Guide to the Human Genome
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Search of human proteins with 19557645

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19557645 secretogranin III [Homo sapiens]
         (468 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19557645 secretogranin III [Homo sapiens]                          928   0.0  
gi|110815815 centlein isoform 1 [Homo sapiens]                         44   4e-04
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]         41   0.002
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]         41   0.002
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    41   0.003
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    41   0.003
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    41   0.003
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    41   0.003
gi|71061468 centromere protein E [Homo sapiens]                        40   0.003
gi|41281453 serine/threonine kinase 2 [Homo sapiens]                   40   0.006
gi|226497734 RNA binding motif protein 19 [Homo sapiens]               39   0.008
gi|226497654 RNA binding motif protein 19 [Homo sapiens]               39   0.008
gi|226497574 RNA binding motif protein 19 [Homo sapiens]               39   0.008
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    39   0.010
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1...    38   0.017
gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithor...    38   0.023
gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens]      37   0.029
gi|197313718 IQ motif containing G [Homo sapiens]                      37   0.029
gi|14165288 IQ motif containing G [Homo sapiens]                       37   0.029
gi|45439327 periplakin [Homo sapiens]                                  37   0.029
gi|118498362 kinectin 1 isoform b [Homo sapiens]                       37   0.050
gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H...    35   0.11 
gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo ...    35   0.11 
gi|41872583 Rho-associated, coiled-coil containing protein kinas...    35   0.11 
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     35   0.11 
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     35   0.15 
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    35   0.15 
gi|56961680 coiled-coil domain containing 147 [Homo sapiens]           35   0.15 
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           35   0.19 
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]    34   0.25 

>gi|19557645 secretogranin III [Homo sapiens]
          Length = 468

 Score =  928 bits (2399), Expect = 0.0
 Identities = 468/468 (100%), Positives = 468/468 (100%)

Query: 1   MGFLGTGTWILVLVLPIQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAEEDKIKKTYPP 60
           MGFLGTGTWILVLVLPIQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAEEDKIKKTYPP
Sbjct: 1   MGFLGTGTWILVLVLPIQAFPKPGGSQDKSLHNRELSAERPLNEQIAEAEEDKIKKTYPP 60

Query: 61  ENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDY 120
           ENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDY
Sbjct: 61  ENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDY 120

Query: 121 DSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGL 180
           DSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGL
Sbjct: 121 DSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGL 180

Query: 181 ITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGL 240
           ITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGL
Sbjct: 181 ITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGL 240

Query: 241 AKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLI 300
           AKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLI
Sbjct: 241 AKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLI 300

Query: 301 TIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSE 360
           TIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSE
Sbjct: 301 TIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSE 360

Query: 361 KSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLK 420
           KSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLK
Sbjct: 361 KSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLK 420

Query: 421 KHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL 468
           KHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL
Sbjct: 421 KHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRIYSSL 468


>gi|110815815 centlein isoform 1 [Homo sapiens]
          Length = 1406

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 75/317 (23%), Positives = 139/317 (43%), Gaps = 23/317 (7%)

Query: 74  NLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDH---K 130
           +L+   + T+ E+++K R++ R   ++N      + S +N +L D ++  K  L      
Sbjct: 515 SLSPKSSFTDSEELQKLRKAERK--IENLEKALQLKSQENDELRDAHEKRKERLQMLQTN 572

Query: 131 FQDDPDGLHQLD-GTPLTA-EDIVHKIAARIYEENDRAVFDKIVS-KLLNLGLITESQAH 187
           ++   + L Q + G+ +T    I      ++ +E+  AV++++   K  N  L+ +    
Sbjct: 573 YRAVKEQLKQWEEGSGMTEIRKIKRADPQQLRQEDSDAVWNELAYFKRENQELMIQKM-- 630

Query: 188 TLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDE 247
            LE+E+ E L+  IS +    +E         E Q  +  E      +  +   K   ++
Sbjct: 631 NLEEELDE-LKVHISIDKAAIQELNRCVAERREEQLFRSGEDDEVKRSTPEKNGKEMLEQ 689

Query: 248 TVSNTLTLTNGL---ERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMK 304
           T+     L N L   E+R++   E N + ++      +LLK    + E +EKE     ++
Sbjct: 690 TLQKVTELENRLKSFEKRSRKLKEGNKKLMKENDFLKSLLKQQQEDTETREKE-----LE 744

Query: 305 TLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHE 364
            +I   K + K  T   E  V   E   E+ +L+ +   E NA  N ++    P EKSH+
Sbjct: 745 QIIKGSKDVEKENT---ELQVKISELETEVTSLR-RQVAEANALRNENEELINPMEKSHQ 800

Query: 365 ETDSTKEEAAKMEKEYG 381
             D  K E A M+   G
Sbjct: 801 SADRAKSEMATMKVRSG 817


>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
          Length = 2039

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 45/183 (24%), Positives = 84/183 (45%), Gaps = 14/183 (7%)

Query: 285 KSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLD-EMIALQTKNKL 343
           K I+ EKE  + +     ++  ++F +   K      +E      N++ E + L+ K+KL
Sbjct: 644 KEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKL 703

Query: 344 EKNATDNISKLFPAPSEKSH--EETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEP 401
           EKN  D+ S      S++ +  EE D  K+E+ K  +E   +KD  ++  + P   TD+ 
Sbjct: 704 EKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFRE-EKIKDLKEERENIP---TDKD 759

Query: 402 KGKTEAYLEAIRKNI-------EWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILD 454
              T   + AI ++I       E   +  +K  KE  +  + R  I ++    +E+   +
Sbjct: 760 SEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFE 819

Query: 455 KEE 457
           KE+
Sbjct: 820 KEK 822



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 86/407 (21%), Positives = 163/407 (40%), Gaps = 52/407 (12%)

Query: 83  EKEKIEK-------ERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDP 135
           EK K +K       E+ + +    D+    E+ D T  +   +     K  L HK ++  
Sbjct: 581 EKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKE 640

Query: 136 DGLHQLDG------TPLTAEDIVHKIAA-RIYEENDRAVFDKIVSKLLNLGLITESQAHT 188
               +++G      T  +A+++   +   R + + +    D+     LN+    E ++ T
Sbjct: 641 KHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNM----EHESLT 696

Query: 189 LEDEVAEVLQKLISKEANNYEEDPNKPTSWTE--NQAGKIPEKVTPMAAIQDGLAKGEND 246
           LE +    L+K I  + +  E+  +K  ++ E  ++  K  EK      I+D   + EN 
Sbjct: 697 LEKK--SKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENI 754

Query: 247 ETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEK------EAKEKETLI 300
            T  ++   + G+    ++               + + K ID EK      E+KEK    
Sbjct: 755 PTDKDSEFTSLGMSAIEESIG------------LHLVEKEIDIEKQEKHIKESKEKPEKR 802

Query: 301 TIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSE 360
           + +K   D  KM  K  T   E+ + + E+  E   L     ++K    +  KL+   +E
Sbjct: 803 SQIKEK-DIEKMERK--TFEKEKKIKH-EHKSEKDKLDLSECVDKIKEKD--KLYSHHTE 856

Query: 361 KSHEETDSTKEEAA---KMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRK--- 414
           K H+E + +K  AA     ++E    K   K D   P  +    + K +  +E   K   
Sbjct: 857 KCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSD 916

Query: 415 NIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAI 461
           N E+ K    K  ++D +L K     +K++        + +E+  +I
Sbjct: 917 NSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 963



 Score = 29.6 bits (65), Expect = 6.1
 Identities = 58/286 (20%), Positives = 109/286 (38%), Gaps = 49/286 (17%)

Query: 31  LHNRELSAERPLNEQIAEAEEDKIKKTYPPENKPGQSN--------YSFVDNLNLL---- 78
           ++ + L  + PL++  +    D +K        P Q+N         +  + L LL    
Sbjct: 221 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKRE 280

Query: 79  -------KAITEKEKIEKERQSIRSSPLDNKLNVE-DVDST--KNRKLIDDYDSTKSGLD 128
                  ++ T+ E    E QS+  S +D  ++ E + DS   ++++++       S LD
Sbjct: 281 VPLSDDDESYTDSE----EAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALD 336

Query: 129 -HKFQDDPDGL--HQLDGTPLTA-----EDIVHKIAARIYEENDRAVFDK-IVSKLLNLG 179
            ++F+DD D      +D   +       E+        ++ + ++A + K   SK     
Sbjct: 337 EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS 396

