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Search of human proteins with 194595509
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
(2477 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 4865 0.0
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 4850 0.0
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 2684 0.0
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 637 0.0
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 609 e-173
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 609 e-173
gi|67782321 spectrin beta isoform a [Homo sapiens] 568 e-161
gi|67782319 spectrin beta isoform b [Homo sapiens] 568 e-161
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 558 e-158
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 433 e-121
gi|12025678 actinin, alpha 4 [Homo sapiens] 290 2e-77
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 288 4e-77
gi|4501893 actinin, alpha 2 [Homo sapiens] 280 1e-74
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 280 1e-74
gi|221316624 dystonin isoform 4 [Homo sapiens] 278 5e-74
gi|221316622 dystonin isoform 3 [Homo sapiens] 278 5e-74
gi|221316618 dystonin isoform 2 [Homo sapiens] 278 5e-74
gi|34577047 dystonin isoform 1 [Homo sapiens] 278 5e-74
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 278 5e-74
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 277 1e-73
gi|4557241 actinin, alpha 3 [Homo sapiens] 260 1e-68
gi|33188443 microfilament and actin filament cross-linker protei... 258 7e-68
gi|33188445 microfilament and actin filament cross-linker protei... 258 7e-68
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [... 203 1e-51
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 186 2e-46
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens] 186 2e-46
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens] 186 2e-46
gi|5032285 dystrophin Dp427l isoform [Homo sapiens] 186 2e-46
gi|5032283 dystrophin Dp427m isoform [Homo sapiens] 186 2e-46
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof... 170 1e-41
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 4865 bits (12618), Expect = 0.0
Identities = 2477/2477 (100%), Positives = 2477/2477 (100%)
Query: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
Sbjct: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
Query: 61 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
Sbjct: 61 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
Query: 121 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180
RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
Sbjct: 121 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180
Query: 181 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240
LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
Sbjct: 181 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240
Query: 241 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
Sbjct: 241 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
Query: 301 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
Sbjct: 301 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
Query: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
Sbjct: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
Query: 421 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
Sbjct: 421 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
Query: 481 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
Sbjct: 481 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
Sbjct: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
Query: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
Sbjct: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
Query: 961 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY 1020
APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
Sbjct: 961 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY 1020
Query: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
Sbjct: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
Query: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140
EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
Sbjct: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140
Query: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200
KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
Sbjct: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200
Query: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 1260
TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
Sbjct: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 1260
Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA 1320
YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
Sbjct: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA 1320
Query: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380
WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
Sbjct: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380
Query: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM 1440
HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
Sbjct: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM 1440
Query: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500
LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
Sbjct: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500
Query: 1501 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560
IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
Sbjct: 1501 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560
Query: 1561 DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS 1620
DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS
Sbjct: 1561 DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS 1620
Query: 1621 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1680
LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS
Sbjct: 1621 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1680
Query: 1681 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1740
EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV
Sbjct: 1681 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1740
Query: 1741 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800
KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD
Sbjct: 1741 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800
Query: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1860
LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL
Sbjct: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1860
Query: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1920
KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF
Sbjct: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1920
Query: 1921 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN 1980
ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN
Sbjct: 1921 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN 1980
Query: 1981 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2040
SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN
Sbjct: 1981 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2040
Query: 2041 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT
Sbjct: 2041 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
Query: 2101 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR 2160
FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR
Sbjct: 2101 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR 2160
Query: 2161 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN 2220
QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN
Sbjct: 2161 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN 2220
Query: 2221 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA 2280
AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA
Sbjct: 2221 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA 2280
Query: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF 2340
LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF
Sbjct: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF 2340
Query: 2341 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM 2400
DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM
Sbjct: 2341 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM 2400
Query: 2401 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE 2460
ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE
Sbjct: 2401 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE 2460
Query: 2461 LPTAFDYVEFTRSLFVN 2477
LPTAFDYVEFTRSLFVN
Sbjct: 2461 LPTAFDYVEFTRSLFVN 2477
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 4850 bits (12581), Expect = 0.0
Identities = 2472/2477 (99%), Positives = 2472/2477 (99%), Gaps = 5/2477 (0%)
Query: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
Sbjct: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
Query: 61 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
Sbjct: 61 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
Query: 121 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180
RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
Sbjct: 121 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180
Query: 181 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240
LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
Sbjct: 181 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240
Query: 241 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
Sbjct: 241 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
Query: 301 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
Sbjct: 301 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
Query: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
Sbjct: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
Query: 421 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
Sbjct: 421 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
Query: 481 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
Sbjct: 481 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
Sbjct: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
Sbjct: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
Query: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
Sbjct: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
Sbjct: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
Query: 961 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY 1020
APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
Sbjct: 961 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY 1020
Query: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
Sbjct: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
Query: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140
EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
Sbjct: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140
Query: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200
KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
Sbjct: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200
Query: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 1260
TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
Sbjct: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 1260
Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA 1320
YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
Sbjct: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA 1320
Query: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380
WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
Sbjct: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380
Query: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM 1440
HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
Sbjct: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM 1440
Query: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500
LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
Sbjct: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500
Query: 1501 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560
IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
Sbjct: 1501 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560
Query: 1561 DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS 1620
DEIEAWISEKLQTASDESYKDPTNIQ SKHQKHQAFEAELHANADRIRGVIDMGNS
Sbjct: 1561 DEIEAWISEKLQTASDESYKDPTNIQ-----SKHQKHQAFEAELHANADRIRGVIDMGNS 1615
Query: 1621 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1680
LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS
Sbjct: 1616 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1675
Query: 1681 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1740
EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV
Sbjct: 1676 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1735
Query: 1741 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800
KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD
Sbjct: 1736 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1795
Query: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1860
LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL
Sbjct: 1796 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1855
Query: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1920
KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF
Sbjct: 1856 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1915
Query: 1921 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN 1980
ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN
Sbjct: 1916 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN 1975
Query: 1981 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2040
SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN
Sbjct: 1976 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2035
Query: 2041 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT
Sbjct: 2036 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2095
Query: 2101 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR 2160
FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR
Sbjct: 2096 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR 2155
Query: 2161 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN 2220
QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN
Sbjct: 2156 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN 2215
Query: 2221 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA 2280
AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA
Sbjct: 2216 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA 2275
Query: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF 2340
LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF
Sbjct: 2276 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF 2335
Query: 2341 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM 2400
DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM
Sbjct: 2336 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM 2395
Query: 2401 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE 2460
ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE
Sbjct: 2396 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE 2455
Query: 2461 LPTAFDYVEFTRSLFVN 2477
LPTAFDYVEFTRSLFVN
Sbjct: 2456 LPTAFDYVEFTRSLFVN 2472
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 2684 bits (6958), Expect = 0.0
Identities = 1371/2482 (55%), Positives = 1793/2482 (72%), Gaps = 77/2482 (3%)
Query: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
++ SG KVLETAE+IQERRQ+VL RY FKE R QKLEDSY Q F+RDA++L KWI
Sbjct: 10 VESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWI 69
Query: 61 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
EK+ I +D++Y+DPTN+QGK QKHQ+ EAEVQ S + +L++T + GH A E
Sbjct: 70 MEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET 129
Query: 121 RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180
+ + EL W+LLLE EKG +LL+A K QY++EC D+++WI DKEAI TS ELG+D
Sbjct: 130 KAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGED 189
Query: 181 LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240
E EVL KKFE+FQ ++ A E RV EVNQ+A + +E HP+ LI++KQ+EVNAAW+RL
Sbjct: 190 WERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERL 249
Query: 241 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
+GLALQRQ L AA +QRF RDV E I WIKEKE ++ S+D+G+DL + + L H+GL
Sbjct: 250 RGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGL 309
Query: 301 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
ER+LA + DKVK LCA+A++L SHP A QIQ +E+L+++WE IR LA R+ +L +
Sbjct: 310 ERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT 369
Query: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
Y RF +DF +L+ W+ E A INADEL +DVAG E LLDRHQ+HK EID+++D F+SA
Sbjct: 370 YWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSA 429
Query: 421 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
DE+GQ L+ A H ASDEVREK+ +L ALLELW+ R +QYEQC+D LFYRD+EQVD
Sbjct: 430 DETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVD 489
Query: 481 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
+WMS+QEAFL NEDLG+SL S EALL+KHEDFE++ +AQEEKI +D+ ATKLI ++HY
Sbjct: 490 SWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYD 549
Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
E++ RD LL+RR+AL E+A RR L +S LQ+ + DSD+LK+W+N+K K A DE
Sbjct: 550 SENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDED 609
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
YKD NL+ +VQK Q FE EL+ N+++++ ++K GQ++I+ HYA D V R++EV SLW
Sbjct: 610 YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669
Query: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
++LLEAT+ KG +L EANQQ QF N ED++ WL +VE + S+DYGK L VQN +KH
Sbjct: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
Query: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
LLE+ VAA QD++D +T A F++ GH D+++I+ +QE+LV R+EALKEP+ RK+KL
Sbjct: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
Query: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
D L LQ + RD EDEE WI+E EP A ST GKDLI + LL +H+ + IA HEPRI
Sbjct: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
+ +T++GN MVEEGHFAAEDV +++ LNQ E+L+A+A++R+ DLE ++Q QQY AD +
Sbjct: 850 QEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLH 909
Query: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC-RQQ 959
EAE+W+REKEPIV +T+YG DE++A ALLKKHEA + DL+++G S++ALR QA +C +QQ
Sbjct: 910 EAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQ 969
Query: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
AP + G++ V+ALYD+Q +SPREVTMKKGD+LTLL+S NKDWWKVE D QG VPA
Sbjct: 970 AAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAV 1029
Query: 1020 YVKKLDPAQ-SASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE 1078
YV++L + + EE G+I RQEQI+NQ Y SLL+
Sbjct: 1030 YVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQ--------------------YRSLLD 1069
Query: 1079 LGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK 1138
E+R+ L + +F+L EA ++ +WI EK+A E G +L+ V LQKKFD+FQK
Sbjct: 1070 RAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKA----ENTGVELDDVWELQKKFDEFQK 1125
Query: 1139 DLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLM 1198
DL NE RL+DINKVA+DL EGL+ E ++Q
Sbjct: 1126 DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQ-------------------------- 1159
Query: 1199 VHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNT 1258
ELN RW SLQ+LA+E+ QLLGSAH V+ FHR+AD+TKE IE+K QAL+
Sbjct: 1160 -----------ELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSA 1208
Query: 1259 DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
+ G DL SVQALQR+HEGFERDL LGDKV LGETAERL +SHP++ EDLQ + ELN
Sbjct: 1209 ADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELN 1268
Query: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
+AW L R RK L ++ FLS RDL +WI+ I G+VSS ELA+D+TG E LL
Sbjct: 1269 EAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILL 1328
Query: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438
ERHQEHR +++A A TFQA E F +L+ GH+ASPEI++KL + ER DLEKAW +R+
Sbjct: 1329 ERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRK 1388
Query: 1439 MMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQE 1498
+LDQCLELQ+F +C+Q E+WM ARE L ++DK SLDS+EAL+KK +D DKAI QE
Sbjct: 1389 KILDQCLELQMFQGNCDQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQE 1447
Query: 1499 EKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSR 1558
KI L+ FA+ LIA HYAK +I++R VLDRW+ LKAQ+I++R+KLG+ L+QF R
Sbjct: 1448 GKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYR 1507
Query: 1559 DVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMG 1618
D++E+E WISE L TA DESYKD TNIQ K+ KHQ F E+ ++++ GVI++G
Sbjct: 1508 DLEELEEWISEMLPTACDESYKDATNIQ-----RKYLKHQTFAHEVDGRSEQVHGVINLG 1562
Query: 1619 NSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFW 1678
NSLIE AC G+E+A+K +L L + W L++++ +K +KL EA++QQ FNT I+DF+FW
Sbjct: 1563 NSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFW 1622
Query: 1679 LSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTS 1738
LSE E LLA +D +DLAS NLLKKHQLLE ++ A ED LKDLN+ A+ L++S F+
Sbjct: 1623 LSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVD 1682
Query: 1739 QVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG 1798
Q+ K+D +N RF ++ +AA+ KL E++ L QFF+D+DDEESWI+EK + V S+DYG
Sbjct: 1683 QIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYG 1742
Query: 1799 RDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWK 1858
RDL GVQNL KKHKRLE EL AHEPAIQ VLD +KL D +G+EEIQ RLAQFVEHW+
Sbjct: 1743 RDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWE 1802
Query: 1859 ELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHE 1918
+LK+LA ARG +LEESLEY QF+ N EEEEAWINEK L D GDTLAA Q LL KHE
Sbjct: 1803 KLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHE 1862
Query: 1919 AFETDFTVHKDRVNDVCTNGQDLIKK---NNHHEENISSKMKGLNGKVSDLEKAAAQRKA 1975
A E DF VH+ RV +VC G+D++ K + ISSK++ LN K L KA A K
Sbjct: 1863 ALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKL 1922
Query: 1976 KLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQ 2035
+L+++ AF +FNWKADVVE+WI +KE SLKT+ G DL TLL KQ+T DA LQ+FQQ
Sbjct: 1923 QLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQ 1982
Query: 2036 EGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVE 2095
E + IT LKD+L++A+H QSKAIE R+A+L+KRW QLL SA ++KLLE Q +K E
Sbjct: 1983 ERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042
Query: 2096 DLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQL 2155
DLF+ FA KASA N+W E EE+L++PV C SL EI+ L++ H+ F +SL+ AQADF L
Sbjct: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCL 2102
Query: 2156 AELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEF 2215
ELD+QIK+ V S+PYTW T+E LE TW++L II+ERE ELQKE+ RQ +N ++ QEF
Sbjct: 2103 LELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEF 2162
Query: 2216 AQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGA 2275
Q+A+ F QWI ETR Y LDGS +++E+GTLESQLEA KRK +EI+AM+ QL KI DLG
Sbjct: 2163 EQNASTFLQWILETRAYFLDGS-LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGD 2221
Query: 2276 AMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSM 2335
+E+ALILD KY ST+GLAQQWDQL QLG+RMQHNLEQQIQA++ GV+EE LKEFS
Sbjct: 2222 NLEDALILDIKY---STIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFST 2278
Query: 2336 MFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQE 2395
++KHFD++ +GRL H+EF+SCLR L Y LPMVEE E +P+FE LD VDP R G+VSL++
Sbjct: 2279 IYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLED 2338
Query: 2396 YMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVD 2455
Y AF+I +E+EN+KSS+EIE+AF+AL +EGK Y+TKE++ Q LT EQ +C +HM+ Y+D
Sbjct: 2339 YTAFLIDKESENIKSSDEIENAFQAL-AEGKSYITKEDMKQALTPEQVSFCATHMQQYMD 2397
Query: 2456 GKGRELPTAFDYVEFTRSLFVN 2477
+GR + +DYV FT S F N
Sbjct: 2398 PRGRSHLSGYDYVGFTNSYFGN 2419
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 637 bits (1644), Expect = 0.0
Identities = 544/2269 (23%), Positives = 999/2269 (44%), Gaps = 109/2269 (4%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDENYKDPTNLQGKLQKHQAF 88
K L R+Q L++ Q F R+ + + + D +D LQ+H+ F
Sbjct: 1159 KVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREF 1218
Query: 89 EAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA 148
+ L G ++ H A+ T+R +L + QW L + ++ +LL +
Sbjct: 1219 GRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLAS 1278
Query: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEV 208
+L ++ ++ ++M W+ +K + E G ++ L K+ E ++++ A V +
Sbjct: 1279 LQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHVEAL 1337
Query: 209 NQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETI 268
Q +L+ + +E I+T+ + + W+ L +R +L A + ++ R + +
Sbjct: 1338 QQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAK 1397
Query: 269 SWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP-L 327
+++ E + S + G+DL S Q L ++H+ LE + L K+ AL + A + S L
Sbjct: 1398 EQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAIL 1457
Query: 328 SATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINAD 387
TQ ++R EL+ IR L +L S L +F SWV E +
Sbjct: 1458 EETQKHLRRLELLQGHLAIRGL------QLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
Query: 388 ELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSE 447
+ GA++L +H+E + E+ AH+ + SG++L A+GH + + E+ L
Sbjct: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571
Query: 448 ERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLK 507
A L E R Q +Q + Q ++ D +++ W+ ++ + + D G + L+
Sbjct: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631
Query: 508 KHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRA 567
KH+ ++ L+ + LD+ A L + V R L + AL E A R
Sbjct: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDR 1689
Query: 568 QLADSFHLQQFFRDSDELKSWVNEKMKTAT--DEAYKDPSNLQGKVQKHQAFEAELSANQ 625
+L + L +F R++++L+ W+ + + A + +DP + K F+ ++
Sbjct: 1690 ELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749
Query: 626 SRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNR 685
R+ A + L++ H A V R ++ + W +L E T+ +G LR+ + +R
Sbjct: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809
Query: 686 NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745
++ ++ + E L ++ +DL ++ + H LE ++ + ++ + A + Q
Sbjct: 1810 DLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ 1868
Query: 746 D-AGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI-REK 803
A ++++Q+A+ + L+ M R+ +L + L + V D +W R +
Sbjct: 1869 KLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVR 1928
Query: 804 EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA 863
+ + + + G L HQ L+AE+ E + TQ G + ++V+
Sbjct: 1929 QDLQVEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987
Query: 864 KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDED 923
+L L + + + +++++ L+ Q Q + + E + +E + ++ G +
Sbjct: 1988 ELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVE 2047
Query: 924 SAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSP 983
E L++KHE + L+A ALRE+ ++ R+ L + L +
Sbjct: 2048 EVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRP------RVRDRLPILLQ--RRMRV 2099
Query: 984 REVTMKKGDIL---------TLLNSTNKDWWKVEVNDRQGFVPAAYVK-KLDP-----AQ 1028
+E+ +G L T + +DW + + VP ++ KL P A
Sbjct: 2100 KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAF 2159
Query: 1029 SASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLE 1088
A + E S+A + E + Q+ AG VS R++ + + + L + R LE
Sbjct: 2160 EAEVQAHEEVMTSVAKKGEALLAQSH--PRAGEVSQRLQGLRKHWEDLRQAMALRGQELE 2217
Query: 1089 KSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRL 1147
+ F+ F + +L + WI EKE + ++G DLE L+++ +F+ + +
Sbjct: 2218 DR-RNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGD 2276
Query: 1148 KDINKVAE-DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFN 1206
I +++ L+ + EEV+ + Q+
Sbjct: 2277 ACIRSISDLSLQLKNRDPEEVKIICQRR-------------------------------- 2304
Query: 1207 SIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA 1266
+LN RW S Q L A E+ R+ D + I+EK + + G DL
Sbjct: 2305 --SQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLE 2362
Query: 1267 SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGK 1326
SVQ L RKHE ER++ + +V SL RL Q PE+A L+ + E+ ++W L
Sbjct: 2363 SVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRS 2422
Query: 1327 RADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRT 1386
RA +R+ L H Q+ + ++L+ +R + + + A +LE HQE +
Sbjct: 2423 RAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKA 2482
Query: 1387 EIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLE 1446
E+D+ + GQQLL GH S +I+Q L L+QE + LE AW + ++ L Q LE
Sbjct: 2483 ELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALE 2542
Query: 1447 LQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQA 1506
LQLF E+ E W+ ++E L +E D L +E L+ KH+ + + VQ KI+AL+A
Sbjct: 2543 LQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEA 2602
Query: 1507 FADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566
A L GH R +L R L Q +R +L E + LQ F +D E+ AW
Sbjct: 2603 TARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
Query: 1567 ISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626
+ EK A +E D + L ++ QK Q F+AEL A+ + + + G L++ G
Sbjct: 2663 LREKNLVALEEGLLD-----TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717
Query: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686
A +A++ RL L W L S +K KL++A + +++ + WL +E L
Sbjct: 2718 PA--SEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVEL 2775
Query: 1687 ASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDT 1746
+ G+ L V LL + LEA + + + L QA + + V+++
Sbjct: 2776 RAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARR 2835
Query: 1747 INGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQN 1806
+ RF+ ++ RR L L +FFRD D+E +W++EK L ++DYG+ L+ V++
Sbjct: 2836 LLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRH 2895
Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAA 1866
L+++H+ LE+E+++HE + VL TG KL E+ R+ Q + L+ AA
Sbjct: 2896 LQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAAR 2955
Query: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTV 1926
R L+++ E QQF+ + E +W+ E+ ++ SED G + A Q LL++ EA + D
Sbjct: 2956 RRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015
Query: 1927 HKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
R+ + L + N + ++++ + ++L + A R L E Q
Sbjct: 3016 FSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
Query: 1987 NWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKD 2046
+ ++++W+ K + ++ DYG+DL V+ L K + F +Q+ Q + + L
Sbjct: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
Query: 2047 QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKAS 2106
L + I+A+ + + W +L AR + L A +F + A+
Sbjct: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE--------VHSFQQAAA 3187
Query: 2107 AFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFR 2166
+ + +SL ++ L++ H L + + + +L Q ++ R
Sbjct: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARL-----QTEACR 3242
Query: 2167 VAS-NPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW 2225
+ +P + ++E W LQ +ER L + + F W
Sbjct: 3243 LGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ--------GHAFLGRCQELLAW 3294
Query: 2226 IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
QE R L + E+ E L + QEIR R Q + + G
Sbjct: 3295 AQE-RQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342
Score = 570 bits (1468), Expect = e-162
Identities = 398/1429 (27%), Positives = 700/1429 (48%), Gaps = 80/1429 (5%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74
+++R +L R R KEL+ R L S F + A + E WIQ Q +
Sbjct: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEP--VP 2142
Query: 75 PTNLQGKLQ---KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
P +L+ KL+ KHQAFEAEVQA+ + + + G ++++ H + + RL L + W
Sbjct: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW 2202
Query: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
E L + M +G +L + +++L+ + WI +KE + +LGQDLEH L+++
Sbjct: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262
Query: 192 EEFQTDMAAH---EERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
EF+ + A + + ++ + +L E ++I ++ ++N W G L+ Q
Sbjct: 2263 REFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322
Query: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
+L GA E+ +R++D I+EKE L+ + D G+DL SVQ LLRKHE LER++ ++
Sbjct: 2323 QQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQ 2382
Query: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
+V++L E RL Q P +A ++ +++E+ +W Q+R+ A +R L+ ++ Q+ A
Sbjct: 2383 AQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
Query: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
++L ++A ++ A +L+ HQE K E+D+ DS A +GQ LL
Sbjct: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
Query: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
AGH S ++R+ L L +E ++L W+ + Q +Q ++LQLF E+++ W+ +E
Sbjct: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
Query: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
L +E L D L +E LL KH+ E L Q KI+AL+ A L Q H + R
Sbjct: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRC 2622
Query: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
A+L R+ AL +A RR +L + LQ F +DS E+ +W+ EK A +E D + L
Sbjct: 2623 QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLP 2682
Query: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668
++QK Q F+AEL A+ + L++ GQ+L+ H A + + R+ E+ +LW +L + ++
Sbjct: 2683 AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQ 2742
Query: 669 LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728
K KL++A + + R++E++E WL +E L + G+ L V L LEA V
Sbjct: 2743 KKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVD 2802
Query: 729 AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
+ + + QA+ F GH A++++++ L+ R+++L+EP+ R+ L L +
Sbjct: 2803 KKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLK 2862
Query: 789 LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGN 848
FRD ++E W++EK P+AA+ + G+ L V++L ++HQ L++E++ HE + V G
Sbjct: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922
Query: 849 AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
+V+ GHFAA +V A++ +L + L+A+A++RR L+ + +AQQ+ + EA SW+ E
Sbjct: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982
Query: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETG 968
+ ++ S D G ++ +ALL++ EA DL A+ I+ L++ A + P +
Sbjct: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVL 3042
Query: 969 KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQ 1028
+L + E R +G L ++ + + D AA + D Q
Sbjct: 3043 AQLQAVREAHAELLRR--AEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQ 3100
Query: 1029 SASRENLLEEQGSIALRQEQIDNQTRI--------TKEAGS------VSLRMKQVEELYH 1074
+LEE+ ++ Q Q ++ T E G+ + + ++E +
Sbjct: 3101 DLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWE 3160
Query: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFD 1134
L + + R L + + + A ELQ + EK A + E+ G L V LQ++
Sbjct: 3161 RLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHR 3220
Query: 1135 DFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKS 1194
+++L+A M +EV +Q + +
Sbjct: 3221 RLERELEA--------------------MEKEVARLQTE--------------------A 3240
Query: 1195 ARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQ 1254
RL A + ++ E W +LQ A+ER Q L A + F E W +E+ +
Sbjct: 3241 CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300
Query: 1255 ALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAE----- 1308
+++ D+A + L +HE +++ + L + ++L+ SH SAE
Sbjct: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360
Query: 1309 -DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
+L+ + EL +AW+ R + +S LQ+ +W+ GL+ +
Sbjct: 3361 QELEGRLQELEEAWA-------LRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDY 3413
Query: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFE--QFGQQLLAHGHYASP 1414
V+ E LL RHQ+ + A+ F + + Q+LL P
Sbjct: 3414 GHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKP 3462
Score = 548 bits (1413), Expect = e-155
Identities = 463/1937 (23%), Positives = 876/1937 (45%), Gaps = 91/1937 (4%)
Query: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
A+ I E+ Q++ + + R Q L+ + FQ + D ELE W++EK + S +
Sbjct: 1559 AQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRD 1618
Query: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Y +D + KHQA + E+ ++ +LD+T + G E R L Q
Sbjct: 1619 YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--GPEVPEQQRVVQERLREQ 1676
Query: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWI-NDKEAIVTSEELGQDLEHVEVLQK 189
L E + +L +L ++LRE ED+ W+ + K+A E LG+D EH L
Sbjct: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
Query: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
KF +FQ + +RV A L++ H +++ +Q ++ AW L L R
Sbjct: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
L R +RD+ E ++ ++EK + ++ RDL ++A LR H+GLER+L E
Sbjct: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTER 1855
Query: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITN-WEQIRTLAAERHARLNDSYRLQRFLA 368
+++ L A R+Q+ P +R++ +T W ++ +R A+L + L RF
Sbjct: 1856 QLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
Query: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
RD SW ++ + +E + + + L HQ + E++A E ++ A + GQ L
Sbjct: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQAL 1975
Query: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
A + EV+E+L L ++R + + W ++++ + QLF R+ +++ ++ QE
Sbjct: 1976 LAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEV 2035
Query: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
L LG S++ VE L++KHE F K L+AQ++K AL E L + V R
Sbjct: 2036 SLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPR------VRDRL 2089
Query: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
LL RR + E A R L S + F + + + + W+ + + P +L+
Sbjct: 2090 PILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV--PPGDLR 2147
Query: 609 GKVQ---KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLE 665
K++ KHQAFEAE+ A++ + ++ K G+ L+ +H EV+ R+ + W+ L +
Sbjct: 2148 DKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQ 2207
Query: 666 ATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEA 725
A L+G +L + +F + V+ E W+ E E + D G+DL + L+++
Sbjct: 2208 AMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRG 2267
Query: 726 DVAAH---QDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
+ A I I+ + Q ++ + + I +++ L R+ + ++ +Q+L
Sbjct: 2268 NSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEG 2327
Query: 783 SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
+L + L R++++ I+EKE + + + GKDL VQ LL+KH+ L+ E+ + ++++
Sbjct: 2328 ALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVES 2387
Query: 843 VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
+ ++ + + AA ++ + E+ + W L+++A +RR+ L+ QAQ+ A E
Sbjct: 2388 LEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL 2447
Query: 903 ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP 962
+ + ++ + A +L++H+ ++L ++ SI R Q P
Sbjct: 2448 LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHP 2507
Query: 963 TDDE-----TGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQG-- 1014
+ G E L+ + + + + ++ L+S K + W D
Sbjct: 2508 FSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE 2567
Query: 1015 --FVPAAYVKKLDPAQSASRENLLEEQGSI-ALRQEQIDNQTRITKEAGSVSLRMKQVEE 1071
+ P A ++ L +L + G I AL EA S R + +
Sbjct: 2568 GLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLL 2627
Query: 1072 LYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQK 1131
+L R+ LE+ + +++ E+ W+ EK + EE D + +
Sbjct: 2628 RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKN-LVALEEGLLDTAMLPAQLQ 2686
Query: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191
K +FQ +L A+ + +++ + + L G A E A+Q++
Sbjct: 2687 KQQNFQAELDASMHQQQELQREGQRLLQGGHPASE--AIQER------------------ 2726
Query: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251
++EL W LQ ++++ L A E R R +E + W+E
Sbjct: 2727 ----------------LEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770
Query: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK----VNSLGETAERLIQSHPESA 1307
L G L V L G +R+L A DK +L A+ ++ A
Sbjct: 2771 IEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQAQAFVREGHCLA 2826
Query: 1308 EDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
+D++E+ L Q + SL + +R+ L L +F D + M+W+ L ++ +
Sbjct: 2827 QDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDY 2886
Query: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQER 1427
+ ++ L E+HQ +E+ + + G +L+ GH+A+ E+ ++ L++
Sbjct: 2887 GQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAM 2946
Query: 1428 ADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487
A L +RR++L Q E Q F + +A +W+A R L++ED G S ++ +AL+++
Sbjct: 2947 AHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRL 3006
Query: 1488 EDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL 1547
E + + +I LQ A L + + + ++ V + L + + L
Sbjct: 3007 EATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGL 3066
Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHAN 1607
E L Q R+ ++AW++ K TA + Y +++ K+L +K AF E+ +
Sbjct: 3067 QEQLQLHQLERETLLLDAWLTTKAATAESQDYGQ--DLEGVKVL--EEKFDAFRKEVQSL 3122
Query: 1608 ADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQN 1667
+ +ERGA ++A+ + + W+ L Q +++ L A++ +
Sbjct: 3123 GQAKVYALRKLAGTLERGA-PRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHS 3181
Query: 1668 FNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA- 1726
F + + E AL+ ED G L+SV L ++H+ LE ++ A E + L ++A
Sbjct: 3182 FQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEAC 3241
Query: 1727 --DSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESW 1784
L ++ ++V++ T+ + Q+ R L ++ + H F + +W
Sbjct: 3242 RLGQLHPAAPGGLAKVQEAWATLQAKAQE-------RGQWLAQAAQGHAFLGRCQELLAW 3294
Query: 1785 IKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKE 1844
+E++ L SE+ D+ G + L +H+ L E+ Q + G++L D++
Sbjct: 3295 AQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSA 3354
Query: 1845 EIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG 1904
E+ + L + +EL++ A R QR ES Q+ +E+ EAW+ L+ DYG
Sbjct: 3355 EVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYG 3414
Query: 1905 DTLAAIQGLLKKHEAFE 1921
+++ ++ LL +H+ E
Sbjct: 3415 HSVSDVELLLHRHQDLE 3431
Score = 534 bits (1375), Expect = e-151
Identities = 509/2224 (22%), Positives = 951/2224 (42%), Gaps = 143/2224 (6%)
Query: 115 FASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTS 174
F TI L + +E L + + +L +A L + C ++ W+ + ++
Sbjct: 827 FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL-- 884
Query: 175 EELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234
+ + + +EV+Q K+E F T +A + EV+ A +L Q I+ +Q+E++
Sbjct: 885 QRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELS 944
Query: 235 AAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALL 294
W +L+ L ++ +L + EV F ++ T +++ + + G + AL
Sbjct: 945 QRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL- 1003
Query: 295 RKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354
+ ++ LE +V L + ++++ + +Q + E L +Q++ A+R
Sbjct: 1004 ---QLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRA 1060
Query: 355 ARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHE 414
R ++ Q FL + + L W ++A + + E++ DVA A+ LL HQ+ EI +
Sbjct: 1061 RRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQ 1120
Query: 415 DSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYR 474
+ + D Q + A S EV L VL ++ L LWE R+Q ++ ++LQ F R
Sbjct: 1121 ERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR 1180
Query: 475 DTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLI 534
+ + + +A+L ++LG+ + +LL++H +F + LS + AL KL+
Sbjct: 1181 EVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240
Query: 535 QNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK 594
Q+ H A V + ++ ++ L R+ +RR QL S LQ++ +D EL W+ EK
Sbjct: 1241 QSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGL 1300
Query: 595 TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
A E N+ +++H+A E+EL A + ++AL++ G++L+ ++++ R+
Sbjct: 1301 MAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQ 1360
Query: 655 EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714
+ S W+ L +G +L++A QQ+Q R ++D + L ++EG L S + G+DL + Q
Sbjct: 1361 GLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420
Query: 715 NLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMV 774
LQK+H LE++ ++ + A G + I ++ + + R E L+ +
Sbjct: 1421 RLQKRHQQLESESRTLAAKMAALASMAH-----GMAASPAILEETQKHLRRLELLQGHLA 1475
Query: 775 ARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA 834
R +L S+ L Q E +W+ E P + T+ + L G Q+L +KH+ LQ E+
Sbjct: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535
Query: 835 GHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQ 894
H+ +++ V G ++ GH A+ + + EL W L+ R Q L+ ++ QQ
Sbjct: 1536 AHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQ 1595
Query: 895 YFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQ 954
YF D +E E W+ EK P+V S DYG+DE + L+ KH+AL +L+ Y SS++ L + AQ
Sbjct: 1596 YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ 1655
Query: 955 SCRQQVAPTD----DETGKELVLALYDYQEKSPREV--TMKKGDILTLLNSTNKDWWKVE 1008
+ P E +E + AL + RE+ T++ + L E
Sbjct: 1656 TLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLR------------E 1703
Query: 1009 VNDRQGFVPA-AYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQT------RITKEA-- 1059
D QG++ + K + E+ L A Q Q++ + R+ E+
Sbjct: 1704 AEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLL 1763
Query: 1060 -------GSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEA 1112
V R + ++ + L EL + R L + + R+ E+ + EK
Sbjct: 1764 ERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKAT 1823
Query: 1113 ALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQ 1172
+L + V DL +E + +++L E +L+++ + A ++ + + AVQQ
Sbjct: 1824 SLPN-NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ-KLCPGPQAHAVQQ 1881
Query: 1173 QEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA 1232
++ + + + W LQ+ E+R L A
Sbjct: 1882 RQ----------------------------------QAVTQAWAVLQRRMEQRRAQLERA 1907
Query: 1233 HEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAA---LGDKV 1289
+ RF + W Q L + + +S H+ +L A L +
Sbjct: 1908 RLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQA 1967
Query: 1290 NSLGETAERLIQSHP-----ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRF 1344
LG+ A L P E LQ++ ++ Q W+ +++ +L Q F
Sbjct: 1968 TQLGQQA-LLAAGTPTKEVQEELRALQDQRDQVYQTWA-------RKQERLQAEQQEQLF 2019
Query: 1345 LSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQ 1404
L + L + + + L V E L+ +H+ + A+ A + +
Sbjct: 2020 LRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKT 2079
Query: 1405 LLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAA- 1463
L P ++ +L IL Q R +++ R L L + F + QAE+W+ A
Sbjct: 2080 L------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133
Query: 1464 REAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDIS 1523
+ GD D ++ L+ KH+ F+ + EE + ++ + L+A H G++S
Sbjct: 2134 AQQLKEPVPPGDLRDKLKPLL-KHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVS 2192
Query: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEK--LQTASDESYKD 1581
R + W L+ M + +L + + +F + VD EAWI EK D
Sbjct: 2193 QRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDL 2252
Query: 1582 PTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAAL 1641
+QL + L + + + A + A IR + D+ L R + R + L
Sbjct: 2253 EHCLQLRRRLREFRGNSAGDTVGDA---CIRSISDLSLQLKNRD--PEEVKIICQRRSQL 2307
Query: 1642 ADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
++W Q+L+ A + + + + + E EAL+ + D GKDL SV L
Sbjct: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRL 2367
Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
L+KH+ LE ++ + +++ L + L S ++ ++ + + +++S A R
Sbjct: 2368 LRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKR 2427
Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821
R L+ H+ + + + + + + + R + + ++H+ +AEL +
Sbjct: 2428 REALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSW 2487
Query: 1822 EPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFV 1881
+I TG++L +I+Q LA + L+ +L+++LE Q F+
Sbjct: 2488 TDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFL 2547
Query: 1882 ANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDL 1941
++VE+ E W+ K +ASE D LA ++ LL KH+ E D V +++ + + L
Sbjct: 2548 SSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGL 2607
Query: 1942 IKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKE 2001
+ + ++ + + + + L + A R+ +L+E F + V +W+ EK
Sbjct: 2608 HQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK- 2666
Query: 2002 NSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEA 2061
N + ++ D + + L KQ+ F A L A + + +LL H S+AI+
Sbjct: 2667 NLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQ-QELQREGQRLLQGGHPASEAIQE 2725
Query: 2062 RHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTD 2121
R L W +L NS + KL +A R + +W E E +L
Sbjct: 2726 RLEELGALWGELQDNSQKKVAKLQKACEALR--------LRRSMEELENWLEPIEVELRA 2777
Query: 2122 PVRCNSLEEIKAL----REAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTM 2177
P +L + L RE A A+A Q R+
Sbjct: 2778 PTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCL-----------A 2826
Query: 2178 EALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGS 2237
+ +EE R L + K LQ E+R E L +F + A+ W+QE
Sbjct: 2827 QDVEEQARRLLQRFKSLREPLQ-ERRTALEARSLLLKFFRDADEEMAWVQEKLPL----- 2880
Query: 2238 CMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQ 2297
++ G S + + +HQ + + S + + + L+ + H Q
Sbjct: 2881 AAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ 2940
Query: 2298 QWDQ 2301
Q ++
Sbjct: 2941 QLEK 2944
Score = 513 bits (1321), Expect = e-145
Identities = 548/2418 (22%), Positives = 1012/2418 (41%), Gaps = 212/2418 (8%)
Query: 11 TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASD 69
+ E +Q + + + L RR LE + + F R+ EE E W++E Q + +
Sbjct: 571 SVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNA 630
Query: 70 ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
+D + + G LQKH+A EAEV + V L G + + R +
Sbjct: 631 ALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG 690
Query: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
W+LL ++ +G +L A ++QY + + W+ ++ + + GQD E L +
Sbjct: 691 GWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLR 750
Query: 190 K---FEEFQTDMAAHEERVNEVNQFAA--------------------------------- 213
+ E AA R+ E + A+
Sbjct: 751 RHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPG 810
Query: 214 -----KLIQEQHPEEEL----IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDV 264
K+ P+ + I QD ++ ++ L+ LA R+ +L A + F
Sbjct: 811 PGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSC 870
Query: 265 DETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQS 324
E W++++ L+ D V L K+E LA + + + A++L+Q
Sbjct: 871 GELQLWLEKQTVLLQRVQPQADTLEVMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQR 928
Query: 325 HPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALI 384
+P ++TQIQ ++EEL W Q+ L E+ +L S + FL + + ++ +
Sbjct: 929 YPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL 988
Query: 385 NADELASDVAGAEAL-LDRHQEHKGEIDAH--EDSFKSADESGQALLAAGHYASDEVREK 441
A + S AL L + + E H + +E G A S ++ +
Sbjct: 989 EALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYA-------ESQPLQGQ 1041
Query: 442 LTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDS 501
+ L + E R ++ + Q F ++++Q+ W +A L ++++ + S
Sbjct: 1042 VETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVAS 1101
Query: 502 VEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHER 561
+ LL++H+D + + +E++ LD + + + ++V L + L
Sbjct: 1102 AQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVL 1161
Query: 562 AMRRRAQLADSFHLQQFFRDSDELKSW-VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAE 620
+R+ L + LQ+F R+ D + N + D +D +Q+H+ F
Sbjct: 1162 WEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRL 1221
Query: 621 LSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ 680
LS R +AL G+KL+ H A V ++ + + W +L +E + +L + Q
Sbjct: 1222 LSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL 1281
Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
Q++ ++V ++ W+ E +G +A+ + N+ K+H E+++ A + ++ +
Sbjct: 1282 QEWKQDVAELMQWMEE-KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQV 1340
Query: 741 ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI 800
R+ E+I+ + + L +++EAL M R +L + + +QL R ++D + +
Sbjct: 1341 GRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQL 1400
Query: 801 REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAED 860
+ E S+ G+DL Q L K+HQ L++E R A A + G A+
Sbjct: 1401 EQLEGALQSSETGQDLRSSQRLQKRHQQLESE-----SRTLAAKMAALASMAHGMAASPA 1455
Query: 861 VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGK 920
+ + + ++ E L+ + R L+ S++ Q+ +N SW+ E P T Y +
Sbjct: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
Query: 921 DEDSAEALLKKHEALMSDLSAYGSSIQAL-----------REQAQSCRQQVAPTDDETGK 969
+ A++L +KH+ L ++ A+ +Q + QAQ +Q +
Sbjct: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWA- 1574
Query: 970 ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE----VNDRQ-GFVPAAYVKKL 1024
EL A + + VT ++ L+ + + W E V+ R G AA ++ +
Sbjct: 1575 ELERACEARAQCLQQAVTFQQ----YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630
Query: 1025 DPAQSASRE-----NLLEE--QGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077
+ Q+ E + +EE Q + L ++ Q R+ +E ++ E +L
Sbjct: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQE---------RLREQLRALQ 1681
Query: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWI-NEKEAALTSEEVGADLEQVEVLQKKFDDF 1136
EL R LE + + REA +LQ W+ ++K+AA E +G D E L KF F
Sbjct: 1682 ELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKF 1741
Query: 1137 QKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSAR 1196
Q ++ R+ +AE L G A + +QQ+
Sbjct: 1742 QHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD---------------------- 1779
Query: 1197 LMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL 1256
L W L +L + R L R HRD E ++EK +L
Sbjct: 1780 --------------LQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL 1825
Query: 1257 NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCT 1315
+N DL ++A R H+G ER+L ++ L ETA R+ + P A +Q++
Sbjct: 1826 -PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQ 1884
Query: 1316 ELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE 1375
+ QAW+ L +R +QR+A+L + L RF + RD SW +R + +E +++ +
Sbjct: 1885 AVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGP 1944
Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWV 1435
L HQ R E++AR +Q Q GQQ L + E++++L L +R + + W
Sbjct: 1945 LKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWA 2004
Query: 1436 QRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAIN 1495
+++ L + QLF R+C + E +AA+E L T G S++ VE LI+KHE F K +
Sbjct: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064
Query: 1496 VQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQ 1555
Q++K AAL+ L + + R +L R R+K + L S +
Sbjct: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118
Query: 1556 FSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVI 1615
F++ + E WI Q + +L LL KHQAFEAE+ A+ + + V
Sbjct: 2119 FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLL----KHQAFEAEVQAHEEVMTSVA 2174
Query: 1616 DMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675
G +L+ + E V RL L W+ L Q A + Q+L++ F +
Sbjct: 2175 KKGEALLAQSHPRAGE--VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLA 2232
Query: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKD--LNSQADSLMTSS 1733
+ W+ E E + D G+DL L + +L E ++ D + D + S +D +
Sbjct: 2233 EAWIQEKEVKMNVGDLGQDLEHCLQL--RRRLREFRGNSAGDTVGDACIRSISDLSLQLK 2290
Query: 1734 AFDTSQVK---DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKL 1790
D +VK +R +N R+ + +L + +H R++D+ I+EK+
Sbjct: 2291 NRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEA 2350
Query: 1791 LVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRL 1850
L+ + D G+DL VQ L +KH+ LE E+ + ++ + +L + ++ R
Sbjct: 2351 LIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQ 2410
Query: 1851 AQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAI 1910
+ E W +L+ A R + L+ + Q+ A ++E + + +
Sbjct: 2411 QEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA 2470
Query: 1911 QGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAA 1970
+ +L++H+ + + D ++ + GQ L+ + +I + GL ++S LE A
Sbjct: 2471 RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAW 2530
Query: 1971 AQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGL 2030
+ + +L + F + +E W+ KE+SL ++ L+ ++ LL K + + L
Sbjct: 2531 QEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL 2590
Query: 2031 QAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSH 2090
+ Q I+ + A L H ++++ R +++ R L + R+ +L E +
Sbjct: 2591 EV-QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQ- 2648
Query: 2091 FRKVEDLFLTFAKKASAFNSWFEN-----AEEDLTDPVRCNSLEEIKALREAHDAFRSSL 2145
F + + +W EE L D + A + F++ L
Sbjct: 2649 -------LQAFLQDSQEVAAWLREKNLVALEEGLLDTAM------LPAQLQKQQNFQAEL 2695
Query: 2146 SSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEE---TWRNLQKIIKERELELQKEQ 2202
A +Q EL R+ + +P + E LEE W LQ +++ +LQK
Sbjct: 2696 ---DASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC 2752
Query: 2203 RRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA 2262
E +LR+ + N W++ L + T+ L E+
Sbjct: 2753 ----EALRLRRSMEELEN----WLEPIEVEL--------RAPTVGQALPGV----GELLG 2792
Query: 2263 MRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNT 2322
+ +L+ D A EAL+ + LAQ ++ + ++ +L + +Q R T
Sbjct: 2793 TQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRT 2852
Query: 2323 TGVTEEALKEFSMMFKHF 2340
AL+ S++ K F
Sbjct: 2853 ------ALEARSLLLKFF 2864
Score = 474 bits (1219), Expect = e-133
Identities = 448/1918 (23%), Positives = 797/1918 (41%), Gaps = 177/1918 (9%)
Query: 432 HYASDEVREKLTVLSEERAALLELWE--LRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
HY S + + TV LL+L E L + QYEQ + L W+++++
Sbjct: 244 HYCS-RLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLL---------RWIAEKQMQ 293
Query: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549
L D DSL ++ LL F QE+ A + + RR
Sbjct: 294 LEARDFPDSLPAMRQLLAAFTIFR----TQEKPPRLQQRGAAEALLFRLQTALQAQNRRP 349
Query: 550 AL----------------LSRRNALHERAMRRRA-QLADSFHLQQFFRDSDELKSWVNEK 592
L L A +A+++R QL L + F+ L+ +
Sbjct: 350 FLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKD 409
Query: 593 MKTATDEAYKDPSNL---QGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEV 649
+ D+A P++L + VQ+ EA + + R AL + L +++ +V
Sbjct: 410 AEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADV 469
Query: 650 AARMNEVISLWKKLLEATELKGIKLREANQQQQFN--RNVEDIELWLYEVEGHLASDDYG 707
A R EV W++LL+ L+G + + A+ Q + + VE L E++ S G
Sbjct: 470 ARRQEEVTVRWQRLLQ--HLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACG 527
Query: 708 KDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYE 767
+ L V L ++H LLEA V+AH + + Q + + E ++ K L +
Sbjct: 528 QQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQ 587
Query: 768 ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQ 827
+L + AR+ L +L+ + R+ E+EE W++E + G+DL + L+KH+
Sbjct: 588 SLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHK 647
Query: 828 ALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
AL+AE+ H+ + ++G + D + + W+ L+ + R L+
Sbjct: 648 ALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQ 707
Query: 888 DSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQ 947
+L QYFADA EA SW+RE+ + G+D+ +AE LL++H L L A+ + ++
Sbjct: 708 TALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELR 767
Query: 948 ALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGD-ILTLLNSTNKDWWK 1006
L EQ ++ + + L + P E G + D WK
Sbjct: 768 RLEEQGRAASARAS-----------LFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWK 816
Query: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRM 1066
+ +PA DP +L+ Q ++ E + ++ + R+
Sbjct: 817 MA-------LPAEPDPDFDP------NTILQTQDHLSQDYESLRALAQLRR------ARL 857
Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQV 1126
++ L+ GE LQ W+ ++ L + V + +
Sbjct: 858 EEAMALFGFCSSCGE---------------------LQLWLEKQTVLL--QRVQPQADTL 894
Query: 1127 EVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDS 1186
EV+Q K+++F L + +++ AE L + Q +QQE
Sbjct: 895 EVMQLKYENFLTALAVGKGLWAEVSSSAEQLR-QRYPGNSTQIQRQQE------------ 941
Query: 1187 KTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETK 1246
EL++RW L+ L E++ L + EV F ++ T+
Sbjct: 942 -----------------------ELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQ 978
Query: 1247 EWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPES 1306
+ + L G + ALQ ++ L +V+ L ++ +
Sbjct: 979 VQLRDVLLQLEALQPGSSEDTCHALQLA----QKKTLVLERRVHFLQSVVVKVEEPGYAE 1034
Query: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
++ LQ + L + ++ QR + ++ Q FL + + L+ W ++ + S E
Sbjct: 1035 SQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKE 1094
Query: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQE 1426
++ DV A+ LL HQ+ EI Q + Q + A S E+ L +L Q+
Sbjct: 1095 VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQ 1154
Query: 1427 RADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKK 1486
+L+ W QR+ L + LELQ F R+ + A +A+L+ ++ G+ + +L+++
Sbjct: 1155 GQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQ 1214
Query: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546
H +F + ++ + AL+A ++L+ + H A + + + +W RL+ + ++R +
Sbjct: 1215 HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQ 1274
Query: 1547 LGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHA 1606
L S LQ++ +DV E+ W+ EK A+ E NI L ++H+A E+EL A
Sbjct: 1275 LLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNI-----LQTLKRHEAAESELLA 1329
Query: 1607 NADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQ 1666
+ + +G L+ R C G ED ++ RL L +W+ L +K E+ +L++A +Q+
Sbjct: 1330 TRRHVEALQQVGRELLSRRPC-GQED-IQTRLQGLRSKWEALNRKMTERGDELQQAGQQE 1387
Query: 1667 NFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA 1726
++D L ++E L S + G+DL S L K+HQ LE++ ++ L S A
Sbjct: 1388 QLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMA 1447
Query: 1727 DSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIK 1786
+ S A K R R + ++ A R +L S LHQF + E SW+
Sbjct: 1448 HGMAASPAILEETQKHLR-----RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVA 1502
Query: 1787 EKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEI 1846
E Y L G Q+L +KHK L+ E+ AH+ +Q VL +G+ L+ + I
Sbjct: 1503 EHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHI 1562
Query: 1847 QQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDT 1906
++ + HW EL++ AR Q L++++ +QQ+ +V E E W+ EK LV+S DYG
Sbjct: 1563 VEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRD 1622
Query: 1907 LAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDL 1966
AA L+ KH+A + + ++ + ++ Q L ++ + + L ++ L
Sbjct: 1623 EAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRAL 1680
Query: 1967 EKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQET 2025
++ AA R +L+ +F +A+ ++ W+ ++ + K + G D L TK
Sbjct: 1681 QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAK 1740
Query: 2026 FDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLL 2085
F ++ Q +A L + LL H + R L WS+L + AR L
Sbjct: 1741 FQHQVEMGSQR-VAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR 1799
Query: 2086 EAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSL 2145
+ ++ R DL + S N DL ++A +H L
Sbjct: 1800 DTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCG---------LEAQLRSHQGLEREL 1850
Query: 2146 SSAQADFNQLAELDRQIKSFRVASNPY-TWFTMEALEETWRNLQKIIKERELELQKEQRR 2204
+ +L E +++ + +A+ + W LQ+ +++R R
Sbjct: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQR--------RA 1902
Query: 2205 QEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMR 2264
Q E +L F + W R L VEES S HQ +RA
Sbjct: 1903 QLERARLLARFRTAVRDYASWAARVRQDL-----QVEESSQEPSSGPLKLSAHQWLRAEL 1957
Query: 2265 SQLKKIEDLGAAMEEALIL----DNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQ 2318
+K+ + + +L K + L Q DQ+ Q R Q L+ + Q
Sbjct: 1958 EAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
Score = 465 bits (1196), Expect = e-130
Identities = 440/2064 (21%), Positives = 868/2064 (42%), Gaps = 94/2064 (4%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74
I E Q+ L R + +R +L+ S F + W+ E + S +Y +
Sbjct: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515
Query: 75 PTN-LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
N Q +KH+ + EV+A+ G + ++ +G + + GH ++ I + EL W
Sbjct: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575
Query: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
L + L QA QY + ++ W+ +K +V+S + G+D L K +
Sbjct: 1576 LERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA 1635
Query: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
Q ++A + + E++Q A L + PE++ + Q+ + + L+ LA R +L G
Sbjct: 1636 LQEELAIYWSSMEELDQTAQTLTGPEVPEQQ--RVVQERLREQLRALQELAATRDRELEG 1693
Query: 254 AAEVQRFNRDVDETISWI-KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
+ F R+ ++ W+ +K+ + G D L K + + +V
Sbjct: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753
Query: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372
A A+ L + + ++ ++++L T W ++ L R L D+ R D +
Sbjct: 1754 ACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLE 1813
Query: 373 LTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL--LAA 430
+ + V E KA + +A D+ G EA L HQ + E+ E + E+ + L
Sbjct: 1814 VLTQVQE-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCP 1872
Query: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
G A V+++ +++ A L E RR Q E+ L F +W ++ L
Sbjct: 1873 GPQAH-AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDL 1931
Query: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
E+ S L H+ L A+E+ + + + ++V A
Sbjct: 1932 QVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRA 1991
Query: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVN-EKMKTATDEAYKDPSNLQG 609
L +R+ +++ R++ +L Q F R+ L+ + +++ T ++
Sbjct: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQ 2051
Query: 610 KVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATEL 669
++KH+ F L+A + AL + + L + V R+ ++ ++ E E
Sbjct: 2052 LIRKHEVFLKVLTAQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAES 2105
Query: 670 KGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA 729
+G L + F + E W+ L DL + KH EA+V A
Sbjct: 2106 RGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165
Query: 730 HQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQL 789
H++ + + + H A + ++ + L +E L++ M R Q+L D +
Sbjct: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEF 2225
Query: 790 FRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
+ V+ E WI+EKE + G+DL L ++ + + AG + +
Sbjct: 2226 LQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDL 2285
Query: 850 MVEEGHFAAEDVKA---KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
++ + E+VK + +LN +W + + +Q LE +L+ + + +
Sbjct: 2286 SLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRI 2345
Query: 907 REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQAL-REQAQSCRQQVAPTDD 965
+EKE ++ + D GKD +S + LL+KHE L ++ + +++L RE + C++
Sbjct: 2346 QEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHG 2405
Query: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK-KL 1024
++ +A +Q +S + K+ + L L+ K ++ ++ V A ++ ++
Sbjct: 2406 LRHRQQEVAESWWQLRSRAQ---KRREALDALHQAQK----LQAMLQELLVSAQRLRAQM 2458
Query: 1025 D----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLR--------MKQV--- 1069
D P +LEE + + + + G L ++QV
Sbjct: 2459 DTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAG 2518
Query: 1070 -EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128
E+ SL ++ + L+++ + + ++++W+ KE +L SE + L +E
Sbjct: 2519 LEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEP 2578
Query: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
L K + DL+ ++ + A L G ++++
Sbjct: 2579 LLWKHKMLEWDLEVQAGKISALEATARGLHQGG---------------------HPEAQS 2617
Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248
A A L+ R +L + A R L ++Q F +D+ E W
Sbjct: 2618 ALGRCQAMLL---------------RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662
Query: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE 1308
+ EKN + D A + A +K + F+ +L A + L +RL+Q ++E
Sbjct: 2663 LREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASE 2721
Query: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
+QE+ EL W L + ++ AKL + + R +L +W+ I + + +
Sbjct: 2722 AIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVG 2781
Query: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA 1428
+ + G LL +E +D +A +A Q + GH + +++++ L Q
Sbjct: 2782 QALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFK 2841
Query: 1429 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE 1488
L + +RR L+ L F RD ++ W+ + +D G SL +V L ++H+
Sbjct: 2842 SLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQ 2901
Query: 1489 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG 1548
+ + ++ E + +L+ AGH+A ++++R ++ L+A+ +R L
Sbjct: 2902 NLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQ 2961
Query: 1549 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
++Q QQF ++ E +W++E+ E + L ++ +A + +L A +
Sbjct: 2962 QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL----RRLEATKRDLEAFS 3017
Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF 1668
RI + L R + V A+L A+ + L++++ + L+E +
Sbjct: 3018 PRIERLQQTAALLESRKNPESPK--VLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
Query: 1669 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRLKDLNSQAD 1727
D WL+ A S+DYG+DL V L +K ++ S + ++ L A
Sbjct: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
Query: 1728 SLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKE 1787
+L + ++ +R I ++++ +R L +H +H F + + + ++E
Sbjct: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
Query: 1788 KKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ 1847
K L+ ED G L+ V+ L+++H+RLE EL A E + + +L +
Sbjct: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG-- 3253
Query: 1848 QRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTL 1907
LA+ E W L+ A RGQ L ++ + F+ +E AW E+ L +SE+ + +
Sbjct: 3254 --LAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDV 3311
Query: 1908 AAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLE 1967
A + LL +HE + + + D+ GQ L+ ++ ++ ++ L G++ +LE
Sbjct: 3312 AGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELE 3371
Query: 1968 KAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFD 2027
+A A R + E+ + + + E+W+ E L DYG +S V+ LL + + +
Sbjct: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
Query: 2028 AGLQAFQQEGIANI--TALKDQLL 2049
L A Q+E A + T ++ +LL
Sbjct: 3432 K-LLAAQEEKFAQMQKTEMEQELL 3454
Score = 450 bits (1158), Expect = e-126
Identities = 488/2272 (21%), Positives = 923/2272 (40%), Gaps = 180/2272 (7%)
Query: 9 LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIAS 68
LE AE R Q + R + + L TL R+ FQ A E ++++ Q+
Sbjct: 368 LEWAE--AARSQALQQRLLQLQRLETLARR----------FQHKAALRESFLKDAEQVL- 414
Query: 69 DENYKDPTNL---QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125
D+ P +L + +Q+ EA + G L E +++ E + + + R
Sbjct: 415 DQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQE 474
Query: 126 ELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVE 185
E+ +W+ LL+ ++ + ++ Q ++ L+E E + + + S GQ L V
Sbjct: 475 EVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVV 534
Query: 186 VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLAL 245
L ++ + + ++AH V+ + Q A+L E+++ K + Q L L
Sbjct: 535 ELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVR 594
Query: 246 QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
R+ L + F R+ +E +W+KE Q + + GRDL+ + L+KH+ LE ++
Sbjct: 595 ARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV- 653
Query: 306 ALEDKVKALCAEADR----LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY 361
+ +A+C + R L P + + E + W+ ++T R ARL +
Sbjct: 654 ---HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTAL 710
Query: 362 RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSAD 421
+ ++ AD + SW+ E ++ + D A AE LL RH + + A + +
Sbjct: 711 LVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770
Query: 422 ESGQALLAAG---------------------------------------------HYASD 436
E G+A A + +
Sbjct: 771 EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830
Query: 437 EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496
+ + LS++ +L L +LRR + E+ M L F ++ W+ KQ L + +
Sbjct: 831 TILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQ 888
Query: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRN 556
D++E + K+E+F +L+ + + A +L Q + +++ L R
Sbjct: 889 PQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWG 948
Query: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
L + QLA S + F ++ + + + + EA + P + + Q
Sbjct: 949 QLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL--EALQ-PGSSEDTCHALQL 1005
Query: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
+ + + R+ L+ K+ + + + ++ + L K++ E + + E
Sbjct: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE 1065
Query: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736
+Q F + + + LW V+ L S + D+ + Q L ++H L ++ Q+R+
Sbjct: 1066 TQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125
Query: 737 ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796
+ Q++ D++ + L + + LK R+Q L + L LQ+ R+V+
Sbjct: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185
Query: 797 ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856
+ N G+D+ +LL++H+ ++ PR +A+ G +V+ H
Sbjct: 1186 TATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHP 1245
Query: 857 AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
AA V+ +L + +W L+ ++ QRR+ L SLQ Q++ D E WM EK +
Sbjct: 1246 AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHE 1305
Query: 917 DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976
G + + LK+HEA S+L A ++AL++ + + P E + + L
Sbjct: 1306 PSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSR-RPCGQEDIQTRLQGLR 1363
Query: 977 DYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPA-QSASRENL 1035
E R++T ++GD L + +++ Q +++L+ A QS+
Sbjct: 1364 SKWEALNRKMT-ERGDELQQAGQQEQLLRQLQDAKEQ-------LEQLEGALQSSETGQD 1415
Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEK------------- 1082
L + R +Q+++++R + M ++LE +K
Sbjct: 1416 LRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLA 1475
Query: 1083 -RKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLK 1141
R L+ S + +N W+ E + L + L +K + Q ++K
Sbjct: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535
Query: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201
A++ +++ + L + G + Q + +Q
Sbjct: 1536 AHQGQVQRVLSSGRSLAASG--HPQAQHIVEQ---------------------------- 1565
Query: 1202 VATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNY 1261
+EL W L++ E R+Q L A Q++ D E + W+EEK +++ +Y
Sbjct: 1566 ------CQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
Query: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH-PESAEDLQEKCTELNQA 1320
G D A+ L KH+ + +LA + L +TA+ L PE +QE+ E +A
Sbjct: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679
Query: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE-LAKDVTGAEALLE 1379
L A R +L + L FL + DL W+ + E L +D A L
Sbjct: 1680 LQEL---AATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
Query: 1380 RHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRM 1439
+ + + +++ + A + LL GH A P ++Q+ L ++L + R
Sbjct: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
Query: 1440 MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEE 1499
L HRD + + + L D L +EA ++ H+ ++ + E
Sbjct: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARD-LCGLEAQLRSHQGLERELVGTER 1855
Query: 1500 KIAALQAFAD--QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
++ L A Q + G A + R+ V W L+ +M ++R++L ++ L +F
Sbjct: 1856 QLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFR 1914
Query: 1558 RDVDEIEAWISEKLQTAS-DESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVID 1616
V + +W + Q +ES ++P++ L K HQ AEL A +
Sbjct: 1915 TAVRDYASWAARVRQDLQVEESSQEPSSGPL-----KLSAHQWLRAELEAREKLWQQATQ 1969
Query: 1617 MGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFD 1676
+G + E V+ L AL DQ + Q A K ++L+ ++Q F +
Sbjct: 1970 LGQQALLAAGTPTKE--VQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLE 2027
Query: 1677 FWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD 1736
L+ E L + G + V L++KH++ ++A + + L + +L
Sbjct: 2028 EILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLR------ 2081
Query: 1737 TSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSED 1796
+V+D+ + R ++K +A SR L+ S + F + E WI+ +
Sbjct: 2082 RPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV 2141
Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEH 1856
DL KH+ EAE+ AHE + V G+ L + E+ QRL +H
Sbjct: 2142 PPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKH 2201
Query: 1857 WKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKK 1916
W++L+Q A RGQ LE+ + +F+ V+ EAWI EK + D G L L ++
Sbjct: 2202 WEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRR 2261
Query: 1917 HEAFETDFTVHKDRVNDVC---TNGQDLIKKNNHHEE--NISSKMKGLNGKVSDLEKAAA 1971
F + D V D C + L KN EE I + LN + +
Sbjct: 2262 LREFRGNSA--GDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLL 2319
Query: 1972 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 2031
+ + +L+ + + D V I EKE ++ D G+DL SVQ LL K E + +
Sbjct: 2320 RYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVH 2379
Query: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
Q + + ++ +L + + R + + W Q L + A ++++ L+A
Sbjct: 2380 PIQAQ-VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQ-LRSRAQKRREALDALHQA 2437
Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQAD 2151
+K++ + A + + + + LEE + + D++ S+S A++
Sbjct: 2438 QKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARST 2497
Query: 2152 FNQLAELDRQIKSFRVASNPYT---WFTMEALEETWRNLQKIIKERELELQK 2200
QL A +P++ + LE+ +L+ +E +L+LQ+
Sbjct: 2498 GQQLL----------TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539
Score = 422 bits (1086), Expect = e-117
Identities = 401/1847 (21%), Positives = 806/1847 (43%), Gaps = 94/1847 (5%)
Query: 4 SGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK 63
+G +V E +QER ++ L +EL+ R ++LE + R F R+AE+L+ W+ +
Sbjct: 1658 TGPEVPEQQRVVQERLREQL---RALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQ 1714
Query: 64 LQIAS--DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIR 121
Q A + +DP + K F+ +V+ S + ++ GH A +R
Sbjct: 1715 KQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVR 1774
Query: 122 TRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDL 181
R +L W L E + +G L + ++ R+ +V+ + +K A + +DL
Sbjct: 1775 QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEK-ATSLPNNVARDL 1833
Query: 182 EHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE-QHPEEELIKTKQDEVNAAWQRL 240
+E + + + ++ E ++ E+ + A ++ + P+ ++ +Q V AW L
Sbjct: 1834 CGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVL 1893
Query: 241 KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
+ QR+ +L A + RF V + SW Q + ++ ++ +S L H+ L
Sbjct: 1894 QRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWL 1953
Query: 301 ERDLAALEDKVKALCAEADRLQQSHPLSA----TQIQVKREELITNWEQIRTLAAERHAR 356
+L A E L +A +L Q L+A ++Q + L +Q+ A + R
Sbjct: 1954 RAELEAREK----LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQER 2009
Query: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416
L + Q FL + L + + + L S V E L+ +H+ + A +
Sbjct: 2010 LQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK 2069
Query: 417 FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476
+ E + L VR++L +L + R + EL E R + + F +
Sbjct: 2070 EAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAA 2123
Query: 477 EQVDNWMSKQEAFLLNEDL--GDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLI 534
Q ++W+ A L E + GD D ++ LLK H+ FE + A EE +T++ + L+
Sbjct: 2124 TQAEDWIQAW-AQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSVAKKGEALL 2181
Query: 535 QNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK-M 593
+H +V+ R L L + R +L D + +F + D ++W+ EK +
Sbjct: 2182 AQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEV 2241
Query: 594 KTATDEAYKDPSN---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVA 650
K + +D + L+ ++++ + A + + I ++ +L + + +
Sbjct: 2242 KMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIIC 2301
Query: 651 ARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDL 710
R +++ + W +L A + +R ++++ + E E + + D GKDL
Sbjct: 2302 QRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDL 2361
Query: 711 TNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALK 770
+VQ L +KH LE +V Q +++ + + + A ++ +Q+ + + L+
Sbjct: 2362 ESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLR 2421
Query: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG-KDLIGVQNLLKKHQAL 829
R++ L D+L Q + + E ++ T+ + + + +L++HQ
Sbjct: 2422 SRAQKRREAL-DALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQEC 2480
Query: 830 QAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDS 889
+AE+ I G ++ GH + D++ L L Q+ +L+ + + L+ +
Sbjct: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQA 2540
Query: 890 LQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQAL 949
L+ Q + + + E W+ KE + S E LL KH+ L DL I AL
Sbjct: 2541 LELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISAL 2600
Query: 950 REQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDI--LTLLNSTNKDWWKV 1007
A+ Q P + ++ A+ +E R+ ++ + L L + +D +V
Sbjct: 2601 EATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEV 2659
Query: 1008 EVNDRQGFVPAAYVKKLD----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAG--- 1060
R+ + A LD PAQ ++N E + +Q+++ + + + G
Sbjct: 2660 AAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPA 2719
Query: 1061 --SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEE 1118
++ R++++ L+ L + +K+ L+K+C+ L R EL+ W+ E L +
Sbjct: 2720 SEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPT 2779
Query: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGM 1178
VG L V L Q++L+A ++K A ++E L+ + V++
Sbjct: 2780 VGQALPGVGELL----GTQRELEA------AVDKKAR--QAEALLGQAQAFVREGHCLAQ 2827
Query: 1179 MPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRF 1238
++ + L +R++SL++ +ER L + + +F
Sbjct: 2828 DVEEQA------------------------RRLLQRFKSLREPLQERRTALEARSLLLKF 2863
Query: 1239 HRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAER 1298
RDADE W++EK +YG L++V+ LQ +H+ E ++++ + T +
Sbjct: 2864 FRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYK 2923
Query: 1299 LIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGI 1358
L+Q+ +A ++ + +L +A + L A +R+ L + + Q+FL++ + SW+
Sbjct: 2924 LVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAER 2983
Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
++ S+++ +ALL R + + +++A + + +Q L + + SP++
Sbjct: 2984 GHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLA 3043
Query: 1419 KLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLD 1478
+L + + A+L + R L + L+L R+ + W+ + A ++D G L+
Sbjct: 3044 QLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLE 3103
Query: 1479 SVEALIKKHEDFDKAI-NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLK 1537
V+ L +K + F K + ++ + K+ AL+ A L I ++R+ + W RL
Sbjct: 3104 GVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD 3163
Query: 1538 AQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKH 1597
+ + L + + F + E++ + EK E LS + + Q+H
Sbjct: 3164 QAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGED----GGHSLSSVRTLQQQH 3219
Query: 1598 QAFEAELHANADRIRGVIDMGNSLIERGACAGSE--DAVKARLAALADQWQFLVQKSAEK 1655
+ E EL A + + ++ AC + A LA + + W L K+ E+
Sbjct: 3220 RRLERELEAMEKEV--------ARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQER 3271
Query: 1656 SQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAH 1715
Q L +A + F ++ W E + L +SE+ +D+A LL +H+ L +I
Sbjct: 3272 GQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIREC 3331
Query: 1716 EDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFF 1775
+ +DL + L+ +S F +++V + + GR Q+++ A R + ES L +
Sbjct: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391
Query: 1776 RDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1822
+ ++ E+W+ + L+ DYG ++ V+ L +H+ LE LAA E
Sbjct: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQE 3438
Score = 308 bits (790), Expect = 3e-83
Identities = 458/2331 (19%), Positives = 897/2331 (38%), Gaps = 223/2331 (9%)
Query: 145 LLQAQKL----VQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAA 200
LLQ Q+ QY + D++ WI +K+ + + + L + L F F+T
Sbjct: 263 LLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQ--E 320
Query: 201 HEERVNEVNQFAAKLIQEQ-------------HPEEELIKTKQDEVNAAW-QRLKGLALQ 246
R+ + A L + Q H L + Q W + + ALQ
Sbjct: 321 KPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQ 380
Query: 247 RQGKLFGAAE--VQRFNRDVDETISWIKEKEQLMASDDFGR----DLASVQALLRKHEGL 300
++ E +RF S++K+ EQ++ D R LA+V+A +++ L
Sbjct: 381 QRLLQLQRLETLARRFQHKAALRESFLKDAEQVL---DQARAPPASLATVEAAVQRLGML 437
Query: 301 ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
E + E + +AL AD L+Q S + ++EE+ W+++ + ++ D
Sbjct: 438 EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497
Query: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
+ L + + + E++ + +A LL RH + ++ AH
Sbjct: 498 QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557
Query: 421 DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
+ L ++ + + ++ K L++ + +L+ L RR EQ + F R+ E+ +
Sbjct: 558 AQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEE 617
Query: 481 NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
W+ + + N LG L + L+KH+ E + + L L
Sbjct: 618 AWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPT 677
Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
D R +A+ L R + R A+L + + Q+F D+ E SW+ E+ +++ + A
Sbjct: 678 QPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRER-RSSLERA 736
Query: 601 Y--KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQ------KLIDVN---------- 642
+D + + +++H E L A + + LE+ G+ L VN
Sbjct: 737 SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESL 796
Query: 643 -----------------------------HYAKDEVAARMNEVISLWKKLLEATELKGIK 673
+ + + + + ++ L +L+ +
Sbjct: 797 RNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRAR 856
Query: 674 LREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDR 733
L EA F + +++LWL + L D V L+ ++ L +A +
Sbjct: 857 LEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFL--TALAVGKGL 914
Query: 734 IDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDV 793
++ A Q + ++ I+++QE L R+ L+ + +LA S+ + ++
Sbjct: 915 WAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQEC 974
Query: 794 EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
+ +R+ + G ++ Q Q + E R+ + + E
Sbjct: 975 GPTQVQLRDVLLQLEALQPGSS----EDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030
Query: 854 GHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIV 913
G+ ++ ++ ++ L + ++ + +QR + ++ Q + ++ + W + +
Sbjct: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQL 1090
Query: 914 GSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET------ 967
S + D SA+ LL++H+ L+ ++ + +Q L Q+Q P E
Sbjct: 1091 RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRV 1150
Query: 968 ----GKELVLALYDYQEKSPREVTMKK----GDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
G+EL + Q+ + ++K D T + ++ W + D G
Sbjct: 1151 LGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL---DNLGEDVRE 1207
Query: 1020 YVKKLDPAQSASRENLLEEQG--SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077
+ L + R LL G + ALR A +V +++ ++ + L
Sbjct: 1208 ALSLLQQHREFGR--LLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQ 1265
Query: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQ 1137
E+R+ L S + ++ EL QW+ EK E GA ++ L++
Sbjct: 1266 GRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH----- 1320
Query: 1138 KDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARL 1197
+A ES L + E L+ G +E+ P + D +T
Sbjct: 1321 ---EAAESELLATRRHVEALQQVG-----------RELLSRRPCGQEDIQT--------- 1357
Query: 1198 MVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALN 1257
++ L +W +L + ER L A + ++ R + KE +E+ AL
Sbjct: 1358 ---------RLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQ 1408
Query: 1258 TDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTEL 1317
+ G DL S Q LQ++H+ E + L K+ +L A + S P E+ Q+ L
Sbjct: 1409 SSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-PAILEETQKHLRRL 1467
Query: 1318 NQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEAL 1377
L R Q +A S +L +F +SW+ S + + GA++L
Sbjct: 1468 ELLQGHLAIRGLQLQA----SVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQR 1437
+H+E + E+ A G Q G+ L A GH + I ++ L+ A+LE+A R
Sbjct: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEAR 1583
Query: 1438 RMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ 1497
L Q + Q + D + E W+ + +++ D G + LI KH+ + + +
Sbjct: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
Query: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
+ L A L + + R + ++ R L+ + +L + L +F
Sbjct: 1644 WSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDRELEGTLRLHEFL 1701
Query: 1558 RDVDEIEAWISEKLQTA--SDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVI 1615
R+ ++++ W++ + Q A + +DP + L K F+ ++ + R+
Sbjct: 1702 REAEDLQGWLASQKQAAKGGESLGEDPEH-----ALHLCTKFAKFQHQVEMGSQRVAACR 1756
Query: 1616 DMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675
+ SL+ERG AG V+ R L W L + + + L++ + + +
Sbjct: 1757 LLAESLLERGHSAG--PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEV 1814
Query: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLM-TSSA 1734
+ E +A + +DL + L+ HQ LE ++ E +L++L A +
Sbjct: 1815 LTQVQE-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPG 1873
Query: 1735 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGS 1794
V+ ++ + + ++ RRA+L + L +F + D SW + +
Sbjct: 1874 PQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQV 1933
Query: 1795 EDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFV 1854
E+ ++ + H+ L AEL A E Q G++ +E+Q+ L
Sbjct: 1934 EESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQ 1993
Query: 1855 EHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL 1914
+ ++ Q A + +RL+ + Q F+ E + + + + G ++ ++ L+
Sbjct: 1994 DQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLI 2053
Query: 1915 KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRK 1974
+KHE F T +D+ +++ + ++ L + +++ A R
Sbjct: 2054 RKHEVFLKVLTA-QDKKEAALRERLKTLRR-----PRVRDRLPILLQRRMRVKELAESRG 2107
Query: 1975 AKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 2034
L + F A E WI LK DL L K + F+A +QA
Sbjct: 2108 HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA-H 2166
Query: 2035 QEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKV 2094
+E + ++ + LLA H ++ + R L K W L A R ++L + ++
Sbjct: 2167 EEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN----- 2221
Query: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS---AQAD 2151
FL F ++ +W + E + LE LR FR + + A
Sbjct: 2222 ---FLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278
Query: 2152 FNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKL 2211
+++L Q+K+ +P EE KII +R +L N
Sbjct: 2279 IRSISDLSLQLKN----RDP---------EEV-----KIICQRRSQLNNRWASFHGNLLR 2320
Query: 2212 RQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATK---------RKHQ---- 2258
Q+ + A H +E L + + ++E L L+ K RKH+
Sbjct: 2321 YQQQLEGALEIHVLSRE----LDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELER 2376
Query: 2259 EIRAMRSQLKKIE-DLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQI 2317
E+ +++Q++ +E ++G + + + H +A+ W QL + + L+
Sbjct: 2377 EVHPIQAQVESLEREVGRLCQRSPEAAHG-LRHRQQEVAESWWQLRSRAQKRREALDALH 2435
Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRL---------NHQEFKSCLRS 2359
QA+ + +E L + D + R HQE K+ L S
Sbjct: 2436 QAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDS 2486
Score = 289 bits (740), Expect = 2e-77
Identities = 224/953 (23%), Positives = 433/953 (45%), Gaps = 22/953 (2%)
Query: 30 KELSTLR------RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDP-TNLQGKL 82
+ELS+L + +L+ + Q F E++E+W+ K + E DP ++ L
Sbjct: 2521 QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL 2580
Query: 83 QKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKG 142
KH+ E +++ +G I L+ T + GH +++ R + + E L + +
Sbjct: 2581 WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR 2640
Query: 143 IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE 202
+L + ++L +L++ ++V W+ +K + E L LQK+ + FQ ++ A
Sbjct: 2641 HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQ-QNFQAELDASM 2699
Query: 203 ERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNR 262
+ E+ + +L+Q HP E I+ + +E+ A W L+ + ++ KL A E R R
Sbjct: 2700 HQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRR 2759
Query: 263 DVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDK----VKALCAEA 318
++E +W++ E + + G+ L V LL G +R+L A DK +AL +A
Sbjct: 2760 SMEELENWLEPIEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQA 2815
Query: 319 DRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVT 378
+ A ++ + L+ ++ +R ER L L +F D + +WV
Sbjct: 2816 QAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQ 2875
Query: 379 EMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV 438
E L A + ++ L ++HQ + E+ +HE + +G L+ AGH+A+ EV
Sbjct: 2876 EKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEV 2935
Query: 439 REKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS 498
++ L + A L RR +Q + Q F + + +W++++ L +ED+G S
Sbjct: 2936 AARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHS 2995
Query: 499 LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNAL 558
++ +ALL++ E ++ L A +I L + A L + V + A+ L
Sbjct: 2996 AEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAEL 3055
Query: 559 HERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAF 617
RA R L + L Q R++ L +W+ K TA + Y +D ++ +K AF
Sbjct: 3056 LRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAF 3115
Query: 618 EAEL-SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
E+ S Q+++ AL K L + A+ + + + W++L +A + + L
Sbjct: 3116 RKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAA 3175
Query: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736
A++ F + +++ + E + +D G L++V+ LQ++H LE ++ A + +
Sbjct: 3176 AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVAR 3235
Query: 737 ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796
+ +A + + K QEA + L+ R Q LA + + ++
Sbjct: 3236 LQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGRCQEL 3291
Query: 797 ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856
W +E++ +A+S +D+ G + LL +H+ L EI + + + Q+G +V+ HF
Sbjct: 3292 LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHF 3351
Query: 857 AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
+ +V L EL + + L+ + R Q +S Q+ +AE+W+ E ++
Sbjct: 3352 MSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKP 3411
Query: 917 DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
DYG E LL +H+ L L+A +++ + P + + G+
Sbjct: 3412 DYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGR 3464
Score = 268 bits (684), Expect = 6e-71
Identities = 200/833 (24%), Positives = 389/833 (46%), Gaps = 12/833 (1%)
Query: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
A+ R Q +L R + RR +LE+ + Q F +D++E+ W++EK +A +E
Sbjct: 2615 AQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEG 2674
Query: 72 YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
D L +LQK Q F+AE+ A+ +L G ++ GH ASE I+ RL EL W
Sbjct: 2675 LLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALW 2734
Query: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
L + ++K KL +A + ++ R E++ +W+ E + + +GQ L V L
Sbjct: 2735 GELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQ 2794
Query: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLA---LQRQ 248
E + + + + A ++E H L + +++ QR K L +R+
Sbjct: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHC---LAQDVEEQARRLLQRFKSLREPLQERR 2851
Query: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
L + + +F RD DE ++W++EK L A+ D+G+ L++V+ L +H+ LE ++++ E
Sbjct: 2852 TALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHE 2911
Query: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
+ + +L Q+ +A ++ + ++L +R AA R L + Q+FL
Sbjct: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
Query: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
+ + SW+ E +++++++ +ALL R + K +++A + ++ L
Sbjct: 2972 ELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLE 3031
Query: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
+ + S +V +L + E A LL E R ++ + L R+T +D W++ + A
Sbjct: 3032 SRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAA 3091
Query: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQEEKITALDEFATKLIQNNHYAMEDVATR 547
++D G L+ V+ L +K + F K + S + K+ AL + A L + + +
Sbjct: 3092 TAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQ 3151
Query: 548 RDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTAT-DEAYKDPSN 606
R + + L + R LA + + F + + EL+ + EK ++ S+
Sbjct: 3152 RSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSS 3211
Query: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
++ Q+H+ E EL A + + L+ +L ++ A +A +V W L
Sbjct: 3212 VRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA----KVQEAWATLQAK 3267
Query: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
+ +G L +A Q F +++ W E + +S++ +D+ + L +H L +
Sbjct: 3268 AQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQE 3327
Query: 727 VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
+ + + + + +Q D HF + + + + L R + L+E R Q+ A+S L
Sbjct: 3328 IRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGL 3387
Query: 787 QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR 839
Q+L + +E E W+ E + + G + V+ LL +HQ L+ +A E +
Sbjct: 3388 QKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEK 3440
Score = 223 bits (569), Expect = 1e-57
Identities = 158/519 (30%), Positives = 253/519 (48%), Gaps = 6/519 (1%)
Query: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
A ++ R QQ+ + + RR L+ + Q F + E W+ E+ + E+
Sbjct: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991
Query: 72 YKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Q L++ +A + +++A S I +L +T L+ S + S + +L +
Sbjct: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREA 3051
Query: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
LL + +G L + +L Q RE + W+ K A S++ GQDLE V+VL++K
Sbjct: 3052 HAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEK 3111
Query: 191 FEEFQTDMAA-HEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
F+ F+ ++ + + +V + + A L + I+ ++ + AAW+RL R
Sbjct: 3112 FDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
L A EV F + E ++EK LM +D G L+SV+ L ++H LER+L A+E
Sbjct: 3172 NLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEK 3231
Query: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
+V L EA RL Q HP + + +E W ++ A ER L + + FL
Sbjct: 3232 EVARLQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGR 3287
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
++L +W E + L +++ELA DVAGAE LL +H+E EI + + GQ L+
Sbjct: 3288 CQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVD 3347
Query: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
H+ S EV E L L L E W LR Q+ + LQ + EQ + W++ E
Sbjct: 3348 NSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGL 3407
Query: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528
LL D G S+ VE LL +H+D EK L+AQEEK + +
Sbjct: 3408 LLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQK 3446
Score = 127 bits (320), Expect = 1e-28
Identities = 137/569 (24%), Positives = 246/569 (43%), Gaps = 34/569 (5%)
Query: 1493 AINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL-KAQMIEKRS-----K 1546
A V E+++ Q + +AA + I + + RL + Q +++R +
Sbjct: 206 AFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQ 265
Query: 1547 LGESQTLQ-QFSRDVDEIEAWISEKLQTASDESYKD--PTNIQLSKLLS---------KH 1594
L E++ LQ Q+ + V ++ WI+EK + D P QL + +
Sbjct: 266 LQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRL 325
Query: 1595 QKHQAFEAELHANADRIRG------VIDMGNSLIERGAC-AGSEDAVKARLAALADQWQF 1647
Q+ A EA L ++ + G L E C AG E A AR AL Q
Sbjct: 326 QQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQ---QR 382
Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 1707
L+Q ++ + +K + +KD + L + A AS LA+V +++ +
Sbjct: 383 LLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS------LATVEAAVQRLGM 436
Query: 1708 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE 1767
LEA I E R + L AD L + V +++ + R+Q++ +R ++ +
Sbjct: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
Query: 1768 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
+ ++++ ++E + S G+ L V L ++H LEA+++AH +
Sbjct: 497 MQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH 556
Query: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
+ +L E +Q + + + L L AR LE++L+ +F+ N EEE
Sbjct: 557 LAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE 616
Query: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH 1947
EAW+ E V + G L+ I G L+KH+A E + H+ D+ G+DL +
Sbjct: 617 EAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPP 676
Query: 1948 HEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTD 2007
+ + + + + G L+ R A+L LQ+ A SW+ E+ +SL+
Sbjct: 677 TQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERA 736
Query: 2008 DYGRDLSSVQTLLTKQETFDAGLQAFQQE 2036
G+D ++ +TLL + + L+AF E
Sbjct: 737 SCGQDQAAAETLLRRHVRLERVLRAFAAE 765
Score = 123 bits (309), Expect = 2e-27
Identities = 211/1120 (18%), Positives = 440/1120 (39%), Gaps = 125/1120 (11%)
Query: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
++ LQ++ +L Q +L +R Q KA L +S FL D ++ +++
Sbjct: 376 SQALQQRLLQL-QRLETLARRF-QHKAALRES-----FLKDAEQVLDQARAPPASLAT-- 426
Query: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEI-KQKLDILDQ 1425
EA ++R I + G FQA + L +++ ++ +++ ++ +
Sbjct: 427 -------VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVR 479
Query: 1426 ERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIK 1485
+ L+ QR+ + D L L ++ E A + + + + G L V L++
Sbjct: 480 WQRLLQHLQGQRKQVADMQAVLSLL-QEVEAASHQLEELQEPARSTACGQQLAEVVELLQ 538
Query: 1486 KHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRS 1545
+H+ + ++ ++ L +L ++ + + ++ + + L A + +R+
Sbjct: 539 RHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598
Query: 1546 KLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
L ++ +F R+ +E EAW+ E Q + + LS++ QKH+A EAE+H
Sbjct: 599 LLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAAL----GRDLSQIAGALQKHKALEAEVH 654
Query: 1606 ANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ 1665
+ ++ G L R + +A A+ WQ L + + +L+ A
Sbjct: 655 RHQAVCVDLVRRGRDLSARRPPTQPDPGERAE--AVQGGWQLLQTRVVGRGARLQTALLV 712
Query: 1666 QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
+ + WL E + L G+D A+ LL++H LE + A L+ L Q
Sbjct: 713 LQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQ 772
Query: 1726 AD------SLMTSSA---------------------------------------FDTSQV 1740
SL T ++ FD + +
Sbjct: 773 GRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTI 832
Query: 1741 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800
+D ++ ++ ++++A RRA+L E+ L F + + W++++ +L+ D
Sbjct: 833 LQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQAD 892
Query: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1860
V L K++ LA + V + ++L +IQ++ + + W +L
Sbjct: 893 TLEVMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQL 950
Query: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG---DTLAAIQGLLKKH 1917
+ L + +L S+E F+ + + + + + + G DT A+Q KK
Sbjct: 951 EALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT 1010
Query: 1918 EAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKL 1977
E RV+ + + + + + + +++ L G + +++ AQR +
Sbjct: 1011 LVLER-------RVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQ 1063
Query: 1978 DENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
E A F ++ + W + L++ + D++S Q LL + + + + QE
Sbjct: 1064 AETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLW-QER 1122
Query: 2038 IANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKV 2094
+ + A + A S+ + L ++ +L R++ L LE Q R+V
Sbjct: 1123 LQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREV 1182
Query: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQ 2154
+ T A + + +N ED + E +L + H F LS+
Sbjct: 1183 DGFTATCANHQAWLH--LDNLGED---------VREALSLLQQHREFGRLLSTLGPRAEA 1231
Query: 2155 L-AELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR- 2212
L A ++ ++S A++ +++++ W LQ + EQRR++ L+
Sbjct: 1232 LRAHGEKLVQSQHPAAHTVR-EQLQSIQAQWTRLQG---------RSEQRRRQLLASLQL 1281
Query: 2213 QEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKR---KHQEIRAMRSQLKK 2269
QE+ Q QW++E E SG + L+ KR E+ A R ++
Sbjct: 1282 QEWKQDVAELMQWMEEKGLMAAH-----EPSGARRNILQTLKRHEAAESELLATRRHVEA 1336
Query: 2270 IEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA 2329
++ +G + + + GL +W+ L++ L+Q Q ++A
Sbjct: 1337 LQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDA 1396
Query: 2330 LKEFSMMFKHFDKDKSG---------RLNHQEFKSCLRSL 2360
++ + ++G + HQ+ +S R+L
Sbjct: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTL 1436
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 609 bits (1570), Expect = e-173
Identities = 402/1417 (28%), Positives = 707/1417 (49%), Gaps = 78/1417 (5%)
Query: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
+E I+ER + +++ ++LS +R+++LE++ FQ DA++++ W+ + L+I S +
Sbjct: 699 SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 758
Query: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
D + Q ++KH+ E+ + L E + + E H S +R RL + +
Sbjct: 759 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEER 817
Query: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
++ + E R + L L + E + WI++KE + + ++ + LE +EV+Q +
Sbjct: 818 YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 877
Query: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK 250
FE + +M RV VNQ A +L+ HP E+ IK +QD++N W + + L +++
Sbjct: 878 FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 937
Query: 251 LFGAAEVQRFNRDVDETISWIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALED 309
L A +Q ++ + +ET SWI+EK +++ S D G DLA V AL RK G+ERDL A+E
Sbjct: 938 LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 997
Query: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
K+ L EA++L+ HP A I + E+ WE+++T R A L ++ +LQ+FL D
Sbjct: 998 KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRD 1057
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
D SW++ + I ++++ + + AE LL +H+ K EID +E+ ++ + G+ +
Sbjct: 1058 LDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ 1117
Query: 430 AGHYASDE-VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
A +R++L L L ++WE R+ Q Q F RDT+Q + +++ QE
Sbjct: 1118 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1177
Query: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
L + ++ +L+ EA +KK EDF ++ A EEKI A+ E +L+ + + + + +
Sbjct: 1178 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1237
Query: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
D++ R E A +L D+ LQ+F +D EL W+NEKM TA D +Y + NL
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1297
Query: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668
K KHQAF AEL++N+ +D +EK G +LI + V ++ + +W+ L T+
Sbjct: 1298 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1357
Query: 669 LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728
K +L +AN+ + F ++ D++ WL+ +E + SDDYGKDLT+V L KK +LE +
Sbjct: 1358 TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQME 1417
Query: 729 AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
+ I+ + QA+ G + + K+ + ++ L EP+ RK L S + Q
Sbjct: 1418 VRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ 1476
Query: 789 LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG- 847
RDVEDE W+ E+ P+A ST+ G +L VQ L+KK+Q LQ EI GH+PRI + ++
Sbjct: 1477 FNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQ 1536
Query: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
N + + +AE ++ +L +L Q W L + +R + LE++ +AQQY+ DA EAE+WM
Sbjct: 1537 NIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1596
Query: 908 EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
E+E + S + KDE SA ++LKKH+ L + Y ++ L + +++ P +
Sbjct: 1597 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1656
Query: 968 G------KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYV 1021
+L L D E+ R + + L LN EV+D + ++ V
Sbjct: 1657 SMRQSKVDKLYAGLKDLAEE--RRGKLDERHRLFQLNR--------EVDDLEQWIAEREV 1706
Query: 1022 --KKLDPAQSASRENLLEEQ--------GSIALRQEQIDNQTRITKE--------AGSVS 1063
+ Q +L+E+ G+I QE++D + E A +++
Sbjct: 1707 VAGSHELGQDYEHVTMLQERFREFARDTGNIG--QERVDTVNHLADELINSGHSDAATIA 1764
Query: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
+ E + LLEL + R +L S + + +A E+ I +K L EE+G D
Sbjct: 1765 EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQ 1823
Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
VE LQ+ F+ D++A ++++ + + A L++ ++ +Q++E
Sbjct: 1824 NTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQA-AYAGDKADDIQKRE--------- 1873
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
E+ E W+SL E R L + RF
Sbjct: 1874 -------------------------NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1908
Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
+ W+E+ + + D++SV+ L H+G + ++ A D + E + L+
Sbjct: 1909 DLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1968
Query: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
++E+++EK +L + + + + R L ++ +F D +W+ G +S
Sbjct: 1969 HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLS 2028
Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
S E+ + V E L++RH+ F A E+
Sbjct: 2029 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALER 2065
Score = 565 bits (1455), Expect = e-160
Identities = 403/1511 (26%), Positives = 737/1511 (48%), Gaps = 84/1511 (5%)
Query: 26 YHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDENY-KDPTNLQGKLQ 83
Y +L+ RR +LE+S R ++FF AEE E WI+EK +I S ++Y KD T++ L
Sbjct: 607 YQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEKILSSDDYGKDLTSVMRLLS 665
Query: 84 KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGI 143
KH+AFE E+ SG + + G MI+E HF SE IR R++ + QW L + +
Sbjct: 666 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 725
Query: 144 KLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
+L +A L Q+ + +D+ W+ D IV+S ++G D + L KK ++ ++A +
Sbjct: 726 RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 785
Query: 204 RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
++ +++ A+ L QE H E ++ + + ++ + L R+ L + + +
Sbjct: 786 TLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 844
Query: 264 VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
D WI EKEQ + + L ++ + + E LE ++ +V + A +L
Sbjct: 845 ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 904
Query: 324 SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEM-KA 382
S S +I+ ++++L T W Q R L + L + +Q + + + SW+ E K
Sbjct: 905 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 964
Query: 383 LINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKL 442
+ + +L +D+AG AL + + ++ A E + + L + + + +L
Sbjct: 965 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1024
Query: 443 TVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSV 502
+S+ + + R + LQ F RD + +W+S+ + + +ED+ ++L
Sbjct: 1025 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEA 1084
Query: 503 EALLKKHEDFEKSLSAQEE---KITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALH 559
E LL +HE+ + + EE K+ + E T+ + Y + R AL + N LH
Sbjct: 1085 EKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMF--LRQRLQALDTGWNELH 1142
Query: 560 ERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGK---VQKHQA 616
+ R+ L+ S QQF RD+ + ++++N + P+ L+G ++K +
Sbjct: 1143 KMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEM--PTTLEGAEAAIKKQED 1200
Query: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
F + AN+ +I+A+ + G++L+ + D + +++ + +K E ++L++
Sbjct: 1201 FMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKD 1260
Query: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEADVAAHQDRID 735
Q+F ++ +++ LW+ E L + D D N+ + KH A++A++++ +D
Sbjct: 1261 NRDLQKFLQDCQELSLWINEKM--LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLD 1318
Query: 736 GITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED 795
I + Q +K+K L +E L+ + Q+L D+ + + + D
Sbjct: 1319 KIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCAD 1378
Query: 796 EETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGH 855
+ W+ E S + GKDL V LLKK Q L+ ++ + I+ + + A+ +EG
Sbjct: 1379 LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1438
Query: 856 FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGS 915
+ ++V +K + K+ L ++R+ +L S + Q+ D + W+ E+ P+ S
Sbjct: 1439 -STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATS 1497
Query: 916 TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC------------RQQVAPT 963
TD+G + + + L+KK++ L ++ + I + E++Q+ RQ++A
Sbjct: 1498 TDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADL 1557
Query: 964 DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKK 1023
K+L L + EK R + ++ + W E + K
Sbjct: 1558 -----KQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE--QELYMMSEEKAKD 1610
Query: 1024 LDPAQSASRENLLEEQG--SIALRQEQIDNQTRIT-----KEAGSVSLRMKQVEELYHSL 1076
A S +++ + EQ A Q+ +R E+ +S+R +V++LY L
Sbjct: 1611 EQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGL 1670
Query: 1077 LELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDF 1136
+L E+R+G L++ + F L RE ++L+QWI E+E S E+G D E V +LQ++F +F
Sbjct: 1671 KDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREF 1730
Query: 1137 QKDL-KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSA 1195
+D + R+ +N +A++L + G +D+ T + WK
Sbjct: 1731 ARDTGNIGQERVDTVNHLADELINSG---------------------HSDAATIAEWKDG 1769
Query: 1196 RLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQA 1255
LNE W L +L + R+Q+L +++E+ +F+ DA E I++K++
Sbjct: 1770 ---------------LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKK 1814
Query: 1256 LNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKC 1314
L + G D +V+ LQR H FE D+ ALG +V L E A RL ++ + A+D+Q++
Sbjct: 1815 L-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRE 1873
Query: 1315 TELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGA 1374
E+ +AW SL + R+ +L D+ D RF S RDLM W+ + + + E +DV+
Sbjct: 1874 NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1933
Query: 1375 EALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAW 1434
E L+ HQ + EIDAR +F + G+ LLA HYAS EIK+KL L ++R ++ W
Sbjct: 1934 ELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKW 1993
Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
R L LE+ F RD AE W+ +E +L++ + G S+D VE LIK+HE F+K+
Sbjct: 1994 EDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSA 2053
Query: 1495 NVQEEKIAALQ 1505
+E+ +AL+
Sbjct: 2054 ATWDERFSALE 2064
Score = 519 bits (1337), Expect = e-146
Identities = 394/1716 (22%), Positives = 798/1716 (46%), Gaps = 82/1716 (4%)
Query: 35 LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYK-DPTNLQGKLQKHQAFEAEVQ 93
+R++KLE R F R A E W+ E ++ S +N+ D ++ +KH+A E ++
Sbjct: 402 IRQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIA 459
Query: 94 ANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ 153
A + + + +E + + I R + R WE LLE +R + +L L +
Sbjct: 460 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 519
Query: 154 YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAA 213
+E +MDW+++ + +V S++ G+ L VE L +K + D+ ERV VN A
Sbjct: 520 IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQ 579
Query: 214 KLIQEQHP----EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS 269
K + + ++I+ + + +Q L LA +R+ +L + + +F ++ E
Sbjct: 580 KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG 639
Query: 270 WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSA 329
WI+EKE++++SDD+G+DL SV LL KH E +++ + E + + +
Sbjct: 640 WIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGS 699
Query: 330 TQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADEL 389
+I+ + + W + L+A R RL ++ L +F AD D+ +W+ ++ ++++ ++
Sbjct: 700 EKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV 759
Query: 390 ASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEER 449
D ++L+ +H++ EI + + + E AL H S +VR +L+ + E
Sbjct: 760 GHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERY 818
Query: 450 AALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKH 509
+ EL LR+Q + + L + + + + W+ ++E +L N + + L+ +E + +
Sbjct: 819 KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 878
Query: 510 EDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQL 569
E E ++ Q ++ +++ A +L+ + H + +++ ++D L +R + E R++ L
Sbjct: 879 ESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL 938
Query: 570 ADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKDPSNLQGKVQKHQAFEAELSANQSR 627
+ +Q + + +E KSW+ EK K +T + D + + +K E +L A +++
Sbjct: 939 LSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 998
Query: 628 IDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV 687
+ L+K +KL + + +R+ E+ +W+++ + + L EA++ QQF R++
Sbjct: 999 LSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDL 1058
Query: 688 EDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
+D + WL + +AS+D LT + L +H ++ ++ +++ +
Sbjct: 1059 DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ- 1117
Query: 748 GHFDAEN--IKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
G DA+ ++++ +AL + L + R+ L+ S QQ RD + E ++ +E
Sbjct: 1118 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1177
Query: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
+ A T L G + +KK + + +E +I AV + G +V +G+ ++ ++ K+
Sbjct: 1178 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1237
Query: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA 925
++ + + AS+ L+D+ Q++ D E W+ EK Y + +
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1297
Query: 926 EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDY------- 978
LK H+A M++L++ + + ++ + P + KE + L+
Sbjct: 1298 SKWLK-HQAFMAELASNKEWLDKIEKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLEST 1355
Query: 979 -QEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSA-SRENLL 1036
Q K+ R K ++ T + + D W + + Y K L ++ +L
Sbjct: 1356 TQTKAQRLFDANKAELFTQ-SCADLDKWLHGLESQ--IQSDDYGKDLTSVNILLKKQQML 1412
Query: 1037 EEQGSIALRQ-EQIDNQTRITKEAGS----VSLRMKQVEELYHSLLELGEKRKGMLEKSC 1091
E Q + ++ E++ +Q + + G V + V+ + LLE +RK L S
Sbjct: 1413 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASK 1472
Query: 1092 KKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDIN 1151
+ R+ + W+ E+ TS + G +L+ V++L KK QK+++ ++ R+ DI
Sbjct: 1473 EIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1532
Query: 1152 KVAEDL--ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIK 1209
+ ++++ +S L AE A++Q+ +
Sbjct: 1533 ERSQNIVTDSSSLSAE---AIRQR----------------------------------LA 1555
Query: 1210 ELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQ 1269
+L + W L + E+R + L AH Q+++ DA E + W+ E+ + ++ D S
Sbjct: 1556 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1615
Query: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELNQAWSSLGKRA 1328
++ +KH+ E+ + + V+ L +T+ L+ SHPES E + + +++++ ++ L A
Sbjct: 1616 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPES-ERISMRQSKVDKLYAGLKDLA 1674
Query: 1329 DQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEI 1388
++R+ KL + H L + + DL WI + S EL +D L ER +E +
Sbjct: 1675 EERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDT 1734
Query: 1389 -DARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLEL 1447
+ +L+ GH + I + D L++ ADL + R +L EL
Sbjct: 1735 GNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYEL 1794
Query: 1448 QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAF 1507
F+ D ++ + + L E+ G ++VE L + H F+ I ++ LQ
Sbjct: 1795 HKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQED 1853
Query: 1508 ADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566
A +L AA K D I R NEVL+ W+ L +R +L ++ +F V ++ W
Sbjct: 1854 AARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLW 1913
Query: 1567 ISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626
+ + ++ E+ + P ++ +LL + HQ +AE+ A D I++G SL+ R
Sbjct: 1914 MEDVIRQI--EAQEKPRDVSSVELLMNN--HQGIKAEIDARNDSFTTCIELGKSLLARKH 1969
Query: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686
A E +K +L L ++ + ++ K ++ + L+ + F+ + WL E L
Sbjct: 1970 YASEE--IKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2027
Query: 1687 ASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1722
+S + G+ + V L+K+H+ E + ++R L
Sbjct: 2028 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL 2063
Score = 517 bits (1331), Expect = e-146
Identities = 432/1940 (22%), Positives = 865/1940 (44%), Gaps = 139/1940 (7%)
Query: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQEH-----------KGEIDAHEDSFKS- 419
DL W+ + ++N + A+ + G + L + KG ++ + +S
Sbjct: 300 DLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSK 359
Query: 420 --ADESGQALLAAGHYASD--EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
A+ + G SD + E+L ER L +R+++ EQ + F R
Sbjct: 360 MRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLA--RRFDRK 417
Query: 476 TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
+ W+S+ + + ++ G L +VEA KKHE E ++A EE++ A+ A +L
Sbjct: 418 AAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEA 477
Query: 536 NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT 595
N++ ++ + R+D ++ L E RR +L + LQ+ F++ + W++E
Sbjct: 478 ENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVL 537
Query: 596 ATDEAY-KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAK----DEVA 650
+ Y K ++ +QKH EA++ R+ + + QK K +
Sbjct: 538 VLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR 597
Query: 651 ARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDL 710
R+ + +++L + + +L E+ + +F + + E W+ E E L+SDDYGKDL
Sbjct: 598 DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 657
Query: 711 TNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALK 770
T+V L KH E +++ + + HF +E I+++ + ++ L+
Sbjct: 658 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLE 717
Query: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830
+ RK++L ++ L Q D +D + W+ + I +S++ G D Q+L+KKH+ +
Sbjct: 718 QLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVA 777
Query: 831 AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890
EIA + P + + ++ +A+ +E H + DV+ +L + ++++ + R+Q L+D+L
Sbjct: 778 EEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 836
Query: 891 QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
+ F++A+ E W+ EKE + + + + E + + E+L +++ S + +
Sbjct: 837 ALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 896
Query: 951 EQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVN 1010
+ A+ P++ E K L + V KK +L+ L+ N + +E N
Sbjct: 897 QIARQLMHSGHPSEKEI-KAQQDKLNTRWSQFRELVDRKKDALLSALSIQN---YHLECN 952
Query: 1011 DRQGFVPAAYVKKLDPAQ----------SASRENLLEEQGSIALRQEQIDNQTRITK--- 1057
+ + ++ K ++ Q + R+ E+ +A+ + D Q K
Sbjct: 953 ETKSWIREK-TKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLES 1011
Query: 1058 ----EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
+A ++ R+ ++ +++ + + R+ L ++ K R+ ++ Q W++ + A
Sbjct: 1012 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTA 1071
Query: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
+ SE++ L + E L L +E+ +I+ ED + M E V Q
Sbjct: 1072 IASEDMPNTLTEAEKL----------LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1121
Query: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
Y + + ++ L+ W L ++ E R LL +H
Sbjct: 1122 AQYMFLRQ-------------------------RLQALDTGWNELHKMWENRQNLLSQSH 1156
Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
Q+F RD + + ++ + L L +A +K E F + A +K+N++
Sbjct: 1157 AYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVV 1216
Query: 1294 ETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMS 1353
ET RL+ +++ +QEK ++ + A + +L D+ DLQ+FL D ++L
Sbjct: 1217 ETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSL 1276
Query: 1354 WINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYAS 1413
WIN + L + D + + +HQ E+ + E+ G QL++
Sbjct: 1277 WINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETE 1335
Query: 1414 PEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK 1473
+K+KL L + LE + L + +LF + C + W+ E+ + ++D
Sbjct: 1336 AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDY 1395
Query: 1474 GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRW 1533
G L SV L+KK + + + V++++I LQ+ A L G + ++ S+R V ++
Sbjct: 1396 GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKF 1454
Query: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
L + E++ L S+ + QF+RDV++ W+ E++ A+ + N+Q +LL K
Sbjct: 1455 MELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH--NLQTVQLLIK 1512
Query: 1594 HQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSA 1653
K+Q + E+ + RI + + +++ + +E A++ RLA L W L++++
Sbjct: 1513 --KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE-AIRQRLADLKQLWGLLIEETE 1569
Query: 1654 EKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADIS 1713
++ ++L+EA++ Q + + + W+SE E + SE+ KD S ++LKKHQ+LE +
Sbjct: 1570 KRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVE 1629
Query: 1714 AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ 1773
+ + + L+ + +L+ S ++ ++ ++ ++ + +K +A RR KL+E HRL Q
Sbjct: 1630 DYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQ 1689
Query: 1774 FFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAI-QGVLDTG 1832
R++DD E WI E++++ GS + G+D V L+++ + E A I Q +DT
Sbjct: 1690 LNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR----EFARDTGNIGQERVDTV 1745
Query: 1833 KKLSDDNTIGKEEIQQRLAQFV----EHWKELKQLAAARGQRLEESLEYQQFVANVEEEE 1888
L+D+ +A++ E W +L +L R Q L S E +F + +E
Sbjct: 1746 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIF 1805
Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHH 1948
I +K + E+ G ++ L + H FE D +V + + L
Sbjct: 1806 GRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGD 1864
Query: 1949 EENISSKMKG--LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKT 2006
+ + K + L S L+ ++R +D F F+ D++ W+ + ++
Sbjct: 1865 KADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM-LWMEDVIRQIEA 1923
Query: 2007 DDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASL 2066
+ RD+SSV+ L+ + A + A + + L LLA KH S+ I+ + L
Sbjct: 1924 QEKPRDVSSVELLMNNHQGIKAEIDA-RNDSFTTCIELGKSLLARKHYASEEIKEKLLQL 1982
Query: 2067 MKRWSQLLANSAARKKKL-LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRC 2125
++ +++ R + L L + H F++ AS +W E L+
Sbjct: 1983 TEKRKEMIDKWEDRWEWLRLILEVH---------QFSRDASVAEAWLLGQEPYLSSREIG 2033
Query: 2126 NSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR 2185
S++E++ L + H+AF S ++ F+ L L T+E LE
Sbjct: 2034 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLT----------------TLELLE---- 2073
Query: 2186 NLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT 2245
R + ++E++R+ + + + ++ A + QW + E+
Sbjct: 2074 -------VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSP 2126
Query: 2246 LESQLEATKRKHQEIRAMRS 2265
S T + ++ + R+
Sbjct: 2127 RVSYRSQTYQNYKNFNSRRT 2146
Score = 509 bits (1310), Expect = e-143
Identities = 414/1901 (21%), Positives = 839/1901 (44%), Gaps = 122/1901 (6%)
Query: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQ--RQGKLFGAA-----EVQRFNRDVDETI 268
I HP+E+ I T + ++K LA++ R GK+ A ++++ + +
Sbjct: 243 ISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL 302
Query: 269 SWIKEKEQLMASDDFGRDLASVQALLRKHE---------------GLERDLAALEDKVKA 313
WI++ ++ + F L VQ L+ LE L ++ K++A
Sbjct: 303 EWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRA 362
Query: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ--------R 365
+ ++ +S ++ WE++ ER L + Q R
Sbjct: 363 NNQKVYMPREGKLIS---------DINKAWERLEKAEHERELALRNELIRQEKLEQLARR 413
Query: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
F +W++E + L++ D D+ EA +H+ + +I A+E+ ++ +
Sbjct: 414 FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR 473
Query: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
L A ++ + + + LLEL RRQ+ E + LQ +++ + +WM +
Sbjct: 474 ELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDE 533
Query: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH-YAMEDV 544
+ +L++D G L VE LL+KH E + Q E++ ++ A K + Y D
Sbjct: 534 MKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDP 593
Query: 545 ATRRDALLSRR---NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY 601
RD + L + A RRA+L +S L +FF + E + W+ EK K + + Y
Sbjct: 594 QVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDY 653
Query: 602 -KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
KD +++ + KH+AFE E+S + K G+ +I H+ +++ R+ + W
Sbjct: 654 GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQW 713
Query: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
L + + ++ +L EA+ QF + +DI+ W+ ++ ++S D G D + Q+L KKH
Sbjct: 714 ANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH 773
Query: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
+ ++A ++ +D + QA H ++ +++ + + RY+ + E RKQ L
Sbjct: 774 KDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQAL 832
Query: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
D+L L ++F + + E WI EKE + + L ++ + + ++L+ E+ R+
Sbjct: 833 QDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRV 892
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
V Q ++ GH + +++KA+ +LN +W + +++ L +L Q Y + N
Sbjct: 893 AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECN 952
Query: 901 EAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
E +SW+REK ++ ST D G D AL +K + DL A + + L+++A+ +
Sbjct: 953 ETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE 1012
Query: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVP-- 1017
+ + ++ L + + T K +L ++ + +++D Q ++
Sbjct: 1013 ----HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1068
Query: 1018 -AAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL------------ 1064
A + P E LL + +I + + + ++ G +
Sbjct: 1069 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1128
Query: 1065 -RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
R++ ++ ++ L ++ E R+ +L +S R+ + + ++N +E L E+ L
Sbjct: 1129 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTL 1188
Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
E E KK +DF + ANE ++ + + L S+G + + + QE
Sbjct: 1189 EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDG----NINSDRIQE--------- 1235
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
+ +++R R ++ A E L ++Q+F +D
Sbjct: 1236 -----------------------KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ 1272
Query: 1244 ETKEWIEEKNQALNTDNYGHDLA-SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
E WI EK L + +D A ++ + KH+ F +LA+ + ++ + + +LI
Sbjct: 1273 ELSLWINEK--MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE 1330
Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
PE+ ++EK T L++ W L + +L D++ + F DL W++G+ +
Sbjct: 1331 KPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQI 1390
Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422
SD+ KD+T LL++ Q +++ R + + Q L G ++ E+ K
Sbjct: 1391 QSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLT 1449
Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482
+ + +L + +R+ L E+ F+RD E W+ R + D G +L +V+
Sbjct: 1450 VQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQL 1509
Query: 1483 LIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQMI 1541
LIKK++ K I + +I + + ++ + I R ++ W L +
Sbjct: 1510 LIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETE 1569
Query: 1542 EKRSKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQLSKLLSKHQKHQAF 1600
++ +L E+ QQ+ D E EAW+SE+ L S+E KD + +S +KHQ
Sbjct: 1570 KRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSA-----VSMLKKHQIL 1624
Query: 1601 EAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLK 1660
E + A+ + + +L+ + + R + + + L + E+ KL
Sbjct: 1625 EQAVEDYAETVHQLSKTSRALVADSH--PESERISMRQSKVDKLYAGLKDLAEERRGKLD 1682
Query: 1661 EANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRL 1719
E ++ N + D + W++E E + S + G+D V L ++ + D + ++R+
Sbjct: 1683 ERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERV 1742
Query: 1720 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMD 1779
+N AD L+ S D + + + +D +N + + + +R L S+ LH+F+ D
Sbjct: 1743 DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAK 1802
Query: 1780 DEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN 1839
+ I++K + E+ GRD V+ L++ H E ++ A ++ + + +L
Sbjct: 1803 EIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAY 1861
Query: 1840 TIGK-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLV 1898
K ++IQ+R + +E WK L +R RL ++ + +F + V + W+ + + +
Sbjct: 1862 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI 1921
Query: 1899 ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG 1958
+++ +++++ L+ H+ + + D G+ L+ + ++ E I K+
Sbjct: 1922 EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1981
Query: 1959 LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQT 2018
L K ++ R L QF+ A V E+W+ +E L + + G+ + V+
Sbjct: 1982 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEK 2041
Query: 2019 LLTKQETFDAGLQAFQQ--EGIANITALKDQLLAAKHVQSK 2057
L+ + E F+ + + + +T L +LL + Q +
Sbjct: 2042 LIKRHEAFEKSAATWDERFSALERLTTL--ELLEVRRQQEE 2080
Score = 498 bits (1283), Expect = e-140
Identities = 431/1843 (23%), Positives = 824/1843 (44%), Gaps = 126/1843 (6%)
Query: 146 LQAQKLVQ-YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQT--DMAAHE 202
++ +K+++ Y D+++WI I+ + + L V+ + F ++T
Sbjct: 285 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 344
Query: 203 ERVN-EVNQFAAKLIQEQHPEEELIKTKQ---DEVNAAWQRL------KGLALQ----RQ 248
E+ N EV F + + ++ + + ++N AW+RL + LAL+ RQ
Sbjct: 345 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 404
Query: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
KL A +RF+R +W+ E ++L++ D+FG DL +V+A +KHE +E D+AA E
Sbjct: 405 EKLEQLA--RRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYE 462
Query: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
++V+A+ A A L+ + +I +++ +I WE + L R RL + LQ+
Sbjct: 463 ERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQ 522
Query: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ--A 426
+ + W+ EMK L+ + + + G E LL +H + +I + + + S Q A
Sbjct: 523 EMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFA 582
Query: 427 LLAAGHYASDE--VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
G+ D +R+++ + L +L RR + E+ L F+ + + + W+
Sbjct: 583 TDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIR 642
Query: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
++E L ++D G L SV LL KH FE +S + + +I H+ E +
Sbjct: 643 EKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKI 702
Query: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKD 603
R + + L + + R+ +L ++ L QF D+D++ +W+ + +K ++ + D
Sbjct: 703 RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD 762
Query: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
+ Q V+KH+ E++ + +D L + L H +V R++ + +K++
Sbjct: 763 EYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEV 821
Query: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
E T L+ L++ + + ELW+ E E L + + L +++ +Q + L
Sbjct: 822 AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESL 881
Query: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
E ++ R+ + ARQ +GH + IK +Q+ L R+ +E + +K L +
Sbjct: 882 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSA 941
Query: 784 LRLQQLFRDVEDEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
L +Q + + ++WIREK + ST + G DL GV L +K ++ ++ E ++
Sbjct: 942 LSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSD 1001
Query: 843 VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
+ ++ + E A+ + ++L E++ WE +K R L ++ + QQ+ D ++
Sbjct: 1002 LQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDF 1061
Query: 903 ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE----------- 951
+SW+ + + S D AE LL +HE + +++ Y Q +R+
Sbjct: 1062 QSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1121
Query: 952 -QAQSCRQQVAPTDD---------ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTN 1001
Q RQ++ D E + L+ + YQ+ R+ + LN+
Sbjct: 1122 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQ-FLRDTKQAE----AFLNNQE 1176
Query: 1002 KDWWKVEVNDRQGFVPAAYVKKLD--PAQSASRE--NLLEEQGSIALRQEQIDNQTRITK 1057
E+ AA K+ D A+ E N + E G + I N RI +
Sbjct: 1177 YVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNI-NSDRIQE 1235
Query: 1058 EAGSVSLRMKQVEELYHSLL-ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
+ S+ R ++ E LL L + R +KF+ ++ EL WINEK LT+
Sbjct: 1236 KVDSIDDRHRKNRETASELLMRLKDNR------DLQKFL--QDCQELSLWINEK--MLTA 1285
Query: 1117 EEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEV 1175
+++ D + K F +L +N+ L I K L SE E +AV ++++
Sbjct: 1286 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE---KPETEAVVKEKL 1342
Query: 1176 YGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEV 1235
G L++ W L+ + ++Q L A++
Sbjct: 1343 TG---------------------------------LHKMWEVLESTTQTKAQRLFDANKA 1369
Query: 1236 QRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGET 1295
+ F + + +W+ + +D+YG DL SV L +K + E + ++ L
Sbjct: 1370 ELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1429
Query: 1296 AERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWI 1355
A+ L Q +S +++ K + + L + ++RK L S ++ +F D D + W+
Sbjct: 1430 AQALSQ-EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1488
Query: 1356 NGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE 1415
L +S + ++ + L++++Q + EI + Q ++ S E
Sbjct: 1489 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1548
Query: 1416 -IKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKG 1474
I+Q+L L Q L + +R L++ Q ++ D +AE WM+ +E ++ +E+K
Sbjct: 1549 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1608
Query: 1475 DSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWR 1534
S +++KKH+ ++A+ E + L + L+A H IS R+++V +
Sbjct: 1609 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1668
Query: 1535 RLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASD----ESYKDPTNIQLSKL 1590
LK E+R KL E L Q +R+VD++E WI+E+ A + Y+ T +Q
Sbjct: 1669 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ---- 1724
Query: 1591 LSKHQKHQAFEAEL-HANADRIRGVIDMGNSLIERGACAGSEDAVKARLA-ALADQWQFL 1648
++ + F + + +R+ V + + LI G S+ A A L + W L
Sbjct: 1725 ----ERFREFARDTGNIGQERVDTVNHLADELINSG---HSDAATIAEWKDGLNEAWADL 1777
Query: 1649 VQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLL 1708
++ ++Q L + + F K+ + + L E+ G+D +V L + H
Sbjct: 1778 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTF 1836
Query: 1709 EADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDT-INGRFQKIKSMAASRRAKLNE 1767
E DI A +++ L A L + A D + KR+ + ++ + SRR +L +
Sbjct: 1837 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1896
Query: 1768 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
+ +FF + D W+++ + +++ RD++ V+ L H+ ++AE+ A +
Sbjct: 1897 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1956
Query: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
++ GK L EEI+++L Q E KE+ R + L LE QF +
Sbjct: 1957 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2016
Query: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDR 1930
EAW+ + ++S + G ++ ++ L+K+HEAFE +R
Sbjct: 2017 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDER 2059
Score = 414 bits (1063), Expect = e-115
Identities = 355/1628 (21%), Positives = 714/1628 (43%), Gaps = 104/1628 (6%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIASDENYK 73
I R+ V+ + EL RRQ+LE + Q ++ + W+ E K+ + S + K
Sbjct: 486 ITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGK 545
Query: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS----ETIRTRLMELHR 129
++ LQKH EA++ + + ++ + ++G + IR R+ +
Sbjct: 546 HLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEF 605
Query: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
++ L + E+ +L ++++L ++ E + WI +KE I++S++ G+DL V L
Sbjct: 606 CYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLS 665
Query: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
K F+ +M+ + + +I E+H E I+ + + W L+ L+ R+
Sbjct: 666 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 725
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
+L A+ + +F D D+ +W+ + ++++S D G D S Q+L++KH+ + ++A
Sbjct: 726 RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 785
Query: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
+ L +A L Q H + ++ + + ++++ L R L D+ L + ++
Sbjct: 786 TLDTLHEQASALPQEH-AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 844
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
W+ E + +N ++ + E + R + + E++ ++ + L+
Sbjct: 845 ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 904
Query: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM-SKQEA 488
+GH + E++ + L+ + EL + ++ + +Q ++ + + +W+ K +
Sbjct: 905 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 964
Query: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
+DLG+ L V AL +K E+ L A E K++ L + A KL + + + +R
Sbjct: 965 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1024
Query: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
+ + R A L ++ LQQF RD D+ +SW++ +T T A +D N
Sbjct: 1025 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS---RTQTAIASEDMPNTL 1081
Query: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE--------VAARMNEVISLW 660
+ +K + ++ ID E+ QK+ D+ + R+ + + W
Sbjct: 1082 TEAEKLLTQHENI---KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW 1138
Query: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
+L + E + L +++ QQF R+ + E +L E LA + L + KK
Sbjct: 1139 NELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQ 1198
Query: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
+ A++++I+ + R+ G+ +++ I++K +++ R+ +E +L
Sbjct: 1199 EDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRL 1258
Query: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
D+ LQ+ +D ++ WI EK + A + + + KHQA AE+A ++ +
Sbjct: 1259 KDNRDLQKFLQDCQELSLWINEK-MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWL 1317
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
+ ++G ++ E VK KL L++ WE L++ + Q L D+ +A+ +
Sbjct: 1318 DKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1377
Query: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
+ + W+ E + S DYGKD S LLKK + L + + I+ L+ QAQ+ Q+
Sbjct: 1378 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG 1437
Query: 961 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTL--LNSTNKD------WWKVEVNDR 1012
TD+ K L + + P + +K ++L ++ N+D W V +R
Sbjct: 1438 KSTDEVDSKRLTVQTKFMELLEP--LNERKHNLLASKEIHQFNRDVEDEILW----VGER 1491
Query: 1013 QGFVPAA-YVKKLDPAQSASRENLL---EEQGSIALRQEQIDNQTRITKEAGSVSL---- 1064
+ + L Q ++N E QG + + I ++ S+S
Sbjct: 1492 MPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR 1551
Query: 1065 -RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
R+ +++L+ L+E EKR LE++ + + +A E + W++E+E + SEE D
Sbjct: 1552 QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDE 1611
Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
+ + KK ++ ++ + ++K + L ++ E +++Q +V
Sbjct: 1612 QSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV-------- 1663
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
++ + L+ LAEER L H + + +R+ D
Sbjct: 1664 ----------------------------DKLYAGLKDLAEERRGKLDERHRLFQLNREVD 1695
Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALG-DKVNSLGETAERLIQS 1302
+ ++WI E+ + G D V LQ + F RD +G ++V+++ A+ LI S
Sbjct: 1696 DLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINS 1755
Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
A + E LN+AW+ L + D R L S++L +F D +++ I +
Sbjct: 1756 GHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQD-KHKK 1814
Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA--HGHYASPEIKQKL 1420
+EL +D E L H +I A + ++ +L A G A K++
Sbjct: 1815 LPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKREN 1874
Query: 1421 DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
++L+ ++ L+ +R ++D + + F WM + ++K + SV
Sbjct: 1875 EVLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VRDLMLWMEDVIRQIEAQEKPRDVSSV 1933
Query: 1481 EALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDI-------SSRRNEVLDRW 1533
E L+ H+ I+ + + L+A HYA +I + +R E++D+W
Sbjct: 1934 ELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKW 1993
Query: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
++ L + QFSRD EAW+ + S + ++ KL+
Sbjct: 1994 E-------DRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD-EVEKLI-- 2043
Query: 1594 HQKHQAFE 1601
++H+AFE
Sbjct: 2044 -KRHEAFE 2050
Score = 297 bits (760), Expect = 1e-79
Identities = 181/542 (33%), Positives = 293/542 (54%), Gaps = 5/542 (0%)
Query: 11 TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK-LQIASD 69
+AE I++R + + E + R ++LE+++R Q + DA E E W+ E+ L + S+
Sbjct: 1546 SAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE 1605
Query: 70 ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
E KD + L+KHQ E V+ + + +L +T ++++ H SE I R ++ +
Sbjct: 1606 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDK 1665
Query: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
+ L + E+ KL + +L Q RE +D+ WI ++E + S ELGQD EHV +LQ+
Sbjct: 1666 LYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE 1725
Query: 190 KFEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
+F EF D +ERV+ VN A +LI H + I +D +N AW L L R
Sbjct: 1726 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1785
Query: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
L + E+ +F D E I++K + + ++ GRD +V+ L R H E D+ AL
Sbjct: 1786 QILAASYELHKFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALG 1844
Query: 309 DKVKALCAEADRLQQSHPLS-ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFL 367
+V+ L +A RLQ ++ A IQ + E++ W+ + R RL D+ RF
Sbjct: 1845 TQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1904
Query: 368 ADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL 427
+ RDL W+ ++ I A E DV+ E L++ HQ K EIDA DSF + E G++L
Sbjct: 1905 SMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL 1964
Query: 428 LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487
LA HYAS+E++EKL L+E+R +++ WE R + +++ F RD + W+ QE
Sbjct: 1965 LARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQE 2024
Query: 488 AFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT-KLIQNNHYAMEDVAT 546
+L + ++G S+D VE L+K+HE FEKS + +E+ +AL+ T +L++ E+
Sbjct: 2025 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2084
Query: 547 RR 548
RR
Sbjct: 2085 RR 2086
Score = 247 bits (631), Expect = 9e-65
Identities = 179/742 (24%), Positives = 356/742 (47%), Gaps = 25/742 (3%)
Query: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIAS 68
ET ++E+ + + + + + Q+L D+ + + F + +L+KW+ + QI S
Sbjct: 1333 ETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQS 1392
Query: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE------TIRT 122
D+ KD T++ L+K Q E +++ I +L + EG E T++T
Sbjct: 1393 DDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT 1452
Query: 123 RLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLE 182
+ ME LLE + E+ LL ++++ Q+ R+ ED + W+ ++ + TS + G +L+
Sbjct: 1453 KFME-------LLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQ 1505
Query: 183 HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLK 241
V++L KK + Q ++ H+ R++++ + + ++ + E I+ + ++ W L
Sbjct: 1506 TVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLI 1565
Query: 242 GLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLE 301
+R +L A Q++ D E +W+ E+E M S++ +D S ++L+KH+ LE
Sbjct: 1566 EETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILE 1625
Query: 302 RDLAALEDKVKALCAEADRL-QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
+ + + V L + L SHP + +I +++ ++ + ++ LA ER +L++
Sbjct: 1626 QAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQSKVDKLYAGLKDLAEERRGKLDER 1684
Query: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEI-DAHEDSFKS 419
+RL + + DL W+ E + + + EL D L +R +E + + ++ +
Sbjct: 1685 HRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT 1744
Query: 420 ADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQV 479
+ L+ +GH + + E L+E A LLEL + R Q +L FY D +++
Sbjct: 1745 VNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1804
Query: 480 DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHY 539
+ + L E+LG ++VE L + H FE + A ++ L E A +L Y
Sbjct: 1805 FGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL--QAAY 1861
Query: 540 A---MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-T 595
A +D+ R + +L +L + RR +L D+ +FF +L W+ + ++
Sbjct: 1862 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI 1921
Query: 596 ATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNE 655
E +D S+++ + HQ +AE+ A + G+ L+ HYA +E+ ++ +
Sbjct: 1922 EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1981
Query: 656 VISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQN 715
