKRK------------GYSYELKEIIELLFHKMTDDPMNNKDVKKS 470
           Q+R  FLFD +++ CKRK            G+ Y  +  I     ++ +      D   S
Sbjct: 261 QERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSS 320

Query: 471 HGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWME 505
            G +   G+ + +    + F    KT + K +W E
Sbjct: 321 -GHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFE 354


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  109 bits (272), Expect = 1e-23
 Identities = 97/341 (28%), Positives = 159/341 (46%), Gaps = 39/341 (11%)

Query: 199 RNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLV--------LSPADMAAVFINLEDLIKV 250
           R C L EI  TE  Y  TL  ++  ++  +R          L+  ++  +F N+ED+++V
Sbjct: 50  RLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEV 109

Query: 251 HHSFLRAIDVSVMVGGST---LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 307
           H  FL A++  +     +   L  VFL FK++  +Y EYCS+ E A   L +L       
Sbjct: 110 HKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVEL-NKIPTV 168

Query: 308 RQKVEECTL----KVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHS-AERPERQQLKEA 362
           R  +  C L    K  D    L+  L+ P+QR+ KY LLLKEL   +  + P+   ++ A
Sbjct: 169 RAFLLSCMLLGGRKTTD--IPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSA 226

Query: 363 LEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNH 420
           L+AM+ +   INE KR  E L  + + QS IE  +     +   +  + G L   S  N 
Sbjct: 227 LQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGN- 285

Query: 421 TKQDRYLFLFDKVVIVCKRKG----------YSYELKEIIELLFHKMTDDPMNNKDVKKS 470
             Q+R  FLFD +++ CKRK            +  +   + +   ++  + M  ++V+  
Sbjct: 286 -IQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDG 344

Query: 471 HGKMWSYGF-----YLIHLQGK-QGFQFFCKTEDMKRKWME 505
                S G+     + IH   K + F    KT + K+KW++
Sbjct: 345 TADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLD 385


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score =  106 bits (264), Expect = 1e-22
 Identities = 81/253 (32%), Positives = 129/253 (50%), Gaps = 14/253 (5%)

Query: 205 EIQETEAKYYRTLEDIEKNYMSPLR----LVLSPADMAAVFINLEDLIKVHHSFLRAIDV 260
           EI ETE  Y R L  I ++Y+ PL     L LS   +  +F N+ED+ +     L  ++ 
Sbjct: 109 EIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLEN 168

Query: 261 SVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQD 320
           S   GG  +A+ F+   E   IY  YC +   +   L +L  S       ++E   +++ 
Sbjct: 169 SSSAGG--IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLS-PPAALWLQERQAQLRH 225

Query: 321 GKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERP---ERQQLKEALEAMQDLAMYINEVK 377
               LQ  L+ P+QR+LKYHLLL+EL  H AE P    R+ ++EA+ +M  +A YIN++K
Sbjct: 226 S-LPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMK 284

Query: 378 RDKETLRKISEFQSSIEN-LQVKLEEFGRPKIDGELKVRSIVNHTKQ--DRYLFLFDKVV 434
           R +E   ++ E Q  +      +L  FG   ++G  +         +  +R LFLF +++
Sbjct: 285 RKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRML 344

Query: 435 IVCKRKGYSYELK 447
           +V KR+G  Y  K
Sbjct: 345 LVAKRRGLEYTYK 357


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score =  104 bits (260), Expect = 3e-22
 Identities = 94/338 (27%), Positives = 158/338 (46%), Gaps = 29/338 (8%)

Query: 199 RNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKVHHSFL 255
           R   + EI +TE  Y + L DI + Y+   R    + + A +A +F N+ED+ K    FL
Sbjct: 241 RTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFL 300

Query: 256 RAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVE 312
           + ++         L+++   FL  +E   IY EYC++   A   L  L+   + +R   E
Sbjct: 301 KDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGK-YRHFFE 359

Query: 313 ECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQDLAM 371
            C L  Q     +   L+ P+Q++ KY L L ELL ++  E  +   +K A EAM+++A 
Sbjct: 360 ACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVAC 419

Query: 372 YINEVKRDKETLRKISEFQSSI---ENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLF 428
            INE KR  E++ KI+ +Q SI   E L + L+        GEL  +       Q R  F
Sbjct: 420 LINERKRKLESIDKIARWQVSIVGWEGLDI-LDRSSELIHSGEL-TKITKQGKSQQRTFF 477

Query: 429 LFDKVVIVCKRKGYSYELKEII--ELLFHK--MTDDPMNNKDVKKSHGKMWSY----GFY 480
           LFD  ++ CK        K+++  ++L++K  +  D M   D+     K  +      F 
Sbjct: 478 LFDHQLVSCK--------KDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFK 529

Query: 481 LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK 518
           L+     + + F  K ++ K +W++        ++ DK
Sbjct: 530 LVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDK 567



 Score = 37.7 bits (86), Expect = 0.047
 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)

Query: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 872
           A A ++    D +EL  + GDV+++      D  WW G +  +  WFP+++V
Sbjct: 152 AEALWDHVTMDDQELGFKAGDVIQVLEASNKD--WWWGRSEDKEAWFPASFV 201