Query: 180 LITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKP--------TSWTENQAGKIPEKVT 231
            +  S   + ++E  +   K IS   +   E  N           S    Q GK+  K+ 
Sbjct: 397 RVLYSSTESSDEEALQ--NKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLK 454

Query: 232 PMAAIQDGLAKGENDETVSNT----LTLTNGLERRTKTYSEDNFEE 273
                ++     +  E   NT    LT+  GL+   KT  E NF +
Sbjct: 455 NQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRK 500


>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
          Length = 2062

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 45/183 (24%), Positives = 84/183 (45%), Gaps = 14/183 (7%)

Query: 285 KSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLD-EMIALQTKNKL 343
           K I+ EKE  + +     ++  ++F +   K      +E      N++ E + L+ K+KL
Sbjct: 667 KEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNMEHESLTLEKKSKL 726

Query: 344 EKNATDNISKLFPAPSEKSH--EETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEP 401
           EKN  D+ S      S++ +  EE D  K+E+ K  +E   +KD  ++  + P   TD+ 
Sbjct: 727 EKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFRE-EKIKDLKEERENIP---TDKD 782

Query: 402 KGKTEAYLEAIRKNI-------EWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILD 454
              T   + AI ++I       E   +  +K  KE  +  + R  I ++    +E+   +
Sbjct: 783 SEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFE 842

Query: 455 KEE 457
           KE+
Sbjct: 843 KEK 845



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 86/407 (21%), Positives = 163/407 (40%), Gaps = 52/407 (12%)

Query: 83  EKEKIEK-------ERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDP 135
           EK K +K       E+ + +    D+    E+ D T  +   +     K  L HK ++  
Sbjct: 604 EKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKE 663

Query: 136 DGLHQLDG------TPLTAEDIVHKIAA-RIYEENDRAVFDKIVSKLLNLGLITESQAHT 188
               +++G      T  +A+++   +   R + + +    D+     LN+    E ++ T
Sbjct: 664 KHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDETEDLFLNM----EHESLT 719

Query: 189 LEDEVAEVLQKLISKEANNYEEDPNKPTSWTE--NQAGKIPEKVTPMAAIQDGLAKGEND 246
           LE +    L+K I  + +  E+  +K  ++ E  ++  K  EK      I+D   + EN 
Sbjct: 720 LEKK--SKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENI 777

Query: 247 ETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEK------EAKEKETLI 300
            T  ++   + G+    ++               + + K ID EK      E+KEK    
Sbjct: 778 PTDKDSEFTSLGMSAIEESIG------------LHLVEKEIDIEKQEKHIKESKEKPEKR 825

Query: 301 TIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSE 360
           + +K   D  KM  K  T   E+ + + E+  E   L     ++K    +  KL+   +E
Sbjct: 826 SQIKEK-DIEKMERK--TFEKEKKIKH-EHKSEKDKLDLSECVDKIKEKD--KLYSHHTE 879

Query: 361 KSHEETDSTKEEAA---KMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRK--- 414
           K H+E + +K  AA     ++E    K   K D   P  +    + K +  +E   K   
Sbjct: 880 KCHKEGEKSKNTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEKHLMEKKNKQSD 939

Query: 415 NIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAI 461
           N E+ K    K  ++D +L K     +K++        + +E+  +I
Sbjct: 940 NSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSI 986



 Score = 29.6 bits (65), Expect = 6.1
 Identities = 58/286 (20%), Positives = 109/286 (38%), Gaps = 49/286 (17%)

Query: 31  LHNRELSAERPLNEQIAEAEEDKIKKTYPPENKPGQSN--------YSFVDNLNLL---- 78
           ++ + L  + PL++  +    D +K        P Q+N         +  + L LL    
Sbjct: 244 VNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELELLLKRE 303

Query: 79  -------KAITEKEKIEKERQSIRSSPLDNKLNVE-DVDST--KNRKLIDDYDSTKSGLD 128
                  ++ T+ E    E QS+  S +D  ++ E + DS   ++++++       S LD
Sbjct: 304 VPLSDDDESYTDSE----EAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSALD 359

Query: 129 -HKFQDDPDGL--HQLDGTPLTA-----EDIVHKIAARIYEENDRAVFDK-IVSKLLNLG 179
            ++F+DD D      +D   +       E+        ++ + ++A + K   SK     
Sbjct: 360 EYEFKDDDDEEINKMIDDRHILRKEQRKENEPEAEKTHLFAKQEKAFYPKSFKSKKQKPS 419

Query: 180 LITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKP--------TSWTENQAGKIPEKVT 231
            +  S   + ++E  +   K IS   +   E  N           S    Q GK+  K+ 
Sbjct: 420 RVLYSSTESSDEEALQ--NKKISTSCSVIPETSNSDMQTKKEYVVSGEHKQKGKVKRKLK 477

Query: 232 PMAAIQDGLAKGENDETVSNT----LTLTNGLERRTKTYSEDNFEE 273
                ++     +  E   NT    LT+  GL+   KT  E NF +
Sbjct: 478 NQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRK 523


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 74/341 (21%), Positives = 138/341 (40%), Gaps = 32/341 (9%)

Query: 149  EDIVHKIAARIYEENDR-----AVFDKIVSKLLNLGLITES-----QAHTLEDEVAEVLQ 198
            E+I+H++ AR+ EE DR     A   K+  ++L+L    E      Q   LE   AE   
Sbjct: 921  EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980

Query: 199  KLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQD---GLAKGEN-DETVSNTLT 254
            K +  E    ++  NK +   +    +I +  T +A  ++    L K +N  E++ + L 
Sbjct: 981  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040

Query: 255  L--------TNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTL 306
            +           LE+  +    D  +  +   +  A +  +  +   KE+E    + +  
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100

Query: 307  IDFVKMMVKYGTISPEEG-VSYL-ENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHE 364
             +  +       I   EG +S L E+LD   A + K + +K       +      E + +
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 365  ETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDK 424
             T + +E  AK E+E   LK +  ++  +   +  E + K    +E + + +E  K+   
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 425  KGNKEDYDLSKMRDFINKQADAYVEKGILD--KEEAEAIKR 463
              +K    L K      + AD   E  +L   K+E E  K+
Sbjct: 1221 NLDKNKQTLEK------ENADLAGELRVLGQAKQEVEHKKK 1255



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 72/345 (20%), Positives = 137/345 (39%), Gaps = 28/345 (8%)

Query: 48   EAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVED 107
            E EED+ ++      K  Q      + L   +A  +K ++EK     +   L++++ V D
Sbjct: 932  EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991

Query: 108  VDS---TKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARI-YEEN 163
              +   +K RKL+++     S L     ++ +    L       E ++ ++  R+  EE 
Sbjct: 992  DQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1048

Query: 164  DRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQA 223
             R   +K+  KL         Q   L+ ++AE+  +L  K     EE+     +  +++ 
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK-----EEELQAALARLDDEI 1103

Query: 224  GKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYAL 283
             +    +  +  ++  ++  +  E + +     N  E++ +   E+  E L+        
Sbjct: 1104 AQKNNALKKIRELEGHIS--DLQEDLDSERAARNKAEKQKRDLGEE-LEALK--TELEDT 1158

Query: 284  LKSIDSEKEAKEK-ETLITIMKTLID--------FVKMMVKYGTISPEEGVSYLENLDEM 334
            L S  +++E + K E  +T++K  +D         V+ M +    + EE    LE     
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218

Query: 335  IALQTKNK--LEKNATDNISKLFPAPSEKSHEETDSTKEEAAKME 377
             A   KNK  LEK   D   +L      K   E    K EA   E
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 74/341 (21%), Positives = 138/341 (40%), Gaps = 32/341 (9%)

Query: 149  EDIVHKIAARIYEENDR-----AVFDKIVSKLLNLGLITES-----QAHTLEDEVAEVLQ 198
            E+I+H++ AR+ EE DR     A   K+  ++L+L    E      Q   LE   AE   
Sbjct: 928  EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987

Query: 199  KLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQD---GLAKGEN-DETVSNTLT 254
            K +  E    ++  NK +   +    +I +  T +A  ++    L K +N  E++ + L 
Sbjct: 988  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047

Query: 255  L--------TNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTL 306
            +           LE+  +    D  +  +   +  A +  +  +   KE+E    + +  
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107

