Guide to the Human Genome
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Search of human proteins with 194595509

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
         (2477 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...  4865   0.0  
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...  4850   0.0  
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]          2684   0.0  
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]        637   0.0  
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...   609   e-173
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...   609   e-173
gi|67782321 spectrin beta isoform a [Homo sapiens]                    568   e-161
gi|67782319 spectrin beta isoform b [Homo sapiens]                    568   e-161
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]          558   e-158
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...   433   e-121
gi|12025678 actinin, alpha 4 [Homo sapiens]                           290   2e-77
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]                  288   4e-77
gi|4501893 actinin, alpha 2 [Homo sapiens]                            280   1e-74
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]                280   1e-74
gi|221316624 dystonin isoform 4 [Homo sapiens]                        278   5e-74
gi|221316622 dystonin isoform 3 [Homo sapiens]                        278   5e-74
gi|221316618 dystonin isoform 2 [Homo sapiens]                        278   5e-74
gi|34577047 dystonin isoform 1 [Homo sapiens]                         278   5e-74
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             278   5e-74
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]                277   1e-73
gi|4557241 actinin, alpha 3 [Homo sapiens]                            260   1e-68
gi|33188443 microfilament and actin filament cross-linker protei...   258   7e-68
gi|33188445 microfilament and actin filament cross-linker protei...   258   7e-68
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [...   203   1e-51
gi|5032281 dystrophin Dp427c isoform [Homo sapiens]                   186   2e-46
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]                  186   2e-46
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]                  186   2e-46
gi|5032285 dystrophin Dp427l isoform [Homo sapiens]                   186   2e-46
gi|5032283 dystrophin Dp427m isoform [Homo sapiens]                   186   2e-46
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof...   170   1e-41

>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 1 [Homo sapiens]
          Length = 2477

 Score = 4865 bits (12618), Expect = 0.0
 Identities = 2477/2477 (100%), Positives = 2477/2477 (100%)

Query: 1    MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
            MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
Sbjct: 1    MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60

Query: 61   QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
            QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
Sbjct: 61   QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120

Query: 121  RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180
            RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
Sbjct: 121  RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180

Query: 181  LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240
            LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
Sbjct: 181  LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240

Query: 241  KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
            KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
Sbjct: 241  KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300

Query: 301  ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
            ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
Sbjct: 301  ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360

Query: 361  YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
            YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
Sbjct: 361  YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420

Query: 421  DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
            DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
Sbjct: 421  DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480

Query: 481  NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
            NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
Sbjct: 481  NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540

Query: 541  MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
            MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
Sbjct: 541  MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600

Query: 601  YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
            YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
Sbjct: 601  YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660

Query: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
            KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
Sbjct: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720

Query: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
            ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
Sbjct: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780

Query: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
            ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
Sbjct: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840

Query: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
            KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
Sbjct: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900

Query: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
            EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
Sbjct: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960

Query: 961  APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY 1020
            APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
Sbjct: 961  APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY 1020

Query: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
            VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
Sbjct: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080

Query: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140
            EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
Sbjct: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140

Query: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200
            KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
Sbjct: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200

Query: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 1260
            TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
Sbjct: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 1260

Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA 1320
            YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
Sbjct: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA 1320

Query: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380
            WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
Sbjct: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380

Query: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM 1440
            HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
Sbjct: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM 1440

Query: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500
            LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
Sbjct: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500

Query: 1501 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560
            IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
Sbjct: 1501 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560

Query: 1561 DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS 1620
            DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS
Sbjct: 1561 DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS 1620

Query: 1621 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1680
            LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS
Sbjct: 1621 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1680

Query: 1681 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1740
            EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV
Sbjct: 1681 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1740

Query: 1741 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800
            KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD
Sbjct: 1741 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800

Query: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1860
            LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL
Sbjct: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1860

Query: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1920
            KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF
Sbjct: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1920

Query: 1921 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN 1980
            ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN
Sbjct: 1921 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN 1980

Query: 1981 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2040
            SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN
Sbjct: 1981 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2040

Query: 2041 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
            ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT
Sbjct: 2041 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100

Query: 2101 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR 2160
            FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR
Sbjct: 2101 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR 2160

Query: 2161 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN 2220
            QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN
Sbjct: 2161 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN 2220

Query: 2221 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA 2280
            AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA
Sbjct: 2221 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA 2280

Query: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF 2340
            LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF
Sbjct: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF 2340

Query: 2341 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM 2400
            DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM
Sbjct: 2341 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM 2400

Query: 2401 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE 2460
            ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE
Sbjct: 2401 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE 2460

Query: 2461 LPTAFDYVEFTRSLFVN 2477
            LPTAFDYVEFTRSLFVN
Sbjct: 2461 LPTAFDYVEFTRSLFVN 2477


>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 2 [Homo sapiens]
          Length = 2472

 Score = 4850 bits (12581), Expect = 0.0
 Identities = 2472/2477 (99%), Positives = 2472/2477 (99%), Gaps = 5/2477 (0%)

Query: 1    MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
            MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
Sbjct: 1    MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60

Query: 61   QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
            QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
Sbjct: 61   QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120

Query: 121  RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180
            RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
Sbjct: 121  RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180

Query: 181  LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240
            LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
Sbjct: 181  LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240

Query: 241  KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
            KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
Sbjct: 241  KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300

Query: 301  ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
            ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
Sbjct: 301  ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360

Query: 361  YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
            YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
Sbjct: 361  YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420

Query: 421  DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
            DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
Sbjct: 421  DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480

Query: 481  NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
            NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
Sbjct: 481  NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540

Query: 541  MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
            MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
Sbjct: 541  MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600

Query: 601  YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
            YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
Sbjct: 601  YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660

Query: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
            KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
Sbjct: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720

Query: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
            ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
Sbjct: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780

Query: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
            ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
Sbjct: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840

Query: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
            KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
Sbjct: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900

Query: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
            EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
Sbjct: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960

Query: 961  APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY 1020
            APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
Sbjct: 961  APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY 1020

Query: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
            VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
Sbjct: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080

Query: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140
            EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
Sbjct: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140

Query: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200
            KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
Sbjct: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200

Query: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 1260
            TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
Sbjct: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN 1260

Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA 1320
            YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
Sbjct: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA 1320

Query: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380
            WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
Sbjct: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER 1380

Query: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM 1440
            HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
Sbjct: 1381 HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM 1440

Query: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500
            LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
Sbjct: 1441 LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK 1500

Query: 1501 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560
            IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
Sbjct: 1501 IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV 1560

Query: 1561 DEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNS 1620
            DEIEAWISEKLQTASDESYKDPTNIQ     SKHQKHQAFEAELHANADRIRGVIDMGNS
Sbjct: 1561 DEIEAWISEKLQTASDESYKDPTNIQ-----SKHQKHQAFEAELHANADRIRGVIDMGNS 1615

Query: 1621 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1680
            LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS
Sbjct: 1616 LIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLS 1675

Query: 1681 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1740
            EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV
Sbjct: 1676 EVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQV 1735

Query: 1741 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800
            KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD
Sbjct: 1736 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1795

Query: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1860
            LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL
Sbjct: 1796 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1855

Query: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1920
            KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF
Sbjct: 1856 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAF 1915

Query: 1921 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN 1980
            ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN
Sbjct: 1916 ETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN 1975

Query: 1981 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2040
            SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN
Sbjct: 1976 SAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIAN 2035

Query: 2041 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
            ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT
Sbjct: 2036 ITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2095

Query: 2101 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR 2160
            FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR
Sbjct: 2096 FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDR 2155

Query: 2161 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN 2220
            QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN
Sbjct: 2156 QIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHAN 2215

Query: 2221 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA 2280
            AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA
Sbjct: 2216 AFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEA 2275

Query: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF 2340
            LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF
Sbjct: 2276 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHF 2335

Query: 2341 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM 2400
            DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM
Sbjct: 2336 DKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFM 2395

Query: 2401 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE 2460
            ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE
Sbjct: 2396 ISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRE 2455

Query: 2461 LPTAFDYVEFTRSLFVN 2477
            LPTAFDYVEFTRSLFVN
Sbjct: 2456 LPTAFDYVEFTRSLFVN 2472


>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
          Length = 2419

 Score = 2684 bits (6958), Expect = 0.0
 Identities = 1371/2482 (55%), Positives = 1793/2482 (72%), Gaps = 77/2482 (3%)

Query: 1    MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI 60
            ++ SG KVLETAE+IQERRQ+VL RY  FKE    R QKLEDSY  Q F+RDA++L KWI
Sbjct: 10   VESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWI 69

Query: 61   QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
             EK+ I +D++Y+DPTN+QGK QKHQ+ EAEVQ  S  + +L++T     + GH A E  
Sbjct: 70   MEKVNILTDKSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEET 129

Query: 121  RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD 180
            +  + EL   W+LLLE   EKG +LL+A K  QY++EC D+++WI DKEAI TS ELG+D
Sbjct: 130  KAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGED 189

Query: 181  LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL 240
             E  EVL KKFE+FQ ++ A E RV EVNQ+A +  +E HP+  LI++KQ+EVNAAW+RL
Sbjct: 190  WERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERL 249

Query: 241  KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
            +GLALQRQ  L  AA +QRF RDV E I WIKEKE ++ S+D+G+DL + + L   H+GL
Sbjct: 250  RGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGL 309

Query: 301  ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
            ER+LA + DKVK LCA+A++L  SHP  A QIQ  +E+L+++WE IR LA  R+ +L  +
Sbjct: 310  ERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQAT 369

Query: 361  YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
            Y   RF +DF +L+ W+ E  A INADEL +DVAG E LLDRHQ+HK EID+++D F+SA
Sbjct: 370  YWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSA 429

Query: 421  DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
            DE+GQ L+ A H ASDEVREK+ +L     ALLELW+ R +QYEQC+D  LFYRD+EQVD
Sbjct: 430  DETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVD 489

Query: 481  NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
            +WMS+QEAFL NEDLG+SL S EALL+KHEDFE++ +AQEEKI  +D+ ATKLI ++HY 
Sbjct: 490  SWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYD 549

Query: 541  MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
             E++   RD LL+RR+AL E+A  RR  L +S  LQ+ + DSD+LK+W+N+K K A DE 
Sbjct: 550  SENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDED 609

Query: 601  YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
            YKD  NL+ +VQK Q FE EL+ N+++++ ++K GQ++I+  HYA D V  R++EV SLW
Sbjct: 610  YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669

Query: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
            ++LLEAT+ KG +L EANQQ QF  N ED++ WL +VE  + S+DYGK L  VQN  +KH
Sbjct: 670  EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729

Query: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
             LLE+ VAA QD++D +T  A  F++ GH D+++I+ +QE+LV R+EALKEP+  RK+KL
Sbjct: 730  GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789

Query: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
             D L LQ + RD EDEE WI+E EP A ST  GKDLI  + LL +H+ +   IA HEPRI
Sbjct: 790  LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849

Query: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
            + +T++GN MVEEGHFAAEDV +++  LNQ  E+L+A+A++R+ DLE ++Q QQY AD +
Sbjct: 850  QEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLH 909

Query: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC-RQQ 959
            EAE+W+REKEPIV +T+YG DE++A ALLKKHEA + DL+++G S++ALR QA +C +QQ
Sbjct: 910  EAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQ 969

Query: 960  VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
             AP +   G++ V+ALYD+Q +SPREVTMKKGD+LTLL+S NKDWWKVE  D QG VPA 
Sbjct: 970  AAPVEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAV 1029

Query: 1020 YVKKLDPAQ-SASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE 1078
            YV++L   +     +   EE G+I  RQEQI+NQ                    Y SLL+
Sbjct: 1030 YVRRLAHDEFPMLPQRRREEPGNITQRQEQIENQ--------------------YRSLLD 1069

Query: 1079 LGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK 1138
              E+R+  L +   +F+L  EA ++ +WI EK+A    E  G +L+ V  LQKKFD+FQK
Sbjct: 1070 RAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKA----ENTGVELDDVWELQKKFDEFQK 1125

Query: 1139 DLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLM 1198
            DL  NE RL+DINKVA+DL  EGL+  E   ++Q                          
Sbjct: 1126 DLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQ-------------------------- 1159

Query: 1199 VHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNT 1258
                       ELN RW SLQ+LA+E+ QLLGSAH V+ FHR+AD+TKE IE+K QAL+ 
Sbjct: 1160 -----------ELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSA 1208

Query: 1259 DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
             + G DL SVQALQR+HEGFERDL  LGDKV  LGETAERL +SHP++ EDLQ +  ELN
Sbjct: 1209 ADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELN 1268

Query: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
            +AW  L  R   RK  L ++     FLS  RDL +WI+ I G+VSS ELA+D+TG E LL
Sbjct: 1269 EAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILL 1328

Query: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438
            ERHQEHR +++A A TFQA E F  +L+  GH+ASPEI++KL  +  ER DLEKAW +R+
Sbjct: 1329 ERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRK 1388

Query: 1439 MMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQE 1498
             +LDQCLELQ+F  +C+Q E+WM ARE  L ++DK  SLDS+EAL+KK +D DKAI  QE
Sbjct: 1389 KILDQCLELQMFQGNCDQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQE 1447

Query: 1499 EKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSR 1558
             KI  L+ FA+ LIA  HYAK +I++R   VLDRW+ LKAQ+I++R+KLG+   L+QF R
Sbjct: 1448 GKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYR 1507

Query: 1559 DVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMG 1618
            D++E+E WISE L TA DESYKD TNIQ      K+ KHQ F  E+   ++++ GVI++G
Sbjct: 1508 DLEELEEWISEMLPTACDESYKDATNIQ-----RKYLKHQTFAHEVDGRSEQVHGVINLG 1562

Query: 1619 NSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFW 1678
            NSLIE  AC G+E+A+K +L  L + W  L++++ +K +KL EA++QQ FNT I+DF+FW
Sbjct: 1563 NSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFW 1622

Query: 1679 LSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTS 1738
            LSE E LLA +D  +DLAS  NLLKKHQLLE ++ A ED LKDLN+ A+ L++S  F+  
Sbjct: 1623 LSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVD 1682

Query: 1739 QVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG 1798
            Q+  K+D +N RF  ++ +AA+   KL E++ L QFF+D+DDEESWI+EK + V S+DYG
Sbjct: 1683 QIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYG 1742

Query: 1799 RDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWK 1858
            RDL GVQNL KKHKRLE EL AHEPAIQ VLD  +KL D   +G+EEIQ RLAQFVEHW+
Sbjct: 1743 RDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWE 1802

Query: 1859 ELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHE 1918
            +LK+LA ARG +LEESLEY QF+ N EEEEAWINEK  L    D GDTLAA Q LL KHE
Sbjct: 1803 KLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHE 1862

Query: 1919 AFETDFTVHKDRVNDVCTNGQDLIKK---NNHHEENISSKMKGLNGKVSDLEKAAAQRKA 1975
            A E DF VH+ RV +VC  G+D++ K        + ISSK++ LN K   L KA A  K 
Sbjct: 1863 ALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKL 1922

Query: 1976 KLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQ 2035
            +L+++ AF +FNWKADVVE+WI +KE SLKT+  G DL    TLL KQ+T DA LQ+FQQ
Sbjct: 1923 QLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQ 1982

Query: 2036 EGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVE 2095
            E +  IT LKD+L++A+H QSKAIE R+A+L+KRW QLL  SA  ++KLLE Q   +K E
Sbjct: 1983 ERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAE 2042

Query: 2096 DLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQL 2155
            DLF+ FA KASA N+W E  EE+L++PV C SL EI+ L++ H+ F +SL+ AQADF  L
Sbjct: 2043 DLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCL 2102

Query: 2156 AELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEF 2215
             ELD+QIK+  V S+PYTW T+E LE TW++L  II+ERE ELQKE+ RQ +N ++ QEF
Sbjct: 2103 LELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEF 2162

Query: 2216 AQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGA 2275
             Q+A+ F QWI ETR Y LDGS +++E+GTLESQLEA KRK +EI+AM+ QL KI DLG 
Sbjct: 2163 EQNASTFLQWILETRAYFLDGS-LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGD 2221

Query: 2276 AMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSM 2335
             +E+ALILD KY   ST+GLAQQWDQL QLG+RMQHNLEQQIQA++  GV+EE LKEFS 
Sbjct: 2222 NLEDALILDIKY---STIGLAQQWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFST 2278

Query: 2336 MFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQE 2395
            ++KHFD++ +GRL H+EF+SCLR L Y LPMVEE E +P+FE  LD VDP R G+VSL++
Sbjct: 2279 IYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLED 2338

Query: 2396 YMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVD 2455
            Y AF+I +E+EN+KSS+EIE+AF+AL +EGK Y+TKE++ Q LT EQ  +C +HM+ Y+D
Sbjct: 2339 YTAFLIDKESENIKSSDEIENAFQAL-AEGKSYITKEDMKQALTPEQVSFCATHMQQYMD 2397

Query: 2456 GKGRELPTAFDYVEFTRSLFVN 2477
             +GR   + +DYV FT S F N
Sbjct: 2398 PRGRSHLSGYDYVGFTNSYFGN 2419


>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
          Length = 3639

 Score =  637 bits (1644), Expect = 0.0
 Identities = 544/2269 (23%), Positives = 999/2269 (44%), Gaps = 109/2269 (4%)

Query: 30   KELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDENYKDPTNLQGKLQKHQAF 88
            K L   R+Q L++    Q F R+ +         +  +  D   +D       LQ+H+ F
Sbjct: 1159 KVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREF 1218

Query: 89   EAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA 148
               +         L   G  ++   H A+ T+R +L  +  QW  L  +  ++  +LL +
Sbjct: 1219 GRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLAS 1278

Query: 149  QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEV 208
             +L ++ ++  ++M W+ +K  +   E  G     ++ L K+ E  ++++ A    V  +
Sbjct: 1279 LQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAESELLATRRHVEAL 1337

Query: 209  NQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETI 268
             Q   +L+  +   +E I+T+   + + W+ L     +R  +L  A + ++  R + +  
Sbjct: 1338 QQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAK 1397

Query: 269  SWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHP-L 327
              +++ E  + S + G+DL S Q L ++H+ LE +   L  K+ AL + A  +  S   L
Sbjct: 1398 EQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAIL 1457

Query: 328  SATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINAD 387
              TQ  ++R EL+     IR L      +L  S  L +F        SWV E     +  
Sbjct: 1458 EETQKHLRRLELLQGHLAIRGL------QLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511

Query: 388  ELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSE 447
                 + GA++L  +H+E + E+ AH+   +    SG++L A+GH  +  + E+   L  
Sbjct: 1512 SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEG 1571

Query: 448  ERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLK 507
              A L    E R Q  +Q +  Q ++ D  +++ W+ ++   + + D G    +   L+ 
Sbjct: 1572 HWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLIN 1631

Query: 508  KHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRA 567
            KH+  ++ L+     +  LD+ A  L        + V   R  L  +  AL E A  R  
Sbjct: 1632 KHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDR 1689

Query: 568  QLADSFHLQQFFRDSDELKSWVNEKMKTAT--DEAYKDPSNLQGKVQKHQAFEAELSANQ 625
            +L  +  L +F R++++L+ W+  + + A   +   +DP +      K   F+ ++    
Sbjct: 1690 ELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGS 1749

Query: 626  SRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNR 685
             R+ A     + L++  H A   V  R  ++ + W +L E T+ +G  LR+     + +R
Sbjct: 1750 QRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR 1809

Query: 686  NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745
            ++ ++   + E    L ++   +DL  ++   + H  LE ++   + ++  +   A + Q
Sbjct: 1810 DLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ 1868

Query: 746  D-AGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI-REK 803
                   A  ++++Q+A+   +  L+  M  R+ +L  +  L +    V D  +W  R +
Sbjct: 1869 KLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVR 1928

Query: 804  EPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA 863
            + +    +  +   G   L   HQ L+AE+   E   +  TQ G   +       ++V+ 
Sbjct: 1929 QDLQVEESSQEPSSGPLKL-SAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQE 1987

Query: 864  KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDED 923
            +L  L  + + +    +++++ L+   Q Q +  +    E  +  +E  + ++  G   +
Sbjct: 1988 ELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVE 2047

Query: 924  SAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSP 983
              E L++KHE  +  L+A      ALRE+ ++ R+            L + L   +    
Sbjct: 2048 EVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRP------RVRDRLPILLQ--RRMRV 2099

Query: 984  REVTMKKGDIL---------TLLNSTNKDWWKVEVNDRQGFVPAAYVK-KLDP-----AQ 1028
            +E+   +G  L         T   +  +DW +      +  VP   ++ KL P     A 
Sbjct: 2100 KELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAF 2159

Query: 1029 SASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLE 1088
             A  +   E   S+A + E +  Q+     AG VS R++ + + +  L +    R   LE
Sbjct: 2160 EAEVQAHEEVMTSVAKKGEALLAQSH--PRAGEVSQRLQGLRKHWEDLRQAMALRGQELE 2217

Query: 1089 KSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRL 1147
               + F+ F +  +L + WI EKE  +   ++G DLE    L+++  +F+ +   +    
Sbjct: 2218 DR-RNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGD 2276

Query: 1148 KDINKVAE-DLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFN 1206
              I  +++  L+ +    EEV+ + Q+                                 
Sbjct: 2277 ACIRSISDLSLQLKNRDPEEVKIICQRR-------------------------------- 2304

Query: 1207 SIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLA 1266
               +LN RW S         Q L  A E+    R+ D   + I+EK   +   + G DL 
Sbjct: 2305 --SQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLE 2362

Query: 1267 SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGK 1326
            SVQ L RKHE  ER++  +  +V SL     RL Q  PE+A  L+ +  E+ ++W  L  
Sbjct: 2363 SVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRS 2422

Query: 1327 RADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRT 1386
            RA +R+  L   H  Q+  +  ++L+     +R  + +    +    A  +LE HQE + 
Sbjct: 2423 RAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKA 2482

Query: 1387 EIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLE 1446
            E+D+   +       GQQLL  GH  S +I+Q L  L+QE + LE AW + ++ L Q LE
Sbjct: 2483 ELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALE 2542

Query: 1447 LQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQA 1506
            LQLF    E+ E W+ ++E  L +E   D L  +E L+ KH+  +  + VQ  KI+AL+A
Sbjct: 2543 LQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEA 2602

Query: 1507 FADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566
             A  L   GH        R   +L R   L  Q   +R +L E + LQ F +D  E+ AW
Sbjct: 2603 TARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662

Query: 1567 ISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626
            + EK   A +E   D      + L ++ QK Q F+AEL A+  + + +   G  L++ G 
Sbjct: 2663 LREKNLVALEEGLLD-----TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717

Query: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686
             A   +A++ RL  L   W  L   S +K  KL++A +       +++ + WL  +E  L
Sbjct: 2718 PA--SEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVEL 2775

Query: 1687 ASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDT 1746
             +   G+ L  V  LL   + LEA +     + + L  QA + +         V+++   
Sbjct: 2776 RAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARR 2835

Query: 1747 INGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQN 1806
            +  RF+ ++     RR  L     L +FFRD D+E +W++EK  L  ++DYG+ L+ V++
Sbjct: 2836 LLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRH 2895

Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAA 1866
            L+++H+ LE+E+++HE   + VL TG KL         E+  R+ Q  +    L+  AA 
Sbjct: 2896 LQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAAR 2955

Query: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTV 1926
            R   L+++ E QQF+  + E  +W+ E+  ++ SED G +  A Q LL++ EA + D   
Sbjct: 2956 RRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015

Query: 1927 HKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
               R+  +      L  + N     + ++++ +    ++L + A  R   L E     Q 
Sbjct: 3016 FSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075

Query: 1987 NWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKD 2046
              +  ++++W+  K  + ++ DYG+DL  V+ L  K + F   +Q+  Q  +  +  L  
Sbjct: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135

Query: 2047 QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKAS 2106
             L      +   I+A+ + +   W +L     AR + L  A            +F + A+
Sbjct: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE--------VHSFQQAAA 3187

Query: 2107 AFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFR 2166
                  +     +      +SL  ++ L++ H      L + + +  +L     Q ++ R
Sbjct: 3188 ELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARL-----QTEACR 3242

Query: 2167 VAS-NPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW 2225
            +   +P     +  ++E W  LQ   +ER   L +  +           F         W
Sbjct: 3243 LGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQ--------GHAFLGRCQELLAW 3294

Query: 2226 IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
             QE R  L     + E+    E  L   +   QEIR  R Q + +   G
Sbjct: 3295 AQE-RQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEG 3342



 Score =  570 bits (1468), Expect = e-162
 Identities = 398/1429 (27%), Positives = 700/1429 (48%), Gaps = 80/1429 (5%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74
            +++R   +L R  R KEL+  R   L  S     F + A + E WIQ   Q   +     
Sbjct: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEP--VP 2142

Query: 75   PTNLQGKLQ---KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
            P +L+ KL+   KHQAFEAEVQA+   +  + + G  ++++ H  +  +  RL  L + W
Sbjct: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHW 2202

Query: 132  ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
            E L + M  +G +L   +  +++L+  +    WI +KE  +   +LGQDLEH   L+++ 
Sbjct: 2203 EDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRL 2262

Query: 192  EEFQTDMAAH---EERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
             EF+ + A     +  +  ++  + +L      E ++I  ++ ++N  W    G  L+ Q
Sbjct: 2263 REFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQ 2322

Query: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
             +L GA E+   +R++D     I+EKE L+ + D G+DL SVQ LLRKHE LER++  ++
Sbjct: 2323 QQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQ 2382

Query: 309  DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
             +V++L  E  RL Q  P +A  ++ +++E+  +W Q+R+ A +R   L+  ++ Q+  A
Sbjct: 2383 AQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442

Query: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
              ++L      ++A ++          A  +L+ HQE K E+D+  DS   A  +GQ LL
Sbjct: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502

Query: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
             AGH  S ++R+ L  L +E ++L   W+  + Q +Q ++LQLF    E+++ W+  +E 
Sbjct: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562

Query: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
             L +E L D L  +E LL KH+  E  L  Q  KI+AL+  A  L Q  H   +    R 
Sbjct: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRC 2622

Query: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
             A+L R+ AL  +A  RR +L +   LQ F +DS E+ +W+ EK   A +E   D + L 
Sbjct: 2623 QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLP 2682

Query: 609  GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668
             ++QK Q F+AEL A+  +   L++ GQ+L+   H A + +  R+ E+ +LW +L + ++
Sbjct: 2683 AQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQ 2742

Query: 669  LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728
             K  KL++A +  +  R++E++E WL  +E  L +   G+ L  V  L      LEA V 
Sbjct: 2743 KKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVD 2802

Query: 729  AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
                + + +  QA+ F   GH  A++++++   L+ R+++L+EP+  R+  L     L +
Sbjct: 2803 KKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLK 2862

Query: 789  LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGN 848
             FRD ++E  W++EK P+AA+ + G+ L  V++L ++HQ L++E++ HE   + V   G 
Sbjct: 2863 FFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGY 2922

Query: 849  AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
             +V+ GHFAA +V A++ +L +    L+A+A++RR  L+ + +AQQ+  +  EA SW+ E
Sbjct: 2923 KLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982

Query: 909  KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETG 968
            +  ++ S D G   ++ +ALL++ EA   DL A+   I+ L++ A     +  P   +  
Sbjct: 2983 RGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVL 3042

Query: 969  KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQ 1028
             +L      + E   R     +G  L      ++   +  + D      AA  +  D  Q
Sbjct: 3043 AQLQAVREAHAELLRR--AEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQ 3100

Query: 1029 SASRENLLEEQGSIALRQEQIDNQTRI--------TKEAGS------VSLRMKQVEELYH 1074
                  +LEE+     ++ Q   Q ++        T E G+      +  +  ++E  + 
Sbjct: 3101 DLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWE 3160

Query: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFD 1134
             L +  + R   L  + +     + A ELQ  + EK A +  E+ G  L  V  LQ++  
Sbjct: 3161 RLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHR 3220

Query: 1135 DFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKS 1194
              +++L+A                    M +EV  +Q +                    +
Sbjct: 3221 RLERELEA--------------------MEKEVARLQTE--------------------A 3240

Query: 1195 ARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQ 1254
             RL     A    + ++ E W +LQ  A+ER Q L  A +   F     E   W +E+ +
Sbjct: 3241 CRLGQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE 3300

Query: 1255 ALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAE----- 1308
              +++    D+A  + L  +HE   +++     +   L +  ++L+  SH  SAE     
Sbjct: 3301 LASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECL 3360

Query: 1309 -DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
             +L+ +  EL +AW+        R  +  +S  LQ+         +W+    GL+   + 
Sbjct: 3361 QELEGRLQELEEAWA-------LRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDY 3413

Query: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFE--QFGQQLLAHGHYASP 1414
               V+  E LL RHQ+    + A+   F   +  +  Q+LL       P
Sbjct: 3414 GHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKP 3462



 Score =  548 bits (1413), Expect = e-155
 Identities = 463/1937 (23%), Positives = 876/1937 (45%), Gaps = 91/1937 (4%)

Query: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
            A+ I E+ Q++   +   +     R Q L+ +  FQ +  D  ELE W++EK  + S  +
Sbjct: 1559 AQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRD 1618

Query: 72   Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
            Y +D       + KHQA + E+     ++ +LD+T   +   G    E  R     L  Q
Sbjct: 1619 YGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLT--GPEVPEQQRVVQERLREQ 1676

Query: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWI-NDKEAIVTSEELGQDLEHVEVLQK 189
               L E    +  +L    +L ++LRE ED+  W+ + K+A    E LG+D EH   L  
Sbjct: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736

Query: 190  KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
            KF +FQ  +    +RV      A  L++  H    +++ +Q ++  AW  L  L   R  
Sbjct: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796

Query: 250  KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
             L       R +RD+ E ++ ++EK   + ++   RDL  ++A LR H+GLER+L   E 
Sbjct: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNN-VARDLCGLEAQLRSHQGLERELVGTER 1855

Query: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITN-WEQIRTLAAERHARLNDSYRLQRFLA 368
            +++ L   A R+Q+  P        +R++ +T  W  ++    +R A+L  +  L RF  
Sbjct: 1856 QLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915

Query: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
              RD  SW   ++  +  +E + + +     L  HQ  + E++A E  ++ A + GQ  L
Sbjct: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQAL 1975

Query: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
             A    + EV+E+L  L ++R  + + W  ++++ +     QLF R+  +++  ++ QE 
Sbjct: 1976 LAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEV 2035

Query: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
             L    LG S++ VE L++KHE F K L+AQ++K  AL E    L +        V  R 
Sbjct: 2036 SLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPR------VRDRL 2089

Query: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
              LL RR  + E A  R   L  S  +  F + + + + W+    +   +     P +L+
Sbjct: 2090 PILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV--PPGDLR 2147

Query: 609  GKVQ---KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLE 665
             K++   KHQAFEAE+ A++  + ++ K G+ L+  +H    EV+ R+  +   W+ L +
Sbjct: 2148 DKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQ 2207

Query: 666  ATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEA 725
            A  L+G +L +     +F + V+  E W+ E E  +   D G+DL +   L+++      
Sbjct: 2208 AMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRG 2267

Query: 726  DVAAH---QDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
            + A        I  I+  + Q ++    + + I +++  L  R+ +    ++  +Q+L  
Sbjct: 2268 NSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEG 2327

Query: 783  SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
            +L +  L R++++    I+EKE +  + + GKDL  VQ LL+KH+ L+ E+   + ++++
Sbjct: 2328 ALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVES 2387

Query: 843  VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
            + ++   + +    AA  ++ +  E+ + W  L+++A +RR+ L+   QAQ+  A   E 
Sbjct: 2388 LEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL 2447

Query: 903  ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP 962
                +     + ++   +    A  +L++H+   ++L ++  SI   R   Q       P
Sbjct: 2448 LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHP 2507

Query: 963  TDDE-----TGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNK-DWWKVEVNDRQG-- 1014
               +      G E  L+  +   +  +    +  ++   L+S  K + W     D     
Sbjct: 2508 FSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASE 2567

Query: 1015 --FVPAAYVKKLDPAQSASRENLLEEQGSI-ALRQEQIDNQTRITKEAGSVSLRMKQVEE 1071
              + P A ++ L         +L  + G I AL             EA S   R + +  
Sbjct: 2568 GLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLL 2627

Query: 1072 LYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQK 1131
               +L      R+  LE+  +     +++ E+  W+ EK   +  EE   D   +    +
Sbjct: 2628 RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKN-LVALEEGLLDTAMLPAQLQ 2686

Query: 1132 KFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASP 1191
            K  +FQ +L A+  + +++ +  + L   G  A E  A+Q++                  
Sbjct: 2687 KQQNFQAELDASMHQQQELQREGQRLLQGGHPASE--AIQER------------------ 2726

Query: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251
                            ++EL   W  LQ  ++++   L  A E  R  R  +E + W+E 
Sbjct: 2727 ----------------LEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEP 2770

Query: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK----VNSLGETAERLIQSHPESA 1307
                L     G  L  V  L     G +R+L A  DK      +L   A+  ++     A
Sbjct: 2771 IEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQAQAFVREGHCLA 2826

Query: 1308 EDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
            +D++E+   L Q + SL +   +R+  L     L +F  D  + M+W+     L ++ + 
Sbjct: 2827 QDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDY 2886

Query: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQER 1427
             + ++    L E+HQ   +E+ +     +     G +L+  GH+A+ E+  ++  L++  
Sbjct: 2887 GQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAM 2946

Query: 1428 ADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487
            A L     +RR++L Q  E Q F  +  +A +W+A R   L++ED G S ++ +AL+++ 
Sbjct: 2947 AHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRL 3006

Query: 1488 EDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL 1547
            E   + +     +I  LQ  A  L +  +     + ++   V +    L  +   +   L
Sbjct: 3007 EATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGL 3066

Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHAN 1607
             E   L Q  R+   ++AW++ K  TA  + Y    +++  K+L   +K  AF  E+ + 
Sbjct: 3067 QEQLQLHQLERETLLLDAWLTTKAATAESQDYGQ--DLEGVKVL--EEKFDAFRKEVQSL 3122

Query: 1608 ADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQN 1667
                   +      +ERGA       ++A+ + +   W+ L Q    +++ L  A++  +
Sbjct: 3123 GQAKVYALRKLAGTLERGA-PRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHS 3181

Query: 1668 FNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA- 1726
            F     +    + E  AL+  ED G  L+SV  L ++H+ LE ++ A E  +  L ++A 
Sbjct: 3182 FQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEAC 3241

Query: 1727 --DSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESW 1784
                L  ++    ++V++   T+  + Q+       R   L ++ + H F     +  +W
Sbjct: 3242 RLGQLHPAAPGGLAKVQEAWATLQAKAQE-------RGQWLAQAAQGHAFLGRCQELLAW 3294

Query: 1785 IKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKE 1844
             +E++ L  SE+   D+ G + L  +H+ L  E+       Q +   G++L D++     
Sbjct: 3295 AQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSA 3354

Query: 1845 EIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG 1904
            E+ + L +     +EL++  A R QR  ES   Q+    +E+ EAW+     L+   DYG
Sbjct: 3355 EVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYG 3414

Query: 1905 DTLAAIQGLLKKHEAFE 1921
             +++ ++ LL +H+  E
Sbjct: 3415 HSVSDVELLLHRHQDLE 3431



 Score =  534 bits (1375), Expect = e-151
 Identities = 509/2224 (22%), Positives = 951/2224 (42%), Gaps = 143/2224 (6%)

Query: 115  FASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTS 174
            F   TI      L + +E L    + +  +L +A  L  +   C ++  W+  +  ++  
Sbjct: 827  FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL-- 884

Query: 175  EELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234
            + +    + +EV+Q K+E F T +A  +    EV+  A +L Q        I+ +Q+E++
Sbjct: 885  QRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELS 944

Query: 235  AAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALL 294
              W +L+ L  ++  +L  + EV  F ++   T   +++    + +   G    +  AL 
Sbjct: 945  QRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHAL- 1003

Query: 295  RKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERH 354
               +  ++    LE +V  L +   ++++     +  +Q + E L    +Q++   A+R 
Sbjct: 1004 ---QLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRA 1060

Query: 355  ARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHE 414
             R  ++   Q FL + + L  W   ++A + + E++ DVA A+ LL  HQ+   EI   +
Sbjct: 1061 RRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQ 1120

Query: 415  DSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYR 474
            +  +  D   Q + A     S EV   L VL ++   L  LWE R+Q  ++ ++LQ F R
Sbjct: 1121 ERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR 1180

Query: 475  DTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLI 534
            + +      +  +A+L  ++LG+ +    +LL++H +F + LS    +  AL     KL+
Sbjct: 1181 EVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLV 1240

Query: 535  QNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK 594
            Q+ H A   V  +  ++ ++   L  R+ +RR QL  S  LQ++ +D  EL  W+ EK  
Sbjct: 1241 QSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGL 1300

Query: 595  TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
             A  E      N+   +++H+A E+EL A +  ++AL++ G++L+      ++++  R+ 
Sbjct: 1301 MAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQ 1360

Query: 655  EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714
             + S W+ L      +G +L++A QQ+Q  R ++D +  L ++EG L S + G+DL + Q
Sbjct: 1361 GLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420

Query: 715  NLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMV 774
             LQK+H  LE++      ++  +   A      G   +  I ++ +  + R E L+  + 
Sbjct: 1421 RLQKRHQQLESESRTLAAKMAALASMAH-----GMAASPAILEETQKHLRRLELLQGHLA 1475

Query: 775  ARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA 834
             R  +L  S+ L Q       E +W+ E  P  + T+  + L G Q+L +KH+ LQ E+ 
Sbjct: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535

Query: 835  GHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQ 894
             H+ +++ V   G ++   GH  A+ +  +  EL   W  L+     R Q L+ ++  QQ
Sbjct: 1536 AHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQ 1595

Query: 895  YFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQ 954
            YF D +E E W+ EK P+V S DYG+DE +   L+ KH+AL  +L+ Y SS++ L + AQ
Sbjct: 1596 YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ 1655

Query: 955  SCRQQVAPTD----DETGKELVLALYDYQEKSPREV--TMKKGDILTLLNSTNKDWWKVE 1008
            +      P       E  +E + AL +      RE+  T++  + L             E
Sbjct: 1656 TLTGPEVPEQQRVVQERLREQLRALQELAATRDRELEGTLRLHEFLR------------E 1703

Query: 1009 VNDRQGFVPA-AYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQT------RITKEA-- 1059
              D QG++ +     K   +     E+ L      A  Q Q++  +      R+  E+  
Sbjct: 1704 AEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLL 1763

Query: 1060 -------GSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEA 1112
                     V  R + ++  +  L EL + R   L  +     + R+  E+   + EK  
Sbjct: 1764 ERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKAT 1823

Query: 1113 ALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQ 1172
            +L +  V  DL  +E   +     +++L   E +L+++ + A  ++ +     +  AVQQ
Sbjct: 1824 SLPN-NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQ-KLCPGPQAHAVQQ 1881

Query: 1173 QEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA 1232
            ++                                  + + + W  LQ+  E+R   L  A
Sbjct: 1882 RQ----------------------------------QAVTQAWAVLQRRMEQRRAQLERA 1907

Query: 1233 HEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAA---LGDKV 1289
              + RF     +   W     Q L  +    + +S       H+    +L A   L  + 
Sbjct: 1908 RLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQA 1967

Query: 1290 NSLGETAERLIQSHP-----ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRF 1344
              LG+ A  L    P     E    LQ++  ++ Q W+       +++ +L      Q F
Sbjct: 1968 TQLGQQA-LLAAGTPTKEVQEELRALQDQRDQVYQTWA-------RKQERLQAEQQEQLF 2019

Query: 1345 LSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQ 1404
            L +   L   +      + +  L   V   E L+ +H+     + A+     A  +  + 
Sbjct: 2020 LRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKT 2079

Query: 1405 LLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAA- 1463
            L        P ++ +L IL Q R  +++    R   L   L +  F +   QAE+W+ A 
Sbjct: 2080 L------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAW 2133

Query: 1464 REAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDIS 1523
             +        GD  D ++ L+ KH+ F+  +   EE + ++    + L+A  H   G++S
Sbjct: 2134 AQQLKEPVPPGDLRDKLKPLL-KHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVS 2192

Query: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEK--LQTASDESYKD 1581
             R   +   W  L+  M  +  +L + +   +F + VD  EAWI EK       D     
Sbjct: 2193 QRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDL 2252

Query: 1582 PTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAAL 1641
               +QL + L + + + A +    A    IR + D+   L  R         +  R + L
Sbjct: 2253 EHCLQLRRRLREFRGNSAGDTVGDA---CIRSISDLSLQLKNRD--PEEVKIICQRRSQL 2307

Query: 1642 ADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
             ++W           Q+L+ A +    +  + +    + E EAL+ + D GKDL SV  L
Sbjct: 2308 NNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRL 2367

Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
            L+KH+ LE ++   + +++ L  +   L   S      ++ ++  +   + +++S A  R
Sbjct: 2368 LRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKR 2427

Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821
            R  L+  H+  +    + +     +  +  + +    R     + + ++H+  +AEL + 
Sbjct: 2428 REALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSW 2487

Query: 1822 EPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFV 1881
              +I     TG++L         +I+Q LA   +    L+        +L+++LE Q F+
Sbjct: 2488 TDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFL 2547

Query: 1882 ANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDL 1941
            ++VE+ E W+  K   +ASE   D LA ++ LL KH+  E D  V   +++ +    + L
Sbjct: 2548 SSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGL 2607

Query: 1942 IKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKE 2001
             +  +   ++   + + +  +   L + A  R+ +L+E      F   +  V +W+ EK 
Sbjct: 2608 HQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREK- 2666

Query: 2002 NSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEA 2061
            N +  ++   D + +   L KQ+ F A L A   +    +     +LL   H  S+AI+ 
Sbjct: 2667 NLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQ-QELQREGQRLLQGGHPASEAIQE 2725

Query: 2062 RHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTD 2121
            R   L   W +L  NS  +  KL +A    R          +      +W E  E +L  
Sbjct: 2726 RLEELGALWGELQDNSQKKVAKLQKACEALR--------LRRSMEELENWLEPIEVELRA 2777

Query: 2122 PVRCNSLEEIKAL----REAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTM 2177
            P    +L  +  L    RE   A       A+A   Q     R+                
Sbjct: 2778 PTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCL-----------A 2826