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score =  100 bits (250), Expect = 5e-21
 Identities = 72/252 (28%), Positives = 136/252 (53%), Gaps = 19/252 (7%)

Query: 205 EIQETEAKYYRTLEDIEKNYMSPLR----LVLSPADMAAVFINLEDLIKVHHSFLRAIDV 260
           EI ETE  Y + L+ I ++Y+  +R    L L   + +A+F N++D+   +   L+ ++ 
Sbjct: 120 EILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLE- 178

Query: 261 SVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASR---EDFRQKVEECTLK 317
           +       +A+ F+   E   IY +YC++   +   L + + ++   + FR++ E  TLK
Sbjct: 179 NCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQE--TLK 236

Query: 318 VQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQ-LKEALEAMQDLAMYINEV 376
                  L   L+ P+QR+LKYHLLL E+ +H  +  E    + +A++ MQ +A +IN++
Sbjct: 237 ---HSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDM 293

Query: 377 KRDKETLRKISEFQSSIENLQ-VKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVI 435
           KR  E   ++ E QS + N +   L  +G   ++G  +++      K +R LFLFDK+++
Sbjct: 294 KRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQ----RAKNERTLFLFDKLLL 349

Query: 436 VCKRKGYSYELK 447
           + K++  ++  K
Sbjct: 350 ITKKRDDTFTYK 361


>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 87/343 (25%), Positives = 158/343 (46%), Gaps = 32/343 (9%)

Query: 196 DDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKVHH 252
           D  R   + EI  TE  Y + L+DI + Y+   R    + S   +  +F N+ED+ +   
Sbjct: 101 DQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQM 160

Query: 253 SFLRAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ 309
            F+R ++         L+++   FL+ ++   IY EYC++   A   L++L+     ++ 
Sbjct: 161 GFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSR-YQH 219

Query: 310 KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQD 368
             E C L  Q     +   L+ P+Q++ KY L L ELL ++A +  + + +  AL  M++
Sbjct: 220 FFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRN 279

Query: 369 LAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTKQDRY 426
           +   INE KR  E + KI+++Q+S+ + + +  L+        GE+          Q R 
Sbjct: 280 VTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRV 339

Query: 427 LFLFDKVVIVCKR----------KG-YSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMW 475
            FLFD  +++CK+          KG    +  E++++   +  D  ++ K+  K H K  
Sbjct: 340 FFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKET 399

Query: 476 SYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK 518
                 IHL       FF K  + K +W+  F      ++ D+
Sbjct: 400 EE----IHL-------FFAKKLEEKIRWLRAFREERKMVQEDE 431



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 18/55 (32%), Positives = 31/55 (56%), Gaps = 2/55 (3%)

Query: 818 IGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 872
           I +A A ++      REL+ + GDV+++      D  WW G+ +   GWFP+++V
Sbjct: 10  IVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKD--WWWGQIDDEEGWFPASFV 62


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 78/257 (30%), Positives = 126/257 (49%), Gaps = 14/257 (5%)

Query: 194 TEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKV 250
           ++D  R   + EI  TE  Y + L DI + Y+   R    + S   +  +F N+ED+ + 
Sbjct: 280 SKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRC 339

Query: 251 HHSFLRAIDVSVMVGG---STLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 307
             +F++A++          S L   FL+ +    IY EYC++  +A   L++L      +
Sbjct: 340 QKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRL-TKLSKY 398

Query: 308 RQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKE---ALE 364
               E C L  +     L   L+ P+Q++ KY L L ELL ++   P+ +  K+   AL 
Sbjct: 399 VYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYT--HPQHRDFKDVEAALH 456

Query: 365 AMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTK 422
           AM+++A  INE KR  E + KI+++QSSIE+ + +  L         GEL   +      
Sbjct: 457 AMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKS 516

Query: 423 QDRYLFLFDKVVIVCKR 439
           Q R  FLFD  +I CK+
Sbjct: 517 QQRMFFLFDHQLIYCKK 533



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 872
           A A ++    D +EL  + GDV+ +      +  WW G      GWFP+++V
Sbjct: 199 AEALWDHVTMDDQELGFKAGDVIEVMDATNRE--WWWGRVADGEGWFPASFV 248


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 78/257 (30%), Positives = 126/257 (49%), Gaps = 14/257 (5%)

Query: 194 TEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKV 250
           ++D  R   + EI  TE  Y + L DI + Y+   R    + S   +  +F N+ED+ + 
Sbjct: 280 SKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRC 339

Query: 251 HHSFLRAIDVSVMVGG---STLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 307
             +F++A++          S L   FL+ +    IY EYC++  +A   L++L      +
Sbjct: 340 QKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRL-TKLSKY 398

Query: 308 RQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKE---ALE 364
               E C L  +     L   L+ P+Q++ KY L L ELL ++   P+ +  K+   AL 
Sbjct: 399 VYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYT--HPQHRDFKDVEAALH 456

Query: 365 AMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTK 422
           AM+++A  INE KR  E + KI+++QSSIE+ + +  L         GEL   +      
Sbjct: 457 AMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKS 516