+ K++++ E + LR + QF+R+ E WL E +L+S + G+ + V+
Sbjct: 1982 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEK 2041
Query: 716 LQKKHALLEADVAAHQDRIDGI 737
L K+H E A +R +
Sbjct: 2042 LIKRHEAFEKSAATWDERFSAL 2063
Score = 207 bits (526), Expect = 1e-52
Identities = 153/651 (23%), Positives = 302/651 (46%), Gaps = 11/651 (1%)
Query: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA-S 68
++ +++ +R V ++ E R+ L S F RD E+ W+ E++ +A S
Sbjct: 1438 KSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATS 1497
Query: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKL-DETGNLMISEGHFASETIRTRLMEL 127
++ + +Q ++K+Q + E+Q + I + + + N++ ++E IR RL +L
Sbjct: 1498 TDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADL 1557
Query: 128 HRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVL 187
+ W LL+E+ ++ +L +A + QY + + W++++E + SEE +D + +
Sbjct: 1558 KQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSM 1617
Query: 188 QKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQR 247
KK + + + + E V+++++ + L+ + HPE E I +Q +V+ + LK LA +R
Sbjct: 1618 LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEER 1677
Query: 248 QGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAAL 307
+GKL + + NR+VD+ WI E+E + S + G+D V L + RD +
Sbjct: 1678 RGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1737
Query: 308 -EDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRF 366
+++V + AD L S A I ++ L W + L R L SY L +F
Sbjct: 1738 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1797
Query: 367 LADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQA 426
D +++ + + + +EL D E L H + +I A + E
Sbjct: 1798 YHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR 1856
Query: 427 LLAAGHYA---SDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM 483
L AA YA +D+++++ + E +LL+ E RR + D F+ + WM
Sbjct: 1857 LQAA--YAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWM 1914
Query: 484 SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
+ ++ + SVE L+ H+ + + A+ + T E L+ HYA E+
Sbjct: 1915 EDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEE 1974
Query: 544 VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW-VNEKMKTATDEAYK 602
+ + L +R + ++ R L + QF RD+ ++W + ++ ++ E +
Sbjct: 1975 IKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQ 2034
Query: 603 DPSNLQGKVQKHQAFEAELSANQSRIDALEK-AGQKLIDVNHYAKDEVAAR 652
++ +++H+AFE + R ALE+ +L++V ++E R
Sbjct: 2035 SVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKR 2085
Score = 98.2 bits (243), Expect = 9e-20
Identities = 128/611 (20%), Positives = 244/611 (39%), Gaps = 86/611 (14%)
Query: 1751 FQKIKSMAASRRA------KLNESHRLHQFFRDM-DDEESWIKEKKLLVGSEDYGRDLTG 1803
F K+K++A + E+ ++ + + + D WI++ +++ + + L G
Sbjct: 264 FSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG 323
Query: 1804 VQ----------------------NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTI 1841
VQ NL +++++ A+ + + GK +SD N
Sbjct: 324 VQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE-GKLISDIN-- 380
Query: 1842 GKEEIQQRLAQFVEHWKELKQLAAARGQRL-EESLEY--QQFVANVEEEEAWINEKMTLV 1898
+ +RL + EH +EL A R + + +E LE ++F E W++E LV
Sbjct: 381 ---KAWERLEK-AEHEREL----ALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLV 432
Query: 1899 ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG 1958
+ +++G L A++ KKHEA ETD +++RV V ++L +N H + I+++
Sbjct: 433 SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 492
Query: 1959 LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQT 2018
+ L + R+ +L+ N + + + W+ E + + + DYG+ L V+
Sbjct: 493 VIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVED 552
Query: 2019 LLTKQETFDA--GLQAFQQEGI-ANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLA 2075
LL K +A G+QA + G+ A+ K + I R A + + +L
Sbjct: 553 LLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ 612
Query: 2076 NSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALR 2135
+A R+ +L E+ R++ F A++ W E+ L+ L + L
Sbjct: 613 LAAERRARLEES----RRLWKFFWEMAEE----EGWIREKEKILSSDDYGKDLTSVMRLL 664
Query: 2136 EAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERE 2195
H AF +S F Q + + + + + + E W NL+++ R+
Sbjct: 665 SKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRK 724
Query: 2196 LELQKEQRRQEENDKLRQEFAQHANAFHQWIQE----------------TRTYLLDGSCM 2239
L E L +F A+ W+ + T++ + +
Sbjct: 725 KRL--------EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDV 776
Query: 2240 VEESG-------TLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHST 2292
EE TL Q A ++H E +R +L IE+ + E L K T
Sbjct: 777 AEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL-RKQALQDT 835
Query: 2293 VGLAQQWDQLD 2303
+ L + + + D
Sbjct: 836 LALYKMFSEAD 846
Score = 47.8 bits (112), Expect = 1e-04
Identities = 61/296 (20%), Positives = 119/296 (40%), Gaps = 18/296 (6%)
Query: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
A Q G+ + +D ++ H K+I + +S++ A A K++ + +
Sbjct: 228 AEQHLGLTKLLDPED--ISVDHPDEKSIITYVVTYYHYFSKMKA-LAVEGKRIGKVLDNA 284
Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQ-A 2150
+ E + + AS W E L + NSL ++ +A + +R+ +
Sbjct: 285 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 344
Query: 2151 DFNQLAELDRQIKSFRVASNPYTWFTMEA-----LEETWRNLQKIIKERELELQKEQRRQ 2205
+ L L I+S A+N + E + + W L+K EREL L+ E RQ
Sbjct: 345 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 404
Query: 2206 EENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ----EIR 2261
E+ ++L + F + A W+ E + + + G +EA +KH+ +I
Sbjct: 405 EKLEQLARRFDRKAAMRETWLSENQRLVSQ-----DNFGFDLPAVEAATKKHEAIETDIA 459
Query: 2262 AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQI 2317
A +++ + + +E D K + + W+ L +L + LE +
Sbjct: 460 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNL 515
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 609 bits (1570), Expect = e-173
Identities = 402/1417 (28%), Positives = 707/1417 (49%), Gaps = 78/1417 (5%)
Query: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
+E I+ER + +++ ++LS +R+++LE++ FQ DA++++ W+ + L+I S +
Sbjct: 712 SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
Query: 72 Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
D + Q ++KH+ E+ + L E + + E H S +R RL + +
Sbjct: 772 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEER 830
Query: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
++ + E R + L L + E + WI++KE + + ++ + LE +EV+Q +
Sbjct: 831 YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 890
Query: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK 250
FE + +M RV VNQ A +L+ HP E+ IK +QD++N W + + L +++
Sbjct: 891 FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 950
Query: 251 LFGAAEVQRFNRDVDETISWIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALED 309
L A +Q ++ + +ET SWI+EK +++ S D G DLA V AL RK G+ERDL A+E
Sbjct: 951 LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 1010
Query: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
K+ L EA++L+ HP A I + E+ WE+++T R A L ++ +LQ+FL D
Sbjct: 1011 KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRD 1070
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
D SW++ + I ++++ + + AE LL +H+ K EID +E+ ++ + G+ +
Sbjct: 1071 LDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ 1130
Query: 430 AGHYASDE-VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
A +R++L L L ++WE R+ Q Q F RDT+Q + +++ QE
Sbjct: 1131 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1190
Query: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
L + ++ +L+ EA +KK EDF ++ A EEKI A+ E +L+ + + + + +
Sbjct: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250
Query: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
D++ R E A +L D+ LQ+F +D EL W+NEKM TA D +Y + NL
Sbjct: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310
Query: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668
K KHQAF AEL++N+ +D +EK G +LI + V ++ + +W+ L T+
Sbjct: 1311 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1370
Query: 669 LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728
K +L +AN+ + F ++ D++ WL+ +E + SDDYGKDLT+V L KK +LE +
Sbjct: 1371 TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQME 1430
Query: 729 AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
+ I+ + QA+ G + + K+ + ++ L EP+ RK L S + Q
Sbjct: 1431 VRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ 1489
Query: 789 LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG- 847
RDVEDE W+ E+ P+A ST+ G +L VQ L+KK+Q LQ EI GH+PRI + ++
Sbjct: 1490 FNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQ 1549
Query: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
N + + +AE ++ +L +L Q W L + +R + LE++ +AQQY+ DA EAE+WM
Sbjct: 1550 NIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1609
Query: 908 EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
E+E + S + KDE SA ++LKKH+ L + Y ++ L + +++ P +
Sbjct: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669
Query: 968 G------KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYV 1021
+L L D E+ R + + L LN EV+D + ++ V
Sbjct: 1670 SMRQSKVDKLYAGLKDLAEE--RRGKLDERHRLFQLNR--------EVDDLEQWIAEREV 1719
Query: 1022 --KKLDPAQSASRENLLEEQ--------GSIALRQEQIDNQTRITKE--------AGSVS 1063
+ Q +L+E+ G+I QE++D + E A +++
Sbjct: 1720 VAGSHELGQDYEHVTMLQERFREFARDTGNIG--QERVDTVNHLADELINSGHSDAATIA 1777
Query: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
+ E + LLEL + R +L S + + +A E+ I +K L EE+G D
Sbjct: 1778 EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQ 1836
Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
VE LQ+ F+ D++A ++++ + + A L++ ++ +Q++E
Sbjct: 1837 NTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQA-AYAGDKADDIQKRE--------- 1886
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
E+ E W+SL E R L + RF
Sbjct: 1887 -------------------------NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1921
Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
+ W+E+ + + D++SV+ L H+G + ++ A D + E + L+
Sbjct: 1922 DLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981
Query: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
++E+++EK +L + + + + R L ++ +F D +W+ G +S
Sbjct: 1982 HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLS 2041
Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
S E+ + V E L++RH+ F A E+
Sbjct: 2042 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALER 2078
Score = 565 bits (1455), Expect = e-160
Identities = 403/1511 (26%), Positives = 737/1511 (48%), Gaps = 84/1511 (5%)
Query: 26 YHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDENY-KDPTNLQGKLQ 83
Y +L+ RR +LE+S R ++FF AEE E WI+EK +I S ++Y KD T++ L
Sbjct: 620 YQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEKILSSDDYGKDLTSVMRLLS 678
Query: 84 KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGI 143
KH+AFE E+ SG + + G MI+E HF SE IR R++ + QW L + +
Sbjct: 679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738
Query: 144 KLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
+L +A L Q+ + +D+ W+ D IV+S ++G D + L KK ++ ++A +
Sbjct: 739 RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798
Query: 204 RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
++ +++ A+ L QE H E ++ + + ++ + L R+ L + + +
Sbjct: 799 TLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857
Query: 264 VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
D WI EKEQ + + L ++ + + E LE ++ +V + A +L
Sbjct: 858 ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 917
Query: 324 SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEM-KA 382
S S +I+ ++++L T W Q R L + L + +Q + + + SW+ E K
Sbjct: 918 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 977
Query: 383 LINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKL 442
+ + +L +D+AG AL + + ++ A E + + L + + + +L
Sbjct: 978 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1037
Query: 443 TVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSV 502
+S+ + + R + LQ F RD + +W+S+ + + +ED+ ++L
Sbjct: 1038 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEA 1097
Query: 503 EALLKKHEDFEKSLSAQEE---KITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALH 559
E LL +HE+ + + EE K+ + E T+ + Y + R AL + N LH
Sbjct: 1098 EKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMF--LRQRLQALDTGWNELH 1155
Query: 560 ERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGK---VQKHQA 616
+ R+ L+ S QQF RD+ + ++++N + P+ L+G ++K +
Sbjct: 1156 KMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEM--PTTLEGAEAAIKKQED 1213
Query: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
F + AN+ +I+A+ + G++L+ + D + +++ + +K E ++L++
Sbjct: 1214 FMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKD 1273
Query: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEADVAAHQDRID 735
Q+F ++ +++ LW+ E L + D D N+ + KH A++A++++ +D
Sbjct: 1274 NRDLQKFLQDCQELSLWINEKM--LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLD 1331
Query: 736 GITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED 795
I + Q +K+K L +E L+ + Q+L D+ + + + D
Sbjct: 1332 KIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCAD 1391
Query: 796 EETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGH 855
+ W+ E S + GKDL V LLKK Q L+ ++ + I+ + + A+ +EG
Sbjct: 1392 LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1451
Query: 856 FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGS 915
+ ++V +K + K+ L ++R+ +L S + Q+ D + W+ E+ P+ S
Sbjct: 1452 -STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATS 1510
Query: 916 TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC------------RQQVAPT 963
TD+G + + + L+KK++ L ++ + I + E++Q+ RQ++A
Sbjct: 1511 TDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADL 1570
Query: 964 DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKK 1023
K+L L + EK R + ++ + W E + K
Sbjct: 1571 -----KQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE--QELYMMSEEKAKD 1623
Query: 1024 LDPAQSASRENLLEEQG--SIALRQEQIDNQTRIT-----KEAGSVSLRMKQVEELYHSL 1076
A S +++ + EQ A Q+ +R E+ +S+R +V++LY L
Sbjct: 1624 EQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGL 1683
Query: 1077 LELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDF 1136
+L E+R+G L++ + F L RE ++L+QWI E+E S E+G D E V +LQ++F +F
Sbjct: 1684 KDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREF 1743
Query: 1137 QKDL-KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSA 1195
+D + R+ +N +A++L + G +D+ T + WK
Sbjct: 1744 ARDTGNIGQERVDTVNHLADELINSG---------------------HSDAATIAEWKDG 1782
Query: 1196 RLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQA 1255
LNE W L +L + R+Q+L +++E+ +F+ DA E I++K++
Sbjct: 1783 ---------------LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKK 1827
Query: 1256 LNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKC 1314
L + G D +V+ LQR H FE D+ ALG +V L E A RL ++ + A+D+Q++
Sbjct: 1828 L-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRE 1886
Query: 1315 TELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGA 1374
E+ +AW SL + R+ +L D+ D RF S RDLM W+ + + + E +DV+
Sbjct: 1887 NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1946
Query: 1375 EALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAW 1434
E L+ HQ + EIDAR +F + G+ LLA HYAS EIK+KL L ++R ++ W
Sbjct: 1947 ELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKW 2006
Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
R L LE+ F RD AE W+ +E +L++ + G S+D VE LIK+HE F+K+
Sbjct: 2007 EDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSA 2066
Query: 1495 NVQEEKIAALQ 1505
+E+ +AL+
Sbjct: 2067 ATWDERFSALE 2077
Score = 527 bits (1357), Expect = e-149
Identities = 409/1739 (23%), Positives = 806/1739 (46%), Gaps = 117/1739 (6%)
Query: 557 ALHERAMRRRAQLADSFHLQQFFRDSDEL----KSWVNEKMKTATDEAYK-DPSNLQGKV 611
A HER + R +L L+Q R D ++W++E + + + + D ++
Sbjct: 402 AEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT 461
Query: 612 QKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKG 671
+KH+A E +++A + R+ A+ ++L N++ + AR + VI LW+ LLE +
Sbjct: 462 KKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARR 521
Query: 672 IKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+L Q+ + + I W+ E++ + S DYGK L V++L +KH L+EAD+
Sbjct: 522 QRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQA 581
Query: 732 DRIDGITIQARQFQDAGH----FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
+R+ G+ A++F G D + I+ + + Y+ L + R+ +L +S RL
Sbjct: 582 ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLW 641
Query: 788 QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
+ F ++ +EE WIREKE I +S + GKDL V LL KH+A + E++G + ++G
Sbjct: 642 KFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 701
Query: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
M+ E HF +E ++ ++ + ++W L+ ++ R++ LE++ Q+ ADA++ ++WM
Sbjct: 702 EDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWML 761
Query: 908 EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
+ IV S+D G DE S ++L+KKH+ + +++ Y ++ L EQA + Q+ A + D
Sbjct: 762 DILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVR 821
Query: 968 GKELVLALYDYQEKSPREVTMKK----GDILTLLNS-TNKDWWKVEVNDRQGFVPAAYV- 1021
G+ L+ + + K E+T + D L L + D ++ +++++ ++ +
Sbjct: 822 GR---LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIP 878
Query: 1022 KKLDPAQSASR--ENLLEEQGSIALRQEQIDNQTRITKEAG-----SVSLRMKQVEELYH 1074
+KL+ + E+L E + A R ++ R +G + + ++ +
Sbjct: 879 EKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWS 938
Query: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS-EEVGADLEQVEVLQKKF 1133
EL +++K L + E NE + WI EK + S +++G DL V LQ+K
Sbjct: 939 QFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL 998
Query: 1134 DDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWK 1193
++DL A E++L D+ K AE LESE ++ QA+
Sbjct: 999 TGMERDLVAIEAKLSDLQKEAEKLESE--HPDQAQAI----------------------- 1033
Query: 1194 SARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKN 1253
+ + E+++ W ++ + R LG A ++Q+F RD D+ + W+
Sbjct: 1034 -----------LSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQ 1082
Query: 1254 QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESA-EDLQE 1312
A+ +++ + L + L +HE + ++ + + + E + Q ++ L++
Sbjct: 1083 TAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQ 1142
Query: 1313 KCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVT 1372
+ L+ W+ L K + R+ L SH Q+FL D + +++N +++ E+ +
Sbjct: 1143 RLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLE 1202
Query: 1373 GAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEK 1432
GAEA +++ ++ T +DA A + G++L++ G+ S I++K+D +D +
Sbjct: 1203 GAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE 1262
Query: 1433 AWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKG-DSLDSVEALIKKHEDFD 1491
+ M L +LQ F +DC++ W+ E L +D D ++ + KH+ F
Sbjct: 1263 TASELLMRLKDNRDLQKFLQDCQELSLWI--NEKMLTAQDMSYDEARNLHSKWLKHQAFM 1320
Query: 1492 KAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQ 1551
+ +E + ++ QLI+ + + + + W L++ K +L ++
Sbjct: 1321 AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN 1380
Query: 1552 TLQQFSRDVDEIEAWI-SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADR 1610
+ F++ +++ W+ + Q SD+ KD T++ + LL +K Q E ++
Sbjct: 1381 KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNI--LL---KKQQMLENQMEVRKKE 1435
Query: 1611 IRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNT 1670
I + +L + G S D V ++ + ++ L++ E+ L + + FN
Sbjct: 1436 IEELQSQAQALSQEGK---STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNR 1492
Query: 1671 GIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLM 1730
++D W+ E L S D+G +L +V L+KK+Q L+ +I H+ R+ D+ ++ +++
Sbjct: 1493 DVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIV 1552
Query: 1731 T-SSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKK 1789
T SS+ ++ + + + + R +L E+HR Q++ D + E+W+ E++
Sbjct: 1553 TDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQE 1612
Query: 1790 LLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQR 1849
L + SE+ +D ++ KKH+ LE + + + + T + L D+ E I R
Sbjct: 1613 LYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMR 1672
Query: 1850 LAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAA 1909
++ + + LK LA R +L+E Q V++ E WI E+ + S + G
Sbjct: 1673 QSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEH 1732
Query: 1910 IQGLLKKHEAFETDF-TVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEK 1968
+ L ++ F D + ++RV+ V +LI + I+ GLN +DL +
Sbjct: 1733 VTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLE 1792
Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
R L + +F A + I +K L ++ GRD ++V+TL TF+
Sbjct: 1793 LIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEH 1851
Query: 2029 GLQAFQQEGIANITALKDQL--LAAKHVQSKA--IEARHASLMKRWSQLLANSAARKKKL 2084
+QA + + L++ L A + KA I+ R +++ W LL +R+ +L
Sbjct: 1852 DIQALGTQ----VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRL 1907
Query: 2085 LEAQSHFR---KVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAF 2141
++ FR V DL L W E+ + + + ++ L H
Sbjct: 1908 VDTGDKFRFFSMVRDLML-----------WMEDVIRQIEAQEKPRDVSSVELLMNNHQGI 1956
Query: 2142 RSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKE 2201
++ + + F EL + + +A Y A EE L ++ ++R+ + K
Sbjct: 1957 KAEIDARNDSFTTCIELGKSL----LARKHY------ASEEIKEKLLQLTEKRKEMIDKW 2006
Query: 2202 QRRQEENDKLRQ--EFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
+ R E + + +F++ A+ W+ YL E G ++E ++H+
Sbjct: 2007 EDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSS-----REIGQSVDEVEKLIKRHE 2060
Score = 519 bits (1337), Expect = e-146
Identities = 394/1716 (22%), Positives = 798/1716 (46%), Gaps = 82/1716 (4%)
Query: 35 LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYK-DPTNLQGKLQKHQAFEAEVQ 93
+R++KLE R F R A E W+ E ++ S +N+ D ++ +KH+A E ++
Sbjct: 415 IRQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIA 472
Query: 94 ANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ 153
A + + + +E + + I R + R WE LLE +R + +L L +
Sbjct: 473 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 532
Query: 154 YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAA 213
+E +MDW+++ + +V S++ G+ L VE L +K + D+ ERV VN A
Sbjct: 533 IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQ 592
Query: 214 KLIQEQHP----EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS 269
K + + ++I+ + + +Q L LA +R+ +L + + +F ++ E
Sbjct: 593 KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG 652
Query: 270 WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSA 329
WI+EKE++++SDD+G+DL SV LL KH E +++ + E + + +
Sbjct: 653 WIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGS 712
Query: 330 TQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADEL 389
+I+ + + W + L+A R RL ++ L +F AD D+ +W+ ++ ++++ ++
Sbjct: 713 EKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV 772
Query: 390 ASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEER 449
D ++L+ +H++ EI + + + E AL H S +VR +L+ + E
Sbjct: 773 GHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERY 831
Query: 450 AALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKH 509
+ EL LR+Q + + L + + + + W+ ++E +L N + + L+ +E + +
Sbjct: 832 KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 891
Query: 510 EDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQL 569
E E ++ Q ++ +++ A +L+ + H + +++ ++D L +R + E R++ L
Sbjct: 892 ESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL 951
Query: 570 ADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKDPSNLQGKVQKHQAFEAELSANQSR 627
+ +Q + + +E KSW+ EK K +T + D + + +K E +L A +++
Sbjct: 952 LSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011
Query: 628 IDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV 687
+ L+K +KL + + +R+ E+ +W+++ + + L EA++ QQF R++
Sbjct: 1012 LSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDL 1071
Query: 688 EDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
+D + WL + +AS+D LT + L +H ++ ++ +++ +
Sbjct: 1072 DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ- 1130
Query: 748 GHFDAEN--IKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
G DA+ ++++ +AL + L + R+ L+ S QQ RD + E ++ +E
Sbjct: 1131 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1190
Query: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
+ A T L G + +KK + + +E +I AV + G +V +G+ ++ ++ K+
Sbjct: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250
Query: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA 925
++ + + AS+ L+D+ Q++ D E W+ EK Y + +
Sbjct: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310
Query: 926 EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDY------- 978
LK H+A M++L++ + + ++ + P + KE + L+
Sbjct: 1311 SKWLK-HQAFMAELASNKEWLDKIEKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLEST 1368
Query: 979 -QEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSA-SRENLL 1036
Q K+ R K ++ T + + D W + + Y K L ++ +L
Sbjct: 1369 TQTKAQRLFDANKAELFTQ-SCADLDKWLHGLESQ--IQSDDYGKDLTSVNILLKKQQML 1425
Query: 1037 EEQGSIALRQ-EQIDNQTRITKEAGS----VSLRMKQVEELYHSLLELGEKRKGMLEKSC 1091
E Q + ++ E++ +Q + + G V + V+ + LLE +RK L S
Sbjct: 1426 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASK 1485
Query: 1092 KKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDIN 1151
+ R+ + W+ E+ TS + G +L+ V++L KK QK+++ ++ R+ DI
Sbjct: 1486 EIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1545
Query: 1152 KVAEDL--ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIK 1209
+ ++++ +S L AE A++Q+ +
Sbjct: 1546 ERSQNIVTDSSSLSAE---AIRQR----------------------------------LA 1568
Query: 1210 ELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQ 1269
+L + W L + E+R + L AH Q+++ DA E + W+ E+ + ++ D S
Sbjct: 1569 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1628
Query: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELNQAWSSLGKRA 1328
++ +KH+ E+ + + V+ L +T+ L+ SHPES E + + +++++ ++ L A
Sbjct: 1629 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPES-ERISMRQSKVDKLYAGLKDLA 1687
Query: 1329 DQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEI 1388
++R+ KL + H L + + DL WI + S EL +D L ER +E +
Sbjct: 1688 EERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDT 1747
Query: 1389 -DARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLEL 1447
+ +L+ GH + I + D L++ ADL + R +L EL
Sbjct: 1748 GNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYEL 1807
Query: 1448 QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAF 1507
F+ D ++ + + L E+ G ++VE L + H F+ I ++ LQ
Sbjct: 1808 HKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQED 1866
Query: 1508 ADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566
A +L AA K D I R NEVL+ W+ L +R +L ++ +F V ++ W
Sbjct: 1867 AARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLW 1926
Query: 1567 ISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626
+ + ++ E+ + P ++ +LL + HQ +AE+ A D I++G SL+ R
Sbjct: 1927 MEDVIRQI--EAQEKPRDVSSVELLMNN--HQGIKAEIDARNDSFTTCIELGKSLLARKH 1982
Query: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686
A E +K +L L ++ + ++ K ++ + L+ + F+ + WL E L
Sbjct: 1983 YASEE--IKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2040
Query: 1687 ASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1722
+S + G+ + V L+K+H+ E + ++R L
Sbjct: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL 2076
Score = 516 bits (1329), Expect = e-145
Identities = 428/1900 (22%), Positives = 854/1900 (44%), Gaps = 139/1900 (7%)
Query: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQEH-----------KGEIDAHEDSFKS- 419
DL W+ + ++N + A+ + G + L + KG ++ + +S
Sbjct: 313 DLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSK 372
Query: 420 --ADESGQALLAAGHYASD--EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
A+ + G SD + E+L ER L +R+++ EQ + F R
Sbjct: 373 MRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLA--RRFDRK 430
Query: 476 TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
+ W+S+ + + ++ G L +VEA KKHE E ++A EE++ A+ A +L
Sbjct: 431 AAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEA 490
Query: 536 NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT 595
N++ ++ + R+D ++ L E RR +L + LQ+ F++ + W++E
Sbjct: 491 ENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVL 550
Query: 596 ATDEAY-KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAK----DEVA 650
+ Y K ++ +QKH EA++ R+ + + QK K +
Sbjct: 551 VLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR 610
Query: 651 ARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDL 710
R+ + +++L + + +L E+ + +F + + E W+ E E L+SDDYGKDL
Sbjct: 611 DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 670
Query: 711 TNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALK 770
T+V L KH E +++ + + HF +E I+++ + ++ L+
Sbjct: 671 TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLE 730
Query: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830
+ RK++L ++ L Q D +D + W+ + I +S++ G D Q+L+KKH+ +
Sbjct: 731 QLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVA 790
Query: 831 AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890
EIA + P + + ++ +A+ +E H + DV+ +L + ++++ + R+Q L+D+L
Sbjct: 791 EEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 849
Query: 891 QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
+ F++A+ E W+ EKE + + + + E + + E+L +++ S + +
Sbjct: 850 ALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 909
Query: 951 EQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVN 1010
+ A+ P++ E K L + V KK +L+ L+ N + +E N
Sbjct: 910 QIARQLMHSGHPSEKEI-KAQQDKLNTRWSQFRELVDRKKDALLSALSIQN---YHLECN 965
Query: 1011 DRQGFVPAAYVKKLDPAQ----------SASRENLLEEQGSIALRQEQIDNQTRITK--- 1057
+ + ++ K ++ Q + R+ E+ +A+ + D Q K
Sbjct: 966 ETKSWIREK-TKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLES 1024
Query: 1058 ----EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
+A ++ R+ ++ +++ + + R+ L ++ K R+ ++ Q W++ + A
Sbjct: 1025 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTA 1084
Query: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
+ SE++ L + E L L +E+ +I+ ED + M E V Q
Sbjct: 1085 IASEDMPNTLTEAEKL----------LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1134
Query: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
Y + + ++ L+ W L ++ E R LL +H
Sbjct: 1135 AQYMFLRQ-------------------------RLQALDTGWNELHKMWENRQNLLSQSH 1169
Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
Q+F RD + + ++ + L L +A +K E F + A +K+N++
Sbjct: 1170 AYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVV 1229
Query: 1294 ETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMS 1353
ET RL+ +++ +QEK ++ + A + +L D+ DLQ+FL D ++L
Sbjct: 1230 ETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSL 1289
Query: 1354 WINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYAS 1413
WIN + L + D + + +HQ E+ + E+ G QL++
Sbjct: 1290 WINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETE 1348
Query: 1414 PEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK 1473
+K+KL L + LE + L + +LF + C + W+ E+ + ++D
Sbjct: 1349 AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDY 1408
Query: 1474 GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRW 1533
G L SV L+KK + + + V++++I LQ+ A L G + ++ S+R V ++
Sbjct: 1409 GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKF 1467
Query: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
L + E++ L S+ + QF+RDV++ W+ E++ A+ + N+Q +LL K
Sbjct: 1468 MELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH--NLQTVQLLIK 1525
Query: 1594 HQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSA 1653
K+Q + E+ + RI + + +++ + +E A++ RLA L W L++++
Sbjct: 1526 --KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE-AIRQRLADLKQLWGLLIEETE 1582
Query: 1654 EKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADIS 1713
++ ++L+EA++ Q + + + W+SE E + SE+ KD S ++LKKHQ+LE +
Sbjct: 1583 KRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVE 1642
Query: 1714 AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ 1773
+ + + L+ + +L+ S ++ ++ ++ ++ + +K +A RR KL+E HRL Q
Sbjct: 1643 DYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQ 1702
Query: 1774 FFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAI-QGVLDTG 1832
R++DD E WI E++++ GS + G+D V L+++ + E A I Q +DT
Sbjct: 1703 LNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR----EFARDTGNIGQERVDTV 1758
Query: 1833 KKLSDDNTIGKEEIQQRLAQFV----EHWKELKQLAAARGQRLEESLEYQQFVANVEEEE 1888
L+D+ +A++ E W +L +L R Q L S E +F + +E
Sbjct: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIF 1818
Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHH 1948
I +K + E+ G ++ L + H FE D +V + + L
Sbjct: 1819 GRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGD 1877
Query: 1949 EENISSKMKG--LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKT 2006
+ + K + L S L+ ++R +D F F+ D++ W+ + ++
Sbjct: 1878 KADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM-LWMEDVIRQIEA 1936
Query: 2007 DDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASL 2066
+ RD+SSV+ L+ + A + A + + L LLA KH S+ I+ + L
Sbjct: 1937 QEKPRDVSSVELLMNNHQGIKAEIDA-RNDSFTTCIELGKSLLARKHYASEEIKEKLLQL 1995
Query: 2067 MKRWSQLLANSAARKKKL-LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRC 2125
++ +++ R + L L + H F++ AS +W E L+
Sbjct: 1996 TEKRKEMIDKWEDRWEWLRLILEVH---------QFSRDASVAEAWLLGQEPYLSSREIG 2046
Query: 2126 NSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR 2185
S++E++ L + H+AF S ++ F+ L L T+E LE
Sbjct: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLT----------------TLELLE---- 2086
Query: 2186 NLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW 2225
R + ++E++R+ + + + ++ A + QW
Sbjct: 2087 -------VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQW 2119
Score = 509 bits (1310), Expect = e-143
Identities = 414/1901 (21%), Positives = 839/1901 (44%), Gaps = 122/1901 (6%)
Query: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQ--RQGKLFGAA-----EVQRFNRDVDETI 268
I HP+E+ I T + ++K LA++ R GK+ A ++++ + +
Sbjct: 256 ISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL 315
Query: 269 SWIKEKEQLMASDDFGRDLASVQALLRKHE---------------GLERDLAALEDKVKA 313
WI++ ++ + F L VQ L+ LE L ++ K++A
Sbjct: 316 EWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRA 375
Query: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ--------R 365
+ ++ +S ++ WE++ ER L + Q R
Sbjct: 376 NNQKVYMPREGKLIS---------DINKAWERLEKAEHERELALRNELIRQEKLEQLARR 426
Query: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
F +W++E + L++ D D+ EA +H+ + +I A+E+ ++ +
Sbjct: 427 FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR 486
Query: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
L A ++ + + + LLEL RRQ+ E + LQ +++ + +WM +
Sbjct: 487 ELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDE 546
Query: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH-YAMEDV 544
+ +L++D G L VE LL+KH E + Q E++ ++ A K + Y D
Sbjct: 547 MKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDP 606
Query: 545 ATRRDALLSRR---NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY 601
RD + L + A RRA+L +S L +FF + E + W+ EK K + + Y
Sbjct: 607 QVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDY 666
Query: 602 -KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
KD +++ + KH+AFE E+S + K G+ +I H+ +++ R+ + W
Sbjct: 667 GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQW 726
Query: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
L + + ++ +L EA+ QF + +DI+ W+ ++ ++S D G D + Q+L KKH
Sbjct: 727 ANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH 786
Query: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
+ ++A ++ +D + QA H ++ +++ + + RY+ + E RKQ L
Sbjct: 787 KDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQAL 845
Query: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
D+L L ++F + + E WI EKE + + L ++ + + ++L+ E+ R+
Sbjct: 846 QDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRV 905
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
V Q ++ GH + +++KA+ +LN +W + +++ L +L Q Y + N
Sbjct: 906 AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECN 965
Query: 901 EAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
E +SW+REK ++ ST D G D AL +K + DL A + + L+++A+ +
Sbjct: 966 ETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE 1025
Query: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVP-- 1017
+ + ++ L + + T K +L ++ + +++D Q ++
Sbjct: 1026 ----HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1081
Query: 1018 -AAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL------------ 1064
A + P E LL + +I + + + ++ G +
Sbjct: 1082 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
Query: 1065 -RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
R++ ++ ++ L ++ E R+ +L +S R+ + + ++N +E L E+ L
Sbjct: 1142 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTL 1201
Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
E E KK +DF + ANE ++ + + L S+G + + + QE
Sbjct: 1202 EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDG----NINSDRIQE--------- 1248
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
+ +++R R ++ A E L ++Q+F +D
Sbjct: 1249 -----------------------KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ 1285
Query: 1244 ETKEWIEEKNQALNTDNYGHDLA-SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
E WI EK L + +D A ++ + KH+ F +LA+ + ++ + + +LI
Sbjct: 1286 ELSLWINEK--MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE 1343
Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
PE+ ++EK T L++ W L + +L D++ + F DL W++G+ +
Sbjct: 1344 KPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQI 1403
Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422
SD+ KD+T LL++ Q +++ R + + Q L G ++ E+ K
Sbjct: 1404 QSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLT 1462
Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482
+ + +L + +R+ L E+ F+RD E W+ R + D G +L +V+
Sbjct: 1463 VQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQL 1522
Query: 1483 LIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQMI 1541
LIKK++ K I + +I + + ++ + I R ++ W L +
Sbjct: 1523 LIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETE 1582
Query: 1542 EKRSKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQLSKLLSKHQKHQAF 1600
++ +L E+ QQ+ D E EAW+SE+ L S+E KD + +S +KHQ
Sbjct: 1583 KRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSA-----VSMLKKHQIL 1637
Query: 1601 EAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLK 1660
E + A+ + + +L+ + + R + + + L + E+ KL
Sbjct: 1638 EQAVEDYAETVHQLSKTSRALVADSH--PESERISMRQSKVDKLYAGLKDLAEERRGKLD 1695
Query: 1661 EANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRL 1719
E ++ N + D + W++E E + S + G+D V L ++ + D + ++R+
Sbjct: 1696 ERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERV 1755
Query: 1720 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMD 1779
+N AD L+ S D + + + +D +N + + + +R L S+ LH+F+ D
Sbjct: 1756 DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAK 1815
Query: 1780 DEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN 1839
+ I++K + E+ GRD V+ L++ H E ++ A ++ + + +L
Sbjct: 1816 EIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAY 1874
Query: 1840 TIGK-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLV 1898
K ++IQ+R + +E WK L +R RL ++ + +F + V + W+ + + +
Sbjct: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI 1934
Query: 1899 ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG 1958
+++ +++++ L+ H+ + + D G+ L+ + ++ E I K+
Sbjct: 1935 EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1994
Query: 1959 LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQT 2018
L K ++ R L QF+ A V E+W+ +E L + + G+ + V+
Sbjct: 1995 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEK 2054
Query: 2019 LLTKQETFDAGLQAFQQ--EGIANITALKDQLLAAKHVQSK 2057
L+ + E F+ + + + +T L +LL + Q +
Sbjct: 2055 LIKRHEAFEKSAATWDERFSALERLTTL--ELLEVRRQQEE 2093
Score = 498 bits (1283), Expect = e-140
Identities = 431/1843 (23%), Positives = 824/1843 (44%), Gaps = 126/1843 (6%)
Query: 146 LQAQKLVQ-YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQT--DMAAHE 202
++ +K+++ Y D+++WI I+ + + L V+ + F ++T
Sbjct: 298 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 357
Query: 203 ERVN-EVNQFAAKLIQEQHPEEELIKTKQ---DEVNAAWQRL------KGLALQ----RQ 248
E+ N EV F + + ++ + + ++N AW+RL + LAL+ RQ
Sbjct: 358 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 417
Query: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
KL A +RF+R +W+ E ++L++ D+FG DL +V+A +KHE +E D+AA E
Sbjct: 418 EKLEQLA--RRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYE 475
Query: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
++V+A+ A A L+ + +I +++ +I WE + L R RL + LQ+
Sbjct: 476 ERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQ 535
Query: 369 DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ--A 426
+ + W+ EMK L+ + + + G E LL +H + +I + + + S Q A
Sbjct: 536 EMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFA 595
Query: 427 LLAAGHYASDE--VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
G+ D +R+++ + L +L RR + E+ L F+ + + + W+
Sbjct: 596 TDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIR 655
Query: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
++E L ++D G L SV LL KH FE +S + + +I H+ E +
Sbjct: 656 EKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKI 715
Query: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKD 603
R + + L + + R+ +L ++ L QF D+D++ +W+ + +K ++ + D
Sbjct: 716 RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD 775
Query: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
+ Q V+KH+ E++ + +D L + L H +V R++ + +K++
Sbjct: 776 EYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEV 834
Query: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
E T L+ L++ + + ELW+ E E L + + L +++ +Q + L
Sbjct: 835 AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESL 894
Query: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
E ++ R+ + ARQ +GH + IK +Q+ L R+ +E + +K L +
Sbjct: 895 EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSA 954
Query: 784 LRLQQLFRDVEDEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
L +Q + + ++WIREK + ST + G DL GV L +K ++ ++ E ++
Sbjct: 955 LSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSD 1014
Query: 843 VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
+ ++ + E A+ + ++L E++ WE +K R L ++ + QQ+ D ++
Sbjct: 1015 LQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDF 1074
Query: 903 ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE----------- 951
+SW+ + + S D AE LL +HE + +++ Y Q +R+
Sbjct: 1075 QSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1134
Query: 952 -QAQSCRQQVAPTDD---------ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTN 1001
Q RQ++ D E + L+ + YQ+ R+ + LN+
Sbjct: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQ-FLRDTKQAE----AFLNNQE 1189
Query: 1002 KDWWKVEVNDRQGFVPAAYVKKLD--PAQSASRE--NLLEEQGSIALRQEQIDNQTRITK 1057
E+ AA K+ D A+ E N + E G + I N RI +
Sbjct: 1190 YVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNI-NSDRIQE 1248
Query: 1058 EAGSVSLRMKQVEELYHSLL-ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
+ S+ R ++ E LL L + R +KF+ ++ EL WINEK LT+
Sbjct: 1249 KVDSIDDRHRKNRETASELLMRLKDNR------DLQKFL--QDCQELSLWINEK--MLTA 1298
Query: 1117 EEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEV 1175
+++ D + K F +L +N+ L I K L SE E +AV ++++
Sbjct: 1299 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE---KPETEAVVKEKL 1355
Query: 1176 YGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEV 1235
G L++ W L+ + ++Q L A++
Sbjct: 1356 TG---------------------------------LHKMWEVLESTTQTKAQRLFDANKA 1382
Query: 1236 QRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGET 1295
+ F + + +W+ + +D+YG DL SV L +K + E + ++ L
Sbjct: 1383 ELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1442
Query: 1296 AERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWI 1355
A+ L Q +S +++ K + + L + ++RK L S ++ +F D D + W+
Sbjct: 1443 AQALSQ-EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501
Query: 1356 NGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE 1415
L +S + ++ + L++++Q + EI + Q ++ S E
Sbjct: 1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1561
Query: 1416 -IKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKG 1474
I+Q+L L Q L + +R L++ Q ++ D +AE WM+ +E ++ +E+K
Sbjct: 1562 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1621
Query: 1475 DSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWR 1534
S +++KKH+ ++A+ E + L + L+A H IS R+++V +
Sbjct: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1681
Query: 1535 RLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASD----ESYKDPTNIQLSKL 1590
LK E+R KL E L Q +R+VD++E WI+E+ A + Y+ T +Q
Sbjct: 1682 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ---- 1737
Query: 1591 LSKHQKHQAFEAEL-HANADRIRGVIDMGNSLIERGACAGSEDAVKARLA-ALADQWQFL 1648
++ + F + + +R+ V + + LI G S+ A A L + W L
Sbjct: 1738 ----ERFREFARDTGNIGQERVDTVNHLADELINSG---HSDAATIAEWKDGLNEAWADL 1790
Query: 1649 VQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLL 1708
++ ++Q L + + F K+ + + L E+ G+D +V L + H
Sbjct: 1791 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTF 1849
Query: 1709 EADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDT-INGRFQKIKSMAASRRAKLNE 1767
E DI A +++ L A L + A D + KR+ + ++ + SRR +L +
Sbjct: 1850 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1909
Query: 1768 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
+ +FF + D W+++ + +++ RD++ V+ L H+ ++AE+ A +
Sbjct: 1910 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1969
Query: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
++ GK L EEI+++L Q E KE+ R + L LE QF +
Sbjct: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
Query: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDR 1930
EAW+ + ++S + G ++ ++ L+K+HEAFE +R
Sbjct: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDER 2072
Score = 414 bits (1063), Expect = e-115
Identities = 355/1628 (21%), Positives = 714/1628 (43%), Gaps = 104/1628 (6%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIASDENYK 73
I R+ V+ + EL RRQ+LE + Q ++ + W+ E K+ + S + K
Sbjct: 499 ITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGK 558
Query: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS----ETIRTRLMELHR 129
++ LQKH EA++ + + ++ + ++G + IR R+ +
Sbjct: 559 HLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEF 618
Query: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
++ L + E+ +L ++++L ++ E + WI +KE I++S++ G+DL V L
Sbjct: 619 CYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLS 678
Query: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
K F+ +M+ + + +I E+H E I+ + + W L+ L+ R+
Sbjct: 679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
+L A+ + +F D D+ +W+ + ++++S D G D S Q+L++KH+ + ++A
Sbjct: 739 RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798
Query: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
+ L +A L Q H + ++ + + ++++ L R L D+ L + ++
Sbjct: 799 TLDTLHEQASALPQEH-AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
W+ E + +N ++ + E + R + + E++ ++ + L+
Sbjct: 858 ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 917
Query: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM-SKQEA 488
+GH + E++ + L+ + EL + ++ + +Q ++ + + +W+ K +
Sbjct: 918 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 977
Query: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
+DLG+ L V AL +K E+ L A E K++ L + A KL + + + +R
Sbjct: 978 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1037
Query: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
+ + R A L ++ LQQF RD D+ +SW++ +T T A +D N
Sbjct: 1038 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS---RTQTAIASEDMPNTL 1094
Query: 609 GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE--------VAARMNEVISLW 660
+ +K + ++ ID E+ QK+ D+ + R+ + + W
Sbjct: 1095 TEAEKLLTQHENI---KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW 1151
Query: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
+L + E + L +++ QQF R+ + E +L E LA + L + KK
Sbjct: 1152 NELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQ 1211
Query: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
+ A++++I+ + R+ G+ +++ I++K +++ R+ +E +L
Sbjct: 1212 EDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRL 1271
Query: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
D+ LQ+ +D ++ WI EK + A + + + KHQA AE+A ++ +
Sbjct: 1272 KDNRDLQKFLQDCQELSLWINEK-MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWL 1330
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
+ ++G ++ E VK KL L++ WE L++ + Q L D+ +A+ +
Sbjct: 1331 DKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1390
Query: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
+ + W+ E + S DYGKD S LLKK + L + + I+ L+ QAQ+ Q+
Sbjct: 1391 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG 1450
Query: 961 APTDDETGKELVLALYDYQEKSPREVTMKKGDILTL--LNSTNKD------WWKVEVNDR 1012
TD+ K L + + P + +K ++L ++ N+D W V +R
Sbjct: 1451 KSTDEVDSKRLTVQTKFMELLEP--LNERKHNLLASKEIHQFNRDVEDEILW----VGER 1504
Query: 1013 QGFVPAA-YVKKLDPAQSASRENLL---EEQGSIALRQEQIDNQTRITKEAGSVSL---- 1064
+ + L Q ++N E QG + + I ++ S+S
Sbjct: 1505 MPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR 1564
Query: 1065 -RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
R+ +++L+ L+E EKR LE++ + + +A E + W++E+E + SEE D
Sbjct: 1565 QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDE 1624
Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
+ + KK ++ ++ + ++K + L ++ E +++Q +V
Sbjct: 1625 QSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV-------- 1676
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
++ + L+ LAEER L H + + +R+ D
Sbjct: 1677 ----------------------------DKLYAGLKDLAEERRGKLDERHRLFQLNREVD 1708
Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALG-DKVNSLGETAERLIQS 1302
+ ++WI E+ + G D V LQ + F RD +G ++V+++ A+ LI S
Sbjct: 1709 DLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINS 1768
Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
A + E LN+AW+ L + D R L S++L +F D +++ I +
Sbjct: 1769 GHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQD-KHKK 1827
Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA--HGHYASPEIKQKL 1420
+EL +D E L H +I A + ++ +L A G A K++
Sbjct: 1828 LPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKREN 1887
Query: 1421 DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
++L+ ++ L+ +R ++D + + F WM + ++K + SV
Sbjct: 1888 EVLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VRDLMLWMEDVIRQIEAQEKPRDVSSV 1946
Query: 1481 EALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDI-------SSRRNEVLDRW 1533
E L+ H+ I+ + + L+A HYA +I + +R E++D+W
Sbjct: 1947 ELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKW 2006
Query: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
++ L + QFSRD EAW+ + S + ++ KL+
Sbjct: 2007 E-------DRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD-EVEKLI-- 2056
Query: 1594 HQKHQAFE 1601
++H+AFE
Sbjct: 2057 -KRHEAFE 2063
Score = 362 bits (930), Expect = 2e-99
Identities = 322/1435 (22%), Positives = 620/1435 (43%), Gaps = 129/1435 (8%)
Query: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI--ASDE 70
++I+ ++ ++ R+ +F+EL ++ L + Q + + E + WI+EK ++ ++ +
Sbjct: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983
Query: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
D + +K E ++ A + L + + SE ++ I +RL E+
Sbjct: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043
Query: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
WE + ++ + L +A KL Q+LR+ +D W++ + + SE++ L E L +
Sbjct: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQ 1103
Query: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAAWQRLKGLALQRQG 249
E + ++ +EE ++ + Q Q + + ++ + ++ W L + RQ
Sbjct: 1104 HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQN 1163
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
L + Q+F RD + +++ +E ++A + L +A ++K E + A E+
Sbjct: 1164 LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEE 1223
Query: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
K+ A+ RL +++ +IQ K + + + R A+E RL D+ LQ+FL D
Sbjct: 1224 KINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD 1283
Query: 370 FRDLTSWVTEMKALINADELASDVA-GAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
++L+ W+ E ++ A +++ D A + +HQ E+ ++++ ++ G L+
Sbjct: 1284 CQELSLWINEK--MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLI 1341
Query: 429 AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
+ V+EKLT L + L + + Q+ +LF + +D W+ E+
Sbjct: 1342 SEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLES 1401
Query: 489 FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
+ ++D G L SV LLKK + E + ++++I L A L Q + ++V ++R
Sbjct: 1402 QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKR 1460
Query: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNL 607
+ ++ L E R+ L S + QF RD ++ WV E+M AT + + +
Sbjct: 1461 LTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTV 1520
Query: 608 QGKVQKHQAFEAELSANQSRIDALEKAGQKLI-DVNHYAKDEVAARMNEVISLWKKLLEA 666
Q ++K+Q + E+ +Q RID + + Q ++ D + + + + R+ ++ LW L+E
Sbjct: 1521 QLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEE 1580
Query: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
TE + +L EA++ QQ+ + + E W+ E E ++ S++ KD + ++ KKH +LE
Sbjct: 1581 TEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQA 1640
Query: 727 VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
V + + + ++ +R H ++E I +Q + Y LK+ R+ KL + RL
Sbjct: 1641 VEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRL 1700
Query: 787 QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG-HEPRIKAVTQ 845
QL R+V+D E WI E+E +A S G+D V L ++ + + + R+ V
Sbjct: 1701 FQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNH 1760
Query: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905
+ ++ GH A + LN+ W L R Q L S + +++ DA E
Sbjct: 1761 LADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR 1820
Query: 906 MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965
+++K + + G+D+++ E L + H D+ A G+ ++ L+E A R Q A D
Sbjct: 1821 IQDKHKKLPE-ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA--ARLQAAYAGD 1877
Query: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA------ 1019
+ D +K EV +L S V+ D+ F
Sbjct: 1878 KA---------DDIQKRENEVLEAWKSLLDACESRRVRL--VDTGDKFRFFSMVRDLMLW 1926
Query: 1020 ---YVKKLD----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQV--E 1070
+++++ P +S E L+ I + ++ E G L K E
Sbjct: 1927 MEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE 1986
Query: 1071 ELYHSLLELGEKRKGMLEKSCKKF----------MLFREANELQQWINEKEAALTSEEVG 1120
E+ LL+L EKRK M++K ++ R+A+ + W+ +E L+S E+G
Sbjct: 1987 EIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIG 2046
Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDIN----------------------------- 1151
+++VE L K+ + F+K + R +
Sbjct: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPS 2106
Query: 1152 -KVAEDLESE--------------GLMAEE-----VQAVQQQEVYGMMPRDETDSKTASP 1191
KV+E+ ES+ GL AE+ + V E+ T SK +SP
Sbjct: 2107 TKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSP 2166
Query: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251
S + R+ + + + L HE + ++ A ++ W
Sbjct: 2167 IPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKAS-SRSW--- 2222
Query: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQ 1311
H++ V + + GF +D +TA I H E L+
Sbjct: 2223 -----------HNVYCV--INNQEMGFYKD-----------AKTAASGIPYHSEVPVSLK 2258
Query: 1312 EKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
E E+ + K+ K +L D ++ D ++ +WI I +SSD+
Sbjct: 2259 EAVCEVALDYK---KKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDK 2310
Score = 297 bits (760), Expect = 1e-79
Identities = 181/542 (33%), Positives = 293/542 (54%), Gaps = 5/542 (0%)
Query: 11 TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK-LQIASD 69
+AE I++R + + E + R ++LE+++R Q + DA E E W+ E+ L + S+
Sbjct: 1559 SAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE 1618
Query: 70 ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
E KD + L+KHQ E V+ + + +L +T ++++ H SE I R ++ +
Sbjct: 1619 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDK 1678
Query: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
+ L + E+ KL + +L Q RE +D+ WI ++E + S ELGQD EHV +LQ+
Sbjct: 1679 LYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE 1738
Query: 190 KFEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
+F EF D +ERV+ VN A +LI H + I +D +N AW L L R
Sbjct: 1739 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1798
Query: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
L + E+ +F D E I++K + + ++ GRD +V+ L R H E D+ AL
Sbjct: 1799 QILAASYELHKFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALG 1857
Query: 309 DKVKALCAEADRLQQSHPLS-ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFL 367
+V+ L +A RLQ ++ A IQ + E++ W+ + R RL D+ RF
Sbjct: 1858 TQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1917
Query: 368 ADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL 427
+ RDL W+ ++ I A E DV+ E L++ HQ K EIDA DSF + E G++L
Sbjct: 1918 SMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL 1977
Query: 428 LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487
LA HYAS+E++EKL L+E+R +++ WE R + +++ F RD + W+ QE
Sbjct: 1978 LARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQE 2037
Query: 488 AFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT-KLIQNNHYAMEDVAT 546
+L + ++G S+D VE L+K+HE FEKS + +E+ +AL+ T +L++ E+
Sbjct: 2038 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2097
Query: 547 RR 548
RR
Sbjct: 2098 RR 2099
Score = 251 bits (641), Expect = 6e-66
Identities = 212/911 (23%), Positives = 417/911 (45%), Gaps = 74/911 (8%)
Query: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIAS 68
ET ++E+ + + + + + Q+L D+ + + F + +L+KW+ + QI S
Sbjct: 1346 ETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQS 1405
Query: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE------TIRT 122
D+ KD T++ L+K Q E +++ I +L + EG E T++T
Sbjct: 1406 DDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT 1465
Query: 123 RLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLE 182
+ ME LLE + E+ LL ++++ Q+ R+ ED + W+ ++ + TS + G +L+
Sbjct: 1466 KFME-------LLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQ 1518
Query: 183 HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLK 241
V++L KK + Q ++ H+ R++++ + + ++ + E I+ + ++ W L
Sbjct: 1519 TVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLI 1578
Query: 242 GLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLE 301
+R +L A Q++ D E +W+ E+E M S++ +D S ++L+KH+ LE
Sbjct: 1579 EETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILE 1638
Query: 302 RDLAALEDKVKALCAEADRL-QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
+ + + V L + L SHP + +I +++ ++ + ++ LA ER +L++
Sbjct: 1639 QAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQSKVDKLYAGLKDLAEERRGKLDER 1697
Query: 361 YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEI-DAHEDSFKS 419
+RL + + DL W+ E + + + EL D L +R +E + + ++ +
Sbjct: 1698 HRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT 1757
Query: 420 ADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQV 479
+ L+ +GH + + E L+E A LLEL + R Q +L FY D +++
Sbjct: 1758 VNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1817
Query: 480 DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHY 539
+ + L E+LG ++VE L + H FE + A ++ L E A +L Y
Sbjct: 1818 FGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL--QAAY 1874
Query: 540 A---MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-T 595
A +D+ R + +L +L + RR +L D+ +FF +L W+ + ++
Sbjct: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI 1934
Query: 596 ATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNE 655
E +D S+++ + HQ +AE+ A + G+ L+ HYA +E+ ++ +
Sbjct: 1935 EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1994
Query: 656 VISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQN 715
+ K++++ E + LR + QF+R+ E WL E +L+S + G+ + V+
Sbjct: 1995 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEK 2054
Query: 716 LQKKHALLEADVAAHQDRIDGI-------TIQARQFQDAGHFD------------AENIK 756
L K+H E A +R + ++ R+ Q+ +E +
Sbjct: 2055 LIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAE 2114
Query: 757 KKQEALVARYEALKE---PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG 813
+Q+ ++ E + + P ++A+++ ++ ++ T +E PI + T+
Sbjct: 2115 SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSD- 2173
Query: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQK-- 871
K AL A+ A P A TQ+ + EG LN+K
Sbjct: 2174 ---------RKAKTALPAQSAATLP---ARTQETPSAQMEGF------------LNRKHE 2209
Query: 872 WEALKAKASQR 882
WEA KAS R
Sbjct: 2210 WEAHNKKASSR 2220
Score = 98.2 bits (243), Expect = 9e-20
Identities = 128/611 (20%), Positives = 244/611 (39%), Gaps = 86/611 (14%)
Query: 1751 FQKIKSMAASRRA------KLNESHRLHQFFRDM-DDEESWIKEKKLLVGSEDYGRDLTG 1803
F K+K++A + E+ ++ + + + D WI++ +++ + + L G
Sbjct: 277 FSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG 336
Query: 1804 VQ----------------------NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTI 1841
VQ NL +++++ A+ + + GK +SD N
Sbjct: 337 VQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE-GKLISDIN-- 393
Query: 1842 GKEEIQQRLAQFVEHWKELKQLAAARGQRL-EESLEY--QQFVANVEEEEAWINEKMTLV 1898
+ +RL + EH +EL A R + + +E LE ++F E W++E LV
Sbjct: 394 ---KAWERLEK-AEHEREL----ALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLV 445
Query: 1899 ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG 1958
+ +++G L A++ KKHEA ETD +++RV V ++L +N H + I+++
Sbjct: 446 SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 505
Query: 1959 LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQT 2018
+ L + R+ +L+ N + + + W+ E + + + DYG+ L V+
Sbjct: 506 VIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVED 565
Query: 2019 LLTKQETFDA--GLQAFQQEGI-ANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLA 2075
LL K +A G+QA + G+ A+ K + I R A + + +L
Sbjct: 566 LLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ 625
Query: 2076 NSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALR 2135
+A R+ +L E+ R++ F A++ W E+ L+ L + L
Sbjct: 626 LAAERRARLEES----RRLWKFFWEMAEE----EGWIREKEKILSSDDYGKDLTSVMRLL 677
Query: 2136 EAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERE 2195
H AF +S F Q + + + + + + E W NL+++ R+
Sbjct: 678 SKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRK 737
Query: 2196 LELQKEQRRQEENDKLRQEFAQHANAFHQWIQE----------------TRTYLLDGSCM 2239
L E L +F A+ W+ + T++ + +
Sbjct: 738 KRL--------EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDV 789
Query: 2240 VEESG-------TLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHST 2292
EE TL Q A ++H E +R +L IE+ + E L K T
Sbjct: 790 AEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL-RKQALQDT 848
Query: 2293 VGLAQQWDQLD 2303
+ L + + + D
Sbjct: 849 LALYKMFSEAD 859
Score = 47.8 bits (112), Expect = 1e-04
Identities = 61/296 (20%), Positives = 119/296 (40%), Gaps = 18/296 (6%)
Query: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
A Q G+ + +D ++ H K+I + +S++ A A K++ + +
Sbjct: 241 AEQHLGLTKLLDPED--ISVDHPDEKSIITYVVTYYHYFSKMKA-LAVEGKRIGKVLDNA 297
Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQ-A 2150
+ E + + AS W E L + NSL ++ +A + +R+ +
Sbjct: 298 IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 357
Query: 2151 DFNQLAELDRQIKSFRVASNPYTWFTMEA-----LEETWRNLQKIIKERELELQKEQRRQ 2205
+ L L I+S A+N + E + + W L+K EREL L+ E RQ
Sbjct: 358 EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 417
Query: 2206 EENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ----EIR 2261
E+ ++L + F + A W+ E + + + G +EA +KH+ +I
Sbjct: 418 EKLEQLARRFDRKAAMRETWLSENQRLVSQ-----DNFGFDLPAVEAATKKHEAIETDIA 472
Query: 2262 AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQI 2317
A +++ + + +E D K + + W+ L +L + LE +
Sbjct: 473 AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNL 528
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 568 bits (1463), Expect = e-161
Identities = 450/1737 (25%), Positives = 806/1737 (46%), Gaps = 151/1737 (8%)
Query: 610 KVQKHQAFEAELSANQSRIDALEKA------GQKLIDVNHYAKDEVAARMNEVISLWKKL 663
K Q+ E L QSR+ A + G+ + D+N + A ++L +L
Sbjct: 355 KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNEL 414
Query: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
+ +L+ + R F+R E WL E + +A D++G DL V+ +KKH +
Sbjct: 415 IRQEKLEQLARR-------FDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAI 467
Query: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
E D AA+++R+ + A++ + + D + I +++ ++ + L+E + +R+Q+L +
Sbjct: 468 ETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETT 527
Query: 784 LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
L LQ+LF+D+ W+ E + S GK L+ V++LL+KH+ ++A+IA ++KA+
Sbjct: 528 LALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAI 587
Query: 844 TQKGNAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
T E + D ++ ++ L Q +E L A+ R+ LE S + ++F + +
Sbjct: 588 TAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMD 647
Query: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQS--CRQ 958
EAESW++EKE I S DYGKD S L +KH+A +L + ++ + ++A R+
Sbjct: 648 EAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARK 707
Query: 959 QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA 1018
Q E + V A +D Q K K L ++ N ++ + +D + ++
Sbjct: 708 QFGHPQIEARIKEVSAQWD-QLKDLAAFCKKN-----LQDAENFFQFQGDADDLKAWLQD 761
Query: 1019 AY--------------VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL 1064
A+ + L E L E +G + ++Q +++ V+
Sbjct: 762 AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTH 821
Query: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
R++ + ELY ++ + R+ L+++ + +F E + + W+ EKE L E+ LE
Sbjct: 822 RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLE 881
Query: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDL-ESEGLMAEEVQAVQQQEVYGMMPRDE 1183
+EV+Q +FD +++K +++ +N A L ES + EV+ Q
Sbjct: 882 DLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDH---------- 931
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
LN RW++ Q L ER + + SA V + D +
Sbjct: 932 ---------------------------LNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
Query: 1244 ETKEWIEEKNQAL-NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
ET +WI +K + + +T + G DLA + A+QRK G ERD+AA+ +V++L +++L+ S
Sbjct: 965 ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDS 1024
Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
HPE ED+ ++ L + W L + ++ LG+ LQ FL D D +W++ + V
Sbjct: 1025 HPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAV 1084
Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQK 1419
+S+++ + + AE LL++H + EID ++Q ++ G++++ PE + Q+
Sbjct: 1085 ASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQR 1142
Query: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
L+ LD L + W R L QCL Q F +D +QAE ++ +E L + DSL++
Sbjct: 1143 LEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEA 1202
Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
EA I+K EDF ++ +K+ + ++L+A G+ I + + DR R+ +
Sbjct: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
Query: 1540 MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
E L ++ LQ F ++ E+ WI++KL T+ D SY + N+ +K KHQA
Sbjct: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLH-----NKWLKHQA 1317
Query: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
F AEL ++ + + G L++ + V +L AL W L + EK+Q L
Sbjct: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTA--LVSQKLEALHRLWDELQATTKEKTQHL 1375
Query: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719
A D + W+S +E L S+D GKDL SVN +L K + +E ++ ++ L
Sbjct: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEEL 1435
Query: 1720 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMD 1779
+L +Q S+ D +I RF + R+ +L S Q RD++
Sbjct: 1436 GELFAQVPSMGEEGG-------DADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLE 1488
Query: 1780 DEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN 1839
DE W++E+ L S DYG +L VQ KK++ L+ E+ H P ++ VL G++L +
Sbjct: 1489 DETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA 1548
Query: 1840 TIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVA 1899
I +++++RL W L++ AA R QRL ++ E QQ+ + +E EAWI E+ V
Sbjct: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI 1608
Query: 1900 SEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL 1959
S++ +LK+H + + + + + Q L+ + E I +
Sbjct: 1609 SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQV 1668
Query: 1960 NGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTL 2019
+ + L+ A +RK KL+ Q + D +E WI EKE + + G+D V L
Sbjct: 1669 DKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLL 1728
Query: 2020 LTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2079
K F A QE + N+ A ++L+ A H ++ I L + W+ LL
Sbjct: 1729 RDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDT 1788
Query: 2080 RKKKL------------------LEAQSHFRKVEDLFL------TFAKKASAFN------ 2109
R + L L + H ED+ L +F + +AF
Sbjct: 1789 RMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLL 1848
Query: 2110 ----SWFENAEEDLTDPVRCNSLEEIK-ALREAHDAFRSSLSSAQADFNQLAELDRQIKS 2164
F++ L E I+ +E A+++ L + QL + + +
Sbjct: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908
Query: 2165 FRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQ 2224
F +A + +W ++ II++ E + E+ R + +L ++ Q NA
Sbjct: 1909 FSMARDLLSW------------MESIIRQIETQ---ERPRDVSSVELLMKYHQGINA--- 1950
Query: 2225 WIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL 2281
ETR+ +C+ L+ Q +A++ ++++ + S+ K++ + A E L
Sbjct: 1951 -EIETRSKNF-SACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
Score = 519 bits (1337), Expect = e-146
Identities = 376/1418 (26%), Positives = 673/1418 (47%), Gaps = 93/1418 (6%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72
I+ R ++V ++ + K+L+ ++ L+D+ F FQ DA++L+ W+Q+ ++ S E+
Sbjct: 714 IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
Query: 73 -KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
+ T GK KH+ F E++ + G + L++ E S + RL L +
Sbjct: 774 DEGATRALGK--KHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELY 830
Query: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
+ ++ + + +L +A L E + W+ +KE + E+ LE +EV+Q +F
Sbjct: 831 QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
Query: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
+ +M +++ VN A L++ HP +K QD +N WQ + L +R+ +
Sbjct: 891 DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
Query: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQALLRKHEGLERDLAALEDK 310
A V + D +ET WI +K +++ S D GRDLA + A+ RK GLERD+AA++ +
Sbjct: 951 DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
Query: 311 VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370
V AL E+ +L SHP I +++ L W+ ++ + L + +LQ FL D
Sbjct: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
D +W++ + + ++++ + AE LL +H K EID H+DS++ ESG+ ++
Sbjct: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
Query: 431 GHYASDE----VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
+D + ++L L AL +WE R QC+ Q F +D +Q + +S Q
Sbjct: 1131 ---QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ 1187
Query: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
E L + + DSL++ EA ++K EDF S+ +K+ + + KL+ + + +
Sbjct: 1188 EYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKE 1247
Query: 547 RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606
+ + R +E+A L D+ LQ F ++ EL W+N+K+ T+ D +Y + N
Sbjct: 1248 KVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307
Query: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
L K KHQAF AEL++++ ++ ++ G++L+D V+ ++ + LW +L
Sbjct: 1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQAT 1367
Query: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
T+ K L A + D+ W+ +E L SDD GKDLT+V + K +E
Sbjct: 1368 TKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ 1427
Query: 727 VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
V ++ + + Q + G +I+K R+ L EP+ RK++L S
Sbjct: 1428 VNVRKEELGELFAQVPSMGEEGGDADLSIEK-------RFLDLLEPLGRRKKQLESSRAK 1480
Query: 787 QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK 846
Q+ RD+EDE W+ E+ P+A S + G +L VQ +KK+Q LQ EI GH PR++ V Q+
Sbjct: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
Query: 847 GNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
G +VE +D++ +L L W+ L+ A+ R Q L D+ +AQQY+ DA+EAE+W+
Sbjct: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
Query: 907 REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-------QQ 959
E+E V S + KDE+ A +LK+H + YG +I+ L +AQ +Q
Sbjct: 1601 GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQ 1660
Query: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
+ + K L D E+ R+ L N + K E +D + ++
Sbjct: 1661 IIRLQGQVDKHYA-GLKDVAEERKRK----------LENMYHLFQLKRETDDLEQWISEK 1709
Query: 1020 YVKKLDP--AQSASRENLLEEQ------GSIALRQEQIDNQTRITK--------EAGSVS 1063
+ P Q LL ++ + A+ QE++DN + EA +++
Sbjct: 1710 ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIA 1769
Query: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
+ E++ LLEL + R +L S F E+ I+EK L E+VG D
Sbjct: 1770 EWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELP-EDVGLDA 1828
Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
E + F+++L +++ VA L++ E+ +A+Q +E
Sbjct: 1829 STAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT-AYAGEKAEAIQNKE--------- 1878
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQRFHRDA 1242
+E++ W++L A R+QL+ +A + RF A
Sbjct: 1879 -------------------------QEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMA 1912
Query: 1243 DETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
+ W+E + + T D++SV+ L + H+G ++ ++ E E L+Q
Sbjct: 1913 RDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQR 1972
Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
+++E+++EK ++ + ++ + R +L ++ +F D +W+ +
Sbjct: 1973 QHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYL 2032
Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
+S + V E L++RH+ + A F A E+
Sbjct: 2033 ASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
Score = 474 bits (1220), Expect = e-133
Identities = 363/1523 (23%), Positives = 705/1523 (46%), Gaps = 93/1523 (6%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73
IQ+R + + ++ R+ +LE S R F + +E E WI+EK QI S +Y K
Sbjct: 608 IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGK 667
Query: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
D T++ +KH+AFE E++ + ++ + + M++ F I R+ E+ QW+
Sbjct: 668 DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQ 727
Query: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
L + L A+ Q+ + +D+ W+ D +++ E++GQD L KK ++
Sbjct: 728 LKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKD 787
Query: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
F ++ + + Q A +E ++ Q + +Q++ A RQ +L
Sbjct: 788 FLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ-ALRELYQQVVAQADLRQQRLQE 846
Query: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
A ++ + D W+ EKE+ +A + L ++ + + + L++++ L ++
Sbjct: 847 ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDG 906
Query: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
+ A+ L +S + +++ ++ L T W+ +TL +ER ++ + R+ + D +
Sbjct: 907 VNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966
Query: 374 TSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
+ W+T+ K + + +L D+AG A+ + + ++ A + + + Q L+ +
Sbjct: 967 SKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
Query: 433 YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492
+++ ++ L E L + + + + LQ F +D + W+S + + +
Sbjct: 1027 EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS 1086
Query: 493 EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN---HYAMEDVATRRD 549
ED+ +SL E LL++H + + ++ + E K+IQ Y + + R +
Sbjct: 1087 EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--LGQRLE 1144
Query: 550 ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQG 609
L + NAL R LA Q+F +D+ + ++ ++ + T + P +L+
Sbjct: 1145 GLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAH--LEPPDSLEA 1202
Query: 610 K---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
++K + F + N+ ++ + +G KL+ + D++ ++ + +K E
Sbjct: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
Query: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEA 725
+ + LR+ + Q F +N +++ LW+ + L S D D N+ N KH A
Sbjct: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVSYDEARNLHNKWLKHQAFVA 1320
Query: 726 DVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLR 785
++A+H+ ++ I + +Q D + +K EAL ++ L+ + Q L+ +
Sbjct: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
Query: 786 LQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
+ D WI E S + GKDL V +L K + ++ ++ + + +
Sbjct: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
Query: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905
+ +M EEG A ++ + +L + +R++ LE S Q D + W
Sbjct: 1441 QVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQLESSRAKLQISRDLEDETLW 1493
Query: 906 MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965
+ E+ P+ S DYG + + + +KK++ L +++ + ++ + ++ Q Q+ +
Sbjct: 1494 VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ----QLVEAAE 1549
Query: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025
++L L Q R G + L ++ + ++ ++ + ++ + +
Sbjct: 1550 IDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI- 1608
Query: 1026 PAQSASRENLLEEQGSIAL------RQEQIDNQTRITKEAGSVS--------------LR 1065
S E +E+G+I + +Q +++ R K+ S + +R
Sbjct: 1609 -----SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIR 1663
Query: 1066 MK-QVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
++ QV++ Y L ++ E+RK LE F L RE ++L+QWI+EKE +S E+G D +
Sbjct: 1664 LQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFD 1723
Query: 1125 QVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
V +L+ KF DF ++ A + R+ ++N E L G
Sbjct: 1724 HVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG---------------------H 1762
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
+++ T + WK LNE W L +L + R QLL +++++ R+
Sbjct: 1763 SEAATIAEWKDG---------------LNEMWADLLELIDTRMQLLAASYDLHRYFYTGA 1807
Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
E I+EK++ L D G D ++ ++ R H FER+L LG +V + A RL ++
Sbjct: 1808 EILGLIDEKHRELPED-VGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAY 1866
Query: 1304 P-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
E AE +Q K E++ AW +L R+ +L D+ D RF S RDL+SW+ I +
Sbjct: 1867 AGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI 1926
Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422
+ E +DV+ E L++ HQ EI+ R+ F A + G+ LL H AS EI++KL
Sbjct: 1927 ETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQ 1986
Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482
+ R ++ + W R L LE+ F RD AE W+ A+E +L + D G ++DSVE
Sbjct: 1987 VMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046
Query: 1483 LIKKHEDFDKAINVQEEKIAALQ 1505
LIK+HE F+K+ E+ AAL+
Sbjct: 2047 LIKRHEAFEKSTASWAERFAALE 2069
Score = 463 bits (1191), Expect = e-129
Identities = 383/1744 (21%), Positives = 783/1744 (44%), Gaps = 103/1744 (5%)
Query: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD 69
E+ E+ + RR+ L +R++KLE R F R A E W+ E ++ +
Sbjct: 397 ESLEEAEYRRELALRN-------ELIRQEKLEQLARR--FDRKAAMRETWLSENQRLVAQ 447
Query: 70 ENYK-DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
+N+ D ++ +KH+A E + A + L++ + E + + I R +
Sbjct: 448 DNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNIL 507
Query: 129 RQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQ 188
R W L E ++ + +L L + ++ +DW+++ +A + S E G+ L VE L
Sbjct: 508 RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLL 567
Query: 189 KKFEEFQTDMAAHEERVNEVNQFAAKLIQE---QHPEEELIKTKQDEVNAAWQRLKGLAL 245
+K + + D+A ++V + K + Q + ++I+ + + ++ L +A
Sbjct: 568 QKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAA 627
Query: 246 QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
R+ +L + + +F ++DE SWIKEKEQ+ +S D+G+DL SV L RKH+ E +L
Sbjct: 628 GRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELR 687
Query: 306 ALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQR 365
L+ ++ + EA + QI+ + +E+ W+Q++ LAA L D+ +
Sbjct: 688 GLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQ 747
Query: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
F D DL +W+ + L++ +++ D AL +H++ E++ + ++ Q
Sbjct: 748 FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807
Query: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
S +V +L L E ++ +LR+Q+ ++ +DL + +T+ + WM +
Sbjct: 808 G-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
Query: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVA 545
+E +L ++ D+L+ +E + + + ++ + +I ++ A L+++ H +V
Sbjct: 867 KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926
Query: 546 TRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKD 603
+D L +R A RR + + + + D +E W+ +K K +T + +D
Sbjct: 927 QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986
Query: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
+ + +K E +++A Q+R+DALE+ Q+L+D + K+++ R + LW+ L
Sbjct: 987 LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
Query: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
++ + + L E +Q Q F ++++D + WL + +AS+D + L + L ++HA +
Sbjct: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106
Query: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAEN--IKKKQEALVARYEALKEPMVARKQKLA 781
+ ++ HQD + ++ + G D E + ++ E L + AL +R LA
Sbjct: 1107 KDEIDGHQDSYQRVK-ESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
Query: 782 DSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841
L Q+ +D + E + +E A L + ++K + + + ++
Sbjct: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
Query: 842 AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901
+ GN +V EG+ ++ +K K+ + + KA + L D+L+ Q + + E
Sbjct: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285
Query: 902 AESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYG---SSIQALREQAQSCR 957
W+ +K ++ S D DE + KH+A +++L+++ +I A +Q +
Sbjct: 1286 LTLWINDK--LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEK 1343
Query: 958 QQVAPTDDETGKELVLALYDYQEKSPREVTM----KKGDILTLLNSTNKDWWKVEVNDRQ 1013
Q + E + L+D + + +E T + L L + + W + D+
Sbjct: 1344 PQFTALVSQK-LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ- 1401
Query: 1014 GFVPAAYVKKLDPAQSASREN-----LLEEQGSIALRQEQID----NQTRITKEAGSVSL 1064
++ DP + + N L + + +R+E++ + +E G L
Sbjct: 1402 -------LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
Query: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
+E+ + LLE +RK LE S K + R+ + W+ E+ S + G +L+
Sbjct: 1455 ---SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQ 1511
Query: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDET 1184
V++ KK Q ++ + R++D+ + + L + A E+ +E G
Sbjct: 1512 TVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQL----VEAAEIDCQDLEERLG------- 1560
Query: 1185 DSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADE 1244
L W L++ A R Q L A+E Q+++ DADE
Sbjct: 1561 -------------------------HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
Query: 1245 TKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS-H 1303
+ WI E+ + +D D + ++H +R + G + L A+ L+ + H
Sbjct: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGH 1655
Query: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
PE E + ++++ ++ L A++RK KL + + L + + DL WI+ + S
Sbjct: 1656 PE-GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVAS 1714
Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDA----RAGTFQAFEQFGQQLLAHGHYASPEIKQK 1419
S E+ +D L ++ ++ E A R AF ++L+ GH + I +
Sbjct: 1715 SPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI---ERLIDAGHSEAATIAEW 1771
Query: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
D L++ ADL + R +L +L + + + + L ED G +
Sbjct: 1772 KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL-PEDVGLDAST 1830
Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKA 1538
E+ + H F++ +++ ++ Q A +L A K + I ++ EV W+ L
Sbjct: 1831 AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLD 1890
Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
+R++L ++ +F ++ +W+ ++ E+ + P ++ +LL K+ HQ
Sbjct: 1891 ACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI--ETQERPRDVSSVELLMKY--HQ 1946
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
AE+ + +++G SL++R A E ++ +L + + + + +K + ++
Sbjct: 1947 GINAEIETRSKNFSACLELGESLLQRQHQASEE--IREKLQQVMSRRKEMNEKWEARWER 2004
Query: 1659 LKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1718
L+ + F+ + WL E LAS D+G + SV L+K+H+ E ++ +R
Sbjct: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064
Query: 1719 LKDL 1722
L
Sbjct: 2065 FAAL 2068
Score = 454 bits (1169), Expect = e-127
Identities = 388/1785 (21%), Positives = 792/1785 (44%), Gaps = 132/1785 (7%)
Query: 146 LQAQKLVQ-YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQT--DMAAHE 202
++ +K+++ Y D++ WI ++ S + L V+ + F ++T +
Sbjct: 298 IETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQ 357
Query: 203 ERVN-EVNQFAAKLIQEQHPEEELIKTKQD-----EVNAAWQRL------KGLALQ---- 246
E+ N EV F + + + T D ++N AW+ L + LAL+
Sbjct: 358 EKGNLEVLLFTIQ--SRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
Query: 247 RQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAA 306
RQ KL A +RF+R +W+ E ++L+A D+FG DLA+V+A +KHE +E D AA
Sbjct: 416 RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAA 473
Query: 307 LEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRF 366
E++V+AL A L++ + +I +++ ++ W ++ L R RL + LQ+
Sbjct: 474 YEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKL 533
Query: 367 LADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQA 426
D W+ E+KA + + E + E LL +H+ + +I D K+ +
Sbjct: 534 FQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLK 593
Query: 427 LLAAGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM 483
Y + ++++++ L + L + R+ Q EQ L F+ + ++ ++W+
Sbjct: 594 FTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWI 653
Query: 484 SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
++E + D G L SV L +KH+ FE L + + + + A ++ +
Sbjct: 654 KEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ 713
Query: 544 VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-K 602
+ R + ++ + L + A + L D+ + QF D+D+LK+W+ + + + E +
Sbjct: 714 IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
Query: 603 DPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKK 662
D + +KH+ F EL ++ ++ LE+ Q + + D V R+ + L+++
Sbjct: 774 DEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELYQQ 832
Query: 663 LLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHAL 722
++ +L+ +L+EA + ELW+ E E LA + L +++ +Q + +
Sbjct: 833 VVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDI 892
Query: 723 LEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
L+ ++ +IDG+ + A ++GH + +K+ Q+ L R++A + + R++ +
Sbjct: 893 LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
Query: 783 SLRLQQLFRDVEDEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841
+LR+ D E+ WI +K + ST + G+DL G+ + +K L+ ++A + R+
Sbjct: 953 ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVD 1012
Query: 842 AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901
A+ ++ +++ ED+ + L + W+ L+ + L + Q Q + D ++
Sbjct: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDD 1072
Query: 902 AESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVA 961
++W+ + V S D + AE LL++H + ++ + S Q ++E + Q
Sbjct: 1073 FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ--G 1130
Query: 962 PTDDE---TGKELV------LALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDR 1012
TD E G+ L AL E + G KD + E
Sbjct: 1131 QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG-----FQEFQKDAKQAEAILS 1185
Query: 1013 QGFVPAAYVKKLDPAQSASR--ENLLEEQGSIALRQEQI----DNQTRITKEAGSVSLRM 1066
A+++ D ++A + GS+ ++++ D+ ++ E S ++
Sbjct: 1186 NQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKI 1245
Query: 1067 KQ----VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGAD 1122
K+ +E+ + E ++ +L + + + EL WIN+K LTS++V D
Sbjct: 1246 KEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDVSYD 1303
Query: 1123 LEQVEVLQK--KFDDFQKDLKANESRLKDINK---------------VAEDLESEGLMAE 1165
E + K K F +L ++E L++I+ V++ LE+ + +
Sbjct: 1304 -EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWD 1362
Query: 1166 EVQAVQQQEVYGMMPRDETDSKTAS-------------------PWKSARLMVHTVATFN 1206
E+QA +++ + +D + + P K + +A
Sbjct: 1363 ELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLK 1422
Query: 1207 SIK--------ELNERWRSLQQLAEE---------------------RSQLLGSAHEVQR 1237
++ EL E + + + EE R + L S+ +
Sbjct: 1423 RVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQ 1482
Query: 1238 FHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297
RD ++ W+EE+ + +YG +L +VQ +K++ + ++ +V + + +
Sbjct: 1483 ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ 1542
Query: 1298 RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWING 1357
+L+++ +DL+E+ L +W L + A R +L D+++ Q++ D + +WI
Sbjct: 1543 QLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGE 1602
Query: 1358 IRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK 1417
V SDE+ KD GA +L+RH + ++ + Q LL+ GH +I
Sbjct: 1603 QELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQII 1662
Query: 1418 QKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477
+ +D+ A L+ +R+ L+ L R+ + E W++ +E ++ + G
Sbjct: 1663 RLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDF 1722
Query: 1478 DSVEALIKKHEDFDKAIN-VQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL 1536
D V L K DF + + +E++ + AF ++LI AGH I+ ++ + + W L
Sbjct: 1723 DHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADL 1782
Query: 1537 KAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQK 1596
+ + L S L ++ EI I EK + ++ D + + S H+
Sbjct: 1783 LELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAE-----SFHRV 1837
Query: 1597 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEK 1655
H AFE ELH +++ D+ L + A AG + +A++ + ++ WQ L+ A +
Sbjct: 1838 HTAFERELHLLGVQVQQFQDVATRL--QTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895
Query: 1656 SQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAH 1715
+L + + F + +D W+ + + +++ +D++SV L+K HQ + A+I
Sbjct: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955
Query: 1716 EDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFF 1775
+SL+ + ++++K + R +++ +R +L + QF
Sbjct: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015
Query: 1776 RDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
RD E+W+ ++ + S D+G + V+ L K+H+ E A+
Sbjct: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
Score = 420 bits (1080), Expect = e-117
Identities = 408/1856 (21%), Positives = 796/1856 (42%), Gaps = 139/1856 (7%)
Query: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEIDAHEDSFKSA 420
DL +W+ + ++N+ + A+ + G + L + KG ++ + +S
Sbjct: 313 DLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSR 372
Query: 421 DESGQALLAAGH---YASDEVR--EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
+ + H SD R E L R L +R+++ EQ + F R
Sbjct: 373 MRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLA--RRFDRK 430
Query: 476 TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
+ W+S+ + + ++ G L +VEA KKHE E +A EE++ AL++ A +L +
Sbjct: 431 AAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490
Query: 536 NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE-KMK 594
N++ + + R+D +L + L E RR +L + LQ+ F+D W++E K
Sbjct: 491 ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550
Query: 595 TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE---VAA 651
+ E K ++ +QKH+ EA+++ ++ A+ A K + Y + +
Sbjct: 551 LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
Query: 652 RMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLT 711
R++ + +++L + +L ++ + +F +++ E W+ E E +S DYGKDLT
Sbjct: 611 RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
Query: 712 NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771
+V LQ+KH E ++ ++ I +A F I+ + + + A+++ LK+
Sbjct: 671 SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730
Query: 772 PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831
K+ L D+ Q D +D + W+++ + + + G+D + L KKH+
Sbjct: 731 LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
Query: 832 EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891
E+ ++ + Q+ EE + DV +L L + ++ + A+A R+Q L+++L
Sbjct: 791 ELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849
Query: 892 AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
F + + E WM EKE + + + E + + + L ++ + I +
Sbjct: 850 LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909
Query: 952 QAQSCRQQVAPTDDETGK-----------------------ELVLALYDYQ---EKSPRE 985
A S + P E + + L +++Y E++ +
Sbjct: 910 AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969
Query: 986 VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKL-----DPAQSASRENLLEEQG 1040
+T K T + + KD + D G + A +KL D A +R + LE +
Sbjct: 970 ITDK-----TKVVESTKDLGR----DLAGII--AIQRKLSGLERDVAAIQARVDALERES 1018
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREA 1100
Q+ +D+ ++ G R K +EEL+ L + + ++ +L + + ++
Sbjct: 1019 -----QQLMDSHPEQKEDIGQ---RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
Query: 1101 NELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESE 1160
++ Q W++ + A+ SE++ L + E L ++ + ++ ++ + + + E +
Sbjct: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV--- 1127
Query: 1161 GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ 1220
+Q E + R ++ L+ W +L +
Sbjct: 1128 ------IQGQTDPEYLLLGQR--------------------------LEGLDTGWNALGR 1155
Query: 1221 LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFER 1280
+ E RS L Q F +DA + + + + L L + +A RK E F
Sbjct: 1156 MWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLG 1215
Query: 1281 DLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD 1340
+ DKV S ++ +L+ ++ ++EK + ++A + L D+ +
Sbjct: 1216 SMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE 1275
Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
LQ FL + ++L WIN + L S D + +HQ E+ + G + +
Sbjct: 1276 LQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334
Query: 1401 FGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENW 1460
G+QL+ + + QKL+ L + +L+ ++ L L + W
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394
Query: 1461 MAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG 1520
++A E L ++D G L SV ++ K + + +NV++E++ L A + G A
Sbjct: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
Query: 1521 DISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYK 1580
I R ++L+ R K Q+ R+KL Q SRD+++ W+ E+L A Y
Sbjct: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKL-------QISRDLEDETLWVEERLPLAQSADYG 1507
Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
TN+Q +L K K+Q + E+ + R+ V+ G L+E + ++ RL
Sbjct: 1508 --TNLQTVQLFMK--KNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD--LEERLGH 1561
Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNN 1700
L W L + +A + Q+L++AN+ Q + + + W+ E E + S++ KD
Sbjct: 1562 LQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIV 1621
Query: 1701 LLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAAS 1760
+LK+H + + + +K L S+A L+++ + Q+ + ++ + +K +A
Sbjct: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEE 1681
Query: 1761 RRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
R+ KL + L Q R+ DD E WI EK+L+ S + G+D V LR K + E A
Sbjct: 1682 RKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGA 1741
Query: 1821 -HEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQ 1879
+ + V ++L D I + E W +L +L R Q L S + +
Sbjct: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
Query: 1880 FVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT---VHKDRVNDVCT 1936
+ E I+EK + ED G + + + H AFE + V + DV T
Sbjct: 1802 YFYTGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
Query: 1937 NGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESW 1996
Q E I +K + ++ L A A R+ +L + + +F A + SW
Sbjct: 1861 RLQTAYA--GEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSW 1918
Query: 1997 IGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQS 2056
+ ++T + RD+SSV+ L+ + +A ++ + + + L + LL +H S
Sbjct: 1919 MESIIRQIETQERPRDVSSVELLMKYHQGINAEIET-RSKNFSACLELGESLLQRQHQAS 1977
Query: 2057 KAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAE 2116
+ I + +M R ++ AR ++L R + ++ F++ AS +W E
Sbjct: 1978 EEIREKLQQVMSRRKEMNEKWEARWERL-------RMLLEV-CQFSRDASVAEAWLIAQE 2029
Query: 2117 EDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE-LDRQIKSFRVASNP 2171
L ++++ ++ L + H+AF S +S F L + ++K ++A P
Sbjct: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085
Score = 280 bits (715), Expect = 2e-74
Identities = 224/998 (22%), Positives = 448/998 (44%), Gaps = 60/998 (6%)
Query: 4 SGVKVLETAED-----IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEK 58
SG KV++ D + +R + + ++ + R L FQ FQ+DA++ E
Sbjct: 1123 SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEA 1182
Query: 59 WIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS 117
+ ++ +A E + ++K + F ++ N ++ ++GN +++EG+ S
Sbjct: 1183 ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
Query: 118 ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEEL 177
+ I+ ++ + + EK +E + L +L +L+ C+++ WINDK ++TS+++
Sbjct: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDV 1300
Query: 178 GQD-LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236
D ++ K + F ++A+HE + ++ +L+ E+ L+ K + ++
Sbjct: 1301 SYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRL 1360
Query: 237 WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
W L+ ++ L A + + WI E + SDD G+DL SV +L K
Sbjct: 1361 WDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAK 1420
Query: 297 HEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHAR 356
+ +E + ++++ L A+ + + + I+ + +L+ R +
Sbjct: 1421 LKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQ 1473
Query: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416
L S + D D T WV E L + + +++ + + ++Q + EI H
Sbjct: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
Query: 417 FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476
+ + GQ L+ A ++ E+L L L E R Q+ + Q +Y D
Sbjct: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
Query: 477 EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN 536
++ + W+ +QE +++++++ + +LK+H ++++ I L A L+
Sbjct: 1594 DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA 1653
Query: 537 NHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA 596
H E + + + L + A R+ +L + +HL Q R++D+L+ W++EK A
Sbjct: 1654 GHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVA 1713
Query: 597 TD-EAYKDPSNLQGKVQKHQAFEAELSA-NQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
+ E +D ++ K + F E A Q R+D + ++LID H +A +
Sbjct: 1714 SSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKD 1773
Query: 655 EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714
+ +W LLE + + L + ++ +I L L + + +D G D + +
Sbjct: 1774 GLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI-LGLIDEKHRELPEDVGLDASTAE 1832
Query: 715 NLQKKHALLEADVAAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVAR 765
+ + H E ++ + +Q +QFQD AG AE I+ K++ + A
Sbjct: 1833 SFHRVHTAFERELHL-------LGVQVQQFQDVATRLQTAYAGE-KAEAIQNKEQEVSAA 1884
Query: 766 YEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKK 825
++AL + R+ +L D+ + F D +W+ + R +D+ V+ L+K
Sbjct: 1885 WQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKY 1944
Query: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH-------ELNQKWEALKAK 878
HQ + AEI A + G ++++ H A+E+++ KL E+N+KWEA
Sbjct: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA---- 2000
Query: 879 ASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD 938
R + L L+ Q+ DA+ AE+W+ +EP + S D+G DS E L+K+HEA
Sbjct: 2001 ---RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKS 2057
Query: 939 LSAYGSSIQAL----------REQAQSCRQQVAPTDDE 966
+++ AL R+ A+ ++ P ++E
Sbjct: 2058 TASWAERFAALEKPTTLELKERQIAERPAEETGPQEEE 2095
Score = 216 bits (551), Expect = 2e-55
Identities = 195/864 (22%), Positives = 366/864 (42%), Gaps = 71/864 (8%)
Query: 1544 RSKLGESQTLQQFSRDVDEI----EAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
R++L + L+Q +R D E W+SE + + +++ L+ + + +KH+A
Sbjct: 411 RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF----GYDLAAVEAAKKKHEA 466
Query: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
E + A +R+R + D+ L + + + AR + W +L + + Q+L
Sbjct: 467 IETDTAAYEERVRALEDLAQELEKENY--HDQKRITARKDNILRLWSYLQELLQSRRQRL 524
Query: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719
+ Q + W+ E++A L S ++GK L V +LL+KH+L+EADI+ D++
Sbjct: 525 ETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKV 584
Query: 1720 KDLNSQADSLMTSSAF---DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFR 1776
K + + + D ++D+ + F+++ +MAA R+A+L +S RL +FF
Sbjct: 585 KAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFW 644
Query: 1777 DMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLS 1836
+MD+ ESWIKEK+ + S DYG+DLT V L++KHK E EL + ++ + +
Sbjct: 645 EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704
Query: 1837 DDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT 1896
G +I+ R+ + W +LK LAA + L+++ + QF + ++ +AW+ +
Sbjct: 705 ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHR 764
Query: 1897 LVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKM 1956
L++ ED G A + L KKH+ F + + + + Q + +++ ++
Sbjct: 765 LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRL 823
Query: 1957 KGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSV 2016
+ L + A R+ +L E + D E W+GEKE L + L +
Sbjct: 824 QALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDL 883
Query: 2017 QTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLAN 2076
+ + + + D ++ + I + + L+ + H +S+ ++ L RW
Sbjct: 884 EVVQHRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTL 942
Query: 2077 SAARKKKL---LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2133
+ R++ + L ++ E+ K S +DL L I A
Sbjct: 943 VSERREAVDSALRVHNYCVDCEETSKWITDKTKVVES-----TKDLG-----RDLAGIIA 992
Query: 2134 LREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
++ +++ QA + L +Q+ + LEE W+ LQ+
Sbjct: 993 IQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ---- 1048
Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEAT 2253
LQ ++ E +L Q F Q + F W+ T+ + M E E L+
Sbjct: 1049 ---SLQGQEDLLGEVSQL-QAFLQDLDDFQAWLSITQKAVASED-MPESLPEAEQLLQQH 1103
Query: 2254 KRKHQEIRAMRSQLKKIEDLGAAM------EEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307
EI + +++++ G + E L+L + GL W+ L ++
Sbjct: 1104 AGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLE-----GLDTGWNALGRMWE 1158
Query: 2308 RMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKD---KSGRLNHQEFKSCLRSLGYDL 2364
H L Q + F+ F KD L++QE+ L
Sbjct: 1159 SRSHTLAQ------------------CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
Query: 2365 PMVEEGEPDPEFEAILDTVDPNRD 2388
E G +FE L +++ NRD
Sbjct: 1201 EAAEAG--IRKFEDFLGSMENNRD 1222
Score = 57.0 bits (136), Expect = 2e-07
Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 15/247 (6%)
Query: 2078 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2137
A K++ + H + E + ++ AS +W E L NSL ++ +A
Sbjct: 284 AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343
Query: 2138 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASN-----PYTWFTMEALEETWRNLQKII 2191
+R+ + + L L I+S A+N P+ + + W +L++
Sbjct: 344 FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403
Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2251
REL L+ E RQE+ ++L + F + A W+ E + + + G + +E
Sbjct: 404 YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQ-----DNFGYDLAAVE 458
Query: 2252 ATKRKHQEIR----AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307
A K+KH+ I A +++ +EDL +E+ D K + + W L +L
Sbjct: 459 AAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQ 518
Query: 2308 RMQHNLE 2314
+ LE
Sbjct: 519 SRRQRLE 525
Score = 45.1 bits (105), Expect = 9e-04
Identities = 75/396 (18%), Positives = 152/396 (38%), Gaps = 38/396 (9%)
Query: 1995 SWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA--FQQEGIANITALKDQLLAAK 2052
+WI + L + + L+ VQ L T+ + FQ++G N+ L + +
Sbjct: 316 TWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG--NLEVLLFTIQSRM 373
Query: 2053 HVQSKAIEARH-----ASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASA 2107
++ + H + + + W L R+ L K+E L F +KA+
Sbjct: 374 RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAM 433
Query: 2108 FNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRV 2167
+W + + L ++A ++ H+A + ++ + L +L ++++
Sbjct: 434 RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
Query: 2168 ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQ 2227
+ + W LQ++++ R L+ Q KL Q+ + W+
Sbjct: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQ----KLFQDMLHSID----WMD 545
Query: 2228 ETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA-MRSQLKKIEDLGAAM------EEA 2280
E + +LL E G ++E +KH+ + A + Q K++ + AA +
Sbjct: 546 EIKAHLLSA-----EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
Query: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA---LKEFSMMF 2337
D + + L Q +++L + + LEQ + +EA +KE ++
Sbjct: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
Query: 2338 KHFD--KDKSGRL----NHQEFKSCLRSLGYDLPMV 2367
D KD + L H+ F+ LR L L +
Sbjct: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQI 696
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 568 bits (1463), Expect = e-161
Identities = 450/1737 (25%), Positives = 806/1737 (46%), Gaps = 151/1737 (8%)
Query: 610 KVQKHQAFEAELSANQSRIDALEKA------GQKLIDVNHYAKDEVAARMNEVISLWKKL 663
K Q+ E L QSR+ A + G+ + D+N + A ++L +L
Sbjct: 355 KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNEL 414
Query: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
+ +L+ + R F+R E WL E + +A D++G DL V+ +KKH +
Sbjct: 415 IRQEKLEQLARR-------FDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAI 467
Query: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
E D AA+++R+ + A++ + + D + I +++ ++ + L+E + +R+Q+L +
Sbjct: 468 ETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETT 527
Query: 784 LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
L LQ+LF+D+ W+ E + S GK L+ V++LL+KH+ ++A+IA ++KA+
Sbjct: 528 LALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAI 587
Query: 844 TQKGNAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
T E + D ++ ++ L Q +E L A+ R+ LE S + ++F + +
Sbjct: 588 TAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMD 647
Query: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQS--CRQ 958
EAESW++EKE I S DYGKD S L +KH+A +L + ++ + ++A R+
Sbjct: 648 EAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARK 707
Query: 959 QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA 1018
Q E + V A +D Q K K L ++ N ++ + +D + ++
Sbjct: 708 QFGHPQIEARIKEVSAQWD-QLKDLAAFCKKN-----LQDAENFFQFQGDADDLKAWLQD 761
Query: 1019 AY--------------VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL 1064
A+ + L E L E +G + ++Q +++ V+
Sbjct: 762 AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTH 821
Query: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
R++ + ELY ++ + R+ L+++ + +F E + + W+ EKE L E+ LE
Sbjct: 822 RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLE 881
Query: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDL-ESEGLMAEEVQAVQQQEVYGMMPRDE 1183
+EV+Q +FD +++K +++ +N A L ES + EV+ Q
Sbjct: 882 DLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDH---------- 931
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
LN RW++ Q L ER + + SA V + D +
Sbjct: 932 ---------------------------LNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
Query: 1244 ETKEWIEEKNQAL-NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
ET +WI +K + + +T + G DLA + A+QRK G ERD+AA+ +V++L +++L+ S
Sbjct: 965 ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDS 1024
Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
HPE ED+ ++ L + W L + ++ LG+ LQ FL D D +W++ + V
Sbjct: 1025 HPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAV 1084
Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQK 1419
+S+++ + + AE LL++H + EID ++Q ++ G++++ PE + Q+
Sbjct: 1085 ASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQR 1142
Query: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
L+ LD L + W R L QCL Q F +D +QAE ++ +E L + DSL++
Sbjct: 1143 LEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEA 1202
Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
EA I+K EDF ++ +K+ + ++L+A G+ I + + DR R+ +
Sbjct: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
Query: 1540 MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
E L ++ LQ F ++ E+ WI++KL T+ D SY + N+ +K KHQA
Sbjct: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLH-----NKWLKHQA 1317
Query: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
F AEL ++ + + G L++ + V +L AL W L + EK+Q L
Sbjct: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTA--LVSQKLEALHRLWDELQATTKEKTQHL 1375
Query: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719
A D + W+S +E L S+D GKDL SVN +L K + +E ++ ++ L
Sbjct: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEEL 1435
Query: 1720 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMD 1779
+L +Q S+ D +I RF + R+ +L S Q RD++
Sbjct: 1436 GELFAQVPSMGEEGG-------DADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLE 1488
Query: 1780 DEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN 1839
DE W++E+ L S DYG +L VQ KK++ L+ E+ H P ++ VL G++L +
Sbjct: 1489 DETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA 1548
Query: 1840 TIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVA 1899
I +++++RL W L++ AA R QRL ++ E QQ+ + +E EAWI E+ V
Sbjct: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI 1608
Query: 1900 SEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL 1959
S++ +LK+H + + + + + Q L+ + E I +
Sbjct: 1609 SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQV 1668
Query: 1960 NGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTL 2019
+ + L+ A +RK KL+ Q + D +E WI EKE + + G+D V L
Sbjct: 1669 DKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLL 1728
Query: 2020 LTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2079
K F A QE + N+ A ++L+ A H ++ I L + W+ LL
Sbjct: 1729 RDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDT 1788
Query: 2080 RKKKL------------------LEAQSHFRKVEDLFL------TFAKKASAFN------ 2109
R + L L + H ED+ L +F + +AF
Sbjct: 1789 RMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLL 1848
Query: 2110 ----SWFENAEEDLTDPVRCNSLEEIK-ALREAHDAFRSSLSSAQADFNQLAELDRQIKS 2164
F++ L E I+ +E A+++ L + QL + + +
Sbjct: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908
Query: 2165 FRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQ 2224
F +A + +W ++ II++ E + E+ R + +L ++ Q NA
Sbjct: 1909 FSMARDLLSW------------MESIIRQIETQ---ERPRDVSSVELLMKYHQGINA--- 1950
Query: 2225 WIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL 2281
ETR+ +C+ L+ Q +A++ ++++ + S+ K++ + A E L
Sbjct: 1951 -EIETRSKNF-SACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
Score = 519 bits (1337), Expect = e-146
Identities = 376/1418 (26%), Positives = 673/1418 (47%), Gaps = 93/1418 (6%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72
I+ R ++V ++ + K+L+ ++ L+D+ F FQ DA++L+ W+Q+ ++ S E+
Sbjct: 714 IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
Query: 73 -KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
+ T GK KH+ F E++ + G + L++ E S + RL L +
Sbjct: 774 DEGATRALGK--KHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELY 830
Query: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
+ ++ + + +L +A L E + W+ +KE + E+ LE +EV+Q +F
Sbjct: 831 QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
Query: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
+ +M +++ VN A L++ HP +K QD +N WQ + L +R+ +
Sbjct: 891 DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
Query: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQALLRKHEGLERDLAALEDK 310
A V + D +ET WI +K +++ S D GRDLA + A+ RK GLERD+AA++ +
Sbjct: 951 DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
Query: 311 VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370
V AL E+ +L SHP I +++ L W+ ++ + L + +LQ FL D
Sbjct: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
D +W++ + + ++++ + AE LL +H K EID H+DS++ ESG+ ++
Sbjct: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
Query: 431 GHYASDE----VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
+D + ++L L AL +WE R QC+ Q F +D +Q + +S Q
Sbjct: 1131 ---QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ 1187
Query: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
E L + + DSL++ EA ++K EDF S+ +K+ + + KL+ + + +
Sbjct: 1188 EYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKE 1247
Query: 547 RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606
+ + R +E+A L D+ LQ F ++ EL W+N+K+ T+ D +Y + N
Sbjct: 1248 KVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307
Query: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
L K KHQAF AEL++++ ++ ++ G++L+D V+ ++ + LW +L
Sbjct: 1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQAT 1367
Query: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
T+ K L A + D+ W+ +E L SDD GKDLT+V + K +E
Sbjct: 1368 TKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ 1427
Query: 727 VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
V ++ + + Q + G +I+K R+ L EP+ RK++L S
Sbjct: 1428 VNVRKEELGELFAQVPSMGEEGGDADLSIEK-------RFLDLLEPLGRRKKQLESSRAK 1480
Query: 787 QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK 846
Q+ RD+EDE W+ E+ P+A S + G +L VQ +KK+Q LQ EI GH PR++ V Q+
Sbjct: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
Query: 847 GNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
G +VE +D++ +L L W+ L+ A+ R Q L D+ +AQQY+ DA+EAE+W+
Sbjct: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
Query: 907 REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-------QQ 959
E+E V S + KDE+ A +LK+H + YG +I+ L +AQ +Q
Sbjct: 1601 GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQ 1660
Query: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
+ + K L D E+ R+ L N + K E +D + ++
Sbjct: 1661 IIRLQGQVDKHYA-GLKDVAEERKRK----------LENMYHLFQLKRETDDLEQWISEK 1709
Query: 1020 YVKKLDP--AQSASRENLLEEQ------GSIALRQEQIDNQTRITK--------EAGSVS 1063
+ P Q LL ++ + A+ QE++DN + EA +++
Sbjct: 1710 ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIA 1769
Query: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
+ E++ LLEL + R +L S F E+ I+EK L E+VG D
Sbjct: 1770 EWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELP-EDVGLDA 1828
Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
E + F+++L +++ VA L++ E+ +A+Q +E
Sbjct: 1829 STAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT-AYAGEKAEAIQNKE--------- 1878
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQRFHRDA 1242
+E++ W++L A R+QL+ +A + RF A
Sbjct: 1879 -------------------------QEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMA 1912
Query: 1243 DETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
+ W+E + + T D++SV+ L + H+G ++ ++ E E L+Q
Sbjct: 1913 RDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQR 1972
Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
+++E+++EK ++ + ++ + R +L ++ +F D +W+ +
Sbjct: 1973 QHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYL 2032
Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
+S + V E L++RH+ + A F A E+
Sbjct: 2033 ASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
Score = 474 bits (1220), Expect = e-133
Identities = 363/1523 (23%), Positives = 705/1523 (46%), Gaps = 93/1523 (6%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73
IQ+R + + ++ R+ +LE S R F + +E E WI+EK QI S +Y K
Sbjct: 608 IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGK 667
Query: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
D T++ +KH+AFE E++ + ++ + + M++ F I R+ E+ QW+
Sbjct: 668 DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQ 727
Query: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
L + L A+ Q+ + +D+ W+ D +++ E++GQD L KK ++
Sbjct: 728 LKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKD 787
Query: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
F ++ + + Q A +E ++ Q + +Q++ A RQ +L
Sbjct: 788 FLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ-ALRELYQQVVAQADLRQQRLQE 846
Query: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
A ++ + D W+ EKE+ +A + L ++ + + + L++++ L ++
Sbjct: 847 ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDG 906
Query: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
+ A+ L +S + +++ ++ L T W+ +TL +ER ++ + R+ + D +
Sbjct: 907 VNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966
Query: 374 TSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
+ W+T+ K + + +L D+AG A+ + + ++ A + + + Q L+ +
Sbjct: 967 SKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
Query: 433 YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492
+++ ++ L E L + + + + LQ F +D + W+S + + +
Sbjct: 1027 EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS 1086
Query: 493 EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN---HYAMEDVATRRD 549
ED+ +SL E LL++H + + ++ + E K+IQ Y + + R +
Sbjct: 1087 EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--LGQRLE 1144
Query: 550 ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQG 609
L + NAL R LA Q+F +D+ + ++ ++ + T + P +L+
Sbjct: 1145 GLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAH--LEPPDSLEA 1202
Query: 610 K---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
++K + F + N+ ++ + +G KL+ + D++ ++ + +K E
Sbjct: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
Query: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEA 725
+ + LR+ + Q F +N +++ LW+ + L S D D N+ N KH A
Sbjct: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVSYDEARNLHNKWLKHQAFVA 1320
Query: 726 DVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLR 785
++A+H+ ++ I + +Q D + +K EAL ++ L+ + Q L+ +
Sbjct: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
Query: 786 LQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
+ D WI E S + GKDL V +L K + ++ ++ + + +
Sbjct: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
Query: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905
+ +M EEG A ++ + +L + +R++ LE S Q D + W
Sbjct: 1441 QVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQLESSRAKLQISRDLEDETLW 1493
Query: 906 MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965
+ E+ P+ S DYG + + + +KK++ L +++ + ++ + ++ Q Q+ +
Sbjct: 1494 VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ----QLVEAAE 1549
Query: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025
++L L Q R G + L ++ + ++ ++ + ++ + +
Sbjct: 1550 IDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI- 1608
Query: 1026 PAQSASRENLLEEQGSIAL------RQEQIDNQTRITKEAGSVS--------------LR 1065
S E +E+G+I + +Q +++ R K+ S + +R
Sbjct: 1609 -----SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIR 1663
Query: 1066 MK-QVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
++ QV++ Y L ++ E+RK LE F L RE ++L+QWI+EKE +S E+G D +
Sbjct: 1664 LQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFD 1723
Query: 1125 QVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
V +L+ KF DF ++ A + R+ ++N E L G
Sbjct: 1724 HVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG---------------------H 1762
Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
+++ T + WK LNE W L +L + R QLL +++++ R+
Sbjct: 1763 SEAATIAEWKDG---------------LNEMWADLLELIDTRMQLLAASYDLHRYFYTGA 1807
Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
E I+EK++ L D G D ++ ++ R H FER+L LG +V + A RL ++
Sbjct: 1808 EILGLIDEKHRELPED-VGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAY 1866
Query: 1304 P-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
E AE +Q K E++ AW +L R+ +L D+ D RF S RDL+SW+ I +
Sbjct: 1867 AGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI 1926
Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422
+ E +DV+ E L++ HQ EI+ R+ F A + G+ LL H AS EI++KL
Sbjct: 1927 ETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQ 1986
Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482
+ R ++ + W R L LE+ F RD AE W+ A+E +L + D G ++DSVE
Sbjct: 1987 VMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046
Query: 1483 LIKKHEDFDKAINVQEEKIAALQ 1505
LIK+HE F+K+ E+ AAL+
Sbjct: 2047 LIKRHEAFEKSTASWAERFAALE 2069
Score = 463 bits (1191), Expect = e-129
Identities = 383/1744 (21%), Positives = 783/1744 (44%), Gaps = 103/1744 (5%)
Query: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD 69
E+ E+ + RR+ L +R++KLE R F R A E W+ E ++ +
Sbjct: 397 ESLEEAEYRRELALRN-------ELIRQEKLEQLARR--FDRKAAMRETWLSENQRLVAQ 447
Query: 70 ENYK-DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
+N+ D ++ +KH+A E + A + L++ + E + + I R +
Sbjct: 448 DNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNIL 507
Query: 129 RQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQ 188
R W L E ++ + +L L + ++ +DW+++ +A + S E G+ L VE L
Sbjct: 508 RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLL 567
Query: 189 KKFEEFQTDMAAHEERVNEVNQFAAKLIQE---QHPEEELIKTKQDEVNAAWQRLKGLAL 245
+K + + D+A ++V + K + Q + ++I+ + + ++ L +A
Sbjct: 568 QKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAA 627
Query: 246 QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
R+ +L + + +F ++DE SWIKEKEQ+ +S D+G+DL SV L RKH+ E +L
Sbjct: 628 GRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELR 687
Query: 306 ALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQR 365
L+ ++ + EA + QI+ + +E+ W+Q++ LAA L D+ +
Sbjct: 688 GLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQ 747
Query: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
F D DL +W+ + L++ +++ D AL +H++ E++ + ++ Q
Sbjct: 748 FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807
Query: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
S +V +L L E ++ +LR+Q+ ++ +DL + +T+ + WM +
Sbjct: 808 G-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
Query: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVA 545
+E +L ++ D+L+ +E + + + ++ + +I ++ A L+++ H +V
Sbjct: 867 KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926
Query: 546 TRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKD 603
+D L +R A RR + + + + D +E W+ +K K +T + +D
Sbjct: 927 QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986
Query: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
+ + +K E +++A Q+R+DALE+ Q+L+D + K+++ R + LW+ L
Sbjct: 987 LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
Query: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
++ + + L E +Q Q F ++++D + WL + +AS+D + L + L ++HA +
Sbjct: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106
Query: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAEN--IKKKQEALVARYEALKEPMVARKQKLA 781
+ ++ HQD + ++ + G D E + ++ E L + AL +R LA
Sbjct: 1107 KDEIDGHQDSYQRVK-ESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
Query: 782 DSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841
L Q+ +D + E + +E A L + ++K + + + ++
Sbjct: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
Query: 842 AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901
+ GN +V EG+ ++ +K K+ + + KA + L D+L+ Q + + E
Sbjct: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285
Query: 902 AESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYG---SSIQALREQAQSCR 957
W+ +K ++ S D DE + KH+A +++L+++ +I A +Q +
Sbjct: 1286 LTLWINDK--LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEK 1343
Query: 958 QQVAPTDDETGKELVLALYDYQEKSPREVTM----KKGDILTLLNSTNKDWWKVEVNDRQ 1013
Q + E + L+D + + +E T + L L + + W + D+
Sbjct: 1344 PQFTALVSQK-LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ- 1401
Query: 1014 GFVPAAYVKKLDPAQSASREN-----LLEEQGSIALRQEQID----NQTRITKEAGSVSL 1064
++ DP + + N L + + +R+E++ + +E G L
Sbjct: 1402 -------LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
Query: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
+E+ + LLE +RK LE S K + R+ + W+ E+ S + G +L+
Sbjct: 1455 ---SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQ 1511
Query: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDET 1184
V++ KK Q ++ + R++D+ + + L + A E+ +E G
Sbjct: 1512 TVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQL----VEAAEIDCQDLEERLG------- 1560
Query: 1185 DSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADE 1244
L W L++ A R Q L A+E Q+++ DADE
Sbjct: 1561 -------------------------HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
Query: 1245 TKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS-H 1303
+ WI E+ + +D D + ++H +R + G + L A+ L+ + H
Sbjct: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGH 1655
Query: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
PE E + ++++ ++ L A++RK KL + + L + + DL WI+ + S
Sbjct: 1656 PE-GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVAS 1714
Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDA----RAGTFQAFEQFGQQLLAHGHYASPEIKQK 1419
S E+ +D L ++ ++ E A R AF ++L+ GH + I +
Sbjct: 1715 SPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI---ERLIDAGHSEAATIAEW 1771
Query: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
D L++ ADL + R +L +L + + + + L ED G +
Sbjct: 1772 KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL-PEDVGLDAST 1830
Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKA 1538
E+ + H F++ +++ ++ Q A +L A K + I ++ EV W+ L
Sbjct: 1831 AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLD 1890
Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
+R++L ++ +F ++ +W+ ++ E+ + P ++ +LL K+ HQ
Sbjct: 1891 ACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI--ETQERPRDVSSVELLMKY--HQ 1946
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
AE+ + +++G SL++R A E ++ +L + + + + +K + ++
Sbjct: 1947 GINAEIETRSKNFSACLELGESLLQRQHQASEE--IREKLQQVMSRRKEMNEKWEARWER 2004
Query: 1659 LKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1718
L+ + F+ + WL E LAS D+G + SV L+K+H+ E ++ +R
Sbjct: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064
Query: 1719 LKDL 1722
L
Sbjct: 2065 FAAL 2068
Score = 454 bits (1169), Expect = e-127
Identities = 388/1785 (21%), Positives = 792/1785 (44%), Gaps = 132/1785 (7%)
Query: 146 LQAQKLVQ-YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQT--DMAAHE 202
++ +K+++ Y D++ WI ++ S + L V+ + F ++T +
Sbjct: 298 IETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQ 357
Query: 203 ERVN-EVNQFAAKLIQEQHPEEELIKTKQD-----EVNAAWQRL------KGLALQ---- 246
E+ N EV F + + + T D ++N AW+ L + LAL+
Sbjct: 358 EKGNLEVLLFTIQ--SRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
Query: 247 RQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAA 306
RQ KL A +RF+R +W+ E ++L+A D+FG DLA+V+A +KHE +E D AA
Sbjct: 416 RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAA 473
Query: 307 LEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRF 366
E++V+AL A L++ + +I +++ ++ W ++ L R RL + LQ+
Sbjct: 474 YEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKL 533
Query: 367 LADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQA 426
D W+ E+KA + + E + E LL +H+ + +I D K+ +
Sbjct: 534 FQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLK 593
Query: 427 LLAAGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM 483
Y + ++++++ L + L + R+ Q EQ L F+ + ++ ++W+
Sbjct: 594 FTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWI 653
Query: 484 SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
++E + D G L SV L +KH+ FE L + + + + A ++ +
Sbjct: 654 KEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ 713
Query: 544 VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-K 602
+ R + ++ + L + A + L D+ + QF D+D+LK+W+ + + + E +
Sbjct: 714 IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
Query: 603 DPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKK 662
D + +KH+ F EL ++ ++ LE+ Q + + D V R+ + L+++
Sbjct: 774 DEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELYQQ 832
Query: 663 LLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHAL 722
++ +L+ +L+EA + ELW+ E E LA + L +++ +Q + +
Sbjct: 833 VVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDI 892
Query: 723 LEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
L+ ++ +IDG+ + A ++GH + +K+ Q+ L R++A + + R++ +
Sbjct: 893 LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
Query: 783 SLRLQQLFRDVEDEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841
+LR+ D E+ WI +K + ST + G+DL G+ + +K L+ ++A + R+
Sbjct: 953 ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVD 1012
Query: 842 AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901
A+ ++ +++ ED+ + L + W+ L+ + L + Q Q + D ++
Sbjct: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDD 1072
Query: 902 AESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVA 961
++W+ + V S D + AE LL++H + ++ + S Q ++E + Q
Sbjct: 1073 FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ--G 1130
Query: 962 PTDDE---TGKELV------LALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDR 1012
TD E G+ L AL E + G KD + E
Sbjct: 1131 QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG-----FQEFQKDAKQAEAILS 1185
Query: 1013 QGFVPAAYVKKLDPAQSASR--ENLLEEQGSIALRQEQI----DNQTRITKEAGSVSLRM 1066
A+++ D ++A + GS+ ++++ D+ ++ E S ++
Sbjct: 1186 NQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKI 1245
Query: 1067 KQ----VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGAD 1122
K+ +E+ + E ++ +L + + + EL WIN+K LTS++V D
Sbjct: 1246 KEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDVSYD 1303
Query: 1123 LEQVEVLQK--KFDDFQKDLKANESRLKDINK---------------VAEDLESEGLMAE 1165
E + K K F +L ++E L++I+ V++ LE+ + +
Sbjct: 1304 -EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWD 1362
Query: 1166 EVQAVQQQEVYGMMPRDETDSKTAS-------------------PWKSARLMVHTVATFN 1206
E+QA +++ + +D + + P K + +A
Sbjct: 1363 ELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLK 1422
Query: 1207 SIK--------ELNERWRSLQQLAEE---------------------RSQLLGSAHEVQR 1237
++ EL E + + + EE R + L S+ +
Sbjct: 1423 RVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQ 1482
Query: 1238 FHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297
RD ++ W+EE+ + +YG +L +VQ +K++ + ++ +V + + +
Sbjct: 1483 ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ 1542
Query: 1298 RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWING 1357
+L+++ +DL+E+ L +W L + A R +L D+++ Q++ D + +WI
Sbjct: 1543 QLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGE 1602
Query: 1358 IRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK 1417
V SDE+ KD GA +L+RH + ++ + Q LL+ GH +I
Sbjct: 1603 QELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQII 1662
Query: 1418 QKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477
+ +D+ A L+ +R+ L+ L R+ + E W++ +E ++ + G
Sbjct: 1663 RLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDF 1722
Query: 1478 DSVEALIKKHEDFDKAIN-VQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL 1536
D V L K DF + + +E++ + AF ++LI AGH I+ ++ + + W L
Sbjct: 1723 DHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADL 1782
Query: 1537 KAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQK 1596
+ + L S L ++ EI I EK + ++ D + + S H+
Sbjct: 1783 LELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAE-----SFHRV 1837
Query: 1597 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEK 1655
H AFE ELH +++ D+ L + A AG + +A++ + ++ WQ L+ A +
Sbjct: 1838 HTAFERELHLLGVQVQQFQDVATRL--QTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895
Query: 1656 SQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAH 1715
+L + + F + +D W+ + + +++ +D++SV L+K HQ + A+I
Sbjct: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955
Query: 1716 EDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFF 1775
+SL+ + ++++K + R +++ +R +L + QF
Sbjct: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015
Query: 1776 RDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
RD E+W+ ++ + S D+G + V+ L K+H+ E A+
Sbjct: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
Score = 420 bits (1080), Expect = e-117
Identities = 408/1856 (21%), Positives = 796/1856 (42%), Gaps = 139/1856 (7%)
Query: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEIDAHEDSFKSA 420
DL +W+ + ++N+ + A+ + G + L + KG ++ + +S
Sbjct: 313 DLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSR 372
Query: 421 DESGQALLAAGH---YASDEVR--EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
+ + H SD R E L R L +R+++ EQ + F R
Sbjct: 373 MRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLA--RRFDRK 430
Query: 476 TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
+ W+S+ + + ++ G L +VEA KKHE E +A EE++ AL++ A +L +
Sbjct: 431 AAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490
Query: 536 NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE-KMK 594
N++ + + R+D +L + L E RR +L + LQ+ F+D W++E K
Sbjct: 491 ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550
Query: 595 TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE---VAA 651
+ E K ++ +QKH+ EA+++ ++ A+ A K + Y + +
Sbjct: 551 LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
Query: 652 RMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLT 711
R++ + +++L + +L ++ + +F +++ E W+ E E +S DYGKDLT
Sbjct: 611 RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
Query: 712 NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771
+V LQ+KH E ++ ++ I +A F I+ + + + A+++ LK+
Sbjct: 671 SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730
Query: 772 PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831
K+ L D+ Q D +D + W+++ + + + G+D + L KKH+
Sbjct: 731 LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
Query: 832 EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891
E+ ++ + Q+ EE + DV +L L + ++ + A+A R+Q L+++L
Sbjct: 791 ELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849
Query: 892 AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
F + + E WM EKE + + + E + + + L ++ + I +
Sbjct: 850 LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909
Query: 952 QAQSCRQQVAPTDDETGK-----------------------ELVLALYDYQ---EKSPRE 985
A S + P E + + L +++Y E++ +
Sbjct: 910 AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969
Query: 986 VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKL-----DPAQSASRENLLEEQG 1040
+T K T + + KD + D G + A +KL D A +R + LE +
Sbjct: 970 ITDK-----TKVVESTKDLGR----DLAGII--AIQRKLSGLERDVAAIQARVDALERES 1018
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREA 1100
Q+ +D+ ++ G R K +EEL+ L + + ++ +L + + ++
Sbjct: 1019 -----QQLMDSHPEQKEDIGQ---RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
Query: 1101 NELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESE 1160
++ Q W++ + A+ SE++ L + E L ++ + ++ ++ + + + E +
Sbjct: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV--- 1127
Query: 1161 GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ 1220
+Q E + R ++ L+ W +L +
Sbjct: 1128 ------IQGQTDPEYLLLGQR--------------------------LEGLDTGWNALGR 1155
Query: 1221 LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFER 1280
+ E RS L Q F +DA + + + + L L + +A RK E F
Sbjct: 1156 MWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLG 1215
Query: 1281 DLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD 1340
+ DKV S ++ +L+ ++ ++EK + ++A + L D+ +
Sbjct: 1216 SMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE 1275
Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
LQ FL + ++L WIN + L S D + +HQ E+ + G + +
Sbjct: 1276 LQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334
Query: 1401 FGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENW 1460
G+QL+ + + QKL+ L + +L+ ++ L L + W
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394
Query: 1461 MAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG 1520
++A E L ++D G L SV ++ K + + +NV++E++ L A + G A
Sbjct: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
Query: 1521 DISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYK 1580
I R ++L+ R K Q+ R+KL Q SRD+++ W+ E+L A Y
Sbjct: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKL-------QISRDLEDETLWVEERLPLAQSADYG 1507
Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
TN+Q +L K K+Q + E+ + R+ V+ G L+E + ++ RL
Sbjct: 1508 --TNLQTVQLFMK--KNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD--LEERLGH 1561
Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNN 1700
L W L + +A + Q+L++AN+ Q + + + W+ E E + S++ KD
Sbjct: 1562 LQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIV 1621
Query: 1701 LLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAAS 1760
+LK+H + + + +K L S+A L+++ + Q+ + ++ + +K +A
Sbjct: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEE 1681
Query: 1761 RRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
R+ KL + L Q R+ DD E WI EK+L+ S + G+D V LR K + E A
Sbjct: 1682 RKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGA 1741
Query: 1821 -HEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQ 1879
+ + V ++L D I + E W +L +L R Q L S + +
Sbjct: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
Query: 1880 FVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT---VHKDRVNDVCT 1936
+ E I+EK + ED G + + + H AFE + V + DV T
Sbjct: 1802 YFYTGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
Query: 1937 NGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESW 1996
Q E I +K + ++ L A A R+ +L + + +F A + SW
Sbjct: 1861 RLQTAYA--GEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSW 1918
Query: 1997 IGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQS 2056
+ ++T + RD+SSV+ L+ + +A ++ + + + L + LL +H S
Sbjct: 1919 MESIIRQIETQERPRDVSSVELLMKYHQGINAEIET-RSKNFSACLELGESLLQRQHQAS 1977
Query: 2057 KAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAE 2116
+ I + +M R ++ AR ++L R + ++ F++ AS +W E
Sbjct: 1978 EEIREKLQQVMSRRKEMNEKWEARWERL-------RMLLEV-CQFSRDASVAEAWLIAQE 2029
Query: 2117 EDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE-LDRQIKSFRVASNP 2171
L ++++ ++ L + H+AF S +S F L + ++K ++A P
Sbjct: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085
Score = 280 bits (715), Expect = 2e-74
Identities = 224/998 (22%), Positives = 448/998 (44%), Gaps = 60/998 (6%)
Query: 4 SGVKVLETAED-----IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEK 58
SG KV++ D + +R + + ++ + R L FQ FQ+DA++ E
Sbjct: 1123 SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEA 1182
Query: 59 WIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS 117
+ ++ +A E + ++K + F ++ N ++ ++GN +++EG+ S
Sbjct: 1183 ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
Query: 118 ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEEL 177
+ I+ ++ + + EK +E + L +L +L+ C+++ WINDK ++TS+++
Sbjct: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDV 1300
Query: 178 GQD-LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236
D ++ K + F ++A+HE + ++ +L+ E+ L+ K + ++
Sbjct: 1301 SYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRL 1360
Query: 237 WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
W L+ ++ L A + + WI E + SDD G+DL SV +L K
Sbjct: 1361 WDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAK 1420
Query: 297 HEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHAR 356
+ +E + ++++ L A+ + + + I+ + +L+ R +
Sbjct: 1421 LKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQ 1473
Query: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416
L S + D D T WV E L + + +++ + + ++Q + EI H
Sbjct: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
Query: 417 FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476
+ + GQ L+ A ++ E+L L L E R Q+ + Q +Y D
Sbjct: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
Query: 477 EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN 536
++ + W+ +QE +++++++ + +LK+H ++++ I L A L+
Sbjct: 1594 DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA 1653
Query: 537 NHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA 596
H E + + + L + A R+ +L + +HL Q R++D+L+ W++EK A
Sbjct: 1654 GHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVA 1713
Query: 597 TD-EAYKDPSNLQGKVQKHQAFEAELSA-NQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
+ E +D ++ K + F E A Q R+D + ++LID H +A +
Sbjct: 1714 SSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKD 1773
Query: 655 EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714
+ +W LLE + + L + ++ +I L L + + +D G D + +
Sbjct: 1774 GLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI-LGLIDEKHRELPEDVGLDASTAE 1832
Query: 715 NLQKKHALLEADVAAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVAR 765
+ + H E ++ + +Q +QFQD AG AE I+ K++ + A
Sbjct: 1833 SFHRVHTAFERELHL-------LGVQVQQFQDVATRLQTAYAGE-KAEAIQNKEQEVSAA 1884
Query: 766 YEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKK 825
++AL + R+ +L D+ + F D +W+ + R +D+ V+ L+K
Sbjct: 1885 WQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKY 1944
Query: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH-------ELNQKWEALKAK 878
HQ + AEI A + G ++++ H A+E+++ KL E+N+KWEA
Sbjct: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA---- 2000
Query: 879 ASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD 938
R + L L+ Q+ DA+ AE+W+ +EP + S D+G DS E L+K+HEA
Sbjct: 2001 ---RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKS 2057
Query: 939 LSAYGSSIQAL----------REQAQSCRQQVAPTDDE 966
+++ AL R+ A+ ++ P ++E
Sbjct: 2058 TASWAERFAALEKPTTLELKERQIAERPAEETGPQEEE 2095
Score = 216 bits (551), Expect = 2e-55
Identities = 195/864 (22%), Positives = 366/864 (42%), Gaps = 71/864 (8%)
Query: 1544 RSKLGESQTLQQFSRDVDEI----EAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
R++L + L+Q +R D E W+SE + + +++ L+ + + +KH+A
Sbjct: 411 RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF----GYDLAAVEAAKKKHEA 466
Query: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
E + A +R+R + D+ L + + + AR + W +L + + Q+L
Sbjct: 467 IETDTAAYEERVRALEDLAQELEKENY--HDQKRITARKDNILRLWSYLQELLQSRRQRL 524
Query: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719
+ Q + W+ E++A L S ++GK L V +LL+KH+L+EADI+ D++
Sbjct: 525 ETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKV 584
Query: 1720 KDLNSQADSLMTSSAF---DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFR 1776
K + + + D ++D+ + F+++ +MAA R+A+L +S RL +FF
Sbjct: 585 KAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFW 644
Query: 1777 DMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLS 1836
+MD+ ESWIKEK+ + S DYG+DLT V L++KHK E EL + ++ + +
Sbjct: 645 EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704
Query: 1837 DDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT 1896
G +I+ R+ + W +LK LAA + L+++ + QF + ++ +AW+ +
Sbjct: 705 ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHR 764
Query: 1897 LVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKM 1956
L++ ED G A + L KKH+ F + + + + Q + +++ ++
Sbjct: 765 LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRL 823
Query: 1957 KGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSV 2016
+ L + A R+ +L E + D E W+GEKE L + L +
Sbjct: 824 QALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDL 883
Query: 2017 QTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLAN 2076
+ + + + D ++ + I + + L+ + H +S+ ++ L RW
Sbjct: 884 EVVQHRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTL 942
Query: 2077 SAARKKKL---LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2133
+ R++ + L ++ E+ K S +DL L I A
Sbjct: 943 VSERREAVDSALRVHNYCVDCEETSKWITDKTKVVES-----TKDLG-----RDLAGIIA 992
Query: 2134 LREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
++ +++ QA + L +Q+ + LEE W+ LQ+
Sbjct: 993 IQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ---- 1048
Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEAT 2253
LQ ++ E +L Q F Q + F W+ T+ + M E E L+
Sbjct: 1049 ---SLQGQEDLLGEVSQL-QAFLQDLDDFQAWLSITQKAVASED-MPESLPEAEQLLQQH 1103
Query: 2254 KRKHQEIRAMRSQLKKIEDLGAAM------EEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307
EI + +++++ G + E L+L + GL W+ L ++
Sbjct: 1104 AGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLE-----GLDTGWNALGRMWE 1158
Query: 2308 RMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKD---KSGRLNHQEFKSCLRSLGYDL 2364
H L Q + F+ F KD L++QE+ L
Sbjct: 1159 SRSHTLAQ------------------CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
Query: 2365 PMVEEGEPDPEFEAILDTVDPNRD 2388
E G +FE L +++ NRD
Sbjct: 1201 EAAEAG--IRKFEDFLGSMENNRD 1222
Score = 57.0 bits (136), Expect = 2e-07
Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 15/247 (6%)
Query: 2078 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2137
A K++ + H + E + ++ AS +W E L NSL ++ +A
Sbjct: 284 AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343
Query: 2138 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASN-----PYTWFTMEALEETWRNLQKII 2191
+R+ + + L L I+S A+N P+ + + W +L++
Sbjct: 344 FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403
Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2251
REL L+ E RQE+ ++L + F + A W+ E + + + G + +E
Sbjct: 404 YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQ-----DNFGYDLAAVE 458
Query: 2252 ATKRKHQEIR----AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307
A K+KH+ I A +++ +EDL +E+ D K + + W L +L
Sbjct: 459 AAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQ 518
Query: 2308 RMQHNLE 2314
+ LE
Sbjct: 519 SRRQRLE 525
Score = 45.1 bits (105), Expect = 9e-04
Identities = 75/396 (18%), Positives = 152/396 (38%), Gaps = 38/396 (9%)
Query: 1995 SWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA--FQQEGIANITALKDQLLAAK 2052
+WI + L + + L+ VQ L T+ + FQ++G N+ L + +
Sbjct: 316 TWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG--NLEVLLFTIQSRM 373
Query: 2053 HVQSKAIEARH-----ASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASA 2107
++ + H + + + W L R+ L K+E L F +KA+
Sbjct: 374 RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAM 433
Query: 2108 FNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRV 2167
+W + + L ++A ++ H+A + ++ + L +L ++++
Sbjct: 434 RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
Query: 2168 ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQ 2227
+ + W LQ++++ R L+ Q KL Q+ + W+
Sbjct: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQ----KLFQDMLHSID----WMD 545
Query: 2228 ETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA-MRSQLKKIEDLGAAM------EEA 2280
E + +LL E G ++E +KH+ + A + Q K++ + AA +
Sbjct: 546 EIKAHLLSA-----EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
Query: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA---LKEFSMMF 2337
D + + L Q +++L + + LEQ + +EA +KE ++
Sbjct: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
Query: 2338 KHFD--KDKSGRL----NHQEFKSCLRSLGYDLPMV 2367
D KD + L H+ F+ LR L L +
Sbjct: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQI 696
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 558 bits (1439), Expect = e-158
Identities = 447/1782 (25%), Positives = 793/1782 (44%), Gaps = 142/1782 (7%)
Query: 582 SDELKSWVNEKMKTATDEAYKDP-SNLQGKVQKHQAF----------------------E 618
+ EL W+ + + T D + S +Q ++Q ++ +
Sbjct: 314 ASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQ 373
Query: 619 AELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN 678
++L AN ++ + G+ + D+N + A ++L +L+ +L+ + R
Sbjct: 374 SKLRANNQKVYT-PREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAAR--- 429
Query: 679 QQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGIT 738
F+R E WL E + ++ D++G +L V+ +KH +E D+ A+ R+ +
Sbjct: 430 ----FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVD 485
Query: 739 IQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEET 798
A + + D + I +Q + ++ L++ + AR+++L +L LQ++F+D+
Sbjct: 486 AVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMD 545
Query: 799 WIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGH--- 855
W+ E + S + G+ L GV++LL+ H+ ++A+IA R++AV+ G
Sbjct: 546 WMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR 605
Query: 856 -FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVG 914
+ V ++ +L Q +EAL A+ RR LE+S + ++ + EAE+W+RE++ ++
Sbjct: 606 PCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLA 665
Query: 915 STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLA 974
S D G+D A LL KH AL ++S ++ EQ Q + P +
Sbjct: 666 SADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAA-- 723
Query: 975 LYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY-------------- 1020
+ Q + R + + L + + ++ + ND + ++ A
Sbjct: 724 --ELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFS 781
Query: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
+ L A E + + ++ +EQ V R+ +E Y L
Sbjct: 782 TQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARA 841
Query: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140
+R LE + + + EA W+ EKE L + LE +EV+Q++F+ + ++
Sbjct: 842 GERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEM 901
Query: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200
+++ +N +AE L A+P R++
Sbjct: 902 NTLAAQITAVNDIAEQLLK-----------------------------ANPPGKDRIV-- 930
Query: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL-NTD 1259