Query: 2178 EALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGS 2237
            + +EE  R L +  K     LQ E+R   E   L  +F + A+    W+QE         
Sbjct: 2827 QDVEEQARRLLQRFKSLREPLQ-ERRTALEARSLLLKFFRDADEEMAWVQEKLPL----- 2880

Query: 2238 CMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQ 2297
               ++ G   S +   + +HQ + +  S  + +  +       L+    +  H      Q
Sbjct: 2881 AAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQ 2940

Query: 2298 QWDQ 2301
            Q ++
Sbjct: 2941 QLEK 2944



 Score =  513 bits (1321), Expect = e-145
 Identities = 548/2418 (22%), Positives = 1012/2418 (41%), Gaps = 212/2418 (8%)

Query: 11   TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASD 69
            + E +Q + + +         L   RR  LE + +   F R+ EE E W++E  Q + + 
Sbjct: 571  SVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNA 630

Query: 70   ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
               +D + + G LQKH+A EAEV  +    V L   G  + +           R   +  
Sbjct: 631  ALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQG 690

Query: 130  QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
             W+LL  ++  +G +L  A  ++QY  +  +   W+ ++ + +     GQD    E L +
Sbjct: 691  GWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLR 750

Query: 190  K---FEEFQTDMAAHEERVNEVNQFAA--------------------------------- 213
            +    E      AA   R+ E  + A+                                 
Sbjct: 751  RHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPG 810

Query: 214  -----KLIQEQHPEEEL----IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDV 264
                 K+     P+ +     I   QD ++  ++ L+ LA  R+ +L  A  +  F    
Sbjct: 811  PGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSC 870

Query: 265  DETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQS 324
             E   W++++  L+       D   V  L  K+E     LA  +     + + A++L+Q 
Sbjct: 871  GELQLWLEKQTVLLQRVQPQADTLEVMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQR 928

Query: 325  HPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALI 384
            +P ++TQIQ ++EEL   W Q+  L  E+  +L  S  +  FL +       + ++   +
Sbjct: 929  YPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL 988

Query: 385  NADELASDVAGAEAL-LDRHQEHKGEIDAH--EDSFKSADESGQALLAAGHYASDEVREK 441
             A +  S      AL L + +    E   H  +      +E G A        S  ++ +
Sbjct: 989  EALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYA-------ESQPLQGQ 1041

Query: 442  LTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDS 501
            +  L      + E    R ++  +    Q F ++++Q+  W    +A L ++++   + S
Sbjct: 1042 VETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVAS 1101

Query: 502  VEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHER 561
             + LL++H+D  + +   +E++  LD  +  +   +    ++V      L  +   L   
Sbjct: 1102 AQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVL 1161

Query: 562  AMRRRAQLADSFHLQQFFRDSDELKSW-VNEKMKTATDEAYKDPSNLQGKVQKHQAFEAE 620
              +R+  L +   LQ+F R+ D   +   N +     D   +D       +Q+H+ F   
Sbjct: 1162 WEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRL 1221

Query: 621  LSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQ 680
            LS    R +AL   G+KL+   H A   V  ++  + + W +L   +E +  +L  + Q 
Sbjct: 1222 LSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL 1281

Query: 681  QQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
            Q++ ++V ++  W+ E +G +A+ +      N+    K+H   E+++ A +  ++ +   
Sbjct: 1282 QEWKQDVAELMQWMEE-KGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQV 1340

Query: 741  ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWI 800
             R+         E+I+ + + L +++EAL   M  R  +L  + + +QL R ++D +  +
Sbjct: 1341 GRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQL 1400

Query: 801  REKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAED 860
             + E    S+  G+DL   Q L K+HQ L++E      R  A      A +  G  A+  
Sbjct: 1401 EQLEGALQSSETGQDLRSSQRLQKRHQQLESE-----SRTLAAKMAALASMAHGMAASPA 1455

Query: 861  VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGK 920
            +  +  +  ++ E L+   + R   L+ S++  Q+   +N   SW+ E  P    T Y +
Sbjct: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515

Query: 921  DEDSAEALLKKHEALMSDLSAYGSSIQAL-----------REQAQSCRQQVAPTDDETGK 969
              + A++L +KH+ L  ++ A+   +Q +             QAQ   +Q    +     
Sbjct: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWA- 1574

Query: 970  ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE----VNDRQ-GFVPAAYVKKL 1024
            EL  A     +   + VT ++      L+ +  + W  E    V+ R  G   AA ++ +
Sbjct: 1575 ELERACEARAQCLQQAVTFQQ----YFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630

Query: 1025 DPAQSASRE-----NLLEE--QGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077
            +  Q+   E     + +EE  Q +  L   ++  Q R+ +E         ++ E   +L 
Sbjct: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQE---------RLREQLRALQ 1681

Query: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWI-NEKEAALTSEEVGADLEQVEVLQKKFDDF 1136
            EL   R   LE + +     REA +LQ W+ ++K+AA   E +G D E    L  KF  F
Sbjct: 1682 ELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKF 1741

Query: 1137 QKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSAR 1196
            Q  ++    R+     +AE L   G  A  +   +QQ+                      
Sbjct: 1742 QHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQD---------------------- 1779

Query: 1197 LMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL 1256
                          L   W  L +L + R   L       R HRD  E    ++EK  +L
Sbjct: 1780 --------------LQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL 1825

Query: 1257 NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCT 1315
              +N   DL  ++A  R H+G ER+L     ++  L ETA R+ +  P   A  +Q++  
Sbjct: 1826 -PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQ 1884

Query: 1316 ELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAE 1375
             + QAW+ L +R +QR+A+L  +  L RF +  RD  SW   +R  +  +E +++ +   
Sbjct: 1885 AVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGP 1944

Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWV 1435
              L  HQ  R E++AR   +Q   Q GQQ L      + E++++L  L  +R  + + W 
Sbjct: 1945 LKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWA 2004

Query: 1436 QRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAIN 1495
            +++  L    + QLF R+C + E  +AA+E  L T   G S++ VE LI+KHE F K + 
Sbjct: 2005 RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLT 2064

Query: 1496 VQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQ 1555
             Q++K AAL+     L       +  +  R   +L R  R+K     +   L  S  +  
Sbjct: 2065 AQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMAS 2118

Query: 1556 FSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVI 1615
            F++   + E WI    Q   +         +L  LL    KHQAFEAE+ A+ + +  V 
Sbjct: 2119 FTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLL----KHQAFEAEVQAHEEVMTSVA 2174

Query: 1616 DMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675
              G +L+ +      E  V  RL  L   W+ L Q  A + Q+L++      F   +   
Sbjct: 2175 KKGEALLAQSHPRAGE--VSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLA 2232

Query: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKD--LNSQADSLMTSS 1733
            + W+ E E  +   D G+DL     L  + +L E   ++  D + D  + S +D  +   
Sbjct: 2233 EAWIQEKEVKMNVGDLGQDLEHCLQL--RRRLREFRGNSAGDTVGDACIRSISDLSLQLK 2290

Query: 1734 AFDTSQVK---DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKL 1790
              D  +VK    +R  +N R+          + +L  +  +H   R++D+    I+EK+ 
Sbjct: 2291 NRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEA 2350

Query: 1791 LVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRL 1850
            L+ + D G+DL  VQ L +KH+ LE E+   +  ++ +     +L   +      ++ R 
Sbjct: 2351 LIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQ 2410

Query: 1851 AQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAI 1910
             +  E W +L+  A  R + L+   + Q+  A ++E           + +     +    
Sbjct: 2411 QEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEA 2470

Query: 1911 QGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAA 1970
            + +L++H+  + +     D ++   + GQ L+   +    +I   + GL  ++S LE A 
Sbjct: 2471 RRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAW 2530

Query: 1971 AQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGL 2030
             + + +L +      F    + +E W+  KE+SL ++     L+ ++ LL K +  +  L
Sbjct: 2531 QEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDL 2590

Query: 2031 QAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSH 2090
            +  Q   I+ + A    L    H ++++   R  +++ R   L   +  R+ +L E +  
Sbjct: 2591 EV-QAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQ- 2648

Query: 2091 FRKVEDLFLTFAKKASAFNSWFEN-----AEEDLTDPVRCNSLEEIKALREAHDAFRSSL 2145
                      F + +    +W         EE L D         + A  +    F++ L
Sbjct: 2649 -------LQAFLQDSQEVAAWLREKNLVALEEGLLDTAM------LPAQLQKQQNFQAEL 2695

Query: 2146 SSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEE---TWRNLQKIIKERELELQKEQ 2202
                A  +Q  EL R+ +      +P +    E LEE    W  LQ   +++  +LQK  
Sbjct: 2696 ---DASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKAC 2752

Query: 2203 RRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA 2262
                E  +LR+   +  N    W++     L         + T+   L        E+  
Sbjct: 2753 ----EALRLRRSMEELEN----WLEPIEVEL--------RAPTVGQALPGV----GELLG 2792

Query: 2263 MRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNT 2322
             + +L+   D  A   EAL+   +        LAQ  ++  +  ++   +L + +Q R T
Sbjct: 2793 TQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRT 2852

Query: 2323 TGVTEEALKEFSMMFKHF 2340
                  AL+  S++ K F
Sbjct: 2853 ------ALEARSLLLKFF 2864



 Score =  474 bits (1219), Expect = e-133
 Identities = 448/1918 (23%), Positives = 797/1918 (41%), Gaps = 177/1918 (9%)

Query: 432  HYASDEVREKLTVLSEERAALLELWE--LRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
            HY S  + +  TV       LL+L E  L + QYEQ +   L          W+++++  
Sbjct: 244  HYCS-RLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLL---------RWIAEKQMQ 293

Query: 490  LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRD 549
            L   D  DSL ++  LL     F      QE+        A + +            RR 
Sbjct: 294  LEARDFPDSLPAMRQLLAAFTIFR----TQEKPPRLQQRGAAEALLFRLQTALQAQNRRP 349

Query: 550  AL----------------LSRRNALHERAMRRRA-QLADSFHLQQFFRDSDELKSWVNEK 592
             L                L    A   +A+++R  QL     L + F+    L+    + 
Sbjct: 350  FLPHEGLGLAELSQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKD 409

Query: 593  MKTATDEAYKDPSNL---QGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEV 649
             +   D+A   P++L   +  VQ+    EA +   + R  AL +    L    +++  +V
Sbjct: 410  AEQVLDQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADV 469

Query: 650  AARMNEVISLWKKLLEATELKGIKLREANQQQQFN--RNVEDIELWLYEVEGHLASDDYG 707
            A R  EV   W++LL+   L+G + + A+ Q   +  + VE     L E++    S   G
Sbjct: 470  ARRQEEVTVRWQRLLQ--HLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACG 527

Query: 708  KDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYE 767
            + L  V  L ++H LLEA V+AH   +  +  Q  +   +     E ++ K   L    +
Sbjct: 528  QQLAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQ 587

Query: 768  ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQ 827
            +L   + AR+  L  +L+  +  R+ E+EE W++E      +   G+DL  +   L+KH+
Sbjct: 588  SLVALVRARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHK 647

Query: 828  ALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
            AL+AE+  H+     + ++G  +         D   +   +   W+ L+ +   R   L+
Sbjct: 648  ALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQ 707

Query: 888  DSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQ 947
             +L   QYFADA EA SW+RE+   +     G+D+ +AE LL++H  L   L A+ + ++
Sbjct: 708  TALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELR 767

Query: 948  ALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGD-ILTLLNSTNKDWWK 1006
             L EQ ++   + +           L   +     P E     G       +    D WK
Sbjct: 768  RLEEQGRAASARAS-----------LFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWK 816

Query: 1007 VEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRM 1066
            +        +PA      DP        +L+ Q  ++   E +    ++ +       R+
Sbjct: 817  MA-------LPAEPDPDFDP------NTILQTQDHLSQDYESLRALAQLRR------ARL 857

Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQV 1126
            ++   L+      GE                     LQ W+ ++   L  + V    + +
Sbjct: 858  EEAMALFGFCSSCGE---------------------LQLWLEKQTVLL--QRVQPQADTL 894

Query: 1127 EVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDS 1186
            EV+Q K+++F   L   +    +++  AE L  +       Q  +QQE            
Sbjct: 895  EVMQLKYENFLTALAVGKGLWAEVSSSAEQLR-QRYPGNSTQIQRQQE------------ 941

Query: 1187 KTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETK 1246
                                   EL++RW  L+ L  E++  L  + EV  F ++   T+
Sbjct: 942  -----------------------ELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQ 978

Query: 1247 EWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPES 1306
              + +    L     G    +  ALQ      ++    L  +V+ L     ++ +     
Sbjct: 979  VQLRDVLLQLEALQPGSSEDTCHALQLA----QKKTLVLERRVHFLQSVVVKVEEPGYAE 1034

Query: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
            ++ LQ +   L      + ++  QR  +  ++   Q FL + + L+ W   ++  + S E
Sbjct: 1035 SQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKE 1094

Query: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQE 1426
            ++ DV  A+ LL  HQ+   EI       Q  +   Q + A     S E+   L +L Q+
Sbjct: 1095 VSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQ 1154

Query: 1427 RADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKK 1486
              +L+  W QR+  L + LELQ F R+ +      A  +A+L+ ++ G+ +    +L+++
Sbjct: 1155 GQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQ 1214

Query: 1487 HEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546
            H +F + ++    +  AL+A  ++L+ + H A   +  +   +  +W RL+ +  ++R +
Sbjct: 1215 HREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQ 1274

Query: 1547 LGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHA 1606
            L  S  LQ++ +DV E+  W+ EK   A+ E      NI     L   ++H+A E+EL A
Sbjct: 1275 LLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNI-----LQTLKRHEAAESELLA 1329

Query: 1607 NADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQ 1666
                +  +  +G  L+ R  C G ED ++ RL  L  +W+ L +K  E+  +L++A +Q+
Sbjct: 1330 TRRHVEALQQVGRELLSRRPC-GQED-IQTRLQGLRSKWEALNRKMTERGDELQQAGQQE 1387

Query: 1667 NFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQA 1726
                 ++D    L ++E  L S + G+DL S   L K+HQ LE++      ++  L S A
Sbjct: 1388 QLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMA 1447

Query: 1727 DSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIK 1786
              +  S A      K  R     R + ++   A R  +L  S  LHQF    + E SW+ 
Sbjct: 1448 HGMAASPAILEETQKHLR-----RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVA 1502

Query: 1787 EKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEI 1846
            E         Y   L G Q+L +KHK L+ E+ AH+  +Q VL +G+ L+       + I
Sbjct: 1503 EHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHI 1562

Query: 1847 QQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDT 1906
             ++  +   HW EL++   AR Q L++++ +QQ+  +V E E W+ EK  LV+S DYG  
Sbjct: 1563 VEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRD 1622

Query: 1907 LAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDL 1966
             AA   L+ KH+A + +  ++   + ++    Q L       ++ +  +   L  ++  L
Sbjct: 1623 EAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRAL 1680

Query: 1967 EKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQET 2025
            ++ AA R  +L+      +F  +A+ ++ W+  ++ + K  +  G D      L TK   
Sbjct: 1681 QELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAK 1740

Query: 2026 FDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLL 2085
            F   ++   Q  +A    L + LL   H     +  R   L   WS+L   + AR   L 
Sbjct: 1741 FQHQVEMGSQR-VAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR 1799

Query: 2086 EAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSL 2145
            + ++  R   DL     +      S   N   DL           ++A   +H      L
Sbjct: 1800 DTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCG---------LEAQLRSHQGLEREL 1850

Query: 2146 SSAQADFNQLAELDRQIKSFRVASNPY-TWFTMEALEETWRNLQKIIKERELELQKEQRR 2204
               +    +L E   +++        +      +A+ + W  LQ+ +++R        R 
Sbjct: 1851 VGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQR--------RA 1902

Query: 2205 QEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMR 2264
            Q E  +L   F      +  W    R  L      VEES    S        HQ +RA  
Sbjct: 1903 QLERARLLARFRTAVRDYASWAARVRQDL-----QVEESSQEPSSGPLKLSAHQWLRAEL 1957

Query: 2265 SQLKKIEDLGAAMEEALIL----DNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQ 2318
               +K+      + +  +L      K  +     L  Q DQ+ Q   R Q  L+ + Q
Sbjct: 1958 EAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015



 Score =  465 bits (1196), Expect = e-130
 Identities = 440/2064 (21%), Positives = 868/2064 (42%), Gaps = 94/2064 (4%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKD 74
            I E  Q+ L R    +    +R  +L+ S     F   +     W+ E +   S  +Y +
Sbjct: 1456 ILEETQKHLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTE 1515

Query: 75   PTN-LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
              N  Q   +KH+  + EV+A+ G + ++  +G  + + GH  ++ I  +  EL   W  
Sbjct: 1516 CLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAE 1575

Query: 134  LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
            L      +   L QA    QY  +  ++  W+ +K  +V+S + G+D      L  K + 
Sbjct: 1576 LERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQA 1635

Query: 194  FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
             Q ++A +   + E++Q A  L   + PE++  +  Q+ +    + L+ LA  R  +L G
Sbjct: 1636 LQEELAIYWSSMEELDQTAQTLTGPEVPEQQ--RVVQERLREQLRALQELAATRDRELEG 1693

Query: 254  AAEVQRFNRDVDETISWI-KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
               +  F R+ ++   W+  +K+     +  G D      L  K    +  +     +V 
Sbjct: 1694 TLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVA 1753

Query: 313  ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372
            A    A+ L +    +   ++ ++++L T W ++  L   R   L D+    R   D  +
Sbjct: 1754 ACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLE 1813

Query: 373  LTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL--LAA 430
            + + V E KA    + +A D+ G EA L  HQ  + E+   E   +   E+   +  L  
Sbjct: 1814 VLTQVQE-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCP 1872

Query: 431  GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
            G  A   V+++   +++  A L    E RR Q E+   L  F        +W ++    L
Sbjct: 1873 GPQAH-AVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDL 1931

Query: 491  LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
              E+      S    L  H+     L A+E+      +   + +       ++V     A
Sbjct: 1932 QVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRA 1991

Query: 551  LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVN-EKMKTATDEAYKDPSNLQG 609
            L  +R+ +++   R++ +L      Q F R+   L+  +  +++   T         ++ 
Sbjct: 1992 LQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQ 2051

Query: 610  KVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATEL 669
             ++KH+ F   L+A   +  AL +  + L       +  V  R+  ++    ++ E  E 
Sbjct: 2052 LIRKHEVFLKVLTAQDKKEAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAES 2105

Query: 670  KGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAA 729
            +G  L  +     F +     E W+      L       DL +      KH   EA+V A
Sbjct: 2106 RGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA 2165

Query: 730  HQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQL 789
            H++ +  +  +        H  A  + ++ + L   +E L++ M  R Q+L D     + 
Sbjct: 2166 HEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEF 2225

Query: 790  FRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNA 849
             + V+  E WI+EKE      + G+DL     L ++ +  +   AG       +    + 
Sbjct: 2226 LQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDL 2285

Query: 850  MVEEGHFAAEDVKA---KLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
             ++  +   E+VK    +  +LN +W +      + +Q LE +L+      + +     +
Sbjct: 2286 SLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRI 2345

Query: 907  REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQAL-REQAQSCRQQVAPTDD 965
            +EKE ++ + D GKD +S + LL+KHE L  ++    + +++L RE  + C++       
Sbjct: 2346 QEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHG 2405

Query: 966  ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK-KL 1024
               ++  +A   +Q +S  +   K+ + L  L+   K    ++   ++  V A  ++ ++
Sbjct: 2406 LRHRQQEVAESWWQLRSRAQ---KRREALDALHQAQK----LQAMLQELLVSAQRLRAQM 2458

Query: 1025 D----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLR--------MKQV--- 1069
            D    P        +LEE        +   +   + +  G   L         ++QV   
Sbjct: 2459 DTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAG 2518

Query: 1070 -EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128
             E+   SL    ++ +  L+++ +  +      ++++W+  KE +L SE +   L  +E 
Sbjct: 2519 LEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEP 2578

Query: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
            L  K    + DL+    ++  +   A  L   G                       ++++
Sbjct: 2579 LLWKHKMLEWDLEVQAGKISALEATARGLHQGG---------------------HPEAQS 2617

Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248
            A     A L+               R  +L + A  R   L    ++Q F +D+ E   W
Sbjct: 2618 ALGRCQAMLL---------------RKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAW 2662

Query: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE 1308
            + EKN     +    D A + A  +K + F+ +L A   +   L    +RL+Q    ++E
Sbjct: 2663 LREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASE 2721

Query: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
             +QE+  EL   W  L   + ++ AKL  + +  R      +L +W+  I   + +  + 
Sbjct: 2722 AIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVG 2781

Query: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERA 1428
            + + G   LL   +E    +D +A   +A     Q  +  GH  + +++++   L Q   
Sbjct: 2782 QALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFK 2841

Query: 1429 DLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHE 1488
             L +   +RR  L+    L  F RD ++   W+  +      +D G SL +V  L ++H+
Sbjct: 2842 SLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQ 2901

Query: 1489 DFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG 1548
            + +  ++  E     +     +L+ AGH+A  ++++R  ++      L+A+   +R  L 
Sbjct: 2902 NLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQ 2961

Query: 1549 ESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
            ++Q  QQF  ++ E  +W++E+      E          + L    ++ +A + +L A +
Sbjct: 2962 QAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALL----RRLEATKRDLEAFS 3017

Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNF 1668
             RI  +      L  R      +  V A+L A+ +    L++++  +   L+E  +    
Sbjct: 3018 PRIERLQQTAALLESRKNPESPK--VLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075

Query: 1669 NTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRLKDLNSQAD 1727
                   D WL+   A   S+DYG+DL  V  L +K      ++ S  + ++  L   A 
Sbjct: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135

Query: 1728 SLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKE 1787
            +L   +      ++ +R  I   ++++     +R   L  +H +H F +   + +  ++E
Sbjct: 3136 TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195

Query: 1788 KKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ 1847
            K  L+  ED G  L+ V+ L+++H+RLE EL A E  +  +     +L   +        
Sbjct: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG-- 3253

Query: 1848 QRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTL 1907
              LA+  E W  L+  A  RGQ L ++ +   F+   +E  AW  E+  L +SE+  + +
Sbjct: 3254 --LAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDV 3311

Query: 1908 AAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLE 1967
            A  + LL +HE    +    + +  D+   GQ L+  ++     ++  ++ L G++ +LE
Sbjct: 3312 AGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELE 3371

Query: 1968 KAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFD 2027
            +A A R  +  E+    +   + +  E+W+   E  L   DYG  +S V+ LL + +  +
Sbjct: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431

Query: 2028 AGLQAFQQEGIANI--TALKDQLL 2049
              L A Q+E  A +  T ++ +LL
Sbjct: 3432 K-LLAAQEEKFAQMQKTEMEQELL 3454



 Score =  450 bits (1158), Expect = e-126
 Identities = 488/2272 (21%), Positives = 923/2272 (40%), Gaps = 180/2272 (7%)

Query: 9    LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIAS 68
            LE AE    R Q +  R  + + L TL R+          FQ  A   E ++++  Q+  
Sbjct: 368  LEWAE--AARSQALQQRLLQLQRLETLARR----------FQHKAALRESFLKDAEQVL- 414

Query: 69   DENYKDPTNL---QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125
            D+    P +L   +  +Q+    EA +    G    L E  +++  E + +   +  R  
Sbjct: 415  DQARAPPASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQE 474

Query: 126  ELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVE 185
            E+  +W+ LL+ ++ +  ++   Q ++  L+E E     + + +    S   GQ L  V 
Sbjct: 475  EVTVRWQRLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVV 534

Query: 186  VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLAL 245
             L ++ +  +  ++AH   V+ + Q  A+L        E+++ K   +    Q L  L  
Sbjct: 535  ELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVR 594

Query: 246  QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
             R+  L    +   F R+ +E  +W+KE  Q + +   GRDL+ +   L+KH+ LE ++ 
Sbjct: 595  ARRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEV- 653

Query: 306  ALEDKVKALCAEADR----LQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY 361
                + +A+C +  R    L    P +      + E +   W+ ++T    R ARL  + 
Sbjct: 654  ---HRHQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTAL 710

Query: 362  RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSAD 421
             + ++ AD  +  SW+ E ++ +       D A AE LL RH   +  + A     +  +
Sbjct: 711  LVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLE 770

Query: 422  ESGQALLAAG---------------------------------------------HYASD 436
            E G+A  A                                                +  +
Sbjct: 771  EQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPN 830

Query: 437  EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLG 496
             + +    LS++  +L  L +LRR + E+ M L  F     ++  W+ KQ   L  + + 
Sbjct: 831  TILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLL--QRVQ 888

Query: 497  DSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRN 556
               D++E +  K+E+F  +L+  +     +   A +L Q        +  +++ L  R  
Sbjct: 889  PQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWG 948

Query: 557  ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
             L      +  QLA S  +  F ++    +  + + +     EA + P + +      Q 
Sbjct: 949  QLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQL--EALQ-PGSSEDTCHALQL 1005

Query: 617  FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
             + +    + R+  L+    K+ +  +     +  ++  +  L K++ E    +  +  E
Sbjct: 1006 AQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAE 1065

Query: 677  ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736
               +Q F +  + + LW   V+  L S +   D+ + Q L ++H  L  ++   Q+R+  
Sbjct: 1066 TQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQ 1125

Query: 737  ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796
            +  Q++        D++ +      L  + + LK     R+Q L + L LQ+  R+V+  
Sbjct: 1126 LDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGF 1185

Query: 797  ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856
                   +      N G+D+    +LL++H+     ++   PR +A+   G  +V+  H 
Sbjct: 1186 TATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHP 1245

Query: 857  AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
            AA  V+ +L  +  +W  L+ ++ QRR+ L  SLQ Q++  D  E   WM EK  +    
Sbjct: 1246 AAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHE 1305

Query: 917  DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976
              G   +  +  LK+HEA  S+L A    ++AL++  +    +  P   E  +  +  L 
Sbjct: 1306 PSGARRNILQT-LKRHEAAESELLATRRHVEALQQVGRELLSR-RPCGQEDIQTRLQGLR 1363

Query: 977  DYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPA-QSASRENL 1035
               E   R++T ++GD L       +   +++    Q       +++L+ A QS+     
Sbjct: 1364 SKWEALNRKMT-ERGDELQQAGQQEQLLRQLQDAKEQ-------LEQLEGALQSSETGQD 1415

Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEK------------- 1082
            L     +  R +Q+++++R      +    M        ++LE  +K             
Sbjct: 1416 LRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLA 1475

Query: 1083 -RKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLK 1141
             R   L+ S +       +N    W+ E     +       L   + L +K  + Q ++K
Sbjct: 1476 IRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVK 1535

Query: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201
            A++ +++ +      L + G    + Q + +Q                            
Sbjct: 1536 AHQGQVQRVLSSGRSLAASG--HPQAQHIVEQ---------------------------- 1565

Query: 1202 VATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNY 1261
                   +EL   W  L++  E R+Q L  A   Q++  D  E + W+EEK   +++ +Y
Sbjct: 1566 ------CQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619

Query: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH-PESAEDLQEKCTELNQA 1320
            G D A+   L  KH+  + +LA     +  L +TA+ L     PE    +QE+  E  +A
Sbjct: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679

Query: 1321 WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE-LAKDVTGAEALLE 1379
               L   A  R  +L  +  L  FL +  DL  W+   +      E L +D   A  L  
Sbjct: 1680 LQEL---AATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736

Query: 1380 RHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRM 1439
            +  + + +++  +    A     + LL  GH A P ++Q+   L    ++L +    R  
Sbjct: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796

Query: 1440 MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEE 1499
             L         HRD  +    +  +   L      D L  +EA ++ H+  ++ +   E 
Sbjct: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARD-LCGLEAQLRSHQGLERELVGTER 1855

Query: 1500 KIAALQAFAD--QLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
            ++  L   A   Q +  G  A   +  R+  V   W  L+ +M ++R++L  ++ L +F 
Sbjct: 1856 QLQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFR 1914

Query: 1558 RDVDEIEAWISEKLQTAS-DESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVID 1616
              V +  +W +   Q    +ES ++P++  L     K   HQ   AEL A     +    
Sbjct: 1915 TAVRDYASWAARVRQDLQVEESSQEPSSGPL-----KLSAHQWLRAELEAREKLWQQATQ 1969

Query: 1617 MGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFD 1676
            +G   +        E  V+  L AL DQ   + Q  A K ++L+   ++Q F       +
Sbjct: 1970 LGQQALLAAGTPTKE--VQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLE 2027

Query: 1677 FWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD 1736
              L+  E  L +   G  +  V  L++KH++    ++A + +   L  +  +L       
Sbjct: 2028 EILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLR------ 2081

Query: 1737 TSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSED 1796
              +V+D+   +  R  ++K +A SR   L+ S  +  F +     E WI+     +    
Sbjct: 2082 RPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV 2141

Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEH 1856
               DL        KH+  EAE+ AHE  +  V   G+ L   +     E+ QRL    +H
Sbjct: 2142 PPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKH 2201

Query: 1857 WKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKK 1916
            W++L+Q  A RGQ LE+   + +F+  V+  EAWI EK   +   D G  L     L ++
Sbjct: 2202 WEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRR 2261

Query: 1917 HEAFETDFTVHKDRVNDVC---TNGQDLIKKNNHHEE--NISSKMKGLNGKVSDLEKAAA 1971
               F  +     D V D C    +   L  KN   EE   I  +   LN + +       
Sbjct: 2262 LREFRGNSA--GDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLL 2319

Query: 1972 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 2031
            + + +L+        + + D V   I EKE  ++  D G+DL SVQ LL K E  +  + 
Sbjct: 2320 RYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVH 2379

Query: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
              Q + + ++     +L       +  +  R   + + W Q L + A ++++ L+A    
Sbjct: 2380 PIQAQ-VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQ-LRSRAQKRREALDALHQA 2437

Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQAD 2151
            +K++ +       A    +  + +    +       LEE +  +   D++  S+S A++ 
Sbjct: 2438 QKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARST 2497

Query: 2152 FNQLAELDRQIKSFRVASNPYT---WFTMEALEETWRNLQKIIKERELELQK 2200
              QL            A +P++      +  LE+   +L+   +E +L+LQ+
Sbjct: 2498 GQQLL----------TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQ 2539



 Score =  422 bits (1086), Expect = e-117
 Identities = 401/1847 (21%), Positives = 806/1847 (43%), Gaps = 94/1847 (5%)

Query: 4    SGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK 63
            +G +V E    +QER ++ L      +EL+  R ++LE + R   F R+AE+L+ W+  +
Sbjct: 1658 TGPEVPEQQRVVQERLREQL---RALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQ 1714

Query: 64   LQIAS--DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIR 121
             Q A   +   +DP +      K   F+ +V+  S  +         ++  GH A   +R
Sbjct: 1715 KQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVR 1774

Query: 122  TRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDL 181
             R  +L   W  L E  + +G  L   +  ++  R+  +V+  + +K A      + +DL
Sbjct: 1775 QRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEK-ATSLPNNVARDL 1833

Query: 182  EHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE-QHPEEELIKTKQDEVNAAWQRL 240
              +E   +  +  + ++   E ++ E+ + A ++ +    P+   ++ +Q  V  AW  L
Sbjct: 1834 CGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVL 1893

Query: 241  KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL 300
            +    QR+ +L  A  + RF   V +  SW     Q +  ++  ++ +S    L  H+ L
Sbjct: 1894 QRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWL 1953

Query: 301  ERDLAALEDKVKALCAEADRLQQSHPLSA----TQIQVKREELITNWEQIRTLAAERHAR 356
              +L A E     L  +A +L Q   L+A     ++Q +   L    +Q+    A +  R
Sbjct: 1954 RAELEAREK----LWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQER 2009

Query: 357  LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416
            L    + Q FL +   L   +   +  +    L S V   E L+ +H+     + A +  
Sbjct: 2010 LQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKK 2069

Query: 417  FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476
              +  E  + L          VR++L +L + R  + EL E R       + +  F +  
Sbjct: 2070 EAALRERLKTL------RRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAA 2123

Query: 477  EQVDNWMSKQEAFLLNEDL--GDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLI 534
             Q ++W+    A  L E +  GD  D ++ LLK H+ FE  + A EE +T++ +    L+
Sbjct: 2124 TQAEDWIQAW-AQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSVAKKGEALL 2181

Query: 535  QNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEK-M 593
              +H    +V+ R   L      L +    R  +L D  +  +F +  D  ++W+ EK +
Sbjct: 2182 AQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEV 2241

Query: 594  KTATDEAYKDPSN---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVA 650
            K    +  +D  +   L+ ++++ +   A  +   + I ++     +L + +      + 
Sbjct: 2242 KMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIIC 2301

Query: 651  ARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDL 710
             R +++ + W            +L  A +    +R ++++   + E E  + + D GKDL
Sbjct: 2302 QRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDL 2361

Query: 711  TNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALK 770
             +VQ L +KH  LE +V   Q +++ +  +  +        A  ++ +Q+ +   +  L+
Sbjct: 2362 ESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLR 2421

Query: 771  EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG-KDLIGVQNLLKKHQAL 829
                 R++ L D+L   Q  + +  E     ++      T+   +  +  + +L++HQ  
Sbjct: 2422 SRAQKRREAL-DALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQEC 2480

Query: 830  QAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDS 889
            +AE+      I      G  ++  GH  + D++  L  L Q+  +L+    + +  L+ +
Sbjct: 2481 KAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQA 2540

Query: 890  LQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQAL 949
            L+ Q + +   + E W+  KE  + S          E LL KH+ L  DL      I AL
Sbjct: 2541 LELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISAL 2600

Query: 950  REQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDI--LTLLNSTNKDWWKV 1007
               A+   Q   P + ++      A+   +E   R+   ++  +  L  L +  +D  +V
Sbjct: 2601 EATARGLHQGGHP-EAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEV 2659

Query: 1008 EVNDRQGFVPAAYVKKLD----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAG--- 1060
                R+  + A     LD    PAQ   ++N   E  +   +Q+++  + +   + G   
Sbjct: 2660 AAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPA 2719

Query: 1061 --SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEE 1118
              ++  R++++  L+  L +  +K+   L+K+C+   L R   EL+ W+   E  L +  
Sbjct: 2720 SEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPT 2779

Query: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGM 1178
            VG  L  V  L       Q++L+A       ++K A   ++E L+ +    V++      
Sbjct: 2780 VGQALPGVGELL----GTQRELEA------AVDKKAR--QAEALLGQAQAFVREGHCLAQ 2827

Query: 1179 MPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRF 1238
               ++                         + L +R++SL++  +ER   L +   + +F
Sbjct: 2828 DVEEQA------------------------RRLLQRFKSLREPLQERRTALEARSLLLKF 2863

Query: 1239 HRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAER 1298
             RDADE   W++EK       +YG  L++V+ LQ +H+  E ++++       +  T  +
Sbjct: 2864 FRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYK 2923

Query: 1299 LIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGI 1358
            L+Q+   +A ++  +  +L +A + L   A +R+  L  + + Q+FL++  +  SW+   
Sbjct: 2924 LVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAER 2983

Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
              ++ S+++       +ALL R +  + +++A +   +  +Q    L +  +  SP++  
Sbjct: 2984 GHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLA 3043

Query: 1419 KLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLD 1478
            +L  + +  A+L +    R   L + L+L    R+    + W+  + A   ++D G  L+
Sbjct: 3044 QLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLE 3103

Query: 1479 SVEALIKKHEDFDKAI-NVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLK 1537
             V+ L +K + F K + ++ + K+ AL+  A  L          I ++R+ +   W RL 
Sbjct: 3104 GVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLD 3163

Query: 1538 AQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKH 1597
              +  +   L  +  +  F +   E++  + EK      E         LS + +  Q+H
Sbjct: 3164 QAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGED----GGHSLSSVRTLQQQH 3219

Query: 1598 QAFEAELHANADRIRGVIDMGNSLIERGACAGSE--DAVKARLAALADQWQFLVQKSAEK 1655
            +  E EL A    +        + ++  AC   +   A    LA + + W  L  K+ E+
Sbjct: 3220 RRLERELEAMEKEV--------ARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQER 3271

Query: 1656 SQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAH 1715
             Q L +A +   F    ++   W  E + L +SE+  +D+A    LL +H+ L  +I   
Sbjct: 3272 GQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIREC 3331

Query: 1716 EDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFF 1775
              + +DL  +   L+ +S F +++V +    + GR Q+++   A R  +  ES  L +  
Sbjct: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391

Query: 1776 RDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1822
            + ++  E+W+   + L+   DYG  ++ V+ L  +H+ LE  LAA E
Sbjct: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQE 3438



 Score =  308 bits (790), Expect = 3e-83
 Identities = 458/2331 (19%), Positives = 897/2331 (38%), Gaps = 223/2331 (9%)

Query: 145  LLQAQKL----VQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAA 200
            LLQ Q+      QY +   D++ WI +K+  + + +    L  +  L   F  F+T    
Sbjct: 263  LLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQ--E 320

Query: 201  HEERVNEVNQFAAKLIQEQ-------------HPEEELIKTKQDEVNAAW-QRLKGLALQ 246
               R+ +     A L + Q             H    L +  Q      W +  +  ALQ
Sbjct: 321  KPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQ 380

Query: 247  RQGKLFGAAE--VQRFNRDVDETISWIKEKEQLMASDDFGR----DLASVQALLRKHEGL 300
            ++       E   +RF        S++K+ EQ++   D  R     LA+V+A +++   L
Sbjct: 381  QRLLQLQRLETLARRFQHKAALRESFLKDAEQVL---DQARAPPASLATVEAAVQRLGML 437

Query: 301  ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
            E  +   E + +AL   AD L+Q    S   +  ++EE+   W+++      +  ++ D 
Sbjct: 438  EAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADM 497

Query: 361  YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA 420
              +   L +    +  + E++    +      +A    LL RH   + ++ AH       
Sbjct: 498  QAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSHL 557

Query: 421  DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
             +    L ++   + + ++ K   L++ + +L+ L   RR   EQ +    F R+ E+ +
Sbjct: 558  AQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEE 617

Query: 481  NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
             W+ +    + N  LG  L  +   L+KH+  E  +   +     L      L       
Sbjct: 618  AWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPT 677

Query: 541  MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA 600
              D   R +A+      L  R + R A+L  +  + Q+F D+ E  SW+ E+ +++ + A
Sbjct: 678  QPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRER-RSSLERA 736

Query: 601  Y--KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQ------KLIDVN---------- 642
               +D +  +  +++H   E  L A  + +  LE+ G+       L  VN          
Sbjct: 737  SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESL 796

Query: 643  -----------------------------HYAKDEVAARMNEVISLWKKLLEATELKGIK 673
                                          +  + +    + +   ++ L    +L+  +
Sbjct: 797  RNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRAR 856

Query: 674  LREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDR 733
            L EA     F  +  +++LWL +    L       D   V  L+ ++ L    +A  +  
Sbjct: 857  LEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFL--TALAVGKGL 914

Query: 734  IDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDV 793
               ++  A Q +     ++  I+++QE L  R+  L+     +  +LA S+ +    ++ 
Sbjct: 915  WAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQEC 974

Query: 794  EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
               +  +R+      +   G      ++     Q  Q +    E R+  +      + E 
Sbjct: 975  GPTQVQLRDVLLQLEALQPGSS----EDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEP 1030

Query: 854  GHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIV 913
            G+  ++ ++ ++  L    + ++ + +QR +   ++   Q +  ++ +   W    +  +
Sbjct: 1031 GYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQL 1090

Query: 914  GSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET------ 967
             S +   D  SA+ LL++H+ L+ ++  +   +Q L  Q+Q       P   E       
Sbjct: 1091 RSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRV 1150

Query: 968  ----GKELVLALYDYQEKSPREVTMKK----GDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
                G+EL +     Q+     + ++K     D  T   + ++ W  +   D  G     
Sbjct: 1151 LGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHL---DNLGEDVRE 1207

Query: 1020 YVKKLDPAQSASRENLLEEQG--SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLL 1077
             +  L   +   R  LL   G  + ALR             A +V  +++ ++  +  L 
Sbjct: 1208 ALSLLQQHREFGR--LLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQ 1265

Query: 1078 ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQ 1137
               E+R+  L  S +     ++  EL QW+ EK      E  GA    ++ L++      
Sbjct: 1266 GRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRH----- 1320

Query: 1138 KDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARL 1197
               +A ES L    +  E L+  G           +E+    P  + D +T         
Sbjct: 1321 ---EAAESELLATRRHVEALQQVG-----------RELLSRRPCGQEDIQT--------- 1357

Query: 1198 MVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALN 1257
                      ++ L  +W +L +   ER   L  A + ++  R   + KE +E+   AL 
Sbjct: 1358 ---------RLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQ 1408

Query: 1258 TDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTEL 1317
            +   G DL S Q LQ++H+  E +   L  K+ +L   A  +  S P   E+ Q+    L
Sbjct: 1409 SSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-PAILEETQKHLRRL 1467

Query: 1318 NQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEAL 1377
                  L  R  Q +A    S +L +F       +SW+       S     + + GA++L
Sbjct: 1468 ELLQGHLAIRGLQLQA----SVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523

Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQR 1437
              +H+E + E+ A  G  Q     G+ L A GH  +  I ++   L+   A+LE+A   R
Sbjct: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEAR 1583

Query: 1438 RMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ 1497
               L Q +  Q +  D  + E W+  +   +++ D G    +   LI KH+   + + + 
Sbjct: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643

Query: 1498 EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFS 1557
               +  L   A  L       +  +   R  + ++ R L+     +  +L  +  L +F 
Sbjct: 1644 WSSMEELDQTAQTLTGPEVPEQQRVVQER--LREQLRALQELAATRDRELEGTLRLHEFL 1701

Query: 1558 RDVDEIEAWISEKLQTA--SDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVI 1615
            R+ ++++ W++ + Q A   +   +DP +      L    K   F+ ++   + R+    
Sbjct: 1702 REAEDLQGWLASQKQAAKGGESLGEDPEH-----ALHLCTKFAKFQHQVEMGSQRVAACR 1756

Query: 1616 DMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675
             +  SL+ERG  AG    V+ R   L   W  L + +  +   L++       +  + + 
Sbjct: 1757 LLAESLLERGHSAG--PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEV 1814