Query: 307  IDFVKMMVKYGTISPEEG-VSYL-ENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHE 364
             +  +       I   EG +S L E+LD   A + K + +K       +      E + +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 365  ETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDK 424
             T + +E  AK E+E   LK +  ++  +   +  E + K    +E + + +E  K+   
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 425  KGNKEDYDLSKMRDFINKQADAYVEKGILD--KEEAEAIKR 463
              +K    L K      + AD   E  +L   K+E E  K+
Sbjct: 1228 NLDKNKQTLEK------ENADLAGELRVLGQAKQEVEHKKK 1262



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 72/345 (20%), Positives = 137/345 (39%), Gaps = 28/345 (8%)

Query: 48   EAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVED 107
            E EED+ ++      K  Q      + L   +A  +K ++EK     +   L++++ V D
Sbjct: 939  EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998

Query: 108  VDS---TKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARI-YEEN 163
              +   +K RKL+++     S L     ++ +    L       E ++ ++  R+  EE 
Sbjct: 999  DQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055

Query: 164  DRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQA 223
             R   +K+  KL         Q   L+ ++AE+  +L  K     EE+     +  +++ 
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK-----EEELQAALARLDDEI 1110

Query: 224  GKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYAL 283
             +    +  +  ++  ++  +  E + +     N  E++ +   E+  E L+        
Sbjct: 1111 AQKNNALKKIRELEGHIS--DLQEDLDSERAARNKAEKQKRDLGEE-LEALK--TELEDT 1165

Query: 284  LKSIDSEKEAKEK-ETLITIMKTLID--------FVKMMVKYGTISPEEGVSYLENLDEM 334
            L S  +++E + K E  +T++K  +D         V+ M +    + EE    LE     
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225

Query: 335  IALQTKNK--LEKNATDNISKLFPAPSEKSHEETDSTKEEAAKME 377
             A   KNK  LEK   D   +L      K   E    K EA   E
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 74/341 (21%), Positives = 138/341 (40%), Gaps = 32/341 (9%)

Query: 149  EDIVHKIAARIYEENDR-----AVFDKIVSKLLNLGLITES-----QAHTLEDEVAEVLQ 198
            E+I+H++ AR+ EE DR     A   K+  ++L+L    E      Q   LE   AE   
Sbjct: 928  EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987

Query: 199  KLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQD---GLAKGEN-DETVSNTLT 254
            K +  E    ++  NK +   +    +I +  T +A  ++    L K +N  E++ + L 
Sbjct: 988  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047

Query: 255  L--------TNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTL 306
            +           LE+  +    D  +  +   +  A +  +  +   KE+E    + +  
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107

Query: 307  IDFVKMMVKYGTISPEEG-VSYL-ENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHE 364
             +  +       I   EG +S L E+LD   A + K + +K       +      E + +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 365  ETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDK 424
             T + +E  AK E+E   LK +  ++  +   +  E + K    +E + + +E  K+   
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 425  KGNKEDYDLSKMRDFINKQADAYVEKGILD--KEEAEAIKR 463
              +K    L K      + AD   E  +L   K+E E  K+
Sbjct: 1228 NLDKNKQTLEK------ENADLAGELRVLGQAKQEVEHKKK 1262



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 72/345 (20%), Positives = 137/345 (39%), Gaps = 28/345 (8%)

Query: 48   EAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVED 107
            E EED+ ++      K  Q      + L   +A  +K ++EK     +   L++++ V D
Sbjct: 939  EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998

Query: 108  VDS---TKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARI-YEEN 163
              +   +K RKL+++     S L     ++ +    L       E ++ ++  R+  EE 
Sbjct: 999  DQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1055

Query: 164  DRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQA 223
             R   +K+  KL         Q   L+ ++AE+  +L  K     EE+     +  +++ 
Sbjct: 1056 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK-----EEELQAALARLDDEI 1110

Query: 224  GKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYAL 283
             +    +  +  ++  ++  +  E + +     N  E++ +   E+  E L+        
Sbjct: 1111 AQKNNALKKIRELEGHIS--DLQEDLDSERAARNKAEKQKRDLGEE-LEALK--TELEDT 1165

Query: 284  LKSIDSEKEAKEK-ETLITIMKTLID--------FVKMMVKYGTISPEEGVSYLENLDEM 334
            L S  +++E + K E  +T++K  +D         V+ M +    + EE    LE     
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225

Query: 335  IALQTKNK--LEKNATDNISKLFPAPSEKSHEETDSTKEEAAKME 377
             A   KNK  LEK   D   +L      K   E    K EA   E
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1270


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 40.8 bits (94), Expect = 0.003
 Identities = 74/341 (21%), Positives = 138/341 (40%), Gaps = 32/341 (9%)

Query: 149  EDIVHKIAARIYEENDR-----AVFDKIVSKLLNLGLITES-----QAHTLEDEVAEVLQ 198
            E+I+H++ AR+ EE DR     A   K+  ++L+L    E      Q   LE   AE   
Sbjct: 921  EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980

Query: 199  KLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQD---GLAKGEN-DETVSNTLT 254
            K +  E    ++  NK +   +    +I +  T +A  ++    L K +N  E++ + L 
Sbjct: 981  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040

Query: 255  L--------TNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTL 306
            +           LE+  +    D  +  +   +  A +  +  +   KE+E    + +  
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100

Query: 307  IDFVKMMVKYGTISPEEG-VSYL-ENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHE 364
             +  +       I   EG +S L E+LD   A + K + +K       +      E + +
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 365  ETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDK 424
             T + +E  AK E+E   LK +  ++  +   +  E + K    +E + + +E  K+   
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 425  KGNKEDYDLSKMRDFINKQADAYVEKGILD--KEEAEAIKR 463
              +K    L K      + AD   E  +L   K+E E  K+
Sbjct: 1221 NLDKNKQTLEK------ENADLAGELRVLGQAKQEVEHKKK 1255



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 72/345 (20%), Positives = 137/345 (39%), Gaps = 28/345 (8%)

Query: 48   EAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVED 107
            E EED+ ++      K  Q      + L   +A  +K ++EK     +   L++++ V D
Sbjct: 932  EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991

Query: 108  VDS---TKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARI-YEEN 163
              +   +K RKL+++     S L     ++ +    L       E ++ ++  R+  EE 
Sbjct: 992  DQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK 1048

Query: 164  DRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQA 223
             R   +K+  KL         Q   L+ ++AE+  +L  K     EE+     +  +++ 
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK-----EEELQAALARLDDEI 1103

Query: 224  GKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYAL 283
             +    +  +  ++  ++  +  E + +     N  E++ +   E+  E L+        
Sbjct: 1104 AQKNNALKKIRELEGHIS--DLQEDLDSERAARNKAEKQKRDLGEE-LEALK--TELEDT 1158

Query: 284  LKSIDSEKEAKEK-ETLITIMKTLID--------FVKMMVKYGTISPEEGVSYLENLDEM 334
            L S  +++E + K E  +T++K  +D         V+ M +    + EE    LE     
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218

Query: 335  IALQTKNK--LEKNATDNISKLFPAPSEKSHEETDSTKEEAAKME 377
             A   KNK  LEK   D   +L      K   E    K EA   E
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQE 1263


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 90/472 (19%), Positives = 194/472 (41%), Gaps = 58/472 (12%)

Query: 31   LHNRELSAERPLNEQIAEAEEDKIKK------TYPPENKPGQSNYSFV---DNLNLLKAI 81
            ++N++L  E     ++   +ED+IKK      +   EN     +YS     D   + + +
Sbjct: 568  VYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTL 627

Query: 82   TEKEKI----EKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDG 137
             + E +    ++E   +RS  L+ K  ++++ +T  +++ +D    +S L+ K +   D 
Sbjct: 628  FDAETVALDAKRESAFLRSENLELKEKMKEL-ATTYKQMENDIQLYQSQLEAKKKMQVDL 686

Query: 138  LHQLDG--------TPLTAEDIVHKIAARIYEENDRAVFDKIVSK------LLNLGLITE 183
              +L          T L    +   +   +  E       K ++K       L   +I  
Sbjct: 687  EKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILL 746

Query: 184  SQAHTLEDEVAEVLQKLI---SKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGL 240
            S+  +L  EV E L+K I   S+E +    + +K  S   ++  ++   +  +   +D L
Sbjct: 747  SELKSLPSEV-ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL 805

Query: 241  AKGEN-----DETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKE 295
            A  ++     D+   N  TL    E++ K   E+N    Q   N           KEA++
Sbjct: 806  ATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNL---------SKEAQK 856