Query: 423 QDRYLFLFDKVVIVCKR 439
           Q R  FLFD  +I CK+
Sbjct: 517 QQRMFFLFDHQLIYCKK 533



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 872
           A A ++    D +EL  + GDV+ +      +  WW G      GWFP+++V
Sbjct: 199 AEALWDHVTMDDQELGFKAGDVIEVMDATNRE--WWWGRVADGEGWFPASFV 248


>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
          Length = 217

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 72/267 (26%)

Query: 609 LTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDY 668
           L F  GD L++L  + +  W++  L      G+ P + ++  P                 
Sbjct: 17  LAFNKGDTLKILNMEDDQNWYKAELRGVE--GFIPKNYIRVKP----------------- 57

Query: 669 TAYPWFAGNMERQQTDNLL-KSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN 727
             +PW++G + RQ  + +L K +  G +LIRE  +    F++S+ + D+V+H KV+ + +
Sbjct: 58  --HPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREAS 115

Query: 728 WIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASC-A 786
             +    +KF+SL ELV++Y+  ++ +  +Q+    + P             +SP +C A
Sbjct: 116 GKYFLWEEKFNSLNELVDFYRTTTIAKK-RQIFLRDEEPL-----------LKSPGACFA 163

Query: 787 SYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIY 846
              F F                                   +A+D  +LS R GD++ + 
Sbjct: 164 QAQFDF-----------------------------------SAQDPSQLSFRRGDIIEVL 188

Query: 847 SRIGGDQGWWKGETNGRIGWFPSTYVE 873
            R   D  WW+G + GR+G+FP +YV+
Sbjct: 189 ER--PDPHWWRGRSCGRVGFFPRSYVQ 213



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 19/52 (36%), Positives = 31/52 (59%), Gaps = 1/52 (1%)

Query: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 872
           +VA Y+F A +  EL+  +GD ++I + +  DQ W+K E  G  G+ P  Y+
Sbjct: 3   SVALYSFQATESDELAFNKGDTLKILN-MEDDQNWYKAELRGVEGFIPKNYI 53


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 72/271 (26%), Positives = 131/271 (48%), Gaps = 27/271 (9%)

Query: 197  DKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLR-----LVLSPADMAAVFINLEDLIKVH 251
            D R    + + +TE  Y  +L  + + YM PL+     ++  P+ +  +F  + +L++ H
Sbjct: 1065 DMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHH 1124

Query: 252  HSFLRAIDVSVMVG------GSTLAKVFLDFKERLL-IYGEYCSHMEHAQNTLNQLLASR 304
              FL  +   +         G+ L + F   K+ L+ IY  Y  +  +A++ +     +R
Sbjct: 1125 EQFLEQVRHCMQTWHAQQKVGALLVQSFS--KDVLVNIYSAYIDNFLNAKDAVRVAKEAR 1182

Query: 305  EDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAE-RPERQQLKEAL 363
              F + +E+ +++    K  L DL++ P+QR+ +Y LL+K+LL H+ E  P+   L EA 
Sbjct: 1183 PAFLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQ 1241

Query: 364  EAMQDLAMYIN-------EVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRS 416
              ++ +A  IN       E +R    L++I      +E+LQ  L  F R ++  E+K   
Sbjct: 1242 RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG 1301

Query: 417  IVNHTKQDRYLFLFDKVVIVCKRKGYSYELK 447
                 K+DR LFLF  +++    K  S  L+
Sbjct: 1302 ----GKKDRSLFLFTDLIVCTTLKRKSGSLR 1328


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 63/265 (23%), Positives = 107/265 (40%), Gaps = 72/265 (27%)

Query: 609 LTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDY 668
           L+F+ GD+L++L  + +  W++  L    K G+ P + ++  P                 
Sbjct: 17  LSFKRGDILKVLNEECDQNWYKAEL--NGKDGFIPKNYIEMKP----------------- 57

Query: 669 TAYPWFAGNMERQQTDNLL-KSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN 727
             +PWF G + R + + +L K    G +LIRE  +    F++S+KF ++V+H KV+    
Sbjct: 58  --HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGA 115

Query: 728 WIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPASCAS 787
             +     KF+SL ELV+Y++  S+  + +                              
Sbjct: 116 GKYFLWVVKFNSLNELVDYHRSTSVSRNQQIF---------------------------- 147

Query: 788 YNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYS 847
                     L    Q P  P +            A ++F  ++  EL  R GD + +  
Sbjct: 148 ----------LRDIEQVPQQPTY----------VQALFDFDPQEDGELGFRRGDFIHVMD 187

Query: 848 RIGGDQGWWKGETNGRIGWFPSTYV 872
               D  WWKG  +G+ G FP  YV
Sbjct: 188 --NSDPNWWKGACHGQTGMFPRNYV 210



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 1/53 (1%)

Query: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 873
           A+A+Y+F A    ELS + GD++++ +    DQ W+K E NG+ G+ P  Y+E
Sbjct: 3   AIAKYDFKATADDELSFKRGDILKVLNE-ECDQNWYKAELNGKDGFIPKNYIE 54