Query: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLM-TSSA 1734
               + E +A     +  +DL  +   L+ HQ LE ++   E +L++L   A  +      
Sbjct: 1815 LTQVQE-KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPG 1873

Query: 1735 FDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGS 1794
                 V+ ++  +   +  ++     RRA+L  +  L +F   + D  SW    +  +  
Sbjct: 1874 PQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQV 1933

Query: 1795 EDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFV 1854
            E+  ++ +        H+ L AEL A E   Q     G++         +E+Q+ L    
Sbjct: 1934 EESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQ 1993

Query: 1855 EHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL 1914
            +   ++ Q  A + +RL+   + Q F+      E  +  +   + +   G ++  ++ L+
Sbjct: 1994 DQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLI 2053

Query: 1915 KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRK 1974
            +KHE F    T  +D+           +++       +  ++  L  +   +++ A  R 
Sbjct: 2054 RKHEVFLKVLTA-QDKKEAALRERLKTLRR-----PRVRDRLPILLQRRMRVKELAESRG 2107

Query: 1975 AKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 2034
              L  +     F   A   E WI      LK      DL      L K + F+A +QA  
Sbjct: 2108 HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQA-H 2166

Query: 2035 QEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKV 2094
            +E + ++    + LLA  H ++  +  R   L K W  L    A R ++L + ++     
Sbjct: 2167 EEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRN----- 2221

Query: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSS---AQAD 2151
               FL F ++     +W +  E  +        LE    LR     FR + +      A 
Sbjct: 2222 ---FLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDAC 2278

Query: 2152 FNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKL 2211
               +++L  Q+K+     +P         EE      KII +R  +L         N   
Sbjct: 2279 IRSISDLSLQLKN----RDP---------EEV-----KIICQRRSQLNNRWASFHGNLLR 2320

Query: 2212 RQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATK---------RKHQ---- 2258
             Q+  + A   H   +E    L + +  ++E   L   L+  K         RKH+    
Sbjct: 2321 YQQQLEGALEIHVLSRE----LDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELER 2376

Query: 2259 EIRAMRSQLKKIE-DLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQI 2317
            E+  +++Q++ +E ++G   + +    +    H    +A+ W QL     + +  L+   
Sbjct: 2377 EVHPIQAQVESLEREVGRLCQRSPEAAHG-LRHRQQEVAESWWQLRSRAQKRREALDALH 2435

Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRL---------NHQEFKSCLRS 2359
            QA+    + +E L     +    D   + R           HQE K+ L S
Sbjct: 2436 QAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDS 2486



 Score =  289 bits (740), Expect = 2e-77
 Identities = 224/953 (23%), Positives = 433/953 (45%), Gaps = 22/953 (2%)

Query: 30   KELSTLR------RQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDP-TNLQGKL 82
            +ELS+L       + +L+ +   Q F    E++E+W+  K    + E   DP   ++  L
Sbjct: 2521 QELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLL 2580

Query: 83   QKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKG 142
             KH+  E +++  +G I  L+ T   +   GH  +++   R   +  + E L  +   + 
Sbjct: 2581 WKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRR 2640

Query: 143  IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE 202
             +L + ++L  +L++ ++V  W+ +K  +   E L         LQK+ + FQ ++ A  
Sbjct: 2641 HRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQ-QNFQAELDASM 2699

Query: 203  ERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNR 262
             +  E+ +   +L+Q  HP  E I+ + +E+ A W  L+  + ++  KL  A E  R  R
Sbjct: 2700 HQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRR 2759

Query: 263  DVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDK----VKALCAEA 318
             ++E  +W++  E  + +   G+ L  V  LL    G +R+L A  DK     +AL  +A
Sbjct: 2760 SMEELENWLEPIEVELRAPTVGQALPGVGELL----GTQRELEAAVDKKARQAEALLGQA 2815

Query: 319  DRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVT 378
                +     A  ++ +   L+  ++ +R    ER   L     L +F  D  +  +WV 
Sbjct: 2816 QAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQ 2875

Query: 379  EMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV 438
            E   L  A +    ++    L ++HQ  + E+ +HE   +    +G  L+ AGH+A+ EV
Sbjct: 2876 EKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEV 2935

Query: 439  REKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS 498
              ++  L +  A L      RR   +Q  + Q F  +  +  +W++++   L +ED+G S
Sbjct: 2936 AARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHS 2995

Query: 499  LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNAL 558
             ++ +ALL++ E  ++ L A   +I  L + A  L    +     V  +  A+      L
Sbjct: 2996 AEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAEL 3055

Query: 559  HERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNLQGKVQKHQAF 617
              RA  R   L +   L Q  R++  L +W+  K  TA  + Y +D   ++   +K  AF
Sbjct: 3056 LRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAF 3115

Query: 618  EAEL-SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
              E+ S  Q+++ AL K    L          + A+ + + + W++L +A + +   L  
Sbjct: 3116 RKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAA 3175

Query: 677  ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDG 736
            A++   F +   +++  + E    +  +D G  L++V+ LQ++H  LE ++ A +  +  
Sbjct: 3176 AHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVAR 3235

Query: 737  ITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE 796
            +  +A +           + K QEA    +  L+     R Q LA + +        ++ 
Sbjct: 3236 LQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGRCQEL 3291

Query: 797  ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHF 856
              W +E++ +A+S    +D+ G + LL +H+ L  EI     + + + Q+G  +V+  HF
Sbjct: 3292 LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHF 3351

Query: 857  AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGST 916
             + +V   L EL  + + L+   + R Q   +S   Q+      +AE+W+   E ++   
Sbjct: 3352 MSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKP 3411

Query: 917  DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
            DYG      E LL +H+ L   L+A       +++        + P + + G+
Sbjct: 3412 DYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGR 3464



 Score =  268 bits (684), Expect = 6e-71
 Identities = 200/833 (24%), Positives = 389/833 (46%), Gaps = 12/833 (1%)

Query: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
            A+    R Q +L R       +  RR +LE+  + Q F +D++E+  W++EK  +A +E 
Sbjct: 2615 AQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEG 2674

Query: 72   YKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
              D   L  +LQK Q F+AE+ A+     +L   G  ++  GH ASE I+ RL EL   W
Sbjct: 2675 LLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALW 2734

Query: 132  ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
              L +  ++K  KL +A + ++  R  E++ +W+   E  + +  +GQ L  V  L    
Sbjct: 2735 GELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQ 2794

Query: 192  EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLA---LQRQ 248
             E +  +     +   +   A   ++E H    L +  +++     QR K L     +R+
Sbjct: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHC---LAQDVEEQARRLLQRFKSLREPLQERR 2851

Query: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
              L   + + +F RD DE ++W++EK  L A+ D+G+ L++V+ L  +H+ LE ++++ E
Sbjct: 2852 TALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHE 2911

Query: 309  DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
               + +     +L Q+   +A ++  + ++L      +R  AA R   L  +   Q+FL 
Sbjct: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971

Query: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
            +  +  SW+ E   +++++++       +ALL R +  K +++A     +   ++   L 
Sbjct: 2972 ELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLE 3031

Query: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
            +  +  S +V  +L  + E  A LL   E R    ++ + L    R+T  +D W++ + A
Sbjct: 3032 SRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAA 3091

Query: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQEEKITALDEFATKLIQNNHYAMEDVATR 547
               ++D G  L+ V+ L +K + F K + S  + K+ AL + A  L +        +  +
Sbjct: 3092 TAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQ 3151

Query: 548  RDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTAT-DEAYKDPSN 606
            R  + +    L +    R   LA +  +  F + + EL+  + EK      ++     S+
Sbjct: 3152 RSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSS 3211

Query: 607  LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
            ++   Q+H+  E EL A +  +  L+    +L  ++  A   +A    +V   W  L   
Sbjct: 3212 VRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLA----KVQEAWATLQAK 3267

Query: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
             + +G  L +A Q   F    +++  W  E +   +S++  +D+   + L  +H  L  +
Sbjct: 3268 AQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQE 3327

Query: 727  VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
            +   + +   +  + +Q  D  HF +  + +  + L  R + L+E    R Q+ A+S  L
Sbjct: 3328 IRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGL 3387

Query: 787  QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR 839
            Q+L + +E  E W+   E +    + G  +  V+ LL +HQ L+  +A  E +
Sbjct: 3388 QKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEK 3440



 Score =  223 bits (569), Expect = 1e-57
 Identities = 158/519 (30%), Positives = 253/519 (48%), Gaps = 6/519 (1%)

Query: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
            A ++  R QQ+       +  +  RR  L+ +   Q F  +  E   W+ E+  +   E+
Sbjct: 2932 AHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSED 2991

Query: 72   YKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
                    Q  L++ +A + +++A S  I +L +T  L+ S  +  S  +  +L  +   
Sbjct: 2992 MGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREA 3051

Query: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
               LL +   +G  L +  +L Q  RE   +  W+  K A   S++ GQDLE V+VL++K
Sbjct: 3052 HAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEK 3111

Query: 191  FEEFQTDMAA-HEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
            F+ F+ ++ +  + +V  + + A  L +        I+ ++  + AAW+RL      R  
Sbjct: 3112 FDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171

Query: 250  KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
             L  A EV  F +   E    ++EK  LM  +D G  L+SV+ L ++H  LER+L A+E 
Sbjct: 3172 NLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEK 3231

Query: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
            +V  L  EA RL Q HP +   +   +E     W  ++  A ER   L  + +   FL  
Sbjct: 3232 EVARLQTEACRLGQLHPAAPGGLAKVQEA----WATLQAKAQERGQWLAQAAQGHAFLGR 3287

Query: 370  FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
             ++L +W  E + L +++ELA DVAGAE LL +H+E   EI       +   + GQ L+ 
Sbjct: 3288 CQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVD 3347

Query: 430  AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF 489
              H+ S EV E L  L      L E W LR Q+  +   LQ   +  EQ + W++  E  
Sbjct: 3348 NSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGL 3407

Query: 490  LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE 528
            LL  D G S+  VE LL +H+D EK L+AQEEK   + +
Sbjct: 3408 LLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQK 3446



 Score =  127 bits (320), Expect = 1e-28
 Identities = 137/569 (24%), Positives = 246/569 (43%), Gaps = 34/569 (5%)

Query: 1493 AINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL-KAQMIEKRS-----K 1546
            A  V E+++   Q    + +AA    +  I +  +       RL + Q +++R      +
Sbjct: 206  AFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQRRLTKILLQ 265

Query: 1547 LGESQTLQ-QFSRDVDEIEAWISEKLQTASDESYKD--PTNIQLSKLLS---------KH 1594
            L E++ LQ Q+ + V ++  WI+EK        + D  P   QL    +         + 
Sbjct: 266  LQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFRTQEKPPRL 325

Query: 1595 QKHQAFEAELHANADRIRG------VIDMGNSLIERGAC-AGSEDAVKARLAALADQWQF 1647
            Q+  A EA L      ++       +   G  L E   C AG E A  AR  AL    Q 
Sbjct: 326  QQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARSQALQ---QR 382

Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQL 1707
            L+Q    ++   +  +K     + +KD +  L +  A  AS      LA+V   +++  +
Sbjct: 383  LLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS------LATVEAAVQRLGM 436

Query: 1708 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE 1767
            LEA I   E R + L   AD L        + V  +++ +  R+Q++      +R ++ +
Sbjct: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496

Query: 1768 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
               +    ++++     ++E +    S   G+ L  V  L ++H  LEA+++AH   +  
Sbjct: 497  MQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHVSH 556

Query: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
            +     +L        E +Q +     +  + L  L  AR   LE++L+  +F+ N EEE
Sbjct: 557  LAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEE 616

Query: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH 1947
            EAW+ E    V +   G  L+ I G L+KH+A E +   H+    D+   G+DL  +   
Sbjct: 617  EAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPP 676

Query: 1948 HEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTD 2007
             + +   + + + G    L+     R A+L      LQ+   A    SW+ E+ +SL+  
Sbjct: 677  TQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERA 736

Query: 2008 DYGRDLSSVQTLLTKQETFDAGLQAFQQE 2036
              G+D ++ +TLL +    +  L+AF  E
Sbjct: 737  SCGQDQAAAETLLRRHVRLERVLRAFAAE 765



 Score =  123 bits (309), Expect = 2e-27
 Identities = 211/1120 (18%), Positives = 440/1120 (39%), Gaps = 125/1120 (11%)

Query: 1307 AEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
            ++ LQ++  +L Q   +L +R  Q KA L +S     FL D   ++         +++  
Sbjct: 376  SQALQQRLLQL-QRLETLARRF-QHKAALRES-----FLKDAEQVLDQARAPPASLAT-- 426

Query: 1367 LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEI-KQKLDILDQ 1425
                    EA ++R       I  + G FQA  +    L    +++  ++ +++ ++  +
Sbjct: 427  -------VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVR 479

Query: 1426 ERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIK 1485
             +  L+    QR+ + D    L L  ++ E A + +   +    +   G  L  V  L++
Sbjct: 480  WQRLLQHLQGQRKQVADMQAVLSLL-QEVEAASHQLEELQEPARSTACGQQLAEVVELLQ 538

Query: 1486 KHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRS 1545
            +H+  +  ++     ++ L     +L ++   +   + ++   +    + L A +  +R+
Sbjct: 539  RHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598

Query: 1546 KLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
             L ++    +F R+ +E EAW+ E  Q   + +        LS++    QKH+A EAE+H
Sbjct: 599  LLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAAL----GRDLSQIAGALQKHKALEAEVH 654

Query: 1606 ANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ 1665
             +      ++  G  L  R      +   +A   A+   WQ L  +   +  +L+ A   
Sbjct: 655  RHQAVCVDLVRRGRDLSARRPPTQPDPGERAE--AVQGGWQLLQTRVVGRGARLQTALLV 712

Query: 1666 QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
              +     +   WL E  + L     G+D A+   LL++H  LE  + A    L+ L  Q
Sbjct: 713  LQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQ 772

Query: 1726 AD------SLMTSSA---------------------------------------FDTSQV 1740
                    SL T ++                                       FD + +
Sbjct: 773  GRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTI 832

Query: 1741 KDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800
               +D ++  ++ ++++A  RRA+L E+  L  F     + + W++++ +L+       D
Sbjct: 833  LQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQAD 892

Query: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKEL 1860
               V  L  K++     LA  +     V  + ++L         +IQ++  +  + W +L
Sbjct: 893  TLEVMQL--KYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQL 950

Query: 1861 KQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG---DTLAAIQGLLKKH 1917
            + L   +  +L  S+E   F+      +  + + +  + +   G   DT  A+Q   KK 
Sbjct: 951  EALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKT 1010

Query: 1918 EAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKL 1977
               E        RV+ + +    + +      + +  +++ L G +  +++  AQR  + 
Sbjct: 1011 LVLER-------RVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQ 1063

Query: 1978 DENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
             E  A   F  ++  +  W    +  L++ +   D++S Q LL + +     +  + QE 
Sbjct: 1064 AETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLW-QER 1122

Query: 2038 IANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKL---LEAQSHFRKV 2094
            +  + A    + A     S+ +      L ++  +L      R++ L   LE Q   R+V
Sbjct: 1123 LQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREV 1182

Query: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQ 2154
            +    T A   +  +   +N  ED         + E  +L + H  F   LS+       
Sbjct: 1183 DGFTATCANHQAWLH--LDNLGED---------VREALSLLQQHREFGRLLSTLGPRAEA 1231

Query: 2155 L-AELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR- 2212
            L A  ++ ++S   A++      +++++  W  LQ          + EQRR++    L+ 
Sbjct: 1232 LRAHGEKLVQSQHPAAHTVR-EQLQSIQAQWTRLQG---------RSEQRRRQLLASLQL 1281

Query: 2213 QEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKR---KHQEIRAMRSQLKK 2269
            QE+ Q      QW++E            E SG   + L+  KR      E+ A R  ++ 
Sbjct: 1282 QEWKQDVAELMQWMEEKGLMAAH-----EPSGARRNILQTLKRHEAAESELLATRRHVEA 1336

Query: 2270 IEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA 2329
            ++ +G  +        +  +    GL  +W+ L++        L+Q  Q        ++A
Sbjct: 1337 LQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDA 1396

Query: 2330 LKEFSMMFKHFDKDKSG---------RLNHQEFKSCLRSL 2360
             ++   +       ++G         +  HQ+ +S  R+L
Sbjct: 1397 KEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTL 1436


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
            sapiens]
          Length = 2155

 Score =  609 bits (1570), Expect = e-173
 Identities = 402/1417 (28%), Positives = 707/1417 (49%), Gaps = 78/1417 (5%)

Query: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
            +E I+ER   + +++   ++LS +R+++LE++     FQ DA++++ W+ + L+I S  +
Sbjct: 699  SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 758

Query: 72   Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
               D  + Q  ++KH+    E+      +  L E  + +  E H  S  +R RL  +  +
Sbjct: 759  VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEER 817

Query: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
            ++ + E  R +   L     L +   E +    WI++KE  + + ++ + LE +EV+Q +
Sbjct: 818  YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 877

Query: 191  FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK 250
            FE  + +M     RV  VNQ A +L+   HP E+ IK +QD++N  W + + L  +++  
Sbjct: 878  FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 937

Query: 251  LFGAAEVQRFNRDVDETISWIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALED 309
            L  A  +Q ++ + +ET SWI+EK +++ S  D G DLA V AL RK  G+ERDL A+E 
Sbjct: 938  LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 997

Query: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
            K+  L  EA++L+  HP  A  I  +  E+   WE+++T    R A L ++ +LQ+FL D
Sbjct: 998  KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRD 1057

Query: 370  FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
              D  SW++  +  I ++++ + +  AE LL +H+  K EID +E+ ++   + G+ +  
Sbjct: 1058 LDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ 1117

Query: 430  AGHYASDE-VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
                A    +R++L  L      L ++WE R+    Q    Q F RDT+Q + +++ QE 
Sbjct: 1118 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1177

Query: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
             L + ++  +L+  EA +KK EDF  ++ A EEKI A+ E   +L+ + +   + +  + 
Sbjct: 1178 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1237

Query: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
            D++  R     E A     +L D+  LQ+F +D  EL  W+NEKM TA D +Y +  NL 
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1297

Query: 609  GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668
             K  KHQAF AEL++N+  +D +EK G +LI      +  V  ++  +  +W+ L   T+
Sbjct: 1298 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1357

Query: 669  LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728
             K  +L +AN+ + F ++  D++ WL+ +E  + SDDYGKDLT+V  L KK  +LE  + 
Sbjct: 1358 TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQME 1417

Query: 729  AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
              +  I+ +  QA+     G    + +  K+  +  ++  L EP+  RK  L  S  + Q
Sbjct: 1418 VRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ 1476

Query: 789  LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG- 847
              RDVEDE  W+ E+ P+A ST+ G +L  VQ L+KK+Q LQ EI GH+PRI  + ++  
Sbjct: 1477 FNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQ 1536

Query: 848  NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
            N + +    +AE ++ +L +L Q W  L  +  +R + LE++ +AQQY+ DA EAE+WM 
Sbjct: 1537 NIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1596

Query: 908  EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
            E+E  + S +  KDE SA ++LKKH+ L   +  Y  ++  L + +++      P  +  
Sbjct: 1597 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1656

Query: 968  G------KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYV 1021
                    +L   L D  E+  R   + +   L  LN         EV+D + ++    V
Sbjct: 1657 SMRQSKVDKLYAGLKDLAEE--RRGKLDERHRLFQLNR--------EVDDLEQWIAEREV 1706

Query: 1022 --KKLDPAQSASRENLLEEQ--------GSIALRQEQIDNQTRITKE--------AGSVS 1063
                 +  Q      +L+E+        G+I   QE++D    +  E        A +++
Sbjct: 1707 VAGSHELGQDYEHVTMLQERFREFARDTGNIG--QERVDTVNHLADELINSGHSDAATIA 1764

Query: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
                 + E +  LLEL + R  +L  S +    + +A E+   I +K   L  EE+G D 
Sbjct: 1765 EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQ 1823

Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
              VE LQ+    F+ D++A  ++++ + + A  L++     ++   +Q++E         
Sbjct: 1824 NTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQA-AYAGDKADDIQKRE--------- 1873

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
                                      E+ E W+SL    E R   L    +  RF     
Sbjct: 1874 -------------------------NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1908

Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
            +   W+E+  + +       D++SV+ L   H+G + ++ A  D   +  E  + L+   
Sbjct: 1909 DLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1968

Query: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
              ++E+++EK  +L +    +  + + R   L    ++ +F  D     +W+ G    +S
Sbjct: 1969 HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLS 2028

Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
            S E+ + V   E L++RH+            F A E+
Sbjct: 2029 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALER 2065



 Score =  565 bits (1455), Expect = e-160
 Identities = 403/1511 (26%), Positives = 737/1511 (48%), Gaps = 84/1511 (5%)

Query: 26   YHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDENY-KDPTNLQGKLQ 83
            Y    +L+  RR +LE+S R ++FF   AEE E WI+EK +I S ++Y KD T++   L 
Sbjct: 607  YQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEKILSSDDYGKDLTSVMRLLS 665

Query: 84   KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGI 143
            KH+AFE E+   SG   +  + G  MI+E HF SE IR R++ +  QW  L +    +  
Sbjct: 666  KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 725

Query: 144  KLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
            +L +A  L Q+  + +D+  W+ D   IV+S ++G D    + L KK ++   ++A +  
Sbjct: 726  RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 785

Query: 204  RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
             ++ +++ A+ L QE H E   ++ +   +   ++ +  L   R+  L     + +   +
Sbjct: 786  TLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 844

Query: 264  VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
             D    WI EKEQ + +      L  ++ +  + E LE ++     +V  +   A +L  
Sbjct: 845  ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 904

Query: 324  SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEM-KA 382
            S   S  +I+ ++++L T W Q R L   +   L  +  +Q +  +  +  SW+ E  K 
Sbjct: 905  SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 964

Query: 383  LINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKL 442
            + +  +L +D+AG  AL  +    + ++ A E       +  + L +     +  +  +L
Sbjct: 965  IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1024

Query: 443  TVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSV 502
              +S+    +    + R     +   LQ F RD +   +W+S+ +  + +ED+ ++L   
Sbjct: 1025 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEA 1084

Query: 503  EALLKKHEDFEKSLSAQEE---KITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALH 559
            E LL +HE+ +  +   EE   K+  + E  T+   +  Y    +  R  AL +  N LH
Sbjct: 1085 EKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMF--LRQRLQALDTGWNELH 1142

Query: 560  ERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGK---VQKHQA 616
            +    R+  L+ S   QQF RD+ + ++++N +           P+ L+G    ++K + 
Sbjct: 1143 KMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEM--PTTLEGAEAAIKKQED 1200

Query: 617  FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
            F   + AN+ +I+A+ + G++L+   +   D +  +++ +    +K  E      ++L++
Sbjct: 1201 FMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKD 1260

Query: 677  ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEADVAAHQDRID 735
                Q+F ++ +++ LW+ E    L + D   D   N+ +   KH    A++A++++ +D
Sbjct: 1261 NRDLQKFLQDCQELSLWINEKM--LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLD 1318

Query: 736  GITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED 795
             I  +  Q           +K+K   L   +E L+     + Q+L D+ + +   +   D
Sbjct: 1319 KIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCAD 1378

Query: 796  EETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGH 855
             + W+   E    S + GKDL  V  LLKK Q L+ ++   +  I+ +  +  A+ +EG 
Sbjct: 1379 LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1438

Query: 856  FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGS 915
             + ++V +K   +  K+  L    ++R+ +L  S +  Q+  D  +   W+ E+ P+  S
Sbjct: 1439 -STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATS 1497

Query: 916  TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC------------RQQVAPT 963
            TD+G +  + + L+KK++ L  ++  +   I  + E++Q+             RQ++A  
Sbjct: 1498 TDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADL 1557

Query: 964  DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKK 1023
                 K+L   L +  EK  R +           ++   + W  E       +     K 
Sbjct: 1558 -----KQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE--QELYMMSEEKAKD 1610

Query: 1024 LDPAQSASRENLLEEQG--SIALRQEQIDNQTRIT-----KEAGSVSLRMKQVEELYHSL 1076
               A S  +++ + EQ     A    Q+   +R        E+  +S+R  +V++LY  L
Sbjct: 1611 EQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGL 1670

Query: 1077 LELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDF 1136
             +L E+R+G L++  + F L RE ++L+QWI E+E    S E+G D E V +LQ++F +F
Sbjct: 1671 KDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREF 1730

Query: 1137 QKDL-KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSA 1195
             +D     + R+  +N +A++L + G                      +D+ T + WK  
Sbjct: 1731 ARDTGNIGQERVDTVNHLADELINSG---------------------HSDAATIAEWKDG 1769

Query: 1196 RLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQA 1255
                           LNE W  L +L + R+Q+L +++E+ +F+ DA E    I++K++ 
Sbjct: 1770 ---------------LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKK 1814

Query: 1256 LNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKC 1314
            L  +  G D  +V+ LQR H  FE D+ ALG +V  L E A RL  ++  + A+D+Q++ 
Sbjct: 1815 L-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRE 1873

Query: 1315 TELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGA 1374
             E+ +AW SL    + R+ +L D+ D  RF S  RDLM W+  +   + + E  +DV+  
Sbjct: 1874 NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1933

Query: 1375 EALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAW 1434
            E L+  HQ  + EIDAR  +F    + G+ LLA  HYAS EIK+KL  L ++R ++   W
Sbjct: 1934 ELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKW 1993

Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
              R   L   LE+  F RD   AE W+  +E +L++ + G S+D VE LIK+HE F+K+ 
Sbjct: 1994 EDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSA 2053

Query: 1495 NVQEEKIAALQ 1505
               +E+ +AL+
Sbjct: 2054 ATWDERFSALE 2064



 Score =  519 bits (1337), Expect = e-146
 Identities = 394/1716 (22%), Positives = 798/1716 (46%), Gaps = 82/1716 (4%)

Query: 35   LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYK-DPTNLQGKLQKHQAFEAEVQ 93
            +R++KLE   R   F R A   E W+ E  ++ S +N+  D   ++   +KH+A E ++ 
Sbjct: 402  IRQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIA 459

Query: 94   ANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ 153
            A    +  +      + +E +   + I  R   + R WE LLE +R +  +L     L +
Sbjct: 460  AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 519

Query: 154  YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAA 213
              +E   +MDW+++ + +V S++ G+ L  VE L +K    + D+    ERV  VN  A 
Sbjct: 520  IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQ 579

Query: 214  KLIQEQHP----EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS 269
            K   +       + ++I+ +   +   +Q L  LA +R+ +L  +  + +F  ++ E   
Sbjct: 580  KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG 639

Query: 270  WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSA 329
            WI+EKE++++SDD+G+DL SV  LL KH   E +++      +    E + +       +
Sbjct: 640  WIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGS 699

Query: 330  TQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADEL 389
             +I+ +   +   W  +  L+A R  RL ++  L +F AD  D+ +W+ ++  ++++ ++
Sbjct: 700  EKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV 759

Query: 390  ASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEER 449
              D    ++L+ +H++   EI  +  +  +  E   AL    H  S +VR +L+ + E  
Sbjct: 760  GHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERY 818

Query: 450  AALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKH 509
              + EL  LR+Q  +  + L   + + +  + W+ ++E +L N  + + L+ +E +  + 
Sbjct: 819  KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 878

Query: 510  EDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQL 569
            E  E  ++ Q  ++  +++ A +L+ + H + +++  ++D L +R +   E   R++  L
Sbjct: 879  ESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL 938

Query: 570  ADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKDPSNLQGKVQKHQAFEAELSANQSR 627
              +  +Q +  + +E KSW+ EK K   +T +   D + +    +K    E +L A +++
Sbjct: 939  LSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 998

Query: 628  IDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV 687
            +  L+K  +KL   +      + +R+ E+  +W+++    + +   L EA++ QQF R++
Sbjct: 999  LSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDL 1058

Query: 688  EDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
            +D + WL   +  +AS+D    LT  + L  +H  ++ ++  +++    +          
Sbjct: 1059 DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ- 1117

Query: 748  GHFDAEN--IKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
            G  DA+   ++++ +AL   +  L +    R+  L+ S   QQ  RD +  E ++  +E 
Sbjct: 1118 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1177

Query: 806  IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
            + A T     L G +  +KK +     +  +E +I AV + G  +V +G+  ++ ++ K+
Sbjct: 1178 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1237

Query: 866  HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA 925
              ++ +    +  AS+    L+D+   Q++  D  E   W+ EK        Y +  +  
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1297

Query: 926  EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDY------- 978
               LK H+A M++L++    +  + ++      +  P  +   KE +  L+         
Sbjct: 1298 SKWLK-HQAFMAELASNKEWLDKIEKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLEST 1355

Query: 979  -QEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSA-SRENLL 1036
             Q K+ R     K ++ T  +  + D W   +  +       Y K L        ++ +L
Sbjct: 1356 TQTKAQRLFDANKAELFTQ-SCADLDKWLHGLESQ--IQSDDYGKDLTSVNILLKKQQML 1412

Query: 1037 EEQGSIALRQ-EQIDNQTRITKEAGS----VSLRMKQVEELYHSLLELGEKRKGMLEKSC 1091
            E Q  +  ++ E++ +Q +   + G     V  +   V+  +  LLE   +RK  L  S 
Sbjct: 1413 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASK 1472

Query: 1092 KKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDIN 1151
            +     R+  +   W+ E+    TS + G +L+ V++L KK    QK+++ ++ R+ DI 
Sbjct: 1473 EIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1532

Query: 1152 KVAEDL--ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIK 1209
            + ++++  +S  L AE   A++Q+                                  + 
Sbjct: 1533 ERSQNIVTDSSSLSAE---AIRQR----------------------------------LA 1555

Query: 1210 ELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQ 1269
            +L + W  L +  E+R + L  AH  Q+++ DA E + W+ E+   + ++    D  S  
Sbjct: 1556 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1615

Query: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELNQAWSSLGKRA 1328
            ++ +KH+  E+ +    + V+ L +T+  L+  SHPES E +  + +++++ ++ L   A
Sbjct: 1616 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPES-ERISMRQSKVDKLYAGLKDLA 1674

Query: 1329 DQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEI 1388
            ++R+ KL + H L +   +  DL  WI     +  S EL +D      L ER +E   + 
Sbjct: 1675 EERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDT 1734

Query: 1389 -DARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLEL 1447
             +              +L+  GH  +  I +  D L++  ADL +    R  +L    EL
Sbjct: 1735 GNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYEL 1794

Query: 1448 QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAF 1507
              F+ D ++    +  +   L  E+ G   ++VE L + H  F+  I     ++  LQ  
Sbjct: 1795 HKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQED 1853

Query: 1508 ADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566
            A +L AA    K D I  R NEVL+ W+ L      +R +L ++    +F   V ++  W
Sbjct: 1854 AARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLW 1913

Query: 1567 ISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626
            + + ++    E+ + P ++   +LL  +  HQ  +AE+ A  D     I++G SL+ R  
Sbjct: 1914 MEDVIRQI--EAQEKPRDVSSVELLMNN--HQGIKAEIDARNDSFTTCIELGKSLLARKH 1969

Query: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686
             A  E  +K +L  L ++ + ++ K  ++ + L+   +   F+      + WL   E  L
Sbjct: 1970 YASEE--IKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2027

Query: 1687 ASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1722
            +S + G+ +  V  L+K+H+  E   +  ++R   L
Sbjct: 2028 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL 2063



 Score =  517 bits (1331), Expect = e-146
 Identities = 432/1940 (22%), Positives = 865/1940 (44%), Gaps = 139/1940 (7%)

Query: 372  DLTSWVTEMKALINADELASDVAGAEALLDRHQEH-----------KGEIDAHEDSFKS- 419
            DL  W+ +   ++N  + A+ + G +  L     +           KG ++    + +S 
Sbjct: 300  DLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSK 359

Query: 420  --ADESGQALLAAGHYASD--EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
              A+     +   G   SD  +  E+L     ER   L    +R+++ EQ    + F R 
Sbjct: 360  MRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLA--RRFDRK 417

Query: 476  TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
                + W+S+ +  +  ++ G  L +VEA  KKHE  E  ++A EE++ A+   A +L  
Sbjct: 418  AAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEA 477

Query: 536  NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT 595
             N++ ++ +  R+D ++     L E    RR +L  +  LQ+ F++   +  W++E    
Sbjct: 478  ENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVL 537

Query: 596  ATDEAY-KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAK----DEVA 650
               + Y K    ++  +QKH   EA++     R+  +  + QK        K      + 
Sbjct: 538  VLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR 597

Query: 651  ARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDL 710
             R+  +   +++L +    +  +L E+ +  +F   + + E W+ E E  L+SDDYGKDL
Sbjct: 598  DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 657

Query: 711  TNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALK 770
            T+V  L  KH   E +++      +    +        HF +E I+++   +  ++  L+
Sbjct: 658  TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLE 717

Query: 771  EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830
            +    RK++L ++  L Q   D +D + W+ +   I +S++ G D    Q+L+KKH+ + 
Sbjct: 718  QLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVA 777

Query: 831  AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890
             EIA + P +  + ++ +A+ +E H  + DV+ +L  + ++++ +      R+Q L+D+L
Sbjct: 778  EEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 836

Query: 891  QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
               + F++A+  E W+ EKE  + +    +  +  E +  + E+L  +++   S +  + 
Sbjct: 837  ALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 896

Query: 951  EQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVN 1010
            + A+       P++ E  K     L     +    V  KK  +L+ L+  N   + +E N
Sbjct: 897  QIARQLMHSGHPSEKEI-KAQQDKLNTRWSQFRELVDRKKDALLSALSIQN---YHLECN 952

Query: 1011 DRQGFVPAAYVKKLDPAQ----------SASRENLLEEQGSIALRQEQIDNQTRITK--- 1057
            + + ++     K ++  Q          +  R+    E+  +A+  +  D Q    K   
Sbjct: 953  ETKSWIREK-TKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLES 1011

Query: 1058 ----EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
                +A ++  R+ ++ +++  +    + R+  L ++ K     R+ ++ Q W++  + A
Sbjct: 1012 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTA 1071

Query: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
            + SE++   L + E L          L  +E+   +I+   ED +    M E V   Q  
Sbjct: 1072 IASEDMPNTLTEAEKL----------LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1121

Query: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
              Y  + +                          ++ L+  W  L ++ E R  LL  +H
Sbjct: 1122 AQYMFLRQ-------------------------RLQALDTGWNELHKMWENRQNLLSQSH 1156

Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
              Q+F RD  + + ++  +   L        L   +A  +K E F   + A  +K+N++ 
Sbjct: 1157 AYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVV 1216

Query: 1294 ETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMS 1353
            ET  RL+     +++ +QEK   ++       + A +   +L D+ DLQ+FL D ++L  
Sbjct: 1217 ETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSL 1276

Query: 1354 WINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYAS 1413
            WIN  + L + D    +     +   +HQ    E+ +        E+ G QL++      
Sbjct: 1277 WINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETE 1335

Query: 1414 PEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK 1473
              +K+KL  L +    LE     +   L    + +LF + C   + W+   E+ + ++D 
Sbjct: 1336 AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDY 1395

Query: 1474 GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRW 1533
            G  L SV  L+KK +  +  + V++++I  LQ+ A  L   G  +  ++ S+R  V  ++
Sbjct: 1396 GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKF 1454

Query: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
              L   + E++  L  S+ + QF+RDV++   W+ E++  A+   +    N+Q  +LL K
Sbjct: 1455 MELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH--NLQTVQLLIK 1512

Query: 1594 HQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSA 1653
              K+Q  + E+  +  RI  + +   +++   +   +E A++ RLA L   W  L++++ 
Sbjct: 1513 --KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE-AIRQRLADLKQLWGLLIEETE 1569

Query: 1654 EKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADIS 1713
            ++ ++L+EA++ Q +     + + W+SE E  + SE+  KD  S  ++LKKHQ+LE  + 
Sbjct: 1570 KRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVE 1629

Query: 1714 AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ 1773
             + + +  L+  + +L+  S  ++ ++  ++  ++  +  +K +A  RR KL+E HRL Q
Sbjct: 1630 DYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQ 1689

Query: 1774 FFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAI-QGVLDTG 1832
              R++DD E WI E++++ GS + G+D   V  L+++ +    E A     I Q  +DT 
Sbjct: 1690 LNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR----EFARDTGNIGQERVDTV 1745

Query: 1833 KKLSDDNTIGKEEIQQRLAQFV----EHWKELKQLAAARGQRLEESLEYQQFVANVEEEE 1888
              L+D+           +A++     E W +L +L   R Q L  S E  +F  + +E  
Sbjct: 1746 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIF 1805

Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHH 1948
              I +K   +  E+ G     ++ L + H  FE D      +V  +  +   L       
Sbjct: 1806 GRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGD 1864

Query: 1949 EENISSKMKG--LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKT 2006
            + +   K +   L    S L+   ++R   +D    F  F+   D++  W+ +    ++ 
Sbjct: 1865 KADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM-LWMEDVIRQIEA 1923

Query: 2007 DDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASL 2066
             +  RD+SSV+ L+   +   A + A + +       L   LLA KH  S+ I+ +   L
Sbjct: 1924 QEKPRDVSSVELLMNNHQGIKAEIDA-RNDSFTTCIELGKSLLARKHYASEEIKEKLLQL 1982

Query: 2067 MKRWSQLLANSAARKKKL-LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRC 2125
             ++  +++     R + L L  + H          F++ AS   +W    E  L+     
Sbjct: 1983 TEKRKEMIDKWEDRWEWLRLILEVH---------QFSRDASVAEAWLLGQEPYLSSREIG 2033

Query: 2126 NSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR 2185
             S++E++ L + H+AF  S ++    F+ L  L                 T+E LE    
Sbjct: 2034 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLT----------------TLELLE---- 2073

Query: 2186 NLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT 2245
                    R  + ++E++R+  + +   + ++ A +  QW       +       E+   
Sbjct: 2074 -------VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSP 2126

Query: 2246 LESQLEATKRKHQEIRAMRS 2265
              S    T + ++   + R+
Sbjct: 2127 RVSYRSQTYQNYKNFNSRRT 2146



 Score =  509 bits (1310), Expect = e-143
 Identities = 414/1901 (21%), Positives = 839/1901 (44%), Gaps = 122/1901 (6%)

Query: 216  IQEQHPEEELIKTKQDEVNAAWQRLKGLALQ--RQGKLFGAA-----EVQRFNRDVDETI 268
            I   HP+E+ I T        + ++K LA++  R GK+   A      ++++     + +
Sbjct: 243  ISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL 302

Query: 269  SWIKEKEQLMASDDFGRDLASVQALLRKHE---------------GLERDLAALEDKVKA 313
             WI++   ++ +  F   L  VQ  L+                   LE  L  ++ K++A
Sbjct: 303  EWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRA 362

Query: 314  LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ--------R 365
               +    ++   +S         ++   WE++     ER   L +    Q        R
Sbjct: 363  NNQKVYMPREGKLIS---------DINKAWERLEKAEHERELALRNELIRQEKLEQLARR 413

Query: 366  FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
            F        +W++E + L++ D    D+   EA   +H+  + +I A+E+  ++     +
Sbjct: 414  FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR 473

Query: 426  ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
             L A  ++    +  +   +      LLEL   RRQ+ E  + LQ  +++   + +WM +
Sbjct: 474  ELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDE 533

Query: 486  QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH-YAMEDV 544
             +  +L++D G  L  VE LL+KH   E  +  Q E++  ++  A K   +   Y   D 
Sbjct: 534  MKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDP 593

Query: 545  ATRRDALLSRR---NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY 601
               RD +         L + A  RRA+L +S  L +FF +  E + W+ EK K  + + Y
Sbjct: 594  QVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDY 653

Query: 602  -KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
             KD +++   + KH+AFE E+S      +   K G+ +I   H+  +++  R+  +   W
Sbjct: 654  GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQW 713

Query: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
              L + + ++  +L EA+   QF  + +DI+ W+ ++   ++S D G D  + Q+L KKH
Sbjct: 714  ANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH 773

Query: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
              +  ++A ++  +D +  QA       H ++ +++ +   +  RY+ + E    RKQ L
Sbjct: 774  KDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQAL 832

Query: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
             D+L L ++F + +  E WI EKE    +    + L  ++ +  + ++L+ E+     R+
Sbjct: 833  QDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRV 892

Query: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
              V Q    ++  GH + +++KA+  +LN +W   +    +++  L  +L  Q Y  + N
Sbjct: 893  AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECN 952

Query: 901  EAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
            E +SW+REK  ++ ST D G D     AL +K   +  DL A  + +  L+++A+    +
Sbjct: 953  ETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE 1012

Query: 960  VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVP-- 1017
                  +  + ++  L +  +      T  K    +L  ++    +  +++D Q ++   
Sbjct: 1013 ----HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1068

Query: 1018 -AAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL------------ 1064
              A   +  P      E LL +  +I    +  +   +  ++ G +              
Sbjct: 1069 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1128

Query: 1065 -RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
             R++ ++  ++ L ++ E R+ +L +S       R+  + + ++N +E  L   E+   L
Sbjct: 1129 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTL 1188

Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
            E  E   KK +DF   + ANE ++  + +    L S+G     + + + QE         
Sbjct: 1189 EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDG----NINSDRIQE--------- 1235

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
                                    +  +++R R  ++ A E    L    ++Q+F +D  
Sbjct: 1236 -----------------------KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ 1272

Query: 1244 ETKEWIEEKNQALNTDNYGHDLA-SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
            E   WI EK   L   +  +D A ++ +   KH+ F  +LA+  + ++ + +   +LI  
Sbjct: 1273 ELSLWINEK--MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE 1330

Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
             PE+   ++EK T L++ W  L      +  +L D++  + F     DL  W++G+   +
Sbjct: 1331 KPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQI 1390

Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422
             SD+  KD+T    LL++ Q    +++ R    +  +   Q L   G  ++ E+  K   
Sbjct: 1391 QSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLT 1449

Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482
            +  +  +L +   +R+  L    E+  F+RD E    W+  R     + D G +L +V+ 
Sbjct: 1450 VQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQL 1509

Query: 1483 LIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQMI 1541
            LIKK++   K I   + +I  +   +  ++        + I  R  ++   W  L  +  
Sbjct: 1510 LIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETE 1569