Query: 296  KETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMI-----ALQTKNKLEKNATDN 350
             ++ +  +KT + +    ++  T   +E ++ +E L E +      LQT  + +   T+ 
Sbjct: 857  FDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEK 916

Query: 351  ISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLE 410
            + +        + E     K++  ++++     +D  K D  +      + + +    LE
Sbjct: 917  LQQTLEEVKTLTQE-----KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALE 971

Query: 411  AIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEK--GILDKEEAEA 460
            +++++ E +     K ++E      M +   +  D + +K  GI  K++ EA
Sbjct: 972  SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA 1023


>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
          Length = 1235

 Score = 39.7 bits (91), Expect = 0.006
 Identities = 92/428 (21%), Positives = 162/428 (37%), Gaps = 45/428 (10%)

Query: 51  EDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDS 110
           E  I+     E +  Q      +N  L+K+   K+ I +    +     + + N++ VDS
Sbjct: 460 ETNIEHNLKSEEEKDQEKQQMFEN-KLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDS 518

Query: 111 TKNRKLIDDYDSTKSGLDHKFQDDP-DGLHQLDGTPLTAEDIVHKI---AARIYEENDRA 166
                L  +    K G D K Q D       + GT   A D+  K+   +A   + ND  
Sbjct: 519 EVG--LTKEDTQEKLGEDDKTQKDVISNTSDVIGT-CEAADVAQKVDEDSAEDTQSNDGK 575

Query: 167 VFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKI 226
              ++  KL+N  ++      T E  + E++      E N  EE  NK       QA   
Sbjct: 576 EVVEVGQKLINKPMVGPEAGGTKEVPIKEIV------EMNEIEEGKNK------EQAINS 623

Query: 227 PEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKS 286
            E +  +   + G  +GE     S+    T  +E R+     D         +   +   
Sbjct: 624 SENIMDINE-EPGTTEGEEITESSS----TEEMEVRSVVADTDQKALGSEVQDASKVTTQ 678

Query: 287 IDSEKE----AKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNK 342
           ID EK+    + +KE  +T++    +   +++    I+ + G    EN +E+ +L     
Sbjct: 679 IDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSG----ENKEEIGSLSKTET 734

Query: 343 LEKNATDNISKLFPAPSEKSHEE-TDSTKEEAA-KMEKEYGSLKDSTKDDNSNPGGKTDE 400
           +    ++N       P E  ++  T ST + ++  +     S    TKD  S    +T  
Sbjct: 735 ILPPESEN-------PKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRR 787

Query: 401 PKGKTEAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEA 460
            K   +   + I   +E      K     D    ++R F+ +Q     E   L KEE  A
Sbjct: 788 QKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELR-FLRRQ--ELRELRFLQKEEQRA 844

Query: 461 IKRIYSSL 468
            +++ S L
Sbjct: 845 QQQLNSKL 852



 Score = 33.9 bits (76), Expect = 0.33
 Identities = 59/280 (21%), Positives = 108/280 (38%), Gaps = 23/280 (8%)

Query: 173 SKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTP 232
           S+LL    +T      + + +AE   ++  +  +  EED  + T         +P   + 
Sbjct: 284 SQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETE------NSLPIPASK 337

Query: 233 MAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSED--NFEELQYFPNFYALLKSIDSE 290
            A+    +A  E D+   N   L +  E+  ++ SED  N + L   P      K+++  
Sbjct: 338 RASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDI 397

Query: 291 KEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTK--NKLEKNAT 348
            E    +  +  M  L D   ++ +    +  E    LENL +    +T   N + +   
Sbjct: 398 NE-HITDAQLEAMTELHDRTAVIKE----NEREKRPKLENLPDTEDQETVDINSVSEGKE 452

Query: 349 DNISKLFPAPSE---KSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKT 405
           +NI        E   KS EE D  K++   M +      +  KD          +  G+ 
Sbjct: 453 NNIMITLETNIEHNLKSEEEKDQEKQQ---MFENKLIKSEEIKDTILQTVDLVSQETGEK 509

Query: 406 EAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQAD 445
           EA ++A+   +   K+  ++   ED    K  D I+  +D
Sbjct: 510 EANIQAVDSEVGLTKEDTQEKLGEDDKTQK--DVISNTSD 547


>gi|226497734 RNA binding motif protein 19 [Homo sapiens]
          Length = 960

 Score = 39.3 bits (90), Expect = 0.008
 Identities = 50/220 (22%), Positives = 85/220 (38%), Gaps = 29/220 (13%)

Query: 211 DPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDN 270
           DP KP +W+++       K  P  +    + K E  + V+  L          K   +  
Sbjct: 82  DPAKPRAWSKHAQKPSQPKQPPKDSTTPEIKKDEKKKKVAGQL---------EKLKEDTE 132

Query: 271 FEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLEN 330
           F+E  +        ++     +  + E      K   D++      G  S EEG    E+
Sbjct: 133 FQE--FLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFDSDSGQESEEEGAG--ED 188

Query: 331 LDEMIALQTKNKLEKNATDN---ISKLFPAPSEKSHEETDSTKE-----EAAKMEKEYGS 382
           L+E  +L+ K  ++K  +D     SK+  A S  S EE +S  E     E ++ E+E  S
Sbjct: 189 LEEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGSEAEEEDSS 248

Query: 383 LKDSTKDDNSN--------PGGKTDEPKGKTEAYLEAIRK 414
                ++ +S         P GK   P+ + E    A +K
Sbjct: 249 ATPVLQERDSKGAGQEQGMPAGKKRPPEARAETEKPANQK 288


>gi|226497654 RNA binding motif protein 19 [Homo sapiens]
          Length = 960

 Score = 39.3 bits (90), Expect = 0.008
 Identities = 50/220 (22%), Positives = 85/220 (38%), Gaps = 29/220 (13%)

Query: 211 DPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDN 270
           DP KP +W+++       K  P  +    + K E  + V+  L          K   +  
Sbjct: 82  DPAKPRAWSKHAQKPSQPKQPPKDSTTPEIKKDEKKKKVAGQL---------EKLKEDTE 132

Query: 271 FEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLEN 330
           F+E  +        ++     +  + E      K   D++      G  S EEG    E+
Sbjct: 133 FQE--FLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFDSDSGQESEEEGAG--ED 188

Query: 331 LDEMIALQTKNKLEKNATDN---ISKLFPAPSEKSHEETDSTKE-----EAAKMEKEYGS 382
           L+E  +L+ K  ++K  +D     SK+  A S  S EE +S  E     E ++ E+E  S
Sbjct: 189 LEEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGSEAEEEDSS 248

Query: 383 LKDSTKDDNSN--------PGGKTDEPKGKTEAYLEAIRK 414
                ++ +S         P GK   P+ + E    A +K
Sbjct: 249 ATPVLQERDSKGAGQEQGMPAGKKRPPEARAETEKPANQK 288


>gi|226497574 RNA binding motif protein 19 [Homo sapiens]
          Length = 960

 Score = 39.3 bits (90), Expect = 0.008
 Identities = 50/220 (22%), Positives = 85/220 (38%), Gaps = 29/220 (13%)

Query: 211 DPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDN 270
           DP KP +W+++       K  P  +    + K E  + V+  L          K   +  
Sbjct: 82  DPAKPRAWSKHAQKPSQPKQPPKDSTTPEIKKDEKKKKVAGQL---------EKLKEDTE 132

Query: 271 FEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLEN 330
           F+E  +        ++     +  + E      K   D++      G  S EEG    E+
Sbjct: 133 FQE--FLSVHQRRAQAATWANDGLDAEPSKGKSKPASDYLNFDSDSGQESEEEGAG--ED 188

Query: 331 LDEMIALQTKNKLEKNATDN---ISKLFPAPSEKSHEETDSTKE-----EAAKMEKEYGS 382
           L+E  +L+ K  ++K  +D     SK+  A S  S EE +S  E     E ++ E+E  S
Sbjct: 189 LEEEASLEPKAAVQKELSDMDYLKSKMVKAGSSSSSEEEESEDEAVHCDEGSEAEEEDSS 248

Query: 383 LKDSTKDDNSN--------PGGKTDEPKGKTEAYLEAIRK 414
                ++ +S         P GK   P+ + E    A +K
Sbjct: 249 ATPVLQERDSKGAGQEQGMPAGKKRPPEARAETEKPANQK 288


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 38.9 bits (89), Expect = 0.010
 Identities = 82/391 (20%), Positives = 167/391 (42%), Gaps = 44/391 (11%)