N+ ++LN RW+ ++LA+ + L SA +Q +H + ET+ W+ EK + + +T
Sbjct: 931 -----NTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQ 985
Query: 1260 NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQ 1319
G+DLA V ALQRK G ERDL A+ +V L A L HP A + + E+
Sbjct: 986 GLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQT 1045
Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLE 1379
W L +R+ LG++ LQ FL D +W+ + V+S+E + AEALL
Sbjct: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105
Query: 1380 RHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQKLDILDQERADLEKAWVQ 1436
+H R E++ + G+++ A P+ ++Q+L+ L +L + W
Sbjct: 1106 QHAALRGEVERAQSEYSRLRALGEEVTRD--QADPQCLFLRQRLEALGTGWEELGRMWES 1163
Query: 1437 RRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINV 1496
R+ L Q Q F RD QAE ++++E L+ + +L + +A IKK EDF ++
Sbjct: 1164 RQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDA 1223
Query: 1497 QEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQF 1556
E+I L QL++ G+ I + + + R ++ + + +L +++ Q F
Sbjct: 1224 NGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHF 1283
Query: 1557 SRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVID 1616
+D E++ WI EK+ TA D SY + N+ +K QKHQAF AEL AN D + V
Sbjct: 1284 LQDCHELKLWIDEKMLTAQDVSYDEARNLH-----TKWQKHQAFMAELAANKDWLDKVDK 1338
Query: 1617 MGNSL-IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675
G L +E+ V +L L +W L + K++ L +AN+ + F
Sbjct: 1339 EGRELTLEKPELKA---LVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCAL 1395
Query: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAF 1735
+ WL ++A L S+DYGKDL SVN LLKK Q+LE +++ E ++ + +QA +L
Sbjct: 1396 ESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ- 1454
Query: 1736 DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSE 1795
+V+ + +F+ + R +L S HQF RD++DE W+ E+ + S
Sbjct: 1455 GAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSM 1514
Query: 1796 DYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVE 1855
++G+DL VQ L KK++ L+ E+ HEP I + + + L G LA+ E
Sbjct: 1515 EHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL------GAAAAGPELAELQE 1568
Query: 1856 HWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLL 1914
WK L RG+RLE++L QQF + E EAW+ E ++ ++ E D L+A Q +
Sbjct: 1569 MWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA-QAEV 1627
Query: 1915 KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRK 1974
KKH+ E + ++ + + QD+I + IS + ++ + L++ A +R+
Sbjct: 1628 KKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERR 1687
Query: 1975 AKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 2034
+L E+ Q + D +E WI E+E + + G+D V L K F
Sbjct: 1688 ERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIG 1747
Query: 2035 QEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKV 2094
QE + + AL + L+A H + SL + W+ LL R + L A R
Sbjct: 1748 QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQR-- 1805
Query: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQ 2154
FL A++A A ++ ++ L D L +AL+ H A+ + + Q
Sbjct: 1806 ---FLHGARQALA---RVQHKQQQLPDGTG-RDLNAAEALQRRHCAYEHDIQALSPQVQQ 1858
Query: 2155 LAELDRQI-KSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQ 2213
+ + ++ K++ M+A+ E W LQ R Q + DK R
Sbjct: 1859 VQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAAR------RQLLLDTTDKFR- 1911
Query: 2214 EFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDL 2273
F + W+ E +D + + + ++ + EI A + D+
Sbjct: 1912 -FFKAVRELMLWMDEVNLQ-MDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDM 1969
Query: 2274 GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQ 2315
G +E L + E + ++L QL R Q E+
Sbjct: 1970 G---KELLARSHYAAEEIS-------EKLSQLQARRQETAEK 2001
Score = 521 bits (1341), Expect = e-147
Identities = 384/1412 (27%), Positives = 668/1412 (47%), Gaps = 75/1412 (5%)
Query: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASDE 70
A R ++ ++ R + L+ R Q+L + FQ DA ++E W+ + L+ ++S E
Sbjct: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE 774
Query: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
D + Q ++H+A E E++++ + L E + E ++ R+ L R
Sbjct: 775 LGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERH 833
Query: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
+E L + E+ L A L L E W+ +KE + L + LE +EV+Q++
Sbjct: 834 YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQR 893
Query: 191 FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK 250
FE + +M ++ VN A +L++ P ++ I Q+++N WQ+ + LA ++
Sbjct: 894 FETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAA 953
Query: 251 LFGAAEVQRFNRDVDETISWIKEKEQLMASDD-FGRDLASVQALLRKHEGLERDLAALED 309
L A +Q ++ + ET +W++EK +++ S G DLA V AL RK G ERDL A+
Sbjct: 954 LTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAA 1013
Query: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
+V L EA+ L HP A I + E+ T WE +R R L ++ RLQ FL
Sbjct: 1014 RVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRS 1073
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
D +W+ + + ++E + + AEALL +H +GE++ + + G+ +
Sbjct: 1074 LDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR 1133
Query: 430 AGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
A + +R++L L L +WE R+ + Q Q F RD Q + +S Q
Sbjct: 1134 --DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQ 1191
Query: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
E L + ++ +L + +A +KK EDF ++ A E+I L E +L+ + + +
Sbjct: 1192 EYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251
Query: 547 RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606
+ D++ R + A + +L D+ Q F +D ELK W++EKM TA D +Y + N
Sbjct: 1252 KADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARN 1311
Query: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
L K QKHQAF AEL+AN+ +D ++K G++L K V+ ++ ++ W +L
Sbjct: 1312 LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETT 1371
Query: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
T+ K L +AN+ + F ++ +E WL ++ L SDDYGKDLT+V L KK +LE +
Sbjct: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWE 1431
Query: 727 VAAHQDRIDGITIQARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
+A + ++ I QA+ +D G A +++ A+ ++ AL +PM R ++L S
Sbjct: 1432 MAVREKEVEAIQAQAKALAQEDQG---AGEVERTSRAVEEKFRALCQPMRERCRRLQASR 1488
Query: 785 RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT 844
Q RDVEDE W+ E+ P+A+S GKDL VQ L+KK+Q LQ EI GHEPRI +
Sbjct: 1489 EQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR 1548
Query: 845 QKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAES 904
++ A+ A +L EL + W+ L + R + LED+L+AQQ++ DA EAE+
Sbjct: 1549 ERQRAL------GAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEA 1602
Query: 905 WMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
WM E+E + + KDE SA+A +KKH+ L L+ Y +I L +Q P
Sbjct: 1603 WMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHP-- 1660
Query: 965 DETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYV--K 1022
+ T + A D +E+ ++ + L + E++D + ++ V
Sbjct: 1661 ESTRISIRQAQVDKLYAGLKELAGERRE--RLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718
Query: 1023 KLDPAQSASRENLLEE------QGSIALRQEQIDNQTRITKE--AGSVSLRMKQVE---- 1070
+ Q +L + + + + QE++D+ + AG + R E
Sbjct: 1719 SHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDS 1778
Query: 1071 --ELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128
E + LLEL + R +L + + A + + K+ L + G DL E
Sbjct: 1779 LNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEA 1837
Query: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
LQ++ ++ D++A ++ + ++ +G ++ A + E G
Sbjct: 1838 LQRRHCAYEHDIQA-------LSPQVQQVQDDGHRLQKAYAGDKAEEIG----------- 1879
Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248
++ + E W LQ + R QLL + RF + E W
Sbjct: 1880 -----------------RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLW 1922
Query: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE 1308
++E N ++ D++S + + +G + ++ A D+ +S + + L+ +AE
Sbjct: 1923 MDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAE 1982
Query: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
++ EK ++L ++ ++ L ++ F D +W+ LV S EL
Sbjct: 1983 EISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELG 2042
Query: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
V E+L++RH+ + A F A E+
Sbjct: 2043 CTVDEVESLIKRHEAFQKSAVAWEERFCALEK 2074
Score = 499 bits (1284), Expect = e-140
Identities = 394/1525 (25%), Positives = 705/1525 (46%), Gaps = 97/1525 (6%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI-ASDENYK 73
+ ER ++ Y EL+ RR +LE+S R F + E E W++E+ + AS + +
Sbjct: 612 VSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR 671
Query: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
D T L KH A E+ G + E G +++EGH + R EL QWE
Sbjct: 672 DLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWER 731
Query: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
L E+ +L QA L Q+ + D+ W+ D +V+S ELG D + L ++
Sbjct: 732 LEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRA 791
Query: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
+ ++ +H ++ + + AA L E ++ + + ++ L+ A +R L
Sbjct: 792 LEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERHYEELQARAGERARALEA 850
Query: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
A + + W++EKEQ + L ++ + ++ E LE ++ L ++ A
Sbjct: 851 ALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITA 910
Query: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
+ A++L +++P +I +E+L W+Q R LA + A L + +Q + + +
Sbjct: 911 VNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTET 970
Query: 374 TSWVTEMKALINADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
+W+ E +I + + L +D+AG AL + + +++A AL AAGH
Sbjct: 971 QAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANAL-AAGH 1029
Query: 433 YA-----SDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487
A + +RE T + RA + R + + LQ F R + W+ + +
Sbjct: 1030 PAQAVAINARLREVQTGWEDLRATMRR----REESLGEARRLQDFLRSLDDFQAWLGRTQ 1085
Query: 488 AFLLNEDLGDSLDSVEALLKKHEDFEKSLS-AQEE--KITALDEFATKLIQNNHYAMEDV 544
+ +E+ +L EALL +H + AQ E ++ AL E T+ + +
Sbjct: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF--L 1143
Query: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP 604
R +AL + L R+ +LA + Q F RD+ + + ++ + + P
Sbjct: 1144 RQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM--P 1201
Query: 605 SNLQGK---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWK 661
LQ ++K + F + + AN RI L +AG++L+ + D++ + + + K
Sbjct: 1202 GTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHK 1261
Query: 662 KLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKH 720
K +A + +LR+ +QQ F ++ +++LW+ E L + D D N+ +KH
Sbjct: 1262 KNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKM--LTAQDVSYDEARNLHTKWQKH 1319
Query: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
A++AA++D +D + + R+ + +K L R++ L+ A+ + L
Sbjct: 1320 QAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379
Query: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
D+ R + + E+W+ + S + GKDL V LLKK Q L+ E+A E +
Sbjct: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
+A+ + A+ +E A E V+ + +K+ AL +R + L+ S + Q+ D
Sbjct: 1440 EAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVE 1498
Query: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
+ W+ E+ P+ S ++GKD S + L+KK++ L ++ + I LRE+ ++
Sbjct: 1499 DEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAA 1558
Query: 961 APTD--------DETGKELVL----------ALYDYQEKSPREVTMKKGDILTLLNSTNK 1002
A + G EL L A Y++ + E M + ++ + K
Sbjct: 1559 AGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAK 1618
Query: 1003 DWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSV 1062
D + A VKK + A + A Q+ ID++ E+ +
Sbjct: 1619 DELSAQ----------AEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEH---PESTRI 1665
Query: 1063 SLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGAD 1122
S+R QV++LY L EL +R+ L++ + L RE ++L+QWI E+E S E+G D
Sbjct: 1666 SIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQD 1725
Query: 1123 LEQVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPR 1181
E V +L+ KF +F +D + R+ N +A L + G A
Sbjct: 1726 YEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA--------------- 1770
Query: 1182 DETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRD 1241
T + WK + LNE W L +L + R Q+L +A+E+QRF
Sbjct: 1771 ------TVAEWKDS---------------LNEAWADLLELLDTRGQVLAAAYELQRFLHG 1809
Query: 1242 ADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQ 1301
A + ++ K Q L D G DL + +ALQR+H +E D+ AL +V + + RL +
Sbjct: 1810 ARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK 1868
Query: 1302 SHP-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRG 1360
++ + AE++ + +AW+ L + R+ L D+ D RF R+LM W++ +
Sbjct: 1869 AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNL 1928
Query: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKL 1420
+ + E +DV+ A+ +++ Q + EI+ARA F + G++LLA HYA+ EI +KL
Sbjct: 1929 QMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKL 1988
Query: 1421 DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
L R + + W ++ L LE+ +F RD AE W+ ++E + + + G ++D V
Sbjct: 1989 SQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEV 2048
Query: 1481 EALIKKHEDFDKAINVQEEKIAALQ 1505
E+LIK+HE F K+ EE+ AL+
Sbjct: 2049 ESLIKRHEAFQKSAVAWEERFCALE 2073
Score = 446 bits (1146), Expect = e-124
Identities = 399/1724 (23%), Positives = 756/1724 (43%), Gaps = 113/1724 (6%)
Query: 35 LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYK-DPTNLQGKLQKHQAFEAEVQ 93
+R++KLE F R A E W+ E ++ S +N+ + ++ ++KH+A E ++
Sbjct: 418 IRQEKLEQLAAR--FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIV 475
Query: 94 ANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ 153
A SG + +D + +E + + I R + R W+ L + + + +LL +L +
Sbjct: 476 AYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQK 535
Query: 154 YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAA 213
++ +MDW+ + + + S++LG+ L VE L + E + D+A ERV V+ A
Sbjct: 536 VFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASAL 595
Query: 214 KLI---QEQHP-EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS 269
+ +E P + +L+ + ++ +++ L LA R+ +L + + RF +V E +
Sbjct: 596 RFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEA 655
Query: 270 WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL-QQSHPLS 328
W++E++ L+AS D GRDL LL KH L +++ +K + +L + HP
Sbjct: 656 WVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHP-G 714
Query: 329 ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
A+Q + EL WE++ LA ER RL + L +F AD D+ +W+ + L+++ E
Sbjct: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE 774
Query: 389 LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEE 448
L D +AL +H+ + EI +H + + E A L + EV+ ++ L
Sbjct: 775 LGHDEFSTQALARQHRALEEEIRSHRPTLDALREQA-AALPPTLSRTPEVQGRVPTLERH 833
Query: 449 RAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKK 508
L R + E + L + W+ ++E +L L + L+ +E + ++
Sbjct: 834 YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQR 893
Query: 509 HEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQ 568
E E ++ +ITA+++ A +L++ N + + ++ L R A ++A
Sbjct: 894 FETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAA 953
Query: 569 LADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKDPSNLQGKVQKHQAFEAELSANQS 626
L + +Q + + E ++W+ EK K +T D + + +K E +L A +
Sbjct: 954 LTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAA 1013
Query: 627 RIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN 686
R+ L + L + + AR+ EV + W+ L + L EA + Q F R+
Sbjct: 1014 RVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRS 1073
Query: 687 VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF-Q 745
++D + WL + +AS++ L + L +HA L +V Q + + +
Sbjct: 1074 LDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR 1133
Query: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
D ++++ EAL +E L +R+ +LA + Q RD E + +E
Sbjct: 1134 DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEY 1193
Query: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
+ + T L +KK + + + + RI + + G +V EG+ A+ ++ K
Sbjct: 1194 VLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKA 1253
Query: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDE-DS 924
+ ++ + + A Q L D+ + Q + D +E + W+ EK ++ + D DE +
Sbjct: 1254 DSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEK--MLTAQDVSYDEARN 1311
Query: 925 AEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVL----------- 973
+KH+A M++L+A + + D+ G+EL L
Sbjct: 1312 LHTKWQKHQAFMAELAANKDWLDKV---------------DKEGRELTLEKPELKALVSE 1356
Query: 974 ALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA--AYVKKLDPAQSAS 1031
L D + T + +L ++ + + + ++ + A + D + +
Sbjct: 1357 KLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416
Query: 1032 RENLLEE-----QGSIALRQEQIDNQTRITKE-------AGSVSLRMKQVEELYHSLLEL 1079
N+L + + +A+R+++++ K AG V + VEE + +L +
Sbjct: 1417 SVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQP 1476
Query: 1080 GEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKD 1139
+R L+ S ++ R+ + W+ E+ +S E G DL V++L KK QK+
Sbjct: 1477 MRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKE 1536
Query: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
++ +E R+ D+ ++Q G + A P
Sbjct: 1537 IQGHEPRIADLR-------------------ERQRALG--------AAAAGP-------- 1561
Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
+ EL E W+ L E R + L A Q+F+RDA E + W+ E+ +
Sbjct: 1562 -------ELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQ 1614
Query: 1260 NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELN 1318
D S QA +KH+ E+ LA ++ L +++ +I HPES + + +++
Sbjct: 1615 EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTR-ISIRQAQVD 1673
Query: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
+ ++ L + A +R+ +L + L + + DL WI + +S EL +D L
Sbjct: 1674 KLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLR 1733
Query: 1379 ERHQE-HRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQR 1437
++ +E R + L+A GH A + + D L++ ADL + R
Sbjct: 1734 DKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793
Query: 1438 RMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ 1497
+L ELQ F QA + ++ L + G L++ EAL ++H ++ I
Sbjct: 1794 GQVLAAAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQAL 1852
Query: 1498 EEKIAALQAFADQL--IAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQ 1555
++ +Q +L AG A+ +I V + W +L+ +R L ++ +
Sbjct: 1853 SPQVQQVQDDGHRLQKAYAGDKAE-EIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFR 1911
Query: 1556 FSRDVDEIEAWISE-KLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGV 1614
F + V E+ W+ E LQ + E P ++ + L+ K+Q Q +AE+ A ADR
Sbjct: 1912 FFKAVRELMLWMDEVNLQMDAQER---PRDVSSADLVIKNQ--QGIKAEIEARADRFSSC 1966
Query: 1615 IDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKD 1674
IDMG L+ R A E + +L+ L + Q +K EK L+ + F
Sbjct: 1967 IDMGKELLARSHYAAEE--ISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGM 2024
Query: 1675 FDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1718
+ WL E L+ S + G + V +L+K+H+ + A E+R
Sbjct: 2025 AEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEER 2068
Score = 437 bits (1123), Expect = e-122
Identities = 421/1888 (22%), Positives = 807/1888 (42%), Gaps = 121/1888 (6%)
Query: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQ--RQGKLFGAAE-----VQRFNRDVDETI 268
+ P+E+ I T + ++K LA++ R GK+ A V+++ E +
Sbjct: 259 VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELL 318
Query: 269 SWIKEKEQLMASDDFGRDLASVQALLRKHEG---------------LERDLAALEDKVKA 313
WI++ + L+ VQ L+ LE L ++ K++A
Sbjct: 319 QWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRA 378
Query: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY----RLQRFLAD 369
+ ++ +S ++ WE++ ER L +L++ A
Sbjct: 379 NNQKVYTPREGRLIS---------DINKAWERLEKAEHERELALRTELIRQEKLEQLAAR 429
Query: 370 FRDLTS----WVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
F + W++E + L++ D ++A EA + +H+ + +I A+ ++ D
Sbjct: 430 FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAA 489
Query: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
L A ++ + + ++ L ++ RR++ ++LQ ++D + +WM +
Sbjct: 490 ELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEE 549
Query: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ-NNHYAMED- 543
+ L ++DLG L VE LL+ HE E ++ Q E++ A+ A + Y D
Sbjct: 550 MKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDP 609
Query: 544 --VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT-ATDEA 600
V+ R L AL E A RRA+L +S L +F + E ++WV E+ A+ +
Sbjct: 610 QLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADT 669
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
+D + + KH A E+S + + GQ+L+ H + +AR E+ + W
Sbjct: 670 GRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW 729
Query: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
++L E + +L +A QF + D+E WL + ++S + G D + Q L ++H
Sbjct: 730 ERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQH 789
Query: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
LE ++ +H+ +D + QA E ++ + L YE L+ R + L
Sbjct: 790 RALEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERHYEELQARAGERARAL 848
Query: 781 ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
+L L + + W+ EKE + L ++ + ++ + L+ E+ +I
Sbjct: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
AV +++ + + +LN +W+ + A ++ L +L Q Y +
Sbjct: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968
Query: 901 EAESWMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-- 957
E ++WMREK ++ ST G D AL +K DL A + + L +A +
Sbjct: 969 ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
Query: 958 ---QQVAPT----DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE-- 1008
Q VA + +TG E + A +E+S E + D L L+ + +
Sbjct: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQ-DFLRSLDDFQAWLGRTQTA 1087
Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ 1068
V +G + L +A R + Q + + + TR + + LR +
Sbjct: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQR- 1146
Query: 1069 VEELYHSLLELG---EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQ 1125
+E L ELG E R+G L ++ R+A + + ++ +E L+ E+ L+
Sbjct: 1147 LEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQA 1206
Query: 1126 VEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETD 1185
+ KK +DF + AN R+ + + L SEG ++ R++ D
Sbjct: 1207 ADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEG------------NIHADKIREKAD 1254
Query: 1186 SKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADET 1245
S + R + Q A++ L E Q F +D E
Sbjct: 1255 S------------------------IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHEL 1290
Query: 1246 KEWIEEKNQALNTDNYGHDLA-SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP 1304
K WI+EK L + +D A ++ +KH+ F +LAA D ++ + + L P
Sbjct: 1291 KLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP 1348
Query: 1305 ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSS 1364
E + EK +L++ W L + L D++ + F L SW+ ++ + S
Sbjct: 1349 ELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS 1408
Query: 1365 DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILD 1424
D+ KD+T LL++ Q E+ R +A Q + LA + E+++ ++
Sbjct: 1409 DDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAI-QAQAKALAQEDQGAGEVERTSRAVE 1467
Query: 1425 QERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALI 1484
++ L + +R L E FHRD E W+ R ++ + G L SV+ L+
Sbjct: 1468 EKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLM 1527
Query: 1485 KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKR 1544
KK++ K I E +IA L+ ++ A G A G + E+ + W+RL ++ +
Sbjct: 1528 KKNQTLQKEIQGHEPRIADLR---ERQRALGAAAAGPELA---ELQEMWKRLGHELELRG 1581
Query: 1545 SKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQLSKLLSKHQKHQAFEAE 1603
+L ++ QQF RD E EAW+ E+ L E KD + Q ++ +KHQ E
Sbjct: 1582 KRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQ-----AEVKKHQVLEQA 1636
Query: 1604 LHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
L A I + +I+ + + R A + + L + + E+ ++L+E
Sbjct: 1637 LADYAQTIHQLAASSQDMIDHEHPESTR--ISIRQAQVDKLYAGLKELAGERRERLQEHL 1694
Query: 1664 KQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISA-HEDRLKDL 1722
+ + D + W+ E E + AS + G+D V L K + D S ++R+
Sbjct: 1695 RLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSA 1754
Query: 1723 NSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEE 1782
N+ A+ L+ + V + +D++N + + + +R L ++ L +F
Sbjct: 1755 NALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQAL 1814
Query: 1783 SWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIG 1842
+ ++ K+ + + GRDL + L+++H E ++ A P +Q V D G +L
Sbjct: 1815 ARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873
Query: 1843 K-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASE 1901
K EEI + + E W +L+ +AAR Q L ++ + +F V E W++E + ++
Sbjct: 1874 KAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQ 1933
Query: 1902 DYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNG 1961
+ +++ ++K + + + DR + G++L+ ++++ E IS K+ L
Sbjct: 1934 ERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQA 1993
Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
+ + + ++ L L F A + E+W+ +E +++ + G + V++L+
Sbjct: 1994 RRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIK 2053
Query: 2022 KQETFDAGLQAFQQE--GIANITALKDQ 2047
+ E F A+++ + +TAL+++
Sbjct: 2054 RHEAFQKSAVAWEERFCALEKLTALEER 2081
Score = 318 bits (814), Expect = 5e-86
Identities = 277/1205 (22%), Positives = 530/1205 (43%), Gaps = 43/1205 (3%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72
I ++Q+ R+ +F+ L+ ++ L + Q + + E + W++EK ++
Sbjct: 929 IVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLG 988
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
D + +K E +++A + + +L N + + + I RL E+ WE
Sbjct: 989 NDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWE 1048
Query: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFE 192
L MR + L +A++L +LR +D W+ + V SEE L E L +
Sbjct: 1049 DLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHA 1108
Query: 193 EFQTDMAAHEERVNEVNQFAAKLIQEQ-HPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
+ ++ + + + ++ ++Q P+ ++ + + + W+ L + RQG+L
Sbjct: 1109 ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
Query: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKV 311
A Q F RD + + +E +++ + L + A ++K E + A +++
Sbjct: 1169 AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERI 1228
Query: 312 KALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFR 371
L +L + A +I+ K + + ++ + A + RL D+ Q FL D
Sbjct: 1229 HGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCH 1288
Query: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAG 431
+L W+ E K L D + +HQ E+ A++D D+ G+ L
Sbjct: 1289 ELKLWIDE-KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK 1347
Query: 432 HYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLL 491
V EKL L L + + + +LF + +++W+ +A L
Sbjct: 1348 PELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLH 1407
Query: 492 NEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDAL 551
++D G L SV LLKK + E ++ +E+++ A+ A L Q + A E T R A+
Sbjct: 1408 SDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSR-AV 1466
Query: 552 LSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSNLQGK 610
+ AL + R +L S QF RD ++ WV E++ A+ E KD ++Q
Sbjct: 1467 EEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526
Query: 611 VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELK 670
++K+Q + E+ ++ RI L + + L + E+ +WK+L EL+
Sbjct: 1527 MKKNQTLQKEIQGHEPRIADLRERQRAL------GAAAAGPELAELQEMWKRLGHELELR 1580
Query: 671 GIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAH 730
G +L +A + QQF R+ + E W+ E E H+ + KD + Q KKH +LE +A +
Sbjct: 1581 GKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640
Query: 731 QDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLF 790
I + ++ D H ++ I +Q + Y LKE R+++L + LRL QL
Sbjct: 1641 AQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLR 1700
Query: 791 RDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA--GHEPRIKAVTQKGN 848
R+++D E WI+E+E +AAS G+D V L K + + + G E R+ + N
Sbjct: 1701 RELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQE-RVDSANALAN 1759
Query: 849 AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
++ GH A V LN+ W L R Q L + + Q++ A +A + ++
Sbjct: 1760 GLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQH 1819
Query: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD-DET 967
K+ + G+D ++AEAL ++H A D+ A +Q +++ ++ A +E
Sbjct: 1820 KQQQLPDGT-GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEI 1878
Query: 968 GKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK---KL 1024
G+ + + + ++ LL++T+K + V + ++ ++ +
Sbjct: 1879 GRHMQAVAEAWAQLQGSSAARRQ----LLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQE 1934
Query: 1025 DPAQSASRENLLEEQ----GSIALRQEQIDNQTRITKE--------AGSVSLRMKQVEEL 1072
P +S + +++ Q I R ++ + + KE A +S ++ Q++
Sbjct: 1935 RPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQAR 1994
Query: 1073 YHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKK 1132
E +++ L+ + + R+A + W+ +E + S E+G +++VE L K+
Sbjct: 1995 RQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKR 2054
Query: 1133 FDDFQKDLKANESRLKDINKVA--EDLESEGLMAEEVQAVQQQ-----EVYGMMPRDETD 1185
+ FQK A E R + K+ E+ E E E + ++Q + P D
Sbjct: 2055 HEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVG 2114
Query: 1186 SKTAS 1190
+TAS
Sbjct: 2115 GQTAS 2119
Score = 277 bits (708), Expect = 1e-73
Identities = 296/1437 (20%), Positives = 593/1437 (41%), Gaps = 133/1437 (9%)
Query: 1054 RITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
R+ + R+++ E L R+ LE+ +F R+A + W++E +
Sbjct: 390 RLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFD--RKAAMRETWLSENQRL 447
Query: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
++ + G +L VE +K + + D+ A R++ ++ VA +L +E + A +Q
Sbjct: 448 VSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQH 507
Query: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
V ARL W L+Q+ R + L
Sbjct: 508 NV-------------------ARL-----------------WDFLRQMVAARRERLLLNL 531
Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
E+Q+ +D +W+EE L + + G LA V+ L + HE E D+A ++V ++
Sbjct: 532 ELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVS 591
Query: 1294 ETAERLI----QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFR 1349
+A R + P + + E+ +L Q++ +L + A R+A+L +S L RFL +
Sbjct: 592 ASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVG 651
Query: 1350 DLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHG 1409
+ +W+ + L++S + +D+TGA LL +H R E+ R G + + GQQL+A G
Sbjct: 652 EAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEG 711
Query: 1410 HYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLN 1469
H + + + L + LE +R L Q L F D E W+ ++
Sbjct: 712 HPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVS 771
Query: 1470 TEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEV 1529
+ + G S +AL ++H ++ I + AL+ A L ++ R +
Sbjct: 772 SPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTP-EVQGRVPTL 830
Query: 1530 LDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSK 1589
+ L+A+ E+ L + L + W+ EK Q + + + +L
Sbjct: 831 ERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPE----RLED 886
Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLV 1649
L Q+ + E E++ A +I V D+ L++ A +D + L +WQ
Sbjct: 887 LEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK--ANPPGKDRIVNTQEQLNHRWQQFR 944
Query: 1650 QKSAEKSQKLKEANKQQNFNTGIKDFDFWLSE-VEALLASEDYGKDLASVNNLLKKHQLL 1708
+ + K L A QN++ + W+ E + + +++ G DLA V L +K
Sbjct: 945 RLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGT 1004
Query: 1709 EADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNES 1768
E D+ A R+ +L +A++L + + + ++ +++ R L E+
Sbjct: 1005 ERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEA 1064
Query: 1769 HRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGV 1828
RL F R +DD ++W+ + V SE+ L + L +H L E+ + +
Sbjct: 1065 RRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL 1124
Query: 1829 LDTGKKLSDDNTIGK-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
G++++ D + ++QRL W+EL ++ +R RL ++ +Q F+ + +
Sbjct: 1125 RALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA 1184
Query: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH 1947
E ++ + +++ + TL A +KK E F + + +R++ + G+ L+ + N
Sbjct: 1185 EGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNI 1244
Query: 1948 HEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTD 2007
H + I K + + + AA Q +L +N F ++ WI EK + +
Sbjct: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDV 1304
Query: 2008 DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLM 2067
Y + ++ T K + F A L A ++ + + +L K + + L
Sbjct: 1305 SYD-EARNLHTKWQKHQAFMAELAA-NKDWLDKVDKEGRELTLEKPELKALVSEKLRDLH 1362
Query: 2068 KRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDL------TD 2121
+RW +L + A+ + L +A + E FA+ A SW E+ + L D
Sbjct: 1363 RRWDELETTTQAKARSLFDA----NRAE----LFAQSCCALESWLESLQAQLHSDDYGKD 1414
Query: 2122 PVRCNSLEEIKALREAHDAFR-SSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEAL 2180
N L + + + E A R + + QA LA+ D+ T A+
Sbjct: 1415 LTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVE--------RTSRAV 1466
Query: 2181 EETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTY-------- 2232
EE +R L + ++ER LQ + + + + + E W+ E
Sbjct: 1467 EEKFRALCQPMRERCRRLQASREQHQFHRDVEDEIL--------WVTERLPMASSMEHGK 1518
Query: 2233 -LLDGSCMVEESGTLESQLEATKRKHQEIR---------AMRSQLKKIEDL--------- 2273
L +++++ TL+ +++ + + ++R A +L +++++
Sbjct: 1519 DLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELE 1578
Query: 2274 --GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQAR---NTTGVTEE 2328
G +E+AL Y + + A+ W +L M Q + ++ A+ V E+
Sbjct: 1579 LRGKRLEDALRAQQFYRDAAE---AEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQ 1635
Query: 2329 ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRD 2388
AL +++ ++H+ +S S + + + D + + + R+
Sbjct: 1636 ALADYAQTIHQLAASSQDMIDHEHPESTRIS-------IRQAQVDKLYAGLKELAGERRE 1688
Query: 2389 GHVSLQEYMAF-MISRETENVK---SSEEIESAFRALSSEGKPYVTKEELYQNLTRE 2441
LQE++ + RE ++++ E+ +A L + + + ++ +R+
Sbjct: 1689 ---RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRD 1742
Score = 85.5 bits (210), Expect = 6e-16
Identities = 62/225 (27%), Positives = 113/225 (50%), Gaps = 6/225 (2%)
Query: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY-RFQFFQRDAEELEKWIQE-KLQIA 67
+ AE+I Q V + + + + S RRQ L D+ +F+FF+ EL W+ E LQ+
Sbjct: 1873 DKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA-VRELMLWMDEVNLQMD 1931
Query: 68 SDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMEL 127
+ E +D ++ ++ Q +AE++A + + G +++ H+A+E I +L +L
Sbjct: 1932 AQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQL 1991
Query: 128 HRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVL 187
+ + EK +EK L +++ + R+ W+ +E +V S ELG ++ VE L
Sbjct: 1992 QARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESL 2051
Query: 188 QKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDE 232
K+ E FQ A EER + + A E+ +E K +++E
Sbjct: 2052 IKRHEAFQKSAVAWEERFCALEKLTA---LEEREKERKRKREEEE 2093
Score = 56.2 bits (134), Expect = 4e-07
Identities = 60/253 (23%), Positives = 105/253 (41%), Gaps = 19/253 (7%)
Query: 2078 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2137
A K++ + H + E L + AS W E L D NSL ++ ++
Sbjct: 287 AVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQS 346
Query: 2138 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASNPYTWFTMEA-----LEETWRNLQKII 2191
+++R+ + + L L I+S A+N + E + + W L+K
Sbjct: 347 FNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAE 406
Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2251
EREL L+ E RQE+ ++L F + A W+ E + + + G + +E
Sbjct: 407 HERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-----DNFGLELAAVE 461
Query: 2252 ATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQL-- 2305
A RKH+ +I A +++ ++ + A + D K +A+ WD L Q+
Sbjct: 462 AAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521
Query: 2306 --GMRMQHNLEQQ 2316
R+ NLE Q
Sbjct: 522 ARRERLLLNLELQ 534
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 433 bits (1114), Expect = e-121
Identities = 356/1412 (25%), Positives = 621/1412 (43%), Gaps = 102/1412 (7%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73
+ ER R+ R +E + R ++L+++ F D + L W+++ ++A+ ++
Sbjct: 744 LAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGH 803
Query: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDE----------TGNLMISEGHFASETIRTR 123
D + + ++H+A EV+A+ G + L G L+++ ++ R
Sbjct: 804 DEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVA--------LQVR 855
Query: 124 LMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEH 183
++E + + + E + L A + + E WI +KE + S + L+
Sbjct: 856 VVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDD 915
Query: 184 VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGL 243
VEV+Q +FE +M + RV +VN +L++ HP + +++ QD +N+ W R+ L
Sbjct: 916 VEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVEL 975
Query: 244 ALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERD 303
QR+ ++ V+ +V E + ++EK + + S + AL + GLE
Sbjct: 976 VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAP-----RAGGALQWRLSGLEAA 1030
Query: 304 LAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
L ALE + AL EA L + P A ++ EEL W + + A + + RL
Sbjct: 1031 LQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRL 1090
Query: 364 QRFLADFRDLTSWVTEMKALINADE--LASDVAGAEALLDRHQEHKGEIDAHEDSFKSAD 421
QRFL D W+ + E L + + A+ALL RH K E+D E+ +
Sbjct: 1091 QRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIV 1150
Query: 422 ESGQALLAAGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQ 478
+ +ALLAA + E L L LL LWE RR+ Q QLF RD Q
Sbjct: 1151 AASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQ 1210
Query: 479 VDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH 538
+ QE L +L +++SVE LK+H DF ++ ++K+ + A L++ +
Sbjct: 1211 ALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGN 1270
Query: 539 YAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD 598
E LL + RA + +L D LQ F RD EL W++EKM A D
Sbjct: 1271 IYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARD 1330
Query: 599 EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVIS 658
+D L + +HQAF AEL+ N+ ++ +E+ GQ+L+ V ++ E+
Sbjct: 1331 GTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
Query: 659 LWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQK 718
W +L T+ K +L EA++ Q ++ +++ L +E L D G DL V + K
Sbjct: 1391 CWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLK 1450
Query: 719 KHALLEADVAAHQDRIDGITIQ--ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVAR 776
K +E+ V + + Q A + A E + ++Q A+ R L EP+ R
Sbjct: 1451 KLQSMESQVEEWYREVGELQAQTAALPLEPASK---ELVGERQNAVGERLVRLLEPLQER 1507
Query: 777 KQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGH 836
++ L S L Q+ D++DE W++E+ P+A T RG L VQ +KK+Q L+ EI H
Sbjct: 1508 RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 1567
Query: 837 EPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYF 896
PR++ V ++ A+ AE V+ L +L W L+ A +R+Q L+ + Q +QY+
Sbjct: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
Query: 897 ADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC 956
D E E+W+ E+E ++ S D GKDE S LLKKH L + Y SI L Q ++
Sbjct: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
Query: 957 RQQVAPTDDETGK------ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVN 1010
+ P ++ + L +AL + E+ R V +++ L L+ +V+
Sbjct: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLYQLSR--------QVS 1737
Query: 1011 DRQGFVPAAYVKKLDP--AQSASRENLLEEQGS-------------IALRQEQIDNQTRI 1055
+ + ++ V P Q ++L+E+ S +A + +D
Sbjct: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
Query: 1056 TKEAGSVSLRMKQ-VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
A + K + E + LLEL R +L S + F +A ELQ I EK L
Sbjct: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
Query: 1115 TSEEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
+ +Q+ F+ DL+ S+++ + + A L + E +A+ +
Sbjct: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTV-YAGEHAEAIASR 1916
Query: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
E +E+ + W+ L E+ + S
Sbjct: 1917 E----------------------------------QEVLQGWKELLSACEDARLHVSSTA 1942
Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
+ RFH + W++ + + D++SV+ L H+G + +L A ++ +
Sbjct: 1943 DALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQ 2002
Query: 1294 ETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMS 1353
E L+ + A+++Q + +L + ++ D+ L ++ +F + +
Sbjct: 2003 ELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA 2062
Query: 1354 WINGIRGLVSSDELAKDVTGAEALLERHQEHR 1385
W+ L+ S EL V E L+ RH+ R
Sbjct: 2063 WLTAQEPLLQSRELGSSVDEVEQLIRRHEAFR 2094
Score = 413 bits (1062), Expect = e-115
Identities = 421/1813 (23%), Positives = 768/1813 (42%), Gaps = 177/1813 (9%)
Query: 584 ELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNH 643
EL +W++ + +++ + + +L G Q+ QAF A + + + EK +++ +
Sbjct: 320 ELLAWIHRTVGLISNQKFAN--SLSGVQQQLQAFTAYCTLEKP-VKFQEKGNLEVLLFSI 376
Query: 644 YAKDEVAAR----------MNEVISLWKKLLEATELKGIKLR-EANQQ-------QQFNR 685
+K R + ++ W +L +A + LR E +Q Q+F+
Sbjct: 377 QSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDH 436
Query: 686 NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745
V E WL E + ++ D++G +L V+ KKH +EAD+AA+++R+ G+ A+
Sbjct: 437 KVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALA 496
Query: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
G++D + ++++++ ++ L + AR+ +L +L LQ++F+++ W+ E +
Sbjct: 497 AEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQA 556
Query: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
S G+ L+ +LL+KH L+ +IA R++A+ + + D +
Sbjct: 557 QLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVIC 616
Query: 866 HELNQKWEAL---KAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIV--------- 913
+ +N L + +A++RR +LE S + EAESW R+KE ++
Sbjct: 617 NRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAA 676
Query: 914 ------GSTDYGKDEDSAEALLKKHEALMS-----------------DLSAYGSSIQ--- 947
G+ D S LL +H+ L +L A G ++
Sbjct: 677 GAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGA 736
Query: 948 ------ALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTN 1001
L E+A S R++ ++ + + + + R + D+ LL+
Sbjct: 737 DTVHLVGLAERAASARRRWQRLEEAAARR------ERRLQEARALHQFGADLDGLLDWL- 789
Query: 1002 KDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGS 1061
+D +++ G A+ ++L A + +G ++ + Q+ +
Sbjct: 790 RDAYRLAAAGDFGHDEASS-RRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPL 848
Query: 1062 V---SLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEE 1118
V +R+ + E+L+ + E+ R+ L + + +F E + + WI EKE L S
Sbjct: 849 VVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMR 908
Query: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGL-MAEEVQAVQQQEVYG 1177
V L+ VEV+Q +F+ +++ + R+ D+N ++L G ++EV++ Q
Sbjct: 909 VPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDH---- 964
Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQR 1237
LN RW + +L E+R + + + V+
Sbjct: 965 ---------------------------------LNSRWNRIVELVEQRKEEMSAVLLVEN 991
Query: 1238 FHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297
+ E + + EK +A+ + ALQ + G E L AL + +L E A
Sbjct: 992 HVLEVAEVRAQVREKRRAVESAPRAGG-----ALQWRLSGLEAALQALEPRQAALLEEAA 1046
Query: 1298 RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWING 1357
L + P A L + EL W +L A + + LQRFL D + W+
Sbjct: 1047 LLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVR 1106
Query: 1358 IRGLVSSDE--LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA-HGHYASP 1414
+ E L + A+ALL RH + E+D R + + LLA G P
Sbjct: 1107 AQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGP 1166
Query: 1415 --EIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED 1472
+ + L L+ L W RR L Q QLF RD QA + +E L+ +
Sbjct: 1167 GLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAE 1226
Query: 1473 KGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDR 1532
+++SVE +K+H DF + + ++K+ A+ L+ G+ +L++
Sbjct: 1227 LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEK 1286
Query: 1533 WRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLS 1592
+ + + + KL + LQ F RD E++ WI EK+ A D + +D KL
Sbjct: 1287 NQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDN-----HKLHK 1341
Query: 1593 KHQKHQAFEAELHANADRIRGVIDMGNSLI-ERGACAGSEDAVKARLAALADQWQFLVQK 1651
+ +HQAF AEL N + + + G L+ E+ A S V+ +L + W L
Sbjct: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS---VRKKLGEIRQCWAELEST 1398
Query: 1652 SAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEAD 1711
+ K+++L EA+K + D L +E+ L D G DLA+VN+ LKK Q +E+
Sbjct: 1399 TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQ 1458
Query: 1712 ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRL 1771
+ + +L +Q +L A V ++++ + R ++ RR L S L
Sbjct: 1459 VEEWYREVGELQAQTAALPLEPA-SKELVGERQNAVGERLVRLLEPLQERRRLLLASKEL 1517
Query: 1772 HQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDT 1831
HQ D+DDE +W++E+ L + G L VQ KK++ L E+ AH P ++ VL+
Sbjct: 1518 HQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 1577
Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWI 1891
L+ + E +++ L Q W L++ A R Q L+ + + +Q+ +V E EAW+
Sbjct: 1578 AGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
Query: 1892 NEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEEN 1951
E+ L+ SED G + LLKKH E +++ + + + L++ + E
Sbjct: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
Query: 1952 ISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGR 2011
IS + ++ L++ +R+ L++ Q + + +E WI EKE + + G+
Sbjct: 1698 ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQ 1757
Query: 2012 DLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWS 2071
D V L K F + +E +A + + D+L+ H + + L + W+
Sbjct: 1758 DFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWA 1817
Query: 2072 QLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEI 2131
+LL R +LL A K F A E R L
Sbjct: 1818 ELLELMGTR-AQLLAASRELHK-------FFSDARELQGQIEEKRR------RLPRLTTP 1863
Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
R + + + +L + + D L RQ++ A+ T + E E Q++
Sbjct: 1864 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ--EGAAQLRTVYAGEHAEAIASREQEV- 1920
Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLE---- 2247
L+ KE E+ +L A FH +++ ++ +DG + + G +
Sbjct: 1921 ----LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSW-MDG--IASQIGAADKPRD 1973
Query: 2248 -SQLEATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQL 2302
S +E HQ E+ A +L ++LG + +L NK + QL
Sbjct: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRS-----LLLNKSAMADEIQA-----QL 2023
Query: 2303 DQLGMRMQHNLEQ 2315
D+LG R + E+
Sbjct: 2024 DKLGTRKEEVSEK 2036
Score = 370 bits (949), Expect = e-101
Identities = 402/1874 (21%), Positives = 768/1874 (40%), Gaps = 152/1874 (8%)
Query: 363 LQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEID 411
++R+ +L +W+ LI+ + A+ ++G + L + KG ++
Sbjct: 311 IERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLE 370
Query: 412 AHEDSFKSADESGQALL-----AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQC 466
S +S + L G + D+ +L ER A L +R+++ E
Sbjct: 371 VLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLE-- 428
Query: 467 MDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL 526
+ Q F ++W+++ + + ++ G L +VEA +KKHE E ++A EE++ +
Sbjct: 429 LLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGV 488
Query: 527 DEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELK 586
E A L +Y + VA +RD++L + L RR +L + LQ+ F++ +
Sbjct: 489 AELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMV 548
Query: 587 SWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA 645
W+ E + + + E + +QKH E +++A R++AL A + + Y
Sbjct: 549 DWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQ 608
Query: 646 KDE---VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLA 702
+ + R+N V +L E + +L + + +E+ E W + E L
Sbjct: 609 PCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLE 668
Query: 703 SDDYG---------------KDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
+ G DL++ L +H +L+ ++ + + + A
Sbjct: 669 AAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAA 728
Query: 748 GH--------FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETW 799
G + ++ + R++ L+E R+++L ++ L Q D++ W
Sbjct: 729 GGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDW 788
Query: 800 IREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK----GNAMVEEGH 855
+R+ +AA+ + G D + L ++H+AL E+ H + + ++ G A
Sbjct: 789 LRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPL 848
Query: 856 FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGS 915
A ++ ++ E Q + + A+ RRQ L D+L + F + + E W+ EKE + S
Sbjct: 849 VVA--LQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLS 906
Query: 916 TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK------ 969
D E + + E+L ++++ + + Q + P+ DE
Sbjct: 907 MRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLN 966
Query: 970 ---ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDP 1026
++ L + +++ V + + +L + + +V +++ V +A P
Sbjct: 967 SRWNRIVELVEQRKEEMSAVLLVENHVLEVAEV------RAQVREKRRAVESA------P 1014
Query: 1027 AQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMK-QVEELYHSLLELGEKRKG 1085
+ + L G A Q Q + +EA ++ R Q L+ ELG +
Sbjct: 1015 RAGGALQWRLS--GLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGA 1072
Query: 1086 MLEKSCKKFMLFREANELQQWINEKEAALT----SEEVGADLEQVEVLQKKFDDFQKDLK 1141
+ + A LQ+++++ +A L ++E E L ++ L
Sbjct: 1073 LASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGP--LPNSLEEADALLA 1130
Query: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201
+ + +++++ ED +E + A E+ + DE W
Sbjct: 1131 RHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDE--------W--------- 1173
Query: 1202 VATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNY 1261
+ L W L L E R + L AH Q F RD + + + AL+
Sbjct: 1174 ------LPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAEL 1227
Query: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAW 1321
+ SV+ ++H F + K+ + AE L++ E QE T L +
Sbjct: 1228 PGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKN 1287
Query: 1322 SSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERH 1381
RA Q KL D +LQ FL D +L WI+ + L++ D +D RH
Sbjct: 1288 QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHE-KMLMARDGTREDNHKLHKRWLRH 1346
Query: 1382 QEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMML 1441
Q E+ + E+ GQQL+ + +++KL + Q A+LE + L
Sbjct: 1347 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 1406
Query: 1442 DQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKI 1501
+ + + + + + E+ L D G L +V + +KK + + + ++
Sbjct: 1407 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 1466
Query: 1502 AALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVD 1561
LQA L +K + R+N V +R RL + E+R L S+ L Q + D+D
Sbjct: 1467 GELQAQTAAL-PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLD 1525
Query: 1562 EIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSL 1621
+ AW+ E+L A + L + +K+Q E+ A+ R+ V++ +L
Sbjct: 1526 DELAWVQERLPLAMQTERGNG----LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 1581
Query: 1622 IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSE 1681
+ +AV+ L L W L + + + Q L A + + + + + + WL E
Sbjct: 1582 ASLRS--PEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 1639
Query: 1682 VEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVK 1741
E L+ SED GKD S LLKKH LE + +E+ + L+ Q +L+ D+ Q+
Sbjct: 1640 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQIS 1699
Query: 1742 DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDL 1801
++ ++ + +K + RR L + + L+Q R + + E WI EK+++ GS + G+D
Sbjct: 1700 RRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDF 1759
Query: 1802 TGVQNLRKKHKRLEAE--------LAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQF 1853
V L++K +E LAA + +++ G + K+ +
Sbjct: 1760 EHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN------ 1813
Query: 1854 VEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT----LVASEDYGDTLAA 1909
E W EL +L R Q L S E +F ++ E + I EK L + + ++
Sbjct: 1814 -EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 1872
Query: 1910 IQGLLKKHEAFETDFTVHKDRVNDVCTNGQDL--IKKNNHHEENISSKMKGLNGKVSDLE 1967
+Q L+ AFE D + +V + L + H E S + + L G +L
Sbjct: 1873 MQRTLR---AFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW-KELL 1928
Query: 1968 KAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFD 2027
A + + + L+F+ + + SW+ + + D RD+SSV+ L+ +
Sbjct: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
Query: 2028 AGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEA 2087
L+A E + L LL K + I+A+ L RK+++ E
Sbjct: 1989 TELEARVPE-LTTCQELGRSLLLNKSAMADEIQAQ-----------LDKLGTRKEEVSEK 2036
Query: 2088 -QSHFRKVEDLFLT--FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSS 2144
H+ ++ + FA++A ++W E L +S++E++ L H+AFR +
Sbjct: 2037 WDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKA 2096
Query: 2145 LSSAQADFNQLAEL 2158
++ + F+ L L
Sbjct: 2097 AAAWEERFSSLRRL 2110
Score = 348 bits (894), Expect = 3e-95
Identities = 405/1900 (21%), Positives = 791/1900 (41%), Gaps = 134/1900 (7%)
Query: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLR----------RQKLEDSYRFQFFQ 50
+DP V + A D + V+ YH F ++ L Q LE + ++
Sbjct: 258 LDPEDVNM--EAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVGKIIERYE 315
Query: 51 RDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI 110
A EL WI + + S++ + + +L G Q+ QAF A VK E GNL +
Sbjct: 316 ELAAELLAWIHRTVGLISNQKFAN--SLSGVQQQLQAFTAYCTLEKP--VKFQEKGNLEV 371
Query: 111 SEGHFASE--TIRTRLM---------ELHRQWELL--LEKMREKGIK--LLQAQKLVQYL 155
S+ RL ++ + W L E RE ++ L++ +KL
Sbjct: 372 LLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLA 431
Query: 156 RECEDVM----DWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
+ + + W+N+ + +V+ + G +L VE KK E + D+AA+EERV V +
Sbjct: 432 QRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAEL 491
Query: 212 AAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWI 271
A L E + + + ++D V W L GL R+ +L +Q+ +++ + W+
Sbjct: 492 AQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWM 551
Query: 272 KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEA---DRLQQSHPLS 328
+E + + S + G+ L LL+KH LE D+AA ++V+AL A A +LQ P
Sbjct: 552 EEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCD 611
Query: 329 ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINA-- 386
I + + +++ AA R A L S L L + + SW + + L+ A
Sbjct: 612 PQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAG 671
Query: 387 -------------DELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHY 433
A D++ LL +H+ +GE+ + A G+ L+AAG
Sbjct: 672 GGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGA 731
Query: 434 ---ASDEVREKLTVLSEERAALLELWE-------LRRQQYEQCMDLQLFYRDTEQVDNWM 483
+D V L L+E A+ W+ R ++ ++ L F D + + +W+
Sbjct: 732 VGPGADTVH--LVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWL 789
Query: 484 SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
D G S L ++H + A ++ L L +
Sbjct: 790 RDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLV 849
Query: 544 VATRRDALLSRR--NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY 601
VA + + + + + E A RR L D+ + + F + + W+ EK +
Sbjct: 850 VALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRV 909
Query: 602 KDPSNLQGKVQ-KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
D + VQ + ++ + E+++ R+ + Q+L++ H + DEV + + + S W
Sbjct: 910 PDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRW 969
Query: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
+++E E + ++ + V ++ + E + S LQ +
Sbjct: 970 NRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGA-----LQWRL 1024
Query: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
+ LEA + A + R + +A + A + + E L A + AL A + +
Sbjct: 1025 SGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAV 1084
Query: 781 ADSLRLQQLFRDVEDEETW-IREKEPIAASTNRG---KDLIGVQNLLKKHQALQAEIAGH 836
A + RLQ+ D++ W +R +E AA + G L LL +H AL+ E+
Sbjct: 1085 AAAGRLQRFLHDLDAFLDWLVRAQE--AAGGSEGPLPNSLEEADALLARHAALKEEVDQR 1142
Query: 837 EPRIKAVTQKGNAMV-----EEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891
E + A++ E G A D L L W L RR+ L +
Sbjct: 1143 EEDYARIVAASEALLAADGAELGPGLALD--EWLPHLELGWHKLLGLWEARREALVQAHI 1200
Query: 892 AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
Q + D +A +R +E + + +S E LK+H ++ + +Q +
Sbjct: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ 1260
Query: 952 QAQSCRQQVAPTDDETGKELVLALYDYQEKSPR--EVTMKKGDILTLLNSTNKDWWKVEV 1009
A+ +Q ++ + + L QE R + K D L L + +
Sbjct: 1261 AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLR------DC 1314
Query: 1010 NDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQV 1069
++ G++ +K+ A+ +RE+ + L + + +Q + + A + ++++
Sbjct: 1315 HELDGWIH----EKMLMARDGTRED------NHKLHKRWLRHQAFMAELAQNKEW-LEKI 1363
Query: 1070 EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEV 1128
E L++ K L S +K + E++Q W + + + +
Sbjct: 1364 EREGQQLMQ----EKPELAASVRK-----KLGEIRQCWAELESTTQAKARQLFEASKADQ 1414
Query: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
L + F + K L ES+L+D++ DL + +++Q+++ Q E ++T
Sbjct: 1415 LVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQT 1473
Query: 1189 AS-PWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKE 1247
A+ P + A + + ER L + +ER +LL ++ E+ + D D+
Sbjct: 1474 AALPLEPASKEL----VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELA 1529
Query: 1248 WIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESA 1307
W++E+ G+ L +VQ +K++G R++ A G ++ + E A L A
Sbjct: 1530 WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEA 1589
Query: 1308 EDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
E ++ +L AW+ L + A++R+ L + ++++ D ++ +W+ L+ S++
Sbjct: 1590 EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 1649
Query: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQER 1427
KD LL++H + ++ + + + LL GH S +I ++ +D+
Sbjct: 1650 GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLY 1709
Query: 1428 ADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487
L++ +RR+ L+Q L R + E+W+A +E + + G + V L +K
Sbjct: 1710 VALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKF 1769
Query: 1488 EDFDKAINVQ-EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546
+F + E++AA+ D+LI GH A ++ ++ + + W L M +
Sbjct: 1770 SEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL 1829
Query: 1547 LGESQTLQQFSRDVDEIEAWISEK---LQTASDESYKDPTNIQLSKLLSKHQKHQAFEAE 1603
L S+ L +F D E++ I EK L + P+ + + L +AFE +
Sbjct: 1830 LAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL------RAFEHD 1883
Query: 1604 LHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEKSQKLKEA 1662
L ++R + + L R AG +A+ +R + W+ L+ + +
Sbjct: 1884 LQLLVSQVRQLQEGAAQL--RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSST 1941
Query: 1663 NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1722
F++ ++D W+ + + + + D +D++SV L+ HQ L+ ++ A L
Sbjct: 1942 ADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTC 2001
Query: 1723 NSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEE 1782
SL+ + + +++ + D + R +++ L + +HQF ++ +
Sbjct: 2002 QELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVAD 2061
Query: 1783 SWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1822
+W+ ++ L+ S + G + V+ L ++H+ AA E
Sbjct: 2062 AWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWE 2101
Score = 276 bits (706), Expect = 2e-73
Identities = 203/840 (24%), Positives = 389/840 (46%), Gaps = 15/840 (1%)
Query: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY 72
E QE ++L++ + + QKL D Q F RD EL+ WI EK+ +A D
Sbjct: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
+D L + +HQAF AE+ N + K++ G ++ E + ++R +L E+ + W
Sbjct: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393
Query: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFE 192
L + K +L +A K Q ++ ++ + E+ + + G DL V KK +
Sbjct: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 1453
Query: 193 EFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLF 252
++ + V E+ A L E +EL+ +Q+ V RL +R+ L
Sbjct: 1454 SMESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLL 1512
Query: 253 GAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
+ E+ + D+D+ ++W++E+ L + G L +VQ ++K++GL R++ A +++
Sbjct: 1513 ASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLE 1572
Query: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372
+ A L A ++ E+L + W +R A R L+ +++++++ D +
Sbjct: 1573 EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 1632
Query: 373 LTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
+ +W+ E + L+ +++ D LL +H + + ++ +E+S +ALL GH
Sbjct: 1633 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 1692
Query: 433 YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492
S+++ + + + AL EL E RR EQ L R ++++W++++E +
Sbjct: 1693 PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 1752
Query: 493 EDLGDSLDSVEALLKKHEDFEKSLS-AQEEKITALDEFATKLIQNNHYAMEDVATRRDAL 551
+LG + V L +K +F A E++ A+++ +LI+ H A +A +D L
Sbjct: 1753 PELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGL 1812
Query: 552 LSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-----TATDEAYKDPSN 606
L E R LA S L +FF D+ EL+ + EK + T E S+
Sbjct: 1813 NEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 1872
Query: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA---KDEVAARMNEVISLWKKL 663
+Q + +AFE +L S++ L++ +L V YA + +A+R EV+ WK+L
Sbjct: 1873 MQRTL---RAFEHDLQLLVSQVRQLQEGAAQLRTV--YAGEHAEAIASREQEVLQGWKEL 1927
Query: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
L A E + + +F+ V D+ W+ + + + D +D+++V+ L H L
Sbjct: 1928 LSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGL 1987
Query: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
+ ++ A + R A+ I+ + + L R E + E + L
Sbjct: 1988 KTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQM 2047
Query: 784 LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
L + Q ++ + W+ +EP+ S G + V+ L+++H+A + A E R ++
Sbjct: 2048 LEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSL 2107
Score = 268 bits (684), Expect = 6e-71
Identities = 283/1183 (23%), Positives = 497/1183 (42%), Gaps = 66/1183 (5%)
Query: 11 TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDE 70
++++++ + + R++R EL R++++ + + E+ ++EK +
Sbjct: 954 SSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAV--- 1010
Query: 71 NYKDPTNLQGKLQ-KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
+ G LQ + EA +QA L E L+ + + EL
Sbjct: 1011 --ESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGA 1068
Query: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDW-INDKEAIVTSE-ELGQDLEHVEVL 187
+W L + G + A +L ++L + + +DW + +EA SE L LE + L
Sbjct: 1069 EWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADAL 1128
Query: 188 QKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE---LIKTKQDEVNAAWQRLKGLA 244
+ + ++ EE + + L+ E + + W +L GL
Sbjct: 1129 LARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLW 1188
Query: 245 LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDL 304
R+ L A Q F RD+ + + ++ +E ++ + + SV+ L++H +
Sbjct: 1189 EARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTM 1248
Query: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
+ K++ A+ L + + Q Q L+ ++ + A + +L+D LQ
Sbjct: 1249 ELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ 1308
Query: 365 RFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESG 424
FL D +L W+ E K L+ D D RHQ E+ +++ + + G
Sbjct: 1309 HFLRDCHELDGWIHE-KMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREG 1367
Query: 425 QALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
Q L+ + VR+KL + + A L + + +Q + + ++D +
Sbjct: 1368 QQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL 1427
Query: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
E+ L + D G L +V + LKK + E + ++ L + T + + E V
Sbjct: 1428 HMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGEL-QAQTAALPLEPASKELV 1486
Query: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD-EAYKD 603
R++A+ R L E RR L S L Q D D+ +WV E++ A E
Sbjct: 1487 GERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG 1546
Query: 604 PSNLQGKVQKHQAFEAELSANQSRID-ALEKAGQKLIDVNHYAKDEVAARMNEVISLWKK 662
+Q ++K+Q E+ A+ R++ LE+AG L + + V + ++ S W
Sbjct: 1547 LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAVRRGLEQLQSAWAG 1605
Query: 663 LLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHAL 722
L EA E + L A Q +Q+ +V ++E WL E E + S+D GKD + L KKH
Sbjct: 1606 LREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ 1665
Query: 723 LEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
LE V +++ I ++ Q R + GH D+E I ++Q + Y ALKE R+ L
Sbjct: 1666 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 1725
Query: 783 SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAE--IAGHEPRI 840
L QL R V + E WI EKE +A S G+D V L +K +E +AG E R+
Sbjct: 1726 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRE-RL 1784
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
AV Q + ++E GH AA + LN+ W L R Q L S + ++F+DA
Sbjct: 1785 AAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 1844
Query: 901 EAESWMREKEP-IVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-- 957
E + + EK + T + SA ++ + A DL S ++ L+E A R
Sbjct: 1845 ELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTV 1904
Query: 958 ------QQVAPTDDET---GKELVLALYDYQ------------EKSPREVTMKKGDILTL 996
+ +A + E KEL+ A D + R++ I +
Sbjct: 1905 YAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQ 1964
Query: 997 LNSTNK--DWWKVEV--NDRQGFVPA--AYVKKLDPAQSASRENLLEEQGSIALRQEQID 1050
+ + +K D VEV N QG A V +L Q R LL + Q Q+D
Sbjct: 1965 IGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLD 2024
Query: 1051 NQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEK 1110
+ R ++V E + ++ L++ + +EA W+ +
Sbjct: 2025 K----------LGTRKEEVSEKW-------DRHWEWLQQMLEVHQFAQEAVVADAWLTAQ 2067
Query: 1111 EAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKV 1153
E L S E+G+ +++VE L ++ + F+K A E R + ++
Sbjct: 2068 EPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRL 2110
Score = 223 bits (569), Expect = 1e-57
Identities = 149/527 (28%), Positives = 262/527 (49%), Gaps = 10/527 (1%)
Query: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDE 70
AE ++ +Q+ + +E + R+Q L+ +++ + + D E+E W+ +++L + S++
Sbjct: 1589 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 1648
Query: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
KD + L+KH E V+ +I +L ++ GH SE I R ++ R
Sbjct: 1649 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
Query: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
+ L E E+ + L Q L Q R+ ++ WI +KE + S ELGQD EHV VLQ+K
Sbjct: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
Query: 191 FEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
F EF ++ A ER+ VNQ +LI+ H + +D +N AW L L R
Sbjct: 1769 FSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQ 1828
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQ----LMASDDFGRDLASVQALLRKHEGLERDLA 305
L + E+ +F D E I+EK + L + +S+Q LR E DL
Sbjct: 1829 LLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQ 1885
Query: 306 ALEDKVKALCAEADRLQQSHPLS-ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
L +V+ L A +L+ + A I + +E++ W+++ + + ++ +
Sbjct: 1886 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 1945
Query: 365 RFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESG 424
RF + RDL SW+ + + I A + DV+ E L++ HQ K E++A + E G
Sbjct: 1946 RFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELG 2005
Query: 425 QALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
++LL +DE++ +L L + + E W+ + +Q +++ F ++ D W++
Sbjct: 2006 RSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLT 2065
Query: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
QE L + +LG S+D VE L+++HE F K+ +A EE+ ++L T
Sbjct: 2066 AQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT 2112
Score = 41.6 bits (96), Expect = 0.010
Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 9/142 (6%)
Query: 2180 LEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCM 2239
+++ W L+K ERE L+ E RQE+ + L Q F W+ E + +
Sbjct: 399 IDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQ---- 454
Query: 2240 VEESGTLESQLEATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGL 2295
+ G +EA +KH+ +I A +++ + +L A+ D + +
Sbjct: 455 -DNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSV 513
Query: 2296 AQQWDQLDQLGMRMQHNLEQQI 2317
+QW L L + LEQ +
Sbjct: 514 LRQWALLTGLVGARRTRLEQNL 535
Score = 35.8 bits (81), Expect = 0.54
Identities = 62/333 (18%), Positives = 126/333 (37%), Gaps = 27/333 (8%)
Query: 1954 SKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDL 2013
SKMK L + + K Q L+ ++ A + +WI + + L
Sbjct: 285 SKMKALAVEGKRIGKVLDQ---VLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSL 341
Query: 2014 SSVQTLL---TKQETFDAGLQAFQQEGIANIT--ALKDQLLAAKHVQSKAIEARHA-SLM 2067
S VQ L T T + ++ FQ++G + +++ +L A E +
Sbjct: 342 SGVQQQLQAFTAYCTLEKPVK-FQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDID 400
Query: 2068 KRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNS 2127
K W +L R+ L K+E L F K + SW + ++
Sbjct: 401 KAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYE 460
Query: 2128 LEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL 2187
L ++A + H+A + +++ + +AEL + + + +++ W L
Sbjct: 461 LPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALL 520
Query: 2188 QKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSC--------- 2238
++ R + R E+N L++ F Q W++E + LL C
Sbjct: 521 TGLVGAR-------RTRLEQNLALQKVF-QEMVYMVDWMEEMQAQLLSRECGQHLVEADD 572
Query: 2239 MVEESGTLESQLEATKRKHQEIRAMRSQLKKIE 2271
++++ G LE + A + + + A + +++
Sbjct: 573 LLQKHGLLEGDIAAQSERVEALNAAALRFSQLQ 605
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 290 bits (741), Expect = 2e-77
Identities = 166/499 (33%), Positives = 275/499 (55%), Gaps = 17/499 (3%)
Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
+F KA + E+W KE LK DY LS ++ L+ K E F++ L A Q+ + I A
Sbjct: 417 KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAA-HQDRVEQIAA 475
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
+ +L + S + R + +W L + + +R++ L + + ++ L L +AK
Sbjct: 476 IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535
Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIK 2163
+A+ FN+W E+A EDL D +++EEI+ L AHD F+S+L A + + + ++ +
Sbjct: 536 RAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQ 595
Query: 2164 SFRVA-------SNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2216
+ SNPYT T + + W +Q+++ +R+ L +EQ +Q+ N+ LR++FA
Sbjct: 596 RIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFA 655
Query: 2217 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2276
AN WIQ + G +E +GTLE QL K+ + I + L +E
Sbjct: 656 SQANVVGPWIQTKMEEI--GRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQL 713
Query: 2277 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2336
++EALI DNK+T ++ + W+QL R + +E QI R+ G+++E ++EF
Sbjct: 714 IQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRAS 773
Query: 2337 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2396
F HFDKD G L +EFK+CL SLGYD+ +GE EF I+ VDPN G V+ Q +
Sbjct: 774 FNHFDKDHGGALGPEEFKACLISLGYDVENDRQGE--AEFNRIMSLVDPNHSGLVTFQAF 831
Query: 2397 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2456
+ FM SRET + +++++ ++F+ L+ + K ++T EEL + L +QA+YC++ M PY
Sbjct: 832 IDFM-SRETTDTDTADQVIASFKVLAGD-KNFITAEELRRELPPDQAEYCIARMAPYQGP 889
Query: 2457 KGRELPTAFDYVEFTRSLF 2475
+P A DY F+ +L+
Sbjct: 890 DA--VPGALDYKSFSTALY 906
Score = 85.5 bits (210), Expect = 6e-16
Identities = 121/611 (19%), Positives = 242/611 (39%), Gaps = 107/611 (17%)
Query: 1693 KDLASVNNLLKKH--QLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGR 1750
KD + N L+ +H +L+E D +D + +LN+ + + D ++ D D +N
Sbjct: 193 KDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFE--VAEKYLDIPKMLDAEDIVNTA 250
Query: 1751 FQKIKSM-------------------AASRRAKL-----NESHRLHQFFRDMDDEESWIK 1786
K++ AA+R K+ H + + + D WI+
Sbjct: 251 RPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIR 310
Query: 1787 E--------------KKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL----------AAHE 1822
+++ ED+ RD V K ++ + E+ ++
Sbjct: 311 RTIPWLEDRVPQKTIQEMQQKLEDF-RDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNR 369
Query: 1823 PAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHW--KELKQLAAARGQRLEESLEYQQF 1880
PA GK +SD N G + ++Q + E W E+++L +RL+ E +F
Sbjct: 370 PAFMP--SEGKMVSDINN-GWQHLEQAEKGY-EEWLLNEIRRL-----ERLDHLAE--KF 418
Query: 1881 VANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQ 1939
EAW + K ++ DY TL+ I+ L++KHEAFE+D H+DRV + Q
Sbjct: 419 RQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQ 478
Query: 1940 DLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE--------NSAFLQFNWKAD 1991
+L + + + N++++ + + + L R+ L++ + L++ +A
Sbjct: 479 ELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAA 538
Query: 1992 VVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2051
+W+ L+ + ++ L++ + F + L +E ++ +LA
Sbjct: 539 PFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADRE--------REAILAI 590
Query: 2052 KHVQSKAIEARHASLM--------------KRWSQLLANSAARKKKLLEAQSHFRKVEDL 2097
+ E+ H L +W ++ R LLE QS + E L
Sbjct: 591 HKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHL 650
Query: 2098 FLTFAKKASAFNSWFENAEEDL-TDPVRCNSL--EEIKALREAHDAFRSSLSSAQADFNQ 2154
FA +A+ W + E++ + N +++ L++ + S+ + + +
Sbjct: 651 RRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ----YERSIVDYKPNLDL 706
Query: 2155 LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEE---NDKL 2211
L + + I+ + N +T +TME + W L I E++ + ++ + +
Sbjct: 707 LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQ 766
Query: 2212 RQEFAQHANAF 2222
QEF N F
Sbjct: 767 MQEFRASFNHF 777
Score = 68.2 bits (165), Expect = 1e-10
Identities = 104/487 (21%), Positives = 206/487 (42%), Gaps = 76/487 (15%)
Query: 154 YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE----- 207
Y + D+++WI + I E+ + ++ +Q+K E+F+ H+ +V E
Sbjct: 298 YEKLASDLLEWI--RRTIPWLEDRVPQ-KTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLE 354
Query: 208 --VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRL----KGLA------LQRQGKLFGA 254
N KL P + K ++N WQ L KG ++R +L
Sbjct: 355 INFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHL 414
Query: 255 AEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALEDKVKA 313
AE R + E +W KE ++ D+ L+ ++AL+RKHE E DLAA +D+V+
Sbjct: 415 AEKFRQKASIHE--AWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQ 472
Query: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR----------- 362
+ A A L + + + + +++ W+ + +L R L + +
Sbjct: 473 IAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLE 532
Query: 363 -----------LQRFLADFRD--LTSWVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408
++ + D +D + + E++ LI+A D+ S L D +E +
Sbjct: 533 YAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKS------TLPDADREREA 586
Query: 409 EIDAHEDSFKSADESGQALLAAGHYAS------DEVREKLTVLSEER-AALLELWELRRQ 461
+ H+++ + A+ + L + Y + + EK+ L +R ALLE E +Q
Sbjct: 587 ILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE--EQSKQ 644
Query: 462 QYEQCMDLQLFYRDTEQVDNWM--SKQEAFLLNEDLGDSLDSVEALLKKHE----DFEKS 515
Q + + Q F V W+ +E ++ ++ +L+ + LK++E D++ +
Sbjct: 645 QSNEHLRRQ-FASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPN 703
Query: 516 LSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLS----RRNALHERAMRRRAQLAD 571
L E++ + E ++ +Y ME + + LL+ N + + + R A+
Sbjct: 704 LDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGIS 763
Query: 572 SFHLQQF 578
+Q+F
Sbjct: 764 QEQMQEF 770
Score = 60.1 bits (144), Expect = 3e-08
Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 9/137 (6%)
Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
+ ++N W+ L+Q L E +L H ++F + A + W + K L
Sbjct: 380 VSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHR 439
Query: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
+Y L+ ++AL RKHE FE DLAA D+V + A+ L + + ++ +C ++
Sbjct: 440 DYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKIC 499
Query: 1319 QAWSSLGKRADQRKAKL 1335
W +LG R+ L
Sbjct: 500 DQWDALGSLTHSRREAL 516
Score = 59.3 bits (142), Expect = 5e-08
Identities = 72/340 (21%), Positives = 137/340 (40%), Gaps = 38/340 (11%)
Query: 1645 WQFLVQKSAEKSQK---LKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK- 1693
WQ L Q AEK + L E + + + + F + W EA+L DY
Sbjct: 387 WQHLEQ--AEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETA 444
Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
L+ + L++KH+ E+D++AH+DR++ + + A L +D+ V + I ++
Sbjct: 445 TLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDA 504
Query: 1754 IKSMAASRRAKLNESHR-------LH-QFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ 1805
+ S+ SRR L ++ + LH ++ + +W++ + + ++
Sbjct: 505 LGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIE 564
Query: 1806 NLRKKHKRLEAELA---AHEPAIQGVLDTGKKLSDDNTI---GKEEIQQRLAQFV-EHWK 1858
L H + ++ L AI + +++++ N I G Q + W+
Sbjct: 565 GLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWE 624
Query: 1859 ELKQLAAARGQRLEESLEYQ--------QFVANVEEEEAWINEKMTLVA--SEDYGDTLA 1908
+++QL R L E Q QF + WI KM + S + TL
Sbjct: 625 KVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLE 684
Query: 1909 AIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHH 1948
LK++E D+ + D + Q+ + +N H
Sbjct: 685 DQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKH 724
Score = 58.5 bits (140), Expect = 8e-08
Identities = 62/301 (20%), Positives = 122/301 (40%), Gaps = 31/301 (10%)
Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
++F + E W E L DY L++++ L +KH E+D+AAHQDR++ I
Sbjct: 416 EKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAA 475
Query: 740 QARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL---------ADSLRLQQLF 790
A++ + ++D+ N+ + + + +++AL +R++ L D L L+
Sbjct: 476 IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535
Query: 791 RDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG---HEPRIKAVTQKG 847
R W+ + ++ L+ H ++ + I A+ ++
Sbjct: 536 R-AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEA 594
Query: 848 NAMVEEGHFAAED----VKAKLHELNQKWEALKAKASQRRQDL--EDSLQ------AQQY 895
+ E H +N KWE ++ +R L E S Q +Q+
Sbjct: 595 QRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQF 654
Query: 896 FADANEAESWMREKEPIVG--STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQA 953
+ AN W++ K +G S + + + LK++E + D Y ++ L +Q
Sbjct: 655 ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVD---YKPNLDLLEQQH 711
Query: 954 Q 954
Q
Sbjct: 712 Q 712
Score = 56.2 bits (134), Expect = 4e-07
Identities = 48/250 (19%), Positives = 105/250 (42%), Gaps = 14/250 (5%)
Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
++R LD E F + E W +EA L D + +L ++ALI+KHE F+
Sbjct: 405 IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL------KAQMIEKRSKL 1547
+ ++++ + A A +L +Y ++++R ++ D+W L + + +EK K
Sbjct: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQ 522
Query: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
E+ Q ++++ W+ ++ D + T ++ L+S H + ++ +
Sbjct: 523 LEAIDQLHLEYAKRAAPFNNWMESAMEDLQD-MFIVHTIEEIEGLISAHDQFKSTLPDAD 581
Query: 1606 ANADRIRGVIDMGNSLIERG--ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
+ I + + E +GS + +W+ + Q ++ L E
Sbjct: 582 REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641
Query: 1664 KQQNFNTGIK 1673
+Q N ++
Sbjct: 642 SKQQSNEHLR 651
Score = 55.8 bits (133), Expect = 5e-07
Identities = 74/408 (18%), Positives = 157/408 (38%), Gaps = 47/408 (11%)
Query: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
PS K++ + + +Q Y + L+ +RR + D +F Q+ A E W
Sbjct: 374 PSEGKMVSDINNGWQHLEQAEKGYEEWL-LNEIRRLERLDHLAEKFRQK-ASIHEAWTDG 431
Query: 63 KLQIASDENYKDPT--NLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
K + +Y+ T +++ ++KH+AFE+++ A+ + ++ + ++ S +
Sbjct: 432 KEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNV 491
Query: 121 RTRLMELHRQWELL------LEKMREKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172
TR ++ QW+ L + EK K L+A Q ++Y + +W+ +
Sbjct: 492 NTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDL 551
Query: 173 TSEELGQDLEHVEVLQKKFEEFQT---DMAAHEERVNEVNQFAAKLIQEQH----PEEEL 225
+ +E +E L ++F++ D E + +++ A ++ + H
Sbjct: 552 QDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPY 611
Query: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277
+N+ W++++ L +R L Q+ N + + WI+ K
Sbjct: 612 TTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTK--- 668
Query: 278 MASDDFGRDLASVQALLRKH----EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQ 333
++ GR + L + ER + + + L + +Q++
Sbjct: 669 --MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTN 726
Query: 334 VKREELITNWEQIRTLAAE-----------RHARLNDSYRLQRFLADF 370
E + WEQ+ T A R A+ ++Q F A F
Sbjct: 727 YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASF 774
Score = 52.4 bits (124), Expect = 6e-06
Identities = 75/369 (20%), Positives = 149/369 (40%), Gaps = 63/369 (17%)
Query: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621
RR + D HL + FR + ++W + K Y+ S+++ ++KH+AFE++L
Sbjct: 406 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDL 463
Query: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW----------KKLLEATE--- 668
+A+Q R++ + Q+L ++++Y V R ++ W ++ LE TE
Sbjct: 464 AAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL 523
Query: 669 --LKGIKLREANQQQQFNRNVED---------IELWLYEVEGHLASDDYGKDLTNVQNLQ 717
+ + L A + FN +E I + E+EG +++ D Q
Sbjct: 524 EAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHD-----------Q 572
Query: 718 KKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENI---------------KKKQEAL 762
K L +AD ++ I I +A++ ++ H +K Q+ +
Sbjct: 573 FKSTLPDAD--REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLV 630
Query: 763 VARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK-EPIAASTNRGKDLIGVQN 821
R AL E KQ+ + LR +Q WI+ K E I + + ++
Sbjct: 631 PKRDHALLEEQ--SKQQSNEHLR-RQFASQANVVGPWIQTKMEEIGRISIEMNGTL--ED 685
Query: 822 LLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQ 881
L + + I ++P + + Q+ + E F + + + WE L ++
Sbjct: 686 QLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIAR 745
Query: 882 RRQDLEDSL 890
++E+ +
Sbjct: 746 TINEVENQI 754
Score = 36.2 bits (82), Expect = 0.41
Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDS-AEALLKKHEALMSDLS 940
RR + D L A+++ A+ E+W KE ++ DY S +AL++KHEA SDL+
Sbjct: 406 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLA 464
Query: 941 AYGSSIQALREQAQSCRQ 958
A+ ++ + AQ +
Sbjct: 465 AHQDRVEQIAAIAQELNE 482
Score = 34.7 bits (78), Expect = 1.2
Identities = 50/256 (19%), Positives = 101/256 (39%), Gaps = 52/256 (20%)
Query: 1019 AYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSL 1076
A ++K + +S A+ ++ +E+ +IA ++D ++ +V+ R +++ + + +L
Sbjct: 451 ALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYY-----DSHNVNTRCQKICDQWDAL 505
Query: 1077 LELGEKRKGMLEKSCKKFMLF--------REANELQQWINEKEAALTSEEVGADLEQVEV 1128
L R+ LEK+ K+ + A W+ L + +E++E
Sbjct: 506 GSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEG 565
Query: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
L D F+ S L D D E E ++A +A + E + T
Sbjct: 566 LISAHDQFK-------STLPDA-----DREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613
Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLA--------EERSQLLGSAHEVQRFHR 1240
+P + +N +W +QQL EE+S+ + H ++F
Sbjct: 614 VTP-----------------QIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFAS 656
Query: 1241 DADETKEWIEEKNQAL 1256
A+ WI+ K + +
Sbjct: 657 QANVVGPWIQTKMEEI 672
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 288 bits (738), Expect = 4e-77
Identities = 167/501 (33%), Positives = 282/501 (56%), Gaps = 21/501 (4%)
Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
+F KA + E+W KE L+ DY LS ++ LL K E F++ L A Q+ + I A
Sbjct: 398 KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRVEQIAA 456
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
+ +L + S ++ AR + +W L A + R++ L + ++ L+L +AK
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA------E 2157
+A+ FN+W E A EDL D +++EEI+ L AH+ F+++L A D +LA E
Sbjct: 517 RAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA--DKERLAILGIHNE 574
Query: 2158 LDRQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQE 2214
+ + ++++ V +NPYT T + + W ++++++ R+ L +E RQ+ N++LR++
Sbjct: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
Query: 2215 FAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
F AN WIQ + G +E GTLE QL ++ + I + ++ ++E
Sbjct: 635 FGAQANVIGPWIQTKMEEI--GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
Query: 2275 AAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFS 2334
++EALI DNK+T ++ + W+QL R + +E QI R+ G+++E + EF
Sbjct: 693 QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR 752
Query: 2335 MMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQ 2394
F HFD+D SG L +EFK+CL SLGYD+ +GE EF I+ VDPNR G V+ Q
Sbjct: 753 ASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGE--AEFARIMSIVDPNRLGVVTFQ 810
Query: 2395 EYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYV 2454
++ FM SRET + +++++ ++F+ L+ + K Y+T +EL + L +QA+YC++ M PY
Sbjct: 811 AFIDFM-SRETADTDTADQVMASFKILAGD-KNYITMDELRRELPPDQAEYCIARMAPYT 868
Query: 2455 DGKGRELPTAFDYVEFTRSLF 2475
+P A DY+ F+ +L+
Sbjct: 869 GPD--SVPGALDYMSFSTALY 887
Score = 83.6 bits (205), Expect = 2e-15
Identities = 83/382 (21%), Positives = 162/382 (42%), Gaps = 47/382 (12%)
Query: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFT 1925
R +RL+ E +F EAW + K ++ +DY TL+ I+ LLKKHEAFE+D
Sbjct: 388 RLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE 1979
H+DRV + Q+L + + + +++++ + + G ++ + A +R KL E
Sbjct: 446 AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505
Query: 1980 --NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
+ +L++ +A +W+ L+ + +Q L T E F A L +E
Sbjct: 506 TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565
Query: 2038 IANITALKDQLLAAKHVQSKAIEARHASLM--------------KRWSQLLANSAARKKK 2083
+A +L + SK ++ H ++ +W + R +
Sbjct: 566 LA--------ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA 617
Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDA 2140
L E + + E L F +A+ W + E+ ++ + +++ LR+
Sbjct: 618 LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ---- 673
Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL----QKIIKEREL 2196
+ S+ + + +QL + I+ + N +T +TME + W L + I E E
Sbjct: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733
Query: 2197 ELQKEQRR---QEENDKLRQEF 2215
++ + QE+ ++ R F
Sbjct: 734 QILTRDAKGISQEQMNEFRASF 755
Score = 60.1 bits (144), Expect = 3e-08
Identities = 50/250 (20%), Positives = 110/250 (44%), Gaps = 14/250 (5%)
Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
++R LD E F + E W +EA L +D + +L ++AL+KKHE F+
Sbjct: 386 IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKA------QMIEKRSKL 1547
+ ++++ + A A +L +Y +++R ++ D+W L A + +E+ KL
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
E+ Q ++++ W+ ++ D ++ T ++ L + H++ +A +
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQD-TFIVHTIEEIQGLTTAHEQFKATLPDAD 562
Query: 1606 ANADRIRGVIDMGNSLIE--RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
I G+ + + +++ AG+ + +W + Q + Q L E +
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
Query: 1664 KQQNFNTGIK 1673
+Q N ++
Sbjct: 623 ARQQHNERLR 632
Score = 58.9 bits (141), Expect = 6e-08
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 9/137 (6%)
Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
+ ++N W L+Q L E +L H ++F + A + W + K L
Sbjct: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
Query: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
+Y L+ ++AL +KHE FE DLAA D+V + A+ L + + + +C ++
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
Query: 1319 QAWSSLGKRADQRKAKL 1335
W +LG +R+ L
Sbjct: 481 DQWDNLGALTQKRREAL 497
Score = 58.9 bits (141), Expect = 6e-08
Identities = 72/348 (20%), Positives = 142/348 (40%), Gaps = 49/348 (14%)
Query: 357 LNDSYRLQRF--LAD-FRDLTS----WVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408
LN+ RL+R LA+ FR S W +A++ D + ++ +ALL +H+ +
Sbjct: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFES 442
Query: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468
++ AH+D + Q L +Y S V + + ++ L L + RR+ E+
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
Query: 469 L-----QLFYRDTEQV---DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQ 519
L QL+ ++ +NWM L + + +++ ++ L HE F+ +L A
Sbjct: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
Query: 520 EEK--ITALDEFATKLIQNNHYAM---------------------EDVATRRDALLSRRN 556
+E+ I + +K++Q H M + RRD L+ +
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
Query: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
A + R R +QF ++ + W+ KM+ + + L+ ++ +
Sbjct: 623 ARQQHNERLR---------KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ 673
Query: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
+E + + +ID LE Q + + + M + W++LL
Sbjct: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
Score = 57.4 bits (137), Expect = 2e-07
Identities = 84/389 (21%), Positives = 154/389 (39%), Gaps = 44/389 (11%)
Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
Q++E KL S L+ R + +E + E A + +D + + L K K Q
Sbjct: 274 QLMEDYEKLA-SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY---RRLHKPPKVQ 329
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657
+ +L N + ++ + + N R A SE + ++ + + W L Q + +
Sbjct: 330 E-KCQLEINFNTLQTKLRLSN----RPAFMPSEGRM---VSDINNAWGCLEQVEKGYEEW 381
Query: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLE 1709
L E + + + + F + W EA+L +DY L+ + LLKKH+ E
Sbjct: 382 LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
Query: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769
+D++AH+DR++ + + A L +D+ V + I ++ + ++ RR L +
Sbjct: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
Query: 1770 RLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821
+L + + E +W++ + + +Q L H++ +A L
Sbjct: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
Query: 1822 EP---AIQGVLDTGKKLSDD---NTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEES 1874
+ AI G+ + K+ N G Q + W ++QL R Q L E
Sbjct: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
Query: 1875 LEYQ--------QFVANVEEEEAWINEKM 1895
Q QF A WI KM
Sbjct: 622 HARQQHNERLRKQFGAQANVIGPWIQTKM 650
Score = 57.0 bits (136), Expect = 2e-07
Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 25/235 (10%)
Query: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE 207
Q + Y + D+++WI + + ++ H +Q+K E+F+ H+ +V E
Sbjct: 274 QLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHA--MQQKLEDFRDYRRLHKPPKVQE 330
Query: 208 -------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRLKGLA----------LQRQG 249
N KL P + + ++N AW L+ + ++R
Sbjct: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALE 308
+L AE R + E +W KE ++ D+ L+ ++ALL+KHE E DLAA +
Sbjct: 391 RLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
Query: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
D+V+ + A A L + + + + +++ W+ + L +R L + +L
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/347 (19%), Positives = 143/347 (41%), Gaps = 31/347 (8%)
Query: 32 LSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPT--NLQGKLQKHQAFE 89
L+ +RR + D +F Q+ A E W K + ++Y+ T ++ L+KH+AFE
Sbjct: 383 LNEIRRLERLDHLAEKFRQK-ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
Query: 90 AEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE---LLLEKMR---EKGI 143
+++ A+ + ++ + ++ S ++ R ++ QW+ L +K R E+
Sbjct: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
Query: 144 KLLQA--QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMA-A 200
KLL+ Q ++Y + +W+ + + +E ++ L E+F+ + A
Sbjct: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
Query: 201 HEER--VNEVNQFAAKLIQEQHPE----EELIKTKQDEVNAAWQRLKGLALQRQGKLFGA 254
+ER + ++ +K++Q H E+N W ++ L +R L
Sbjct: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
Query: 255 AEVQRFNRDVDETIS--------WIKEKEQLMA--SDDFGRDLASVQALLRKHEGLERDL 304
Q+ N + + WI+ K + + S + L + LR++ E+ +
Sbjct: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQY---EKSI 678
Query: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
+ K+ L + +Q++ E + WEQ+ T A
Sbjct: 679 VNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
Score = 57.0 bits (136), Expect = 2e-07
Identities = 57/286 (19%), Positives = 118/286 (41%), Gaps = 31/286 (10%)
Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
++F + E W E L DY L+ ++ L KKH E+D+AAHQDR++ I
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQLFRDV 793
A++ + ++D+ ++ + + + +++ L + + R +KL ++ + QL+ +
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET--IDQLYLEY 514
Query: 794 EDE----ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR---IKAVTQK 846
W+ T + +Q L H+ +A + + I + +
Sbjct: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE 574
Query: 847 GNAMVEEGHFAAEDVKAKL----HELNQKWEALKAKASQRRQDLEDSLQAQ--------Q 894
+ +V+ H E+N KW+ ++ +R Q L + Q Q
Sbjct: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
Query: 895 YFADANEAESWMREKEPIVGSTD---YGKDEDSAEALLKKHEALMS 937
+ A AN W++ K +G +G ED L + +++++
Sbjct: 635 FGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVN 680
Score = 54.3 bits (129), Expect = 1e-06
Identities = 65/317 (20%), Positives = 127/317 (40%), Gaps = 34/317 (10%)
Query: 482 WMSKQEAFLLNEDLGDS-LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
W +EA L +D + L ++ALLKKHE FE L+A ++++ + A +L + ++Y
Sbjct: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWVNE 591
V R + + + L +RR L D +L ++ + + +W+
Sbjct: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYL-EYAKRAAPFNNWMEG 527
Query: 592 KMKTATDE-AYKDPSNLQGKVQKHQAFEAEL-SANQSRIDAL--EKAGQKLIDVNHY--- 644
M+ D +QG H+ F+A L A++ R+ L K++ H
Sbjct: 528 AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA 587
Query: 645 -AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVED--------IELWL- 694
E+ W + + + L E + +QQ N + I W+
Sbjct: 588 GTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQ 647
Query: 695 --YEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDA 752
E G ++ + +G + +L++ E + ++ +ID + + Q+A FD
Sbjct: 648 TKMEEIGRISIEMHGTLEDQLSHLRQ----YEKSIVNYKPKIDQLEGDHQLIQEALIFDN 703
Query: 753 ENIKKKQEALVARYEAL 769
++ E + +E L
Sbjct: 704 KHTNYTMEHIRVGWEQL 720
Score = 51.6 bits (122), Expect = 9e-06
Identities = 65/326 (19%), Positives = 136/326 (41%), Gaps = 54/326 (16%)
Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093
N L+ + ++ R + ++ R+ + + ++QVE+ Y L +R L+ +K
Sbjct: 339 NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
Query: 1094 FMLFREANELQQWINEKEAALTSEEVG-ADLEQVEVLQKKFDDFQKDLKANESRLKDINK 1152
F ++A+ + W + KEA L ++ A L +++ L KK + F+ DL A++ R++ I
Sbjct: 399 FR--QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 1153 VAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELN 1212
+A++L + + Y SP +AR +++
Sbjct: 457 IAQELN-------------ELDYYD------------SPSVNARC-----------QKIC 480
Query: 1213 ERWRSLQQLAEERSQLLGSAHEVQR--------FHRDADETKEWIEEKNQALNTDNYGHD 1264
++W +L L ++R + L ++ + + A W+E + L H
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
Query: 1265 LASVQALQRKHEGFERDLA-ALGDKVNSLG--ETAERLIQSHPESAEDLQEKCT----EL 1317
+ +Q L HE F+ L A +++ LG +++Q++ + T E+
Sbjct: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
Query: 1318 NQAWSSLGKRADQRKAKLGDSHDLQR 1343
N W + + +R L + H Q+
Sbjct: 601 NGKWDHVRQLVPRRDQALTEEHARQQ 626
Score = 51.6 bits (122), Expect = 9e-06
Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 9/121 (7%)
Query: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621
RR + D HL + FR + ++W + K + Y+ S ++ ++KH+AFE++L
Sbjct: 387 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
Query: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
+A+Q R++ + Q+L ++++Y V AR ++ W L T+ K REA ++
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ----KRREALERT 500
Query: 682 Q 682
+
Sbjct: 501 E 501
Score = 48.5 bits (114), Expect = 8e-05
Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 8/114 (7%)
Query: 776 RKQKLADSLRLQQLFRDV--EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEI 833
R LA+ R + + + +E +R+K+ A+ + ++ LLKKH+A ++++
Sbjct: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE------IKALLKKHEAFESDL 444
Query: 834 AGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
A H+ R++ + + E ++ + V A+ ++ +W+ L A +RR+ LE
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
Score = 40.4 bits (93), Expect = 0.022
Identities = 55/290 (18%), Positives = 115/290 (39%), Gaps = 32/290 (11%)
Query: 1315 TELNQAWSSLGK-RADQRKAKLGDSHDLQRF---LSDFRDLMS----WINGIRGLV-SSD 1365
+++N AW L + + L + L+R FR S W +G ++ D
Sbjct: 362 SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKD 421
Query: 1366 ELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQ 1425
++ +ALL++H+ +++ A + Q+L +Y SP + + +
Sbjct: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
Query: 1426 ERADLEKAWVQRRMMLDQCLEL-----QLFHRDCEQA---ENWMAAREAFLNTEDKGDSL 1477
+ +L +RR L++ +L QL+ ++A NWM L ++
Sbjct: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
Query: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAAL----------QAFADQLIAAGHY---AKGDIS 1523
+ ++ L HE F + + +E++A L Q + + Y +I+
Sbjct: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
Query: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQ 1572
+ + V R + E+ ++ ++ L +QF + I WI K++
Sbjct: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKME 651
Score = 38.5 bits (88), Expect = 0.083
Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA-EALLKKHEALMSDLS 940
RR + D L A+++ A+ E+W KE ++ DY S +ALLKKHEA SDL+
Sbjct: 387 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
Query: 941 AYGSSIQALREQAQSCRQ 958
A+ ++ + AQ +
Sbjct: 446 AHQDRVEQIAAIAQELNE 463
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 280 bits (717), Expect = 1e-74
Identities = 165/499 (33%), Positives = 275/499 (55%), Gaps = 22/499 (4%)
Query: 1985 QFNWKADVVESWIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
+F KA E+W KE L DY L+ V+ LL K E F++ L A Q+ + I A
Sbjct: 405 KFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA-HQDRVEQIAA 463
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
+ +L + + + R + +W +L + R++ L + ++ L L FAK
Sbjct: 464 IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523
Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA----ELD 2159
+A+ FN+W E A EDL D +S+EEI++L AH+ F+++L A + + E++
Sbjct: 524 RAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVE 583
Query: 2160 RQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2216
+ I+S+ + +SNPY+ TM+ L W +++++ R+ LQ+E RQ N++LR++FA
Sbjct: 584 KVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFA 643
Query: 2217 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2276
ANA WIQ + S + +G LE Q+ K+ I ++ + K+E
Sbjct: 644 AQANAIGPWIQNKMEEIARSSIQI--TGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQL 701
Query: 2277 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2336
++EAL+ DNK+T ++ + W+ L R + +E QI R+ G+T+E + EF
Sbjct: 702 IQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRAS 761
Query: 2337 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2396
F HFD+ K+G ++H++F++CL S+GYDL + EF I+ VDPN G V+ Q +
Sbjct: 762 FNHFDRRKNGLMDHEDFRACLISMGYDL-------GEAEFARIMTLVDPNGQGTVTFQSF 814
Query: 2397 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2456
+ FM +RET + ++E++ ++FR L+S+ KPY+ EEL + L +QA YC+ M Y G
Sbjct: 815 IDFM-TRETADTDTAEQVIASFRILASD-KPYILAEELRRELPPDQAQYCIKRMPAY-SG 871
Query: 2457 KGRELPTAFDYVEFTRSLF 2475
G +P A DY F+ +L+
Sbjct: 872 PG-SVPGALDYAAFSSALY 889
Score = 90.9 bits (224), Expect = 1e-17
Identities = 108/512 (21%), Positives = 213/512 (41%), Gaps = 47/512 (9%)
Query: 1742 DKRDTINGRFQKIKSMAASRRAKLNESHRL-HQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800
++ +T R K+ ++ + E RL + + W++ + + +
Sbjct: 260 EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319
Query: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ---------QRLA 1851
L ++ R+KHK + + L T ++S+ E + QRL
Sbjct: 320 LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379
Query: 1852 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAI 1910
Q + ++E R +RLE E +F E W K ++ +DY +L +
Sbjct: 380 QAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWAYGKEQILLQKDYESASLTEV 437
Query: 1911 QGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVS 1964
+ LL+KHEAFE+D H+DRV + Q+L + + H N++ + + + G ++
Sbjct: 438 RALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLT 497
Query: 1965 DLEKAAAQRKAKLDE--NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTK 2022
+ A +R KL E + L+F +A +W+ L+ + +Q+L+T
Sbjct: 498 QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITA 557
Query: 2023 QETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHAS---------LMKRWSQL 2073
E F A L E +I A+++++ K +QS I ++ L +W ++
Sbjct: 558 HEQFKATLPEADGER-QSIMAIQNEV--EKVIQSYNIRISSSNPYSTVTMDELRTKWDKV 614
Query: 2074 LANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2133
R + L E + E L FA +A+A W +N E++ +S++ A
Sbjct: 615 KQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIAR----SSIQITGA 670
Query: 2134 LREAHD---AFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR----N 2186
L + + + ++ + + + ++L + I+ V N +T +TME + W
Sbjct: 671 LEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTT 730
Query: 2187 LQKIIKERELELQKEQRR---QEENDKLRQEF 2215
+ + I E E ++ + QE+ ++ R F
Sbjct: 731 IARTINEVETQILTRDAKGITQEQMNEFRASF 762
Score = 72.8 bits (177), Expect = 4e-12
Identities = 94/445 (21%), Positives = 174/445 (39%), Gaps = 46/445 (10%)
Query: 505 LLKKHEDFEKSLSAQEEKITAL-DEFATKLIQNNHY------AMEDVATRRDALLSRRNA 557
+ +KH D K L A++ T DE A + Y + A R + N
Sbjct: 218 IAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQ 277
Query: 558 LHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAF 617
+ER M +LA L+ R L++ EK A + +D + + K + +
Sbjct: 278 ENERLMEEYERLASEL-LEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQ 336
Query: 618 E-AELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE------LK 670
E +L N + + + + + K ++++ W++L +A + L
Sbjct: 337 EKCQLEINFNTLQTKLRISNRPAFMPSEGK-----MVSDIAGAWQRLEQAEKGYEEWLLN 391
Query: 671 GIKLREANQQ--QQFNRNVEDIELWLYEVEGHLASDDY-GKDLTNVQNLQKKHALLEADV 727
I+ E + ++F + E W Y E L DY LT V+ L +KH E+D+
Sbjct: 392 EIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDL 451
Query: 728 AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
AAHQDR++ I A++ + + DA N+ + + + +++ L R++ L +L
Sbjct: 452 AAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLL 511
Query: 788 QLFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA---EIAGH 836
+ + E W+ + +Q+L+ H+ +A E G
Sbjct: 512 ETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGE 571
Query: 837 EPRIKAVTQKGNAMVEEGHFAAEDVK----AKLHELNQKWEALKAKASQRRQDLEDSLQA 892
I A+ + +++ + + EL KW+ +K R Q L++ L
Sbjct: 572 RQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR 631
Query: 893 Q--------QYFADANEAESWMREK 909
Q Q+ A AN W++ K
Sbjct: 632 QHANERLRRQFAAQANAIGPWIQNK 656
Score = 71.2 bits (173), Expect = 1e-11
Identities = 111/557 (19%), Positives = 217/557 (38%), Gaps = 81/557 (14%)
Query: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF---------LNTEDKGDSLDSVEALI 1484
W QR+ + + +Q FH + A LN +D +++ +
Sbjct: 160 WCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIA 219
Query: 1485 KKHEDFDKAINVQE--------EKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL 1536
+KH D K ++ ++ E+ AG ++R +VL +
Sbjct: 220 EKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVL-AVNQE 278
Query: 1537 KAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQK 1596
+++E+ +L S+ L+ R + +E EK A + +D + + K Q+
Sbjct: 279 NERLMEEYERLA-SELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQE 337
Query: 1597 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKS 1656
+ +L N + ++ + + N R A SE + ++ +A WQ L Q AEK
Sbjct: 338 ----KCQLEINFNTLQTKLRISN----RPAFMPSEGKM---VSDIAGAWQRLEQ--AEKG 384
Query: 1657 QK---LKEANK-------QQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKH 1705
+ L E + + F + W E +L +DY L V LL+KH
Sbjct: 385 YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKH 444
Query: 1706 QLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKL 1765
+ E+D++AH+DR++ + + A L D V D+ I ++ ++ ++ RR L
Sbjct: 445 EAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL 504
Query: 1766 NESHRLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAE 1817
+L + + E +W++ + + +Q+L H++ +A
Sbjct: 505 ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT 564
Query: 1818 LAAHEPAIQGVL-----------DTGKKLSDDN---TIGKEEIQQRLAQFVEHWKELKQL 1863
L + Q ++ ++S N T+ +E++ + W ++KQL
Sbjct: 565 LPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTK-------WDKVKQL 617
Query: 1864 AAARGQRLEESLEYQ--------QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLK 1915
R Q L+E L Q QF A WI KM +A T A++ +
Sbjct: 618 VPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQIT-GALEDQMN 676
Query: 1916 KHEAFETDFTVHKDRVN 1932
+ + +E + +K+ ++
Sbjct: 677 QLKQYEHNIINYKNNID 693
Score = 69.3 bits (168), Expect = 4e-11
Identities = 78/301 (25%), Positives = 130/301 (43%), Gaps = 32/301 (10%)
Query: 153 QYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE---- 207
+Y R ++++WI + I E + + ++ +QKK E+F+ H+ +V E
Sbjct: 285 EYERLASELLEWI--RRTIPWLENRTPE-KTMQAMQKKLEDFRDYRRKHKPPKVQEKCQL 341
Query: 208 ---VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRL----KGLA------LQRQGKLFG 253
N KL P + K ++ AWQRL KG ++R +L
Sbjct: 342 EINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEH 401
Query: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLRKHEGLERDLAALEDKVK 312
AE R ET W KEQ++ D+ L V+ALLRKHE E DLAA +D+V+
Sbjct: 402 LAEKFRQKASTHET--WAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVE 459
Query: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372
+ A A L + A + + +++ W+++ TL +R L R+++ L
Sbjct: 460 QIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALE---RMEKLLETIDQ 516
Query: 373 L-TSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHED---SFKSADESGQALL 428
L + N E A + ++ +E + I AHE + AD Q+++
Sbjct: 517 LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576
Query: 429 A 429
A
Sbjct: 577 A 577
Score = 64.3 bits (155), Expect = 1e-09
Identities = 83/384 (21%), Positives = 166/384 (43%), Gaps = 55/384 (14%)
Query: 41 EDSYRFQFFQRDAEELEKWIQ-----------EKLQIASDENYKDPTNLQGKLQKHQAFE 89
E+ + ++R A EL +WI+ EK A + +D + + K + + E
Sbjct: 278 ENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQE 337
Query: 90 -AEVQANSGAI---VKLDETGNLMISEGHFASETIRT--RLMELHRQWE-LLLEKMREKG 142
+++ N + +++ M SEG S+ RL + + +E LL ++R
Sbjct: 338 KCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR--- 394
Query: 143 IKLLQAQKLVQYLRECEDVMD-WINDKEAIVTSEEL-GQDLEHVEVLQKKFEEFQTDMAA 200
+L + + L + R+ + W KE I+ ++ L V L +K E F++D+AA
Sbjct: 395 -RLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA 453
Query: 201 HEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGL------ALQRQGKLFGA 254
H++RV ++ A +L + + + + + ++ W RL L AL+R KL
Sbjct: 454 HQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLET 513
Query: 255 AEVQR--FNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHE----------GLER 302
+ F + +W++ + + + +Q+L+ HE G +
Sbjct: 514 IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573
Query: 303 DLAALEDKVKALCAEAD-RLQQSHPLSATQIQVKREELITNWEQIRTLA-------AERH 354
+ A++++V+ + + R+ S+P S V +EL T W++++ L E
Sbjct: 574 SIMAIQNEVEKVIQSYNIRISSSNPYST----VTMDELRTKWDKVKQLVPIRDQSLQEEL 629
Query: 355 ARLNDSYRLQR-FLADFRDLTSWV 377
AR + + RL+R F A + W+
Sbjct: 630 ARQHANERLRRQFAAQANAIGPWI 653
Score = 63.2 bits (152), Expect = 3e-09
Identities = 47/207 (22%), Positives = 84/207 (40%), Gaps = 17/207 (8%)
Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
+ ++ W+ L+Q L E +L H ++F + A + W K Q L
Sbjct: 368 VSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQK 427
Query: 1260 NY-GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
+Y L V+AL RKHE FE DLAA D+V + A+ L + A ++ ++C ++
Sbjct: 428 DYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487
Query: 1319 QAWSSLGKRADQRKAKLGDSHDL--------QRFLSDFRDLMSWINGIRGLVSSDELAKD 1370
W LG +R+ L L F +W+ G + +
Sbjct: 488 DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547
Query: 1371 VTGAEALLERHQEHRTEIDARAGTFQA 1397
+ ++L+ H++ + + G Q+
Sbjct: 548 IEEIQSLITAHEQFKATLPEADGERQS 574
Score = 62.0 bits (149), Expect = 7e-09
Identities = 74/342 (21%), Positives = 148/342 (43%), Gaps = 37/342 (10%)
Query: 357 LNDSYRLQRF--LAD-FRDLTS----WVT-EMKALINADELASDVAGAEALLDRHQEHKG 408
LN+ RL+R LA+ FR S W + + L+ D ++ + ALL +H+ +
Sbjct: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449
Query: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468
++ AH+D + Q L ++ + V ++ + ++ L L + RR+ E+
Sbjct: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509
Query: 469 L-----QL---FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL---S 517
L QL F + +NWM L + + S++ +++L+ HE F+ +L
Sbjct: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569
Query: 518 AQEEKITALDEFATKLIQ--------NNHYA---MEDVATRRDALLS----RRNALHERA 562
+ + I A+ K+IQ +N Y+ M+++ T+ D + R +L E
Sbjct: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629
Query: 563 MRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELS 622
R Q A+ +QF ++ + W+ KM+ + + L+ ++ + + +E +
Sbjct: 630 AR---QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNII 686
Query: 623 ANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
++ ID LE Q + + + M + W+ LL
Sbjct: 687 NYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLL 728
Score = 58.5 bits (140), Expect = 8e-08
Identities = 69/318 (21%), Positives = 134/318 (42%), Gaps = 32/318 (10%)
Query: 480 DNWMSKQEAFLLNEDLGD-SLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH 538
+ W +E LL +D SL V ALL+KHE FE L+A ++++ + A +L + ++
Sbjct: 414 ETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDY 473
Query: 539 YAMEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWV 589
+ +V R + + + L +RR L D HL +F + + +W+
Sbjct: 474 HDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHL-EFAKRAAPFNNWM 532
Query: 590 NEKMKTATDE-AYKDPSNLQGKVQKHQAFEA---ELSANQSRIDALEKAGQKLIDVNHY- 644
M+ D +Q + H+ F+A E + I A++ +K+I +
Sbjct: 533 EGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIR 592
Query: 645 ---AKDEVAARMNEVISLWKKLLEATELKGIKLRE------ANQ--QQQFNRNVEDIELW 693
+ M+E+ + W K+ + ++ L+E AN+ ++QF I W
Sbjct: 593 ISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652
Query: 694 LYEVEGHLA--SDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFD 751
+ +A S L + N K++ E ++ +++ ID + + Q+A FD
Sbjct: 653 IQNKMEEIARSSIQITGALEDQMNQLKQY---EHNIINYKNNIDKLEGDHQLIQEALVFD 709
Query: 752 AENIKKKQEALVARYEAL 769
++ E + +E L
Sbjct: 710 NKHTNYTMEHIRVGWELL 727
Score = 51.2 bits (121), Expect = 1e-05
Identities = 65/374 (17%), Positives = 145/374 (38%), Gaps = 28/374 (7%)
Query: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
PS K++ +R +Q Y + R ++LE + + F++ A E W
Sbjct: 362 PSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLE--HLAEKFRQKASTHETWAYG 419
Query: 63 KLQIASDENYKDP--TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
K QI ++Y+ T ++ L+KH+AFE+++ A+ + ++ + + + +
Sbjct: 420 KEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNV 479
Query: 121 RTRLMELHRQWE---LLLEKMR---EKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172
R ++ QW+ L +K R E+ KLL+ Q +++ + +W+ +
Sbjct: 480 NDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDL 539
Query: 173 TSEELGQDLEHVEVLQKKFEEFQTDMA---AHEERVNEVNQFAAKLIQEQH----PEEEL 225
+ +E ++ L E+F+ + + + + K+IQ +
Sbjct: 540 QDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPY 599
Query: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277
DE+ W ++K L R L Q N + + WI+ K +
Sbjct: 600 STVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEE 659
Query: 278 MASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKRE 337
+A + +++ + + + E ++ ++ + L + +Q++ E
Sbjct: 660 IARSSI-QITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTME 718
Query: 338 ELITNWEQIRTLAA 351
+ WE + T A
Sbjct: 719 HIRVGWELLLTTIA 732
Score = 42.4 bits (98), Expect = 0.006
Identities = 47/198 (23%), Positives = 86/198 (43%), Gaps = 17/198 (8%)
Query: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKH---- 826
E ++ ++LA L L+ + R + W+ + P K L ++ +KH
Sbjct: 280 ERLMEEYERLASEL-LEWIRRTIP----WLENRTPEKTMQAMQKKLEDFRDYRRKHKPPK 334
Query: 827 --QALQAEIAGHEPRIKA-VTQKGNAMVEEGHFAAEDVKA--KLHELNQKWEALKAKASQ 881
+ Q EI + + K ++ + M EG ++ A +L + + +E +
Sbjct: 335 VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR 394
Query: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLS 940
R + LE A+++ A+ E+W KE I+ DY ALL+KHEA SDL+
Sbjct: 395 RLERLEHL--AEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLA 452
Query: 941 AYGSSIQALREQAQSCRQ 958
A+ ++ + AQ +
Sbjct: 453 AHQDRVEQIAAIAQELNE 470
Score = 40.4 bits (93), Expect = 0.022
Identities = 81/428 (18%), Positives = 158/428 (36%), Gaps = 62/428 (14%)
Query: 1235 VQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFE-----------RDLA 1283
++ + R A E EWI L ++QA+Q+K E F ++
Sbjct: 283 MEEYERLASELLEWIRRTIPWLENRT---PEKTMQAMQKKLEDFRDYRRKHKPPKVQEKC 339
Query: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS----H 1339
L N+L +T R I + P + +++ AW L + + L +
Sbjct: 340 QLEINFNTL-QTKLR-ISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLE 397
Query: 1340 DLQRFLSDFRDLMS----WINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGT 1394
L+ FR S W G L+ D + +T ALL +H+ +++ A
Sbjct: 398 RLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457
Query: 1395 FQAFEQFGQQLLAHGHYASPEIK----------QKLDILDQERADLEKAWVQRRMMLDQC 1444
+ Q+L ++ + + +L L Q+R + + + +DQ
Sbjct: 458 VEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQ- 516
Query: 1445 LELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDF-----------DKA 1493
L L+ F + NWM L S++ +++LI HE F
Sbjct: 517 LHLE-FAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI 575
Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTL 1553
+ +Q E +Q++ ++ ++ Y+ + +E+ +W ++K + + L E
Sbjct: 576 MAIQNEVEKVIQSYNIRISSSNPYS----TVTMDELRTKWDKVKQLVPIRDQSLQEELAR 631
Query: 1554 Q--------QFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
Q QF+ + I WI K++ + S + ++ K +H +
Sbjct: 632 QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYK-- 689
Query: 1606 ANADRIRG 1613
N D++ G
Sbjct: 690 NNIDKLEG 697
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 280 bits (717), Expect = 1e-74
Identities = 168/521 (32%), Positives = 283/521 (54%), Gaps = 39/521 (7%)
Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
+F KA + E+W KE L+ DY LS ++ LL K E F++ L A Q+ + I A
Sbjct: 398 KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRVEQIAA 456
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
+ +L + S ++ AR + +W L A + R++ L + ++ L+L +AK
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA------E 2157
+A+ FN+W E A EDL D +++EEI+ L AH+ F+++L A D +LA E
Sbjct: 517 RAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA--DKERLAILGIHNE 574
Query: 2158 LDRQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQE 2214
+ + ++++ V +NPYT T + + W ++++++ R+ L +E RQ+ N++LR++
Sbjct: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
Query: 2215 FAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
F AN WIQ + G +E GTLE QL ++ + I + ++ ++E
Sbjct: 635 FGAQANVIGPWIQTKMEEI--GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
Query: 2275 AAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFS 2334
++EALI DNK+T ++ + W+QL R + +E QI R+ G+++E + EF
Sbjct: 693 QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR 752
Query: 2335 MMFKHFDKDKSGRLNHQEFKSCLRSLGYDL---PMVEEGEPD-----------------P 2374
F HFD+D SG L +EFK+CL SLGYD+ P + G D
Sbjct: 753 ASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEA 812
Query: 2375 EFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEEL 2434
EF I+ VDPNR G V+ Q ++ FM SRET + +++++ ++F+ L+ + K Y+T +EL
Sbjct: 813 EFARIMSIVDPNRLGVVTFQAFIDFM-SRETADTDTADQVMASFKILAGD-KNYITMDEL 870
Query: 2435 YQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLF 2475
+ L +QA+YC++ M PY +P A DY+ F+ +L+
Sbjct: 871 RRELPPDQAEYCIARMAPYTGPD--SVPGALDYMSFSTALY 909
Score = 83.6 bits (205), Expect = 2e-15
Identities = 83/382 (21%), Positives = 162/382 (42%), Gaps = 47/382 (12%)
Query: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFT 1925
R +RL+ E +F EAW + K ++ +DY TL+ I+ LLKKHEAFE+D
Sbjct: 388 RLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE 1979
H+DRV + Q+L + + + +++++ + + G ++ + A +R KL E
Sbjct: 446 AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505
Query: 1980 --NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
+ +L++ +A +W+ L+ + +Q L T E F A L +E
Sbjct: 506 TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565
Query: 2038 IANITALKDQLLAAKHVQSKAIEARHASLM--------------KRWSQLLANSAARKKK 2083
+A +L + SK ++ H ++ +W + R +
Sbjct: 566 LA--------ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA 617
Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDA 2140
L E + + E L F +A+ W + E+ ++ + +++ LR+
Sbjct: 618 LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ---- 673
Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL----QKIIKEREL 2196
+ S+ + + +QL + I+ + N +T +TME + W L + I E E
Sbjct: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733
Query: 2197 ELQKEQRR---QEENDKLRQEF 2215
++ + QE+ ++ R F
Sbjct: 734 QILTRDAKGISQEQMNEFRASF 755
Score = 60.8 bits (146), Expect = 2e-08
Identities = 88/425 (20%), Positives = 167/425 (39%), Gaps = 66/425 (15%)
Query: 357 LNDSYRLQRF--LAD-FRDLTS----WVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408
LN+ RL+R LA+ FR S W +A++ D + ++ +ALL +H+ +
Sbjct: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFES 442
Query: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468
++ AH+D + Q L +Y S V + + ++ L L + RR+ E+
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
Query: 469 L-----QLFYRDTEQV---DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQ 519
L QL+ ++ +NWM L + + +++ ++ L HE F+ +L A
Sbjct: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
Query: 520 EEK--ITALDEFATKLIQNNHYAM---------------------EDVATRRDALLSRRN 556
+E+ I + +K++Q H M + RRD L+ +
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
Query: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
A + R R +QF ++ + W+ KM+ + + L+ ++ +
Sbjct: 623 ARQQHNERLR---------KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ 673
Query: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLE----------- 665
+E + + +ID LE Q + + + M + W++LL
Sbjct: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733
Query: 666 ---ATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHA 721
+ KGI + N+ + FN D L E G D+ N + QKK
Sbjct: 734 QILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGN--DPQKKTG 791
Query: 722 LLEAD 726
+++ D
Sbjct: 792 MMDTD 796
Score = 60.1 bits (144), Expect = 3e-08
Identities = 50/250 (20%), Positives = 110/250 (44%), Gaps = 14/250 (5%)
Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
++R LD E F + E W +EA L +D + +L ++AL+KKHE F+
Sbjct: 386 IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKA------QMIEKRSKL 1547
+ ++++ + A A +L +Y +++R ++ D+W L A + +E+ KL
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
E+ Q ++++ W+ ++ D ++ T ++ L + H++ +A +
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQD-TFIVHTIEEIQGLTTAHEQFKATLPDAD 562
Query: 1606 ANADRIRGVIDMGNSLIE--RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
I G+ + + +++ AG+ + +W + Q + Q L E +
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
Query: 1664 KQQNFNTGIK 1673
+Q N ++
Sbjct: 623 ARQQHNERLR 632
Score = 58.9 bits (141), Expect = 6e-08
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 9/137 (6%)
Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
+ ++N W L+Q L E +L H ++F + A + W + K L
Sbjct: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
Query: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
+Y L+ ++AL +KHE FE DLAA D+V + A+ L + + + +C ++
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
Query: 1319 QAWSSLGKRADQRKAKL 1335
W +LG +R+ L
Sbjct: 481 DQWDNLGALTQKRREAL 497
Score = 57.4 bits (137), Expect = 2e-07
Identities = 84/389 (21%), Positives = 154/389 (39%), Gaps = 44/389 (11%)
Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
Q++E KL S L+ R + +E + E A + +D + + L K K Q
Sbjct: 274 QLMEDYEKLA-SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY---RRLHKPPKVQ 329
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657
+ +L N + ++ + + N R A SE + ++ + + W L Q + +
Sbjct: 330 E-KCQLEINFNTLQTKLRLSN----RPAFMPSEGRM---VSDINNAWGCLEQVEKGYEEW 381
Query: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLE 1709
L E + + + + F + W EA+L +DY L+ + LLKKH+ E
Sbjct: 382 LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
Query: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769
+D++AH+DR++ + + A L +D+ V + I ++ + ++ RR L +
Sbjct: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
Query: 1770 RLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821
+L + + E +W++ + + +Q L H++ +A L
Sbjct: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
Query: 1822 EP---AIQGVLDTGKKLSDD---NTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEES 1874
+ AI G+ + K+ N G Q + W ++QL R Q L E
Sbjct: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
Query: 1875 LEYQ--------QFVANVEEEEAWINEKM 1895
Q QF A WI KM
Sbjct: 622 HARQQHNERLRKQFGAQANVIGPWIQTKM 650
Score = 57.0 bits (136), Expect = 2e-07
Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 25/235 (10%)
Query: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE 207
Q + Y + D+++WI + + ++ H +Q+K E+F+ H+ +V E
Sbjct: 274 QLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHA--MQQKLEDFRDYRRLHKPPKVQE 330
Query: 208 -------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRLKGLA----------LQRQG 249
N KL P + + ++N AW L+ + ++R
Sbjct: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALE 308
+L AE R + E +W KE ++ D+ L+ ++ALL+KHE E DLAA +
Sbjct: 391 RLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
Query: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
D+V+ + A A L + + + + +++ W+ + L +R L + +L
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/347 (19%), Positives = 143/347 (41%), Gaps = 31/347 (8%)
Query: 32 LSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPT--NLQGKLQKHQAFE 89
L+ +RR + D +F Q+ A E W K + ++Y+ T ++ L+KH+AFE
Sbjct: 383 LNEIRRLERLDHLAEKFRQK-ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
Query: 90 AEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE---LLLEKMR---EKGI 143
+++ A+ + ++ + ++ S ++ R ++ QW+ L +K R E+
Sbjct: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
Query: 144 KLLQA--QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMA-A 200
KLL+ Q ++Y + +W+ + + +E ++ L E+F+ + A
Sbjct: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
Query: 201 HEER--VNEVNQFAAKLIQEQHPE----EELIKTKQDEVNAAWQRLKGLALQRQGKLFGA 254
+ER + ++ +K++Q H E+N W ++ L +R L
Sbjct: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
Query: 255 AEVQRFNRDVDETIS--------WIKEKEQLMA--SDDFGRDLASVQALLRKHEGLERDL 304
Q+ N + + WI+ K + + S + L + LR++ E+ +
Sbjct: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQY---EKSI 678
Query: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
+ K+ L + +Q++ E + WEQ+ T A
Sbjct: 679 VNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
Score = 57.0 bits (136), Expect = 2e-07
Identities = 57/286 (19%), Positives = 118/286 (41%), Gaps = 31/286 (10%)
Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
++F + E W E L DY L+ ++ L KKH E+D+AAHQDR++ I
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQLFRDV 793
A++ + ++D+ ++ + + + +++ L + + R +KL ++ + QL+ +
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET--IDQLYLEY 514
Query: 794 EDE----ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR---IKAVTQK 846
W+ T + +Q L H+ +A + + I + +
Sbjct: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE 574
Query: 847 GNAMVEEGHFAAEDVKAKL----HELNQKWEALKAKASQRRQDLEDSLQAQ--------Q 894
+ +V+ H E+N KW+ ++ +R Q L + Q Q
Sbjct: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
Query: 895 YFADANEAESWMREKEPIVGSTD---YGKDEDSAEALLKKHEALMS 937
+ A AN W++ K +G +G ED L + +++++
Sbjct: 635 FGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVN 680
Score = 54.3 bits (129), Expect = 1e-06
Identities = 65/317 (20%), Positives = 127/317 (40%), Gaps = 34/317 (10%)
Query: 482 WMSKQEAFLLNEDLGDS-LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
W +EA L +D + L ++ALLKKHE FE L+A ++++ + A +L + ++Y
Sbjct: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWVNE 591
V R + + + L +RR L D +L ++ + + +W+
Sbjct: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYL-EYAKRAAPFNNWMEG 527
Query: 592 KMKTATDE-AYKDPSNLQGKVQKHQAFEAEL-SANQSRIDAL--EKAGQKLIDVNHY--- 644
M+ D +QG H+ F+A L A++ R+ L K++ H
Sbjct: 528 AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA 587
Query: 645 -AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVED--------IELWL- 694
E+ W + + + L E + +QQ N + I W+
Sbjct: 588 GTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQ 647
Query: 695 --YEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDA 752
E G ++ + +G + +L++ E + ++ +ID + + Q+A FD
Sbjct: 648 TKMEEIGRISIEMHGTLEDQLSHLRQ----YEKSIVNYKPKIDQLEGDHQLIQEALIFDN 703
Query: 753 ENIKKKQEALVARYEAL 769
++ E + +E L
Sbjct: 704 KHTNYTMEHIRVGWEQL 720
Score = 51.6 bits (122), Expect = 9e-06
Identities = 65/326 (19%), Positives = 136/326 (41%), Gaps = 54/326 (16%)
Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093
N L+ + ++ R + ++ R+ + + ++QVE+ Y L +R L+ +K
Sbjct: 339 NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
Query: 1094 FMLFREANELQQWINEKEAALTSEEVG-ADLEQVEVLQKKFDDFQKDLKANESRLKDINK 1152
F ++A+ + W + KEA L ++ A L +++ L KK + F+ DL A++ R++ I
Sbjct: 399 FR--QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 1153 VAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELN 1212
+A++L + + Y SP +AR +++
Sbjct: 457 IAQELN-------------ELDYYD------------SPSVNARC-----------QKIC 480
Query: 1213 ERWRSLQQLAEERSQLLGSAHEVQR--------FHRDADETKEWIEEKNQALNTDNYGHD 1264
++W +L L ++R + L ++ + + A W+E + L H
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
Query: 1265 LASVQALQRKHEGFERDLA-ALGDKVNSLG--ETAERLIQSHPESAEDLQEKCT----EL 1317
+ +Q L HE F+ L A +++ LG +++Q++ + T E+
Sbjct: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
Query: 1318 NQAWSSLGKRADQRKAKLGDSHDLQR 1343
N W + + +R L + H Q+
Sbjct: 601 NGKWDHVRQLVPRRDQALTEEHARQQ 626
Score = 48.5 bits (114), Expect = 8e-05
Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 8/114 (7%)
Query: 776 RKQKLADSLRLQQLFRDV--EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEI 833
R LA+ R + + + +E +R+K+ A+ + ++ LLKKH+A ++++
Sbjct: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE------IKALLKKHEAFESDL 444
Query: 834 AGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
A H+ R++ + + E ++ + V A+ ++ +W+ L A +RR+ LE
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
Score = 40.4 bits (93), Expect = 0.022
Identities = 55/290 (18%), Positives = 115/290 (39%), Gaps = 32/290 (11%)
Query: 1315 TELNQAWSSLGK-RADQRKAKLGDSHDLQRF---LSDFRDLMS----WINGIRGLV-SSD 1365
+++N AW L + + L + L+R FR S W +G ++ D
Sbjct: 362 SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKD 421
Query: 1366 ELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQ 1425
++ +ALL++H+ +++ A + Q+L +Y SP + + +
Sbjct: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
Query: 1426 ERADLEKAWVQRRMMLDQCLEL-----QLFHRDCEQA---ENWMAAREAFLNTEDKGDSL 1477
+ +L +RR L++ +L QL+ ++A NWM L ++
Sbjct: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
Query: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAAL----------QAFADQLIAAGHY---AKGDIS 1523
+ ++ L HE F + + +E++A L Q + + Y +I+
Sbjct: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
Query: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQ 1572
+ + V R + E+ ++ ++ L +QF + I WI K++
Sbjct: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKME 651
Score = 38.5 bits (88), Expect = 0.083
Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA-EALLKKHEALMSDLS 940
RR + D L A+++ A+ E+W KE ++ DY S +ALLKKHEA SDL+
Sbjct: 387 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
Query: 941 AYGSSIQALREQAQSCRQ 958
A+ ++ + AQ +
Sbjct: 446 AHQDRVEQIAAIAQELNE 463
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 278 bits (711), Expect = 5e-74
Identities = 415/1966 (21%), Positives = 824/1966 (41%), Gaps = 178/1966 (9%)
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASET--IRTRLMELHRQ 130
+D LQ + + +AF +++A + ++T +M++ + + I+ L L +Q
Sbjct: 3145 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 3204
Query: 131 WELLLEKM--REKGIK--LLQAQKLVQYLRECEDVMDWINDKEAI-----VTSEELGQDL 181
LL++ RE+ ++ + + ++ L+E ++ + E + +E + Q L
Sbjct: 3205 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 3264
Query: 182 EHVEVLQKKFEEFQTDMAAHEERVNEVNQ----FAAKLIQEQHPEEELIKTKQDEVNAAW 237
+V QK EE + + ++ VN + Q AAK Q E +L D+VNA W
Sbjct: 3265 NMFKVFQK--EEIEP-LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL-----DDVNARW 3316
Query: 238 QRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLR 295
+ L QR +L A RF ++ +SW+ + E+L+A+ + V+A ++
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3376
Query: 296 KHEGLERDLAALEDKVKALCAEADRLQQS-HPLSATQIQVKREELITNWEQIRTLAAERH 354
+ + L+R L + V+ + E +++ + P +I + L + WE + A R+
Sbjct: 3377 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3436
Query: 355 ARLND-SYRLQRFLADFRDLTSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDA 412
+L S Q+F L W+T + K L+N + + + + E + +H+ + +I
Sbjct: 3437 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3496
Query: 413 HEDSFKSADESGQAL-LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-DLQ 470
H A GQ+L + + D V+ KL + E R + +Q + + +
Sbjct: 3497 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3556
Query: 471 LFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLSAQEEKITAL 526
+F D ++ NW+++ L + D S E L K+ + E L ++ AL
Sbjct: 3557 IFGEDEVELMNWLNEVHDKLSKLSVQDY--STEGLWKQQSELRVLQEDILLRKQNVDQAL 3614
Query: 527 DEFATKLIQNNHYAMEDVATRRDALLSRRNALHE------RAMRRRAQLADSFHLQQFFR 580
L Q + + + +A+ +R + + + + + QLA H
Sbjct: 3615 LNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTH--- 3671
Query: 581 DSDELKSWVNE---KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
+EL +W+++ ++ + + K Q +++ + + E N++ +D+L +
Sbjct: 3672 --EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNEVSSA 3728
Query: 638 LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN--QQQQFNRNVEDIELWLY 695
L+++ + E +M + +L+ T + ++ +A + QQF++ + W+
Sbjct: 3729 LLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT 3788
Query: 696 EVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA-GHFD 751
E E L S +D T+ Q +K +E + H+D ID + + A +
Sbjct: 3789 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHKIMTACSEEE 3846
Query: 752 AENIKKKQEALVARYEALKEPMVARKQKL--ADSLRLQQLFRDVEDEETWIREKEPIAAS 809
+++KKK + ++ Y+ + + R +L A SL + Q + E+ W+ E + I +
Sbjct: 3847 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETYEELWPWLTETQSIISQ 3905
Query: 810 TNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
+ ++ ++H+ L+ IA H+P I + + G ++E ++ K
Sbjct: 3906 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA 3965
Query: 869 NQKWEALKAKASQRRQDLEDSLQAQQYFADANEA--ESWMREKEPIVGSTDYGKDEDSAE 926
+ + +K +R L++++ F D + ES R E + + + +
Sbjct: 3966 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4025
Query: 927 ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ----EKS 982
+ +++ + D+ + L+++ + + TD + + V D E
Sbjct: 4026 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4085
Query: 983 PREVTMKKGDILTLLNSTNKDWWK-----VEVNDRQGFVPAAYVKKLDPA----QSASRE 1033
V ++ +L ++ K W V + D Q F+ +DP+ Q + E
Sbjct: 4086 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4145
Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVS------LRMKQVEEL---YHSLLELGEKRK 1084
+ EE + QE++D + E + + K ++EL + SL + + R
Sbjct: 4146 TIREEIDGL---QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4202
Query: 1085 GMLEKSCKKFMLFREANE-LQQWINEKEAALTS-EEVGADLEQVEVLQKKFDDFQKDLKA 1142
LE++ + + +++ + + W++ L S +G DLE V+ ++ F+ +
Sbjct: 4203 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4262
Query: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
+ ++ +N AE L+ ++V +E+D HTV
Sbjct: 4263 QQIEMERLNHQAE------LLLKKVT-------------EESDK-------------HTV 4290
Query: 1203 ATFNSIKELNERWRSLQQ-LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN- 1260
+ + EL W SL++ + + +L G+ + +F DE W+ L+
Sbjct: 4291 Q--DPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4348
Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTELNQ 1319
G D +++ KH + D+ A V ++ + LI+S E A +LQ K LNQ
Sbjct: 4349 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4408
Query: 1320 AWSSLGKRADQRKAKL-GDSHDLQRFLSDFRDLMSWINGI-RGLVSSDELAKDVTGAEAL 1377
W ++ ++ +QRK +L G + F + DL W+ R L++S L A+
Sbjct: 4409 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4468
Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQ 1436
L H E +A+ T+++ Q GQQ+LA A I Q ++ L ++ +E +
Sbjct: 4469 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4528
Query: 1437 RRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAI 1494
R+ L++ L L + FH + NW+ E LN + LD+V I +H+ F +
Sbjct: 4529 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4588
Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRN---EVLDRWRRLKAQMIEKRSKLGESQ 1551
N E+I L L K D+ +N V RW ++ +++E+ L +++
Sbjct: 4589 NSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4646
Query: 1552 T-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
+QF ++ W+ SEK + E DP I+ L++H++ Q H+
Sbjct: 4647 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ--LAQHKEFQKSLGAKHSVY 4704
Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK-QQN 1667
D G SL E+ + A + L+ L D+W + KS E+ KL+EA
Sbjct: 4705 DTTNRT---GRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4761
Query: 1668 FNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
F ++ WL VE LA + +G D+ V NL+ H+ + ++ ++ L
Sbjct: 4762 FTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4820
Query: 1726 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR--------LHQFFRD 1777
A L+ S D+S VK + ++ R++ + +++ S++ +L + R +H
Sbjct: 4821 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4880
Query: 1778 MDDEESWIKEKKLLVGSEDYGRDLTGV-QNLRKKHKRLEAELAAHEPAIQGVL-----DT 1831
+ + E ++ +L ED R L + KK + AEL VL D+
Sbjct: 4881 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 4940
Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA---ARGQRLEESLEYQQFVANVEEEE 1888
+ TI + ++ LA +H + L A A+ + LE L + Q
Sbjct: 4941 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQ--------- 4991
Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
W +T E + ++ L+ +H+ F + T + V+ V
Sbjct: 4992 -WAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5036
Score = 265 bits (676), Expect = 5e-70
Identities = 503/2529 (19%), Positives = 1024/2529 (40%), Gaps = 298/2529 (11%)
Query: 49 FQRDAEELEKWIQEKLQIASDENYKDPTN-----LQGKLQKHQAFEAEVQANSGAIVK-L 102
FQ+ + + + W+ K + ++N P + L+ ++ H+ F + A S K +
Sbjct: 2794 FQQMSRDFQAWLDTKKE---EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2850
Query: 103 DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA-QKLVQYLRECEDV 161
E NL++ ++ +L + W+ ++++E+ KL ++ +K ++Y + E +
Sbjct: 2851 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2910
Query: 162 MDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
WI+ + + + D E K + Q +M H V +N A L+
Sbjct: 2911 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2970
Query: 222 EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE-----KEQ 276
++E++ DE + Q++ + Q K F + + ++ E K KEQ
Sbjct: 2971 DKEVVT---DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQ 3027
Query: 277 LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
L D G S L + ++ L AL+ +V A RL Q + A+ +
Sbjct: 3028 LDIHDSLGSQAYS-NKYLTMLQTQQKSLQALKHQVDL----AKRLAQDLVVEASDSKGTS 3082
Query: 337 EELITNWEQIRTLAAERHARLNDSY---------RLQ---RFLADFRDLTSWVTEMKALI 384
+ L+ Q+ T+A E H+ L+ +LQ F R++ S E +
Sbjct: 3083 DVLL----QVETIAQE-HSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDEL 3137
Query: 385 NADELASDVAGAEALLDRHQEHKG---EIDAHEDSFKSADESGQALLAAGHYASDEV--R 439
D +A AE L + + K +++A S +A+++ + +LA + D V +
Sbjct: 3138 --DSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3195
Query: 440 EKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDTEQVDNWMSKQEAFLLNED-LGD 497
L LS++ LL+ + R +Q E + L+ FY ++ + K E ++ +G
Sbjct: 3196 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 3255
Query: 498 SLDSVEALLKKHEDFEKS----LSAQEEKITALDEFATKLIQNNHYAMEDVATRR----- 548
+++ L + F+K L +++ + L + LIQ+ A + +T+
Sbjct: 3256 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ---GLIQS---AAKSTSTQGLEHDL 3309
Query: 549 DALLSRRNALHERAMRRRAQLADSF-HLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN- 606
D + +R L+++ +R AQL ++ H +F + L SW+ + + ++ K PS
Sbjct: 3310 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ--KPPSAE 3367
Query: 607 ---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA-KDEVAARMNEVISLWKK 662
++ ++Q+ + + L +S ++ +++ G+K+ A K ++ +++ + S W+
Sbjct: 3368 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3427
Query: 663 LLEATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLAS-DDYGKDLTNVQNLQKKH 720
LL E + +L + QQF+ +E + WL +E L + + G + ++ +H
Sbjct: 3428 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3487
Query: 721 ALLEADVAAHQDRI-DGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
LE D+ H + ++I + D + ++ K + Y ++E +R +
Sbjct: 3488 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3547
Query: 780 LADSLRLQQLFRDVEDE-ETWIRE-KEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHE 837
L +L ++F + E E W+ E + ++ + + G+ + + LQ +I +
Sbjct: 3548 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3607
Query: 838 PRIKAVTQKGNAMVEEGHFAAEDV---KAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQ 893
+ G ++++ ++V + KL + +++ + ++ + LE +LQ A+
Sbjct: 3608 QNVDQALLNGLELLKQT--TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3665
Query: 894 QYFADANEAESWMR--EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
+ + E +W+ E E + T K E++++A ++ E L + + + +L E
Sbjct: 3666 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNE 3724
Query: 952 QAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVND 1011
S ++ P G E ++A + + L++ T KVE D
Sbjct: 3725 -VSSALLELVPWRAREGLEKMVA--------------EDNERYRLVSDTITQ--KVEEID 3767
Query: 1012 RQGFVPAAYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITK------------ 1057
+ + D S E L G I L Q+Q Q ++ K
Sbjct: 3768 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3827
Query: 1058 ------------------EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
E S+ ++ +V + Y ++ ++ +R LE++ F E
Sbjct: 3828 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3887
Query: 1100 A-NELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL 1157
EL W+ E ++ ++ A + E + Q++ ++ + ++ + +NK L
Sbjct: 3888 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3947
Query: 1158 ----ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNE 1213
EG +E + V +Y + D + VA +I + +
Sbjct: 3948 LELSPGEGFSIQE-KYVAADTLYSQIKED--------------VKKRAVALDEAISQSTQ 3992
Query: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
+ Q+ E +++ + + ++ KE I E N D+ +Q L
Sbjct: 3993 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK------NVSVDMEKLQPLYE 4046
Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
L G+++ + ++ I SA+ +Q+K ++ W ++ ++R+A
Sbjct: 4047 T-------LKQRGEEMIARSGGTDKDI-----SAKAVQDKLDQMVFIWENIHTLVEEREA 4094
Query: 1334 KLGDSHDL-QRFLSDFRDLMSWINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDAR 1391
KL D +L ++F D L+ I + + ++ D + + E + R EID
Sbjct: 4095 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 4154
Query: 1392 AGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
G +L+A G P +K+ +D L+ L KAW R L++ ++ +
Sbjct: 4155 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 4214
Query: 1451 HRDCEQAE-NWM-AAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508
++D QA +W+ A + G L++V+ I++ + F Q+ ++ L A
Sbjct: 4215 YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQA 4274
Query: 1509 DQLI--AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEA 1565
+ L+ K + E+ W L+ ++I ++ KL G L QF +DE+ A
Sbjct: 4275 ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 4334
Query: 1566 WIS--EKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1623
W++ E L + DP I++ KH + ++ A+ + V GN LIE
Sbjct: 4335 WLTHTEGLLSEQKPVGGDPKAIEIELA-----KHHVLQNDVLAHQSTVEAVNKAGNDLIE 4389
Query: 1624 RGACAGSEDA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSE 1681
+ AG E + ++ +L L +WQ +++K+ ++ Q+L A +Q + F+ I+D WL++
Sbjct: 4390 --SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4447
Query: 1682 VEA-LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDT-SQ 1739
E LLAS+ G + L H + A A E+ K L + ++ +
Sbjct: 4448 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4507
Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLH-QFFRDMDDEESWIK--EKKLLVGSED 1796
+ + + +++ +++ R+ KL E+ L +F + D +W+ E+ L V S
Sbjct: 4508 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4567
Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE---IQQRLAQF 1853
L V +HK E+ +H I + TG L + K++ I+ L
Sbjct: 4568 -SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISV 4624
Query: 1854 VEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQ 1911
W+++ Q RG+ L+++ + +QF + W+ E + SE + + I+
Sbjct: 4625 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4684
Query: 1912 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENIS--SKMKGLNGKVSDLEKA 1969
L +H+ F+ + G+ L +K + ++N+ + L K +
Sbjct: 4685 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4744
Query: 1970 AAQRKAKLDENSAFL-QFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTKQETF 2026
+ +R+ KL+E F QF + W+ E L D +G D+ V L+ + F
Sbjct: 4745 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAF 4803
Query: 2027 DAGLQAFQQEGIANITALKD---QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKK 2083
L + +++ ALK +L+ S ++ + L RW + A S +++ +
Sbjct: 4804 QKELG----KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4859
Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLT-DPVRCNSLEEIKALREAHDAFR 2142
L ++ R+ E+ F A W AE+ L V + + ++ L + H F
Sbjct: 4860 L---EAALRQAEE----FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4912
Query: 2143 SSLSSAQADFNQLAELDRQIKSFRVASNPYT---WFTM------EALEETWRNLQK---- 2189
L +A+ N+ + + + + T W T+ E L ++ Q+
Sbjct: 4913 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4972
Query: 2190 ----IIKERELELQKEQRRQEEN---DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEE 2242
I K+ LE + E DK ++ Q I E +T++ + M +
Sbjct: 4973 LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEE---MTRK 5029
Query: 2243 SGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVG-------- 2294
++ + KR+ + +++S + + D G A + + Y S
Sbjct: 5030 QPDVDKVTKTYKRRAADPSSLQSHIPVL-DKGRAGRKRFPASSLYPSGSQTQIETKNPRV 5088
Query: 2295 --LAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM---------------- 2336
L +W Q+ L + + L + E L+EF+
Sbjct: 5089 NLLVSKWQQVWLLALERRRKLNDALDRL-------EELREFANFDFDIWRKKYMRWMNHK 5141
Query: 2337 -------FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2389
F+ DKD+ G++ QEF + S + + E A+ D D + DG
Sbjct: 5142 KSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL-------EMSAVADIFDRDGDG 5194
Query: 2390 HVSLQEYMA 2398
++ E++A
Sbjct: 5195 YIDYYEFVA 5203
Score = 233 bits (594), Expect = 2e-60
Identities = 446/2453 (18%), Positives = 976/2453 (39%), Gaps = 266/2453 (10%)
Query: 21 QVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIAS--DENYKDPTN 77
++ ++ +L+ R+QKLE+S FQ +L++W+ EK + S DP
Sbjct: 2544 EIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2603
Query: 78 LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTRLMELHRQWELL 134
L + Q+ Q E +L G ++S E ++ +L + ++W+ L
Sbjct: 2604 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2663
Query: 135 LEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSEE-LGQDLEHVE 185
++ ++ +K Q Q L++ L + D+ + ++ A+ T + + Q LE +
Sbjct: 2664 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2723
Query: 186 VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNA---AWQRLKG 242
++++ ++ + + + +++ L++E++ + EL + + + + Q+ +
Sbjct: 2724 KMKQEIQQEKKQIKVAQALCEDLSA----LVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2779
Query: 243 LALQRQGKLFGAAEVQRFNRDVDETISWIK-EKEQLMASDDFGRDLASVQALLRKHEGLE 301
Q + + Q+ +RD +W+ +KE+ S L +++L++ H+
Sbjct: 2780 HVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2836
Query: 302 RDLAALEDKVKALCAEADRL---QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLN 358
+ L A + AE + L Q +A Q+Q+ + TNW+ ER +L
Sbjct: 2837 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT--IKTNWDTFNKQVKERENKLK 2894
Query: 359 DSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSF 417
+S + ++ L W+ + + + + D A E + + + + E+D H
Sbjct: 2895 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2954
Query: 418 KSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQ---CMD-LQLFY 473
+ + + +LL+ + V+++E +L++ ++ +Q C++ + +
Sbjct: 2955 ELLNNTANSLLSVCEIDKE-------VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3007
Query: 474 RDTEQVDNWMSKQEAFLLNE-DLGDSLDSVEALLKKH----EDFEKSLSAQEEKITALDE 528
++ ++V +Q + D+ DSL S +A K+ + +KSL A + ++
Sbjct: 3008 KEFQEVSKESKRQLQCAKEQLDIHDSLGS-QAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3066
Query: 529 FATKLI--QNNHYAMEDVATRRDALLSRRNALHERAMRR----RAQLADSFHLQQFFRDS 582
A L+ ++ DV + + + + L ++ + +L H Q R+
Sbjct: 3067 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3126
Query: 583 DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVN 642
+ ++++ + +D LQ + + +AF +L A + D K + ++
Sbjct: 3127 FSQFAEFDDELDSMAPVG-RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATE 3185
Query: 643 HYAKDEVAARMN-EVISLW-KKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEG 699
+ D V + + E +S KLL+ + + ++ ++ ++F +++ + L + E
Sbjct: 3186 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3245
Query: 700 HLASDD-YGKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQF--QDAGHFDAENI 755
H S G + + Q L + ++ Q + + + A + +
Sbjct: 3246 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3305
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-VEDEETWIREKEPIAASTNR-G 813
+ + + AR++ L + + R +L ++L F+D +E +W+ + E + A+
Sbjct: 3306 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS 3365
Query: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQK 871
+ V+ +++ + LQ + + ++ + ++G + A+ VK +L L+ +
Sbjct: 3366 AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSR 3424
Query: 872 WEALKAKASQRRQDLED-SLQAQQYFADANEAESWMREKEP-IVGSTDYGKDEDSAEALL 929
WEAL KA R + LE S+ AQQ+ W+ E +V G E +
Sbjct: 3425 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3484
Query: 930 KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMK 989
+H+AL D+ + + QA S Q + K++V + D+ + E+ K
Sbjct: 3485 AQHKALEDDIINHNKHLH----QAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3540
Query: 990 KGDILTLLNST-------NKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
LL +D W EV+D+ + KL Q S E L +
Sbjct: 3541 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK--------LSKLS-VQDYSTEGLWK 3591
Query: 1038 EQGS-------IALRQEQID----NQTRITKEAGS-----VSLRMKQVEELYHSLLELGE 1081
+Q I LR++ +D N + K+ + +++ ++ Y + +L
Sbjct: 3592 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3651
Query: 1082 KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV----GADLEQVEVLQKKFDDF 1136
LE++ + +E L W+++ E L S E G + Q ++ K +
Sbjct: 3652 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK---EL 3708
Query: 1137 QKDLKANESRLKDINK--------------------VAEDLESEGLMAEEV-QAVQQQEV 1175
+K+ K N++ L +N+ VAED E L+++ + Q V++ +
Sbjct: 3709 KKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDA 3768
Query: 1176 YGMMPRD-------------ETDSKTAS--------PWKSARLMV--------------- 1199
+ + ET+ K S SA+L V
Sbjct: 3769 AILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3828
Query: 1200 -------HTVATFNSIKELNERWRSLQQL-----------AEERSQLLGSAHEVQRFHRD 1241
H + T S +E + L ++ +E QL + V +F
Sbjct: 3829 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3888
Query: 1242 ADETKEWIEEKNQALNT-DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI 1300
+E W+ E ++ + +++ Q +H +A ++ + +T +L+
Sbjct: 3889 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3948
Query: 1301 QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRD--LMSWINGI 1358
+ P +QEK + +S + + +R L ++ D D L S +
Sbjct: 3949 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4008
Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
L ++ +V + + ++ +++ ++ +Q G++++A +I
Sbjct: 4009 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4068
Query: 1419 KL--DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN-WMAAREAFLNTEDKGD 1475
K D LDQ + W ++++ E +L E AE W + +D D