Query: 1542 EKRSKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQLSKLLSKHQKHQAF 1600
            ++  +L E+   QQ+  D  E EAW+SE+ L   S+E  KD  +      +S  +KHQ  
Sbjct: 1570 KRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSA-----VSMLKKHQIL 1624

Query: 1601 EAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLK 1660
            E  +   A+ +  +     +L+         + +  R + +   +  L   + E+  KL 
Sbjct: 1625 EQAVEDYAETVHQLSKTSRALVADSH--PESERISMRQSKVDKLYAGLKDLAEERRGKLD 1682

Query: 1661 EANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRL 1719
            E ++    N  + D + W++E E +  S + G+D   V  L ++ +    D  +  ++R+
Sbjct: 1683 ERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERV 1742

Query: 1720 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMD 1779
              +N  AD L+ S   D + + + +D +N  +  +  +  +R   L  S+ LH+F+ D  
Sbjct: 1743 DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAK 1802

Query: 1780 DEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN 1839
            +    I++K   +  E+ GRD   V+ L++ H   E ++ A    ++ + +   +L    
Sbjct: 1803 EIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAY 1861

Query: 1840 TIGK-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLV 1898
               K ++IQ+R  + +E WK L     +R  RL ++ +  +F + V +   W+ + +  +
Sbjct: 1862 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI 1921

Query: 1899 ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG 1958
             +++    +++++ L+  H+  + +     D        G+ L+ + ++  E I  K+  
Sbjct: 1922 EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1981

Query: 1959 LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQT 2018
            L  K  ++      R   L       QF+  A V E+W+  +E  L + + G+ +  V+ 
Sbjct: 1982 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEK 2041

Query: 2019 LLTKQETFDAGLQAFQQ--EGIANITALKDQLLAAKHVQSK 2057
            L+ + E F+     + +    +  +T L  +LL  +  Q +
Sbjct: 2042 LIKRHEAFEKSAATWDERFSALERLTTL--ELLEVRRQQEE 2080



 Score =  498 bits (1283), Expect = e-140
 Identities = 431/1843 (23%), Positives = 824/1843 (44%), Gaps = 126/1843 (6%)

Query: 146  LQAQKLVQ-YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQT--DMAAHE 202
            ++ +K+++ Y     D+++WI     I+ + +    L  V+   + F  ++T        
Sbjct: 285  IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 344

Query: 203  ERVN-EVNQFAAKLIQEQHPEEELIKTKQ---DEVNAAWQRL------KGLALQ----RQ 248
            E+ N EV  F  +     + ++  +  +     ++N AW+RL      + LAL+    RQ
Sbjct: 345  EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 404

Query: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
             KL   A  +RF+R      +W+ E ++L++ D+FG DL +V+A  +KHE +E D+AA E
Sbjct: 405  EKLEQLA--RRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYE 462

Query: 309  DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
            ++V+A+ A A  L+  +     +I  +++ +I  WE +  L   R  RL  +  LQ+   
Sbjct: 463  ERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQ 522

Query: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ--A 426
            +   +  W+ EMK L+ + +    + G E LL +H   + +I    +  +  + S Q  A
Sbjct: 523  EMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFA 582

Query: 427  LLAAGHYASDE--VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
                G+   D   +R+++  +      L +L   RR + E+   L  F+ +  + + W+ 
Sbjct: 583  TDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIR 642

Query: 485  KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
            ++E  L ++D G  L SV  LL KH  FE  +S +        +    +I   H+  E +
Sbjct: 643  EKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKI 702

Query: 545  ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKD 603
              R   +  +   L + +  R+ +L ++  L QF  D+D++ +W+ + +K  ++ +   D
Sbjct: 703  RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD 762

Query: 604  PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
              + Q  V+KH+    E++  +  +D L +    L    H    +V  R++ +   +K++
Sbjct: 763  EYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEV 821

Query: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
             E T L+   L++     +     +  ELW+ E E  L +    + L +++ +Q +   L
Sbjct: 822  AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESL 881

Query: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
            E ++     R+  +   ARQ   +GH   + IK +Q+ L  R+   +E +  +K  L  +
Sbjct: 882  EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSA 941

Query: 784  LRLQQLFRDVEDEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
            L +Q    +  + ++WIREK  +  ST + G DL GV  L +K   ++ ++   E ++  
Sbjct: 942  LSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSD 1001

Query: 843  VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
            + ++   +  E    A+ + ++L E++  WE +K     R   L ++ + QQ+  D ++ 
Sbjct: 1002 LQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDF 1061

Query: 903  ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE----------- 951
            +SW+   +  + S D       AE LL +HE + +++  Y    Q +R+           
Sbjct: 1062 QSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1121

Query: 952  -QAQSCRQQVAPTDD---------ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTN 1001
             Q    RQ++   D          E  + L+   + YQ+   R+    +      LN+  
Sbjct: 1122 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQ-FLRDTKQAE----AFLNNQE 1176

Query: 1002 KDWWKVEVNDRQGFVPAAYVKKLD--PAQSASRE--NLLEEQGSIALRQEQIDNQTRITK 1057
                  E+        AA  K+ D      A+ E  N + E G   +    I N  RI +
Sbjct: 1177 YVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNI-NSDRIQE 1235

Query: 1058 EAGSVSLRMKQVEELYHSLL-ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
            +  S+  R ++  E    LL  L + R        +KF+  ++  EL  WINEK   LT+
Sbjct: 1236 KVDSIDDRHRKNRETASELLMRLKDNR------DLQKFL--QDCQELSLWINEK--MLTA 1285

Query: 1117 EEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEV 1175
            +++  D    +     K   F  +L +N+  L  I K    L SE     E +AV ++++
Sbjct: 1286 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE---KPETEAVVKEKL 1342

Query: 1176 YGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEV 1235
             G                                 L++ W  L+   + ++Q L  A++ 
Sbjct: 1343 TG---------------------------------LHKMWEVLESTTQTKAQRLFDANKA 1369

Query: 1236 QRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGET 1295
            + F +   +  +W+      + +D+YG DL SV  L +K +  E  +     ++  L   
Sbjct: 1370 ELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1429

Query: 1296 AERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWI 1355
            A+ L Q   +S +++  K   +   +  L +  ++RK  L  S ++ +F  D  D + W+
Sbjct: 1430 AQALSQ-EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1488

Query: 1356 NGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE 1415
                 L +S +   ++   + L++++Q  + EI           +  Q ++      S E
Sbjct: 1489 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1548

Query: 1416 -IKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKG 1474
             I+Q+L  L Q    L +   +R   L++    Q ++ D  +AE WM+ +E ++ +E+K 
Sbjct: 1549 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1608

Query: 1475 DSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWR 1534
                S  +++KKH+  ++A+    E +  L   +  L+A  H     IS R+++V   + 
Sbjct: 1609 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1668

Query: 1535 RLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASD----ESYKDPTNIQLSKL 1590
             LK    E+R KL E   L Q +R+VD++E WI+E+   A      + Y+  T +Q    
Sbjct: 1669 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ---- 1724

Query: 1591 LSKHQKHQAFEAEL-HANADRIRGVIDMGNSLIERGACAGSEDAVKARLA-ALADQWQFL 1648
                ++ + F  +  +   +R+  V  + + LI  G    S+ A  A     L + W  L
Sbjct: 1725 ----ERFREFARDTGNIGQERVDTVNHLADELINSG---HSDAATIAEWKDGLNEAWADL 1777

Query: 1649 VQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLL 1708
            ++    ++Q L  + +   F    K+    + +    L  E+ G+D  +V  L + H   
Sbjct: 1778 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTF 1836

Query: 1709 EADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDT-INGRFQKIKSMAASRRAKLNE 1767
            E DI A   +++ L   A  L  + A D +    KR+  +   ++ +     SRR +L +
Sbjct: 1837 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1896

Query: 1768 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
            +    +FF  + D   W+++    + +++  RD++ V+ L   H+ ++AE+ A   +   
Sbjct: 1897 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1956

Query: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
             ++ GK L        EEI+++L Q  E  KE+      R + L   LE  QF  +    
Sbjct: 1957 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2016

Query: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDR 1930
            EAW+  +   ++S + G ++  ++ L+K+HEAFE       +R
Sbjct: 2017 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDER 2059



 Score =  414 bits (1063), Expect = e-115
 Identities = 355/1628 (21%), Positives = 714/1628 (43%), Gaps = 104/1628 (6%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIASDENYK 73
            I  R+  V+  +    EL   RRQ+LE +   Q   ++   +  W+ E K+ + S +  K
Sbjct: 486  ITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGK 545

Query: 74   DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS----ETIRTRLMELHR 129
                ++  LQKH   EA++   +  +  ++ +     ++G        + IR R+  +  
Sbjct: 546  HLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEF 605

Query: 130  QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
             ++ L +   E+  +L ++++L ++  E  +   WI +KE I++S++ G+DL  V  L  
Sbjct: 606  CYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLS 665

Query: 190  KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
            K   F+ +M+       +  +    +I E+H   E I+ +   +   W  L+ L+  R+ 
Sbjct: 666  KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 725

Query: 250  KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
            +L  A+ + +F  D D+  +W+ +  ++++S D G D  S Q+L++KH+ +  ++A    
Sbjct: 726  RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 785

Query: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
             +  L  +A  L Q H   +  ++ +   +   ++++  L   R   L D+  L +  ++
Sbjct: 786  TLDTLHEQASALPQEH-AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 844

Query: 370  FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
                  W+ E +  +N  ++   +   E +  R +  + E++         ++  + L+ 
Sbjct: 845  ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 904

Query: 430  AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM-SKQEA 488
            +GH +  E++ +   L+   +   EL + ++      + +Q ++ +  +  +W+  K + 
Sbjct: 905  SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 964

Query: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
                +DLG+ L  V AL +K    E+ L A E K++ L + A KL   +    + + +R 
Sbjct: 965  IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1024

Query: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
              +      +      R A L ++  LQQF RD D+ +SW++   +T T  A +D  N  
Sbjct: 1025 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS---RTQTAIASEDMPNTL 1081

Query: 609  GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE--------VAARMNEVISLW 660
             + +K       +   ++ ID  E+  QK+ D+               +  R+  + + W
Sbjct: 1082 TEAEKLLTQHENI---KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW 1138

Query: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
             +L +  E +   L +++  QQF R+ +  E +L   E  LA  +    L   +   KK 
Sbjct: 1139 NELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQ 1198

Query: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
                  + A++++I+ +    R+    G+ +++ I++K +++  R+   +E       +L
Sbjct: 1199 EDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRL 1258

Query: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
             D+  LQ+  +D ++   WI EK  + A      +   + +   KHQA  AE+A ++  +
Sbjct: 1259 KDNRDLQKFLQDCQELSLWINEK-MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWL 1317

Query: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
              + ++G  ++ E       VK KL  L++ WE L++    + Q L D+ +A+ +     
Sbjct: 1318 DKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1377

Query: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
            + + W+   E  + S DYGKD  S   LLKK + L + +      I+ L+ QAQ+  Q+ 
Sbjct: 1378 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG 1437

Query: 961  APTDDETGKELVLALYDYQEKSPREVTMKKGDILTL--LNSTNKD------WWKVEVNDR 1012
              TD+   K L +     +   P  +  +K ++L    ++  N+D      W    V +R
Sbjct: 1438 KSTDEVDSKRLTVQTKFMELLEP--LNERKHNLLASKEIHQFNRDVEDEILW----VGER 1491

Query: 1013 QGFVPAA-YVKKLDPAQSASRENLL---EEQGSIALRQEQIDNQTRITKEAGSVSL---- 1064
                 +  +   L   Q   ++N     E QG      +  +    I  ++ S+S     
Sbjct: 1492 MPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR 1551

Query: 1065 -RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
             R+  +++L+  L+E  EKR   LE++ +    + +A E + W++E+E  + SEE   D 
Sbjct: 1552 QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDE 1611

Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
            +    + KK    ++ ++     +  ++K +  L ++     E  +++Q +V        
Sbjct: 1612 QSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV-------- 1663

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
                                        ++ +  L+ LAEER   L   H + + +R+ D
Sbjct: 1664 ----------------------------DKLYAGLKDLAEERRGKLDERHRLFQLNREVD 1695

Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALG-DKVNSLGETAERLIQS 1302
            + ++WI E+     +   G D   V  LQ +   F RD   +G ++V+++   A+ LI S
Sbjct: 1696 DLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINS 1755

Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
                A  + E    LN+AW+ L +  D R   L  S++L +F  D +++   I   +   
Sbjct: 1756 GHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQD-KHKK 1814

Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA--HGHYASPEIKQKL 1420
              +EL +D    E L   H     +I A     +  ++   +L A   G  A    K++ 
Sbjct: 1815 LPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKREN 1874

Query: 1421 DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
            ++L+  ++ L+    +R  ++D   + + F         WM      +  ++K   + SV
Sbjct: 1875 EVLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VRDLMLWMEDVIRQIEAQEKPRDVSSV 1933

Query: 1481 EALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDI-------SSRRNEVLDRW 1533
            E L+  H+     I+ + +           L+A  HYA  +I       + +R E++D+W
Sbjct: 1934 ELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKW 1993

Query: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
                    ++   L     + QFSRD    EAW+  +    S        + ++ KL+  
Sbjct: 1994 E-------DRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD-EVEKLI-- 2043

Query: 1594 HQKHQAFE 1601
             ++H+AFE
Sbjct: 2044 -KRHEAFE 2050



 Score =  297 bits (760), Expect = 1e-79
 Identities = 181/542 (33%), Positives = 293/542 (54%), Gaps = 5/542 (0%)

Query: 11   TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK-LQIASD 69
            +AE I++R   +   +    E +  R ++LE+++R Q +  DA E E W+ E+ L + S+
Sbjct: 1546 SAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE 1605

Query: 70   ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
            E  KD  +    L+KHQ  E  V+  +  + +L +T   ++++ H  SE I  R  ++ +
Sbjct: 1606 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDK 1665

Query: 130  QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
             +  L +   E+  KL +  +L Q  RE +D+  WI ++E +  S ELGQD EHV +LQ+
Sbjct: 1666 LYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE 1725

Query: 190  KFEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
            +F EF  D     +ERV+ VN  A +LI   H +   I   +D +N AW  L  L   R 
Sbjct: 1726 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1785

Query: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
              L  + E+ +F  D  E    I++K + +  ++ GRD  +V+ L R H   E D+ AL 
Sbjct: 1786 QILAASYELHKFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALG 1844

Query: 309  DKVKALCAEADRLQQSHPLS-ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFL 367
             +V+ L  +A RLQ ++    A  IQ +  E++  W+ +      R  RL D+    RF 
Sbjct: 1845 TQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1904

Query: 368  ADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL 427
            +  RDL  W+ ++   I A E   DV+  E L++ HQ  K EIDA  DSF +  E G++L
Sbjct: 1905 SMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL 1964

Query: 428  LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487
            LA  HYAS+E++EKL  L+E+R  +++ WE R +     +++  F RD    + W+  QE
Sbjct: 1965 LARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQE 2024

Query: 488  AFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT-KLIQNNHYAMEDVAT 546
             +L + ++G S+D VE L+K+HE FEKS +  +E+ +AL+   T +L++      E+   
Sbjct: 2025 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2084

Query: 547  RR 548
            RR
Sbjct: 2085 RR 2086



 Score =  247 bits (631), Expect = 9e-65
 Identities = 179/742 (24%), Positives = 356/742 (47%), Gaps = 25/742 (3%)

Query: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIAS 68
            ET   ++E+   +   +   +  +  + Q+L D+ + + F +   +L+KW+   + QI S
Sbjct: 1333 ETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQS 1392

Query: 69   DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE------TIRT 122
            D+  KD T++   L+K Q  E +++     I +L      +  EG    E      T++T
Sbjct: 1393 DDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT 1452

Query: 123  RLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLE 182
            + ME       LLE + E+   LL ++++ Q+ R+ ED + W+ ++  + TS + G +L+
Sbjct: 1453 KFME-------LLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQ 1505

Query: 183  HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLK 241
             V++L KK +  Q ++  H+ R++++ + +  ++ +      E I+ +  ++   W  L 
Sbjct: 1506 TVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLI 1565

Query: 242  GLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLE 301
                +R  +L  A   Q++  D  E  +W+ E+E  M S++  +D  S  ++L+KH+ LE
Sbjct: 1566 EETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILE 1625

Query: 302  RDLAALEDKVKALCAEADRL-QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
            + +    + V  L   +  L   SHP  + +I +++ ++   +  ++ LA ER  +L++ 
Sbjct: 1626 QAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQSKVDKLYAGLKDLAEERRGKLDER 1684

Query: 361  YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEI-DAHEDSFKS 419
            +RL +   +  DL  W+ E + +  + EL  D      L +R +E   +  +  ++   +
Sbjct: 1685 HRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT 1744

Query: 420  ADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQV 479
             +     L+ +GH  +  + E    L+E  A LLEL + R Q      +L  FY D +++
Sbjct: 1745 VNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1804

Query: 480  DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHY 539
               +  +    L E+LG   ++VE L + H  FE  + A   ++  L E A +L     Y
Sbjct: 1805 FGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL--QAAY 1861

Query: 540  A---MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-T 595
            A    +D+  R + +L    +L +    RR +L D+    +FF    +L  W+ + ++  
Sbjct: 1862 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI 1921

Query: 596  ATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNE 655
               E  +D S+++  +  HQ  +AE+ A         + G+ L+   HYA +E+  ++ +
Sbjct: 1922 EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1981

Query: 656  VISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQN 715
            +    K++++  E +   LR   +  QF+R+    E WL   E +L+S + G+ +  V+ 
Sbjct: 1982 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEK 2041

Query: 716  LQKKHALLEADVAAHQDRIDGI 737
            L K+H   E   A   +R   +
Sbjct: 2042 LIKRHEAFEKSAATWDERFSAL 2063



 Score =  207 bits (526), Expect = 1e-52
 Identities = 153/651 (23%), Positives = 302/651 (46%), Gaps = 11/651 (1%)

Query: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA-S 68
            ++ +++  +R  V  ++    E    R+  L  S     F RD E+   W+ E++ +A S
Sbjct: 1438 KSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATS 1497

Query: 69   DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKL-DETGNLMISEGHFASETIRTRLMEL 127
             ++  +   +Q  ++K+Q  + E+Q +   I  + + + N++      ++E IR RL +L
Sbjct: 1498 TDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADL 1557

Query: 128  HRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVL 187
             + W LL+E+  ++  +L +A +  QY  +  +   W++++E  + SEE  +D +    +
Sbjct: 1558 KQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSM 1617

Query: 188  QKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQR 247
             KK +  +  +  + E V+++++ +  L+ + HPE E I  +Q +V+  +  LK LA +R
Sbjct: 1618 LKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEER 1677

Query: 248  QGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAAL 307
            +GKL     + + NR+VD+   WI E+E +  S + G+D   V  L  +     RD   +
Sbjct: 1678 RGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI 1737

Query: 308  -EDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRF 366
             +++V  +   AD L  S    A  I   ++ L   W  +  L   R   L  SY L +F
Sbjct: 1738 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKF 1797

Query: 367  LADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQA 426
              D +++   + +    +  +EL  D    E L   H   + +I A     +   E    
Sbjct: 1798 YHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAAR 1856

Query: 427  LLAAGHYA---SDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM 483
            L AA  YA   +D+++++   + E   +LL+  E RR +     D   F+     +  WM
Sbjct: 1857 LQAA--YAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWM 1914

Query: 484  SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
                  +  ++    + SVE L+  H+  +  + A+ +  T   E    L+   HYA E+
Sbjct: 1915 EDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEE 1974

Query: 544  VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSW-VNEKMKTATDEAYK 602
            +  +   L  +R  + ++   R   L     + QF RD+   ++W + ++   ++ E  +
Sbjct: 1975 IKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQ 2034

Query: 603  DPSNLQGKVQKHQAFEAELSANQSRIDALEK-AGQKLIDVNHYAKDEVAAR 652
                ++  +++H+AFE   +    R  ALE+    +L++V    ++E   R
Sbjct: 2035 SVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKR 2085



 Score = 98.2 bits (243), Expect = 9e-20
 Identities = 128/611 (20%), Positives = 244/611 (39%), Gaps = 86/611 (14%)

Query: 1751 FQKIKSMAASRRA------KLNESHRLHQFFRDM-DDEESWIKEKKLLVGSEDYGRDLTG 1803
            F K+K++A   +          E+ ++ + +  +  D   WI++  +++ +  +   L G
Sbjct: 264  FSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG 323

Query: 1804 VQ----------------------NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTI 1841
            VQ                      NL      +++++ A+   +    + GK +SD N  
Sbjct: 324  VQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE-GKLISDIN-- 380

Query: 1842 GKEEIQQRLAQFVEHWKELKQLAAARGQRL-EESLEY--QQFVANVEEEEAWINEKMTLV 1898
               +  +RL +  EH +EL    A R + + +E LE   ++F       E W++E   LV
Sbjct: 381  ---KAWERLEK-AEHEREL----ALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLV 432

Query: 1899 ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG 1958
            + +++G  L A++   KKHEA ETD   +++RV  V    ++L  +N H  + I+++   
Sbjct: 433  SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 492

Query: 1959 LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQT 2018
            +      L +    R+ +L+ N    +   +   +  W+ E +  + + DYG+ L  V+ 
Sbjct: 493  VIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVED 552

Query: 2019 LLTKQETFDA--GLQAFQQEGI-ANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLA 2075
            LL K    +A  G+QA +  G+ A+           K    + I  R A +   + +L  
Sbjct: 553  LLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ 612

Query: 2076 NSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALR 2135
             +A R+ +L E+    R++   F   A++      W    E+ L+       L  +  L 
Sbjct: 613  LAAERRARLEES----RRLWKFFWEMAEE----EGWIREKEKILSSDDYGKDLTSVMRLL 664

Query: 2136 EAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERE 2195
              H AF   +S     F Q  +    + +     +      +  + E W NL+++   R+
Sbjct: 665  SKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRK 724

Query: 2196 LELQKEQRRQEENDKLRQEFAQHANAFHQWIQE----------------TRTYLLDGSCM 2239
              L        E   L  +F   A+    W+ +                T++ +     +
Sbjct: 725  KRL--------EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDV 776

Query: 2240 VEESG-------TLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHST 2292
             EE         TL  Q  A  ++H E   +R +L  IE+    + E   L  K     T
Sbjct: 777  AEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL-RKQALQDT 835

Query: 2293 VGLAQQWDQLD 2303
            + L + + + D
Sbjct: 836  LALYKMFSEAD 846



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 61/296 (20%), Positives = 119/296 (40%), Gaps = 18/296 (6%)

Query: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
            A Q  G+  +   +D  ++  H   K+I     +    +S++ A  A   K++ +   + 
Sbjct: 228  AEQHLGLTKLLDPED--ISVDHPDEKSIITYVVTYYHYFSKMKA-LAVEGKRIGKVLDNA 284

Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQ-A 2150
             + E +   +   AS    W E     L +    NSL  ++   +A + +R+     +  
Sbjct: 285  IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 344

Query: 2151 DFNQLAELDRQIKSFRVASNPYTWFTMEA-----LEETWRNLQKIIKERELELQKEQRRQ 2205
            +   L  L   I+S   A+N   +   E      + + W  L+K   EREL L+ E  RQ
Sbjct: 345  EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 404

Query: 2206 EENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ----EIR 2261
            E+ ++L + F + A     W+ E +  +       +  G     +EA  +KH+    +I 
Sbjct: 405  EKLEQLARRFDRKAAMRETWLSENQRLVSQ-----DNFGFDLPAVEAATKKHEAIETDIA 459

Query: 2262 AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQI 2317
            A   +++ +  +   +E     D K        + + W+ L +L    +  LE  +
Sbjct: 460  AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNL 515


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score =  609 bits (1570), Expect = e-173
 Identities = 402/1417 (28%), Positives = 707/1417 (49%), Gaps = 78/1417 (5%)

Query: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDEN 71
            +E I+ER   + +++   ++LS +R+++LE++     FQ DA++++ W+ + L+I S  +
Sbjct: 712  SEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771

Query: 72   Y-KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
               D  + Q  ++KH+    E+      +  L E  + +  E H  S  +R RL  +  +
Sbjct: 772  VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEER 830

Query: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
            ++ + E  R +   L     L +   E +    WI++KE  + + ++ + LE +EV+Q +
Sbjct: 831  YKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHR 890

Query: 191  FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK 250
            FE  + +M     RV  VNQ A +L+   HP E+ IK +QD++N  W + + L  +++  
Sbjct: 891  FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 950

Query: 251  LFGAAEVQRFNRDVDETISWIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALED 309
            L  A  +Q ++ + +ET SWI+EK +++ S  D G DLA V AL RK  G+ERDL A+E 
Sbjct: 951  LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 1010

Query: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
            K+  L  EA++L+  HP  A  I  +  E+   WE+++T    R A L ++ +LQ+FL D
Sbjct: 1011 KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRD 1070

Query: 370  FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
              D  SW++  +  I ++++ + +  AE LL +H+  K EID +E+ ++   + G+ +  
Sbjct: 1071 LDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ 1130

Query: 430  AGHYASDE-VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
                A    +R++L  L      L ++WE R+    Q    Q F RDT+Q + +++ QE 
Sbjct: 1131 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1190

Query: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
             L + ++  +L+  EA +KK EDF  ++ A EEKI A+ E   +L+ + +   + +  + 
Sbjct: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250

Query: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
            D++  R     E A     +L D+  LQ+F +D  EL  W+NEKM TA D +Y +  NL 
Sbjct: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310

Query: 609  GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE 668
             K  KHQAF AEL++N+  +D +EK G +LI      +  V  ++  +  +W+ L   T+
Sbjct: 1311 SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ 1370

Query: 669  LKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVA 728
             K  +L +AN+ + F ++  D++ WL+ +E  + SDDYGKDLT+V  L KK  +LE  + 
Sbjct: 1371 TKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQME 1430

Query: 729  AHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
              +  I+ +  QA+     G    + +  K+  +  ++  L EP+  RK  L  S  + Q
Sbjct: 1431 VRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ 1489

Query: 789  LFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG- 847
              RDVEDE  W+ E+ P+A ST+ G +L  VQ L+KK+Q LQ EI GH+PRI  + ++  
Sbjct: 1490 FNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQ 1549

Query: 848  NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
            N + +    +AE ++ +L +L Q W  L  +  +R + LE++ +AQQY+ DA EAE+WM 
Sbjct: 1550 NIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMS 1609

Query: 908  EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
            E+E  + S +  KDE SA ++LKKH+ L   +  Y  ++  L + +++      P  +  
Sbjct: 1610 EQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERI 1669

Query: 968  G------KELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYV 1021
                    +L   L D  E+  R   + +   L  LN         EV+D + ++    V
Sbjct: 1670 SMRQSKVDKLYAGLKDLAEE--RRGKLDERHRLFQLNR--------EVDDLEQWIAEREV 1719

Query: 1022 --KKLDPAQSASRENLLEEQ--------GSIALRQEQIDNQTRITKE--------AGSVS 1063
                 +  Q      +L+E+        G+I   QE++D    +  E        A +++
Sbjct: 1720 VAGSHELGQDYEHVTMLQERFREFARDTGNIG--QERVDTVNHLADELINSGHSDAATIA 1777

Query: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
                 + E +  LLEL + R  +L  S +    + +A E+   I +K   L  EE+G D 
Sbjct: 1778 EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQ 1836

Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
              VE LQ+    F+ D++A  ++++ + + A  L++     ++   +Q++E         
Sbjct: 1837 NTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQA-AYAGDKADDIQKRE--------- 1886

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
                                      E+ E W+SL    E R   L    +  RF     
Sbjct: 1887 -------------------------NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1921

Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
            +   W+E+  + +       D++SV+ L   H+G + ++ A  D   +  E  + L+   
Sbjct: 1922 DLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981

Query: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
              ++E+++EK  +L +    +  + + R   L    ++ +F  D     +W+ G    +S
Sbjct: 1982 HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLS 2041

Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
            S E+ + V   E L++RH+            F A E+
Sbjct: 2042 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALER 2078



 Score =  565 bits (1455), Expect = e-160
 Identities = 403/1511 (26%), Positives = 737/1511 (48%), Gaps = 84/1511 (5%)

Query: 26   YHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIASDENY-KDPTNLQGKLQ 83
            Y    +L+  RR +LE+S R ++FF   AEE E WI+EK +I S ++Y KD T++   L 
Sbjct: 620  YQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEKILSSDDYGKDLTSVMRLLS 678

Query: 84   KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGI 143
            KH+AFE E+   SG   +  + G  MI+E HF SE IR R++ +  QW  L +    +  
Sbjct: 679  KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738

Query: 144  KLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE 203
            +L +A  L Q+  + +D+  W+ D   IV+S ++G D    + L KK ++   ++A +  
Sbjct: 739  RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798

Query: 204  RVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRD 263
             ++ +++ A+ L QE H E   ++ +   +   ++ +  L   R+  L     + +   +
Sbjct: 799  TLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857

Query: 264  VDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQ 323
             D    WI EKEQ + +      L  ++ +  + E LE ++     +V  +   A +L  
Sbjct: 858  ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 917

Query: 324  SHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEM-KA 382
            S   S  +I+ ++++L T W Q R L   +   L  +  +Q +  +  +  SW+ E  K 
Sbjct: 918  SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 977

Query: 383  LINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKL 442
            + +  +L +D+AG  AL  +    + ++ A E       +  + L +     +  +  +L
Sbjct: 978  IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1037

Query: 443  TVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSV 502
              +S+    +    + R     +   LQ F RD +   +W+S+ +  + +ED+ ++L   
Sbjct: 1038 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEA 1097

Query: 503  EALLKKHEDFEKSLSAQEE---KITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALH 559
            E LL +HE+ +  +   EE   K+  + E  T+   +  Y    +  R  AL +  N LH
Sbjct: 1098 EKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMF--LRQRLQALDTGWNELH 1155

Query: 560  ERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGK---VQKHQA 616
            +    R+  L+ S   QQF RD+ + ++++N +           P+ L+G    ++K + 
Sbjct: 1156 KMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEM--PTTLEGAEAAIKKQED 1213

Query: 617  FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLRE 676
            F   + AN+ +I+A+ + G++L+   +   D +  +++ +    +K  E      ++L++
Sbjct: 1214 FMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKD 1273

Query: 677  ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEADVAAHQDRID 735
                Q+F ++ +++ LW+ E    L + D   D   N+ +   KH    A++A++++ +D
Sbjct: 1274 NRDLQKFLQDCQELSLWINEKM--LTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLD 1331

Query: 736  GITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED 795
             I  +  Q           +K+K   L   +E L+     + Q+L D+ + +   +   D
Sbjct: 1332 KIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCAD 1391

Query: 796  EETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGH 855
             + W+   E    S + GKDL  V  LLKK Q L+ ++   +  I+ +  +  A+ +EG 
Sbjct: 1392 LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1451

Query: 856  FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGS 915
             + ++V +K   +  K+  L    ++R+ +L  S +  Q+  D  +   W+ E+ P+  S
Sbjct: 1452 -STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATS 1510

Query: 916  TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC------------RQQVAPT 963
            TD+G +  + + L+KK++ L  ++  +   I  + E++Q+             RQ++A  
Sbjct: 1511 TDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADL 1570

Query: 964  DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKK 1023
                 K+L   L +  EK  R +           ++   + W  E       +     K 
Sbjct: 1571 -----KQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE--QELYMMSEEKAKD 1623

Query: 1024 LDPAQSASRENLLEEQG--SIALRQEQIDNQTRIT-----KEAGSVSLRMKQVEELYHSL 1076
               A S  +++ + EQ     A    Q+   +R        E+  +S+R  +V++LY  L
Sbjct: 1624 EQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGL 1683

Query: 1077 LELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDF 1136
             +L E+R+G L++  + F L RE ++L+QWI E+E    S E+G D E V +LQ++F +F
Sbjct: 1684 KDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREF 1743

Query: 1137 QKDL-KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSA 1195
             +D     + R+  +N +A++L + G                      +D+ T + WK  
Sbjct: 1744 ARDTGNIGQERVDTVNHLADELINSG---------------------HSDAATIAEWKDG 1782

Query: 1196 RLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQA 1255
                           LNE W  L +L + R+Q+L +++E+ +F+ DA E    I++K++ 
Sbjct: 1783 ---------------LNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKK 1827

Query: 1256 LNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKC 1314
            L  +  G D  +V+ LQR H  FE D+ ALG +V  L E A RL  ++  + A+D+Q++ 
Sbjct: 1828 L-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRE 1886

Query: 1315 TELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGA 1374
             E+ +AW SL    + R+ +L D+ D  RF S  RDLM W+  +   + + E  +DV+  
Sbjct: 1887 NEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSV 1946

Query: 1375 EALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAW 1434
            E L+  HQ  + EIDAR  +F    + G+ LLA  HYAS EIK+KL  L ++R ++   W
Sbjct: 1947 ELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKW 2006

Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAI 1494
              R   L   LE+  F RD   AE W+  +E +L++ + G S+D VE LIK+HE F+K+ 
Sbjct: 2007 EDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSA 2066

Query: 1495 NVQEEKIAALQ 1505
               +E+ +AL+
Sbjct: 2067 ATWDERFSALE 2077



 Score =  527 bits (1357), Expect = e-149
 Identities = 409/1739 (23%), Positives = 806/1739 (46%), Gaps = 117/1739 (6%)

Query: 557  ALHERAMRRRAQLADSFHLQQFFRDSDEL----KSWVNEKMKTATDEAYK-DPSNLQGKV 611
            A HER +  R +L     L+Q  R  D      ++W++E  +  + + +  D   ++   
Sbjct: 402  AEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT 461

Query: 612  QKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKG 671
            +KH+A E +++A + R+ A+    ++L   N++    + AR + VI LW+ LLE    + 
Sbjct: 462  KKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARR 521

Query: 672  IKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
             +L      Q+  + +  I  W+ E++  + S DYGK L  V++L +KH L+EAD+    
Sbjct: 522  QRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQA 581

Query: 732  DRIDGITIQARQFQDAGH----FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
            +R+ G+   A++F   G      D + I+ +   +   Y+ L +    R+ +L +S RL 
Sbjct: 582  ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLW 641

Query: 788  QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
            + F ++ +EE WIREKE I +S + GKDL  V  LL KH+A + E++G     +   ++G
Sbjct: 642  KFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 701

Query: 848  NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
              M+ E HF +E ++ ++  + ++W  L+  ++ R++ LE++    Q+ ADA++ ++WM 
Sbjct: 702  EDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWML 761

Query: 908  EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDET 967
            +   IV S+D G DE S ++L+KKH+ +  +++ Y  ++  L EQA +  Q+ A + D  
Sbjct: 762  DILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVR 821

Query: 968  GKELVLALYDYQEKSPREVTMKK----GDILTLLNS-TNKDWWKVEVNDRQGFVPAAYV- 1021
            G+   L+  + + K   E+T  +     D L L    +  D  ++ +++++ ++    + 
Sbjct: 822  GR---LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIP 878

Query: 1022 KKLDPAQSASR--ENLLEEQGSIALRQEQIDNQTRITKEAG-----SVSLRMKQVEELYH 1074
            +KL+  +      E+L  E  + A R   ++   R    +G      +  +  ++   + 
Sbjct: 879  EKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWS 938

Query: 1075 SLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS-EEVGADLEQVEVLQKKF 1133
               EL +++K  L  +        E NE + WI EK   + S +++G DL  V  LQ+K 
Sbjct: 939  QFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL 998

Query: 1134 DDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWK 1193
               ++DL A E++L D+ K AE LESE    ++ QA+                       
Sbjct: 999  TGMERDLVAIEAKLSDLQKEAEKLESE--HPDQAQAI----------------------- 1033

Query: 1194 SARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKN 1253
                        + + E+++ W  ++   + R   LG A ++Q+F RD D+ + W+    
Sbjct: 1034 -----------LSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQ 1082

Query: 1254 QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESA-EDLQE 1312
             A+ +++  + L   + L  +HE  + ++    +    + +  E + Q   ++    L++
Sbjct: 1083 TAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQ 1142

Query: 1313 KCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVT 1372
            +   L+  W+ L K  + R+  L  SH  Q+FL D +   +++N    +++  E+   + 
Sbjct: 1143 RLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLE 1202

Query: 1373 GAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEK 1432
            GAEA +++ ++  T +DA      A  + G++L++ G+  S  I++K+D +D       +
Sbjct: 1203 GAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE 1262

Query: 1433 AWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKG-DSLDSVEALIKKHEDFD 1491
               +  M L    +LQ F +DC++   W+   E  L  +D   D   ++ +   KH+ F 
Sbjct: 1263 TASELLMRLKDNRDLQKFLQDCQELSLWI--NEKMLTAQDMSYDEARNLHSKWLKHQAFM 1320

Query: 1492 KAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQ 1551
              +   +E +  ++    QLI+     +  +  +   +   W  L++    K  +L ++ 
Sbjct: 1321 AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN 1380

Query: 1552 TLQQFSRDVDEIEAWI-SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADR 1610
              + F++   +++ W+   + Q  SD+  KD T++ +  LL   +K Q  E ++      
Sbjct: 1381 KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNI--LL---KKQQMLENQMEVRKKE 1435

Query: 1611 IRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNT 1670
            I  +     +L + G    S D V ++   +  ++  L++   E+   L  + +   FN 
Sbjct: 1436 IEELQSQAQALSQEGK---STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNR 1492

Query: 1671 GIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLM 1730
             ++D   W+ E   L  S D+G +L +V  L+KK+Q L+ +I  H+ R+ D+  ++ +++
Sbjct: 1493 DVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIV 1552

Query: 1731 T-SSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKK 1789
            T SS+     ++ +   +   +  +      R  +L E+HR  Q++ D  + E+W+ E++
Sbjct: 1553 TDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQE 1612

Query: 1790 LLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQR 1849
            L + SE+  +D     ++ KKH+ LE  +  +   +  +  T + L  D+    E I  R
Sbjct: 1613 LYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMR 1672

Query: 1850 LAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAA 1909
             ++  + +  LK LA  R  +L+E     Q    V++ E WI E+  +  S + G     
Sbjct: 1673 QSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEH 1732

Query: 1910 IQGLLKKHEAFETDF-TVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEK 1968
            +  L ++   F  D   + ++RV+ V     +LI   +     I+    GLN   +DL +
Sbjct: 1733 VTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLE 1792

Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
                R   L  +    +F   A  +   I +K   L  ++ GRD ++V+TL     TF+ 
Sbjct: 1793 LIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEH 1851

Query: 2029 GLQAFQQEGIANITALKDQL--LAAKHVQSKA--IEARHASLMKRWSQLLANSAARKKKL 2084
             +QA   +    +  L++    L A +   KA  I+ R   +++ W  LL    +R+ +L
Sbjct: 1852 DIQALGTQ----VRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRL 1907

Query: 2085 LEAQSHFR---KVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAF 2141
            ++    FR    V DL L           W E+    +    +   +  ++ L   H   
Sbjct: 1908 VDTGDKFRFFSMVRDLML-----------WMEDVIRQIEAQEKPRDVSSVELLMNNHQGI 1956

Query: 2142 RSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKE 2201
            ++ + +    F    EL + +    +A   Y      A EE    L ++ ++R+  + K 
Sbjct: 1957 KAEIDARNDSFTTCIELGKSL----LARKHY------ASEEIKEKLLQLTEKRKEMIDKW 2006

Query: 2202 QRRQEENDKLRQ--EFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
            + R E    + +  +F++ A+    W+     YL        E G    ++E   ++H+
Sbjct: 2007 EDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSS-----REIGQSVDEVEKLIKRHE 2060



 Score =  519 bits (1337), Expect = e-146
 Identities = 394/1716 (22%), Positives = 798/1716 (46%), Gaps = 82/1716 (4%)

Query: 35   LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYK-DPTNLQGKLQKHQAFEAEVQ 93
            +R++KLE   R   F R A   E W+ E  ++ S +N+  D   ++   +KH+A E ++ 
Sbjct: 415  IRQEKLEQLARR--FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIA 472

Query: 94   ANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ 153
            A    +  +      + +E +   + I  R   + R WE LLE +R +  +L     L +
Sbjct: 473  AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 532

Query: 154  YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAA 213
              +E   +MDW+++ + +V S++ G+ L  VE L +K    + D+    ERV  VN  A 
Sbjct: 533  IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQ 592

Query: 214  KLIQEQHP----EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS 269
            K   +       + ++I+ +   +   +Q L  LA +R+ +L  +  + +F  ++ E   
Sbjct: 593  KFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG 652

Query: 270  WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSA 329
            WI+EKE++++SDD+G+DL SV  LL KH   E +++      +    E + +       +
Sbjct: 653  WIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGS 712

Query: 330  TQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADEL 389
             +I+ +   +   W  +  L+A R  RL ++  L +F AD  D+ +W+ ++  ++++ ++
Sbjct: 713  EKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDV 772

Query: 390  ASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEER 449
              D    ++L+ +H++   EI  +  +  +  E   AL    H  S +VR +L+ + E  
Sbjct: 773  GHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERY 831

Query: 450  AALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKH 509
              + EL  LR+Q  +  + L   + + +  + W+ ++E +L N  + + L+ +E +  + 
Sbjct: 832  KEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF 891

Query: 510  EDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQL 569
            E  E  ++ Q  ++  +++ A +L+ + H + +++  ++D L +R +   E   R++  L
Sbjct: 892  ESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL 951

Query: 570  ADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKDPSNLQGKVQKHQAFEAELSANQSR 627
              +  +Q +  + +E KSW+ EK K   +T +   D + +    +K    E +L A +++
Sbjct: 952  LSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011

Query: 628  IDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV 687
            +  L+K  +KL   +      + +R+ E+  +W+++    + +   L EA++ QQF R++
Sbjct: 1012 LSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDL 1071

Query: 688  EDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
            +D + WL   +  +AS+D    LT  + L  +H  ++ ++  +++    +          
Sbjct: 1072 DDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQ- 1130

Query: 748  GHFDAEN--IKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
            G  DA+   ++++ +AL   +  L +    R+  L+ S   QQ  RD +  E ++  +E 
Sbjct: 1131 GQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEY 1190

Query: 806  IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
            + A T     L G +  +KK +     +  +E +I AV + G  +V +G+  ++ ++ K+
Sbjct: 1191 VLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKV 1250

Query: 866  HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA 925
              ++ +    +  AS+    L+D+   Q++  D  E   W+ EK        Y +  +  
Sbjct: 1251 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLH 1310