Query: 47   AEAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIEKE--RQSIRSSPLDNKLN 104
            +E  ++ ++K    + +PG  +++      L +   E ++++K+  R   + S L+  + 
Sbjct: 1984 SEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVK 2043

Query: 105  VEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEEND 164
              +   T+++K   D + TK  L    +       +L    +  +D   + AAR+  +N 
Sbjct: 2044 ALEFVQTESQK---DLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSE-AARVLADNL 2099

Query: 165  RAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAG 224
            +   +   +K        ES    ++ +  ++ ++L   E  + +E  N        +  
Sbjct: 2100 KLKKELQSNK--------ESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRRE 2151

Query: 225  KIPEKVTPMAAIQDGLAKGEND-----ETVSNTLTLTNGLERRTKTYSEDNF----EELQ 275
            K+  + T +  IQ  L K + +     E + +T+T      +   +  +D      E  +
Sbjct: 2152 KVHLEET-IGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKK 2210

Query: 276  YFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEE---GVSYLENLD 332
            +   F   ++S   E+E + KE   +++K   D ++ M    +I  EE    +S LE+ D
Sbjct: 2211 WERKFSDAIQS--KEEEIRLKEDNCSVLK---DQLRQM----SIHMEELKINISRLEH-D 2260

Query: 333  EMI---ALQTKNKLEKNATDNI---SKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDS 386
            + I     QT+ +L++   D +   +K   +  E++     S++ E AK+E E  SLKD 
Sbjct: 2261 KQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQ 2320

Query: 387  TKDDNSNPGGKTDEPKGKTEAYLEAIRKNIE 417
               D SN   K  E KG  E  +     +I+
Sbjct: 2321 L-TDLSNSLEKCKEQKGNLEGIIRQQEADIQ 2350



 Score = 35.8 bits (81), Expect = 0.086
 Identities = 94/459 (20%), Positives = 179/459 (38%), Gaps = 69/459 (15%)

Query: 27   QDKSLHNRELSAERPLNEQIAEAEEDKIKKTYPPENKPGQSNYSFVDNLNLL-----KAI 81
            ++KSL   ELS  R   E++ ++  D ++     +NK   +    +  L LL     K I
Sbjct: 1498 ENKSLQE-ELSLARGTIERLTKSLAD-VESQVSAQNKEKDT---VLGRLALLQEERDKLI 1552

Query: 82   TEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNR--KLIDDYDSTKSGLDHKFQDDPDGLH 139
            TE ++   E QS+ SS    KL +E +   K +  K I+   S+K     ++Q+    L 
Sbjct: 1553 TEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612

Query: 140  Q--------LDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGLITESQAHTLED 191
            +         +     AE I H + A   E+ +  ++ K+ S   N    TE Q    E 
Sbjct: 1613 KEYEILLQSYENVSNEAERIQHVVEAVRQEKQE--LYGKLRSTEAN-KKETEKQLQEAEQ 1669

Query: 192  EVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSN 251
            E+ E+ +K+       + +   +     E +  ++  +V P        AK   +  +S+
Sbjct: 1670 EMEEMKEKM-----RKFAKSKQQKILELEEENDRLRAEVHPAG----DTAKECMETLLSS 1720

Query: 252  TLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVK 311
              ++   LER    Y                  +S+ SEK++  +E  +  +K  I+   
Sbjct: 1721 NASMKEELERVKMEYE-----------TLSKKFQSLMSEKDSLSEE--VQDLKHQIE--- 1764

Query: 312  MMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSEK------SHEE 365
                 G +S +  +   E  D           + N T+  ++  P  +E+      S   
Sbjct: 1765 -----GNVSKQANLEATEKHDN----------QTNVTEEGTQSIPGETEEQDSLSMSTRP 1809

Query: 366  TDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDKK 425
            T S    +AK      S   S+ D+ +N   + D+ K +     E  +KN E+ +  + +
Sbjct: 1810 TCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENE 1869

Query: 426  GNKEDYDLSKMRDFINKQADAYVEKGILDKEEAEAIKRI 464
             N     +S     +    +   +  +L+++  E + R+
Sbjct: 1870 KNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRV 1908


>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
           [Homo sapiens]
          Length = 651

 Score = 38.1 bits (87), Expect = 0.017
 Identities = 105/457 (22%), Positives = 168/457 (36%), Gaps = 75/457 (16%)

Query: 20  FPKP--GGSQDKSLHNRELSAERPLNEQIAEAEEDKIKKT-------------------Y 58
           FPKP   G+ DKS         RPL  QI     DK K                     +
Sbjct: 37  FPKPLQRGTNDKS---------RPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRKILQW 87

Query: 59  PPENKPGQSNYSFVDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLID 118
           PP     +    F  +L   K   +K + +K +     +PL         DS K      
Sbjct: 88  PPIYTAAREQTPF-RHLYTSKTHLKKAEYKKSKDEKGGTPLKK-------DSKKKGGSYA 139

Query: 119 DYDSTKSGLDHKFQDDPDGLHQLDGTPLTA--EDIVHKIAARIYEENDRAVFDKIVSKLL 176
               +K  ++ K +      ++ D TPL +  E+   K +    E N  +   K VSK  
Sbjct: 140 TNPESKQIVEEKTKRQ----NEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNC 195

Query: 177 NLGLITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAI 236
           +            +D+      K  + E  + + +P K    ++     I E  +  +  
Sbjct: 196 SQ-----------KDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLN 244

Query: 237 QDGL--AKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAK 294
            D L      +DE+++    L N  +  +K YS    +  +      A  KS D+E E  
Sbjct: 245 VDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAK-KSSDAESEDS 303

Query: 295 E---KETLITIMKTLIDFVKMMVKYGTISP--EEGVSYLENLDEMIALQTKNKLEKNATD 349
           +   K++         D  K  VK  T S   E G S  E  D     + K KL+K+   
Sbjct: 304 KDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTK---KDKKKLKKDDKK 360

Query: 350 NISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYL 409
             +K +P       E TD+   +A     +  +LK ++K+D+     K       +E+ L
Sbjct: 361 KDTKKYP-------ESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESEL 413

Query: 410 EAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADA 446
           E+  K  +  +K DKK +K D   S   D  +  AD+
Sbjct: 414 ES--KESQKDEKKDKKDSKTDNKKSVKNDEESTDADS 448



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 31/125 (24%), Positives = 53/125 (42%), Gaps = 8/125 (6%)

Query: 339 TKNKLEKNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKT 398
           +KN  +K     I+  F   SE   E  +S K+E    +      K S K+D  +    +
Sbjct: 391 SKNDDKKKDAKKIT--FSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADS 448

Query: 399 DEPKGKTEAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEA 458
            EPKG ++   +  +K  +  KK DKK      D  K  +    ++D  ++K     +E 
Sbjct: 449 -EPKGDSKKGKKDEKKGKKDSKKDDKK-----KDAKKNAESTEMESDLELKKDKKHSKEK 502

Query: 459 EAIKR 463
           +  K+
Sbjct: 503 KGSKK 507


>gi|156104889 myeloid/lymphoid or mixed-lineage leukemia (trithorax
           homolog, Drosophila); translocated to, 3 [Homo sapiens]
          Length = 568

 Score = 37.7 bits (86), Expect = 0.023
 Identities = 53/250 (21%), Positives = 102/250 (40%), Gaps = 40/250 (16%)

Query: 184 SQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIP--------EKVTPMAA 235
           S+ H L  E  E   K  S+E  +  ++P++  + +  ++ K P        EK+ P  A
Sbjct: 194 SKPHKLMKEHKEKPSK-DSREHKSAFKEPSRDHNKSSKESSKKPKENKPLKEEKIVPKMA 252

Query: 236 IQDGLAKGENDETVSNTLTLTNGLERRTKTY------SEDNFEELQYFPNFYALLKSIDS 289
            ++     +  +  SN LT+T+G +++  +       SE+   + +   +  AL KS  S
Sbjct: 253 FKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKKSSSEALFKSFSS 312

Query: 290 -----------EKEAKEKETLITIMKTLIDFVKM-MVKYGTISPEEGVSYLENLDEMIAL 337
                      +K+ K+K             VKM  VK  + + E+  S L   D+++  
Sbjct: 313 APPLILTCSADKKQIKDK-----------SHVKMGKVKIESETSEKKKSTLPPFDDIVD- 360