Sbjct: 4069 KAVQDKLDQ----MVFIWENIHTLVEE-REAKLLDV-MELAEKFWCDHMSLIVTIKDTQD 4122
Query: 1476 SLDSVE------ALIKKHEDFDKAIN-----VQEEKIAALQAFADQLIAAGHYAKGDISS 1524
+ +E +++K+ ++ + I +QEE + ++ + A G K +
Sbjct: 4123 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4182
Query: 1525 RRNEVLDRWRRLKAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS---EKLQTASDESYK 1580
+E+ W L ++ KL E+ Q Q+ + + W+ KL + S
Sbjct: 4183 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----- 4237
Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
P L + + ++ + F++E + + + L+++ + V+ L
Sbjct: 4238 -PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 4296
Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQN-FNTGIKDFDFWLSEVEALLASED-YGKDLASV 1698
L W L ++ + KL+ A F + + WL+ E LL+ + G D ++
Sbjct: 4297 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4356
Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGRFQKIKSM 1757
L KH +L+ D+ AH+ ++ +N + L+ SSA + S +++K + +N R+Q +
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4416
Query: 1758 AASRRAKLNESHRLHQFFR-DMDDEESWIK--EKKLLVGSEDYGRDLTGVQNLRKKHKRL 1814
R+ +L+ + R + F +++D + W+ E+ LL G T + L H +
Sbjct: 4417 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV-HMEV 4475
Query: 1815 EAELAAHEPAIQGVLDTGKK-LSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
A A E + ++ G++ L+ + I Q + E W+ ++ R +LEE
Sbjct: 4476 CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4535
Query: 1874 SLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931
+L +F ++++ W+ + + TL + L + + +H+ F + H++++
Sbjct: 4536 ALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQI 4595
Query: 1932 NDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWK 1989
++ G L + + I + + + + + + +R LD+ QF+
Sbjct: 4596 IELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEA 4655
Query: 1990 ADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT-----A 2043
+ W+ E E SL ++ + D ++T L + + F L A + + + T +
Sbjct: 4656 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA--KHSVYDTTNRTGRS 4713
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
LK++ A + ++ + L +W + S R+ KL EA + D
Sbjct: 4714 LKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL----- 4766
Query: 2104 KASAFNSWFENAEEDLTD--PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
A W E L + PV ++ + L + H AF+ L + L R+
Sbjct: 4767 --QALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4823
Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANA 2221
+ + + M+ L W + + ++ L+ R+ EE F +A
Sbjct: 4824 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEE-------FHSVVHA 4876
Query: 2222 FHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
+W+ E L + ++ L + ++ K +++ R++L K +G
Sbjct: 4877 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMG 4929
Score = 226 bits (576), Expect = 2e-58
Identities = 433/2280 (18%), Positives = 920/2280 (40%), Gaps = 246/2280 (10%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF-FQRDAEELEKWIQEKLQIASDENY- 72
+Q + + + F + R KL++S ++ E L WI + + +
Sbjct: 2868 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2927
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
DP + + K ++ + E+ + G + L+ T N ++S E + L ++ +
Sbjct: 2928 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2987
Query: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND-----KEAIVTSEELGQDL---EHV 184
++ E++ K L + + Q +E ++V KE + + LG +++
Sbjct: 2988 MVTEQLHSKKFCL---ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3044
Query: 185 EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL------IKTKQDEVNAAWQ 238
+LQ + Q + A + +V+ + A L+ E + ++T E + Q
Sbjct: 3045 TMLQTQ----QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3100
Query: 239 RLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ------- 291
++ + KL G Q R++ + ++ MA GRD ++Q
Sbjct: 3101 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP--VGRDAETLQKQKETIK 3158
Query: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR--EELITNWEQIRTL 349
A L+K E L A D C +++ P + +KR E L ++
Sbjct: 3159 AFLKKLEAL----MASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDR 3211
Query: 350 AAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEH-- 406
A R ++ + RL+ F + ++ + + + + E + G E Q +
Sbjct: 3212 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE----HEESQGPVGMETETINQQLNMF 3267
Query: 407 ----KGEIDAHEDSFKSADESGQALLAAGHYAS---------DEVREKLTVLSEERAALL 453
K EI+ + + + GQ L+ + ++ D+V + L+++ A
Sbjct: 3268 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA--- 3324
Query: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS-LDSVEALLKKHEDF 512
+ Q E + F E + +WM E + N+ + V+A +++ +
Sbjct: 3325 ---QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL 3381
Query: 513 EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-SRRNALHERAMRRRAQLAD 571
++ L ++ + + K+ A + ++ +LL SR AL +A R QL
Sbjct: 3382 QRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3441
Query: 572 -SFHLQQFFRDSDELKSWVN--EKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
S QQF + L W+ EK + S L+ ++ +H+A E ++ + +
Sbjct: 3442 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3501
Query: 629 DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV- 687
GQ L ++ ++ + +W +E E K E QQ N +
Sbjct: 3502 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW--YIEIQE-KSHSRSELLQQALCNAKIF 3558
Query: 688 --EDIEL--WLYEVEGHLAS---DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
+++EL WL EV L+ DY + + Q + +L+ D+ + +D +
Sbjct: 3559 GEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELRVLQEDILLRKQNVDQALLN 3616
Query: 741 ARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEE- 797
+ Q G + I+ K EA+ ARY+ + + + L +L+L + +E
Sbjct: 3617 GLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3675
Query: 798 TWIR--EKEPIAASTN--RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
TW+ E E ++ T +G++ Q K+ L+ E ++ + ++ + +A++E
Sbjct: 3676 TWLDKVEVELLSYETQVLKGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLEL 3732
Query: 854 GHFAA-EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE-SWMREKEP 911
+ A E ++ + E N+++ + +Q+ ++++ ++ Q F A +AE SW+ E E
Sbjct: 3733 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3792
Query: 912 ---IVGSTDYGKDEDSAEALLKK--------HEALMSDLSAYGSSIQAL--REQAQSCRQ 958
+G +D+ SA+ ++K H+ ++ DL G I E+ QS ++
Sbjct: 3793 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3852
Query: 959 QVAPTDDETGKELVLALYDY--QEKSPREVTMKKGDILTLLNSTNKDW--------WKVE 1008
++ + VL YD Q S R + +++ L N+ W W E
Sbjct: 3853 KL---------DKVLKNYDTICQINSERYLQLERAQSLV-----NQFWETYEELWPWLTE 3898
Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITK--------EAG 1060
+PA ++ Q L E IA + ID + E
Sbjct: 3899 TQSIISQLPAPALEYETLRQQQEEHRQLREL--IAEHKPHIDKMNKTGPQLLELSPGEGF 3956
Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVG 1120
S+ + + LY + E +KR L+++ + F + ++ Q + + E +
Sbjct: 3957 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILE------SLERIV 4008
Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQ---QQEVYG 1177
L Q + + + ++ + N++ D+ K+ E+ EE+ A +++
Sbjct: 4009 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4068
Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAE----ERSQLLGSAH 1233
+D+ D W++ +HT+ ++E + + +LAE + L+ +
Sbjct: 4069 KAVQDKLDQMVFI-WEN----IHTL-----VEEREAKLLDVMELAEKFWCDHMSLIVTIK 4118
Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
+ Q F RD ++ G D + V+ Q E ++ L ++++ +
Sbjct: 4119 DTQDFIRDLEDP----------------GIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4162
Query: 1294 ETAERLIQSHPESAEDLQEKCT-ELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
LI + E + + +K ELN AW SL K R KL ++ ++ + +
Sbjct: 4163 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4222
Query: 1352 MSWINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
W++ G L S + D+ + +E ++ ++E + + + LL
Sbjct: 4223 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4282
Query: 1411 YASPE--IKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAF 1467
S + ++ L L LE+ + R+ L+ L L F ++ W+ E
Sbjct: 4283 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4342
Query: 1468 LNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
L+ + G ++E + KH + + + A+ + LI + + +
Sbjct: 4343 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4402
Query: 1527 NEVLD-RWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEAWISE--------KLQTASD 1576
EVL+ RW+ + + +++ +L G + + F ++++++ W+++ K
Sbjct: 4403 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4462
Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS-EDAVK 1635
E+ K+ N+ H A A + + ++ G ++ R C S E +
Sbjct: 4463 ETAKEQLNV-----------HMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNID 4509
Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALL-ASEDYGK 1693
+ L ++W+ + K E+ KL+EA N F+ ++DF WL++ E L +
Sbjct: 4510 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSL 4569
Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQ 1752
L +V + +H++ ++++H +++ +L+ L S D +K+ ++ R++
Sbjct: 4570 ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWE 4629
Query: 1753 KIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTGVQNLRKK 1810
K+ R L+++ R QF W++E + + SE + D ++ +
Sbjct: 4630 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4689
Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ--QRLAQFVEHWKELKQLAAARG 1868
HK + L A TG+ L + ++ + ++ L++ + W + + R
Sbjct: 4690 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4749
Query: 1869 QRLEESLEYQ-QFVANVEEEEAWINEKMTLVASED--YGDTLAAIQGLLKKHEAFETDFT 1925
+LEE+L + QF ++ W+ +A + +GD + + L+ H+AF+ +
Sbjct: 4750 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELG 4808
Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ 1985
V + + ++LI+ + + +M+ L+ + + + ++ +L+ +A Q
Sbjct: 4809 KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLE--AALRQ 4866
Query: 1986 FNWKADVVES---WIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
VV + W+ E E +L+ D +++TL+ + + F L+ + E +
Sbjct: 4867 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAE-LNKA 4925
Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMK-RWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
T + D +LA H S ++++ R+ ++LA + +++L A + ++L
Sbjct: 4926 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL-- 4983
Query: 2101 FAKKASAFNSWFENAEEDLTDP---VRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
A +W + AE LTD V +EE+KAL H F ++ Q D +++ +
Sbjct: 4984 -----EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5038
Score = 188 bits (477), Expect = 6e-47
Identities = 502/2586 (19%), Positives = 1010/2586 (39%), Gaps = 326/2586 (12%)
Query: 14 DIQERRQ---QVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEEL-EKWIQEKLQIAS 68
++ E+RQ + D + K +S + + E F + + A++L E+W +QI
Sbjct: 1250 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI-- 1307
Query: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
D +D L+G + + + I +++ T + S+T+ T+L
Sbjct: 1308 DNRLRD---LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---- 1360
Query: 129 RQWELLLEKMREKGIKLLQAQKLV-QYLRECEDVMDWINDKEAIVTSEELG-----QDLE 182
Q ++L+ ++ K K+ + QK QY +D A+V S++ +
Sbjct: 1361 NQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQS 1420
Query: 183 HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE-LIKTKQDEVNAAWQRLK 241
+++ ++F + +T A + + +FA ++ EE+ L + K++ V A + K
Sbjct: 1421 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1480
Query: 242 GLA-LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH--- 297
++ + + K A F++ + +KEQL + L ++Q L KH
Sbjct: 1481 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEA------LQTIQLFLAKHGDK 1534
Query: 298 ------EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
LE+ + L++ L +E+ + Q S T VK EE I A
Sbjct: 1535 MTDEERNELEKQVKTLQESYNLLFSESLKQLQE---SQTSGDVKVEEKIV---------A 1582
Query: 352 ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
ER Q + + + +T+ + + + A + L ++Q + E+
Sbjct: 1583 ERQ---------QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1633
Query: 412 AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
K S QAL + ++E LS+E AL+E + + +C L L
Sbjct: 1634 ------KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKIKCEQLNL 1685
Query: 472 FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
EQ SK+E LD V K E + + Q E+ E
Sbjct: 1686 ---KAEQ-----SKKE-----------LDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1726
Query: 532 KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
+ N E T+ ++ + N H + ++ + + + ++D + V
Sbjct: 1727 DWLSNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGEEDEVNGNLLETD-VDGQVGT 1784
Query: 592 KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA 651
+ + K + + + +HQA + A QS LEK GQ L + K+++
Sbjct: 1785 TQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYL---SPEEKEKLQK 1838
Query: 652 RMNEVISLWKKLLEATELKGIKLREANQQQ--QFNRNVEDIELWLYEVEGHLASDDYGKD 709
M E+ ++ L +E K +KL + Q++ +F+ + + E WL + E L + + G D
Sbjct: 1839 NMKELKVHYETALAESEKK-MKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1897
Query: 710 -LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF---------QDAGHFDAE----NI 755
+ + K+ DV +H+ + ITI + +D G D +
Sbjct: 1898 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1957
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED---------EETWIRE-KEP 805
++K + R+ +L L D + Q + D E T + EP
Sbjct: 1958 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2017
Query: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGHF--AAEDVK 862
IA D +Q L++ +ALQ +I+ + ++ + + +++ G A D++
Sbjct: 2018 IAV------DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2071
Query: 863 AKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA-NEAESWMREKEPIVGSTDYGKD 921
L ++ ++E L ++R + L+ +L D +E WM E +
Sbjct: 2072 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2131
Query: 922 EDSA-EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
+A + ++ K+ L D++ SSI A+ E+ + + TD T L + D
Sbjct: 2132 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET---TDPSTASSLQAKMKDLSA 2188
Query: 981 KSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG 1040
+ E + K + L + KVE+ + +KL + L E
Sbjct: 2189 RFS-EASHKHKETLAKMEELKT---KVELFENLS-------EKLQTFLETKTQALTE--- 2234
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE------LGEKRKGMLEKSCKKF 1094
+ + + + ++ +E+ S L K+ E+ HSLL+ L + +LEK+
Sbjct: 2235 -VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNN-- 2291
Query: 1095 MLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK------ 1148
L ++ E++ I EK+ A+TS + L+ +VL K + K+ ++
Sbjct: 2292 -LSKKFKEMEDTIKEKKEAVTSCQ--EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2348
Query: 1149 DINKVAEDL----ESEGLMAEEVQAVQQQEVY--GMMPRDETDSKTASPWKSARLMVHTV 1202
D+ K ED E L E+Q V + ++ T +K + KS +++
Sbjct: 2349 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2408
Query: 1203 ATFNSIKEL--NERWRSLQQ---------------LAEERSQLLGSAHEVQRFHRDADET 1245
T + +E N+ S+++ L ++ ++L ++Q+ ++
Sbjct: 2409 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2468
Query: 1246 KEWIEEKNQALNTDNYGH---DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
+W+++ N+ D +V+ +++ FE +L +KV L + L++
Sbjct: 2469 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2528
Query: 1303 HPESAEDLQEK--CTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIR 1359
+P++ E + K TE++ W L + R+ KL +S ++L +F + L W+
Sbjct: 2529 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2588
Query: 1360 GLVSS-DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
+VS L+ D ++ Q E R ++ GQ +L+ P ++
Sbjct: 2589 LMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG-EDPSLR- 2646
Query: 1419 KLDILDQERADLEKAWVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK--GD 1475
I+ ++ A + + W L D+C + Q ++ + + L+ D
Sbjct: 2647 --GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2704
Query: 1476 SL------DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAA--GHYAKGDISSRRN 1527
SL D++ ++ + + I ++++I QA + L A Y K ++S +
Sbjct: 2705 SLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLE 2764
Query: 1528 EVLDRWRRLKAQ----MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
+L ++ ++ + + +S S QQ SRD +AW+ K + +++ P
Sbjct: 2765 GILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD---FQAWLDTKKE---EQNKSHPI 2818
Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA-VKARLAALA 1642
+ +L L S + H+ F L A + I G +L+ + GSE A ++ +L +
Sbjct: 2819 SAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEKAALQLQLNTIK 2876
Query: 1643 DQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
W ++ E+ KLKE+ K + ++ W+ + + L + D A N
Sbjct: 2877 TNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENS 2936
Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
+ K + L+ ++ H ++ LN+ A+SL++ D V D+ ++ + + S+
Sbjct: 2937 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2996
Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG-RDLTGVQNLRKKHKRLEAELAA 1820
+ L + + F+++ E +++L E D G Q K+ +
Sbjct: 2997 KFCLENMTQKFKEFQEVSKES----KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK 3052
Query: 1821 HEPAIQGVLDTGKKLSDDNTI------GKEEIQQRLAQFVEHWKELKQLAAARGQRLEES 1874
A++ +D K+L+ D + G ++ ++ + L Q + LE
Sbjct: 3053 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3112
Query: 1875 LE----YQQFVANVEEEEAWINEKMTLVA-----SEDYGDTLAAIQGLLKKHEAFETDFT 1925
L+ +Q + + + A ++++ +A +E I+ LKK EA
Sbjct: 3113 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS-- 3170
Query: 1926 VHKDRVNDVCT-------NGQDLI----------KKNNHHEENISSKMKGLNGKVSDLEK 1968
D N C DL+ K+ N + ++ + + G + LE+
Sbjct: 3171 --NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE 3228
Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
+ KL E S LQ KA+ E G ++T+ + L+ + + K+E
Sbjct: 3229 FYS----KLKEFSILLQ---KAEEHEESQGPV--GMETETINQQLNMFK-VFQKEEI--E 3276
Query: 2029 GLQAFQQEGIANITALKDQLL--AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE 2086
LQ QQ+ + L L+ AAK ++ +E + RW L A R +L E
Sbjct: 3277 PLQGKQQD----VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3332
Query: 2087 AQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP--------VRCNSLEEIKALREAH 2138
A H + +D + SW + EE + + V ++E K L+
Sbjct: 3333 ALLHCGRFQDAL-------ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLL 3385
Query: 2139 DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELEL 2198
D +S++ + + ++A ++ + L+ W L + R +L
Sbjct: 3386 DDRKSTVEVIKREGEKIATTAEPADKVKILKQ------LSLLDSRWEALLNKAETRNRQL 3439
Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
E + Q+F + ++W+ L++ + ++ LE Q+ K
Sbjct: 3440 -------EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3492
Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQW-DQLDQLGMRMQHNLEQQI 2317
+I L + +G +++ ++K S + +Q W ++ + L+Q +
Sbjct: 3493 DIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQAL 3552
Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEF--------KSCLRSLGYDLPMVEE 2369
G E L M + + DK +L+ Q++ +S LR L D+ + ++
Sbjct: 3553 CNAKIFGEDEVEL----MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3608
Query: 2370 GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAF-RALSSEGKPY 2428
+ D + +Q+ + + +R + K S ++ +AL + +
Sbjct: 3609 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3668
Query: 2429 VTKEEL 2434
T EEL
Sbjct: 3669 STHEEL 3674
Score = 167 bits (423), Expect = 1e-40
Identities = 206/996 (20%), Positives = 441/996 (44%), Gaps = 77/996 (7%)
Query: 1 MDPSGVKVLETAE----DIQERRQQVLDRYHRFKELSTLRRQKLED--SYRFQFFQRDAE 54
M+ +G ++LE + IQE+ Y + KE R L++ S QF + +
Sbjct: 3940 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3999
Query: 55 ELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD----------E 104
LE E++ E + P ++ +++K + ++ N V ++ +
Sbjct: 4000 ILESL--ERIV----ERLRQPPSISAEVEK---IKEQISENKNVSVDMEKLQPLYETLKQ 4050
Query: 105 TGNLMISEG-----HFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ------ 153
G MI+ +++ ++ +L ++ WE + + E+ KLL +L +
Sbjct: 4051 RGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4110
Query: 154 --YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
+ +D D+I D E + G D V+ Q+ E + ++ +E ++ V
Sbjct: 4111 MSLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4164
Query: 212 AAKLIQE-QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETIS 269
++LI P++ ++K DE+N+AW L R KL A + ++ +
Sbjct: 4165 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4224
Query: 270 WIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLS 328
W+ +AS G DL +V+ + + + + + + +++ L +A+ L +
Sbjct: 4225 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4284
Query: 329 ATQ--IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALIN 385
+ + +Q EL W+ + R +L + L +F +L +W+T + L++
Sbjct: 4285 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4344
Query: 386 ADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASDEVREKL 442
+ + D E L +H + ++ AH+ + ++ +++G L+ +AG AS+ ++ KL
Sbjct: 4345 EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN-LQNKL 4403
Query: 443 TVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLL-NEDLGDSLD 500
VL++ +LE E R+QQ + + + F+ + E + W++ E LL ++ LG +
Sbjct: 4404 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4463
Query: 501 SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAME-DVATRRDALLSRRNALH 559
+ + L H + + A+EE +L + +++ + E ++ + L + ++
Sbjct: 4464 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4523
Query: 560 ERAMRRRAQLADSFHLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQG----KVQKH 614
+ R+ +L ++ +L F +S + +W+ + +T PS + ++ +H
Sbjct: 4524 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN--VASRPSLILDTVLFQIDEH 4581
Query: 615 QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISL---WKKLLEATELKG 671
+ F E+++++ +I L+K G L + K +V N +IS+ W+K+++ +G
Sbjct: 4582 KVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERG 4639
Query: 672 IKLREANQQ-QQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNLQKKHALLEADVAA 729
L +A ++ +QF+ + WL E E L S+ + D ++ +H + + A
Sbjct: 4640 RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA 4699
Query: 730 HQDRIDGITIQARQFQDAGHFDAENIKKKQ--EALVARYEALKEPMVARKQKLADSLRLQ 787
D R ++ +N+K L +++ + V R+ KL ++L
Sbjct: 4700 KHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4759
Query: 788 QLFRD-VEDEETWIREKEP-IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
F D ++ W+ EP +A D+ V NL+ H+A Q E+ ++A+ +
Sbjct: 4760 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4819
Query: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAES 904
++E + VK ++ EL+ +WE + A + ++ LE +L QA+++ + +
Sbjct: 4820 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4879
Query: 905 WMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDL 939
W+ E E + DED+ L+ +H+ M L
Sbjct: 4880 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL 4915
Score = 160 bits (405), Expect = 1e-38
Identities = 484/2522 (19%), Positives = 976/2522 (38%), Gaps = 424/2522 (16%)
Query: 9 LETAEDIQERRQQVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA 67
++ E Q + Q+ ++ K L+T L +QK+ S + Q +E +K+ ++
Sbjct: 1335 IQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVS-EIEMKQSKMDECQKYAEQYSATV 1391
Query: 68 SDENYKDPTN--LQGKLQKHQAFEAEVQANSGAIV--------KLDETGNLMISEGHFAS 117
D + T + QK +Q+++ I+ + LM FA
Sbjct: 1392 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1451
Query: 118 ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLV----QYLRECEDV------MDWIND 167
++++ L + + L E+ +E K + QK V + L++ E I+
Sbjct: 1452 DSLK----RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1507
Query: 168 KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE---------ERVNEVNQFAAKLIQE 218
+E E+L + L+ +++ K + TD +E E N + + K +QE
Sbjct: 1508 EEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1567
Query: 219 QHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
EE+++ +Q E Q + L Q + +L G E E +
Sbjct: 1568 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1627
Query: 273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
++E+L D G A + + L+ + L + KAL + +L ++ + Q+
Sbjct: 1628 KQEELQ-KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ--KLNEAK-IKCEQL 1683
Query: 333 QVKREELITNWEQIRTLAA-ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELAS 391
+K E+ +++ T A E ++ +L+ +L W++ N D+ S
Sbjct: 1684 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DS 1736
Query: 392 DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
+ AG + HK I+ + F+ D G++ + DEV L + ++
Sbjct: 1737 ERAGTK--------HKQVIEQNGTHFQEGD--GKSAIGE----EDEVNGNL-LETDVDGQ 1781
Query: 452 LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
+ E QQY++ Q + +S+ +A ++ + S + LL+K
Sbjct: 1782 VGTTQENLNQQYQKVK---------AQHEKIISQHQAVII------ATQSAQVLLEKQGQ 1826
Query: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
+ LS +E++ KL +N M+++ + L+ E+ M+ L +
Sbjct: 1827 Y---LSPEEKE---------KLQKN----MKELKVHYETALAES----EKKMKLTHSLQE 1866
Query: 572 SFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSN-LQGKVQKHQAFEAELSANQSRID 629
L++F D E + W+ + + + EA D N L K+++ ++F ++ +++ +
Sbjct: 1867 E--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1924
Query: 630 ALEKAGQKLIDVNHYAKD-------------EVAARMNEVISLWKKLLEATELKGIKLRE 676
+ +G ++++ EV +++ ++ L + G L++
Sbjct: 1925 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1984
Query: 677 ANQQQQFNRNVE-----DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+ Q + ++ HL S+ D N+Q ++ L+ +++ Q
Sbjct: 1985 LVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQ 2043
Query: 732 DRIDGITIQARQFQDA--GHFDAEN-IKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
++ + A DA A+N I+K + +V RYE L + + R +KL +L
Sbjct: 2044 VAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2103
Query: 789 LFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
+D DE E+ ++E+ + ++ +Q+++ K+ L+ +IAG + I
Sbjct: 2104 SVQDGLDEMLDWMGNVESSLKEQGQVPLNST------ALQDIISKNIMLEQDIAGRQSSI 2157
Query: 841 KAVTQKGNAMVEEGH-FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA 899
A+ +K +E A ++AK+ +L+ ++ K + +E+ + F +
Sbjct: 2158 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 2217
Query: 900 NEA-ESWMREKEPIVGSTDY-GKD---------EDSAEALL-KKH----EALMSDLSAYG 943
+E ++++ K + D GKD E ++E L KKH +L+ ++S++G
Sbjct: 2218 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 2277
Query: 944 -----------------------SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
+I+ +E SC++Q+ + + LV +L + +
Sbjct: 2278 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL-----DAFQVLVKSLKSWIK 2332
Query: 981 KSPREVTMKKG-----DILTLLNSTNK--DWWKVEVNDRQ-----GFVPAAYVKKLD-PA 1027
++ ++V + + D+ L T K + W ++ + Q G + + PA
Sbjct: 2333 ETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPA 2392
Query: 1028 QSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGML 1087
++ + ++ G++ + N G S++ K + ++ H +LG K +
Sbjct: 2393 KAIAA---VKSGGAVLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI 2448
Query: 1088 EKSCKKFMLFREANE----LQQWINEKEAALTSEE---VGADLEQVEVLQKKFDDFQKDL 1140
+ K ++A E + QW+ + T + D E V+ ++ F+ +L
Sbjct: 2449 AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2508
Query: 1141 KANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
K N ++++++ +K+ E LE + D+ A WK
Sbjct: 2509 KQNVNKVQELKDKLTELLE-----------------------ENPDTPEAPRWKQM---- 2541
Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIEEKN----- 1253
+ E++ +W+ L QL +R Q L S++ + +F + K+W+ EK
Sbjct: 2542 --------LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2593
Query: 1254 --------QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPE 1305
LNT + + RK + +E+ AA ++ GE P
Sbjct: 2594 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQ-YEQLTAAGQGILSRPGED--------PS 2644
Query: 1306 SAEDLQEKCTELNQAWSSL----GKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
++E+ + Q W SL R D + S Q L D +S ++ L
Sbjct: 2645 LRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KL 2702
Query: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQL--LAHGHYASPEIKQK 1419
SS ++ LE Q+ + EI + + + L L Y E+ ++
Sbjct: 2703 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2762
Query: 1420 LDILDQERADLE-KAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK-GDSL 1477
L+ + + D+E KA + + C F + + W+ ++ N L
Sbjct: 2763 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2822
Query: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA-KGDISSRRNEVLDRWRRL 1536
D +E+LIK H+DF K + Q A + L+ + K + + N + W
Sbjct: 2823 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2882
Query: 1537 KAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS------EKLQTASDESYKDPTNIQLSK 1589
Q+ E+ +KL ES + ++ V+ + WI E+++ D + + + +L
Sbjct: 2883 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2942
Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLI--ERGACAGSEDAVKARLAALADQWQF 1647
L + +H L+ A+ + V ++ ++ E + D V +L + +
Sbjct: 2943 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3002
Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQ 1706
+ QK E + KE+ +Q D + L S+ Y K L + K Q
Sbjct: 3003 MTQKFKEFQEVSKESKRQLQCAKEQLD-------IHDSLGSQAYSNKYLTMLQTQQKSLQ 3055
Query: 1707 LLEADISAHEDRLKDLNSQA-DSLMTSSA-FDTSQVKDKRDTINGRFQKIKSMAASRRAK 1764
L+ + + +DL +A DS TS + + T++ Q++ + K
Sbjct: 3056 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS---QQVDEKCSFLETK 3112
Query: 1765 L-------NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ----NLRKKHKR 1813
L N + F + DDE L GRD +Q ++ K+
Sbjct: 3113 LQGIGHFQNTIREMFSQFAEFDDE---------LDSMAPVGRDAETLQKQKETIKAFLKK 3163
Query: 1814 LEAELAAHEPAIQGVLDTGKKL--SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1871
LEA +A+++ A + T K + +++ + I++ L + +L A AR +++
Sbjct: 3164 LEALMASNDNANK----TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3219
Query: 1872 EESLE-YQQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQGLLKKHEAFE-TDFTVHK 1928
E +++ ++F + ++E + + S+ G I L + F+ + +
Sbjct: 3220 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3279
Query: 1929 DRVNDVCTNGQDLIKK--NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
+ DV GQ LI+ + + + + +N + L K AQR A+L E A L
Sbjct: 3280 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE--ALLHC 3337
Query: 1987 NWKADVVE---SWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT 2042
D +E SW+ + E + + V+ + +Q+ LQ + + +
Sbjct: 3338 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL----LQRLLDDRKSTVE 3393
Query: 2043 ALK---DQLLAAKHVQSKAIEARHASLM-KRWSQLLANSAARKKKL----LEAQSHFRKV 2094
+K +++ K + SL+ RW LL + R ++L + AQ +
Sbjct: 3394 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3453
Query: 2095 EDL--FLTFAKKA---------------------SAFNSWFENAEEDLTDPVRCNSLEEI 2131
E L +LT +K A N + L V ++
Sbjct: 3454 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3513
Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
+ RE D +S L DF+Q+ ++ Q KS E L++ N KI
Sbjct: 3514 LSSREDKDMVQSKL-----DFSQVWYIEIQEKSHS---------RSELLQQALCN-AKIF 3558
Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT------ 2245
E E+EL E +DKL + Q + W Q++ +L ++ +
Sbjct: 3559 GEDEVELM--NWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3616
Query: 2246 ---------------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEH 2290
++ +LEA K ++++I + + D+ +E+AL L + H
Sbjct: 3617 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST------DVAKTLEQALQLARRL--H 3668
Query: 2291 ST 2292
ST
Sbjct: 3669 ST 3670
Score = 112 bits (281), Expect = 3e-24
Identities = 330/1819 (18%), Positives = 696/1819 (38%), Gaps = 265/1819 (14%)
Query: 669 LKGIKLREANQQQQFNRN-VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
LK L + +++ N V+D+ W+ E++ L ++G DL +V++ + H + +
Sbjct: 618 LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 677
Query: 728 AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
+ + I Q +K L ++Y L +++ L L
Sbjct: 678 EEFESSLKEAKISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQERHLDT---LH 731
Query: 788 QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
+E W+ EKE + + + + H L E+ E IK+V +
Sbjct: 732 NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIA 791
Query: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
++ E H A ++A + +W + Q ++++ ++F DA EA ++R
Sbjct: 792 EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 851
Query: 908 EKEPIVG---STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
+ + S D E L+++ +L Y S+I L +A++ Q
Sbjct: 852 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 911
Query: 965 DETGKEL--VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV 1021
D K + A+ DY++ E+T+ K D L N++++ WKV + VP+
Sbjct: 912 DCPLKTSIPIKAICDYRQ---IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCF 968
Query: 1022 KKLDPAQSA-SRENLLEE--QGSIALRQEQIDNQTRIT------------KEAGSVSLRM 1066
P + A N +E+ Q + L E N + + + S++
Sbjct: 969 TVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKT 1028
Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKK--------FMLFREANELQQWINEKEAALTSEE 1118
E L L + + LE S + L +E N +Q+ E + EE
Sbjct: 1029 MLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREE 1088
Query: 1119 ------------------------------VGADLEQVEVLQKKFD-DFQKDLKANESRL 1147
+ LE+ ++ + F Q+ LK RL
Sbjct: 1089 QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL 1148
Query: 1148 KD----INKVAEDLESEGLMAEEVQAVQQQ---------EVYGM----MPRDETDSKTAS 1190
KD I E+ S+ + V ++ + +VY M + + +T +
Sbjct: 1149 KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 1208
Query: 1191 PWKSARLMVH-----------TVATFNSIKEL---NERWRS--------LQQLAEERSQL 1228
++A +V +A N+I+ L ++WRS L +E +
Sbjct: 1209 NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 1268
Query: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
+ E+ + +++ D +W +EK L + + + + R EG + L D
Sbjct: 1269 KAISDEMFKTYKERDLDFDWHKEKADQL-VERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1327
Query: 1289 VNSLG------ETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD- 1340
+ L ET +R IQ + PE+++ L T+LNQ L + +++K+ +
Sbjct: 1328 YHPLDDWIQQVETTQRKIQENQPENSKTL---ATQLNQQ-KMLVSEIEMKQSKMDECQKY 1383
Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELA-----KDVTGAEALLERHQEHRTEIDARAGTF 1395
+++ + +D R +V S + + + + A+ +++ + RT A
Sbjct: 1384 AEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1443
Query: 1396 QAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF----- 1450
+ +F A +K+ L++E LE+ +++ +++ ELQ +
Sbjct: 1444 TQYIKF----------AGDSLKR----LEEEEKSLEE---EKKEHVEKAKELQKWVSNIS 1486
Query: 1451 --HRDCEQA------ENWMAAREAFLNTEDKGDSLDSVEALIKKHED--FDKAINVQEEK 1500
+D E+A + +++ E E ++L +++ + KH D D+ N E++
Sbjct: 1487 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1546
Query: 1501 IAALQAFADQLIAAG------HYAKGDISSRRNEVLDRWRRLKAQ-------MIEKRSKL 1547
+ LQ + L + GD+ V +R + K + + + ++L
Sbjct: 1547 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1606
Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASD---------ESYKDPTNI---------QLSK 1589
Q E++ + S++ + D E K+ N Q K
Sbjct: 1607 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1666
Query: 1590 LLSKHQKHQAFE--AELHANADRIRGVIDMG-----NSLIERGACAGSEDAVKARLAALA 1642
L + + ++A +L+ A++ + +D E+ A + K ++ L
Sbjct: 1667 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1726
Query: 1643 DQWQFLVQKSAEKS-QKLKEANKQQNFNTGIKDFDFWLSEVEA----LLASEDYGKDLAS 1697
D W V K +E++ K K+ +Q + D + E + LL ++ G+ +
Sbjct: 1727 D-WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1785
Query: 1698 VNNLLKKHQLLEAD----ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
NL +++Q ++A IS H+ + S L + + + K+K N + K
Sbjct: 1786 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK-NMKELK 1844
Query: 1754 IKSMAA----SRRAKLNES--HRLHQFFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQN 1806
+ A ++ KL S L +F D + E W+++ + + + + G D+ G+
Sbjct: 1845 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 1904
Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSD-------------DNTIGKEEIQQRLAQF 1853
K+ K ++ +H+ ++ + +G ++ + D + E+Q++L
Sbjct: 1905 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 1964
Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQF-------VANVEEEEAWINEKMTLVASEDYGD 1905
+ ++ L G L++ ++ YQ + +A ++ EA ++ + SE
Sbjct: 1965 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL----SEPIAV 2020
Query: 1906 TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH---HEENISSKMKGLNGK 1962
+Q L++ +A + + + V + + L+ + +I + + G+
Sbjct: 2021 DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR 2080
Query: 1963 VSDLEKAAAQRKAKLDEN-SAFLQFNWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLL 2020
DL K+ +R KL + L D + W+G E+SLK + +++Q ++
Sbjct: 2081 YEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDII 2140
Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
+K + + Q ++I A+ +++ + + + MK S + ++ +
Sbjct: 2141 SKNIMLEQDIAGRQ----SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2196
Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
K+ L + +LF ++K F A ++ P + ++ L +
Sbjct: 2197 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGK-----DVTELSQYMQE 2251
Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQK 2200
S + L L ++I S + S+ LE+T NL K KE E +++
Sbjct: 2252 STSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL-----VLEKT-NNLSKKFKEMEDTIKE 2305
Query: 2201 EQRRQEENDKLRQEFAQHANAFHQWIQET--RTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
++ + F + WI+ET + ++ S E+ G LE TK+ +
Sbjct: 2306 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLEDTKKLQE 2362
Query: 2259 EIRAMRSQLKKIEDLGAAM 2277
+ +++K+ + G ++
Sbjct: 2363 KWSLKTPEIQKVNNSGISL 2381
Score = 102 bits (255), Expect = 4e-21
Identities = 450/2452 (18%), Positives = 904/2452 (36%), Gaps = 352/2452 (14%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ--IASDENYKDPTNLQGKLQKHQA 87
K L+T R Q+ F R EL W+ EK + +A D + ++ TN+ K H
Sbjct: 715 KLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEEEVAYDWSERN-TNIARKKDYHAE 772
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQ 147
E+ I + E ++ E H A TI + QW +L+
Sbjct: 773 LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ----------L 822
Query: 148 AQKLVQYLRECEDVMDWIND-KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
Q + Q+++E ++ ND KEA L + +Q+K+ +R +
Sbjct: 823 CQCVEQHIKENTAYFEFFNDAKEATDYLRNL------KDAIQRKYS---------CDRSS 867
Query: 207 EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK---LFGAAEVQRF--N 261
+++ + + +EEL++ K N + + L+ + L + ++
Sbjct: 868 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 927
Query: 262 RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL 321
R ++ TI K+ E ++A++ + E V ++C
Sbjct: 928 RQIEITI--YKDDECVLANNSHRAKWKVISP------------TGNEAMVPSVCFTVPPP 973
Query: 322 QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF-RDLTSWVTEM 380
+ A +I+ + + ++T W E H + + + R S V +
Sbjct: 974 NKEAVDLANRIEQQYQNVLTLWH-------ESHINMKSVVSWHYLINEIDRIRASNVASI 1026
Query: 381 KALINADE---LASDVAGAEALLDRHQEHK----GEIDAHEDSFKSADESGQALLAAGHY 433
K ++ + L++ + E L+ QE + +I E + Q LL +
Sbjct: 1027 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1086
Query: 434 ASDEVREKLTVLSEERAALLELWELRRQQYEQCM------DL-QLFYRDTEQVDNWMSKQ 486
E +SE R L L + Q DL + +R TEQ K+
Sbjct: 1087 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE---KLKK 1143
Query: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
E L +DLG + K E+F S +A + L ++QN + +T
Sbjct: 1144 ELERLKDDLG-------TITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 1195
Query: 547 RRDAL----LSRRNALHERAM---------RRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
D L L +N A+ A +AD +++ + +S V+EK
Sbjct: 1196 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1255
Query: 594 K---TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKL-IDVNHYAKD-- 647
+ DE K + + ++ + + ++ + D L + Q + + +++ +D
Sbjct: 1256 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1315
Query: 648 ------EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHL 701
+ + W + +E T+ K I+ + + + ++ + E+E
Sbjct: 1316 GIGKSLKYYRDTYHPLDDWIQQVETTQRK-IQENQPENSKTLATQLNQQKMLVSEIEMKQ 1374
Query: 702 AS-DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQE 760
+ D+ K K + L A D ++ R+ Q + A+ I ++
Sbjct: 1375 SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS----ADLIIQEFM 1430
Query: 761 ALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGV 819
L RY AL M + DSL RL++ + +E+E +KE + + K + +
Sbjct: 1431 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-----KKEHVEKAKELQKWVSNI 1485
Query: 820 QNLLKKHQALQAEIAGHEP--RIKAVTQKGNAMVEEGHFAAEDVKAKL------------ 865
LK AE AG P + K +++ + E+ A + ++ L
Sbjct: 1486 SKTLK-----DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1540
Query: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE-----KEPIVGSTDYGK 920
+EL ++ + L+ + + LQ Q D E + E KE + G D
Sbjct: 1541 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLT 1600
Query: 921 DEDSAEALLKKHEALM-----SDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLAL 975
++ L+ EA M +L Y S + L++ Q Q +A E K L
Sbjct: 1601 QTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA----EVVKNTENFL 1654
Query: 976 YDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035
+ EK +E K I LN ++ + Q K+LD + + +
Sbjct: 1655 KENGEKLSQE---DKALIEQKLNEAKIKCEQLNLKAEQS------KKELDKVVTTA---I 1702
Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
EE +A ++ +++T+I +S K E G K K ++E++ F
Sbjct: 1703 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE-------RAGTKHKQVIEQNGTHF- 1754
Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK-DINKVA 1154
Q + K A +EV +L + +V + Q++L ++K K+
Sbjct: 1755 ---------QEGDGKSAIGEEDEVNGNLLETDV-DGQVGTTQENLNQQYQKVKAQHEKII 1804
Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
++ + + Q + +++ + P ++ + ++KEL
Sbjct: 1805 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ------------------KNMKELKVH 1846
Query: 1215 WRSLQQLAEERSQLLGS-AHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQ 1272
+ + +E++ +L S E+++F D E + W+++ Q L N + D+ +
Sbjct: 1847 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1906
Query: 1273 RKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE-------------DLQEKCTELNQ 1319
++ + F D+ + + + + R++++ ++ ++Q K
Sbjct: 1907 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1966
Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVS---SDELAKDVTGAE 1375
+ SL + + L D D + D L++ + S S+ +A D +
Sbjct: 1967 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2026
Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLL-AHGHY--ASPEIKQKLDILDQERADLEK 1432
LE + + +I ++ + ++ + LL A G A +I++ LD + DL K
Sbjct: 2027 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2086
Query: 1433 AWVQRRMMLDQCLELQLFHRD-CEQAENWMAAREAFLNTE-----DKGDSLDSVEALIKK 1486
+ +R L L L +D ++ +WM E+ L + + D + I
Sbjct: 2087 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2146
Query: 1487 HEDF---DKAINVQEEKIAALQAFADQLIAAGHYAK-GDISSRRNEVLDRWRRLKAQMIE 1542
+D +IN EK+ D A+ AK D+S+R +E + + A+M E
Sbjct: 2147 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2206
Query: 1543 KRSKLGESQTLQQFSRDVDEIEAWISEKLQ--TASDESYKDPTNIQ--LSKLLSKHQKHQ 1598
++K ++ F ++++ ++ K Q T D KD T + + + S+ +H+
Sbjct: 2207 LKTK------VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2260
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
LH+ I + V + L+ +++ + EK +
Sbjct: 2261 KHLEVLHSLLKE-----------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 2309
Query: 1659 LKEANKQQN-FNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLLKKHQLLEA 1710
+ +Q + F +K W+ E V+ +ED GK L L +K L
Sbjct: 2310 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2369
Query: 1711 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTING--------RFQKIKSMAASRR 1762
+I + L S +T+ A + VK +NG F K + + ++
Sbjct: 2370 EIQKVNNSGISL-CNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2428
Query: 1763 AKLNESHRLHQFFRDMDDEESWIKEK--KLLVGSEDYGRDLTGVQNLRK----------- 1809
+ SH + D+ + + K KL E+ + +Q + K
Sbjct: 2429 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2488
Query: 1810 -----------KHKRLEAELAAHEPAIQGVLDTGKKLSDDN--TIGKEEIQQRLAQFVEH 1856
++K EAEL + +Q + D +L ++N T +Q L +
Sbjct: 2489 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2548
Query: 1857 WKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL- 1914
W+EL QL R Q+LEES QF + + W+ EK +V+ L+ +L
Sbjct: 2549 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS---VLGPLSIDPNMLN 2605
Query: 1915 ---KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE----------NISSKMKGLNG 1961
++ + +F K + + GQ ++ + ++ K L G
Sbjct: 2606 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2665
Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
++SD Q K + + L + S K D LSS + T
Sbjct: 2666 QLSDRCDWIDQAIVKSTQYQSLL---------------RSLSDKLSDLDNKLSSSLAVST 2710
Query: 2022 KQETFDAGLQAFQQEGIANITALKDQLLAAKHV---QSKAIEARH--ASLMKRWSQLLAN 2076
+ + L+ Q+ I K Q+ A+ + S ++ + A L ++ +L +
Sbjct: 2711 HPDAMNQQLETAQKMK-QEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2769
Query: 2077 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE--NAEEDLTDPVRCNSLEEIKAL 2134
++K H + F + + F +W + E++ + P+ L+ +++L
Sbjct: 2770 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA-KLDVLESL 2828
Query: 2135 REAHDAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
+ H F +L++ + + +AE + + + + + ++ W K +KE
Sbjct: 2829 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2888
Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLD-GSCMVEESGTLESQLEA 2252
RE +L +E+ + ++ + WI + + L + C+ G E+ +
Sbjct: 2889 RENKL-------KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG--ENSIAK 2939
Query: 2253 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQ 2304
K +E+ ++ + + ++ +D + L Q+ D + +
Sbjct: 2940 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 2991
Score = 70.1 bits (170), Expect = 3e-11
Identities = 87/439 (19%), Positives = 179/439 (40%), Gaps = 52/439 (11%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIASDENY 72
+ + ++ D++ S R+ KLE++ F DA + L W+ + Q+A D+
Sbjct: 4727 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4786
Query: 73 KDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
+L + H+AF+ E+ + ++ L + +I S ++ ++ EL +W
Sbjct: 4787 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4846
Query: 132 ELLLEKMREKGIKLLQAQKLVQYLRECED-------VMDWINDKEAIVTSEE-LGQDLEH 183
E + + + + +L LR+ E+ +++W+ + E + L D +
Sbjct: 4847 ETVC------ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4900
Query: 184 VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEE-ELIKTKQDEVNAAWQRLKG 242
+ L + +EF + +N+ ++ HP+ IK + A ++ +
Sbjct: 4901 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4960
Query: 243 LALQRQGKLFGAAEVQRFNRDVDETI-SWIKEKEQLMASDD---FGRDLASVQALLRKHE 298
A Q Q +L A +++ E + +W++ E + D +++ V+AL+ +H+
Sbjct: 4961 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5020
Query: 299 GLERDLAALE---DKV----KALCAEADRLQQSHPL--------------------SATQ 331
++ + DKV K A+ LQ P+ S TQ
Sbjct: 5021 TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQ 5080
Query: 332 IQVKREE---LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
I+ K L++ W+Q+ LA ER +LND+ L +F + + K + +
Sbjct: 5081 IETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNH 5140
Query: 389 LASDVAGAEALLDRHQEHK 407
S V +D+ Q+ K
Sbjct: 5141 KKSRVMDFFRRIDKDQDGK 5159
Score = 60.1 bits (144), Expect = 3e-08
Identities = 64/276 (23%), Positives = 114/276 (41%), Gaps = 12/276 (4%)
Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
+DL +WV EM+ ++ E SD+ E+ L+ H+ I+ E S K A S + A
Sbjct: 638 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 697
Query: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
EKL L + A LL R Q L F W++++E
Sbjct: 698 ---LKLTYAEKLHRLESQYAKLL---NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 751
Query: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
+ D + ++ H + + L +EE I ++ E A +L+ NH A + R A
Sbjct: 752 VAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 811
Query: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK-DPSN--- 606
+ ++ + + + + ++ +FF D+ E ++ +K A Y D S+
Sbjct: 812 MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL-RNLKDAIQRKYSCDRSSSIH 870
Query: 607 -LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDV 641
L+ VQ+ + EL +S I L + +I +
Sbjct: 871 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 906
Score = 57.0 bits (136), Expect = 2e-07
Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 22/279 (7%)
Query: 145 LLQAQKLVQYLRECE-------DVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTD 197
LL++ L Q L E E D+++W+++ + + E G DL VE E +
Sbjct: 617 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE---SHLENHKNV 673
Query: 198 MAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 257
A EE + + + IQ P + K + + + +L + ++ L +
Sbjct: 674 HRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTL 730
Query: 258 QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAE 317
F + W+ EKE+ + D+ ++ H L R+L E+ +K++
Sbjct: 731 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 790
Query: 318 ADR-LQQSHPLSATQIQVKREELITNWEQIRTL--AAERHARLNDSYRLQRFLADFRDLT 374
A++ L ++HP T I+ R + T W I L E+H + N +Y F D ++ T
Sbjct: 791 AEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQCVEQHIKENTAY--FEFFNDAKEAT 847
Query: 375 SWVTEMKALIN---ADELASDVAGAEALLDRHQEHKGEI 410
++ +K I + + +S + E L+ E K E+
Sbjct: 848 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 886
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 278 bits (711), Expect = 5e-74
Identities = 415/1966 (21%), Positives = 824/1966 (41%), Gaps = 178/1966 (9%)
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASET--IRTRLMELHRQ 130
+D LQ + + +AF +++A + ++T +M++ + + I+ L L +Q
Sbjct: 3156 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 3215
Query: 131 WELLLEKM--REKGIK--LLQAQKLVQYLRECEDVMDWINDKEAI-----VTSEELGQDL 181
LL++ RE+ ++ + + ++ L+E ++ + E + +E + Q L
Sbjct: 3216 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 3275
Query: 182 EHVEVLQKKFEEFQTDMAAHEERVNEVNQ----FAAKLIQEQHPEEELIKTKQDEVNAAW 237
+V QK EE + + ++ VN + Q AAK Q E +L D+VNA W
Sbjct: 3276 NMFKVFQK--EEIEP-LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL-----DDVNARW 3327
Query: 238 QRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLR 295
+ L QR +L A RF ++ +SW+ + E+L+A+ + V+A ++
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3387
Query: 296 KHEGLERDLAALEDKVKALCAEADRLQQS-HPLSATQIQVKREELITNWEQIRTLAAERH 354
+ + L+R L + V+ + E +++ + P +I + L + WE + A R+
Sbjct: 3388 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3447
Query: 355 ARLND-SYRLQRFLADFRDLTSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDA 412
+L S Q+F L W+T + K L+N + + + + E + +H+ + +I
Sbjct: 3448 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3507
Query: 413 HEDSFKSADESGQAL-LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-DLQ 470
H A GQ+L + + D V+ KL + E R + +Q + + +
Sbjct: 3508 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3567
Query: 471 LFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLSAQEEKITAL 526
+F D ++ NW+++ L + D S E L K+ + E L ++ AL
Sbjct: 3568 IFGEDEVELMNWLNEVHDKLSKLSVQDY--STEGLWKQQSELRVLQEDILLRKQNVDQAL 3625
Query: 527 DEFATKLIQNNHYAMEDVATRRDALLSRRNALHE------RAMRRRAQLADSFHLQQFFR 580
L Q + + + +A+ +R + + + + + QLA H
Sbjct: 3626 LNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTH--- 3682
Query: 581 DSDELKSWVNE---KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
+EL +W+++ ++ + + K Q +++ + + E N++ +D+L +
Sbjct: 3683 --EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNEVSSA 3739
Query: 638 LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN--QQQQFNRNVEDIELWLY 695
L+++ + E +M + +L+ T + ++ +A + QQF++ + W+
Sbjct: 3740 LLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT 3799
Query: 696 EVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA-GHFD 751
E E L S +D T+ Q +K +E + H+D ID + + A +
Sbjct: 3800 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHKIMTACSEEE 3857
Query: 752 AENIKKKQEALVARYEALKEPMVARKQKL--ADSLRLQQLFRDVEDEETWIREKEPIAAS 809
+++KKK + ++ Y+ + + R +L A SL + Q + E+ W+ E + I +
Sbjct: 3858 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETYEELWPWLTETQSIISQ 3916
Query: 810 TNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
+ ++ ++H+ L+ IA H+P I + + G ++E ++ K
Sbjct: 3917 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA 3976
Query: 869 NQKWEALKAKASQRRQDLEDSLQAQQYFADANEA--ESWMREKEPIVGSTDYGKDEDSAE 926
+ + +K +R L++++ F D + ES R E + + + +
Sbjct: 3977 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4036
Query: 927 ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ----EKS 982
+ +++ + D+ + L+++ + + TD + + V D E
Sbjct: 4037 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4096
Query: 983 PREVTMKKGDILTLLNSTNKDWWK-----VEVNDRQGFVPAAYVKKLDPA----QSASRE 1033
V ++ +L ++ K W V + D Q F+ +DP+ Q + E
Sbjct: 4097 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156
Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVS------LRMKQVEEL---YHSLLELGEKRK 1084
+ EE + QE++D + E + + K ++EL + SL + + R
Sbjct: 4157 TIREEIDGL---QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4213
Query: 1085 GMLEKSCKKFMLFREANE-LQQWINEKEAALTS-EEVGADLEQVEVLQKKFDDFQKDLKA 1142
LE++ + + +++ + + W++ L S +G DLE V+ ++ F+ +
Sbjct: 4214 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4273
Query: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
+ ++ +N AE L+ ++V +E+D HTV
Sbjct: 4274 QQIEMERLNHQAE------LLLKKVT-------------EESDK-------------HTV 4301
Query: 1203 ATFNSIKELNERWRSLQQ-LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN- 1260
+ + EL W SL++ + + +L G+ + +F DE W+ L+
Sbjct: 4302 Q--DPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4359
Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTELNQ 1319
G D +++ KH + D+ A V ++ + LI+S E A +LQ K LNQ
Sbjct: 4360 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4419
Query: 1320 AWSSLGKRADQRKAKL-GDSHDLQRFLSDFRDLMSWINGI-RGLVSSDELAKDVTGAEAL 1377
W ++ ++ +QRK +L G + F + DL W+ R L++S L A+
Sbjct: 4420 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4479
Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQ 1436
L H E +A+ T+++ Q GQQ+LA A I Q ++ L ++ +E +
Sbjct: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539
Query: 1437 RRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAI 1494
R+ L++ L L + FH + NW+ E LN + LD+V I +H+ F +
Sbjct: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599
Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRN---EVLDRWRRLKAQMIEKRSKLGESQ 1551
N E+I L L K D+ +N V RW ++ +++E+ L +++
Sbjct: 4600 NSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4657
Query: 1552 T-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
+QF ++ W+ SEK + E DP I+ L++H++ Q H+
Sbjct: 4658 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ--LAQHKEFQKSLGAKHSVY 4715
Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK-QQN 1667
D G SL E+ + A + L+ L D+W + KS E+ KL+EA
Sbjct: 4716 DTTNRT---GRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4772
Query: 1668 FNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
F ++ WL VE LA + +G D+ V NL+ H+ + ++ ++ L
Sbjct: 4773 FTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4831
Query: 1726 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR--------LHQFFRD 1777
A L+ S D+S VK + ++ R++ + +++ S++ +L + R +H
Sbjct: 4832 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4891
Query: 1778 MDDEESWIKEKKLLVGSEDYGRDLTGV-QNLRKKHKRLEAELAAHEPAIQGVL-----DT 1831
+ + E ++ +L ED R L + KK + AEL VL D+
Sbjct: 4892 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 4951
Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA---ARGQRLEESLEYQQFVANVEEEE 1888
+ TI + ++ LA +H + L A A+ + LE L + Q
Sbjct: 4952 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQ--------- 5002
Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
W +T E + ++ L+ +H+ F + T + V+ V
Sbjct: 5003 -WAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5047
Score = 265 bits (676), Expect = 5e-70
Identities = 503/2529 (19%), Positives = 1024/2529 (40%), Gaps = 298/2529 (11%)
Query: 49 FQRDAEELEKWIQEKLQIASDENYKDPTN-----LQGKLQKHQAFEAEVQANSGAIVK-L 102
FQ+ + + + W+ K + ++N P + L+ ++ H+ F + A S K +
Sbjct: 2805 FQQMSRDFQAWLDTKKE---EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2861
Query: 103 DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA-QKLVQYLRECEDV 161
E NL++ ++ +L + W+ ++++E+ KL ++ +K ++Y + E +
Sbjct: 2862 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2921
Query: 162 MDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
WI+ + + + D E K + Q +M H V +N A L+
Sbjct: 2922 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2981
Query: 222 EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE-----KEQ 276
++E++ DE + Q++ + Q K F + + ++ E K KEQ
Sbjct: 2982 DKEVVT---DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQ 3038
Query: 277 LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
L D G S L + ++ L AL+ +V A RL Q + A+ +
Sbjct: 3039 LDIHDSLGSQAYS-NKYLTMLQTQQKSLQALKHQVDL----AKRLAQDLVVEASDSKGTS 3093
Query: 337 EELITNWEQIRTLAAERHARLNDSY---------RLQ---RFLADFRDLTSWVTEMKALI 384
+ L+ Q+ T+A E H+ L+ +LQ F R++ S E +
Sbjct: 3094 DVLL----QVETIAQE-HSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDEL 3148
Query: 385 NADELASDVAGAEALLDRHQEHKG---EIDAHEDSFKSADESGQALLAAGHYASDEV--R 439
D +A AE L + + K +++A S +A+++ + +LA + D V +
Sbjct: 3149 --DSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3206
Query: 440 EKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDTEQVDNWMSKQEAFLLNED-LGD 497
L LS++ LL+ + R +Q E + L+ FY ++ + K E ++ +G
Sbjct: 3207 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 3266
Query: 498 SLDSVEALLKKHEDFEKS----LSAQEEKITALDEFATKLIQNNHYAMEDVATRR----- 548
+++ L + F+K L +++ + L + LIQ+ A + +T+
Sbjct: 3267 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ---GLIQS---AAKSTSTQGLEHDL 3320
Query: 549 DALLSRRNALHERAMRRRAQLADSF-HLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN- 606
D + +R L+++ +R AQL ++ H +F + L SW+ + + ++ K PS
Sbjct: 3321 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ--KPPSAE 3378
Query: 607 ---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA-KDEVAARMNEVISLWKK 662
++ ++Q+ + + L +S ++ +++ G+K+ A K ++ +++ + S W+
Sbjct: 3379 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3438
Query: 663 LLEATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLAS-DDYGKDLTNVQNLQKKH 720
LL E + +L + QQF+ +E + WL +E L + + G + ++ +H
Sbjct: 3439 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3498
Query: 721 ALLEADVAAHQDRI-DGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
LE D+ H + ++I + D + ++ K + Y ++E +R +
Sbjct: 3499 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3558
Query: 780 LADSLRLQQLFRDVEDE-ETWIRE-KEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHE 837
L +L ++F + E E W+ E + ++ + + G+ + + LQ +I +
Sbjct: 3559 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3618
Query: 838 PRIKAVTQKGNAMVEEGHFAAEDV---KAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQ 893
+ G ++++ ++V + KL + +++ + ++ + LE +LQ A+
Sbjct: 3619 QNVDQALLNGLELLKQT--TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3676
Query: 894 QYFADANEAESWMR--EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
+ + E +W+ E E + T K E++++A ++ E L + + + +L E
Sbjct: 3677 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNE 3735
Query: 952 QAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVND 1011
S ++ P G E ++A + + L++ T KVE D
Sbjct: 3736 -VSSALLELVPWRAREGLEKMVA--------------EDNERYRLVSDTITQ--KVEEID 3778
Query: 1012 RQGFVPAAYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITK------------ 1057
+ + D S E L G I L Q+Q Q ++ K
Sbjct: 3779 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3838
Query: 1058 ------------------EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
E S+ ++ +V + Y ++ ++ +R LE++ F E
Sbjct: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3898
Query: 1100 A-NELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL 1157
EL W+ E ++ ++ A + E + Q++ ++ + ++ + +NK L
Sbjct: 3899 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3958
Query: 1158 ----ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNE 1213
EG +E + V +Y + D + VA +I + +
Sbjct: 3959 LELSPGEGFSIQE-KYVAADTLYSQIKED--------------VKKRAVALDEAISQSTQ 4003
Query: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
+ Q+ E +++ + + ++ KE I E N D+ +Q L
Sbjct: 4004 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK------NVSVDMEKLQPLYE 4057
Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
L G+++ + ++ I SA+ +Q+K ++ W ++ ++R+A
Sbjct: 4058 T-------LKQRGEEMIARSGGTDKDI-----SAKAVQDKLDQMVFIWENIHTLVEEREA 4105
Query: 1334 KLGDSHDL-QRFLSDFRDLMSWINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDAR 1391
KL D +L ++F D L+ I + + ++ D + + E + R EID
Sbjct: 4106 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 4165
Query: 1392 AGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
G +L+A G P +K+ +D L+ L KAW R L++ ++ +
Sbjct: 4166 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 4225
Query: 1451 HRDCEQAE-NWM-AAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508
++D QA +W+ A + G L++V+ I++ + F Q+ ++ L A
Sbjct: 4226 YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQA 4285
Query: 1509 DQLI--AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEA 1565
+ L+ K + E+ W L+ ++I ++ KL G L QF +DE+ A
Sbjct: 4286 ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 4345
Query: 1566 WIS--EKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1623
W++ E L + DP I++ KH + ++ A+ + V GN LIE
Sbjct: 4346 WLTHTEGLLSEQKPVGGDPKAIEIELA-----KHHVLQNDVLAHQSTVEAVNKAGNDLIE 4400
Query: 1624 RGACAGSEDA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSE 1681
+ AG E + ++ +L L +WQ +++K+ ++ Q+L A +Q + F+ I+D WL++
Sbjct: 4401 --SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4458
Query: 1682 VEA-LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDT-SQ 1739
E LLAS+ G + L H + A A E+ K L + ++ +
Sbjct: 4459 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4518
Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLH-QFFRDMDDEESWIK--EKKLLVGSED 1796
+ + + +++ +++ R+ KL E+ L +F + D +W+ E+ L V S
Sbjct: 4519 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4578
Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE---IQQRLAQF 1853
L V +HK E+ +H I + TG L + K++ I+ L
Sbjct: 4579 -SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISV 4635
Query: 1854 VEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQ 1911
W+++ Q RG+ L+++ + +QF + W+ E + SE + + I+
Sbjct: 4636 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4695
Query: 1912 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENIS--SKMKGLNGKVSDLEKA 1969
L +H+ F+ + G+ L +K + ++N+ + L K +
Sbjct: 4696 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4755
Query: 1970 AAQRKAKLDENSAFL-QFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTKQETF 2026
+ +R+ KL+E F QF + W+ E L D +G D+ V L+ + F
Sbjct: 4756 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAF 4814
Query: 2027 DAGLQAFQQEGIANITALKD---QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKK 2083
L + +++ ALK +L+ S ++ + L RW + A S +++ +
Sbjct: 4815 QKELG----KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4870
Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLT-DPVRCNSLEEIKALREAHDAFR 2142
L ++ R+ E+ F A W AE+ L V + + ++ L + H F
Sbjct: 4871 L---EAALRQAEE----FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4923
Query: 2143 SSLSSAQADFNQLAELDRQIKSFRVASNPYT---WFTM------EALEETWRNLQK---- 2189
L +A+ N+ + + + + T W T+ E L ++ Q+
Sbjct: 4924 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4983
Query: 2190 ----IIKERELELQKEQRRQEEN---DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEE 2242
I K+ LE + E DK ++ Q I E +T++ + M +
Sbjct: 4984 LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEE---MTRK 5040
Query: 2243 SGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVG-------- 2294
++ + KR+ + +++S + + D G A + + Y S
Sbjct: 5041 QPDVDKVTKTYKRRAADPSSLQSHIPVL-DKGRAGRKRFPASSLYPSGSQTQIETKNPRV 5099
Query: 2295 --LAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM---------------- 2336
L +W Q+ L + + L + E L+EF+
Sbjct: 5100 NLLVSKWQQVWLLALERRRKLNDALDRL-------EELREFANFDFDIWRKKYMRWMNHK 5152
Query: 2337 -------FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2389
F+ DKD+ G++ QEF + S + + E A+ D D + DG
Sbjct: 5153 KSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL-------EMSAVADIFDRDGDG 5205
Query: 2390 HVSLQEYMA 2398
++ E++A
Sbjct: 5206 YIDYYEFVA 5214
Score = 233 bits (594), Expect = 2e-60
Identities = 446/2453 (18%), Positives = 976/2453 (39%), Gaps = 266/2453 (10%)
Query: 21 QVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIAS--DENYKDPTN 77
++ ++ +L+ R+QKLE+S FQ +L++W+ EK + S DP
Sbjct: 2555 EIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2614
Query: 78 LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTRLMELHRQWELL 134
L + Q+ Q E +L G ++S E ++ +L + ++W+ L
Sbjct: 2615 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2674
Query: 135 LEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSEE-LGQDLEHVE 185
++ ++ +K Q Q L++ L + D+ + ++ A+ T + + Q LE +
Sbjct: 2675 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2734
Query: 186 VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNA---AWQRLKG 242
++++ ++ + + + +++ L++E++ + EL + + + + Q+ +
Sbjct: 2735 KMKQEIQQEKKQIKVAQALCEDLSA----LVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2790
Query: 243 LALQRQGKLFGAAEVQRFNRDVDETISWIK-EKEQLMASDDFGRDLASVQALLRKHEGLE 301
Q + + Q+ +RD +W+ +KE+ S L +++L++ H+
Sbjct: 2791 HVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2847
Query: 302 RDLAALEDKVKALCAEADRL---QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLN 358
+ L A + AE + L Q +A Q+Q+ + TNW+ ER +L
Sbjct: 2848 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT--IKTNWDTFNKQVKERENKLK 2905
Query: 359 DSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSF 417
+S + ++ L W+ + + + + D A E + + + + E+D H
Sbjct: 2906 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2965
Query: 418 KSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQ---CMD-LQLFY 473
+ + + +LL+ + V+++E +L++ ++ +Q C++ + +
Sbjct: 2966 ELLNNTANSLLSVCEIDKE-------VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3018
Query: 474 RDTEQVDNWMSKQEAFLLNE-DLGDSLDSVEALLKKH----EDFEKSLSAQEEKITALDE 528
++ ++V +Q + D+ DSL S +A K+ + +KSL A + ++
Sbjct: 3019 KEFQEVSKESKRQLQCAKEQLDIHDSLGS-QAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3077
Query: 529 FATKLI--QNNHYAMEDVATRRDALLSRRNALHERAMRR----RAQLADSFHLQQFFRDS 582
A L+ ++ DV + + + + L ++ + +L H Q R+
Sbjct: 3078 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3137
Query: 583 DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVN 642
+ ++++ + +D LQ + + +AF +L A + D K + ++
Sbjct: 3138 FSQFAEFDDELDSMAPVG-RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATE 3196
Query: 643 HYAKDEVAARMN-EVISLW-KKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEG 699
+ D V + + E +S KLL+ + + ++ ++ ++F +++ + L + E
Sbjct: 3197 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3256
Query: 700 HLASDD-YGKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQF--QDAGHFDAENI 755
H S G + + Q L + ++ Q + + + A + +
Sbjct: 3257 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-VEDEETWIREKEPIAASTNR-G 813
+ + + AR++ L + + R +L ++L F+D +E +W+ + E + A+
Sbjct: 3317 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS 3376
Query: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQK 871
+ V+ +++ + LQ + + ++ + ++G + A+ VK +L L+ +
Sbjct: 3377 AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSR 3435
Query: 872 WEALKAKASQRRQDLED-SLQAQQYFADANEAESWMREKEP-IVGSTDYGKDEDSAEALL 929
WEAL KA R + LE S+ AQQ+ W+ E +V G E +
Sbjct: 3436 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3495
Query: 930 KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMK 989
+H+AL D+ + + QA S Q + K++V + D+ + E+ K
Sbjct: 3496 AQHKALEDDIINHNKHLH----QAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3551
Query: 990 KGDILTLLNST-------NKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
LL +D W EV+D+ + KL Q S E L +
Sbjct: 3552 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK--------LSKLS-VQDYSTEGLWK 3602
Query: 1038 EQGS-------IALRQEQID----NQTRITKEAGS-----VSLRMKQVEELYHSLLELGE 1081
+Q I LR++ +D N + K+ + +++ ++ Y + +L
Sbjct: 3603 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3662
Query: 1082 KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV----GADLEQVEVLQKKFDDF 1136
LE++ + +E L W+++ E L S E G + Q ++ K +
Sbjct: 3663 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK---EL 3719
Query: 1137 QKDLKANESRLKDINK--------------------VAEDLESEGLMAEEV-QAVQQQEV 1175
+K+ K N++ L +N+ VAED E L+++ + Q V++ +
Sbjct: 3720 KKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDA 3779
Query: 1176 YGMMPRD-------------ETDSKTAS--------PWKSARLMV--------------- 1199
+ + ET+ K S SA+L V
Sbjct: 3780 AILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3839
Query: 1200 -------HTVATFNSIKELNERWRSLQQL-----------AEERSQLLGSAHEVQRFHRD 1241
H + T S +E + L ++ +E QL + V +F
Sbjct: 3840 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3899
Query: 1242 ADETKEWIEEKNQALNT-DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI 1300
+E W+ E ++ + +++ Q +H +A ++ + +T +L+
Sbjct: 3900 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3959
Query: 1301 QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRD--LMSWINGI 1358
+ P +QEK + +S + + +R L ++ D D L S +
Sbjct: 3960 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4019
Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
L ++ +V + + ++ +++ ++ +Q G++++A +I
Sbjct: 4020 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4079
Query: 1419 KL--DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN-WMAAREAFLNTEDKGD 1475
K D LDQ + W ++++ E +L E AE W + +D D
Sbjct: 4080 KAVQDKLDQ----MVFIWENIHTLVEE-REAKLLDV-MELAEKFWCDHMSLIVTIKDTQD 4133
Query: 1476 SLDSVE------ALIKKHEDFDKAIN-----VQEEKIAALQAFADQLIAAGHYAKGDISS 1524
+ +E +++K+ ++ + I +QEE + ++ + A G K +
Sbjct: 4134 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4193
Query: 1525 RRNEVLDRWRRLKAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS---EKLQTASDESYK 1580
+E+ W L ++ KL E+ Q Q+ + + W+ KL + S
Sbjct: 4194 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----- 4248
Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
P L + + ++ + F++E + + + L+++ + V+ L
Sbjct: 4249 -PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 4307
Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQN-FNTGIKDFDFWLSEVEALLASED-YGKDLASV 1698
L W L ++ + KL+ A F + + WL+ E LL+ + G D ++
Sbjct: 4308 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGRFQKIKSM 1757
L KH +L+ D+ AH+ ++ +N + L+ SSA + S +++K + +N R+Q +
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427
Query: 1758 AASRRAKLNESHRLHQFFR-DMDDEESWIK--EKKLLVGSEDYGRDLTGVQNLRKKHKRL 1814
R+ +L+ + R + F +++D + W+ E+ LL G T + L H +
Sbjct: 4428 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV-HMEV 4486
Query: 1815 EAELAAHEPAIQGVLDTGKK-LSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
A A E + ++ G++ L+ + I Q + E W+ ++ R +LEE
Sbjct: 4487 CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4546
Query: 1874 SLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931
+L +F ++++ W+ + + TL + L + + +H+ F + H++++
Sbjct: 4547 ALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQI 4606
Query: 1932 NDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWK 1989
++ G L + + I + + + + + + +R LD+ QF+
Sbjct: 4607 IELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEA 4666
Query: 1990 ADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT-----A 2043
+ W+ E E SL ++ + D ++T L + + F L A + + + T +
Sbjct: 4667 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA--KHSVYDTTNRTGRS 4724
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
LK++ A + ++ + L +W + S R+ KL EA + D
Sbjct: 4725 LKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL----- 4777
Query: 2104 KASAFNSWFENAEEDLTD--PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
A W E L + PV ++ + L + H AF+ L + L R+
Sbjct: 4778 --QALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANA 2221
+ + + M+ L W + + ++ L+ R+ EE F +A
Sbjct: 4835 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEE-------FHSVVHA 4887
Query: 2222 FHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
+W+ E L + ++ L + ++ K +++ R++L K +G
Sbjct: 4888 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMG 4940
Score = 226 bits (576), Expect = 2e-58
Identities = 433/2280 (18%), Positives = 920/2280 (40%), Gaps = 246/2280 (10%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF-FQRDAEELEKWIQEKLQIASDENY- 72
+Q + + + F + R KL++S ++ E L WI + + +
Sbjct: 2879 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2938
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
DP + + K ++ + E+ + G + L+ T N ++S E + L ++ +
Sbjct: 2939 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2998
Query: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND-----KEAIVTSEELGQDL---EHV 184
++ E++ K L + + Q +E ++V KE + + LG +++
Sbjct: 2999 MVTEQLHSKKFCL---ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3055
Query: 185 EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL------IKTKQDEVNAAWQ 238
+LQ + Q + A + +V+ + A L+ E + ++T E + Q
Sbjct: 3056 TMLQTQ----QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3111
Query: 239 RLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ------- 291
++ + KL G Q R++ + ++ MA GRD ++Q
Sbjct: 3112 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP--VGRDAETLQKQKETIK 3169
Query: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR--EELITNWEQIRTL 349
A L+K E L A D C +++ P + +KR E L ++
Sbjct: 3170 AFLKKLEAL----MASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDR 3222
Query: 350 AAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEH-- 406
A R ++ + RL+ F + ++ + + + + E + G E Q +
Sbjct: 3223 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE----HEESQGPVGMETETINQQLNMF 3278
Query: 407 ----KGEIDAHEDSFKSADESGQALLAAGHYAS---------DEVREKLTVLSEERAALL 453
K EI+ + + + GQ L+ + ++ D+V + L+++ A
Sbjct: 3279 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA--- 3335
Query: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS-LDSVEALLKKHEDF 512
+ Q E + F E + +WM E + N+ + V+A +++ +
Sbjct: 3336 ---QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL 3392
Query: 513 EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-SRRNALHERAMRRRAQLAD 571
++ L ++ + + K+ A + ++ +LL SR AL +A R QL
Sbjct: 3393 QRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3452
Query: 572 -SFHLQQFFRDSDELKSWVN--EKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
S QQF + L W+ EK + S L+ ++ +H+A E ++ + +
Sbjct: 3453 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3512
Query: 629 DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV- 687
GQ L ++ ++ + +W +E E K E QQ N +
Sbjct: 3513 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW--YIEIQE-KSHSRSELLQQALCNAKIF 3569
Query: 688 --EDIEL--WLYEVEGHLAS---DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
+++EL WL EV L+ DY + + Q + +L+ D+ + +D +
Sbjct: 3570 GEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELRVLQEDILLRKQNVDQALLN 3627
Query: 741 ARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEE- 797
+ Q G + I+ K EA+ ARY+ + + + L +L+L + +E
Sbjct: 3628 GLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3686
Query: 798 TWIR--EKEPIAASTN--RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
TW+ E E ++ T +G++ Q K+ L+ E ++ + ++ + +A++E
Sbjct: 3687 TWLDKVEVELLSYETQVLKGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLEL 3743
Query: 854 GHFAA-EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE-SWMREKEP 911
+ A E ++ + E N+++ + +Q+ ++++ ++ Q F A +AE SW+ E E
Sbjct: 3744 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3803
Query: 912 ---IVGSTDYGKDEDSAEALLKK--------HEALMSDLSAYGSSIQAL--REQAQSCRQ 958
+G +D+ SA+ ++K H+ ++ DL G I E+ QS ++
Sbjct: 3804 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3863
Query: 959 QVAPTDDETGKELVLALYDY--QEKSPREVTMKKGDILTLLNSTNKDW--------WKVE 1008
++ + VL YD Q S R + +++ L N+ W W E
Sbjct: 3864 KL---------DKVLKNYDTICQINSERYLQLERAQSLV-----NQFWETYEELWPWLTE 3909
Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITK--------EAG 1060
+PA ++ Q L E IA + ID + E
Sbjct: 3910 TQSIISQLPAPALEYETLRQQQEEHRQLREL--IAEHKPHIDKMNKTGPQLLELSPGEGF 3967
Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVG 1120
S+ + + LY + E +KR L+++ + F + ++ Q + + E +
Sbjct: 3968 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILE------SLERIV 4019
Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQ---QQEVYG 1177
L Q + + + ++ + N++ D+ K+ E+ EE+ A +++
Sbjct: 4020 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4079
Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAE----ERSQLLGSAH 1233
+D+ D W++ +HT+ ++E + + +LAE + L+ +
Sbjct: 4080 KAVQDKLDQMVFI-WEN----IHTL-----VEEREAKLLDVMELAEKFWCDHMSLIVTIK 4129
Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
+ Q F RD ++ G D + V+ Q E ++ L ++++ +
Sbjct: 4130 DTQDFIRDLEDP----------------GIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4173
Query: 1294 ETAERLIQSHPESAEDLQEKCT-ELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
LI + E + + +K ELN AW SL K R KL ++ ++ + +
Sbjct: 4174 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4233
Query: 1352 MSWINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
W++ G L S + D+ + +E ++ ++E + + + LL
Sbjct: 4234 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4293
Query: 1411 YASPE--IKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAF 1467
S + ++ L L LE+ + R+ L+ L L F ++ W+ E
Sbjct: 4294 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4353
Query: 1468 LNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
L+ + G ++E + KH + + + A+ + LI + + +
Sbjct: 4354 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4413
Query: 1527 NEVLD-RWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEAWISE--------KLQTASD 1576
EVL+ RW+ + + +++ +L G + + F ++++++ W+++ K
Sbjct: 4414 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4473
Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS-EDAVK 1635
E+ K+ N+ H A A + + ++ G ++ R C S E +
Sbjct: 4474 ETAKEQLNV-----------HMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNID 4520
Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALL-ASEDYGK 1693
+ L ++W+ + K E+ KL+EA N F+ ++DF WL++ E L +
Sbjct: 4521 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSL 4580
Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQ 1752
L +V + +H++ ++++H +++ +L+ L S D +K+ ++ R++
Sbjct: 4581 ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWE 4640
Query: 1753 KIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTGVQNLRKK 1810
K+ R L+++ R QF W++E + + SE + D ++ +
Sbjct: 4641 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4700
Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ--QRLAQFVEHWKELKQLAAARG 1868
HK + L A TG+ L + ++ + ++ L++ + W + + R
Sbjct: 4701 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4760
Query: 1869 QRLEESLEYQ-QFVANVEEEEAWINEKMTLVASED--YGDTLAAIQGLLKKHEAFETDFT 1925
+LEE+L + QF ++ W+ +A + +GD + + L+ H+AF+ +
Sbjct: 4761 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELG 4819
Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ 1985
V + + ++LI+ + + +M+ L+ + + + ++ +L+ +A Q
Sbjct: 4820 KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLE--AALRQ 4877
Query: 1986 FNWKADVVES---WIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
VV + W+ E E +L+ D +++TL+ + + F L+ + E +
Sbjct: 4878 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAE-LNKA 4936
Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMK-RWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
T + D +LA H S ++++ R+ ++LA + +++L A + ++L
Sbjct: 4937 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL-- 4994
Query: 2101 FAKKASAFNSWFENAEEDLTDP---VRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
A +W + AE LTD V +EE+KAL H F ++ Q D +++ +
Sbjct: 4995 -----EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5049
Score = 188 bits (477), Expect = 6e-47
Identities = 502/2586 (19%), Positives = 1010/2586 (39%), Gaps = 326/2586 (12%)
Query: 14 DIQERRQ---QVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEEL-EKWIQEKLQIAS 68
++ E+RQ + D + K +S + + E F + + A++L E+W +QI
Sbjct: 1261 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI-- 1318
Query: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
D +D L+G + + + I +++ T + S+T+ T+L
Sbjct: 1319 DNRLRD---LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---- 1371
Query: 129 RQWELLLEKMREKGIKLLQAQKLV-QYLRECEDVMDWINDKEAIVTSEELG-----QDLE 182
Q ++L+ ++ K K+ + QK QY +D A+V S++ +
Sbjct: 1372 NQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQS 1431
Query: 183 HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE-LIKTKQDEVNAAWQRLK 241
+++ ++F + +T A + + +FA ++ EE+ L + K++ V A + K
Sbjct: 1432 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1491
Query: 242 GLA-LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH--- 297
++ + + K A F++ + +KEQL + L ++Q L KH
Sbjct: 1492 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEA------LQTIQLFLAKHGDK 1545
Query: 298 ------EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
LE+ + L++ L +E+ + Q S T VK EE I A
Sbjct: 1546 MTDEERNELEKQVKTLQESYNLLFSESLKQLQE---SQTSGDVKVEEKIV---------A 1593
Query: 352 ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
ER Q + + + +T+ + + + A + L ++Q + E+
Sbjct: 1594 ERQ---------QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1644
Query: 412 AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
K S QAL + ++E LS+E AL+E + + +C L L
Sbjct: 1645 ------KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKIKCEQLNL 1696
Query: 472 FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
EQ SK+E LD V K E + + Q E+ E
Sbjct: 1697 ---KAEQ-----SKKE-----------LDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1737
Query: 532 KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
+ N E T+ ++ + N H + ++ + + + ++D + V
Sbjct: 1738 DWLSNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGEEDEVNGNLLETD-VDGQVGT 1795
Query: 592 KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA 651
+ + K + + + +HQA + A QS LEK GQ L + K+++
Sbjct: 1796 TQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYL---SPEEKEKLQK 1849
Query: 652 RMNEVISLWKKLLEATELKGIKLREANQQQ--QFNRNVEDIELWLYEVEGHLASDDYGKD 709
M E+ ++ L +E K +KL + Q++ +F+ + + E WL + E L + + G D
Sbjct: 1850 NMKELKVHYETALAESEKK-MKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1908
Query: 710 -LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF---------QDAGHFDAE----NI 755
+ + K+ DV +H+ + ITI + +D G D +
Sbjct: 1909 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1968
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED---------EETWIRE-KEP 805
++K + R+ +L L D + Q + D E T + EP
Sbjct: 1969 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2028
Query: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGHF--AAEDVK 862
IA D +Q L++ +ALQ +I+ + ++ + + +++ G A D++
Sbjct: 2029 IAV------DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2082
Query: 863 AKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA-NEAESWMREKEPIVGSTDYGKD 921
L ++ ++E L ++R + L+ +L D +E WM E +
Sbjct: 2083 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2142
Query: 922 EDSA-EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
+A + ++ K+ L D++ SSI A+ E+ + + TD T L + D
Sbjct: 2143 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET---TDPSTASSLQAKMKDLSA 2199
Query: 981 KSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG 1040
+ E + K + L + KVE+ + +KL + L E
Sbjct: 2200 RFS-EASHKHKETLAKMEELKT---KVELFENLS-------EKLQTFLETKTQALTE--- 2245
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE------LGEKRKGMLEKSCKKF 1094
+ + + + ++ +E+ S L K+ E+ HSLL+ L + +LEK+
Sbjct: 2246 -VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNN-- 2302
Query: 1095 MLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK------ 1148
L ++ E++ I EK+ A+TS + L+ +VL K + K+ ++
Sbjct: 2303 -LSKKFKEMEDTIKEKKEAVTSCQ--EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2359
Query: 1149 DINKVAEDL----ESEGLMAEEVQAVQQQEVY--GMMPRDETDSKTASPWKSARLMVHTV 1202
D+ K ED E L E+Q V + ++ T +K + KS +++
Sbjct: 2360 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2419
Query: 1203 ATFNSIKEL--NERWRSLQQ---------------LAEERSQLLGSAHEVQRFHRDADET 1245
T + +E N+ S+++ L ++ ++L ++Q+ ++
Sbjct: 2420 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2479
Query: 1246 KEWIEEKNQALNTDNYGH---DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
+W+++ N+ D +V+ +++ FE +L +KV L + L++
Sbjct: 2480 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2539
Query: 1303 HPESAEDLQEK--CTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIR 1359
+P++ E + K TE++ W L + R+ KL +S ++L +F + L W+
Sbjct: 2540 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2599
Query: 1360 GLVSS-DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
+VS L+ D ++ Q E R ++ GQ +L+ P ++
Sbjct: 2600 LMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG-EDPSLR- 2657
Query: 1419 KLDILDQERADLEKAWVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK--GD 1475
I+ ++ A + + W L D+C + Q ++ + + L+ D
Sbjct: 2658 --GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2715
Query: 1476 SL------DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAA--GHYAKGDISSRRN 1527
SL D++ ++ + + I ++++I QA + L A Y K ++S +
Sbjct: 2716 SLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLE 2775
Query: 1528 EVLDRWRRLKAQ----MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
+L ++ ++ + + +S S QQ SRD +AW+ K + +++ P
Sbjct: 2776 GILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD---FQAWLDTKKE---EQNKSHPI 2829
Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA-VKARLAALA 1642
+ +L L S + H+ F L A + I G +L+ + GSE A ++ +L +
Sbjct: 2830 SAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEKAALQLQLNTIK 2887
Query: 1643 DQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
W ++ E+ KLKE+ K + ++ W+ + + L + D A N
Sbjct: 2888 TNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENS 2947
Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
+ K + L+ ++ H ++ LN+ A+SL++ D V D+ ++ + + S+
Sbjct: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007
Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG-RDLTGVQNLRKKHKRLEAELAA 1820
+ L + + F+++ E +++L E D G Q K+ +
Sbjct: 3008 KFCLENMTQKFKEFQEVSKES----KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK 3063
Query: 1821 HEPAIQGVLDTGKKLSDDNTI------GKEEIQQRLAQFVEHWKELKQLAAARGQRLEES 1874
A++ +D K+L+ D + G ++ ++ + L Q + LE
Sbjct: 3064 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3123
Query: 1875 LE----YQQFVANVEEEEAWINEKMTLVA-----SEDYGDTLAAIQGLLKKHEAFETDFT 1925
L+ +Q + + + A ++++ +A +E I+ LKK EA
Sbjct: 3124 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS-- 3181
Query: 1926 VHKDRVNDVCT-------NGQDLI----------KKNNHHEENISSKMKGLNGKVSDLEK 1968
D N C DL+ K+ N + ++ + + G + LE+
Sbjct: 3182 --NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE 3239
Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
+ KL E S LQ KA+ E G ++T+ + L+ + + K+E
Sbjct: 3240 FYS----KLKEFSILLQ---KAEEHEESQGPV--GMETETINQQLNMFK-VFQKEEI--E 3287
Query: 2029 GLQAFQQEGIANITALKDQLL--AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE 2086
LQ QQ+ + L L+ AAK ++ +E + RW L A R +L E
Sbjct: 3288 PLQGKQQD----VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3343
Query: 2087 AQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP--------VRCNSLEEIKALREAH 2138
A H + +D + SW + EE + + V ++E K L+
Sbjct: 3344 ALLHCGRFQDAL-------ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLL 3396
Query: 2139 DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELEL 2198
D +S++ + + ++A ++ + L+ W L + R +L
Sbjct: 3397 DDRKSTVEVIKREGEKIATTAEPADKVKILKQ------LSLLDSRWEALLNKAETRNRQL 3450
Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
E + Q+F + ++W+ L++ + ++ LE Q+ K
Sbjct: 3451 -------EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3503
Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQW-DQLDQLGMRMQHNLEQQI 2317
+I L + +G +++ ++K S + +Q W ++ + L+Q +
Sbjct: 3504 DIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQAL 3563
Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEF--------KSCLRSLGYDLPMVEE 2369
G E L M + + DK +L+ Q++ +S LR L D+ + ++
Sbjct: 3564 CNAKIFGEDEVEL----MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3619
Query: 2370 GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAF-RALSSEGKPY 2428
+ D + +Q+ + + +R + K S ++ +AL + +
Sbjct: 3620 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3679
Query: 2429 VTKEEL 2434
T EEL
Sbjct: 3680 STHEEL 3685
Score = 167 bits (423), Expect = 1e-40
Identities = 206/996 (20%), Positives = 441/996 (44%), Gaps = 77/996 (7%)
Query: 1 MDPSGVKVLETAE----DIQERRQQVLDRYHRFKELSTLRRQKLED--SYRFQFFQRDAE 54
M+ +G ++LE + IQE+ Y + KE R L++ S QF + +
Sbjct: 3951 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4010
Query: 55 ELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD----------E 104
LE E++ E + P ++ +++K + ++ N V ++ +
Sbjct: 4011 ILESL--ERIV----ERLRQPPSISAEVEK---IKEQISENKNVSVDMEKLQPLYETLKQ 4061
Query: 105 TGNLMISEG-----HFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ------ 153
G MI+ +++ ++ +L ++ WE + + E+ KLL +L +
Sbjct: 4062 RGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4121
Query: 154 --YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
+ +D D+I D E + G D V+ Q+ E + ++ +E ++ V
Sbjct: 4122 MSLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4175
Query: 212 AAKLIQE-QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETIS 269
++LI P++ ++K DE+N+AW L R KL A + ++ +
Sbjct: 4176 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4235
Query: 270 WIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLS 328
W+ +AS G DL +V+ + + + + + + +++ L +A+ L +
Sbjct: 4236 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4295
Query: 329 ATQ--IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALIN 385
+ + +Q EL W+ + R +L + L +F +L +W+T + L++
Sbjct: 4296 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4355
Query: 386 ADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASDEVREKL 442
+ + D E L +H + ++ AH+ + ++ +++G L+ +AG AS+ ++ KL
Sbjct: 4356 EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN-LQNKL 4414
Query: 443 TVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLL-NEDLGDSLD 500
VL++ +LE E R+QQ + + + F+ + E + W++ E LL ++ LG +
Sbjct: 4415 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4474
Query: 501 SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAME-DVATRRDALLSRRNALH 559
+ + L H + + A+EE +L + +++ + E ++ + L + ++
Sbjct: 4475 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4534
Query: 560 ERAMRRRAQLADSFHLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQG----KVQKH 614
+ R+ +L ++ +L F +S + +W+ + +T PS + ++ +H
Sbjct: 4535 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN--VASRPSLILDTVLFQIDEH 4592
Query: 615 QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISL---WKKLLEATELKG 671
+ F E+++++ +I L+K G L + K +V N +IS+ W+K+++ +G
Sbjct: 4593 KVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERG 4650
Query: 672 IKLREANQQ-QQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNLQKKHALLEADVAA 729
L +A ++ +QF+ + WL E E L S+ + D ++ +H + + A
Sbjct: 4651 RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA 4710
Query: 730 HQDRIDGITIQARQFQDAGHFDAENIKKKQ--EALVARYEALKEPMVARKQKLADSLRLQ 787
D R ++ +N+K L +++ + V R+ KL ++L
Sbjct: 4711 KHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4770
Query: 788 QLFRD-VEDEETWIREKEP-IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
F D ++ W+ EP +A D+ V NL+ H+A Q E+ ++A+ +
Sbjct: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Query: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAES 904
++E + VK ++ EL+ +WE + A + ++ LE +L QA+++ + +
Sbjct: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890
Query: 905 WMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDL 939
W+ E E + DED+ L+ +H+ M L
Sbjct: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL 4926
Score = 160 bits (405), Expect = 1e-38
Identities = 484/2522 (19%), Positives = 976/2522 (38%), Gaps = 424/2522 (16%)
Query: 9 LETAEDIQERRQQVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA 67
++ E Q + Q+ ++ K L+T L +QK+ S + Q +E +K+ ++
Sbjct: 1346 IQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVS-EIEMKQSKMDECQKYAEQYSATV 1402
Query: 68 SDENYKDPTN--LQGKLQKHQAFEAEVQANSGAIV--------KLDETGNLMISEGHFAS 117
D + T + QK +Q+++ I+ + LM FA
Sbjct: 1403 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1462
Query: 118 ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLV----QYLRECEDV------MDWIND 167
++++ L + + L E+ +E K + QK V + L++ E I+
Sbjct: 1463 DSLK----RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1518
Query: 168 KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE---------ERVNEVNQFAAKLIQE 218
+E E+L + L+ +++ K + TD +E E N + + K +QE
Sbjct: 1519 EEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1578
Query: 219 QHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
EE+++ +Q E Q + L Q + +L G E E +
Sbjct: 1579 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1638
Query: 273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
++E+L D G A + + L+ + L + KAL + +L ++ + Q+
Sbjct: 1639 KQEELQ-KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ--KLNEAK-IKCEQL 1694
Query: 333 QVKREELITNWEQIRTLAA-ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELAS 391
+K E+ +++ T A E ++ +L+ +L W++ N D+ S
Sbjct: 1695 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DS 1747
Query: 392 DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
+ AG + HK I+ + F+ D G++ + DEV L + ++
Sbjct: 1748 ERAGTK--------HKQVIEQNGTHFQEGD--GKSAIGE----EDEVNGNL-LETDVDGQ 1792
Query: 452 LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
+ E QQY++ Q + +S+ +A ++ + S + LL+K
Sbjct: 1793 VGTTQENLNQQYQKVK---------AQHEKIISQHQAVII------ATQSAQVLLEKQGQ 1837
Query: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
+ LS +E++ KL +N M+++ + L+ E+ M+ L +
Sbjct: 1838 Y---LSPEEKE---------KLQKN----MKELKVHYETALAES----EKKMKLTHSLQE 1877
Query: 572 SFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSN-LQGKVQKHQAFEAELSANQSRID 629
L++F D E + W+ + + + EA D N L K+++ ++F ++ +++ +
Sbjct: 1878 E--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1935
Query: 630 ALEKAGQKLIDVNHYAKD-------------EVAARMNEVISLWKKLLEATELKGIKLRE 676
+ +G ++++ EV +++ ++ L + G L++
Sbjct: 1936 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1995
Query: 677 ANQQQQFNRNVE-----DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+ Q + ++ HL S+ D N+Q ++ L+ +++ Q
Sbjct: 1996 LVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQ 2054
Query: 732 DRIDGITIQARQFQDA--GHFDAEN-IKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
++ + A DA A+N I+K + +V RYE L + + R +KL +L
Sbjct: 2055 VAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2114
Query: 789 LFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
+D DE E+ ++E+ + ++ +Q+++ K+ L+ +IAG + I
Sbjct: 2115 SVQDGLDEMLDWMGNVESSLKEQGQVPLNST------ALQDIISKNIMLEQDIAGRQSSI 2168
Query: 841 KAVTQKGNAMVEEGH-FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA 899
A+ +K +E A ++AK+ +L+ ++ K + +E+ + F +
Sbjct: 2169 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 2228
Query: 900 NEA-ESWMREKEPIVGSTDY-GKD---------EDSAEALL-KKH----EALMSDLSAYG 943
+E ++++ K + D GKD E ++E L KKH +L+ ++S++G
Sbjct: 2229 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 2288
Query: 944 -----------------------SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
+I+ +E SC++Q+ + + LV +L + +
Sbjct: 2289 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL-----DAFQVLVKSLKSWIK 2343
Query: 981 KSPREVTMKKG-----DILTLLNSTNK--DWWKVEVNDRQ-----GFVPAAYVKKLD-PA 1027
++ ++V + + D+ L T K + W ++ + Q G + + PA
Sbjct: 2344 ETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPA 2403
Query: 1028 QSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGML 1087
++ + ++ G++ + N G S++ K + ++ H +LG K +
Sbjct: 2404 KAIAA---VKSGGAVLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI 2459
Query: 1088 EKSCKKFMLFREANE----LQQWINEKEAALTSEE---VGADLEQVEVLQKKFDDFQKDL 1140
+ K ++A E + QW+ + T + D E V+ ++ F+ +L
Sbjct: 2460 AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2519
Query: 1141 KANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
K N ++++++ +K+ E LE + D+ A WK
Sbjct: 2520 KQNVNKVQELKDKLTELLE-----------------------ENPDTPEAPRWKQM---- 2552
Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIEEKN----- 1253
+ E++ +W+ L QL +R Q L S++ + +F + K+W+ EK
Sbjct: 2553 --------LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2604
Query: 1254 --------QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPE 1305
LNT + + RK + +E+ AA ++ GE P
Sbjct: 2605 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQ-YEQLTAAGQGILSRPGED--------PS 2655
Query: 1306 SAEDLQEKCTELNQAWSSL----GKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
++E+ + Q W SL R D + S Q L D +S ++ L
Sbjct: 2656 LRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KL 2713
Query: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQL--LAHGHYASPEIKQK 1419
SS ++ LE Q+ + EI + + + L L Y E+ ++
Sbjct: 2714 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2773
Query: 1420 LDILDQERADLE-KAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK-GDSL 1477
L+ + + D+E KA + + C F + + W+ ++ N L
Sbjct: 2774 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2833
Query: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA-KGDISSRRNEVLDRWRRL 1536
D +E+LIK H+DF K + Q A + L+ + K + + N + W
Sbjct: 2834 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2893
Query: 1537 KAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS------EKLQTASDESYKDPTNIQLSK 1589
Q+ E+ +KL ES + ++ V+ + WI E+++ D + + + +L
Sbjct: 2894 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2953
Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLI--ERGACAGSEDAVKARLAALADQWQF 1647
L + +H L+ A+ + V ++ ++ E + D V +L + +
Sbjct: 2954 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3013
Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQ 1706
+ QK E + KE+ +Q D + L S+ Y K L + K Q
Sbjct: 3014 MTQKFKEFQEVSKESKRQLQCAKEQLD-------IHDSLGSQAYSNKYLTMLQTQQKSLQ 3066
Query: 1707 LLEADISAHEDRLKDLNSQA-DSLMTSSA-FDTSQVKDKRDTINGRFQKIKSMAASRRAK 1764
L+ + + +DL +A DS TS + + T++ Q++ + K
Sbjct: 3067 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS---QQVDEKCSFLETK 3123
Query: 1765 L-------NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ----NLRKKHKR 1813
L N + F + DDE L GRD +Q ++ K+
Sbjct: 3124 LQGIGHFQNTIREMFSQFAEFDDE---------LDSMAPVGRDAETLQKQKETIKAFLKK 3174
Query: 1814 LEAELAAHEPAIQGVLDTGKKL--SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1871
LEA +A+++ A + T K + +++ + I++ L + +L A AR +++
Sbjct: 3175 LEALMASNDNANK----TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3230
Query: 1872 EESLE-YQQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQGLLKKHEAFE-TDFTVHK 1928
E +++ ++F + ++E + + S+ G I L + F+ + +
Sbjct: 3231 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3290
Query: 1929 DRVNDVCTNGQDLIKK--NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
+ DV GQ LI+ + + + + +N + L K AQR A+L E A L
Sbjct: 3291 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE--ALLHC 3348
Query: 1987 NWKADVVE---SWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT 2042
D +E SW+ + E + + V+ + +Q+ LQ + + +
Sbjct: 3349 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL----LQRLLDDRKSTVE 3404
Query: 2043 ALK---DQLLAAKHVQSKAIEARHASLM-KRWSQLLANSAARKKKL----LEAQSHFRKV 2094
+K +++ K + SL+ RW LL + R ++L + AQ +
Sbjct: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3464
Query: 2095 EDL--FLTFAKKA---------------------SAFNSWFENAEEDLTDPVRCNSLEEI 2131
E L +LT +K A N + L V ++
Sbjct: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3524
Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
+ RE D +S L DF+Q+ ++ Q KS E L++ N KI
Sbjct: 3525 LSSREDKDMVQSKL-----DFSQVWYIEIQEKSHS---------RSELLQQALCN-AKIF 3569
Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT------ 2245
E E+EL E +DKL + Q + W Q++ +L ++ +
Sbjct: 3570 GEDEVELM--NWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3627
Query: 2246 ---------------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEH 2290
++ +LEA K ++++I + + D+ +E+AL L + H
Sbjct: 3628 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST------DVAKTLEQALQLARRL--H 3679
Query: 2291 ST 2292
ST
Sbjct: 3680 ST 3681
Score = 112 bits (281), Expect = 3e-24
Identities = 330/1819 (18%), Positives = 696/1819 (38%), Gaps = 265/1819 (14%)
Query: 669 LKGIKLREANQQQQFNRN-VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
LK L + +++ N V+D+ W+ E++ L ++G DL +V++ + H + +
Sbjct: 629 LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 688
Query: 728 AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
+ + I Q +K L ++Y L +++ L L
Sbjct: 689 EEFESSLKEAKISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQERHLDT---LH 742
Query: 788 QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
+E W+ EKE + + + + H L E+ E IK+V +
Sbjct: 743 NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIA 802
Query: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
++ E H A ++A + +W + Q ++++ ++F DA EA ++R
Sbjct: 803 EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 862
Query: 908 EKEPIVG---STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
+ + S D E L+++ +L Y S+I L +A++ Q
Sbjct: 863 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 922
Query: 965 DETGKEL--VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV 1021
D K + A+ DY++ E+T+ K D L N++++ WKV + VP+
Sbjct: 923 DCPLKTSIPIKAICDYRQ---IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCF 979
Query: 1022 KKLDPAQSA-SRENLLEE--QGSIALRQEQIDNQTRIT------------KEAGSVSLRM 1066
P + A N +E+ Q + L E N + + + S++
Sbjct: 980 TVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKT 1039
Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKK--------FMLFREANELQQWINEKEAALTSEE 1118
E L L + + LE S + L +E N +Q+ E + EE
Sbjct: 1040 MLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREE 1099
Query: 1119 ------------------------------VGADLEQVEVLQKKFD-DFQKDLKANESRL 1147
+ LE+ ++ + F Q+ LK RL
Sbjct: 1100 QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL 1159
Query: 1148 KD----INKVAEDLESEGLMAEEVQAVQQQ---------EVYGM----MPRDETDSKTAS 1190
KD I E+ S+ + V ++ + +VY M + + +T +
Sbjct: 1160 KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 1219
Query: 1191 PWKSARLMVH-----------TVATFNSIKEL---NERWRS--------LQQLAEERSQL 1228
++A +V +A N+I+ L ++WRS L +E +
Sbjct: 1220 NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 1279
Query: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
+ E+ + +++ D +W +EK L + + + + R EG + L D
Sbjct: 1280 KAISDEMFKTYKERDLDFDWHKEKADQL-VERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1338
Query: 1289 VNSLG------ETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD- 1340
+ L ET +R IQ + PE+++ L T+LNQ L + +++K+ +
Sbjct: 1339 YHPLDDWIQQVETTQRKIQENQPENSKTL---ATQLNQQ-KMLVSEIEMKQSKMDECQKY 1394
Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELA-----KDVTGAEALLERHQEHRTEIDARAGTF 1395
+++ + +D R +V S + + + + A+ +++ + RT A
Sbjct: 1395 AEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1454
Query: 1396 QAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF----- 1450
+ +F A +K+ L++E LE+ +++ +++ ELQ +
Sbjct: 1455 TQYIKF----------AGDSLKR----LEEEEKSLEE---EKKEHVEKAKELQKWVSNIS 1497
Query: 1451 --HRDCEQA------ENWMAAREAFLNTEDKGDSLDSVEALIKKHED--FDKAINVQEEK 1500
+D E+A + +++ E E ++L +++ + KH D D+ N E++
Sbjct: 1498 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1557
Query: 1501 IAALQAFADQLIAAG------HYAKGDISSRRNEVLDRWRRLKAQ-------MIEKRSKL 1547
+ LQ + L + GD+ V +R + K + + + ++L
Sbjct: 1558 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1617
Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASD---------ESYKDPTNI---------QLSK 1589
Q E++ + S++ + D E K+ N Q K
Sbjct: 1618 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1677
Query: 1590 LLSKHQKHQAFE--AELHANADRIRGVIDMG-----NSLIERGACAGSEDAVKARLAALA 1642
L + + ++A +L+ A++ + +D E+ A + K ++ L
Sbjct: 1678 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1737
Query: 1643 DQWQFLVQKSAEKS-QKLKEANKQQNFNTGIKDFDFWLSEVEA----LLASEDYGKDLAS 1697
D W V K +E++ K K+ +Q + D + E + LL ++ G+ +
Sbjct: 1738 D-WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1796
Query: 1698 VNNLLKKHQLLEAD----ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
NL +++Q ++A IS H+ + S L + + + K+K N + K
Sbjct: 1797 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK-NMKELK 1855
Query: 1754 IKSMAA----SRRAKLNES--HRLHQFFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQN 1806
+ A ++ KL S L +F D + E W+++ + + + + G D+ G+
Sbjct: 1856 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 1915
Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSD-------------DNTIGKEEIQQRLAQF 1853
K+ K ++ +H+ ++ + +G ++ + D + E+Q++L
Sbjct: 1916 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 1975
Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQF-------VANVEEEEAWINEKMTLVASEDYGD 1905
+ ++ L G L++ ++ YQ + +A ++ EA ++ + SE
Sbjct: 1976 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL----SEPIAV 2031
Query: 1906 TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH---HEENISSKMKGLNGK 1962
+Q L++ +A + + + V + + L+ + +I + + G+
Sbjct: 2032 DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR 2091
Query: 1963 VSDLEKAAAQRKAKLDEN-SAFLQFNWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLL 2020
DL K+ +R KL + L D + W+G E+SLK + +++Q ++
Sbjct: 2092 YEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDII 2151
Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
+K + + Q ++I A+ +++ + + + MK S + ++ +
Sbjct: 2152 SKNIMLEQDIAGRQ----SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2207
Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
K+ L + +LF ++K F A ++ P + ++ L +
Sbjct: 2208 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGK-----DVTELSQYMQE 2262
Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQK 2200
S + L L ++I S + S+ LE+T NL K KE E +++
Sbjct: 2263 STSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL-----VLEKT-NNLSKKFKEMEDTIKE 2316
Query: 2201 EQRRQEENDKLRQEFAQHANAFHQWIQET--RTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
++ + F + WI+ET + ++ S E+ G LE TK+ +
Sbjct: 2317 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLEDTKKLQE 2373
Query: 2259 EIRAMRSQLKKIEDLGAAM 2277
+ +++K+ + G ++
Sbjct: 2374 KWSLKTPEIQKVNNSGISL 2392
Score = 102 bits (255), Expect = 4e-21
Identities = 450/2452 (18%), Positives = 904/2452 (36%), Gaps = 352/2452 (14%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ--IASDENYKDPTNLQGKLQKHQA 87
K L+T R Q+ F R EL W+ EK + +A D + ++ TN+ K H
Sbjct: 726 KLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEEEVAYDWSERN-TNIARKKDYHAE 783
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQ 147
E+ I + E ++ E H A TI + QW +L+
Sbjct: 784 LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ----------L 833
Query: 148 AQKLVQYLRECEDVMDWIND-KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
Q + Q+++E ++ ND KEA L + +Q+K+ +R +
Sbjct: 834 CQCVEQHIKENTAYFEFFNDAKEATDYLRNL------KDAIQRKYS---------CDRSS 878
Query: 207 EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK---LFGAAEVQRF--N 261
+++ + + +EEL++ K N + + L+ + L + ++
Sbjct: 879 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 938
Query: 262 RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL 321
R ++ TI K+ E ++A++ + E V ++C
Sbjct: 939 RQIEITI--YKDDECVLANNSHRAKWKVISP------------TGNEAMVPSVCFTVPPP 984
Query: 322 QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF-RDLTSWVTEM 380
+ A +I+ + + ++T W E H + + + R S V +
Sbjct: 985 NKEAVDLANRIEQQYQNVLTLWH-------ESHINMKSVVSWHYLINEIDRIRASNVASI 1037
Query: 381 KALINADE---LASDVAGAEALLDRHQEHK----GEIDAHEDSFKSADESGQALLAAGHY 433
K ++ + L++ + E L+ QE + +I E + Q LL +
Sbjct: 1038 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1097
Query: 434 ASDEVREKLTVLSEERAALLELWELRRQQYEQCM------DL-QLFYRDTEQVDNWMSKQ 486
E +SE R L L + Q DL + +R TEQ K+
Sbjct: 1098 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE---KLKK 1154
Query: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
E L +DLG + K E+F S +A + L ++QN + +T
Sbjct: 1155 ELERLKDDLG-------TITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 1206
Query: 547 RRDAL----LSRRNALHERAM---------RRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
D L L +N A+ A +AD +++ + +S V+EK
Sbjct: 1207 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1266
Query: 594 K---TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKL-IDVNHYAKD-- 647
+ DE K + + ++ + + ++ + D L + Q + + +++ +D
Sbjct: 1267 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1326
Query: 648 ------EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHL 701
+ + W + +E T+ K I+ + + + ++ + E+E
Sbjct: 1327 GIGKSLKYYRDTYHPLDDWIQQVETTQRK-IQENQPENSKTLATQLNQQKMLVSEIEMKQ 1385
Query: 702 AS-DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQE 760
+ D+ K K + L A D ++ R+ Q + A+ I ++
Sbjct: 1386 SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS----ADLIIQEFM 1441
Query: 761 ALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGV 819
L RY AL M + DSL RL++ + +E+E +KE + + K + +
Sbjct: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-----KKEHVEKAKELQKWVSNI 1496
Query: 820 QNLLKKHQALQAEIAGHEP--RIKAVTQKGNAMVEEGHFAAEDVKAKL------------ 865
LK AE AG P + K +++ + E+ A + ++ L
Sbjct: 1497 SKTLK-----DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1551
Query: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE-----KEPIVGSTDYGK 920
+EL ++ + L+ + + LQ Q D E + E KE + G D
Sbjct: 1552 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLT 1611
Query: 921 DEDSAEALLKKHEALM-----SDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLAL 975
++ L+ EA M +L Y S + L++ Q Q +A E K L
Sbjct: 1612 QTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA----EVVKNTENFL 1665
Query: 976 YDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035
+ EK +E K I LN ++ + Q K+LD + + +
Sbjct: 1666 KENGEKLSQE---DKALIEQKLNEAKIKCEQLNLKAEQS------KKELDKVVTTA---I 1713
Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
EE +A ++ +++T+I +S K E G K K ++E++ F
Sbjct: 1714 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE-------RAGTKHKQVIEQNGTHF- 1765
Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK-DINKVA 1154
Q + K A +EV +L + +V + Q++L ++K K+
Sbjct: 1766 ---------QEGDGKSAIGEEDEVNGNLLETDV-DGQVGTTQENLNQQYQKVKAQHEKII 1815
Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
++ + + Q + +++ + P ++ + ++KEL
Sbjct: 1816 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ------------------KNMKELKVH 1857
Query: 1215 WRSLQQLAEERSQLLGS-AHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQ 1272
+ + +E++ +L S E+++F D E + W+++ Q L N + D+ +
Sbjct: 1858 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1917
Query: 1273 RKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE-------------DLQEKCTELNQ 1319
++ + F D+ + + + + R++++ ++ ++Q K
Sbjct: 1918 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1977
Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVS---SDELAKDVTGAE 1375
+ SL + + L D D + D L++ + S S+ +A D +
Sbjct: 1978 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2037
Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLL-AHGHY--ASPEIKQKLDILDQERADLEK 1432
LE + + +I ++ + ++ + LL A G A +I++ LD + DL K
Sbjct: 2038 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2097
Query: 1433 AWVQRRMMLDQCLELQLFHRD-CEQAENWMAAREAFLNTE-----DKGDSLDSVEALIKK 1486
+ +R L L L +D ++ +WM E+ L + + D + I
Sbjct: 2098 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2157
Query: 1487 HEDF---DKAINVQEEKIAALQAFADQLIAAGHYAK-GDISSRRNEVLDRWRRLKAQMIE 1542
+D +IN EK+ D A+ AK D+S+R +E + + A+M E
Sbjct: 2158 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2217
Query: 1543 KRSKLGESQTLQQFSRDVDEIEAWISEKLQ--TASDESYKDPTNIQ--LSKLLSKHQKHQ 1598
++K ++ F ++++ ++ K Q T D KD T + + + S+ +H+
Sbjct: 2218 LKTK------VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2271
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
LH+ I + V + L+ +++ + EK +
Sbjct: 2272 KHLEVLHSLLKE-----------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 2320
Query: 1659 LKEANKQQN-FNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLLKKHQLLEA 1710
+ +Q + F +K W+ E V+ +ED GK L L +K L
Sbjct: 2321 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2380
Query: 1711 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTING--------RFQKIKSMAASRR 1762
+I + L S +T+ A + VK +NG F K + + ++
Sbjct: 2381 EIQKVNNSGISL-CNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2439
Query: 1763 AKLNESHRLHQFFRDMDDEESWIKEK--KLLVGSEDYGRDLTGVQNLRK----------- 1809
+ SH + D+ + + K KL E+ + +Q + K
Sbjct: 2440 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2499
Query: 1810 -----------KHKRLEAELAAHEPAIQGVLDTGKKLSDDN--TIGKEEIQQRLAQFVEH 1856
++K EAEL + +Q + D +L ++N T +Q L +
Sbjct: 2500 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2559
Query: 1857 WKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL- 1914
W+EL QL R Q+LEES QF + + W+ EK +V+ L+ +L
Sbjct: 2560 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS---VLGPLSIDPNMLN 2616
Query: 1915 ---KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE----------NISSKMKGLNG 1961
++ + +F K + + GQ ++ + ++ K L G
Sbjct: 2617 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2676
Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
++SD Q K + + L + S K D LSS + T
Sbjct: 2677 QLSDRCDWIDQAIVKSTQYQSLL---------------RSLSDKLSDLDNKLSSSLAVST 2721
Query: 2022 KQETFDAGLQAFQQEGIANITALKDQLLAAKHV---QSKAIEARH--ASLMKRWSQLLAN 2076
+ + L+ Q+ I K Q+ A+ + S ++ + A L ++ +L +
Sbjct: 2722 HPDAMNQQLETAQKMK-QEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2780
Query: 2077 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE--NAEEDLTDPVRCNSLEEIKAL 2134
++K H + F + + F +W + E++ + P+ L+ +++L
Sbjct: 2781 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA-KLDVLESL 2839
Query: 2135 REAHDAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
+ H F +L++ + + +AE + + + + + ++ W K +KE
Sbjct: 2840 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2899
Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLD-GSCMVEESGTLESQLEA 2252
RE +L +E+ + ++ + WI + + L + C+ G E+ +
Sbjct: 2900 RENKL-------KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG--ENSIAK 2950
Query: 2253 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQ 2304
K +E+ ++ + + ++ +D + L Q+ D + +
Sbjct: 2951 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 3002
Score = 70.1 bits (170), Expect = 3e-11
Identities = 87/439 (19%), Positives = 179/439 (40%), Gaps = 52/439 (11%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIASDENY 72
+ + ++ D++ S R+ KLE++ F DA + L W+ + Q+A D+
Sbjct: 4738 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4797
Query: 73 KDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
+L + H+AF+ E+ + ++ L + +I S ++ ++ EL +W
Sbjct: 4798 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4857
Query: 132 ELLLEKMREKGIKLLQAQKLVQYLRECED-------VMDWINDKEAIVTSEE-LGQDLEH 183
E + + + + +L LR+ E+ +++W+ + E + L D +
Sbjct: 4858 ETVC------ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4911
Query: 184 VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEE-ELIKTKQDEVNAAWQRLKG 242
+ L + +EF + +N+ ++ HP+ IK + A ++ +
Sbjct: 4912 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4971
Query: 243 LALQRQGKLFGAAEVQRFNRDVDETI-SWIKEKEQLMASDD---FGRDLASVQALLRKHE 298
A Q Q +L A +++ E + +W++ E + D +++ V+AL+ +H+
Sbjct: 4972 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5031
Query: 299 GLERDLAALE---DKV----KALCAEADRLQQSHPL--------------------SATQ 331
++ + DKV K A+ LQ P+ S TQ
Sbjct: 5032 TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQ 5091
Query: 332 IQVKREE---LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
I+ K L++ W+Q+ LA ER +LND+ L +F + + K + +
Sbjct: 5092 IETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNH 5151
Query: 389 LASDVAGAEALLDRHQEHK 407
S V +D+ Q+ K
Sbjct: 5152 KKSRVMDFFRRIDKDQDGK 5170
Score = 60.1 bits (144), Expect = 3e-08
Identities = 64/276 (23%), Positives = 114/276 (41%), Gaps = 12/276 (4%)
Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
+DL +WV EM+ ++ E SD+ E+ L+ H+ I+ E S K A S + A
Sbjct: 649 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 708
Query: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
EKL L + A LL R Q L F W++++E
Sbjct: 709 ---LKLTYAEKLHRLESQYAKLL---NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 762
Query: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
+ D + ++ H + + L +EE I ++ E A +L+ NH A + R A
Sbjct: 763 VAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 822
Query: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK-DPSN--- 606
+ ++ + + + + ++ +FF D+ E ++ +K A Y D S+
Sbjct: 823 MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL-RNLKDAIQRKYSCDRSSSIH 881
Query: 607 -LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDV 641
L+ VQ+ + EL +S I L + +I +
Sbjct: 882 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 917
Score = 57.0 bits (136), Expect = 2e-07
Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 22/279 (7%)
Query: 145 LLQAQKLVQYLRECE-------DVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTD 197
LL++ L Q L E E D+++W+++ + + E G DL VE E +
Sbjct: 628 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE---SHLENHKNV 684
Query: 198 MAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 257
A EE + + + IQ P + K + + + +L + ++ L +
Sbjct: 685 HRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTL 741
Query: 258 QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAE 317
F + W+ EKE+ + D+ ++ H L R+L E+ +K++
Sbjct: 742 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 801
Query: 318 ADR-LQQSHPLSATQIQVKREELITNWEQIRTL--AAERHARLNDSYRLQRFLADFRDLT 374
A++ L ++HP T I+ R + T W I L E+H + N +Y F D ++ T
Sbjct: 802 AEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQCVEQHIKENTAY--FEFFNDAKEAT 858
Query: 375 SWVTEMKALIN---ADELASDVAGAEALLDRHQEHKGEI 410
++ +K I + + +S + E L+ E K E+
Sbjct: 859 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 897
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 278 bits (711), Expect = 5e-74
Identities = 415/1966 (21%), Positives = 824/1966 (41%), Gaps = 178/1966 (9%)
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASET--IRTRLMELHRQ 130
+D LQ + + +AF +++A + ++T +M++ + + I+ L L +Q
Sbjct: 3294 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 3353
Query: 131 WELLLEKM--REKGIK--LLQAQKLVQYLRECEDVMDWINDKEAI-----VTSEELGQDL 181
LL++ RE+ ++ + + ++ L+E ++ + E + +E + Q L
Sbjct: 3354 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 3413
Query: 182 EHVEVLQKKFEEFQTDMAAHEERVNEVNQ----FAAKLIQEQHPEEELIKTKQDEVNAAW 237
+V QK EE + + ++ VN + Q AAK Q E +L D+VNA W
Sbjct: 3414 NMFKVFQK--EEIEP-LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL-----DDVNARW 3465
Query: 238 QRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLR 295
+ L QR +L A RF ++ +SW+ + E+L+A+ + V+A ++
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3525
Query: 296 KHEGLERDLAALEDKVKALCAEADRLQQS-HPLSATQIQVKREELITNWEQIRTLAAERH 354
+ + L+R L + V+ + E +++ + P +I + L + WE + A R+
Sbjct: 3526 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3585
Query: 355 ARLND-SYRLQRFLADFRDLTSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDA 412
+L S Q+F L W+T + K L+N + + + + E + +H+ + +I
Sbjct: 3586 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3645
Query: 413 HEDSFKSADESGQAL-LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-DLQ 470
H A GQ+L + + D V+ KL + E R + +Q + + +
Sbjct: 3646 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3705
Query: 471 LFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLSAQEEKITAL 526
+F D ++ NW+++ L + D S E L K+ + E L ++ AL
Sbjct: 3706 IFGEDEVELMNWLNEVHDKLSKLSVQDY--STEGLWKQQSELRVLQEDILLRKQNVDQAL 3763
Query: 527 DEFATKLIQNNHYAMEDVATRRDALLSRRNALHE------RAMRRRAQLADSFHLQQFFR 580
L Q + + + +A+ +R + + + + + QLA H
Sbjct: 3764 LNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTH--- 3820
Query: 581 DSDELKSWVNE---KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
+EL +W+++ ++ + + K Q +++ + + E N++ +D+L +
Sbjct: 3821 --EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNEVSSA 3877
Query: 638 LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN--QQQQFNRNVEDIELWLY 695
L+++ + E +M + +L+ T + ++ +A + QQF++ + W+
Sbjct: 3878 LLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT 3937
Query: 696 EVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA-GHFD 751
E E L S +D T+ Q +K +E + H+D ID + + A +
Sbjct: 3938 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHKIMTACSEEE 3995
Query: 752 AENIKKKQEALVARYEALKEPMVARKQKL--ADSLRLQQLFRDVEDEETWIREKEPIAAS 809
+++KKK + ++ Y+ + + R +L A SL + Q + E+ W+ E + I +
Sbjct: 3996 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETYEELWPWLTETQSIISQ 4054
Query: 810 TNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
+ ++ ++H+ L+ IA H+P I + + G ++E ++ K
Sbjct: 4055 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA 4114
Query: 869 NQKWEALKAKASQRRQDLEDSLQAQQYFADANEA--ESWMREKEPIVGSTDYGKDEDSAE 926
+ + +K +R L++++ F D + ES R E + + + +
Sbjct: 4115 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4174
Query: 927 ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ----EKS 982
+ +++ + D+ + L+++ + + TD + + V D E
Sbjct: 4175 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4234
Query: 983 PREVTMKKGDILTLLNSTNKDWWK-----VEVNDRQGFVPAAYVKKLDPA----QSASRE 1033
V ++ +L ++ K W V + D Q F+ +DP+ Q + E
Sbjct: 4235 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4294
Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVS------LRMKQVEEL---YHSLLELGEKRK 1084
+ EE + QE++D + E + + K ++EL + SL + + R
Sbjct: 4295 TIREEIDGL---QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4351
Query: 1085 GMLEKSCKKFMLFREANE-LQQWINEKEAALTS-EEVGADLEQVEVLQKKFDDFQKDLKA 1142
LE++ + + +++ + + W++ L S +G DLE V+ ++ F+ +
Sbjct: 4352 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4411
Query: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
+ ++ +N AE L+ ++V +E+D HTV
Sbjct: 4412 QQIEMERLNHQAE------LLLKKVT-------------EESDK-------------HTV 4439
Query: 1203 ATFNSIKELNERWRSLQQ-LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN- 1260
+ + EL W SL++ + + +L G+ + +F DE W+ L+
Sbjct: 4440 Q--DPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4497
Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTELNQ 1319
G D +++ KH + D+ A V ++ + LI+S E A +LQ K LNQ
Sbjct: 4498 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4557
Query: 1320 AWSSLGKRADQRKAKL-GDSHDLQRFLSDFRDLMSWINGI-RGLVSSDELAKDVTGAEAL 1377
W ++ ++ +QRK +L G + F + DL W+ R L++S L A+
Sbjct: 4558 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4617
Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQ 1436
L H E +A+ T+++ Q GQQ+LA A I Q ++ L ++ +E +
Sbjct: 4618 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4677
Query: 1437 RRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAI 1494
R+ L++ L L + FH + NW+ E LN + LD+V I +H+ F +
Sbjct: 4678 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4737
Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRN---EVLDRWRRLKAQMIEKRSKLGESQ 1551
N E+I L L K D+ +N V RW ++ +++E+ L +++
Sbjct: 4738 NSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4795
Query: 1552 T-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
+QF ++ W+ SEK + E DP I+ L++H++ Q H+
Sbjct: 4796 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ--LAQHKEFQKSLGAKHSVY 4853
Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK-QQN 1667
D G SL E+ + A + L+ L D+W + KS E+ KL+EA
Sbjct: 4854 DTTNRT---GRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4910
Query: 1668 FNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
F ++ WL VE LA + +G D+ V NL+ H+ + ++ ++ L
Sbjct: 4911 FTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4969
Query: 1726 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR--------LHQFFRD 1777
A L+ S D+S VK + ++ R++ + +++ S++ +L + R +H
Sbjct: 4970 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 5029
Query: 1778 MDDEESWIKEKKLLVGSEDYGRDLTGV-QNLRKKHKRLEAELAAHEPAIQGVL-----DT 1831
+ + E ++ +L ED R L + KK + AEL VL D+
Sbjct: 5030 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 5089
Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA---ARGQRLEESLEYQQFVANVEEEE 1888
+ TI + ++ LA +H + L A A+ + LE L + Q
Sbjct: 5090 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQ--------- 5140
Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
W +T E + ++ L+ +H+ F + T + V+ V
Sbjct: 5141 -WAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5185
Score = 265 bits (676), Expect = 5e-70
Identities = 503/2529 (19%), Positives = 1024/2529 (40%), Gaps = 298/2529 (11%)
Query: 49 FQRDAEELEKWIQEKLQIASDENYKDPTN-----LQGKLQKHQAFEAEVQANSGAIVK-L 102
FQ+ + + + W+ K + ++N P + L+ ++ H+ F + A S K +
Sbjct: 2943 FQQMSRDFQAWLDTKKE---EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2999
Query: 103 DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA-QKLVQYLRECEDV 161
E NL++ ++ +L + W+ ++++E+ KL ++ +K ++Y + E +
Sbjct: 3000 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 3059
Query: 162 MDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
WI+ + + + D E K + Q +M H V +N A L+
Sbjct: 3060 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 3119
Query: 222 EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE-----KEQ 276
++E++ DE + Q++ + Q K F + + ++ E K KEQ
Sbjct: 3120 DKEVVT---DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQ 3176
Query: 277 LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
L D G S L + ++ L AL+ +V A RL Q + A+ +
Sbjct: 3177 LDIHDSLGSQAYS-NKYLTMLQTQQKSLQALKHQVDL----AKRLAQDLVVEASDSKGTS 3231
Query: 337 EELITNWEQIRTLAAERHARLNDSY---------RLQ---RFLADFRDLTSWVTEMKALI 384
+ L+ Q+ T+A E H+ L+ +LQ F R++ S E +
Sbjct: 3232 DVLL----QVETIAQE-HSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDEL 3286
Query: 385 NADELASDVAGAEALLDRHQEHKG---EIDAHEDSFKSADESGQALLAAGHYASDEV--R 439
D +A AE L + + K +++A S +A+++ + +LA + D V +
Sbjct: 3287 --DSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3344
Query: 440 EKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDTEQVDNWMSKQEAFLLNED-LGD 497
L LS++ LL+ + R +Q E + L+ FY ++ + K E ++ +G
Sbjct: 3345 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 3404
Query: 498 SLDSVEALLKKHEDFEKS----LSAQEEKITALDEFATKLIQNNHYAMEDVATRR----- 548
+++ L + F+K L +++ + L + LIQ+ A + +T+
Sbjct: 3405 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ---GLIQS---AAKSTSTQGLEHDL 3458
Query: 549 DALLSRRNALHERAMRRRAQLADSF-HLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN- 606
D + +R L+++ +R AQL ++ H +F + L SW+ + + ++ K PS
Sbjct: 3459 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ--KPPSAE 3516
Query: 607 ---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA-KDEVAARMNEVISLWKK 662
++ ++Q+ + + L +S ++ +++ G+K+ A K ++ +++ + S W+
Sbjct: 3517 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3576
Query: 663 LLEATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLAS-DDYGKDLTNVQNLQKKH 720
LL E + +L + QQF+ +E + WL +E L + + G + ++ +H
Sbjct: 3577 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3636
Query: 721 ALLEADVAAHQDRI-DGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
LE D+ H + ++I + D + ++ K + Y ++E +R +
Sbjct: 3637 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3696
Query: 780 LADSLRLQQLFRDVEDE-ETWIRE-KEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHE 837
L +L ++F + E E W+ E + ++ + + G+ + + LQ +I +
Sbjct: 3697 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3756
Query: 838 PRIKAVTQKGNAMVEEGHFAAEDV---KAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQ 893
+ G ++++ ++V + KL + +++ + ++ + LE +LQ A+
Sbjct: 3757 QNVDQALLNGLELLKQT--TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3814
Query: 894 QYFADANEAESWMR--EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
+ + E +W+ E E + T K E++++A ++ E L + + + +L E
Sbjct: 3815 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNE 3873
Query: 952 QAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVND 1011
S ++ P G E ++A + + L++ T KVE D
Sbjct: 3874 -VSSALLELVPWRAREGLEKMVA--------------EDNERYRLVSDTITQ--KVEEID 3916
Query: 1012 RQGFVPAAYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITK------------ 1057
+ + D S E L G I L Q+Q Q ++ K
Sbjct: 3917 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3976
Query: 1058 ------------------EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
E S+ ++ +V + Y ++ ++ +R LE++ F E
Sbjct: 3977 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 4036
Query: 1100 A-NELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL 1157
EL W+ E ++ ++ A + E + Q++ ++ + ++ + +NK L
Sbjct: 4037 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 4096
Query: 1158 ----ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNE 1213
EG +E + V +Y + D + VA +I + +
Sbjct: 4097 LELSPGEGFSIQE-KYVAADTLYSQIKED--------------VKKRAVALDEAISQSTQ 4141
Query: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
+ Q+ E +++ + + ++ KE I E N D+ +Q L
Sbjct: 4142 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK------NVSVDMEKLQPLYE 4195
Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
L G+++ + ++ I SA+ +Q+K ++ W ++ ++R+A
Sbjct: 4196 T-------LKQRGEEMIARSGGTDKDI-----SAKAVQDKLDQMVFIWENIHTLVEEREA 4243
Query: 1334 KLGDSHDL-QRFLSDFRDLMSWINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDAR 1391
KL D +L ++F D L+ I + + ++ D + + E + R EID
Sbjct: 4244 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 4303
Query: 1392 AGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
G +L+A G P +K+ +D L+ L KAW R L++ ++ +
Sbjct: 4304 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 4363
Query: 1451 HRDCEQAE-NWM-AAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508
++D QA +W+ A + G L++V+ I++ + F Q+ ++ L A
Sbjct: 4364 YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQA 4423
Query: 1509 DQLI--AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEA 1565
+ L+ K + E+ W L+ ++I ++ KL G L QF +DE+ A
Sbjct: 4424 ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 4483
Query: 1566 WIS--EKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1623
W++ E L + DP I++ KH + ++ A+ + V GN LIE
Sbjct: 4484 WLTHTEGLLSEQKPVGGDPKAIEIELA-----KHHVLQNDVLAHQSTVEAVNKAGNDLIE 4538
Query: 1624 RGACAGSEDA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSE 1681
+ AG E + ++ +L L +WQ +++K+ ++ Q+L A +Q + F+ I+D WL++
Sbjct: 4539 --SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4596
Query: 1682 VEA-LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDT-SQ 1739
E LLAS+ G + L H + A A E+ K L + ++ +
Sbjct: 4597 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4656
Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLH-QFFRDMDDEESWIK--EKKLLVGSED 1796
+ + + +++ +++ R+ KL E+ L +F + D +W+ E+ L V S
Sbjct: 4657 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4716
Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE---IQQRLAQF 1853
L V +HK E+ +H I + TG L + K++ I+ L
Sbjct: 4717 -SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISV 4773
Query: 1854 VEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQ 1911
W+++ Q RG+ L+++ + +QF + W+ E + SE + + I+
Sbjct: 4774 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4833
Query: 1912 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENIS--SKMKGLNGKVSDLEKA 1969
L +H+ F+ + G+ L +K + ++N+ + L K +
Sbjct: 4834 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4893
Query: 1970 AAQRKAKLDENSAFL-QFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTKQETF 2026
+ +R+ KL+E F QF + W+ E L D +G D+ V L+ + F
Sbjct: 4894 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAF 4952
Query: 2027 DAGLQAFQQEGIANITALKD---QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKK 2083
L + +++ ALK +L+ S ++ + L RW + A S +++ +
Sbjct: 4953 QKELG----KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 5008
Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLT-DPVRCNSLEEIKALREAHDAFR 2142
L ++ R+ E+ F A W AE+ L V + + ++ L + H F
Sbjct: 5009 L---EAALRQAEE----FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 5061
Query: 2143 SSLSSAQADFNQLAELDRQIKSFRVASNPYT---WFTM------EALEETWRNLQK---- 2189
L +A+ N+ + + + + T W T+ E L ++ Q+
Sbjct: 5062 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 5121
Query: 2190 ----IIKERELELQKEQRRQEEN---DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEE 2242
I K+ LE + E DK ++ Q I E +T++ + M +
Sbjct: 5122 LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEE---MTRK 5178
Query: 2243 SGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVG-------- 2294
++ + KR+ + +++S + + D G A + + Y S
Sbjct: 5179 QPDVDKVTKTYKRRAADPSSLQSHIPVL-DKGRAGRKRFPASSLYPSGSQTQIETKNPRV 5237
Query: 2295 --LAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM---------------- 2336
L +W Q+ L + + L + E L+EF+
Sbjct: 5238 NLLVSKWQQVWLLALERRRKLNDALDRL-------EELREFANFDFDIWRKKYMRWMNHK 5290
Query: 2337 -------FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2389
F+ DKD+ G++ QEF + S + + E A+ D D + DG
Sbjct: 5291 KSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL-------EMSAVADIFDRDGDG 5343
Query: 2390 HVSLQEYMA 2398
++ E++A
Sbjct: 5344 YIDYYEFVA 5352
Score = 233 bits (594), Expect = 2e-60
Identities = 446/2453 (18%), Positives = 976/2453 (39%), Gaps = 266/2453 (10%)
Query: 21 QVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIAS--DENYKDPTN 77
++ ++ +L+ R+QKLE+S FQ +L++W+ EK + S DP
Sbjct: 2693 EIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2752
Query: 78 LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTRLMELHRQWELL 134
L + Q+ Q E +L G ++S E ++ +L + ++W+ L
Sbjct: 2753 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2812
Query: 135 LEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSEE-LGQDLEHVE 185
++ ++ +K Q Q L++ L + D+ + ++ A+ T + + Q LE +
Sbjct: 2813 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2872
Query: 186 VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNA---AWQRLKG 242
++++ ++ + + + +++ L++E++ + EL + + + + Q+ +
Sbjct: 2873 KMKQEIQQEKKQIKVAQALCEDLSA----LVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2928
Query: 243 LALQRQGKLFGAAEVQRFNRDVDETISWIK-EKEQLMASDDFGRDLASVQALLRKHEGLE 301
Q + + Q+ +RD +W+ +KE+ S L +++L++ H+
Sbjct: 2929 HVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2985
Query: 302 RDLAALEDKVKALCAEADRL---QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLN 358
+ L A + AE + L Q +A Q+Q+ + TNW+ ER +L
Sbjct: 2986 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT--IKTNWDTFNKQVKERENKLK 3043
Query: 359 DSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSF 417
+S + ++ L W+ + + + + D A E + + + + E+D H
Sbjct: 3044 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 3103
Query: 418 KSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQ---CMD-LQLFY 473
+ + + +LL+ + V+++E +L++ ++ +Q C++ + +
Sbjct: 3104 ELLNNTANSLLSVCEIDKE-------VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3156
Query: 474 RDTEQVDNWMSKQEAFLLNE-DLGDSLDSVEALLKKH----EDFEKSLSAQEEKITALDE 528
++ ++V +Q + D+ DSL S +A K+ + +KSL A + ++
Sbjct: 3157 KEFQEVSKESKRQLQCAKEQLDIHDSLGS-QAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3215
Query: 529 FATKLI--QNNHYAMEDVATRRDALLSRRNALHERAMRR----RAQLADSFHLQQFFRDS 582
A L+ ++ DV + + + + L ++ + +L H Q R+
Sbjct: 3216 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3275
Query: 583 DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVN 642
+ ++++ + +D LQ + + +AF +L A + D K + ++
Sbjct: 3276 FSQFAEFDDELDSMAPVG-RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATE 3334
Query: 643 HYAKDEVAARMN-EVISLW-KKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEG 699
+ D V + + E +S KLL+ + + ++ ++ ++F +++ + L + E
Sbjct: 3335 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3394
Query: 700 HLASDD-YGKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQF--QDAGHFDAENI 755
H S G + + Q L + ++ Q + + + A + +
Sbjct: 3395 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3454
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-VEDEETWIREKEPIAASTNR-G 813
+ + + AR++ L + + R +L ++L F+D +E +W+ + E + A+
Sbjct: 3455 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS 3514
Query: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQK 871
+ V+ +++ + LQ + + ++ + ++G + A+ VK +L L+ +
Sbjct: 3515 AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSR 3573
Query: 872 WEALKAKASQRRQDLED-SLQAQQYFADANEAESWMREKEP-IVGSTDYGKDEDSAEALL 929
WEAL KA R + LE S+ AQQ+ W+ E +V G E +
Sbjct: 3574 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3633
Query: 930 KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMK 989
+H+AL D+ + + QA S Q + K++V + D+ + E+ K
Sbjct: 3634 AQHKALEDDIINHNKHLH----QAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3689
Query: 990 KGDILTLLNST-------NKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
LL +D W EV+D+ + KL Q S E L +
Sbjct: 3690 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK--------LSKLS-VQDYSTEGLWK 3740
Query: 1038 EQGS-------IALRQEQID----NQTRITKEAGS-----VSLRMKQVEELYHSLLELGE 1081
+Q I LR++ +D N + K+ + +++ ++ Y + +L
Sbjct: 3741 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3800
Query: 1082 KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV----GADLEQVEVLQKKFDDF 1136
LE++ + +E L W+++ E L S E G + Q ++ K +
Sbjct: 3801 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK---EL 3857
Query: 1137 QKDLKANESRLKDINK--------------------VAEDLESEGLMAEEV-QAVQQQEV 1175
+K+ K N++ L +N+ VAED E L+++ + Q V++ +
Sbjct: 3858 KKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDA 3917
Query: 1176 YGMMPRD-------------ETDSKTAS--------PWKSARLMV--------------- 1199
+ + ET+ K S SA+L V
Sbjct: 3918 AILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3977
Query: 1200 -------HTVATFNSIKELNERWRSLQQL-----------AEERSQLLGSAHEVQRFHRD 1241
H + T S +E + L ++ +E QL + V +F
Sbjct: 3978 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 4037
Query: 1242 ADETKEWIEEKNQALNT-DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI 1300
+E W+ E ++ + +++ Q +H +A ++ + +T +L+
Sbjct: 4038 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 4097
Query: 1301 QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRD--LMSWINGI 1358
+ P +QEK + +S + + +R L ++ D D L S +
Sbjct: 4098 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4157
Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
L ++ +V + + ++ +++ ++ +Q G++++A +I
Sbjct: 4158 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4217
Query: 1419 KL--DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN-WMAAREAFLNTEDKGD 1475
K D LDQ + W ++++ E +L E AE W + +D D
Sbjct: 4218 KAVQDKLDQ----MVFIWENIHTLVEE-REAKLLDV-MELAEKFWCDHMSLIVTIKDTQD 4271
Query: 1476 SLDSVE------ALIKKHEDFDKAIN-----VQEEKIAALQAFADQLIAAGHYAKGDISS 1524
+ +E +++K+ ++ + I +QEE + ++ + A G K +
Sbjct: 4272 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4331
Query: 1525 RRNEVLDRWRRLKAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS---EKLQTASDESYK 1580
+E+ W L ++ KL E+ Q Q+ + + W+ KL + S
Sbjct: 4332 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----- 4386
Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
P L + + ++ + F++E + + + L+++ + V+ L
Sbjct: 4387 -PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 4445
Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQN-FNTGIKDFDFWLSEVEALLASED-YGKDLASV 1698
L W L ++ + KL+ A F + + WL+ E LL+ + G D ++
Sbjct: 4446 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4505
Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGRFQKIKSM 1757
L KH +L+ D+ AH+ ++ +N + L+ SSA + S +++K + +N R+Q +
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4565
Query: 1758 AASRRAKLNESHRLHQFFR-DMDDEESWIK--EKKLLVGSEDYGRDLTGVQNLRKKHKRL 1814
R+ +L+ + R + F +++D + W+ E+ LL G T + L H +
Sbjct: 4566 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV-HMEV 4624
Query: 1815 EAELAAHEPAIQGVLDTGKK-LSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
A A E + ++ G++ L+ + I Q + E W+ ++ R +LEE
Sbjct: 4625 CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4684
Query: 1874 SLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931
+L +F ++++ W+ + + TL + L + + +H+ F + H++++
Sbjct: 4685 ALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQI 4744
Query: 1932 NDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWK 1989
++ G L + + I + + + + + + +R LD+ QF+
Sbjct: 4745 IELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEA 4804
Query: 1990 ADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT-----A 2043
+ W+ E E SL ++ + D ++T L + + F L A + + + T +
Sbjct: 4805 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA--KHSVYDTTNRTGRS 4862
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
LK++ A + ++ + L +W + S R+ KL EA + D
Sbjct: 4863 LKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL----- 4915
Query: 2104 KASAFNSWFENAEEDLTD--PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
A W E L + PV ++ + L + H AF+ L + L R+
Sbjct: 4916 --QALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4972
Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANA 2221
+ + + M+ L W + + ++ L+ R+ EE F +A
Sbjct: 4973 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEE-------FHSVVHA 5025
Query: 2222 FHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
+W+ E L + ++ L + ++ K +++ R++L K +G
Sbjct: 5026 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMG 5078
Score = 226 bits (576), Expect = 2e-58
Identities = 433/2280 (18%), Positives = 920/2280 (40%), Gaps = 246/2280 (10%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF-FQRDAEELEKWIQEKLQIASDENY- 72
+Q + + + F + R KL++S ++ E L WI + + +
Sbjct: 3017 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 3076
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
DP + + K ++ + E+ + G + L+ T N ++S E + L ++ +
Sbjct: 3077 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 3136
Query: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND-----KEAIVTSEELGQDL---EHV 184
++ E++ K L + + Q +E ++V KE + + LG +++
Sbjct: 3137 MVTEQLHSKKFCL---ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3193
Query: 185 EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL------IKTKQDEVNAAWQ 238
+LQ + Q + A + +V+ + A L+ E + ++T E + Q
Sbjct: 3194 TMLQTQ----QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3249
Query: 239 RLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ------- 291
++ + KL G Q R++ + ++ MA GRD ++Q
Sbjct: 3250 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP--VGRDAETLQKQKETIK 3307
Query: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR--EELITNWEQIRTL 349
A L+K E L A D C +++ P + +KR E L ++
Sbjct: 3308 AFLKKLEAL----MASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDR 3360
Query: 350 AAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEH-- 406
A R ++ + RL+ F + ++ + + + + E + G E Q +
Sbjct: 3361 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE----HEESQGPVGMETETINQQLNMF 3416
Query: 407 ----KGEIDAHEDSFKSADESGQALLAAGHYAS---------DEVREKLTVLSEERAALL 453
K EI+ + + + GQ L+ + ++ D+V + L+++ A
Sbjct: 3417 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA--- 3473
Query: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS-LDSVEALLKKHEDF 512
+ Q E + F E + +WM E + N+ + V+A +++ +
Sbjct: 3474 ---QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL 3530
Query: 513 EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-SRRNALHERAMRRRAQLAD 571
++ L ++ + + K+ A + ++ +LL SR AL +A R QL
Sbjct: 3531 QRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3590
Query: 572 -SFHLQQFFRDSDELKSWVN--EKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
S QQF + L W+ EK + S L+ ++ +H+A E ++ + +
Sbjct: 3591 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3650
Query: 629 DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV- 687
GQ L ++ ++ + +W +E E K E QQ N +
Sbjct: 3651 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW--YIEIQE-KSHSRSELLQQALCNAKIF 3707
Query: 688 --EDIEL--WLYEVEGHLAS---DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
+++EL WL EV L+ DY + + Q + +L+ D+ + +D +
Sbjct: 3708 GEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELRVLQEDILLRKQNVDQALLN 3765
Query: 741 ARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEE- 797
+ Q G + I+ K EA+ ARY+ + + + L +L+L + +E
Sbjct: 3766 GLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3824
Query: 798 TWIR--EKEPIAASTN--RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
TW+ E E ++ T +G++ Q K+ L+ E ++ + ++ + +A++E
Sbjct: 3825 TWLDKVEVELLSYETQVLKGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLEL 3881
Query: 854 GHFAA-EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE-SWMREKEP 911
+ A E ++ + E N+++ + +Q+ ++++ ++ Q F A +AE SW+ E E
Sbjct: 3882 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3941
Query: 912 ---IVGSTDYGKDEDSAEALLKK--------HEALMSDLSAYGSSIQAL--REQAQSCRQ 958
+G +D+ SA+ ++K H+ ++ DL G I E+ QS ++
Sbjct: 3942 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 4001
Query: 959 QVAPTDDETGKELVLALYDY--QEKSPREVTMKKGDILTLLNSTNKDW--------WKVE 1008
++ + VL YD Q S R + +++ L N+ W W E
Sbjct: 4002 KL---------DKVLKNYDTICQINSERYLQLERAQSLV-----NQFWETYEELWPWLTE 4047
Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITK--------EAG 1060
+PA ++ Q L E IA + ID + E
Sbjct: 4048 TQSIISQLPAPALEYETLRQQQEEHRQLREL--IAEHKPHIDKMNKTGPQLLELSPGEGF 4105
Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVG 1120
S+ + + LY + E +KR L+++ + F + ++ Q + + E +
Sbjct: 4106 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILE------SLERIV 4157
Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQ---QQEVYG 1177
L Q + + + ++ + N++ D+ K+ E+ EE+ A +++
Sbjct: 4158 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4217
Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAE----ERSQLLGSAH 1233
+D+ D W++ +HT+ ++E + + +LAE + L+ +
Sbjct: 4218 KAVQDKLDQMVFI-WEN----IHTL-----VEEREAKLLDVMELAEKFWCDHMSLIVTIK 4267
Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
+ Q F RD ++ G D + V+ Q E ++ L ++++ +
Sbjct: 4268 DTQDFIRDLEDP----------------GIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4311
Query: 1294 ETAERLIQSHPESAEDLQEKCT-ELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
LI + E + + +K ELN AW SL K R KL ++ ++ + +
Sbjct: 4312 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4371
Query: 1352 MSWINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
W++ G L S + D+ + +E ++ ++E + + + LL
Sbjct: 4372 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4431
Query: 1411 YASPE--IKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAF 1467
S + ++ L L LE+ + R+ L+ L L F ++ W+ E
Sbjct: 4432 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4491
Query: 1468 LNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
L+ + G ++E + KH + + + A+ + LI + + +
Sbjct: 4492 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4551
Query: 1527 NEVLD-RWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEAWISE--------KLQTASD 1576
EVL+ RW+ + + +++ +L G + + F ++++++ W+++ K
Sbjct: 4552 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4611
Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS-EDAVK 1635
E+ K+ N+ H A A + + ++ G ++ R C S E +
Sbjct: 4612 ETAKEQLNV-----------HMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNID 4658
Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALL-ASEDYGK 1693
+ L ++W+ + K E+ KL+EA N F+ ++DF WL++ E L +
Sbjct: 4659 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSL 4718
Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQ 1752
L +V + +H++ ++++H +++ +L+ L S D +K+ ++ R++
Sbjct: 4719 ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWE 4778
Query: 1753 KIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTGVQNLRKK 1810
K+ R L+++ R QF W++E + + SE + D ++ +
Sbjct: 4779 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4838
Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ--QRLAQFVEHWKELKQLAAARG 1868
HK + L A TG+ L + ++ + ++ L++ + W + + R
Sbjct: 4839 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4898
Query: 1869 QRLEESLEYQ-QFVANVEEEEAWINEKMTLVASED--YGDTLAAIQGLLKKHEAFETDFT 1925
+LEE+L + QF ++ W+ +A + +GD + + L+ H+AF+ +
Sbjct: 4899 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELG 4957
Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ 1985
V + + ++LI+ + + +M+ L+ + + + ++ +L+ +A Q
Sbjct: 4958 KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLE--AALRQ 5015
Query: 1986 FNWKADVVES---WIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
VV + W+ E E +L+ D +++TL+ + + F L+ + E +
Sbjct: 5016 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAE-LNKA 5074
Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMK-RWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
T + D +LA H S ++++ R+ ++LA + +++L A + ++L
Sbjct: 5075 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL-- 5132
Query: 2101 FAKKASAFNSWFENAEEDLTDP---VRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
A +W + AE LTD V +EE+KAL H F ++ Q D +++ +
Sbjct: 5133 -----EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5187
Score = 188 bits (477), Expect = 6e-47
Identities = 502/2586 (19%), Positives = 1010/2586 (39%), Gaps = 326/2586 (12%)
Query: 14 DIQERRQ---QVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEEL-EKWIQEKLQIAS 68
++ E+RQ + D + K +S + + E F + + A++L E+W +QI
Sbjct: 1399 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI-- 1456
Query: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
D +D L+G + + + I +++ T + S+T+ T+L
Sbjct: 1457 DNRLRD---LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---- 1509
Query: 129 RQWELLLEKMREKGIKLLQAQKLV-QYLRECEDVMDWINDKEAIVTSEELG-----QDLE 182
Q ++L+ ++ K K+ + QK QY +D A+V S++ +
Sbjct: 1510 NQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQS 1569
Query: 183 HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE-LIKTKQDEVNAAWQRLK 241
+++ ++F + +T A + + +FA ++ EE+ L + K++ V A + K
Sbjct: 1570 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1629
Query: 242 GLA-LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH--- 297
++ + + K A F++ + +KEQL + L ++Q L KH
Sbjct: 1630 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEA------LQTIQLFLAKHGDK 1683
Query: 298 ------EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
LE+ + L++ L +E+ + Q S T VK EE I A
Sbjct: 1684 MTDEERNELEKQVKTLQESYNLLFSESLKQLQE---SQTSGDVKVEEKIV---------A 1731
Query: 352 ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
ER Q + + + +T+ + + + A + L ++Q + E+
Sbjct: 1732 ERQ---------QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1782
Query: 412 AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
K S QAL + ++E LS+E AL+E + + +C L L
Sbjct: 1783 ------KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKIKCEQLNL 1834
Query: 472 FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
EQ SK+E LD V K E + + Q E+ E
Sbjct: 1835 ---KAEQ-----SKKE-----------LDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1875
Query: 532 KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
+ N E T+ ++ + N H + ++ + + + ++D + V
Sbjct: 1876 DWLSNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGEEDEVNGNLLETD-VDGQVGT 1933
Query: 592 KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA 651
+ + K + + + +HQA + A QS LEK GQ L + K+++
Sbjct: 1934 TQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYL---SPEEKEKLQK 1987
Query: 652 RMNEVISLWKKLLEATELKGIKLREANQQQ--QFNRNVEDIELWLYEVEGHLASDDYGKD 709
M E+ ++ L +E K +KL + Q++ +F+ + + E WL + E L + + G D
Sbjct: 1988 NMKELKVHYETALAESEKK-MKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 2046
Query: 710 -LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF---------QDAGHFDAE----NI 755
+ + K+ DV +H+ + ITI + +D G D +
Sbjct: 2047 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 2106
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED---------EETWIRE-KEP 805
++K + R+ +L L D + Q + D E T + EP
Sbjct: 2107 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2166
Query: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGHF--AAEDVK 862
IA D +Q L++ +ALQ +I+ + ++ + + +++ G A D++
Sbjct: 2167 IAV------DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2220
Query: 863 AKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA-NEAESWMREKEPIVGSTDYGKD 921
L ++ ++E L ++R + L+ +L D +E WM E +
Sbjct: 2221 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2280
Query: 922 EDSA-EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
+A + ++ K+ L D++ SSI A+ E+ + + TD T L + D
Sbjct: 2281 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET---TDPSTASSLQAKMKDLSA 2337
Query: 981 KSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG 1040
+ E + K + L + KVE+ + +KL + L E
Sbjct: 2338 RFS-EASHKHKETLAKMEELKT---KVELFENLS-------EKLQTFLETKTQALTE--- 2383
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE------LGEKRKGMLEKSCKKF 1094
+ + + + ++ +E+ S L K+ E+ HSLL+ L + +LEK+
Sbjct: 2384 -VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNN-- 2440
Query: 1095 MLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK------ 1148
L ++ E++ I EK+ A+TS + L+ +VL K + K+ ++
Sbjct: 2441 -LSKKFKEMEDTIKEKKEAVTSCQ--EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2497
Query: 1149 DINKVAEDL----ESEGLMAEEVQAVQQQEVY--GMMPRDETDSKTASPWKSARLMVHTV 1202
D+ K ED E L E+Q V + ++ T +K + KS +++
Sbjct: 2498 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2557
Query: 1203 ATFNSIKEL--NERWRSLQQ---------------LAEERSQLLGSAHEVQRFHRDADET 1245
T + +E N+ S+++ L ++ ++L ++Q+ ++
Sbjct: 2558 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2617
Query: 1246 KEWIEEKNQALNTDNYGH---DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
+W+++ N+ D +V+ +++ FE +L +KV L + L++
Sbjct: 2618 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2677
Query: 1303 HPESAEDLQEK--CTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIR 1359
+P++ E + K TE++ W L + R+ KL +S ++L +F + L W+
Sbjct: 2678 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2737
Query: 1360 GLVSS-DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
+VS L+ D ++ Q E R ++ GQ +L+ P ++
Sbjct: 2738 LMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG-EDPSLR- 2795
Query: 1419 KLDILDQERADLEKAWVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK--GD 1475
I+ ++ A + + W L D+C + Q ++ + + L+ D
Sbjct: 2796 --GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2853
Query: 1476 SL------DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAA--GHYAKGDISSRRN 1527
SL D++ ++ + + I ++++I QA + L A Y K ++S +
Sbjct: 2854 SLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLE 2913
Query: 1528 EVLDRWRRLKAQ----MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
+L ++ ++ + + +S S QQ SRD +AW+ K + +++ P
Sbjct: 2914 GILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD---FQAWLDTKKE---EQNKSHPI 2967
Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA-VKARLAALA 1642
+ +L L S + H+ F L A + I G +L+ + GSE A ++ +L +
Sbjct: 2968 SAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEKAALQLQLNTIK 3025
Query: 1643 DQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
W ++ E+ KLKE+ K + ++ W+ + + L + D A N
Sbjct: 3026 TNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENS 3085
Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
+ K + L+ ++ H ++ LN+ A+SL++ D V D+ ++ + + S+
Sbjct: 3086 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3145
Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG-RDLTGVQNLRKKHKRLEAELAA 1820
+ L + + F+++ E +++L E D G Q K+ +
Sbjct: 3146 KFCLENMTQKFKEFQEVSKES----KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK 3201
Query: 1821 HEPAIQGVLDTGKKLSDDNTI------GKEEIQQRLAQFVEHWKELKQLAAARGQRLEES 1874
A++ +D K+L+ D + G ++ ++ + L Q + LE
Sbjct: 3202 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3261
Query: 1875 LE----YQQFVANVEEEEAWINEKMTLVA-----SEDYGDTLAAIQGLLKKHEAFETDFT 1925
L+ +Q + + + A ++++ +A +E I+ LKK EA
Sbjct: 3262 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS-- 3319
Query: 1926 VHKDRVNDVCT-------NGQDLI----------KKNNHHEENISSKMKGLNGKVSDLEK 1968
D N C DL+ K+ N + ++ + + G + LE+
Sbjct: 3320 --NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE 3377
Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
+ KL E S LQ KA+ E G ++T+ + L+ + + K+E
Sbjct: 3378 FYS----KLKEFSILLQ---KAEEHEESQGPV--GMETETINQQLNMFK-VFQKEEI--E 3425
Query: 2029 GLQAFQQEGIANITALKDQLL--AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE 2086
LQ QQ+ + L L+ AAK ++ +E + RW L A R +L E
Sbjct: 3426 PLQGKQQD----VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3481
Query: 2087 AQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP--------VRCNSLEEIKALREAH 2138
A H + +D + SW + EE + + V ++E K L+
Sbjct: 3482 ALLHCGRFQDAL-------ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLL 3534
Query: 2139 DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELEL 2198
D +S++ + + ++A ++ + L+ W L + R +L
Sbjct: 3535 DDRKSTVEVIKREGEKIATTAEPADKVKILKQ------LSLLDSRWEALLNKAETRNRQL 3588
Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
E + Q+F + ++W+ L++ + ++ LE Q+ K
Sbjct: 3589 -------EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3641
Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQW-DQLDQLGMRMQHNLEQQI 2317
+I L + +G +++ ++K S + +Q W ++ + L+Q +
Sbjct: 3642 DIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQAL 3701
Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEF--------KSCLRSLGYDLPMVEE 2369
G E L M + + DK +L+ Q++ +S LR L D+ + ++
Sbjct: 3702 CNAKIFGEDEVEL----MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3757
Query: 2370 GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAF-RALSSEGKPY 2428
+ D + +Q+ + + +R + K S ++ +AL + +
Sbjct: 3758 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3817
Query: 2429 VTKEEL 2434
T EEL
Sbjct: 3818 STHEEL 3823
Score = 167 bits (423), Expect = 1e-40
Identities = 206/996 (20%), Positives = 441/996 (44%), Gaps = 77/996 (7%)
Query: 1 MDPSGVKVLETAE----DIQERRQQVLDRYHRFKELSTLRRQKLED--SYRFQFFQRDAE 54
M+ +G ++LE + IQE+ Y + KE R L++ S QF + +
Sbjct: 4089 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4148
Query: 55 ELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD----------E 104
LE E++ E + P ++ +++K + ++ N V ++ +
Sbjct: 4149 ILESL--ERIV----ERLRQPPSISAEVEK---IKEQISENKNVSVDMEKLQPLYETLKQ 4199
Query: 105 TGNLMISEG-----HFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ------ 153
G MI+ +++ ++ +L ++ WE + + E+ KLL +L +
Sbjct: 4200 RGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4259
Query: 154 --YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
+ +D D+I D E + G D V+ Q+ E + ++ +E ++ V
Sbjct: 4260 MSLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4313
Query: 212 AAKLIQE-QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETIS 269
++LI P++ ++K DE+N+AW L R KL A + ++ +
Sbjct: 4314 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4373
Query: 270 WIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLS 328
W+ +AS G DL +V+ + + + + + + +++ L +A+ L +
Sbjct: 4374 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4433
Query: 329 ATQ--IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALIN 385
+ + +Q EL W+ + R +L + L +F +L +W+T + L++
Sbjct: 4434 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4493
Query: 386 ADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASDEVREKL 442
+ + D E L +H + ++ AH+ + ++ +++G L+ +AG AS+ ++ KL
Sbjct: 4494 EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN-LQNKL 4552
Query: 443 TVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLL-NEDLGDSLD 500
VL++ +LE E R+QQ + + + F+ + E + W++ E LL ++ LG +
Sbjct: 4553 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4612
Query: 501 SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAME-DVATRRDALLSRRNALH 559
+ + L H + + A+EE +L + +++ + E ++ + L + ++
Sbjct: 4613 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4672
Query: 560 ERAMRRRAQLADSFHLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQG----KVQKH 614
+ R+ +L ++ +L F +S + +W+ + +T PS + ++ +H
Sbjct: 4673 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN--VASRPSLILDTVLFQIDEH 4730
Query: 615 QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISL---WKKLLEATELKG 671
+ F E+++++ +I L+K G L + K +V N +IS+ W+K+++ +G
Sbjct: 4731 KVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERG 4788
Query: 672 IKLREANQQ-QQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNLQKKHALLEADVAA 729
L +A ++ +QF+ + WL E E L S+ + D ++ +H + + A
Sbjct: 4789 RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA 4848
Query: 730 HQDRIDGITIQARQFQDAGHFDAENIKKKQ--EALVARYEALKEPMVARKQKLADSLRLQ 787
D R ++ +N+K L +++ + V R+ KL ++L
Sbjct: 4849 KHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4908
Query: 788 QLFRD-VEDEETWIREKEP-IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
F D ++ W+ EP +A D+ V NL+ H+A Q E+ ++A+ +
Sbjct: 4909 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4968
Query: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAES 904
++E + VK ++ EL+ +WE + A + ++ LE +L QA+++ + +
Sbjct: 4969 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 5028
Query: 905 WMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDL 939
W+ E E + DED+ L+ +H+ M L
Sbjct: 5029 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL 5064
Score = 160 bits (405), Expect = 1e-38
Identities = 484/2522 (19%), Positives = 976/2522 (38%), Gaps = 424/2522 (16%)
Query: 9 LETAEDIQERRQQVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA 67
++ E Q + Q+ ++ K L+T L +QK+ S + Q +E +K+ ++
Sbjct: 1484 IQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVS-EIEMKQSKMDECQKYAEQYSATV 1540
Query: 68 SDENYKDPTN--LQGKLQKHQAFEAEVQANSGAIV--------KLDETGNLMISEGHFAS 117
D + T + QK +Q+++ I+ + LM FA
Sbjct: 1541 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1600
Query: 118 ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLV----QYLRECEDV------MDWIND 167
++++ L + + L E+ +E K + QK V + L++ E I+
Sbjct: 1601 DSLK----RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1656
Query: 168 KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE---------ERVNEVNQFAAKLIQE 218
+E E+L + L+ +++ K + TD +E E N + + K +QE
Sbjct: 1657 EEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1716
Query: 219 QHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
EE+++ +Q E Q + L Q + +L G E E +
Sbjct: 1717 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1776
Query: 273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
++E+L D G A + + L+ + L + KAL + +L ++ + Q+
Sbjct: 1777 KQEELQ-KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ--KLNEAK-IKCEQL 1832
Query: 333 QVKREELITNWEQIRTLAA-ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELAS 391
+K E+ +++ T A E ++ +L+ +L W++ N D+ S
Sbjct: 1833 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DS 1885
Query: 392 DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
+ AG + HK I+ + F+ D G++ + DEV L + ++
Sbjct: 1886 ERAGTK--------HKQVIEQNGTHFQEGD--GKSAIGE----EDEVNGNL-LETDVDGQ 1930
Query: 452 LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
+ E QQY++ Q + +S+ +A ++ + S + LL+K
Sbjct: 1931 VGTTQENLNQQYQKVK---------AQHEKIISQHQAVII------ATQSAQVLLEKQGQ 1975
Query: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
+ LS +E++ KL +N M+++ + L+ E+ M+ L +
Sbjct: 1976 Y---LSPEEKE---------KLQKN----MKELKVHYETALAES----EKKMKLTHSLQE 2015
Query: 572 SFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSN-LQGKVQKHQAFEAELSANQSRID 629
L++F D E + W+ + + + EA D N L K+++ ++F ++ +++ +
Sbjct: 2016 E--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 2073
Query: 630 ALEKAGQKLIDVNHYAKD-------------EVAARMNEVISLWKKLLEATELKGIKLRE 676
+ +G ++++ EV +++ ++ L + G L++
Sbjct: 2074 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 2133
Query: 677 ANQQQQFNRNVE-----DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+ Q + ++ HL S+ D N+Q ++ L+ +++ Q
Sbjct: 2134 LVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQ 2192
Query: 732 DRIDGITIQARQFQDA--GHFDAEN-IKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
++ + A DA A+N I+K + +V RYE L + + R +KL +L
Sbjct: 2193 VAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2252
Query: 789 LFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
+D DE E+ ++E+ + ++ +Q+++ K+ L+ +IAG + I
Sbjct: 2253 SVQDGLDEMLDWMGNVESSLKEQGQVPLNST------ALQDIISKNIMLEQDIAGRQSSI 2306
Query: 841 KAVTQKGNAMVEEGH-FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA 899
A+ +K +E A ++AK+ +L+ ++ K + +E+ + F +
Sbjct: 2307 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 2366
Query: 900 NEA-ESWMREKEPIVGSTDY-GKD---------EDSAEALL-KKH----EALMSDLSAYG 943
+E ++++ K + D GKD E ++E L KKH +L+ ++S++G
Sbjct: 2367 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 2426
Query: 944 -----------------------SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
+I+ +E SC++Q+ + + LV +L + +
Sbjct: 2427 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL-----DAFQVLVKSLKSWIK 2481
Query: 981 KSPREVTMKKG-----DILTLLNSTNK--DWWKVEVNDRQ-----GFVPAAYVKKLD-PA 1027
++ ++V + + D+ L T K + W ++ + Q G + + PA
Sbjct: 2482 ETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPA 2541
Query: 1028 QSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGML 1087
++ + ++ G++ + N G S++ K + ++ H +LG K +
Sbjct: 2542 KAIAA---VKSGGAVLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI 2597
Query: 1088 EKSCKKFMLFREANE----LQQWINEKEAALTSEE---VGADLEQVEVLQKKFDDFQKDL 1140
+ K ++A E + QW+ + T + D E V+ ++ F+ +L
Sbjct: 2598 AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2657
Query: 1141 KANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
K N ++++++ +K+ E LE + D+ A WK
Sbjct: 2658 KQNVNKVQELKDKLTELLE-----------------------ENPDTPEAPRWKQM---- 2690
Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIEEKN----- 1253
+ E++ +W+ L QL +R Q L S++ + +F + K+W+ EK
Sbjct: 2691 --------LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2742
Query: 1254 --------QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPE 1305
LNT + + RK + +E+ AA ++ GE P
Sbjct: 2743 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQ-YEQLTAAGQGILSRPGED--------PS 2793
Query: 1306 SAEDLQEKCTELNQAWSSL----GKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
++E+ + Q W SL R D + S Q L D +S ++ L
Sbjct: 2794 LRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KL 2851
Query: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQL--LAHGHYASPEIKQK 1419
SS ++ LE Q+ + EI + + + L L Y E+ ++
Sbjct: 2852 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2911
Query: 1420 LDILDQERADLE-KAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK-GDSL 1477
L+ + + D+E KA + + C F + + W+ ++ N L
Sbjct: 2912 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2971
Query: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA-KGDISSRRNEVLDRWRRL 1536
D +E+LIK H+DF K + Q A + L+ + K + + N + W
Sbjct: 2972 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 3031
Query: 1537 KAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS------EKLQTASDESYKDPTNIQLSK 1589
Q+ E+ +KL ES + ++ V+ + WI E+++ D + + + +L
Sbjct: 3032 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 3091
Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLI--ERGACAGSEDAVKARLAALADQWQF 1647
L + +H L+ A+ + V ++ ++ E + D V +L + +
Sbjct: 3092 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3151
Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQ 1706
+ QK E + KE+ +Q D + L S+ Y K L + K Q
Sbjct: 3152 MTQKFKEFQEVSKESKRQLQCAKEQLD-------IHDSLGSQAYSNKYLTMLQTQQKSLQ 3204
Query: 1707 LLEADISAHEDRLKDLNSQA-DSLMTSSA-FDTSQVKDKRDTINGRFQKIKSMAASRRAK 1764
L+ + + +DL +A DS TS + + T++ Q++ + K
Sbjct: 3205 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS---QQVDEKCSFLETK 3261
Query: 1765 L-------NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ----NLRKKHKR 1813
L N + F + DDE L GRD +Q ++ K+
Sbjct: 3262 LQGIGHFQNTIREMFSQFAEFDDE---------LDSMAPVGRDAETLQKQKETIKAFLKK 3312
Query: 1814 LEAELAAHEPAIQGVLDTGKKL--SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1871
LEA +A+++ A + T K + +++ + I++ L + +L A AR +++
Sbjct: 3313 LEALMASNDNANK----TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3368
Query: 1872 EESLE-YQQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQGLLKKHEAFE-TDFTVHK 1928
E +++ ++F + ++E + + S+ G I L + F+ + +
Sbjct: 3369 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3428
Query: 1929 DRVNDVCTNGQDLIKK--NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
+ DV GQ LI+ + + + + +N + L K AQR A+L E A L
Sbjct: 3429 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE--ALLHC 3486
Query: 1987 NWKADVVE---SWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT 2042
D +E SW+ + E + + V+ + +Q+ LQ + + +
Sbjct: 3487 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL----LQRLLDDRKSTVE 3542
Query: 2043 ALK---DQLLAAKHVQSKAIEARHASLM-KRWSQLLANSAARKKKL----LEAQSHFRKV 2094
+K +++ K + SL+ RW LL + R ++L + AQ +
Sbjct: 3543 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3602
Query: 2095 EDL--FLTFAKKA---------------------SAFNSWFENAEEDLTDPVRCNSLEEI 2131
E L +LT +K A N + L V ++
Sbjct: 3603 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3662
Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
+ RE D +S L DF+Q+ ++ Q KS E L++ N KI
Sbjct: 3663 LSSREDKDMVQSKL-----DFSQVWYIEIQEKSHS---------RSELLQQALCN-AKIF 3707
Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT------ 2245
E E+EL E +DKL + Q + W Q++ +L ++ +
Sbjct: 3708 GEDEVELM--NWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3765
Query: 2246 ---------------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEH 2290
++ +LEA K ++++I + + D+ +E+AL L + H
Sbjct: 3766 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST------DVAKTLEQALQLARRL--H 3817
Query: 2291 ST 2292
ST
Sbjct: 3818 ST 3819
Score = 112 bits (281), Expect = 3e-24
Identities = 330/1819 (18%), Positives = 696/1819 (38%), Gaps = 265/1819 (14%)
Query: 669 LKGIKLREANQQQQFNRN-VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
LK L + +++ N V+D+ W+ E++ L ++G DL +V++ + H + +
Sbjct: 767 LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 826
Query: 728 AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
+ + I Q +K L ++Y L +++ L L
Sbjct: 827 EEFESSLKEAKISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQERHLDT---LH 880
Query: 788 QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
+E W+ EKE + + + + H L E+ E IK+V +
Sbjct: 881 NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIA 940
Query: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
++ E H A ++A + +W + Q ++++ ++F DA EA ++R
Sbjct: 941 EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 1000
Query: 908 EKEPIVG---STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
+ + S D E L+++ +L Y S+I L +A++ Q
Sbjct: 1001 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 1060
Query: 965 DETGKEL--VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV 1021
D K + A+ DY++ E+T+ K D L N++++ WKV + VP+
Sbjct: 1061 DCPLKTSIPIKAICDYRQ---IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCF 1117
Query: 1022 KKLDPAQSA-SRENLLEE--QGSIALRQEQIDNQTRIT------------KEAGSVSLRM 1066
P + A N +E+ Q + L E N + + + S++
Sbjct: 1118 TVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKT 1177
Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKK--------FMLFREANELQQWINEKEAALTSEE 1118
E L L + + LE S + L +E N +Q+ E + EE
Sbjct: 1178 MLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREE 1237
Query: 1119 ------------------------------VGADLEQVEVLQKKFD-DFQKDLKANESRL 1147
+ LE+ ++ + F Q+ LK RL
Sbjct: 1238 QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL 1297
Query: 1148 KD----INKVAEDLESEGLMAEEVQAVQQQ---------EVYGM----MPRDETDSKTAS 1190
KD I E+ S+ + V ++ + +VY M + + +T +
Sbjct: 1298 KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 1357
Query: 1191 PWKSARLMVH-----------TVATFNSIKEL---NERWRS--------LQQLAEERSQL 1228
++A +V +A N+I+ L ++WRS L +E +
Sbjct: 1358 NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 1417
Query: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
+ E+ + +++ D +W +EK L + + + + R EG + L D
Sbjct: 1418 KAISDEMFKTYKERDLDFDWHKEKADQL-VERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1476
Query: 1289 VNSLG------ETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD- 1340
+ L ET +R IQ + PE+++ L T+LNQ L + +++K+ +
Sbjct: 1477 YHPLDDWIQQVETTQRKIQENQPENSKTL---ATQLNQQ-KMLVSEIEMKQSKMDECQKY 1532
Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELA-----KDVTGAEALLERHQEHRTEIDARAGTF 1395
+++ + +D R +V S + + + + A+ +++ + RT A
Sbjct: 1533 AEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1592
Query: 1396 QAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF----- 1450
+ +F A +K+ L++E LE+ +++ +++ ELQ +
Sbjct: 1593 TQYIKF----------AGDSLKR----LEEEEKSLEE---EKKEHVEKAKELQKWVSNIS 1635
Query: 1451 --HRDCEQA------ENWMAAREAFLNTEDKGDSLDSVEALIKKHED--FDKAINVQEEK 1500
+D E+A + +++ E E ++L +++ + KH D D+ N E++
Sbjct: 1636 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1695
Query: 1501 IAALQAFADQLIAAG------HYAKGDISSRRNEVLDRWRRLKAQ-------MIEKRSKL 1547
+ LQ + L + GD+ V +R + K + + + ++L
Sbjct: 1696 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1755
Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASD---------ESYKDPTNI---------QLSK 1589
Q E++ + S++ + D E K+ N Q K
Sbjct: 1756 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1815
Query: 1590 LLSKHQKHQAFE--AELHANADRIRGVIDMG-----NSLIERGACAGSEDAVKARLAALA 1642
L + + ++A +L+ A++ + +D E+ A + K ++ L
Sbjct: 1816 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1875
Query: 1643 DQWQFLVQKSAEKS-QKLKEANKQQNFNTGIKDFDFWLSEVEA----LLASEDYGKDLAS 1697
D W V K +E++ K K+ +Q + D + E + LL ++ G+ +
Sbjct: 1876 D-WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1934
Query: 1698 VNNLLKKHQLLEAD----ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
NL +++Q ++A IS H+ + S L + + + K+K N + K
Sbjct: 1935 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK-NMKELK 1993
Query: 1754 IKSMAA----SRRAKLNES--HRLHQFFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQN 1806
+ A ++ KL S L +F D + E W+++ + + + + G D+ G+
Sbjct: 1994 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 2053
Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSD-------------DNTIGKEEIQQRLAQF 1853
K+ K ++ +H+ ++ + +G ++ + D + E+Q++L
Sbjct: 2054 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 2113
Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQF-------VANVEEEEAWINEKMTLVASEDYGD 1905
+ ++ L G L++ ++ YQ + +A ++ EA ++ + SE
Sbjct: 2114 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL----SEPIAV 2169
Query: 1906 TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH---HEENISSKMKGLNGK 1962
+Q L++ +A + + + V + + L+ + +I + + G+
Sbjct: 2170 DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR 2229
Query: 1963 VSDLEKAAAQRKAKLDEN-SAFLQFNWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLL 2020
DL K+ +R KL + L D + W+G E+SLK + +++Q ++
Sbjct: 2230 YEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDII 2289
Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
+K + + Q ++I A+ +++ + + + MK S + ++ +
Sbjct: 2290 SKNIMLEQDIAGRQ----SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2345
Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
K+ L + +LF ++K F A ++ P + ++ L +
Sbjct: 2346 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGK-----DVTELSQYMQE 2400
Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQK 2200
S + L L ++I S + S+ LE+T NL K KE E +++
Sbjct: 2401 STSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL-----VLEKT-NNLSKKFKEMEDTIKE 2454
Query: 2201 EQRRQEENDKLRQEFAQHANAFHQWIQET--RTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
++ + F + WI+ET + ++ S E+ G LE TK+ +
Sbjct: 2455 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLEDTKKLQE 2511
Query: 2259 EIRAMRSQLKKIEDLGAAM 2277
+ +++K+ + G ++
Sbjct: 2512 KWSLKTPEIQKVNNSGISL 2530
Score = 102 bits (255), Expect = 4e-21
Identities = 450/2452 (18%), Positives = 904/2452 (36%), Gaps = 352/2452 (14%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ--IASDENYKDPTNLQGKLQKHQA 87
K L+T R Q+ F R EL W+ EK + +A D + ++ TN+ K H
Sbjct: 864 KLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEEEVAYDWSERN-TNIARKKDYHAE 921
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQ 147
E+ I + E ++ E H A TI + QW +L+
Sbjct: 922 LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ----------L 971
Query: 148 AQKLVQYLRECEDVMDWIND-KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
Q + Q+++E ++ ND KEA L + +Q+K+ +R +
Sbjct: 972 CQCVEQHIKENTAYFEFFNDAKEATDYLRNL------KDAIQRKYS---------CDRSS 1016
Query: 207 EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK---LFGAAEVQRF--N 261
+++ + + +EEL++ K N + + L+ + L + ++
Sbjct: 1017 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 1076
Query: 262 RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL 321
R ++ TI K+ E ++A++ + E V ++C
Sbjct: 1077 RQIEITI--YKDDECVLANNSHRAKWKVISP------------TGNEAMVPSVCFTVPPP 1122
Query: 322 QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF-RDLTSWVTEM 380
+ A +I+ + + ++T W E H + + + R S V +
Sbjct: 1123 NKEAVDLANRIEQQYQNVLTLWH-------ESHINMKSVVSWHYLINEIDRIRASNVASI 1175
Query: 381 KALINADE---LASDVAGAEALLDRHQEHK----GEIDAHEDSFKSADESGQALLAAGHY 433
K ++ + L++ + E L+ QE + +I E + Q LL +
Sbjct: 1176 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1235
Query: 434 ASDEVREKLTVLSEERAALLELWELRRQQYEQCM------DL-QLFYRDTEQVDNWMSKQ 486
E +SE R L L + Q DL + +R TEQ K+
Sbjct: 1236 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE---KLKK 1292
Query: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
E L +DLG + K E+F S +A + L ++QN + +T
Sbjct: 1293 ELERLKDDLG-------TITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 1344
Query: 547 RRDAL----LSRRNALHERAM---------RRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
D L L +N A+ A +AD +++ + +S V+EK
Sbjct: 1345 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1404
Query: 594 K---TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKL-IDVNHYAKD-- 647
+ DE K + + ++ + + ++ + D L + Q + + +++ +D
Sbjct: 1405 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1464
Query: 648 ------EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHL 701
+ + W + +E T+ K I+ + + + ++ + E+E
Sbjct: 1465 GIGKSLKYYRDTYHPLDDWIQQVETTQRK-IQENQPENSKTLATQLNQQKMLVSEIEMKQ 1523
Query: 702 AS-DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQE 760
+ D+ K K + L A D ++ R+ Q + A+ I ++
Sbjct: 1524 SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS----ADLIIQEFM 1579
Query: 761 ALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGV 819
L RY AL M + DSL RL++ + +E+E +KE + + K + +
Sbjct: 1580 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-----KKEHVEKAKELQKWVSNI 1634
Query: 820 QNLLKKHQALQAEIAGHEP--RIKAVTQKGNAMVEEGHFAAEDVKAKL------------ 865
LK AE AG P + K +++ + E+ A + ++ L
Sbjct: 1635 SKTLK-----DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1689
Query: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE-----KEPIVGSTDYGK 920
+EL ++ + L+ + + LQ Q D E + E KE + G D
Sbjct: 1690 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLT 1749
Query: 921 DEDSAEALLKKHEALM-----SDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLAL 975
++ L+ EA M +L Y S + L++ Q Q +A E K L
Sbjct: 1750 QTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA----EVVKNTENFL 1803
Query: 976 YDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035
+ EK +E K I LN ++ + Q K+LD + + +
Sbjct: 1804 KENGEKLSQE---DKALIEQKLNEAKIKCEQLNLKAEQS------KKELDKVVTTA---I 1851
Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
EE +A ++ +++T+I +S K E G K K ++E++ F
Sbjct: 1852 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE-------RAGTKHKQVIEQNGTHF- 1903
Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK-DINKVA 1154
Q + K A +EV +L + +V + Q++L ++K K+
Sbjct: 1904 ---------QEGDGKSAIGEEDEVNGNLLETDV-DGQVGTTQENLNQQYQKVKAQHEKII 1953
Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
++ + + Q + +++ + P ++ + ++KEL
Sbjct: 1954 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ------------------KNMKELKVH 1995
Query: 1215 WRSLQQLAEERSQLLGS-AHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQ 1272
+ + +E++ +L S E+++F D E + W+++ Q L N + D+ +
Sbjct: 1996 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 2055
Query: 1273 RKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE-------------DLQEKCTELNQ 1319
++ + F D+ + + + + R++++ ++ ++Q K
Sbjct: 2056 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 2115
Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVS---SDELAKDVTGAE 1375
+ SL + + L D D + D L++ + S S+ +A D +
Sbjct: 2116 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2175
Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLL-AHGHY--ASPEIKQKLDILDQERADLEK 1432
LE + + +I ++ + ++ + LL A G A +I++ LD + DL K
Sbjct: 2176 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2235
Query: 1433 AWVQRRMMLDQCLELQLFHRD-CEQAENWMAAREAFLNTE-----DKGDSLDSVEALIKK 1486
+ +R L L L +D ++ +WM E+ L + + D + I
Sbjct: 2236 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2295
Query: 1487 HEDF---DKAINVQEEKIAALQAFADQLIAAGHYAK-GDISSRRNEVLDRWRRLKAQMIE 1542
+D +IN EK+ D A+ AK D+S+R +E + + A+M E
Sbjct: 2296 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2355
Query: 1543 KRSKLGESQTLQQFSRDVDEIEAWISEKLQ--TASDESYKDPTNIQ--LSKLLSKHQKHQ 1598
++K ++ F ++++ ++ K Q T D KD T + + + S+ +H+
Sbjct: 2356 LKTK------VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2409
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
LH+ I + V + L+ +++ + EK +
Sbjct: 2410 KHLEVLHSLLKE-----------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 2458
Query: 1659 LKEANKQQN-FNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLLKKHQLLEA 1710
+ +Q + F +K W+ E V+ +ED GK L L +K L
Sbjct: 2459 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2518
Query: 1711 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTING--------RFQKIKSMAASRR 1762
+I + L S +T+ A + VK +NG F K + + ++
Sbjct: 2519 EIQKVNNSGISL-CNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2577
Query: 1763 AKLNESHRLHQFFRDMDDEESWIKEK--KLLVGSEDYGRDLTGVQNLRK----------- 1809
+ SH + D+ + + K KL E+ + +Q + K
Sbjct: 2578 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2637
Query: 1810 -----------KHKRLEAELAAHEPAIQGVLDTGKKLSDDN--TIGKEEIQQRLAQFVEH 1856
++K EAEL + +Q + D +L ++N T +Q L +
Sbjct: 2638 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2697
Query: 1857 WKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL- 1914
W+EL QL R Q+LEES QF + + W+ EK +V+ L+ +L
Sbjct: 2698 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS---VLGPLSIDPNMLN 2754
Query: 1915 ---KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE----------NISSKMKGLNG 1961
++ + +F K + + GQ ++ + ++ K L G
Sbjct: 2755 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2814
Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
++SD Q K + + L + S K D LSS + T
Sbjct: 2815 QLSDRCDWIDQAIVKSTQYQSLL---------------RSLSDKLSDLDNKLSSSLAVST 2859
Query: 2022 KQETFDAGLQAFQQEGIANITALKDQLLAAKHV---QSKAIEARH--ASLMKRWSQLLAN 2076
+ + L+ Q+ I K Q+ A+ + S ++ + A L ++ +L +
Sbjct: 2860 HPDAMNQQLETAQKMK-QEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2918
Query: 2077 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE--NAEEDLTDPVRCNSLEEIKAL 2134
++K H + F + + F +W + E++ + P+ L+ +++L
Sbjct: 2919 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA-KLDVLESL 2977
Query: 2135 REAHDAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
+ H F +L++ + + +AE + + + + + ++ W K +KE
Sbjct: 2978 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 3037
Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLD-GSCMVEESGTLESQLEA 2252
RE +L +E+ + ++ + WI + + L + C+ G E+ +
Sbjct: 3038 RENKL-------KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG--ENSIAK 3088
Query: 2253 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQ 2304
K +E+ ++ + + ++ +D + L Q+ D + +
Sbjct: 3089 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 3140
Score = 70.1 bits (170), Expect = 3e-11
Identities = 87/439 (19%), Positives = 179/439 (40%), Gaps = 52/439 (11%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIASDENY 72
+ + ++ D++ S R+ KLE++ F DA + L W+ + Q+A D+
Sbjct: 4876 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4935
Query: 73 KDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
+L + H+AF+ E+ + ++ L + +I S ++ ++ EL +W
Sbjct: 4936 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4995
Query: 132 ELLLEKMREKGIKLLQAQKLVQYLRECED-------VMDWINDKEAIVTSEE-LGQDLEH 183
E + + + + +L LR+ E+ +++W+ + E + L D +
Sbjct: 4996 ETVC------ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 5049
Query: 184 VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEE-ELIKTKQDEVNAAWQRLKG 242
+ L + +EF + +N+ ++ HP+ IK + A ++ +
Sbjct: 5050 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 5109
Query: 243 LALQRQGKLFGAAEVQRFNRDVDETI-SWIKEKEQLMASDD---FGRDLASVQALLRKHE 298
A Q Q +L A +++ E + +W++ E + D +++ V+AL+ +H+
Sbjct: 5110 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5169
Query: 299 GLERDLAALE---DKV----KALCAEADRLQQSHPL--------------------SATQ 331
++ + DKV K A+ LQ P+ S TQ
Sbjct: 5170 TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQ 5229
Query: 332 IQVKREE---LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
I+ K L++ W+Q+ LA ER +LND+ L +F + + K + +
Sbjct: 5230 IETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNH 5289
Query: 389 LASDVAGAEALLDRHQEHK 407
S V +D+ Q+ K
Sbjct: 5290 KKSRVMDFFRRIDKDQDGK 5308
Score = 60.1 bits (144), Expect = 3e-08
Identities = 64/276 (23%), Positives = 114/276 (41%), Gaps = 12/276 (4%)
Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
+DL +WV EM+ ++ E SD+ E+ L+ H+ I+ E S K A S + A
Sbjct: 787 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 846
Query: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
EKL L + A LL R Q L F W++++E
Sbjct: 847 ---LKLTYAEKLHRLESQYAKLL---NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 900
Query: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
+ D + ++ H + + L +EE I ++ E A +L+ NH A + R A
Sbjct: 901 VAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 960
Query: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK-DPSN--- 606
+ ++ + + + + ++ +FF D+ E ++ +K A Y D S+
Sbjct: 961 MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL-RNLKDAIQRKYSCDRSSSIH 1019
Query: 607 -LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDV 641
L+ VQ+ + EL +S I L + +I +
Sbjct: 1020 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 1055
Score = 57.0 bits (136), Expect = 2e-07
Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 22/279 (7%)
Query: 145 LLQAQKLVQYLRECE-------DVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTD 197
LL++ L Q L E E D+++W+++ + + E G DL VE E +
Sbjct: 766 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE---SHLENHKNV 822
Query: 198 MAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 257
A EE + + + IQ P + K + + + +L + ++ L +
Sbjct: 823 HRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTL 879
Query: 258 QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAE 317
F + W+ EKE+ + D+ ++ H L R+L E+ +K++
Sbjct: 880 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 939
Query: 318 ADR-LQQSHPLSATQIQVKREELITNWEQIRTL--AAERHARLNDSYRLQRFLADFRDLT 374
A++ L ++HP T I+ R + T W I L E+H + N +Y F D ++ T
Sbjct: 940 AEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQCVEQHIKENTAY--FEFFNDAKEAT 996
Query: 375 SWVTEMKALIN---ADELASDVAGAEALLDRHQEHKGEI 410
++ +K I + + +S + E L+ E K E+
Sbjct: 997 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 1035
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 278 bits (711), Expect = 5e-74
Identities = 415/1966 (21%), Positives = 824/1966 (41%), Gaps = 178/1966 (9%)
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASET--IRTRLMELHRQ 130
+D LQ + + +AF +++A + ++T +M++ + + I+ L L +Q
Sbjct: 3116 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 3175
Query: 131 WELLLEKM--REKGIK--LLQAQKLVQYLRECEDVMDWINDKEAI-----VTSEELGQDL 181
LL++ RE+ ++ + + ++ L+E ++ + E + +E + Q L
Sbjct: 3176 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 3235
Query: 182 EHVEVLQKKFEEFQTDMAAHEERVNEVNQ----FAAKLIQEQHPEEELIKTKQDEVNAAW 237
+V QK EE + + ++ VN + Q AAK Q E +L D+VNA W
Sbjct: 3236 NMFKVFQK--EEIEP-LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL-----DDVNARW 3287
Query: 238 QRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLR 295
+ L QR +L A RF ++ +SW+ + E+L+A+ + V+A ++
Sbjct: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3347
Query: 296 KHEGLERDLAALEDKVKALCAEADRLQQS-HPLSATQIQVKREELITNWEQIRTLAAERH 354
+ + L+R L + V+ + E +++ + P +I + L + WE + A R+
Sbjct: 3348 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3407
Query: 355 ARLND-SYRLQRFLADFRDLTSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDA 412
+L S Q+F L W+T + K L+N + + + + E + +H+ + +I
Sbjct: 3408 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3467
Query: 413 HEDSFKSADESGQAL-LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-DLQ 470
H A GQ+L + + D V+ KL + E R + +Q + + +
Sbjct: 3468 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3527
Query: 471 LFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLSAQEEKITAL 526
+F D ++ NW+++ L + D S E L K+ + E L ++ AL
Sbjct: 3528 IFGEDEVELMNWLNEVHDKLSKLSVQDY--STEGLWKQQSELRVLQEDILLRKQNVDQAL 3585
Query: 527 DEFATKLIQNNHYAMEDVATRRDALLSRRNALHE------RAMRRRAQLADSFHLQQFFR 580
L Q + + + +A+ +R + + + + + QLA H
Sbjct: 3586 LNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTH--- 3642
Query: 581 DSDELKSWVNE---KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
+EL +W+++ ++ + + K Q +++ + + E N++ +D+L +
Sbjct: 3643 --EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNEVSSA 3699
Query: 638 LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN--QQQQFNRNVEDIELWLY 695
L+++ + E +M + +L+ T + ++ +A + QQF++ + W+
Sbjct: 3700 LLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT 3759
Query: 696 EVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA-GHFD 751
E E L S +D T+ Q +K +E + H+D ID + + A +
Sbjct: 3760 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHKIMTACSEEE 3817
Query: 752 AENIKKKQEALVARYEALKEPMVARKQKL--ADSLRLQQLFRDVEDEETWIREKEPIAAS 809
+++KKK + ++ Y+ + + R +L A SL + Q + E+ W+ E + I +
Sbjct: 3818 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETYEELWPWLTETQSIISQ 3876
Query: 810 TNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
+ ++ ++H+ L+ IA H+P I + + G ++E ++ K
Sbjct: 3877 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA 3936
Query: 869 NQKWEALKAKASQRRQDLEDSLQAQQYFADANEA--ESWMREKEPIVGSTDYGKDEDSAE 926
+ + +K +R L++++ F D + ES R E + + + +
Sbjct: 3937 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 3996
Query: 927 ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ----EKS 982
+ +++ + D+ + L+++ + + TD + + V D E
Sbjct: 3997 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4056
Query: 983 PREVTMKKGDILTLLNSTNKDWWK-----VEVNDRQGFVPAAYVKKLDPA----QSASRE 1033
V ++ +L ++ K W V + D Q F+ +DP+ Q + E
Sbjct: 4057 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVS------LRMKQVEEL---YHSLLELGEKRK 1084
+ EE + QE++D + E + + K ++EL + SL + + R
Sbjct: 4117 TIREEIDGL---QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4173
Query: 1085 GMLEKSCKKFMLFREANE-LQQWINEKEAALTS-EEVGADLEQVEVLQKKFDDFQKDLKA 1142
LE++ + + +++ + + W++ L S +G DLE V+ ++ F+ +
Sbjct: 4174 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4233
Query: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
+ ++ +N AE L+ ++V +E+D HTV
Sbjct: 4234 QQIEMERLNHQAE------LLLKKVT-------------EESDK-------------HTV 4261
Query: 1203 ATFNSIKELNERWRSLQQ-LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN- 1260
+ + EL W SL++ + + +L G+ + +F DE W+ L+
Sbjct: 4262 Q--DPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4319
Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTELNQ 1319
G D +++ KH + D+ A V ++ + LI+S E A +LQ K LNQ
Sbjct: 4320 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4379
Query: 1320 AWSSLGKRADQRKAKL-GDSHDLQRFLSDFRDLMSWINGI-RGLVSSDELAKDVTGAEAL 1377
W ++ ++ +QRK +L G + F + DL W+ R L++S L A+
Sbjct: 4380 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4439
Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQ 1436
L H E +A+ T+++ Q GQQ+LA A I Q ++ L ++ +E +
Sbjct: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
Query: 1437 RRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAI 1494
R+ L++ L L + FH + NW+ E LN + LD+V I +H+ F +
Sbjct: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRN---EVLDRWRRLKAQMIEKRSKLGESQ 1551
N E+I L L K D+ +N V RW ++ +++E+ L +++
Sbjct: 4560 NSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4617
Query: 1552 T-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
+QF ++ W+ SEK + E DP I+ L++H++ Q H+
Sbjct: 4618 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ--LAQHKEFQKSLGAKHSVY 4675
Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK-QQN 1667
D G SL E+ + A + L+ L D+W + KS E+ KL+EA
Sbjct: 4676 DTTNRT---GRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4732
Query: 1668 FNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
F ++ WL VE LA + +G D+ V NL+ H+ + ++ ++ L
Sbjct: 4733 FTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4791
Query: 1726 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR--------LHQFFRD 1777
A L+ S D+S VK + ++ R++ + +++ S++ +L + R +H
Sbjct: 4792 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4851
Query: 1778 MDDEESWIKEKKLLVGSEDYGRDLTGV-QNLRKKHKRLEAELAAHEPAIQGVL-----DT 1831
+ + E ++ +L ED R L + KK + AEL VL D+
Sbjct: 4852 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 4911
Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA---ARGQRLEESLEYQQFVANVEEEE 1888
+ TI + ++ LA +H + L A A+ + LE L + Q
Sbjct: 4912 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQ--------- 4962
Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
W +T E + ++ L+ +H+ F + T + V+ V
Sbjct: 4963 -WAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5007
Score = 265 bits (676), Expect = 5e-70
Identities = 503/2529 (19%), Positives = 1024/2529 (40%), Gaps = 298/2529 (11%)
Query: 49 FQRDAEELEKWIQEKLQIASDENYKDPTN-----LQGKLQKHQAFEAEVQANSGAIVK-L 102
FQ+ + + + W+ K + ++N P + L+ ++ H+ F + A S K +
Sbjct: 2765 FQQMSRDFQAWLDTKKE---EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2821
Query: 103 DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA-QKLVQYLRECEDV 161
E NL++ ++ +L + W+ ++++E+ KL ++ +K ++Y + E +
Sbjct: 2822 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2881
Query: 162 MDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
WI+ + + + D E K + Q +M H V +N A L+
Sbjct: 2882 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2941
Query: 222 EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE-----KEQ 276
++E++ DE + Q++ + Q K F + + ++ E K KEQ
Sbjct: 2942 DKEVVT---DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQ 2998
Query: 277 LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
L D G S L + ++ L AL+ +V A RL Q + A+ +
Sbjct: 2999 LDIHDSLGSQAYS-NKYLTMLQTQQKSLQALKHQVDL----AKRLAQDLVVEASDSKGTS 3053
Query: 337 EELITNWEQIRTLAAERHARLNDSY---------RLQ---RFLADFRDLTSWVTEMKALI 384
+ L+ Q+ T+A E H+ L+ +LQ F R++ S E +
Sbjct: 3054 DVLL----QVETIAQE-HSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDEL 3108
Query: 385 NADELASDVAGAEALLDRHQEHKG---EIDAHEDSFKSADESGQALLAAGHYASDEV--R 439
D +A AE L + + K +++A S +A+++ + +LA + D V +
Sbjct: 3109 --DSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3166
Query: 440 EKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDTEQVDNWMSKQEAFLLNED-LGD 497
L LS++ LL+ + R +Q E + L+ FY ++ + K E ++ +G
Sbjct: 3167 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 3226
Query: 498 SLDSVEALLKKHEDFEKS----LSAQEEKITALDEFATKLIQNNHYAMEDVATRR----- 548
+++ L + F+K L +++ + L + LIQ+ A + +T+
Sbjct: 3227 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ---GLIQS---AAKSTSTQGLEHDL 3280
Query: 549 DALLSRRNALHERAMRRRAQLADSF-HLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN- 606
D + +R L+++ +R AQL ++ H +F + L SW+ + + ++ K PS
Sbjct: 3281 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ--KPPSAE 3338
Query: 607 ---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA-KDEVAARMNEVISLWKK 662
++ ++Q+ + + L +S ++ +++ G+K+ A K ++ +++ + S W+
Sbjct: 3339 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3398
Query: 663 LLEATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLAS-DDYGKDLTNVQNLQKKH 720
LL E + +L + QQF+ +E + WL +E L + + G + ++ +H
Sbjct: 3399 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3458
Query: 721 ALLEADVAAHQDRI-DGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
LE D+ H + ++I + D + ++ K + Y ++E +R +
Sbjct: 3459 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3518
Query: 780 LADSLRLQQLFRDVEDE-ETWIRE-KEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHE 837
L +L ++F + E E W+ E + ++ + + G+ + + LQ +I +
Sbjct: 3519 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3578
Query: 838 PRIKAVTQKGNAMVEEGHFAAEDV---KAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQ 893
+ G ++++ ++V + KL + +++ + ++ + LE +LQ A+
Sbjct: 3579 QNVDQALLNGLELLKQT--TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3636
Query: 894 QYFADANEAESWMR--EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
+ + E +W+ E E + T K E++++A ++ E L + + + +L E
Sbjct: 3637 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNE 3695
Query: 952 QAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVND 1011
S ++ P G E ++A + + L++ T KVE D
Sbjct: 3696 -VSSALLELVPWRAREGLEKMVA--------------EDNERYRLVSDTITQ--KVEEID 3738
Query: 1012 RQGFVPAAYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITK------------ 1057
+ + D S E L G I L Q+Q Q ++ K
Sbjct: 3739 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3798
Query: 1058 ------------------EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
E S+ ++ +V + Y ++ ++ +R LE++ F E
Sbjct: 3799 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3858
Query: 1100 A-NELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL 1157
EL W+ E ++ ++ A + E + Q++ ++ + ++ + +NK L
Sbjct: 3859 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3918
Query: 1158 ----ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNE 1213
EG +E + V +Y + D + VA +I + +
Sbjct: 3919 LELSPGEGFSIQE-KYVAADTLYSQIKED--------------VKKRAVALDEAISQSTQ 3963
Query: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
+ Q+ E +++ + + ++ KE I E N D+ +Q L
Sbjct: 3964 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK------NVSVDMEKLQPLYE 4017
Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
L G+++ + ++ I SA+ +Q+K ++ W ++ ++R+A
Sbjct: 4018 T-------LKQRGEEMIARSGGTDKDI-----SAKAVQDKLDQMVFIWENIHTLVEEREA 4065
Query: 1334 KLGDSHDL-QRFLSDFRDLMSWINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDAR 1391
KL D +L ++F D L+ I + + ++ D + + E + R EID
Sbjct: 4066 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 4125
Query: 1392 AGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
G +L+A G P +K+ +D L+ L KAW R L++ ++ +
Sbjct: 4126 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 4185
Query: 1451 HRDCEQAE-NWM-AAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508
++D QA +W+ A + G L++V+ I++ + F Q+ ++ L A
Sbjct: 4186 YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQA 4245
Query: 1509 DQLI--AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEA 1565
+ L+ K + E+ W L+ ++I ++ KL G L QF +DE+ A
Sbjct: 4246 ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 4305
Query: 1566 WIS--EKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1623
W++ E L + DP I++ KH + ++ A+ + V GN LIE
Sbjct: 4306 WLTHTEGLLSEQKPVGGDPKAIEIELA-----KHHVLQNDVLAHQSTVEAVNKAGNDLIE 4360
Query: 1624 RGACAGSEDA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSE 1681
+ AG E + ++ +L L +WQ +++K+ ++ Q+L A +Q + F+ I+D WL++
Sbjct: 4361 --SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4418
Query: 1682 VEA-LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDT-SQ 1739
E LLAS+ G + L H + A A E+ K L + ++ +
Sbjct: 4419 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4478
Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLH-QFFRDMDDEESWIK--EKKLLVGSED 1796
+ + + +++ +++ R+ KL E+ L +F + D +W+ E+ L V S
Sbjct: 4479 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4538
Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE---IQQRLAQF 1853
L V +HK E+ +H I + TG L + K++ I+ L
Sbjct: 4539 -SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISV 4595
Query: 1854 VEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQ 1911
W+++ Q RG+ L+++ + +QF + W+ E + SE + + I+
Sbjct: 4596 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4655
Query: 1912 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENIS--SKMKGLNGKVSDLEKA 1969
L +H+ F+ + G+ L +K + ++N+ + L K +
Sbjct: 4656 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4715
Query: 1970 AAQRKAKLDENSAFL-QFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTKQETF 2026
+ +R+ KL+E F QF + W+ E L D +G D+ V L+ + F
Sbjct: 4716 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAF 4774
Query: 2027 DAGLQAFQQEGIANITALKD---QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKK 2083
L + +++ ALK +L+ S ++ + L RW + A S +++ +
Sbjct: 4775 QKELG----KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4830
Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLT-DPVRCNSLEEIKALREAHDAFR 2142
L ++ R+ E+ F A W AE+ L V + + ++ L + H F
Sbjct: 4831 L---EAALRQAEE----FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4883
Query: 2143 SSLSSAQADFNQLAELDRQIKSFRVASNPYT---WFTM------EALEETWRNLQK---- 2189
L +A+ N+ + + + + T W T+ E L ++ Q+
Sbjct: 4884 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4943
Query: 2190 ----IIKERELELQKEQRRQEEN---DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEE 2242
I K+ LE + E DK ++ Q I E +T++ + M +
Sbjct: 4944 LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEE---MTRK 5000
Query: 2243 SGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVG-------- 2294
++ + KR+ + +++S + + D G A + + Y S
Sbjct: 5001 QPDVDKVTKTYKRRAADPSSLQSHIPVL-DKGRAGRKRFPASSLYPSGSQTQIETKNPRV 5059
Query: 2295 --LAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM---------------- 2336
L +W Q+ L + + L + E L+EF+
Sbjct: 5060 NLLVSKWQQVWLLALERRRKLNDALDRL-------EELREFANFDFDIWRKKYMRWMNHK 5112
Query: 2337 -------FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2389
F+ DKD+ G++ QEF + S + + E A+ D D + DG
Sbjct: 5113 KSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL-------EMSAVADIFDRDGDG 5165
Query: 2390 HVSLQEYMA 2398
++ E++A
Sbjct: 5166 YIDYYEFVA 5174
Score = 233 bits (594), Expect = 2e-60
Identities = 446/2453 (18%), Positives = 976/2453 (39%), Gaps = 266/2453 (10%)
Query: 21 QVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIAS--DENYKDPTN 77
++ ++ +L+ R+QKLE+S FQ +L++W+ EK + S DP
Sbjct: 2515 EIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2574
Query: 78 LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTRLMELHRQWELL 134
L + Q+ Q E +L G ++S E ++ +L + ++W+ L
Sbjct: 2575 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2634
Query: 135 LEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSEE-LGQDLEHVE 185
++ ++ +K Q Q L++ L + D+ + ++ A+ T + + Q LE +
Sbjct: 2635 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2694
Query: 186 VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNA---AWQRLKG 242
++++ ++ + + + +++ L++E++ + EL + + + + Q+ +
Sbjct: 2695 KMKQEIQQEKKQIKVAQALCEDLSA----LVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2750
Query: 243 LALQRQGKLFGAAEVQRFNRDVDETISWIK-EKEQLMASDDFGRDLASVQALLRKHEGLE 301
Q + + Q+ +RD +W+ +KE+ S L +++L++ H+
Sbjct: 2751 HVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2807
Query: 302 RDLAALEDKVKALCAEADRL---QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLN 358
+ L A + AE + L Q +A Q+Q+ + TNW+ ER +L
Sbjct: 2808 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT--IKTNWDTFNKQVKERENKLK 2865
Query: 359 DSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSF 417
+S + ++ L W+ + + + + D A E + + + + E+D H
Sbjct: 2866 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2925
Query: 418 KSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQ---CMD-LQLFY 473
+ + + +LL+ + V+++E +L++ ++ +Q C++ + +
Sbjct: 2926 ELLNNTANSLLSVCEIDKE-------VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 2978
Query: 474 RDTEQVDNWMSKQEAFLLNE-DLGDSLDSVEALLKKH----EDFEKSLSAQEEKITALDE 528
++ ++V +Q + D+ DSL S +A K+ + +KSL A + ++
Sbjct: 2979 KEFQEVSKESKRQLQCAKEQLDIHDSLGS-QAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3037
Query: 529 FATKLI--QNNHYAMEDVATRRDALLSRRNALHERAMRR----RAQLADSFHLQQFFRDS 582
A L+ ++ DV + + + + L ++ + +L H Q R+
Sbjct: 3038 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3097
Query: 583 DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVN 642
+ ++++ + +D LQ + + +AF +L A + D K + ++
Sbjct: 3098 FSQFAEFDDELDSMAPVG-RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATE 3156
Query: 643 HYAKDEVAARMN-EVISLW-KKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEG 699
+ D V + + E +S KLL+ + + ++ ++ ++F +++ + L + E
Sbjct: 3157 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3216
Query: 700 HLASDD-YGKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQF--QDAGHFDAENI 755
H S G + + Q L + ++ Q + + + A + +
Sbjct: 3217 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-VEDEETWIREKEPIAASTNR-G 813
+ + + AR++ L + + R +L ++L F+D +E +W+ + E + A+
Sbjct: 3277 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS 3336
Query: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQK 871
+ V+ +++ + LQ + + ++ + ++G + A+ VK +L L+ +
Sbjct: 3337 AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSR 3395
Query: 872 WEALKAKASQRRQDLED-SLQAQQYFADANEAESWMREKEP-IVGSTDYGKDEDSAEALL 929
WEAL KA R + LE S+ AQQ+ W+ E +V G E +
Sbjct: 3396 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3455
Query: 930 KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMK 989
+H+AL D+ + + QA S Q + K++V + D+ + E+ K
Sbjct: 3456 AQHKALEDDIINHNKHLH----QAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3511
Query: 990 KGDILTLLNST-------NKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
LL +D W EV+D+ + KL Q S E L +
Sbjct: 3512 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK--------LSKLS-VQDYSTEGLWK 3562
Query: 1038 EQGS-------IALRQEQID----NQTRITKEAGS-----VSLRMKQVEELYHSLLELGE 1081
+Q I LR++ +D N + K+ + +++ ++ Y + +L
Sbjct: 3563 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3622
Query: 1082 KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV----GADLEQVEVLQKKFDDF 1136
LE++ + +E L W+++ E L S E G + Q ++ K +
Sbjct: 3623 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK---EL 3679
Query: 1137 QKDLKANESRLKDINK--------------------VAEDLESEGLMAEEV-QAVQQQEV 1175
+K+ K N++ L +N+ VAED E L+++ + Q V++ +
Sbjct: 3680 KKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDA 3739
Query: 1176 YGMMPRD-------------ETDSKTAS--------PWKSARLMV--------------- 1199
+ + ET+ K S SA+L V
Sbjct: 3740 AILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3799
Query: 1200 -------HTVATFNSIKELNERWRSLQQL-----------AEERSQLLGSAHEVQRFHRD 1241
H + T S +E + L ++ +E QL + V +F
Sbjct: 3800 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3859
Query: 1242 ADETKEWIEEKNQALNT-DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI 1300
+E W+ E ++ + +++ Q +H +A ++ + +T +L+
Sbjct: 3860 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3919
Query: 1301 QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRD--LMSWINGI 1358
+ P +QEK + +S + + +R L ++ D D L S +
Sbjct: 3920 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 3979
Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
L ++ +V + + ++ +++ ++ +Q G++++A +I
Sbjct: 3980 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4039
Query: 1419 KL--DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN-WMAAREAFLNTEDKGD 1475
K D LDQ + W ++++ E +L E AE W + +D D
Sbjct: 4040 KAVQDKLDQ----MVFIWENIHTLVEE-REAKLLDV-MELAEKFWCDHMSLIVTIKDTQD 4093
Query: 1476 SLDSVE------ALIKKHEDFDKAIN-----VQEEKIAALQAFADQLIAAGHYAKGDISS 1524
+ +E +++K+ ++ + I +QEE + ++ + A G K +
Sbjct: 4094 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4153
Query: 1525 RRNEVLDRWRRLKAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS---EKLQTASDESYK 1580
+E+ W L ++ KL E+ Q Q+ + + W+ KL + S
Sbjct: 4154 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----- 4208
Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
P L + + ++ + F++E + + + L+++ + V+ L
Sbjct: 4209 -PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 4267
Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQN-FNTGIKDFDFWLSEVEALLASED-YGKDLASV 1698
L W L ++ + KL+ A F + + WL+ E LL+ + G D ++
Sbjct: 4268 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGRFQKIKSM 1757
L KH +L+ D+ AH+ ++ +N + L+ SSA + S +++K + +N R+Q +
Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4387
Query: 1758 AASRRAKLNESHRLHQFFR-DMDDEESWIK--EKKLLVGSEDYGRDLTGVQNLRKKHKRL 1814
R+ +L+ + R + F +++D + W+ E+ LL G T + L H +
Sbjct: 4388 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV-HMEV 4446
Query: 1815 EAELAAHEPAIQGVLDTGKK-LSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
A A E + ++ G++ L+ + I Q + E W+ ++ R +LEE
Sbjct: 4447 CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4506
Query: 1874 SLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931
+L +F ++++ W+ + + TL + L + + +H+ F + H++++
Sbjct: 4507 ALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQI 4566
Query: 1932 NDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWK 1989
++ G L + + I + + + + + + +R LD+ QF+
Sbjct: 4567 IELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEA 4626
Query: 1990 ADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT-----A 2043
+ W+ E E SL ++ + D ++T L + + F L A + + + T +
Sbjct: 4627 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA--KHSVYDTTNRTGRS 4684
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
LK++ A + ++ + L +W + S R+ KL EA + D
Sbjct: 4685 LKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL----- 4737
Query: 2104 KASAFNSWFENAEEDLTD--PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
A W E L + PV ++ + L + H AF+ L + L R+
Sbjct: 4738 --QALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANA 2221
+ + + M+ L W + + ++ L+ R+ EE F +A
Sbjct: 4795 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEE-------FHSVVHA 4847
Query: 2222 FHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
+W+ E L + ++ L + ++ K +++ R++L K +G
Sbjct: 4848 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMG 4900
Score = 226 bits (576), Expect = 2e-58
Identities = 433/2280 (18%), Positives = 920/2280 (40%), Gaps = 246/2280 (10%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF-FQRDAEELEKWIQEKLQIASDENY- 72
+Q + + + F + R KL++S ++ E L WI + + +
Sbjct: 2839 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2898
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
DP + + K ++ + E+ + G + L+ T N ++S E + L ++ +
Sbjct: 2899 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2958
Query: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND-----KEAIVTSEELGQDL---EHV 184
++ E++ K L + + Q +E ++V KE + + LG +++
Sbjct: 2959 MVTEQLHSKKFCL---ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3015
Query: 185 EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL------IKTKQDEVNAAWQ 238
+LQ + Q + A + +V+ + A L+ E + ++T E + Q
Sbjct: 3016 TMLQTQ----QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3071
Query: 239 RLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ------- 291
++ + KL G Q R++ + ++ MA GRD ++Q
Sbjct: 3072 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP--VGRDAETLQKQKETIK 3129
Query: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR--EELITNWEQIRTL 349
A L+K E L A D C +++ P + +KR E L ++
Sbjct: 3130 AFLKKLEAL----MASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDR 3182
Query: 350 AAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEH-- 406
A R ++ + RL+ F + ++ + + + + E + G E Q +
Sbjct: 3183 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE----HEESQGPVGMETETINQQLNMF 3238
Query: 407 ----KGEIDAHEDSFKSADESGQALLAAGHYAS---------DEVREKLTVLSEERAALL 453
K EI+ + + + GQ L+ + ++ D+V + L+++ A
Sbjct: 3239 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA--- 3295
Query: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS-LDSVEALLKKHEDF 512
+ Q E + F E + +WM E + N+ + V+A +++ +
Sbjct: 3296 ---QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL 3352
Query: 513 EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-SRRNALHERAMRRRAQLAD 571
++ L ++ + + K+ A + ++ +LL SR AL +A R QL
Sbjct: 3353 QRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3412
Query: 572 -SFHLQQFFRDSDELKSWVN--EKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
S QQF + L W+ EK + S L+ ++ +H+A E ++ + +
Sbjct: 3413 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3472
Query: 629 DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV- 687
GQ L ++ ++ + +W +E E K E QQ N +
Sbjct: 3473 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW--YIEIQE-KSHSRSELLQQALCNAKIF 3529
Query: 688 --EDIEL--WLYEVEGHLAS---DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
+++EL WL EV L+ DY + + Q + +L+ D+ + +D +
Sbjct: 3530 GEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELRVLQEDILLRKQNVDQALLN 3587
Query: 741 ARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEE- 797
+ Q G + I+ K EA+ ARY+ + + + L +L+L + +E
Sbjct: 3588 GLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3646
Query: 798 TWIR--EKEPIAASTN--RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
TW+ E E ++ T +G++ Q K+ L+ E ++ + ++ + +A++E
Sbjct: 3647 TWLDKVEVELLSYETQVLKGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLEL 3703
Query: 854 GHFAA-EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE-SWMREKEP 911
+ A E ++ + E N+++ + +Q+ ++++ ++ Q F A +AE SW+ E E
Sbjct: 3704 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3763
Query: 912 ---IVGSTDYGKDEDSAEALLKK--------HEALMSDLSAYGSSIQAL--REQAQSCRQ 958
+G +D+ SA+ ++K H+ ++ DL G I E+ QS ++
Sbjct: 3764 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3823
Query: 959 QVAPTDDETGKELVLALYDY--QEKSPREVTMKKGDILTLLNSTNKDW--------WKVE 1008
++ + VL YD Q S R + +++ L N+ W W E
Sbjct: 3824 KL---------DKVLKNYDTICQINSERYLQLERAQSLV-----NQFWETYEELWPWLTE 3869
Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITK--------EAG 1060
+PA ++ Q L E IA + ID + E
Sbjct: 3870 TQSIISQLPAPALEYETLRQQQEEHRQLREL--IAEHKPHIDKMNKTGPQLLELSPGEGF 3927
Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVG 1120
S+ + + LY + E +KR L+++ + F + ++ Q + + E +
Sbjct: 3928 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILE------SLERIV 3979
Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQ---QQEVYG 1177
L Q + + + ++ + N++ D+ K+ E+ EE+ A +++
Sbjct: 3980 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4039
Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAE----ERSQLLGSAH 1233
+D+ D W++ +HT+ ++E + + +LAE + L+ +
Sbjct: 4040 KAVQDKLDQMVFI-WEN----IHTL-----VEEREAKLLDVMELAEKFWCDHMSLIVTIK 4089
Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
+ Q F RD ++ G D + V+ Q E ++ L ++++ +
Sbjct: 4090 DTQDFIRDLEDP----------------GIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4133
Query: 1294 ETAERLIQSHPESAEDLQEKCT-ELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
LI + E + + +K ELN AW SL K R KL ++ ++ + +
Sbjct: 4134 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4193
Query: 1352 MSWINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
W++ G L S + D+ + +E ++ ++E + + + LL
Sbjct: 4194 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4253
Query: 1411 YASPE--IKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAF 1467
S + ++ L L LE+ + R+ L+ L L F ++ W+ E
Sbjct: 4254 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4313
Query: 1468 LNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
L+ + G ++E + KH + + + A+ + LI + + +
Sbjct: 4314 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4373
Query: 1527 NEVLD-RWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEAWISE--------KLQTASD 1576
EVL+ RW+ + + +++ +L G + + F ++++++ W+++ K
Sbjct: 4374 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4433
Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS-EDAVK 1635
E+ K+ N+ H A A + + ++ G ++ R C S E +
Sbjct: 4434 ETAKEQLNV-----------HMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNID 4480
Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALL-ASEDYGK 1693
+ L ++W+ + K E+ KL+EA N F+ ++DF WL++ E L +
Sbjct: 4481 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSL 4540
Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQ 1752
L +V + +H++ ++++H +++ +L+ L S D +K+ ++ R++
Sbjct: 4541 ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWE 4600
Query: 1753 KIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTGVQNLRKK 1810
K+ R L+++ R QF W++E + + SE + D ++ +
Sbjct: 4601 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4660
Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ--QRLAQFVEHWKELKQLAAARG 1868
HK + L A TG+ L + ++ + ++ L++ + W + + R
Sbjct: 4661 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4720
Query: 1869 QRLEESLEYQ-QFVANVEEEEAWINEKMTLVASED--YGDTLAAIQGLLKKHEAFETDFT 1925
+LEE+L + QF ++ W+ +A + +GD + + L+ H+AF+ +
Sbjct: 4721 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELG 4779
Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ 1985
V + + ++LI+ + + +M+ L+ + + + ++ +L+ +A Q
Sbjct: 4780 KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLE--AALRQ 4837
Query: 1986 FNWKADVVES---WIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
VV + W+ E E +L+ D +++TL+ + + F L+ + E +
Sbjct: 4838 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAE-LNKA 4896
Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMK-RWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
T + D +LA H S ++++ R+ ++LA + +++L A + ++L
Sbjct: 4897 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL-- 4954
Query: 2101 FAKKASAFNSWFENAEEDLTDP---VRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
A +W + AE LTD V +EE+KAL H F ++ Q D +++ +
Sbjct: 4955 -----EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5009
Score = 188 bits (477), Expect = 6e-47
Identities = 502/2586 (19%), Positives = 1010/2586 (39%), Gaps = 326/2586 (12%)
Query: 14 DIQERRQ---QVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEEL-EKWIQEKLQIAS 68
++ E+RQ + D + K +S + + E F + + A++L E+W +QI
Sbjct: 1221 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI-- 1278
Query: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
D +D L+G + + + I +++ T + S+T+ T+L
Sbjct: 1279 DNRLRD---LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---- 1331
Query: 129 RQWELLLEKMREKGIKLLQAQKLV-QYLRECEDVMDWINDKEAIVTSEELG-----QDLE 182
Q ++L+ ++ K K+ + QK QY +D A+V S++ +
Sbjct: 1332 NQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQS 1391
Query: 183 HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE-LIKTKQDEVNAAWQRLK 241
+++ ++F + +T A + + +FA ++ EE+ L + K++ V A + K
Sbjct: 1392 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1451
Query: 242 GLA-LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH--- 297
++ + + K A F++ + +KEQL + L ++Q L KH
Sbjct: 1452 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEA------LQTIQLFLAKHGDK 1505
Query: 298 ------EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
LE+ + L++ L +E+ + Q S T VK EE I A
Sbjct: 1506 MTDEERNELEKQVKTLQESYNLLFSESLKQLQE---SQTSGDVKVEEKIV---------A 1553
Query: 352 ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
ER Q + + + +T+ + + + A + L ++Q + E+
Sbjct: 1554 ERQ---------QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1604
Query: 412 AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
K S QAL + ++E LS+E AL+E + + +C L L
Sbjct: 1605 ------KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKIKCEQLNL 1656
Query: 472 FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
EQ SK+E LD V K E + + Q E+ E
Sbjct: 1657 ---KAEQ-----SKKE-----------LDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1697
Query: 532 KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
+ N E T+ ++ + N H + ++ + + + ++D + V
Sbjct: 1698 DWLSNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGEEDEVNGNLLETD-VDGQVGT 1755
Query: 592 KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA 651
+ + K + + + +HQA + A QS LEK GQ L + K+++
Sbjct: 1756 TQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYL---SPEEKEKLQK 1809
Query: 652 RMNEVISLWKKLLEATELKGIKLREANQQQ--QFNRNVEDIELWLYEVEGHLASDDYGKD 709
M E+ ++ L +E K +KL + Q++ +F+ + + E WL + E L + + G D
Sbjct: 1810 NMKELKVHYETALAESEKK-MKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1868
Query: 710 -LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF---------QDAGHFDAE----NI 755
+ + K+ DV +H+ + ITI + +D G D +
Sbjct: 1869 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1928
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED---------EETWIRE-KEP 805
++K + R+ +L L D + Q + D E T + EP
Sbjct: 1929 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 1988
Query: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGHF--AAEDVK 862
IA D +Q L++ +ALQ +I+ + ++ + + +++ G A D++
Sbjct: 1989 IAV------DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2042
Query: 863 AKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA-NEAESWMREKEPIVGSTDYGKD 921
L ++ ++E L ++R + L+ +L D +E WM E +
Sbjct: 2043 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2102
Query: 922 EDSA-EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
+A + ++ K+ L D++ SSI A+ E+ + + TD T L + D
Sbjct: 2103 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET---TDPSTASSLQAKMKDLSA 2159
Query: 981 KSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG 1040
+ E + K + L + KVE+ + +KL + L E
Sbjct: 2160 RFS-EASHKHKETLAKMEELKT---KVELFENLS-------EKLQTFLETKTQALTE--- 2205
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE------LGEKRKGMLEKSCKKF 1094
+ + + + ++ +E+ S L K+ E+ HSLL+ L + +LEK+
Sbjct: 2206 -VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNN-- 2262
Query: 1095 MLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK------ 1148
L ++ E++ I EK+ A+TS + L+ +VL K + K+ ++
Sbjct: 2263 -LSKKFKEMEDTIKEKKEAVTSCQ--EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2319
Query: 1149 DINKVAEDL----ESEGLMAEEVQAVQQQEVY--GMMPRDETDSKTASPWKSARLMVHTV 1202
D+ K ED E L E+Q V + ++ T +K + KS +++
Sbjct: 2320 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2379
Query: 1203 ATFNSIKEL--NERWRSLQQ---------------LAEERSQLLGSAHEVQRFHRDADET 1245
T + +E N+ S+++ L ++ ++L ++Q+ ++
Sbjct: 2380 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2439
Query: 1246 KEWIEEKNQALNTDNYGH---DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
+W+++ N+ D +V+ +++ FE +L +KV L + L++
Sbjct: 2440 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2499
Query: 1303 HPESAEDLQEK--CTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIR 1359
+P++ E + K TE++ W L + R+ KL +S ++L +F + L W+
Sbjct: 2500 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2559
Query: 1360 GLVSS-DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
+VS L+ D ++ Q E R ++ GQ +L+ P ++
Sbjct: 2560 LMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG-EDPSLR- 2617
Query: 1419 KLDILDQERADLEKAWVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK--GD 1475
I+ ++ A + + W L D+C + Q ++ + + L+ D
Sbjct: 2618 --GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2675
Query: 1476 SL------DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAA--GHYAKGDISSRRN 1527
SL D++ ++ + + I ++++I QA + L A Y K ++S +
Sbjct: 2676 SLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLE 2735
Query: 1528 EVLDRWRRLKAQ----MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
+L ++ ++ + + +S S QQ SRD +AW+ K + +++ P
Sbjct: 2736 GILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD---FQAWLDTKKE---EQNKSHPI 2789
Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA-VKARLAALA 1642
+ +L L S + H+ F L A + I G +L+ + GSE A ++ +L +
Sbjct: 2790 SAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEKAALQLQLNTIK 2847
Query: 1643 DQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
W ++ E+ KLKE+ K + ++ W+ + + L + D A N
Sbjct: 2848 TNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENS 2907
Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
+ K + L+ ++ H ++ LN+ A+SL++ D V D+ ++ + + S+
Sbjct: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967
Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG-RDLTGVQNLRKKHKRLEAELAA 1820
+ L + + F+++ E +++L E D G Q K+ +
Sbjct: 2968 KFCLENMTQKFKEFQEVSKES----KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK 3023
Query: 1821 HEPAIQGVLDTGKKLSDDNTI------GKEEIQQRLAQFVEHWKELKQLAAARGQRLEES 1874
A++ +D K+L+ D + G ++ ++ + L Q + LE
Sbjct: 3024 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3083
Query: 1875 LE----YQQFVANVEEEEAWINEKMTLVA-----SEDYGDTLAAIQGLLKKHEAFETDFT 1925
L+ +Q + + + A ++++ +A +E I+ LKK EA
Sbjct: 3084 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS-- 3141
Query: 1926 VHKDRVNDVCT-------NGQDLI----------KKNNHHEENISSKMKGLNGKVSDLEK 1968
D N C DL+ K+ N + ++ + + G + LE+
Sbjct: 3142 --NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE 3199
Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
+ KL E S LQ KA+ E G ++T+ + L+ + + K+E
Sbjct: 3200 FYS----KLKEFSILLQ---KAEEHEESQGPV--GMETETINQQLNMFK-VFQKEEI--E 3247
Query: 2029 GLQAFQQEGIANITALKDQLL--AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE 2086
LQ QQ+ + L L+ AAK ++ +E + RW L A R +L E
Sbjct: 3248 PLQGKQQD----VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3303
Query: 2087 AQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP--------VRCNSLEEIKALREAH 2138
A H + +D + SW + EE + + V ++E K L+
Sbjct: 3304 ALLHCGRFQDAL-------ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLL 3356
Query: 2139 DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELEL 2198
D +S++ + + ++A ++ + L+ W L + R +L
Sbjct: 3357 DDRKSTVEVIKREGEKIATTAEPADKVKILKQ------LSLLDSRWEALLNKAETRNRQL 3410
Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
E + Q+F + ++W+ L++ + ++ LE Q+ K
Sbjct: 3411 -------EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3463
Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQW-DQLDQLGMRMQHNLEQQI 2317
+I L + +G +++ ++K S + +Q W ++ + L+Q +
Sbjct: 3464 DIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQAL 3523
Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEF--------KSCLRSLGYDLPMVEE 2369
G E L M + + DK +L+ Q++ +S LR L D+ + ++
Sbjct: 3524 CNAKIFGEDEVEL----MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3579
Query: 2370 GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAF-RALSSEGKPY 2428
+ D + +Q+ + + +R + K S ++ +AL + +
Sbjct: 3580 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3639
Query: 2429 VTKEEL 2434
T EEL
Sbjct: 3640 STHEEL 3645
Score = 167 bits (423), Expect = 1e-40
Identities = 206/996 (20%), Positives = 441/996 (44%), Gaps = 77/996 (7%)
Query: 1 MDPSGVKVLETAE----DIQERRQQVLDRYHRFKELSTLRRQKLED--SYRFQFFQRDAE 54
M+ +G ++LE + IQE+ Y + KE R L++ S QF + +
Sbjct: 3911 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3970
Query: 55 ELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD----------E 104
LE E++ E + P ++ +++K + ++ N V ++ +
Sbjct: 3971 ILESL--ERIV----ERLRQPPSISAEVEK---IKEQISENKNVSVDMEKLQPLYETLKQ 4021
Query: 105 TGNLMISEG-----HFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ------ 153
G MI+ +++ ++ +L ++ WE + + E+ KLL +L +
Sbjct: 4022 RGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4081
Query: 154 --YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
+ +D D+I D E + G D V+ Q+ E + ++ +E ++ V
Sbjct: 4082 MSLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4135
Query: 212 AAKLIQE-QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETIS 269
++LI P++ ++K DE+N+AW L R KL A + ++ +
Sbjct: 4136 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4195
Query: 270 WIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLS 328
W+ +AS G DL +V+ + + + + + + +++ L +A+ L +
Sbjct: 4196 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4255
Query: 329 ATQ--IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALIN 385
+ + +Q EL W+ + R +L + L +F +L +W+T + L++
Sbjct: 4256 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4315
Query: 386 ADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASDEVREKL 442
+ + D E L +H + ++ AH+ + ++ +++G L+ +AG AS+ ++ KL
Sbjct: 4316 EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN-LQNKL 4374
Query: 443 TVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLL-NEDLGDSLD 500
VL++ +LE E R+QQ + + + F+ + E + W++ E LL ++ LG +
Sbjct: 4375 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4434
Query: 501 SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAME-DVATRRDALLSRRNALH 559
+ + L H + + A+EE +L + +++ + E ++ + L + ++
Sbjct: 4435 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4494
Query: 560 ERAMRRRAQLADSFHLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQG----KVQKH 614
+ R+ +L ++ +L F +S + +W+ + +T PS + ++ +H
Sbjct: 4495 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN--VASRPSLILDTVLFQIDEH 4552
Query: 615 QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISL---WKKLLEATELKG 671
+ F E+++++ +I L+K G L + K +V N +IS+ W+K+++ +G
Sbjct: 4553 KVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERG 4610
Query: 672 IKLREANQQ-QQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNLQKKHALLEADVAA 729
L +A ++ +QF+ + WL E E L S+ + D ++ +H + + A
Sbjct: 4611 RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA 4670
Query: 730 HQDRIDGITIQARQFQDAGHFDAENIKKKQ--EALVARYEALKEPMVARKQKLADSLRLQ 787
D R ++ +N+K L +++ + V R+ KL ++L
Sbjct: 4671 KHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4730
Query: 788 QLFRD-VEDEETWIREKEP-IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
F D ++ W+ EP +A D+ V NL+ H+A Q E+ ++A+ +
Sbjct: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
Query: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAES 904
++E + VK ++ EL+ +WE + A + ++ LE +L QA+++ + +
Sbjct: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850
Query: 905 WMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDL 939
W+ E E + DED+ L+ +H+ M L
Sbjct: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL 4886
Score = 160 bits (405), Expect = 1e-38
Identities = 484/2522 (19%), Positives = 976/2522 (38%), Gaps = 424/2522 (16%)
Query: 9 LETAEDIQERRQQVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA 67
++ E Q + Q+ ++ K L+T L +QK+ S + Q +E +K+ ++
Sbjct: 1306 IQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVS-EIEMKQSKMDECQKYAEQYSATV 1362
Query: 68 SDENYKDPTN--LQGKLQKHQAFEAEVQANSGAIV--------KLDETGNLMISEGHFAS 117
D + T + QK +Q+++ I+ + LM FA
Sbjct: 1363 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1422
Query: 118 ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLV----QYLRECEDV------MDWIND 167
++++ L + + L E+ +E K + QK V + L++ E I+
Sbjct: 1423 DSLK----RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1478
Query: 168 KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE---------ERVNEVNQFAAKLIQE 218
+E E+L + L+ +++ K + TD +E E N + + K +QE
Sbjct: 1479 EEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1538
Query: 219 QHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
EE+++ +Q E Q + L Q + +L G E E +
Sbjct: 1539 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1598
Query: 273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
++E+L D G A + + L+ + L + KAL + +L ++ + Q+
Sbjct: 1599 KQEELQ-KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ--KLNEAK-IKCEQL 1654
Query: 333 QVKREELITNWEQIRTLAA-ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELAS 391
+K E+ +++ T A E ++ +L+ +L W++ N D+ S
Sbjct: 1655 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DS 1707
Query: 392 DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
+ AG + HK I+ + F+ D G++ + DEV L + ++
Sbjct: 1708 ERAGTK--------HKQVIEQNGTHFQEGD--GKSAIGE----EDEVNGNL-LETDVDGQ 1752
Query: 452 LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
+ E QQY++ Q + +S+ +A ++ + S + LL+K
Sbjct: 1753 VGTTQENLNQQYQKVK---------AQHEKIISQHQAVII------ATQSAQVLLEKQGQ 1797
Query: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
+ LS +E++ KL +N M+++ + L+ E+ M+ L +
Sbjct: 1798 Y---LSPEEKE---------KLQKN----MKELKVHYETALAES----EKKMKLTHSLQE 1837
Query: 572 SFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSN-LQGKVQKHQAFEAELSANQSRID 629
L++F D E + W+ + + + EA D N L K+++ ++F ++ +++ +
Sbjct: 1838 E--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1895
Query: 630 ALEKAGQKLIDVNHYAKD-------------EVAARMNEVISLWKKLLEATELKGIKLRE 676
+ +G ++++ EV +++ ++ L + G L++
Sbjct: 1896 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1955
Query: 677 ANQQQQFNRNVE-----DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+ Q + ++ HL S+ D N+Q ++ L+ +++ Q
Sbjct: 1956 LVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQ 2014
Query: 732 DRIDGITIQARQFQDA--GHFDAEN-IKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
++ + A DA A+N I+K + +V RYE L + + R +KL +L
Sbjct: 2015 VAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2074
Query: 789 LFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
+D DE E+ ++E+ + ++ +Q+++ K+ L+ +IAG + I
Sbjct: 2075 SVQDGLDEMLDWMGNVESSLKEQGQVPLNST------ALQDIISKNIMLEQDIAGRQSSI 2128
Query: 841 KAVTQKGNAMVEEGH-FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA 899
A+ +K +E A ++AK+ +L+ ++ K + +E+ + F +
Sbjct: 2129 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 2188
Query: 900 NEA-ESWMREKEPIVGSTDY-GKD---------EDSAEALL-KKH----EALMSDLSAYG 943
+E ++++ K + D GKD E ++E L KKH +L+ ++S++G
Sbjct: 2189 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 2248
Query: 944 -----------------------SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
+I+ +E SC++Q+ + + LV +L + +
Sbjct: 2249 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL-----DAFQVLVKSLKSWIK 2303
Query: 981 KSPREVTMKKG-----DILTLLNSTNK--DWWKVEVNDRQ-----GFVPAAYVKKLD-PA 1027
++ ++V + + D+ L T K + W ++ + Q G + + PA
Sbjct: 2304 ETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPA 2363
Query: 1028 QSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGML 1087
++ + ++ G++ + N G S++ K + ++ H +LG K +
Sbjct: 2364 KAIAA---VKSGGAVLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI 2419
Query: 1088 EKSCKKFMLFREANE----LQQWINEKEAALTSEE---VGADLEQVEVLQKKFDDFQKDL 1140
+ K ++A E + QW+ + T + D E V+ ++ F+ +L
Sbjct: 2420 AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2479
Query: 1141 KANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
K N ++++++ +K+ E LE + D+ A WK
Sbjct: 2480 KQNVNKVQELKDKLTELLE-----------------------ENPDTPEAPRWKQM---- 2512
Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIEEKN----- 1253
+ E++ +W+ L QL +R Q L S++ + +F + K+W+ EK
Sbjct: 2513 --------LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2564
Query: 1254 --------QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPE 1305
LNT + + RK + +E+ AA ++ GE P
Sbjct: 2565 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQ-YEQLTAAGQGILSRPGED--------PS 2615
Query: 1306 SAEDLQEKCTELNQAWSSL----GKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
++E+ + Q W SL R D + S Q L D +S ++ L
Sbjct: 2616 LRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KL 2673
Query: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQL--LAHGHYASPEIKQK 1419
SS ++ LE Q+ + EI + + + L L Y E+ ++
Sbjct: 2674 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2733
Query: 1420 LDILDQERADLE-KAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK-GDSL 1477
L+ + + D+E KA + + C F + + W+ ++ N L
Sbjct: 2734 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2793
Query: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA-KGDISSRRNEVLDRWRRL 1536
D +E+LIK H+DF K + Q A + L+ + K + + N + W
Sbjct: 2794 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2853
Query: 1537 KAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS------EKLQTASDESYKDPTNIQLSK 1589
Q+ E+ +KL ES + ++ V+ + WI E+++ D + + + +L
Sbjct: 2854 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2913
Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLI--ERGACAGSEDAVKARLAALADQWQF 1647
L + +H L+ A+ + V ++ ++ E + D V +L + +
Sbjct: 2914 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 2973
Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQ 1706
+ QK E + KE+ +Q D + L S+ Y K L + K Q
Sbjct: 2974 MTQKFKEFQEVSKESKRQLQCAKEQLD-------IHDSLGSQAYSNKYLTMLQTQQKSLQ 3026
Query: 1707 LLEADISAHEDRLKDLNSQA-DSLMTSSA-FDTSQVKDKRDTINGRFQKIKSMAASRRAK 1764
L+ + + +DL +A DS TS + + T++ Q++ + K
Sbjct: 3027 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS---QQVDEKCSFLETK 3083
Query: 1765 L-------NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ----NLRKKHKR 1813
L N + F + DDE L GRD +Q ++ K+
Sbjct: 3084 LQGIGHFQNTIREMFSQFAEFDDE---------LDSMAPVGRDAETLQKQKETIKAFLKK 3134
Query: 1814 LEAELAAHEPAIQGVLDTGKKL--SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1871
LEA +A+++ A + T K + +++ + I++ L + +L A AR +++
Sbjct: 3135 LEALMASNDNANK----TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3190
Query: 1872 EESLE-YQQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQGLLKKHEAFE-TDFTVHK 1928
E +++ ++F + ++E + + S+ G I L + F+ + +
Sbjct: 3191 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3250
Query: 1929 DRVNDVCTNGQDLIKK--NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
+ DV GQ LI+ + + + + +N + L K AQR A+L E A L
Sbjct: 3251 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE--ALLHC 3308
Query: 1987 NWKADVVE---SWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT 2042
D +E SW+ + E + + V+ + +Q+ LQ + + +
Sbjct: 3309 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL----LQRLLDDRKSTVE 3364
Query: 2043 ALK---DQLLAAKHVQSKAIEARHASLM-KRWSQLLANSAARKKKL----LEAQSHFRKV 2094
+K +++ K + SL+ RW LL + R ++L + AQ +
Sbjct: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3424
Query: 2095 EDL--FLTFAKKA---------------------SAFNSWFENAEEDLTDPVRCNSLEEI 2131
E L +LT +K A N + L V ++
Sbjct: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3484
Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
+ RE D +S L DF+Q+ ++ Q KS E L++ N KI
Sbjct: 3485 LSSREDKDMVQSKL-----DFSQVWYIEIQEKSHS---------RSELLQQALCN-AKIF 3529
Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT------ 2245
E E+EL E +DKL + Q + W Q++ +L ++ +
Sbjct: 3530 GEDEVELM--NWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3587
Query: 2246 ---------------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEH 2290
++ +LEA K ++++I + + D+ +E+AL L + H
Sbjct: 3588 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST------DVAKTLEQALQLARRL--H 3639
Query: 2291 ST 2292
ST
Sbjct: 3640 ST 3641
Score = 112 bits (281), Expect = 3e-24
Identities = 330/1819 (18%), Positives = 696/1819 (38%), Gaps = 265/1819 (14%)
Query: 669 LKGIKLREANQQQQFNRN-VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
LK L + +++ N V+D+ W+ E++ L ++G DL +V++ + H + +
Sbjct: 589 LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 648
Query: 728 AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
+ + I Q +K L ++Y L +++ L L
Sbjct: 649 EEFESSLKEAKISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQERHLDT---LH 702
Query: 788 QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
+E W+ EKE + + + + H L E+ E IK+V +
Sbjct: 703 NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIA 762
Query: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
++ E H A ++A + +W + Q ++++ ++F DA EA ++R
Sbjct: 763 EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 822
Query: 908 EKEPIVG---STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
+ + S D E L+++ +L Y S+I L +A++ Q
Sbjct: 823 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 882
Query: 965 DETGKEL--VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV 1021
D K + A+ DY++ E+T+ K D L N++++ WKV + VP+
Sbjct: 883 DCPLKTSIPIKAICDYRQ---IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCF 939
Query: 1022 KKLDPAQSA-SRENLLEE--QGSIALRQEQIDNQTRIT------------KEAGSVSLRM 1066
P + A N +E+ Q + L E N + + + S++
Sbjct: 940 TVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKT 999
Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKK--------FMLFREANELQQWINEKEAALTSEE 1118
E L L + + LE S + L +E N +Q+ E + EE
Sbjct: 1000 MLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREE 1059
Query: 1119 ------------------------------VGADLEQVEVLQKKFD-DFQKDLKANESRL 1147
+ LE+ ++ + F Q+ LK RL
Sbjct: 1060 QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL 1119
Query: 1148 KD----INKVAEDLESEGLMAEEVQAVQQQ---------EVYGM----MPRDETDSKTAS 1190
KD I E+ S+ + V ++ + +VY M + + +T +
Sbjct: 1120 KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 1179
Query: 1191 PWKSARLMVH-----------TVATFNSIKEL---NERWRS--------LQQLAEERSQL 1228
++A +V +A N+I+ L ++WRS L +E +
Sbjct: 1180 NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 1239
Query: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
+ E+ + +++ D +W +EK L + + + + R EG + L D
Sbjct: 1240 KAISDEMFKTYKERDLDFDWHKEKADQL-VERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1298
Query: 1289 VNSLG------ETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD- 1340
+ L ET +R IQ + PE+++ L T+LNQ L + +++K+ +
Sbjct: 1299 YHPLDDWIQQVETTQRKIQENQPENSKTL---ATQLNQQ-KMLVSEIEMKQSKMDECQKY 1354
Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELA-----KDVTGAEALLERHQEHRTEIDARAGTF 1395
+++ + +D R +V S + + + + A+ +++ + RT A
Sbjct: 1355 AEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1414
Query: 1396 QAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF----- 1450
+ +F A +K+ L++E LE+ +++ +++ ELQ +
Sbjct: 1415 TQYIKF----------AGDSLKR----LEEEEKSLEE---EKKEHVEKAKELQKWVSNIS 1457
Query: 1451 --HRDCEQA------ENWMAAREAFLNTEDKGDSLDSVEALIKKHED--FDKAINVQEEK 1500
+D E+A + +++ E E ++L +++ + KH D D+ N E++
Sbjct: 1458 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1517
Query: 1501 IAALQAFADQLIAAG------HYAKGDISSRRNEVLDRWRRLKAQ-------MIEKRSKL 1547
+ LQ + L + GD+ V +R + K + + + ++L
Sbjct: 1518 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1577
Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASD---------ESYKDPTNI---------QLSK 1589
Q E++ + S++ + D E K+ N Q K
Sbjct: 1578 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1637
Query: 1590 LLSKHQKHQAFE--AELHANADRIRGVIDMG-----NSLIERGACAGSEDAVKARLAALA 1642
L + + ++A +L+ A++ + +D E+ A + K ++ L
Sbjct: 1638 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1697
Query: 1643 DQWQFLVQKSAEKS-QKLKEANKQQNFNTGIKDFDFWLSEVEA----LLASEDYGKDLAS 1697
D W V K +E++ K K+ +Q + D + E + LL ++ G+ +
Sbjct: 1698 D-WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1756
Query: 1698 VNNLLKKHQLLEAD----ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
NL +++Q ++A IS H+ + S L + + + K+K N + K
Sbjct: 1757 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK-NMKELK 1815
Query: 1754 IKSMAA----SRRAKLNES--HRLHQFFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQN 1806
+ A ++ KL S L +F D + E W+++ + + + + G D+ G+
Sbjct: 1816 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 1875
Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSD-------------DNTIGKEEIQQRLAQF 1853
K+ K ++ +H+ ++ + +G ++ + D + E+Q++L
Sbjct: 1876 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 1935
Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQF-------VANVEEEEAWINEKMTLVASEDYGD 1905
+ ++ L G L++ ++ YQ + +A ++ EA ++ + SE
Sbjct: 1936 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL----SEPIAV 1991
Query: 1906 TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH---HEENISSKMKGLNGK 1962
+Q L++ +A + + + V + + L+ + +I + + G+
Sbjct: 1992 DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR 2051
Query: 1963 VSDLEKAAAQRKAKLDEN-SAFLQFNWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLL 2020
DL K+ +R KL + L D + W+G E+SLK + +++Q ++
Sbjct: 2052 YEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDII 2111
Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
+K + + Q ++I A+ +++ + + + MK S + ++ +
Sbjct: 2112 SKNIMLEQDIAGRQ----SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2167
Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
K+ L + +LF ++K F A ++ P + ++ L +
Sbjct: 2168 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGK-----DVTELSQYMQE 2222
Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQK 2200
S + L L ++I S + S+ LE+T NL K KE E +++
Sbjct: 2223 STSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL-----VLEKT-NNLSKKFKEMEDTIKE 2276
Query: 2201 EQRRQEENDKLRQEFAQHANAFHQWIQET--RTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
++ + F + WI+ET + ++ S E+ G LE TK+ +
Sbjct: 2277 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLEDTKKLQE 2333
Query: 2259 EIRAMRSQLKKIEDLGAAM 2277
+ +++K+ + G ++
Sbjct: 2334 KWSLKTPEIQKVNNSGISL 2352
Score = 102 bits (255), Expect = 4e-21
Identities = 450/2452 (18%), Positives = 904/2452 (36%), Gaps = 352/2452 (14%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ--IASDENYKDPTNLQGKLQKHQA 87
K L+T R Q+ F R EL W+ EK + +A D + ++ TN+ K H
Sbjct: 686 KLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEEEVAYDWSERN-TNIARKKDYHAE 743
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQ 147
E+ I + E ++ E H A TI + QW +L+
Sbjct: 744 LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ----------L 793
Query: 148 AQKLVQYLRECEDVMDWIND-KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
Q + Q+++E ++ ND KEA L + +Q+K+ +R +
Sbjct: 794 CQCVEQHIKENTAYFEFFNDAKEATDYLRNL------KDAIQRKYS---------CDRSS 838
Query: 207 EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK---LFGAAEVQRF--N 261
+++ + + +EEL++ K N + + L+ + L + ++
Sbjct: 839 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 898
Query: 262 RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL 321
R ++ TI K+ E ++A++ + E V ++C
Sbjct: 899 RQIEITI--YKDDECVLANNSHRAKWKVISP------------TGNEAMVPSVCFTVPPP 944
Query: 322 QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF-RDLTSWVTEM 380
+ A +I+ + + ++T W E H + + + R S V +
Sbjct: 945 NKEAVDLANRIEQQYQNVLTLWH-------ESHINMKSVVSWHYLINEIDRIRASNVASI 997
Query: 381 KALINADE---LASDVAGAEALLDRHQEHK----GEIDAHEDSFKSADESGQALLAAGHY 433
K ++ + L++ + E L+ QE + +I E + Q LL +
Sbjct: 998 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1057
Query: 434 ASDEVREKLTVLSEERAALLELWELRRQQYEQCM------DL-QLFYRDTEQVDNWMSKQ 486
E +SE R L L + Q DL + +R TEQ K+
Sbjct: 1058 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE---KLKK 1114
Query: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
E L +DLG + K E+F S +A + L ++QN + +T
Sbjct: 1115 ELERLKDDLG-------TITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 1166
Query: 547 RRDAL----LSRRNALHERAM---------RRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
D L L +N A+ A +AD +++ + +S V+EK
Sbjct: 1167 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1226
Query: 594 K---TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKL-IDVNHYAKD-- 647
+ DE K + + ++ + + ++ + D L + Q + + +++ +D
Sbjct: 1227 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1286
Query: 648 ------EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHL 701
+ + W + +E T+ K I+ + + + ++ + E+E
Sbjct: 1287 GIGKSLKYYRDTYHPLDDWIQQVETTQRK-IQENQPENSKTLATQLNQQKMLVSEIEMKQ 1345
Query: 702 AS-DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQE 760
+ D+ K K + L A D ++ R+ Q + A+ I ++
Sbjct: 1346 SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS----ADLIIQEFM 1401
Query: 761 ALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGV 819
L RY AL M + DSL RL++ + +E+E +KE + + K + +
Sbjct: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-----KKEHVEKAKELQKWVSNI 1456
Query: 820 QNLLKKHQALQAEIAGHEP--RIKAVTQKGNAMVEEGHFAAEDVKAKL------------ 865
LK AE AG P + K +++ + E+ A + ++ L
Sbjct: 1457 SKTLK-----DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1511
Query: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE-----KEPIVGSTDYGK 920
+EL ++ + L+ + + LQ Q D E + E KE + G D
Sbjct: 1512 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLT 1571
Query: 921 DEDSAEALLKKHEALM-----SDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLAL 975
++ L+ EA M +L Y S + L++ Q Q +A E K L
Sbjct: 1572 QTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA----EVVKNTENFL 1625
Query: 976 YDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035
+ EK +E K I LN ++ + Q K+LD + + +
Sbjct: 1626 KENGEKLSQE---DKALIEQKLNEAKIKCEQLNLKAEQS------KKELDKVVTTA---I 1673
Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
EE +A ++ +++T+I +S K E G K K ++E++ F
Sbjct: 1674 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE-------RAGTKHKQVIEQNGTHF- 1725
Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK-DINKVA 1154
Q + K A +EV +L + +V + Q++L ++K K+
Sbjct: 1726 ---------QEGDGKSAIGEEDEVNGNLLETDV-DGQVGTTQENLNQQYQKVKAQHEKII 1775
Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
++ + + Q + +++ + P ++ + ++KEL
Sbjct: 1776 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ------------------KNMKELKVH 1817
Query: 1215 WRSLQQLAEERSQLLGS-AHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQ 1272
+ + +E++ +L S E+++F D E + W+++ Q L N + D+ +
Sbjct: 1818 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1877
Query: 1273 RKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE-------------DLQEKCTELNQ 1319
++ + F D+ + + + + R++++ ++ ++Q K
Sbjct: 1878 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1937
Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVS---SDELAKDVTGAE 1375
+ SL + + L D D + D L++ + S S+ +A D +
Sbjct: 1938 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 1997
Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLL-AHGHY--ASPEIKQKLDILDQERADLEK 1432
LE + + +I ++ + ++ + LL A G A +I++ LD + DL K
Sbjct: 1998 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2057
Query: 1433 AWVQRRMMLDQCLELQLFHRD-CEQAENWMAAREAFLNTE-----DKGDSLDSVEALIKK 1486
+ +R L L L +D ++ +WM E+ L + + D + I
Sbjct: 2058 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2117
Query: 1487 HEDF---DKAINVQEEKIAALQAFADQLIAAGHYAK-GDISSRRNEVLDRWRRLKAQMIE 1542
+D +IN EK+ D A+ AK D+S+R +E + + A+M E
Sbjct: 2118 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2177
Query: 1543 KRSKLGESQTLQQFSRDVDEIEAWISEKLQ--TASDESYKDPTNIQ--LSKLLSKHQKHQ 1598
++K ++ F ++++ ++ K Q T D KD T + + + S+ +H+
Sbjct: 2178 LKTK------VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2231
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
LH+ I + V + L+ +++ + EK +
Sbjct: 2232 KHLEVLHSLLKE-----------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 2280
Query: 1659 LKEANKQQN-FNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLLKKHQLLEA 1710
+ +Q + F +K W+ E V+ +ED GK L L +K L
Sbjct: 2281 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2340
Query: 1711 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTING--------RFQKIKSMAASRR 1762
+I + L S +T+ A + VK +NG F K + + ++
Sbjct: 2341 EIQKVNNSGISL-CNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2399
Query: 1763 AKLNESHRLHQFFRDMDDEESWIKEK--KLLVGSEDYGRDLTGVQNLRK----------- 1809
+ SH + D+ + + K KL E+ + +Q + K
Sbjct: 2400 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2459
Query: 1810 -----------KHKRLEAELAAHEPAIQGVLDTGKKLSDDN--TIGKEEIQQRLAQFVEH 1856
++K EAEL + +Q + D +L ++N T +Q L +
Sbjct: 2460 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2519
Query: 1857 WKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL- 1914
W+EL QL R Q+LEES QF + + W+ EK +V+ L+ +L
Sbjct: 2520 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS---VLGPLSIDPNMLN 2576
Query: 1915 ---KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE----------NISSKMKGLNG 1961
++ + +F K + + GQ ++ + ++ K L G
Sbjct: 2577 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2636
Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
++SD Q K + + L + S K D LSS + T
Sbjct: 2637 QLSDRCDWIDQAIVKSTQYQSLL---------------RSLSDKLSDLDNKLSSSLAVST 2681
Query: 2022 KQETFDAGLQAFQQEGIANITALKDQLLAAKHV---QSKAIEARH--ASLMKRWSQLLAN 2076
+ + L+ Q+ I K Q+ A+ + S ++ + A L ++ +L +
Sbjct: 2682 HPDAMNQQLETAQKMK-QEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2740
Query: 2077 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE--NAEEDLTDPVRCNSLEEIKAL 2134
++K H + F + + F +W + E++ + P+ L+ +++L
Sbjct: 2741 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA-KLDVLESL 2799
Query: 2135 REAHDAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
+ H F +L++ + + +AE + + + + + ++ W K +KE
Sbjct: 2800 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2859
Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLD-GSCMVEESGTLESQLEA 2252
RE +L +E+ + ++ + WI + + L + C+ G E+ +
Sbjct: 2860 RENKL-------KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG--ENSIAK 2910
Query: 2253 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQ 2304
K +E+ ++ + + ++ +D + L Q+ D + +
Sbjct: 2911 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 2962
Score = 70.1 bits (170), Expect = 3e-11
Identities = 87/439 (19%), Positives = 179/439 (40%), Gaps = 52/439 (11%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIASDENY 72
+ + ++ D++ S R+ KLE++ F DA + L W+ + Q+A D+
Sbjct: 4698 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4757
Query: 73 KDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
+L + H+AF+ E+ + ++ L + +I S ++ ++ EL +W
Sbjct: 4758 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4817
Query: 132 ELLLEKMREKGIKLLQAQKLVQYLRECED-------VMDWINDKEAIVTSEE-LGQDLEH 183
E + + + + +L LR+ E+ +++W+ + E + L D +
Sbjct: 4818 ETVC------ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4871
Query: 184 VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEE-ELIKTKQDEVNAAWQRLKG 242
+ L + +EF + +N+ ++ HP+ IK + A ++ +
Sbjct: 4872 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4931
Query: 243 LALQRQGKLFGAAEVQRFNRDVDETI-SWIKEKEQLMASDD---FGRDLASVQALLRKHE 298
A Q Q +L A +++ E + +W++ E + D +++ V+AL+ +H+
Sbjct: 4932 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 4991
Query: 299 GLERDLAALE---DKV----KALCAEADRLQQSHPL--------------------SATQ 331
++ + DKV K A+ LQ P+ S TQ
Sbjct: 4992 TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQ 5051
Query: 332 IQVKREE---LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
I+ K L++ W+Q+ LA ER +LND+ L +F + + K + +
Sbjct: 5052 IETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNH 5111
Query: 389 LASDVAGAEALLDRHQEHK 407
S V +D+ Q+ K
Sbjct: 5112 KKSRVMDFFRRIDKDQDGK 5130
Score = 60.1 bits (144), Expect = 3e-08
Identities = 64/276 (23%), Positives = 114/276 (41%), Gaps = 12/276 (4%)
Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
+DL +WV EM+ ++ E SD+ E+ L+ H+ I+ E S K A S + A
Sbjct: 609 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 668
Query: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
EKL L + A LL R Q L F W++++E
Sbjct: 669 ---LKLTYAEKLHRLESQYAKLL---NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 722
Query: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
+ D + ++ H + + L +EE I ++ E A +L+ NH A + R A
Sbjct: 723 VAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 782
Query: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK-DPSN--- 606
+ ++ + + + + ++ +FF D+ E ++ +K A Y D S+
Sbjct: 783 MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL-RNLKDAIQRKYSCDRSSSIH 841
Query: 607 -LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDV 641
L+ VQ+ + EL +S I L + +I +
Sbjct: 842 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 877
Score = 57.0 bits (136), Expect = 2e-07
Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 22/279 (7%)
Query: 145 LLQAQKLVQYLRECE-------DVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTD 197
LL++ L Q L E E D+++W+++ + + E G DL VE E +
Sbjct: 588 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE---SHLENHKNV 644
Query: 198 MAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 257
A EE + + + IQ P + K + + + +L + ++ L +
Sbjct: 645 HRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTL 701
Query: 258 QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAE 317
F + W+ EKE+ + D+ ++ H L R+L E+ +K++
Sbjct: 702 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 761
Query: 318 ADR-LQQSHPLSATQIQVKREELITNWEQIRTL--AAERHARLNDSYRLQRFLADFRDLT 374
A++ L ++HP T I+ R + T W I L E+H + N +Y F D ++ T
Sbjct: 762 AEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQCVEQHIKENTAY--FEFFNDAKEAT 818
Query: 375 SWVTEMKALIN---ADELASDVAGAEALLDRHQEHKGEI 410
++ +K I + + +S + E L+ E K E+
Sbjct: 819 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 857
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 278 bits (711), Expect = 5e-74
Identities = 415/1966 (21%), Positives = 824/1966 (41%), Gaps = 178/1966 (9%)
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASET--IRTRLMELHRQ 130
+D LQ + + +AF +++A + ++T +M++ + + I+ L L +Q
Sbjct: 2790 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 2849
Query: 131 WELLLEKM--REKGIK--LLQAQKLVQYLRECEDVMDWINDKEAI-----VTSEELGQDL 181
LL++ RE+ ++ + + ++ L+E ++ + E + +E + Q L
Sbjct: 2850 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 2909
Query: 182 EHVEVLQKKFEEFQTDMAAHEERVNEVNQ----FAAKLIQEQHPEEELIKTKQDEVNAAW 237
+V QK EE + + ++ VN + Q AAK Q E +L D+VNA W
Sbjct: 2910 NMFKVFQK--EEIEP-LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL-----DDVNARW 2961
Query: 238 QRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLR 295
+ L QR +L A RF ++ +SW+ + E+L+A+ + V+A ++
Sbjct: 2962 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3021
Query: 296 KHEGLERDLAALEDKVKALCAEADRLQQS-HPLSATQIQVKREELITNWEQIRTLAAERH 354
+ + L+R L + V+ + E +++ + P +I + L + WE + A R+
Sbjct: 3022 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3081
Query: 355 ARLND-SYRLQRFLADFRDLTSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDA 412
+L S Q+F L W+T + K L+N + + + + E + +H+ + +I
Sbjct: 3082 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3141
Query: 413 HEDSFKSADESGQAL-LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-DLQ 470
H A GQ+L + + D V+ KL + E R + +Q + + +
Sbjct: 3142 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3201
Query: 471 LFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLSAQEEKITAL 526
+F D ++ NW+++ L + D S E L K+ + E L ++ AL
Sbjct: 3202 IFGEDEVELMNWLNEVHDKLSKLSVQDY--STEGLWKQQSELRVLQEDILLRKQNVDQAL 3259
Query: 527 DEFATKLIQNNHYAMEDVATRRDALLSRRNALHE------RAMRRRAQLADSFHLQQFFR 580
L Q + + + +A+ +R + + + + + QLA H
Sbjct: 3260 LNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTH--- 3316
Query: 581 DSDELKSWVNE---KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
+EL +W+++ ++ + + K Q +++ + + E N++ +D+L +
Sbjct: 3317 --EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNEVSSA 3373
Query: 638 LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN--QQQQFNRNVEDIELWLY 695
L+++ + E +M + +L+ T + ++ +A + QQF++ + W+
Sbjct: 3374 LLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT 3433
Query: 696 EVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA-GHFD 751
E E L S +D T+ Q +K +E + H+D ID + + A +
Sbjct: 3434 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHKIMTACSEEE 3491
Query: 752 AENIKKKQEALVARYEALKEPMVARKQKL--ADSLRLQQLFRDVEDEETWIREKEPIAAS 809
+++KKK + ++ Y+ + + R +L A SL + Q + E+ W+ E + I +
Sbjct: 3492 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETYEELWPWLTETQSIISQ 3550
Query: 810 TNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
+ ++ ++H+ L+ IA H+P I + + G ++E ++ K
Sbjct: 3551 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA 3610
Query: 869 NQKWEALKAKASQRRQDLEDSLQAQQYFADANEA--ESWMREKEPIVGSTDYGKDEDSAE 926
+ + +K +R L++++ F D + ES R E + + + +
Sbjct: 3611 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 3670
Query: 927 ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ----EKS 982
+ +++ + D+ + L+++ + + TD + + V D E
Sbjct: 3671 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 3730
Query: 983 PREVTMKKGDILTLLNSTNKDWWK-----VEVNDRQGFVPAAYVKKLDPA----QSASRE 1033
V ++ +L ++ K W V + D Q F+ +DP+ Q + E
Sbjct: 3731 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 3790
Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVS------LRMKQVEEL---YHSLLELGEKRK 1084
+ EE + QE++D + E + + K ++EL + SL + + R
Sbjct: 3791 TIREEIDGL---QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 3847
Query: 1085 GMLEKSCKKFMLFREANE-LQQWINEKEAALTS-EEVGADLEQVEVLQKKFDDFQKDLKA 1142
LE++ + + +++ + + W++ L S +G DLE V+ ++ F+ +
Sbjct: 3848 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 3907
Query: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
+ ++ +N AE L+ ++V +E+D HTV
Sbjct: 3908 QQIEMERLNHQAE------LLLKKVT-------------EESDK-------------HTV 3935
Query: 1203 ATFNSIKELNERWRSLQQ-LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN- 1260
+ + EL W SL++ + + +L G+ + +F DE W+ L+
Sbjct: 3936 Q--DPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 3993
Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTELNQ 1319
G D +++ KH + D+ A V ++ + LI+S E A +LQ K LNQ
Sbjct: 3994 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4053
Query: 1320 AWSSLGKRADQRKAKL-GDSHDLQRFLSDFRDLMSWINGI-RGLVSSDELAKDVTGAEAL 1377
W ++ ++ +QRK +L G + F + DL W+ R L++S L A+
Sbjct: 4054 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4113
Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQ 1436
L H E +A+ T+++ Q GQQ+LA A I Q ++ L ++ +E +
Sbjct: 4114 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4173
Query: 1437 RRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAI 1494
R+ L++ L L + FH + NW+ E LN + LD+V I +H+ F +
Sbjct: 4174 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4233
Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRN---EVLDRWRRLKAQMIEKRSKLGESQ 1551
N E+I L L K D+ +N V RW ++ +++E+ L +++
Sbjct: 4234 NSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4291
Query: 1552 T-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
+QF ++ W+ SEK + E DP I+ L++H++ Q H+
Sbjct: 4292 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ--LAQHKEFQKSLGAKHSVY 4349
Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK-QQN 1667
D G SL E+ + A + L+ L D+W + KS E+ KL+EA
Sbjct: 4350 DTTNRT---GRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4406
Query: 1668 FNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
F ++ WL VE LA + +G D+ V NL+ H+ + ++ ++ L
Sbjct: 4407 FTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4465
Query: 1726 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR--------LHQFFRD 1777
A L+ S D+S VK + ++ R++ + +++ S++ +L + R +H
Sbjct: 4466 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4525
Query: 1778 MDDEESWIKEKKLLVGSEDYGRDLTGV-QNLRKKHKRLEAELAAHEPAIQGVL-----DT 1831
+ + E ++ +L ED R L + KK + AEL VL D+
Sbjct: 4526 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 4585
Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA---ARGQRLEESLEYQQFVANVEEEE 1888
+ TI + ++ LA +H + L A A+ + LE L + Q
Sbjct: 4586 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQ--------- 4636
Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
W +T E + ++ L+ +H+ F + T + V+ V
Sbjct: 4637 -WAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 4681
Score = 265 bits (676), Expect = 5e-70
Identities = 503/2529 (19%), Positives = 1024/2529 (40%), Gaps = 298/2529 (11%)
Query: 49 FQRDAEELEKWIQEKLQIASDENYKDPTN-----LQGKLQKHQAFEAEVQANSGAIVK-L 102
FQ+ + + + W+ K + ++N P + L+ ++ H+ F + A S K +
Sbjct: 2439 FQQMSRDFQAWLDTKKE---EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2495
Query: 103 DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA-QKLVQYLRECEDV 161
E NL++ ++ +L + W+ ++++E+ KL ++ +K ++Y + E +
Sbjct: 2496 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2555
Query: 162 MDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
WI+ + + + D E K + Q +M H V +N A L+
Sbjct: 2556 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2615
Query: 222 EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE-----KEQ 276
++E++ DE + Q++ + Q K F + + ++ E K KEQ
Sbjct: 2616 DKEVVT---DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQ 2672
Query: 277 LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
L D G S L + ++ L AL+ +V A RL Q + A+ +
Sbjct: 2673 LDIHDSLGSQAYS-NKYLTMLQTQQKSLQALKHQVDL----AKRLAQDLVVEASDSKGTS 2727
Query: 337 EELITNWEQIRTLAAERHARLNDSY---------RLQ---RFLADFRDLTSWVTEMKALI 384
+ L+ Q+ T+A E H+ L+ +LQ F R++ S E +
Sbjct: 2728 DVLL----QVETIAQE-HSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDEL 2782
Query: 385 NADELASDVAGAEALLDRHQEHKG---EIDAHEDSFKSADESGQALLAAGHYASDEV--R 439
D +A AE L + + K +++A S +A+++ + +LA + D V +
Sbjct: 2783 --DSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 2840
Query: 440 EKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDTEQVDNWMSKQEAFLLNED-LGD 497
L LS++ LL+ + R +Q E + L+ FY ++ + K E ++ +G
Sbjct: 2841 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 2900
Query: 498 SLDSVEALLKKHEDFEKS----LSAQEEKITALDEFATKLIQNNHYAMEDVATRR----- 548
+++ L + F+K L +++ + L + LIQ+ A + +T+
Sbjct: 2901 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ---GLIQS---AAKSTSTQGLEHDL 2954
Query: 549 DALLSRRNALHERAMRRRAQLADSF-HLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN- 606
D + +R L+++ +R AQL ++ H +F + L SW+ + + ++ K PS
Sbjct: 2955 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ--KPPSAE 3012
Query: 607 ---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA-KDEVAARMNEVISLWKK 662
++ ++Q+ + + L +S ++ +++ G+K+ A K ++ +++ + S W+
Sbjct: 3013 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3072
Query: 663 LLEATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLAS-DDYGKDLTNVQNLQKKH 720
LL E + +L + QQF+ +E + WL +E L + + G + ++ +H
Sbjct: 3073 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3132
Query: 721 ALLEADVAAHQDRI-DGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
LE D+ H + ++I + D + ++ K + Y ++E +R +
Sbjct: 3133 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3192
Query: 780 LADSLRLQQLFRDVEDE-ETWIRE-KEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHE 837
L +L ++F + E E W+ E + ++ + + G+ + + LQ +I +
Sbjct: 3193 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3252
Query: 838 PRIKAVTQKGNAMVEEGHFAAEDV---KAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQ 893
+ G ++++ ++V + KL + +++ + ++ + LE +LQ A+
Sbjct: 3253 QNVDQALLNGLELLKQT--TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3310
Query: 894 QYFADANEAESWMR--EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
+ + E +W+ E E + T K E++++A ++ E L + + + +L E
Sbjct: 3311 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNE 3369
Query: 952 QAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVND 1011
S ++ P G E ++A + + L++ T KVE D
Sbjct: 3370 -VSSALLELVPWRAREGLEKMVA--------------EDNERYRLVSDTITQ--KVEEID 3412
Query: 1012 RQGFVPAAYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITK------------ 1057
+ + D S E L G I L Q+Q Q ++ K
Sbjct: 3413 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3472
Query: 1058 ------------------EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
E S+ ++ +V + Y ++ ++ +R LE++ F E
Sbjct: 3473 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3532
Query: 1100 A-NELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL 1157
EL W+ E ++ ++ A + E + Q++ ++ + ++ + +NK L
Sbjct: 3533 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3592
Query: 1158 ----ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNE 1213
EG +E + V +Y + D + VA +I + +
Sbjct: 3593 LELSPGEGFSIQE-KYVAADTLYSQIKED--------------VKKRAVALDEAISQSTQ 3637
Query: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
+ Q+ E +++ + + ++ KE I E N D+ +Q L
Sbjct: 3638 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK------NVSVDMEKLQPLYE 3691
Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
L G+++ + ++ I SA+ +Q+K ++ W ++ ++R+A
Sbjct: 3692 T-------LKQRGEEMIARSGGTDKDI-----SAKAVQDKLDQMVFIWENIHTLVEEREA 3739
Query: 1334 KLGDSHDL-QRFLSDFRDLMSWINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDAR 1391
KL D +L ++F D L+ I + + ++ D + + E + R EID
Sbjct: 3740 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 3799
Query: 1392 AGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
G +L+A G P +K+ +D L+ L KAW R L++ ++ +
Sbjct: 3800 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 3859
Query: 1451 HRDCEQAE-NWM-AAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508
++D QA +W+ A + G L++V+ I++ + F Q+ ++ L A
Sbjct: 3860 YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQA 3919
Query: 1509 DQLI--AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEA 1565
+ L+ K + E+ W L+ ++I ++ KL G L QF +DE+ A
Sbjct: 3920 ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 3979
Query: 1566 WIS--EKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1623
W++ E L + DP I++ KH + ++ A+ + V GN LIE
Sbjct: 3980 WLTHTEGLLSEQKPVGGDPKAIEIELA-----KHHVLQNDVLAHQSTVEAVNKAGNDLIE 4034
Query: 1624 RGACAGSEDA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSE 1681
+ AG E + ++ +L L +WQ +++K+ ++ Q+L A +Q + F+ I+D WL++
Sbjct: 4035 --SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4092
Query: 1682 VEA-LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDT-SQ 1739
E LLAS+ G + L H + A A E+ K L + ++ +
Sbjct: 4093 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4152
Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLH-QFFRDMDDEESWIK--EKKLLVGSED 1796
+ + + +++ +++ R+ KL E+ L +F + D +W+ E+ L V S
Sbjct: 4153 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4212
Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE---IQQRLAQF 1853
L V +HK E+ +H I + TG L + K++ I+ L
Sbjct: 4213 -SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISV 4269
Query: 1854 VEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQ 1911
W+++ Q RG+ L+++ + +QF + W+ E + SE + + I+
Sbjct: 4270 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4329
Query: 1912 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENIS--SKMKGLNGKVSDLEKA 1969
L +H+ F+ + G+ L +K + ++N+ + L K +
Sbjct: 4330 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4389
Query: 1970 AAQRKAKLDENSAFL-QFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTKQETF 2026
+ +R+ KL+E F QF + W+ E L D +G D+ V L+ + F
Sbjct: 4390 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAF 4448
Query: 2027 DAGLQAFQQEGIANITALKD---QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKK 2083
L + +++ ALK +L+ S ++ + L RW + A S +++ +
Sbjct: 4449 QKELG----KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4504
Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLT-DPVRCNSLEEIKALREAHDAFR 2142
L ++ R+ E+ F A W AE+ L V + + ++ L + H F
Sbjct: 4505 L---EAALRQAEE----FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4557
Query: 2143 SSLSSAQADFNQLAELDRQIKSFRVASNPYT---WFTM------EALEETWRNLQK---- 2189
L +A+ N+ + + + + T W T+ E L ++ Q+
Sbjct: 4558 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4617
Query: 2190 ----IIKERELELQKEQRRQEEN---DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEE 2242
I K+ LE + E DK ++ Q I E +T++ + M +
Sbjct: 4618 LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEE---MTRK 4674
Query: 2243 SGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVG-------- 2294
++ + KR+ + +++S + + D G A + + Y S
Sbjct: 4675 QPDVDKVTKTYKRRAADPSSLQSHIPVL-DKGRAGRKRFPASSLYPSGSQTQIETKNPRV 4733
Query: 2295 --LAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM---------------- 2336
L +W Q+ L + + L + E L+EF+
Sbjct: 4734 NLLVSKWQQVWLLALERRRKLNDALDRL-------EELREFANFDFDIWRKKYMRWMNHK 4786
Query: 2337 -------FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2389
F+ DKD+ G++ QEF + S + + E A+ D D + DG
Sbjct: 4787 KSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL-------EMSAVADIFDRDGDG 4839
Query: 2390 HVSLQEYMA 2398
++ E++A
Sbjct: 4840 YIDYYEFVA 4848
Score = 233 bits (594), Expect = 2e-60
Identities = 446/2453 (18%), Positives = 976/2453 (39%), Gaps = 266/2453 (10%)
Query: 21 QVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIAS--DENYKDPTN 77
++ ++ +L+ R+QKLE+S FQ +L++W+ EK + S DP
Sbjct: 2189 EIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2248
Query: 78 LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTRLMELHRQWELL 134
L + Q+ Q E +L G ++S E ++ +L + ++W+ L
Sbjct: 2249 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2308
Query: 135 LEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSEE-LGQDLEHVE 185
++ ++ +K Q Q L++ L + D+ + ++ A+ T + + Q LE +
Sbjct: 2309 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2368
Query: 186 VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNA---AWQRLKG 242
++++ ++ + + + +++ L++E++ + EL + + + + Q+ +
Sbjct: 2369 KMKQEIQQEKKQIKVAQALCEDLSA----LVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2424
Query: 243 LALQRQGKLFGAAEVQRFNRDVDETISWIK-EKEQLMASDDFGRDLASVQALLRKHEGLE 301
Q + + Q+ +RD +W+ +KE+ S L +++L++ H+
Sbjct: 2425 HVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2481
Query: 302 RDLAALEDKVKALCAEADRL---QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLN 358
+ L A + AE + L Q +A Q+Q+ + TNW+ ER +L
Sbjct: 2482 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT--IKTNWDTFNKQVKERENKLK 2539
Query: 359 DSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSF 417
+S + ++ L W+ + + + + D A E + + + + E+D H
Sbjct: 2540 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2599
Query: 418 KSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQ---CMD-LQLFY 473
+ + + +LL+ + V+++E +L++ ++ +Q C++ + +
Sbjct: 2600 ELLNNTANSLLSVCEIDKE-------VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 2652
Query: 474 RDTEQVDNWMSKQEAFLLNE-DLGDSLDSVEALLKKH----EDFEKSLSAQEEKITALDE 528
++ ++V +Q + D+ DSL S +A K+ + +KSL A + ++
Sbjct: 2653 KEFQEVSKESKRQLQCAKEQLDIHDSLGS-QAYSNKYLTMLQTQQKSLQALKHQVDLAKR 2711
Query: 529 FATKLI--QNNHYAMEDVATRRDALLSRRNALHERAMRR----RAQLADSFHLQQFFRDS 582
A L+ ++ DV + + + + L ++ + +L H Q R+
Sbjct: 2712 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 2771
Query: 583 DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVN 642
+ ++++ + +D LQ + + +AF +L A + D K + ++
Sbjct: 2772 FSQFAEFDDELDSMAPVG-RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATE 2830
Query: 643 HYAKDEVAARMN-EVISLW-KKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEG 699
+ D V + + E +S KLL+ + + ++ ++ ++F +++ + L + E
Sbjct: 2831 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 2890
Query: 700 HLASDD-YGKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQF--QDAGHFDAENI 755
H S G + + Q L + ++ Q + + + A + +
Sbjct: 2891 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 2950
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-VEDEETWIREKEPIAASTNR-G 813
+ + + AR++ L + + R +L ++L F+D +E +W+ + E + A+
Sbjct: 2951 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS 3010
Query: 814 KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQK 871
+ V+ +++ + LQ + + ++ + ++G + A+ VK +L L+ +
Sbjct: 3011 AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSR 3069
Query: 872 WEALKAKASQRRQDLED-SLQAQQYFADANEAESWMREKEP-IVGSTDYGKDEDSAEALL 929
WEAL KA R + LE S+ AQQ+ W+ E +V G E +
Sbjct: 3070 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3129
Query: 930 KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMK 989
+H+AL D+ + + QA S Q + K++V + D+ + E+ K
Sbjct: 3130 AQHKALEDDIINHNKHLH----QAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3185
Query: 990 KGDILTLLNST-------NKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
LL +D W EV+D+ + KL Q S E L +
Sbjct: 3186 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK--------LSKLS-VQDYSTEGLWK 3236
Query: 1038 EQGS-------IALRQEQID----NQTRITKEAGS-----VSLRMKQVEELYHSLLELGE 1081
+Q I LR++ +D N + K+ + +++ ++ Y + +L
Sbjct: 3237 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3296
Query: 1082 KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV----GADLEQVEVLQKKFDDF 1136
LE++ + +E L W+++ E L S E G + Q ++ K +
Sbjct: 3297 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK---EL 3353
Query: 1137 QKDLKANESRLKDINK--------------------VAEDLESEGLMAEEV-QAVQQQEV 1175
+K+ K N++ L +N+ VAED E L+++ + Q V++ +
Sbjct: 3354 KKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDA 3413
Query: 1176 YGMMPRD-------------ETDSKTAS--------PWKSARLMV--------------- 1199
+ + ET+ K S SA+L V
Sbjct: 3414 AILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3473
Query: 1200 -------HTVATFNSIKELNERWRSLQQL-----------AEERSQLLGSAHEVQRFHRD 1241
H + T S +E + L ++ +E QL + V +F
Sbjct: 3474 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3533
Query: 1242 ADETKEWIEEKNQALNT-DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI 1300
+E W+ E ++ + +++ Q +H +A ++ + +T +L+
Sbjct: 3534 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3593
Query: 1301 QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRD--LMSWINGI 1358
+ P +QEK + +S + + +R L ++ D D L S +
Sbjct: 3594 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 3653
Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
L ++ +V + + ++ +++ ++ +Q G++++A +I
Sbjct: 3654 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 3713
Query: 1419 KL--DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN-WMAAREAFLNTEDKGD 1475
K D LDQ + W ++++ E +L E AE W + +D D
Sbjct: 3714 KAVQDKLDQ----MVFIWENIHTLVEE-REAKLLDV-MELAEKFWCDHMSLIVTIKDTQD 3767
Query: 1476 SLDSVE------ALIKKHEDFDKAIN-----VQEEKIAALQAFADQLIAAGHYAKGDISS 1524
+ +E +++K+ ++ + I +QEE + ++ + A G K +
Sbjct: 3768 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 3827
Query: 1525 RRNEVLDRWRRLKAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS---EKLQTASDESYK 1580
+E+ W L ++ KL E+ Q Q+ + + W+ KL + S
Sbjct: 3828 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----- 3882
Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
P L + + ++ + F++E + + + L+++ + V+ L
Sbjct: 3883 -PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 3941
Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQN-FNTGIKDFDFWLSEVEALLASED-YGKDLASV 1698
L W L ++ + KL+ A F + + WL+ E LL+ + G D ++
Sbjct: 3942 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4001
Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGRFQKIKSM 1757
L KH +L+ D+ AH+ ++ +N + L+ SSA + S +++K + +N R+Q +
Sbjct: 4002 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4061
Query: 1758 AASRRAKLNESHRLHQFFR-DMDDEESWIK--EKKLLVGSEDYGRDLTGVQNLRKKHKRL 1814
R+ +L+ + R + F +++D + W+ E+ LL G T + L H +
Sbjct: 4062 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV-HMEV 4120
Query: 1815 EAELAAHEPAIQGVLDTGKK-LSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
A A E + ++ G++ L+ + I Q + E W+ ++ R +LEE
Sbjct: 4121 CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4180
Query: 1874 SLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931
+L +F ++++ W+ + + TL + L + + +H+ F + H++++
Sbjct: 4181 ALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQI 4240
Query: 1932 NDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWK 1989
++ G L + + I + + + + + + +R LD+ QF+
Sbjct: 4241 IELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEA 4300
Query: 1990 ADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT-----A 2043
+ W+ E E SL ++ + D ++T L + + F L A + + + T +
Sbjct: 4301 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA--KHSVYDTTNRTGRS 4358
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
LK++ A + ++ + L +W + S R+ KL EA + D
Sbjct: 4359 LKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL----- 4411
Query: 2104 KASAFNSWFENAEEDLTD--PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
A W E L + PV ++ + L + H AF+ L + L R+
Sbjct: 4412 --QALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4468
Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANA 2221
+ + + M+ L W + + ++ L+ R+ EE F +A
Sbjct: 4469 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEE-------FHSVVHA 4521
Query: 2222 FHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
+W+ E L + ++ L + ++ K +++ R++L K +G
Sbjct: 4522 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMG 4574
Score = 226 bits (576), Expect = 2e-58
Identities = 433/2280 (18%), Positives = 920/2280 (40%), Gaps = 246/2280 (10%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF-FQRDAEELEKWIQEKLQIASDENY- 72
+Q + + + F + R KL++S ++ E L WI + + +
Sbjct: 2513 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2572
Query: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
DP + + K ++ + E+ + G + L+ T N ++S E + L ++ +
Sbjct: 2573 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2632
Query: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND-----KEAIVTSEELGQDL---EHV 184
++ E++ K L + + Q +E ++V KE + + LG +++
Sbjct: 2633 MVTEQLHSKKFCL---ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 2689
Query: 185 EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL------IKTKQDEVNAAWQ 238
+LQ + Q + A + +V+ + A L+ E + ++T E + Q
Sbjct: 2690 TMLQTQ----QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 2745
Query: 239 RLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ------- 291
++ + KL G Q R++ + ++ MA GRD ++Q
Sbjct: 2746 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP--VGRDAETLQKQKETIK 2803
Query: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR--EELITNWEQIRTL 349
A L+K E L A D C +++ P + +KR E L ++
Sbjct: 2804 AFLKKLEAL----MASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDR 2856
Query: 350 AAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEH-- 406
A R ++ + RL+ F + ++ + + + + E + G E Q +
Sbjct: 2857 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE----HEESQGPVGMETETINQQLNMF 2912
Query: 407 ----KGEIDAHEDSFKSADESGQALLAAGHYAS---------DEVREKLTVLSEERAALL 453
K EI+ + + + GQ L+ + ++ D+V + L+++ A
Sbjct: 2913 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA--- 2969
Query: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS-LDSVEALLKKHEDF 512
+ Q E + F E + +WM E + N+ + V+A +++ +
Sbjct: 2970 ---QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL 3026
Query: 513 EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-SRRNALHERAMRRRAQLAD 571
++ L ++ + + K+ A + ++ +LL SR AL +A R QL
Sbjct: 3027 QRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3086
Query: 572 -SFHLQQFFRDSDELKSWVN--EKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
S QQF + L W+ EK + S L+ ++ +H+A E ++ + +
Sbjct: 3087 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3146
Query: 629 DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV- 687
GQ L ++ ++ + +W +E E K E QQ N +
Sbjct: 3147 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW--YIEIQE-KSHSRSELLQQALCNAKIF 3203
Query: 688 --EDIEL--WLYEVEGHLAS---DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
+++EL WL EV L+ DY + + Q + +L+ D+ + +D +
Sbjct: 3204 GEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELRVLQEDILLRKQNVDQALLN 3261
Query: 741 ARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEE- 797
+ Q G + I+ K EA+ ARY+ + + + L +L+L + +E
Sbjct: 3262 GLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3320
Query: 798 TWIR--EKEPIAASTN--RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
TW+ E E ++ T +G++ Q K+ L+ E ++ + ++ + +A++E
Sbjct: 3321 TWLDKVEVELLSYETQVLKGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLEL 3377
Query: 854 GHFAA-EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE-SWMREKEP 911
+ A E ++ + E N+++ + +Q+ ++++ ++ Q F A +AE SW+ E E
Sbjct: 3378 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3437
Query: 912 ---IVGSTDYGKDEDSAEALLKK--------HEALMSDLSAYGSSIQAL--REQAQSCRQ 958
+G +D+ SA+ ++K H+ ++ DL G I E+ QS ++
Sbjct: 3438 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3497
Query: 959 QVAPTDDETGKELVLALYDY--QEKSPREVTMKKGDILTLLNSTNKDW--------WKVE 1008
++ + VL YD Q S R + +++ L N+ W W E
Sbjct: 3498 KL---------DKVLKNYDTICQINSERYLQLERAQSLV-----NQFWETYEELWPWLTE 3543
Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITK--------EAG 1060
+PA ++ Q L E IA + ID + E
Sbjct: 3544 TQSIISQLPAPALEYETLRQQQEEHRQLREL--IAEHKPHIDKMNKTGPQLLELSPGEGF 3601
Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVG 1120
S+ + + LY + E +KR L+++ + F + ++ Q + + E +
Sbjct: 3602 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILE------SLERIV 3653
Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQ---QQEVYG 1177
L Q + + + ++ + N++ D+ K+ E+ EE+ A +++
Sbjct: 3654 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 3713
Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAE----ERSQLLGSAH 1233
+D+ D W++ +HT+ ++E + + +LAE + L+ +
Sbjct: 3714 KAVQDKLDQMVFI-WEN----IHTL-----VEEREAKLLDVMELAEKFWCDHMSLIVTIK 3763
Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
+ Q F RD ++ G D + V+ Q E ++ L ++++ +
Sbjct: 3764 DTQDFIRDLEDP----------------GIDPSVVKQQQEAAETIREEIDGLQEELDIVI 3807
Query: 1294 ETAERLIQSHPESAEDLQEKCT-ELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
LI + E + + +K ELN AW SL K R KL ++ ++ + +
Sbjct: 3808 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 3867
Query: 1352 MSWINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
W++ G L S + D+ + +E ++ ++E + + + LL
Sbjct: 3868 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 3927
Query: 1411 YASPE--IKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAF 1467
S + ++ L L LE+ + R+ L+ L L F ++ W+ E
Sbjct: 3928 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 3987
Query: 1468 LNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
L+ + G ++E + KH + + + A+ + LI + + +
Sbjct: 3988 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4047
Query: 1527 NEVLD-RWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEAWISE--------KLQTASD 1576
EVL+ RW+ + + +++ +L G + + F ++++++ W+++ K
Sbjct: 4048 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4107
Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS-EDAVK 1635
E+ K+ N+ H A A + + ++ G ++ R C S E +
Sbjct: 4108 ETAKEQLNV-----------HMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNID 4154
Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALL-ASEDYGK 1693
+ L ++W+ + K E+ KL+EA N F+ ++DF WL++ E L +
Sbjct: 4155 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSL 4214
Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQ 1752
L +V + +H++ ++++H +++ +L+ L S D +K+ ++ R++
Sbjct: 4215 ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWE 4274
Query: 1753 KIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTGVQNLRKK 1810
K+ R L+++ R QF W++E + + SE + D ++ +
Sbjct: 4275 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4334
Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ--QRLAQFVEHWKELKQLAAARG 1868
HK + L A TG+ L + ++ + ++ L++ + W + + R
Sbjct: 4335 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4394
Query: 1869 QRLEESLEYQ-QFVANVEEEEAWINEKMTLVASED--YGDTLAAIQGLLKKHEAFETDFT 1925
+LEE+L + QF ++ W+ +A + +GD + + L+ H+AF+ +
Sbjct: 4395 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELG 4453
Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ 1985
V + + ++LI+ + + +M+ L+ + + + ++ +L+ +A Q
Sbjct: 4454 KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLE--AALRQ 4511
Query: 1986 FNWKADVVES---WIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
VV + W+ E E +L+ D +++TL+ + + F L+ + E +
Sbjct: 4512 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAE-LNKA 4570
Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMK-RWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
T + D +LA H S ++++ R+ ++LA + +++L A + ++L
Sbjct: 4571 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL-- 4628
Query: 2101 FAKKASAFNSWFENAEEDLTDP---VRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
A +W + AE LTD V +EE+KAL H F ++ Q D +++ +
Sbjct: 4629 -----EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 4683
Score = 188 bits (477), Expect = 6e-47
Identities = 502/2586 (19%), Positives = 1010/2586 (39%), Gaps = 326/2586 (12%)
Query: 14 DIQERRQ---QVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEEL-EKWIQEKLQIAS 68
++ E+RQ + D + K +S + + E F + + A++L E+W +QI
Sbjct: 895 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI-- 952
Query: 69 DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
D +D L+G + + + I +++ T + S+T+ T+L
Sbjct: 953 DNRLRD---LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---- 1005
Query: 129 RQWELLLEKMREKGIKLLQAQKLV-QYLRECEDVMDWINDKEAIVTSEELG-----QDLE 182
Q ++L+ ++ K K+ + QK QY +D A+V S++ +
Sbjct: 1006 NQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQS 1065
Query: 183 HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE-LIKTKQDEVNAAWQRLK 241
+++ ++F + +T A + + +FA ++ EE+ L + K++ V A + K
Sbjct: 1066 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1125
Query: 242 GLA-LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH--- 297
++ + + K A F++ + +KEQL + L ++Q L KH
Sbjct: 1126 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEA------LQTIQLFLAKHGDK 1179
Query: 298 ------EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
LE+ + L++ L +E+ + Q S T VK EE I A
Sbjct: 1180 MTDEERNELEKQVKTLQESYNLLFSESLKQLQE---SQTSGDVKVEEKIV---------A 1227
Query: 352 ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
ER Q + + + +T+ + + + A + L ++Q + E+
Sbjct: 1228 ERQ---------QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1278
Query: 412 AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
K S QAL + ++E LS+E AL+E + + +C L L
Sbjct: 1279 ------KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKIKCEQLNL 1330
Query: 472 FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
EQ SK+E LD V K E + + Q E+ E
Sbjct: 1331 ---KAEQ-----SKKE-----------LDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1371
Query: 532 KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
+ N E T+ ++ + N H + ++ + + + ++D + V
Sbjct: 1372 DWLSNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGEEDEVNGNLLETD-VDGQVGT 1429
Query: 592 KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA 651
+ + K + + + +HQA + A QS LEK GQ L + K+++
Sbjct: 1430 TQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYL---SPEEKEKLQK 1483
Query: 652 RMNEVISLWKKLLEATELKGIKLREANQQQ--QFNRNVEDIELWLYEVEGHLASDDYGKD 709
M E+ ++ L +E K +KL + Q++ +F+ + + E WL + E L + + G D
Sbjct: 1484 NMKELKVHYETALAESEKK-MKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1542
Query: 710 -LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF---------QDAGHFDAE----NI 755
+ + K+ DV +H+ + ITI + +D G D +
Sbjct: 1543 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1602
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED---------EETWIRE-KEP 805
++K + R+ +L L D + Q + D E T + EP
Sbjct: 1603 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 1662
Query: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGHF--AAEDVK 862
IA D +Q L++ +ALQ +I+ + ++ + + +++ G A D++
Sbjct: 1663 IAV------DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 1716
Query: 863 AKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA-NEAESWMREKEPIVGSTDYGKD 921
L ++ ++E L ++R + L+ +L D +E WM E +
Sbjct: 1717 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 1776
Query: 922 EDSA-EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
+A + ++ K+ L D++ SSI A+ E+ + + TD T L + D
Sbjct: 1777 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET---TDPSTASSLQAKMKDLSA 1833
Query: 981 KSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG 1040
+ E + K + L + KVE+ + +KL + L E
Sbjct: 1834 RFS-EASHKHKETLAKMEELKT---KVELFENLS-------EKLQTFLETKTQALTE--- 1879
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE------LGEKRKGMLEKSCKKF 1094
+ + + + ++ +E+ S L K+ E+ HSLL+ L + +LEK+
Sbjct: 1880 -VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNN-- 1936
Query: 1095 MLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK------ 1148
L ++ E++ I EK+ A+TS + L+ +VL K + K+ ++
Sbjct: 1937 -LSKKFKEMEDTIKEKKEAVTSCQ--EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 1993
Query: 1149 DINKVAEDL----ESEGLMAEEVQAVQQQEVY--GMMPRDETDSKTASPWKSARLMVHTV 1202
D+ K ED E L E+Q V + ++ T +K + KS +++
Sbjct: 1994 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2053
Query: 1203 ATFNSIKEL--NERWRSLQQ---------------LAEERSQLLGSAHEVQRFHRDADET 1245
T + +E N+ S+++ L ++ ++L ++Q+ ++
Sbjct: 2054 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2113
Query: 1246 KEWIEEKNQALNTDNYGH---DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
+W+++ N+ D +V+ +++ FE +L +KV L + L++
Sbjct: 2114 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2173
Query: 1303 HPESAEDLQEK--CTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIR 1359
+P++ E + K TE++ W L + R+ KL +S ++L +F + L W+
Sbjct: 2174 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2233
Query: 1360 GLVSS-DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
+VS L+ D ++ Q E R ++ GQ +L+ P ++
Sbjct: 2234 LMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG-EDPSLR- 2291
Query: 1419 KLDILDQERADLEKAWVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK--GD 1475
I+ ++ A + + W L D+C + Q ++ + + L+ D
Sbjct: 2292 --GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2349
Query: 1476 SL------DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAA--GHYAKGDISSRRN 1527
SL D++ ++ + + I ++++I QA + L A Y K ++S +
Sbjct: 2350 SLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLE 2409
Query: 1528 EVLDRWRRLKAQ----MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
+L ++ ++ + + +S S QQ SRD +AW+ K + +++ P
Sbjct: 2410 GILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD---FQAWLDTKKE---EQNKSHPI 2463
Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA-VKARLAALA 1642
+ +L L S + H+ F L A + I G +L+ + GSE A ++ +L +
Sbjct: 2464 SAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEKAALQLQLNTIK 2521
Query: 1643 DQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
W ++ E+ KLKE+ K + ++ W+ + + L + D A N
Sbjct: 2522 TNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENS 2581
Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
+ K + L+ ++ H ++ LN+ A+SL++ D V D+ ++ + + S+
Sbjct: 2582 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2641
Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG-RDLTGVQNLRKKHKRLEAELAA 1820
+ L + + F+++ E +++L E D G Q K+ +
Sbjct: 2642 KFCLENMTQKFKEFQEVSKES----KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK 2697
Query: 1821 HEPAIQGVLDTGKKLSDDNTI------GKEEIQQRLAQFVEHWKELKQLAAARGQRLEES 1874
A++ +D K+L+ D + G ++ ++ + L Q + LE
Sbjct: 2698 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 2757
Query: 1875 LE----YQQFVANVEEEEAWINEKMTLVA-----SEDYGDTLAAIQGLLKKHEAFETDFT 1925
L+ +Q + + + A ++++ +A +E I+ LKK EA
Sbjct: 2758 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS-- 2815
Query: 1926 VHKDRVNDVCT-------NGQDLI----------KKNNHHEENISSKMKGLNGKVSDLEK 1968
D N C DL+ K+ N + ++ + + G + LE+
Sbjct: 2816 --NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE 2873
Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
+ KL E S LQ KA+ E G ++T+ + L+ + + K+E
Sbjct: 2874 FYS----KLKEFSILLQ---KAEEHEESQGPV--GMETETINQQLNMFK-VFQKEEI--E 2921
Query: 2029 GLQAFQQEGIANITALKDQLL--AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE 2086
LQ QQ+ + L L+ AAK ++ +E + RW L A R +L E
Sbjct: 2922 PLQGKQQD----VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 2977
Query: 2087 AQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP--------VRCNSLEEIKALREAH 2138
A H + +D + SW + EE + + V ++E K L+
Sbjct: 2978 ALLHCGRFQDAL-------ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLL 3030
Query: 2139 DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELEL 2198
D +S++ + + ++A ++ + L+ W L + R +L
Sbjct: 3031 DDRKSTVEVIKREGEKIATTAEPADKVKILKQ------LSLLDSRWEALLNKAETRNRQL 3084
Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
E + Q+F + ++W+ L++ + ++ LE Q+ K
Sbjct: 3085 -------EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3137
Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQW-DQLDQLGMRMQHNLEQQI 2317
+I L + +G +++ ++K S + +Q W ++ + L+Q +
Sbjct: 3138 DIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQAL 3197
Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEF--------KSCLRSLGYDLPMVEE 2369
G E L M + + DK +L+ Q++ +S LR L D+ + ++
Sbjct: 3198 CNAKIFGEDEVEL----MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3253
Query: 2370 GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAF-RALSSEGKPY 2428
+ D + +Q+ + + +R + K S ++ +AL + +
Sbjct: 3254 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3313
Query: 2429 VTKEEL 2434
T EEL
Sbjct: 3314 STHEEL 3319
Score = 167 bits (423), Expect = 1e-40
Identities = 206/996 (20%), Positives = 441/996 (44%), Gaps = 77/996 (7%)
Query: 1 MDPSGVKVLETAE----DIQERRQQVLDRYHRFKELSTLRRQKLED--SYRFQFFQRDAE 54
M+ +G ++LE + IQE+ Y + KE R L++ S QF + +
Sbjct: 3585 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3644
Query: 55 ELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD----------E 104
LE E++ E + P ++ +++K + ++ N V ++ +
Sbjct: 3645 ILESL--ERIV----ERLRQPPSISAEVEK---IKEQISENKNVSVDMEKLQPLYETLKQ 3695
Query: 105 TGNLMISEG-----HFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ------ 153
G MI+ +++ ++ +L ++ WE + + E+ KLL +L +
Sbjct: 3696 RGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 3755
Query: 154 --YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
+ +D D+I D E + G D V+ Q+ E + ++ +E ++ V
Sbjct: 3756 MSLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 3809