>gi|55749621 pleckstrin homology domain containing, family G, member
           3 [Homo sapiens]
          Length = 1163

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 63/249 (25%), Positives = 116/249 (46%), Gaps = 33/249 (13%)

Query: 282 IYGEYCSHMEHAQNTLNQLLASRED---FRQKVEECTLKVQDGKFKLQDLLVVPMQRVLK 338
           IY +YC++  ++   L + +  ++    FR + E     +  G + L+     P+QR+LK
Sbjct: 123 IYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLK-----PVQRILK 177

Query: 339 YHLLLKELLSHSAERPER-QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQ 397
           YHLLL+E+  H  E  +  + +++A++ M  +A YIN++KR  E   ++ E QS + N +
Sbjct: 178 YHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWK 237

Query: 398 -VKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHK 456
              L  +G   ++G  +V  + N    +R  FLFDK +++ K++G  +  K  I      
Sbjct: 238 GPDLTTYGELVLEGTFRVHRVRN----ERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLM 293

Query: 457 MTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKP 516
           + +   ++     +H K             KQ +    KT + KR W    +  +     
Sbjct: 294 LIESTRDSLCFTVTHYK-----------HSKQQYSIQAKTVEEKRNWTHHIKRLILE--- 339

Query: 517 DKANANHHS 525
                NHH+
Sbjct: 340 -----NHHA 343


>gi|224586880 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 3 [Homo sapiens]
          Length = 1257

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 79/349 (22%), Positives = 155/349 (44%), Gaps = 32/349 (9%)

Query: 198 KRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPA-------DMAAVFINLEDLIKV 250
           KRN  +  + E EA+Y + L  +  N++ PLR+  S         D++++F+N E ++ +
Sbjct: 240 KRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFL 299

Query: 251 HHSFLRAIDVSVMVGGS-TLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ 309
           H  F + +   +    +  LA +F      L IY E+  + +++   L     +R DF +
Sbjct: 300 HQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNR-DFDK 358

Query: 310 KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQD 368
            ++    K    +  L+  L  PM ++ +Y L L ELL+H+  E  ER  L  A   +++
Sbjct: 359 LLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEE 418

Query: 369 LAMYINEVKRDKETLRK-ISEFQSSIENLQVKLEEFGRPKIDGEL--------------K 413
           L+  +++   + E +RK ++  +  IE  ++ L+        G L              +
Sbjct: 419 LSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGR 478

Query: 414 VRSIVNHTKQDRYLFLFDKVVIVCKR-KGYSYELKE--IIELLFHKMTDDPMNNKDVKKS 470
           + S+    + +R  FLF K +I+C R  G    L +  +I L+   + ++P + ++  K 
Sbjct: 479 LGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKG 538

Query: 471 HGKMWSYGFYLIHLQGKQGFQF----FCKTEDMKRKWMEQFEMAMSNIK 515
            G+   +  + I ++ K    F       +   K  W       + NI+
Sbjct: 539 SGQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIR 587


>gi|24797099 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 1 [Homo sapiens]
          Length = 1273

 Score = 80.1 bits (196), Expect = 8e-15
 Identities = 79/349 (22%), Positives = 155/349 (44%), Gaps = 32/349 (9%)

Query: 198 KRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPA-------DMAAVFINLEDLIKV 250
           KRN  +  + E EA+Y + L  +  N++ PLR+  S         D++++F+N E ++ +
Sbjct: 240 KRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFL 299

Query: 251 HHSFLRAIDVSVMVGGS-TLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ 309
           H  F + +   +    +  LA +F      L IY E+  + +++   L     +R DF +
Sbjct: 300 HQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNR-DFDK 358

Query: 310 KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQD 368
            ++    K    +  L+  L  PM ++ +Y L L ELL+H+  E  ER  L  A   +++
Sbjct: 359 LLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEE 418

Query: 369 LAMYINEVKRDKETLRK-ISEFQSSIENLQVKLEEFGRPKIDGEL--------------K 413
           L+  +++   + E +RK ++  +  IE  ++ L+        G L              +
Sbjct: 419 LSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGR 478

Query: 414 VRSIVNHTKQDRYLFLFDKVVIVCKR-KGYSYELKE--IIELLFHKMTDDPMNNKDVKKS 470
           + S+    + +R  FLF K +I+C R  G    L +  +I L+   + ++P + ++  K 
Sbjct: 479 LGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKG 538

Query: 471 HGKMWSYGFYLIHLQGKQGFQF----FCKTEDMKRKWMEQFEMAMSNIK 515
            G+   +  + I ++ K    F       +   K  W       + NI+
Sbjct: 539 SGQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIR 587


>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 618

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 65/272 (23%), Positives = 127/272 (46%), Gaps = 37/272 (13%)

Query: 195 EDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSP--LRLVLSPADMAAVFINLEDLIKVHH 252
           E+ K    + E+  +EA YY++L  +  ++M    +R +L P++   +F N+ D++ V  
Sbjct: 178 EEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSE 237

Query: 253 SFLRAIDVSV---MVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ 309
            FL  ++  +   +V       V+    +   +Y  Y S+  + + T  QLL  +  FR+
Sbjct: 238 RFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRE 297