Query: 338 QTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGS-LKDSTKDDNSNPGG 396
              + +E+N +       P+P+  S   + S      + +    S +KD   DDN     
Sbjct: 361 PNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESD 420

Query: 397 KTDEPKGKTE 406
           + ++    +E
Sbjct: 421 EVEDNDNDSE 430


>gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens]
          Length = 1844

 Score = 37.4 bits (85), Expect = 0.029
 Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 6/126 (4%)

Query: 338  QTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGK 397
            +TK KL +       +  P    K+ E+T+   EE +K     G   DS+KD  +     
Sbjct: 995  ETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLW 1054

Query: 398  TDEPKGKTEAYL----EAIRKNIEWLKKHDKKGNKED-YDLSKMRDFINKQADAYVE-KG 451
            T++ + +T + L     AI+K   WLK   ++   E+  +L   RD  ++     ++ KG
Sbjct: 1055 TEKYQPQTASELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKG 1114

Query: 452  ILDKEE 457
              D EE
Sbjct: 1115 SSDDEE 1120


>gi|197313718 IQ motif containing G [Homo sapiens]
          Length = 443

 Score = 37.4 bits (85), Expect = 0.029
 Identities = 54/250 (21%), Positives = 109/250 (43%), Gaps = 46/250 (18%)

Query: 209 EEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSE 268
           EE PN P        G+   +   M   QD + K    +T+  T TL   ++   + +S+
Sbjct: 125 EEGPNLPEI---RHRGRFAVEFNKM---QDLVFKKPTRQTIMTTETLKK-IQIDRQFFSD 177

Query: 269 ---DNFEELQYFPNFYALLKSIDSE------------KEAKEKETLITIMKTLIDFVKMM 313
              D  +ELQ    + +LL+++  E            +E K ++ +I++ K LI+ VK  
Sbjct: 178 VIADTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEKGRKQIISLQKQLIN-VKKE 236

Query: 314 VKYGTISPEEGVSYLENL-DEMIALQTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEE 372
            ++   S  E   Y+ NL D++  ++ K+ LE       ++L  A ++K    T+     
Sbjct: 237 WQFEVQSQNE---YIANLKDQLQEMKAKSNLENRYMKTNTELQIAQTQKKCNRTEEL--- 290

Query: 373 AAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIE-----WLKKHDKKGN 427
              + +E   L+  T+++             + E +L   ++ +E     W++K+DK   
Sbjct: 291 ---LVEEIEKLRMKTEEE--------ARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDTE 339

Query: 428 KEDYDLSKMR 437
            +  +L+ ++
Sbjct: 340 MKQNELNALK 349


>gi|14165288 IQ motif containing G [Homo sapiens]
          Length = 443

 Score = 37.4 bits (85), Expect = 0.029
 Identities = 54/250 (21%), Positives = 109/250 (43%), Gaps = 46/250 (18%)

Query: 209 EEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSE 268
           EE PN P        G+   +   M   QD + K    +T+  T TL   ++   + +S+
Sbjct: 125 EEGPNLPEI---RHRGRFAVEFNKM---QDLVFKKPTRQTIMTTETLKK-IQIDRQFFSD 177

Query: 269 ---DNFEELQYFPNFYALLKSIDSE------------KEAKEKETLITIMKTLIDFVKMM 313
              D  +ELQ    + +LL+++  E            +E K ++ +I++ K LI+ VK  
Sbjct: 178 VIADTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEKGRKQIISLQKQLIN-VKKE 236

Query: 314 VKYGTISPEEGVSYLENL-DEMIALQTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEE 372
            ++   S  E   Y+ NL D++  ++ K+ LE       ++L  A ++K    T+     
Sbjct: 237 WQFEVQSQNE---YIANLKDQLQEMKAKSNLENRYMKTNTELQIAQTQKKCNRTEEL--- 290

Query: 373 AAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIE-----WLKKHDKKGN 427
              + +E   L+  T+++             + E +L   ++ +E     W++K+DK   
Sbjct: 291 ---LVEEIEKLRMKTEEE--------ARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDTE 339

Query: 428 KEDYDLSKMR 437
            +  +L+ ++
Sbjct: 340 MKQNELNALK 349


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 37.4 bits (85), Expect = 0.029
 Identities = 72/359 (20%), Positives = 143/359 (39%), Gaps = 42/359 (11%)

Query: 77   LLKAITEKEKIEKERQSIRSSPLDNKLNVE--DVDSTKNRKLIDDYDSTKSGLDHKFQDD 134
            ++K  T+ E +EKE Q +R   +D    +E  D++  + +K I     TK  +  K  + 
Sbjct: 1235 VIKYKTDPE-MEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTK--EV 1291

Query: 135  PDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGLITESQAHTLEDEVA 194
               + Q    P T E++   + A++ EE  + V       L       E Q    E+E++
Sbjct: 1292 VQEILQFQEDPQTKEEVA-SLRAKLSEEQKKQV------DLERERASQEEQIARKEEELS 1344

Query: 195  EVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLT 254
             V ++++ +E   YEE+P          A  I  ++  +  ++  L + +   T      
Sbjct: 1345 RVKERVVQQEVVRYEEEPGLRAE-ASAFAESIDVELRQIDKLRAELRRLQRRRTELERQL 1403

Query: 255  LTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMV 314
                 ER+ +  +E   + LQ       L      E EA+EK T            K+++
Sbjct: 1404 EELERERQARREAEREVQRLQ-----QRLAALEQEEAEAREKVT---------HTQKVVL 1449

Query: 315  KYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPSEKSHEE----TDSTK 370
            +       E       L+E    Q + +L +   + + +   A  +   +E    ++S +
Sbjct: 1450 QQDPQQAREHALLRLQLEEE---QHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQ 1506

Query: 371  EEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDKKGNKE 429
             E    E+E   LK S ++++ +        K + +  +  +   +  L+ H+ K +KE
Sbjct: 1507 VEKGDTEQEIQRLKSSLEEESRS--------KRELDVEVSRLEARLSELEFHNSKSSKE 1557


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score = 36.6 bits (83), Expect = 0.050
 Identities = 85/403 (21%), Positives = 171/403 (42%), Gaps = 40/403 (9%)

Query: 43   NEQIAEAEE-DKIKKT-YPPENK----PGQSNYSFVDNLNLLKAITEKEK-IEKERQSIR 95
            NEQ A A E +K++++ Y  ++K      Q  +   + +   K + ++ K ++ E Q ++
Sbjct: 659  NEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQ 718

Query: 96   S--SPLDNKLNVEDVDST---KNRKLIDDYDSTKSGLDHKFQDDPD-GLHQLDGTPLTAE 149
            +  S   NK  VE ++     K+ KL    +  ++GL      + +    + + + LT E
Sbjct: 719  TLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKE 778

Query: 150  DIVHKIAARIYEENDRAVFDKIVSKLLNLGLITESQAHTLEDEVAEVLQKLISKEANNYE 209
              V  + A+   +ND+  F  +V +L  +    + +  ++E+ +   L K+ +KE     
Sbjct: 779  --VQDLKAK---QNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQL 833

Query: 210  EDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGENDETVSNTLTLTNGLERRTKTYSED 269
               +K         GK  E++  M A+ +     E ++ ++NT      L+   ++    
Sbjct: 834  SITSKVQELQNLLKGK-EEQMNTMKAVLE-----EKEKDLANTGKWLQDLQEENESLKAH 887

Query: 270  NFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLE 329
              E  Q+       LK   S  + +E E ++   +  +  ++ M+K       E  S L 
Sbjct: 888  VQEVAQHN------LKEASSASQFEELEIVLKEKENELKRLEAMLK-------ERESDLS 934

Query: 330  NLDEMIA-LQTKNKLEKNATDNISK--LFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDS 386
            +  +++  +Q +NKL K+  + + +     A S   HEE      E  K      +  DS
Sbjct: 935  SKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDS 994

Query: 387  TKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDKKGNKE 429
             KD   +   K ++ + K    +EA+    + L+    K +KE
Sbjct: 995  LKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE 1037


>gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo
           sapiens]
          Length = 1094

 Score = 35.4 bits (80), Expect = 0.11
 Identities = 26/123 (21%), Positives = 57/123 (46%), Gaps = 8/123 (6%)

Query: 345 KNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTD----- 399
           K   +N +K F + SE+  + +DS+ +  ++   E G   +S ++ +SN     D     
Sbjct: 665 KAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQ 724