Query: 212 AAKLIQE-QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETIS 269
++LI P++ ++K DE+N+AW L R KL A + ++ +
Sbjct: 3810 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 3869
Query: 270 WIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLS 328
W+ +AS G DL +V+ + + + + + + +++ L +A+ L +
Sbjct: 3870 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 3929
Query: 329 ATQ--IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALIN 385
+ + +Q EL W+ + R +L + L +F +L +W+T + L++
Sbjct: 3930 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 3989
Query: 386 ADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASDEVREKL 442
+ + D E L +H + ++ AH+ + ++ +++G L+ +AG AS+ ++ KL
Sbjct: 3990 EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN-LQNKL 4048
Query: 443 TVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLL-NEDLGDSLD 500
VL++ +LE E R+QQ + + + F+ + E + W++ E LL ++ LG +
Sbjct: 4049 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4108
Query: 501 SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAME-DVATRRDALLSRRNALH 559
+ + L H + + A+EE +L + +++ + E ++ + L + ++
Sbjct: 4109 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4168
Query: 560 ERAMRRRAQLADSFHLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQG----KVQKH 614
+ R+ +L ++ +L F +S + +W+ + +T PS + ++ +H
Sbjct: 4169 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN--VASRPSLILDTVLFQIDEH 4226
Query: 615 QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISL---WKKLLEATELKG 671
+ F E+++++ +I L+K G L + K +V N +IS+ W+K+++ +G
Sbjct: 4227 KVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERG 4284
Query: 672 IKLREANQQ-QQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNLQKKHALLEADVAA 729
L +A ++ +QF+ + WL E E L S+ + D ++ +H + + A
Sbjct: 4285 RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA 4344
Query: 730 HQDRIDGITIQARQFQDAGHFDAENIKKKQ--EALVARYEALKEPMVARKQKLADSLRLQ 787
D R ++ +N+K L +++ + V R+ KL ++L
Sbjct: 4345 KHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4404
Query: 788 QLFRD-VEDEETWIREKEP-IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
F D ++ W+ EP +A D+ V NL+ H+A Q E+ ++A+ +
Sbjct: 4405 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4464
Query: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAES 904
++E + VK ++ EL+ +WE + A + ++ LE +L QA+++ + +
Sbjct: 4465 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4524
Query: 905 WMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDL 939
W+ E E + DED+ L+ +H+ M L
Sbjct: 4525 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL 4560
Score = 160 bits (405), Expect = 1e-38
Identities = 484/2522 (19%), Positives = 976/2522 (38%), Gaps = 424/2522 (16%)
Query: 9 LETAEDIQERRQQVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA 67
++ E Q + Q+ ++ K L+T L +QK+ S + Q +E +K+ ++
Sbjct: 980 IQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVS-EIEMKQSKMDECQKYAEQYSATV 1036
Query: 68 SDENYKDPTN--LQGKLQKHQAFEAEVQANSGAIV--------KLDETGNLMISEGHFAS 117
D + T + QK +Q+++ I+ + LM FA
Sbjct: 1037 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096
Query: 118 ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLV----QYLRECEDV------MDWIND 167
++++ L + + L E+ +E K + QK V + L++ E I+
Sbjct: 1097 DSLK----RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1152
Query: 168 KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE---------ERVNEVNQFAAKLIQE 218
+E E+L + L+ +++ K + TD +E E N + + K +QE
Sbjct: 1153 EEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1212
Query: 219 QHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
EE+++ +Q E Q + L Q + +L G E E +
Sbjct: 1213 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1272
Query: 273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
++E+L D G A + + L+ + L + KAL + +L ++ + Q+
Sbjct: 1273 KQEELQ-KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ--KLNEAK-IKCEQL 1328
Query: 333 QVKREELITNWEQIRTLAA-ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELAS 391
+K E+ +++ T A E ++ +L+ +L W++ N D+ S
Sbjct: 1329 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DS 1381
Query: 392 DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
+ AG + HK I+ + F+ D G++ + DEV L + ++
Sbjct: 1382 ERAGTK--------HKQVIEQNGTHFQEGD--GKSAIGE----EDEVNGNL-LETDVDGQ 1426
Query: 452 LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
+ E QQY++ Q + +S+ +A ++ + S + LL+K
Sbjct: 1427 VGTTQENLNQQYQKVK---------AQHEKIISQHQAVII------ATQSAQVLLEKQGQ 1471
Query: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
+ LS +E++ KL +N M+++ + L+ E+ M+ L +
Sbjct: 1472 Y---LSPEEKE---------KLQKN----MKELKVHYETALAES----EKKMKLTHSLQE 1511
Query: 572 SFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSN-LQGKVQKHQAFEAELSANQSRID 629
L++F D E + W+ + + + EA D N L K+++ ++F ++ +++ +
Sbjct: 1512 E--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1569
Query: 630 ALEKAGQKLIDVNHYAKD-------------EVAARMNEVISLWKKLLEATELKGIKLRE 676
+ +G ++++ EV +++ ++ L + G L++
Sbjct: 1570 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1629
Query: 677 ANQQQQFNRNVE-----DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+ Q + ++ HL S+ D N+Q ++ L+ +++ Q
Sbjct: 1630 LVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQ 1688
Query: 732 DRIDGITIQARQFQDA--GHFDAEN-IKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
++ + A DA A+N I+K + +V RYE L + + R +KL +L
Sbjct: 1689 VAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 1748
Query: 789 LFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
+D DE E+ ++E+ + ++ +Q+++ K+ L+ +IAG + I
Sbjct: 1749 SVQDGLDEMLDWMGNVESSLKEQGQVPLNST------ALQDIISKNIMLEQDIAGRQSSI 1802
Query: 841 KAVTQKGNAMVEEGH-FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA 899
A+ +K +E A ++AK+ +L+ ++ K + +E+ + F +
Sbjct: 1803 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 1862
Query: 900 NEA-ESWMREKEPIVGSTDY-GKD---------EDSAEALL-KKH----EALMSDLSAYG 943
+E ++++ K + D GKD E ++E L KKH +L+ ++S++G
Sbjct: 1863 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 1922
Query: 944 -----------------------SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
+I+ +E SC++Q+ + + LV +L + +
Sbjct: 1923 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL-----DAFQVLVKSLKSWIK 1977
Query: 981 KSPREVTMKKG-----DILTLLNSTNK--DWWKVEVNDRQ-----GFVPAAYVKKLD-PA 1027
++ ++V + + D+ L T K + W ++ + Q G + + PA
Sbjct: 1978 ETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPA 2037
Query: 1028 QSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGML 1087
++ + ++ G++ + N G S++ K + ++ H +LG K +
Sbjct: 2038 KAIAA---VKSGGAVLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI 2093
Query: 1088 EKSCKKFMLFREANE----LQQWINEKEAALTSEE---VGADLEQVEVLQKKFDDFQKDL 1140
+ K ++A E + QW+ + T + D E V+ ++ F+ +L
Sbjct: 2094 AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2153
Query: 1141 KANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
K N ++++++ +K+ E LE + D+ A WK
Sbjct: 2154 KQNVNKVQELKDKLTELLE-----------------------ENPDTPEAPRWKQM---- 2186
Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIEEKN----- 1253
+ E++ +W+ L QL +R Q L S++ + +F + K+W+ EK
Sbjct: 2187 --------LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2238
Query: 1254 --------QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPE 1305
LNT + + RK + +E+ AA ++ GE P
Sbjct: 2239 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQ-YEQLTAAGQGILSRPGED--------PS 2289
Query: 1306 SAEDLQEKCTELNQAWSSL----GKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
++E+ + Q W SL R D + S Q L D +S ++ L
Sbjct: 2290 LRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KL 2347
Query: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQL--LAHGHYASPEIKQK 1419
SS ++ LE Q+ + EI + + + L L Y E+ ++
Sbjct: 2348 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2407
Query: 1420 LDILDQERADLE-KAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK-GDSL 1477
L+ + + D+E KA + + C F + + W+ ++ N L
Sbjct: 2408 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2467
Query: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA-KGDISSRRNEVLDRWRRL 1536
D +E+LIK H+DF K + Q A + L+ + K + + N + W
Sbjct: 2468 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2527
Query: 1537 KAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS------EKLQTASDESYKDPTNIQLSK 1589
Q+ E+ +KL ES + ++ V+ + WI E+++ D + + + +L
Sbjct: 2528 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2587
Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLI--ERGACAGSEDAVKARLAALADQWQF 1647
L + +H L+ A+ + V ++ ++ E + D V +L + +
Sbjct: 2588 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 2647
Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQ 1706
+ QK E + KE+ +Q D + L S+ Y K L + K Q
Sbjct: 2648 MTQKFKEFQEVSKESKRQLQCAKEQLD-------IHDSLGSQAYSNKYLTMLQTQQKSLQ 2700
Query: 1707 LLEADISAHEDRLKDLNSQA-DSLMTSSA-FDTSQVKDKRDTINGRFQKIKSMAASRRAK 1764
L+ + + +DL +A DS TS + + T++ Q++ + K
Sbjct: 2701 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS---QQVDEKCSFLETK 2757
Query: 1765 L-------NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ----NLRKKHKR 1813
L N + F + DDE L GRD +Q ++ K+
Sbjct: 2758 LQGIGHFQNTIREMFSQFAEFDDE---------LDSMAPVGRDAETLQKQKETIKAFLKK 2808
Query: 1814 LEAELAAHEPAIQGVLDTGKKL--SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1871
LEA +A+++ A + T K + +++ + I++ L + +L A AR +++
Sbjct: 2809 LEALMASNDNANK----TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 2864
Query: 1872 EESLE-YQQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQGLLKKHEAFE-TDFTVHK 1928
E +++ ++F + ++E + + S+ G I L + F+ + +
Sbjct: 2865 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 2924
Query: 1929 DRVNDVCTNGQDLIKK--NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
+ DV GQ LI+ + + + + +N + L K AQR A+L E A L
Sbjct: 2925 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE--ALLHC 2982
Query: 1987 NWKADVVE---SWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT 2042
D +E SW+ + E + + V+ + +Q+ LQ + + +
Sbjct: 2983 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL----LQRLLDDRKSTVE 3038
Query: 2043 ALK---DQLLAAKHVQSKAIEARHASLM-KRWSQLLANSAARKKKL----LEAQSHFRKV 2094
+K +++ K + SL+ RW LL + R ++L + AQ +
Sbjct: 3039 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3098
Query: 2095 EDL--FLTFAKKA---------------------SAFNSWFENAEEDLTDPVRCNSLEEI 2131
E L +LT +K A N + L V ++
Sbjct: 3099 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3158
Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
+ RE D +S L DF+Q+ ++ Q KS E L++ N KI
Sbjct: 3159 LSSREDKDMVQSKL-----DFSQVWYIEIQEKSHS---------RSELLQQALCN-AKIF 3203
Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT------ 2245
E E+EL E +DKL + Q + W Q++ +L ++ +
Sbjct: 3204 GEDEVELM--NWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3261
Query: 2246 ---------------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEH 2290
++ +LEA K ++++I + + D+ +E+AL L + H
Sbjct: 3262 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST------DVAKTLEQALQLARRL--H 3313
Query: 2291 ST 2292
ST
Sbjct: 3314 ST 3315
Score = 112 bits (281), Expect = 3e-24
Identities = 330/1819 (18%), Positives = 696/1819 (38%), Gaps = 265/1819 (14%)
Query: 669 LKGIKLREANQQQQFNRN-VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
LK L + +++ N V+D+ W+ E++ L ++G DL +V++ + H + +
Sbjct: 263 LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 322
Query: 728 AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
+ + I Q +K L ++Y L +++ L L
Sbjct: 323 EEFESSLKEAKISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQERHLDT---LH 376
Query: 788 QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
+E W+ EKE + + + + H L E+ E IK+V +
Sbjct: 377 NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIA 436
Query: 848 NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
++ E H A ++A + +W + Q ++++ ++F DA EA ++R
Sbjct: 437 EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 496
Query: 908 EKEPIVG---STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
+ + S D E L+++ +L Y S+I L +A++ Q
Sbjct: 497 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 556
Query: 965 DETGKEL--VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV 1021
D K + A+ DY++ E+T+ K D L N++++ WKV + VP+
Sbjct: 557 DCPLKTSIPIKAICDYRQ---IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCF 613
Query: 1022 KKLDPAQSA-SRENLLEE--QGSIALRQEQIDNQTRIT------------KEAGSVSLRM 1066
P + A N +E+ Q + L E N + + + S++
Sbjct: 614 TVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKT 673
Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKK--------FMLFREANELQQWINEKEAALTSEE 1118
E L L + + LE S + L +E N +Q+ E + EE
Sbjct: 674 MLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREE 733
Query: 1119 ------------------------------VGADLEQVEVLQKKFD-DFQKDLKANESRL 1147
+ LE+ ++ + F Q+ LK RL
Sbjct: 734 QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL 793
Query: 1148 KD----INKVAEDLESEGLMAEEVQAVQQQ---------EVYGM----MPRDETDSKTAS 1190
KD I E+ S+ + V ++ + +VY M + + +T +
Sbjct: 794 KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 853
Query: 1191 PWKSARLMVH-----------TVATFNSIKEL---NERWRS--------LQQLAEERSQL 1228
++A +V +A N+I+ L ++WRS L +E +
Sbjct: 854 NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913
Query: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
+ E+ + +++ D +W +EK L + + + + R EG + L D
Sbjct: 914 KAISDEMFKTYKERDLDFDWHKEKADQL-VERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972
Query: 1289 VNSLG------ETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD- 1340
+ L ET +R IQ + PE+++ L T+LNQ L + +++K+ +
Sbjct: 973 YHPLDDWIQQVETTQRKIQENQPENSKTL---ATQLNQQ-KMLVSEIEMKQSKMDECQKY 1028
Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELA-----KDVTGAEALLERHQEHRTEIDARAGTF 1395
+++ + +D R +V S + + + + A+ +++ + RT A
Sbjct: 1029 AEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1088
Query: 1396 QAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF----- 1450
+ +F A +K+ L++E LE+ +++ +++ ELQ +
Sbjct: 1089 TQYIKF----------AGDSLKR----LEEEEKSLEE---EKKEHVEKAKELQKWVSNIS 1131
Query: 1451 --HRDCEQA------ENWMAAREAFLNTEDKGDSLDSVEALIKKHED--FDKAINVQEEK 1500
+D E+A + +++ E E ++L +++ + KH D D+ N E++
Sbjct: 1132 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1191
Query: 1501 IAALQAFADQLIAAG------HYAKGDISSRRNEVLDRWRRLKAQ-------MIEKRSKL 1547
+ LQ + L + GD+ V +R + K + + + ++L
Sbjct: 1192 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1251
Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASD---------ESYKDPTNI---------QLSK 1589
Q E++ + S++ + D E K+ N Q K
Sbjct: 1252 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1311
Query: 1590 LLSKHQKHQAFE--AELHANADRIRGVIDMG-----NSLIERGACAGSEDAVKARLAALA 1642
L + + ++A +L+ A++ + +D E+ A + K ++ L
Sbjct: 1312 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1371
Query: 1643 DQWQFLVQKSAEKS-QKLKEANKQQNFNTGIKDFDFWLSEVEA----LLASEDYGKDLAS 1697
D W V K +E++ K K+ +Q + D + E + LL ++ G+ +
Sbjct: 1372 D-WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1430
Query: 1698 VNNLLKKHQLLEAD----ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
NL +++Q ++A IS H+ + S L + + + K+K N + K
Sbjct: 1431 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK-NMKELK 1489
Query: 1754 IKSMAA----SRRAKLNES--HRLHQFFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQN 1806
+ A ++ KL S L +F D + E W+++ + + + + G D+ G+
Sbjct: 1490 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 1549
Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSD-------------DNTIGKEEIQQRLAQF 1853
K+ K ++ +H+ ++ + +G ++ + D + E+Q++L
Sbjct: 1550 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 1609
Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQF-------VANVEEEEAWINEKMTLVASEDYGD 1905
+ ++ L G L++ ++ YQ + +A ++ EA ++ + SE
Sbjct: 1610 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL----SEPIAV 1665
Query: 1906 TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH---HEENISSKMKGLNGK 1962
+Q L++ +A + + + V + + L+ + +I + + G+
Sbjct: 1666 DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR 1725
Query: 1963 VSDLEKAAAQRKAKLDEN-SAFLQFNWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLL 2020
DL K+ +R KL + L D + W+G E+SLK + +++Q ++
Sbjct: 1726 YEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDII 1785
Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
+K + + Q ++I A+ +++ + + + MK S + ++ +
Sbjct: 1786 SKNIMLEQDIAGRQ----SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 1841
Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
K+ L + +LF ++K F A ++ P + ++ L +
Sbjct: 1842 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGK-----DVTELSQYMQE 1896
Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQK 2200
S + L L ++I S + S+ LE+T NL K KE E +++
Sbjct: 1897 STSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL-----VLEKT-NNLSKKFKEMEDTIKE 1950
Query: 2201 EQRRQEENDKLRQEFAQHANAFHQWIQET--RTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
++ + F + WI+ET + ++ S E+ G LE TK+ +
Sbjct: 1951 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLEDTKKLQE 2007
Query: 2259 EIRAMRSQLKKIEDLGAAM 2277
+ +++K+ + G ++
Sbjct: 2008 KWSLKTPEIQKVNNSGISL 2026
Score = 102 bits (255), Expect = 4e-21
Identities = 450/2452 (18%), Positives = 904/2452 (36%), Gaps = 352/2452 (14%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ--IASDENYKDPTNLQGKLQKHQA 87
K L+T R Q+ F R EL W+ EK + +A D + ++ TN+ K H
Sbjct: 360 KLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEEEVAYDWSERN-TNIARKKDYHAE 417
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQ 147
E+ I + E ++ E H A TI + QW +L+
Sbjct: 418 LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ----------L 467
Query: 148 AQKLVQYLRECEDVMDWIND-KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
Q + Q+++E ++ ND KEA L + +Q+K+ +R +
Sbjct: 468 CQCVEQHIKENTAYFEFFNDAKEATDYLRNL------KDAIQRKYS---------CDRSS 512
Query: 207 EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK---LFGAAEVQRF--N 261
+++ + + +EEL++ K N + + L+ + L + ++
Sbjct: 513 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 572
Query: 262 RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL 321
R ++ TI K+ E ++A++ + E V ++C
Sbjct: 573 RQIEITI--YKDDECVLANNSHRAKWKVISP------------TGNEAMVPSVCFTVPPP 618
Query: 322 QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF-RDLTSWVTEM 380
+ A +I+ + + ++T W E H + + + R S V +
Sbjct: 619 NKEAVDLANRIEQQYQNVLTLWH-------ESHINMKSVVSWHYLINEIDRIRASNVASI 671
Query: 381 KALINADE---LASDVAGAEALLDRHQEHK----GEIDAHEDSFKSADESGQALLAAGHY 433
K ++ + L++ + E L+ QE + +I E + Q LL +
Sbjct: 672 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 731
Query: 434 ASDEVREKLTVLSEERAALLELWELRRQQYEQCM------DL-QLFYRDTEQVDNWMSKQ 486
E +SE R L L + Q DL + +R TEQ K+
Sbjct: 732 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE---KLKK 788
Query: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
E L +DLG + K E+F S +A + L ++QN + +T
Sbjct: 789 ELERLKDDLG-------TITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840
Query: 547 RRDAL----LSRRNALHERAM---------RRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
D L L +N A+ A +AD +++ + +S V+EK
Sbjct: 841 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900
Query: 594 K---TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKL-IDVNHYAKD-- 647
+ DE K + + ++ + + ++ + D L + Q + + +++ +D
Sbjct: 901 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960
Query: 648 ------EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHL 701
+ + W + +E T+ K I+ + + + ++ + E+E
Sbjct: 961 GIGKSLKYYRDTYHPLDDWIQQVETTQRK-IQENQPENSKTLATQLNQQKMLVSEIEMKQ 1019
Query: 702 AS-DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQE 760
+ D+ K K + L A D ++ R+ Q + A+ I ++
Sbjct: 1020 SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS----ADLIIQEFM 1075
Query: 761 ALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGV 819
L RY AL M + DSL RL++ + +E+E +KE + + K + +
Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-----KKEHVEKAKELQKWVSNI 1130
Query: 820 QNLLKKHQALQAEIAGHEP--RIKAVTQKGNAMVEEGHFAAEDVKAKL------------ 865
LK AE AG P + K +++ + E+ A + ++ L
Sbjct: 1131 SKTLK-----DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1185
Query: 866 HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE-----KEPIVGSTDYGK 920
+EL ++ + L+ + + LQ Q D E + E KE + G D
Sbjct: 1186 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLT 1245
Query: 921 DEDSAEALLKKHEALM-----SDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLAL 975
++ L+ EA M +L Y S + L++ Q Q +A E K L
Sbjct: 1246 QTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA----EVVKNTENFL 1299
Query: 976 YDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035
+ EK +E K I LN ++ + Q K+LD + + +
Sbjct: 1300 KENGEKLSQE---DKALIEQKLNEAKIKCEQLNLKAEQS------KKELDKVVTTA---I 1347
Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
EE +A ++ +++T+I +S K E G K K ++E++ F
Sbjct: 1348 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE-------RAGTKHKQVIEQNGTHF- 1399
Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK-DINKVA 1154
Q + K A +EV +L + +V + Q++L ++K K+
Sbjct: 1400 ---------QEGDGKSAIGEEDEVNGNLLETDV-DGQVGTTQENLNQQYQKVKAQHEKII 1449
Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
++ + + Q + +++ + P ++ + ++KEL
Sbjct: 1450 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ------------------KNMKELKVH 1491
Query: 1215 WRSLQQLAEERSQLLGS-AHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQ 1272
+ + +E++ +L S E+++F D E + W+++ Q L N + D+ +
Sbjct: 1492 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1551
Query: 1273 RKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE-------------DLQEKCTELNQ 1319
++ + F D+ + + + + R++++ ++ ++Q K
Sbjct: 1552 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1611
Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVS---SDELAKDVTGAE 1375
+ SL + + L D D + D L++ + S S+ +A D +
Sbjct: 1612 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 1671
Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLL-AHGHY--ASPEIKQKLDILDQERADLEK 1432
LE + + +I ++ + ++ + LL A G A +I++ LD + DL K
Sbjct: 1672 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 1731
Query: 1433 AWVQRRMMLDQCLELQLFHRD-CEQAENWMAAREAFLNTE-----DKGDSLDSVEALIKK 1486
+ +R L L L +D ++ +WM E+ L + + D + I
Sbjct: 1732 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 1791
Query: 1487 HEDF---DKAINVQEEKIAALQAFADQLIAAGHYAK-GDISSRRNEVLDRWRRLKAQMIE 1542
+D +IN EK+ D A+ AK D+S+R +E + + A+M E
Sbjct: 1792 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 1851
Query: 1543 KRSKLGESQTLQQFSRDVDEIEAWISEKLQ--TASDESYKDPTNIQ--LSKLLSKHQKHQ 1598
++K ++ F ++++ ++ K Q T D KD T + + + S+ +H+
Sbjct: 1852 LKTK------VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 1905
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
LH+ I + V + L+ +++ + EK +
Sbjct: 1906 KHLEVLHSLLKE-----------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 1954
Query: 1659 LKEANKQQN-FNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLLKKHQLLEA 1710
+ +Q + F +K W+ E V+ +ED GK L L +K L
Sbjct: 1955 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2014
Query: 1711 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTING--------RFQKIKSMAASRR 1762
+I + L S +T+ A + VK +NG F K + + ++
Sbjct: 2015 EIQKVNNSGISL-CNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2073
Query: 1763 AKLNESHRLHQFFRDMDDEESWIKEK--KLLVGSEDYGRDLTGVQNLRK----------- 1809
+ SH + D+ + + K KL E+ + +Q + K
Sbjct: 2074 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2133
Query: 1810 -----------KHKRLEAELAAHEPAIQGVLDTGKKLSDDN--TIGKEEIQQRLAQFVEH 1856
++K EAEL + +Q + D +L ++N T +Q L +
Sbjct: 2134 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2193
Query: 1857 WKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL- 1914
W+EL QL R Q+LEES QF + + W+ EK +V+ L+ +L
Sbjct: 2194 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS---VLGPLSIDPNMLN 2250
Query: 1915 ---KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE----------NISSKMKGLNG 1961
++ + +F K + + GQ ++ + ++ K L G
Sbjct: 2251 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2310
Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
++SD Q K + + L + S K D LSS + T
Sbjct: 2311 QLSDRCDWIDQAIVKSTQYQSLL---------------RSLSDKLSDLDNKLSSSLAVST 2355
Query: 2022 KQETFDAGLQAFQQEGIANITALKDQLLAAKHV---QSKAIEARH--ASLMKRWSQLLAN 2076
+ + L+ Q+ I K Q+ A+ + S ++ + A L ++ +L +
Sbjct: 2356 HPDAMNQQLETAQKMK-QEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2414
Query: 2077 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE--NAEEDLTDPVRCNSLEEIKAL 2134
++K H + F + + F +W + E++ + P+ L+ +++L
Sbjct: 2415 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA-KLDVLESL 2473
Query: 2135 REAHDAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
+ H F +L++ + + +AE + + + + + ++ W K +KE
Sbjct: 2474 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2533
Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLD-GSCMVEESGTLESQLEA 2252
RE +L +E+ + ++ + WI + + L + C+ G E+ +
Sbjct: 2534 RENKL-------KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG--ENSIAK 2584
Query: 2253 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQ 2304
K +E+ ++ + + ++ +D + L Q+ D + +
Sbjct: 2585 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 2636
Score = 70.1 bits (170), Expect = 3e-11
Identities = 87/439 (19%), Positives = 179/439 (40%), Gaps = 52/439 (11%)
Query: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIASDENY 72
+ + ++ D++ S R+ KLE++ F DA + L W+ + Q+A D+
Sbjct: 4372 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4431
Query: 73 KDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
+L + H+AF+ E+ + ++ L + +I S ++ ++ EL +W
Sbjct: 4432 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4491
Query: 132 ELLLEKMREKGIKLLQAQKLVQYLRECED-------VMDWINDKEAIVTSEE-LGQDLEH 183
E + + + + +L LR+ E+ +++W+ + E + L D +
Sbjct: 4492 ETVC------ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4545
Query: 184 VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEE-ELIKTKQDEVNAAWQRLKG 242
+ L + +EF + +N+ ++ HP+ IK + A ++ +
Sbjct: 4546 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4605
Query: 243 LALQRQGKLFGAAEVQRFNRDVDETI-SWIKEKEQLMASDD---FGRDLASVQALLRKHE 298
A Q Q +L A +++ E + +W++ E + D +++ V+AL+ +H+
Sbjct: 4606 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 4665
Query: 299 GLERDLAALE---DKV----KALCAEADRLQQSHPL--------------------SATQ 331
++ + DKV K A+ LQ P+ S TQ
Sbjct: 4666 TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQ 4725
Query: 332 IQVKREE---LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
I+ K L++ W+Q+ LA ER +LND+ L +F + + K + +
Sbjct: 4726 IETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNH 4785
Query: 389 LASDVAGAEALLDRHQEHK 407
S V +D+ Q+ K
Sbjct: 4786 KKSRVMDFFRRIDKDQDGK 4804
Score = 60.1 bits (144), Expect = 3e-08
Identities = 64/276 (23%), Positives = 114/276 (41%), Gaps = 12/276 (4%)
Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
+DL +WV EM+ ++ E SD+ E+ L+ H+ I+ E S K A S + A
Sbjct: 283 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 342
Query: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
EKL L + A LL R Q L F W++++E
Sbjct: 343 ---LKLTYAEKLHRLESQYAKLL---NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 396
Query: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
+ D + ++ H + + L +EE I ++ E A +L+ NH A + R A
Sbjct: 397 VAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 456
Query: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK-DPSN--- 606
+ ++ + + + + ++ +FF D+ E ++ +K A Y D S+
Sbjct: 457 MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL-RNLKDAIQRKYSCDRSSSIH 515
Query: 607 -LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDV 641
L+ VQ+ + EL +S I L + +I +
Sbjct: 516 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 551
Score = 57.0 bits (136), Expect = 2e-07
Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 22/279 (7%)
Query: 145 LLQAQKLVQYLRECE-------DVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTD 197
LL++ L Q L E E D+++W+++ + + E G DL VE E +
Sbjct: 262 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE---SHLENHKNV 318
Query: 198 MAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 257
A EE + + + IQ P + K + + + +L + ++ L +
Sbjct: 319 HRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTL 375
Query: 258 QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAE 317
F + W+ EKE+ + D+ ++ H L R+L E+ +K++
Sbjct: 376 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 435
Query: 318 ADR-LQQSHPLSATQIQVKREELITNWEQIRTL--AAERHARLNDSYRLQRFLADFRDLT 374
A++ L ++HP T I+ R + T W I L E+H + N +Y F D ++ T
Sbjct: 436 AEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQCVEQHIKENTAY--FEFFNDAKEAT 492
Query: 375 SWVTEMKALIN---ADELASDVAGAEALLDRHQEHKGEI 410
++ +K I + + +S + E L+ E K E+
Sbjct: 493 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 277 bits (708), Expect = 1e-73
Identities = 159/501 (31%), Positives = 280/501 (55%), Gaps = 26/501 (5%)
Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
+F KA + E+W KE L+ DY LS ++ LL K E F++ L A Q+ + I A
Sbjct: 398 KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRVEQIAA 456
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
+ +L + S ++ AR + +W L A + R++ L + ++ L+L +AK
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA------E 2157
+A+ FN+W E A EDL D +++EEI+ L AH+ F+++L AD +LA E
Sbjct: 517 RAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL--PDADKERLAILGIHNE 574
Query: 2158 LDRQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQE 2214
+ + ++++ V +NPYT T + + W ++++++ R+ L +E RQ+ N++LR++
Sbjct: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
Query: 2215 FAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
F AN WIQ + G +E GTLE QL ++ + I + ++ ++E
Sbjct: 635 FGAQANVIGPWIQTKMEEI--GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
Query: 2275 AAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFS 2334
++EALI DNK+T ++ + W+QL R + +E QI R+ G+++E + EF
Sbjct: 693 QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR 752
Query: 2335 MMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQ 2394
F HFD+ K+G ++ +F++CL S+GY++ + EF I+ VDPNR G V+ Q
Sbjct: 753 ASFNHFDRKKTGMMDTDDFRACLISMGYNM-------GEAEFARIMSIVDPNRLGVVTFQ 805
Query: 2395 EYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYV 2454
++ FM SRET + +++++ ++F+ L+ + K Y+T +EL + L +QA+YC++ M PY
Sbjct: 806 AFIDFM-SRETADTDTADQVMASFKILAGD-KNYITMDELRRELPPDQAEYCIARMAPYT 863
Query: 2455 DGKGRELPTAFDYVEFTRSLF 2475
+P A DY+ F+ +L+
Sbjct: 864 GPD--SVPGALDYMSFSTALY 882
Score = 83.6 bits (205), Expect = 2e-15
Identities = 83/382 (21%), Positives = 162/382 (42%), Gaps = 47/382 (12%)
Query: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFT 1925
R +RL+ E +F EAW + K ++ +DY TL+ I+ LLKKHEAFE+D
Sbjct: 388 RLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE 1979
H+DRV + Q+L + + + +++++ + + G ++ + A +R KL E
Sbjct: 446 AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505
Query: 1980 --NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
+ +L++ +A +W+ L+ + +Q L T E F A L +E
Sbjct: 506 TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565
Query: 2038 IANITALKDQLLAAKHVQSKAIEARHASLM--------------KRWSQLLANSAARKKK 2083
+A +L + SK ++ H ++ +W + R +
Sbjct: 566 LA--------ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA 617
Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDA 2140
L E + + E L F +A+ W + E+ ++ + +++ LR+
Sbjct: 618 LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ---- 673
Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL----QKIIKEREL 2196
+ S+ + + +QL + I+ + N +T +TME + W L + I E E
Sbjct: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733
Query: 2197 ELQKEQRR---QEENDKLRQEF 2215
++ + QE+ ++ R F
Sbjct: 734 QILTRDAKGISQEQMNEFRASF 755
Score = 60.1 bits (144), Expect = 3e-08
Identities = 50/250 (20%), Positives = 110/250 (44%), Gaps = 14/250 (5%)
Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
++R LD E F + E W +EA L +D + +L ++AL+KKHE F+
Sbjct: 386 IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKA------QMIEKRSKL 1547
+ ++++ + A A +L +Y +++R ++ D+W L A + +E+ KL
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
E+ Q ++++ W+ ++ D ++ T ++ L + H++ +A +
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQD-TFIVHTIEEIQGLTTAHEQFKATLPDAD 562
Query: 1606 ANADRIRGVIDMGNSLIE--RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
I G+ + + +++ AG+ + +W + Q + Q L E +
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
Query: 1664 KQQNFNTGIK 1673
+Q N ++
Sbjct: 623 ARQQHNERLR 632
Score = 58.9 bits (141), Expect = 6e-08
Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 9/137 (6%)
Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
+ ++N W L+Q L E +L H ++F + A + W + K L
Sbjct: 361 VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420
Query: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
+Y L+ ++AL +KHE FE DLAA D+V + A+ L + + + +C ++
Sbjct: 421 DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480
Query: 1319 QAWSSLGKRADQRKAKL 1335
W +LG +R+ L
Sbjct: 481 DQWDNLGALTQKRREAL 497
Score = 58.9 bits (141), Expect = 6e-08
Identities = 72/348 (20%), Positives = 142/348 (40%), Gaps = 49/348 (14%)
Query: 357 LNDSYRLQRF--LAD-FRDLTS----WVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408
LN+ RL+R LA+ FR S W +A++ D + ++ +ALL +H+ +
Sbjct: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFES 442
Query: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468
++ AH+D + Q L +Y S V + + ++ L L + RR+ E+
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
Query: 469 L-----QLFYRDTEQV---DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQ 519
L QL+ ++ +NWM L + + +++ ++ L HE F+ +L A
Sbjct: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562
Query: 520 EEK--ITALDEFATKLIQNNHYAM---------------------EDVATRRDALLSRRN 556
+E+ I + +K++Q H M + RRD L+ +
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622
Query: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
A + R R +QF ++ + W+ KM+ + + L+ ++ +
Sbjct: 623 ARQQHNERLR---------KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ 673
Query: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
+E + + +ID LE Q + + + M + W++LL
Sbjct: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721
Score = 57.4 bits (137), Expect = 2e-07
Identities = 84/389 (21%), Positives = 154/389 (39%), Gaps = 44/389 (11%)
Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
Q++E KL S L+ R + +E + E A + +D + + L K K Q
Sbjct: 274 QLMEDYEKLA-SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY---RRLHKPPKVQ 329
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657
+ +L N + ++ + + N R A SE + ++ + + W L Q + +
Sbjct: 330 E-KCQLEINFNTLQTKLRLSN----RPAFMPSEGRM---VSDINNAWGCLEQVEKGYEEW 381
Query: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLE 1709
L E + + + + F + W EA+L +DY L+ + LLKKH+ E
Sbjct: 382 LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
Query: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769
+D++AH+DR++ + + A L +D+ V + I ++ + ++ RR L +
Sbjct: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
Query: 1770 RLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821
+L + + E +W++ + + +Q L H++ +A L
Sbjct: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
Query: 1822 EP---AIQGVLDTGKKLSDD---NTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEES 1874
+ AI G+ + K+ N G Q + W ++QL R Q L E
Sbjct: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
Query: 1875 LEYQ--------QFVANVEEEEAWINEKM 1895
Q QF A WI KM
Sbjct: 622 HARQQHNERLRKQFGAQANVIGPWIQTKM 650
Score = 57.0 bits (136), Expect = 2e-07
Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 25/235 (10%)
Query: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE 207
Q + Y + D+++WI + + ++ H +Q+K E+F+ H+ +V E
Sbjct: 274 QLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHA--MQQKLEDFRDYRRLHKPPKVQE 330
Query: 208 -------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRLKGLA----------LQRQG 249
N KL P + + ++N AW L+ + ++R
Sbjct: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALE 308
+L AE R + E +W KE ++ D+ L+ ++ALL+KHE E DLAA +
Sbjct: 391 RLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448
Query: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
D+V+ + A A L + + + + +++ W+ + L +R L + +L
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Score = 57.0 bits (136), Expect = 2e-07
Identities = 68/347 (19%), Positives = 143/347 (41%), Gaps = 31/347 (8%)
Query: 32 LSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPT--NLQGKLQKHQAFE 89
L+ +RR + D +F Q+ A E W K + ++Y+ T ++ L+KH+AFE
Sbjct: 383 LNEIRRLERLDHLAEKFRQK-ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441
Query: 90 AEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE---LLLEKMR---EKGI 143
+++ A+ + ++ + ++ S ++ R ++ QW+ L +K R E+
Sbjct: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501
Query: 144 KLLQA--QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMA-A 200
KLL+ Q ++Y + +W+ + + +E ++ L E+F+ + A
Sbjct: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561
Query: 201 HEER--VNEVNQFAAKLIQEQHPE----EELIKTKQDEVNAAWQRLKGLALQRQGKLFGA 254
+ER + ++ +K++Q H E+N W ++ L +R L
Sbjct: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621
Query: 255 AEVQRFNRDVDETIS--------WIKEKEQLMA--SDDFGRDLASVQALLRKHEGLERDL 304
Q+ N + + WI+ K + + S + L + LR++ E+ +
Sbjct: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQY---EKSI 678
Query: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
+ K+ L + +Q++ E + WEQ+ T A
Sbjct: 679 VNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725
Score = 57.0 bits (136), Expect = 2e-07
Identities = 57/286 (19%), Positives = 118/286 (41%), Gaps = 31/286 (10%)
Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
++F + E W E L DY L+ ++ L KKH E+D+AAHQDR++ I
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQLFRDV 793
A++ + ++D+ ++ + + + +++ L + + R +KL ++ + QL+ +
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET--IDQLYLEY 514
Query: 794 EDE----ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR---IKAVTQK 846
W+ T + +Q L H+ +A + + I + +
Sbjct: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE 574
Query: 847 GNAMVEEGHFAAEDVKAKL----HELNQKWEALKAKASQRRQDLEDSLQAQ--------Q 894
+ +V+ H E+N KW+ ++ +R Q L + Q Q
Sbjct: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634
Query: 895 YFADANEAESWMREKEPIVGSTD---YGKDEDSAEALLKKHEALMS 937
+ A AN W++ K +G +G ED L + +++++
Sbjct: 635 FGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVN 680
Score = 54.3 bits (129), Expect = 1e-06
Identities = 65/317 (20%), Positives = 127/317 (40%), Gaps = 34/317 (10%)
Query: 482 WMSKQEAFLLNEDLGDS-LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
W +EA L +D + L ++ALLKKHE FE L+A ++++ + A +L + ++Y
Sbjct: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWVNE 591
V R + + + L +RR L D +L ++ + + +W+
Sbjct: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYL-EYAKRAAPFNNWMEG 527
Query: 592 KMKTATDE-AYKDPSNLQGKVQKHQAFEAEL-SANQSRIDAL--EKAGQKLIDVNHY--- 644
M+ D +QG H+ F+A L A++ R+ L K++ H
Sbjct: 528 AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA 587
Query: 645 -AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVED--------IELWL- 694
E+ W + + + L E + +QQ N + I W+
Sbjct: 588 GTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQ 647
Query: 695 --YEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDA 752
E G ++ + +G + +L++ E + ++ +ID + + Q+A FD
Sbjct: 648 TKMEEIGRISIEMHGTLEDQLSHLRQ----YEKSIVNYKPKIDQLEGDHQLIQEALIFDN 703
Query: 753 ENIKKKQEALVARYEAL 769
++ E + +E L
Sbjct: 704 KHTNYTMEHIRVGWEQL 720
Score = 51.6 bits (122), Expect = 9e-06
Identities = 65/326 (19%), Positives = 136/326 (41%), Gaps = 54/326 (16%)
Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093
N L+ + ++ R + ++ R+ + + ++QVE+ Y L +R L+ +K
Sbjct: 339 NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
Query: 1094 FMLFREANELQQWINEKEAALTSEEVG-ADLEQVEVLQKKFDDFQKDLKANESRLKDINK 1152
F ++A+ + W + KEA L ++ A L +++ L KK + F+ DL A++ R++ I
Sbjct: 399 FR--QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 1153 VAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELN 1212
+A++L + + Y SP +AR +++
Sbjct: 457 IAQELN-------------ELDYYD------------SPSVNARC-----------QKIC 480
Query: 1213 ERWRSLQQLAEERSQLLGSAHEVQR--------FHRDADETKEWIEEKNQALNTDNYGHD 1264
++W +L L ++R + L ++ + + A W+E + L H
Sbjct: 481 DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540
Query: 1265 LASVQALQRKHEGFERDLA-ALGDKVNSLG--ETAERLIQSHPESAEDLQEKCT----EL 1317
+ +Q L HE F+ L A +++ LG +++Q++ + T E+
Sbjct: 541 IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600
Query: 1318 NQAWSSLGKRADQRKAKLGDSHDLQR 1343
N W + + +R L + H Q+
Sbjct: 601 NGKWDHVRQLVPRRDQALTEEHARQQ 626
Score = 51.6 bits (122), Expect = 9e-06
Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 9/121 (7%)
Query: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621
RR + D HL + FR + ++W + K + Y+ S ++ ++KH+AFE++L
Sbjct: 387 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444
Query: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
+A+Q R++ + Q+L ++++Y V AR ++ W L T+ K REA ++
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ----KRREALERT 500
Query: 682 Q 682
+
Sbjct: 501 E 501
Score = 48.5 bits (114), Expect = 8e-05
Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 8/114 (7%)
Query: 776 RKQKLADSLRLQQLFRDV--EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEI 833
R LA+ R + + + +E +R+K+ A+ + ++ LLKKH+A ++++
Sbjct: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE------IKALLKKHEAFESDL 444
Query: 834 AGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
A H+ R++ + + E ++ + V A+ ++ +W+ L A +RR+ LE
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498
Score = 40.4 bits (93), Expect = 0.022
Identities = 55/290 (18%), Positives = 115/290 (39%), Gaps = 32/290 (11%)
Query: 1315 TELNQAWSSLGK-RADQRKAKLGDSHDLQRF---LSDFRDLMS----WINGIRGLV-SSD 1365
+++N AW L + + L + L+R FR S W +G ++ D
Sbjct: 362 SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKD 421
Query: 1366 ELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQ 1425
++ +ALL++H+ +++ A + Q+L +Y SP + + +
Sbjct: 422 YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481
Query: 1426 ERADLEKAWVQRRMMLDQCLEL-----QLFHRDCEQA---ENWMAAREAFLNTEDKGDSL 1477
+ +L +RR L++ +L QL+ ++A NWM L ++
Sbjct: 482 QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541
Query: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAAL----------QAFADQLIAAGHY---AKGDIS 1523
+ ++ L HE F + + +E++A L Q + + Y +I+
Sbjct: 542 EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601
Query: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQ 1572
+ + V R + E+ ++ ++ L +QF + I WI K++
Sbjct: 602 GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKME 651
Score = 38.5 bits (88), Expect = 0.083
Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA-EALLKKHEALMSDLS 940
RR + D L A+++ A+ E+W KE ++ DY S +ALLKKHEA SDL+
Sbjct: 387 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445
Query: 941 AYGSSIQALREQAQSCRQ 958
A+ ++ + AQ +
Sbjct: 446 AHQDRVEQIAAIAQELNE 463
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 260 bits (665), Expect = 1e-68
Identities = 156/500 (31%), Positives = 271/500 (54%), Gaps = 24/500 (4%)
Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGRDL-SSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
+F KA + E+W KE L DY L V+ LL + E F++ L A Q+ + +I A
Sbjct: 412 KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAA-HQDRVEHIAA 470
Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
L +L + ++ ++ +R ++ +W L + R+ L + ++ L L FA+
Sbjct: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530
Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIK 2163
+A+ FN+W + A EDL D +S+EE ++L AHD F+++L A + + + +I+
Sbjct: 531 RAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQ 590
Query: 2164 SF-------RVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2216
++NPY + + + W ++K++ R+ LQ+E RQ+ N++LR++FA
Sbjct: 591 KICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFA 650
Query: 2217 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2276
ANA WIQ + G +G+LE Q+ +++ Q I ++ + ++E
Sbjct: 651 AQANAIGPWIQAKVEEV--GRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQL 708
Query: 2277 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2336
++E+L+ DNK+T +S + W+QL R + +E Q+ R+ G+++E L EF
Sbjct: 709 LQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRAS 768
Query: 2337 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2396
F HFD+ ++G + +F++CL S+GYDL V EF I+ VDPN G V+ Q +
Sbjct: 769 FNHFDRKRNGMMEPDDFRACLISMGYDLGEV-------EFARIMTMVDPNAAGVVTFQAF 821
Query: 2397 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2456
+ FM +RET ++E++ ++F+ L+ + K Y+T EEL + L +QA+YC+ M PY
Sbjct: 822 IDFM-TRETAETDTTEQVVASFKILAGD-KNYITPEELRRELPAKQAEYCIRRMVPY--- 876
Query: 2457 KGRELPT-AFDYVEFTRSLF 2475
KG P A DYV F+ +L+
Sbjct: 877 KGSGAPAGALDYVAFSSALY 896
Score = 77.0 bits (188), Expect = 2e-13
Identities = 90/428 (21%), Positives = 181/428 (42%), Gaps = 39/428 (9%)
Query: 1820 AHEPAIQGVLDTGKKLSDDNTI--GKEEIQQRLAQFVEHW--KELKQLAAARGQRLEESL 1875
+H PA GK +SD G E++++ E W E+++L QRL+
Sbjct: 362 SHRPAFMP--SEGKLVSDIANAWRGLEQVEKGY----EDWLLSEIRRL-----QRLQHLA 410
Query: 1876 EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAA-IQGLLKKHEAFETDFTVHKDRVNDV 1934
E +F EAW K +++ DY L ++ LL++HEAFE+D H+DRV +
Sbjct: 411 E--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHI 468
Query: 1935 CTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE--NSAFLQF 1986
Q+L + + H +++S+ + + G ++ + A +R KL E + L+F
Sbjct: 469 AALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEF 528
Query: 1987 NWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQE--GIANITAL 2044
+A +W+ L+ + Q+LLT + F A L +E I I
Sbjct: 529 ARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGE 588
Query: 2045 KDQLLAAKHVQ----SKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
++ ++ + I + +W + +R + L E + + E L
Sbjct: 589 IQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQ 648
Query: 2101 FAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
FA +A+A W + E+ L + + E++ LR+ ++ + + + ++L
Sbjct: 649 FAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQ----EQNIINYKTNIDRLEG 704
Query: 2158 LDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQ 2217
+ ++ V N +T ++ME + W L I E++ + ++ +++ +
Sbjct: 705 DHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNE 764
Query: 2218 HANAFHQW 2225
+F+ +
Sbjct: 765 FRASFNHF 772
Score = 64.7 bits (156), Expect = 1e-09
Identities = 56/212 (26%), Positives = 90/212 (42%), Gaps = 20/212 (9%)
Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
+ ++ WR L+Q L E +L H ++F + A + W K + L+
Sbjct: 375 VSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQR 434
Query: 1260 NYGHDLAS-VQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
+Y L V+AL R+HE FE DLAA D+V + A+ L + A + +C +
Sbjct: 435 DYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAIC 494
Query: 1319 QAWSSLG----KRAD--QRKAKLGDSHD-LQ-RFLSDFRDLMSWINGIRGLVSSDELAKD 1370
W +LG KR D +R KL ++ D LQ F +W++G + L
Sbjct: 495 DQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHS 554
Query: 1371 VTGAEALLERHQEHRT---EIDARAGTFQAFE 1399
V ++LL H + + E D G +
Sbjct: 555 VEETQSLLTAHDQFKATLPEADRERGAIMGIQ 586
Score = 58.9 bits (141), Expect = 6e-08
Identities = 70/310 (22%), Positives = 132/310 (42%), Gaps = 59/310 (19%)
Query: 136 EKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQ 195
EK+ E+ KL A +L++++R + W+ ++ +G+ + +Q+K E+F+
Sbjct: 287 EKLMEEYEKL--ASELLEWIRR---TVPWLENR--------VGEP--SMSAMQRKLEDFR 331
Query: 196 TDMAAHEE-RVNE-------VNQFAAKLIQEQHP-----EEELIKTKQDEVNAAWQRLKG 242
H+ R+ E N KL P E +L+ ++ AW+ L+
Sbjct: 332 DYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVS----DIANAWRGLEQ 387
Query: 243 LA----------LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLAS-VQ 291
+ ++R +L AE R + E +W + KE++++ D+ L V+
Sbjct: 388 VEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHE--AWTRGKEEMLSQRDYDSALLQEVR 445
Query: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
ALLR+HE E DLAA +D+V+ + A A L + A + + + + W+ + TL
Sbjct: 446 ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQ 505
Query: 352 ERHARLNDSYRLQRFLADFRDL-----------TSWVTEMKALINADELASDVAGAEALL 400
+R L R+++ L L +W+ + L V ++LL
Sbjct: 506 KRRDALE---RMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLL 562
Query: 401 DRHQEHKGEI 410
H + K +
Sbjct: 563 TAHDQFKATL 572
Score = 57.0 bits (136), Expect = 2e-07
Identities = 56/264 (21%), Positives = 106/264 (40%), Gaps = 36/264 (13%)
Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGKDLTN-VQNLQKKHALLEADVAAHQDRIDGITI 739
++F + E W E L+ DY L V+ L ++H E+D+AAHQDR++ I
Sbjct: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470
Query: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQL--FR 791
A++ + + +A ++ + +A+ +++ L + + R +KL +++ QL R
Sbjct: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530
Query: 792 DVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMV 851
W+ + Q+LL H +A + +A ++G M
Sbjct: 531 RAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP------EADRERGAIMG 584
Query: 852 EEGHF-------------AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQ----- 893
+G + ++N KW+ ++ R Q L++ L Q
Sbjct: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNER 644
Query: 894 ---QYFADANEAESWMREKEPIVG 914
Q+ A AN W++ K VG
Sbjct: 645 LRRQFAAQANAIGPWIQAKVEEVG 668
Score = 55.5 bits (132), Expect = 7e-07
Identities = 85/420 (20%), Positives = 160/420 (38%), Gaps = 63/420 (15%)
Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
+++E+ KL S+ L+ R V +E + E +A +D + + + Q+
Sbjct: 288 KLMEEYEKLA-SELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKC 346
Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657
E + ++R L R A SE + ++ +A+ W+ L Q + +
Sbjct: 347 QLEINFNTLQTKLR--------LSHRPAFMPSEGKL---VSDIANAWRGLEQVEKGYEDW 395
Query: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGKDLAS-VNNLLKKHQLLE 1709
L E + Q + F + W E +L+ DY L V LL++H+ E
Sbjct: 396 LLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFE 455
Query: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769
+D++AH+DR++ + + A L + + V + I ++ + ++ RR L
Sbjct: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERME 515
Query: 1770 RL--------HQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEA---EL 1818
+L +F R +W+ + + Q+L H + +A E
Sbjct: 516 KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEA 575
Query: 1819 AAHEPAIQGVLDTGKKLSDDN-----------TIGKEEIQQRLAQFVEHWKELKQLAAAR 1867
AI G+ +K+ T+ ++I + W +++L +R
Sbjct: 576 DRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTK-------WDMVRKLVPSR 628
Query: 1868 GQRLEESLEYQ--------QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEA 1919
Q L+E L Q QF A WI K+ E+ G A + G L++ A
Sbjct: 629 DQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKV-----EEVGRLAAGLAGSLEEQMA 683
Score = 54.3 bits (129), Expect = 1e-06
Identities = 87/419 (20%), Positives = 165/419 (39%), Gaps = 52/419 (12%)
Query: 751 DAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED-EETWIREKEPIAAS 809
D N + E + YE + R Q+L L + FR E W R KE + +
Sbjct: 377 DIANAWRGLEQVEKGYEDWLLSEIRRLQRLQ---HLAEKFRQKASLHEAWTRGKEEMLSQ 433
Query: 810 TNRGKDLIG-VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
+ L+ V+ LL++H+A ++++A H+ R++ + + E + A V ++ +
Sbjct: 434 RDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI 493
Query: 869 NQKWEALKAKASQRRQDLE---------DSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
+W+ L +RR LE D LQ ++ A +W+ +
Sbjct: 494 CDQWDNLGTLTQKRRDALERMEKLLETIDQLQL-EFARRAAPFNNWLDGAVEDLQDVWLV 552
Query: 920 KDEDSAEALLKKHE---ALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976
+ ++LL H+ A + + +I ++ + Q Q T + L
Sbjct: 553 HSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITL--- 609
Query: 977 DYQEKSPREVTMKKGDILTLLNSTN----KDWWKVEVNDRQGFVPAAYVKKLDPAQSASR 1032
SP+++ K + L+ S + ++ + +VN+R AA + P A
Sbjct: 610 -----SPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKV 664
Query: 1033 ENL----------LEEQGSIALRQEQ--IDNQTRITKEAGSVSLRMKQ-VEELYHSLLEL 1079
E + LEEQ + +QEQ I+ +T I + G L + V + H++ +
Sbjct: 665 EEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSM 724
Query: 1080 GEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK 1138
R G + + R NE++ + LT + G EQ+ + F+ F +
Sbjct: 725 EHIRVGWEQLLTS---IARTINEVENQV------LTRDAKGLSQEQLNEFRASFNHFDR 774
Score = 48.5 bits (114), Expect = 8e-05
Identities = 70/338 (20%), Positives = 132/338 (39%), Gaps = 42/338 (12%)
Query: 362 RLQRFLADFRDLTS----WVTEMKALINADELASDVAG-AEALLDRHQEHKGEIDAHEDS 416
RLQ FR S W + +++ + S + ALL RH+ + ++ AH+D
Sbjct: 405 RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
Query: 417 FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-------DL 469
+ Q L ++ + V + + ++ L L + RR E+ L
Sbjct: 465 VEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQL 524
Query: 470 QL-FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL-- 526
QL F R +NW+ L + L S++ ++LL H+ F+ +L + + A+
Sbjct: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
Query: 527 ---------DEFATKLIQNNHY---AMEDVATR----RDALLSRRNALHERAMRRRAQLA 570
+ + N Y + +D+ T+ R + SR L E R Q
Sbjct: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELAR---QQV 641
Query: 571 DSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSAN----QS 626
+ +QF ++ + W+ K+ +E + + L G +++ A + N ++
Sbjct: 642 NERLRRQFAAQANAIGPWIQAKV----EEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKT 697
Query: 627 RIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
ID LE Q L + + M + W++LL
Sbjct: 698 NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
Score = 48.5 bits (114), Expect = 8e-05
Identities = 79/386 (20%), Positives = 145/386 (37%), Gaps = 43/386 (11%)
Query: 1769 HRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTG-VQNLRKKHKRLEAELAAHEPAIQG 1827
H +F + E+W + K+ ++ DY L V+ L ++H+ E++LAAH+ ++
Sbjct: 408 HLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEH 467
Query: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
+ ++L++ + + R + W L L R LE + + + ++ E
Sbjct: 468 IAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE 527
Query: 1888 EA--------WINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQ 1939
A W++ + + ++ Q LL H+ F+ DR Q
Sbjct: 528 FARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP-EADRERGAIMGIQ 586
Query: 1940 DLIKK--------NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWK-- 1989
I+K I+ + +N K + K R L E A Q N +
Sbjct: 587 GEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLR 646
Query: 1990 ------ADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
A+ + WI K ++ GR + + L +Q AGL+ Q++ I N
Sbjct: 647 RQFAAQANAIGPWI-----QAKVEEVGRLAAGLAGSLEEQM---AGLRQ-QEQNIINYKT 697
Query: 2044 LKDQLLAAKHV--QSKAIEARHA-----SLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2096
D+L + +S + +H + W QLL S AR +E Q R +
Sbjct: 698 NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL-TSIARTINEVENQVLTRDAKG 756
Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDP 2122
L + A + F+ + +P
Sbjct: 757 LSQEQLNEFRASFNHFDRKRNGMMEP 782
Score = 45.4 bits (106), Expect = 7e-04
Identities = 71/378 (18%), Positives = 144/378 (38%), Gaps = 36/378 (9%)
Query: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
PS K++ + +QV Y + R Q+L+ + + F++ A E W +
Sbjct: 369 PSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQ--HLAEKFRQKASLHEAWTRG 426
Query: 63 KLQIASDENYKDPT--NLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
K ++ S +Y ++ L++H+AFE+++ A+ + + + + + ++
Sbjct: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
Query: 121 RTRLMELHRQWE---LLLEKMR---EKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172
+R + QW+ L +K R E+ KLL+ Q +++ R +W++ +
Sbjct: 487 NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDL 546
Query: 173 TSEELGQDLEHVEVLQKKFEEFQTDM-AAHEER------VNEVNQFAAKLIQEQHPEEEL 225
L +E + L ++F+ + A ER E+ +
Sbjct: 547 QDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPY 606
Query: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277
I ++N W ++ L R L Q+ N + + WI+ K
Sbjct: 607 ITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK--- 663
Query: 278 MASDDFGRDLASVQALLRKH-EGL---ERDLAALEDKVKALCAEADRLQQSHPLSATQIQ 333
++ GR A + L + GL E+++ + + L + LQ+S
Sbjct: 664 --VEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTV 721
Query: 334 VKREELITNWEQIRTLAA 351
E + WEQ+ T A
Sbjct: 722 YSMEHIRVGWEQLLTSIA 739
Score = 45.1 bits (105), Expect = 9e-04
Identities = 37/163 (22%), Positives = 76/163 (46%), Gaps = 17/163 (10%)
Query: 574 HLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAELSANQSRIDA 630
HL + FR L ++W K + + Y ++ +++H+AFE++L+A+Q R++
Sbjct: 408 HLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEH 467
Query: 631 LEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQ--------QQQ 682
+ Q+L +++++ V +R + W L T+ + L + Q +
Sbjct: 468 IAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE 527
Query: 683 FNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEA 725
F R WL +G A +D +D+ V ++++ +LL A
Sbjct: 528 FARRAAPFNNWL---DG--AVEDL-QDVWLVHSVEETQSLLTA 564
Score = 43.5 bits (101), Expect = 0.003
Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 17/180 (9%)
Query: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSL-DSVEALLKKHEDFE 513
L E+RR Q Q + + F + + W +E L D +L V ALL++HE FE
Sbjct: 397 LSEIRRLQRLQHL-AEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFE 455
Query: 514 KSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-----------SRRNALHERA 562
L+A ++++ + A +L + +++ V +R A+ RR+AL
Sbjct: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALER-- 513
Query: 563 MRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDE-AYKDPSNLQGKVQKHQAFEAEL 621
M + + D L +F R + +W++ ++ D Q + H F+A L
Sbjct: 514 MEKLLETIDQLQL-EFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATL 572
Score = 33.1 bits (74), Expect = 3.5
Identities = 64/309 (20%), Positives = 117/309 (37%), Gaps = 41/309 (13%)
Query: 1235 VQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFE-----------RDLA 1283
++ + + A E EWI L + G S+ A+QRK E F ++
Sbjct: 290 MEEYEKLASELLEWIRRTVPWLE-NRVGEP--SMSAMQRKLEDFRDYRRLHKPPRIQEKC 346
Query: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKC-TELNQAWSSLGK----RADQRKAKLGDS 1338
L N+L +T RL SH + + K +++ AW L + D +++
Sbjct: 347 QLEINFNTL-QTKLRL--SHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRL 403
Query: 1339 HDLQRFLSDFRDLMS----WINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDARAG 1393
LQ FR S W G ++S D + + ALL RH+ +++ A
Sbjct: 404 QRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQD 463
Query: 1394 TFQAFEQFGQQLLAHGHYASPEIKQK----------LDILDQERADLEKAWVQRRMMLDQ 1443
+ Q+L ++ + + + L L Q+R D A + +L+
Sbjct: 464 RVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRD---ALERMEKLLET 520
Query: 1444 CLELQL-FHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIA 1502
+LQL F R NW+ L S++ ++L+ H+ F + + +
Sbjct: 521 IDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERG 580
Query: 1503 ALQAFADQL 1511
A+ ++
Sbjct: 581 AIMGIQGEI 589
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 258 bits (658), Expect = 7e-68
Identities = 473/2464 (19%), Positives = 982/2464 (39%), Gaps = 250/2464 (10%)
Query: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY-RFQFFQRDAEELEKWIQEK--LQI 66
+ AE+ ++ ++++ R+ R E++ R+++LE+S FQ +L W+ EK +
Sbjct: 2977 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 3036
Query: 67 ASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTR 123
DP L + Q+ Q E +A +L+E +++ + ++ ++
Sbjct: 3037 VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKE 3096
Query: 124 LMELHRQWELLLEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSE 175
L ++++W L +K+ + +K Q Q+L+Q L E V ++ + AI T
Sbjct: 3097 LQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQP 3156
Query: 176 E-LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234
E + Q LE ++ E+ ++ + +E++ LI EQ+ ++EL K + + V
Sbjct: 3157 EAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV----LIGEQYLKDEL-KKRLETVA 3211
Query: 235 AAWQRLKGLALQRQGKLFGA-AEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQA 292
Q L+ LA R +L A A Q+F + DE +W+ +K+ A + L +Q+
Sbjct: 3212 LPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQS 3271
Query: 293 LLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ--IQVKREELITNWEQIRTLA 350
L+++E ++ L + + AE + L S P + +Q + EL +WE++
Sbjct: 3272 QLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 3331
Query: 351 AERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGE 409
A+R +RL D + Q++ DL W+ + KA ++ + D E+ L R + E
Sbjct: 3332 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE 3391
Query: 410 IDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDL 469
++ + + + L+ + D +R++ +++ A+ E + + E+
Sbjct: 3392 VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMT-- 3449
Query: 470 QLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEF 529
Q E N K E ++ D+L S K E L AQ+E + AL+
Sbjct: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE----KLRAQQEVLQALEPQ 3505
Query: 530 ATKLIQNNHYAMEDVATRRDA--LLSRRNALHERAMRRRAQL-ADSFHLQQFFRDSDELK 586
L +ED DA LL + + + + ++ + ++ +
Sbjct: 3506 VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFH 3565
Query: 587 SWVNEKMKTATD---------EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
V E D +D +LQ +++ + F ++ + I+A E
Sbjct: 3566 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA---- 3621
Query: 638 LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEV 697
+ H ++E +++ L K+ LEA + KL E + +Q E +EL L V
Sbjct: 3622 --ECRHMLEEEGTL---DLLGL-KRELEALNKQCGKLTERGKARQ-----EQLELTLGRV 3670
Query: 698 EGHLASDDYGKDLTNVQNLQKKHAL-----LEADVAAHQ---------DRIDGITIQARQ 743
E D T ++ AL E ++ Q +++D + ++ +Q
Sbjct: 3671 EDFYRKLKGLNDATTAA--EEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3728
Query: 744 FQDAGH---------FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-V 793
G D + ++ E + AR+ L + + R +L ++L F+D +
Sbjct: 3729 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDAL 3788
Query: 794 EDEETWIREKEPIAASTNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE 852
E +W+ + E + A+ + V+ +++ + LQ + + + + +G + +
Sbjct: 3789 EPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ 3848
Query: 853 EGHFA-AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQQYFADANEAESWMREKE 910
A E + +L L +W L +KA+ R++ LED L A+Q+ A ++ E
Sbjct: 3849 SAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3908
Query: 911 P-IVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
+ S G + + +H+AL D+ + + + + QS +P +
Sbjct: 3909 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
Query: 970 ELVLALY----DYQEKSPREVTMKKG----------DILTLLNSTNKDWWKVEVNDRQGF 1015
E + +L + Q++ R+ + D + +LN W EV D+
Sbjct: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLN------WLAEVEDK--- 4019
Query: 1016 VPAAYVKKLDPAQSASRENLLEEQGS--IALRQEQIDNQTRITKEAGSVSLRMKQ----- 1068
+ + +VK ++++L Q + +AL +E ++ + + + + +KQ
Sbjct: 4020 LSSVFVKDF-------KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072
Query: 1069 ----------VEELYHSLLELGEKRKGMLEKSCKKFMLFREA-NELQQWINEKEAAL-TS 1116
++ Y + K LE++ + F+ EL W+ E E L TS
Sbjct: 4073 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132
Query: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
EQ+ Q++ + +K++ + L +N+V+ L ++ V
Sbjct: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL---------LELV------ 4177
Query: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA-HEV 1235
PW++ + V+ + NE+++ + +R + +A
Sbjct: 4178 --------------PWRAREGLDKLVS------DANEQYKLVSDTIGQRVDEIDAAIQRS 4217
Query: 1236 QRFHRDADETKEWIEE---KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSL 1292
Q++ + AD W+ E K AL D + Q +K F D+ D ++ L
Sbjct: 4218 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK--AFSIDIIRHKDSMDEL 4275
Query: 1293 GETAERLIQSHPESAED-LQEKCTELNQAWSSLGKRADQRKAKLGDSHDL-QRFLSDFRD 1350
+ + E + LQEK L Q + ++ +R A+L + L +F + +
Sbjct: 4276 FSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE 4335
Query: 1351 LMSWINGIRGLVSS--------DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402
L WI R L++ ++L + L E EH+ ID + G
Sbjct: 4336 LSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL-------KIG 4388
Query: 1403 QQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL----ELQLFHRDCEQAE 1458
QL +++K + A +++ QR + LD+ + ++ FH E
Sbjct: 4389 PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPML 4448
Query: 1459 NWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHY 1517
+ + L + +D + I ++ + + AL+ ++LI
Sbjct: 4449 ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4508
Query: 1518 AKGDISSRR-NEVLDR----WRRLKAQMIEKRSK-LGESQTLQQFSRDVDEIEAWISEKL 1571
A D++++ + LD+ W +KA+ E+ K L + ++F D+ + I +
Sbjct: 4509 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQ 4568
Query: 1572 QTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE 1631
D + I S + + + + + E + + + +G LI AC +E
Sbjct: 4569 DIVHD---LESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIF--ACGETE 4623
Query: 1632 DA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ--QNFNTGIKDFDFWLSEVEALLAS 1688
V+ + + + W+ L + E+ +KL++A + Q +T FD+ + V L
Sbjct: 4624 KPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4683
Query: 1689 EDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQ--VKDKRDT 1746
G DL +V + L + + + ++ + ++ LN Q + ++ + +T + +++
Sbjct: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743
Query: 1747 INGRFQKIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKE-KKLLVGSEDYGRDLTGV 1804
+ ++ + A R+ KL + L QF +++ SW+ ++LL D +
Sbjct: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4803
Query: 1805 QNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNT-IGKEEIQQRLAQFVEHWKELKQL 1863
+ KH L+ ++ AH+ ++ V G +L + + ++ RL + W+ + Q
Sbjct: 4804 EVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQK 4863
Query: 1864 AAARGQRLEESLEYQQ-FVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFE 1921
R Q+L+ +L+ Q F + +E+ + + L AS+ G + L H
Sbjct: 4864 TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4923
Query: 1922 TDFTVHKDRVNDVCTNGQDLI--KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE 1979
+ ++ N + G+ ++ + ++ + L K + +RK+KL+E
Sbjct: 4924 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4983
Query: 1980 N-SAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
+ +F +W+ E SL L++V + + + + F + A + +
Sbjct: 4984 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ- 5042
Query: 2038 IANITALKDQLLAAKHVQSKA-IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2096
I + +QL Q I+ S+ RW +++ S R + L +A+ ++ +
Sbjct: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102
Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDPVRC-NSLEEIKALREAHDAFRSSLSSAQADFNQL 2155
+ W E+AE L + N ++IK H F+ +L Q ++
Sbjct: 5103 AWKKLI-------DWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTT 5155
Query: 2156 AELDRQIKSFRVA---SNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR 2212
R +K + S F E + + W + ER Q + EE
Sbjct: 5156 IRTGRALKEKTLLPEDSQKLDNFLGE-VRDKWDTVCGKSVER-------QHKLEEALLFS 5207
Query: 2213 QEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIED 2272
+F A W+ + L + + + + + ++A K +E+ ++ ++
Sbjct: 5208 GQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 5267
Query: 2273 LGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQA----RNTTGVTEE 2328
G + E D + + L+ +WD + +L + Q LEQ ++ R+T + E
Sbjct: 5268 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327
Query: 2329 ALKE 2332
L E
Sbjct: 5328 WLSE 5331
Score = 250 bits (639), Expect = 1e-65
Identities = 420/2047 (20%), Positives = 846/2047 (41%), Gaps = 198/2047 (9%)
Query: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
P G + + +Q+ L+ R + KLE +F R+ + +
Sbjct: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
Query: 63 KLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD------ETGNLMISEGHFA 116
+L +D +LQ +++ + F ++ ++KLD E +++ EG
Sbjct: 3581 ELD-GMGAIGRDTDSLQSQIEDVRLFLNKIH-----VLKLDIEASEAECRHMLEEEGTLD 3634
Query: 117 SETIRTRLMELHRQWELLLE--KMREKGIKLL--QAQKLVQYLRECEDVMDWINDKEAIV 172
++ L L++Q L E K R++ ++L + + + L+ D + EA+
Sbjct: 3635 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL- 3693
Query: 173 TSEELGQDLEHVEVLQKKFEEFQTDMAAH-EERVNEVNQFAAKLIQEQHPEEEL--IKTK 229
+G ++E + F+ FQ + + ++ +VN LIQ + ++ ++
Sbjct: 3694 -QWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD 3752
Query: 230 QDEVNAAWQRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDL 287
+E+NA W L QR +L A +F ++ +SW+ + E+L+A+ +
Sbjct: 3753 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3812
Query: 288 ASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ-IQVKREELITNWEQI 346
V+A +++ + L+R L + V L AE R+ QS L+ + I + E L + W ++
Sbjct: 3813 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3872
Query: 347 RTLAAERHARLNDSYRLQRF-------LADFRDLTSWVTEMKALINADELASDVAGAEAL 399
+ AA R +L D L + ++DF +T K L N++ + + A +
Sbjct: 3873 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE-----KKLANSEPVGTQTAKIQQQ 3927
Query: 400 LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV-REKLTVLSEERAALLELWEL 458
+ RH+ + +I+ H A + GQ+L + A V EK+ L + + +
Sbjct: 3928 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987
Query: 459 RRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFL------------LNEDLGDSLDSVEAL 505
+ +Q + + +LF D +V NW+++ E L L+ D L E +
Sbjct: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047
Query: 506 LKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATR-RDALLSRRNALHERAMR 564
+ + ++ ++++ + + LIQ ++ + TR D ++ AL R +
Sbjct: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK---LDGIKTRYADITVTSSKAL--RTLE 4102
Query: 565 RRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKV--QKHQAFEAELS 622
+ QLA F +EL W+ E + + P+ Q Q+ + + E+
Sbjct: 4103 QARQLATKFQSTY-----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 4157
Query: 623 ANQSRIDALEKAGQKLIDVNHY-AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
++ +D + + + L+++ + A++ + +++ +K + + + ++ A Q+
Sbjct: 4158 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 4217
Query: 682 QFNRNVEDIEL-WLYEVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGI 737
Q D EL W+ E + L + +D T Q LQ + A D+ H+D +D +
Sbjct: 4218 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ-LQVQKAF-SIDIIRHKDSMDEL 4275
Query: 738 -TIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS-LRLQQLFRDVED 795
+ ++ F G +++K E+L+ +YEA+ R +L + + + Q + E+
Sbjct: 4276 FSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE 4335
Query: 796 EETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRI----------KAVT 844
WI E + A + D ++ ++ + L+ IA H+P I K +
Sbjct: 4336 LSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN 4395
Query: 845 QKGNAMVEEGHFAAEDVKAKL-HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE 903
+ MVEE + AE++ A++ E+ Q+ AL SQ Q E + +
Sbjct: 4396 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLS 4455
Query: 904 SWMREKEPIVGSTDYGK----DEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
S +R I D + D SA L+K + L G + L ++Q +
Sbjct: 4456 SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRG---EELIGRSQGADKD 4512
Query: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE-----VNDRQG 1014
+A + + + ++ ++ + E +K D+L L K W+ + + D Q
Sbjct: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLEL---AEKFWYDMAALLTTIKDTQD 4569
Query: 1015 FVPAAYVKKLDPA----QSASRENLLEEQGSIALRQEQIDNQTRIT----------KEAG 1060
V +DP+ Q + E + EE + E I RI E
Sbjct: 4570 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFI----RILGADLIFACGETEKP 4625
Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAAL-TSEE 1118
V + ++ + +L + ++R LE + + + +++ + W++ L T
Sbjct: 4626 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4685
Query: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGM 1178
VG DL V+ + +F+ ++ + ++ +N E LM ++
Sbjct: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE------LMLKKAT---------- 4729
Query: 1179 MPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQR 1237
DETD + EL W +L +++A + +L G+ + +
Sbjct: 4730 ---DETDRDIIR---------------EPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4771
Query: 1238 FHRDADETKEWIEEKNQALNTDN-YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETA 1296
F +E W+ + L+ D ++ KH + D+ A V ++ +
Sbjct: 4772 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4831
Query: 1297 ERLIQSHP-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSW 1354
L++S + A L+ + +NQ W S+ ++ ++R+ +L + Q F S+ D +
Sbjct: 4832 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891
Query: 1355 INGIRGLVSSDELAKDVTG-AEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GHY 1411
+ + +S+ + + A L+ H E +++ A+ T+ G+ +L
Sbjct: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951
Query: 1412 ASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNT 1470
+ + +Q + +L+Q+ + +R+ L++ L L F ++ NW+ E LN
Sbjct: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
Query: 1471 EDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRN-- 1527
L++V + I++H+ F +N ++I L +QL K D+ +N
Sbjct: 5012 ASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQ--KQDVVLIKNLL 5069
Query: 1528 -EVLDRWRRLKAQMIEKRSKLGESQT-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPT 1583
V RW ++ + IE+ L +++ +QF ++ W+ +E + E DP
Sbjct: 5070 VSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPD 5129
Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALAD 1643
I+L LSKH++ F+ L I G +L E+ + L + D
Sbjct: 5130 KIKLQ--LSKHKE---FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRD 5184
Query: 1644 QWQFLVQKSAEKSQKLKEANK-QQNFNTGIKDFDFWLSEVEALLASED--YGKDLASVNN 1700
+W + KS E+ KL+EA F ++ WL +VE LA + +G DL V N
Sbjct: 5185 KWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMN 5243
Query: 1701 LLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAAS 1760
L+ H++ + ++ ++ L L+ +S DT+ VK + ++ R+ + ++ S
Sbjct: 5244 LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVS 5303
Query: 1761 RRAKLNESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL 1818
++++L ++ + + FRD + W+ E ++ L D +Q+L HK ++
Sbjct: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363
Query: 1819 AAHEPAIQGVLDTGKKL-----SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
+ + G+ + D T K I A+F +E+ A QRLE
Sbjct: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARF----EEVLTWAKQHQQRLET 5419
Query: 1874 SLEYQQFVAN---VEEEEAWINEKMTLVASED---YGDTLAAIQGLLKKHEAFETDFTVH 1927
+L + VAN +EE AWI T + D + ++ L+ +H+ F + T
Sbjct: 5420 AL--SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRK 5477
Query: 1928 KDRVNDV 1934
+ V+ V
Sbjct: 5478 QPDVDRV 5484
Score = 188 bits (477), Expect = 6e-47
Identities = 443/2389 (18%), Positives = 917/2389 (38%), Gaps = 310/2389 (12%)
Query: 135 LEKMREKG-IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEE---LGQDLEHVEVLQKK 190
L++M ++ +K LQ Q+ + ++ ED+ W+ E + + QDL ++ Q
Sbjct: 2035 LQQMEQEALVKTLQKQQNTCH-QQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD 2093
Query: 191 FEEFQTDMAAH---------------EERVNEVNQFAAKLIQEQ-HPEEELIKTKQDEVN 234
++ Q D+ EE +++ ++E+ H +E + Q+E
Sbjct: 2094 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETR 2153
Query: 235 AAWQRLKGL---ALQRQGKLFGAA-EVQRFNRDVDETISWIKE--------------KEQ 276
A + L+ ALQ++ + AA E+ + +D + W+ EQ
Sbjct: 2154 VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ 2213
Query: 277 LMASDDFGRDLASVQALL---RKHEGLERDLAALEDKVKALCAEADRL------------ 321
L + L + + + E L++ ++ + + L ++
Sbjct: 2214 LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD 2273
Query: 322 QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY----RLQRFLADFRDLTSWV 377
Q H L+ + Q+ +++L EQ T A+ A L LQ+FL D ++ SW+
Sbjct: 2274 QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 2333
Query: 378 TEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL-------- 428
K L N + S +LL R ++ +H+ + SGQ +L
Sbjct: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393
Query: 429 -----AAGHYASDEVR---EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
G+ D+++ E+ T L + L + QY Q F + +
Sbjct: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQ------FQNSADSLQ 2447
Query: 481 NWMSKQEAF---LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN 537
WM EA LL++ + ++ L + ++ L+ + + L + A +++
Sbjct: 2448 AWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2507
Query: 538 HYAMED---VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK 594
D V D++LS +L R + L + Q ++S L+S + +
Sbjct: 2508 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES--LESLLQSIGE 2565
Query: 595 TATDEAYKDPSNLQ-GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA-- 651
+ K S+L G +Q+ A +L + +R + +A ++++ D A
Sbjct: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625
Query: 652 ---RMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVEDIELWLYEVEGHLASDDY- 706
++ EV +++L + K L++ Q + F ++ ++ LAS +
Sbjct: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQP 2685
Query: 707 GKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQFQDAG-------HFD-AENIKK 757
+D+T+ Q +Q+ L ++ Q+ +D + + G H D +N++K
Sbjct: 2686 DQDITHFFQQIQE----LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2741
Query: 758 KQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLI 817
L + ++ + +++L + +L + F + W++E E T
Sbjct: 2742 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTF------QKWLKETEGSIPPTETSMSAK 2795
Query: 818 GVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE------------------------- 852
++ ++ ++L + A ++ + KG ++
Sbjct: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2855
Query: 853 ---EGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESW 905
G+ +D ++ + ++N K+E L +R++ L+ L + ++ +AN W
Sbjct: 2856 GSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQW 2915
Query: 906 MREKEPIVGSTDYGKDEDSAE---ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP 962
+ KE ++ S D E A + ++A +++L IQ ++E
Sbjct: 2916 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA---------- 2965
Query: 963 TDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEV-NDRQGFVPAAYV 1021
L L Y E K I LNS + +V V RQ A+++
Sbjct: 2966 --------LAGLLVTYPNSQEAENWKK---IQEELNSRWERATEVTVARQRQLEESASHL 3014
Query: 1022 KKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGE 1081
A+S R L+E++ + + + + + V +K+ E +L E
Sbjct: 3015 ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074
Query: 1082 KRKGMLEKSCKKFMLFREANELQQWINEKEAALTSE--EVGADLEQVEVLQKKFDDFQKD 1139
+G+L + + + Q IN+K LT + + ++Q V ++ + +D
Sbjct: 3075 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQD 3134
Query: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ-----EVYGMMPRDETDSKTASPW-K 1193
L + + V + L + ++ + +AV+QQ E+ + + + + K A
Sbjct: 3135 LS------EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCD 3188
Query: 1194 SARLMVHTVATFNSIKELNER----WRSLQQLAEER-SQLLGSAHEVQRFHRDADETKEW 1248
+++ + +K+ E + L+ LA +R ++L + Q+F + DE + W
Sbjct: 3189 ELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW 3248
Query: 1249 IEEK-NQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP--E 1305
+++K +Q L +Q+ +++E F++ L + E L+ S P E
Sbjct: 3249 LDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGE 3308
Query: 1306 SAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIRGLVSS 1364
LQ + EL W L K+ R+++L D Q++ DL+ WI + +S
Sbjct: 3309 EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE 3368
Query: 1365 DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILD 1424
+ D E+ L R + E++ R + L+ D
Sbjct: 3369 LRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE------------AD 3416
Query: 1425 QERADLEKAWVQRRM-MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDS------- 1476
++ EKA + + M + + L+ + + E + +E+F N E K +
Sbjct: 3417 EDGIRDEKAGINQNMDAVTEELQAKTGSLE-EMTQRLREFQESFKNIEKKVEGAKHQLEI 3475
Query: 1477 LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQL--IAAGHYAKGDISSRRNEVLDRWR 1534
D++ + +++ +K + Q+E + AL+ D L G S +++L +
Sbjct: 3476 FDALGSQACSNKNLEK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAE 3534
Query: 1535 RLKAQMIEKRSKLGES-------------------QTLQQFSRDVDEIEAWISEKLQTAS 1575
+ + +E + ++ + Q + DE++ + T S
Sbjct: 3535 VAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDS 3594
Query: 1576 DESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVK 1635
+S + + L+K+ +A EAE + G +D+ E A +
Sbjct: 3595 LQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EGTLDLLGLKRELEALNKQCGKLT 3653
Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDL 1695
R A +Q + + + + +KLK G+ D E EAL G ++
Sbjct: 3654 ERGKARQEQLELTLGRVEDFYRKLK----------GLNDATTAAEEAEAL--QWVVGTEV 3701
Query: 1696 ASVNNLLKKHQLLEAD-ISAHEDRLKDLNSQADSLMTSSA--FDTSQVKDKRDTINGRFQ 1752
+N L ++ + + + + +L+ +N L+ S+ D ++ + IN R+
Sbjct: 3702 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3761
Query: 1753 KIKSMAASRRAKLNESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKK 1810
+ A R A+L E+ F+D ++ SW+ + ++L+ + + V+ ++
Sbjct: 3762 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3821
Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIG-KEEIQQRLAQFVEHWKELKQLAAARGQ 1869
K L+ L + + + G +++ + +E+I +L W EL AAAR +
Sbjct: 3822 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3881
Query: 1870 RLEESLEY-QQFVANVEEEEAWIN-EKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVH 1927
+LE+ L +QF E +++ + L SE G A IQ + +H+A E D H
Sbjct: 3882 QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENH 3941
Query: 1928 KDRVNDVCTNGQDLIKKNNHHEENI-SSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
V+ GQ L + E+ + S K+ L + S+++ ++ A LD+ + +
Sbjct: 3942 ATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL 4001
Query: 1987 NWKADV-VESWIGEKENSLKT---DDYGRDL---SSVQTLLTKQETFDAGLQAFQQEGIA 2039
+ +V V +W+ E E+ L + D+ +D+ L +E + + I
Sbjct: 4002 FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNV--DQAIK 4059
Query: 2040 NITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFL 2099
N AL Q + + I+ + + R++ + S+ + L +A+ L
Sbjct: 4060 NGQALLKQTTGEEVL---LIQEKLDGIKTRYADITVTSSKALRTLEQAR-------QLAT 4109
Query: 2100 TFAKKASAFNSWFENAEEDL-TDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAEL 2158
F W EE+L T + + E+I ++ + + + + + E+
Sbjct: 4110 KFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEV 4169
Query: 2159 DRQIKSFRVASNPYTWFTMEALE-------ETWRNLQKIIKERELELQKEQRRQEENDKL 2211
R + W E L+ E ++ + I +R E+ +R
Sbjct: 4170 SRALLEL------VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS------ 4217
Query: 2212 RQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKI- 2270
Q++ Q A+A W+ ET+ L+ + E +QL+ K +I + + ++
Sbjct: 4218 -QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELF 4276
Query: 2271 ----EDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQ 2315
E G EE + T L QQ++ + L LE+
Sbjct: 4277 SHRSEIFGTCGEE----QKTVLQEKTESLIQQYEAISLLNSERYARLER 4321
Score = 168 bits (425), Expect = 7e-41
Identities = 331/1803 (18%), Positives = 726/1803 (40%), Gaps = 216/1803 (11%)
Query: 9 LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRF-QFFQRDAEELEKWIQ--EKLQ 65
L E I + + + R+ + R+++LED + F AE + ++ EK
Sbjct: 3852 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3911
Query: 66 IASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125
S+ +Q ++ +H+A E +++ ++ + + + G + S A + + + +
Sbjct: 3912 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3971
Query: 126 E-LHRQWELLLEKMREKGIKLLQAQKLVQYLRECE-DVMDW---INDKEAIVTSEELGQD 180
+ L ++ + ++ K L QA + E E +V++W + DK + V ++ QD
Sbjct: 3972 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 4031
Query: 181 LEHVEVLQKKFEEFQTDMAAHEERVNE-------VNQFAAKLIQEQHPEEELIKTKQDEV 233
+ H + +A +EE VN + A L Q E LI+ K D +
Sbjct: 4032 VLH--------RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 4083
Query: 234 NAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETISWIKE-KEQLMASDDFGRDLASVQ 291
+ + + + L A ++ +F +E W++E +E+L S +
Sbjct: 4084 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIP 4143
Query: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
++ + L++++ + + + L + P A + ++L+++ + L +
Sbjct: 4144 QFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVS 4200
Query: 352 ERHARLNDSY-----RLQRFLADFRDLTSWVTEMKALINA--------DELASDVAGAEA 398
+ + D R Q++ +WV E K + A D+ + + +A
Sbjct: 4201 DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKA 4260
Query: 399 L---LDRHQEHKGEIDAHEDS-FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
+ RH++ E+ +H F + E + +L + + E +++L+ ER A LE
Sbjct: 4261 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 4320
Query: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514
++ Q F+ E++ W+ + A + L E L ++ E+ +
Sbjct: 4321 RAQVLVNQ---------FWETYEELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQ 4369
Query: 515 ---SLSAQEEKITALDEFATKLIQNNHYAMEDVATR----RDALLSRRNALHERAMRRRA 567
S++ + I L + +L + N E V + + + + +RA+
Sbjct: 4370 LRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDE 4429
Query: 568 QLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP------SNLQGKVQKHQAFEAEL 621
++ S + +F D+++ + E ++ + P ++ + +++ EL
Sbjct: 4430 AVSQSTQITEFH---DKIEPML-ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVEL 4485
Query: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAAR-----MNEVISLWKKLLEATELKGIKLRE 676
Q +AL++ G++LI + A ++AA+ +++++ W+ IK R
Sbjct: 4486 EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED---------IKARA 4536
Query: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN------------VQNLQKKHALLE 724
++ +F +E E + Y++ L + +D+ + Q ++ + E
Sbjct: 4537 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4596
Query: 725 ADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
H++ + A G + ++K + + +E L + R +KL D++
Sbjct: 4597 ETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAM 4656
Query: 785 RLQQLFRD-VEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
+ ++D ++ W+ + G DL V++ L + + + E+ + ++
Sbjct: 4657 QAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEK 4716
Query: 843 VTQKGNAMVEEGHFAAED--VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA- 899
+ +G M+++ + ++ L EL WE L K + R+ LE +L A F A
Sbjct: 4717 LNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHAL 4776
Query: 900 NEAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQ 958
E SW+ E ++ + D E L KH L +D+ A+ ++++ + + +
Sbjct: 4777 EELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLE 4836
Query: 959 QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE---------- 1008
A D + + + A+ E ++ ++ + + L ++E
Sbjct: 4837 SSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRME 4896
Query: 1009 ----VNDRQGFVPAAYVKKLDP-----AQSASRE---NLLEEQGSIALRQEQIDNQTRIT 1056
+ G +P ++LD +Q ++E N L ++G + L D+ +
Sbjct: 4897 SQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR--DDSGSGS 4954
Query: 1057 KEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
K SV+L +E+ +H + E+RK LE++ F+ N LQ++IN A S
Sbjct: 4955 KTEQSVAL----LEQKWHVVSSKMEERKSKLEEALNLATEFQ--NSLQEFINWLTLAEQS 5008
Query: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
+ + + +N V +E + A EV A + Q +
Sbjct: 5009 LNIASPPSLI-----------------------LNTVLSQIEEHKVFANEVNAHRDQII- 5044
Query: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHE-V 1235
E D +T + K V N + + RW + Q + ER + L A +
Sbjct: 5045 ------ELD-QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 5097
Query: 1236 QRFHRDADETKEWIEEKNQALNTD-NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGE 1294
++FH + +W+E+ L+++ +D ++ KH+ F++ L ++
Sbjct: 5098 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 5157
Query: 1295 TAERLIQSH--PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
T L + PE ++ L E+ W ++ ++ +R+ KL ++ +F+ + L
Sbjct: 5158 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 5217
Query: 1352 MSWINGIRGLVSSDE-LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
+ W+ + ++ D+ + D+ L++ H+ + E+ R GT Q ++ G++L+ +
Sbjct: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 5277
Query: 1411 YASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAFLN 1469
+ +K +L L + K V ++ L+Q L + ++F W++ E L
Sbjct: 5278 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337
Query: 1470 TEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGH--------YAKG 1520
D +++++LI H++F K + + + + A + ++A H +
Sbjct: 5338 FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWIT 5397
Query: 1521 DISSRRNEVLDRWRRLKAQMIEKR-SKLGESQTLQQFSRDVDEIEAWISEKLQTASDESY 1579
I +R EVL W + Q +E S+L + L ++E+ AWI + +T +
Sbjct: 5398 IIRARFEEVLT-WAKQHQQRLETALSELVANAEL------LEELLAWI-QWAETTLIQRD 5449
Query: 1580 KDPTNIQLSKLLSKHQKHQAFEAEL---HANADRIRGVIDMGN------SLIERGACAGS 1630
++P + ++ + +HQ F E+ + DR+ N IE+ G
Sbjct: 5450 QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR 5509
Query: 1631 E----------------DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKD 1674
+ +A R+ L+ +WQ + + E+ +KL +A + +
Sbjct: 5510 KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFAN 5569
Query: 1675 FDF 1677
FDF
Sbjct: 5570 FDF 5572
Score = 162 bits (410), Expect = 4e-39
Identities = 441/2392 (18%), Positives = 914/2392 (38%), Gaps = 286/2392 (11%)
Query: 54 EELEKWIQEKLQIASDENYKDPTNLQGKLQK--------HQAFEAEVQ----ANSGAIVK 101
E+L EK + + + Y KL K HQ ++ Q A A
Sbjct: 2212 EQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAF 2271
Query: 102 LDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMRE--KGIKLLQAQKLVQYLRECE 159
LD+ G+ + E + ++ +L EL Q+ L + K ++ LQ +L ++L++ +
Sbjct: 2272 LDQHGHNLTPE---EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ-DELQKFLQDHK 2327
Query: 160 DVMDWINDKEA-IVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE 218
+ W+ E + + G E + L K+ F D+ +H+ + V K++
Sbjct: 2328 EFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDM 2387
Query: 219 QHPEEE---------LIKTKQDEVNAAWQRLKGLALQRQGKL-FGAAEVQRFNRDVDETI 268
++ +E L+K K + + L + L + +F D
Sbjct: 2388 ENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQ 2447
Query: 269 SWIKEKE---QLMASDDFGRDLASVQALLRKHEGLERDLAALE---DKVKALCAEADRLQ 322
+W++ E + + SD D +Q L + L+ +LA + +K++ + + ++
Sbjct: 2448 AWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2507
Query: 323 QSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMK 381
+Q + ++++++ + AER + L + + Q L + E++
Sbjct: 2508 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2567
Query: 382 ALINADELASDVAGA-EALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVRE 440
+ +++S +G + L + + K +I + S ++ E + + V +
Sbjct: 2568 QNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQ 2627
Query: 441 -KLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN------- 492
KL +S+ +L QQ E+ L+ E ++ K + F+ N
Sbjct: 2628 GKLAEVSQR------FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2681
Query: 493 -----EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE--FATKLIQNNHYAMEDVA 545
+D+ ++ L + ED +++L E +T L FA L Q+ + V
Sbjct: 2682 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQ----DRVQ 2737
Query: 546 TRRDALLSRRNALHER---AMRRRAQLADSFHLQQFFR-----------------DSDEL 585
R + + ER A + QL + L + F+ + EL
Sbjct: 2738 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2797
Query: 586 KSWVNEKMKTATDEAYK----DPSNLQGKVQKHQAFEAELSANQSRIDA-LEKAGQKLID 640
+ + D A K + N +G ++ E +Q + + L G +
Sbjct: 2798 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2857
Query: 641 VN--HYAKD--EVAARMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVEDIELWLY 695
VN H KD E+ M++V ++KL + L+ N+ ++ ++ + WL
Sbjct: 2858 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2917
Query: 696 EVEGHLASDDYGKDLTNVQNLQ-----KKHALLEAD-----VAAHQDRIDGITIQARQFQ 745
E L S D T + ++ K L E + + ++ + G+ + Q
Sbjct: 2918 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2977
Query: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE-ETWIREKE 804
+A EN KK QE L +R+E E VAR+++L +S F+ E + W+ EKE
Sbjct: 2978 EA-----ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
Query: 805 -------PIAASTNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKA----VTQKGNAMVE 852
P++ N VQ +LK+ +A + + HE +A +T G+ +
Sbjct: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ---HEQLNEAAQGILTGPGDVSL- 3088
Query: 853 EGHFAAEDVKAKLHELNQKW----EALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
+ V+ +L +NQKW + L +++SQ Q + S Q Q+ D +E + +
Sbjct: 3089 ----STSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 3144
Query: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP--TDDE 966
+ + + ++ + L++ + SDL ++ + + DE
Sbjct: 3145 RLSV--QSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202
Query: 967 TGKEL---VLALYDYQEKSPREVTMKKGDILTLLNSTNK-----DWWKVEVNDRQG--FV 1016
K L L L ++ + + + L ST + D + ++D+Q
Sbjct: 3203 LKKRLETVALPLQGLEDLAADRINR----LQAALASTQQFQQMFDELRTWLDDKQSQQAK 3258
Query: 1017 PAAYVKKLDPAQSASREN------LLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVE 1070
KL+ QS +EN L + GS + + ++ Q+
Sbjct: 3259 NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLV 3318
Query: 1071 ELYHSLLELGEK---RKGMLEKSCKKFMLFR-EANELQQWINEKEAALTSEEVGADLEQV 1126
EL + EL +K R+ L+ +K ++ +L WI + +A ++ V D Q+
Sbjct: 3319 ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQL 3378
Query: 1127 EVLQKKFDDFQKDLKANESRLKDINKVAE------DLESEGLMAEEVQAVQQQEVYGMMP 1180
E + +++ S L+ +N A+ + + +G+ E+ Q +
Sbjct: 3379 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV---- 3434
Query: 1181 RDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEE-RSQLLGSAHEVQRFH 1239
+E +KT S++E+ +R R Q+ + ++ G+ H+++ F
Sbjct: 3435 TEELQAKT-----------------GSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF- 3476
Query: 1240 RDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERL 1299
D G S + L+ K + L AL +V+ L + L
Sbjct: 3477 -------------------DALGSQACSNKNLE-KLRAQQEVLQALEPQVDYLRNFTQGL 3516
Query: 1300 IQSHPE---------SAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSH-DLQRFLSDFR 1349
++ P+ AE Q++ E+ Q +S + + +G H ++ S
Sbjct: 3517 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLA 3576
Query: 1350 DLMSWINGIRGL-VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH 1408
DL ++G+ + +D L + L + + +I+A + L
Sbjct: 3577 DLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA------ECRHMLEEE 3630
Query: 1409 GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAEN-WMAAREA 1466
G +K++L+ L+++ L + R+ L+ L ++ F+R + + AA EA
Sbjct: 3631 GTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA 3690
Query: 1467 FLNTEDKGDSLDSVEALIKKHEDFDK-AINVQEEKIAALQAFADQLI--AAGHYAKGDIS 1523
G ++ + + + F K ++ + K+ + LI A +
Sbjct: 3691 EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE 3750
Query: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
E+ RW L ++ ++ ++L E+ L + D +E +S T + + P
Sbjct: 3751 HDMEEINARWNTLNKKVAQRIAQLQEA--LLHCGKFQDALEPLLSWLADTEELIANQKPP 3808
Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDM---GNSLIERGACAGSEDAVKARLAA 1640
+ + + ++ Q+ + + L D + +DM I + A + + +L +
Sbjct: 3809 SAEYKVVKAQIQEQKLLQRLL----DDRKATVDMLQAEGGRIAQSAELADREKITGQLES 3864
Query: 1641 LADQWQFLVQKSAEKSQKLKE-ANKQQNFNTGIKDFDFWLSEVEALLA-SEDYGKDLASV 1698
L +W L+ K+A + ++L++ + F+ + +LS E LA SE G A +
Sbjct: 3865 LESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKI 3924
Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQKIKSM 1757
+ +H+ LE DI H + SL + +S + + +K D++ R+ +I+
Sbjct: 3925 QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3984
Query: 1758 AASRRAKLNES-HRLHQFFRDMDDEESW---IKEKKLLVGSEDYGRDLTGVQNLRKKHKR 1813
+ A L+++ F D + +W +++K V +D+ +D+ Q+ H
Sbjct: 3985 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQH--ADHLA 4042
Query: 1814 LEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE--IQQRLAQFVEHWKELKQLAAARGQRL 1871
L E+ + + + G+ L T G+E IQ++L + ++ ++ + L
Sbjct: 4043 LNEEIVNRKKNVDQAIKNGQALLKQTT-GEEVLLIQEKLDGIKTRYADITVTSSKALRTL 4101
Query: 1872 EESLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHK- 1928
E++ + +F + EE W+ E + L S T I ++ + + + H+
Sbjct: 4102 EQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRL 4161
Query: 1929 --DRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN-SAFLQ 1985
D VN+V +L+ E + + N + + QR ++D Q
Sbjct: 4162 VLDTVNEVSRALLELVPW--RAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
Query: 1986 FNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ---AFQQEGIANIT 2042
+ AD +W+ E + R L ++ + +Q+ A LQ AF + I +
Sbjct: 4220 YEQAADAELAWVAETK---------RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKD 4270
Query: 2043 ALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFA 2102
++ + + E + L ++ L+ A E + + + L F
Sbjct: 4271 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 4330
Query: 2103 KKASAFNSWFENAEEDLTD-PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
+ + W E + P E+++ +E R S++ + ++L ++ Q
Sbjct: 4331 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 4390
Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQ----EENDKLRQEFAQ 2217
+K + E + +++ +++R L L + + E +DK+
Sbjct: 4391 LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLET 4450
Query: 2218 HANAFHQW---------IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEI 2260
N + + + R + D E L+ EA KR+ +E+
Sbjct: 4451 LENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEEL 4502
Score = 115 bits (289), Expect = 4e-25
Identities = 363/2064 (17%), Positives = 787/2064 (38%), Gaps = 342/2064 (16%)
Query: 445 LSEERAALLELWELRRQQYEQCMDLQL--FYRDTEQVDNWMSKQEAFLLNEDL-----GD 497
L + +++ + W R ++ ++++ Q++ + A++ N++L G
Sbjct: 1891 LQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGS 1950
Query: 498 S----LDSVEALLKKHEDFEKSLSAQEEKITAL--------DEFATKLIQNNHYAM---- 541
+ +DS+ L+++ED ++ ++ ++ ++ AL E A L + M
Sbjct: 1951 NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLL 2010
Query: 542 -----------EDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVN 590
E A + DAL + + A+ + Q + QQ ++L SWV
Sbjct: 2011 NELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQL----EDLCSWVG 2066
Query: 591 EKMK--------------TATDEAYKDPSNLQGKVQKH--------QAFEAELSANQSRI 628
+ + +A + D +LQ +Q + E + NQ+++
Sbjct: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL 2126
Query: 629 DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT----ELKGIKLREANQQQQFN 684
E L + H AK++ A E K+L EA + + K + A + +
Sbjct: 2127 SPRELTA--LREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENK 2184
Query: 685 RNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQ-------KKHALLEAD----------- 726
+ ++ + W+ V G+ LTN+ ++ +K AL D
Sbjct: 2185 KKIDALLDWVTSV-----GSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEK 2239
Query: 727 --------VAAHQDRIDG------ITIQARQFQDA-GH----FDAENIKKKQEALVARYE 767
A HQ+ + T A+ F D GH + + +++K L +Y
Sbjct: 2240 LDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYS 2299
Query: 768 ---ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNR-GKDLIGVQNLL 823
A E + + Q L D LQ+ +D ++ E+W+ E + ++ G + +LL
Sbjct: 2300 TSLAQSEAELKQVQTLQD--ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLL 2357
Query: 824 KKHQALQAEIAGHEPRIKAVTQKGNAMVE------EGHFAAED---VKAKLHELNQKWEA 874
K+ + ++ H+ ++ VT G +++ EG +E VK KL + +++ A
Sbjct: 2358 KRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTA 2417
Query: 875 LKAKASQRRQDLEDSL-QAQQYFADANEAESWMREKEPIVG---STDYGKDEDSAEALLK 930
L +K ++ L L Q Q+ A+ ++WM+ E V S D + L
Sbjct: 2418 LHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLA 2477
Query: 931 KHEALMSDLSAYGSSIQALREQAQSC----------RQQVAPTDDETGKELVLALYDYQE 980
+ L +L+ + ++ L++ A+ + V T D Y E
Sbjct: 2478 TTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE 2537
Query: 981 KSP--REVTMKKGDILTLLNSTNKDWWKVEVN---DRQGFVPAAYVKKLDPAQSASRENL 1035
+S ++ + + L S + +VE N + + + +++ ++++
Sbjct: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597
Query: 1036 LEEQGSIALRQEQIDN--QTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093
++ S+ +E + +T + A + ++ +V + + L ++++ L+K +
Sbjct: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQ 2657
Query: 1094 FMLFRE-ANELQQWINEKEAALTS-----EEVGADLEQVEVLQKKFDDFQKDLKANESRL 1147
+F + +LQQ++ K L S +++ +Q++ L + +D Q++L E +
Sbjct: 2658 AEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLV 2717
Query: 1148 KDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNS 1207
+++ L+ Q Q+
Sbjct: 2718 TELSSCGFALD----------LCQHQD--------------------------------R 2735
Query: 1208 IKELNERWRSLQQLAEERSQLLGSAHE-VQRFHRDADETKEWIEEKNQALNTDNYGHDLA 1266
++ L + + LQ+ +ER + S E + F + ++W++E ++
Sbjct: 2736 VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAK 2795
Query: 1267 SVQALQRKHEGFERDLAALG---DKVNSLGETAERLIQSHPESAEDLQEKC-TELNQAWS 1322
++ + D A+ G +++N G + E LI +A D Q K + L S
Sbjct: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME--ITAPDSQGKTGSILPSVGS 2853
Query: 1323 SLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQ 1382
S+G K D ++Q +SD + G+ L + +A+L R +
Sbjct: 2854 SVGSVNGYHTCK--DLTEIQCDMSDVNLKYEKLGGV--------LHERQESLQAILNRME 2903
Query: 1383 EHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE-IKQKLDILDQERADLEKAWVQRRMML 1441
E E ++ ++ E+ + + A E +K + + A+LE+ + + +
Sbjct: 2904 EVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVK 2963
Query: 1442 DQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKI 1501
+ L + + + ++AENW +E + ++ + E + + +++ + +
Sbjct: 2964 EALAGLLVTYPNSQEAENWKKIQEELNSRWER-----ATEVTVARQRQLEESAS----HL 3014
Query: 1502 AALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVD 1561
A QA Q L+ ++EK +G L S D +
Sbjct: 3015 ACFQAAESQ-------------------------LRPWLMEKELMMG---VLGPLSIDPN 3046
Query: 1562 EIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSL 1621
+ A K L + ++ Q+H+ +L+ A I L
Sbjct: 3047 MLNA-------------QKQQVQFMLKEFEARRQQHE----QLNEAAQGI---------L 3080
Query: 1622 IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLS 1680
G + S V+ L ++ +W L K +S ++ +A K + ++D +
Sbjct: 3081 TGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVR 3140
Query: 1681 EV-EALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQAD--SLMTSSAFDT 1737
V + L +V L++ + +D+ + +K+ + D S++ +
Sbjct: 3141 AVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200
Query: 1738 SQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDE-ESWIKEKKLLVGSE- 1795
++K + +T+ Q ++ +AA R +L + Q F+ M DE +W+ +K+
Sbjct: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260
Query: 1796 DYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE--IQQRLAQF 1853
L +Q+ ++++ + L H + + ++ G+ L G+E+ +Q +L +
Sbjct: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320
Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQG 1912
HW+EL + A R RL++ ++ Q++ +VE+ WI + ++ ++
Sbjct: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLES 3380
Query: 1913 LLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQ 1972
L + +A + + + + + LI + E+ I + G+N + + +
Sbjct: 3381 SLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQA 3440
Query: 1973 RKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA-GLQ 2031
+ L+E + L+ E + S K + V+ + E FDA G Q
Sbjct: 3441 KTGSLEEMTQRLR-------------EFQESFKNIE-----KKVEGAKHQLEIFDALGSQ 3482
Query: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
A + + + A ++ L +A+E + ++ ++Q L A +
Sbjct: 3483 ACSNKNLEKLRAQQEVL--------QALEPQ-VDYLRNFTQGLVEDAPDGSDASQLLHQA 3533
Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQAD 2151
+ FL ++ ++ EN E + C E L + D L A
Sbjct: 3534 EVAQQEFLEVKQRVNSGCVMMENKLEGI-GQFHCRVREMFSQLADLDD----ELDGMGAI 3588
Query: 2152 FNQLAELDRQIKSFRVASNP--YTWFTMEALEETWRN-------LQKIIKERELE-LQKE 2201
L QI+ R+ N +EA E R+ L + +RELE L K+
Sbjct: 3589 GRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ 3648
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLE----SQLEATKR-- 2255
+ E K RQE + + L D + EE+ L+ +++E +
Sbjct: 3649 CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQL 3708
Query: 2256 ------KHQEIRAMRSQLKKIEDLGAAMEEAL--ILDNKYTEHSTVGLAQQWDQLDQLGM 2307
+ +++ ++ +L+++ LG + ++ D + EH + +W+ L++
Sbjct: 3709 ADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK--- 3765
Query: 2308 RMQHNLEQQIQARNTTGVTEEALK 2331
++ + Q +A G ++AL+
Sbjct: 3766 KVAQRIAQLQEALLHCGKFQDALE 3789
Score = 95.9 bits (237), Expect = 4e-19
Identities = 332/1813 (18%), Positives = 689/1813 (38%), Gaps = 256/1813 (14%)
Query: 710 LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEAL 769
L N++ K+ LE ++A QD + + R+ +D ++ ++ + ++++ + +
Sbjct: 1817 LRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEV 1876
Query: 770 KEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNL--LKKHQ 827
++ +K D+ LQ+ V D TW L+ QN ++K +
Sbjct: 1877 PAQLLKALEK--DAKNLQKSLSSVSD--TW-------------NSRLLHFQNAVEIEKTK 1919
Query: 828 ALQ--AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQD 885
L ++ G ++A N ++ +E L+ Q++E LK ++R+
Sbjct: 1920 VLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQ 1979
Query: 886 LEDSLQAQQYFADANEAESWMREKEPIVGSTD--YGKDEDSAEALLKKHEALMSDLSAYG 943
L+ Q+F + + ++ ++ + +D E + +AL L
Sbjct: 1980 LDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQME 2039
Query: 944 SS--IQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPRE----VTMKKGDILTLL 997
++ L++Q +C QQ+ G + AL +Q ++ ++ + + D+ L
Sbjct: 2040 QEALVKTLQKQQNTCHQQLEDLCSWVG-QAERALAGHQGRTTQQDLSALQKNQSDLKDLQ 2098
Query: 998 NSTNK--DWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRI 1055
+ + V D +GF+ K +A RE L + + + E + +TR+
Sbjct: 2099 DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE----QYEALQEETRV 2154
Query: 1056 TKEAGSVSLRMKQVEELYHSLLELG-EKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
+ K++EE S L+ EK K E + K ++ + L W+
Sbjct: 2155 AQ---------KELEEAVTSALQQETEKSKAAKELAENK----KKIDALLDWVTS--VGS 2199
Query: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES--EGLMAEEVQAVQQ 1172
+ ++ +L +E L +K +N+ E L+ E + A + + Q
Sbjct: 2200 SGGQLLTNLPGMEQLSGA--SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQ 2257
Query: 1173 QEVYGMMPRD-----ETDSKTASPWKSARLMVHTVATFNSIKELNERWR-SLQQLAEERS 1226
Q+ + + + + +P + L + EL E++ SL Q E
Sbjct: 2258 QQNFILATQSAQAFLDQHGHNLTPEEQQMLQ-------QKLGELKEQYSTSLAQSEAELK 2310
Query: 1227 QLLGSAHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQRK----------H 1275
Q+ E+Q+F +D E + W+E + L N G ++ +L ++ H
Sbjct: 2311 QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISH 2370
Query: 1276 EGFERDLAALGDKVNSL------GETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRAD 1329
+G R + G KV + G+ + + +D E+ T L+ + LG +
Sbjct: 2371 KGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLN 2430
Query: 1330 QRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS---SDELAKD-------VTGAEALLE 1379
LG H +F + L +W+ V SD +A D + + L E
Sbjct: 2431 M---LLGQYH---QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQE 2484
Query: 1380 RHQEHRTEID-ARAGTFQAFEQFGQQLLAHGHYASPEIK-----QKLDILDQERADLEKA 1433
EH+ ++ + E G+ H H Q L ER+ L +
Sbjct: 2485 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2544
Query: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDK- 1492
+ + + + LE L + + E + ++ +++ G +++ +K +D +
Sbjct: 2545 AIAQSQSVQESLESLL--QSIGEVEQNLEGKQ--VSSLSSGVIQEALATNMKLKQDIARQ 2600
Query: 1493 --AINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGE- 1549
++ E + AD AA + + EV R+ +L Q EK S L +
Sbjct: 2601 KSSLEATREMVTRFMETADSTTAA------VLQGKLAEVSQRFEQLCLQQQEKESSLKKL 2654
Query: 1550 SQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANAD 1609
+ F +++ ++ K + + + D + Q+ Q E+ D
Sbjct: 2655 LPQAEMFEHLSGKLQQFMENKSRMLASGNQPD------QDITHFFQQIQELNLEME---D 2705
Query: 1610 RIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ---- 1665
+ + + + + E +C + D L D+ Q L + E + +KE K
Sbjct: 2706 QQENLDTLEHLVTELSSCGFALD-----LCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760
Query: 1666 ----QNFNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLL----KKHQLLE- 1709
F ++ F WL E E +++++ K + + +LL K L+E
Sbjct: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820
Query: 1710 ------------ADISAHEDRLKD---LNSQADSLMTSSAF----DTSQVKDKRDTINGR 1750
+I+A + + K L S S+ + + + D ++++ +N +
Sbjct: 2821 INCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2880
Query: 1751 FQKIKSMAASRRAKLNE-SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLR- 1808
++K+ + R+ L +R+ + ++ + W++ K+ ++ S D T + ++
Sbjct: 2881 YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA 2940
Query: 1809 --KKHKRLEAELAAHEPAIQGVLD--TGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLA 1864
+ +K AEL + P IQ V + G ++ N+ E ++ + W+ ++
Sbjct: 2941 QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVT 3000
Query: 1865 AARGQRLEESLEYQQ-FVANVEEEEAWINEKMTLVA-----SEDYGDTLA---AIQGLLK 1915
AR ++LEES + F A + W+ EK ++ S D A +Q +LK
Sbjct: 3001 VARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK 3060
Query: 1916 KHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISS-------KMKGLNGKVSDLEK 1968
+ EA + + T D+ + ++ + S LN + S +++
Sbjct: 3061 EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 3120
Query: 1969 A---AAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLK-----TDDYGRDLSSVQTLL 2020
A + Q + L + S ++ + V+S I + ++K T + DL + +
Sbjct: 3121 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 3180
Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
+ +T L E LKD+L K +++ A+ ++ L A+ R
Sbjct: 3181 KEAQTLCDELSVLIGE-----QYLKDEL--KKRLETVALP------LQGLEDLAADRINR 3227
Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
+ L + F+++ D T+ + +++ P+ LE +++ + ++
Sbjct: 3228 LQAALASTQQFQQMFDELRTWLDD--------KQSQQAKNCPISA-KLERLQSQLQENEE 3278
Query: 2141 FRSSLSSAQADFNQL-AELDRQIKSFRVASNPYTWFT-MEALEETWRNLQKIIKERELEL 2198
F+ SL+ + + AE + + S T + L+ W L K +R
Sbjct: 3279 FQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR---- 3334
Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
Q R ++ + Q++ H WI++ + + + ++ LES L +K
Sbjct: 3335 ---QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSKAMLN 3390
Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQ 2318
E+ RS L+ + + + D G+ Q D + +++Q
Sbjct: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDA-----------VTEELQ 3439
Query: 2319 ARNTTGVTEE---ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPE 2375
A+ TG EE L+EF FK+ +K G + E L S +E+ E
Sbjct: 3440 AK--TGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQE 3497
Query: 2376 FEAILDTVDPNRD 2388
+L ++P D
Sbjct: 3498 ---VLQALEPQVD 3507
Score = 70.9 bits (172), Expect = 2e-11
Identities = 91/435 (20%), Positives = 178/435 (40%), Gaps = 37/435 (8%)
Query: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIA 67
E ++ + +V D++ S R+ KLE++ F DA + L W+ + + Q+A
Sbjct: 5170 EDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLA 5229
Query: 68 SDENYKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLME 126
D+ +L + H+ F+ E+ +G + L +G +I + ++ +L E
Sbjct: 5230 EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 5289
Query: 127 LHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVM-DWINDKEAIVTSE-ELGQDLEHV 184
L +W+ + + K +L QA K + R+ ++ +W+++ E + L D E +
Sbjct: 5290 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEAL 5349
Query: 185 EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPE-EELIKTKQDEVNAAWQRLKGL 243
+ L +EF + VN ++ HP+ IK + A ++ +
Sbjct: 5350 QSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTW 5409
Query: 244 ALQRQGKLFGAAEVQRFNRDV-DETISWIKEKEQLMASDD---FGRDLASVQALLRKHEG 299
A Q Q +L A N ++ +E ++WI+ E + D +++ V+AL+ +H+
Sbjct: 5410 AKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQT 5469
Query: 300 LERDLAALEDKVKALCAEADR---------------------LQQSHP-----LSATQIQ 333
++ + V + R L Q P LS ++ +
Sbjct: 5470 FMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAK 5529
Query: 334 VKR-EELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASD 392
R +L W+Q+ LA ER +LND+ L +F + V K + + S
Sbjct: 5530 NPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSR 5589
Query: 393 VAGAEALLDRHQEHK 407
V +D+ Q+ K
Sbjct: 5590 VMDFFRRIDKDQDGK 5604
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 258 bits (658), Expect = 7e-68
Identities = 473/2464 (19%), Positives = 982/2464 (39%), Gaps = 250/2464 (10%)
Query: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY-RFQFFQRDAEELEKWIQEK--LQI 66
+ AE+ ++ ++++ R+ R E++ R+++LE+S FQ +L W+ EK +
Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 2534
Query: 67 ASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTR 123
DP L + Q+ Q E +A +L+E +++ + ++ ++
Sbjct: 2535 VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKE 2594
Query: 124 LMELHRQWELLLEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSE 175
L ++++W L +K+ + +K Q Q+L+Q L E V ++ + AI T
Sbjct: 2595 LQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQP 2654
Query: 176 E-LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234
E + Q LE ++ E+ ++ + +E++ LI EQ+ ++EL K + + V
Sbjct: 2655 EAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV----LIGEQYLKDEL-KKRLETVA 2709
Query: 235 AAWQRLKGLALQRQGKLFGA-AEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQA 292
Q L+ LA R +L A A Q+F + DE +W+ +K+ A + L +Q+
Sbjct: 2710 LPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQS 2769
Query: 293 LLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ--IQVKREELITNWEQIRTLA 350
L+++E ++ L + + AE + L S P + +Q + EL +WE++
Sbjct: 2770 QLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 2829
Query: 351 AERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGE 409
A+R +RL D + Q++ DL W+ + KA ++ + D E+ L R + E
Sbjct: 2830 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE 2889
Query: 410 IDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDL 469
++ + + + L+ + D +R++ +++ A+ E + + E+
Sbjct: 2890 VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMT-- 2947
Query: 470 QLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEF 529
Q E N K E ++ D+L S K E L AQ+E + AL+
Sbjct: 2948 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE----KLRAQQEVLQALEPQ 3003
Query: 530 ATKLIQNNHYAMEDVATRRDA--LLSRRNALHERAMRRRAQL-ADSFHLQQFFRDSDELK 586
L +ED DA LL + + + + ++ + ++ +
Sbjct: 3004 VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFH 3063
Query: 587 SWVNEKMKTATD---------EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
V E D +D +LQ +++ + F ++ + I+A E
Sbjct: 3064 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA---- 3119
Query: 638 LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEV 697
+ H ++E +++ L K+ LEA + KL E + +Q E +EL L V
Sbjct: 3120 --ECRHMLEEEGTL---DLLGL-KRELEALNKQCGKLTERGKARQ-----EQLELTLGRV 3168
Query: 698 EGHLASDDYGKDLTNVQNLQKKHAL-----LEADVAAHQ---------DRIDGITIQARQ 743
E D T ++ AL E ++ Q +++D + ++ +Q
Sbjct: 3169 EDFYRKLKGLNDATTAA--EEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3226
Query: 744 FQDAGH---------FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-V 793
G D + ++ E + AR+ L + + R +L ++L F+D +
Sbjct: 3227 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDAL 3286
Query: 794 EDEETWIREKEPIAASTNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE 852
E +W+ + E + A+ + V+ +++ + LQ + + + + +G + +
Sbjct: 3287 EPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ 3346
Query: 853 EGHFA-AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQQYFADANEAESWMREKE 910
A E + +L L +W L +KA+ R++ LED L A+Q+ A ++ E
Sbjct: 3347 SAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3406
Query: 911 P-IVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
+ S G + + +H+AL D+ + + + + QS +P +
Sbjct: 3407 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3466
Query: 970 ELVLALY----DYQEKSPREVTMKKG----------DILTLLNSTNKDWWKVEVNDRQGF 1015
E + +L + Q++ R+ + D + +LN W EV D+
Sbjct: 3467 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLN------WLAEVEDK--- 3517
Query: 1016 VPAAYVKKLDPAQSASRENLLEEQGS--IALRQEQIDNQTRITKEAGSVSLRMKQ----- 1068
+ + +VK ++++L Q + +AL +E ++ + + + + +KQ
Sbjct: 3518 LSSVFVKDF-------KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 3570
Query: 1069 ----------VEELYHSLLELGEKRKGMLEKSCKKFMLFREA-NELQQWINEKEAAL-TS 1116
++ Y + K LE++ + F+ EL W+ E E L TS
Sbjct: 3571 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 3630
Query: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
EQ+ Q++ + +K++ + L +N+V+ L ++ V
Sbjct: 3631 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL---------LELV------ 3675
Query: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA-HEV 1235
PW++ + V+ + NE+++ + +R + +A
Sbjct: 3676 --------------PWRAREGLDKLVS------DANEQYKLVSDTIGQRVDEIDAAIQRS 3715
Query: 1236 QRFHRDADETKEWIEE---KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSL 1292
Q++ + AD W+ E K AL D + Q +K F D+ D ++ L
Sbjct: 3716 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK--AFSIDIIRHKDSMDEL 3773
Query: 1293 GETAERLIQSHPESAED-LQEKCTELNQAWSSLGKRADQRKAKLGDSHDL-QRFLSDFRD 1350
+ + E + LQEK L Q + ++ +R A+L + L +F + +
Sbjct: 3774 FSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE 3833
Query: 1351 LMSWINGIRGLVSS--------DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402
L WI R L++ ++L + L E EH+ ID + G
Sbjct: 3834 LSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL-------KIG 3886
Query: 1403 QQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL----ELQLFHRDCEQAE 1458
QL +++K + A +++ QR + LD+ + ++ FH E
Sbjct: 3887 PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPML 3946
Query: 1459 NWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHY 1517
+ + L + +D + I ++ + + AL+ ++LI
Sbjct: 3947 ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006
Query: 1518 AKGDISSRR-NEVLDR----WRRLKAQMIEKRSK-LGESQTLQQFSRDVDEIEAWISEKL 1571
A D++++ + LD+ W +KA+ E+ K L + ++F D+ + I +
Sbjct: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQ 4066
Query: 1572 QTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE 1631
D + I S + + + + + E + + + +G LI AC +E
Sbjct: 4067 DIVHD---LESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIF--ACGETE 4121
Query: 1632 DA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ--QNFNTGIKDFDFWLSEVEALLAS 1688
V+ + + + W+ L + E+ +KL++A + Q +T FD+ + V L
Sbjct: 4122 KPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4181
Query: 1689 EDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQ--VKDKRDT 1746
G DL +V + L + + + ++ + ++ LN Q + ++ + +T + +++
Sbjct: 4182 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4241
Query: 1747 INGRFQKIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKE-KKLLVGSEDYGRDLTGV 1804
+ ++ + A R+ KL + L QF +++ SW+ ++LL D +
Sbjct: 4242 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4301
Query: 1805 QNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNT-IGKEEIQQRLAQFVEHWKELKQL 1863
+ KH L+ ++ AH+ ++ V G +L + + ++ RL + W+ + Q
Sbjct: 4302 EVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQK 4361
Query: 1864 AAARGQRLEESLEYQQ-FVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFE 1921
R Q+L+ +L+ Q F + +E+ + + L AS+ G + L H
Sbjct: 4362 TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4421
Query: 1922 TDFTVHKDRVNDVCTNGQDLI--KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE 1979
+ ++ N + G+ ++ + ++ + L K + +RK+KL+E
Sbjct: 4422 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4481
Query: 1980 N-SAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
+ +F +W+ E SL L++V + + + + F + A + +
Sbjct: 4482 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ- 4540
Query: 2038 IANITALKDQLLAAKHVQSKA-IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2096
I + +QL Q I+ S+ RW +++ S R + L +A+ ++ +
Sbjct: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 4600
Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDPVRC-NSLEEIKALREAHDAFRSSLSSAQADFNQL 2155
+ W E+AE L + N ++IK H F+ +L Q ++
Sbjct: 4601 AWKKLI-------DWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTT 4653
Query: 2156 AELDRQIKSFRVA---SNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR 2212
R +K + S F E + + W + ER Q + EE
Sbjct: 4654 IRTGRALKEKTLLPEDSQKLDNFLGE-VRDKWDTVCGKSVER-------QHKLEEALLFS 4705
Query: 2213 QEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIED 2272
+F A W+ + L + + + + + ++A K +E+ ++ ++
Sbjct: 4706 GQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 4765
Query: 2273 LGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQA----RNTTGVTEE 2328
G + E D + + L+ +WD + +L + Q LEQ ++ R+T + E
Sbjct: 4766 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 4825
Query: 2329 ALKE 2332
L E
Sbjct: 4826 WLSE 4829
Score = 250 bits (639), Expect = 1e-65
Identities = 420/2047 (20%), Positives = 846/2047 (41%), Gaps = 198/2047 (9%)
Query: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
P G + + +Q+ L+ R + KLE +F R+ + +
Sbjct: 3019 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3078
Query: 63 KLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD------ETGNLMISEGHFA 116
+L +D +LQ +++ + F ++ ++KLD E +++ EG
Sbjct: 3079 ELD-GMGAIGRDTDSLQSQIEDVRLFLNKIH-----VLKLDIEASEAECRHMLEEEGTLD 3132
Query: 117 SETIRTRLMELHRQWELLLE--KMREKGIKLL--QAQKLVQYLRECEDVMDWINDKEAIV 172
++ L L++Q L E K R++ ++L + + + L+ D + EA+
Sbjct: 3133 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL- 3191
Query: 173 TSEELGQDLEHVEVLQKKFEEFQTDMAAH-EERVNEVNQFAAKLIQEQHPEEEL--IKTK 229
+G ++E + F+ FQ + + ++ +VN LIQ + ++ ++
Sbjct: 3192 -QWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD 3250
Query: 230 QDEVNAAWQRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDL 287
+E+NA W L QR +L A +F ++ +SW+ + E+L+A+ +
Sbjct: 3251 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3310
Query: 288 ASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ-IQVKREELITNWEQI 346
V+A +++ + L+R L + V L AE R+ QS L+ + I + E L + W ++
Sbjct: 3311 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3370
Query: 347 RTLAAERHARLNDSYRLQRF-------LADFRDLTSWVTEMKALINADELASDVAGAEAL 399
+ AA R +L D L + ++DF +T K L N++ + + A +
Sbjct: 3371 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE-----KKLANSEPVGTQTAKIQQQ 3425
Query: 400 LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV-REKLTVLSEERAALLELWEL 458
+ RH+ + +I+ H A + GQ+L + A V EK+ L + + +
Sbjct: 3426 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3485
Query: 459 RRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFL------------LNEDLGDSLDSVEAL 505
+ +Q + + +LF D +V NW+++ E L L+ D L E +
Sbjct: 3486 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 3545
Query: 506 LKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATR-RDALLSRRNALHERAMR 564
+ + ++ ++++ + + LIQ ++ + TR D ++ AL R +
Sbjct: 3546 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK---LDGIKTRYADITVTSSKAL--RTLE 3600
Query: 565 RRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKV--QKHQAFEAELS 622
+ QLA F +EL W+ E + + P+ Q Q+ + + E+
Sbjct: 3601 QARQLATKFQSTY-----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 3655
Query: 623 ANQSRIDALEKAGQKLIDVNHY-AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
++ +D + + + L+++ + A++ + +++ +K + + + ++ A Q+
Sbjct: 3656 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 3715
Query: 682 QFNRNVEDIEL-WLYEVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGI 737
Q D EL W+ E + L + +D T Q LQ + A D+ H+D +D +
Sbjct: 3716 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ-LQVQKAF-SIDIIRHKDSMDEL 3773
Query: 738 -TIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS-LRLQQLFRDVED 795
+ ++ F G +++K E+L+ +YEA+ R +L + + + Q + E+
Sbjct: 3774 FSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE 3833
Query: 796 EETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRI----------KAVT 844
WI E + A + D ++ ++ + L+ IA H+P I K +
Sbjct: 3834 LSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN 3893
Query: 845 QKGNAMVEEGHFAAEDVKAKL-HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE 903
+ MVEE + AE++ A++ E+ Q+ AL SQ Q E + +
Sbjct: 3894 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLS 3953
Query: 904 SWMREKEPIVGSTDYGK----DEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
S +R I D + D SA L+K + L G + L ++Q +
Sbjct: 3954 SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRG---EELIGRSQGADKD 4010
Query: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE-----VNDRQG 1014
+A + + + ++ ++ + E +K D+L L K W+ + + D Q
Sbjct: 4011 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLEL---AEKFWYDMAALLTTIKDTQD 4067
Query: 1015 FVPAAYVKKLDPA----QSASRENLLEEQGSIALRQEQIDNQTRIT----------KEAG 1060
V +DP+ Q + E + EE + E I RI E
Sbjct: 4068 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFI----RILGADLIFACGETEKP 4123
Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAAL-TSEE 1118
V + ++ + +L + ++R LE + + + +++ + W++ L T
Sbjct: 4124 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183
Query: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGM 1178
VG DL V+ + +F+ ++ + ++ +N E LM ++
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE------LMLKKAT---------- 4227
Query: 1179 MPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQR 1237
DETD + EL W +L +++A + +L G+ + +
Sbjct: 4228 ---DETDRDIIR---------------EPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4269
Query: 1238 FHRDADETKEWIEEKNQALNTDN-YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETA 1296
F +E W+ + L+ D ++ KH + D+ A V ++ +
Sbjct: 4270 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4329
Query: 1297 ERLIQSHP-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSW 1354
L++S + A L+ + +NQ W S+ ++ ++R+ +L + Q F S+ D +
Sbjct: 4330 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389
Query: 1355 INGIRGLVSSDELAKDVTG-AEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GHY 1411
+ + +S+ + + A L+ H E +++ A+ T+ G+ +L
Sbjct: 4390 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4449
Query: 1412 ASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNT 1470
+ + +Q + +L+Q+ + +R+ L++ L L F ++ NW+ E LN
Sbjct: 4450 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 4509
Query: 1471 EDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRN-- 1527
L++V + I++H+ F +N ++I L +QL K D+ +N
Sbjct: 4510 ASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQ--KQDVVLIKNLL 4567
Query: 1528 -EVLDRWRRLKAQMIEKRSKLGESQT-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPT 1583
V RW ++ + IE+ L +++ +QF ++ W+ +E + E DP
Sbjct: 4568 VSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPD 4627
Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALAD 1643
I+L LSKH++ F+ L I G +L E+ + L + D
Sbjct: 4628 KIKLQ--LSKHKE---FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRD 4682
Query: 1644 QWQFLVQKSAEKSQKLKEANK-QQNFNTGIKDFDFWLSEVEALLASED--YGKDLASVNN 1700
+W + KS E+ KL+EA F ++ WL +VE LA + +G DL V N
Sbjct: 4683 KWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMN 4741
Query: 1701 LLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAAS 1760
L+ H++ + ++ ++ L L+ +S DT+ VK + ++ R+ + ++ S
Sbjct: 4742 LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVS 4801
Query: 1761 RRAKLNESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL 1818
++++L ++ + + FRD + W+ E ++ L D +Q+L HK ++
Sbjct: 4802 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 4861
Query: 1819 AAHEPAIQGVLDTGKKL-----SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
+ + G+ + D T K I A+F +E+ A QRLE
Sbjct: 4862 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARF----EEVLTWAKQHQQRLET 4917
Query: 1874 SLEYQQFVAN---VEEEEAWINEKMTLVASED---YGDTLAAIQGLLKKHEAFETDFTVH 1927
+L + VAN +EE AWI T + D + ++ L+ +H+ F + T
Sbjct: 4918 AL--SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRK 4975
Query: 1928 KDRVNDV 1934
+ V+ V
Sbjct: 4976 QPDVDRV 4982
Score = 191 bits (486), Expect = 6e-48
Identities = 467/2555 (18%), Positives = 973/2555 (38%), Gaps = 354/2555 (13%)
Query: 7 KVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI 66
++L +++ I + + RY L+T + + D+ R EE EK ++E+ Q
Sbjct: 1373 RMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALR------RLEEEEKVVEEEKQE 1426
Query: 67 ----------------------ASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDE 104
A+ K+ T+++ + + Q E+ + + +
Sbjct: 1427 HVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIK 1486
Query: 105 TGNLMISE-GHFASETIRTRLME----------------LHRQWELLLEKMREKGIKLLQ 147
T + +++ GH SE + ++ E ++ +L + + K LQ
Sbjct: 1487 TSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQ 1546
Query: 148 AQKLVQYLRECEDVMDWINDKEAIVTSEE---LGQDLEHVEVLQKKFEEFQTDMAAH--- 201
Q+ + ++ ED+ W+ E + + QDL ++ Q ++ Q D+
Sbjct: 1547 KQQNTCH-QQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATS 1605
Query: 202 ------------EERVNEVNQFAAKLIQEQ-HPEEELIKTKQDEVNAAWQRLKGL---AL 245
EE +++ ++E+ H +E + Q+E A + L+ AL
Sbjct: 1606 FATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSAL 1665
Query: 246 QRQGKLFGAA-EVQRFNRDVDETISWIKE--------------KEQLMASDDFGRDLASV 290
Q++ + AA E+ + +D + W+ EQL + L +
Sbjct: 1666 QQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTT 1725
Query: 291 QALL---RKHEGLERDLAALEDKVKALCAEADRL------------QQSHPLSATQIQVK 335
+ + E L++ ++ + + L ++ Q H L+ + Q+
Sbjct: 1726 DGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML 1785
Query: 336 REELITNWEQIRTLAAERHARLNDSY----RLQRFLADFRDLTSWVTEM-KALINADELA 390
+++L EQ T A+ A L LQ+FL D ++ SW+ K L N +
Sbjct: 1786 QQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGG 1845
Query: 391 SDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL-------------AAGHYASDE 437
S +LL R ++ +H+ + SGQ +L G+ D+
Sbjct: 1846 SSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK 1905
Query: 438 VR---EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF---LL 491
++ E+ T L + L + QY Q F + + WM EA LL
Sbjct: 1906 LKDATERYTALHSKCTRLGSHLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLL 1959
Query: 492 NEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED---VATRR 548
++ + ++ L + ++ L+ + + L + A +++ D V
Sbjct: 1960 SDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETT 2019
Query: 549 DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
D++LS +L R + L + Q ++S L+S + + + K S+L
Sbjct: 2020 DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES--LESLLQSIGEVEQNLEGKQVSSLS 2077
Query: 609 -GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA-----RMNEVISLWKK 662
G +Q+ A +L + +R + +A ++++ D A ++ EV +++
Sbjct: 2078 SGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137
Query: 663 LLEATELKGIKLREA-NQQQQFNRNVEDIELWLYEVEGHLASDDY-GKDLTNV-QNLQKK 719
L + K L++ Q + F ++ ++ LAS + +D+T+ Q +Q+
Sbjct: 2138 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQE- 2196
Query: 720 HALLEADVAAHQDRIDGITIQARQFQDAG-------HFD-AENIKKKQEALVARYEALKE 771
L ++ Q+ +D + + G H D +N++K L + ++
Sbjct: 2197 ---LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK 2253
Query: 772 PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831
+ +++L + +L + F + W++E E T ++ ++ ++L
Sbjct: 2254 DASSCQEQLDEFRKLVRTF------QKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLD 2307
Query: 832 EIAGHEPRIKAVTQKGNAMVE----------------------------EGHFAAED--- 860
+ A ++ + KG ++ G+ +D
Sbjct: 2308 DWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTE 2367
Query: 861 VKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESWMREKEPIVGSTDYG 919
++ + ++N K+E L +R++ L+ L + ++ +AN W+ KE ++ S D
Sbjct: 2368 IQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAM 2427
Query: 920 KDEDSAE---ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976
E A + ++A +++L IQ ++E L L
Sbjct: 2428 SSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA------------------LAGLLV 2469
Query: 977 DYQEKSPREVTMKKGDILTLLNSTNKDWWKVEV-NDRQGFVPAAYVKKLDPAQSASRENL 1035
Y E K I LNS + +V V RQ A+++ A+S R L
Sbjct: 2470 TYPNSQEAENWKK---IQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL 2526
Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
+E++ + + + + + V +K+ E +L E +G+L +
Sbjct: 2527 MEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSL 2586
Query: 1096 LFREANELQQWINEKEAALTSE--EVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKV 1153
+ + Q IN+K LT + + ++Q V ++ + +DL + + V
Sbjct: 2587 STSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLS------EKVRAV 2640
Query: 1154 AEDLESEGLMAEEVQAVQQQ-----EVYGMMPRDETDSKTASPW-KSARLMVHTVATFNS 1207
+ L + ++ + +AV+QQ E+ + + + + K A +++ +
Sbjct: 2641 GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 2700
Query: 1208 IKELNER----WRSLQQLAEER-SQLLGSAHEVQRFHRDADETKEWIEEK-NQALNTDNY 1261
+K+ E + L+ LA +R ++L + Q+F + DE + W+++K +Q
Sbjct: 2701 LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI 2760
Query: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP--ESAEDLQEKCTELNQ 1319
L +Q+ +++E F++ L + E L+ S P E LQ + EL
Sbjct: 2761 SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN 2820
Query: 1320 AWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
W L K+ R+++L D Q++ DL+ WI + +S + D E+ L
Sbjct: 2821 HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL 2880
Query: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438
R + E++ R + L+ D++ EKA + +
Sbjct: 2881 LRSKAMLNEVEKRRSLLEILNSAADILINSSE------------ADEDGIRDEKAGINQN 2928
Query: 1439 M-MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDS-------LDSVEALIKKHEDF 1490
M + + L+ + + E + +E+F N E K + D++ + +++
Sbjct: 2929 MDAVTEELQAKTGSLE-EMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL 2987
Query: 1491 DKAINVQEEKIAALQAFADQL--IAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG 1548
+K + Q+E + AL+ D L G S +++L + + + +E + ++
Sbjct: 2988 EK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVN 3046
Query: 1549 ES-------------------QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSK 1589
+ Q + DE++ + T S +S + + L+K
Sbjct: 3047 SGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNK 3106
Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLV 1649
+ +A EAE + G +D+ E A + R A +Q + +
Sbjct: 3107 IHVLKLDIEASEAECRHMLEE-EGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL 3165
Query: 1650 QKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLE 1709
+ + +KLK G+ D E EAL G ++ +N L ++ +
Sbjct: 3166 GRVEDFYRKLK----------GLNDATTAAEEAEAL--QWVVGTEVEIINQQLADFKMFQ 3213
Query: 1710 AD-ISAHEDRLKDLNSQADSLMTSSA--FDTSQVKDKRDTINGRFQKIKSMAASRRAKLN 1766
+ + + +L+ +N L+ S+ D ++ + IN R+ + A R A+L
Sbjct: 3214 KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQ 3273
Query: 1767 ESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPA 1824
E+ F+D ++ SW+ + ++L+ + + V+ ++ K L+ L +
Sbjct: 3274 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3333
Query: 1825 IQGVLDTGKKLSDDNTIG-KEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEY-QQFVA 1882
+ + G +++ + +E+I +L W EL AAAR ++LE+ L +QF
Sbjct: 3334 VDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHE 3393
Query: 1883 NVEEEEAWIN-EKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDL 1941
E +++ + L SE G A IQ + +H+A E D H V+ GQ L
Sbjct: 3394 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3453
Query: 1942 IKKNNHHEENI-SSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADV-VESWIGE 1999
+ E+ + S K+ L + S+++ ++ A LD+ + + + +V V +W+ E
Sbjct: 3454 SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAE 3513
Query: 2000 KENSLKT---DDYGRDL---SSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKH 2053
E+ L + D+ +D+ L +E + + I N AL Q +
Sbjct: 3514 VEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNV--DQAIKNGQALLKQTTGEEV 3571
Query: 2054 VQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE 2113
+ I+ + + R++ + S+ + L +A+ L F W
Sbjct: 3572 L---LIQEKLDGIKTRYADITVTSSKALRTLEQAR-------QLATKFQSTYEELTGWLR 3621
Query: 2114 NAEEDL-TDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPY 2172
EE+L T + + E+I ++ + + + + + E+ R +
Sbjct: 3622 EVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL------V 3675
Query: 2173 TWFTMEALE-------ETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW 2225
W E L+ E ++ + I +R E+ +R Q++ Q A+A W
Sbjct: 3676 PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS-------QQYEQAADAELAW 3728
Query: 2226 IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKI-----EDLGAAMEEA 2280
+ ET+ L+ + E +QL+ K +I + + ++ E G EE
Sbjct: 3729 VAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEE- 3787
Query: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQ 2315
+ T L QQ++ + L LE+
Sbjct: 3788 ---QKTVLQEKTESLIQQYEAISLLNSERYARLER 3819
Score = 168 bits (425), Expect = 7e-41
Identities = 331/1803 (18%), Positives = 726/1803 (40%), Gaps = 216/1803 (11%)
Query: 9 LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRF-QFFQRDAEELEKWIQ--EKLQ 65
L E I + + + R+ + R+++LED + F AE + ++ EK
Sbjct: 3350 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3409
Query: 66 IASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125
S+ +Q ++ +H+A E +++ ++ + + + G + S A + + + +
Sbjct: 3410 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3469
Query: 126 E-LHRQWELLLEKMREKGIKLLQAQKLVQYLRECE-DVMDW---INDKEAIVTSEELGQD 180
+ L ++ + ++ K L QA + E E +V++W + DK + V ++ QD
Sbjct: 3470 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 3529
Query: 181 LEHVEVLQKKFEEFQTDMAAHEERVNE-------VNQFAAKLIQEQHPEEELIKTKQDEV 233
+ H + +A +EE VN + A L Q E LI+ K D +
Sbjct: 3530 VLH--------RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 3581
Query: 234 NAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETISWIKE-KEQLMASDDFGRDLASVQ 291
+ + + + L A ++ +F +E W++E +E+L S +
Sbjct: 3582 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIP 3641
Query: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
++ + L++++ + + + L + P A + ++L+++ + L +
Sbjct: 3642 QFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVS 3698
Query: 352 ERHARLNDSY-----RLQRFLADFRDLTSWVTEMKALINA--------DELASDVAGAEA 398
+ + D R Q++ +WV E K + A D+ + + +A
Sbjct: 3699 DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKA 3758
Query: 399 L---LDRHQEHKGEIDAHEDS-FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
+ RH++ E+ +H F + E + +L + + E +++L+ ER A LE
Sbjct: 3759 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 3818
Query: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514
++ Q F+ E++ W+ + A + L E L ++ E+ +
Sbjct: 3819 RAQVLVNQ---------FWETYEELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQ 3867
Query: 515 ---SLSAQEEKITALDEFATKLIQNNHYAMEDVATR----RDALLSRRNALHERAMRRRA 567
S++ + I L + +L + N E V + + + + +RA+
Sbjct: 3868 LRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDE 3927
Query: 568 QLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP------SNLQGKVQKHQAFEAEL 621
++ S + +F D+++ + E ++ + P ++ + +++ EL
Sbjct: 3928 AVSQSTQITEFH---DKIEPML-ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVEL 3983
Query: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAAR-----MNEVISLWKKLLEATELKGIKLRE 676
Q +AL++ G++LI + A ++AA+ +++++ W+ IK R
Sbjct: 3984 EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED---------IKARA 4034
Query: 677 ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN------------VQNLQKKHALLE 724
++ +F +E E + Y++ L + +D+ + Q ++ + E
Sbjct: 4035 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094
Query: 725 ADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
H++ + A G + ++K + + +E L + R +KL D++
Sbjct: 4095 ETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAM 4154
Query: 785 RLQQLFRD-VEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
+ ++D ++ W+ + G DL V++ L + + + E+ + ++
Sbjct: 4155 QAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEK 4214
Query: 843 VTQKGNAMVEEGHFAAED--VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA- 899
+ +G M+++ + ++ L EL WE L K + R+ LE +L A F A
Sbjct: 4215 LNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHAL 4274
Query: 900 NEAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQ 958
E SW+ E ++ + D E L KH L +D+ A+ ++++ + + +
Sbjct: 4275 EELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLE 4334
Query: 959 QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE---------- 1008
A D + + + A+ E ++ ++ + + L ++E
Sbjct: 4335 SSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRME 4394
Query: 1009 ----VNDRQGFVPAAYVKKLDP-----AQSASRE---NLLEEQGSIALRQEQIDNQTRIT 1056
+ G +P ++LD +Q ++E N L ++G + L D+ +
Sbjct: 4395 SQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR--DDSGSGS 4452
Query: 1057 KEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
K SV+L +E+ +H + E+RK LE++ F+ N LQ++IN A S
Sbjct: 4453 KTEQSVAL----LEQKWHVVSSKMEERKSKLEEALNLATEFQ--NSLQEFINWLTLAEQS 4506
Query: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
+ + + +N V +E + A EV A + Q +
Sbjct: 4507 LNIASPPSLI-----------------------LNTVLSQIEEHKVFANEVNAHRDQII- 4542
Query: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHE-V 1235
E D +T + K V N + + RW + Q + ER + L A +
Sbjct: 4543 ------ELD-QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 4595
Query: 1236 QRFHRDADETKEWIEEKNQALNTD-NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGE 1294
++FH + +W+E+ L+++ +D ++ KH+ F++ L ++
Sbjct: 4596 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655
Query: 1295 TAERLIQSH--PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
T L + PE ++ L E+ W ++ ++ +R+ KL ++ +F+ + L
Sbjct: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
Query: 1352 MSWINGIRGLVSSDE-LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
+ W+ + ++ D+ + D+ L++ H+ + E+ R GT Q ++ G++L+ +
Sbjct: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775
Query: 1411 YASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAFLN 1469
+ +K +L L + K V ++ L+Q L + ++F W++ E L
Sbjct: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 4835
Query: 1470 TEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGH--------YAKG 1520
D +++++LI H++F K + + + + A + ++A H +
Sbjct: 4836 FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWIT 4895
Query: 1521 DISSRRNEVLDRWRRLKAQMIEKR-SKLGESQTLQQFSRDVDEIEAWISEKLQTASDESY 1579
I +R EVL W + Q +E S+L + L ++E+ AWI + +T +
Sbjct: 4896 IIRARFEEVLT-WAKQHQQRLETALSELVANAEL------LEELLAWI-QWAETTLIQRD 4947
Query: 1580 KDPTNIQLSKLLSKHQKHQAFEAEL---HANADRIRGVIDMGN------SLIERGACAGS 1630
++P + ++ + +HQ F E+ + DR+ N IE+ G
Sbjct: 4948 QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR 5007
Query: 1631 E----------------DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKD 1674
+ +A R+ L+ +WQ + + E+ +KL +A + +
Sbjct: 5008 KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFAN 5067
Query: 1675 FDF 1677
FDF
Sbjct: 5068 FDF 5070
Score = 125 bits (315), Expect = 4e-28
Identities = 475/2576 (18%), Positives = 978/2576 (37%), Gaps = 404/2576 (15%)
Query: 31 ELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE---KLQIASDENYKDPTNLQGKLQKHQA 87
EL + + E + RF + EL W++E KL+ A N LQ + Q+H
Sbjct: 573 ELVAISSSEDEGNLRFVY------ELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIH 626
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMRE-KGIKLL 146
E +S +L E G + S+ T E + E K++E ++
Sbjct: 627 TSVEELGSSVKEARLYE-GKM--------SQNFHTSYAETLGKLETQYCKLKETSSFRMR 677
Query: 147 QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
Q L +++ + W+N+KE + + + ++ + F E ++ ++
Sbjct: 678 HLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFR 737
Query: 207 EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDE 266
+ A L E HP ++ ++ V + Q +K L L + + +F D E
Sbjct: 738 SLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARE 797
Query: 267 TISWIKEKEQLMA---SDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
S+++ + + S D L+ ++ LL+ + L + V +L + + Q
Sbjct: 798 LESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQ 857
Query: 324 SHPLSA----------------TQIQV---KREELI-------TNWEQIRTL-------- 349
P S QI++ K +E + T W+ I
Sbjct: 858 LKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPS 917
Query: 350 -----------AAERHARLNDSYRLQRFL-----ADFRDLTSWVTEMKAL-----INADE 388
A E +R+ SY+ L + + L SW K L N ++
Sbjct: 918 VCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEK 977
Query: 389 LASDVAG-AEALLDRHQEHKGE-IDAHEDS--FKSAD-----ESGQALLAAGHY--ASDE 437
L S G ++ Q H + + DS F AD E +A A + S E
Sbjct: 978 LRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSME 1037
Query: 438 VREKLTVLSEERAALLELWELRRQQYEQCMDLQL-------FYRDTEQVDNWMSKQEAFL 490
+K +++ + L+ LR ++YEQ + ++ RD Q DN + E
Sbjct: 1038 NEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQ-DNALRIAEQEH 1096
Query: 491 LNEDLGDSLDSVEALLKKHEDF------EKSLSAQEEKITALDE-----FATKLIQNNHY 539
EDL ++A+ K + F S+ ++ L E + + N
Sbjct: 1097 TQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKL 1156
Query: 540 AMEDVATR--RDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTAT 597
DV R +DA L + + + LAD L+ + L+ W+++ +
Sbjct: 1157 KTVDVIVRSIQDAELLVK-GYEIKLSQEEVVLADLSALEAHW---STLRHWLSDVKDKNS 1212
Query: 598 DEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVI 657
+ D + KV Q N ++ ++ G +L + H ++ R +E+
Sbjct: 1213 VFSVLDEEIAKAKVVAEQMSRLTPERNLD-LERYQEKGSQLQERWHRVIAQLEIRQSELE 1271
Query: 658 SLWKKL-----LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLA-SDDYGKDLT 711
S+ + L T +K I+ A Q+ ED + ++ A + ++ T
Sbjct: 1272 SIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQT 1331
Query: 712 NVQNLQKKHALLEADVAAHQDRIDGITIQA---RQFQDAGH-----FDAENIKKKQEALV 763
+ QK V ++ ++ +T +A Q + G ++ I ++ L
Sbjct: 1332 KLDQCQKFSQQYSTIVKDYELQL--MTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLR 1389
Query: 764 ARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEET-----------WI---REKEPIAA 808
RY AL + ++D+L RL++ + VE+E+ W+ A
Sbjct: 1390 TRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKA 1449
Query: 809 STNRGKDLIGVQNLLKKHQALQAEIAGHEPRI-KAVTQKGNAMVEEGHFAAEDVKAKLHE 867
+++ K+ ++ + + Q L E+ + ++ +A+ + + GH +E K ++ E
Sbjct: 1450 TSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISE 1509
Query: 868 ----LNQKWEALKAKASQRRQDLED---------SLQAQQ--YFADANEAESWMREKEPI 912
LN+ + L ++ + Q L+ +LQ QQ + SW+ + E
Sbjct: 1510 QLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERA 1569
Query: 913 VG-------------------------------STDYGKDEDSAEALLKKHEALMS--DL 939
+ +T + E +++++ +S +L
Sbjct: 1570 LAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL 1629
Query: 940 SAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKS--PREVTMKKGDILTLL 997
+A + +EQ ++ +++ E + + AL EKS +E+ K I LL
Sbjct: 1630 TALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALL 1689
Query: 998 NSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASREN--LLEEQGSIALRQ--EQIDNQT 1053
+ W V G + + ++ AS E L G + + Q E++D Q
Sbjct: 1690 D------WVTSVGSSGGQL-LTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQC 1742
Query: 1054 RITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
+ K L +Q L + + G ++ ML ++ EL++ + +
Sbjct: 1743 EMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKE---QYSTS 1799
Query: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
L E A+L+QV+ LQ + F +D K ES L+ K E++ G E + ++ ++
Sbjct: 1800 LAQSE--AELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKR 1857
Query: 1174 EVYGMMPRDETDSKTASPWK--SARLMVHTVATF--------------NSIKELNERWRS 1217
+ G D K + S + ++ +F + +K+ ER+ +
Sbjct: 1858 Q--GSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTA 1915
Query: 1218 LQ----QLAEERSQLLGSAHEVQRFHRDADETKEWI---EEKNQALNTDNYGHDLASVQA 1270
L +L + LLG H+ F AD + W+ E + L +D D +Q
Sbjct: 1916 LHSKCTRLGSHLNMLLGQYHQ---FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQE 1972
Query: 1271 LQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAED---LQEKCTELNQAWS----S 1323
+ + +LA V L + A +++ E A D +QE + + S
Sbjct: 1973 QLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYS 2032
Query: 1324 LGKRADQRKAKLGDSHDLQRFLSDF-------------RDLMSWINGI--RGLVSSDELA 1368
L +R+ + + S +Q L + + S +G+ L ++ +L
Sbjct: 2033 LAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLK 2092
Query: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDIL----D 1424
+D+ ++ LE +E T A + A + G A E+ Q+ + L
Sbjct: 2093 QDIARQKSSLEATREMVTRFMETADSTTA-------AVLQGKLA--EVSQRFEQLCLQQQ 2143
Query: 1425 QERADLEKAWVQRRMMLDQCLELQLF------------HRDCEQAENWMAAREAFLNTED 1472
++ + L+K Q M +LQ F D + + +E L ED
Sbjct: 2144 EKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMED 2203
Query: 1473 KGDSLDSVEALIKKHEDFDKAINV--QEEKIAALQAFADQLIAAGHYAKGDISSRRNEVL 1530
+ ++LD++E L+ + A+++ ++++ L+ +L + D SS + E L
Sbjct: 2204 QQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQ-EQL 2262
Query: 1531 DRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKL 1590
D +R+L + + S + S E+E I E L++ D+ T ++
Sbjct: 2263 DEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQI-EHLKSLLDDWASKGTLVEEINC 2321
Query: 1591 LSKHQKHQAFEAELHANADRIRGVI-DMGNSLIERGACAGSED--AVKARLAALADQWQF 1647
++ E + + ++ +G+S+ +D ++ ++ + +++
Sbjct: 2322 KGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEK 2381
Query: 1648 LVQKSAEKSQKLKE-ANKQQNFNTGIKDFDFWLSEVEALLASEDYGKD---LASVNNLLK 1703
L E+ + L+ N+ + + WL E +L S D +V +
Sbjct: 2382 LGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAE 2441
Query: 1704 KHQLLEADISAHEDRLKDLNSQADSLMTS--SAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
++ A++ + +++ + L+ + ++ + K ++ +N R+++ + +R
Sbjct: 2442 SNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVAR 2501
Query: 1762 RAKLNESHRLHQFFRDMDDE-ESWIKEKKLLVG-----SEDYGRDLTGVQNLRKKHKRLE 1815
+ +L ES F+ + + W+ EK+L++G S D Q ++ K E
Sbjct: 2502 QRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFE 2561
Query: 1816 AELAAHE---PAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLE 1872
A HE A QG+L TG D ++ ++Q+ L + W EL +R +++
Sbjct: 2562 ARRQQHEQLNEAAQGIL-TG---PGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQID 2617