Query: 926  EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDY------- 978
               LK H+A M++L++    +  + ++      +  P  +   KE +  L+         
Sbjct: 1311 SKWLK-HQAFMAELASNKEWLDKIEKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLEST 1368

Query: 979  -QEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSA-SRENLL 1036
             Q K+ R     K ++ T  +  + D W   +  +       Y K L        ++ +L
Sbjct: 1369 TQTKAQRLFDANKAELFTQ-SCADLDKWLHGLESQ--IQSDDYGKDLTSVNILLKKQQML 1425

Query: 1037 EEQGSIALRQ-EQIDNQTRITKEAGS----VSLRMKQVEELYHSLLELGEKRKGMLEKSC 1091
            E Q  +  ++ E++ +Q +   + G     V  +   V+  +  LLE   +RK  L  S 
Sbjct: 1426 ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASK 1485

Query: 1092 KKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDIN 1151
            +     R+  +   W+ E+    TS + G +L+ V++L KK    QK+++ ++ R+ DI 
Sbjct: 1486 EIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIF 1545

Query: 1152 KVAEDL--ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIK 1209
            + ++++  +S  L AE   A++Q+                                  + 
Sbjct: 1546 ERSQNIVTDSSSLSAE---AIRQR----------------------------------LA 1568

Query: 1210 ELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQ 1269
            +L + W  L +  E+R + L  AH  Q+++ DA E + W+ E+   + ++    D  S  
Sbjct: 1569 DLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV 1628

Query: 1270 ALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELNQAWSSLGKRA 1328
            ++ +KH+  E+ +    + V+ L +T+  L+  SHPES E +  + +++++ ++ L   A
Sbjct: 1629 SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPES-ERISMRQSKVDKLYAGLKDLA 1687

Query: 1329 DQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEI 1388
            ++R+ KL + H L +   +  DL  WI     +  S EL +D      L ER +E   + 
Sbjct: 1688 EERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDT 1747

Query: 1389 -DARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLEL 1447
             +              +L+  GH  +  I +  D L++  ADL +    R  +L    EL
Sbjct: 1748 GNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYEL 1807

Query: 1448 QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAF 1507
              F+ D ++    +  +   L  E+ G   ++VE L + H  F+  I     ++  LQ  
Sbjct: 1808 HKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQED 1866

Query: 1508 ADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAW 1566
            A +L AA    K D I  R NEVL+ W+ L      +R +L ++    +F   V ++  W
Sbjct: 1867 AARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLW 1926

Query: 1567 ISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGA 1626
            + + ++    E+ + P ++   +LL  +  HQ  +AE+ A  D     I++G SL+ R  
Sbjct: 1927 MEDVIRQI--EAQEKPRDVSSVELLMNN--HQGIKAEIDARNDSFTTCIELGKSLLARKH 1982

Query: 1627 CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALL 1686
             A  E  +K +L  L ++ + ++ K  ++ + L+   +   F+      + WL   E  L
Sbjct: 1983 YASEE--IKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2040

Query: 1687 ASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1722
            +S + G+ +  V  L+K+H+  E   +  ++R   L
Sbjct: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL 2076



 Score =  516 bits (1329), Expect = e-145
 Identities = 428/1900 (22%), Positives = 854/1900 (44%), Gaps = 139/1900 (7%)

Query: 372  DLTSWVTEMKALINADELASDVAGAEALLDRHQEH-----------KGEIDAHEDSFKS- 419
            DL  W+ +   ++N  + A+ + G +  L     +           KG ++    + +S 
Sbjct: 313  DLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSK 372

Query: 420  --ADESGQALLAAGHYASD--EVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
              A+     +   G   SD  +  E+L     ER   L    +R+++ EQ    + F R 
Sbjct: 373  MRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLA--RRFDRK 430

Query: 476  TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
                + W+S+ +  +  ++ G  L +VEA  KKHE  E  ++A EE++ A+   A +L  
Sbjct: 431  AAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEA 490

Query: 536  NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT 595
             N++ ++ +  R+D ++     L E    RR +L  +  LQ+ F++   +  W++E    
Sbjct: 491  ENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVL 550

Query: 596  ATDEAY-KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAK----DEVA 650
               + Y K    ++  +QKH   EA++     R+  +  + QK        K      + 
Sbjct: 551  VLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIR 610

Query: 651  ARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDL 710
             R+  +   +++L +    +  +L E+ +  +F   + + E W+ E E  L+SDDYGKDL
Sbjct: 611  DRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDL 670

Query: 711  TNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALK 770
            T+V  L  KH   E +++      +    +        HF +E I+++   +  ++  L+
Sbjct: 671  TSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLE 730

Query: 771  EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQ 830
            +    RK++L ++  L Q   D +D + W+ +   I +S++ G D    Q+L+KKH+ + 
Sbjct: 731  QLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVA 790

Query: 831  AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL 890
             EIA + P +  + ++ +A+ +E H  + DV+ +L  + ++++ +      R+Q L+D+L
Sbjct: 791  EEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 849

Query: 891  QAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALR 950
               + F++A+  E W+ EKE  + +    +  +  E +  + E+L  +++   S +  + 
Sbjct: 850  ALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 909

Query: 951  EQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVN 1010
            + A+       P++ E  K     L     +    V  KK  +L+ L+  N   + +E N
Sbjct: 910  QIARQLMHSGHPSEKEI-KAQQDKLNTRWSQFRELVDRKKDALLSALSIQN---YHLECN 965

Query: 1011 DRQGFVPAAYVKKLDPAQ----------SASRENLLEEQGSIALRQEQIDNQTRITK--- 1057
            + + ++     K ++  Q          +  R+    E+  +A+  +  D Q    K   
Sbjct: 966  ETKSWIREK-TKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLES 1024

Query: 1058 ----EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
                +A ++  R+ ++ +++  +    + R+  L ++ K     R+ ++ Q W++  + A
Sbjct: 1025 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTA 1084

Query: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
            + SE++   L + E L          L  +E+   +I+   ED +    M E V   Q  
Sbjct: 1085 IASEDMPNTLTEAEKL----------LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1134

Query: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
              Y  + +                          ++ L+  W  L ++ E R  LL  +H
Sbjct: 1135 AQYMFLRQ-------------------------RLQALDTGWNELHKMWENRQNLLSQSH 1169

Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
              Q+F RD  + + ++  +   L        L   +A  +K E F   + A  +K+N++ 
Sbjct: 1170 AYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVV 1229

Query: 1294 ETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMS 1353
            ET  RL+     +++ +QEK   ++       + A +   +L D+ DLQ+FL D ++L  
Sbjct: 1230 ETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSL 1289

Query: 1354 WINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYAS 1413
            WIN  + L + D    +     +   +HQ    E+ +        E+ G QL++      
Sbjct: 1290 WINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETE 1348

Query: 1414 PEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK 1473
              +K+KL  L +    LE     +   L    + +LF + C   + W+   E+ + ++D 
Sbjct: 1349 AVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDY 1408

Query: 1474 GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRW 1533
            G  L SV  L+KK +  +  + V++++I  LQ+ A  L   G  +  ++ S+R  V  ++
Sbjct: 1409 GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLTVQTKF 1467

Query: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
              L   + E++  L  S+ + QF+RDV++   W+ E++  A+   +    N+Q  +LL K
Sbjct: 1468 MELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH--NLQTVQLLIK 1525

Query: 1594 HQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSA 1653
              K+Q  + E+  +  RI  + +   +++   +   +E A++ RLA L   W  L++++ 
Sbjct: 1526 --KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE-AIRQRLADLKQLWGLLIEETE 1582

Query: 1654 EKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADIS 1713
            ++ ++L+EA++ Q +     + + W+SE E  + SE+  KD  S  ++LKKHQ+LE  + 
Sbjct: 1583 KRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVE 1642

Query: 1714 AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQ 1773
             + + +  L+  + +L+  S  ++ ++  ++  ++  +  +K +A  RR KL+E HRL Q
Sbjct: 1643 DYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQ 1702

Query: 1774 FFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAI-QGVLDTG 1832
              R++DD E WI E++++ GS + G+D   V  L+++ +    E A     I Q  +DT 
Sbjct: 1703 LNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR----EFARDTGNIGQERVDTV 1758

Query: 1833 KKLSDDNTIGKEEIQQRLAQFV----EHWKELKQLAAARGQRLEESLEYQQFVANVEEEE 1888
              L+D+           +A++     E W +L +L   R Q L  S E  +F  + +E  
Sbjct: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIF 1818

Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHH 1948
              I +K   +  E+ G     ++ L + H  FE D      +V  +  +   L       
Sbjct: 1819 GRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGD 1877

Query: 1949 EENISSKMKG--LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKT 2006
            + +   K +   L    S L+   ++R   +D    F  F+   D++  W+ +    ++ 
Sbjct: 1878 KADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLM-LWMEDVIRQIEA 1936

Query: 2007 DDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASL 2066
             +  RD+SSV+ L+   +   A + A + +       L   LLA KH  S+ I+ +   L
Sbjct: 1937 QEKPRDVSSVELLMNNHQGIKAEIDA-RNDSFTTCIELGKSLLARKHYASEEIKEKLLQL 1995

Query: 2067 MKRWSQLLANSAARKKKL-LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRC 2125
             ++  +++     R + L L  + H          F++ AS   +W    E  L+     
Sbjct: 1996 TEKRKEMIDKWEDRWEWLRLILEVH---------QFSRDASVAEAWLLGQEPYLSSREIG 2046

Query: 2126 NSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR 2185
             S++E++ L + H+AF  S ++    F+ L  L                 T+E LE    
Sbjct: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLT----------------TLELLE---- 2086

Query: 2186 NLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW 2225
                    R  + ++E++R+  + +   + ++ A +  QW
Sbjct: 2087 -------VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQW 2119



 Score =  509 bits (1310), Expect = e-143
 Identities = 414/1901 (21%), Positives = 839/1901 (44%), Gaps = 122/1901 (6%)

Query: 216  IQEQHPEEELIKTKQDEVNAAWQRLKGLALQ--RQGKLFGAA-----EVQRFNRDVDETI 268
            I   HP+E+ I T        + ++K LA++  R GK+   A      ++++     + +
Sbjct: 256  ISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL 315

Query: 269  SWIKEKEQLMASDDFGRDLASVQALLRKHE---------------GLERDLAALEDKVKA 313
             WI++   ++ +  F   L  VQ  L+                   LE  L  ++ K++A
Sbjct: 316  EWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRA 375

Query: 314  LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ--------R 365
               +    ++   +S         ++   WE++     ER   L +    Q        R
Sbjct: 376  NNQKVYMPREGKLIS---------DINKAWERLEKAEHERELALRNELIRQEKLEQLARR 426

Query: 366  FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
            F        +W++E + L++ D    D+   EA   +H+  + +I A+E+  ++     +
Sbjct: 427  FDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR 486

Query: 426  ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
             L A  ++    +  +   +      LLEL   RRQ+ E  + LQ  +++   + +WM +
Sbjct: 487  ELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDE 546

Query: 486  QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH-YAMEDV 544
             +  +L++D G  L  VE LL+KH   E  +  Q E++  ++  A K   +   Y   D 
Sbjct: 547  MKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDP 606

Query: 545  ATRRDALLSRR---NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY 601
               RD +         L + A  RRA+L +S  L +FF +  E + W+ EK K  + + Y
Sbjct: 607  QVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDY 666

Query: 602  -KDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
             KD +++   + KH+AFE E+S      +   K G+ +I   H+  +++  R+  +   W
Sbjct: 667  GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQW 726

Query: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
              L + + ++  +L EA+   QF  + +DI+ W+ ++   ++S D G D  + Q+L KKH
Sbjct: 727  ANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH 786

Query: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
              +  ++A ++  +D +  QA       H ++ +++ +   +  RY+ + E    RKQ L
Sbjct: 787  KDVAEEIANYRPTLDTLHEQASALPQE-HAESPDVRGRLSGIEERYKEVAELTRLRKQAL 845

Query: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
             D+L L ++F + +  E WI EKE    +    + L  ++ +  + ++L+ E+     R+
Sbjct: 846  QDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRV 905

Query: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
              V Q    ++  GH + +++KA+  +LN +W   +    +++  L  +L  Q Y  + N
Sbjct: 906  AVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECN 965

Query: 901  EAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
            E +SW+REK  ++ ST D G D     AL +K   +  DL A  + +  L+++A+    +
Sbjct: 966  ETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESE 1025

Query: 960  VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVP-- 1017
                  +  + ++  L +  +      T  K    +L  ++    +  +++D Q ++   
Sbjct: 1026 ----HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1081

Query: 1018 -AAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL------------ 1064
              A   +  P      E LL +  +I    +  +   +  ++ G +              
Sbjct: 1082 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141

Query: 1065 -RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
             R++ ++  ++ L ++ E R+ +L +S       R+  + + ++N +E  L   E+   L
Sbjct: 1142 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTL 1201

Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
            E  E   KK +DF   + ANE ++  + +    L S+G     + + + QE         
Sbjct: 1202 EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDG----NINSDRIQE--------- 1248

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
                                    +  +++R R  ++ A E    L    ++Q+F +D  
Sbjct: 1249 -----------------------KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ 1285

Query: 1244 ETKEWIEEKNQALNTDNYGHDLA-SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
            E   WI EK   L   +  +D A ++ +   KH+ F  +LA+  + ++ + +   +LI  
Sbjct: 1286 ELSLWINEK--MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE 1343

Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
             PE+   ++EK T L++ W  L      +  +L D++  + F     DL  W++G+   +
Sbjct: 1344 KPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQI 1403

Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422
             SD+  KD+T    LL++ Q    +++ R    +  +   Q L   G  ++ E+  K   
Sbjct: 1404 QSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKRLT 1462

Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482
            +  +  +L +   +R+  L    E+  F+RD E    W+  R     + D G +L +V+ 
Sbjct: 1463 VQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQL 1522

Query: 1483 LIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKAQMI 1541
            LIKK++   K I   + +I  +   +  ++        + I  R  ++   W  L  +  
Sbjct: 1523 LIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETE 1582

Query: 1542 EKRSKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQLSKLLSKHQKHQAF 1600
            ++  +L E+   QQ+  D  E EAW+SE+ L   S+E  KD  +      +S  +KHQ  
Sbjct: 1583 KRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSA-----VSMLKKHQIL 1637

Query: 1601 EAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLK 1660
            E  +   A+ +  +     +L+         + +  R + +   +  L   + E+  KL 
Sbjct: 1638 EQAVEDYAETVHQLSKTSRALVADSH--PESERISMRQSKVDKLYAGLKDLAEERRGKLD 1695

Query: 1661 EANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADI-SAHEDRL 1719
            E ++    N  + D + W++E E +  S + G+D   V  L ++ +    D  +  ++R+
Sbjct: 1696 ERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERV 1755

Query: 1720 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMD 1779
              +N  AD L+ S   D + + + +D +N  +  +  +  +R   L  S+ LH+F+ D  
Sbjct: 1756 DTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAK 1815

Query: 1780 DEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN 1839
            +    I++K   +  E+ GRD   V+ L++ H   E ++ A    ++ + +   +L    
Sbjct: 1816 EIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAY 1874

Query: 1840 TIGK-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLV 1898
               K ++IQ+R  + +E WK L     +R  RL ++ +  +F + V +   W+ + +  +
Sbjct: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI 1934

Query: 1899 ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG 1958
             +++    +++++ L+  H+  + +     D        G+ L+ + ++  E I  K+  
Sbjct: 1935 EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1994

Query: 1959 LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQT 2018
            L  K  ++      R   L       QF+  A V E+W+  +E  L + + G+ +  V+ 
Sbjct: 1995 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEK 2054

Query: 2019 LLTKQETFDAGLQAFQQ--EGIANITALKDQLLAAKHVQSK 2057
            L+ + E F+     + +    +  +T L  +LL  +  Q +
Sbjct: 2055 LIKRHEAFEKSAATWDERFSALERLTTL--ELLEVRRQQEE 2093



 Score =  498 bits (1283), Expect = e-140
 Identities = 431/1843 (23%), Positives = 824/1843 (44%), Gaps = 126/1843 (6%)

Query: 146  LQAQKLVQ-YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQT--DMAAHE 202
            ++ +K+++ Y     D+++WI     I+ + +    L  V+   + F  ++T        
Sbjct: 298  IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 357

Query: 203  ERVN-EVNQFAAKLIQEQHPEEELIKTKQ---DEVNAAWQRL------KGLALQ----RQ 248
            E+ N EV  F  +     + ++  +  +     ++N AW+RL      + LAL+    RQ
Sbjct: 358  EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 417

Query: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
             KL   A  +RF+R      +W+ E ++L++ D+FG DL +V+A  +KHE +E D+AA E
Sbjct: 418  EKLEQLA--RRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYE 475

Query: 309  DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLA 368
            ++V+A+ A A  L+  +     +I  +++ +I  WE +  L   R  RL  +  LQ+   
Sbjct: 476  ERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQ 535

Query: 369  DFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ--A 426
            +   +  W+ EMK L+ + +    + G E LL +H   + +I    +  +  + S Q  A
Sbjct: 536  EMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFA 595

Query: 427  LLAAGHYASDE--VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
                G+   D   +R+++  +      L +L   RR + E+   L  F+ +  + + W+ 
Sbjct: 596  TDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIR 655

Query: 485  KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
            ++E  L ++D G  L SV  LL KH  FE  +S +        +    +I   H+  E +
Sbjct: 656  EKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKI 715

Query: 545  ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-TATDEAYKD 603
              R   +  +   L + +  R+ +L ++  L QF  D+D++ +W+ + +K  ++ +   D
Sbjct: 716  RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD 775

Query: 604  PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
              + Q  V+KH+    E++  +  +D L +    L    H    +V  R++ +   +K++
Sbjct: 776  EYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASAL-PQEHAESPDVRGRLSGIEERYKEV 834

Query: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
             E T L+   L++     +     +  ELW+ E E  L +    + L +++ +Q +   L
Sbjct: 835  AELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESL 894

Query: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
            E ++     R+  +   ARQ   +GH   + IK +Q+ L  R+   +E +  +K  L  +
Sbjct: 895  EPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSA 954

Query: 784  LRLQQLFRDVEDEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
            L +Q    +  + ++WIREK  +  ST + G DL GV  L +K   ++ ++   E ++  
Sbjct: 955  LSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSD 1014

Query: 843  VTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEA 902
            + ++   +  E    A+ + ++L E++  WE +K     R   L ++ + QQ+  D ++ 
Sbjct: 1015 LQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDF 1074

Query: 903  ESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE----------- 951
            +SW+   +  + S D       AE LL +HE + +++  Y    Q +R+           
Sbjct: 1075 QSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1134

Query: 952  -QAQSCRQQVAPTDD---------ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTN 1001
             Q    RQ++   D          E  + L+   + YQ+   R+    +      LN+  
Sbjct: 1135 AQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQ-FLRDTKQAE----AFLNNQE 1189

Query: 1002 KDWWKVEVNDRQGFVPAAYVKKLD--PAQSASRE--NLLEEQGSIALRQEQIDNQTRITK 1057
                  E+        AA  K+ D      A+ E  N + E G   +    I N  RI +
Sbjct: 1190 YVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNI-NSDRIQE 1248

Query: 1058 EAGSVSLRMKQVEELYHSLL-ELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
            +  S+  R ++  E    LL  L + R        +KF+  ++  EL  WINEK   LT+
Sbjct: 1249 KVDSIDDRHRKNRETASELLMRLKDNR------DLQKFL--QDCQELSLWINEK--MLTA 1298

Query: 1117 EEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEV 1175
            +++  D    +     K   F  +L +N+  L  I K    L SE     E +AV ++++
Sbjct: 1299 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE---KPETEAVVKEKL 1355

Query: 1176 YGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEV 1235
             G                                 L++ W  L+   + ++Q L  A++ 
Sbjct: 1356 TG---------------------------------LHKMWEVLESTTQTKAQRLFDANKA 1382

Query: 1236 QRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGET 1295
            + F +   +  +W+      + +D+YG DL SV  L +K +  E  +     ++  L   
Sbjct: 1383 ELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1442

Query: 1296 AERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWI 1355
            A+ L Q   +S +++  K   +   +  L +  ++RK  L  S ++ +F  D  D + W+
Sbjct: 1443 AQALSQ-EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501

Query: 1356 NGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE 1415
                 L +S +   ++   + L++++Q  + EI           +  Q ++      S E
Sbjct: 1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1561

Query: 1416 -IKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKG 1474
             I+Q+L  L Q    L +   +R   L++    Q ++ D  +AE WM+ +E ++ +E+K 
Sbjct: 1562 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1621

Query: 1475 DSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWR 1534
                S  +++KKH+  ++A+    E +  L   +  L+A  H     IS R+++V   + 
Sbjct: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1681

Query: 1535 RLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASD----ESYKDPTNIQLSKL 1590
             LK    E+R KL E   L Q +R+VD++E WI+E+   A      + Y+  T +Q    
Sbjct: 1682 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQ---- 1737

Query: 1591 LSKHQKHQAFEAEL-HANADRIRGVIDMGNSLIERGACAGSEDAVKARLA-ALADQWQFL 1648
                ++ + F  +  +   +R+  V  + + LI  G    S+ A  A     L + W  L
Sbjct: 1738 ----ERFREFARDTGNIGQERVDTVNHLADELINSG---HSDAATIAEWKDGLNEAWADL 1790

Query: 1649 VQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLL 1708
            ++    ++Q L  + +   F    K+    + +    L  E+ G+D  +V  L + H   
Sbjct: 1791 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRMHTTF 1849

Query: 1709 EADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDT-INGRFQKIKSMAASRRAKLNE 1767
            E DI A   +++ L   A  L  + A D +    KR+  +   ++ +     SRR +L +
Sbjct: 1850 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1909

Query: 1768 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQG 1827
            +    +FF  + D   W+++    + +++  RD++ V+ L   H+ ++AE+ A   +   
Sbjct: 1910 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1969

Query: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
             ++ GK L        EEI+++L Q  E  KE+      R + L   LE  QF  +    
Sbjct: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029

Query: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDR 1930
            EAW+  +   ++S + G ++  ++ L+K+HEAFE       +R
Sbjct: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDER 2072



 Score =  414 bits (1063), Expect = e-115
 Identities = 355/1628 (21%), Positives = 714/1628 (43%), Gaps = 104/1628 (6%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIASDENYK 73
            I  R+  V+  +    EL   RRQ+LE +   Q   ++   +  W+ E K+ + S +  K
Sbjct: 499  ITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGK 558

Query: 74   DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS----ETIRTRLMELHR 129
                ++  LQKH   EA++   +  +  ++ +     ++G        + IR R+  +  
Sbjct: 559  HLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEF 618

Query: 130  QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
             ++ L +   E+  +L ++++L ++  E  +   WI +KE I++S++ G+DL  V  L  
Sbjct: 619  CYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLS 678

Query: 190  KFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
            K   F+ +M+       +  +    +I E+H   E I+ +   +   W  L+ L+  R+ 
Sbjct: 679  KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 738

Query: 250  KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
            +L  A+ + +F  D D+  +W+ +  ++++S D G D  S Q+L++KH+ +  ++A    
Sbjct: 739  RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798

Query: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
             +  L  +A  L Q H   +  ++ +   +   ++++  L   R   L D+  L +  ++
Sbjct: 799  TLDTLHEQASALPQEH-AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 857

Query: 370  FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
                  W+ E +  +N  ++   +   E +  R +  + E++         ++  + L+ 
Sbjct: 858  ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 917

Query: 430  AGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM-SKQEA 488
            +GH +  E++ +   L+   +   EL + ++      + +Q ++ +  +  +W+  K + 
Sbjct: 918  SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 977

Query: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
                +DLG+ L  V AL +K    E+ L A E K++ L + A KL   +    + + +R 
Sbjct: 978  IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1037

Query: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
              +      +      R A L ++  LQQF RD D+ +SW++   +T T  A +D  N  
Sbjct: 1038 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS---RTQTAIASEDMPNTL 1094

Query: 609  GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE--------VAARMNEVISLW 660
             + +K       +   ++ ID  E+  QK+ D+               +  R+  + + W
Sbjct: 1095 TEAEKLLTQHENI---KNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW 1151

Query: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
             +L +  E +   L +++  QQF R+ +  E +L   E  LA  +    L   +   KK 
Sbjct: 1152 NELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQ 1211

Query: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
                  + A++++I+ +    R+    G+ +++ I++K +++  R+   +E       +L
Sbjct: 1212 EDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRL 1271

Query: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
             D+  LQ+  +D ++   WI EK  + A      +   + +   KHQA  AE+A ++  +
Sbjct: 1272 KDNRDLQKFLQDCQELSLWINEK-MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWL 1330

Query: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
              + ++G  ++ E       VK KL  L++ WE L++    + Q L D+ +A+ +     
Sbjct: 1331 DKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCA 1390

Query: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
            + + W+   E  + S DYGKD  S   LLKK + L + +      I+ L+ QAQ+  Q+ 
Sbjct: 1391 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG 1450

Query: 961  APTDDETGKELVLALYDYQEKSPREVTMKKGDILTL--LNSTNKD------WWKVEVNDR 1012
              TD+   K L +     +   P  +  +K ++L    ++  N+D      W    V +R
Sbjct: 1451 KSTDEVDSKRLTVQTKFMELLEP--LNERKHNLLASKEIHQFNRDVEDEILW----VGER 1504

Query: 1013 QGFVPAA-YVKKLDPAQSASRENLL---EEQGSIALRQEQIDNQTRITKEAGSVSL---- 1064
                 +  +   L   Q   ++N     E QG      +  +    I  ++ S+S     
Sbjct: 1505 MPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR 1564

Query: 1065 -RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
             R+  +++L+  L+E  EKR   LE++ +    + +A E + W++E+E  + SEE   D 
Sbjct: 1565 QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDE 1624

Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
            +    + KK    ++ ++     +  ++K +  L ++     E  +++Q +V        
Sbjct: 1625 QSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKV-------- 1676

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
                                        ++ +  L+ LAEER   L   H + + +R+ D
Sbjct: 1677 ----------------------------DKLYAGLKDLAEERRGKLDERHRLFQLNREVD 1708

Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALG-DKVNSLGETAERLIQS 1302
            + ++WI E+     +   G D   V  LQ +   F RD   +G ++V+++   A+ LI S
Sbjct: 1709 DLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINS 1768

Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
                A  + E    LN+AW+ L +  D R   L  S++L +F  D +++   I   +   
Sbjct: 1769 GHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQD-KHKK 1827

Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA--HGHYASPEIKQKL 1420
              +EL +D    E L   H     +I A     +  ++   +L A   G  A    K++ 
Sbjct: 1828 LPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKREN 1887

Query: 1421 DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
            ++L+  ++ L+    +R  ++D   + + F         WM      +  ++K   + SV
Sbjct: 1888 EVLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VRDLMLWMEDVIRQIEAQEKPRDVSSV 1946

Query: 1481 EALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDI-------SSRRNEVLDRW 1533
            E L+  H+     I+ + +           L+A  HYA  +I       + +R E++D+W
Sbjct: 1947 ELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKW 2006

Query: 1534 RRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSK 1593
                    ++   L     + QFSRD    EAW+  +    S        + ++ KL+  
Sbjct: 2007 E-------DRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVD-EVEKLI-- 2056

Query: 1594 HQKHQAFE 1601
             ++H+AFE
Sbjct: 2057 -KRHEAFE 2063



 Score =  362 bits (930), Expect = 2e-99
 Identities = 322/1435 (22%), Positives = 620/1435 (43%), Gaps = 129/1435 (8%)

Query: 13   EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI--ASDE 70
            ++I+ ++ ++  R+ +F+EL   ++  L  +   Q +  +  E + WI+EK ++  ++ +
Sbjct: 924  KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983

Query: 71   NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
               D   +    +K    E ++ A    +  L +    + SE    ++ I +RL E+   
Sbjct: 984  LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043

Query: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
            WE +   ++ +   L +A KL Q+LR+ +D   W++  +  + SE++   L   E L  +
Sbjct: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQ 1103

Query: 191  FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL-IKTKQDEVNAAWQRLKGLALQRQG 249
             E  + ++  +EE   ++      + Q Q   + + ++ +   ++  W  L  +   RQ 
Sbjct: 1104 HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQN 1163

Query: 250  KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALED 309
             L  +   Q+F RD  +  +++  +E ++A  +    L   +A ++K E     + A E+
Sbjct: 1164 LLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEE 1223

Query: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
            K+ A+     RL     +++ +IQ K + +     + R  A+E   RL D+  LQ+FL D
Sbjct: 1224 KINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD 1283

Query: 370  FRDLTSWVTEMKALINADELASDVA-GAEALLDRHQEHKGEIDAHEDSFKSADESGQALL 428
             ++L+ W+ E   ++ A +++ D A    +   +HQ    E+ ++++     ++ G  L+
Sbjct: 1284 CQELSLWINEK--MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLI 1341

Query: 429  AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEA 488
            +        V+EKLT L +    L    + + Q+       +LF +    +D W+   E+
Sbjct: 1342 SEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLES 1401

Query: 489  FLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRR 548
             + ++D G  L SV  LLKK +  E  +  ++++I  L   A  L Q    + ++V ++R
Sbjct: 1402 QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK-STDEVDSKR 1460

Query: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-KDPSNL 607
              + ++   L E    R+  L  S  + QF RD ++   WV E+M  AT   +  +   +
Sbjct: 1461 LTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTV 1520

Query: 608  QGKVQKHQAFEAELSANQSRIDALEKAGQKLI-DVNHYAKDEVAARMNEVISLWKKLLEA 666
            Q  ++K+Q  + E+  +Q RID + +  Q ++ D +  + + +  R+ ++  LW  L+E 
Sbjct: 1521 QLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEE 1580

Query: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
            TE +  +L EA++ QQ+  +  + E W+ E E ++ S++  KD  +  ++ KKH +LE  
Sbjct: 1581 TEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQA 1640

Query: 727  VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
            V  + + +  ++  +R      H ++E I  +Q  +   Y  LK+    R+ KL +  RL
Sbjct: 1641 VEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRL 1700

Query: 787  QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG-HEPRIKAVTQ 845
             QL R+V+D E WI E+E +A S   G+D   V  L ++ +    +     + R+  V  
Sbjct: 1701 FQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNH 1760

Query: 846  KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905
              + ++  GH  A  +      LN+ W  L      R Q L  S +  +++ DA E    
Sbjct: 1761 LADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGR 1820

Query: 906  MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965
            +++K   +   + G+D+++ E L + H     D+ A G+ ++ L+E A   R Q A   D
Sbjct: 1821 IQDKHKKLPE-ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA--ARLQAAYAGD 1877

Query: 966  ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA------ 1019
            +          D  +K   EV      +L    S       V+  D+  F          
Sbjct: 1878 KA---------DDIQKRENEVLEAWKSLLDACESRRVRL--VDTGDKFRFFSMVRDLMLW 1926

Query: 1020 ---YVKKLD----PAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQV--E 1070
                +++++    P   +S E L+     I    +  ++      E G   L  K    E
Sbjct: 1927 MEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE 1986

Query: 1071 ELYHSLLELGEKRKGMLEKSCKKF----------MLFREANELQQWINEKEAALTSEEVG 1120
            E+   LL+L EKRK M++K   ++             R+A+  + W+  +E  L+S E+G
Sbjct: 1987 EIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIG 2046

Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDIN----------------------------- 1151
              +++VE L K+ + F+K     + R   +                              
Sbjct: 2047 QSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPS 2106

Query: 1152 -KVAEDLESE--------------GLMAEE-----VQAVQQQEVYGMMPRDETDSKTASP 1191
             KV+E+ ES+              GL AE+      + V   E+        T SK +SP
Sbjct: 2107 TKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSP 2166

Query: 1192 WKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEE 1251
              S            +        R+ +  + +    L   HE +  ++ A  ++ W   
Sbjct: 2167 IPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKAS-SRSW--- 2222

Query: 1252 KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQ 1311
                       H++  V  +  +  GF +D            +TA   I  H E    L+
Sbjct: 2223 -----------HNVYCV--INNQEMGFYKD-----------AKTAASGIPYHSEVPVSLK 2258

Query: 1312 EKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDE 1366
            E   E+   +    K+    K +L D ++      D  ++ +WI  I   +SSD+
Sbjct: 2259 EAVCEVALDYK---KKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAISSDK 2310



 Score =  297 bits (760), Expect = 1e-79
 Identities = 181/542 (33%), Positives = 293/542 (54%), Gaps = 5/542 (0%)

Query: 11   TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEK-LQIASD 69
            +AE I++R   +   +    E +  R ++LE+++R Q +  DA E E W+ E+ L + S+
Sbjct: 1559 SAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE 1618

Query: 70   ENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
            E  KD  +    L+KHQ  E  V+  +  + +L +T   ++++ H  SE I  R  ++ +
Sbjct: 1619 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDK 1678

Query: 130  QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQK 189
             +  L +   E+  KL +  +L Q  RE +D+  WI ++E +  S ELGQD EHV +LQ+
Sbjct: 1679 LYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE 1738

Query: 190  KFEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQ 248
            +F EF  D     +ERV+ VN  A +LI   H +   I   +D +N AW  L  L   R 
Sbjct: 1739 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1798

Query: 249  GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALE 308
              L  + E+ +F  D  E    I++K + +  ++ GRD  +V+ L R H   E D+ AL 
Sbjct: 1799 QILAASYELHKFYHDAKEIFGRIQDKHKKLP-EELGRDQNTVETLQRMHTTFEHDIQALG 1857

Query: 309  DKVKALCAEADRLQQSHPLS-ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFL 367
             +V+ L  +A RLQ ++    A  IQ +  E++  W+ +      R  RL D+    RF 
Sbjct: 1858 TQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFF 1917

Query: 368  ADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQAL 427
            +  RDL  W+ ++   I A E   DV+  E L++ HQ  K EIDA  DSF +  E G++L
Sbjct: 1918 SMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL 1977

Query: 428  LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487
            LA  HYAS+E++EKL  L+E+R  +++ WE R +     +++  F RD    + W+  QE
Sbjct: 1978 LARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQE 2037

Query: 488  AFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT-KLIQNNHYAMEDVAT 546
             +L + ++G S+D VE L+K+HE FEKS +  +E+ +AL+   T +L++      E+   
Sbjct: 2038 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERK 2097

Query: 547  RR 548
            RR
Sbjct: 2098 RR 2099



 Score =  251 bits (641), Expect = 6e-66
 Identities = 212/911 (23%), Positives = 417/911 (45%), Gaps = 74/911 (8%)

Query: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE-KLQIAS 68
            ET   ++E+   +   +   +  +  + Q+L D+ + + F +   +L+KW+   + QI S
Sbjct: 1346 ETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQS 1405

Query: 69   DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASE------TIRT 122
            D+  KD T++   L+K Q  E +++     I +L      +  EG    E      T++T
Sbjct: 1406 DDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT 1465

Query: 123  RLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLE 182
            + ME       LLE + E+   LL ++++ Q+ R+ ED + W+ ++  + TS + G +L+
Sbjct: 1466 KFME-------LLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQ 1518

Query: 183  HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP-EEELIKTKQDEVNAAWQRLK 241
             V++L KK +  Q ++  H+ R++++ + +  ++ +      E I+ +  ++   W  L 
Sbjct: 1519 TVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLI 1578

Query: 242  GLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLE 301
                +R  +L  A   Q++  D  E  +W+ E+E  M S++  +D  S  ++L+KH+ LE
Sbjct: 1579 EETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILE 1638

Query: 302  RDLAALEDKVKALCAEADRL-QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS 360
            + +    + V  L   +  L   SHP  + +I +++ ++   +  ++ LA ER  +L++ 
Sbjct: 1639 QAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQSKVDKLYAGLKDLAEERRGKLDER 1697

Query: 361  YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEI-DAHEDSFKS 419
            +RL +   +  DL  W+ E + +  + EL  D      L +R +E   +  +  ++   +
Sbjct: 1698 HRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDT 1757

Query: 420  ADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQV 479
             +     L+ +GH  +  + E    L+E  A LLEL + R Q      +L  FY D +++
Sbjct: 1758 VNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1817

Query: 480  DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHY 539
               +  +    L E+LG   ++VE L + H  FE  + A   ++  L E A +L     Y
Sbjct: 1818 FGRIQDKHK-KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARL--QAAY 1874

Query: 540  A---MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-T 595
            A    +D+  R + +L    +L +    RR +L D+    +FF    +L  W+ + ++  
Sbjct: 1875 AGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI 1934

Query: 596  ATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNE 655
               E  +D S+++  +  HQ  +AE+ A         + G+ L+   HYA +E+  ++ +
Sbjct: 1935 EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQ 1994

Query: 656  VISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQN 715
            +    K++++  E +   LR   +  QF+R+    E WL   E +L+S + G+ +  V+ 
Sbjct: 1995 LTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEK 2054

Query: 716  LQKKHALLEADVAAHQDRIDGI-------TIQARQFQDAGHFD------------AENIK 756
            L K+H   E   A   +R   +        ++ R+ Q+                 +E  +
Sbjct: 2055 LIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAE 2114

Query: 757  KKQEALVARYEALKE---PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRG 813
             +Q+   ++ E + +   P      ++A+++   ++     ++ T  +E  PI + T+  
Sbjct: 2115 SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSD- 2173

Query: 814  KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQK-- 871
                      K   AL A+ A   P   A TQ+  +   EG             LN+K  
Sbjct: 2174 ---------RKAKTALPAQSAATLP---ARTQETPSAQMEGF------------LNRKHE 2209

Query: 872  WEALKAKASQR 882
            WEA   KAS R
Sbjct: 2210 WEAHNKKASSR 2220



 Score = 98.2 bits (243), Expect = 9e-20
 Identities = 128/611 (20%), Positives = 244/611 (39%), Gaps = 86/611 (14%)

Query: 1751 FQKIKSMAASRRA------KLNESHRLHQFFRDM-DDEESWIKEKKLLVGSEDYGRDLTG 1803
            F K+K++A   +          E+ ++ + +  +  D   WI++  +++ +  +   L G
Sbjct: 277  FSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG 336

Query: 1804 VQ----------------------NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTI 1841
            VQ                      NL      +++++ A+   +    + GK +SD N  
Sbjct: 337  VQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE-GKLISDIN-- 393

Query: 1842 GKEEIQQRLAQFVEHWKELKQLAAARGQRL-EESLEY--QQFVANVEEEEAWINEKMTLV 1898
               +  +RL +  EH +EL    A R + + +E LE   ++F       E W++E   LV
Sbjct: 394  ---KAWERLEK-AEHEREL----ALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLV 445

Query: 1899 ASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKG 1958
            + +++G  L A++   KKHEA ETD   +++RV  V    ++L  +N H  + I+++   
Sbjct: 446  SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 505

Query: 1959 LNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQT 2018
            +      L +    R+ +L+ N    +   +   +  W+ E +  + + DYG+ L  V+ 
Sbjct: 506  VIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVED 565

Query: 2019 LLTKQETFDA--GLQAFQQEGI-ANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLA 2075
            LL K    +A  G+QA +  G+ A+           K    + I  R A +   + +L  
Sbjct: 566  LLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ 625

Query: 2076 NSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALR 2135
             +A R+ +L E+    R++   F   A++      W    E+ L+       L  +  L 
Sbjct: 626  LAAERRARLEES----RRLWKFFWEMAEE----EGWIREKEKILSSDDYGKDLTSVMRLL 677

Query: 2136 EAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERE 2195
              H AF   +S     F Q  +    + +     +      +  + E W NL+++   R+
Sbjct: 678  SKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRK 737

Query: 2196 LELQKEQRRQEENDKLRQEFAQHANAFHQWIQE----------------TRTYLLDGSCM 2239
              L        E   L  +F   A+    W+ +                T++ +     +
Sbjct: 738  KRL--------EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDV 789

Query: 2240 VEESG-------TLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHST 2292
             EE         TL  Q  A  ++H E   +R +L  IE+    + E   L  K     T
Sbjct: 790  AEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL-RKQALQDT 848

Query: 2293 VGLAQQWDQLD 2303
            + L + + + D
Sbjct: 849  LALYKMFSEAD 859



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 61/296 (20%), Positives = 119/296 (40%), Gaps = 18/296 (6%)

Query: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
            A Q  G+  +   +D  ++  H   K+I     +    +S++ A  A   K++ +   + 
Sbjct: 241  AEQHLGLTKLLDPED--ISVDHPDEKSIITYVVTYYHYFSKMKA-LAVEGKRIGKVLDNA 297

Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQ-A 2150
             + E +   +   AS    W E     L +    NSL  ++   +A + +R+     +  
Sbjct: 298  IETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFT 357

Query: 2151 DFNQLAELDRQIKSFRVASNPYTWFTMEA-----LEETWRNLQKIIKERELELQKEQRRQ 2205
            +   L  L   I+S   A+N   +   E      + + W  L+K   EREL L+ E  RQ
Sbjct: 358  EKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQ 417

Query: 2206 EENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ----EIR 2261
            E+ ++L + F + A     W+ E +  +       +  G     +EA  +KH+    +I 
Sbjct: 418  EKLEQLARRFDRKAAMRETWLSENQRLVSQ-----DNFGFDLPAVEAATKKHEAIETDIA 472

Query: 2262 AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQI 2317
            A   +++ +  +   +E     D K        + + W+ L +L    +  LE  +
Sbjct: 473  AYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNL 528


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score =  568 bits (1463), Expect = e-161
 Identities = 450/1737 (25%), Positives = 806/1737 (46%), Gaps = 151/1737 (8%)

Query: 610  KVQKHQAFEAELSANQSRIDALEKA------GQKLIDVNHYAKDEVAARMNEVISLWKKL 663
            K Q+    E  L   QSR+ A  +       G+ + D+N   +    A     ++L  +L
Sbjct: 355  KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNEL 414

Query: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
            +   +L+ +  R       F+R     E WL E +  +A D++G DL  V+  +KKH  +
Sbjct: 415  IRQEKLEQLARR-------FDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAI 467

Query: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
            E D AA+++R+  +   A++ +   + D + I  +++ ++  +  L+E + +R+Q+L  +
Sbjct: 468  ETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETT 527

Query: 784  LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
            L LQ+LF+D+     W+ E +    S   GK L+ V++LL+KH+ ++A+IA    ++KA+
Sbjct: 528  LALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAI 587