Query: 400 EPKGKTEAYLE---AIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKE 456
           + +   E+ LE     ++N +   K D +  +++ + SK  D  N ++ +  +     + 
Sbjct: 725 DSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSES 784

Query: 457 EAE 459
           E+E
Sbjct: 785 ESE 787


>gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo
           sapiens]
          Length = 1150

 Score = 35.4 bits (80), Expect = 0.11
 Identities = 25/71 (35%), Positives = 28/71 (39%), Gaps = 13/71 (18%)

Query: 368 STKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHDKKGN 427
           S  E+  K EK+  S KD  KD       +TDEPK K               K  D K  
Sbjct: 792 SLPEKEDKKEKDKKSKKDERKDKKEERDDETDEPKPKRR-------------KSGDDKDK 838

Query: 428 KEDYDLSKMRD 438
           KED D  K  D
Sbjct: 839 KEDRDERKKED 849


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
           [Homo sapiens]
          Length = 1388

 Score = 35.4 bits (80), Expect = 0.11
 Identities = 41/211 (19%), Positives = 80/211 (37%), Gaps = 9/211 (4%)

Query: 236 IQDGLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDS--EKEA 293
           + D  +  E D   S     +  ++++  T  E    E+Q         KS+++  EK A
Sbjct: 422 LSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTA 481

Query: 294 KEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISK 353
           KE E  IT+ K++   ++ + +   +   +   Y    D       K  LE +      +
Sbjct: 482 KELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADH--EADKKRNLENDVNSLKDQ 539

Query: 354 LFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIR 413
           L        + +  + K    + + +  +    T+ D +    KT     K    LE+  
Sbjct: 540 LEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNN 599

Query: 414 KNIEWLKKHDKKGNKEDYDLSKMRDFINKQA 444
           ++++     DK    E   L   ++FIN Q+
Sbjct: 600 RDLQ-----DKNCLLETAKLKLEKEFINLQS 625


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 35.4 bits (80), Expect = 0.11
 Identities = 91/444 (20%), Positives = 174/444 (39%), Gaps = 62/444 (13%)

Query: 33   NRELSAERPLNEQIAE----AEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAITEKEKIE 88
            N+ L     L EQ+ E    AEEDK +K     +K   ++  F      LK+  EK    
Sbjct: 1144 NKSLKENTFLQEQLVELKMLAEEDK-RKVSELTSKLKTTDEEFQS----LKSSHEKSNKS 1198

Query: 89   KERQSIRSSPLDNKLNVE-DVDSTKNRKLID-------DYDSTK-----SGLDHKFQDDP 135
             E +S+    L  +L ++ D+   K   L++       +  S+K     S + H      
Sbjct: 1199 LEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTT 1258

Query: 136  DGLHQLDGTPLTAEDIVHKIAARIYEENDRAV-FDKIVSKLLNLGLITESQAHTLEDEVA 194
                 L     T  ++  ++     E+N   + F +   +L       +S    +E  V 
Sbjct: 1259 KVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVT 1318

Query: 195  EVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGEND-ETVSNTL 253
            E  ++ + KE  N ++  ++  S       ++ E +  +  +++ L + + +  ++S  L
Sbjct: 1319 E--KEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL 1376

Query: 254  TLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKTLIDFVK-M 312
            T  N   + + + SE             +L K  D EK              L+D V+ +
Sbjct: 1377 TDLNVQLQNSISLSEKEAA-------ISSLRKQYDEEK------------CELLDQVQDL 1417

Query: 313  MVKYGTISPEEGVSYLENLDEMI--------ALQTKNKLEKNATDNISKLFPAPSEKSHE 364
              K  T+S E+ +S LE +D+            Q++    +N    +       S++++E
Sbjct: 1418 SFKVDTLSKEK-ISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYE 1476

Query: 365  ETDST---KEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKK 421
            + +     KEE  +  K +  LK   +DD S    K ++ +   E  L++    I  L+ 
Sbjct: 1477 KDEQINLLKEELDQQNKRFDCLKGEMEDDKS----KMEKKESNLETELKSQTARIMELED 1532

Query: 422  HDKKGNKEDYDLSKMRDFINKQAD 445
            H  +   E   L+++    N+Q D
Sbjct: 1533 HITQKTIEIESLNEVLKNYNQQKD 1556



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 77/407 (18%), Positives = 152/407 (37%), Gaps = 56/407 (13%)

Query: 77  LLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSG----LDHKFQ 132
           L KA++  +K E+ R+ +++   +    +E     +   L  +    K      +    +
Sbjct: 416 LEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSE 475

Query: 133 DDPDGLHQLDGTPLTA--EDIVHKIAARI--YEENDRAVFDKIVSKLLNLGLITESQAHT 188
           +    L +L    L    +++  K+  R   ++E  +   +K  S+ L +    E Q  +
Sbjct: 476 EQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQ-ES 534

Query: 189 LEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMA----------AIQD 238
           L  E  E+ +K I  E+ N   D  +       +  ++   +              A+  
Sbjct: 535 LALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHL 594

Query: 239 GLAKGENDETVSNTLTLTNGLERRTKTYSEDNF--EELQYFPNFYALLKSIDSEKEAKEK 296
              K ++++ ++  +   +  E  +  + +D    E+LQ     Y        EK  +EK
Sbjct: 595 EAEKNKHNKEIT-VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEK 653

Query: 297 ETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFP 356
           ETL+   + +                   +++E ++E    +T  KL+   T+       
Sbjct: 654 ETLLKDKEIIFQ-----------------AHIEEMNE----KTLEKLDVKQTE------- 685

Query: 357 APSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNI 416
              E    E     +   K+E+E   LKD T         K DE K   +  +++I K  
Sbjct: 686 --LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEH 743

Query: 417 EWLKKHDKKGNKEDYD----LSKMRDFINKQADAYVEKGILDKEEAE 459
           E   +  +K  K+  +    L K RD   K+  A+VE    D + +E
Sbjct: 744 EVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSE 790


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 35.0 bits (79), Expect = 0.15
 Identities = 98/488 (20%), Positives = 193/488 (39%), Gaps = 53/488 (10%)

Query: 24   GGSQDKSLHNRELSAE-RPLNEQIAEAEEDKIKKTYPPENKPGQSNYSFVDNLNLLKAIT 82
            G S D S    EL A+   L  Q+A+ EE+        E +  Q N +      L   I+
Sbjct: 1055 GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQIS 1114

Query: 83   E-KEKIEKERQSIRSSPLDNKLNVEDVDSTKNRKLIDDYDSTKSGLDHKFQDDPDGLHQL 141
            E +E +E ER S   +    +   E++++ K  +L D  DST +  + + + + + ++ L
Sbjct: 1115 ELQEDLESERASRNKAEKQKRDLGEELEALKT-ELEDTLDSTAAQQELRSKREQE-VNIL 1172

Query: 142  DGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGLI---TESQAHTLEDEVAEVLQ 198
              T L  E   H+   +   +      +++  +L     +    E    TLE+E  E+  
Sbjct: 1173 KKT-LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231

Query: 199  --KLISKEANNYEEDPNKPTSWT----------ENQAGKIPEKVTPMAAIQDGL------ 240
              K++ +   + E    K  +            E    ++ +KVT +    D +      
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291

Query: 241  AKGENDETVSNTLTLTNGLERRTKTYSEDNFEEL-------QYFPNFYALLKSIDSEKEA 293
            +  ++ +   +   L + L+   +   E+N ++L       Q      +  + ++ E+EA
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA 1351

Query: 294  KE--KETLITIMKTLIDFVKMMV-KYGTISPEEGVSY-----LENL----DEMIAL---- 337
            K   ++ + T+   + D  K M    G +   E V       LE L    +E +A     
Sbjct: 1352 KHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL 1411

Query: 338  -QTKNKLEKNATDNISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGG 396
             +TK +L++   D +  L        + E    K +    E++  S K + + D +    
Sbjct: 1412 EKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEA 1471

Query: 397  KTDEPKGKT--EAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILD 454
            +  E K  +   A  EA+ +  E L++ +K+   E  DL   +D + K      +     
Sbjct: 1472 REKETKALSLARALEEAMEQKAE-LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRAL 1530

Query: 455  KEEAEAIK 462
            +++ E +K
Sbjct: 1531 EQQVEEMK 1538



 Score = 32.7 bits (73), Expect = 0.72
 Identities = 59/300 (19%), Positives = 114/300 (38%), Gaps = 30/300 (10%)