Query: 1873 E----SLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHK 1928
+ S +YQ+ + ++ E+ + +++++ ++ A++ L++ +D
Sbjct: 2618 QAIVKSTQYQELLQDLSEKVRAVGQRLSVQSA--ISTQPEAVKQQLEETSEIRSDLEQLD 2675
Query: 1929 DRVNDVCTNGQDL--IKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFL-Q 1985
V + T +L + + ++ + +++ + + LE AA R +L A Q
Sbjct: 2676 HEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 2735
Query: 1986 FNWKADVVESWIGEKEN-SLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITAL 2044
F D + +W+ +K++ K L +Q+ L + E F L Q G +
Sbjct: 2736 FQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN--QHSGSYEVIVA 2793
Query: 2045 KDQ---LLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE----AQSHFRKVEDL 2097
+ + L + + ++ + L W +L +A R+ +L + AQ + VEDL
Sbjct: 2794 EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDL 2853
Query: 2098 FLTFAKKASAFNSWFENAEEDLT------DPVRCNS--------LEEIKALREAHDAFRS 2143
W E+ + ++ DPV+ S L E++ R + S
Sbjct: 2854 V-----------PWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNS 2902
Query: 2144 S----LSSAQADFNQLAE--------LDRQIKSFRVASNPYTWFT--MEALEETWRNLQK 2189
+ ++S++AD + + + +D + + + T + +E+++N++K
Sbjct: 2903 AADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEK 2962
Query: 2190 IIKERELELQ---------------KEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLL 2234
++ + +L+ ++ R Q+E + + + F Q + E
Sbjct: 2963 KVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGS 3022
Query: 2235 DGSCMVEESGT------------------LESQLEATKRKHQEIRAMRSQLKKIED 2272
D S ++ ++ +E++LE + H +R M SQL ++D
Sbjct: 3023 DASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3078
Score = 124 bits (310), Expect = 2e-27
Identities = 448/2519 (17%), Positives = 910/2519 (36%), Gaps = 406/2519 (16%)
Query: 51 RDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQ------AFEAEVQANSGAIVKLDE 104
++ E L + +Q LQI DENY L ++ + Q E G L+
Sbjct: 478 QECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLEL 537
Query: 105 TGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDW 164
++ H +E + W + M + + + + LR +++ W
Sbjct: 538 VPPSTLTTTHLKAEPLTKATHSSSTSW--FRKPMTRAELVAISSSEDEGNLRFVYELLSW 595
Query: 165 INDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE 224
+ + + + E G DL VE+ + + T + V E + K+ Q H
Sbjct: 596 VEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTS-- 653
Query: 225 LIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFG 284
++ + +LK + R L + +F + W+ EKE+ + D+
Sbjct: 654 -YAETLGKLETQYCKLKETSSFRMRHL---QSLHKFVSRATAELIWLNEKEEEELAYDWS 709
Query: 285 RDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQ-QSHPLSAT-QIQVKREELITN 342
+ +++ A L +L +D ++L A+ L ++HP T + +
Sbjct: 710 DNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQ 769
Query: 343 WEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDR 402
W + L E+H + N +Y +F +D R+L S++ ++ I L D
Sbjct: 770 WMKQLCLCVEQHVKENTAY--FQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDL 827
Query: 403 HQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERA---------ALL 453
Q+ S DE Q + + AS R K V + R+ ++
Sbjct: 828 LQD-------------SMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVK 874
Query: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNW----------MSKQEAFLLNEDLGDSLDSVE 503
+ + R+ + C + + D Q W M FL+ + D++E
Sbjct: 875 AVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPP---PNKDAIE 931
Query: 504 ALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAM 563
+ + ++K ++ + TK + + +Y +D+ + L + L A
Sbjct: 932 MASRVEQSYQKVMALWHQL-----HVNTKSLISWNYLRKDLDLVQTWNLEK---LRSSAP 983
Query: 564 RRRAQLADSF--HLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAE 620
Q+ + H + F +DS D + V ++++ E E
Sbjct: 984 GECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLR----------------------LEEE 1021
Query: 621 LSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ 680
+ A ++R L K+ + + K+E A+M +ELK I+LR +
Sbjct: 1022 VEACKARFQHLMKS------MENEDKEETVAKM-----------YISELKNIRLRLEEYE 1064
Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNL---QKKHALLEADVAAHQDRIDGI 737
Q+ + ++ LAS +D L +++H + D+ + +D +
Sbjct: 1065 QRVVKRIQS-----------LASSRTDRDAWQDNALRIAEQEHT--QEDLQQLRSDLDAV 1111
Query: 738 TIQARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED 795
+++ F Q ++ + LV + + + KL + + R ++D
Sbjct: 1112 SMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLK---TVDVIVRSIQD 1168
Query: 796 EETWIR-------EKEPIAASTNRGKD--------LIGVQNLLKKHQALQAEIAGHEPRI 840
E ++ ++E + A + + L V++ L EIA +
Sbjct: 1169 AELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIA----KA 1224
Query: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQA-QQYFADA 899
K V ++ + + E + E + K +L ++W + A+ R+ +LE + Y A
Sbjct: 1225 KVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACH 1284
Query: 900 NEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
W+ E G+ EDS +L + + + L A Q +Q Q QQ
Sbjct: 1285 GTLIKWIEETTAQQEMMKPGQAEDS--RVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQ 1342
Query: 960 VAPTDDETGKELVL--ALYDYQEKSP--REVTMKKGDILT------------LLNSTNK- 1002
+ + +L+ A + Q+KSP R + D +T L+ T +
Sbjct: 1343 YSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQH 1402
Query: 1003 ---------------------------------DWWKVEVNDRQGFVPAAYVKKLDPAQS 1029
W + QG ++ K+ +
Sbjct: 1403 VKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEK 1462
Query: 1030 ASRENLL--------EEQGSIALRQEQI----DNQTRITKEAGSVSLRMKQVEELYHSLL 1077
A E + +EQ S A++ QI KE +S ++ + + YH L
Sbjct: 1463 AILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLC 1522
Query: 1078 ELG----EKRKGMLEKSCKKFMLFREAN-------ELQQWINEKEAALTSEEVGADLEQV 1126
+ ++ + L ++ L ++ N +L W+ + E AL + + +
Sbjct: 1523 DGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL 1582
Query: 1127 EVLQKKFDDFQKDLKANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETD 1185
LQK N+S LKD+ + + S + ++++ ++ + PR+ T
Sbjct: 1583 SALQK-----------NQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA 1631
Query: 1186 SKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADET 1245
+ + T + KEL E S Q E+S+ +A E+ + D
Sbjct: 1632 LREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSK---AAKELAENKKKIDAL 1688
Query: 1246 KEWIE------------------------EKNQALNTDNYGHDLASVQALQRKHEGFE-R 1280
+W+ EK TD Y + + L ++ E + R
Sbjct: 1689 LDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR 1748
Query: 1281 DLAALGDKVNSL--GETAERLIQSH-----PESAEDLQEKCTELNQAWS-SLGKRADQRK 1332
L + N + ++A+ + H PE + LQ+K EL + +S SL + + K
Sbjct: 1749 HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELK 1808
Query: 1333 AKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE---ALLERHQEHRTEID 1389
+LQ+FL D ++ SW+ R + + K + E +LL+R ++
Sbjct: 1809 QVQTLQDELQKFLQDHKEFESWLE--RSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI 1866
Query: 1390 ARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLEL-- 1447
+ G + GQ++L + + E K+ +I + + L+ A + + +C L
Sbjct: 1867 SHKGDLRFVTISGQKVLDMEN-SFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGS 1925
Query: 1448 ---------QLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKH----EDFDKA 1493
F + + WM A EA N E D++ S ++++ + +
Sbjct: 1926 HLNMLLGQYHQFQNSADSLQAWMQACEA--NVEKLLSDTVASDPGVLQEQLATTKQLQEE 1983
Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGD---ISSRRNEVLDRWRRLKAQMIEKRSKL--- 1547
+ + + LQ A ++ D + + +L ++ L + E+ S L
Sbjct: 1984 LAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKA 2043
Query: 1548 -GESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHA 1606
+SQ++Q+ ++ + I E Q + ++ + + L+ + K + A +
Sbjct: 2044 IAQSQSVQE---SLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKS 2100
Query: 1607 NADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQ 1666
+ + R ++ + A ++ +LA ++ +++ L + EK LK+ Q
Sbjct: 2101 SLEATREMVTRFMETADSTTAA----VLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQA 2156
Query: 1667 NF--NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNS 1724
+ K F ++ L + +D+ +++ L D + D L+ L +
Sbjct: 2157 EMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVT 2216
Query: 1725 QADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE-SHRLHQFFRDMDDEES 1783
+ S A D Q +D+ + F +++ R + +L +F + + +
Sbjct: 2217 ELSS--CGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQK 2274
Query: 1784 WIKE------------------------KKLLVGSEDYGRDLTGVQNLRKKHKRLE---A 1816
W+KE K LL +D+ T V+ + K LE
Sbjct: 2275 WLKETEGSIPPTETSMSAKELEKQIEHLKSLL---DDWASKGTLVEEINCKGTSLENLIM 2331
Query: 1817 ELAAHEPAIQGVLDTGKKL-SDDNTIGK----------EEIQQRLAQFVEHWKELKQLAA 1865
E+ A P QG TG L S +++G EIQ ++ +++L +
Sbjct: 2332 EITA--PDSQG--KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLH 2387
Query: 1866 ARGQRLEESLEYQQFV-ANVEEEEAWINEKMTLVASEDYGDT---LAAIQGLLKKHEAFE 1921
R + L+ L + V W+ K ++ S D + ++ + ++AF
Sbjct: 2388 ERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFL 2447
Query: 1922 TDFTVHKDRVNDV--CTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE 1979
+ + ++ V G + N+ EN + LN + + R+ +L+E
Sbjct: 2448 AELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEE 2507
Query: 1980 NSAFLQ-FNWKADVVESWIGEKE--------NSLKTDDYGRDLSSVQTLLTKQETFDAGL 2030
+++ L F + W+ EKE S+ + VQ +L + E
Sbjct: 2508 SASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQH 2567
Query: 2031 QAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSH 2090
+ + +T D L+ VQ + S+ ++W +L +R ++ +A
Sbjct: 2568 EQLNEAAQGILTGPGDVSLSTSQVQKEL-----QSINQKWVELTDKLNSRSSQIDQAIVK 2622
Query: 2091 FRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRC--NSLEEIKALREAHDAFRSSLSSA 2148
+ ++L +DL++ VR L A+ +A + L
Sbjct: 2623 STQYQELL------------------QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEET 2664
Query: 2149 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEEN 2208
+ L +LD ++K + + + E + L+K ++ L LQ + +
Sbjct: 2665 SEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKD--ELKKRLETVALPLQGLEDLAADR 2722
Query: 2209 DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLK 2268
Q F Q E RT+L D ++ + ++LE + + QE + L
Sbjct: 2723 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 2782
Query: 2269 KIE---DLGAAMEEALIL------DNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQ 2318
+ ++ A E+L+L + + ++ V L W++L + Q L+ +Q
Sbjct: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQ 2841
Score = 99.0 bits (245), Expect = 5e-20
Identities = 361/1966 (18%), Positives = 716/1966 (36%), Gaps = 243/1966 (12%)
Query: 513 EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADS 572
EKSL E++ L + A K IQN E+ T L A E + +
Sbjct: 416 EKSLRPAVERLELLLQIANK-IQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVI 474
Query: 573 FHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQ------AFEAELSANQS 626
++Q+ + L + ++ DE Y L +V + Q E +
Sbjct: 475 MYIQE----CEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKG 530
Query: 627 RIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW-KKLLEATELKGIKLREANQQQQFNR 685
+LE + H + + + + W +K + EL I E +F
Sbjct: 531 HFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRF-- 588
Query: 686 NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745
V ++ W+ E++ L ++G DL +V+ + + V + + +
Sbjct: 589 -VYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMS 647
Query: 746 DAGHFD-AENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKE 804
H AE + K L +Y LKE R + L L + E W+ EKE
Sbjct: 648 QNFHTSYAETLGK----LETQYCKLKETSSFRMRHLQS---LHKFVSRATAELIWLNEKE 700
Query: 805 PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAK 864
+ + + + L E+ + +++ + E H A + V+A
Sbjct: 701 EEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAY 760
Query: 865 LHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVG---STDYGKD 921
+ + + +K Q ++++ Q+F+DA E ES++R + + S D+
Sbjct: 761 SAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTS 820
Query: 922 EDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKEL--VLALYDYQ 979
E LL+ L SS+ +L ++++ Q + D K V A+ DY+
Sbjct: 821 LSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYR 880
Query: 980 EKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV----KKLDPAQSASREN 1034
+ E+T+ K D L +++ + WKV + VP+ D + ASR
Sbjct: 881 Q---IEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVE 937
Query: 1035 LLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKF 1094
++ Q ++ ++ I+ L + Q L EK + C +
Sbjct: 938 QSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNL--------EKLRSSAPGECHQI 989
Query: 1095 MLFREANELQQWINEKEAALTS--------EEVGADLEQVEVLQKKFDDFQKD---LKAN 1143
M +A+ + +++ L S EEV A + + L K ++ K+ K
Sbjct: 990 MKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMY 1049
Query: 1144 ESRLKDINKVAEDLES----------------EGLMAEEVQAVQQQEVYGMMPRDETDSK 1187
S LK+I E+ E + ++ +Q+ + + +D
Sbjct: 1050 ISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLD 1109
Query: 1188 TASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKE 1247
S +H + +S+ L L L E+ + G + + D
Sbjct: 1110 AVS--MKCDSFLHQSPSSSSVPTLRS---ELNLLVEKMDHVYGLSTVYLNKLKTVDVIVR 1164
Query: 1248 WIEE-----KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK----------VNSL 1292
I++ K + LA + AL+ L+ + DK +
Sbjct: 1165 SIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKA 1224
Query: 1293 GETAERLIQSHPESAEDL---QEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFR 1349
AE++ + PE DL QEK ++L + W + + + R+++L +Q L D+R
Sbjct: 1225 KVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSEL---ESIQEVLGDYR 1281
Query: 1350 ----DLMSWINGIRG---------LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQ 1396
L+ WI S L++ ++ AL + ++T++D Q
Sbjct: 1282 ACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQ 1341
Query: 1397 AF----EQFGQQLLAHGHYA-----SPEIKQKL----DILDQERADLEKAWVQRRMMLDQ 1443
+ + + QL+ + + SP ++++ D + QE DL + + Q
Sbjct: 1342 QYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQ 1401
Query: 1444 CLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAA 1503
++ + E + E + E + L V L + + + +E
Sbjct: 1402 HVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIE 1461
Query: 1504 LQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEI 1563
Q+++ ++++++ +V + + + + + KL E + Q
Sbjct: 1462 KAILEQQVLSE------ELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQ--------- 1506
Query: 1564 EAWISEKLQTASDESYKDPTNIQLSKL--LSKHQKHQAFEAELHANADRIRGVIDMGNSL 1621
ISE+L A +++Y D + ++L L HQ + L + ++ S
Sbjct: 1507 ---ISEQL-NALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSW 1562
Query: 1622 IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKE--ANKQQNFNTGIKDFDFWL 1679
+ + +E A+ Q +QK+ + L++ N+ +F T +KD + ++
Sbjct: 1563 VGQ-----AERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFM 1617
Query: 1680 SEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQ 1739
E + L+ + ++ ++++ L+ + + L++ + A T + +
Sbjct: 1618 EENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKE 1677
Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGR 1799
+ + + I+ + S+ +S L + Q + L G+ D
Sbjct: 1678 LAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ-----------LSGASLEKGALDTTD 1726
Query: 1800 DLTGV-QNLRKKHKRLEAELAAHEPAI-------------QGVLDT-GKKLSDDNTIGKE 1844
GV Q K K+ E A H+ + Q LD G L+ + ++
Sbjct: 1727 GYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE---QQ 1783
Query: 1845 EIQQRLAQFVEHWK-ELKQLAAARGQRLEESLEYQQFVANVEEEEAWI-NEKMTLVASED 1902
+QQ+L + E + L Q A Q E Q+F+ + +E E+W+ + L
Sbjct: 1784 MLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHK 1843
Query: 1903 YGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGK 1962
G + + LLK+ +F D HK + V +GQ ++ N +E + +
Sbjct: 1844 GGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE--GKEPSEIGNL 1901
Query: 1963 VSDLEKAAAQRKAKLDENSAFL------------QFNWKADVVESWIGEKENSLKTDDYG 2010
V D K A +R L L QF AD +++W+ E
Sbjct: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE--------- 1952
Query: 2011 RDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRW 2070
++V+ LL+ D G+ QE +A L+++ LA V + ++ +M+
Sbjct: 1953 ---ANVEKLLSDTVASDPGV---LQEQLATTKQLQEE-LAEHQVPVEKLQKVARDIMEIE 2005
Query: 2071 SQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFN---SWFENAEEDLTDPVRCNS 2127
+ + ++ SHF + L + A+++S + ++ +E L ++ S
Sbjct: 2006 GEPAPDHRHVQETTDSILSHF---QSLSYSLAERSSLLQKAIAQSQSVQESLESLLQ--S 2060
Query: 2128 LEEIKALREAHDAFRSSLSSA------QADFNQLAELDRQIKSFRVASNPYTWFTMEALE 2181
+ E++ E SSLSS + ++ RQ S T F A
Sbjct: 2061 IGEVEQNLEGKQV--SSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2118
Query: 2182 ETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVE 2241
T LQ + E ++ +Q+E + ++ A F + + ++ + S M
Sbjct: 2119 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRM-- 2176
Query: 2242 ESGTLESQLEATKRKHQEIRAMRSQLKKIE-DLGAAMEEALILDNKYTEHSTVG----LA 2296
L + + Q+I Q++++ ++ E L++ TE S+ G L
Sbjct: 2177 --------LASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLC 2228
Query: 2297 QQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDK 2342
Q D++ L + + +E L EF + + F K
Sbjct: 2229 QHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQK 2274
Score = 70.9 bits (172), Expect = 2e-11
Identities = 91/435 (20%), Positives = 178/435 (40%), Gaps = 37/435 (8%)
Query: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIA 67
E ++ + +V D++ S R+ KLE++ F DA + L W+ + + Q+A
Sbjct: 4668 EDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLA 4727
Query: 68 SDENYKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLME 126
D+ +L + H+ F+ E+ +G + L +G +I + ++ +L E
Sbjct: 4728 EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 4787
Query: 127 LHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVM-DWINDKEAIVTSE-ELGQDLEHV 184
L +W+ + + K +L QA K + R+ ++ +W+++ E + L D E +
Sbjct: 4788 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEAL 4847
Query: 185 EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPE-EELIKTKQDEVNAAWQRLKGL 243
+ L +EF + VN ++ HP+ IK + A ++ +
Sbjct: 4848 QSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTW 4907
Query: 244 ALQRQGKLFGAAEVQRFNRDV-DETISWIKEKEQLMASDD---FGRDLASVQALLRKHEG 299
A Q Q +L A N ++ +E ++WI+ E + D +++ V+AL+ +H+
Sbjct: 4908 AKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQT 4967
Query: 300 LERDLAALEDKVKALCAEADR---------------------LQQSHP-----LSATQIQ 333
++ + V + R L Q P LS ++ +
Sbjct: 4968 FMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAK 5027
Query: 334 VKR-EELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASD 392
R +L W+Q+ LA ER +LND+ L +F + V K + + S
Sbjct: 5028 NPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSR 5087
Query: 393 VAGAEALLDRHQEHK 407
V +D+ Q+ K
Sbjct: 5088 VMDFFRRIDKDQDGK 5102
Score = 37.4 bits (85), Expect = 0.18
Identities = 119/605 (19%), Positives = 218/605 (36%), Gaps = 87/605 (14%)
Query: 180 DLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQR 239
D+E V++ + Q A ER+ A+ + P+E+ + T + A+ +
Sbjct: 242 DMERVQIQSNRENLEQAFEVA--ERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPK 299
Query: 240 LKGLALQRQGKLFGAAEV----QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLR 295
+ G+ A EV Q + VD I WIK+ LM+ F ++ ++AL
Sbjct: 300 VP-----EGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYN 354
Query: 296 KHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR---------EELITNWEQI 346
++ + E ++ A E R+++ + L I+ R ++ W ++
Sbjct: 355 QY------IHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKL 408
Query: 347 RTLAAERHARLNDSY-RLQRFLADFRDLTSWV--TEMKALINADELASDVAGAEA--LLD 401
ER L + RL+ L + + E K + + L +D A E+ +
Sbjct: 409 IIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQ 468
Query: 402 RHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAAL-LELWELRR 460
+ I E + Q L +Y +E+ ++ L +E L LE L R
Sbjct: 469 CESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYR 528
Query: 461 QQYEQCMDL--------------QLFYRDTEQVDNWMSKQ------EAFLLNEDLG---- 496
+ + ++L L +W K A +ED G
Sbjct: 529 KGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRF 588
Query: 497 --DSLDSVEALLKKHE---------DFEKSLSAQEEKITALDEFAT----------KLIQ 535
+ L VE + K E E L Q+ T+++E + K+ Q
Sbjct: 589 VYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQ 648
Query: 536 NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT 595
N H + + + + + L E + R L L +F + W+NEK +
Sbjct: 649 NFHTSYAETLGKLETQYCK---LKETSSFRMRHLQS---LHKFVSRATAELIWLNEKEEE 702
Query: 596 ATDEAYKD-PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
+ D SN+ K EL Q +L+ + L NH AK V A
Sbjct: 703 ELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSA 762
Query: 655 EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLA---SDDYGKDLT 711
V S + + + ++E QF + ++E +L ++ + S D+ L+
Sbjct: 763 AVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLS 822
Query: 712 NVQNL 716
+++L
Sbjct: 823 RLEDL 827
>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [Homo
sapiens]
Length = 678
Score = 203 bits (517), Expect = 1e-51
Identities = 171/638 (26%), Positives = 290/638 (45%), Gaps = 47/638 (7%)
Query: 593 MKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAAR 652
M A D +D L + +HQAF AEL+ N+ ++ +E+ GQ+L+ V +
Sbjct: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
Query: 653 MNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN 712
+ E+ W +L T+ K +L EA++ Q ++ +++ L +E L D G DL
Sbjct: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
Query: 713 VQNLQKKHALLEADVAAHQDRIDGITIQ--ARQFQDAGHFDAENIKKKQEALVARYEALK 770
V + KK +E+ V + + Q A + A E + ++Q A+ R L
Sbjct: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK---ELVGERQNAVGERLVRLL 177
Query: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830
EP+ R++ L S L Q+ D++DE W++E+ P+A T RG L VQ +KK+Q L+
Sbjct: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237
Query: 831 AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890
EI H PR++ V ++ A+ AE V+ L +L W L+ A +R+Q L+ +
Sbjct: 238 REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297
Query: 891 QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
Q +QY+ D E E+W+ E+E ++ S D GKDE S LLKKH L + Y SI L
Sbjct: 298 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357
Query: 951 EQAQSCRQQVAPTDDETGK------ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDW 1004
Q ++ + P ++ + L +AL + E+ R V +++ L L+
Sbjct: 358 RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLYQLSR----- 410
Query: 1005 WKVEVNDRQGFVPAAYVKKLDP--AQSASRENLLEEQGS-------------IALRQEQI 1049
+V++ + ++ V P Q ++L+E+ S +A + +
Sbjct: 411 ---QVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467
Query: 1050 DNQTRITKEAGSVSLRMKQ-VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWIN 1108
D A + K + E + LLEL R +L S + F +A ELQ I
Sbjct: 468 DELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527
Query: 1109 EKEAALTSEEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES--EGLMAE 1165
EK L + +Q+ F+ DL+ S+++ + + A L + G AE
Sbjct: 528 EKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAE 587
Query: 1166 EVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVA 1203
+ + +Q+ + G + S + ARL V + A
Sbjct: 588 AIASREQEVLQGW-------KELLSACEDARLHVSSTA 618
Score = 188 bits (478), Expect = 5e-47
Identities = 137/515 (26%), Positives = 238/515 (46%), Gaps = 6/515 (1%)
Query: 1580 KDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLI-ERGACAGSEDAVKARL 1638
+D T KL + +HQAF AEL N + + + G L+ E+ A S V+ +L
Sbjct: 5 RDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS---VRKKL 61
Query: 1639 AALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASV 1698
+ W L + K+++L EA+K + D L +E+ L D G DLA+V
Sbjct: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMA 1758
N+ LKK Q +E+ + + +L +Q +L A V ++++ + R ++
Sbjct: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA-SKELVGERQNAVGERLVRLLEPL 180
Query: 1759 ASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL 1818
RR L S LHQ D+DDE +W++E+ L + G L VQ KK++ L E+
Sbjct: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
Query: 1819 AAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQ 1878
AH P ++ VL+ L+ + E +++ L Q W L++ A R Q L+ + + +
Sbjct: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
Query: 1879 QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNG 1938
Q+ +V E EAW+ E+ L+ SED G + LLKKH E +++ + +
Sbjct: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
Query: 1939 QDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIG 1998
+ L++ + E IS + ++ L++ +R+ L++ Q + + +E WI
Sbjct: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
Query: 1999 EKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKA 2058
EKE + + G+D V L K F + +E +A + + D+L+ H +
Sbjct: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480
Query: 2059 IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRK 2093
+ L + W++LL R +LL A K
Sbjct: 481 MAEWKDGLNEAWAELLELMGTR-AQLLAASRELHK 514
Score = 157 bits (398), Expect = 9e-38
Identities = 135/560 (24%), Positives = 251/560 (44%), Gaps = 10/560 (1%)
Query: 37 RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANS 96
RQ E S Q Q AE +K + + Q+ + D + +L+K Q+ E++V+
Sbjct: 80 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 139
Query: 97 GAIVKLD-ETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYL 155
+ +L +T L + + E + R + + LLE ++E+ LL +++L Q
Sbjct: 140 REVGELQAQTAALPLEPA--SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVA 197
Query: 156 RECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKL 215
+ +D + W+ ++ + E G L+ V+ KK + + ++ AH R+ EV + A L
Sbjct: 198 HDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 257
Query: 216 IQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKE 275
+ PE E ++ +++ +AW L+ A +RQ L A +V+++ DV E +W+ E+E
Sbjct: 258 ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQE 317
Query: 276 QLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADR-LQQSHPLSATQIQV 334
LM S+D G+D S LL+KH LE+ + E+ + L + L+ HP + QI
Sbjct: 318 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP-DSEQISR 376
Query: 335 KREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVA 394
++ ++ + ++ L ER L Y L + +L W+ E + + + EL D
Sbjct: 377 RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFE 436
Query: 395 GAEALLDRHQEHKGEID-AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALL 453
L ++ E E A + + ++ L+ GH A+ + E L+E A LL
Sbjct: 437 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELL 496
Query: 454 ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN-EDLGDSLDSVEALLKKHEDF 512
EL R Q +L F+ D ++ + ++ L + S ++ + F
Sbjct: 497 ELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAF 556
Query: 513 EKSLSAQEEKITALDEFATKL--IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLA 570
E L ++ L E A +L + +A E +A+R +L L R ++
Sbjct: 557 EHDLQLLVSQVRQLQEGAAQLRTVYAGEHA-EAIASREQEVLQGWKELLSACEDARLHVS 615
Query: 571 DSFHLQQFFRDSDELKSWVN 590
+ +F +L SW++
Sbjct: 616 STADALRFHSQVRDLLSWMD 635
Score = 154 bits (389), Expect = 1e-36
Identities = 142/617 (23%), Positives = 255/617 (41%), Gaps = 20/617 (3%)
Query: 190 KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
+ + F ++A ++E + ++ + +L+QE+ ++ K E+ W L+ +
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
+LF A++ + + E + E + D G DLA+V + L+K + +E +
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 310 KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
+V L A+ L P S + ++ + ++ ER L S L + D
Sbjct: 141 EVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHD 199
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
D +WV E L E + + + + ++Q + EI AH + E AL +
Sbjct: 200 LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALAS 259
Query: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
++ VR L L A L E E R+Q + ++ +Y D +V+ W+ +QE
Sbjct: 260 LRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELL 319
Query: 490 LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549
+++ED G S LLKKH E+ + EE I L L++ H E ++ R+
Sbjct: 320 MMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 379
Query: 550 ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA-TDEAYKDPSNLQ 608
+ AL E RR L + L Q R EL+ W+ EK A + E +D ++
Sbjct: 380 QVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 439
Query: 609 GKVQKHQAFEAELS-ANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667
+K F +E A + R+ A+ + +LI+ H A +A + + W +LLE
Sbjct: 440 VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELM 499
Query: 668 ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
+ L + + +F + +++ + E L LT + + ++ +
Sbjct: 500 GTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR------LTTPPEPRPSASSMQRTL 553
Query: 728 AAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVARYEALKEPMVAR-- 776
A + + + Q RQ Q+ AG ++QE L E L AR
Sbjct: 554 RAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLH 613
Query: 777 KQKLADSLRLQQLFRDV 793
AD+LR RD+
Sbjct: 614 VSSTADALRFHSQVRDL 630
Score = 153 bits (386), Expect = 2e-36
Identities = 132/648 (20%), Positives = 286/648 (44%), Gaps = 11/648 (1%)
Query: 277 LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
LMA D D + +H+ +LA ++ ++ + E +L Q P A ++ K
Sbjct: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
Query: 337 EELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGA 396
E+ W ++ + + +L ++ + + + F +L + M++ + + D+A
Sbjct: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
Query: 397 EALLDRHQEHKGEIDAHEDSFKSADE--SGQALLAAGHYASDEVREKLTVLSEERAALLE 454
+ L + Q + ++ E+ ++ E + A L + + V E+ + E LLE
Sbjct: 122 NSQLKKLQSMESQV---EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178
Query: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514
+ RR+ +L D + W+ ++ + + G+ L +V+ +KK++ +
Sbjct: 179 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 238
Query: 515 SLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFH 574
+ A ++ + E A L E V + L S L E A RR+ L +F
Sbjct: 239 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 298
Query: 575 LQQFFRDSDELKSWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEK 633
++Q++ D E+++W+ E ++ +++ KD + ++KH E + + I L +
Sbjct: 299 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 358
Query: 634 AGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELW 693
+ L+++ H ++++ R ++V L+ L E E + + L + Q +R V ++E W
Sbjct: 359 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHW 418
Query: 694 LYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA-AHQDRIDGITIQARQFQDAGHFDA 752
+ E E S + G+D +V LQ+K + ++ A ++R+ + + + GH A
Sbjct: 419 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 478
Query: 753 ENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK-EPIAASTN 811
+ + ++ L + L E M R Q LA S L + F D + + I EK + T
Sbjct: 479 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTT 538
Query: 812 RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFA--AEDVKAKLHELN 869
+ ++ + +A + ++ +++ + Q+G A + + AE + ++ E+
Sbjct: 539 PPEPRPSASSMQRTLRAFEHDLQLLVSQVRQL-QEGAAQLRTVYAGEHAEAIASREQEVL 597
Query: 870 QKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTD 917
Q W+ L + R + + A ++ + + SWM +G+ D
Sbjct: 598 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
Score = 149 bits (377), Expect = 3e-35
Identities = 130/617 (21%), Positives = 271/617 (43%), Gaps = 20/617 (3%)
Query: 1081 EKRKGMLEKSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKD 1139
E ++ M EK + ++ E++Q W + + + + L + F + K
Sbjct: 42 EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKK 101
Query: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTAS-PWKSARLM 1198
L ES+L+D++ DL + +++Q+++ Q E ++TA+ P + A
Sbjct: 102 LLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKE 160
Query: 1199 VHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNT 1258
+ + ER L + +ER +LL ++ E+ + D D+ W++E+
Sbjct: 161 L----VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQ 216
Query: 1259 DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
G+ L +VQ +K++G R++ A G ++ + E A L AE ++ +L
Sbjct: 217 TERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQ 276
Query: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
AW+ L + A++R+ L + ++++ D ++ +W+ L+ S++ KD LL
Sbjct: 277 SAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLL 336
Query: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438
++H + ++ + + + LL GH S +I ++ +D+ L++ +RR
Sbjct: 337 KKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 396
Query: 1439 MMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ- 1497
+ L+Q L R + E+W+A +E + + G + V L +K +F +
Sbjct: 397 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 456
Query: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
E++AA+ D+LI GH A ++ ++ + + W L M + L S+ L +F
Sbjct: 457 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 516
Query: 1558 RDVDEIEAWISEK---LQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGV 1614
D E++ I EK L + P+ + + L +AFE +L ++R +
Sbjct: 517 SDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL------RAFEHDLQLLVSQVRQL 570
Query: 1615 IDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK 1673
+ L R AG +A+ +R + W+ L+ + + F++ ++
Sbjct: 571 QEGAAQL--RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVR 628
Query: 1674 DFDFWLSEVEALLASED 1690
D W+ + + + + D
Sbjct: 629 DLLSWMDGIASQIGAAD 645
Score = 144 bits (364), Expect = 8e-34
Identities = 107/382 (28%), Positives = 184/382 (48%), Gaps = 10/382 (2%)
Query: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDE 70
AE ++ +Q+ + +E + R+Q L+ +++ + + D E+E W+ +++L + S++
Sbjct: 265 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 324
Query: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
KD + L+KH E V+ +I +L ++ GH SE I R ++ R
Sbjct: 325 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 384
Query: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
+ L E E+ + L Q L Q R+ ++ WI +KE + S ELGQD EHV VLQ+K
Sbjct: 385 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 444
Query: 191 FEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
F EF ++ A ER+ VNQ +LI+ H + +D +N AW L L R
Sbjct: 445 FSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQ 504
Query: 250 KLFGAAEVQRFNRDVDETISWIKEKE----QLMASDDFGRDLASVQALLRKHEGLERDLA 305
L + E+ +F D E I+EK +L + +S+Q LR E DL
Sbjct: 505 LLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQ 561
Query: 306 ALEDKVKALCAEADRLQQSHP-LSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
L +V+ L A +L+ + A I + +E++ W+++ + + ++ +
Sbjct: 562 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 621
Query: 365 RFLADFRDLTSWVTEMKALINA 386
RF + RDL SW+ + + I A
Sbjct: 622 RFHSQVRDLLSWMDGIASQIGA 643
Score = 121 bits (304), Expect = 7e-27
Identities = 126/658 (19%), Positives = 276/658 (41%), Gaps = 40/658 (6%)
Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
+H+ F +LA + + + ++L+Q PE A +++K E+ Q W+ L +
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 1334 KLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEID---A 1390
+L ++ + + F +L + + + + D+ + L++ Q ++++
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 1391 RAGTFQAFEQFGQQLLAHGHYASPE-IKQKLDILDQERADLEKAWVQRRMMLDQCLELQL 1449
G QA Q AS E + ++ + + + L + +RR +L EL
Sbjct: 141 EVGELQA-----QTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQ 195
Query: 1450 FHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFAD 1509
D + W+ R ++G+ L +V+ IKK++ + I ++ + A
Sbjct: 196 VAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAG 255
Query: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE 1569
L + + ++ W L+ ++ L + ++Q+ DV E+EAW+ E
Sbjct: 256 ALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 315
Query: 1570 K--LQTASDESYKDPTNIQ-LSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626
+ L + D+ + + +Q L K L Q + +E + + + R +++MG+
Sbjct: 316 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP------ 369
Query: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686
+ + R + + + L + E+ L++ + + + + W++E E +
Sbjct: 370 ---DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 426
Query: 1687 ASEDYGKDLASVNNLLKKHQLLEADIS-AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRD 1745
S + G+D V+ L +K ++ A +RL +N D L+ + + + +D
Sbjct: 427 GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD 486
Query: 1746 TINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ 1805
+N + ++ + +R L S LH+FF D + + I+EK+ + LT
Sbjct: 487 GLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR------LTTPP 540
Query: 1806 NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDD----NTI----GKEEIQQRLAQFVEHW 1857
R ++ L A E +Q ++ ++L + T+ E I R + ++ W
Sbjct: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600
Query: 1858 KELKQLAAARGQRLEES--LEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGL 1913
KEL L+A RL S + +F + V + +W++ + + + D +++ GL
Sbjct: 601 KEL--LSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSLLGL 656
Score = 119 bits (299), Expect = 3e-26
Identities = 92/371 (24%), Positives = 168/371 (45%), Gaps = 2/371 (0%)
Query: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA-SDEN 71
E + ER+ V +R R E RR+ L S D ++ W+QE+L +A E
Sbjct: 160 ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER 219
Query: 72 YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
+Q ++K+Q E+QA+ + ++ E + S +E +R L +L W
Sbjct: 220 GNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW 279
Query: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
L E + L A ++ QY + +V W+ ++E ++ SE+ G+D + L KK
Sbjct: 280 AGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKH 339
Query: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
+ + + +EE + ++++ L++ HP+ E I +Q +V+ + LK L +R+ L
Sbjct: 340 LQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVAL 399
Query: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA-ALEDK 310
+ + +R V E WI EKE + S + G+D V L K + A ++
Sbjct: 400 EQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 459
Query: 311 VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370
+ A+ D L + +A + ++ L W ++ L R L S L +F +D
Sbjct: 460 LAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDA 519
Query: 371 RDLTSWVTEMK 381
R+L + E +
Sbjct: 520 RELQGQIEEKR 530
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 186 bits (473), Expect = 2e-46
Identities = 439/2327 (18%), Positives = 908/2327 (39%), Gaps = 344/2327 (14%)
Query: 19 RQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE---KLQIASDENYKDP 75
+Q D R KEL T+ D+ +Q + W+Q+ KL I + D
Sbjct: 911 KQVFSDVQAREKELQTIF-----DTLPPMRYQETMSAIRTWVQQSETKLSIPQ-LSVTDY 964
Query: 76 TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFA-SETIRTRLMELHRQWELL 134
++ +L + QA ++ +Q + L T M + S ++ E+ +W+ L
Sbjct: 965 EIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKL 1024
Query: 135 LEKMREKGIKLL-QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
++ E KL Q KL + + + W+ + + + E L E+L+K+ ++
Sbjct: 1025 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEE--WPALGDSEILKKQLKQ 1082
Query: 194 FQ---TDMAAHEERVNEVNQFAAKLIQEQHPE-EELIKTKQDEVNAAWQRLKGLALQRQG 249
+ +D+ + +N VN+ K+ E PE ++T+ E+N W + R+
Sbjct: 1083 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKE 1142
Query: 250 KLFGAAE-VQRFNRDVDETISWIKEKEQLMASDDFG-RDLASVQALLRKHEGLERDLAAL 307
L G E +D+ E W+ + E+ DF + +Q + + + + +
Sbjct: 1143 ALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQK 1202
Query: 308 EDKVKALCAEADR-LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR-LQR 365
E KVK L + + Q+ P++ ++ + E L TN++ + T RLN + L+
Sbjct: 1203 EAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCT-------RLNGKCKTLEE 1255
Query: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
A + +L S++ + +N E+ + E + +E +D+ E+ + ++++
Sbjct: 1256 VWACWHELLSYLEKANKWLN--EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1313
Query: 426 AL------LAAGHYASDEVREKLTV-------LSEE---RAALLELWELRRQQYEQCM-- 467
+ L G + + E+L L EE R LLE Q+ E+ +
Sbjct: 1314 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1373
Query: 468 --------DLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQ 519
D QL ++VD QEA + DL S+E + K ++ E A
Sbjct: 1374 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKE----AA 1429
Query: 520 EEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFF 579
+ ++ +D KL +DV+ + L ++ A E+ ++ + D +
Sbjct: 1430 QRVLSQIDVAQKKL--------QDVSMK--FRLFQKPANFEQRLQESKMILDEVKMHLPA 1479
Query: 580 RDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLI 639
++ ++ V + YK LS +S ++ + K G++++
Sbjct: 1480 LETKSVEQEVVQSQLNHCVNLYKS-----------------LSEVKSEVEMVIKTGRQIV 1522
Query: 640 DVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ--------QQFNRNVEDIE 691
+ E ++E ++ K L EL G K+ E QQ ++ + + +
Sbjct: 1523 QKK---QTENPKELDERVTALK--LHYNEL-GAKVTERKQQLEKCLKLSRKMRKEMNVLT 1576
Query: 692 LWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA---AHQDRIDGITIQARQFQDAG 748
WL + +LT ++ + L+++VA A Q I+ + + + G
Sbjct: 1577 EWLAATD---------MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1627
Query: 749 HFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL--------QQLFRDVEDEETWI 800
+ KK+ + + L +A + + L L + ++V+ WI
Sbjct: 1628 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 1687
Query: 801 REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT-QKGNAMVEEGHFAAE 859
+ + + + + K +++LK+ L+AE+ P++ + Q N M G +
Sbjct: 1688 IQADTLLDESEKKKPQ-QKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1743
Query: 860 DVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
V+ ++ ELN ++ A+ + + + + +Q+ +D + EP+ G
Sbjct: 1744 LVEPQISELNHRFAAISHRIKTGKASIPLK-ELEQFNSDIQKL------LEPLEAEIQQG 1796
Query: 920 ---KDEDSAEALLKKHEALMSDLSAYGSSIQAL-----REQAQSCRQQVAPTDDETGKEL 971
K+ED + + + +E + +L G ++Q + + +QQ+ T K+L
Sbjct: 1797 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1856
Query: 972 VLALYDYQEKSPREVT-------MKKGDILTLLNSTNK---------DWWKVEVNDRQGF 1015
+ K E++ + D+L L+ K D K++ DR+
Sbjct: 1857 ----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRE-- 1910
Query: 1016 VPAAYVKKLDPAQSASR--ENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELY 1073
KK + + R E L E+ ++A+ QI +S R +++E
Sbjct: 1911 ----LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----------LSKRWREIES-- 1953
Query: 1074 HSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAALTSEEVGADLEQV-EVLQK 1131
KF FR N Q + E+ + +E++ ++ V
Sbjct: 1954 -------------------KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT 1994
Query: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191
+ + L E L + A+D E E ++ ++ D SK +
Sbjct: 1995 EITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAA 2054
Query: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIE 1250
+SA V V ++ +L+ +W + ++ ++R S + +RFH D +W+
Sbjct: 2055 LQSAT-PVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2113
Query: 1251 EKNQALNT----DNYGHDLASVQALQRKHEGFERDLA-ALGDK---VNSLGETAERLIQ- 1301
E Q L +N+ H K++ + ++L +G + V +L T E +IQ
Sbjct: 2114 EAEQFLRKTQIPENWEH---------AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2164
Query: 1302 SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD-LQRFLSDFRDLMSWINGIRG 1360
S A LQEK LN W + K+ RK +L + + L F D + + W+
Sbjct: 2165 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2224
Query: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKL 1420
+ S + LE+ + E+ R G + + G +L ++P ++
Sbjct: 2225 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV----SAPISPEEQ 2280
Query: 1421 DILDQERADLEKAWVQ-RRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
D L+ + W++ R + ++ E++ +D Q E
Sbjct: 2281 DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE--------------------- 2319
Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
KK ED ++ +N + L +QL +I ++ N+
Sbjct: 2320 -----KKLEDLEEQLN---HLLLWLSPIRNQL---------EIYNQPNQ----------- 2351
Query: 1540 MIEKRSKLGESQTLQQFSR-DVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
E + E++ Q + DV+EI +S+ ++ P +L L S+ +
Sbjct: 2352 --EGPFDVQETEIAVQAKQPDVEEI---LSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 2406
Query: 1599 AFEAELHANA-DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQ 1657
EL A D G+ +G S + K + + K S
Sbjct: 2407 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTK----------ETAISKLEMPSS 2456
Query: 1658 KLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLEADISAHE 1716
+ E +FN + WLS ++ ++ S+ DL +N ++ K + D+
Sbjct: 2457 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2516
Query: 1717 DRLKDLNSQADSLM--TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR-LHQ 1773
+L++L + A +L TS+ + + D+ + I ++ +++ +RR +LNE + Q
Sbjct: 2517 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2576
Query: 1774 FFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTG 1832
+ ++ E + + + + S G + +Q + K+L +L + + D
Sbjct: 2577 WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA 2636
Query: 1833 KKLSDDNTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAW 1890
KL D + + + + W+ + + + R LEE+ QQF ++E+ AW
Sbjct: 2637 LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW 2696
Query: 1891 INEKMTLV-------ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIK 1943
+ E T E + ++ L+K+ + + + H D +++ N Q +++
Sbjct: 2697 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2756
Query: 1944 KNNHHEENI--SSKMKGLNGKVSDLEKAAAQRKAKLDENS-AFLQFNWKADVVESWIGEK 2000
++ + ++ +N K S+L K + ++ L+ +S + + + + W+ K
Sbjct: 2757 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2816
Query: 2001 ENSLKTD-DYGRDLSSVQT-----------LLTKQETFDAGLQAFQ-------QEGIANI 2041
++ L G D +VQ L TK+ + L+ + EG+ +
Sbjct: 2817 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 2876
Query: 2042 TALKDQLLAAKHVQS--KAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKVED 2096
+L + Q+ + + + + W +L +SA ++K+ LE ++ D
Sbjct: 2877 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 2936
Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA 2156
++A ++ + L D ++ + LE++KALR ++ + + + +
Sbjct: 2937 ELDLKLRQAEVIKGSWQPVGDLLIDSLQ-DHLEKVKALR-------GEIAPLKENVSHVN 2988
Query: 2157 ELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQR 2203
+L RQ+ + + +PY T+E L W+ LQ +++R +L + R
Sbjct: 2989 DLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHR 3035
Score = 179 bits (455), Expect = 2e-44
Identities = 457/2309 (19%), Positives = 880/2309 (38%), Gaps = 406/2309 (17%)
Query: 142 GIKLLQAQ-KLVQYLRECEDVMDWINDKEAIVTSE-ELGQDLEHVEVLQKKFEEFQTDMA 199
G L++++ L +Y E+V+ W+ E + ++ E+ D+E V+ E + D+
Sbjct: 323 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 382
Query: 200 AHEERVNEVNQFAAKLI---QEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAE 256
AH+ RV + Q +KLI + EE ++ + + +N+ W+ L+ ++++Q L
Sbjct: 383 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVL- 441
Query: 257 VQRFNRDVDETISWI---KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
+ N+ + E W+ +E+ + M + G DL ++ +++H+ L+ DL + +V +
Sbjct: 442 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 501
Query: 314 L---CAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLND-SYRLQRFLAD 369
L D H +A + Q+K L W I +R L D + QR +
Sbjct: 502 LTHMVVVVDESSGDHATAALEEQLK--VLGDRWANICRWTEDRWVLLQDILLKWQRLTEE 559
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
++W++E + +N H FK +E +L
Sbjct: 560 QCLFSAWLSEKEDAVN-------------------------KIHTTGFKDQNEMLSSL-- 592
Query: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
+KL VL + E ++Q + L+ T + + K EA+
Sbjct: 593 ----------QKLAVLKAD-------LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAW 635
Query: 490 LLN-EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
L N D+L V+ L K ++++ + +T T + V TR
Sbjct: 636 LDNFARCWDNL--VQKLEKSTAQISQAVTTTQPSLTQTTVMET---------VTTVTTRE 684
Query: 549 DALL--SRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK---MKTATDEAYKD 603
L+ ++ ++R DS ++ D EL SW+ +++ ++
Sbjct: 685 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 744
Query: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID--VNH--------YAKDEVAARM 653
N +K A E E + ++ ++ Q L++ VN A +++ +R
Sbjct: 745 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 804
Query: 654 NEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNV 713
E L + L E + + NQ QQ + E WL +++ S+ T +
Sbjct: 805 IEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWL-KIQPTTPSEP-----TAI 858
Query: 714 QNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGH----FDAENIKKKQEALVARYEAL 769
++ K ++ Q +I+ + IQ+ ++ G DA+ + A ++ +
Sbjct: 859 KSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFV-----AFTNHFKQV 913
Query: 770 KEPMVARKQKLA---DSLRLQQLFRDVEDEETWIREKE-PIAASTNRGKDLIGVQNLLKK 825
+ AR+++L D+L + + TW+++ E ++ D ++ L +
Sbjct: 914 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 973
Query: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEG-HFAAEDVKAKLHELNQKWEALKAKASQRRQ 884
QALQ+ + + + ++ M ++ + +++ E+ +W+ L ++ + Q
Sbjct: 974 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1033
Query: 885 DLEDSLQAQQYFAD--------ANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALM 936
LE+ + + + E + +++E+ P +G ++ K + LK+ L+
Sbjct: 1034 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ------LKQCRLLV 1087
Query: 937 SDLSAYGSSIQALREQAQSCRQQVAP---TDDETGKELVLALYDY--QEKSPREVTMKKG 991
SD+ S+ ++ E Q + + P + ET + + +D+ Q+ R+ +K G
Sbjct: 1088 SDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGG 1147
Query: 992 DILTLLNSTNKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSA------SRENLLEEQG 1040
L S KD W + + Y K D Q A ++E +++
Sbjct: 1148 --LEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-KTPDELQKAVEEMKRAKEEAQQKEA 1204
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEEL---YHSL-LELGEKRKGMLEKSCKKFML 1096
+ L E +++ +L+ K++E L Y L L K K + E L
Sbjct: 1205 KVKLLTESVNSVIAQAPPVAQEALK-KELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1263
Query: 1097 FREANELQQWINEKEAAL-TSEEVGADLEQV-EVLQKKFDDFQKDLKANESRLKDINKVA 1154
+ +W+NE E L T+E + E++ EVL D + ++ +E I +A
Sbjct: 1264 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL----DSLENLMRHSEDNPNQIRILA 1319
Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
+ L G+M E L+ + TFNS R
Sbjct: 1320 QTLTDGGVMDE-------------------------------LINEELETFNS------R 1342
Query: 1215 WRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRK 1274
WR L + A R +LL ++ + A ET++ S+ +Q
Sbjct: 1343 WRELHEEAVRRQKLL------EQSIQSAQETEK-------------------SLHLIQES 1377
Query: 1275 HEGFERDLAA-LGDKVNSLGETAE-RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRK 1332
++ LAA + DKV++ E + IQS S E E+ + NQ GK A QR
Sbjct: 1378 LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQ-----GKEAAQRV 1432
Query: 1333 AKLGD--SHDLQRFLSDFRDLMSWINGIRGLVSS----DELAKDVTGAEALLERHQEHRT 1386
D LQ FR N + L S DE+ + E + ++
Sbjct: 1433 LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQS 1492
Query: 1387 EIDARAGTFQAFEQF----------GQQLLAHGHYASP-EIKQKLDILDQERADLEKAWV 1435
+++ +++ + G+Q++ +P E+ +++ L +L
Sbjct: 1493 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVT 1552
Query: 1436 QRRMMLDQCLEL-QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
+R+ L++CL+L + ++ W+AA + L K +++ + + + + KA
Sbjct: 1553 ERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT---KRSAVEGMPSNLDSEVAWGKAT 1609
Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGE----- 1549
+ EK + + G K + + V D+ L + I S+ E
Sbjct: 1610 QKEIEK---QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLL 1666
Query: 1550 ---SQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHA 1606
+ ++ F ++VD I WI + T DES K K K + +AEL+
Sbjct: 1667 LEYQKHMETFDQNVDHITKWIIQ-ADTLLDESEK-------KKPQQKEDVLKRLKAELND 1718
Query: 1607 NADRIRGVIDM-GNSLIERGACAGSEDAVKARLAALADQWQFLVQ--KSAEKSQKLKEAN 1663
++ D N + RG V+ +++ L ++ + K+ + S LKE
Sbjct: 1719 IRPKVDSTRDQAANLMANRG--DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKEL- 1775
Query: 1664 KQQNFNTGIKDFDFWLSEVEA------LLASEDYGKDLASVNNLLKKHQLLEADISAHED 1717
+ FN+ I+ L +EA L ED+ KD+ N E
Sbjct: 1776 --EQFNSDIQKL---LEPLEAEIQQGVNLKEEDFNKDMNEDN----------------EG 1814
Query: 1718 RLKDLNSQADSLM--TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAK-LNESHRLHQF 1774
+K+L + D+L + ++K K+ + + +K + + RR K L SH+ +Q+
Sbjct: 1815 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1874
Query: 1775 FRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLR--KKHKRLEAELAAHEPAIQGVLDTG 1832
R DD LL +D + L + R +K K ++ EL + + V
Sbjct: 1875 KRQADD---------LLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1925
Query: 1833 KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWIN 1892
+ LS+D E Q Q + W+E++ A L + Q EE +
Sbjct: 1926 EGLSEDGAAMAVEPTQ--IQLSKRWREIESKFAQ-----FRRLNFAQIHTVREETMMVMT 1978
Query: 1893 EKMTLVASEDYGDTLAAI----QGLLKKHEAFETDFTVHKD-----RVNDVCTNGQDLIK 1943
E M L S L I Q LL+ + KD + + N +D ++
Sbjct: 1979 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2038
Query: 1944 KNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENS 2003
+++ + I SK K + L+ A + KL E + L F W EK N
Sbjct: 2039 QSSGRIDIIHSK------KTAALQSATPVERVKLQEALSQLDFQW----------EKVNK 2082
Query: 2004 LKTDDYGR-------------DLSSVQTLLTKQETFDAGLQAFQ--------------QE 2036
+ D GR D+ LT+ E F Q + Q+
Sbjct: 2083 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2142
Query: 2037 GIA-------NITALKDQLL-AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ 2088
GI + A ++++ + + ++ + SL RW ++ + RKK+L E
Sbjct: 2143 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ- 2201
Query: 2089 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA 2148
+++ F + + F W E A+ + P+ +++K E L
Sbjct: 2202 ------KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLR 2255
Query: 2149 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEE-------TWRNLQKIIKERELELQKE 2201
Q QL E + + S P + + LE W + + + E++ E++ +
Sbjct: 2256 QGILKQLNETGGPV----LVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQ 2311
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYL-------LDGSCMVEES--------GTL 2246
+ + +K ++ + N W+ R L +G V+E+ +
Sbjct: 2312 IKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDV 2371
Query: 2247 ESQLEATKRKHQEIRAMRSQLKKIEDLGA 2275
E L + ++E A + +K+EDL +
Sbjct: 2372 EEILSKGQHLYKEKPATQPVKRKLEDLSS 2400
Score = 157 bits (396), Expect = 2e-37
Identities = 438/2401 (18%), Positives = 922/2401 (38%), Gaps = 386/2401 (16%)
Query: 49 FQRDAEE---LEKWIQEKLQIASD---ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKL 102
+QR EE W+ EK + +KD + LQK +A+++ ++ KL
Sbjct: 553 WQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 612
Query: 103 DETGNLMISEGHFASETIRTR--LMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED 160
++S S T +T L R W+ L++K+ + ++ QA Q
Sbjct: 613 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 672
Query: 161 VMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQH 220
VM+ + VT+ E Q K QE+
Sbjct: 673 VMETVTT----VTTRE---------------------------------QILVKHAQEEL 695
Query: 221 PEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMAS 280
P K +Q V++ ++ R + D+ E SWI E ++ S
Sbjct: 696 PPPPPQKKRQITVDSEIRK-------------------RLDVDITELHSWITRSEAVLQS 736
Query: 281 DDFG--RDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ---SHPLSATQIQVK 335
+F R + L K +ER+ A K++ A L + + ++A I+
Sbjct: 737 PEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQA 796
Query: 336 REELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA-SDVA 394
E+L + W + L +ER L + F + L T + + S+
Sbjct: 797 SEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 856
Query: 395 GAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
++ L ++ + + + AL G + + + + +
Sbjct: 857 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSD 916
Query: 455 LWELRRQQYEQCMDL--QLFYRDT-EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
+ + R ++ + D + Y++T + W+ + E L L S+ E + ++ +
Sbjct: 917 V-QAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL--SVTDYEIMEQRLGE 973
Query: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA----LLSRRNALHERAMRRRA 567
+ S+ +E+ + L +T + + + A +++ + + + R L + +
Sbjct: 974 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1033
Query: 568 QLADSFH-LQQFFRDSDELKSWVNEKMKTATDE--AYKDPSNLQGKVQKHQAFEAELSAN 624
+L + + L++ LK W+ E +E A D L+ ++++ + +++
Sbjct: 1034 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1093
Query: 625 QSRIDALEKAGQKLIDVNHYAKDEVAARMN----EVISLWKKLLEATELKGIKLREANQQ 680
Q ++++ + GQK + + A+ E A+R+ E+ + W + + + L+ ++
Sbjct: 1094 QPSLNSVNEGGQK---IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1150
Query: 681 Q-QFNRNVEDIELWLYEVEG--------HLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+++ ++ W+ + E + D+ K + ++ +++ EA V
Sbjct: 1151 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1210
Query: 732 DRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL-QQLF 790
+ ++ + QA E +KK+ E L Y+ L + + + L + +L
Sbjct: 1211 ESVNSVIAQAPPVAQ------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELL 1264
Query: 791 RDVEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
+E W+ E E + + N + +L + L + +I+ + Q
Sbjct: 1265 SYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT--- 1321
Query: 850 MVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREK 909
+ +G E + +L N +W L +A +R++ LE S+Q+ Q + ++ ++E
Sbjct: 1322 -LTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ---ETEKSLHLIQES 1377
Query: 910 EPIVGS--TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
+ Y D+ A + ++ + + SDL+++ S++ +++ Q +
Sbjct: 1378 LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG----------KE 1427
Query: 968 GKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQGFVPAAYVKKLDP 1026
+ VL+ D +K ++V+MK N + K+ +++ + +PA K ++
Sbjct: 1428 AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1487
Query: 1027 AQSASR----ENLLEEQGSIALRQEQIDN------QTRITKEAGSVSLRMKQVEELYHSL 1076
S+ NL + + E + Q + T+ + R+ ++ Y+ L
Sbjct: 1488 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1547
Query: 1077 LELGEKRKGMLEKSCKKFMLFR-EANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDD 1135
+RK LEK K R E N L +W+ + LT VE + D
Sbjct: 1548 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA------VEGMPSNLDS 1601
Query: 1136 -------FQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
QK+++ + LK I +V E L++ ++ + ET
Sbjct: 1602 EVAWGKATQKEIEKQKVHLKSITEVGEALKT------------------VLGKKET---- 1639
Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEE-RSQLLGSAHEVQRFHRDADETKE 1247
+ + LN W ++ AEE + LL ++ F ++ D +
Sbjct: 1640 --------------LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 1685
Query: 1248 WIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGD---KVNSLGETAERLIQSHP 1304
WI + + L D + + Q+K + +R A L D KV+S + A L+ +
Sbjct: 1686 WIIQADTLL-------DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG 1738
Query: 1305 ESAEDLQE-KCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
+ L E + +ELN ++++ R KA + +L++F SD + L+ +
Sbjct: 1739 DHCRKLVEPQISELNHRFAAISHRIKTGKASI-PLKELEQFNSDIQKLLEPLEA------ 1791
Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GHYASPEIKQKLD 1421
E+ + V E + E GT + Q G L EIK K
Sbjct: 1792 --EIQQGVNLKEEDFNKDMNEDNE-----GTVKELLQRGDNLQQRITDERKREEIKIKQQ 1844
Query: 1422 ILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVE 1481
+L + L+ QRR L++ H+ W + +D LD +E
Sbjct: 1845 LLQTKHNALKDLRSQRRKKA-----LEISHQ-------WYQYKR---QADDLLKCLDDIE 1889
Query: 1482 ALI---------KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDR 1532
+ +K ++ D+ + ++E++ A++ A+ L G A + + ++ R
Sbjct: 1890 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDG--AAMAVEPTQIQLSKR 1947
Query: 1533 WRRLKAQMIE-KRSKLGESQTLQQFSRDV--DEIEAWIS--------------------E 1569
WR ++++ + +R + T+++ + V +++ IS E
Sbjct: 1948 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 2007
Query: 1570 KLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAG 1629
+L A D KD L + + + + L ++ RI +I + + A
Sbjct: 2008 QLLNAPDLCAKD-----FEDLFKQEESLKNIKDSLQQSSGRI-DIIHSKKTAALQSATPV 2061
Query: 1630 SEDAVKARLAALADQWQFLVQKSAEKSQKL-KEANKQQNFNTGIKDFDFWLSEVEALLAS 1688
++ L+ L QW+ + + ++ + + K + F+ IK F+ WL+E E L
Sbjct: 2062 ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK 2121
Query: 1689 EDYGKDL--ASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRD 1745
++ A LK+ L+ I + ++ LN+ + ++ SS D S +++K
Sbjct: 2122 TQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2178
Query: 1746 TINGRFQKIKSMAASRRAKLNESHR-LHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTG 1803
++N R+Q++ + R+ +L E L +F RD+++ W++E + + G++
Sbjct: 2179 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE--- 2235
Query: 1804 VQNLRKKHKRLEAELAAHEPAIQGVL----DTGKKLSDDNTIGKEE---IQQRLAQFVEH 1856
Q L++K ++++ L P QG+L +TG + I EE ++ +L Q
Sbjct: 2236 -QQLKEKLEQVKL-LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2293
Query: 1857 W-KELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLK 1915
W K + L +G+ + + Q +E+ E +N + ++ +
Sbjct: 2294 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG 2353
Query: 1916 KHEAFETDFTVHKDR--VNDVCTNGQDLIKKNNHHE------ENISSKMKGLNGKVSDLE 1967
+ ET+ V + V ++ + GQ L K+ + E++SS+ K +N + +L
Sbjct: 2354 PFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELR 2413
Query: 1968 ------------------------------KAAAQRKAKLD-----ENSAFLQFNWKADV 1992
K A K ++ E A FN
Sbjct: 2414 AKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTE 2473
Query: 1993 VESWIGEKENSLKTDDYG-RDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2051
+ W+ + +K+ DL + ++ KQ+ A +Q +Q L++ + AA
Sbjct: 2474 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK---ATMQDLEQRR----PQLEELITAA 2526
Query: 2052 KHVQSKA--------IEARHASLMKRWSQLLANSAARKKKLLE----AQSHFRKVEDLFL 2099
+++++K I R + +W ++ + R+++L E + E+
Sbjct: 2527 QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 2586
Query: 2100 TFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELD 2159
+ + SW E D ++ + E K L + +++++ A N LA
Sbjct: 2587 VLGQARAKLESWKEGPYT--VDAIQ-KKITETKQLAKDLRQWQTNVDVA----NDLAL-- 2637
Query: 2160 RQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHA 2219
+ ++ + E + +WR++ K + ERE L EE +L Q+F
Sbjct: 2638 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL-------EETHRLLQQFPLDL 2690
Query: 2220 NAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKH--QEIRAMRSQLKKIEDLGAAM 2277
F W+ E T T +AT+++ ++ + ++ +K+ +DL +
Sbjct: 2691 EKFLAWLTEAET-------------TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2737
Query: 2278 E 2278
E
Sbjct: 2738 E 2738
Score = 116 bits (291), Expect = 2e-25
Identities = 398/2188 (18%), Positives = 823/2188 (37%), Gaps = 388/2188 (17%)
Query: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINAD-ELASDVAGAEALLDRHQEHKGEIDAHED 415
+ L R+ ++ SW+ + + A E+++DV + H+ + ++ AH+
Sbjct: 327 MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQG 386
Query: 416 SFKSADESGQALLAAGHYASDE---VREKLTVLSEERAAL-LELWELRRQQYEQCMDLQL 471
+ + G L+ G + DE V+E++ +L+ L + E + + MDLQ
Sbjct: 387 RVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ- 445
Query: 472 FYRDTEQVDNWMSKQEAF---LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528
+ +++++W++K E + E LG L+ ++ +++H+ ++ L ++ ++ +L
Sbjct: 446 -NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTH 504
Query: 529 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHL--QQFFRDSDELK 586
+ +++ + +L R A R R L L Q+ +
Sbjct: 505 MVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 564
Query: 587 SWVNEKMKTATD---EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNH 643
+W++EK +KD + + +QK +A+L EK Q
Sbjct: 565 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADL----------EKKKQS------ 608
Query: 644 YAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLAS 703
M ++ SL + LL + K + + E WL
Sbjct: 609 ---------MGKLYSLKQDLLSTLKNKSV--------------TQKTEAWL--------- 636
Query: 704 DDYGKDLTN-VQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEAL 762
D++ + N VQ L+K A + V Q + T+ + +++ L
Sbjct: 637 DNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET---------VTTVTTREQIL 687
Query: 763 V--ARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG--KDLIG 818
V A+ E P ++Q DS ++L D+ + +WI E + S +
Sbjct: 688 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGN 747
Query: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE---GHFAAEDVKAKLHELNQKWEAL 875
+L +K A++ E A +++ ++ A+VE+ A+ +K +LN +W
Sbjct: 748 FSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEF 807
Query: 876 KAKASQRRQDLEDSL-------QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEAL 928
S+R LE Q QQ AE+W++ +P S + + ++
Sbjct: 808 CQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI-QPTTPS-----EPTAIKSQ 861
Query: 929 LKKHEALMSDLSAYGSSIQALREQAQSCRQQ-VAPTDDETGKELVLALYDYQEKSPREVT 987
LK + ++ LS I+ L+ Q+ + +++ P + +A ++ ++ +V
Sbjct: 862 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDAD---FVAFTNHFKQVFSDVQ 918
Query: 988 MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQ-GSIALRQ 1046
++ ++ T+ ++ ++ ++ + +V + K P S + ++E++ G + Q
Sbjct: 919 AREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQ 978
Query: 1047 EQIDNQT-----------RITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
+ Q ++K+A S R Q E + + +K L + C+K
Sbjct: 979 SSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE--FEEIEGRWKKLSSQLVEHCQK-- 1034
Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAE 1155
L + N+L++ N ++ L+K + LK L D + +
Sbjct: 1035 LEEQMNKLRKIQNH----------------IQTLKKWMAEVDVFLKEEWPALGDSEILKK 1078
Query: 1156 DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERW 1215
L+ L+ ++Q +Q + + + A P ++RL +KELN +W
Sbjct: 1079 QLKQCRLLVSDIQTIQPS-LNSVNEGGQKIKNEAEPEFASRLETE-------LKELNTQW 1130
Query: 1216 RSL-QQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA-----SVQ 1269
+ QQ+ + L G + +D E EW+ + + ++ + +V+
Sbjct: 1131 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1190
Query: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAED-------------------L 1310
++R E ++ A KV L E+ +I P A++ L
Sbjct: 1191 EMKRAKEEAQQKEA----KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL 1246
Query: 1311 QEKCTELNQAWS----------SLGKRADQRKAKL-------GDSHDLQRFLSDFRDLMS 1353
KC L + W+ K ++ + KL G + ++ L +LM
Sbjct: 1247 NGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMR 1306
Query: 1354 WI----NGIRGLVSS----------------------DELAKDVTGAEALLERH------ 1381
N IR L + EL ++ + LLE+
Sbjct: 1307 HSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE 1366
Query: 1382 --------QEHRTEIDARAGTF-----------QAFEQFGQQLLAHGHYASPEIKQKLDI 1422
QE T ID + + Q ++ L +H + E+K+
Sbjct: 1367 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSH-EISLEEMKKHNQG 1425
Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDC--EQA--ENWMAAREAFLNT---EDKGD 1475
+ + L + V ++ + D ++ +LF + EQ E+ M E ++ E K
Sbjct: 1426 KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSV 1485
Query: 1476 SLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG-DISSRRNEVLDRWR 1534
+ V++ + + K+++ + ++ + Q++ ++ R + +
Sbjct: 1486 EQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 1545
Query: 1535 RLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
L A++ E++ +L + L ++ ++++ + W++ T + + + S L S+
Sbjct: 1546 ELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA---TDMELTKRSAVEGMPSNLDSE 1602
Query: 1594 HQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSA 1653
+A + E+ ++ + ++G +L + E V+ +L+ L W + ++
Sbjct: 1603 VAWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAE 1660
Query: 1654 EKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI 1712
E L E K + F+ + W+ + + LL E K ++LK+ L+A++
Sbjct: 1661 EWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-DESEKKKPQQKEDVLKR---LKAEL 1716
Query: 1713 SAHEDRLKDLNSQADSLMTSSAFDTSQ-VKDKRDTINGRFQKIKSMAASRRAKLNESHRL 1771
+ ++ QA +LM + + V+ + +N RF I + +A + L
Sbjct: 1717 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-PLKEL 1775
Query: 1772 HQFFRD----MDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
QF D ++ E+ I++ L ED+ +D+ +E ++
Sbjct: 1776 EQFNSDIQKLLEPLEAEIQQGVNLK-EEDFNKDMN----------------EDNEGTVKE 1818
Query: 1828 VLDTG----KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQR-LEESLEYQQFVA 1882
+L G ++++D+ + +I+Q+L Q +H LK L + R ++ LE S ++ Q+
Sbjct: 1819 LLQRGDNLQQRITDERKREEIKIKQQLLQ-TKH-NALKDLRSQRRKKALEISHQWYQYKR 1876
Query: 1883 NVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLI 1942
++ L +D LA++ + + E D + K + + +
Sbjct: 1877 QADD---------LLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK---------EEL 1918
Query: 1943 KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWKADVVESWIGEKE 2001
E +S +G +E Q + E S F QF + E+
Sbjct: 1919 NAVRRQAEGLSE-----DGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREET 1973
Query: 2002 NSLKTDDYGRDLSSV------------QTLLTKQETFDAG-------LQAFQQEGIANIT 2042
+ T+D ++S V Q LL ++ +A F+QE ++
Sbjct: 1974 MMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE--ESLK 2031
Query: 2043 ALKDQLLAAKH----VQSK-------AIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
+KD L + + SK A L + SQL K + Q F
Sbjct: 2032 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 2091
Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA---LREAHDAF------- 2141
+ + + F FN W AE+ L + E K L+E D
Sbjct: 2092 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2151
Query: 2142 RSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKE 2201
R+ ++ + Q ++ D I ++ S W Q++ K+ L
Sbjct: 2152 RTLNATGEEIIQQSSKTDASILQEKLGSLNLRW-------------QEVCKQ----LSDR 2194
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVE--ESGTLESQLEATKRKHQE 2259
++R EE + EF + N F W++E S +E + L+ +LE K +E
Sbjct: 2195 KKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASIPLEPGKEQQLKEKLEQVKLLVEE 2251
Query: 2260 IRAMRSQLKKIEDLGAAM--------EEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQH 2311
+ + LK++ + G + EE L+NK + + QW ++ + Q
Sbjct: 2252 LPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL-----QWIKVSRALPEKQG 2306
Query: 2312 NLEQQIQARNTTGVTEEALKEFSMMFKH 2339
+E QI+ G E+ L++ H
Sbjct: 2307 EIEAQIK---DLGQLEKKLEDLEEQLNH 2331
Score = 109 bits (272), Expect = 4e-23
Identities = 195/995 (19%), Positives = 413/995 (41%), Gaps = 111/995 (11%)
Query: 13 EDIQERRQQVLDRYHRFKELSTLRRQK-LEDSYRFQFFQRDAEELEKWIQE-KLQIASDE 70
E+I+ ++Q + +++ K+L + RR+K LE S+++ ++R A++L K + + + ++AS
Sbjct: 1837 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1896
Query: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS-----ETIRTRLM 125
+D ++ ++ Q + E+ A L E G M E I ++
Sbjct: 1897 EPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFA 1956
Query: 126 ELHRQWELLLEKMREKGIKLLQAQKLVQ-------YLRECEDVMDWINDKEAIVTSEEL- 177
+ R + +RE+ + ++ ++ YL E V + + E ++ + +L
Sbjct: 1957 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 2016
Query: 178 GQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAA 236
+D E + ++ + + + R++ ++ +Q P E + ++ +++
Sbjct: 2017 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ 2076
Query: 237 WQRLKGLALQRQGKLFGAAEV-QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLR 295
W+++ + RQG+ + E +RF+ D+ W+ E EQ + + +
Sbjct: 2077 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2136
Query: 296 KHEGLERDLAALEDKVKALCAEADR-LQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354
E L+ + + V+ L A + +QQS A+ +Q K L W+++ ++R
Sbjct: 2137 LKE-LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2195
Query: 355 ARLNDSYRLQRFLADF-RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHK---GEI 410
RL + + L++F RDL +V ++ N + + + L ++ ++ K E+
Sbjct: 2196 KRLEEQ---KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 2252
Query: 411 DAHEDSFKSADESGQALLAAGHYA---SDEVREKLTVLS---------------EERAAL 452
+ K +E+G +L + + D++ KL + E A +
Sbjct: 2253 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2312
Query: 453 LELWELRRQ---QYEQCMDLQLF---YRDTEQVDNWMSKQEAFLLNED---LGDSLDSVE 503
+L +L ++ EQ L L+ R+ ++ N +++ F + E + VE
Sbjct: 2313 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2372
Query: 504 ALLKKHEDFEKSLSAQEEKITALDEFAT------KLIQNNHYAMEDVA----------TR 547
+L K + K A + L++ ++ +L+Q D+A T+
Sbjct: 2373 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2432
Query: 548 RDALLSRRNALHERAMRRRAQLADSFHLQ-----QFFRDSDELKSWVN--EKMKTATDEA 600
L+++ E A+ + ++ S L+ F R EL W++ +++ +
Sbjct: 2433 TVTLVTQPVVTKETAI-SKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2491
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID--VNHYAKDEVAARMNEVIS 658
D ++ + K +A +L + +++ L A Q L + N A+ + R+ + +
Sbjct: 2492 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2551
Query: 659 LWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVE--------GHLASDDYGKDL 710
W ++ E + N++QQ N ++D WL E + + +
Sbjct: 2552 QWDEVQEHLQ---------NRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2602
Query: 711 TNVQNLQKK---HALLEADVAAHQDRID-GITIQARQFQDAGHFDAENIKKKQEALVARY 766
V +QKK L D+ Q +D + + +D D + E + A +
Sbjct: 2603 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW 2662
Query: 767 EALKEPMVARKQKLADSLRLQQLF-RDVEDEETWIREKEPIA----ASTNRGK---DLIG 818
++ + + R+ L ++ RL Q F D+E W+ E E A +T + + D G
Sbjct: 2663 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG 2722
Query: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE--EGHFAAEDVKAKLHELNQKWEALK 876
V+ L+K+ Q LQ EI H + + ++ EG A ++ +L +N KW L+
Sbjct: 2723 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR 2782
Query: 877 AKASQRRQDLE-DSLQAQQYFADANEAESWMREKE 910
K+ R LE S Q ++ E W++ K+
Sbjct: 2783 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 2817
Score = 100 bits (248), Expect = 2e-20
Identities = 181/943 (19%), Positives = 381/943 (40%), Gaps = 133/943 (14%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD--ENYKDPTNLQGKLQKHQA 87
K+LS +++ E FQRD E W++E IAS E K+ L+ KL++ +
Sbjct: 2189 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ-QLKEKLEQVKL 2247
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASET---IRTRLMELHRQWELLLEKMREKGIK 144
E+ G + +L+ETG ++ + E + +L + + QW + + EK +
Sbjct: 2248 LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE 2307
Query: 145 L-LQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
+ Q + L Q ++ ED+ E+L L + ++ + E +
Sbjct: 2308 IEAQIKDLGQLEKKLEDL------------EEQLNHLLLWLSPIRNQLEIY--------- 2346
Query: 204 RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
N+ NQ +QE E ++ KQ +V + + L ++ Q R
Sbjct: 2347 --NQPNQEGPFDVQET---EIAVQAKQPDVEEILSKGQHLYKEKPA-------TQPVKRK 2394
Query: 264 VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
++ D + +V LL++ + DLA + A + L
Sbjct: 2395 LE----------------DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL-- 2436
Query: 324 SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFR----DLTSWVTE 379
TQ V +E I+ E +L E A LADF +LT W++
Sbjct: 2437 -----VTQPVVTKETAISKLEMPSSLMLEVPA-----------LADFNRAWTELTDWLSL 2480
Query: 380 MKALINADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASD 436
+ +I + + D+ ++ + + +++ + + Q L + A
Sbjct: 2481 LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART 2540
Query: 437 EVREKLTVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLLNEDL 495
+ +++ + + + E + RRQQ + + D + E+ + + + A L +
Sbjct: 2541 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE 2600
Query: 496 GD-SLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSR 554
G ++D+++ + + + K L + + ++ A KL+++ Y+ +D TR+ +++
Sbjct: 2601 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD--YSADD--TRKVHMITE 2656
Query: 555 R-----NALHERAMRRRAQLADSFHL-QQFFRDSDELKSWVNEKMKTAT--------DEA 600
++H+R R A L ++ L QQF D ++ +W+ E TA +
Sbjct: 2657 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 2716
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA--RMNEVIS 658
+D ++ +++ Q + E+ A+ L++ QK++ + D V R++ +
Sbjct: 2717 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2776
Query: 659 LWKKLLEAT-ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNL 716
W +L + + ++ ++Q ++ + +++++ +WL + L+ G D VQ
Sbjct: 2777 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2836
Query: 717 QKKHALLEADVAAHQDRIDGITIQARQFQDAGHFD-----------------AENI---- 755
H + ++ + I R F + A+N+
Sbjct: 2837 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2896
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGK 814
+K+ E + +E L ++K+ ++L RLQ+L ++ + +R+ E I S
Sbjct: 2897 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 2956
Query: 815 DLI--GVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKW 872
DL+ +Q+ L+K +AL+ EIA + + V + G + + L +LN +W
Sbjct: 2957 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 3016
Query: 873 EALKAKASQRRQDLEDSLQ----AQQYFADANEAESWMREKEP 911
+ L+ R + L ++ + A Q+F + W R P
Sbjct: 3017 KLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISP 3059
>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
Length = 3562
Score = 186 bits (473), Expect = 2e-46
Identities = 439/2327 (18%), Positives = 908/2327 (39%), Gaps = 344/2327 (14%)
Query: 19 RQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE---KLQIASDENYKDP 75
+Q D R KEL T+ D+ +Q + W+Q+ KL I + D
Sbjct: 796 KQVFSDVQAREKELQTIF-----DTLPPMRYQETMSAIRTWVQQSETKLSIPQ-LSVTDY 849
Query: 76 TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFA-SETIRTRLMELHRQWELL 134
++ +L + QA ++ +Q + L T M + S ++ E+ +W+ L
Sbjct: 850 EIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKL 909
Query: 135 LEKMREKGIKLL-QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
++ E KL Q KL + + + W+ + + + E L E+L+K+ ++
Sbjct: 910 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEE--WPALGDSEILKKQLKQ 967
Query: 194 FQ---TDMAAHEERVNEVNQFAAKLIQEQHPE-EELIKTKQDEVNAAWQRLKGLALQRQG 249
+ +D+ + +N VN+ K+ E PE ++T+ E+N W + R+
Sbjct: 968 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKE 1027
Query: 250 KLFGAAE-VQRFNRDVDETISWIKEKEQLMASDDFG-RDLASVQALLRKHEGLERDLAAL 307
L G E +D+ E W+ + E+ DF + +Q + + + + +
Sbjct: 1028 ALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQK 1087
Query: 308 EDKVKALCAEADR-LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR-LQR 365
E KVK L + + Q+ P++ ++ + E L TN++ + T RLN + L+
Sbjct: 1088 EAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCT-------RLNGKCKTLEE 1140
Query: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
A + +L S++ + +N E+ + E + +E +D+ E+ + ++++
Sbjct: 1141 VWACWHELLSYLEKANKWLN--EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1198
Query: 426 AL------LAAGHYASDEVREKLTV-------LSEE---RAALLELWELRRQQYEQCM-- 467
+ L G + + E+L L EE R LLE Q+ E+ +
Sbjct: 1199 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1258
Query: 468 --------DLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQ 519
D QL ++VD QEA + DL S+E + K ++ E A
Sbjct: 1259 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKE----AA 1314
Query: 520 EEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFF 579
+ ++ +D KL +DV+ + L ++ A E+ ++ + D +
Sbjct: 1315 QRVLSQIDVAQKKL--------QDVSMK--FRLFQKPANFEQRLQESKMILDEVKMHLPA 1364
Query: 580 RDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLI 639
++ ++ V + YK LS +S ++ + K G++++
Sbjct: 1365 LETKSVEQEVVQSQLNHCVNLYKS-----------------LSEVKSEVEMVIKTGRQIV 1407
Query: 640 DVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ--------QQFNRNVEDIE 691
+ E ++E ++ K L EL G K+ E QQ ++ + + +
Sbjct: 1408 QKK---QTENPKELDERVTALK--LHYNEL-GAKVTERKQQLEKCLKLSRKMRKEMNVLT 1461
Query: 692 LWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA---AHQDRIDGITIQARQFQDAG 748
WL + +LT ++ + L+++VA A Q I+ + + + G
Sbjct: 1462 EWLAATD---------MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1512
Query: 749 HFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL--------QQLFRDVEDEETWI 800
+ KK+ + + L +A + + L L + ++V+ WI
Sbjct: 1513 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 1572
Query: 801 REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT-QKGNAMVEEGHFAAE 859
+ + + + + K +++LK+ L+AE+ P++ + Q N M G +
Sbjct: 1573 IQADTLLDESEKKKPQ-QKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1628
Query: 860 DVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
V+ ++ ELN ++ A+ + + + + +Q+ +D + EP+ G
Sbjct: 1629 LVEPQISELNHRFAAISHRIKTGKASIPLK-ELEQFNSDIQKL------LEPLEAEIQQG 1681
Query: 920 ---KDEDSAEALLKKHEALMSDLSAYGSSIQAL-----REQAQSCRQQVAPTDDETGKEL 971
K+ED + + + +E + +L G ++Q + + +QQ+ T K+L
Sbjct: 1682 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1741
Query: 972 VLALYDYQEKSPREVT-------MKKGDILTLLNSTNK---------DWWKVEVNDRQGF 1015
+ K E++ + D+L L+ K D K++ DR+
Sbjct: 1742 ----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRE-- 1795
Query: 1016 VPAAYVKKLDPAQSASR--ENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELY 1073
KK + + R E L E+ ++A+ QI +S R +++E
Sbjct: 1796 ----LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----------LSKRWREIES-- 1838
Query: 1074 HSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAALTSEEVGADLEQV-EVLQK 1131
KF FR N Q + E+ + +E++ ++ V
Sbjct: 1839 -------------------KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT 1879
Query: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191
+ + L E L + A+D E E ++ ++ D SK +
Sbjct: 1880 EITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAA 1939
Query: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIE 1250
+SA V V ++ +L+ +W + ++ ++R S + +RFH D +W+
Sbjct: 1940 LQSAT-PVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 1998
Query: 1251 EKNQALNT----DNYGHDLASVQALQRKHEGFERDLA-ALGDK---VNSLGETAERLIQ- 1301
E Q L +N+ H K++ + ++L +G + V +L T E +IQ
Sbjct: 1999 EAEQFLRKTQIPENWEH---------AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2049
Query: 1302 SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD-LQRFLSDFRDLMSWINGIRG 1360
S A LQEK LN W + K+ RK +L + + L F D + + W+
Sbjct: 2050 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2109
Query: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKL 1420
+ S + LE+ + E+ R G + + G +L ++P ++
Sbjct: 2110 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV----SAPISPEEQ 2165
Query: 1421 DILDQERADLEKAWVQ-RRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
D L+ + W++ R + ++ E++ +D Q E
Sbjct: 2166 DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE--------------------- 2204
Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
KK ED ++ +N + L +QL +I ++ N+
Sbjct: 2205 -----KKLEDLEEQLN---HLLLWLSPIRNQL---------EIYNQPNQ----------- 2236
Query: 1540 MIEKRSKLGESQTLQQFSR-DVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
E + E++ Q + DV+EI +S+ ++ P +L L S+ +
Sbjct: 2237 --EGPFDVQETEIAVQAKQPDVEEI---LSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 2291
Query: 1599 AFEAELHANA-DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQ 1657
EL A D G+ +G S + K + + K S
Sbjct: 2292 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTK----------ETAISKLEMPSS 2341
Query: 1658 KLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLEADISAHE 1716
+ E +FN + WLS ++ ++ S+ DL +N ++ K + D+
Sbjct: 2342 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2401
Query: 1717 DRLKDLNSQADSLM--TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR-LHQ 1773
+L++L + A +L TS+ + + D+ + I ++ +++ +RR +LNE + Q
Sbjct: 2402 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2461
Query: 1774 FFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTG 1832
+ ++ E + + + + S G + +Q + K+L +L + + D
Sbjct: 2462 WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA 2521
Query: 1833 KKLSDDNTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAW 1890
KL D + + + + W+ + + + R LEE+ QQF ++E+ AW
Sbjct: 2522 LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW 2581
Query: 1891 INEKMTLV-------ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIK 1943
+ E T E + ++ L+K+ + + + H D +++ N Q +++
Sbjct: 2582 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2641
Query: 1944 KNNHHEENI--SSKMKGLNGKVSDLEKAAAQRKAKLDENS-AFLQFNWKADVVESWIGEK 2000
++ + ++ +N K S+L K + ++ L+ +S + + + + W+ K
Sbjct: 2642 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2701
Query: 2001 ENSLKTD-DYGRDLSSVQT-----------LLTKQETFDAGLQAFQ-------QEGIANI 2041
++ L G D +VQ L TK+ + L+ + EG+ +
Sbjct: 2702 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 2761
Query: 2042 TALKDQLLAAKHVQS--KAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKVED 2096
+L + Q+ + + + + W +L +SA ++K+ LE ++ D
Sbjct: 2762 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 2821
Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA 2156
++A ++ + L D ++ + LE++KALR ++ + + + +
Sbjct: 2822 ELDLKLRQAEVIKGSWQPVGDLLIDSLQ-DHLEKVKALR-------GEIAPLKENVSHVN 2873
Query: 2157 ELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQR 2203
+L RQ+ + + +PY T+E L W+ LQ +++R +L + R
Sbjct: 2874 DLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHR 2920
Score = 179 bits (455), Expect = 2e-44
Identities = 457/2309 (19%), Positives = 880/2309 (38%), Gaps = 406/2309 (17%)
Query: 142 GIKLLQAQ-KLVQYLRECEDVMDWINDKEAIVTSE-ELGQDLEHVEVLQKKFEEFQTDMA 199
G L++++ L +Y E+V+ W+ E + ++ E+ D+E V+ E + D+
Sbjct: 208 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 267
Query: 200 AHEERVNEVNQFAAKLI---QEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAE 256
AH+ RV + Q +KLI + EE ++ + + +N+ W+ L+ ++++Q L
Sbjct: 268 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVL- 326
Query: 257 VQRFNRDVDETISWI---KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
+ N+ + E W+ +E+ + M + G DL ++ +++H+ L+ DL + +V +
Sbjct: 327 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 386
Query: 314 L---CAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLND-SYRLQRFLAD 369
L D H +A + Q+K L W I +R L D + QR +
Sbjct: 387 LTHMVVVVDESSGDHATAALEEQLK--VLGDRWANICRWTEDRWVLLQDILLKWQRLTEE 444
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
++W++E + +N H FK +E +L
Sbjct: 445 QCLFSAWLSEKEDAVN-------------------------KIHTTGFKDQNEMLSSL-- 477
Query: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
+KL VL + E ++Q + L+ T + + K EA+
Sbjct: 478 ----------QKLAVLKAD-------LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAW 520
Query: 490 LLN-EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
L N D+L V+ L K ++++ + +T T + V TR
Sbjct: 521 LDNFARCWDNL--VQKLEKSTAQISQAVTTTQPSLTQTTVMET---------VTTVTTRE 569
Query: 549 DALL--SRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK---MKTATDEAYKD 603
L+ ++ ++R DS ++ D EL SW+ +++ ++
Sbjct: 570 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 629
Query: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID--VNH--------YAKDEVAARM 653
N +K A E E + ++ ++ Q L++ VN A +++ +R
Sbjct: 630 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 689
Query: 654 NEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNV 713
E L + L E + + NQ QQ + E WL +++ S+ T +
Sbjct: 690 IEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWL-KIQPTTPSEP-----TAI 743
Query: 714 QNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGH----FDAENIKKKQEALVARYEAL 769
++ K ++ Q +I+ + IQ+ ++ G DA+ + A ++ +
Sbjct: 744 KSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFV-----AFTNHFKQV 798
Query: 770 KEPMVARKQKLA---DSLRLQQLFRDVEDEETWIREKE-PIAASTNRGKDLIGVQNLLKK 825
+ AR+++L D+L + + TW+++ E ++ D ++ L +
Sbjct: 799 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 858
Query: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEG-HFAAEDVKAKLHELNQKWEALKAKASQRRQ 884
QALQ+ + + + ++ M ++ + +++ E+ +W+ L ++ + Q
Sbjct: 859 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 918
Query: 885 DLEDSLQAQQYFAD--------ANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALM 936
LE+ + + + E + +++E+ P +G ++ K + LK+ L+
Sbjct: 919 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ------LKQCRLLV 972
Query: 937 SDLSAYGSSIQALREQAQSCRQQVAP---TDDETGKELVLALYDY--QEKSPREVTMKKG 991
SD+ S+ ++ E Q + + P + ET + + +D+ Q+ R+ +K G
Sbjct: 973 SDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGG 1032
Query: 992 DILTLLNSTNKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSA------SRENLLEEQG 1040
L S KD W + + Y K D Q A ++E +++
Sbjct: 1033 --LEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-KTPDELQKAVEEMKRAKEEAQQKEA 1089
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEEL---YHSL-LELGEKRKGMLEKSCKKFML 1096
+ L E +++ +L+ K++E L Y L L K K + E L
Sbjct: 1090 KVKLLTESVNSVIAQAPPVAQEALK-KELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1148
Query: 1097 FREANELQQWINEKEAAL-TSEEVGADLEQV-EVLQKKFDDFQKDLKANESRLKDINKVA 1154
+ +W+NE E L T+E + E++ EVL D + ++ +E I +A
Sbjct: 1149 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL----DSLENLMRHSEDNPNQIRILA 1204
Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
+ L G+M E L+ + TFNS R
Sbjct: 1205 QTLTDGGVMDE-------------------------------LINEELETFNS------R 1227
Query: 1215 WRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRK 1274
WR L + A R +LL ++ + A ET++ S+ +Q
Sbjct: 1228 WRELHEEAVRRQKLL------EQSIQSAQETEK-------------------SLHLIQES 1262
Query: 1275 HEGFERDLAA-LGDKVNSLGETAE-RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRK 1332
++ LAA + DKV++ E + IQS S E E+ + NQ GK A QR
Sbjct: 1263 LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQ-----GKEAAQRV 1317
Query: 1333 AKLGD--SHDLQRFLSDFRDLMSWINGIRGLVSS----DELAKDVTGAEALLERHQEHRT 1386
D LQ FR N + L S DE+ + E + ++
Sbjct: 1318 LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQS 1377
Query: 1387 EIDARAGTFQAFEQF----------GQQLLAHGHYASP-EIKQKLDILDQERADLEKAWV 1435
+++ +++ + G+Q++ +P E+ +++ L +L
Sbjct: 1378 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVT 1437
Query: 1436 QRRMMLDQCLEL-QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
+R+ L++CL+L + ++ W+AA + L K +++ + + + + KA
Sbjct: 1438 ERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT---KRSAVEGMPSNLDSEVAWGKAT 1494
Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGE----- 1549
+ EK + + G K + + V D+ L + I S+ E
Sbjct: 1495 QKEIEK---QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLL 1551
Query: 1550 ---SQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHA 1606
+ ++ F ++VD I WI + T DES K K K + +AEL+
Sbjct: 1552 LEYQKHMETFDQNVDHITKWIIQ-ADTLLDESEK-------KKPQQKEDVLKRLKAELND 1603
Query: 1607 NADRIRGVIDM-GNSLIERGACAGSEDAVKARLAALADQWQFLVQ--KSAEKSQKLKEAN 1663
++ D N + RG V+ +++ L ++ + K+ + S LKE
Sbjct: 1604 IRPKVDSTRDQAANLMANRG--DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKEL- 1660
Query: 1664 KQQNFNTGIKDFDFWLSEVEA------LLASEDYGKDLASVNNLLKKHQLLEADISAHED 1717
+ FN+ I+ L +EA L ED+ KD+ N E
Sbjct: 1661 --EQFNSDIQKL---LEPLEAEIQQGVNLKEEDFNKDMNEDN----------------EG 1699
Query: 1718 RLKDLNSQADSLM--TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAK-LNESHRLHQF 1774
+K+L + D+L + ++K K+ + + +K + + RR K L SH+ +Q+
Sbjct: 1700 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1759
Query: 1775 FRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLR--KKHKRLEAELAAHEPAIQGVLDTG 1832
R DD LL +D + L + R +K K ++ EL + + V
Sbjct: 1760 KRQADD---------LLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1810
Query: 1833 KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWIN 1892
+ LS+D E Q Q + W+E++ A L + Q EE +
Sbjct: 1811 EGLSEDGAAMAVEPTQ--IQLSKRWREIESKFAQ-----FRRLNFAQIHTVREETMMVMT 1863
Query: 1893 EKMTLVASEDYGDTLAAI----QGLLKKHEAFETDFTVHKD-----RVNDVCTNGQDLIK 1943
E M L S L I Q LL+ + KD + + N +D ++
Sbjct: 1864 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 1923
Query: 1944 KNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENS 2003
+++ + I SK K + L+ A + KL E + L F W EK N
Sbjct: 1924 QSSGRIDIIHSK------KTAALQSATPVERVKLQEALSQLDFQW----------EKVNK 1967
Query: 2004 LKTDDYGR-------------DLSSVQTLLTKQETFDAGLQAFQ--------------QE 2036
+ D GR D+ LT+ E F Q + Q+
Sbjct: 1968 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2027
Query: 2037 GIA-------NITALKDQLL-AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ 2088
GI + A ++++ + + ++ + SL RW ++ + RKK+L E
Sbjct: 2028 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ- 2086
Query: 2089 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA 2148
+++ F + + F W E A+ + P+ +++K E L
Sbjct: 2087 ------KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLR 2140
Query: 2149 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEE-------TWRNLQKIIKERELELQKE 2201
Q QL E + + S P + + LE W + + + E++ E++ +
Sbjct: 2141 QGILKQLNETGGPV----LVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQ 2196
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYL-------LDGSCMVEES--------GTL 2246
+ + +K ++ + N W+ R L +G V+E+ +
Sbjct: 2197 IKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDV 2256
Query: 2247 ESQLEATKRKHQEIRAMRSQLKKIEDLGA 2275
E L + ++E A + +K+EDL +
Sbjct: 2257 EEILSKGQHLYKEKPATQPVKRKLEDLSS 2285
Score = 157 bits (396), Expect = 2e-37
Identities = 438/2401 (18%), Positives = 922/2401 (38%), Gaps = 386/2401 (16%)
Query: 49 FQRDAEE---LEKWIQEKLQIASD---ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKL 102
+QR EE W+ EK + +KD + LQK +A+++ ++ KL
Sbjct: 438 WQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 497
Query: 103 DETGNLMISEGHFASETIRTR--LMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED 160
++S S T +T L R W+ L++K+ + ++ QA Q
Sbjct: 498 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 557
Query: 161 VMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQH 220
VM+ + VT+ E Q K QE+
Sbjct: 558 VMETVTT----VTTRE---------------------------------QILVKHAQEEL 580
Query: 221 PEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMAS 280
P K +Q V++ ++ R + D+ E SWI E ++ S
Sbjct: 581 PPPPPQKKRQITVDSEIRK-------------------RLDVDITELHSWITRSEAVLQS 621
Query: 281 DDFG--RDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ---SHPLSATQIQVK 335
+F R + L K +ER+ A K++ A L + + ++A I+
Sbjct: 622 PEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQA 681
Query: 336 REELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA-SDVA 394
E+L + W + L +ER L + F + L T + + S+
Sbjct: 682 SEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 741
Query: 395 GAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
++ L ++ + + + AL G + + + + +
Sbjct: 742 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSD 801
Query: 455 LWELRRQQYEQCMDL--QLFYRDT-EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
+ + R ++ + D + Y++T + W+ + E L L S+ E + ++ +
Sbjct: 802 V-QAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL--SVTDYEIMEQRLGE 858
Query: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA----LLSRRNALHERAMRRRA 567
+ S+ +E+ + L +T + + + A +++ + + + R L + +
Sbjct: 859 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 918
Query: 568 QLADSFH-LQQFFRDSDELKSWVNEKMKTATDE--AYKDPSNLQGKVQKHQAFEAELSAN 624
+L + + L++ LK W+ E +E A D L+ ++++ + +++
Sbjct: 919 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 978
Query: 625 QSRIDALEKAGQKLIDVNHYAKDEVAARMN----EVISLWKKLLEATELKGIKLREANQQ 680
Q ++++ + GQK + + A+ E A+R+ E+ + W + + + L+ ++
Sbjct: 979 QPSLNSVNEGGQK---IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1035
Query: 681 Q-QFNRNVEDIELWLYEVEG--------HLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+++ ++ W+ + E + D+ K + ++ +++ EA V
Sbjct: 1036 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1095
Query: 732 DRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL-QQLF 790
+ ++ + QA E +KK+ E L Y+ L + + + L + +L
Sbjct: 1096 ESVNSVIAQAPPVAQ------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELL 1149
Query: 791 RDVEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
+E W+ E E + + N + +L + L + +I+ + Q
Sbjct: 1150 SYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT--- 1206
Query: 850 MVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREK 909
+ +G E + +L N +W L +A +R++ LE S+Q+ Q + ++ ++E
Sbjct: 1207 -LTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ---ETEKSLHLIQES 1262
Query: 910 EPIVGS--TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
+ Y D+ A + ++ + + SDL+++ S++ +++ Q +
Sbjct: 1263 LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG----------KE 1312
Query: 968 GKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQGFVPAAYVKKLDP 1026
+ VL+ D +K ++V+MK N + K+ +++ + +PA K ++
Sbjct: 1313 AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1372
Query: 1027 AQSASR----ENLLEEQGSIALRQEQIDN------QTRITKEAGSVSLRMKQVEELYHSL 1076
S+ NL + + E + Q + T+ + R+ ++ Y+ L
Sbjct: 1373 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1432
Query: 1077 LELGEKRKGMLEKSCKKFMLFR-EANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDD 1135
+RK LEK K R E N L +W+ + LT VE + D
Sbjct: 1433 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA------VEGMPSNLDS 1486
Query: 1136 -------FQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
QK+++ + LK I +V E L++ ++ + ET
Sbjct: 1487 EVAWGKATQKEIEKQKVHLKSITEVGEALKT------------------VLGKKET---- 1524
Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEE-RSQLLGSAHEVQRFHRDADETKE 1247
+ + LN W ++ AEE + LL ++ F ++ D +
Sbjct: 1525 --------------LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 1570
Query: 1248 WIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGD---KVNSLGETAERLIQSHP 1304
WI + + L D + + Q+K + +R A L D KV+S + A L+ +
Sbjct: 1571 WIIQADTLL-------DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG 1623
Query: 1305 ESAEDLQE-KCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
+ L E + +ELN ++++ R KA + +L++F SD + L+ +
Sbjct: 1624 DHCRKLVEPQISELNHRFAAISHRIKTGKASI-PLKELEQFNSDIQKLLEPLEA------ 1676
Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GHYASPEIKQKLD 1421
E+ + V E + E GT + Q G L EIK K
Sbjct: 1677 --EIQQGVNLKEEDFNKDMNEDNE-----GTVKELLQRGDNLQQRITDERKREEIKIKQQ 1729
Query: 1422 ILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVE 1481
+L + L+ QRR L++ H+ W + +D LD +E
Sbjct: 1730 LLQTKHNALKDLRSQRRKKA-----LEISHQ-------WYQYKR---QADDLLKCLDDIE 1774
Query: 1482 ALI---------KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDR 1532
+ +K ++ D+ + ++E++ A++ A+ L G A + + ++ R
Sbjct: 1775 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDG--AAMAVEPTQIQLSKR 1832
Query: 1533 WRRLKAQMIE-KRSKLGESQTLQQFSRDV--DEIEAWIS--------------------E 1569
WR ++++ + +R + T+++ + V +++ IS E
Sbjct: 1833 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 1892
Query: 1570 KLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAG 1629
+L A D KD L + + + + L ++ RI +I + + A
Sbjct: 1893 QLLNAPDLCAKD-----FEDLFKQEESLKNIKDSLQQSSGRI-DIIHSKKTAALQSATPV 1946
Query: 1630 SEDAVKARLAALADQWQFLVQKSAEKSQKL-KEANKQQNFNTGIKDFDFWLSEVEALLAS 1688
++ L+ L QW+ + + ++ + + K + F+ IK F+ WL+E E L
Sbjct: 1947 ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK 2006
Query: 1689 EDYGKDL--ASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRD 1745
++ A LK+ L+ I + ++ LN+ + ++ SS D S +++K
Sbjct: 2007 TQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2063
Query: 1746 TINGRFQKIKSMAASRRAKLNESHR-LHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTG 1803
++N R+Q++ + R+ +L E L +F RD+++ W++E + + G++
Sbjct: 2064 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE--- 2120
Query: 1804 VQNLRKKHKRLEAELAAHEPAIQGVL----DTGKKLSDDNTIGKEE---IQQRLAQFVEH 1856
Q L++K ++++ L P QG+L +TG + I EE ++ +L Q
Sbjct: 2121 -QQLKEKLEQVKL-LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2178
Query: 1857 W-KELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLK 1915
W K + L +G+ + + Q +E+ E +N + ++ +
Sbjct: 2179 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG 2238
Query: 1916 KHEAFETDFTVHKDR--VNDVCTNGQDLIKKNNHHE------ENISSKMKGLNGKVSDLE 1967
+ ET+ V + V ++ + GQ L K+ + E++SS+ K +N + +L
Sbjct: 2239 PFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELR 2298
Query: 1968 ------------------------------KAAAQRKAKLD-----ENSAFLQFNWKADV 1992
K A K ++ E A FN
Sbjct: 2299 AKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTE 2358
Query: 1993 VESWIGEKENSLKTDDYG-RDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2051
+ W+ + +K+ DL + ++ KQ+ A +Q +Q L++ + AA
Sbjct: 2359 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK---ATMQDLEQRR----PQLEELITAA 2411
Query: 2052 KHVQSKA--------IEARHASLMKRWSQLLANSAARKKKLLE----AQSHFRKVEDLFL 2099
+++++K I R + +W ++ + R+++L E + E+
Sbjct: 2412 QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 2471
Query: 2100 TFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELD 2159
+ + SW E D ++ + E K L + +++++ A N LA
Sbjct: 2472 VLGQARAKLESWKEGPYT--VDAIQ-KKITETKQLAKDLRQWQTNVDVA----NDLAL-- 2522
Query: 2160 RQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHA 2219
+ ++ + E + +WR++ K + ERE L EE +L Q+F
Sbjct: 2523 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL-------EETHRLLQQFPLDL 2575
Query: 2220 NAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKH--QEIRAMRSQLKKIEDLGAAM 2277
F W+ E T T +AT+++ ++ + ++ +K+ +DL +
Sbjct: 2576 EKFLAWLTEAET-------------TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2622
Query: 2278 E 2278
E
Sbjct: 2623 E 2623
Score = 116 bits (291), Expect = 2e-25
Identities = 398/2188 (18%), Positives = 823/2188 (37%), Gaps = 388/2188 (17%)
Query: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINAD-ELASDVAGAEALLDRHQEHKGEIDAHED 415
+ L R+ ++ SW+ + + A E+++DV + H+ + ++ AH+
Sbjct: 212 MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQG 271
Query: 416 SFKSADESGQALLAAGHYASDE---VREKLTVLSEERAAL-LELWELRRQQYEQCMDLQL 471
+ + G L+ G + DE V+E++ +L+ L + E + + MDLQ
Sbjct: 272 RVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ- 330
Query: 472 FYRDTEQVDNWMSKQEAF---LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528
+ +++++W++K E + E LG L+ ++ +++H+ ++ L ++ ++ +L
Sbjct: 331 -NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTH 389
Query: 529 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHL--QQFFRDSDELK 586
+ +++ + +L R A R R L L Q+ +
Sbjct: 390 MVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 449
Query: 587 SWVNEKMKTATD---EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNH 643
+W++EK +KD + + +QK +A+L EK Q
Sbjct: 450 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADL----------EKKKQS------ 493
Query: 644 YAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLAS 703
M ++ SL + LL + K + + E WL
Sbjct: 494 ---------MGKLYSLKQDLLSTLKNKSV--------------TQKTEAWL--------- 521
Query: 704 DDYGKDLTN-VQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEAL 762
D++ + N VQ L+K A + V Q + T+ + +++ L
Sbjct: 522 DNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET---------VTTVTTREQIL 572
Query: 763 V--ARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG--KDLIG 818
V A+ E P ++Q DS ++L D+ + +WI E + S +
Sbjct: 573 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGN 632
Query: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE---GHFAAEDVKAKLHELNQKWEAL 875
+L +K A++ E A +++ ++ A+VE+ A+ +K +LN +W
Sbjct: 633 FSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEF 692
Query: 876 KAKASQRRQDLEDSL-------QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEAL 928
S+R LE Q QQ AE+W++ +P S + + ++
Sbjct: 693 CQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI-QPTTPS-----EPTAIKSQ 746
Query: 929 LKKHEALMSDLSAYGSSIQALREQAQSCRQQ-VAPTDDETGKELVLALYDYQEKSPREVT 987
LK + ++ LS I+ L+ Q+ + +++ P + +A ++ ++ +V
Sbjct: 747 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDAD---FVAFTNHFKQVFSDVQ 803
Query: 988 MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQ-GSIALRQ 1046
++ ++ T+ ++ ++ ++ + +V + K P S + ++E++ G + Q
Sbjct: 804 AREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQ 863
Query: 1047 EQIDNQT-----------RITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
+ Q ++K+A S R Q E + + +K L + C+K
Sbjct: 864 SSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE--FEEIEGRWKKLSSQLVEHCQK-- 919
Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAE 1155
L + N+L++ N ++ L+K + LK L D + +
Sbjct: 920 LEEQMNKLRKIQNH----------------IQTLKKWMAEVDVFLKEEWPALGDSEILKK 963
Query: 1156 DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERW 1215
L+ L+ ++Q +Q + + + A P ++RL +KELN +W
Sbjct: 964 QLKQCRLLVSDIQTIQPS-LNSVNEGGQKIKNEAEPEFASRLETE-------LKELNTQW 1015
Query: 1216 RSL-QQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA-----SVQ 1269
+ QQ+ + L G + +D E EW+ + + ++ + +V+
Sbjct: 1016 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1075
Query: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAED-------------------L 1310
++R E ++ A KV L E+ +I P A++ L
Sbjct: 1076 EMKRAKEEAQQKEA----KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL 1131
Query: 1311 QEKCTELNQAWS----------SLGKRADQRKAKL-------GDSHDLQRFLSDFRDLMS 1353
KC L + W+ K ++ + KL G + ++ L +LM
Sbjct: 1132 NGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMR 1191
Query: 1354 WI----NGIRGLVSS----------------------DELAKDVTGAEALLERH------ 1381
N IR L + EL ++ + LLE+
Sbjct: 1192 HSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE 1251
Query: 1382 --------QEHRTEIDARAGTF-----------QAFEQFGQQLLAHGHYASPEIKQKLDI 1422
QE T ID + + Q ++ L +H + E+K+
Sbjct: 1252 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSH-EISLEEMKKHNQG 1310
Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDC--EQA--ENWMAAREAFLNT---EDKGD 1475
+ + L + V ++ + D ++ +LF + EQ E+ M E ++ E K
Sbjct: 1311 KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSV 1370
Query: 1476 SLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG-DISSRRNEVLDRWR 1534
+ V++ + + K+++ + ++ + Q++ ++ R + +
Sbjct: 1371 EQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 1430
Query: 1535 RLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
L A++ E++ +L + L ++ ++++ + W++ T + + + S L S+
Sbjct: 1431 ELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA---TDMELTKRSAVEGMPSNLDSE 1487
Query: 1594 HQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSA 1653
+A + E+ ++ + ++G +L + E V+ +L+ L W + ++
Sbjct: 1488 VAWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAE 1545
Query: 1654 EKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI 1712
E L E K + F+ + W+ + + LL E K ++LK+ L+A++
Sbjct: 1546 EWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-DESEKKKPQQKEDVLKR---LKAEL 1601
Query: 1713 SAHEDRLKDLNSQADSLMTSSAFDTSQ-VKDKRDTINGRFQKIKSMAASRRAKLNESHRL 1771
+ ++ QA +LM + + V+ + +N RF I + +A + L
Sbjct: 1602 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-PLKEL 1660
Query: 1772 HQFFRD----MDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
QF D ++ E+ I++ L ED+ +D+ +E ++
Sbjct: 1661 EQFNSDIQKLLEPLEAEIQQGVNLK-EEDFNKDMN----------------EDNEGTVKE 1703
Query: 1828 VLDTG----KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQR-LEESLEYQQFVA 1882
+L G ++++D+ + +I+Q+L Q +H LK L + R ++ LE S ++ Q+
Sbjct: 1704 LLQRGDNLQQRITDERKREEIKIKQQLLQ-TKH-NALKDLRSQRRKKALEISHQWYQYKR 1761
Query: 1883 NVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLI 1942
++ L +D LA++ + + E D + K + + +
Sbjct: 1762 QADD---------LLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK---------EEL 1803
Query: 1943 KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWKADVVESWIGEKE 2001
E +S +G +E Q + E S F QF + E+
Sbjct: 1804 NAVRRQAEGLSE-----DGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREET 1858
Query: 2002 NSLKTDDYGRDLSSV------------QTLLTKQETFDAG-------LQAFQQEGIANIT 2042
+ T+D ++S V Q LL ++ +A F+QE ++
Sbjct: 1859 MMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE--ESLK 1916
Query: 2043 ALKDQLLAAKH----VQSK-------AIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
+KD L + + SK A L + SQL K + Q F
Sbjct: 1917 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 1976
Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA---LREAHDAF------- 2141
+ + + F FN W AE+ L + E K L+E D
Sbjct: 1977 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2036
Query: 2142 RSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKE 2201
R+ ++ + Q ++ D I ++ S W Q++ K+ L
Sbjct: 2037 RTLNATGEEIIQQSSKTDASILQEKLGSLNLRW-------------QEVCKQ----LSDR 2079
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVE--ESGTLESQLEATKRKHQE 2259
++R EE + EF + N F W++E S +E + L+ +LE K +E
Sbjct: 2080 KKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASIPLEPGKEQQLKEKLEQVKLLVEE 2136
Query: 2260 IRAMRSQLKKIEDLGAAM--------EEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQH 2311
+ + LK++ + G + EE L+NK + + QW ++ + Q
Sbjct: 2137 LPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL-----QWIKVSRALPEKQG 2191
Query: 2312 NLEQQIQARNTTGVTEEALKEFSMMFKH 2339
+E QI+ G E+ L++ H
Sbjct: 2192 EIEAQIK---DLGQLEKKLEDLEEQLNH 2216
Score = 109 bits (272), Expect = 4e-23
Identities = 195/995 (19%), Positives = 413/995 (41%), Gaps = 111/995 (11%)
Query: 13 EDIQERRQQVLDRYHRFKELSTLRRQK-LEDSYRFQFFQRDAEELEKWIQE-KLQIASDE 70
E+I+ ++Q + +++ K+L + RR+K LE S+++ ++R A++L K + + + ++AS
Sbjct: 1722 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1781
Query: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS-----ETIRTRLM 125
+D ++ ++ Q + E+ A L E G M E I ++
Sbjct: 1782 EPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFA 1841
Query: 126 ELHRQWELLLEKMREKGIKLLQAQKLVQ-------YLRECEDVMDWINDKEAIVTSEEL- 177
+ R + +RE+ + ++ ++ YL E V + + E ++ + +L
Sbjct: 1842 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 1901
Query: 178 GQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAA 236
+D E + ++ + + + R++ ++ +Q P E + ++ +++
Sbjct: 1902 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ 1961
Query: 237 WQRLKGLALQRQGKLFGAAEV-QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLR 295
W+++ + RQG+ + E +RF+ D+ W+ E EQ + + +
Sbjct: 1962 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2021
Query: 296 KHEGLERDLAALEDKVKALCAEADR-LQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354
E L+ + + V+ L A + +QQS A+ +Q K L W+++ ++R
Sbjct: 2022 LKE-LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2080
Query: 355 ARLNDSYRLQRFLADF-RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHK---GEI 410
RL + + L++F RDL +V ++ N + + + L ++ ++ K E+
Sbjct: 2081 KRLEEQ---KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 2137
Query: 411 DAHEDSFKSADESGQALLAAGHYA---SDEVREKLTVLS---------------EERAAL 452
+ K +E+G +L + + D++ KL + E A +
Sbjct: 2138 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2197
Query: 453 LELWELRRQ---QYEQCMDLQLF---YRDTEQVDNWMSKQEAFLLNED---LGDSLDSVE 503
+L +L ++ EQ L L+ R+ ++ N +++ F + E + VE
Sbjct: 2198 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2257
Query: 504 ALLKKHEDFEKSLSAQEEKITALDEFAT------KLIQNNHYAMEDVA----------TR 547
+L K + K A + L++ ++ +L+Q D+A T+
Sbjct: 2258 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2317
Query: 548 RDALLSRRNALHERAMRRRAQLADSFHLQ-----QFFRDSDELKSWVN--EKMKTATDEA 600
L+++ E A+ + ++ S L+ F R EL W++ +++ +
Sbjct: 2318 TVTLVTQPVVTKETAI-SKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2376
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID--VNHYAKDEVAARMNEVIS 658
D ++ + K +A +L + +++ L A Q L + N A+ + R+ + +
Sbjct: 2377 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2436
Query: 659 LWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVE--------GHLASDDYGKDL 710
W ++ E + N++QQ N ++D WL E + + +
Sbjct: 2437 QWDEVQEHLQ---------NRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2487
Query: 711 TNVQNLQKK---HALLEADVAAHQDRID-GITIQARQFQDAGHFDAENIKKKQEALVARY 766
V +QKK L D+ Q +D + + +D D + E + A +
Sbjct: 2488 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW 2547
Query: 767 EALKEPMVARKQKLADSLRLQQLF-RDVEDEETWIREKEPIA----ASTNRGK---DLIG 818
++ + + R+ L ++ RL Q F D+E W+ E E A +T + + D G
Sbjct: 2548 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG 2607
Query: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE--EGHFAAEDVKAKLHELNQKWEALK 876
V+ L+K+ Q LQ EI H + + ++ EG A ++ +L +N KW L+
Sbjct: 2608 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR 2667
Query: 877 AKASQRRQDLE-DSLQAQQYFADANEAESWMREKE 910
K+ R LE S Q ++ E W++ K+
Sbjct: 2668 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 2702
Score = 100 bits (248), Expect = 2e-20
Identities = 181/943 (19%), Positives = 381/943 (40%), Gaps = 133/943 (14%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD--ENYKDPTNLQGKLQKHQA 87
K+LS +++ E FQRD E W++E IAS E K+ L+ KL++ +
Sbjct: 2074 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ-QLKEKLEQVKL 2132
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASET---IRTRLMELHRQWELLLEKMREKGIK 144
E+ G + +L+ETG ++ + E + +L + + QW + + EK +
Sbjct: 2133 LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE 2192
Query: 145 L-LQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
+ Q + L Q ++ ED+ E+L L + ++ + E +
Sbjct: 2193 IEAQIKDLGQLEKKLEDL------------EEQLNHLLLWLSPIRNQLEIY--------- 2231
Query: 204 RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
N+ NQ +QE E ++ KQ +V + + L ++ Q R
Sbjct: 2232 --NQPNQEGPFDVQET---EIAVQAKQPDVEEILSKGQHLYKEKPA-------TQPVKRK 2279
Query: 264 VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
++ D + +V LL++ + DLA + A + L
Sbjct: 2280 LE----------------DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL-- 2321
Query: 324 SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFR----DLTSWVTE 379
TQ V +E I+ E +L E A LADF +LT W++
Sbjct: 2322 -----VTQPVVTKETAISKLEMPSSLMLEVPA-----------LADFNRAWTELTDWLSL 2365
Query: 380 MKALINADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASD 436
+ +I + + D+ ++ + + +++ + + Q L + A
Sbjct: 2366 LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART 2425
Query: 437 EVREKLTVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLLNEDL 495
+ +++ + + + E + RRQQ + + D + E+ + + + A L +
Sbjct: 2426 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE 2485
Query: 496 GD-SLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSR 554
G ++D+++ + + + K L + + ++ A KL+++ Y+ +D TR+ +++
Sbjct: 2486 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD--YSADD--TRKVHMITE 2541
Query: 555 R-----NALHERAMRRRAQLADSFHL-QQFFRDSDELKSWVNEKMKTAT--------DEA 600
++H+R R A L ++ L QQF D ++ +W+ E TA +
Sbjct: 2542 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 2601
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA--RMNEVIS 658
+D ++ +++ Q + E+ A+ L++ QK++ + D V R++ +
Sbjct: 2602 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2661
Query: 659 LWKKLLEAT-ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNL 716
W +L + + ++ ++Q ++ + +++++ +WL + L+ G D VQ
Sbjct: 2662 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2721
Query: 717 QKKHALLEADVAAHQDRIDGITIQARQFQDAGHFD-----------------AENI---- 755
H + ++ + I R F + A+N+
Sbjct: 2722 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2781
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGK 814
+K+ E + +E L ++K+ ++L RLQ+L ++ + +R+ E I S
Sbjct: 2782 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 2841
Query: 815 DLI--GVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKW 872
DL+ +Q+ L+K +AL+ EIA + + V + G + + L +LN +W
Sbjct: 2842 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 2901
Query: 873 EALKAKASQRRQDLEDSLQ----AQQYFADANEAESWMREKEP 911
+ L+ R + L ++ + A Q+F + W R P
Sbjct: 2902 KLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISP 2944
>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
Length = 3681
Score = 186 bits (473), Expect = 2e-46
Identities = 439/2327 (18%), Positives = 908/2327 (39%), Gaps = 344/2327 (14%)
Query: 19 RQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE---KLQIASDENYKDP 75
+Q D R KEL T+ D+ +Q + W+Q+ KL I + D
Sbjct: 915 KQVFSDVQAREKELQTIF-----DTLPPMRYQETMSAIRTWVQQSETKLSIPQ-LSVTDY 968
Query: 76 TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFA-SETIRTRLMELHRQWELL 134
++ +L + QA ++ +Q + L T M + S ++ E+ +W+ L
Sbjct: 969 EIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKL 1028
Query: 135 LEKMREKGIKLL-QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
++ E KL Q KL + + + W+ + + + E L E+L+K+ ++
Sbjct: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEE--WPALGDSEILKKQLKQ 1086
Query: 194 FQ---TDMAAHEERVNEVNQFAAKLIQEQHPE-EELIKTKQDEVNAAWQRLKGLALQRQG 249
+ +D+ + +N VN+ K+ E PE ++T+ E+N W + R+
Sbjct: 1087 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKE 1146
Query: 250 KLFGAAE-VQRFNRDVDETISWIKEKEQLMASDDFG-RDLASVQALLRKHEGLERDLAAL 307
L G E +D+ E W+ + E+ DF + +Q + + + + +
Sbjct: 1147 ALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQK 1206
Query: 308 EDKVKALCAEADR-LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR-LQR 365
E KVK L + + Q+ P++ ++ + E L TN++ + T RLN + L+
Sbjct: 1207 EAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCT-------RLNGKCKTLEE 1259
Query: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
A + +L S++ + +N E+ + E + +E +D+ E+ + ++++
Sbjct: 1260 VWACWHELLSYLEKANKWLN--EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1317
Query: 426 AL------LAAGHYASDEVREKLTV-------LSEE---RAALLELWELRRQQYEQCM-- 467
+ L G + + E+L L EE R LLE Q+ E+ +
Sbjct: 1318 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1377
Query: 468 --------DLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQ 519
D QL ++VD QEA + DL S+E + K ++ E A
Sbjct: 1378 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKE----AA 1433
Query: 520 EEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFF 579
+ ++ +D KL +DV+ + L ++ A E+ ++ + D +
Sbjct: 1434 QRVLSQIDVAQKKL--------QDVSMK--FRLFQKPANFEQRLQESKMILDEVKMHLPA 1483
Query: 580 RDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLI 639
++ ++ V + YK LS +S ++ + K G++++
Sbjct: 1484 LETKSVEQEVVQSQLNHCVNLYKS-----------------LSEVKSEVEMVIKTGRQIV 1526
Query: 640 DVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ--------QQFNRNVEDIE 691
+ E ++E ++ K L EL G K+ E QQ ++ + + +
Sbjct: 1527 QKK---QTENPKELDERVTALK--LHYNEL-GAKVTERKQQLEKCLKLSRKMRKEMNVLT 1580
Query: 692 LWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA---AHQDRIDGITIQARQFQDAG 748
WL + +LT ++ + L+++VA A Q I+ + + + G
Sbjct: 1581 EWLAATD---------MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1631
Query: 749 HFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL--------QQLFRDVEDEETWI 800
+ KK+ + + L +A + + L L + ++V+ WI
Sbjct: 1632 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 1691
Query: 801 REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT-QKGNAMVEEGHFAAE 859
+ + + + + K +++LK+ L+AE+ P++ + Q N M G +
Sbjct: 1692 IQADTLLDESEKKKPQ-QKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1747
Query: 860 DVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
V+ ++ ELN ++ A+ + + + + +Q+ +D + EP+ G
Sbjct: 1748 LVEPQISELNHRFAAISHRIKTGKASIPLK-ELEQFNSDIQKL------LEPLEAEIQQG 1800
Query: 920 ---KDEDSAEALLKKHEALMSDLSAYGSSIQAL-----REQAQSCRQQVAPTDDETGKEL 971
K+ED + + + +E + +L G ++Q + + +QQ+ T K+L
Sbjct: 1801 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1860
Query: 972 VLALYDYQEKSPREVT-------MKKGDILTLLNSTNK---------DWWKVEVNDRQGF 1015
+ K E++ + D+L L+ K D K++ DR+
Sbjct: 1861 ----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRE-- 1914
Query: 1016 VPAAYVKKLDPAQSASR--ENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELY 1073
KK + + R E L E+ ++A+ QI +S R +++E
Sbjct: 1915 ----LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----------LSKRWREIES-- 1957
Query: 1074 HSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAALTSEEVGADLEQV-EVLQK 1131
KF FR N Q + E+ + +E++ ++ V
Sbjct: 1958 -------------------KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT 1998
Query: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191
+ + L E L + A+D E E ++ ++ D SK +
Sbjct: 1999 EITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAA 2058
Query: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIE 1250
+SA V V ++ +L+ +W + ++ ++R S + +RFH D +W+
Sbjct: 2059 LQSAT-PVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2117
Query: 1251 EKNQALNT----DNYGHDLASVQALQRKHEGFERDLA-ALGDK---VNSLGETAERLIQ- 1301
E Q L +N+ H K++ + ++L +G + V +L T E +IQ
Sbjct: 2118 EAEQFLRKTQIPENWEH---------AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2168
Query: 1302 SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD-LQRFLSDFRDLMSWINGIRG 1360
S A LQEK LN W + K+ RK +L + + L F D + + W+
Sbjct: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2228
Query: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKL 1420
+ S + LE+ + E+ R G + + G +L ++P ++
Sbjct: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV----SAPISPEEQ 2284
Query: 1421 DILDQERADLEKAWVQ-RRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
D L+ + W++ R + ++ E++ +D Q E
Sbjct: 2285 DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE--------------------- 2323
Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
KK ED ++ +N + L +QL +I ++ N+
Sbjct: 2324 -----KKLEDLEEQLN---HLLLWLSPIRNQL---------EIYNQPNQ----------- 2355
Query: 1540 MIEKRSKLGESQTLQQFSR-DVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
E + E++ Q + DV+EI +S+ ++ P +L L S+ +
Sbjct: 2356 --EGPFDVQETEIAVQAKQPDVEEI---LSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 2410
Query: 1599 AFEAELHANA-DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQ 1657
EL A D G+ +G S + K + + K S
Sbjct: 2411 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTK----------ETAISKLEMPSS 2460
Query: 1658 KLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLEADISAHE 1716
+ E +FN + WLS ++ ++ S+ DL +N ++ K + D+
Sbjct: 2461 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2520
Query: 1717 DRLKDLNSQADSLM--TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR-LHQ 1773
+L++L + A +L TS+ + + D+ + I ++ +++ +RR +LNE + Q
Sbjct: 2521 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2580
Query: 1774 FFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTG 1832
+ ++ E + + + + S G + +Q + K+L +L + + D
Sbjct: 2581 WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA 2640
Query: 1833 KKLSDDNTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAW 1890
KL D + + + + W+ + + + R LEE+ QQF ++E+ AW
Sbjct: 2641 LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW 2700
Query: 1891 INEKMTLV-------ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIK 1943
+ E T E + ++ L+K+ + + + H D +++ N Q +++
Sbjct: 2701 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2760
Query: 1944 KNNHHEENI--SSKMKGLNGKVSDLEKAAAQRKAKLDENS-AFLQFNWKADVVESWIGEK 2000
++ + ++ +N K S+L K + ++ L+ +S + + + + W+ K
Sbjct: 2761 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2820
Query: 2001 ENSLKTD-DYGRDLSSVQT-----------LLTKQETFDAGLQAFQ-------QEGIANI 2041
++ L G D +VQ L TK+ + L+ + EG+ +
Sbjct: 2821 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 2880
Query: 2042 TALKDQLLAAKHVQS--KAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKVED 2096
+L + Q+ + + + + W +L +SA ++K+ LE ++ D
Sbjct: 2881 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 2940
Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA 2156
++A ++ + L D ++ + LE++KALR ++ + + + +
Sbjct: 2941 ELDLKLRQAEVIKGSWQPVGDLLIDSLQ-DHLEKVKALR-------GEIAPLKENVSHVN 2992
Query: 2157 ELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQR 2203
+L RQ+ + + +PY T+E L W+ LQ +++R +L + R
Sbjct: 2993 DLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHR 3039
Score = 179 bits (455), Expect = 2e-44
Identities = 457/2309 (19%), Positives = 880/2309 (38%), Gaps = 406/2309 (17%)
Query: 142 GIKLLQAQ-KLVQYLRECEDVMDWINDKEAIVTSE-ELGQDLEHVEVLQKKFEEFQTDMA 199
G L++++ L +Y E+V+ W+ E + ++ E+ D+E V+ E + D+
Sbjct: 327 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 386
Query: 200 AHEERVNEVNQFAAKLI---QEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAE 256
AH+ RV + Q +KLI + EE ++ + + +N+ W+ L+ ++++Q L
Sbjct: 387 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVL- 445
Query: 257 VQRFNRDVDETISWI---KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
+ N+ + E W+ +E+ + M + G DL ++ +++H+ L+ DL + +V +
Sbjct: 446 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505
Query: 314 L---CAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLND-SYRLQRFLAD 369
L D H +A + Q+K L W I +R L D + QR +
Sbjct: 506 LTHMVVVVDESSGDHATAALEEQLK--VLGDRWANICRWTEDRWVLLQDILLKWQRLTEE 563
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
++W++E + +N H FK +E +L
Sbjct: 564 QCLFSAWLSEKEDAVN-------------------------KIHTTGFKDQNEMLSSL-- 596
Query: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
+KL VL + E ++Q + L+ T + + K EA+
Sbjct: 597 ----------QKLAVLKAD-------LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAW 639
Query: 490 LLN-EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
L N D+L V+ L K ++++ + +T T + V TR
Sbjct: 640 LDNFARCWDNL--VQKLEKSTAQISQAVTTTQPSLTQTTVMET---------VTTVTTRE 688
Query: 549 DALL--SRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK---MKTATDEAYKD 603
L+ ++ ++R DS ++ D EL SW+ +++ ++
Sbjct: 689 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 748
Query: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID--VNH--------YAKDEVAARM 653
N +K A E E + ++ ++ Q L++ VN A +++ +R
Sbjct: 749 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 808
Query: 654 NEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNV 713
E L + L E + + NQ QQ + E WL +++ S+ T +
Sbjct: 809 IEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWL-KIQPTTPSEP-----TAI 862
Query: 714 QNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGH----FDAENIKKKQEALVARYEAL 769
++ K ++ Q +I+ + IQ+ ++ G DA+ + A ++ +
Sbjct: 863 KSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFV-----AFTNHFKQV 917
Query: 770 KEPMVARKQKLA---DSLRLQQLFRDVEDEETWIREKE-PIAASTNRGKDLIGVQNLLKK 825
+ AR+++L D+L + + TW+++ E ++ D ++ L +
Sbjct: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
Query: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEG-HFAAEDVKAKLHELNQKWEALKAKASQRRQ 884
QALQ+ + + + ++ M ++ + +++ E+ +W+ L ++ + Q
Sbjct: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037
Query: 885 DLEDSLQAQQYFAD--------ANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALM 936
LE+ + + + E + +++E+ P +G ++ K + LK+ L+
Sbjct: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ------LKQCRLLV 1091
Query: 937 SDLSAYGSSIQALREQAQSCRQQVAP---TDDETGKELVLALYDY--QEKSPREVTMKKG 991
SD+ S+ ++ E Q + + P + ET + + +D+ Q+ R+ +K G
Sbjct: 1092 SDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGG 1151
Query: 992 DILTLLNSTNKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSA------SRENLLEEQG 1040
L S KD W + + Y K D Q A ++E +++
Sbjct: 1152 --LEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-KTPDELQKAVEEMKRAKEEAQQKEA 1208
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEEL---YHSL-LELGEKRKGMLEKSCKKFML 1096
+ L E +++ +L+ K++E L Y L L K K + E L
Sbjct: 1209 KVKLLTESVNSVIAQAPPVAQEALK-KELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1267
Query: 1097 FREANELQQWINEKEAAL-TSEEVGADLEQV-EVLQKKFDDFQKDLKANESRLKDINKVA 1154
+ +W+NE E L T+E + E++ EVL D + ++ +E I +A
Sbjct: 1268 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL----DSLENLMRHSEDNPNQIRILA 1323
Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
+ L G+M E L+ + TFNS R
Sbjct: 1324 QTLTDGGVMDE-------------------------------LINEELETFNS------R 1346
Query: 1215 WRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRK 1274
WR L + A R +LL ++ + A ET++ S+ +Q
Sbjct: 1347 WRELHEEAVRRQKLL------EQSIQSAQETEK-------------------SLHLIQES 1381
Query: 1275 HEGFERDLAA-LGDKVNSLGETAE-RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRK 1332
++ LAA + DKV++ E + IQS S E E+ + NQ GK A QR
Sbjct: 1382 LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQ-----GKEAAQRV 1436
Query: 1333 AKLGD--SHDLQRFLSDFRDLMSWINGIRGLVSS----DELAKDVTGAEALLERHQEHRT 1386
D LQ FR N + L S DE+ + E + ++
Sbjct: 1437 LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQS 1496
Query: 1387 EIDARAGTFQAFEQF----------GQQLLAHGHYASP-EIKQKLDILDQERADLEKAWV 1435
+++ +++ + G+Q++ +P E+ +++ L +L
Sbjct: 1497 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVT 1556
Query: 1436 QRRMMLDQCLEL-QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
+R+ L++CL+L + ++ W+AA + L K +++ + + + + KA
Sbjct: 1557 ERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT---KRSAVEGMPSNLDSEVAWGKAT 1613
Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGE----- 1549
+ EK + + G K + + V D+ L + I S+ E
Sbjct: 1614 QKEIEK---QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLL 1670
Query: 1550 ---SQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHA 1606
+ ++ F ++VD I WI + T DES K K K + +AEL+
Sbjct: 1671 LEYQKHMETFDQNVDHITKWIIQ-ADTLLDESEK-------KKPQQKEDVLKRLKAELND 1722
Query: 1607 NADRIRGVIDM-GNSLIERGACAGSEDAVKARLAALADQWQFLVQ--KSAEKSQKLKEAN 1663
++ D N + RG V+ +++ L ++ + K+ + S LKE
Sbjct: 1723 IRPKVDSTRDQAANLMANRG--DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKEL- 1779
Query: 1664 KQQNFNTGIKDFDFWLSEVEA------LLASEDYGKDLASVNNLLKKHQLLEADISAHED 1717
+ FN+ I+ L +EA L ED+ KD+ N E
Sbjct: 1780 --EQFNSDIQKL---LEPLEAEIQQGVNLKEEDFNKDMNEDN----------------EG 1818
Query: 1718 RLKDLNSQADSLM--TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAK-LNESHRLHQF 1774
+K+L + D+L + ++K K+ + + +K + + RR K L SH+ +Q+
Sbjct: 1819 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1878
Query: 1775 FRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLR--KKHKRLEAELAAHEPAIQGVLDTG 1832
R DD LL +D + L + R +K K ++ EL + + V
Sbjct: 1879 KRQADD---------LLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1929
Query: 1833 KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWIN 1892
+ LS+D E Q Q + W+E++ A L + Q EE +
Sbjct: 1930 EGLSEDGAAMAVEPTQ--IQLSKRWREIESKFAQ-----FRRLNFAQIHTVREETMMVMT 1982
Query: 1893 EKMTLVASEDYGDTLAAI----QGLLKKHEAFETDFTVHKD-----RVNDVCTNGQDLIK 1943
E M L S L I Q LL+ + KD + + N +D ++
Sbjct: 1983 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2042
Query: 1944 KNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENS 2003
+++ + I SK K + L+ A + KL E + L F W EK N
Sbjct: 2043 QSSGRIDIIHSK------KTAALQSATPVERVKLQEALSQLDFQW----------EKVNK 2086
Query: 2004 LKTDDYGR-------------DLSSVQTLLTKQETFDAGLQAFQ--------------QE 2036
+ D GR D+ LT+ E F Q + Q+
Sbjct: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2146
Query: 2037 GIA-------NITALKDQLL-AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ 2088
GI + A ++++ + + ++ + SL RW ++ + RKK+L E
Sbjct: 2147 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ- 2205
Query: 2089 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA 2148
+++ F + + F W E A+ + P+ +++K E L
Sbjct: 2206 ------KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLR 2259
Query: 2149 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEE-------TWRNLQKIIKERELELQKE 2201
Q QL E + + S P + + LE W + + + E++ E++ +
Sbjct: 2260 QGILKQLNETGGPV----LVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQ 2315
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYL-------LDGSCMVEES--------GTL 2246
+ + +K ++ + N W+ R L +G V+E+ +
Sbjct: 2316 IKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDV 2375
Query: 2247 ESQLEATKRKHQEIRAMRSQLKKIEDLGA 2275
E L + ++E A + +K+EDL +
Sbjct: 2376 EEILSKGQHLYKEKPATQPVKRKLEDLSS 2404
Score = 157 bits (396), Expect = 2e-37
Identities = 438/2401 (18%), Positives = 922/2401 (38%), Gaps = 386/2401 (16%)
Query: 49 FQRDAEE---LEKWIQEKLQIASD---ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKL 102
+QR EE W+ EK + +KD + LQK +A+++ ++ KL
Sbjct: 557 WQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 616
Query: 103 DETGNLMISEGHFASETIRTR--LMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED 160
++S S T +T L R W+ L++K+ + ++ QA Q
Sbjct: 617 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 676
Query: 161 VMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQH 220
VM+ + VT+ E Q K QE+
Sbjct: 677 VMETVTT----VTTRE---------------------------------QILVKHAQEEL 699
Query: 221 PEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMAS 280
P K +Q V++ ++ R + D+ E SWI E ++ S
Sbjct: 700 PPPPPQKKRQITVDSEIRK-------------------RLDVDITELHSWITRSEAVLQS 740
Query: 281 DDFG--RDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ---SHPLSATQIQVK 335
+F R + L K +ER+ A K++ A L + + ++A I+
Sbjct: 741 PEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQA 800
Query: 336 REELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA-SDVA 394
E+L + W + L +ER L + F + L T + + S+
Sbjct: 801 SEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 860
Query: 395 GAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
++ L ++ + + + AL G + + + + +
Sbjct: 861 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSD 920
Query: 455 LWELRRQQYEQCMDL--QLFYRDT-EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
+ + R ++ + D + Y++T + W+ + E L L S+ E + ++ +
Sbjct: 921 V-QAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL--SVTDYEIMEQRLGE 977
Query: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA----LLSRRNALHERAMRRRA 567
+ S+ +E+ + L +T + + + A +++ + + + R L + +
Sbjct: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037
Query: 568 QLADSFH-LQQFFRDSDELKSWVNEKMKTATDE--AYKDPSNLQGKVQKHQAFEAELSAN 624
+L + + L++ LK W+ E +E A D L+ ++++ + +++
Sbjct: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1097
Query: 625 QSRIDALEKAGQKLIDVNHYAKDEVAARMN----EVISLWKKLLEATELKGIKLREANQQ 680
Q ++++ + GQK + + A+ E A+R+ E+ + W + + + L+ ++
Sbjct: 1098 QPSLNSVNEGGQK---IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1154
Query: 681 Q-QFNRNVEDIELWLYEVEG--------HLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+++ ++ W+ + E + D+ K + ++ +++ EA V
Sbjct: 1155 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1214
Query: 732 DRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL-QQLF 790
+ ++ + QA E +KK+ E L Y+ L + + + L + +L
Sbjct: 1215 ESVNSVIAQAPPVAQ------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELL 1268
Query: 791 RDVEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
+E W+ E E + + N + +L + L + +I+ + Q
Sbjct: 1269 SYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT--- 1325
Query: 850 MVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREK 909
+ +G E + +L N +W L +A +R++ LE S+Q+ Q + ++ ++E
Sbjct: 1326 -LTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ---ETEKSLHLIQES 1381
Query: 910 EPIVGS--TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
+ Y D+ A + ++ + + SDL+++ S++ +++ Q +
Sbjct: 1382 LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG----------KE 1431
Query: 968 GKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQGFVPAAYVKKLDP 1026
+ VL+ D +K ++V+MK N + K+ +++ + +PA K ++
Sbjct: 1432 AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1491
Query: 1027 AQSASR----ENLLEEQGSIALRQEQIDN------QTRITKEAGSVSLRMKQVEELYHSL 1076
S+ NL + + E + Q + T+ + R+ ++ Y+ L
Sbjct: 1492 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1551
Query: 1077 LELGEKRKGMLEKSCKKFMLFR-EANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDD 1135
+RK LEK K R E N L +W+ + LT VE + D
Sbjct: 1552 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA------VEGMPSNLDS 1605
Query: 1136 -------FQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
QK+++ + LK I +V E L++ ++ + ET
Sbjct: 1606 EVAWGKATQKEIEKQKVHLKSITEVGEALKT------------------VLGKKET---- 1643
Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEE-RSQLLGSAHEVQRFHRDADETKE 1247
+ + LN W ++ AEE + LL ++ F ++ D +
Sbjct: 1644 --------------LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 1689
Query: 1248 WIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGD---KVNSLGETAERLIQSHP 1304
WI + + L D + + Q+K + +R A L D KV+S + A L+ +
Sbjct: 1690 WIIQADTLL-------DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG 1742
Query: 1305 ESAEDLQE-KCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
+ L E + +ELN ++++ R KA + +L++F SD + L+ +
Sbjct: 1743 DHCRKLVEPQISELNHRFAAISHRIKTGKASI-PLKELEQFNSDIQKLLEPLEA------ 1795
Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GHYASPEIKQKLD 1421
E+ + V E + E GT + Q G L EIK K
Sbjct: 1796 --EIQQGVNLKEEDFNKDMNEDNE-----GTVKELLQRGDNLQQRITDERKREEIKIKQQ 1848
Query: 1422 ILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVE 1481
+L + L+ QRR L++ H+ W + +D LD +E
Sbjct: 1849 LLQTKHNALKDLRSQRRKKA-----LEISHQ-------WYQYKR---QADDLLKCLDDIE 1893
Query: 1482 ALI---------KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDR 1532
+ +K ++ D+ + ++E++ A++ A+ L G A + + ++ R
Sbjct: 1894 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDG--AAMAVEPTQIQLSKR 1951
Query: 1533 WRRLKAQMIE-KRSKLGESQTLQQFSRDV--DEIEAWIS--------------------E 1569
WR ++++ + +R + T+++ + V +++ IS E
Sbjct: 1952 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 2011
Query: 1570 KLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAG 1629
+L A D KD L + + + + L ++ RI +I + + A
Sbjct: 2012 QLLNAPDLCAKD-----FEDLFKQEESLKNIKDSLQQSSGRI-DIIHSKKTAALQSATPV 2065
Query: 1630 SEDAVKARLAALADQWQFLVQKSAEKSQKL-KEANKQQNFNTGIKDFDFWLSEVEALLAS 1688
++ L+ L QW+ + + ++ + + K + F+ IK F+ WL+E E L
Sbjct: 2066 ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK 2125
Query: 1689 EDYGKDL--ASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRD 1745
++ A LK+ L+ I + ++ LN+ + ++ SS D S +++K
Sbjct: 2126 TQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2182
Query: 1746 TINGRFQKIKSMAASRRAKLNESHR-LHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTG 1803
++N R+Q++ + R+ +L E L +F RD+++ W++E + + G++
Sbjct: 2183 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE--- 2239
Query: 1804 VQNLRKKHKRLEAELAAHEPAIQGVL----DTGKKLSDDNTIGKEE---IQQRLAQFVEH 1856
Q L++K ++++ L P QG+L +TG + I EE ++ +L Q
Sbjct: 2240 -QQLKEKLEQVKL-LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2297
Query: 1857 W-KELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLK 1915
W K + L +G+ + + Q +E+ E +N + ++ +
Sbjct: 2298 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG 2357
Query: 1916 KHEAFETDFTVHKDR--VNDVCTNGQDLIKKNNHHE------ENISSKMKGLNGKVSDLE 1967
+ ET+ V + V ++ + GQ L K+ + E++SS+ K +N + +L
Sbjct: 2358 PFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELR 2417
Query: 1968 ------------------------------KAAAQRKAKLD-----ENSAFLQFNWKADV 1992
K A K ++ E A FN
Sbjct: 2418 AKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTE 2477
Query: 1993 VESWIGEKENSLKTDDYG-RDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2051
+ W+ + +K+ DL + ++ KQ+ A +Q +Q L++ + AA
Sbjct: 2478 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK---ATMQDLEQRR----PQLEELITAA 2530
Query: 2052 KHVQSKA--------IEARHASLMKRWSQLLANSAARKKKLLE----AQSHFRKVEDLFL 2099
+++++K I R + +W ++ + R+++L E + E+
Sbjct: 2531 QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 2590
Query: 2100 TFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELD 2159
+ + SW E D ++ + E K L + +++++ A N LA
Sbjct: 2591 VLGQARAKLESWKEGPYT--VDAIQ-KKITETKQLAKDLRQWQTNVDVA----NDLAL-- 2641
Query: 2160 RQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHA 2219
+ ++ + E + +WR++ K + ERE L EE +L Q+F
Sbjct: 2642 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL-------EETHRLLQQFPLDL 2694
Query: 2220 NAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKH--QEIRAMRSQLKKIEDLGAAM 2277
F W+ E T T +AT+++ ++ + ++ +K+ +DL +
Sbjct: 2695 EKFLAWLTEAET-------------TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2741
Query: 2278 E 2278
E
Sbjct: 2742 E 2742
Score = 116 bits (291), Expect = 2e-25
Identities = 398/2188 (18%), Positives = 823/2188 (37%), Gaps = 388/2188 (17%)
Query: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINAD-ELASDVAGAEALLDRHQEHKGEIDAHED 415
+ L R+ ++ SW+ + + A E+++DV + H+ + ++ AH+
Sbjct: 331 MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQG 390
Query: 416 SFKSADESGQALLAAGHYASDE---VREKLTVLSEERAAL-LELWELRRQQYEQCMDLQL 471
+ + G L+ G + DE V+E++ +L+ L + E + + MDLQ
Sbjct: 391 RVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ- 449
Query: 472 FYRDTEQVDNWMSKQEAF---LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528
+ +++++W++K E + E LG L+ ++ +++H+ ++ L ++ ++ +L
Sbjct: 450 -NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTH 508
Query: 529 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHL--QQFFRDSDELK 586
+ +++ + +L R A R R L L Q+ +
Sbjct: 509 MVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568
Query: 587 SWVNEKMKTATD---EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNH 643
+W++EK +KD + + +QK +A+L EK Q
Sbjct: 569 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADL----------EKKKQS------ 612
Query: 644 YAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLAS 703
M ++ SL + LL + K + + E WL
Sbjct: 613 ---------MGKLYSLKQDLLSTLKNKSV--------------TQKTEAWL--------- 640
Query: 704 DDYGKDLTN-VQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEAL 762
D++ + N VQ L+K A + V Q + T+ + +++ L
Sbjct: 641 DNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET---------VTTVTTREQIL 691
Query: 763 V--ARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG--KDLIG 818
V A+ E P ++Q DS ++L D+ + +WI E + S +
Sbjct: 692 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGN 751
Query: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE---GHFAAEDVKAKLHELNQKWEAL 875
+L +K A++ E A +++ ++ A+VE+ A+ +K +LN +W
Sbjct: 752 FSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEF 811
Query: 876 KAKASQRRQDLEDSL-------QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEAL 928
S+R LE Q QQ AE+W++ +P S + + ++
Sbjct: 812 CQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI-QPTTPS-----EPTAIKSQ 865
Query: 929 LKKHEALMSDLSAYGSSIQALREQAQSCRQQ-VAPTDDETGKELVLALYDYQEKSPREVT 987
LK + ++ LS I+ L+ Q+ + +++ P + +A ++ ++ +V
Sbjct: 866 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDAD---FVAFTNHFKQVFSDVQ 922
Query: 988 MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQ-GSIALRQ 1046
++ ++ T+ ++ ++ ++ + +V + K P S + ++E++ G + Q
Sbjct: 923 AREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQ 982
Query: 1047 EQIDNQT-----------RITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
+ Q ++K+A S R Q E + + +K L + C+K
Sbjct: 983 SSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE--FEEIEGRWKKLSSQLVEHCQK-- 1038
Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAE 1155
L + N+L++ N ++ L+K + LK L D + +
Sbjct: 1039 LEEQMNKLRKIQNH----------------IQTLKKWMAEVDVFLKEEWPALGDSEILKK 1082
Query: 1156 DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERW 1215
L+ L+ ++Q +Q + + + A P ++RL +KELN +W
Sbjct: 1083 QLKQCRLLVSDIQTIQPS-LNSVNEGGQKIKNEAEPEFASRLETE-------LKELNTQW 1134
Query: 1216 RSL-QQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA-----SVQ 1269
+ QQ+ + L G + +D E EW+ + + ++ + +V+
Sbjct: 1135 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1194
Query: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAED-------------------L 1310
++R E ++ A KV L E+ +I P A++ L
Sbjct: 1195 EMKRAKEEAQQKEA----KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL 1250
Query: 1311 QEKCTELNQAWS----------SLGKRADQRKAKL-------GDSHDLQRFLSDFRDLMS 1353
KC L + W+ K ++ + KL G + ++ L +LM
Sbjct: 1251 NGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMR 1310
Query: 1354 WI----NGIRGLVSS----------------------DELAKDVTGAEALLERH------ 1381
N IR L + EL ++ + LLE+
Sbjct: 1311 HSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE 1370
Query: 1382 --------QEHRTEIDARAGTF-----------QAFEQFGQQLLAHGHYASPEIKQKLDI 1422
QE T ID + + Q ++ L +H + E+K+
Sbjct: 1371 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSH-EISLEEMKKHNQG 1429
Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDC--EQA--ENWMAAREAFLNT---EDKGD 1475
+ + L + V ++ + D ++ +LF + EQ E+ M E ++ E K
Sbjct: 1430 KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSV 1489
Query: 1476 SLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG-DISSRRNEVLDRWR 1534
+ V++ + + K+++ + ++ + Q++ ++ R + +
Sbjct: 1490 EQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 1549
Query: 1535 RLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
L A++ E++ +L + L ++ ++++ + W++ T + + + S L S+
Sbjct: 1550 ELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA---TDMELTKRSAVEGMPSNLDSE 1606
Query: 1594 HQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSA 1653
+A + E+ ++ + ++G +L + E V+ +L+ L W + ++
Sbjct: 1607 VAWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAE 1664
Query: 1654 EKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI 1712
E L E K + F+ + W+ + + LL E K ++LK+ L+A++
Sbjct: 1665 EWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-DESEKKKPQQKEDVLKR---LKAEL 1720
Query: 1713 SAHEDRLKDLNSQADSLMTSSAFDTSQ-VKDKRDTINGRFQKIKSMAASRRAKLNESHRL 1771
+ ++ QA +LM + + V+ + +N RF I + +A + L
Sbjct: 1721 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-PLKEL 1779
Query: 1772 HQFFRD----MDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
QF D ++ E+ I++ L ED+ +D+ +E ++
Sbjct: 1780 EQFNSDIQKLLEPLEAEIQQGVNLK-EEDFNKDMN----------------EDNEGTVKE 1822
Query: 1828 VLDTG----KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQR-LEESLEYQQFVA 1882
+L G ++++D+ + +I+Q+L Q +H LK L + R ++ LE S ++ Q+
Sbjct: 1823 LLQRGDNLQQRITDERKREEIKIKQQLLQ-TKH-NALKDLRSQRRKKALEISHQWYQYKR 1880
Query: 1883 NVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLI 1942
++ L +D LA++ + + E D + K + + +
Sbjct: 1881 QADD---------LLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK---------EEL 1922
Query: 1943 KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWKADVVESWIGEKE 2001
E +S +G +E Q + E S F QF + E+
Sbjct: 1923 NAVRRQAEGLSE-----DGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREET 1977
Query: 2002 NSLKTDDYGRDLSSV------------QTLLTKQETFDAG-------LQAFQQEGIANIT 2042
+ T+D ++S V Q LL ++ +A F+QE ++
Sbjct: 1978 MMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE--ESLK 2035
Query: 2043 ALKDQLLAAKH----VQSK-------AIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
+KD L + + SK A L + SQL K + Q F
Sbjct: 2036 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 2095
Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA---LREAHDAF------- 2141
+ + + F FN W AE+ L + E K L+E D
Sbjct: 2096 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2155
Query: 2142 RSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKE 2201
R+ ++ + Q ++ D I ++ S W Q++ K+ L
Sbjct: 2156 RTLNATGEEIIQQSSKTDASILQEKLGSLNLRW-------------QEVCKQ----LSDR 2198
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVE--ESGTLESQLEATKRKHQE 2259
++R EE + EF + N F W++E S +E + L+ +LE K +E
Sbjct: 2199 KKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASIPLEPGKEQQLKEKLEQVKLLVEE 2255
Query: 2260 IRAMRSQLKKIEDLGAAM--------EEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQH 2311
+ + LK++ + G + EE L+NK + + QW ++ + Q
Sbjct: 2256 LPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL-----QWIKVSRALPEKQG 2310
Query: 2312 NLEQQIQARNTTGVTEEALKEFSMMFKH 2339
+E QI+ G E+ L++ H
Sbjct: 2311 EIEAQIK---DLGQLEKKLEDLEEQLNH 2335
Score = 109 bits (272), Expect = 4e-23
Identities = 195/995 (19%), Positives = 413/995 (41%), Gaps = 111/995 (11%)
Query: 13 EDIQERRQQVLDRYHRFKELSTLRRQK-LEDSYRFQFFQRDAEELEKWIQE-KLQIASDE 70
E+I+ ++Q + +++ K+L + RR+K LE S+++ ++R A++L K + + + ++AS
Sbjct: 1841 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1900
Query: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS-----ETIRTRLM 125
+D ++ ++ Q + E+ A L E G M E I ++
Sbjct: 1901 EPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFA 1960
Query: 126 ELHRQWELLLEKMREKGIKLLQAQKLVQ-------YLRECEDVMDWINDKEAIVTSEEL- 177
+ R + +RE+ + ++ ++ YL E V + + E ++ + +L
Sbjct: 1961 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 2020
Query: 178 GQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAA 236
+D E + ++ + + + R++ ++ +Q P E + ++ +++
Sbjct: 2021 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ 2080
Query: 237 WQRLKGLALQRQGKLFGAAEV-QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLR 295
W+++ + RQG+ + E +RF+ D+ W+ E EQ + + +
Sbjct: 2081 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2140
Query: 296 KHEGLERDLAALEDKVKALCAEADR-LQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354
E L+ + + V+ L A + +QQS A+ +Q K L W+++ ++R
Sbjct: 2141 LKE-LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2199
Query: 355 ARLNDSYRLQRFLADF-RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHK---GEI 410
RL + + L++F RDL +V ++ N + + + L ++ ++ K E+
Sbjct: 2200 KRLEEQ---KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 2256
Query: 411 DAHEDSFKSADESGQALLAAGHYA---SDEVREKLTVLS---------------EERAAL 452
+ K +E+G +L + + D++ KL + E A +
Sbjct: 2257 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2316
Query: 453 LELWELRRQ---QYEQCMDLQLF---YRDTEQVDNWMSKQEAFLLNED---LGDSLDSVE 503
+L +L ++ EQ L L+ R+ ++ N +++ F + E + VE
Sbjct: 2317 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2376
Query: 504 ALLKKHEDFEKSLSAQEEKITALDEFAT------KLIQNNHYAMEDVA----------TR 547
+L K + K A + L++ ++ +L+Q D+A T+
Sbjct: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2436
Query: 548 RDALLSRRNALHERAMRRRAQLADSFHLQ-----QFFRDSDELKSWVN--EKMKTATDEA 600
L+++ E A+ + ++ S L+ F R EL W++ +++ +
Sbjct: 2437 TVTLVTQPVVTKETAI-SKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2495
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID--VNHYAKDEVAARMNEVIS 658
D ++ + K +A +L + +++ L A Q L + N A+ + R+ + +
Sbjct: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555
Query: 659 LWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVE--------GHLASDDYGKDL 710
W ++ E + N++QQ N ++D WL E + + +
Sbjct: 2556 QWDEVQEHLQ---------NRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2606
Query: 711 TNVQNLQKK---HALLEADVAAHQDRID-GITIQARQFQDAGHFDAENIKKKQEALVARY 766
V +QKK L D+ Q +D + + +D D + E + A +
Sbjct: 2607 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW 2666
Query: 767 EALKEPMVARKQKLADSLRLQQLF-RDVEDEETWIREKEPIA----ASTNRGK---DLIG 818
++ + + R+ L ++ RL Q F D+E W+ E E A +T + + D G
Sbjct: 2667 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG 2726
Query: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE--EGHFAAEDVKAKLHELNQKWEALK 876
V+ L+K+ Q LQ EI H + + ++ EG A ++ +L +N KW L+
Sbjct: 2727 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR 2786
Query: 877 AKASQRRQDLE-DSLQAQQYFADANEAESWMREKE 910