Query: 844  TQKGNAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
            T       E   +   D   ++ ++  L Q +E L   A+ R+  LE S +  ++F + +
Sbjct: 588  TAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMD 647

Query: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQS--CRQ 958
            EAESW++EKE I  S DYGKD  S   L +KH+A   +L    + ++ + ++A     R+
Sbjct: 648  EAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARK 707

Query: 959  QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA 1018
            Q      E   + V A +D Q K       K      L ++ N   ++ + +D + ++  
Sbjct: 708  QFGHPQIEARIKEVSAQWD-QLKDLAAFCKKN-----LQDAENFFQFQGDADDLKAWLQD 761

Query: 1019 AY--------------VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL 1064
            A+               + L        E L E +G +   ++Q        +++  V+ 
Sbjct: 762  AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTH 821

Query: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
            R++ + ELY  ++   + R+  L+++   + +F E +  + W+ EKE  L   E+   LE
Sbjct: 822  RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLE 881

Query: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDL-ESEGLMAEEVQAVQQQEVYGMMPRDE 1183
             +EV+Q +FD   +++K   +++  +N  A  L ES    + EV+  Q            
Sbjct: 882  DLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDH---------- 931

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
                                       LN RW++ Q L  ER + + SA  V  +  D +
Sbjct: 932  ---------------------------LNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964

Query: 1244 ETKEWIEEKNQAL-NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
            ET +WI +K + + +T + G DLA + A+QRK  G ERD+AA+  +V++L   +++L+ S
Sbjct: 965  ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDS 1024

Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
            HPE  ED+ ++   L + W  L +    ++  LG+   LQ FL D  D  +W++  +  V
Sbjct: 1025 HPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAV 1084

Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQK 1419
            +S+++ + +  AE LL++H   + EID    ++Q  ++ G++++       PE   + Q+
Sbjct: 1085 ASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQR 1142

Query: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
            L+ LD     L + W  R   L QCL  Q F +D +QAE  ++ +E  L   +  DSL++
Sbjct: 1143 LEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEA 1202

Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
             EA I+K EDF  ++    +K+ +     ++L+A G+     I  +   + DR R+   +
Sbjct: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262

Query: 1540 MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
              E    L ++  LQ F ++  E+  WI++KL T+ D SY +  N+      +K  KHQA
Sbjct: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLH-----NKWLKHQA 1317

Query: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
            F AEL ++   +  +   G  L++      +   V  +L AL   W  L   + EK+Q L
Sbjct: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTA--LVSQKLEALHRLWDELQATTKEKTQHL 1375

Query: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719
              A           D + W+S +E  L S+D GKDL SVN +L K + +E  ++  ++ L
Sbjct: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEEL 1435

Query: 1720 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMD 1779
             +L +Q  S+            D   +I  RF  +      R+ +L  S    Q  RD++
Sbjct: 1436 GELFAQVPSMGEEGG-------DADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLE 1488

Query: 1780 DEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN 1839
            DE  W++E+  L  S DYG +L  VQ   KK++ L+ E+  H P ++ VL  G++L +  
Sbjct: 1489 DETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA 1548

Query: 1840 TIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVA 1899
             I  +++++RL      W  L++ AA R QRL ++ E QQ+  + +E EAWI E+   V 
Sbjct: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI 1608

Query: 1900 SEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL 1959
            S++          +LK+H   +     +   +  + +  Q L+   +   E I      +
Sbjct: 1609 SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQV 1668

Query: 1960 NGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTL 2019
            +   + L+  A +RK KL+      Q   + D +E WI EKE    + + G+D   V  L
Sbjct: 1669 DKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLL 1728

Query: 2020 LTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2079
              K   F     A  QE + N+ A  ++L+ A H ++  I      L + W+ LL     
Sbjct: 1729 RDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDT 1788

Query: 2080 RKKKL------------------LEAQSHFRKVEDLFL------TFAKKASAFN------ 2109
            R + L                  L  + H    ED+ L      +F +  +AF       
Sbjct: 1789 RMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLL 1848

Query: 2110 ----SWFENAEEDLTDPVRCNSLEEIK-ALREAHDAFRSSLSSAQADFNQLAELDRQIKS 2164
                  F++    L         E I+   +E   A+++ L +      QL +   + + 
Sbjct: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908

Query: 2165 FRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQ 2224
            F +A +  +W            ++ II++ E +   E+ R   + +L  ++ Q  NA   
Sbjct: 1909 FSMARDLLSW------------MESIIRQIETQ---ERPRDVSSVELLMKYHQGINA--- 1950

Query: 2225 WIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL 2281
               ETR+     +C+      L+ Q +A++   ++++ + S+ K++ +   A  E L
Sbjct: 1951 -EIETRSKNF-SACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005



 Score =  519 bits (1337), Expect = e-146
 Identities = 376/1418 (26%), Positives = 673/1418 (47%), Gaps = 93/1418 (6%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72
            I+ R ++V  ++ + K+L+   ++ L+D+  F  FQ DA++L+ W+Q+  ++ S E+   
Sbjct: 714  IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773

Query: 73   -KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
             +  T   GK  KH+ F  E++ + G +  L++       E    S  +  RL  L   +
Sbjct: 774  DEGATRALGK--KHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELY 830

Query: 132  ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
            + ++ +   +  +L +A  L     E +    W+ +KE  +   E+   LE +EV+Q +F
Sbjct: 831  QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890

Query: 192  EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
            +    +M     +++ VN  A  L++  HP    +K  QD +N  WQ  + L  +R+  +
Sbjct: 891  DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950

Query: 252  FGAAEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQALLRKHEGLERDLAALEDK 310
              A  V  +  D +ET  WI +K +++ S  D GRDLA + A+ RK  GLERD+AA++ +
Sbjct: 951  DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010

Query: 311  VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370
            V AL  E+ +L  SHP     I  +++ L   W+ ++     +   L +  +LQ FL D 
Sbjct: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070

Query: 371  RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
             D  +W++  +  + ++++   +  AE LL +H   K EID H+DS++   ESG+ ++  
Sbjct: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130

Query: 431  GHYASDE----VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
                +D     + ++L  L     AL  +WE R     QC+  Q F +D +Q +  +S Q
Sbjct: 1131 ---QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ 1187

Query: 487  EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
            E  L + +  DSL++ EA ++K EDF  S+    +K+ +  +   KL+   +   + +  
Sbjct: 1188 EYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKE 1247

Query: 547  RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606
            +   +  R    +E+A      L D+  LQ F ++  EL  W+N+K+ T+ D +Y +  N
Sbjct: 1248 KVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307

Query: 607  LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
            L  K  KHQAF AEL++++  ++ ++  G++L+D        V+ ++  +  LW +L   
Sbjct: 1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQAT 1367

Query: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
            T+ K   L  A       +   D+  W+  +E  L SDD GKDLT+V  +  K   +E  
Sbjct: 1368 TKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ 1427

Query: 727  VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
            V   ++ +  +  Q     + G     +I+K       R+  L EP+  RK++L  S   
Sbjct: 1428 VNVRKEELGELFAQVPSMGEEGGDADLSIEK-------RFLDLLEPLGRRKKQLESSRAK 1480

Query: 787  QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK 846
             Q+ RD+EDE  W+ E+ P+A S + G +L  VQ  +KK+Q LQ EI GH PR++ V Q+
Sbjct: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540

Query: 847  GNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
            G  +VE      +D++ +L  L   W+ L+  A+ R Q L D+ +AQQY+ DA+EAE+W+
Sbjct: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600

Query: 907  REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-------QQ 959
             E+E  V S +  KDE+ A  +LK+H      +  YG +I+ L  +AQ          +Q
Sbjct: 1601 GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQ 1660

Query: 960  VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
            +     +  K     L D  E+  R+          L N  +    K E +D + ++   
Sbjct: 1661 IIRLQGQVDKHYA-GLKDVAEERKRK----------LENMYHLFQLKRETDDLEQWISEK 1709

Query: 1020 YVKKLDP--AQSASRENLLEEQ------GSIALRQEQIDNQTRITK--------EAGSVS 1063
             +    P   Q      LL ++       + A+ QE++DN     +        EA +++
Sbjct: 1710 ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIA 1769

Query: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
                 + E++  LLEL + R  +L  S      F    E+   I+EK   L  E+VG D 
Sbjct: 1770 EWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELP-EDVGLDA 1828

Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
               E   +    F+++L     +++    VA  L++     E+ +A+Q +E         
Sbjct: 1829 STAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT-AYAGEKAEAIQNKE--------- 1878

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQRFHRDA 1242
                                     +E++  W++L    A  R+QL+ +A +  RF   A
Sbjct: 1879 -------------------------QEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMA 1912

Query: 1243 DETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
             +   W+E   + + T     D++SV+ L + H+G   ++       ++  E  E L+Q 
Sbjct: 1913 RDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQR 1972

Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
              +++E+++EK  ++      + ++ + R  +L    ++ +F  D     +W+      +
Sbjct: 1973 QHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYL 2032

Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
            +S +    V   E L++RH+       + A  F A E+
Sbjct: 2033 ASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070



 Score =  474 bits (1220), Expect = e-133
 Identities = 363/1523 (23%), Positives = 705/1523 (46%), Gaps = 93/1523 (6%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73
            IQ+R   +   +     ++  R+ +LE S R   F  + +E E WI+EK QI S  +Y K
Sbjct: 608  IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGK 667

Query: 74   DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
            D T++    +KH+AFE E++     + ++ +  + M++   F    I  R+ E+  QW+ 
Sbjct: 668  DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQ 727

Query: 134  LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
            L +        L  A+   Q+  + +D+  W+ D   +++ E++GQD      L KK ++
Sbjct: 728  LKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKD 787

Query: 194  FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
            F  ++      +  + Q A    +E     ++    Q  +   +Q++   A  RQ +L  
Sbjct: 788  FLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ-ALRELYQQVVAQADLRQQRLQE 846

Query: 254  AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
            A ++     + D    W+ EKE+ +A  +    L  ++ +  + + L++++  L  ++  
Sbjct: 847  ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDG 906

Query: 314  LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
            +   A+ L +S    + +++  ++ L T W+  +TL +ER   ++ + R+  +  D  + 
Sbjct: 907  VNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966

Query: 374  TSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
            + W+T+  K + +  +L  D+AG  A+  +    + ++ A +    + +   Q L+ +  
Sbjct: 967  SKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026

Query: 433  YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492
               +++ ++   L E    L +  + +     +   LQ F +D +    W+S  +  + +
Sbjct: 1027 EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS 1086

Query: 493  EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN---HYAMEDVATRRD 549
            ED+ +SL   E LL++H   +  +   ++    + E   K+IQ      Y +  +  R +
Sbjct: 1087 EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--LGQRLE 1144

Query: 550  ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQG 609
             L +  NAL      R   LA     Q+F +D+ + ++ ++ +  T      + P +L+ 
Sbjct: 1145 GLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAH--LEPPDSLEA 1202

Query: 610  K---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
                ++K + F   +  N+ ++ +   +G KL+   +   D++  ++  +    +K  E 
Sbjct: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262

Query: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEA 725
             +   + LR+  + Q F +N +++ LW+ +    L S D   D   N+ N   KH    A
Sbjct: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVSYDEARNLHNKWLKHQAFVA 1320

Query: 726  DVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLR 785
            ++A+H+  ++ I  + +Q  D        + +K EAL   ++ L+     + Q L+ +  
Sbjct: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380

Query: 786  LQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
                 +   D   WI   E    S + GKDL  V  +L K + ++ ++   +  +  +  
Sbjct: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440

Query: 846  KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905
            +  +M EEG  A   ++ +  +L +          +R++ LE S    Q   D  +   W
Sbjct: 1441 QVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQLESSRAKLQISRDLEDETLW 1493

Query: 906  MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965
            + E+ P+  S DYG +  + +  +KK++ L +++  +   ++ + ++ Q    Q+    +
Sbjct: 1494 VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ----QLVEAAE 1549

Query: 966  ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025
               ++L   L   Q    R      G +  L ++     + ++ ++ + ++    +  + 
Sbjct: 1550 IDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI- 1608

Query: 1026 PAQSASRENLLEEQGSIAL------RQEQIDNQTRITKEAGSVS--------------LR 1065
                 S E   +E+G+I +      +Q  +++  R  K+  S +              +R
Sbjct: 1609 -----SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIR 1663

Query: 1066 MK-QVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
            ++ QV++ Y  L ++ E+RK  LE     F L RE ++L+QWI+EKE   +S E+G D +
Sbjct: 1664 LQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFD 1723

Query: 1125 QVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
             V +L+ KF DF ++  A  + R+ ++N   E L   G                      
Sbjct: 1724 HVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG---------------------H 1762

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
            +++ T + WK                 LNE W  L +L + R QLL +++++ R+     
Sbjct: 1763 SEAATIAEWKDG---------------LNEMWADLLELIDTRMQLLAASYDLHRYFYTGA 1807

Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
            E    I+EK++ L  D  G D ++ ++  R H  FER+L  LG +V    + A RL  ++
Sbjct: 1808 EILGLIDEKHRELPED-VGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAY 1866

Query: 1304 P-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
              E AE +Q K  E++ AW +L      R+ +L D+ D  RF S  RDL+SW+  I   +
Sbjct: 1867 AGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI 1926

Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422
             + E  +DV+  E L++ HQ    EI+ R+  F A  + G+ LL   H AS EI++KL  
Sbjct: 1927 ETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQ 1986

Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482
            +   R ++ + W  R   L   LE+  F RD   AE W+ A+E +L + D G ++DSVE 
Sbjct: 1987 VMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046

Query: 1483 LIKKHEDFDKAINVQEEKIAALQ 1505
            LIK+HE F+K+     E+ AAL+
Sbjct: 2047 LIKRHEAFEKSTASWAERFAALE 2069



 Score =  463 bits (1191), Expect = e-129
 Identities = 383/1744 (21%), Positives = 783/1744 (44%), Gaps = 103/1744 (5%)

Query: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD 69
            E+ E+ + RR+  L           +R++KLE   R   F R A   E W+ E  ++ + 
Sbjct: 397  ESLEEAEYRRELALRN-------ELIRQEKLEQLARR--FDRKAAMRETWLSENQRLVAQ 447

Query: 70   ENYK-DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
            +N+  D   ++   +KH+A E +  A    +  L++    +  E +   + I  R   + 
Sbjct: 448  DNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNIL 507

Query: 129  RQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQ 188
            R W  L E ++ +  +L     L +  ++    +DW+++ +A + S E G+ L  VE L 
Sbjct: 508  RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLL 567

Query: 189  KKFEEFQTDMAAHEERVNEVNQFAAKLIQE---QHPEEELIKTKQDEVNAAWQRLKGLAL 245
            +K +  + D+A   ++V  +     K  +    Q  + ++I+ +   +   ++ L  +A 
Sbjct: 568  QKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAA 627

Query: 246  QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
             R+ +L  +  + +F  ++DE  SWIKEKEQ+ +S D+G+DL SV  L RKH+  E +L 
Sbjct: 628  GRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELR 687

Query: 306  ALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQR 365
             L+  ++ +  EA  +         QI+ + +E+   W+Q++ LAA     L D+    +
Sbjct: 688  GLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQ 747

Query: 366  FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
            F  D  DL +W+ +   L++ +++  D     AL  +H++   E++      +  ++  Q
Sbjct: 748  FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807

Query: 426  ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
                     S +V  +L  L E    ++   +LR+Q+ ++ +DL   + +T+  + WM +
Sbjct: 808  G-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866

Query: 486  QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVA 545
            +E +L   ++ D+L+ +E +  + +  ++ +     +I  ++  A  L+++ H    +V 
Sbjct: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926

Query: 546  TRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKD 603
              +D L +R  A       RR  +  +  +  +  D +E   W+ +K K   +T +  +D
Sbjct: 927  QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986

Query: 604  PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
             + +    +K    E +++A Q+R+DALE+  Q+L+D +   K+++  R   +  LW+ L
Sbjct: 987  LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046

Query: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
             ++ + +   L E +Q Q F ++++D + WL   +  +AS+D  + L   + L ++HA +
Sbjct: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106

Query: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAEN--IKKKQEALVARYEALKEPMVARKQKLA 781
            + ++  HQD    +  ++ +    G  D E   + ++ E L   + AL     +R   LA
Sbjct: 1107 KDEIDGHQDSYQRVK-ESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165

Query: 782  DSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841
              L  Q+  +D +  E  +  +E   A       L   +  ++K +     +  +  ++ 
Sbjct: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225

Query: 842  AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901
            +    GN +V EG+  ++ +K K+  +  +      KA +    L D+L+ Q +  +  E
Sbjct: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285

Query: 902  AESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYG---SSIQALREQAQSCR 957
               W+ +K  ++ S D   DE  +      KH+A +++L+++     +I A  +Q    +
Sbjct: 1286 LTLWINDK--LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEK 1343

Query: 958  QQVAPTDDETGKELVLALYDYQEKSPREVTM----KKGDILTLLNSTNKDWWKVEVNDRQ 1013
             Q      +   E +  L+D  + + +E T      +   L L    + + W   + D+ 
Sbjct: 1344 PQFTALVSQK-LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ- 1401

Query: 1014 GFVPAAYVKKLDPAQSASREN-----LLEEQGSIALRQEQID----NQTRITKEAGSVSL 1064
                   ++  DP +  +  N     L   +  + +R+E++         + +E G   L
Sbjct: 1402 -------LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454

Query: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
                +E+ +  LLE   +RK  LE S  K  + R+  +   W+ E+     S + G +L+
Sbjct: 1455 ---SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQ 1511

Query: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDET 1184
             V++  KK    Q ++  +  R++D+ +  + L    + A E+     +E  G       
Sbjct: 1512 TVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQL----VEAAEIDCQDLEERLG------- 1560

Query: 1185 DSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADE 1244
                                      L   W  L++ A  R Q L  A+E Q+++ DADE
Sbjct: 1561 -------------------------HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595

Query: 1245 TKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS-H 1303
             + WI E+   + +D    D      + ++H   +R +   G  +  L   A+ L+ + H
Sbjct: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGH 1655

Query: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
            PE  E +     ++++ ++ L   A++RK KL + + L +   +  DL  WI+    + S
Sbjct: 1656 PE-GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVAS 1714

Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDA----RAGTFQAFEQFGQQLLAHGHYASPEIKQK 1419
            S E+ +D      L ++ ++   E  A    R     AF    ++L+  GH  +  I + 
Sbjct: 1715 SPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI---ERLIDAGHSEAATIAEW 1771

Query: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
             D L++  ADL +    R  +L    +L  +     +    +  +   L  ED G    +
Sbjct: 1772 KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL-PEDVGLDAST 1830

Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKA 1538
             E+  + H  F++ +++   ++   Q  A +L  A    K + I ++  EV   W+ L  
Sbjct: 1831 AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLD 1890

Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
                +R++L ++    +F     ++ +W+   ++    E+ + P ++   +LL K+  HQ
Sbjct: 1891 ACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI--ETQERPRDVSSVELLMKY--HQ 1946

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
               AE+   +      +++G SL++R   A  E  ++ +L  +  + + + +K   + ++
Sbjct: 1947 GINAEIETRSKNFSACLELGESLLQRQHQASEE--IREKLQQVMSRRKEMNEKWEARWER 2004

Query: 1659 LKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1718
            L+   +   F+      + WL   E  LAS D+G  + SV  L+K+H+  E   ++  +R
Sbjct: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064

Query: 1719 LKDL 1722
               L
Sbjct: 2065 FAAL 2068



 Score =  454 bits (1169), Expect = e-127
 Identities = 388/1785 (21%), Positives = 792/1785 (44%), Gaps = 132/1785 (7%)

Query: 146  LQAQKLVQ-YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQT--DMAAHE 202
            ++ +K+++ Y     D++ WI     ++ S +    L  V+   + F  ++T       +
Sbjct: 298  IETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQ 357

Query: 203  ERVN-EVNQFAAKLIQEQHPEEELIKTKQD-----EVNAAWQRL------KGLALQ---- 246
            E+ N EV  F  +         + + T  D     ++N AW+ L      + LAL+    
Sbjct: 358  EKGNLEVLLFTIQ--SRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415

Query: 247  RQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAA 306
            RQ KL   A  +RF+R      +W+ E ++L+A D+FG DLA+V+A  +KHE +E D AA
Sbjct: 416  RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAA 473

Query: 307  LEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRF 366
             E++V+AL   A  L++ +     +I  +++ ++  W  ++ L   R  RL  +  LQ+ 
Sbjct: 474  YEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKL 533

Query: 367  LADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQA 426
              D      W+ E+KA + + E    +   E LL +H+  + +I    D  K+   +   
Sbjct: 534  FQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLK 593

Query: 427  LLAAGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM 483
                  Y   +   ++++++ L +    L  +   R+ Q EQ   L  F+ + ++ ++W+
Sbjct: 594  FTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWI 653

Query: 484  SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
             ++E    + D G  L SV  L +KH+ FE  L   +  +  + + A  ++    +    
Sbjct: 654  KEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ 713

Query: 544  VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-K 602
            +  R   + ++ + L + A   +  L D+ +  QF  D+D+LK+W+ +  +  + E   +
Sbjct: 714  IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773

Query: 603  DPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKK 662
            D    +   +KH+ F  EL  ++  ++ LE+  Q   +    + D V  R+  +  L+++
Sbjct: 774  DEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELYQQ 832

Query: 663  LLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHAL 722
            ++   +L+  +L+EA          +  ELW+ E E  LA  +    L +++ +Q +  +
Sbjct: 833  VVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDI 892

Query: 723  LEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
            L+ ++     +IDG+ + A    ++GH  +  +K+ Q+ L  R++A +  +  R++ +  
Sbjct: 893  LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952

Query: 783  SLRLQQLFRDVEDEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841
            +LR+     D E+   WI +K  +  ST + G+DL G+  + +K   L+ ++A  + R+ 
Sbjct: 953  ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVD 1012

Query: 842  AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901
            A+ ++   +++      ED+  +   L + W+ L+     +   L +  Q Q +  D ++
Sbjct: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDD 1072

Query: 902  AESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVA 961
             ++W+   +  V S D  +    AE LL++H  +  ++  +  S Q ++E  +   Q   
Sbjct: 1073 FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ--G 1130

Query: 962  PTDDE---TGKELV------LALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDR 1012
             TD E    G+ L        AL    E     +    G          KD  + E    
Sbjct: 1131 QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG-----FQEFQKDAKQAEAILS 1185

Query: 1013 QGFVPAAYVKKLDPAQSASR--ENLLEEQGSIALRQEQI----DNQTRITKEAGSVSLRM 1066
                  A+++  D  ++A        +  GS+   ++++    D+  ++  E    S ++
Sbjct: 1186 NQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKI 1245

Query: 1067 KQ----VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGAD 1122
            K+    +E+ +    E  ++   +L  + +     +   EL  WIN+K   LTS++V  D
Sbjct: 1246 KEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDVSYD 1303

Query: 1123 LEQVEVLQK--KFDDFQKDLKANESRLKDINK---------------VAEDLESEGLMAE 1165
             E   +  K  K   F  +L ++E  L++I+                V++ LE+   + +
Sbjct: 1304 -EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWD 1362

Query: 1166 EVQAVQQQEVYGMMPRDETDSKTAS-------------------PWKSARLMVHTVATFN 1206
            E+QA  +++   +     +D +  +                   P K    +   +A   
Sbjct: 1363 ELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLK 1422

Query: 1207 SIK--------ELNERWRSLQQLAEE---------------------RSQLLGSAHEVQR 1237
             ++        EL E +  +  + EE                     R + L S+    +
Sbjct: 1423 RVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQ 1482

Query: 1238 FHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297
              RD ++   W+EE+     + +YG +L +VQ   +K++  + ++     +V  + +  +
Sbjct: 1483 ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ 1542

Query: 1298 RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWING 1357
            +L+++     +DL+E+   L  +W  L + A  R  +L D+++ Q++  D  +  +WI  
Sbjct: 1543 QLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGE 1602

Query: 1358 IRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK 1417
                V SDE+ KD  GA  +L+RH   +  ++      +      Q LL+ GH    +I 
Sbjct: 1603 QELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQII 1662

Query: 1418 QKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477
            +    +D+  A L+    +R+  L+    L    R+ +  E W++ +E   ++ + G   
Sbjct: 1663 RLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDF 1722

Query: 1478 DSVEALIKKHEDFDKAIN-VQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL 1536
            D V  L  K  DF +    + +E++  + AF ++LI AGH     I+  ++ + + W  L
Sbjct: 1723 DHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADL 1782

Query: 1537 KAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQK 1596
               +  +   L  S  L ++     EI   I EK +   ++   D +  +     S H+ 
Sbjct: 1783 LELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAE-----SFHRV 1837

Query: 1597 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEK 1655
            H AFE ELH    +++   D+   L  + A AG + +A++ +   ++  WQ L+   A +
Sbjct: 1838 HTAFERELHLLGVQVQQFQDVATRL--QTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895

Query: 1656 SQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAH 1715
              +L +   +  F +  +D   W+  +   + +++  +D++SV  L+K HQ + A+I   
Sbjct: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955

Query: 1716 EDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFF 1775
                       +SL+      + ++++K   +  R +++     +R  +L     + QF 
Sbjct: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015

Query: 1776 RDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
            RD    E+W+  ++  + S D+G  +  V+ L K+H+  E   A+
Sbjct: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060



 Score =  420 bits (1080), Expect = e-117
 Identities = 408/1856 (21%), Positives = 796/1856 (42%), Gaps = 139/1856 (7%)

Query: 372  DLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEIDAHEDSFKSA 420
            DL +W+ +   ++N+ + A+ + G +  L               + KG ++    + +S 
Sbjct: 313  DLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSR 372

Query: 421  DESGQALLAAGH---YASDEVR--EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
              +    +   H     SD  R  E L      R   L    +R+++ EQ    + F R 
Sbjct: 373  MRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLA--RRFDRK 430

Query: 476  TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
                + W+S+ +  +  ++ G  L +VEA  KKHE  E   +A EE++ AL++ A +L +
Sbjct: 431  AAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490

Query: 536  NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE-KMK 594
             N++  + +  R+D +L   + L E    RR +L  +  LQ+ F+D      W++E K  
Sbjct: 491  ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550

Query: 595  TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE---VAA 651
              + E  K    ++  +QKH+  EA+++    ++ A+  A  K  +   Y   +   +  
Sbjct: 551  LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610

Query: 652  RMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLT 711
            R++ +   +++L      +  +L ++ +  +F   +++ E W+ E E   +S DYGKDLT
Sbjct: 611  RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670

Query: 712  NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771
            +V  LQ+KH   E ++      ++ I  +A        F    I+ + + + A+++ LK+
Sbjct: 671  SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730

Query: 772  PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831
                 K+ L D+    Q   D +D + W+++   + +  + G+D    + L KKH+    
Sbjct: 731  LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790

Query: 832  EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891
            E+      ++ + Q+     EE    + DV  +L  L + ++ + A+A  R+Q L+++L 
Sbjct: 791  ELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849

Query: 892  AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
                F + +  E WM EKE  +   +     +  E +  + + L  ++    + I  +  
Sbjct: 850  LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909

Query: 952  QAQSCRQQVAPTDDETGK-----------------------ELVLALYDYQ---EKSPRE 985
             A S  +   P   E  +                       +  L +++Y    E++ + 
Sbjct: 910  AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969

Query: 986  VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKL-----DPAQSASRENLLEEQG 1040
            +T K     T +  + KD  +    D  G +  A  +KL     D A   +R + LE + 
Sbjct: 970  ITDK-----TKVVESTKDLGR----DLAGII--AIQRKLSGLERDVAAIQARVDALERES 1018

Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREA 1100
                 Q+ +D+     ++ G    R K +EEL+  L +  + ++ +L +  +     ++ 
Sbjct: 1019 -----QQLMDSHPEQKEDIGQ---RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070

Query: 1101 NELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESE 1160
            ++ Q W++  + A+ SE++   L + E L ++    + ++  ++   + + +  E +   
Sbjct: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV--- 1127

Query: 1161 GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ 1220
                  +Q     E   +  R                          ++ L+  W +L +
Sbjct: 1128 ------IQGQTDPEYLLLGQR--------------------------LEGLDTGWNALGR 1155

Query: 1221 LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFER 1280
            + E RS  L      Q F +DA + +  +  +   L        L + +A  RK E F  
Sbjct: 1156 MWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLG 1215

Query: 1281 DLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD 1340
             +    DKV S  ++  +L+      ++ ++EK   +        ++A +    L D+ +
Sbjct: 1216 SMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE 1275

Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
            LQ FL + ++L  WIN  + L S D    +         +HQ    E+ +  G  +  + 
Sbjct: 1276 LQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334

Query: 1401 FGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENW 1460
             G+QL+      +  + QKL+ L +   +L+    ++   L       L  +       W
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394

Query: 1461 MAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG 1520
            ++A E  L ++D G  L SV  ++ K +  +  +NV++E++  L A    +   G  A  
Sbjct: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454

Query: 1521 DISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYK 1580
             I  R  ++L+   R K Q+   R+KL       Q SRD+++   W+ E+L  A    Y 
Sbjct: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKL-------QISRDLEDETLWVEERLPLAQSADYG 1507

Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
              TN+Q  +L  K  K+Q  + E+  +  R+  V+  G  L+E       +  ++ RL  
Sbjct: 1508 --TNLQTVQLFMK--KNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD--LEERLGH 1561

Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNN 1700
            L   W  L + +A + Q+L++AN+ Q +     + + W+ E E  + S++  KD      
Sbjct: 1562 LQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIV 1621

Query: 1701 LLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAAS 1760
            +LK+H   +  +  +   +K L S+A  L+++   +  Q+   +  ++  +  +K +A  
Sbjct: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEE 1681

Query: 1761 RRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
            R+ KL   + L Q  R+ DD E WI EK+L+  S + G+D   V  LR K +    E  A
Sbjct: 1682 RKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGA 1741

Query: 1821 -HEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQ 1879
              +  +  V    ++L D        I +      E W +L +L   R Q L  S +  +
Sbjct: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801

Query: 1880 FVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT---VHKDRVNDVCT 1936
            +     E    I+EK   +  ED G   +  +   + H AFE +     V   +  DV T
Sbjct: 1802 YFYTGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860

Query: 1937 NGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESW 1996
              Q          E I +K + ++     L  A A R+ +L + +   +F   A  + SW
Sbjct: 1861 RLQTAYA--GEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSW 1918

Query: 1997 IGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQS 2056
            +      ++T +  RD+SSV+ L+   +  +A ++  + +  +    L + LL  +H  S
Sbjct: 1919 MESIIRQIETQERPRDVSSVELLMKYHQGINAEIET-RSKNFSACLELGESLLQRQHQAS 1977

Query: 2057 KAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAE 2116
            + I  +   +M R  ++     AR ++L       R + ++   F++ AS   +W    E
Sbjct: 1978 EEIREKLQQVMSRRKEMNEKWEARWERL-------RMLLEV-CQFSRDASVAEAWLIAQE 2029

Query: 2117 EDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE-LDRQIKSFRVASNP 2171
              L      ++++ ++ L + H+AF  S +S    F  L +    ++K  ++A  P
Sbjct: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085



 Score =  280 bits (715), Expect = 2e-74
 Identities = 224/998 (22%), Positives = 448/998 (44%), Gaps = 60/998 (6%)

Query: 4    SGVKVLETAED-----IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEK 58
            SG KV++   D     + +R + +   ++    +   R   L     FQ FQ+DA++ E 
Sbjct: 1123 SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEA 1182

Query: 59   WIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS 117
             +  ++  +A  E        +  ++K + F   ++ N   ++   ++GN +++EG+  S
Sbjct: 1183 ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242

Query: 118  ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEEL 177
            + I+ ++  +  +     EK +E  + L    +L  +L+ C+++  WINDK  ++TS+++
Sbjct: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDV 1300

Query: 178  GQD-LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236
              D   ++     K + F  ++A+HE  +  ++    +L+ E+     L+  K + ++  
Sbjct: 1301 SYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRL 1360

Query: 237  WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
            W  L+    ++   L  A       +   +   WI   E  + SDD G+DL SV  +L K
Sbjct: 1361 WDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAK 1420

Query: 297  HEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHAR 356
             + +E  +   ++++  L A+   + +    +   I+ +  +L+            R  +
Sbjct: 1421 LKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQ 1473

Query: 357  LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416
            L  S    +   D  D T WV E   L  + +  +++   +  + ++Q  + EI  H   
Sbjct: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533

Query: 417  FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476
             +   + GQ L+ A      ++ E+L  L      L E    R Q+     + Q +Y D 
Sbjct: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593

Query: 477  EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN 536
            ++ + W+ +QE +++++++    +    +LK+H   ++++      I  L   A  L+  
Sbjct: 1594 DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA 1653

Query: 537  NHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA 596
             H   E +   +  +      L + A  R+ +L + +HL Q  R++D+L+ W++EK   A
Sbjct: 1654 GHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVA 1713

Query: 597  TD-EAYKDPSNLQGKVQKHQAFEAELSA-NQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
            +  E  +D  ++     K + F  E  A  Q R+D +    ++LID  H     +A   +
Sbjct: 1714 SSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKD 1773

Query: 655  EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714
             +  +W  LLE  + +   L  +    ++     +I L L + +     +D G D +  +
Sbjct: 1774 GLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI-LGLIDEKHRELPEDVGLDASTAE 1832

Query: 715  NLQKKHALLEADVAAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVAR 765
            +  + H   E ++         + +Q +QFQD         AG   AE I+ K++ + A 
Sbjct: 1833 SFHRVHTAFERELHL-------LGVQVQQFQDVATRLQTAYAGE-KAEAIQNKEQEVSAA 1884

Query: 766  YEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKK 825
            ++AL +    R+ +L D+    + F    D  +W+        +  R +D+  V+ L+K 
Sbjct: 1885 WQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKY 1944

Query: 826  HQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH-------ELNQKWEALKAK 878
            HQ + AEI        A  + G ++++  H A+E+++ KL        E+N+KWEA    
Sbjct: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA---- 2000

Query: 879  ASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD 938
               R + L   L+  Q+  DA+ AE+W+  +EP + S D+G   DS E L+K+HEA    
Sbjct: 2001 ---RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKS 2057

Query: 939  LSAYGSSIQAL----------REQAQSCRQQVAPTDDE 966
             +++     AL          R+ A+   ++  P ++E
Sbjct: 2058 TASWAERFAALEKPTTLELKERQIAERPAEETGPQEEE 2095



 Score =  216 bits (551), Expect = 2e-55
 Identities = 195/864 (22%), Positives = 366/864 (42%), Gaps = 71/864 (8%)

Query: 1544 RSKLGESQTLQQFSRDVDEI----EAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
            R++L   + L+Q +R  D      E W+SE  +  + +++       L+ + +  +KH+A
Sbjct: 411  RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF----GYDLAAVEAAKKKHEA 466

Query: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
             E +  A  +R+R + D+   L +       +  + AR   +   W +L +    + Q+L
Sbjct: 467  IETDTAAYEERVRALEDLAQELEKENY--HDQKRITARKDNILRLWSYLQELLQSRRQRL 524

Query: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719
            +     Q     +     W+ E++A L S ++GK L  V +LL+KH+L+EADI+   D++
Sbjct: 525  ETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKV 584

Query: 1720 KDLNSQADSLMTSSAF---DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFR 1776
            K + +          +   D   ++D+   +   F+++ +MAA R+A+L +S RL +FF 
Sbjct: 585  KAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFW 644

Query: 1777 DMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLS 1836
            +MD+ ESWIKEK+ +  S DYG+DLT V  L++KHK  E EL   +  ++ +      + 
Sbjct: 645  EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704

Query: 1837 DDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT 1896
                 G  +I+ R+ +    W +LK LAA   + L+++  + QF  + ++ +AW+ +   
Sbjct: 705  ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHR 764

Query: 1897 LVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKM 1956
            L++ ED G    A + L KKH+ F  +    +  +  +    Q    +      +++ ++
Sbjct: 765  LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRL 823

Query: 1957 KGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSV 2016
            + L      +   A  R+ +L E         + D  E W+GEKE  L   +    L  +
Sbjct: 824  QALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDL 883

Query: 2017 QTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLAN 2076
            + +  + +  D  ++    + I  +    + L+ + H +S+ ++     L  RW      
Sbjct: 884  EVVQHRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTL 942

Query: 2077 SAARKKKL---LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2133
             + R++ +   L   ++    E+       K     S      +DL        L  I A
Sbjct: 943  VSERREAVDSALRVHNYCVDCEETSKWITDKTKVVES-----TKDLG-----RDLAGIIA 992

Query: 2134 LREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
            ++         +++ QA  + L    +Q+               + LEE W+ LQ+    
Sbjct: 993  IQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ---- 1048

Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEAT 2253
                LQ ++    E  +L Q F Q  + F  W+  T+  +     M E     E  L+  
Sbjct: 1049 ---SLQGQEDLLGEVSQL-QAFLQDLDDFQAWLSITQKAVASED-MPESLPEAEQLLQQH 1103

Query: 2254 KRKHQEIRAMRSQLKKIEDLGAAM------EEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307
                 EI   +   +++++ G  +       E L+L  +       GL   W+ L ++  
Sbjct: 1104 AGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLE-----GLDTGWNALGRMWE 1158

Query: 2308 RMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKD---KSGRLNHQEFKSCLRSLGYDL 2364
               H L Q                   + F+ F KD       L++QE+          L
Sbjct: 1159 SRSHTLAQ------------------CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200

Query: 2365 PMVEEGEPDPEFEAILDTVDPNRD 2388
               E G    +FE  L +++ NRD
Sbjct: 1201 EAAEAG--IRKFEDFLGSMENNRD 1222



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 15/247 (6%)

Query: 2078 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2137
            A   K++ +   H  + E +   ++  AS   +W E     L      NSL  ++   +A
Sbjct: 284  AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343

Query: 2138 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASN-----PYTWFTMEALEETWRNLQKII 2191
               +R+     +  +   L  L   I+S   A+N     P+    +  +   W +L++  
Sbjct: 344  FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403

Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2251
              REL L+ E  RQE+ ++L + F + A     W+ E +  +       +  G   + +E
Sbjct: 404  YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQ-----DNFGYDLAAVE 458

Query: 2252 ATKRKHQEIR----AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307
            A K+KH+ I     A   +++ +EDL   +E+    D K        + + W  L +L  
Sbjct: 459  AAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQ 518

Query: 2308 RMQHNLE 2314
              +  LE
Sbjct: 519  SRRQRLE 525



 Score = 45.1 bits (105), Expect = 9e-04
 Identities = 75/396 (18%), Positives = 152/396 (38%), Gaps = 38/396 (9%)

Query: 1995 SWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA--FQQEGIANITALKDQLLAAK 2052
            +WI +    L +  +   L+ VQ  L    T+    +   FQ++G  N+  L   + +  
Sbjct: 316  TWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG--NLEVLLFTIQSRM 373

Query: 2053 HVQSKAIEARH-----ASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASA 2107
               ++ +   H     + + + W  L      R+  L        K+E L   F +KA+ 
Sbjct: 374  RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAM 433

Query: 2108 FNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRV 2167
              +W    +  +        L  ++A ++ H+A  +  ++ +     L +L ++++    
Sbjct: 434  RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493

Query: 2168 ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQ 2227
                      + +   W  LQ++++ R   L+     Q    KL Q+     +    W+ 
Sbjct: 494  HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQ----KLFQDMLHSID----WMD 545

Query: 2228 ETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA-MRSQLKKIEDLGAAM------EEA 2280
            E + +LL       E G    ++E   +KH+ + A +  Q  K++ + AA       +  
Sbjct: 546  EIKAHLLSA-----EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600

Query: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA---LKEFSMMF 2337
               D +  +     L Q +++L  +    +  LEQ  +        +EA   +KE   ++
Sbjct: 601  QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660

Query: 2338 KHFD--KDKSGRL----NHQEFKSCLRSLGYDLPMV 2367
               D  KD +  L     H+ F+  LR L   L  +
Sbjct: 661  SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQI 696


>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score =  568 bits (1463), Expect = e-161
 Identities = 450/1737 (25%), Positives = 806/1737 (46%), Gaps = 151/1737 (8%)

Query: 610  KVQKHQAFEAELSANQSRIDALEKA------GQKLIDVNHYAKDEVAARMNEVISLWKKL 663
            K Q+    E  L   QSR+ A  +       G+ + D+N   +    A     ++L  +L
Sbjct: 355  KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNEL 414

Query: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
            +   +L+ +  R       F+R     E WL E +  +A D++G DL  V+  +KKH  +
Sbjct: 415  IRQEKLEQLARR-------FDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAI 467

Query: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
            E D AA+++R+  +   A++ +   + D + I  +++ ++  +  L+E + +R+Q+L  +
Sbjct: 468  ETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETT 527

Query: 784  LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
            L LQ+LF+D+     W+ E +    S   GK L+ V++LL+KH+ ++A+IA    ++KA+
Sbjct: 528  LALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAI 587

Query: 844  TQKGNAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
            T       E   +   D   ++ ++  L Q +E L   A+ R+  LE S +  ++F + +
Sbjct: 588  TAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMD 647

Query: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQS--CRQ 958
            EAESW++EKE I  S DYGKD  S   L +KH+A   +L    + ++ + ++A     R+
Sbjct: 648  EAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARK 707

Query: 959  QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA 1018
            Q      E   + V A +D Q K       K      L ++ N   ++ + +D + ++  
Sbjct: 708  QFGHPQIEARIKEVSAQWD-QLKDLAAFCKKN-----LQDAENFFQFQGDADDLKAWLQD 761

Query: 1019 AY--------------VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL 1064
            A+               + L        E L E +G +   ++Q        +++  V+ 
Sbjct: 762  AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTH 821

Query: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
            R++ + ELY  ++   + R+  L+++   + +F E +  + W+ EKE  L   E+   LE
Sbjct: 822  RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLE 881

Query: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDL-ESEGLMAEEVQAVQQQEVYGMMPRDE 1183
             +EV+Q +FD   +++K   +++  +N  A  L ES    + EV+  Q            
Sbjct: 882  DLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDH---------- 931

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
                                       LN RW++ Q L  ER + + SA  V  +  D +
Sbjct: 932  ---------------------------LNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964

Query: 1244 ETKEWIEEKNQAL-NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
            ET +WI +K + + +T + G DLA + A+QRK  G ERD+AA+  +V++L   +++L+ S
Sbjct: 965  ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDS 1024

Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
            HPE  ED+ ++   L + W  L +    ++  LG+   LQ FL D  D  +W++  +  V
Sbjct: 1025 HPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAV 1084

Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQK 1419
            +S+++ + +  AE LL++H   + EID    ++Q  ++ G++++       PE   + Q+
Sbjct: 1085 ASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQR 1142

Query: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
            L+ LD     L + W  R   L QCL  Q F +D +QAE  ++ +E  L   +  DSL++
Sbjct: 1143 LEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEA 1202

Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
             EA I+K EDF  ++    +K+ +     ++L+A G+     I  +   + DR R+   +
Sbjct: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262

Query: 1540 MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
              E    L ++  LQ F ++  E+  WI++KL T+ D SY +  N+      +K  KHQA
Sbjct: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLH-----NKWLKHQA 1317

Query: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
            F AEL ++   +  +   G  L++      +   V  +L AL   W  L   + EK+Q L
Sbjct: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTA--LVSQKLEALHRLWDELQATTKEKTQHL 1375

Query: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719
              A           D + W+S +E  L S+D GKDL SVN +L K + +E  ++  ++ L
Sbjct: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEEL 1435

Query: 1720 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMD 1779
             +L +Q  S+            D   +I  RF  +      R+ +L  S    Q  RD++
Sbjct: 1436 GELFAQVPSMGEEGG-------DADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLE 1488

Query: 1780 DEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN 1839
            DE  W++E+  L  S DYG +L  VQ   KK++ L+ E+  H P ++ VL  G++L +  
Sbjct: 1489 DETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA 1548

Query: 1840 TIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVA 1899
             I  +++++RL      W  L++ AA R QRL ++ E QQ+  + +E EAWI E+   V 
Sbjct: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI 1608

Query: 1900 SEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL 1959
            S++          +LK+H   +     +   +  + +  Q L+   +   E I      +
Sbjct: 1609 SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQV 1668

Query: 1960 NGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTL 2019
            +   + L+  A +RK KL+      Q   + D +E WI EKE    + + G+D   V  L
Sbjct: 1669 DKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLL 1728

Query: 2020 LTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2079
              K   F     A  QE + N+ A  ++L+ A H ++  I      L + W+ LL     
Sbjct: 1729 RDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDT 1788

Query: 2080 RKKKL------------------LEAQSHFRKVEDLFL------TFAKKASAFN------ 2109
            R + L                  L  + H    ED+ L      +F +  +AF       
Sbjct: 1789 RMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLL 1848

Query: 2110 ----SWFENAEEDLTDPVRCNSLEEIK-ALREAHDAFRSSLSSAQADFNQLAELDRQIKS 2164
                  F++    L         E I+   +E   A+++ L +      QL +   + + 
Sbjct: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908

Query: 2165 FRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQ 2224
            F +A +  +W            ++ II++ E +   E+ R   + +L  ++ Q  NA   
Sbjct: 1909 FSMARDLLSW------------MESIIRQIETQ---ERPRDVSSVELLMKYHQGINA--- 1950

Query: 2225 WIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL 2281
               ETR+     +C+      L+ Q +A++   ++++ + S+ K++ +   A  E L
Sbjct: 1951 -EIETRSKNF-SACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005



 Score =  519 bits (1337), Expect = e-146
 Identities = 376/1418 (26%), Positives = 673/1418 (47%), Gaps = 93/1418 (6%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72
            I+ R ++V  ++ + K+L+   ++ L+D+  F  FQ DA++L+ W+Q+  ++ S E+   
Sbjct: 714  IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773

Query: 73   -KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
             +  T   GK  KH+ F  E++ + G +  L++       E    S  +  RL  L   +
Sbjct: 774  DEGATRALGK--KHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELY 830

Query: 132  ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
            + ++ +   +  +L +A  L     E +    W+ +KE  +   E+   LE +EV+Q +F
Sbjct: 831  QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890

Query: 192  EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
            +    +M     +++ VN  A  L++  HP    +K  QD +N  WQ  + L  +R+  +
Sbjct: 891  DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950

Query: 252  FGAAEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQALLRKHEGLERDLAALEDK 310
              A  V  +  D +ET  WI +K +++ S  D GRDLA + A+ RK  GLERD+AA++ +
Sbjct: 951  DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010

Query: 311  VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370
            V AL  E+ +L  SHP     I  +++ L   W+ ++     +   L +  +LQ FL D 
Sbjct: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070

Query: 371  RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
             D  +W++  +  + ++++   +  AE LL +H   K EID H+DS++   ESG+ ++  
Sbjct: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130

Query: 431  GHYASDE----VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
                +D     + ++L  L     AL  +WE R     QC+  Q F +D +Q +  +S Q
Sbjct: 1131 ---QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ 1187

Query: 487  EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
            E  L + +  DSL++ EA ++K EDF  S+    +K+ +  +   KL+   +   + +  
Sbjct: 1188 EYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKE 1247

Query: 547  RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606
            +   +  R    +E+A      L D+  LQ F ++  EL  W+N+K+ T+ D +Y +  N
Sbjct: 1248 KVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307

Query: 607  LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
            L  K  KHQAF AEL++++  ++ ++  G++L+D        V+ ++  +  LW +L   
Sbjct: 1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQAT 1367

Query: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
            T+ K   L  A       +   D+  W+  +E  L SDD GKDLT+V  +  K   +E  
Sbjct: 1368 TKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ 1427

Query: 727  VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
            V   ++ +  +  Q     + G     +I+K       R+  L EP+  RK++L  S   
Sbjct: 1428 VNVRKEELGELFAQVPSMGEEGGDADLSIEK-------RFLDLLEPLGRRKKQLESSRAK 1480

Query: 787  QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK 846
             Q+ RD+EDE  W+ E+ P+A S + G +L  VQ  +KK+Q LQ EI GH PR++ V Q+
Sbjct: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540

Query: 847  GNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
            G  +VE      +D++ +L  L   W+ L+  A+ R Q L D+ +AQQY+ DA+EAE+W+
Sbjct: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600

Query: 907  REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-------QQ 959
             E+E  V S +  KDE+ A  +LK+H      +  YG +I+ L  +AQ          +Q
Sbjct: 1601 GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQ 1660

Query: 960  VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
            +     +  K     L D  E+  R+          L N  +    K E +D + ++   
Sbjct: 1661 IIRLQGQVDKHYA-GLKDVAEERKRK----------LENMYHLFQLKRETDDLEQWISEK 1709

Query: 1020 YVKKLDP--AQSASRENLLEEQ------GSIALRQEQIDNQTRITK--------EAGSVS 1063
             +    P   Q      LL ++       + A+ QE++DN     +        EA +++
Sbjct: 1710 ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIA 1769

Query: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
                 + E++  LLEL + R  +L  S      F    E+   I+EK   L  E+VG D 
Sbjct: 1770 EWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELP-EDVGLDA 1828

Query: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
               E   +    F+++L     +++    VA  L++     E+ +A+Q +E         
Sbjct: 1829 STAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT-AYAGEKAEAIQNKE--------- 1878

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQRFHRDA 1242
                                     +E++  W++L    A  R+QL+ +A +  RF   A
Sbjct: 1879 -------------------------QEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMA 1912

Query: 1243 DETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
             +   W+E   + + T     D++SV+ L + H+G   ++       ++  E  E L+Q 
Sbjct: 1913 RDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQR 1972

Query: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
              +++E+++EK  ++      + ++ + R  +L    ++ +F  D     +W+      +
Sbjct: 1973 QHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYL 2032

Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
            +S +    V   E L++RH+       + A  F A E+
Sbjct: 2033 ASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070



 Score =  474 bits (1220), Expect = e-133
 Identities = 363/1523 (23%), Positives = 705/1523 (46%), Gaps = 93/1523 (6%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73
            IQ+R   +   +     ++  R+ +LE S R   F  + +E E WI+EK QI S  +Y K
Sbjct: 608  IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGK 667

Query: 74   DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
            D T++    +KH+AFE E++     + ++ +  + M++   F    I  R+ E+  QW+ 
Sbjct: 668  DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQ 727

Query: 134  LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
            L +        L  A+   Q+  + +D+  W+ D   +++ E++GQD      L KK ++
Sbjct: 728  LKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKD 787

Query: 194  FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
            F  ++      +  + Q A    +E     ++    Q  +   +Q++   A  RQ +L  
Sbjct: 788  FLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ-ALRELYQQVVAQADLRQQRLQE 846

Query: 254  AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
            A ++     + D    W+ EKE+ +A  +    L  ++ +  + + L++++  L  ++  
Sbjct: 847  ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDG 906

Query: 314  LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
            +   A+ L +S    + +++  ++ L T W+  +TL +ER   ++ + R+  +  D  + 
Sbjct: 907  VNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966

Query: 374  TSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
            + W+T+  K + +  +L  D+AG  A+  +    + ++ A +    + +   Q L+ +  
Sbjct: 967  SKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026

Query: 433  YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492
               +++ ++   L E    L +  + +     +   LQ F +D +    W+S  +  + +
Sbjct: 1027 EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS 1086

Query: 493  EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN---HYAMEDVATRRD 549
            ED+ +SL   E LL++H   +  +   ++    + E   K+IQ      Y +  +  R +
Sbjct: 1087 EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--LGQRLE 1144

Query: 550  ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQG 609
             L +  NAL      R   LA     Q+F +D+ + ++ ++ +  T      + P +L+ 
Sbjct: 1145 GLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAH--LEPPDSLEA 1202

Query: 610  K---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
                ++K + F   +  N+ ++ +   +G KL+   +   D++  ++  +    +K  E 
Sbjct: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262

Query: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEA 725
             +   + LR+  + Q F +N +++ LW+ +    L S D   D   N+ N   KH    A
Sbjct: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVSYDEARNLHNKWLKHQAFVA 1320

Query: 726  DVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLR 785
            ++A+H+  ++ I  + +Q  D        + +K EAL   ++ L+     + Q L+ +  
Sbjct: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380

Query: 786  LQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
                 +   D   WI   E    S + GKDL  V  +L K + ++ ++   +  +  +  
Sbjct: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440

Query: 846  KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905
            +  +M EEG  A   ++ +  +L +          +R++ LE S    Q   D  +   W
Sbjct: 1441 QVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQLESSRAKLQISRDLEDETLW 1493

Query: 906  MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965
            + E+ P+  S DYG +  + +  +KK++ L +++  +   ++ + ++ Q    Q+    +
Sbjct: 1494 VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ----QLVEAAE 1549

Query: 966  ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025
               ++L   L   Q    R      G +  L ++     + ++ ++ + ++    +  + 
Sbjct: 1550 IDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI- 1608

Query: 1026 PAQSASRENLLEEQGSIAL------RQEQIDNQTRITKEAGSVS--------------LR 1065
                 S E   +E+G+I +      +Q  +++  R  K+  S +              +R
Sbjct: 1609 -----SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIR 1663

Query: 1066 MK-QVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
            ++ QV++ Y  L ++ E+RK  LE     F L RE ++L+QWI+EKE   +S E+G D +
Sbjct: 1664 LQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFD 1723

Query: 1125 QVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
             V +L+ KF DF ++  A  + R+ ++N   E L   G                      
Sbjct: 1724 HVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG---------------------H 1762

Query: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
            +++ T + WK                 LNE W  L +L + R QLL +++++ R+     
Sbjct: 1763 SEAATIAEWKDG---------------LNEMWADLLELIDTRMQLLAASYDLHRYFYTGA 1807

Query: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
            E    I+EK++ L  D  G D ++ ++  R H  FER+L  LG +V    + A RL  ++
Sbjct: 1808 EILGLIDEKHRELPED-VGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAY 1866

Query: 1304 P-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
              E AE +Q K  E++ AW +L      R+ +L D+ D  RF S  RDL+SW+  I   +
Sbjct: 1867 AGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI 1926

Query: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422
             + E  +DV+  E L++ HQ    EI+ R+  F A  + G+ LL   H AS EI++KL  
Sbjct: 1927 ETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQ 1986

Query: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482
            +   R ++ + W  R   L   LE+  F RD   AE W+ A+E +L + D G ++DSVE 
Sbjct: 1987 VMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046

Query: 1483 LIKKHEDFDKAINVQEEKIAALQ 1505
            LIK+HE F+K+     E+ AAL+
Sbjct: 2047 LIKRHEAFEKSTASWAERFAALE 2069



 Score =  463 bits (1191), Expect = e-129
 Identities = 383/1744 (21%), Positives = 783/1744 (44%), Gaps = 103/1744 (5%)

Query: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD 69
            E+ E+ + RR+  L           +R++KLE   R   F R A   E W+ E  ++ + 
Sbjct: 397  ESLEEAEYRRELALRN-------ELIRQEKLEQLARR--FDRKAAMRETWLSENQRLVAQ 447

Query: 70   ENYK-DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
            +N+  D   ++   +KH+A E +  A    +  L++    +  E +   + I  R   + 
Sbjct: 448  DNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNIL 507

Query: 129  RQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQ 188
            R W  L E ++ +  +L     L +  ++    +DW+++ +A + S E G+ L  VE L 
Sbjct: 508  RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLL 567

Query: 189  KKFEEFQTDMAAHEERVNEVNQFAAKLIQE---QHPEEELIKTKQDEVNAAWQRLKGLAL 245
            +K +  + D+A   ++V  +     K  +    Q  + ++I+ +   +   ++ L  +A 
Sbjct: 568  QKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAA 627

Query: 246  QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
             R+ +L  +  + +F  ++DE  SWIKEKEQ+ +S D+G+DL SV  L RKH+  E +L 
Sbjct: 628  GRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELR 687

Query: 306  ALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQR 365
             L+  ++ +  EA  +         QI+ + +E+   W+Q++ LAA     L D+    +
Sbjct: 688  GLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQ 747

Query: 366  FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
            F  D  DL +W+ +   L++ +++  D     AL  +H++   E++      +  ++  Q
Sbjct: 748  FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807

Query: 426  ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
                     S +V  +L  L E    ++   +LR+Q+ ++ +DL   + +T+  + WM +
Sbjct: 808  G-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866

Query: 486  QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVA 545
            +E +L   ++ D+L+ +E +  + +  ++ +     +I  ++  A  L+++ H    +V 
Sbjct: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926

Query: 546  TRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKD 603
              +D L +R  A       RR  +  +  +  +  D +E   W+ +K K   +T +  +D
Sbjct: 927  QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986

Query: 604  PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
             + +    +K    E +++A Q+R+DALE+  Q+L+D +   K+++  R   +  LW+ L
Sbjct: 987  LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046

Query: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
             ++ + +   L E +Q Q F ++++D + WL   +  +AS+D  + L   + L ++HA +
Sbjct: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106

Query: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAEN--IKKKQEALVARYEALKEPMVARKQKLA 781
            + ++  HQD    +  ++ +    G  D E   + ++ E L   + AL     +R   LA
Sbjct: 1107 KDEIDGHQDSYQRVK-ESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165

Query: 782  DSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841
              L  Q+  +D +  E  +  +E   A       L   +  ++K +     +  +  ++ 
Sbjct: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225

Query: 842  AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901
            +    GN +V EG+  ++ +K K+  +  +      KA +    L D+L+ Q +  +  E
Sbjct: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285

Query: 902  AESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYG---SSIQALREQAQSCR 957
               W+ +K  ++ S D   DE  +      KH+A +++L+++     +I A  +Q    +
Sbjct: 1286 LTLWINDK--LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEK 1343

Query: 958  QQVAPTDDETGKELVLALYDYQEKSPREVTM----KKGDILTLLNSTNKDWWKVEVNDRQ 1013
             Q      +   E +  L+D  + + +E T      +   L L    + + W   + D+ 
Sbjct: 1344 PQFTALVSQK-LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ- 1401

Query: 1014 GFVPAAYVKKLDPAQSASREN-----LLEEQGSIALRQEQID----NQTRITKEAGSVSL 1064
                   ++  DP +  +  N     L   +  + +R+E++         + +E G   L
Sbjct: 1402 -------LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454

Query: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
                +E+ +  LLE   +RK  LE S  K  + R+  +   W+ E+     S + G +L+
Sbjct: 1455 ---SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQ 1511

Query: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDET 1184
             V++  KK    Q ++  +  R++D+ +  + L    + A E+     +E  G       
Sbjct: 1512 TVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQL----VEAAEIDCQDLEERLG------- 1560

Query: 1185 DSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADE 1244
                                      L   W  L++ A  R Q L  A+E Q+++ DADE
Sbjct: 1561 -------------------------HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595

Query: 1245 TKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS-H 1303
             + WI E+   + +D    D      + ++H   +R +   G  +  L   A+ L+ + H
Sbjct: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGH 1655

Query: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
            PE  E +     ++++ ++ L   A++RK KL + + L +   +  DL  WI+    + S
Sbjct: 1656 PE-GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVAS 1714

Query: 1364 SDELAKDVTGAEALLERHQEHRTEIDA----RAGTFQAFEQFGQQLLAHGHYASPEIKQK 1419
            S E+ +D      L ++ ++   E  A    R     AF    ++L+  GH  +  I + 
Sbjct: 1715 SPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI---ERLIDAGHSEAATIAEW 1771

Query: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
             D L++  ADL +    R  +L    +L  +     +    +  +   L  ED G    +
Sbjct: 1772 KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL-PEDVGLDAST 1830

Query: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKA 1538
             E+  + H  F++ +++   ++   Q  A +L  A    K + I ++  EV   W+ L  
Sbjct: 1831 AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLD 1890

Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
                +R++L ++    +F     ++ +W+   ++    E+ + P ++   +LL K+  HQ
Sbjct: 1891 ACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI--ETQERPRDVSSVELLMKY--HQ 1946

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
               AE+   +      +++G SL++R   A  E  ++ +L  +  + + + +K   + ++
Sbjct: 1947 GINAEIETRSKNFSACLELGESLLQRQHQASEE--IREKLQQVMSRRKEMNEKWEARWER 2004

Query: 1659 LKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1718
            L+   +   F+      + WL   E  LAS D+G  + SV  L+K+H+  E   ++  +R
Sbjct: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064

Query: 1719 LKDL 1722
               L
Sbjct: 2065 FAAL 2068



 Score =  454 bits (1169), Expect = e-127
 Identities = 388/1785 (21%), Positives = 792/1785 (44%), Gaps = 132/1785 (7%)

Query: 146  LQAQKLVQ-YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQT--DMAAHE 202
            ++ +K+++ Y     D++ WI     ++ S +    L  V+   + F  ++T       +
Sbjct: 298  IETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQ 357

Query: 203  ERVN-EVNQFAAKLIQEQHPEEELIKTKQD-----EVNAAWQRL------KGLALQ---- 246
            E+ N EV  F  +         + + T  D     ++N AW+ L      + LAL+    
Sbjct: 358  EKGNLEVLLFTIQ--SRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415

Query: 247  RQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAA 306
            RQ KL   A  +RF+R      +W+ E ++L+A D+FG DLA+V+A  +KHE +E D AA
Sbjct: 416  RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAA 473

Query: 307  LEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRF 366
             E++V+AL   A  L++ +     +I  +++ ++  W  ++ L   R  RL  +  LQ+ 
Sbjct: 474  YEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKL 533

Query: 367  LADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQA 426
              D      W+ E+KA + + E    +   E LL +H+  + +I    D  K+   +   
Sbjct: 534  FQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLK 593

Query: 427  LLAAGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWM 483
                  Y   +   ++++++ L +    L  +   R+ Q EQ   L  F+ + ++ ++W+
Sbjct: 594  FTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWI 653

Query: 484  SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
             ++E    + D G  L SV  L +KH+ FE  L   +  +  + + A  ++    +    
Sbjct: 654  KEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ 713

Query: 544  VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY-K 602
            +  R   + ++ + L + A   +  L D+ +  QF  D+D+LK+W+ +  +  + E   +
Sbjct: 714  IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773

Query: 603  DPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKK 662
            D    +   +KH+ F  EL  ++  ++ LE+  Q   +    + D V  R+  +  L+++
Sbjct: 774  DEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELYQQ 832

Query: 663  LLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHAL 722
            ++   +L+  +L+EA          +  ELW+ E E  LA  +    L +++ +Q +  +
Sbjct: 833  VVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDI 892

Query: 723  LEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
            L+ ++     +IDG+ + A    ++GH  +  +K+ Q+ L  R++A +  +  R++ +  
Sbjct: 893  LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952

Query: 783  SLRLQQLFRDVEDEETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841
            +LR+     D E+   WI +K  +  ST + G+DL G+  + +K   L+ ++A  + R+ 
Sbjct: 953  ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVD 1012

Query: 842  AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901
            A+ ++   +++      ED+  +   L + W+ L+     +   L +  Q Q +  D ++
Sbjct: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDD 1072

Query: 902  AESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVA 961
             ++W+   +  V S D  +    AE LL++H  +  ++  +  S Q ++E  +   Q   
Sbjct: 1073 FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ--G 1130

Query: 962  PTDDE---TGKELV------LALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDR 1012
             TD E    G+ L        AL    E     +    G          KD  + E    
Sbjct: 1131 QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG-----FQEFQKDAKQAEAILS 1185

Query: 1013 QGFVPAAYVKKLDPAQSASR--ENLLEEQGSIALRQEQI----DNQTRITKEAGSVSLRM 1066
                  A+++  D  ++A        +  GS+   ++++    D+  ++  E    S ++
Sbjct: 1186 NQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKI 1245

Query: 1067 KQ----VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGAD 1122
            K+    +E+ +    E  ++   +L  + +     +   EL  WIN+K   LTS++V  D
Sbjct: 1246 KEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDVSYD 1303

Query: 1123 LEQVEVLQK--KFDDFQKDLKANESRLKDINK---------------VAEDLESEGLMAE 1165
             E   +  K  K   F  +L ++E  L++I+                V++ LE+   + +
Sbjct: 1304 -EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWD 1362

Query: 1166 EVQAVQQQEVYGMMPRDETDSKTAS-------------------PWKSARLMVHTVATFN 1206
            E+QA  +++   +     +D +  +                   P K    +   +A   
Sbjct: 1363 ELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLK 1422

Query: 1207 SIK--------ELNERWRSLQQLAEE---------------------RSQLLGSAHEVQR 1237
             ++        EL E +  +  + EE                     R + L S+    +
Sbjct: 1423 RVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQ 1482

Query: 1238 FHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297
              RD ++   W+EE+     + +YG +L +VQ   +K++  + ++     +V  + +  +
Sbjct: 1483 ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ 1542

Query: 1298 RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWING 1357
            +L+++     +DL+E+   L  +W  L + A  R  +L D+++ Q++  D  +  +WI  
Sbjct: 1543 QLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGE 1602

Query: 1358 IRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIK 1417
                V SDE+ KD  GA  +L+RH   +  ++      +      Q LL+ GH    +I 
Sbjct: 1603 QELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQII 1662

Query: 1418 QKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSL 1477
            +    +D+  A L+    +R+  L+    L    R+ +  E W++ +E   ++ + G   
Sbjct: 1663 RLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDF 1722

Query: 1478 DSVEALIKKHEDFDKAIN-VQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL 1536
            D V  L  K  DF +    + +E++  + AF ++LI AGH     I+  ++ + + W  L
Sbjct: 1723 DHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADL 1782

Query: 1537 KAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQK 1596
               +  +   L  S  L ++     EI   I EK +   ++   D +  +     S H+ 
Sbjct: 1783 LELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAE-----SFHRV 1837

Query: 1597 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEK 1655
            H AFE ELH    +++   D+   L  + A AG + +A++ +   ++  WQ L+   A +
Sbjct: 1838 HTAFERELHLLGVQVQQFQDVATRL--QTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895

Query: 1656 SQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAH 1715
              +L +   +  F +  +D   W+  +   + +++  +D++SV  L+K HQ + A+I   
Sbjct: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955

Query: 1716 EDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFF 1775
                       +SL+      + ++++K   +  R +++     +R  +L     + QF 
Sbjct: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015

Query: 1776 RDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
            RD    E+W+  ++  + S D+G  +  V+ L K+H+  E   A+
Sbjct: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060



 Score =  420 bits (1080), Expect = e-117
 Identities = 408/1856 (21%), Positives = 796/1856 (42%), Gaps = 139/1856 (7%)

Query: 372  DLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEIDAHEDSFKSA 420
            DL +W+ +   ++N+ + A+ + G +  L               + KG ++    + +S 
Sbjct: 313  DLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSR 372

Query: 421  DESGQALLAAGH---YASDEVR--EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
              +    +   H     SD  R  E L      R   L    +R+++ EQ    + F R 
Sbjct: 373  MRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLA--RRFDRK 430

Query: 476  TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
                + W+S+ +  +  ++ G  L +VEA  KKHE  E   +A EE++ AL++ A +L +
Sbjct: 431  AAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490

Query: 536  NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE-KMK 594
             N++  + +  R+D +L   + L E    RR +L  +  LQ+ F+D      W++E K  
Sbjct: 491  ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550

Query: 595  TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE---VAA 651
              + E  K    ++  +QKH+  EA+++    ++ A+  A  K  +   Y   +   +  
Sbjct: 551  LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610

Query: 652  RMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLT 711
            R++ +   +++L      +  +L ++ +  +F   +++ E W+ E E   +S DYGKDLT
Sbjct: 611  RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670

Query: 712  NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771
            +V  LQ+KH   E ++      ++ I  +A        F    I+ + + + A+++ LK+
Sbjct: 671  SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730

Query: 772  PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831
                 K+ L D+    Q   D +D + W+++   + +  + G+D    + L KKH+    
Sbjct: 731  LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790

Query: 832  EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891
            E+      ++ + Q+     EE    + DV  +L  L + ++ + A+A  R+Q L+++L 
Sbjct: 791  ELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849

Query: 892  AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
                F + +  E WM EKE  +   +     +  E +  + + L  ++    + I  +  
Sbjct: 850  LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909

Query: 952  QAQSCRQQVAPTDDETGK-----------------------ELVLALYDYQ---EKSPRE 985
             A S  +   P   E  +                       +  L +++Y    E++ + 
Sbjct: 910  AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969

Query: 986  VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKL-----DPAQSASRENLLEEQG 1040
            +T K     T +  + KD  +    D  G +  A  +KL     D A   +R + LE + 
Sbjct: 970  ITDK-----TKVVESTKDLGR----DLAGII--AIQRKLSGLERDVAAIQARVDALERES 1018

Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREA 1100
                 Q+ +D+     ++ G    R K +EEL+  L +  + ++ +L +  +     ++ 
Sbjct: 1019 -----QQLMDSHPEQKEDIGQ---RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070

Query: 1101 NELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESE 1160
            ++ Q W++  + A+ SE++   L + E L ++    + ++  ++   + + +  E +   
Sbjct: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV--- 1127

Query: 1161 GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ 1220
                  +Q     E   +  R                          ++ L+  W +L +
Sbjct: 1128 ------IQGQTDPEYLLLGQR--------------------------LEGLDTGWNALGR 1155

Query: 1221 LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFER 1280
            + E RS  L      Q F +DA + +  +  +   L        L + +A  RK E F  
Sbjct: 1156 MWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLG 1215

Query: 1281 DLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD 1340
             +    DKV S  ++  +L+      ++ ++EK   +        ++A +    L D+ +
Sbjct: 1216 SMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE 1275

Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
            LQ FL + ++L  WIN  + L S D    +         +HQ    E+ +  G  +  + 
Sbjct: 1276 LQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334

Query: 1401 FGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENW 1460
             G+QL+      +  + QKL+ L +   +L+    ++   L       L  +       W
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394

Query: 1461 MAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG 1520
            ++A E  L ++D G  L SV  ++ K +  +  +NV++E++  L A    +   G  A  
Sbjct: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454

Query: 1521 DISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYK 1580
             I  R  ++L+   R K Q+   R+KL       Q SRD+++   W+ E+L  A    Y 
Sbjct: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKL-------QISRDLEDETLWVEERLPLAQSADYG 1507

Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
              TN+Q  +L  K  K+Q  + E+  +  R+  V+  G  L+E       +  ++ RL  
Sbjct: 1508 --TNLQTVQLFMK--KNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD--LEERLGH 1561

Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNN 1700
            L   W  L + +A + Q+L++AN+ Q +     + + W+ E E  + S++  KD      
Sbjct: 1562 LQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIV 1621

Query: 1701 LLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAAS 1760
            +LK+H   +  +  +   +K L S+A  L+++   +  Q+   +  ++  +  +K +A  
Sbjct: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEE 1681

Query: 1761 RRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
            R+ KL   + L Q  R+ DD E WI EK+L+  S + G+D   V  LR K +    E  A
Sbjct: 1682 RKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGA 1741

Query: 1821 -HEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQ 1879
              +  +  V    ++L D        I +      E W +L +L   R Q L  S +  +
Sbjct: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801

Query: 1880 FVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT---VHKDRVNDVCT 1936
            +     E    I+EK   +  ED G   +  +   + H AFE +     V   +  DV T
Sbjct: 1802 YFYTGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860

Query: 1937 NGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESW 1996
              Q          E I +K + ++     L  A A R+ +L + +   +F   A  + SW
Sbjct: 1861 RLQTAYA--GEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSW 1918

Query: 1997 IGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQS 2056
            +      ++T +  RD+SSV+ L+   +  +A ++  + +  +    L + LL  +H  S
Sbjct: 1919 MESIIRQIETQERPRDVSSVELLMKYHQGINAEIET-RSKNFSACLELGESLLQRQHQAS 1977

Query: 2057 KAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAE 2116
            + I  +   +M R  ++     AR ++L       R + ++   F++ AS   +W    E
Sbjct: 1978 EEIREKLQQVMSRRKEMNEKWEARWERL-------RMLLEV-CQFSRDASVAEAWLIAQE 2029

Query: 2117 EDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE-LDRQIKSFRVASNP 2171
              L      ++++ ++ L + H+AF  S +S    F  L +    ++K  ++A  P
Sbjct: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085



 Score =  280 bits (715), Expect = 2e-74
 Identities = 224/998 (22%), Positives = 448/998 (44%), Gaps = 60/998 (6%)

Query: 4    SGVKVLETAED-----IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEK 58
            SG KV++   D     + +R + +   ++    +   R   L     FQ FQ+DA++ E 
Sbjct: 1123 SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEA 1182

Query: 59   WIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS 117
             +  ++  +A  E        +  ++K + F   ++ N   ++   ++GN +++EG+  S
Sbjct: 1183 ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242

Query: 118  ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEEL 177
            + I+ ++  +  +     EK +E  + L    +L  +L+ C+++  WINDK  ++TS+++
Sbjct: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDV 1300

Query: 178  GQD-LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236
              D   ++     K + F  ++A+HE  +  ++    +L+ E+     L+  K + ++  
Sbjct: 1301 SYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRL 1360

Query: 237  WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
            W  L+    ++   L  A       +   +   WI   E  + SDD G+DL SV  +L K
Sbjct: 1361 WDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAK 1420

Query: 297  HEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHAR 356
             + +E  +   ++++  L A+   + +    +   I+ +  +L+            R  +
Sbjct: 1421 LKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQ 1473

Query: 357  LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416
            L  S    +   D  D T WV E   L  + +  +++   +  + ++Q  + EI  H   
Sbjct: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533

Query: 417  FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476
             +   + GQ L+ A      ++ E+L  L      L E    R Q+     + Q +Y D 
Sbjct: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593

Query: 477  EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN 536
            ++ + W+ +QE +++++++    +    +LK+H   ++++      I  L   A  L+  
Sbjct: 1594 DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA 1653

Query: 537  NHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA 596
             H   E +   +  +      L + A  R+ +L + +HL Q  R++D+L+ W++EK   A
Sbjct: 1654 GHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVA 1713

Query: 597  TD-EAYKDPSNLQGKVQKHQAFEAELSA-NQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
            +  E  +D  ++     K + F  E  A  Q R+D +    ++LID  H     +A   +
Sbjct: 1714 SSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKD 1773

Query: 655  EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714
             +  +W  LLE  + +   L  +    ++     +I L L + +     +D G D +  +
Sbjct: 1774 GLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI-LGLIDEKHRELPEDVGLDASTAE 1832

Query: 715  NLQKKHALLEADVAAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVAR 765
            +  + H   E ++         + +Q +QFQD         AG   AE I+ K++ + A 
Sbjct: 1833 SFHRVHTAFERELHL-------LGVQVQQFQDVATRLQTAYAGE-KAEAIQNKEQEVSAA 1884

Query: 766  YEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKK 825
            ++AL +    R+ +L D+    + F    D  +W+        +  R +D+  V+ L+K 
Sbjct: 1885 WQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKY 1944

Query: 826  HQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH-------ELNQKWEALKAK 878
            HQ + AEI        A  + G ++++  H A+E+++ KL        E+N+KWEA    
Sbjct: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA---- 2000

Query: 879  ASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD 938
               R + L   L+  Q+  DA+ AE+W+  +EP + S D+G   DS E L+K+HEA    
Sbjct: 2001 ---RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKS 2057

Query: 939  LSAYGSSIQAL----------REQAQSCRQQVAPTDDE 966
             +++     AL          R+ A+   ++  P ++E
Sbjct: 2058 TASWAERFAALEKPTTLELKERQIAERPAEETGPQEEE 2095



 Score =  216 bits (551), Expect = 2e-55
 Identities = 195/864 (22%), Positives = 366/864 (42%), Gaps = 71/864 (8%)

Query: 1544 RSKLGESQTLQQFSRDVDEI----EAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
            R++L   + L+Q +R  D      E W+SE  +  + +++       L+ + +  +KH+A
Sbjct: 411  RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF----GYDLAAVEAAKKKHEA 466

Query: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
             E +  A  +R+R + D+   L +       +  + AR   +   W +L +    + Q+L
Sbjct: 467  IETDTAAYEERVRALEDLAQELEKENY--HDQKRITARKDNILRLWSYLQELLQSRRQRL 524

Query: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719
            +     Q     +     W+ E++A L S ++GK L  V +LL+KH+L+EADI+   D++
Sbjct: 525  ETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKV 584

Query: 1720 KDLNSQADSLMTSSAF---DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFR 1776
            K + +          +   D   ++D+   +   F+++ +MAA R+A+L +S RL +FF 
Sbjct: 585  KAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFW 644

Query: 1777 DMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLS 1836
            +MD+ ESWIKEK+ +  S DYG+DLT V  L++KHK  E EL   +  ++ +      + 
Sbjct: 645  EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704

Query: 1837 DDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT 1896
                 G  +I+ R+ +    W +LK LAA   + L+++  + QF  + ++ +AW+ +   
Sbjct: 705  ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHR 764

Query: 1897 LVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKM 1956
            L++ ED G    A + L KKH+ F  +    +  +  +    Q    +      +++ ++
Sbjct: 765  LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRL 823

Query: 1957 KGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSV 2016
            + L      +   A  R+ +L E         + D  E W+GEKE  L   +    L  +
Sbjct: 824  QALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDL 883

Query: 2017 QTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLAN 2076
            + +  + +  D  ++    + I  +    + L+ + H +S+ ++     L  RW      
Sbjct: 884  EVVQHRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTL 942

Query: 2077 SAARKKKL---LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2133
             + R++ +   L   ++    E+       K     S      +DL        L  I A
Sbjct: 943  VSERREAVDSALRVHNYCVDCEETSKWITDKTKVVES-----TKDLG-----RDLAGIIA 992

Query: 2134 LREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
            ++         +++ QA  + L    +Q+               + LEE W+ LQ+    
Sbjct: 993  IQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ---- 1048

Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEAT 2253
                LQ ++    E  +L Q F Q  + F  W+  T+  +     M E     E  L+  
Sbjct: 1049 ---SLQGQEDLLGEVSQL-QAFLQDLDDFQAWLSITQKAVASED-MPESLPEAEQLLQQH 1103

Query: 2254 KRKHQEIRAMRSQLKKIEDLGAAM------EEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307
                 EI   +   +++++ G  +       E L+L  +       GL   W+ L ++  
Sbjct: 1104 AGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLE-----GLDTGWNALGRMWE 1158

Query: 2308 RMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKD---KSGRLNHQEFKSCLRSLGYDL 2364
               H L Q                   + F+ F KD       L++QE+          L
Sbjct: 1159 SRSHTLAQ------------------CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200

Query: 2365 PMVEEGEPDPEFEAILDTVDPNRD 2388
               E G    +FE  L +++ NRD
Sbjct: 1201 EAAEAG--IRKFEDFLGSMENNRD 1222



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 15/247 (6%)

Query: 2078 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2137
            A   K++ +   H  + E +   ++  AS   +W E     L      NSL  ++   +A
Sbjct: 284  AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343

Query: 2138 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASN-----PYTWFTMEALEETWRNLQKII 2191
               +R+     +  +   L  L   I+S   A+N     P+    +  +   W +L++  
Sbjct: 344  FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403

Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2251
              REL L+ E  RQE+ ++L + F + A     W+ E +  +       +  G   + +E
Sbjct: 404  YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQ-----DNFGYDLAAVE 458

Query: 2252 ATKRKHQEIR----AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307
            A K+KH+ I     A   +++ +EDL   +E+    D K        + + W  L +L  
Sbjct: 459  AAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQ 518

Query: 2308 RMQHNLE 2314
              +  LE
Sbjct: 519  SRRQRLE 525



 Score = 45.1 bits (105), Expect = 9e-04
 Identities = 75/396 (18%), Positives = 152/396 (38%), Gaps = 38/396 (9%)

Query: 1995 SWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA--FQQEGIANITALKDQLLAAK 2052
            +WI +    L +  +   L+ VQ  L    T+    +   FQ++G  N+  L   + +  
Sbjct: 316  TWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG--NLEVLLFTIQSRM 373

Query: 2053 HVQSKAIEARH-----ASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASA 2107
               ++ +   H     + + + W  L      R+  L        K+E L   F +KA+ 
Sbjct: 374  RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAM 433

Query: 2108 FNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRV 2167
              +W    +  +        L  ++A ++ H+A  +  ++ +     L +L ++++    
Sbjct: 434  RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493

Query: 2168 ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQ 2227
                      + +   W  LQ++++ R   L+     Q    KL Q+     +    W+ 
Sbjct: 494  HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQ----KLFQDMLHSID----WMD 545

Query: 2228 ETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA-MRSQLKKIEDLGAAM------EEA 2280
            E + +LL       E G    ++E   +KH+ + A +  Q  K++ + AA       +  
Sbjct: 546  EIKAHLLSA-----EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600

Query: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA---LKEFSMMF 2337
               D +  +     L Q +++L  +    +  LEQ  +        +EA   +KE   ++
Sbjct: 601  QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660

Query: 2338 KHFD--KDKSGRL----NHQEFKSCLRSLGYDLPMV 2367
               D  KD +  L     H+ F+  LR L   L  +
Sbjct: 661  SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQI 696


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score =  558 bits (1439), Expect = e-158
 Identities = 447/1782 (25%), Positives = 793/1782 (44%), Gaps = 142/1782 (7%)

Query: 582  SDELKSWVNEKMKTATDEAYKDP-SNLQGKVQKHQAF----------------------E 618
            + EL  W+ + + T  D    +  S +Q ++Q   ++                      +
Sbjct: 314  ASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQ 373

Query: 619  AELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN 678
            ++L AN  ++    + G+ + D+N   +    A     ++L  +L+   +L+ +  R   
Sbjct: 374  SKLRANNQKVYT-PREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAAR--- 429

Query: 679  QQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGIT 738
                F+R     E WL E +  ++ D++G +L  V+   +KH  +E D+ A+  R+  + 
Sbjct: 430  ----FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVD 485

Query: 739  IQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEET 798
              A +     + D + I  +Q  +   ++ L++ + AR+++L  +L LQ++F+D+     
Sbjct: 486  AVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMD 545

Query: 799  WIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGH--- 855
            W+ E +    S + G+ L GV++LL+ H+ ++A+IA    R++AV+         G    
Sbjct: 546  WMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR 605

Query: 856  -FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVG 914
                + V  ++ +L Q +EAL   A+ RR  LE+S +  ++  +  EAE+W+RE++ ++ 
Sbjct: 606  PCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLA 665

Query: 915  STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLA 974
            S D G+D   A  LL KH AL  ++S     ++   EQ Q    +  P   +        
Sbjct: 666  SADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAA-- 723

Query: 975  LYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY-------------- 1020
              + Q +  R   + +     L  + +   ++ + ND + ++  A               
Sbjct: 724  --ELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFS 781

Query: 1021 VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG 1080
             + L     A  E +   + ++   +EQ             V  R+  +E  Y  L    
Sbjct: 782  TQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARA 841

Query: 1081 EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL 1140
             +R   LE +   + +  EA     W+ EKE  L    +   LE +EV+Q++F+  + ++
Sbjct: 842  GERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEM 901

Query: 1141 KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH 1200
                +++  +N +AE L                               A+P    R++  
Sbjct: 902  NTLAAQITAVNDIAEQLLK-----------------------------ANPPGKDRIV-- 930

Query: 1201 TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQAL-NTD 1259
                 N+ ++LN RW+  ++LA+ +   L SA  +Q +H +  ET+ W+ EK + + +T 
Sbjct: 931  -----NTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQ 985

Query: 1260 NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQ 1319
              G+DLA V ALQRK  G ERDL A+  +V  L   A  L   HP  A  +  +  E+  
Sbjct: 986  GLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQT 1045

Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLE 1379
             W  L     +R+  LG++  LQ FL    D  +W+   +  V+S+E    +  AEALL 
Sbjct: 1046 GWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLA 1105

Query: 1380 RHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQKLDILDQERADLEKAWVQ 1436
            +H   R E++     +      G+++      A P+   ++Q+L+ L     +L + W  
Sbjct: 1106 QHAALRGEVERAQSEYSRLRALGEEVTRD--QADPQCLFLRQRLEALGTGWEELGRMWES 1163

Query: 1437 RRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINV 1496
            R+  L Q    Q F RD  QAE  ++++E  L+  +   +L + +A IKK EDF   ++ 
Sbjct: 1164 RQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDA 1223

Query: 1497 QEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQF 1556
              E+I  L     QL++ G+     I  + + +  R ++ +    +   +L +++  Q F
Sbjct: 1224 NGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHF 1283

Query: 1557 SRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVID 1616
             +D  E++ WI EK+ TA D SY +  N+      +K QKHQAF AEL AN D +  V  
Sbjct: 1284 LQDCHELKLWIDEKMLTAQDVSYDEARNLH-----TKWQKHQAFMAELAANKDWLDKVDK 1338

Query: 1617 MGNSL-IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDF 1675
             G  L +E+         V  +L  L  +W  L   +  K++ L +AN+ + F       
Sbjct: 1339 EGRELTLEKPELKA---LVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCAL 1395