Query: 149  EDIVHKIAARIYEENDRAVFDKIVSKLLNLGLITESQAHTLEDEVAE---VLQKLIS--- 202
            E+I H + AR+ EE +R    +   K +    I E +    E+E A     L+K+ +   
Sbjct: 914  EEICHDLEARVEEEEERCQHLQAEKKKMQQN-IQELEEQLEEEESARQKLQLEKVTTEAK 972

Query: 203  ----KEANNYEEDPN----KPTSWTENQAGKIPEKVTPMAAIQDGLAKGEN--------- 245
                +E     ED N    K     E++  +    +T        LAK +N         
Sbjct: 973  LKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDL 1032

Query: 246  DETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKETLITIMKT 305
            +E +         LE+  +    D+ +         A +  +  +   KE+E    + + 
Sbjct: 1033 EERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARV 1092

Query: 306  LIDFVKMMVKYGTISPEEGVSYLENLDEMIALQ--TKNKLEKNATDNISKL--FPAPSEK 361
              +  +  +    I   E  S +  L E +  +  ++NK EK   D   +L       E 
Sbjct: 1093 EEEAAQKNMALKKIRELE--SQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150

Query: 362  SHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKK 421
            + + T + +E  +K E+E   LK + +++      +  E + K    +E + + +E  K+
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 35.0 bits (79), Expect = 0.15
 Identities = 25/95 (26%), Positives = 45/95 (47%), Gaps = 3/95 (3%)

Query: 364  EETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIEWLKKHD 423
            E+ D+ +    K+EKE   LK  T DD S+      + KG  E    ++   +  LK  +
Sbjct: 1208 EQIDNLQRVKQKLEKEKSELKMET-DDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKE 1266

Query: 424  KKGNKEDYDLSKMRDFINKQADAYVEKGILDKEEA 458
            ++  +   DL+  R  +  +A  Y  +  LD+++A
Sbjct: 1267 EEQQRLINDLTAQRARLQTEAGEYSRQ--LDEKDA 1299



 Score = 33.1 bits (74), Expect = 0.55
 Identities = 75/408 (18%), Positives = 166/408 (40%), Gaps = 42/408 (10%)

Query: 72   VDNLNLLKAITEKEKIEKERQSIRSSPLDNKLNVEDVDSTKN--RKLIDDYDSTKSGLDH 129
            +DNL  +K     +K+EKE+  ++    D   N E +   K    K+    +   S L  
Sbjct: 1210 IDNLQRVK-----QKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264

Query: 130  KFQDDPDGLHQLDGTPLTAEDIVHKIAARIYEENDRAVFDKIVSKLLNLGLITESQAHTL 189
            K ++    ++ L       +    + + ++ +E D  V     SK  +   I E + H L
Sbjct: 1265 KEEEQQRLINDLTAQRARLQTEAGEYSRQL-DEKDALVSQLSRSKQASTQQIEELK-HQL 1322

Query: 190  EDEVAEVLQKLISKEANNYEEDPNKPTSWTENQAGKIPEKVTPMAAIQDGLAKGEND--- 246
            E+E         + +++ ++ D  +   + E Q GK        A +Q  L+K  ++   
Sbjct: 1323 EEETKAKNALAHALQSSRHDCDLLR-EQYEEEQEGK--------AELQRALSKANSEVAQ 1373

Query: 247  ---ETVSNTLTLTNGLERRTKTYSEDNFEELQYFPNFYALLKSIDSEKEAKEKET---LI 300
               +  ++ +  T  LE   K  ++   E  ++     A   S++  K+  + E    ++
Sbjct: 1374 WRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLML 1433

Query: 301  TIMKT---LIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPA 357
             + ++        K    +  +  E    Y E   E+ A Q +++        +  ++  
Sbjct: 1434 DVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVY-- 1491

Query: 358  PSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLEAIRKNIE 417
              E+S ++ ++ + E   +++E   L +   +     GGK      K +  +E  +  I+
Sbjct: 1492 --EESLDQLETLRRENKNLQQEISDLTEQIAE-----GGKQIHELEKIKKQVEQEKCEIQ 1544

Query: 418  -WLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDK-EEAEAIKR 463
              L++ +     E+  + +++  +N Q  + V++ I +K EE + +KR
Sbjct: 1545 AALEEAEASLEHEEGKILRIQLELN-QVKSEVDRKIAEKDEEIDQLKR 1591


>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
          Length = 872

 Score = 35.0 bits (79), Expect = 0.15
 Identities = 37/186 (19%), Positives = 84/186 (45%), Gaps = 20/186 (10%)

Query: 285 KSIDS--EKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNK 342
           K +DS  +KE K KET++ + + +++  K+      +    G+S  ++ +    L+ K +
Sbjct: 104 KMVDSAYDKEQKAKETILALKEEIVNLTKL------VEQGSGLSMDQHSNIRDLLRFKEE 157

Query: 343 LEKNATDNISKLFP-----APSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGK 397
           + K     +S++       A + +  +ET+ +KEEA     ++            N   +
Sbjct: 158 VTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQF----QQEIQQRQNEASR 213

Query: 398 TDEPKGKTEAYLEAIRKNIEWLKKHDKKGNKEDYDLSKMRDFINKQADAYVEKGILDKEE 457
               K K E  L+ I+ +++  +   K    + Y + K ++ + K      E+ IL++  
Sbjct: 214 EFRKKEKLEKELKQIQADMDSRQTEIKA--LQQY-VQKSKEELQKLEQQLKEQKILNERA 270

Query: 458 AEAIKR 463
           A+ +++
Sbjct: 271 AKELEQ 276


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 34.7 bits (78), Expect = 0.19
 Identities = 52/244 (21%), Positives = 92/244 (37%), Gaps = 27/244 (11%)

Query: 181  ITESQAHTLEDEVAEVLQKLISKEANNYEEDPNKPTSWTENQ--AGKIPEKVTPMAAIQD 238
            + ES+    +DE +E++ +    E ++  E P  PT+ T  +   GK+ E        + 
Sbjct: 1611 VAESKGDEADDERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQE------VTKS 1664

Query: 239  GLAKGENDETVSNTLTLTNGLERRTKTYSEDNFEELQ--------YFPNFYALLKSIDSE 290
                 E  E      +LT+ L+ R + +S     E           F +    L    +E
Sbjct: 1665 SRRNSEGSELSCTEGSLTSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNE 1724

Query: 291  KEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDN 350
            KEA     +  +MK      K       ++P  G S  +       +  + KL   A   
Sbjct: 1725 KEAPSLTKVFDVMK------KGKSTGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAP-- 1776

Query: 351  ISKLFPAPSEKSHEETDSTKEEAAKMEKEYGSLKDSTKDDNSNPGGKTDEPKGKTEAYLE 410
               +F   + K + ET   K ++ +     G  +D+T+    N   K  E  G+ E+ L 
Sbjct: 1777 ADDMFGVGNHKVNAET--AKRKSIRRRHTLGGHRDATEISVLN-FWKVHEQSGERESELS 1833

Query: 411  AIRK 414
            A+ +
Sbjct: 1834 AVNR 1837


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score = 34.3 bits (77), Expect = 0.25
 Identities = 36/154 (23%), Positives = 67/154 (43%), Gaps = 13/154 (8%)

Query: 242  KGENDETVSNTLTLTNGLERRTKTYSEDNF--EELQYFPNFYALLKSIDSEKEAKEKETL 299
            K  N++T      L   +E  ++T S+     E+ + F   +  LK +  +KE +++   
Sbjct: 865  KNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAE 924

Query: 300  ITIMKTLIDFVKMMVKYGTISPEEGVSYLENLDEMIALQTKNKLEKNATDNISKLFPAPS 359
            + ++K        + K  ++   + +S ++ L+E I    K   EK    N  KL    +
Sbjct: 925  LILLKD------SLAKSPSVK-NDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKA 977

Query: 360  EK----SHEETDSTKEEAAKMEKEYGSLKDSTKD 389
            +K    S +ET + KEE   +  E   L  S +D
Sbjct: 978  KKELDSSRKETQTVKEELESLRSEKDQLSASMRD 1011


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.128    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,143,309
Number of Sequences: 37866
Number of extensions: 875691
Number of successful extensions: 2858
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 2677
Number of HSP's gapped (non-prelim): 340
length of query: 468
length of database: 18,247,518
effective HSP length: 106
effective length of query: 362
effective length of database: 14,233,722
effective search space: 5152607364
effective search space used: 5152607364
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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