Query: 310 KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDL 369
            + +  L  +         L++P QR+ +  LL++ +L    ER ER+    AL+A ++L
Sbjct: 298 LIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERE--CTALDAHKEL 355

Query: 370 AMYINEVKRDKETLRKISEFQSSIENLQVKLE----------------------EFGRPK 407
            M    VK   E +RK+S  +  I ++Q K+E                      +   PK
Sbjct: 356 EMV---VKACNEGVRKMSRTEQMI-SIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPK 411

Query: 408 IDGELKVRSIVNHTKQDRYLFLFDKVVIVCKR 439
               L+ + + +    + YLFLF+ ++++C++
Sbjct: 412 TSRTLRTKKLFH----EIYLFLFNDLLVICRQ 439



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)

Query: 813 FTPRVIGTAVAR--YNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGET--NGRIGWFP 868
           FT R++     +  + + A+   EL+L   D++ I  +   D GW  GE   +   GWFP
Sbjct: 515 FTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKT--DDGWIFGERLHDQERGWFP 572

Query: 869 STYVEE 874
           S+  EE
Sbjct: 573 SSMTEE 578


>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 710

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 65/272 (23%), Positives = 127/272 (46%), Gaps = 37/272 (13%)

Query: 195 EDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSP--LRLVLSPADMAAVFINLEDLIKVHH 252
           E+ K    + E+  +EA YY++L  +  ++M    +R +L P++   +F N+ D++ V  
Sbjct: 270 EEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSE 329

Query: 253 SFLRAIDVSV---MVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ 309
            FL  ++  +   +V       V+    +   +Y  Y S+  + + T  QLL  +  FR+
Sbjct: 330 RFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRE 389

Query: 310 KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEAMQDL 369
            + +  L  +         L++P QR+ +  LL++ +L    ER ER+    AL+A ++L
Sbjct: 390 LIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERE--CTALDAHKEL 447

Query: 370 AMYINEVKRDKETLRKISEFQSSIENLQVKLE----------------------EFGRPK 407
            M    VK   E +RK+S  +  I ++Q K+E                      +   PK
Sbjct: 448 EMV---VKACNEGVRKMSRTEQMI-SIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPK 503

Query: 408 IDGELKVRSIVNHTKQDRYLFLFDKVVIVCKR 439
               L+ + + +    + YLFLF+ ++++C++
Sbjct: 504 TSRTLRTKKLFH----EIYLFLFNDLLVICRQ 531



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)

Query: 813 FTPRVIGTAVAR--YNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGET--NGRIGWFP 868
           FT R++     +  + + A+   EL+L   D++ I  +   D GW  GE   +   GWFP
Sbjct: 607 FTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKT--DDGWIFGERLHDQERGWFP 664

Query: 869 STYVEE 874
           S+  EE
Sbjct: 665 SSMTEE 670


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 73/335 (21%), Positives = 143/335 (42%), Gaps = 27/335 (8%)

Query: 205 EIQETEAKYYRTLEDIEKNYMSPLRLV-LSPADMAAVFINLEDLIKVHHSFLRA-IDVSV 262
           E+  TE  Y + L  +++ + + L    + P  +  +F N+  + + H  FL   +   +
Sbjct: 164 ELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRI 223

Query: 263 MVGGST---LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQ 319
                T   L  +       L +YGEY  + + A   ++        F+  V     +  
Sbjct: 224 TEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283

Query: 320 DGKFKLQDLLVVPMQRVLKYHLLLKELLSH-SAERPERQQLKEALEAMQDLAMYINEVKR 378
            G   LQ  ++ P+QRV +Y LLLK+ L     + P+R+  + +LE +   A + N   R
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343

Query: 379 DKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCK 438
             E + K+ E    +   +  +        +G+++  S  N T QDR+LFLF+ +++ C 
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCV 403

Query: 439 RK----GYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFC 494
            K    G  + ++E       KM    +  +D+ K      +     I    K+  +   
Sbjct: 404 PKLRLMGQKFSVRE-------KMDISGLQVQDIVKP-----NTAHTFIITGRKRSLELQT 451

Query: 495 KTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMY 529
           +TE+ K++W++  +  +     +K   N  +F+ +
Sbjct: 452 RTEEEKKEWIQIIQATI-----EKHKQNSETFKAF 481


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 73/335 (21%), Positives = 143/335 (42%), Gaps = 27/335 (8%)

Query: 205 EIQETEAKYYRTLEDIEKNYMSPLRLV-LSPADMAAVFINLEDLIKVHHSFLRA-IDVSV 262
           E+  TE  Y + L  +++ + + L    + P  +  +F N+  + + H  FL   +   +
Sbjct: 164 ELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRI 223

Query: 263 MVGGST---LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQ 319
                T   L  +       L +YGEY  + + A   ++        F+  V     +  
Sbjct: 224 TEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283

Query: 320 DGKFKLQDLLVVPMQRVLKYHLLLKELLSH-SAERPERQQLKEALEAMQDLAMYINEVKR 378
            G   LQ  ++ P+QRV +Y LLLK+ L     + P+R+  + +LE +   A + N   R
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343