K+ R LE S Q ++ E W++ K+
Sbjct: 2787 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 2821
Score = 100 bits (248), Expect = 2e-20
Identities = 181/943 (19%), Positives = 381/943 (40%), Gaps = 133/943 (14%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD--ENYKDPTNLQGKLQKHQA 87
K+LS +++ E FQRD E W++E IAS E K+ L+ KL++ +
Sbjct: 2193 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ-QLKEKLEQVKL 2251
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASET---IRTRLMELHRQWELLLEKMREKGIK 144
E+ G + +L+ETG ++ + E + +L + + QW + + EK +
Sbjct: 2252 LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE 2311
Query: 145 L-LQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
+ Q + L Q ++ ED+ E+L L + ++ + E +
Sbjct: 2312 IEAQIKDLGQLEKKLEDL------------EEQLNHLLLWLSPIRNQLEIY--------- 2350
Query: 204 RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
N+ NQ +QE E ++ KQ +V + + L ++ Q R
Sbjct: 2351 --NQPNQEGPFDVQET---EIAVQAKQPDVEEILSKGQHLYKEKPA-------TQPVKRK 2398
Query: 264 VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
++ D + +V LL++ + DLA + A + L
Sbjct: 2399 LE----------------DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL-- 2440
Query: 324 SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFR----DLTSWVTE 379
TQ V +E I+ E +L E A LADF +LT W++
Sbjct: 2441 -----VTQPVVTKETAISKLEMPSSLMLEVPA-----------LADFNRAWTELTDWLSL 2484
Query: 380 MKALINADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASD 436
+ +I + + D+ ++ + + +++ + + Q L + A
Sbjct: 2485 LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART 2544
Query: 437 EVREKLTVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLLNEDL 495
+ +++ + + + E + RRQQ + + D + E+ + + + A L +
Sbjct: 2545 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE 2604
Query: 496 GD-SLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSR 554
G ++D+++ + + + K L + + ++ A KL+++ Y+ +D TR+ +++
Sbjct: 2605 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD--YSADD--TRKVHMITE 2660
Query: 555 R-----NALHERAMRRRAQLADSFHL-QQFFRDSDELKSWVNEKMKTAT--------DEA 600
++H+R R A L ++ L QQF D ++ +W+ E TA +
Sbjct: 2661 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 2720
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA--RMNEVIS 658
+D ++ +++ Q + E+ A+ L++ QK++ + D V R++ +
Sbjct: 2721 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2780
Query: 659 LWKKLLEAT-ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNL 716
W +L + + ++ ++Q ++ + +++++ +WL + L+ G D VQ
Sbjct: 2781 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2840
Query: 717 QKKHALLEADVAAHQDRIDGITIQARQFQDAGHFD-----------------AENI---- 755
H + ++ + I R F + A+N+
Sbjct: 2841 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2900
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGK 814
+K+ E + +E L ++K+ ++L RLQ+L ++ + +R+ E I S
Sbjct: 2901 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 2960
Query: 815 DLI--GVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKW 872
DL+ +Q+ L+K +AL+ EIA + + V + G + + L +LN +W
Sbjct: 2961 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 3020
Query: 873 EALKAKASQRRQDLEDSLQ----AQQYFADANEAESWMREKEP 911
+ L+ R + L ++ + A Q+F + W R P
Sbjct: 3021 KLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISP 3063
>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
Length = 3562
Score = 186 bits (473), Expect = 2e-46
Identities = 439/2327 (18%), Positives = 908/2327 (39%), Gaps = 344/2327 (14%)
Query: 19 RQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE---KLQIASDENYKDP 75
+Q D R KEL T+ D+ +Q + W+Q+ KL I + D
Sbjct: 796 KQVFSDVQAREKELQTIF-----DTLPPMRYQETMSAIRTWVQQSETKLSIPQ-LSVTDY 849
Query: 76 TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFA-SETIRTRLMELHRQWELL 134
++ +L + QA ++ +Q + L T M + S ++ E+ +W+ L
Sbjct: 850 EIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKL 909
Query: 135 LEKMREKGIKLL-QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
++ E KL Q KL + + + W+ + + + E L E+L+K+ ++
Sbjct: 910 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEE--WPALGDSEILKKQLKQ 967
Query: 194 FQ---TDMAAHEERVNEVNQFAAKLIQEQHPE-EELIKTKQDEVNAAWQRLKGLALQRQG 249
+ +D+ + +N VN+ K+ E PE ++T+ E+N W + R+
Sbjct: 968 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKE 1027
Query: 250 KLFGAAE-VQRFNRDVDETISWIKEKEQLMASDDFG-RDLASVQALLRKHEGLERDLAAL 307
L G E +D+ E W+ + E+ DF + +Q + + + + +
Sbjct: 1028 ALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQK 1087
Query: 308 EDKVKALCAEADR-LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR-LQR 365
E KVK L + + Q+ P++ ++ + E L TN++ + T RLN + L+
Sbjct: 1088 EAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCT-------RLNGKCKTLEE 1140
Query: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
A + +L S++ + +N E+ + E + +E +D+ E+ + ++++
Sbjct: 1141 VWACWHELLSYLEKANKWLN--EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1198
Query: 426 AL------LAAGHYASDEVREKLTV-------LSEE---RAALLELWELRRQQYEQCM-- 467
+ L G + + E+L L EE R LLE Q+ E+ +
Sbjct: 1199 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1258
Query: 468 --------DLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQ 519
D QL ++VD QEA + DL S+E + K ++ E A
Sbjct: 1259 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKE----AA 1314
Query: 520 EEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFF 579
+ ++ +D KL +DV+ + L ++ A E+ ++ + D +
Sbjct: 1315 QRVLSQIDVAQKKL--------QDVSMK--FRLFQKPANFEQRLQESKMILDEVKMHLPA 1364
Query: 580 RDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLI 639
++ ++ V + YK LS +S ++ + K G++++
Sbjct: 1365 LETKSVEQEVVQSQLNHCVNLYKS-----------------LSEVKSEVEMVIKTGRQIV 1407
Query: 640 DVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ--------QQFNRNVEDIE 691
+ E ++E ++ K L EL G K+ E QQ ++ + + +
Sbjct: 1408 QKK---QTENPKELDERVTALK--LHYNEL-GAKVTERKQQLEKCLKLSRKMRKEMNVLT 1461
Query: 692 LWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA---AHQDRIDGITIQARQFQDAG 748
WL + +LT ++ + L+++VA A Q I+ + + + G
Sbjct: 1462 EWLAATD---------MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1512
Query: 749 HFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL--------QQLFRDVEDEETWI 800
+ KK+ + + L +A + + L L + ++V+ WI
Sbjct: 1513 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 1572
Query: 801 REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT-QKGNAMVEEGHFAAE 859
+ + + + + K +++LK+ L+AE+ P++ + Q N M G +
Sbjct: 1573 IQADTLLDESEKKKPQ-QKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1628
Query: 860 DVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
V+ ++ ELN ++ A+ + + + + +Q+ +D + EP+ G
Sbjct: 1629 LVEPQISELNHRFAAISHRIKTGKASIPLK-ELEQFNSDIQKL------LEPLEAEIQQG 1681
Query: 920 ---KDEDSAEALLKKHEALMSDLSAYGSSIQAL-----REQAQSCRQQVAPTDDETGKEL 971
K+ED + + + +E + +L G ++Q + + +QQ+ T K+L
Sbjct: 1682 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1741
Query: 972 VLALYDYQEKSPREVT-------MKKGDILTLLNSTNK---------DWWKVEVNDRQGF 1015
+ K E++ + D+L L+ K D K++ DR+
Sbjct: 1742 ----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRE-- 1795
Query: 1016 VPAAYVKKLDPAQSASR--ENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELY 1073
KK + + R E L E+ ++A+ QI +S R +++E
Sbjct: 1796 ----LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----------LSKRWREIES-- 1838
Query: 1074 HSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAALTSEEVGADLEQV-EVLQK 1131
KF FR N Q + E+ + +E++ ++ V
Sbjct: 1839 -------------------KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT 1879
Query: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191
+ + L E L + A+D E E ++ ++ D SK +
Sbjct: 1880 EITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAA 1939
Query: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIE 1250
+SA V V ++ +L+ +W + ++ ++R S + +RFH D +W+
Sbjct: 1940 LQSAT-PVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 1998
Query: 1251 EKNQALNT----DNYGHDLASVQALQRKHEGFERDLA-ALGDK---VNSLGETAERLIQ- 1301
E Q L +N+ H K++ + ++L +G + V +L T E +IQ
Sbjct: 1999 EAEQFLRKTQIPENWEH---------AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2049
Query: 1302 SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD-LQRFLSDFRDLMSWINGIRG 1360
S A LQEK LN W + K+ RK +L + + L F D + + W+
Sbjct: 2050 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2109
Query: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKL 1420
+ S + LE+ + E+ R G + + G +L ++P ++
Sbjct: 2110 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV----SAPISPEEQ 2165
Query: 1421 DILDQERADLEKAWVQ-RRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
D L+ + W++ R + ++ E++ +D Q E
Sbjct: 2166 DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE--------------------- 2204
Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
KK ED ++ +N + L +QL +I ++ N+
Sbjct: 2205 -----KKLEDLEEQLN---HLLLWLSPIRNQL---------EIYNQPNQ----------- 2236
Query: 1540 MIEKRSKLGESQTLQQFSR-DVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
E + E++ Q + DV+EI +S+ ++ P +L L S+ +
Sbjct: 2237 --EGPFDVQETEIAVQAKQPDVEEI---LSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 2291
Query: 1599 AFEAELHANA-DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQ 1657
EL A D G+ +G S + K + + K S
Sbjct: 2292 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTK----------ETAISKLEMPSS 2341
Query: 1658 KLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLEADISAHE 1716
+ E +FN + WLS ++ ++ S+ DL +N ++ K + D+
Sbjct: 2342 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2401
Query: 1717 DRLKDLNSQADSLM--TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR-LHQ 1773
+L++L + A +L TS+ + + D+ + I ++ +++ +RR +LNE + Q
Sbjct: 2402 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2461
Query: 1774 FFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTG 1832
+ ++ E + + + + S G + +Q + K+L +L + + D
Sbjct: 2462 WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA 2521
Query: 1833 KKLSDDNTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAW 1890
KL D + + + + W+ + + + R LEE+ QQF ++E+ AW
Sbjct: 2522 LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW 2581
Query: 1891 INEKMTLV-------ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIK 1943
+ E T E + ++ L+K+ + + + H D +++ N Q +++
Sbjct: 2582 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2641
Query: 1944 KNNHHEENI--SSKMKGLNGKVSDLEKAAAQRKAKLDENS-AFLQFNWKADVVESWIGEK 2000
++ + ++ +N K S+L K + ++ L+ +S + + + + W+ K
Sbjct: 2642 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2701
Query: 2001 ENSLKTD-DYGRDLSSVQT-----------LLTKQETFDAGLQAFQ-------QEGIANI 2041
++ L G D +VQ L TK+ + L+ + EG+ +
Sbjct: 2702 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 2761
Query: 2042 TALKDQLLAAKHVQS--KAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKVED 2096
+L + Q+ + + + + W +L +SA ++K+ LE ++ D
Sbjct: 2762 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 2821
Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA 2156
++A ++ + L D ++ + LE++KALR ++ + + + +
Sbjct: 2822 ELDLKLRQAEVIKGSWQPVGDLLIDSLQ-DHLEKVKALR-------GEIAPLKENVSHVN 2873
Query: 2157 ELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQR 2203
+L RQ+ + + +PY T+E L W+ LQ +++R +L + R
Sbjct: 2874 DLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHR 2920
Score = 179 bits (455), Expect = 2e-44
Identities = 457/2309 (19%), Positives = 880/2309 (38%), Gaps = 406/2309 (17%)
Query: 142 GIKLLQAQ-KLVQYLRECEDVMDWINDKEAIVTSE-ELGQDLEHVEVLQKKFEEFQTDMA 199
G L++++ L +Y E+V+ W+ E + ++ E+ D+E V+ E + D+
Sbjct: 208 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 267
Query: 200 AHEERVNEVNQFAAKLI---QEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAE 256
AH+ RV + Q +KLI + EE ++ + + +N+ W+ L+ ++++Q L
Sbjct: 268 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVL- 326
Query: 257 VQRFNRDVDETISWI---KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
+ N+ + E W+ +E+ + M + G DL ++ +++H+ L+ DL + +V +
Sbjct: 327 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 386
Query: 314 L---CAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLND-SYRLQRFLAD 369
L D H +A + Q+K L W I +R L D + QR +
Sbjct: 387 LTHMVVVVDESSGDHATAALEEQLK--VLGDRWANICRWTEDRWVLLQDILLKWQRLTEE 444
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
++W++E + +N H FK +E +L
Sbjct: 445 QCLFSAWLSEKEDAVN-------------------------KIHTTGFKDQNEMLSSL-- 477
Query: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
+KL VL + E ++Q + L+ T + + K EA+
Sbjct: 478 ----------QKLAVLKAD-------LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAW 520
Query: 490 LLN-EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
L N D+L V+ L K ++++ + +T T + V TR
Sbjct: 521 LDNFARCWDNL--VQKLEKSTAQISQAVTTTQPSLTQTTVMET---------VTTVTTRE 569
Query: 549 DALL--SRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK---MKTATDEAYKD 603
L+ ++ ++R DS ++ D EL SW+ +++ ++
Sbjct: 570 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 629
Query: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID--VNH--------YAKDEVAARM 653
N +K A E E + ++ ++ Q L++ VN A +++ +R
Sbjct: 630 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 689
Query: 654 NEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNV 713
E L + L E + + NQ QQ + E WL +++ S+ T +
Sbjct: 690 IEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWL-KIQPTTPSEP-----TAI 743
Query: 714 QNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGH----FDAENIKKKQEALVARYEAL 769
++ K ++ Q +I+ + IQ+ ++ G DA+ + A ++ +
Sbjct: 744 KSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFV-----AFTNHFKQV 798
Query: 770 KEPMVARKQKLA---DSLRLQQLFRDVEDEETWIREKE-PIAASTNRGKDLIGVQNLLKK 825
+ AR+++L D+L + + TW+++ E ++ D ++ L +
Sbjct: 799 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 858
Query: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEG-HFAAEDVKAKLHELNQKWEALKAKASQRRQ 884
QALQ+ + + + ++ M ++ + +++ E+ +W+ L ++ + Q
Sbjct: 859 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 918
Query: 885 DLEDSLQAQQYFAD--------ANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALM 936
LE+ + + + E + +++E+ P +G ++ K + LK+ L+
Sbjct: 919 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ------LKQCRLLV 972
Query: 937 SDLSAYGSSIQALREQAQSCRQQVAP---TDDETGKELVLALYDY--QEKSPREVTMKKG 991
SD+ S+ ++ E Q + + P + ET + + +D+ Q+ R+ +K G
Sbjct: 973 SDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGG 1032
Query: 992 DILTLLNSTNKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSA------SRENLLEEQG 1040
L S KD W + + Y K D Q A ++E +++
Sbjct: 1033 --LEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-KTPDELQKAVEEMKRAKEEAQQKEA 1089
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEEL---YHSL-LELGEKRKGMLEKSCKKFML 1096
+ L E +++ +L+ K++E L Y L L K K + E L
Sbjct: 1090 KVKLLTESVNSVIAQAPPVAQEALK-KELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1148
Query: 1097 FREANELQQWINEKEAAL-TSEEVGADLEQV-EVLQKKFDDFQKDLKANESRLKDINKVA 1154
+ +W+NE E L T+E + E++ EVL D + ++ +E I +A
Sbjct: 1149 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL----DSLENLMRHSEDNPNQIRILA 1204
Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
+ L G+M E L+ + TFNS R
Sbjct: 1205 QTLTDGGVMDE-------------------------------LINEELETFNS------R 1227
Query: 1215 WRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRK 1274
WR L + A R +LL ++ + A ET++ S+ +Q
Sbjct: 1228 WRELHEEAVRRQKLL------EQSIQSAQETEK-------------------SLHLIQES 1262
Query: 1275 HEGFERDLAA-LGDKVNSLGETAE-RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRK 1332
++ LAA + DKV++ E + IQS S E E+ + NQ GK A QR
Sbjct: 1263 LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQ-----GKEAAQRV 1317
Query: 1333 AKLGD--SHDLQRFLSDFRDLMSWINGIRGLVSS----DELAKDVTGAEALLERHQEHRT 1386
D LQ FR N + L S DE+ + E + ++
Sbjct: 1318 LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQS 1377
Query: 1387 EIDARAGTFQAFEQF----------GQQLLAHGHYASP-EIKQKLDILDQERADLEKAWV 1435
+++ +++ + G+Q++ +P E+ +++ L +L
Sbjct: 1378 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVT 1437
Query: 1436 QRRMMLDQCLEL-QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
+R+ L++CL+L + ++ W+AA + L K +++ + + + + KA
Sbjct: 1438 ERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT---KRSAVEGMPSNLDSEVAWGKAT 1494
Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGE----- 1549
+ EK + + G K + + V D+ L + I S+ E
Sbjct: 1495 QKEIEK---QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLL 1551
Query: 1550 ---SQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHA 1606
+ ++ F ++VD I WI + T DES K K K + +AEL+
Sbjct: 1552 LEYQKHMETFDQNVDHITKWIIQ-ADTLLDESEK-------KKPQQKEDVLKRLKAELND 1603
Query: 1607 NADRIRGVIDM-GNSLIERGACAGSEDAVKARLAALADQWQFLVQ--KSAEKSQKLKEAN 1663
++ D N + RG V+ +++ L ++ + K+ + S LKE
Sbjct: 1604 IRPKVDSTRDQAANLMANRG--DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKEL- 1660
Query: 1664 KQQNFNTGIKDFDFWLSEVEA------LLASEDYGKDLASVNNLLKKHQLLEADISAHED 1717
+ FN+ I+ L +EA L ED+ KD+ N E
Sbjct: 1661 --EQFNSDIQKL---LEPLEAEIQQGVNLKEEDFNKDMNEDN----------------EG 1699
Query: 1718 RLKDLNSQADSLM--TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAK-LNESHRLHQF 1774
+K+L + D+L + ++K K+ + + +K + + RR K L SH+ +Q+
Sbjct: 1700 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1759
Query: 1775 FRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLR--KKHKRLEAELAAHEPAIQGVLDTG 1832
R DD LL +D + L + R +K K ++ EL + + V
Sbjct: 1760 KRQADD---------LLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1810
Query: 1833 KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWIN 1892
+ LS+D E Q Q + W+E++ A L + Q EE +
Sbjct: 1811 EGLSEDGAAMAVEPTQ--IQLSKRWREIESKFAQ-----FRRLNFAQIHTVREETMMVMT 1863
Query: 1893 EKMTLVASEDYGDTLAAI----QGLLKKHEAFETDFTVHKD-----RVNDVCTNGQDLIK 1943
E M L S L I Q LL+ + KD + + N +D ++
Sbjct: 1864 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 1923
Query: 1944 KNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENS 2003
+++ + I SK K + L+ A + KL E + L F W EK N
Sbjct: 1924 QSSGRIDIIHSK------KTAALQSATPVERVKLQEALSQLDFQW----------EKVNK 1967
Query: 2004 LKTDDYGR-------------DLSSVQTLLTKQETFDAGLQAFQ--------------QE 2036
+ D GR D+ LT+ E F Q + Q+
Sbjct: 1968 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2027
Query: 2037 GIA-------NITALKDQLL-AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ 2088
GI + A ++++ + + ++ + SL RW ++ + RKK+L E
Sbjct: 2028 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ- 2086
Query: 2089 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA 2148
+++ F + + F W E A+ + P+ +++K E L
Sbjct: 2087 ------KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLR 2140
Query: 2149 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEE-------TWRNLQKIIKERELELQKE 2201
Q QL E + + S P + + LE W + + + E++ E++ +
Sbjct: 2141 QGILKQLNETGGPV----LVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQ 2196
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYL-------LDGSCMVEES--------GTL 2246
+ + +K ++ + N W+ R L +G V+E+ +
Sbjct: 2197 IKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDV 2256
Query: 2247 ESQLEATKRKHQEIRAMRSQLKKIEDLGA 2275
E L + ++E A + +K+EDL +
Sbjct: 2257 EEILSKGQHLYKEKPATQPVKRKLEDLSS 2285
Score = 157 bits (396), Expect = 2e-37
Identities = 438/2401 (18%), Positives = 922/2401 (38%), Gaps = 386/2401 (16%)
Query: 49 FQRDAEE---LEKWIQEKLQIASD---ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKL 102
+QR EE W+ EK + +KD + LQK +A+++ ++ KL
Sbjct: 438 WQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 497
Query: 103 DETGNLMISEGHFASETIRTR--LMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED 160
++S S T +T L R W+ L++K+ + ++ QA Q
Sbjct: 498 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 557
Query: 161 VMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQH 220
VM+ + VT+ E Q K QE+
Sbjct: 558 VMETVTT----VTTRE---------------------------------QILVKHAQEEL 580
Query: 221 PEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMAS 280
P K +Q V++ ++ R + D+ E SWI E ++ S
Sbjct: 581 PPPPPQKKRQITVDSEIRK-------------------RLDVDITELHSWITRSEAVLQS 621
Query: 281 DDFG--RDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ---SHPLSATQIQVK 335
+F R + L K +ER+ A K++ A L + + ++A I+
Sbjct: 622 PEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQA 681
Query: 336 REELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA-SDVA 394
E+L + W + L +ER L + F + L T + + S+
Sbjct: 682 SEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 741
Query: 395 GAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
++ L ++ + + + AL G + + + + +
Sbjct: 742 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSD 801
Query: 455 LWELRRQQYEQCMDL--QLFYRDT-EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
+ + R ++ + D + Y++T + W+ + E L L S+ E + ++ +
Sbjct: 802 V-QAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL--SVTDYEIMEQRLGE 858
Query: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA----LLSRRNALHERAMRRRA 567
+ S+ +E+ + L +T + + + A +++ + + + R L + +
Sbjct: 859 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 918
Query: 568 QLADSFH-LQQFFRDSDELKSWVNEKMKTATDE--AYKDPSNLQGKVQKHQAFEAELSAN 624
+L + + L++ LK W+ E +E A D L+ ++++ + +++
Sbjct: 919 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 978
Query: 625 QSRIDALEKAGQKLIDVNHYAKDEVAARMN----EVISLWKKLLEATELKGIKLREANQQ 680
Q ++++ + GQK + + A+ E A+R+ E+ + W + + + L+ ++
Sbjct: 979 QPSLNSVNEGGQK---IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1035
Query: 681 Q-QFNRNVEDIELWLYEVEG--------HLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+++ ++ W+ + E + D+ K + ++ +++ EA V
Sbjct: 1036 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1095
Query: 732 DRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL-QQLF 790
+ ++ + QA E +KK+ E L Y+ L + + + L + +L
Sbjct: 1096 ESVNSVIAQAPPVAQ------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELL 1149
Query: 791 RDVEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
+E W+ E E + + N + +L + L + +I+ + Q
Sbjct: 1150 SYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT--- 1206
Query: 850 MVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREK 909
+ +G E + +L N +W L +A +R++ LE S+Q+ Q + ++ ++E
Sbjct: 1207 -LTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ---ETEKSLHLIQES 1262
Query: 910 EPIVGS--TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
+ Y D+ A + ++ + + SDL+++ S++ +++ Q +
Sbjct: 1263 LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG----------KE 1312
Query: 968 GKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQGFVPAAYVKKLDP 1026
+ VL+ D +K ++V+MK N + K+ +++ + +PA K ++
Sbjct: 1313 AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1372
Query: 1027 AQSASR----ENLLEEQGSIALRQEQIDN------QTRITKEAGSVSLRMKQVEELYHSL 1076
S+ NL + + E + Q + T+ + R+ ++ Y+ L
Sbjct: 1373 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1432
Query: 1077 LELGEKRKGMLEKSCKKFMLFR-EANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDD 1135
+RK LEK K R E N L +W+ + LT VE + D
Sbjct: 1433 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA------VEGMPSNLDS 1486
Query: 1136 -------FQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
QK+++ + LK I +V E L++ ++ + ET
Sbjct: 1487 EVAWGKATQKEIEKQKVHLKSITEVGEALKT------------------VLGKKET---- 1524
Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEE-RSQLLGSAHEVQRFHRDADETKE 1247
+ + LN W ++ AEE + LL ++ F ++ D +
Sbjct: 1525 --------------LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 1570
Query: 1248 WIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGD---KVNSLGETAERLIQSHP 1304
WI + + L D + + Q+K + +R A L D KV+S + A L+ +
Sbjct: 1571 WIIQADTLL-------DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG 1623
Query: 1305 ESAEDLQE-KCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
+ L E + +ELN ++++ R KA + +L++F SD + L+ +
Sbjct: 1624 DHCRKLVEPQISELNHRFAAISHRIKTGKASI-PLKELEQFNSDIQKLLEPLEA------ 1676
Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GHYASPEIKQKLD 1421
E+ + V E + E GT + Q G L EIK K
Sbjct: 1677 --EIQQGVNLKEEDFNKDMNEDNE-----GTVKELLQRGDNLQQRITDERKREEIKIKQQ 1729
Query: 1422 ILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVE 1481
+L + L+ QRR L++ H+ W + +D LD +E
Sbjct: 1730 LLQTKHNALKDLRSQRRKKA-----LEISHQ-------WYQYKR---QADDLLKCLDDIE 1774
Query: 1482 ALI---------KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDR 1532
+ +K ++ D+ + ++E++ A++ A+ L G A + + ++ R
Sbjct: 1775 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDG--AAMAVEPTQIQLSKR 1832
Query: 1533 WRRLKAQMIE-KRSKLGESQTLQQFSRDV--DEIEAWIS--------------------E 1569
WR ++++ + +R + T+++ + V +++ IS E
Sbjct: 1833 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 1892
Query: 1570 KLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAG 1629
+L A D KD L + + + + L ++ RI +I + + A
Sbjct: 1893 QLLNAPDLCAKD-----FEDLFKQEESLKNIKDSLQQSSGRI-DIIHSKKTAALQSATPV 1946
Query: 1630 SEDAVKARLAALADQWQFLVQKSAEKSQKL-KEANKQQNFNTGIKDFDFWLSEVEALLAS 1688
++ L+ L QW+ + + ++ + + K + F+ IK F+ WL+E E L
Sbjct: 1947 ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK 2006
Query: 1689 EDYGKDL--ASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRD 1745
++ A LK+ L+ I + ++ LN+ + ++ SS D S +++K
Sbjct: 2007 TQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2063
Query: 1746 TINGRFQKIKSMAASRRAKLNESHR-LHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTG 1803
++N R+Q++ + R+ +L E L +F RD+++ W++E + + G++
Sbjct: 2064 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE--- 2120
Query: 1804 VQNLRKKHKRLEAELAAHEPAIQGVL----DTGKKLSDDNTIGKEE---IQQRLAQFVEH 1856
Q L++K ++++ L P QG+L +TG + I EE ++ +L Q
Sbjct: 2121 -QQLKEKLEQVKL-LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2178
Query: 1857 W-KELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLK 1915
W K + L +G+ + + Q +E+ E +N + ++ +
Sbjct: 2179 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG 2238
Query: 1916 KHEAFETDFTVHKDR--VNDVCTNGQDLIKKNNHHE------ENISSKMKGLNGKVSDLE 1967
+ ET+ V + V ++ + GQ L K+ + E++SS+ K +N + +L
Sbjct: 2239 PFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELR 2298
Query: 1968 ------------------------------KAAAQRKAKLD-----ENSAFLQFNWKADV 1992
K A K ++ E A FN
Sbjct: 2299 AKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTE 2358
Query: 1993 VESWIGEKENSLKTDDYG-RDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2051
+ W+ + +K+ DL + ++ KQ+ A +Q +Q L++ + AA
Sbjct: 2359 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK---ATMQDLEQRR----PQLEELITAA 2411
Query: 2052 KHVQSKA--------IEARHASLMKRWSQLLANSAARKKKLLE----AQSHFRKVEDLFL 2099
+++++K I R + +W ++ + R+++L E + E+
Sbjct: 2412 QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 2471
Query: 2100 TFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELD 2159
+ + SW E D ++ + E K L + +++++ A N LA
Sbjct: 2472 VLGQARAKLESWKEGPYT--VDAIQ-KKITETKQLAKDLRQWQTNVDVA----NDLAL-- 2522
Query: 2160 RQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHA 2219
+ ++ + E + +WR++ K + ERE L EE +L Q+F
Sbjct: 2523 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL-------EETHRLLQQFPLDL 2575
Query: 2220 NAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKH--QEIRAMRSQLKKIEDLGAAM 2277
F W+ E T T +AT+++ ++ + ++ +K+ +DL +
Sbjct: 2576 EKFLAWLTEAET-------------TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2622
Query: 2278 E 2278
E
Sbjct: 2623 E 2623
Score = 116 bits (291), Expect = 2e-25
Identities = 398/2188 (18%), Positives = 823/2188 (37%), Gaps = 388/2188 (17%)
Query: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINAD-ELASDVAGAEALLDRHQEHKGEIDAHED 415
+ L R+ ++ SW+ + + A E+++DV + H+ + ++ AH+
Sbjct: 212 MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQG 271
Query: 416 SFKSADESGQALLAAGHYASDE---VREKLTVLSEERAAL-LELWELRRQQYEQCMDLQL 471
+ + G L+ G + DE V+E++ +L+ L + E + + MDLQ
Sbjct: 272 RVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ- 330
Query: 472 FYRDTEQVDNWMSKQEAF---LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528
+ +++++W++K E + E LG L+ ++ +++H+ ++ L ++ ++ +L
Sbjct: 331 -NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTH 389
Query: 529 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHL--QQFFRDSDELK 586
+ +++ + +L R A R R L L Q+ +
Sbjct: 390 MVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 449
Query: 587 SWVNEKMKTATD---EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNH 643
+W++EK +KD + + +QK +A+L EK Q
Sbjct: 450 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADL----------EKKKQS------ 493
Query: 644 YAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLAS 703
M ++ SL + LL + K + + E WL
Sbjct: 494 ---------MGKLYSLKQDLLSTLKNKSV--------------TQKTEAWL--------- 521
Query: 704 DDYGKDLTN-VQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEAL 762
D++ + N VQ L+K A + V Q + T+ + +++ L
Sbjct: 522 DNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET---------VTTVTTREQIL 572
Query: 763 V--ARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG--KDLIG 818
V A+ E P ++Q DS ++L D+ + +WI E + S +
Sbjct: 573 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGN 632
Query: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE---GHFAAEDVKAKLHELNQKWEAL 875
+L +K A++ E A +++ ++ A+VE+ A+ +K +LN +W
Sbjct: 633 FSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEF 692
Query: 876 KAKASQRRQDLEDSL-------QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEAL 928
S+R LE Q QQ AE+W++ +P S + + ++
Sbjct: 693 CQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI-QPTTPS-----EPTAIKSQ 746
Query: 929 LKKHEALMSDLSAYGSSIQALREQAQSCRQQ-VAPTDDETGKELVLALYDYQEKSPREVT 987
LK + ++ LS I+ L+ Q+ + +++ P + +A ++ ++ +V
Sbjct: 747 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDAD---FVAFTNHFKQVFSDVQ 803
Query: 988 MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQ-GSIALRQ 1046
++ ++ T+ ++ ++ ++ + +V + K P S + ++E++ G + Q
Sbjct: 804 AREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQ 863
Query: 1047 EQIDNQT-----------RITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
+ Q ++K+A S R Q E + + +K L + C+K
Sbjct: 864 SSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE--FEEIEGRWKKLSSQLVEHCQK-- 919
Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAE 1155
L + N+L++ N ++ L+K + LK L D + +
Sbjct: 920 LEEQMNKLRKIQNH----------------IQTLKKWMAEVDVFLKEEWPALGDSEILKK 963
Query: 1156 DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERW 1215
L+ L+ ++Q +Q + + + A P ++RL +KELN +W
Sbjct: 964 QLKQCRLLVSDIQTIQPS-LNSVNEGGQKIKNEAEPEFASRLETE-------LKELNTQW 1015
Query: 1216 RSL-QQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA-----SVQ 1269
+ QQ+ + L G + +D E EW+ + + ++ + +V+
Sbjct: 1016 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1075
Query: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAED-------------------L 1310
++R E ++ A KV L E+ +I P A++ L
Sbjct: 1076 EMKRAKEEAQQKEA----KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL 1131
Query: 1311 QEKCTELNQAWS----------SLGKRADQRKAKL-------GDSHDLQRFLSDFRDLMS 1353
KC L + W+ K ++ + KL G + ++ L +LM
Sbjct: 1132 NGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMR 1191
Query: 1354 WI----NGIRGLVSS----------------------DELAKDVTGAEALLERH------ 1381
N IR L + EL ++ + LLE+
Sbjct: 1192 HSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE 1251
Query: 1382 --------QEHRTEIDARAGTF-----------QAFEQFGQQLLAHGHYASPEIKQKLDI 1422
QE T ID + + Q ++ L +H + E+K+
Sbjct: 1252 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSH-EISLEEMKKHNQG 1310
Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDC--EQA--ENWMAAREAFLNT---EDKGD 1475
+ + L + V ++ + D ++ +LF + EQ E+ M E ++ E K
Sbjct: 1311 KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSV 1370
Query: 1476 SLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG-DISSRRNEVLDRWR 1534
+ V++ + + K+++ + ++ + Q++ ++ R + +
Sbjct: 1371 EQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 1430
Query: 1535 RLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
L A++ E++ +L + L ++ ++++ + W++ T + + + S L S+
Sbjct: 1431 ELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA---TDMELTKRSAVEGMPSNLDSE 1487
Query: 1594 HQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSA 1653
+A + E+ ++ + ++G +L + E V+ +L+ L W + ++
Sbjct: 1488 VAWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAE 1545
Query: 1654 EKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI 1712
E L E K + F+ + W+ + + LL E K ++LK+ L+A++
Sbjct: 1546 EWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-DESEKKKPQQKEDVLKR---LKAEL 1601
Query: 1713 SAHEDRLKDLNSQADSLMTSSAFDTSQ-VKDKRDTINGRFQKIKSMAASRRAKLNESHRL 1771
+ ++ QA +LM + + V+ + +N RF I + +A + L
Sbjct: 1602 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-PLKEL 1660
Query: 1772 HQFFRD----MDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
QF D ++ E+ I++ L ED+ +D+ +E ++
Sbjct: 1661 EQFNSDIQKLLEPLEAEIQQGVNLK-EEDFNKDMN----------------EDNEGTVKE 1703
Query: 1828 VLDTG----KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQR-LEESLEYQQFVA 1882
+L G ++++D+ + +I+Q+L Q +H LK L + R ++ LE S ++ Q+
Sbjct: 1704 LLQRGDNLQQRITDERKREEIKIKQQLLQ-TKH-NALKDLRSQRRKKALEISHQWYQYKR 1761
Query: 1883 NVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLI 1942
++ L +D LA++ + + E D + K + + +
Sbjct: 1762 QADD---------LLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK---------EEL 1803
Query: 1943 KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWKADVVESWIGEKE 2001
E +S +G +E Q + E S F QF + E+
Sbjct: 1804 NAVRRQAEGLSE-----DGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREET 1858
Query: 2002 NSLKTDDYGRDLSSV------------QTLLTKQETFDAG-------LQAFQQEGIANIT 2042
+ T+D ++S V Q LL ++ +A F+QE ++
Sbjct: 1859 MMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE--ESLK 1916
Query: 2043 ALKDQLLAAKH----VQSK-------AIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
+KD L + + SK A L + SQL K + Q F
Sbjct: 1917 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 1976
Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA---LREAHDAF------- 2141
+ + + F FN W AE+ L + E K L+E D
Sbjct: 1977 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2036
Query: 2142 RSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKE 2201
R+ ++ + Q ++ D I ++ S W Q++ K+ L
Sbjct: 2037 RTLNATGEEIIQQSSKTDASILQEKLGSLNLRW-------------QEVCKQ----LSDR 2079
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVE--ESGTLESQLEATKRKHQE 2259
++R EE + EF + N F W++E S +E + L+ +LE K +E
Sbjct: 2080 KKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASIPLEPGKEQQLKEKLEQVKLLVEE 2136
Query: 2260 IRAMRSQLKKIEDLGAAM--------EEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQH 2311
+ + LK++ + G + EE L+NK + + QW ++ + Q
Sbjct: 2137 LPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL-----QWIKVSRALPEKQG 2191
Query: 2312 NLEQQIQARNTTGVTEEALKEFSMMFKH 2339
+E QI+ G E+ L++ H
Sbjct: 2192 EIEAQIK---DLGQLEKKLEDLEEQLNH 2216
Score = 109 bits (272), Expect = 4e-23
Identities = 195/995 (19%), Positives = 413/995 (41%), Gaps = 111/995 (11%)
Query: 13 EDIQERRQQVLDRYHRFKELSTLRRQK-LEDSYRFQFFQRDAEELEKWIQE-KLQIASDE 70
E+I+ ++Q + +++ K+L + RR+K LE S+++ ++R A++L K + + + ++AS
Sbjct: 1722 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1781
Query: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS-----ETIRTRLM 125
+D ++ ++ Q + E+ A L E G M E I ++
Sbjct: 1782 EPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFA 1841
Query: 126 ELHRQWELLLEKMREKGIKLLQAQKLVQ-------YLRECEDVMDWINDKEAIVTSEEL- 177
+ R + +RE+ + ++ ++ YL E V + + E ++ + +L
Sbjct: 1842 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 1901
Query: 178 GQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAA 236
+D E + ++ + + + R++ ++ +Q P E + ++ +++
Sbjct: 1902 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ 1961
Query: 237 WQRLKGLALQRQGKLFGAAEV-QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLR 295
W+++ + RQG+ + E +RF+ D+ W+ E EQ + + +
Sbjct: 1962 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2021
Query: 296 KHEGLERDLAALEDKVKALCAEADR-LQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354
E L+ + + V+ L A + +QQS A+ +Q K L W+++ ++R
Sbjct: 2022 LKE-LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2080
Query: 355 ARLNDSYRLQRFLADF-RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHK---GEI 410
RL + + L++F RDL +V ++ N + + + L ++ ++ K E+
Sbjct: 2081 KRLEEQ---KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 2137
Query: 411 DAHEDSFKSADESGQALLAAGHYA---SDEVREKLTVLS---------------EERAAL 452
+ K +E+G +L + + D++ KL + E A +
Sbjct: 2138 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2197
Query: 453 LELWELRRQ---QYEQCMDLQLF---YRDTEQVDNWMSKQEAFLLNED---LGDSLDSVE 503
+L +L ++ EQ L L+ R+ ++ N +++ F + E + VE
Sbjct: 2198 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2257
Query: 504 ALLKKHEDFEKSLSAQEEKITALDEFAT------KLIQNNHYAMEDVA----------TR 547
+L K + K A + L++ ++ +L+Q D+A T+
Sbjct: 2258 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2317
Query: 548 RDALLSRRNALHERAMRRRAQLADSFHLQ-----QFFRDSDELKSWVN--EKMKTATDEA 600
L+++ E A+ + ++ S L+ F R EL W++ +++ +
Sbjct: 2318 TVTLVTQPVVTKETAI-SKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2376
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID--VNHYAKDEVAARMNEVIS 658
D ++ + K +A +L + +++ L A Q L + N A+ + R+ + +
Sbjct: 2377 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2436
Query: 659 LWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVE--------GHLASDDYGKDL 710
W ++ E + N++QQ N ++D WL E + + +
Sbjct: 2437 QWDEVQEHLQ---------NRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2487
Query: 711 TNVQNLQKK---HALLEADVAAHQDRID-GITIQARQFQDAGHFDAENIKKKQEALVARY 766
V +QKK L D+ Q +D + + +D D + E + A +
Sbjct: 2488 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW 2547
Query: 767 EALKEPMVARKQKLADSLRLQQLF-RDVEDEETWIREKEPIA----ASTNRGK---DLIG 818
++ + + R+ L ++ RL Q F D+E W+ E E A +T + + D G
Sbjct: 2548 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG 2607
Query: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE--EGHFAAEDVKAKLHELNQKWEALK 876
V+ L+K+ Q LQ EI H + + ++ EG A ++ +L +N KW L+
Sbjct: 2608 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR 2667
Query: 877 AKASQRRQDLE-DSLQAQQYFADANEAESWMREKE 910
K+ R LE S Q ++ E W++ K+
Sbjct: 2668 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 2702
Score = 100 bits (248), Expect = 2e-20
Identities = 181/943 (19%), Positives = 381/943 (40%), Gaps = 133/943 (14%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD--ENYKDPTNLQGKLQKHQA 87
K+LS +++ E FQRD E W++E IAS E K+ L+ KL++ +
Sbjct: 2074 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ-QLKEKLEQVKL 2132
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASET---IRTRLMELHRQWELLLEKMREKGIK 144
E+ G + +L+ETG ++ + E + +L + + QW + + EK +
Sbjct: 2133 LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE 2192
Query: 145 L-LQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
+ Q + L Q ++ ED+ E+L L + ++ + E +
Sbjct: 2193 IEAQIKDLGQLEKKLEDL------------EEQLNHLLLWLSPIRNQLEIY--------- 2231
Query: 204 RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
N+ NQ +QE E ++ KQ +V + + L ++ Q R
Sbjct: 2232 --NQPNQEGPFDVQET---EIAVQAKQPDVEEILSKGQHLYKEKPA-------TQPVKRK 2279
Query: 264 VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
++ D + +V LL++ + DLA + A + L
Sbjct: 2280 LE----------------DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL-- 2321
Query: 324 SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFR----DLTSWVTE 379
TQ V +E I+ E +L E A LADF +LT W++
Sbjct: 2322 -----VTQPVVTKETAISKLEMPSSLMLEVPA-----------LADFNRAWTELTDWLSL 2365
Query: 380 MKALINADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASD 436
+ +I + + D+ ++ + + +++ + + Q L + A
Sbjct: 2366 LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART 2425
Query: 437 EVREKLTVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLLNEDL 495
+ +++ + + + E + RRQQ + + D + E+ + + + A L +
Sbjct: 2426 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE 2485
Query: 496 GD-SLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSR 554
G ++D+++ + + + K L + + ++ A KL+++ Y+ +D TR+ +++
Sbjct: 2486 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD--YSADD--TRKVHMITE 2541
Query: 555 R-----NALHERAMRRRAQLADSFHL-QQFFRDSDELKSWVNEKMKTAT--------DEA 600
++H+R R A L ++ L QQF D ++ +W+ E TA +
Sbjct: 2542 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 2601
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA--RMNEVIS 658
+D ++ +++ Q + E+ A+ L++ QK++ + D V R++ +
Sbjct: 2602 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2661
Query: 659 LWKKLLEAT-ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNL 716
W +L + + ++ ++Q ++ + +++++ +WL + L+ G D VQ
Sbjct: 2662 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2721
Query: 717 QKKHALLEADVAAHQDRIDGITIQARQFQDAGHFD-----------------AENI---- 755
H + ++ + I R F + A+N+
Sbjct: 2722 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2781
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGK 814
+K+ E + +E L ++K+ ++L RLQ+L ++ + +R+ E I S
Sbjct: 2782 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 2841
Query: 815 DLI--GVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKW 872
DL+ +Q+ L+K +AL+ EIA + + V + G + + L +LN +W
Sbjct: 2842 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 2901
Query: 873 EALKAKASQRRQDLEDSLQ----AQQYFADANEAESWMREKEP 911
+ L+ R + L ++ + A Q+F + W R P
Sbjct: 2902 KLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISP 2944
>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
Length = 3685
Score = 186 bits (473), Expect = 2e-46
Identities = 439/2327 (18%), Positives = 908/2327 (39%), Gaps = 344/2327 (14%)
Query: 19 RQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE---KLQIASDENYKDP 75
+Q D R KEL T+ D+ +Q + W+Q+ KL I + D
Sbjct: 919 KQVFSDVQAREKELQTIF-----DTLPPMRYQETMSAIRTWVQQSETKLSIPQ-LSVTDY 972
Query: 76 TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFA-SETIRTRLMELHRQWELL 134
++ +L + QA ++ +Q + L T M + S ++ E+ +W+ L
Sbjct: 973 EIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKL 1032
Query: 135 LEKMREKGIKLL-QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
++ E KL Q KL + + + W+ + + + E L E+L+K+ ++
Sbjct: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEE--WPALGDSEILKKQLKQ 1090
Query: 194 FQ---TDMAAHEERVNEVNQFAAKLIQEQHPE-EELIKTKQDEVNAAWQRLKGLALQRQG 249
+ +D+ + +N VN+ K+ E PE ++T+ E+N W + R+
Sbjct: 1091 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKE 1150
Query: 250 KLFGAAE-VQRFNRDVDETISWIKEKEQLMASDDFG-RDLASVQALLRKHEGLERDLAAL 307
L G E +D+ E W+ + E+ DF + +Q + + + + +
Sbjct: 1151 ALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQK 1210
Query: 308 EDKVKALCAEADR-LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR-LQR 365
E KVK L + + Q+ P++ ++ + E L TN++ + T RLN + L+
Sbjct: 1211 EAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCT-------RLNGKCKTLEE 1263
Query: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
A + +L S++ + +N E+ + E + +E +D+ E+ + ++++
Sbjct: 1264 VWACWHELLSYLEKANKWLN--EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1321
Query: 426 AL------LAAGHYASDEVREKLTV-------LSEE---RAALLELWELRRQQYEQCM-- 467
+ L G + + E+L L EE R LLE Q+ E+ +
Sbjct: 1322 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1381
Query: 468 --------DLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQ 519
D QL ++VD QEA + DL S+E + K ++ E A
Sbjct: 1382 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKE----AA 1437
Query: 520 EEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFF 579
+ ++ +D KL +DV+ + L ++ A E+ ++ + D +
Sbjct: 1438 QRVLSQIDVAQKKL--------QDVSMK--FRLFQKPANFEQRLQESKMILDEVKMHLPA 1487
Query: 580 RDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLI 639
++ ++ V + YK LS +S ++ + K G++++
Sbjct: 1488 LETKSVEQEVVQSQLNHCVNLYKS-----------------LSEVKSEVEMVIKTGRQIV 1530
Query: 640 DVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ--------QQFNRNVEDIE 691
+ E ++E ++ K L EL G K+ E QQ ++ + + +
Sbjct: 1531 QKK---QTENPKELDERVTALK--LHYNEL-GAKVTERKQQLEKCLKLSRKMRKEMNVLT 1584
Query: 692 LWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA---AHQDRIDGITIQARQFQDAG 748
WL + +LT ++ + L+++VA A Q I+ + + + G
Sbjct: 1585 EWLAATD---------MELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1635
Query: 749 HFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL--------QQLFRDVEDEETWI 800
+ KK+ + + L +A + + L L + ++V+ WI
Sbjct: 1636 EALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI 1695
Query: 801 REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT-QKGNAMVEEGHFAAE 859
+ + + + + K +++LK+ L+AE+ P++ + Q N M G +
Sbjct: 1696 IQADTLLDESEKKKPQ-QKEDVLKR---LKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1751
Query: 860 DVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
V+ ++ ELN ++ A+ + + + + +Q+ +D + EP+ G
Sbjct: 1752 LVEPQISELNHRFAAISHRIKTGKASIPLK-ELEQFNSDIQKL------LEPLEAEIQQG 1804
Query: 920 ---KDEDSAEALLKKHEALMSDLSAYGSSIQAL-----REQAQSCRQQVAPTDDETGKEL 971
K+ED + + + +E + +L G ++Q + + +QQ+ T K+L
Sbjct: 1805 VNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1864
Query: 972 VLALYDYQEKSPREVT-------MKKGDILTLLNSTNK---------DWWKVEVNDRQGF 1015
+ K E++ + D+L L+ K D K++ DR+
Sbjct: 1865 ----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRE-- 1918
Query: 1016 VPAAYVKKLDPAQSASR--ENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELY 1073
KK + + R E L E+ ++A+ QI +S R +++E
Sbjct: 1919 ----LQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----------LSKRWREIES-- 1961
Query: 1074 HSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAALTSEEVGADLEQV-EVLQK 1131
KF FR N Q + E+ + +E++ ++ V
Sbjct: 1962 -------------------KFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLT 2002
Query: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191
+ + L E L + A+D E E ++ ++ D SK +
Sbjct: 2003 EITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAA 2062
Query: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIE 1250
+SA V V ++ +L+ +W + ++ ++R S + +RFH D +W+
Sbjct: 2063 LQSAT-PVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2121
Query: 1251 EKNQALNT----DNYGHDLASVQALQRKHEGFERDLA-ALGDK---VNSLGETAERLIQ- 1301
E Q L +N+ H K++ + ++L +G + V +L T E +IQ
Sbjct: 2122 EAEQFLRKTQIPENWEH---------AKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2172
Query: 1302 SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD-LQRFLSDFRDLMSWINGIRG 1360
S A LQEK LN W + K+ RK +L + + L F D + + W+
Sbjct: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2232
Query: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKL 1420
+ S + LE+ + E+ R G + + G +L ++P ++
Sbjct: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV----SAPISPEEQ 2288
Query: 1421 DILDQERADLEKAWVQ-RRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
D L+ + W++ R + ++ E++ +D Q E
Sbjct: 2289 DKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE--------------------- 2327
Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
KK ED ++ +N + L +QL +I ++ N+
Sbjct: 2328 -----KKLEDLEEQLN---HLLLWLSPIRNQL---------EIYNQPNQ----------- 2359
Query: 1540 MIEKRSKLGESQTLQQFSR-DVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
E + E++ Q + DV+EI +S+ ++ P +L L S+ +
Sbjct: 2360 --EGPFDVQETEIAVQAKQPDVEEI---LSKGQHLYKEKPATQPVKRKLEDLSSEWKAVN 2414
Query: 1599 AFEAELHANA-DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQ 1657
EL A D G+ +G S + K + + K S
Sbjct: 2415 RLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTK----------ETAISKLEMPSS 2464
Query: 1658 KLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLEADISAHE 1716
+ E +FN + WLS ++ ++ S+ DL +N ++ K + D+
Sbjct: 2465 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2524
Query: 1717 DRLKDLNSQADSLM--TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR-LHQ 1773
+L++L + A +L TS+ + + D+ + I ++ +++ +RR +LNE + Q
Sbjct: 2525 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2584
Query: 1774 FFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTG 1832
+ ++ E + + + + S G + +Q + K+L +L + + D
Sbjct: 2585 WLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLA 2644
Query: 1833 KKLSDDNTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAW 1890
KL D + + + + W+ + + + R LEE+ QQF ++E+ AW
Sbjct: 2645 LKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAW 2704
Query: 1891 INEKMTLV-------ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIK 1943
+ E T E + ++ L+K+ + + + H D +++ N Q +++
Sbjct: 2705 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2764
Query: 1944 KNNHHEENI--SSKMKGLNGKVSDLEKAAAQRKAKLDENS-AFLQFNWKADVVESWIGEK 2000
++ + ++ +N K S+L K + ++ L+ +S + + + + W+ K
Sbjct: 2765 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2824
Query: 2001 ENSLKTD-DYGRDLSSVQT-----------LLTKQETFDAGLQAFQ-------QEGIANI 2041
++ L G D +VQ L TK+ + L+ + EG+ +
Sbjct: 2825 DDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKL 2884
Query: 2042 TALKDQLLAAKHVQS--KAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKVED 2096
+L + Q+ + + + + W +L +SA ++K+ LE ++ D
Sbjct: 2885 YQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD 2944
Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA 2156
++A ++ + L D ++ + LE++KALR ++ + + + +
Sbjct: 2945 ELDLKLRQAEVIKGSWQPVGDLLIDSLQ-DHLEKVKALR-------GEIAPLKENVSHVN 2996
Query: 2157 ELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQR 2203
+L RQ+ + + +PY T+E L W+ LQ +++R +L + R
Sbjct: 2997 DLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHR 3043
Score = 179 bits (455), Expect = 2e-44
Identities = 457/2309 (19%), Positives = 880/2309 (38%), Gaps = 406/2309 (17%)
Query: 142 GIKLLQAQ-KLVQYLRECEDVMDWINDKEAIVTSE-ELGQDLEHVEVLQKKFEEFQTDMA 199
G L++++ L +Y E+V+ W+ E + ++ E+ D+E V+ E + D+
Sbjct: 331 GSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLT 390
Query: 200 AHEERVNEVNQFAAKLI---QEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAE 256
AH+ RV + Q +KLI + EE ++ + + +N+ W+ L+ ++++Q L
Sbjct: 391 AHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVL- 449
Query: 257 VQRFNRDVDETISWI---KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
+ N+ + E W+ +E+ + M + G DL ++ +++H+ L+ DL + +V +
Sbjct: 450 MDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509
Query: 314 L---CAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLND-SYRLQRFLAD 369
L D H +A + Q+K L W I +R L D + QR +
Sbjct: 510 LTHMVVVVDESSGDHATAALEEQLK--VLGDRWANICRWTEDRWVLLQDILLKWQRLTEE 567
Query: 370 FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
++W++E + +N H FK +E +L
Sbjct: 568 QCLFSAWLSEKEDAVN-------------------------KIHTTGFKDQNEMLSSL-- 600
Query: 430 AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
+KL VL + E ++Q + L+ T + + K EA+
Sbjct: 601 ----------QKLAVLKAD-------LEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAW 643
Query: 490 LLN-EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
L N D+L V+ L K ++++ + +T T + V TR
Sbjct: 644 LDNFARCWDNL--VQKLEKSTAQISQAVTTTQPSLTQTTVMET---------VTTVTTRE 692
Query: 549 DALL--SRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK---MKTATDEAYKD 603
L+ ++ ++R DS ++ D EL SW+ +++ ++
Sbjct: 693 QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRK 752
Query: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID--VNH--------YAKDEVAARM 653
N +K A E E + ++ ++ Q L++ VN A +++ +R
Sbjct: 753 EGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRW 812
Query: 654 NEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNV 713
E L + L E + + NQ QQ + E WL +++ S+ T +
Sbjct: 813 IEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWL-KIQPTTPSEP-----TAI 866
Query: 714 QNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGH----FDAENIKKKQEALVARYEAL 769
++ K ++ Q +I+ + IQ+ ++ G DA+ + A ++ +
Sbjct: 867 KSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFV-----AFTNHFKQV 921
Query: 770 KEPMVARKQKLA---DSLRLQQLFRDVEDEETWIREKE-PIAASTNRGKDLIGVQNLLKK 825
+ AR+++L D+L + + TW+++ E ++ D ++ L +
Sbjct: 922 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 981
Query: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEG-HFAAEDVKAKLHELNQKWEALKAKASQRRQ 884
QALQ+ + + + ++ M ++ + +++ E+ +W+ L ++ + Q
Sbjct: 982 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1041
Query: 885 DLEDSLQAQQYFAD--------ANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALM 936
LE+ + + + E + +++E+ P +G ++ K + LK+ L+
Sbjct: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ------LKQCRLLV 1095
Query: 937 SDLSAYGSSIQALREQAQSCRQQVAP---TDDETGKELVLALYDY--QEKSPREVTMKKG 991
SD+ S+ ++ E Q + + P + ET + + +D+ Q+ R+ +K G
Sbjct: 1096 SDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGG 1155
Query: 992 DILTLLNSTNKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSA------SRENLLEEQG 1040
L S KD W + + Y K D Q A ++E +++
Sbjct: 1156 --LEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY-KTPDELQKAVEEMKRAKEEAQQKEA 1212
Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEEL---YHSL-LELGEKRKGMLEKSCKKFML 1096
+ L E +++ +L+ K++E L Y L L K K + E L
Sbjct: 1213 KVKLLTESVNSVIAQAPPVAQEALK-KELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1271
Query: 1097 FREANELQQWINEKEAAL-TSEEVGADLEQV-EVLQKKFDDFQKDLKANESRLKDINKVA 1154
+ +W+NE E L T+E + E++ EVL D + ++ +E I +A
Sbjct: 1272 LSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVL----DSLENLMRHSEDNPNQIRILA 1327
Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
+ L G+M E L+ + TFNS R
Sbjct: 1328 QTLTDGGVMDE-------------------------------LINEELETFNS------R 1350
Query: 1215 WRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRK 1274
WR L + A R +LL ++ + A ET++ S+ +Q
Sbjct: 1351 WRELHEEAVRRQKLL------EQSIQSAQETEK-------------------SLHLIQES 1385
Query: 1275 HEGFERDLAA-LGDKVNSLGETAE-RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRK 1332
++ LAA + DKV++ E + IQS S E E+ + NQ GK A QR
Sbjct: 1386 LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQ-----GKEAAQRV 1440
Query: 1333 AKLGD--SHDLQRFLSDFRDLMSWINGIRGLVSS----DELAKDVTGAEALLERHQEHRT 1386
D LQ FR N + L S DE+ + E + ++
Sbjct: 1441 LSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQS 1500
Query: 1387 EIDARAGTFQAFEQF----------GQQLLAHGHYASP-EIKQKLDILDQERADLEKAWV 1435
+++ +++ + G+Q++ +P E+ +++ L +L
Sbjct: 1501 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVT 1560
Query: 1436 QRRMMLDQCLEL-QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
+R+ L++CL+L + ++ W+AA + L K +++ + + + + KA
Sbjct: 1561 ERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT---KRSAVEGMPSNLDSEVAWGKAT 1617
Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGE----- 1549
+ EK + + G K + + V D+ L + I S+ E
Sbjct: 1618 QKEIEK---QKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLL 1674
Query: 1550 ---SQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHA 1606
+ ++ F ++VD I WI + T DES K K K + +AEL+
Sbjct: 1675 LEYQKHMETFDQNVDHITKWIIQ-ADTLLDESEK-------KKPQQKEDVLKRLKAELND 1726
Query: 1607 NADRIRGVIDM-GNSLIERGACAGSEDAVKARLAALADQWQFLVQ--KSAEKSQKLKEAN 1663
++ D N + RG V+ +++ L ++ + K+ + S LKE
Sbjct: 1727 IRPKVDSTRDQAANLMANRG--DHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKEL- 1783
Query: 1664 KQQNFNTGIKDFDFWLSEVEA------LLASEDYGKDLASVNNLLKKHQLLEADISAHED 1717
+ FN+ I+ L +EA L ED+ KD+ N E
Sbjct: 1784 --EQFNSDIQKL---LEPLEAEIQQGVNLKEEDFNKDMNEDN----------------EG 1822
Query: 1718 RLKDLNSQADSLM--TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAK-LNESHRLHQF 1774
+K+L + D+L + ++K K+ + + +K + + RR K L SH+ +Q+
Sbjct: 1823 TVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQY 1882
Query: 1775 FRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLR--KKHKRLEAELAAHEPAIQGVLDTG 1832
R DD LL +D + L + R +K K ++ EL + + V
Sbjct: 1883 KRQADD---------LLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1933
Query: 1833 KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWIN 1892
+ LS+D E Q Q + W+E++ A L + Q EE +
Sbjct: 1934 EGLSEDGAAMAVEPTQ--IQLSKRWREIESKFAQ-----FRRLNFAQIHTVREETMMVMT 1986
Query: 1893 EKMTLVASEDYGDTLAAI----QGLLKKHEAFETDFTVHKD-----RVNDVCTNGQDLIK 1943
E M L S L I Q LL+ + KD + + N +D ++
Sbjct: 1987 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2046
Query: 1944 KNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENS 2003
+++ + I SK K + L+ A + KL E + L F W EK N
Sbjct: 2047 QSSGRIDIIHSK------KTAALQSATPVERVKLQEALSQLDFQW----------EKVNK 2090
Query: 2004 LKTDDYGR-------------DLSSVQTLLTKQETFDAGLQAFQ--------------QE 2036
+ D GR D+ LT+ E F Q + Q+
Sbjct: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQD 2150
Query: 2037 GIA-------NITALKDQLL-AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQ 2088
GI + A ++++ + + ++ + SL RW ++ + RKK+L E
Sbjct: 2151 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQ- 2209
Query: 2089 SHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA 2148
+++ F + + F W E A+ + P+ +++K E L
Sbjct: 2210 ------KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLR 2263
Query: 2149 QADFNQLAELDRQIKSFRVASNPYTWFTMEALEE-------TWRNLQKIIKERELELQKE 2201
Q QL E + + S P + + LE W + + + E++ E++ +
Sbjct: 2264 QGILKQLNETGGPV----LVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQ 2319
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYL-------LDGSCMVEES--------GTL 2246
+ + +K ++ + N W+ R L +G V+E+ +
Sbjct: 2320 IKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDV 2379
Query: 2247 ESQLEATKRKHQEIRAMRSQLKKIEDLGA 2275
E L + ++E A + +K+EDL +
Sbjct: 2380 EEILSKGQHLYKEKPATQPVKRKLEDLSS 2408
Score = 157 bits (396), Expect = 2e-37
Identities = 438/2401 (18%), Positives = 922/2401 (38%), Gaps = 386/2401 (16%)
Query: 49 FQRDAEE---LEKWIQEKLQIASD---ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKL 102
+QR EE W+ EK + +KD + LQK +A+++ ++ KL
Sbjct: 561 WQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 620
Query: 103 DETGNLMISEGHFASETIRTR--LMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED 160
++S S T +T L R W+ L++K+ + ++ QA Q
Sbjct: 621 YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT 680
Query: 161 VMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQH 220
VM+ + VT+ E Q K QE+
Sbjct: 681 VMETVTT----VTTRE---------------------------------QILVKHAQEEL 703
Query: 221 PEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMAS 280
P K +Q V++ ++ R + D+ E SWI E ++ S
Sbjct: 704 PPPPPQKKRQITVDSEIRK-------------------RLDVDITELHSWITRSEAVLQS 744
Query: 281 DDFG--RDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ---SHPLSATQIQVK 335
+F R + L K +ER+ A K++ A L + + ++A I+
Sbjct: 745 PEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQA 804
Query: 336 REELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELA-SDVA 394
E+L + W + L +ER L + F + L T + + S+
Sbjct: 805 SEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 864
Query: 395 GAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
++ L ++ + + + AL G + + + + +
Sbjct: 865 AIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSD 924
Query: 455 LWELRRQQYEQCMDL--QLFYRDT-EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
+ + R ++ + D + Y++T + W+ + E L L S+ E + ++ +
Sbjct: 925 V-QAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQL--SVTDYEIMEQRLGE 981
Query: 512 FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA----LLSRRNALHERAMRRRA 567
+ S+ +E+ + L +T + + + A +++ + + + R L + +
Sbjct: 982 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1041
Query: 568 QLADSFH-LQQFFRDSDELKSWVNEKMKTATDE--AYKDPSNLQGKVQKHQAFEAELSAN 624
+L + + L++ LK W+ E +E A D L+ ++++ + +++
Sbjct: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTI 1101
Query: 625 QSRIDALEKAGQKLIDVNHYAKDEVAARMN----EVISLWKKLLEATELKGIKLREANQQ 680
Q ++++ + GQK + + A+ E A+R+ E+ + W + + + L+ ++
Sbjct: 1102 QPSLNSVNEGGQK---IKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1158
Query: 681 Q-QFNRNVEDIELWLYEVEG--------HLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
+++ ++ W+ + E + D+ K + ++ +++ EA V
Sbjct: 1159 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1218
Query: 732 DRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL-QQLF 790
+ ++ + QA E +KK+ E L Y+ L + + + L + +L
Sbjct: 1219 ESVNSVIAQAPPVAQ------EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELL 1272
Query: 791 RDVEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
+E W+ E E + + N + +L + L + +I+ + Q
Sbjct: 1273 SYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT--- 1329
Query: 850 MVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREK 909
+ +G E + +L N +W L +A +R++ LE S+Q+ Q + ++ ++E
Sbjct: 1330 -LTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQ---ETEKSLHLIQES 1385
Query: 910 EPIVGS--TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
+ Y D+ A + ++ + + SDL+++ S++ +++ Q +
Sbjct: 1386 LTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQG----------KE 1435
Query: 968 GKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQGFVPAAYVKKLDP 1026
+ VL+ D +K ++V+MK N + K+ +++ + +PA K ++
Sbjct: 1436 AAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQ 1495
Query: 1027 AQSASR----ENLLEEQGSIALRQEQIDN------QTRITKEAGSVSLRMKQVEELYHSL 1076
S+ NL + + E + Q + T+ + R+ ++ Y+ L
Sbjct: 1496 EVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNEL 1555
Query: 1077 LELGEKRKGMLEKSCKKFMLFR-EANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDD 1135
+RK LEK K R E N L +W+ + LT VE + D
Sbjct: 1556 GAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA------VEGMPSNLDS 1609
Query: 1136 -------FQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
QK+++ + LK I +V E L++ ++ + ET
Sbjct: 1610 EVAWGKATQKEIEKQKVHLKSITEVGEALKT------------------VLGKKET---- 1647
Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEE-RSQLLGSAHEVQRFHRDADETKE 1247
+ + LN W ++ AEE + LL ++ F ++ D +
Sbjct: 1648 --------------LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITK 1693
Query: 1248 WIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGD---KVNSLGETAERLIQSHP 1304
WI + + L D + + Q+K + +R A L D KV+S + A L+ +
Sbjct: 1694 WIIQADTLL-------DESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG 1746
Query: 1305 ESAEDLQE-KCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
+ L E + +ELN ++++ R KA + +L++F SD + L+ +
Sbjct: 1747 DHCRKLVEPQISELNHRFAAISHRIKTGKASI-PLKELEQFNSDIQKLLEPLEA------ 1799
Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GHYASPEIKQKLD 1421
E+ + V E + E GT + Q G L EIK K
Sbjct: 1800 --EIQQGVNLKEEDFNKDMNEDNE-----GTVKELLQRGDNLQQRITDERKREEIKIKQQ 1852
Query: 1422 ILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVE 1481
+L + L+ QRR L++ H+ W + +D LD +E
Sbjct: 1853 LLQTKHNALKDLRSQRRKKA-----LEISHQ-------WYQYKR---QADDLLKCLDDIE 1897
Query: 1482 ALI---------KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDR 1532
+ +K ++ D+ + ++E++ A++ A+ L G A + + ++ R
Sbjct: 1898 KKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDG--AAMAVEPTQIQLSKR 1955
Query: 1533 WRRLKAQMIE-KRSKLGESQTLQQFSRDV--DEIEAWIS--------------------E 1569
WR ++++ + +R + T+++ + V +++ IS E
Sbjct: 1956 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 2015
Query: 1570 KLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAG 1629
+L A D KD L + + + + L ++ RI +I + + A
Sbjct: 2016 QLLNAPDLCAKD-----FEDLFKQEESLKNIKDSLQQSSGRI-DIIHSKKTAALQSATPV 2069
Query: 1630 SEDAVKARLAALADQWQFLVQKSAEKSQKL-KEANKQQNFNTGIKDFDFWLSEVEALLAS 1688
++ L+ L QW+ + + ++ + + K + F+ IK F+ WL+E E L
Sbjct: 2070 ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK 2129
Query: 1689 EDYGKDL--ASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRD 1745
++ A LK+ L+ I + ++ LN+ + ++ SS D S +++K
Sbjct: 2130 TQIPENWEHAKYKWYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2186
Query: 1746 TINGRFQKIKSMAASRRAKLNESHR-LHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTG 1803
++N R+Q++ + R+ +L E L +F RD+++ W++E + + G++
Sbjct: 2187 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKE--- 2243
Query: 1804 VQNLRKKHKRLEAELAAHEPAIQGVL----DTGKKLSDDNTIGKEE---IQQRLAQFVEH 1856
Q L++K ++++ L P QG+L +TG + I EE ++ +L Q
Sbjct: 2244 -QQLKEKLEQVKL-LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2301
Query: 1857 W-KELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLK 1915
W K + L +G+ + + Q +E+ E +N + ++ +
Sbjct: 2302 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEG 2361
Query: 1916 KHEAFETDFTVHKDR--VNDVCTNGQDLIKKNNHHE------ENISSKMKGLNGKVSDLE 1967
+ ET+ V + V ++ + GQ L K+ + E++SS+ K +N + +L
Sbjct: 2362 PFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELR 2421
Query: 1968 ------------------------------KAAAQRKAKLD-----ENSAFLQFNWKADV 1992
K A K ++ E A FN
Sbjct: 2422 AKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTE 2481
Query: 1993 VESWIGEKENSLKTDDYG-RDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2051
+ W+ + +K+ DL + ++ KQ+ A +Q +Q L++ + AA
Sbjct: 2482 LTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK---ATMQDLEQRR----PQLEELITAA 2534
Query: 2052 KHVQSKA--------IEARHASLMKRWSQLLANSAARKKKLLE----AQSHFRKVEDLFL 2099
+++++K I R + +W ++ + R+++L E + E+
Sbjct: 2535 QNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQ 2594
Query: 2100 TFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELD 2159
+ + SW E D ++ + E K L + +++++ A N LA
Sbjct: 2595 VLGQARAKLESWKEGPYT--VDAIQ-KKITETKQLAKDLRQWQTNVDVA----NDLAL-- 2645
Query: 2160 RQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHA 2219
+ ++ + E + +WR++ K + ERE L EE +L Q+F
Sbjct: 2646 KLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAAL-------EETHRLLQQFPLDL 2698
Query: 2220 NAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKH--QEIRAMRSQLKKIEDLGAAM 2277
F W+ E T T +AT+++ ++ + ++ +K+ +DL +
Sbjct: 2699 EKFLAWLTEAET-------------TANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2745
Query: 2278 E 2278
E
Sbjct: 2746 E 2746
Score = 116 bits (291), Expect = 2e-25
Identities = 398/2188 (18%), Positives = 823/2188 (37%), Gaps = 388/2188 (17%)
Query: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINAD-ELASDVAGAEALLDRHQEHKGEIDAHED 415
+ L R+ ++ SW+ + + A E+++DV + H+ + ++ AH+
Sbjct: 335 MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQG 394
Query: 416 SFKSADESGQALLAAGHYASDE---VREKLTVLSEERAAL-LELWELRRQQYEQCMDLQL 471
+ + G L+ G + DE V+E++ +L+ L + E + + MDLQ
Sbjct: 395 RVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ- 453
Query: 472 FYRDTEQVDNWMSKQEAF---LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528
+ +++++W++K E + E LG L+ ++ +++H+ ++ L ++ ++ +L
Sbjct: 454 -NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTH 512
Query: 529 FATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHL--QQFFRDSDELK 586
+ +++ + +L R A R R L L Q+ +
Sbjct: 513 MVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572
Query: 587 SWVNEKMKTATD---EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNH 643
+W++EK +KD + + +QK +A+L EK Q
Sbjct: 573 AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADL----------EKKKQS------ 616
Query: 644 YAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLAS 703
M ++ SL + LL + K + + E WL
Sbjct: 617 ---------MGKLYSLKQDLLSTLKNKSV--------------TQKTEAWL--------- 644
Query: 704 DDYGKDLTN-VQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEAL 762
D++ + N VQ L+K A + V Q + T+ + +++ L
Sbjct: 645 DNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET---------VTTVTTREQIL 695
Query: 763 V--ARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG--KDLIG 818
V A+ E P ++Q DS ++L D+ + +WI E + S +
Sbjct: 696 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGN 755
Query: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE---GHFAAEDVKAKLHELNQKWEAL 875
+L +K A++ E A +++ ++ A+VE+ A+ +K +LN +W
Sbjct: 756 FSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEF 815
Query: 876 KAKASQRRQDLEDSL-------QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEAL 928
S+R LE Q QQ AE+W++ +P S + + ++
Sbjct: 816 CQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI-QPTTPS-----EPTAIKSQ 869
Query: 929 LKKHEALMSDLSAYGSSIQALREQAQSCRQQ-VAPTDDETGKELVLALYDYQEKSPREVT 987
LK + ++ LS I+ L+ Q+ + +++ P + +A ++ ++ +V
Sbjct: 870 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDAD---FVAFTNHFKQVFSDVQ 926
Query: 988 MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQ-GSIALRQ 1046
++ ++ T+ ++ ++ ++ + +V + K P S + ++E++ G + Q
Sbjct: 927 AREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQ 986
Query: 1047 EQIDNQT-----------RITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
+ Q ++K+A S R Q E + + +K L + C+K
Sbjct: 987 SSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSE--FEEIEGRWKKLSSQLVEHCQK-- 1042
Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAE 1155
L + N+L++ N ++ L+K + LK L D + +
Sbjct: 1043 LEEQMNKLRKIQNH----------------IQTLKKWMAEVDVFLKEEWPALGDSEILKK 1086
Query: 1156 DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERW 1215
L+ L+ ++Q +Q + + + A P ++RL +KELN +W
Sbjct: 1087 QLKQCRLLVSDIQTIQPS-LNSVNEGGQKIKNEAEPEFASRLETE-------LKELNTQW 1138
Query: 1216 RSL-QQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA-----SVQ 1269
+ QQ+ + L G + +D E EW+ + + ++ + +V+
Sbjct: 1139 DHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVE 1198
Query: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAED-------------------L 1310
++R E ++ A KV L E+ +I P A++ L
Sbjct: 1199 EMKRAKEEAQQKEA----KVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRL 1254
Query: 1311 QEKCTELNQAWS----------SLGKRADQRKAKL-------GDSHDLQRFLSDFRDLMS 1353
KC L + W+ K ++ + KL G + ++ L +LM
Sbjct: 1255 NGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMR 1314
Query: 1354 WI----NGIRGLVSS----------------------DELAKDVTGAEALLERH------ 1381
N IR L + EL ++ + LLE+
Sbjct: 1315 HSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQE 1374
Query: 1382 --------QEHRTEIDARAGTF-----------QAFEQFGQQLLAHGHYASPEIKQKLDI 1422
QE T ID + + Q ++ L +H + E+K+
Sbjct: 1375 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSH-EISLEEMKKHNQG 1433
Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDC--EQA--ENWMAAREAFLNT---EDKGD 1475
+ + L + V ++ + D ++ +LF + EQ E+ M E ++ E K
Sbjct: 1434 KEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSV 1493
Query: 1476 SLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG-DISSRRNEVLDRWR 1534
+ V++ + + K+++ + ++ + Q++ ++ R + +
Sbjct: 1494 EQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYN 1553
Query: 1535 RLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
L A++ E++ +L + L ++ ++++ + W++ T + + + S L S+
Sbjct: 1554 ELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAA---TDMELTKRSAVEGMPSNLDSE 1610
Query: 1594 HQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSA 1653
+A + E+ ++ + ++G +L + E V+ +L+ L W + ++
Sbjct: 1611 VAWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAE 1668
Query: 1654 EKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI 1712
E L E K + F+ + W+ + + LL E K ++LK+ L+A++
Sbjct: 1669 EWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-DESEKKKPQQKEDVLKR---LKAEL 1724
Query: 1713 SAHEDRLKDLNSQADSLMTSSAFDTSQ-VKDKRDTINGRFQKIKSMAASRRAKLNESHRL 1771
+ ++ QA +LM + + V+ + +N RF I + +A + L
Sbjct: 1725 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASI-PLKEL 1783
Query: 1772 HQFFRD----MDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
QF D ++ E+ I++ L ED+ +D+ +E ++
Sbjct: 1784 EQFNSDIQKLLEPLEAEIQQGVNLK-EEDFNKDMN----------------EDNEGTVKE 1826
Query: 1828 VLDTG----KKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQR-LEESLEYQQFVA 1882
+L G ++++D+ + +I+Q+L Q +H LK L + R ++ LE S ++ Q+
Sbjct: 1827 LLQRGDNLQQRITDERKREEIKIKQQLLQ-TKH-NALKDLRSQRRKKALEISHQWYQYKR 1884
Query: 1883 NVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLI 1942
++ L +D LA++ + + E D + K + + +
Sbjct: 1885 QADD---------LLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKK---------EEL 1926
Query: 1943 KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWKADVVESWIGEKE 2001
E +S +G +E Q + E S F QF + E+
Sbjct: 1927 NAVRRQAEGLSE-----DGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREET 1981
Query: 2002 NSLKTDDYGRDLSSV------------QTLLTKQETFDAG-------LQAFQQEGIANIT 2042
+ T+D ++S V Q LL ++ +A F+QE ++
Sbjct: 1982 MMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE--ESLK 2039
Query: 2043 ALKDQLLAAKH----VQSK-------AIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
+KD L + + SK A L + SQL K + Q F
Sbjct: 2040 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 2099
Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA---LREAHDAF------- 2141
+ + + F FN W AE+ L + E K L+E D
Sbjct: 2100 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVV 2159
Query: 2142 RSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKE 2201
R+ ++ + Q ++ D I ++ S W Q++ K+ L
Sbjct: 2160 RTLNATGEEIIQQSSKTDASILQEKLGSLNLRW-------------QEVCKQ----LSDR 2202
Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVE--ESGTLESQLEATKRKHQE 2259
++R EE + EF + N F W++E S +E + L+ +LE K +E
Sbjct: 2203 KKRLEEQKNILSEFQRDLNEFVLWLEEADNI---ASIPLEPGKEQQLKEKLEQVKLLVEE 2259
Query: 2260 IRAMRSQLKKIEDLGAAM--------EEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQH 2311
+ + LK++ + G + EE L+NK + + QW ++ + Q
Sbjct: 2260 LPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNL-----QWIKVSRALPEKQG 2314
Query: 2312 NLEQQIQARNTTGVTEEALKEFSMMFKH 2339
+E QI+ G E+ L++ H
Sbjct: 2315 EIEAQIK---DLGQLEKKLEDLEEQLNH 2339
Score = 109 bits (272), Expect = 4e-23
Identities = 195/995 (19%), Positives = 413/995 (41%), Gaps = 111/995 (11%)
Query: 13 EDIQERRQQVLDRYHRFKELSTLRRQK-LEDSYRFQFFQRDAEELEKWIQE-KLQIASDE 70
E+I+ ++Q + +++ K+L + RR+K LE S+++ ++R A++L K + + + ++AS
Sbjct: 1845 EEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1904
Query: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS-----ETIRTRLM 125
+D ++ ++ Q + E+ A L E G M E I ++
Sbjct: 1905 EPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFA 1964
Query: 126 ELHRQWELLLEKMREKGIKLLQAQKLVQ-------YLRECEDVMDWINDKEAIVTSEEL- 177
+ R + +RE+ + ++ ++ YL E V + + E ++ + +L
Sbjct: 1965 QFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLC 2024
Query: 178 GQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAA 236
+D E + ++ + + + R++ ++ +Q P E + ++ +++
Sbjct: 2025 AKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQ 2084
Query: 237 WQRLKGLALQRQGKLFGAAEV-QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLR 295
W+++ + RQG+ + E +RF+ D+ W+ E EQ + + +
Sbjct: 2085 WEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWY 2144
Query: 296 KHEGLERDLAALEDKVKALCAEADR-LQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354
E L+ + + V+ L A + +QQS A+ +Q K L W+++ ++R
Sbjct: 2145 LKE-LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2203
Query: 355 ARLNDSYRLQRFLADF-RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHK---GEI 410
RL + + L++F RDL +V ++ N + + + L ++ ++ K E+
Sbjct: 2204 KRLEEQ---KNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEEL 2260
Query: 411 DAHEDSFKSADESGQALLAAGHYA---SDEVREKLTVLS---------------EERAAL 452
+ K +E+G +L + + D++ KL + E A +
Sbjct: 2261 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2320
Query: 453 LELWELRRQ---QYEQCMDLQLF---YRDTEQVDNWMSKQEAFLLNED---LGDSLDSVE 503
+L +L ++ EQ L L+ R+ ++ N +++ F + E + VE
Sbjct: 2321 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2380
Query: 504 ALLKKHEDFEKSLSAQEEKITALDEFAT------KLIQNNHYAMEDVA----------TR 547
+L K + K A + L++ ++ +L+Q D+A T+
Sbjct: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2440
Query: 548 RDALLSRRNALHERAMRRRAQLADSFHLQ-----QFFRDSDELKSWVN--EKMKTATDEA 600
L+++ E A+ + ++ S L+ F R EL W++ +++ +
Sbjct: 2441 TVTLVTQPVVTKETAI-SKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2499
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLID--VNHYAKDEVAARMNEVIS 658
D ++ + K +A +L + +++ L A Q L + N A+ + R+ + +
Sbjct: 2500 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2559
Query: 659 LWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVE--------GHLASDDYGKDL 710
W ++ E + N++QQ N ++D WL E + + +
Sbjct: 2560 QWDEVQEHLQ---------NRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2610
Query: 711 TNVQNLQKK---HALLEADVAAHQDRID-GITIQARQFQDAGHFDAENIKKKQEALVARY 766
V +QKK L D+ Q +D + + +D D + E + A +
Sbjct: 2611 YTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASW 2670
Query: 767 EALKEPMVARKQKLADSLRLQQLF-RDVEDEETWIREKEPIA----ASTNRGK---DLIG 818
++ + + R+ L ++ RL Q F D+E W+ E E A +T + + D G
Sbjct: 2671 RSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKG 2730
Query: 819 VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE--EGHFAAEDVKAKLHELNQKWEALK 876
V+ L+K+ Q LQ EI H + + ++ EG A ++ +L +N KW L+
Sbjct: 2731 VKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELR 2790
Query: 877 AKASQRRQDLE-DSLQAQQYFADANEAESWMREKE 910
K+ R LE S Q ++ E W++ K+
Sbjct: 2791 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKD 2825
Score = 100 bits (248), Expect = 2e-20
Identities = 181/943 (19%), Positives = 381/943 (40%), Gaps = 133/943 (14%)
Query: 30 KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD--ENYKDPTNLQGKLQKHQA 87
K+LS +++ E FQRD E W++E IAS E K+ L+ KL++ +
Sbjct: 2197 KQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ-QLKEKLEQVKL 2255
Query: 88 FEAEVQANSGAIVKLDETGNLMISEGHFASET---IRTRLMELHRQWELLLEKMREKGIK 144
E+ G + +L+ETG ++ + E + +L + + QW + + EK +
Sbjct: 2256 LVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGE 2315
Query: 145 L-LQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
+ Q + L Q ++ ED+ E+L L + ++ + E +
Sbjct: 2316 IEAQIKDLGQLEKKLEDL------------EEQLNHLLLWLSPIRNQLEIY--------- 2354
Query: 204 RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
N+ NQ +QE E ++ KQ +V + + L ++ Q R
Sbjct: 2355 --NQPNQEGPFDVQET---EIAVQAKQPDVEEILSKGQHLYKEKPA-------TQPVKRK 2402
Query: 264 VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
++ D + +V LL++ + DLA + A + L
Sbjct: 2403 LE----------------DLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTL-- 2444
Query: 324 SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFR----DLTSWVTE 379
TQ V +E I+ E +L E A LADF +LT W++
Sbjct: 2445 -----VTQPVVTKETAISKLEMPSSLMLEVPA-----------LADFNRAWTELTDWLSL 2488
Query: 380 MKALINADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASD 436
+ +I + + D+ ++ + + +++ + + Q L + A
Sbjct: 2489 LDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEART 2548
Query: 437 EVREKLTVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLLNEDL 495
+ +++ + + + E + RRQQ + + D + E+ + + + A L +
Sbjct: 2549 IITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKE 2608
Query: 496 GD-SLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSR 554
G ++D+++ + + + K L + + ++ A KL+++ Y+ +D TR+ +++
Sbjct: 2609 GPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRD--YSADD--TRKVHMITE 2664
Query: 555 R-----NALHERAMRRRAQLADSFHL-QQFFRDSDELKSWVNEKMKTAT--------DEA 600
++H+R R A L ++ L QQF D ++ +W+ E TA +
Sbjct: 2665 NINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERL 2724
Query: 601 YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA--RMNEVIS 658
+D ++ +++ Q + E+ A+ L++ QK++ + D V R++ +
Sbjct: 2725 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2784
Query: 659 LWKKLLEAT-ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNL 716
W +L + + ++ ++Q ++ + +++++ +WL + L+ G D VQ
Sbjct: 2785 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQ 2844
Query: 717 QKKHALLEADVAAHQDRIDGITIQARQFQDAGHFD-----------------AENI---- 755
H + ++ + I R F + A+N+
Sbjct: 2845 NDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLL 2904
Query: 756 KKKQEALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGK 814
+K+ E + +E L ++K+ ++L RLQ+L ++ + +R+ E I S
Sbjct: 2905 RKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVG 2964
Query: 815 DLI--GVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKW 872
DL+ +Q+ L+K +AL+ EIA + + V + G + + L +LN +W
Sbjct: 2965 DLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRW 3024
Query: 873 EALKAKASQRRQDLEDSLQ----AQQYFADANEAESWMREKEP 911
+ L+ R + L ++ + A Q+F + W R P
Sbjct: 3025 KLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISP 3067
>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
[Homo sapiens]
Length = 3321
Score = 170 bits (431), Expect = 1e-41
Identities = 411/2139 (19%), Positives = 855/2139 (39%), Gaps = 251/2139 (11%)
Query: 290 VQALLRKHEGL-ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRT 348
++A+ + +GL E D +E K + D+LQ P + Q K +++ ++++
Sbjct: 1047 IEAIQQAEDGLKEFDAGIIELKRRG-----DKLQVEQP--SMQELSKLQDM---YDELMM 1096
Query: 349 LAAERHARLNDSYRL----QRFLADFRDLTSWVTEMKALINADE--LASDVAGAEALLDR 402
+ R + LN + L +R L D DL E A D+ + S + LLD+
Sbjct: 1097 IIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMA---GDQKIIVSSKEEIQQLLDK 1153
Query: 403 HQEHKGEIDAH----EDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWEL 458
H+E+ +++H E F+ A+ + ++ + + VL +EL +
Sbjct: 1154 HKEYFQGLESHMILTETLFRKIISF--AVQKETQFHTELMAQASAVLKRAHKRGVELEYI 1211
Query: 459 RRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSA 518
D Q R E V++ S L+ E+ +D + ++ + SL+
Sbjct: 1212 LETWSHLDEDQQELSRQLEVVES--SIPSVGLVEENEDRLIDRITL----YQHLKSSLNE 1265
Query: 519 QEEKI-TALDEFATKLIQNNHYAMEDVATRR-DALLSRRNALHERAMRRRAQLADSFHLQ 576
+ K+ LD+ LI + +E + + LS N + + R L H
Sbjct: 1266 YQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILK---HWT 1322
Query: 577 QFFRDSDELKSWVN---EKMKTATDEAYKDPSNLQGKVQKHQ----AFEAELSANQSRID 629
++ +S +L W+ ++++ T ++ P L+ V+ H F E+ A S
Sbjct: 1323 RYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE-MVRDHLNAFLEFSKEVDAQSSLKS 1381
Query: 630 ALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN-VE 688
++ G +L+ + + + ++ + S W LL KL + + +R+ +
Sbjct: 1382 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 1441
Query: 689 DIELWLYEVEGHLASDDYGKDLTN------VQNLQKKHALLEADVAAHQDRIDGITIQAR 742
++ W+ +E + D+ ++ N + +K+ + D+ Q +D +
Sbjct: 1442 EVMSWISLMENVIQKDE--DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVL 1499
Query: 743 QFQ----DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL--RLQQLFRDVEDE 796
Q ++ D + ++ A+ ++ L + +V K +L + L + +V+
Sbjct: 1500 QISSQDVESKRSDKTDFAEQLGAMNKSWQIL-QGLVTEKIQLLEGLLESWSEYENNVQCL 1558
Query: 797 ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGH 855
+TW +E +R D VQN LK Q L+ I E ++ + Q G A+++ +
Sbjct: 1559 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKE 1618
Query: 856 FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESWMREK----- 909
+ V + L EL Q W L Q + L+ L Q + ++ S++ E
Sbjct: 1619 DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 1678
Query: 910 --EPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDE 966
+ GS + + + D+ + L E L +GS L ++ C V T
Sbjct: 1679 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKE---CHPPVTETLTN 1735
Query: 967 TGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDP 1026
T KE+ + + E+ ++ K L L KD+ K + Q
Sbjct: 1736 TLKEVNMRWNNLLEEIAEQLQSSKA--LLQLWQRYKDYSKQCASTVQ------------- 1780
Query: 1027 AQSASRENLLEEQGSIALRQEQIDNQTRI-TKEAGSVSLRMKQVEELYHSLLELGEKRKG 1085
+E+ E A ++ D++ ++ + + V++ L ELGE+ K
Sbjct: 1781 ----QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 1836
Query: 1086 MLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANES 1145
++ S + + L Q + E AL ++ Q VL ++ F K L+A E+
Sbjct: 1837 QVDASAAS-AIQSDQLSLSQHLCALEQALCKQQTSL---QAGVLD--YETFAKSLEALEA 1890
Query: 1146 RLKDINKVAEDLESEGLMAEEVQAVQQ--QEVYGMMPRDETDSKTASPWKSA--RLMVHT 1201
+ + ++ + + + ++ +Q+ +E+ G M + + + RL ++
Sbjct: 1891 WIVEAEEILQGQDPS--HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLND 1948
Query: 1202 VATFNSIKELNERWRSLQQLAEER-SQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD- 1259
++ LN W + ER S+L + Q F + E++ + Q L +
Sbjct: 1949 -KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 2007
Query: 1260 --NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTE 1316
NY H L QR HE F+ ++ + ++S+ +RL+ Q + ++ K T
Sbjct: 2008 SGNYQHLLEQ----QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTL 2063
Query: 1317 LNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIRGLVSS--DELAKDVTG 1373
L+ W + +RA QR+ + QR+ L W+ + L S + +
Sbjct: 2064 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 2123
Query: 1374 AEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKA 1433
A L + Q + G++ + G+QLL + L E A++++
Sbjct: 2124 ARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA------ALQAELAEIQEK 2177
Query: 1434 WVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK------GDSLDSVEALIKK 1486
W M L +Q +L +D E+ E +A L T K D + + A +
Sbjct: 2178 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMR 2237
Query: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDIS--SRRNEVLDR-WRRLKAQMIEK 1543
++ + A+ + + L D L A + + DIS + R E+L R W L Q+ +
Sbjct: 2238 CKELENAVGSWTDDLTQLSLLKDTLSA--YISADDISILNERVELLQRQWEELCHQLSLR 2295
Query: 1544 RSKLGES-QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEA 1602
R ++GE FS E+ W+++ S +I + +++ K +K E
Sbjct: 2296 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG-----DILIEEMIEKLKKDYQEEI 2350
Query: 1603 ELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA 1662
+ A ++I+ + MG L + + ++ +L + D+WQ L+ A + +KLKE
Sbjct: 2351 AI-AQENKIQ-LQQMGERL-AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET 2407
Query: 1663 -NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLAS--VNNLLKKHQLLEADISAHEDRL 1719
Q + + WL+ +E+ LA S + L + Q L+ DI H +
Sbjct: 2408 LVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGV 2467
Query: 1720 KDLNSQADSLM-----TSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ- 1773
+ + + L+ ++ + ++ ++ R++ I +M+ RR K+ E+ RL Q
Sbjct: 2468 ASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQK 2527
Query: 1774 FFRDMDDEESWIK-EKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTG 1832
F D E W+K ++ G T + KK + + ++ ++ +
Sbjct: 2528 FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQY 2587
Query: 1833 KKLSDDN-TIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESL-EYQQFVANVEEEEAW 1890
++L+ +N T ++Q + + + W L++ + +RL+ + + ++F + W
Sbjct: 2588 RRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVW 2647
Query: 1891 INE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKN---- 1945
+ E + L E + + +Q +K+ +AF+ + +++ +++ + G+ LI+K+
Sbjct: 2648 LTEMDLQLTNIEHFSE--CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLD 2705
Query: 1946 -----------NHHEENISSKMKGLNGK-----VSDLEKAAAQRKAKLDENSAFLQFNWK 1989
+ + + +++ + K + D E + R+ +L++++A +W
Sbjct: 2706 AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWH 2765
Query: 1990 ADVVESWIGEKENS---------LKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2040
+S + + +S L+++ GRD + + + D L + ++
Sbjct: 2766 DRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR 2825
Query: 2041 ITALKDQLLAAKHVQSKAIEARHA-SLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFL 2099
+D+ + K R A L S L + K L +++ ++ E++
Sbjct: 2826 ALPSEDE----EGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 2881
Query: 2100 TFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELD 2159
+ ++ ++ +K L E SS+ S + ++L E +
Sbjct: 2882 SKTPTGPELDTSYKG---------------YMKLLGEC----SSSIDSVKRLEHKLKEEE 2922
Query: 2160 RQIKSFRVASNPYTWFTMEA-LEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQH 2218
+ F N ++ T A + + W LQ +EL R ++N + Q+F
Sbjct: 2923 ESLPGF---VNLHSTETQTAGVIDRWELLQAQALSKEL-------RMKQNLQKWQQFNSD 2972
Query: 2219 ANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKH--QEIRAMRSQLKKIEDLGAA 2276
N+ W+ +T E +LE +R +I+ + Q+KK+++L A
Sbjct: 2973 LNSIWAWLGDT-----------------EEELEQLQRLELSTDIQTIELQIKKLKELQKA 3015
Query: 2277 ME--EALIL-----DNKYTEHSTVGLAQQWDQLDQLGMR 2308
++ +A+IL ++T+ + D+L Q+ R
Sbjct: 3016 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGR 3054
Score = 165 bits (418), Expect = 5e-40
Identities = 365/1871 (19%), Positives = 736/1871 (39%), Gaps = 253/1871 (13%)
Query: 49 FQRDAEELEKWIQ---EKLQIASDENYKDPTNLQ---GKLQKHQAFEAEVQANSGAIVKL 102
+Q ++ +L W+Q ++L+ + ++ P L+ L F EV A S +
Sbjct: 1324 YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV 1383
Query: 103 DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKL--LQAQKLVQYLRECED 160
TGN ++ + T+R+ L + QW LL + KL LQ KL +
Sbjct: 1384 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPS-RHAISE 1442
Query: 161 VMDWINDKEAIVTSEE------LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAK 214
VM WI+ E ++ +E +G H E LQ K++ F+ D+ + V+ VNQ +
Sbjct: 1443 VMSWISLMENVIQKDEDNIKNSIGYKAIH-EYLQ-KYKGFKIDINCKQLTVDFVNQSVLQ 1500
Query: 215 LIQEQHPEEELIKTKQDE----VNAAWQRLKGLALQRQGKLFGAAEV-QRFNRDVDETIS 269
+ + + KT E +N +WQ L+GL ++ L G E + +V +
Sbjct: 1501 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 1560
Query: 270 WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSA 329
W + +E+ + D ASVQ L +D LED +KA E ++++Q+
Sbjct: 1561 WFETQEKRLKQQHRIGDQASVQNAL-------KDCQDLEDLIKAKEKEVEKIEQN---GL 1610
Query: 330 TQIQVKRE-----------ELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWV 377
IQ K+E EL W + + + L + F + S++
Sbjct: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL 1670
Query: 378 TEMK-ALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH---- 432
E + +L L + + +D Q + +++ E S + LL H
Sbjct: 1671 MEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVT 1730
Query: 433 ----YASDEVREKLTVLSEERA-------ALLELWELRRQQYEQCMDLQLFYRDTEQVDN 481
EV + L EE A ALL+LW+ + +QC +Q ++
Sbjct: 1731 ETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAS------TVQQQED 1784
Query: 482 WMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN-NHYA 540
++ N+D+ D D V ++ D K L ++ + L E +L Q + A
Sbjct: 1785 RTNELLKAATNKDIAD--DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 1842
Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQL-ADSFHLQQFFRDSDELKSWV--NEKMKTAT 597
+ + + +L AL + +++ L A + F + + L++W+ E++
Sbjct: 1843 ASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
Query: 598 DEAY-KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEV 656
D ++ D S +Q ++++ + + S+ +D L + G +L D+ RM +
Sbjct: 1903 DPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-----PLNDKEIKRMQNL 1957
Query: 657 ISLWKKLLEATELKGIKLRE-ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQN 715
W + T + KL+ Q Q F E +L + E LA + G N Q+
Sbjct: 1958 NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG----NYQH 2013
Query: 716 L---QKKHALLEADVAAHQDRIDGITIQARQFQDAGHF-DAENIKKKQEALVARYEALKE 771
L Q+ H L +A++ + Q + I I ++ + G D + K L +++ +
Sbjct: 2014 LLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIR 2073
Query: 772 PMVARKQKLADSLRLQQLFRDVEDE-ETWIREKE--PIAASTNRGKDLIGVQNLLKKHQA 828
R+ + +R Q +R++ ++ W+ E P++ + L + L + Q
Sbjct: 2074 RAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQF 2133
Query: 829 LQAEIAGHEPRIKAVTQKGNAMVEEGHFAAE-DVKAKLHELNQKWEALKAKASQRRQD-- 885
+ + + G ++ AE ++A+L E+ +KW++ + ++++
Sbjct: 2134 KEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLA 2193
Query: 886 --LEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYG 943
L+D + ++ AD+ E ++K + S +E AE + K L + + ++
Sbjct: 2194 FLLKDWEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQMRCKE--LENAVGSWT 2249
Query: 944 SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKD 1003
+ L + ++ D E V L E+ ++++++ I LN +
Sbjct: 2250 DDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN----E 2305
Query: 1004 WWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEE---------QGSIALRQE-QIDNQ- 1052
W +++ ++ +++ S + + L+EE Q IA+ QE +I Q
Sbjct: 2306 WAVFSEKNKE---LCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQ 2362
Query: 1053 --TRITK-----EAGSVSLRMKQVEELYHSLLELGEKR-KGMLEKSCKKFMLFREANELQ 1104
R+ K +A + ++ +V + + LL+L R K + E L + + L+
Sbjct: 2363 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 2422
Query: 1105 QWINEKEAALTSEEV--GADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGL 1162
W+ E+ L V + E+++ + + Q+D++ + + + + + E +
Sbjct: 2423 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE------V 2476
Query: 1163 MAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLA 1222
+ + A TD++ S ++ R L+ RWR++ ++
Sbjct: 2477 LLHDCDAC------------ATDAECDSIQQATR-------------NLDRRWRNICAMS 2511
Query: 1223 EERSQLLGSAHEV-QRFHRDADETKEWIEEKNQ-ALNTDNYGHDLASVQALQRKHEGFER 1280
ER + + Q+F D ++W++ + A + G + +K E F+R
Sbjct: 2512 MERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQR 2571
Query: 1281 DLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSH 1339
+ ++ + + RL ++ +SA L++ E NQ W +L KR +
Sbjct: 2572 QVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR----- 2626
Query: 1340 DLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFE 1399
L+ F+ + + + I LV E+ +T E E ++ A+ +AF
Sbjct: 2627 -LKHFIGQREEFETARDSI--LVWLTEMDLQLTNIEHFSE------CDVQAKIKQLKAF- 2676
Query: 1400 QFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN 1459
QQ ++ H +I + + L ++ L+ A ++ EL R C+
Sbjct: 2677 ---QQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEE--------ELDELRRYCQ---- 2721
Query: 1460 WMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAK 1519
E F E L + +H+ D+ + +++ AAL +A
Sbjct: 2722 -----EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDS--AALSDLHWHDRSADSLLS 2774
Query: 1520 GDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVD---EIEAWISEKLQTASD 1576
SS N L + L+++ + + ++ D D ++E+ +S L + D
Sbjct: 2775 PQPSS--NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRAL-PSED 2831
Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEA---ELHANADRIRGVIDMGNSLIER--------- 1624
E +D + L + H A E+ +L D R I ++I
Sbjct: 2832 EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELD 2891
Query: 1625 ----------GACAGSEDAVK-----------------------ARLAALADQWQFLVQK 1651
G C+ S D+VK + A + D+W+ L +
Sbjct: 2892 TSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQ 2951
Query: 1652 SAEKSQKLKE-ANKQQNFNTGIKDFDFWLSEVE---ALLASEDYGKDLASVNNLLKKHQL 1707
+ K ++K+ K Q FN+ + WL + E L + D+ ++ +KK +
Sbjct: 2952 ALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKE 3011
Query: 1708 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE 1767
L+ + + + +N + + + ++ ++D+ +NGR+ ++ S+ R L +
Sbjct: 3012 LQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQD 3071
Query: 1768 SHRLHQFFRDM 1778
+ Q F +M
Sbjct: 3072 ALMQCQGFHEM 3082
Score = 151 bits (381), Expect = 9e-36
Identities = 487/2443 (19%), Positives = 948/2443 (38%), Gaps = 349/2443 (14%)
Query: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
++PS L + E + V+ R + R+QK +DS Q E +E +
Sbjct: 453 LEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDS--LQSISTKMEAIELKL 510
Query: 61 QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDET-GNLMISEGHFA--- 116
E S E + P + ++ +HQA E+ I +L + ++SE A
Sbjct: 511 SE-----SPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPA 562
Query: 117 ------------SETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDW 164
+E + T M+ + +LL EK+ ++ + Q Q L +Y E +++ W
Sbjct: 563 EQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSW 622
Query: 165 INDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE 224
+ +A + + L E ++ ++ + + Q + E++V +++ + H E
Sbjct: 623 LLSTKATLDT-ALSPPKEPMD-MEAQLMDCQNMLVEIEQKVVALSELSV------HNENL 674
Query: 225 LI------KTKQDEVNAAWQRLKG--LALQR-----QGKLFGAAEVQRFNRDVDETISWI 271
L+ K + +++ +RLKG L LQR Q + G A+ ++ DVD T +
Sbjct: 675 LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ-EKEESDVDLTATQS 733
Query: 272 KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ 331
++ +A Q+ L++ + LE++LA + ++++ + + + H + T
Sbjct: 734 PGVQEWLAQAR-TTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETS 792
Query: 332 IQVKREELITNWE---QIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
+ + + E + +AE R+ Q F T+ K L N E
Sbjct: 793 GDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEF----------STKQKLLQNVLE 842
Query: 389 LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAG-HYASDEVREKLTVLSE 447
+ + L R + ++ + D+S L G + A +EV S+
Sbjct: 843 QEQE----QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS------SQ 892
Query: 448 ERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLK 507
A + L ++ Y+ + D E+ LL E+ L + E L K
Sbjct: 893 SGGAKRQSIHLEQKLYDGVSATSTWLDDVEE----RLFVATALLPEETETCLFNQEILAK 948
Query: 508 KHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRA 567
K +S + +K L A +N +ED LL R + L +R
Sbjct: 949 D----IKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTL---GCLLGRLSLLDSVVNQRCH 1001
Query: 568 QLADSFHLQQFFRDSDELK----SWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSA 623
Q+ + LQQ ++LK S + K A + +++ Q E L
Sbjct: 1002 QMKE--RLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKE 1059
Query: 624 NQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQ---- 679
+ I L++ G KL M E+ L E + G + NQ
Sbjct: 1060 FDAGIIELKRRGDKL--------QVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTL 1111
Query: 680 QQQFNRNVEDIELWLYEVEGHLASDD--YGKDLTNVQNLQKKHALLEADVAAHQDRIDGI 737
+ Q+ R ++D+ L + +A D +Q L KH + +H +
Sbjct: 1112 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH------M 1165
Query: 738 TIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL--------QQL 789
+ F+ F + + L+A+ A+ + R +L L Q+L
Sbjct: 1166 ILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQEL 1225
Query: 790 FRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
R +E E+ I + + +R D I + +Q L++ + ++P++ V G
Sbjct: 1226 SRQLEVVESSIPSVGLVEENEDRLIDRITL------YQHLKSSLNEYQPKLYQVLDDGKR 1279
Query: 850 MVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQA-QQYFADANEAESWMRE 908
++ + D++++L++L + W + K S+ LE L+ +Y +++ + W++
Sbjct: 1280 LLIS--ISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQS 1337
Query: 909 KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD--E 966
+D E ++ + +L + A E ++ Q +
Sbjct: 1338 A------------KDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLS 1385
Query: 967 TGKELVLALYDYQEKSPREVTMKKGDILTL---LNSTNKDWWKVEVNDRQGFVPAAYVK- 1022
TG +L + +KK D TL L+ + W + N +PA K
Sbjct: 1386 TGNQL--------------LRLKKVDTATLRSELSRIDSQWTDLLTN-----IPAVQEKL 1426
Query: 1023 -KLDPAQSASRENLLEEQGSIALRQEQID-NQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
+L + SR + E I+L + I ++ I G Y ++ E
Sbjct: 1427 HQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG------------YKAIHEYL 1474
Query: 1081 EKRKGM-LEKSCKKFML-FREANELQ---QWINEKEAALT--SEEVGA------------ 1121
+K KG ++ +CK+ + F + LQ Q + K + T +E++GA
Sbjct: 1475 QKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV 1534
Query: 1122 --DLEQVEVLQKKFDDFQKDL-------KANESRLKDINKVAEDLESEGLM-----AEEV 1167
++ +E L + + +++ ++ + E RLK +++ + + + E++
Sbjct: 1535 TEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDL 1594
Query: 1168 QAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQ 1227
+++EV ++ + + ++ + V ++ ++++EL + W +L + +
Sbjct: 1595 IKAKEKEV------EKIEQNGLALIQNKKEDVSSI-VMSTLRELGQTWANLDHMVGQLKI 1647
Query: 1228 LLGSAHEVQRFHRDA-DETKEWIEEKNQAL--------NTDNYGHDLASVQALQRKHEGF 1278
LL S + H+ A D+ ++ E +L + + + ++Q LQ E
Sbjct: 1648 LLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQ 1707
Query: 1279 ERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKR-ADQRKAKLGD 1337
ER L G N L L + HP E L E+N W++L + A+Q ++
Sbjct: 1708 ERSLQKFGSITNQL------LKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKAL 1761
Query: 1338 SHDLQRFLSDFRDLMSWI-------NGIRGLVSSDELAKD--VTGAEALLERHQEHRTEI 1388
QR+ + S + N + ++ ++A D T + + + T
Sbjct: 1762 LQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVK 1821
Query: 1389 DARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQ-CLEL 1447
D+ + EQ QQ+ A A+ I+ L Q LE+A +++ L L+
Sbjct: 1822 DSLFFLHELGEQLKQQVDAS---AASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 1878
Query: 1448 QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAF 1507
+ F + E E W+ E L +D S D + + ++ E+ + Q K +++
Sbjct: 1879 ETFAKSLEALEAWIVEAEEILQGQDPSHSSD-LSTIQERMEE----LKGQMLKFSSMAPD 1933
Query: 1508 ADQLIAAGH-YAKGDISSRRNEVLDR-WRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEA 1565
D+L G+ D +R + L+R W + +Q E+ SKL L Q +++ E
Sbjct: 1934 LDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL--QSFLLQHQTFLEKCET 1991
Query: 1566 WISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERG 1625
W+ +QT + + N Q LL + + H+ F+AE+ + + +I G L+E+G
Sbjct: 1992 WMEFLVQTEQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQG 2049
Query: 1626 ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEA 1684
D +L L++QWQ +++++ ++ + +Q Q + + WL EV
Sbjct: 2050 Q-VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSY 2108
Query: 1685 LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSA---FDTSQVK 1741
L S L SV L++ + L ++ E L Q ++T A S
Sbjct: 2109 LPMS-----GLGSVPIPLQQARTLFDEVQFKEKVF--LRQQGSYILTVEAGKQLLLSADS 2161
Query: 1742 DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDL 1801
+ +I+ S +L E + F + W K +K + S + R
Sbjct: 2162 GAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL-----KDWEKCEKGIADSLEKLRTF 2216
Query: 1802 TG--VQNLRKKHKRLEAE---LAAHEPAIQGVLDTGKKLS------------DDNTIGKE 1844
Q+L H+ L AE E A+ D +LS DD +I
Sbjct: 2217 KKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISI--- 2273
Query: 1845 EIQQRLAQFVEHWKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDY 1903
+ +R+ W+EL + R Q++ E L E+ F +E W+ + + V+
Sbjct: 2274 -LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN-- 2330
Query: 1904 GDTLAAIQGLLKK-HEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGK 1962
GD L I+ +++K + ++ + + ++ + G+ L K ++ E+ +S+++ GK
Sbjct: 2331 GDIL--IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH---ESKASEIEYKLGK 2385
Query: 1963 VSD-----LEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSS-- 2015
V+D L+ AA+ K + A Q + + +W+ E+ L +S
Sbjct: 2386 VNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEE 2445
Query: 2016 VQTLLTKQETFDAGLQAFQQEGIANITALKDQLL-----AAKHVQSKAIEARHASLMKRW 2070
+Q L +Q+ ++ G+A++ L + LL A + +I+ +L +RW
Sbjct: 2446 IQRKLNEQQELQRDIEK-HSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 2504
Query: 2071 SQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP-----VRC 2125
+ A S R+ K+ E ++K F S F W +++E P +
Sbjct: 2505 RNICAMSMERRLKIEETWRLWQK-------FLDDYSRFEDWLKSSERTAAFPSSSGVIYT 2557
Query: 2126 NSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR 2185
+ EE+K L+ + Q L R+ ++ S + + W
Sbjct: 2558 VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQ---MVHEGNQRWD 2614
Query: 2186 NLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYL--------LDGS 2237
NLQK + RR + R+EF ++ W+ E L D
Sbjct: 2615 NLQK-------RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 2667
Query: 2238 CMVEESGTLESQLEATKRKHQEIRAMRSQL-KKIEDLGAAMEE 2279
+++ + ++ K ++I A QL +K E L AA+ E
Sbjct: 2668 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 2710
Score = 147 bits (371), Expect = 1e-34
Identities = 373/2042 (18%), Positives = 817/2042 (40%), Gaps = 278/2042 (13%)
Query: 436 DEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDL 495
D E + ++ R+ L + L+ QYE+ + +T Q M+ + +++
Sbjct: 1089 DMYDELMMIIGSRRSGLNQNLTLK-SQYERALQDLADLLETGQEK--MAGDQKIIVS--- 1142
Query: 496 GDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRR 555
S + ++ LL KH+++ + L E + + K+I +A++ L+++
Sbjct: 1143 --SKEEIQQLLDKHKEYFQGL---ESHMILTETLFRKIIS---FAVQKETQFHTELMAQA 1194
Query: 556 NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDE------AYKDPSNLQG 609
+A+ +RA +R +L ++ + + DE + ++ +++ ++ L
Sbjct: 1195 SAVLKRAHKRGVELE---YILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLID 1251
Query: 610 KVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW-----KKLL 664
++ +Q ++ L+ Q ++ + G++L+ + ++ +++N++ W K
Sbjct: 1252 RITLYQHLKSSLNEYQPKLYQVLDDGKRLLI--SISCSDLESQLNQLGECWLSNTNKMSK 1309
Query: 665 EATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLA-----SDDYGKDLTNVQNLQKK 719
E L+ I Q + D+ WL + L S ++L V++
Sbjct: 1310 ELHRLETILKHWTRYQSES----ADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 1365
Query: 720 HALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
+V A + Q D ++ + + +++ L + A ++K
Sbjct: 1366 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEK 1425
Query: 780 LADSLRLQQL--FRDVEDEETWIREKEPIAASTNRG-KDLIG---VQNLLKKHQALQAEI 833
L L++ +L + + +WI E + K+ IG + L+K++ + +I
Sbjct: 1426 L-HQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 1484
Query: 834 AGHEPRI----KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDS 889
+ + ++V Q + VE D +L +N+ W+ L+ +++ Q LE
Sbjct: 1485 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 1544
Query: 890 LQA-QQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQA 948
L++ +Y + ++W +E + D+ S + LK + L + A ++
Sbjct: 1545 LESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEK 1604
Query: 949 LREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDW--WK 1006
+ + + Q E +V++ ++ + G + LL S W K
Sbjct: 1605 IEQNGLALIQN----KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHK 1660
Query: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDN----------QTRIT 1056
V + ++ ++ S SR LL GS+ Q Q+DN Q R
Sbjct: 1661 VAFDKINSYL-------MEARYSLSRFRLLT--GSLEAVQVQVDNLQNLQDDLEKQERSL 1711
Query: 1057 KEAGSVSLRMKQ------VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEK 1110
++ GS++ ++ + E L ++L E+ + +LE+ ++ + LQ W K
Sbjct: 1712 QKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKAL--LQLWQRYK 1769
Query: 1111 EAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAV 1170
+ S++ + ++Q E D + LKA ++ ++VA ++ + + + V
Sbjct: 1770 DY---SKQCASTVQQQE------DRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTV 1820
Query: 1171 QQQEVY----GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ-LAEER 1225
+ + G + + D+ AS +S +L L++ +L+Q L +++
Sbjct: 1821 KDSLFFLHELGEQLKQQVDASAASAIQSDQL------------SLSQHLCALEQALCKQQ 1868
Query: 1226 SQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGH--DLASVQALQRKHEGFERDLA 1283
+ L + + F + + + WI E + L + H DL+++Q + +G +
Sbjct: 1869 TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFS 1928
Query: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQR 1343
++ ++ L E RL + E ++ LN+ WS + + +R +KL Q
Sbjct: 1929 SMAPDLDRLNELGYRLPLNDKEI-----KRMQNLNRHWSLISSQTTERFSKL------QS 1977
Query: 1344 FLSDFRDLM----SWINGIRGLVSSDELAKDVTGA-EALLERHQEH---RTEIDARAGTF 1395
FL + + +W+ + + + +LA +++G + LLE+ + H + E+ +R
Sbjct: 1978 FLLQHQTFLEKCETWMEFL--VQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQIL 2035
Query: 1396 QAFEQFGQQLLAHGHYAS-PEIKQKLDILDQERADLEKAWVQRRMMLD-QCLELQLFHRD 1453
+ GQ+LL G E KL +L + + + QRR ++D Q + Q +
Sbjct: 2036 HSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 2095
Query: 1454 CEQAENWMAAREAFLNTEDKGD---SLDSVEALIKKHEDFDKA-INVQEEKIAALQAFAD 1509
E+ W+ ++L G L L + + +K + Q I ++A
Sbjct: 2096 AEKLRKWLV-EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQ 2154
Query: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE 1569
L++A A+ + + E+ ++W+ ++ E++ KL +D ++ E I++
Sbjct: 2155 LLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAF------LLKDWEKCEKGIAD 2208
Query: 1570 KLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGV-------------ID 1616
L+ K LS+ L H + ELHA R + + +
Sbjct: 2209 SLEKLRTFKKK------LSQSLPDHHE------ELHAEQMRCKELENAVGSWTDDLTQLS 2256
Query: 1617 MGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDF 1675
+ + A + R+ L QW+ L + + + Q++ E N+ F+ K+
Sbjct: 2257 LLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKEL 2316
Query: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSS-A 1734
WL+++E+ ++ D+ + K + + +I+ ++ L + L +S
Sbjct: 2317 CEWLTQMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHE 2373
Query: 1735 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIK--EKKLL 1791
S+++ K +N R+Q + + A+R KL E+ + Q ++M +W+ E +L
Sbjct: 2374 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 2433
Query: 1792 VGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDD-----NTIGKEEI 1846
+ +Q + + L+ ++ H + VL+ + L D + I
Sbjct: 2434 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 2493
Query: 1847 QQRLAQFVEHWKELKQLAAARGQRLEESLE-YQQFVANVEEEEAWI-NEKMTLVASEDYG 1904
QQ W+ + ++ R ++EE+ +Q+F+ + E W+ + + T G
Sbjct: 2494 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSG 2553
Query: 1905 DTLAAIQGLLKKHEAFETDF----------------TVHKDRVNDVCTNGQDLIKKNNHH 1948
+ LKK EAF+ ++R + C+ Q ++ + N
Sbjct: 2554 VIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQ-MVHEGNQR 2612
Query: 1949 EENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDD 2008
+N+ ++ + + L+ QR+ +F D + W+ E + L +
Sbjct: 2613 WDNLQKRVTSI---LRRLKHFIGQRE----------EFETARDSILVWLTEMDLQLTNIE 2659
Query: 2009 YGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMK 2068
+ + VQ + + L+AFQQE ++ H + + I A+ L++
Sbjct: 2660 HFSECD-VQAKIKQ-------LKAFQQE------------ISLNHNKIEQIIAQGEQLIE 2699
Query: 2069 RWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSL 2128
+ L ++A +++L E + + ++V + KK + E DL+D R L
Sbjct: 2700 KSEPL--DAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSD--RELEL 2753
Query: 2129 EEIKALREAH--DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRN 2186
E+ AL + H D SL S Q N L + ++S R S T +++++ W +
Sbjct: 2754 EDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER--SGRDTPASVDSIPLEWDH 2811
Query: 2187 LQKIIKERELELQKEQRRQEENDKLRQEFAQHA--------NAFHQWIQETRTYLLDGSC 2238
+ ++ E + + ++E + ++F +A I++ L D
Sbjct: 2812 DYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRF 2871
Query: 2239 MVEESGT-----------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL--ILDN 2285
++++ L++ + + E + +K++E EE+L ++
Sbjct: 2872 QIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNL 2931
Query: 2286 KYTEHSTVGLAQQWDQLDQLG----MRMQHNLEQQIQARNT-------TGVTEEALKEFS 2334
TE T G+ +W+ L +RM+ NL++ Q + G TEE L++
Sbjct: 2932 HSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 2991
Query: 2335 MM 2336
+
Sbjct: 2992 RL 2993
Score = 117 bits (293), Expect = 1e-25
Identities = 343/1750 (19%), Positives = 691/1750 (39%), Gaps = 214/1750 (12%)
Query: 49 FQRDAEELEKWIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGN 107
++ + + L+ W + ++ ++ D ++Q L+ Q E ++A + K+++ G
Sbjct: 1551 YENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGL 1610
Query: 108 LMI-SEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIN 166
+I ++ S + + L EL + W L + + +K+L L Q+ + D IN
Sbjct: 1611 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQ--LKILLKSVLDQWSSH-KVAFDKIN 1667
Query: 167 D-----KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
+ ++ L LE V+V + Q D+ E + + +L++E HP
Sbjct: 1668 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 1727
Query: 222 E-EELIKTKQDEVNAAWQRL-KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQL-- 277
E + EVN W L + +A Q Q QR+ + S ++++E
Sbjct: 1728 PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTN 1787
Query: 278 -MASDDFGRDLAS--VQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQV 334
+ +D+A V ++ L + L ++D + L ++L+Q SA +
Sbjct: 1788 ELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA-I 1846
Query: 335 KREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD-------LTSWVTEMKALINAD 387
+ ++L + + L A A LQ + D+ L +W+ E + ++
Sbjct: 1847 QSDQLSLS----QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ 1902
Query: 388 ELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSE 447
+ S + + +R +E KG++ D + L +D+ +++ L+
Sbjct: 1903 D-PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE--LGYRLPLNDKEIKRMQNLNR 1959
Query: 448 ----------ERAALLELWELRRQQY-EQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496
ER + L+ + L+ Q + E+C F TEQ L ++
Sbjct: 1960 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQK-----------LAVEIS 2008
Query: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRR- 555
+ + + HE F+ + ++++ + ++ +L++ D + LLS +
Sbjct: 2009 GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQW 2068
Query: 556 NALHERAMRRRAQLADSFHLQQFFRD-SDELKSWVNEKMKTATDEAYKDPSNLQ------ 608
+ RA +RR + Q +R+ +++L+ W+ E P LQ
Sbjct: 2069 QGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLF 2128
Query: 609 GKVQ-KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667
+VQ K + F L S I +E Q L+ + A+ + A + E+ WK
Sbjct: 2129 DEVQFKEKVF---LRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRL 2185
Query: 668 ELKGIKLREANQQ-QQFNRNVEDI--ELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLE 724
E + KL + ++ + + D +L ++ + + D+ ++L Q K+ LE
Sbjct: 2186 EEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE---LE 2242
Query: 725 ADVAAHQDRIDGITIQARQFQDAGHFDAENIK---KKQEALVARYEALKEPMVARKQKLA 781
V + D + +++ + + A++I ++ E L ++E L + R+Q++
Sbjct: 2243 NAVGSWTDDLTQLSLLKDTL--SAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 2300
Query: 782 DSLRLQQLFRDVEDEET-WIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
+ L +F + E W+ + E + ++ D++ + + K + Q EIA +
Sbjct: 2301 ERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEKLKKDYQEEIAIAQENK 2357
Query: 841 KAVTQKGNAMVEEGHFA-AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQA-QQYFAD 898
+ Q G + + H + A +++ KL ++N +W+ L + R + L+++L A QQ +
Sbjct: 2358 IQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKN 2417
Query: 899 ANEAESWMREKE-----PIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSI------- 946
+ +W+ E PIV + + + + L + + L D+ + + +
Sbjct: 2418 MSSLRTWLAHIESELAKPIVYDSC---NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLC 2474
Query: 947 QALREQAQSCR--------QQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLN 998
+ L +C QQ D + + + + K E T +
Sbjct: 2475 EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKI--EETWRLWQKFLDDY 2532
Query: 999 STNKDWWKVEVNDRQGFVPAAY----------VKKLDPAQSASRENLLEEQGSIALRQEQ 1048
S +DW K ++R P++ +KK + Q E L + + L +Q
Sbjct: 2533 SRFEDWLKS--SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LELINKQ 2586
Query: 1049 IDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ--- 1105
R + + SL KQ+ + + +KR + + K F+ RE E +
Sbjct: 2587 YRRLARENRTDSACSL--KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSI 2644
Query: 1106 --WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL--ESEG 1161
W+ E + LT+ E ++ + V+ K+ FQ+++ N ++++ I E L +SE
Sbjct: 2645 LVWLTEMDLQLTNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 2703
Query: 1162 LMA----EEVQAVQQ--QEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERW 1215
L A EE+ +++ QEV+G + R K RL + +E
Sbjct: 2704 LDAAIIEEELDELRRYCQEVFGRVERYHK--------KLIRLPLPD----------DEHD 2745
Query: 1216 RSLQQLAEERSQLLGSAHEVQRFH-RDADETKEWIEEKN------QALNTDNYGHDL-AS 1267
S ++L E S L H +H R AD N Q L ++ G D AS
Sbjct: 2746 LSDRELELEDSAALSDLH----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS 2801
Query: 1268 VQA--LQRKHE-GFERDL-AALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSS 1323
V + L+ H+ RDL +A+ + S E + + A L + L
Sbjct: 2802 VDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQ 2861
Query: 1324 LGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVSSDELAKD-VTGAEALLERH 1381
LGK D + ++ + ++ R + +L + G L+ + D V E L+
Sbjct: 2862 LGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEE 2921
Query: 1382 QE--------HRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKA 1433
+E H TE AG +E Q L+ +KQ L Q +DL
Sbjct: 2922 EESLPGFVNLHSTETQT-AGVIDRWELLQAQALSK----ELRMKQNLQKWQQFNSDLNSI 2976
Query: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKA 1493
W ++ +LQ L+T+ + ++E IKK ++ KA
Sbjct: 2977 WAWLGDTEEELEQLQRLE----------------LSTD-----IQTIELQIKKLKELQKA 3015
Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTL 1553
++ ++ I ++ + + A D+ R +++ RW R+ + + E R L ++
Sbjct: 3016 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 3075
Query: 1554 QQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRG 1613
Q ++ + E + +E +N+ L H++ + EL + R+
Sbjct: 3076 CQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVAS 3135
Query: 1614 VIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIK 1673
+ DM L+ +A K ++ + ++ + L++ E S+ +KE K + ++ +
Sbjct: 3136 LQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLLLK---EVSRHIKELEKLLDVSSSQQ 3191
Query: 1674 DFDFWLSEVE 1683
D W S E
Sbjct: 3192 DLSSWSSADE 3201
Score = 112 bits (281), Expect = 3e-24
Identities = 467/2475 (18%), Positives = 938/2475 (37%), Gaps = 370/2475 (14%)
Query: 51 RDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI 110
R+ EEL + I+ +LQ D KD + +L+K QA + QA + E G L +
Sbjct: 135 RETEELRQMIKIRLQNLQDAA-KDMKKFEAELKKLQAALEQAQAT----LTSPEVGRLSL 189
Query: 111 SEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEA 170
E HRQ LL +M K+ Q LR EDV+ + A
Sbjct: 190 KE------------QLSHRQH--LLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA 235
Query: 171 IVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQ 230
+ +E L+H + Q N A ++Q + E+E+ +Q
Sbjct: 236 ALRLQEEASRLQHTAIQQ-------------------CNIMQAAVVQYEQYEQEMKHLQQ 276
Query: 231 DEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASV 290
++G + + K + +Q +
Sbjct: 277 --------LIEGAHREIEDKPVATSNIQELQAQISRH----------------------- 305
Query: 291 QALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELIT-NWEQIRTL 349
+ L +K +G + +A+L K K L +A L+ T+++ E + E + T
Sbjct: 306 EELAQKIKGYQEQIASLNSKCKMLTMKAKHATML--LTVTEVEGLAEGTEDLDGELLPTP 363
Query: 350 AAERHARLNDSYRLQRFLADFRDLT------------------SWVTEMKALINADELAS 391
+A + + R L+ + + S V A +N D
Sbjct: 364 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYY 423
Query: 392 DVAGAEAL-LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERA 450
AE L D + H + E + S A L + + ++ V+SE++
Sbjct: 424 QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKN---VISEKQR 480
Query: 451 ALLELWELRRQQYEQCMD--------LQLFYRDTEQV----DNWMSKQEAFLLNEDL--G 496
L E E R+Q+Y+ + ++L ++ + ++ M++ +A L++E L
Sbjct: 481 TLYEALE-RQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQA-LMDEILMLQ 538
Query: 497 DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRN 556
D ++ +++ L + E +S A + AL T L E ++T R +R
Sbjct: 539 DEINELQSSLAE-ELVSESCEADPAEQLALQSTLTVLA-------ERMSTIRMKASGKRQ 590
Query: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY---KDPSNLQGKVQK 613
L E+ + + LQ++ ++DEL SW+ K D A K+P +++ ++
Sbjct: 591 LLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLST-KATLDTALSPPKEPMDMEAQLMD 649
Query: 614 HQAFEAELSANQSRIDALEKAGQKLI-DVNHYAKDEVAARMNEVISLWKKLLEATELKGI 672
Q E+ + L + L+ + + KDE ++ L LLE + +
Sbjct: 650 CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQ--RAL 707
Query: 673 KLREANQQQQFNRNVE-DIEL----------WLYEV-----EGHLASDDYGKDLTNVQNL 716
++ N Q E D++L WL + + +S K+L Q L
Sbjct: 708 HDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELE--QEL 765
Query: 717 QKKHALLEADVAAHQDRIDGITIQARQFQDAGH--------FDAENIKKKQE-ALVARYE 767
++ +LL + VA+ + I A DAG E K E + ++E
Sbjct: 766 AEQKSLLRS-VASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWE 824
Query: 768 ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQ 827
+L + + KQKL ++ Q+ + + + P+ +D V +LL
Sbjct: 825 SLHQEF-STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLN 883
Query: 828 ALQAEIAGHEPRIKAVTQKGNAMVEEGHFAA---EDVKAKLHELNQKWEALKAKASQRRQ 884
E++ +Q G A + H + V A L+ E L + +
Sbjct: 884 QAFEEVS---------SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPE 934
Query: 885 DLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGS 944
+ E L Q+ A + S +K + S + ++ D+ + + L+ LS S
Sbjct: 935 ETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDS 994
Query: 945 SIQALREQAQSCRQQVAPTDDETGKELVLALYD------------YQEKSPREVT----- 987
+ Q + QQ+ ++ K L +L D +++ ++
Sbjct: 995 VVNQRCHQMKERLQQILNFQNDL-KVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQA 1053
Query: 988 ---MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA-----YVKKLDPAQSASRENL-LEE 1038
+K+ D + D +VE Q + + +S +NL L+
Sbjct: 1054 EDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKS 1113
Query: 1039 QGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGM------LEKSCK 1092
Q AL+ +T K AG + + EE+ L + E +G+ E +
Sbjct: 1114 QYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFR 1173
Query: 1093 KFMLFREANELQ---QWINEKEAALT-SEEVGADLEQVEVLQKKFDDFQKDLKANESRLK 1148
K + F E Q + + + A L + + G +LE + D+ Q++L +
Sbjct: 1174 KIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELS------R 1227
Query: 1149 DINKVAEDLESEGLMAE-EVQAVQQQEVYGMMPR--DETDSKTASPWKSARLMVHTVATF 1205
+ V + S GL+ E E + + + +Y + +E K + ++ +++
Sbjct: 1228 QLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 1287
Query: 1206 N---SIKELNERWRS-LQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALN---- 1257
+ + +L E W S ++++E +L R+ ++ + W++ L
Sbjct: 1288 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ 1347
Query: 1258 -TDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTE 1316
+ +L V+ F +++ A +S+ T +L++ L+ + +
Sbjct: 1348 QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSR 1407
Query: 1317 LNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFR----DLMSWINGIRGLVSSDE-LAKDV 1371
++ W+ L + KL H LQ R ++MSWI+ + ++ DE K+
Sbjct: 1408 IDSQWTDLLTNIPAVQEKL---HQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNS 1464
Query: 1372 TGAEAL---LERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA 1428
G +A+ L++++ + +I+ + T Q Q+ + + K D +Q A
Sbjct: 1465 IGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQD--VESKRSDKTDFAEQLGA 1522
Query: 1429 DLEKAW-------VQRRMMLDQCLEL-QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
+ K+W ++ +L+ LE + + + + W +E L + + SV
Sbjct: 1523 -MNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASV 1581
Query: 1481 EALIKKHEDFDKAINVQEEKIAALQAFADQLI----------------------AAGHYA 1518
+ +K +D + I +E+++ ++ LI A +
Sbjct: 1582 QNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHM 1641
Query: 1519 KGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQ-TLQQFSRDVDEIEAWISE--KLQTAS 1575
G + VLD+W K + S L E++ +L +F +EA + LQ
Sbjct: 1642 VGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQ 1701
Query: 1576 DESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVK 1635
D+ K ++Q ++ + + ++ V N+L+E A E
Sbjct: 1702 DDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIA----EQLQS 1757
Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDL 1695
++ AL WQ S + + +++ + N + + +A ++ +
Sbjct: 1758 SK--ALLQLWQRYKDYSKQCASTVQQQEDRTN--------ELLKAATNKDIADDEVATWI 1807
Query: 1696 ASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIK 1755
N+LLK ++ + + + L Q D+ +SA + Q+ + K
Sbjct: 1808 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA-SAASAIQSDQLSLSQHLCALEQALCK 1866
Query: 1756 SMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSED--YGRDLTGVQNLRKKHKR 1813
+ + L+ F + ++ E+WI E + ++ +D + DL+ +Q ++ K
Sbjct: 1867 QQTSLQAGVLD----YETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKG 1922
Query: 1814 LEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
+ ++ P + + + G +L + +EI+ R+ HW + R +L+
Sbjct: 1923 QMLKFSSMAPDLDRLNELGYRLP----LNDKEIK-RMQNLNRHWSLISSQTTERFSKLQS 1977
Query: 1874 SL-EYQQFVANVEEEEAWIN------EKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTV 1926
L ++Q F+ E+ E W+ +K+ + S +Y L + HE F+ +
Sbjct: 1978 FLLQHQTFL---EKCETWMEFLVQTEQKLAVEISGNYQHLLEQ----QRAHELFQAEMFS 2030
Query: 1927 HKDRVNDVCTNGQDLIKKNNHHE-ENISSKMKGLNGKVSDLEKAAAQRKAKLDEN-SAFL 1984
+ ++ + +GQ L+++ + + + K+ L+ + + + A QR+ +D +
Sbjct: 2031 RQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQ 2090
Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGR---DLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
++ A+ + W+ E + L G L +TL + + + Q I +
Sbjct: 2091 RYREMAEKLRKWLVEV-SYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTV 2149
Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVE------ 2095
A K LL+A A++A A + ++W +KKKL + K E
Sbjct: 2150 EAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADS 2209
Query: 2096 -DLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQ 2154
+ TF KK S S ++ EE + +RC LE +++ S D Q
Sbjct: 2210 LEKLRTFKKKLS--QSLPDHHEELHAEQMRCKELE-------------NAVGSWTDDLTQ 2254
Query: 2155 LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQ- 2213
L+ L + ++ A + + L E LQ+ + EL Q RRQ+ ++L +
Sbjct: 2255 LSLLKDTLSAYISADD------ISILNERVELLQR--QWEELCHQLSLRRQQIGERLNEW 2306
Query: 2214 -EFAQHANAFHQWIQETRTYL-LDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLK-KI 2270
F++ +W+ + + + +G ++EE +E K+ +QE A+ + K ++
Sbjct: 2307 AVFSEKNKELCEWLTQMESKVSQNGDILIEE------MIEKLKKDYQEEIAIAQENKIQL 2360
Query: 2271 EDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEAL 2330
+ +G + +A H + ++ +L ++ R QH L+ I AR + L
Sbjct: 2361 QQMGERLAKA--------SHESKASEIEY-KLGKVNDRWQHLLD-LIAAR------VKKL 2404
Query: 2331 KEFSMMFKHFDKDKS 2345
KE + + DK+ S
Sbjct: 2405 KETLVAVQQLDKNMS 2419
Score = 98.2 bits (243), Expect = 9e-20
Identities = 420/2240 (18%), Positives = 861/2240 (38%), Gaps = 314/2240 (14%)
Query: 123 RLMELHRQWELLLEKMREKGIKLLQAQK-LVQYLRECEDVMDWINDKEAIV-------TS 174
+L ELH+Q + + + KL QA L +Y E ++ WI + + ++
Sbjct: 27 KLTELHQQ---TIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSA 83
Query: 175 EELGQDLEHVEVLQKKFEEFQTDMAAHEERVN---------EVNQFAAKLIQEQHPEEEL 225
+L + + L ++ +E +++ A E++ +++Q A+L +E ++
Sbjct: 84 SQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQM 143
Query: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR 285
IK + + A A ++++F ++ + + +++ + + S + GR
Sbjct: 144 IKIRLQNLQDA-----------------AKDMKKFEAELKKLQAALEQAQATLTSPEVGR 186
Query: 286 DLASVQALLRKHEGLERDLAALEDKVKA--LCAEADRLQQ----SHPLSATQIQVKREEL 339
Q R+H L ++ +L+ KV+A LC A R+ + S PL ++++ E
Sbjct: 187 LSLKEQLSHRQH--LLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEE-- 242
Query: 340 ITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE--------LAS 391
+ +H + +Q + + + ++ LI S
Sbjct: 243 ---------ASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS 293
Query: 392 DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
++ +A + RH+E +I +++ S + + L +A+ LTV E A
Sbjct: 294 NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT----MLLTVTEVEGLA 349
Query: 452 L----LELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG--------DSL 499
L+ L + + R + + N ++ +
Sbjct: 350 EGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPV 409
Query: 500 DSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHY--AMEDVATRRDALLSRR-N 556
+ +A + + + ++LSA+ + A + Y +E AT + L R
Sbjct: 410 ANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWE 469
Query: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
L ++ L ++ QQ ++DS + S E ++ E+ + + + ++ +HQA
Sbjct: 470 TLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQA 529
Query: 617 FEAELSANQSRIDALEKA-GQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGI--- 672
E+ Q I+ L+ + ++L+ + A + +++ + + +K
Sbjct: 530 LMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKR 589
Query: 673 ---------KLREANQQQQFNR---NVEDIELWLYEVEGHLASD--------DYGKDLTN 712
+L E Q+Q R ++++ WL + L + D L +
Sbjct: 590 QLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMD 649
Query: 713 VQNL-----QKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYE 767
QN+ QK AL E V ++G + K + E L +
Sbjct: 650 CQNMLVEIEQKVVALSELSVHNENLLLEG---------------KAHTKDEAEQLAGKLR 694
Query: 768 ALKEPMVARKQKLAD-SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKH 826
LK ++ ++ L D L +Q ++ E+ + DL Q+ +
Sbjct: 695 RLKGSLLELQRALHDKQLNMQGTAQEKEESDV----------------DLTATQSPGVQE 738
Query: 827 QALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDL 886
QA + R ++ Q+ K EL ++ L++ AS R +++
Sbjct: 739 WLAQARTTWTQQRQSSLQQQ---------------KELEQELAEQKSLLRSVAS-RGEEI 782
Query: 887 EDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSI 946
A + DA E + ++ + G +D+ + K E+L + S +
Sbjct: 783 LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQ-----MRMKWESLHQEFSTKQKLL 837
Query: 947 QALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWK 1006
Q + EQ Q P +G L Y+ P T K + +LL+ N+ +
Sbjct: 838 QNVLEQEQEQVLYSRPNRLLSGVPL------YKGDVP---TQDKSAVTSLLDGLNQAF-- 886
Query: 1007 VEVNDRQGFVPAAYV---KKLDPAQSASRENL--LEEQ--GSIALRQEQID----NQTRI 1055
EV+ + G + +KL SA+ L +EE+ + AL E+ + NQ +
Sbjct: 887 EEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEIL 946
Query: 1056 TKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALT 1115
K+ +S M + + L+ + ++E + L + L +N++
Sbjct: 947 AKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLG--CLLGRLSLLDSVVNQR----- 999
Query: 1116 SEEVGADLEQVEVLQKKFDDFQKDLKANESRLKD-----INKVAEDLESEGLMAEEVQAV 1170
Q++ ++ +FQ DLK + L D + K+A E +AE+++A+
Sbjct: 1000 -------CHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQP--VAEQIEAI 1050
Query: 1171 QQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEER----S 1226
QQ E G+ E D+ + + + + +L + + L + R +
Sbjct: 1051 QQAE-DGL---KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLN 1106
Query: 1227 QLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALG 1286
Q L + +R +D + E +EK A + +Q L KH+ + + L
Sbjct: 1107 QNLTLKSQYERALQDLADLLETGQEK-MAGDQKIIVSSKEEIQQLLDKHKEYFQGL---- 1161
Query: 1287 DKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFL- 1345
+ L ET R I S E + TEL S++ KRA +R +L + L
Sbjct: 1162 ESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLD 1219
Query: 1346 SDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER---HQEHRTEIDARAGTFQAFEQFG 1402
D ++L + + + S L ++ + L++R +Q ++ ++ G
Sbjct: 1220 EDQQELSRQLEVVESSIPSVGLVEE--NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 1277
Query: 1403 QQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQ---CLELQLFHRDCEQAE- 1458
++LL I L+ + L + W+ + + LE L H Q+E
Sbjct: 1278 KRLL---------ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSES 1328
Query: 1459 ----NWMAAREAFL-----NTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFAD 1509
+W+ + + L + L+ V + +F K ++ Q +++ + +
Sbjct: 1329 ADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGN 1388
Query: 1510 QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRD-VDEIEAWIS 1568
QL+ + S + + +W L + + KL + Q + SR + E+ +WIS
Sbjct: 1389 QLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWIS 1448
Query: 1569 EKLQTASDESYKDPTNIQLS---KLLSKH-QKHQAFEAELHANADRI----RGVIDMGNS 1620
+ KD NI+ S K + ++ QK++ F+ +++ + + V+ + +
Sbjct: 1449 ----LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQ 1504
Query: 1621 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKE-ANKQQNFNTGIKDFDFWL 1679
+E ++ A +L A+ WQ L EK Q L+ + ++ W
Sbjct: 1505 DVESKRSDKTDFA--EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF 1562
Query: 1680 SEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQ 1739
E L + D ASV N LK Q LE I A E ++ + +L+ + D S
Sbjct: 1563 ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSS 1622
Query: 1740 -VKDKRDTINGRFQKIKSMAASRRAKLN------ESHRLHQFFRDMDDEESWIKEK---- 1788
V + + + M + L SH++ D S++ E
Sbjct: 1623 IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKV-----AFDKINSYLMEARYSL 1677
Query: 1789 ---KLLVGS-EDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVL-DTGKKLSDDNTIGK 1843
+LL GS E + +QNL+ ++ E L +L + +++ T
Sbjct: 1678 SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTL 1737
Query: 1844 EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASED 1902
+E+ R +E E Q + A Q + +Y +Q + V+++E NE + ++D
Sbjct: 1738 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 1797
Query: 1903 YGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEEN-ISSKMKGLNG 1961
D A + ++ + TV KD + + G+ L ++ + + I S L+
Sbjct: 1798 IADDEVA-TWIQDCNDLLKGLGTV-KDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQ 1855
Query: 1962 KVSDLEKAAAQRKAKLDENSA-FLQFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQT 2018
+ LE+A +++ L + F + +E+WI E E L+ D + DLS++Q
Sbjct: 1856 HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQE 1915
Query: 2019 LLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSA 2078
+ + + Q + +A ++L + K I+ R +L + WS + + +
Sbjct: 1916 RMEELKG-----QMLKFSSMAPDLDRLNELGYRLPLNDKEIK-RMQNLNRHWSLISSQTT 1969
Query: 2079 ARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAH 2138
R KL QS + + TF +K + + E+ L + N + + + AH
Sbjct: 1970 ERFSKL---QSFLLQHQ----TFLEKCETWMEFLVQTEQKLAVEISGN-YQHLLEQQRAH 2021
Query: 2139 DAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKER--- 2194
+ F++ + S Q + + + R ++ +V + L W+ + + ++R
Sbjct: 2022 ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGI 2081
Query: 2195 -ELELQKEQRRQEENDKLRQ 2213
+ ++++ QR +E +KLR+
Sbjct: 2082 IDSQIRQWQRYREMAEKLRK 2101
Score = 88.6 bits (218), Expect = 7e-17
Identities = 222/1185 (18%), Positives = 460/1185 (38%), Gaps = 147/1185 (12%)
Query: 45 RFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGK---LQKHQAFEAEVQANSGAIVK 101
++Q ++ AE+L KW+ E + P LQ + Q E G+ +
Sbjct: 2088 QWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYIL 2147
Query: 102 LDETGN-LMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECED 160
E G L++S A ++ L E+ +W+ ++ E Q +KL L++ E
Sbjct: 2148 TVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEE------QKKKLAFLLKDWEK 2201
Query: 161 VMDWINDK-EAIVT-----SEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAK 214
I D E + T S+ L E + Q + +E + + + + + +++
Sbjct: 2202 CEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDT 2261
Query: 215 LIQEQHPEE-ELIKTKQDEVNAAWQRL-KGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
L ++ ++ + + + W+ L L+L+RQ E F+ E W+
Sbjct: 2262 LSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLT 2321
Query: 273 EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ-SHPLSATQ 331
+ E ++ + D+ + + + + + ++A ++ L +RL + SH A++
Sbjct: 2322 QMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASE 2378
Query: 332 IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELA 390
I+ K ++ W+ + L A R +L ++ +Q+ + L +W+ +++ + A +
Sbjct: 2379 IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-AKPIV 2437
Query: 391 SDVAGAEAL---LDRHQEHKGEIDAHEDSFKSADESGQALL-----AAGHYASDEVREKL 442
D +E + L+ QE + +I+ H S + LL A D +++
Sbjct: 2438 YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 2497
Query: 443 TVLSEERAALLELWELRRQQYEQCMDL-QLFYRDTEQVDNWM-SKQEAFLLNEDLGDSLD 500
L + + RR + E+ L Q F D + ++W+ S + G
Sbjct: 2498 RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 2557
Query: 501 SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHE 560
+ LKK E F++ + E +T L+ + N Y R D+ S + +HE
Sbjct: 2558 VAKEELKKFEAFQRQV---HECLTQLE------LINKQYRRLARENRTDSACSLKQMVHE 2608
Query: 561 RAMR----RRAQLADSFHLQQFFRDSDELKS-------WVNEKMKTATDEAYKDPSNLQG 609
R ++ + L+ F +E ++ W+ E T+ + ++Q
Sbjct: 2609 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQA 2668
Query: 610 KVQKHQAFEAELSANQSRIDALEKAGQKLID--------VNHYAKDEVAARMNEVISLWK 661
K+++ +AF+ E+S N ++I+ + G++LI+ + DE+ EV
Sbjct: 2669 KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFG--- 2725
Query: 662 KLLEATELKGIKLREANQQQQFNRNVEDIE--LWLYEVEGHLASDDYGKDLTNVQNLQKK 719
+E K I+L + + + ++E L ++ H S D NL
Sbjct: 2726 -RVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLS 2784
Query: 720 HALLEADVAAHQD---RIDGITIQARQFQDAGHFDAENIKKK------QEALVARYEALK 770
A + +D +D I ++ D D E+ + +E + L+
Sbjct: 2785 LAQPLRSERSGRDTPASVDSIPLEWDHDYDLSR-DLESAMSRALPSEDEEGQDDKDFYLR 2843
Query: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAAS-TNRGKDLIGVQNLLKKHQAL 829
+ A +++QL + ++D I++ E I S T G +L K + L
Sbjct: 2844 GAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL---DTSYKGYMKL 2900
Query: 830 QAEIAGHEPRIKAVTQKGNAMVEE--GHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
E + +K + K E G + + + +WE L+A+A + ++
Sbjct: 2901 LGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK 2960
Query: 888 DSLQA-QQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSI 946
+LQ QQ+ +D N +W+ G E+ E L + L +D+ I
Sbjct: 2961 QNLQKWQQFNSDLNSIWAWL------------GDTEEELEQLQRLE--LSTDIQTIELQI 3006
Query: 947 QALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWK 1006
+ L+E ++ + K ++L++ + + + + D+ L+ N W +
Sbjct: 3007 KKLKELQKAVDHR---------KAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 3057
Query: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG------SIALRQEQIDNQTR------ 1054
V L+ + ++ L++ QG + L E ID +
Sbjct: 3058 V-------------CSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
Query: 1055 ITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
+A + KQ+ ++ H LLE + + + SC+ + + L+
Sbjct: 3105 SNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE---------- 3154
Query: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES 1159
E+V ++++L K+ K+L+ +L D++ +DL S
Sbjct: 3155 AKEKVHVIGNRLKLLLKEVSRHIKELE----KLLDVSSSQQDLSS 3195
Score = 85.1 bits (209), Expect = 8e-16
Identities = 198/1069 (18%), Positives = 423/1069 (39%), Gaps = 140/1069 (13%)
Query: 41 EDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIV 100
E + F +D E+ EK I + L+ K +L ++ A + + A+
Sbjct: 2187 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVG 2246
Query: 101 K----------LDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQK 150
L +T + IS + R L++ RQWE L ++ L+ Q+
Sbjct: 2247 SWTDDLTQLSLLKDTLSAYISADDISILNERVELLQ--RQWEELCHQLS------LRRQQ 2298
Query: 151 LVQYLREC-------EDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
+ + L E +++ +W+ E+ V+ D+ E+++K +++Q ++A +E
Sbjct: 2299 IGERLNEWAVFSEKNKELCEWLTQMESKVSQNG---DILIEEMIEKLKKDYQEEIAIAQE 2355
Query: 204 RVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAAWQRLKGLALQRQGKLFGA-AEVQRFN 261
++ Q +L + H + I+ K +VN WQ L L R KL VQ+ +
Sbjct: 2356 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 2415
Query: 262 RDVDETISWIKEKEQLMA---------SDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
+++ +W+ E +A S++ R L Q L R E +A++ + +
Sbjct: 2416 KNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCE 2475
Query: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL-QRFLADFR 371
L + D IQ L W I ++ ER ++ +++RL Q+FL D+
Sbjct: 2476 VLLHDCDACATD--AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYS 2533
Query: 372 DLTSWVTEMK---ALINADELASDVAGAEALLDRHQEHKGEID----------------A 412
W+ + A ++ + VA E L + + + ++ A
Sbjct: 2534 RFEDWLKSSERTAAFPSSSGVIYTVAKEE--LKKFEAFQRQVHECLTQLELINKQYRRLA 2591
Query: 413 HEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLF 472
E+ SA Q ++ G+ D +++++T + L+ + +R+++E D L
Sbjct: 2592 RENRTDSACSLKQ-MVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARDSILV 2646
Query: 473 YRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATK 532
W+++ + L N + D V+A +K+ + F++ +S KI + +
Sbjct: 2647 ---------WLTEMDLQLTNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQ 2696
Query: 533 LIQNNH--------YAMEDVATRRDALLSRRNALHERAMR------------RRAQLADS 572
LI+ + ++++ + R H++ +R R +L DS
Sbjct: 2697 LIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDS 2756
Query: 573 FHLQQFF---RDSDELKS-WVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
L R +D L S + + + + + + + + E +
Sbjct: 2757 AALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS 2816
Query: 629 DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVE 688
LE A + + ++DE + L A L G +Q +Q + ++
Sbjct: 2817 RDLESAMSRALP----SEDEEGQDDKDFY-----LRGAVGLSGDHSALESQIRQLGKALD 2867
Query: 689 DIELWLYEVEGHLASDD-YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
D + + E + S G +L K + L + ++ D + + + ++ +++
Sbjct: 2868 DSRFQIQQTENIIRSKTPTGPEL---DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEES 2924
Query: 748 --GHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFR-DVEDEETWIREKE 804
G + + + + ++ R+E L+ ++++ ++ +L+ Q F D+ W+ + E
Sbjct: 2925 LPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
Query: 805 PIAASTNR---GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDV 861
R D+ ++ +KK + LQ + + I ++ + + D+
Sbjct: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL 3044
Query: 862 KAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREK--------EPIV 913
+ +L ++N +W+ + + + R L+D+L Q F + + M E PI
Sbjct: 3045 QDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPID 3104
Query: 914 GSTDYGKDEDSAEALLK-KHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELV 972
+ D +D + L++ KHE L S L + +L++ + TD KE V
Sbjct: 3105 SNLDAEILQDHHKQLMQIKHELLESQL-----RVASLQDMSCQLLVNAEGTDCLEAKEKV 3159
Query: 973 LALYDYQEKSPREVT--MKKGDILTLLNSTNKD---WWKVEVNDRQGFV 1016
+ + + +EV+ +K+ + L ++S+ +D W + D G V
Sbjct: 3160 HVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSV 3208
Score = 79.0 bits (193), Expect = 6e-14
Identities = 337/1826 (18%), Positives = 702/1826 (38%), Gaps = 278/1826 (15%)
Query: 631 LEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVED 689
L+ A QK ++ N +A ++ ++ L ++ + E + KL +A + +++N +E
Sbjct: 3 LDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLEL 62
Query: 690 IELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGH 749
I W+ + + + ++ H L + ++ +T + +
Sbjct: 63 ILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV-- 120
Query: 750 FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFR-DVEDEETWIREKEPIAA 808
+ E + ++ L E L++ + R Q L D+ + + F +++ + + + +
Sbjct: 121 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180
Query: 809 STNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAM-VEEGHFAA--------- 858
S G+ + ++ L Q L +E+ +P+++AV +A+ + E A+
Sbjct: 181 SPEVGR--LSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALR 238
Query: 859 --EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
E+ H Q+ ++A Q Q ++ QQ A+ E +P+ S
Sbjct: 239 LQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI----EDKPVATS- 293
Query: 917 DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQ-------AQSCRQQVAPTD----D 965
+ +A + +HE L + Y I +L + A+ + T+
Sbjct: 294 ----NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLA 349
Query: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025
E ++L L P V M G TLL+ ++ + N PA
Sbjct: 350 EGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR----S 405
Query: 1026 PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRK- 1084
P+ A+ + + + + Q + R+ +A + +E Y LE K
Sbjct: 406 PSPVANTDASVNQD----IAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKL 461
Query: 1085 GMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK------ 1138
G L++S + L+ I+EK+ L E +E QK D Q
Sbjct: 462 GDLQRSWET---------LKNVISEKQRTL--------YEALERQQKYQDSLQSISTKME 504
Query: 1139 --DLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ--EVYGMMPRD-ETDSKTASPWK 1193
+LK +ES + ++ E + LM +E+ +Q + E+ + + ++S A P +
Sbjct: 505 AIELKLSESPEPGRSPESQMAEHQALM-DEILMLQDEINELQSSLAEELVSESCEADPAE 563
Query: 1194 SARLMVHTVATFNSIKELNERWRSLQQLAEER--SQLLGSAHE--VQRFHRDADETKEWI 1249
L + + + +QL EE+ QL E +QR+ +ADE W+
Sbjct: 564 QLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWL 623
Query: 1250 EEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAED 1309
L+T AL E + + A L D N L E ++++ S +
Sbjct: 624 LSTKATLDT-----------ALSPPKEPMDME-AQLMDCQNMLVEIEQKVVALSELSVHN 671
Query: 1310 ----LQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSD 1365
L+ K ++A GK R+ K G +LQR L D + M + D
Sbjct: 672 ENLLLEGKAHTKDEAEQLAGK---LRRLK-GSLLELQRALHDKQLNMQGTAQEKEESDVD 727
Query: 1366 ELAKDVTGA---------------EALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
A G ++ L++ +E E+ + ++ G+++L
Sbjct: 728 LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHS 787
Query: 1411 YA--SPEIKQKLDILDQERA-DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF 1467
A S + +K D+L QE + EK+ + +M + W + + F
Sbjct: 788 AAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRM-----------------KWESLHQEF 830
Query: 1468 LNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSR-R 1526
K L +V +++E+ L + ++L++ KGD+ ++ +
Sbjct: 831 ---STKQKLLQNV---------------LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDK 872
Query: 1527 NEVLDRWRRLKAQMIEKRSKLG----ESQTLQQFSRD-VDEIEAW---ISEKLQTASDES 1578
+ V L E S+ G +S L+Q D V W + E+L A+
Sbjct: 873 SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL 932
Query: 1579 YKD-PTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKAR 1637
++ T + ++L+K K + E + + N + E G + D ++
Sbjct: 933 PEETETCLFNQEILAKDIKEMSEEMDKNKNL--------FSQAFPENG---DNRDVIEDT 981
Query: 1638 LAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSEVEALLASEDYGKDLA 1696
L L + L ++ ++KE +Q NF +K L++ + ++ +
Sbjct: 982 LGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQ 1041
Query: 1697 SVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTS--SAFDTSQVKDKRDTINGRFQKI 1754
V ++ Q E + + + +L + D L S + S+++D D ++
Sbjct: 1042 PVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD-------EL 1094
Query: 1755 KSMAASRRAKLNESHRL-HQFFRDMDD--------EESWIKEKKLLVGSEDYGRDLTGVQ 1805
+ SRR+ LN++ L Q+ R + D +E ++K++V S++ +Q
Sbjct: 1095 MMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE------EIQ 1148
Query: 1806 NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA 1865
L KHK L +H ++ T + ++ Q + + + + A
Sbjct: 1149 QLLDKHKEYFQGLESH------MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAH 1202
Query: 1866 ARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT 1925
RG LE LE ++++E++ ++ ++ +V S ++ ++ GL++++E
Sbjct: 1203 KRGVELEYILETW---SHLDEDQQELSRQLEVVES-----SIPSV-GLVEENE------- 1246
Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEEN------------ISSKMKGLNGKVSDLEKAAAQR 1973
DR+ D T Q L N ++ IS L +++ L +
Sbjct: 1247 ---DRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSN 1303
Query: 1974 KAKLDENSAFLQF---NW------KADVVESWIGEKENSL-----KTDDYGRDLSSVQTL 2019
K+ + L+ +W AD++ W+ ++ L ++ ++L V+
Sbjct: 1304 TNKMSKELHRLETILKHWTRYQSESADLIH-WLQSAKDRLEFWTQQSVTVPQELEMVRDH 1362
Query: 2020 LTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2079
L F + A Q +++ + +QLL K V + + + + + +W+ LL N A
Sbjct: 1363 LNAFLEFSKEVDA-QSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPA 1421
Query: 2080 RKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHD 2139
++KL + Q S + + E+++ + + ++ E + +
Sbjct: 1422 VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHE---YLQKYK 1478
Query: 2140 AFRSSLSSAQADFNQLAELDRQIKSFRVAS--NPYTWFT--MEALEETWRNLQKIIKERE 2195
F+ ++ Q + + + QI S V S + T F + A+ ++W+ LQ ++ E+
Sbjct: 1479 GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEK- 1537
Query: 2196 LELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKR 2255
+Q + E E+ + W ET+ L + + ++++ L+ +
Sbjct: 1538 --IQLLEGLLES----WSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQD 1590
Query: 2256 KHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTV------GLAQQWDQLDQLGMRM 2309
I+A +++KIE G A ++ NK + S++ L Q W LD + ++
Sbjct: 1591 LEDLIKAKEKEVEKIEQNGLA-----LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 1645
Query: 2310 QHNLEQQIQARNTTGVTEEALKEFSM 2335
+ L+ + ++ V + + + M
Sbjct: 1646 KILLKSVLDQWSSHKVAFDKINSYLM 1671
Score = 51.2 bits (121), Expect = 1e-05
Identities = 137/738 (18%), Positives = 288/738 (39%), Gaps = 89/738 (12%)
Query: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDEN 71
+ IQ+ + + R+ +S RR K+E+++R +Q F D E W++ + A+ +
Sbjct: 2491 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPS 2550
Query: 72 YKDP--TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE-TIRTRLMELH 128
T + +L+K +AF+ +V + +++ + E S +++ + E +
Sbjct: 2551 SSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 2610
Query: 129 RQWELLLEKMRE--KGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEV 186
++W+ L +++ + +K Q+ ++ + ++ W+ + + +T+ E + + V+
Sbjct: 2611 QRWDNLQKRVTSILRRLKHFIGQR-EEFETARDSILVWLTEMDLQLTNIEHFSECD-VQA 2668
Query: 187 LQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLKGLAL 245
K+ + FQ +++ + ++ ++ +LI++ P + +I+ + DE+ Q + G
Sbjct: 2669 KIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVE 2728
Query: 246 QRQGKLF----------------------GAAEVQRFNRDVDETISWIKEKE------QL 277
+ KL +++ +R D +S Q
Sbjct: 2729 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQP 2788
Query: 278 MASDDFGRDL-ASVQALLRKHE---GLERDLAALEDKVKALCAEADRLQQSHPLSATQIQ 333
+ S+ GRD ASV ++ + + L RDL + +AL +E + Q
Sbjct: 2789 LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMS--RALPSEDEEGQDDKDFYLRGAV 2846
Query: 334 VKREELITNWEQIRTLAAERHARLNDS-YRLQRFLADFRDLTSWVTEMKALINADELASD 392
+ QIR L L+DS +++Q+ R T EL +
Sbjct: 2847 GLSGDHSALESQIRQLG----KALDDSRFQIQQTENIIRSKTP---------TGPELDTS 2893
Query: 393 VAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAAL 452
G LL + E K +ES + L + A +
Sbjct: 2894 YKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV------------NLHSTETQTAGV 2941
Query: 453 LELWELRRQQ--------YEQCMDLQLFYRDTEQVDNWMSKQE---AFLLNEDLGDSLDS 501
++ WEL + Q + Q F D + W+ E L +L + +
Sbjct: 2942 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 3001
Query: 502 VEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHER 561
+E +KK ++ +K++ ++ I +++ + + Q + D+ R + R + +
Sbjct: 3002 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSL 3061
Query: 562 AMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKV-QKH----QA 616
R L D+ Q F + + E + +E SNL ++ Q H
Sbjct: 3062 LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 3121
Query: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMN-EVISLWKKLLEATELKGIKLR 675
+ EL +Q R+ +L+ +L+ VN D + A+ VI KLL + IK
Sbjct: 3122 IKHELLESQLRVASLQDMSCQLL-VNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK-- 3178
Query: 676 EANQQQQFNRNVEDIELW 693
E + + + +D+ W
Sbjct: 3179 ELEKLLDVSSSQQDLSSW 3196
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,468,319
Number of Sequences: 37866
Number of extensions: 3581727
Number of successful extensions: 24235
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 247
Number of HSP's successfully gapped in prelim test: 826
Number of HSP's that attempted gapping in prelim test: 12683
Number of HSP's gapped (non-prelim): 5615
length of query: 2477
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2358
effective length of database: 13,741,464
effective search space: 32402372112
effective search space used: 32402372112
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.