Query: 379 DKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCK 438
             E + K+ E    +   +  +        +G+++  S  N T QDR+LFLF+ +++ C 
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCV 403

Query: 439 RK----GYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFYLIHLQGKQGFQFFC 494
            K    G  + ++E       KM    +  +D+ K      +     I    K+  +   
Sbjct: 404 PKLRLMGQKFSVRE-------KMDISGLQVQDIVKP-----NTAHTFIITGRKRSLELQT 451

Query: 495 KTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMY 529
           +TE+ K++W++  +  +     +K   N  +F+ +
Sbjct: 452 RTEEEKKEWIQIIQATI-----EKHKQNSETFKAF 481


>gi|153791628 MCF.2 cell line derived transforming sequence isoform
           a [Homo sapiens]
          Length = 985

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 71/273 (26%), Positives = 120/273 (43%), Gaps = 36/273 (13%)

Query: 192 GMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMS----PLRLVLSPADMA----AVFIN 243
           G + D  +N  L E+ +TE  Y R L  +   Y +    P    L P  +      +F N
Sbjct: 549 GNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGN 608

Query: 244 LEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLAS 303
           + ++ + H+    +   +       +   FL+ K+   +Y +YC +   ++    +   S
Sbjct: 609 MAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKY--S 666

Query: 304 REDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEAL 363
              F Q   EC  K++  + +L   L+ P+QR+ KY LLLKELL +S +      LK+AL
Sbjct: 667 ECAFFQ---ECQRKLKH-RLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKAL 722

Query: 364 EAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKID-----------GEL 412
           +AM DL   +N+           S  Q +I      L E G+  +            G  
Sbjct: 723 DAMLDLLKSVND-----------SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGAT 771

Query: 413 KVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYE 445
           K++ +       R+LFL++K ++ CKR+  S E
Sbjct: 772 KMKDLARFKPMQRHLFLYEKAIVFCKRRVESGE 804


>gi|153791325 MCF.2 cell line derived transforming sequence isoform
           b [Homo sapiens]
          Length = 925

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 71/273 (26%), Positives = 120/273 (43%), Gaps = 36/273 (13%)

Query: 192 GMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMS----PLRLVLSPADMA----AVFIN 243
           G + D  +N  L E+ +TE  Y R L  +   Y +    P    L P  +      +F N
Sbjct: 489 GNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGN 548

Query: 244 LEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLAS 303
           + ++ + H+    +   +       +   FL+ K+   +Y +YC +   ++    +   S
Sbjct: 549 MAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKY--S 606

Query: 304 REDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEAL 363
              F Q   EC  K++  + +L   L+ P+QR+ KY LLLKELL +S +      LK+AL
Sbjct: 607 ECAFFQ---ECQRKLKH-RLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKAL 662

Query: 364 EAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKID-----------GEL 412
           +AM DL   +N+           S  Q +I      L E G+  +            G  
Sbjct: 663 DAMLDLLKSVND-----------SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGAT 711

Query: 413 KVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYE 445
           K++ +       R+LFL++K ++ CKR+  S E
Sbjct: 712 KMKDLARFKPMQRHLFLYEKAIVFCKRRVESGE 744


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 53/205 (25%), Positives = 99/205 (48%), Gaps = 8/205 (3%)

Query: 198  KRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL--VLSPADMAAVFINLEDLIKVHHSFL 255
            KR   + E+  TE  Y   L+ + + +  PL    +L+  ++A +F+N ++LI  +   L
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296

Query: 256  RAIDVSVMVGGSTL-AKVFLDFKERLLI----YGEYCSHMEHAQNTLNQLLASREDFRQK 310
            +A+ V   + G  +  K+  D     L     Y  +CS   +    + Q      DF++ 
Sbjct: 1297 KALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEF 1356

Query: 311  VEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAE-RPERQQLKEALEAMQDL 369
            V+   +  +     L   ++ PMQRV +Y L++K +L ++ E  P+   LK ALE  ++L
Sbjct: 1357 VKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEEL 1416

Query: 370  AMYINEVKRDKETLRKISEFQSSIE 394
               +NE  R+KE   ++   Q+ ++
Sbjct: 1417 CSQVNEGVREKENSDRLEWIQAHVQ 1441



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 19/52 (36%), Positives = 34/52 (65%), Gaps = 2/52 (3%)

Query: 822  VARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 873
            +  Y++ A++  EL+  +G ++ + ++   D  WWKGE NG++G FPS YV+
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNK--EDPDWWKGEVNGQVGLFPSNYVK 1210



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 5/57 (8%)

Query: 823 ARYNFAARDMRELSLREGDVVRIYSRI-----GGDQGWWKGETNGRIGWFPSTYVEE 874
           A Y F +R   E++++ GD+V +          G+ GW  GE  G+ GWFP+ Y E+
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 18/53 (33%), Positives = 28/53 (52%), Gaps = 3/53 (5%)

Query: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 873
           A A Y + A+    L+  + DV+ +  +      WW GE  G+ GWFP +YV+
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQ---QDMWWFGEVQGQKGWFPKSYVK 967



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 16/51 (31%), Positives = 28/51 (54%), Gaps = 3/51 (5%)

Query: 822  VARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 872
            +A Y + + +  +L+ ++GDV+ +  +   D  WW G    + G FPS YV
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVILVTKK---DGDWWTGTVGDKAGVFPSNYV 1055



 Score = 38.5 bits (88), Expect = 0.028
 Identities = 19/53 (35%), Positives = 29/53 (54%), Gaps = 7/53 (13%)

Query: 826  NFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGR-----IGWFPSTYVE 873
            ++ A    +L+L  G ++ I  +  G  GWW+GE   R     IGWFP+ YV+
Sbjct: 1084 SYTATGPEQLTLAPGQLILIRKKNPG--GWWEGELQARGKKRQIGWFPANYVK 1134


>gi|163644325 MCF.2 cell line derived transforming sequence-like
            isoform a [Homo sapiens]
          Length = 1182

 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 118/509 (23%), Positives = 207/509 (40%), Gaps = 89/509 (17%)

Query: 199  RNCCLLEIQETEAKYYRTLEDIEKNYMS----PLRLVLSPADMA----AVFINLEDLIKV 250
            R   + E+ +TE  Y   L  + + Y +    PL   L    +      +F N+E++   
Sbjct: 659  RRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHF 718

Query: 251  HHS-FLRAI----DVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE 305
            H+  FLR +    D   +VG     + FL+  E   IY +YC +   +++   Q   S  
Sbjct: 719  HNRIFLRELENYTDCPELVG-----RCFLERMEDFQIYEKYCQNKPRSESLWRQ--CSDC 771

Query: 306  DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA 365
             F Q   EC  K+ D K  L   L+ P+QR+ KY LLLKE+L +S      + L+EAL +
Sbjct: 772  PFFQ---ECQRKL-DHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSS 827

Query: 366  MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKI-----DGELKVRSIVNH 420
            +  +   +N    D   L  I+ +  ++ +L  KL   G   +      G  KV+ +   
Sbjct: 828  ILGILKAVN----DSMHLIAITGYDGNLGDLG-KLLMQGSFSVWTDHKRGHTKVKELARF 882

Query: 421  TKQDRYLFLFDKVVIVCKRK-----GY----SYELKEIIELLFHKMTDDPMNNKDVKKSH 471
                R+LFL +K V+ CK++     GY    SY  K+ + +    +T++     D KK  
Sbjct: 883  KPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKG--DAKK-- 938

Query: 472  GKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAM-SNIKPDKANANHHSFQM-- 528
                   F + +   ++ +     T ++K  W+ +    + S ++  +  + H + +   
Sbjct: 939  -------FEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQ 991

Query: 529  -----------------YTFDKTTNCKACKMFLRGTFY-----------QGYMCTKCGVG 560
                                 K    K   + L G              +G+  T   + 
Sbjct: 992  SLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLE 1051

Query: 561  AHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYH--GNPAPPGKPVLTFQTGDVLE 618
            A ++        +  + +D +  G G GPK +    Y    +    G   L  ++GDV+E
Sbjct: 1052 APEDDGGWSSAEEQINSSDAEEDG-GLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVE 1110

Query: 619  LLRGDPESPWWEGRLVQTRKSGYFPSSSV 647
            L++   E  W+  R   T K G+ P+SS+
Sbjct: 1111 LVQEGDEGLWYV-RDPTTGKEGWVPASSL 1138



 Score = 30.8 bits (68), Expect = 5.8
 Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 4/38 (10%)

Query: 835  LSLREGDVVRIYSRIGGDQGWW--KGETNGRIGWFPST 870
            L +R GDVV +     GD+G W  +  T G+ GW P++
Sbjct: 1101 LRVRSGDVVELVQE--GDEGLWYVRDPTTGKEGWVPAS 1136


>gi|163644323 MCF.2 cell line derived transforming sequence-like
            isoform b [Homo sapiens]
          Length = 1129

 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 118/509 (23%), Positives = 207/509 (40%), Gaps = 89/509 (17%)

Query: 199  RNCCLLEIQETEAKYYRTLEDIEKNYMS----PLRLVLSPADMA----AVFINLEDLIKV 250
            R   + E+ +TE  Y   L  + + Y +    PL   L    +      +F N+E++   
Sbjct: 606  RRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHF 665

Query: 251  HHS-FLRAI----DVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE 305
            H+  FLR +    D   +VG     + FL+  E   IY +YC +   +++   Q   S  
Sbjct: 666  HNRIFLRELENYTDCPELVG-----RCFLERMEDFQIYEKYCQNKPRSESLWRQ--CSDC 718

Query: 306  DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA 365
             F Q   EC  K+ D K  L   L+ P+QR+ KY LLLKE+L +S      + L+EAL +
Sbjct: 719  PFFQ---ECQRKL-DHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSS 774

Query: 366  MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKI-----DGELKVRSIVNH 420
            +  +   +N    D   L  I+ +  ++ +L  KL   G   +      G  KV+ +   
Sbjct: 775  ILGILKAVN----DSMHLIAITGYDGNLGDLG-KLLMQGSFSVWTDHKRGHTKVKELARF 829

Query: 421  TKQDRYLFLFDKVVIVCKRK-----GY----SYELKEIIELLFHKMTDDPMNNKDVKKSH 471
                R+LFL +K V+ CK++     GY    SY  K+ + +    +T++     D KK  
Sbjct: 830  KPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKG--DAKK-- 885

Query: 472  GKMWSYGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAM-SNIKPDKANANHHSFQM-- 528
                   F + +   ++ +     T ++K  W+ +    + S ++  +  + H + +   
Sbjct: 886  -------FEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQ 938

Query: 529  -----------------YTFDKTTNCKACKMFLRGTFY-----------QGYMCTKCGVG 560
                                 K    K   + L G              +G+  T   + 
Sbjct: 939  SLPLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLE 998

Query: 561  AHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYH--GNPAPPGKPVLTFQTGDVLE 618
            A ++        +  + +D +  G G GPK +    Y    +    G   L  ++GDV+E
Sbjct: 999  APEDDGGWSSAEEQINSSDAEEDG-GLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVE 1057

Query: 619  LLRGDPESPWWEGRLVQTRKSGYFPSSSV 647
            L++   E  W+  R   T K G+ P+SS+
Sbjct: 1058 LVQEGDEGLWYV-RDPTTGKEGWVPASSL 1085



 Score = 30.8 bits (68), Expect = 5.8
 Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 4/38 (10%)

Query: 835  LSLREGDVVRIYSRIGGDQGWW--KGETNGRIGWFPST 870
            L +R GDVV +     GD+G W  +  T G+ GW P++
Sbjct: 1048 LRVRSGDVVELVQE--GDEGLWYVRDPTTGKEGWVPAS 1083


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 82/295 (27%), Positives = 127/295 (43%), Gaps = 59/295 (20%)

Query: 133 ETTENDDDVYRS--------LEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPM 184
           E  E D D+Y          LEE  DE    E + D   CE   + +      +E+QQ  
Sbjct: 699 EEMERDLDMYSRAQEELNLMLEEKQDESSRAETLEDLKFCESNIESL-----NMELQQ-- 751

Query: 185 IRYMQKMGMTED-------------------DKRNCCLLEIQETEAKYYRTLEDIEKNYM 225
           +R M  +                        +KR   + E+ +TE  Y R LE   +  M
Sbjct: 752 LREMTLLSSQSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIM 811

Query: 226 SPLRLVLSP-ADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLL-IY 283
            P++    P  D   +F N++ +IKV    L A+++S  VG      VFL  ++ L   Y
Sbjct: 812 VPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALEISDAVG-----PVFLGHRDELEGTY 866

Query: 284 GEYCSHMEHA----------QNTLNQLLASREDFRQKVEE--CTLKVQDGKFKLQDLLVV 331
             YC + + A          +     L  S  D +    E  CT  +  G F     L+ 
Sbjct: 867 KIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSF-----LIK 921

Query: 332 PMQRVLKYHLLLKELLSHSAE-RPERQQLKEALEAMQDLAMYINEVKRDKETLRK 385
           P+QRV++Y LLL ELL+ + E  P++  L  A+ A++++ + INE KR K+ + K
Sbjct: 922 PVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKDLVLK 976



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 2/54 (3%)

Query: 823  ARYNFAARDMRELSLREGDVVRI--YSRIGGDQGWWKGETNGRIGWFPSTYVEE 874
            A Y F AR+  ELS+     ++I  +  + G+  WW  E NG+ G+ PS Y+ +
Sbjct: 1520 AVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRK 1573



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 25/57 (43%), Positives = 33/57 (57%), Gaps = 4/57 (7%)

Query: 818 IGTAVARYNFAARDMRELSLREGDVVRIYSRIG-GDQGWWKGETNGRIGWFPSTYVE 873
           +G A A    +A+   EL  REGDV+ I   IG  + GW++GE  GR G FP  +VE
Sbjct: 147 MGQARALMGLSAQLDEELDFREGDVITI---IGVPEPGWFEGELEGRRGIFPEGFVE 200



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 2/52 (3%)

Query: 822 VARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 873
           VA Y F A +  EL    GD +RI + +  + GW +G   GR G FP  +V+
Sbjct: 249 VALYRFQALEPNELDFEVGDKIRILATL--EDGWLEGSLKGRTGIFPYRFVK 298



 Score = 30.4 bits (67), Expect = 7.5
 Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 2/51 (3%)

Query: 823 ARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 873
           A ++F      EL L  GD++ + + +  D+ W  G+     G FPS++VE
Sbjct: 9   AIFDFCPSVSEELPLFVGDIIEVLAVV--DEFWLLGKKEDVTGQFPSSFVE 57


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,985,496
Number of Sequences: 37866
Number of extensions: 1698986
Number of successful extensions: 6833
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 310
Number of HSP's that attempted gapping in prelim test: 5673
Number of HSP's gapped (non-prelim): 1168
length of query: 878
length of database: 18,247,518
effective HSP length: 111
effective length of query: 767
effective length of database: 14,044,392
effective search space: 10772048664
effective search space used: 10772048664
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.