Query: 1676 DFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAF 1735
            + WL  ++A L S+DYGKDL SVN LLKK Q+LE +++  E  ++ + +QA +L      
Sbjct: 1396 ESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ- 1454

Query: 1736 DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSE 1795
               +V+     +  +F+ +      R  +L  S   HQF RD++DE  W+ E+  +  S 
Sbjct: 1455 GAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSM 1514

Query: 1796 DYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVE 1855
            ++G+DL  VQ L KK++ L+ E+  HEP I  + +  + L      G       LA+  E
Sbjct: 1515 EHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL------GAAAAGPELAELQE 1568

Query: 1856 HWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLL 1914
             WK L      RG+RLE++L  QQF  +  E EAW+ E ++ ++  E   D L+A Q  +
Sbjct: 1569 MWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSA-QAEV 1627

Query: 1915 KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRK 1974
            KKH+  E     +   ++ +  + QD+I   +     IS +   ++   + L++ A +R+
Sbjct: 1628 KKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERR 1687

Query: 1975 AKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQ 2034
             +L E+    Q   + D +E WI E+E    + + G+D   V  L  K   F        
Sbjct: 1688 ERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIG 1747

Query: 2035 QEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKV 2094
            QE + +  AL + L+A  H     +     SL + W+ LL     R + L  A    R  
Sbjct: 1748 QERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQR-- 1805

Query: 2095 EDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQ 2154
               FL  A++A A     ++ ++ L D      L   +AL+  H A+   + +      Q
Sbjct: 1806 ---FLHGARQALA---RVQHKQQQLPDGTG-RDLNAAEALQRRHCAYEHDIQALSPQVQQ 1858

Query: 2155 LAELDRQI-KSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQ 2213
            + +   ++ K++           M+A+ E W  LQ     R       Q   +  DK R 
Sbjct: 1859 VQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAAR------RQLLLDTTDKFR- 1911

Query: 2214 EFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDL 2273
             F +       W+ E     +D      +  + +  ++  +    EI A   +     D+
Sbjct: 1912 -FFKAVRELMLWMDEVNLQ-MDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDM 1969

Query: 2274 GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQ 2315
            G   +E L   +   E  +       ++L QL  R Q   E+
Sbjct: 1970 G---KELLARSHYAAEEIS-------EKLSQLQARRQETAEK 2001



 Score =  521 bits (1341), Expect = e-147
 Identities = 384/1412 (27%), Positives = 668/1412 (47%), Gaps = 75/1412 (5%)

Query: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ-IASDE 70
            A     R  ++  ++ R + L+  R Q+L  +     FQ DA ++E W+ + L+ ++S E
Sbjct: 715  ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE 774

Query: 71   NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
               D  + Q   ++H+A E E++++   +  L E    +        E ++ R+  L R 
Sbjct: 775  LGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERH 833

Query: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
            +E L  +  E+   L  A  L   L E      W+ +KE  +    L + LE +EV+Q++
Sbjct: 834  YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQR 893

Query: 191  FEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK 250
            FE  + +M     ++  VN  A +L++   P ++ I   Q+++N  WQ+ + LA  ++  
Sbjct: 894  FETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAA 953

Query: 251  LFGAAEVQRFNRDVDETISWIKEKEQLMASDD-FGRDLASVQALLRKHEGLERDLAALED 309
            L  A  +Q ++ +  ET +W++EK +++ S    G DLA V AL RK  G ERDL A+  
Sbjct: 954  LTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAA 1013

Query: 310  KVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLAD 369
            +V  L  EA+ L   HP  A  I  +  E+ T WE +R     R   L ++ RLQ FL  
Sbjct: 1014 RVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRS 1073

Query: 370  FRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLA 429
              D  +W+   +  + ++E  + +  AEALL +H   +GE++  +  +      G+ +  
Sbjct: 1074 LDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR 1133

Query: 430  AGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
                A  +   +R++L  L      L  +WE R+ +  Q    Q F RD  Q +  +S Q
Sbjct: 1134 --DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQ 1191

Query: 487  EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
            E  L + ++  +L + +A +KK EDF  ++ A  E+I  L E   +L+   +   + +  
Sbjct: 1192 EYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251

Query: 547  RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606
            + D++  R     + A +   +L D+   Q F +D  ELK W++EKM TA D +Y +  N
Sbjct: 1252 KADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARN 1311

Query: 607  LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
            L  K QKHQAF AEL+AN+  +D ++K G++L       K  V+ ++ ++   W +L   
Sbjct: 1312 LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETT 1371

Query: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
            T+ K   L +AN+ + F ++   +E WL  ++  L SDDYGKDLT+V  L KK  +LE +
Sbjct: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWE 1431

Query: 727  VAAHQDRIDGITIQARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
            +A  +  ++ I  QA+    +D G   A  +++   A+  ++ AL +PM  R ++L  S 
Sbjct: 1432 MAVREKEVEAIQAQAKALAQEDQG---AGEVERTSRAVEEKFRALCQPMRERCRRLQASR 1488

Query: 785  RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVT 844
               Q  RDVEDE  W+ E+ P+A+S   GKDL  VQ L+KK+Q LQ EI GHEPRI  + 
Sbjct: 1489 EQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLR 1548

Query: 845  QKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAES 904
            ++  A+       A     +L EL + W+ L  +   R + LED+L+AQQ++ DA EAE+
Sbjct: 1549 ERQRAL------GAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEA 1602

Query: 905  WMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
            WM E+E  +   +  KDE SA+A +KKH+ L   L+ Y  +I  L   +Q       P  
Sbjct: 1603 WMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHP-- 1660

Query: 965  DETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYV--K 1022
            + T   +  A  D      +E+  ++ +   L         + E++D + ++    V   
Sbjct: 1661 ESTRISIRQAQVDKLYAGLKELAGERRE--RLQEHLRLCQLRRELDDLEQWIQEREVVAA 1718

Query: 1023 KLDPAQSASRENLLEE------QGSIALRQEQIDNQTRITKE--AGSVSLRMKQVE---- 1070
              +  Q      +L +      + +  + QE++D+   +     AG  + R    E    
Sbjct: 1719 SHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDS 1778

Query: 1071 --ELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEV 1128
              E +  LLEL + R  +L  + +       A +    +  K+  L  +  G DL   E 
Sbjct: 1779 LNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEA 1837

Query: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
            LQ++   ++ D++A       ++   + ++ +G   ++  A  + E  G           
Sbjct: 1838 LQRRHCAYEHDIQA-------LSPQVQQVQDDGHRLQKAYAGDKAEEIG----------- 1879

Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248
                               ++ + E W  LQ  +  R QLL    +  RF +   E   W
Sbjct: 1880 -----------------RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLW 1922

Query: 1249 IEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE 1308
            ++E N  ++      D++S   + +  +G + ++ A  D+ +S  +  + L+     +AE
Sbjct: 1923 MDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAE 1982

Query: 1309 DLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELA 1368
            ++ EK ++L        ++  ++   L    ++  F  D     +W+     LV S EL 
Sbjct: 1983 EISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELG 2042

Query: 1369 KDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
              V   E+L++RH+  +    A    F A E+
Sbjct: 2043 CTVDEVESLIKRHEAFQKSAVAWEERFCALEK 2074



 Score =  499 bits (1284), Expect = e-140
 Identities = 394/1525 (25%), Positives = 705/1525 (46%), Gaps = 97/1525 (6%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI-ASDENYK 73
            + ER  ++   Y    EL+  RR +LE+S R   F  +  E E W++E+  + AS +  +
Sbjct: 612  VSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR 671

Query: 74   DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
            D T     L KH A   E+    G +    E G  +++EGH  +     R  EL  QWE 
Sbjct: 672  DLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWER 731

Query: 134  LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
            L     E+  +L QA  L Q+  +  D+  W+ D   +V+S ELG D    + L ++   
Sbjct: 732  LEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRA 791

Query: 194  FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
             + ++ +H   ++ + + AA L        E ++ +   +   ++ L+  A +R   L  
Sbjct: 792  LEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERHYEELQARAGERARALEA 850

Query: 254  AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
            A  +     +      W++EKEQ +        L  ++ + ++ E LE ++  L  ++ A
Sbjct: 851  ALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITA 910

Query: 314  LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
            +   A++L +++P    +I   +E+L   W+Q R LA  + A L  +  +Q +  +  + 
Sbjct: 911  VNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTET 970

Query: 374  TSWVTEMKALINADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
             +W+ E   +I + + L +D+AG  AL  +    + +++A             AL AAGH
Sbjct: 971  QAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANAL-AAGH 1029

Query: 433  YA-----SDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQE 487
             A     +  +RE  T   + RA +      R +   +   LQ F R  +    W+ + +
Sbjct: 1030 PAQAVAINARLREVQTGWEDLRATMRR----REESLGEARRLQDFLRSLDDFQAWLGRTQ 1085

Query: 488  AFLLNEDLGDSLDSVEALLKKHEDFEKSLS-AQEE--KITALDEFATKLIQNNHYAMEDV 544
              + +E+   +L   EALL +H      +  AQ E  ++ AL E  T+   +       +
Sbjct: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLF--L 1143

Query: 545  ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP 604
              R +AL +    L      R+ +LA +   Q F RD+ + +  ++ +    +      P
Sbjct: 1144 RQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEM--P 1201

Query: 605  SNLQGK---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWK 661
              LQ     ++K + F + + AN  RI  L +AG++L+   +   D++  + + +    K
Sbjct: 1202 GTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHK 1261

Query: 662  KLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKH 720
            K  +A +    +LR+  +QQ F ++  +++LW+ E    L + D   D   N+    +KH
Sbjct: 1262 KNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKM--LTAQDVSYDEARNLHTKWQKH 1319

Query: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
                A++AA++D +D +  + R+           + +K   L  R++ L+    A+ + L
Sbjct: 1320 QAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379

Query: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
             D+ R +   +     E+W+   +    S + GKDL  V  LLKK Q L+ E+A  E  +
Sbjct: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439

Query: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
            +A+  +  A+ +E   A E V+     + +K+ AL     +R + L+ S +  Q+  D  
Sbjct: 1440 EAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVE 1498

Query: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV 960
            +   W+ E+ P+  S ++GKD  S + L+KK++ L  ++  +   I  LRE+ ++     
Sbjct: 1499 DEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAA 1558

Query: 961  APTD--------DETGKELVL----------ALYDYQEKSPREVTMKKGDILTLLNSTNK 1002
            A  +           G EL L          A   Y++ +  E  M + ++  +     K
Sbjct: 1559 AGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAK 1618

Query: 1003 DWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSV 1062
            D    +          A VKK    + A  +         A  Q+ ID++     E+  +
Sbjct: 1619 DELSAQ----------AEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEH---PESTRI 1665

Query: 1063 SLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGAD 1122
            S+R  QV++LY  L EL  +R+  L++  +   L RE ++L+QWI E+E    S E+G D
Sbjct: 1666 SIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQD 1725

Query: 1123 LEQVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPR 1181
             E V +L+ KF +F +D     + R+   N +A  L + G  A                 
Sbjct: 1726 YEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA--------------- 1770

Query: 1182 DETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRD 1241
                  T + WK +               LNE W  L +L + R Q+L +A+E+QRF   
Sbjct: 1771 ------TVAEWKDS---------------LNEAWADLLELLDTRGQVLAAAYELQRFLHG 1809

Query: 1242 ADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQ 1301
            A +    ++ K Q L  D  G DL + +ALQR+H  +E D+ AL  +V  + +   RL +
Sbjct: 1810 ARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK 1868

Query: 1302 SHP-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRG 1360
            ++  + AE++      + +AW+ L   +  R+  L D+ D  RF    R+LM W++ +  
Sbjct: 1869 AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNL 1928

Query: 1361 LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKL 1420
             + + E  +DV+ A+ +++  Q  + EI+ARA  F +    G++LLA  HYA+ EI +KL
Sbjct: 1929 QMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKL 1988

Query: 1421 DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSV 1480
              L   R +  + W ++   L   LE+ +F RD   AE W+ ++E  + + + G ++D V
Sbjct: 1989 SQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEV 2048

Query: 1481 EALIKKHEDFDKAINVQEEKIAALQ 1505
            E+LIK+HE F K+    EE+  AL+
Sbjct: 2049 ESLIKRHEAFQKSAVAWEERFCALE 2073



 Score =  446 bits (1146), Expect = e-124
 Identities = 399/1724 (23%), Positives = 756/1724 (43%), Gaps = 113/1724 (6%)

Query: 35   LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYK-DPTNLQGKLQKHQAFEAEVQ 93
            +R++KLE       F R A   E W+ E  ++ S +N+  +   ++  ++KH+A E ++ 
Sbjct: 418  IRQEKLEQLAAR--FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIV 475

Query: 94   ANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ 153
            A SG +  +D     + +E +   + I  R   + R W+ L + +  +  +LL   +L +
Sbjct: 476  AYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQK 535

Query: 154  YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAA 213
              ++   +MDW+ + +  + S++LG+ L  VE L +  E  + D+A   ERV  V+  A 
Sbjct: 536  VFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASAL 595

Query: 214  KLI---QEQHP-EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS 269
            +     +E  P + +L+  +  ++  +++ L  LA  R+ +L  +  + RF  +V E  +
Sbjct: 596  RFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEA 655

Query: 270  WIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL-QQSHPLS 328
            W++E++ L+AS D GRDL     LL KH  L  +++     +K    +  +L  + HP  
Sbjct: 656  WVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHP-G 714

Query: 329  ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
            A+Q   +  EL   WE++  LA ER  RL  +  L +F AD  D+ +W+ +   L+++ E
Sbjct: 715  ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPE 774

Query: 389  LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEE 448
            L  D    +AL  +H+  + EI +H  +  +  E   A L      + EV+ ++  L   
Sbjct: 775  LGHDEFSTQALARQHRALEEEIRSHRPTLDALREQA-AALPPTLSRTPEVQGRVPTLERH 833

Query: 449  RAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKK 508
               L      R +  E  + L     +      W+ ++E +L    L + L+ +E + ++
Sbjct: 834  YEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQR 893

Query: 509  HEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQ 568
             E  E  ++    +ITA+++ A +L++ N    + +   ++ L  R       A  ++A 
Sbjct: 894  FETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAA 953

Query: 569  LADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKDPSNLQGKVQKHQAFEAELSANQS 626
            L  +  +Q +  +  E ++W+ EK K   +T     D + +    +K    E +L A  +
Sbjct: 954  LTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAA 1013

Query: 627  RIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRN 686
            R+  L +    L   +      + AR+ EV + W+ L      +   L EA + Q F R+
Sbjct: 1014 RVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRS 1073

Query: 687  VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF-Q 745
            ++D + WL   +  +AS++    L   + L  +HA L  +V   Q     +     +  +
Sbjct: 1074 LDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTR 1133

Query: 746  DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
            D        ++++ EAL   +E L     +R+ +LA +   Q   RD    E  +  +E 
Sbjct: 1134 DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEY 1193

Query: 806  IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
            + + T     L      +KK +   + +  +  RI  + + G  +V EG+  A+ ++ K 
Sbjct: 1194 VLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKA 1253

Query: 866  HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDE-DS 924
              + ++ +  +  A Q    L D+ + Q +  D +E + W+ EK  ++ + D   DE  +
Sbjct: 1254 DSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEK--MLTAQDVSYDEARN 1311

Query: 925  AEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVL----------- 973
                 +KH+A M++L+A    +  +               D+ G+EL L           
Sbjct: 1312 LHTKWQKHQAFMAELAANKDWLDKV---------------DKEGRELTLEKPELKALVSE 1356

Query: 974  ALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA--AYVKKLDPAQSAS 1031
             L D   +     T  +    +L ++   + +       + ++ +  A +   D  +  +
Sbjct: 1357 KLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416

Query: 1032 RENLLEE-----QGSIALRQEQIDNQTRITKE-------AGSVSLRMKQVEELYHSLLEL 1079
              N+L +     +  +A+R+++++      K        AG V    + VEE + +L + 
Sbjct: 1417 SVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQP 1476

Query: 1080 GEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKD 1139
              +R   L+ S ++    R+  +   W+ E+    +S E G DL  V++L KK    QK+
Sbjct: 1477 MRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKE 1536

Query: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
            ++ +E R+ D+                    ++Q   G        +  A P        
Sbjct: 1537 IQGHEPRIADLR-------------------ERQRALG--------AAAAGP-------- 1561

Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
                    + EL E W+ L    E R + L  A   Q+F+RDA E + W+ E+   +   
Sbjct: 1562 -------ELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQ 1614

Query: 1260 NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI-QSHPESAEDLQEKCTELN 1318
                D  S QA  +KH+  E+ LA     ++ L  +++ +I   HPES   +  +  +++
Sbjct: 1615 EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTR-ISIRQAQVD 1673

Query: 1319 QAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
            + ++ L + A +R+ +L +   L +   +  DL  WI     + +S EL +D      L 
Sbjct: 1674 KLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLR 1733

Query: 1379 ERHQE-HRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQR 1437
            ++ +E  R           +       L+A GH A   + +  D L++  ADL +    R
Sbjct: 1734 DKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTR 1793

Query: 1438 RMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQ 1497
              +L    ELQ F     QA   +  ++  L  +  G  L++ EAL ++H  ++  I   
Sbjct: 1794 GQVLAAAYELQRFLHGARQALARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQAL 1852

Query: 1498 EEKIAALQAFADQL--IAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQ 1555
              ++  +Q    +L    AG  A+ +I      V + W +L+     +R  L ++    +
Sbjct: 1853 SPQVQQVQDDGHRLQKAYAGDKAE-EIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFR 1911

Query: 1556 FSRDVDEIEAWISE-KLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGV 1614
            F + V E+  W+ E  LQ  + E    P ++  + L+ K+Q  Q  +AE+ A ADR    
Sbjct: 1912 FFKAVRELMLWMDEVNLQMDAQER---PRDVSSADLVIKNQ--QGIKAEIEARADRFSSC 1966

Query: 1615 IDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKD 1674
            IDMG  L+ R   A  E  +  +L+ L  + Q   +K  EK   L+   +   F      
Sbjct: 1967 IDMGKELLARSHYAAEE--ISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGM 2024

Query: 1675 FDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1718
             + WL   E L+ S + G  +  V +L+K+H+  +    A E+R
Sbjct: 2025 AEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEER 2068



 Score =  437 bits (1123), Expect = e-122
 Identities = 421/1888 (22%), Positives = 807/1888 (42%), Gaps = 121/1888 (6%)

Query: 216  IQEQHPEEELIKTKQDEVNAAWQRLKGLALQ--RQGKLFGAAE-----VQRFNRDVDETI 268
            +    P+E+ I T        + ++K LA++  R GK+   A      V+++     E +
Sbjct: 259  VNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELL 318

Query: 269  SWIKEKEQLMASDDFGRDLASVQALLRKHEG---------------LERDLAALEDKVKA 313
             WI++    +        L+ VQ  L+                   LE  L  ++ K++A
Sbjct: 319  QWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRA 378

Query: 314  LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY----RLQRFLAD 369
               +    ++   +S         ++   WE++     ER   L        +L++  A 
Sbjct: 379  NNQKVYTPREGRLIS---------DINKAWERLEKAEHERELALRTELIRQEKLEQLAAR 429

Query: 370  FRDLTS----WVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
            F    +    W++E + L++ D    ++A  EA + +H+  + +I A+    ++ D    
Sbjct: 430  FDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAA 489

Query: 426  ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
             L A  ++    +  +   ++     L ++   RR++    ++LQ  ++D   + +WM +
Sbjct: 490  ELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEE 549

Query: 486  QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ-NNHYAMED- 543
             +  L ++DLG  L  VE LL+ HE  E  ++ Q E++ A+   A +       Y   D 
Sbjct: 550  MKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDP 609

Query: 544  --VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT-ATDEA 600
              V+ R   L     AL E A  RRA+L +S  L +F  +  E ++WV E+    A+ + 
Sbjct: 610  QLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADT 669

Query: 601  YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
             +D +     + KH A   E+S     +    + GQ+L+   H    + +AR  E+ + W
Sbjct: 670  GRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW 729

Query: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
            ++L    E +  +L +A    QF  +  D+E WL +    ++S + G D  + Q L ++H
Sbjct: 730  ERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQH 789

Query: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
              LE ++ +H+  +D +  QA           E ++ +   L   YE L+     R + L
Sbjct: 790  RALEEEIRSHRPTLDALREQAAALPPTLSRTPE-VQGRVPTLERHYEELQARAGERARAL 848

Query: 781  ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
              +L L  +  +      W+ EKE         + L  ++ + ++ + L+ E+     +I
Sbjct: 849  EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908

Query: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
             AV      +++      + +     +LN +W+  +  A  ++  L  +L  Q Y  +  
Sbjct: 909  TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECT 968

Query: 901  EAESWMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-- 957
            E ++WMREK  ++ ST   G D     AL +K      DL A  + +  L  +A +    
Sbjct: 969  ETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028

Query: 958  ---QQVAPT----DDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE-- 1008
               Q VA      + +TG E + A    +E+S  E    + D L  L+       + +  
Sbjct: 1029 HPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQ-DFLRSLDDFQAWLGRTQTA 1087

Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQ 1068
            V   +G       + L    +A R  +   Q   +  +   +  TR   +   + LR + 
Sbjct: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQR- 1146

Query: 1069 VEELYHSLLELG---EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQ 1125
            +E L     ELG   E R+G L ++       R+A + +  ++ +E  L+  E+   L+ 
Sbjct: 1147 LEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQA 1206

Query: 1126 VEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETD 1185
             +   KK +DF   + AN  R+  + +    L SEG             ++    R++ D
Sbjct: 1207 ADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEG------------NIHADKIREKAD 1254

Query: 1186 SKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADET 1245
            S                        +  R +  Q  A++    L    E Q F +D  E 
Sbjct: 1255 S------------------------IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHEL 1290

Query: 1246 KEWIEEKNQALNTDNYGHDLA-SVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP 1304
            K WI+EK   L   +  +D A ++    +KH+ F  +LAA  D ++ + +    L    P
Sbjct: 1291 KLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP 1348

Query: 1305 ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSS 1364
            E    + EK  +L++ W  L      +   L D++  + F      L SW+  ++  + S
Sbjct: 1349 ELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS 1408

Query: 1365 DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILD 1424
            D+  KD+T    LL++ Q    E+  R    +A  Q   + LA     + E+++    ++
Sbjct: 1409 DDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAI-QAQAKALAQEDQGAGEVERTSRAVE 1467

Query: 1425 QERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALI 1484
            ++   L +   +R   L    E   FHRD E    W+  R    ++ + G  L SV+ L+
Sbjct: 1468 EKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLM 1527

Query: 1485 KKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKR 1544
            KK++   K I   E +IA L+   ++  A G  A G   +   E+ + W+RL  ++  + 
Sbjct: 1528 KKNQTLQKEIQGHEPRIADLR---ERQRALGAAAAGPELA---ELQEMWKRLGHELELRG 1581

Query: 1545 SKLGESQTLQQFSRDVDEIEAWISEK-LQTASDESYKDPTNIQLSKLLSKHQKHQAFEAE 1603
             +L ++   QQF RD  E EAW+ E+ L     E  KD  + Q     ++ +KHQ  E  
Sbjct: 1582 KRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQ-----AEVKKHQVLEQA 1636

Query: 1604 LHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
            L   A  I  +      +I+      +   +  R A +   +  L + + E+ ++L+E  
Sbjct: 1637 LADYAQTIHQLAASSQDMIDHEHPESTR--ISIRQAQVDKLYAGLKELAGERRERLQEHL 1694

Query: 1664 KQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISA-HEDRLKDL 1722
            +       + D + W+ E E + AS + G+D   V  L  K +    D S   ++R+   
Sbjct: 1695 RLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSA 1754

Query: 1723 NSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEE 1782
            N+ A+ L+       + V + +D++N  +  +  +  +R   L  ++ L +F        
Sbjct: 1755 NALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQAL 1814

Query: 1783 SWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIG 1842
            + ++ K+  +  +  GRDL   + L+++H   E ++ A  P +Q V D G +L       
Sbjct: 1815 ARVQHKQQQL-PDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873

Query: 1843 K-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASE 1901
            K EEI + +    E W +L+  +AAR Q L ++ +  +F   V E   W++E    + ++
Sbjct: 1874 KAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQ 1933

Query: 1902 DYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNG 1961
            +    +++   ++K  +  + +     DR +     G++L+ ++++  E IS K+  L  
Sbjct: 1934 ERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQA 1993

Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
            +  +  +   ++   L      L F   A + E+W+  +E  +++ + G  +  V++L+ 
Sbjct: 1994 RRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIK 2053

Query: 2022 KQETFDAGLQAFQQE--GIANITALKDQ 2047
            + E F     A+++    +  +TAL+++
Sbjct: 2054 RHEAFQKSAVAWEERFCALEKLTALEER 2081



 Score =  318 bits (814), Expect = 5e-86
 Identities = 277/1205 (22%), Positives = 530/1205 (43%), Gaps = 43/1205 (3%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72
            I   ++Q+  R+ +F+ L+  ++  L  +   Q +  +  E + W++EK ++        
Sbjct: 929  IVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLG 988

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
             D   +    +K    E +++A +  + +L    N + +     +  I  RL E+   WE
Sbjct: 989  NDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWE 1048

Query: 133  LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFE 192
             L   MR +   L +A++L  +LR  +D   W+   +  V SEE    L   E L  +  
Sbjct: 1049 DLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHA 1108

Query: 193  EFQTDMAAHEERVNEVNQFAAKLIQEQ-HPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
              + ++   +   + +     ++ ++Q  P+   ++ + + +   W+ L  +   RQG+L
Sbjct: 1109 ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168

Query: 252  FGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKV 311
              A   Q F RD  +    +  +E +++  +    L +  A ++K E     + A  +++
Sbjct: 1169 AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERI 1228

Query: 312  KALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFR 371
              L     +L     + A +I+ K + +    ++ +  A +   RL D+   Q FL D  
Sbjct: 1229 HGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCH 1288

Query: 372  DLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAG 431
            +L  W+ E K L   D    +         +HQ    E+ A++D     D+ G+ L    
Sbjct: 1289 ELKLWIDE-KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEK 1347

Query: 432  HYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLL 491
                  V EKL  L      L    + + +        +LF +    +++W+   +A L 
Sbjct: 1348 PELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLH 1407

Query: 492  NEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDAL 551
            ++D G  L SV  LLKK +  E  ++ +E+++ A+   A  L Q +  A E   T R A+
Sbjct: 1408 SDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSR-AV 1466

Query: 552  LSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSNLQGK 610
              +  AL +    R  +L  S    QF RD ++   WV E++  A+  E  KD  ++Q  
Sbjct: 1467 EEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526

Query: 611  VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELK 670
            ++K+Q  + E+  ++ RI  L +  + L              + E+  +WK+L    EL+
Sbjct: 1527 MKKNQTLQKEIQGHEPRIADLRERQRAL------GAAAAGPELAELQEMWKRLGHELELR 1580

Query: 671  GIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAH 730
            G +L +A + QQF R+  + E W+ E E H+   +  KD  + Q   KKH +LE  +A +
Sbjct: 1581 GKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADY 1640

Query: 731  QDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLF 790
               I  +   ++   D  H ++  I  +Q  +   Y  LKE    R+++L + LRL QL 
Sbjct: 1641 AQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLR 1700

Query: 791  RDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIA--GHEPRIKAVTQKGN 848
            R+++D E WI+E+E +AAS   G+D   V  L  K +    + +  G E R+ +     N
Sbjct: 1701 RELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQE-RVDSANALAN 1759

Query: 849  AMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
             ++  GH A   V      LN+ W  L      R Q L  + + Q++   A +A + ++ 
Sbjct: 1760 GLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQH 1819

Query: 909  KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD-DET 967
            K+  +     G+D ++AEAL ++H A   D+ A    +Q +++     ++  A    +E 
Sbjct: 1820 KQQQLPDGT-GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEI 1878

Query: 968  GKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVK---KL 1024
            G+ +      + +        ++     LL++T+K  +   V +   ++    ++   + 
Sbjct: 1879 GRHMQAVAEAWAQLQGSSAARRQ----LLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQE 1934

Query: 1025 DPAQSASRENLLEEQ----GSIALRQEQIDNQTRITKE--------AGSVSLRMKQVEEL 1072
             P   +S + +++ Q      I  R ++  +   + KE        A  +S ++ Q++  
Sbjct: 1935 RPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQAR 1994

Query: 1073 YHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKK 1132
                 E  +++   L+   +  +  R+A   + W+  +E  + S E+G  +++VE L K+
Sbjct: 1995 RQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKR 2054

Query: 1133 FDDFQKDLKANESRLKDINKVA--EDLESEGLMAEEVQAVQQQ-----EVYGMMPRDETD 1185
             + FQK   A E R   + K+   E+ E E     E +  ++Q         + P D   
Sbjct: 2055 HEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPGDLVG 2114

Query: 1186 SKTAS 1190
             +TAS
Sbjct: 2115 GQTAS 2119



 Score =  277 bits (708), Expect = 1e-73
 Identities = 296/1437 (20%), Positives = 593/1437 (41%), Gaps = 133/1437 (9%)

Query: 1054 RITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAA 1113
            R+  +      R+++ E      L     R+  LE+   +F   R+A   + W++E +  
Sbjct: 390  RLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFD--RKAAMRETWLSENQRL 447

Query: 1114 LTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
            ++ +  G +L  VE   +K +  + D+ A   R++ ++ VA +L +E     +  A +Q 
Sbjct: 448  VSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQH 507

Query: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
             V                   ARL                 W  L+Q+   R + L    
Sbjct: 508  NV-------------------ARL-----------------WDFLRQMVAARRERLLLNL 531

Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
            E+Q+  +D     +W+EE    L + + G  LA V+ L + HE  E D+A   ++V ++ 
Sbjct: 532  ELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVS 591

Query: 1294 ETAERLI----QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFR 1349
             +A R      +  P   + + E+  +L Q++ +L + A  R+A+L +S  L RFL +  
Sbjct: 592  ASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVG 651

Query: 1350 DLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHG 1409
            +  +W+   + L++S +  +D+TGA  LL +H   R E+  R G  +   + GQQL+A G
Sbjct: 652  EAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEG 711

Query: 1410 HYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLN 1469
            H  + +   +   L  +   LE    +R   L Q   L  F  D    E W+      ++
Sbjct: 712  HPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVS 771

Query: 1470 TEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEV 1529
            + + G    S +AL ++H   ++ I      + AL+  A  L         ++  R   +
Sbjct: 772  SPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTP-EVQGRVPTL 830

Query: 1530 LDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSK 1589
               +  L+A+  E+   L  +  L     +      W+ EK Q  +  +  +    +L  
Sbjct: 831  ERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPE----RLED 886

Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLV 1649
            L    Q+ +  E E++  A +I  V D+   L++  A    +D +      L  +WQ   
Sbjct: 887  LEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK--ANPPGKDRIVNTQEQLNHRWQQFR 944

Query: 1650 QKSAEKSQKLKEANKQQNFNTGIKDFDFWLSE-VEALLASEDYGKDLASVNNLLKKHQLL 1708
            + +  K   L  A   QN++    +   W+ E  + + +++  G DLA V  L +K    
Sbjct: 945  RLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGT 1004

Query: 1709 EADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNES 1768
            E D+ A   R+ +L  +A++L          +  +   +   ++ +++    R   L E+
Sbjct: 1005 ERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEA 1064

Query: 1769 HRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGV 1828
             RL  F R +DD ++W+   +  V SE+    L   + L  +H  L  E+   +     +
Sbjct: 1065 RRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL 1124

Query: 1829 LDTGKKLSDDNTIGK-EEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
               G++++ D    +   ++QRL      W+EL ++  +R  RL ++  +Q F+ +  + 
Sbjct: 1125 RALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA 1184

Query: 1888 EAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH 1947
            E  ++ +  +++  +   TL A    +KK E F +    + +R++ +   G+ L+ + N 
Sbjct: 1185 EGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNI 1244

Query: 1948 HEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTD 2007
            H + I  K   +  +    + AA Q   +L +N     F      ++ WI EK  + +  
Sbjct: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDV 1304

Query: 2008 DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLM 2067
             Y  +  ++ T   K + F A L A  ++ +  +     +L   K      +  +   L 
Sbjct: 1305 SYD-EARNLHTKWQKHQAFMAELAA-NKDWLDKVDKEGRELTLEKPELKALVSEKLRDLH 1362

Query: 2068 KRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDL------TD 2121
            +RW +L   + A+ + L +A     + E     FA+   A  SW E+ +  L       D
Sbjct: 1363 RRWDELETTTQAKARSLFDA----NRAE----LFAQSCCALESWLESLQAQLHSDDYGKD 1414

Query: 2122 PVRCNSLEEIKALREAHDAFR-SSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEAL 2180
                N L + + + E   A R   + + QA    LA+ D+               T  A+
Sbjct: 1415 LTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVE--------RTSRAV 1466

Query: 2181 EETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTY-------- 2232
            EE +R L + ++ER   LQ  + + + +  +  E          W+ E            
Sbjct: 1467 EEKFRALCQPMRERCRRLQASREQHQFHRDVEDEIL--------WVTERLPMASSMEHGK 1518

Query: 2233 -LLDGSCMVEESGTLESQLEATKRKHQEIR---------AMRSQLKKIEDL--------- 2273
             L     +++++ TL+ +++  + +  ++R         A   +L +++++         
Sbjct: 1519 DLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELE 1578

Query: 2274 --GAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQAR---NTTGVTEE 2328
              G  +E+AL     Y + +    A+ W    +L M  Q   + ++ A+       V E+
Sbjct: 1579 LRGKRLEDALRAQQFYRDAAE---AEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQ 1635

Query: 2329 ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRD 2388
            AL +++             ++H+  +S   S       + + + D  +  + +     R+
Sbjct: 1636 ALADYAQTIHQLAASSQDMIDHEHPESTRIS-------IRQAQVDKLYAGLKELAGERRE 1688

Query: 2389 GHVSLQEYMAF-MISRETENVK---SSEEIESAFRALSSEGKPYVTKEELYQNLTRE 2441
                LQE++    + RE ++++      E+ +A   L  + +      + ++  +R+
Sbjct: 1689 ---RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRD 1742



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 62/225 (27%), Positives = 113/225 (50%), Gaps = 6/225 (2%)

Query: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY-RFQFFQRDAEELEKWIQE-KLQIA 67
            + AE+I    Q V + + + +  S  RRQ L D+  +F+FF+    EL  W+ E  LQ+ 
Sbjct: 1873 DKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA-VRELMLWMDEVNLQMD 1931

Query: 68   SDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMEL 127
            + E  +D ++    ++  Q  +AE++A +       + G  +++  H+A+E I  +L +L
Sbjct: 1932 AQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQL 1991

Query: 128  HRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVL 187
              + +   EK +EK   L    +++ + R+      W+  +E +V S ELG  ++ VE L
Sbjct: 1992 QARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESL 2051

Query: 188  QKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDE 232
             K+ E FQ    A EER   + +  A    E+  +E   K +++E
Sbjct: 2052 IKRHEAFQKSAVAWEERFCALEKLTA---LEEREKERKRKREEEE 2093



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 60/253 (23%), Positives = 105/253 (41%), Gaps = 19/253 (7%)

Query: 2078 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2137
            A   K++ +   H  + E L   +   AS    W E     L D    NSL  ++   ++
Sbjct: 287  AVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQS 346

Query: 2138 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASNPYTWFTMEA-----LEETWRNLQKII 2191
             +++R+     +  +   L  L   I+S   A+N   +   E      + + W  L+K  
Sbjct: 347  FNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAE 406

Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2251
             EREL L+ E  RQE+ ++L   F + A     W+ E +  +       +  G   + +E
Sbjct: 407  HERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-----DNFGLELAAVE 461

Query: 2252 ATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQL-- 2305
            A  RKH+    +I A   +++ ++ + A +      D K        +A+ WD L Q+  
Sbjct: 462  AAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521

Query: 2306 --GMRMQHNLEQQ 2316
                R+  NLE Q
Sbjct: 522  ARRERLLLNLELQ 534


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
            sapiens]
          Length = 2564

 Score =  433 bits (1114), Expect = e-121
 Identities = 356/1412 (25%), Positives = 621/1412 (43%), Gaps = 102/1412 (7%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73
            + ER      R+ R +E +  R ++L+++     F  D + L  W+++  ++A+  ++  
Sbjct: 744  LAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGH 803

Query: 74   DPTNLQGKLQKHQAFEAEVQANSGAIVKLDE----------TGNLMISEGHFASETIRTR 123
            D  + +   ++H+A   EV+A+ G +  L             G L+++        ++ R
Sbjct: 804  DEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVA--------LQVR 855

Query: 124  LMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEH 183
            ++E  + +  + E    +   L  A  + +   E      WI +KE  + S  +   L+ 
Sbjct: 856  VVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDD 915

Query: 184  VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGL 243
            VEV+Q +FE    +M +   RV +VN    +L++  HP  + +++ QD +N+ W R+  L
Sbjct: 916  VEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVEL 975

Query: 244  ALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERD 303
              QR+ ++     V+    +V E  + ++EK + + S        +  AL  +  GLE  
Sbjct: 976  VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAP-----RAGGALQWRLSGLEAA 1030

Query: 304  LAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
            L ALE +  AL  EA  L +  P  A ++    EEL   W  + + A      +  + RL
Sbjct: 1031 LQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRL 1090

Query: 364  QRFLADFRDLTSWVTEMKALINADE--LASDVAGAEALLDRHQEHKGEIDAHEDSFKSAD 421
            QRFL D      W+   +      E  L + +  A+ALL RH   K E+D  E+ +    
Sbjct: 1091 QRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIV 1150

Query: 422  ESGQALLAAGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQ 478
             + +ALLAA          + E L  L      LL LWE RR+   Q    QLF RD  Q
Sbjct: 1151 AASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQ 1210

Query: 479  VDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH 538
                +  QE  L   +L  +++SVE  LK+H DF  ++   ++K+    + A  L++  +
Sbjct: 1211 ALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGN 1270

Query: 539  YAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD 598
               E        LL +      RA +   +L D   LQ F RD  EL  W++EKM  A D
Sbjct: 1271 IYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARD 1330

Query: 599  EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVIS 658
               +D   L  +  +HQAF AEL+ N+  ++ +E+ GQ+L+         V  ++ E+  
Sbjct: 1331 GTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390

Query: 659  LWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQK 718
             W +L   T+ K  +L EA++  Q  ++  +++  L  +E  L   D G DL  V +  K
Sbjct: 1391 CWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLK 1450

Query: 719  KHALLEADVAAHQDRIDGITIQ--ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVAR 776
            K   +E+ V      +  +  Q  A   + A     E + ++Q A+  R   L EP+  R
Sbjct: 1451 KLQSMESQVEEWYREVGELQAQTAALPLEPASK---ELVGERQNAVGERLVRLLEPLQER 1507

Query: 777  KQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGH 836
            ++ L  S  L Q+  D++DE  W++E+ P+A  T RG  L  VQ  +KK+Q L+ EI  H
Sbjct: 1508 RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 1567

Query: 837  EPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYF 896
             PR++ V ++  A+       AE V+  L +L   W  L+  A +R+Q L+ + Q +QY+
Sbjct: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627

Query: 897  ADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC 956
             D  E E+W+ E+E ++ S D GKDE S   LLKKH  L   +  Y  SI  L  Q ++ 
Sbjct: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687

Query: 957  RQQVAPTDDETGK------ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVN 1010
             +   P  ++  +       L +AL +  E+  R V +++   L  L+         +V+
Sbjct: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLYQLSR--------QVS 1737

Query: 1011 DRQGFVPAAYVKKLDP--AQSASRENLLEEQGS-------------IALRQEQIDNQTRI 1055
            + + ++    V    P   Q     ++L+E+ S             +A   + +D     
Sbjct: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797

Query: 1056 TKEAGSVSLRMKQ-VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
               A +     K  + E +  LLEL   R  +L  S +    F +A ELQ  I EK   L
Sbjct: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857

Query: 1115 TSEEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
                   +       +Q+    F+ DL+   S+++ + + A  L +     E  +A+  +
Sbjct: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTV-YAGEHAEAIASR 1916

Query: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
            E                                  +E+ + W+ L    E+    + S  
Sbjct: 1917 E----------------------------------QEVLQGWKELLSACEDARLHVSSTA 1942

Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
            +  RFH    +   W++     +   +   D++SV+ L   H+G + +L A   ++ +  
Sbjct: 1943 DALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQ 2002

Query: 1294 ETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMS 1353
            E    L+ +    A+++Q +  +L      + ++ D+    L    ++ +F  +     +
Sbjct: 2003 ELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA 2062

Query: 1354 WINGIRGLVSSDELAKDVTGAEALLERHQEHR 1385
            W+     L+ S EL   V   E L+ RH+  R
Sbjct: 2063 WLTAQEPLLQSRELGSSVDEVEQLIRRHEAFR 2094



 Score =  413 bits (1062), Expect = e-115
 Identities = 421/1813 (23%), Positives = 768/1813 (42%), Gaps = 177/1813 (9%)

Query: 584  ELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNH 643
            EL +W++  +   +++ + +  +L G  Q+ QAF A  +  +  +   EK   +++  + 
Sbjct: 320  ELLAWIHRTVGLISNQKFAN--SLSGVQQQLQAFTAYCTLEKP-VKFQEKGNLEVLLFSI 376

Query: 644  YAKDEVAAR----------MNEVISLWKKLLEATELKGIKLR-EANQQ-------QQFNR 685
             +K     R          + ++   W +L +A   +   LR E  +Q       Q+F+ 
Sbjct: 377  QSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDH 436

Query: 686  NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745
             V   E WL E +  ++ D++G +L  V+   KKH  +EAD+AA+++R+ G+   A+   
Sbjct: 437  KVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALA 496

Query: 746  DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
              G++D   +  ++++++ ++  L   + AR+ +L  +L LQ++F+++     W+ E + 
Sbjct: 497  AEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQA 556

Query: 806  IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
               S   G+ L+   +LL+KH  L+ +IA    R++A+        +   +   D +   
Sbjct: 557  QLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVIC 616

Query: 866  HELNQKWEAL---KAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIV--------- 913
            + +N     L   + +A++RR +LE S        +  EAESW R+KE ++         
Sbjct: 617  NRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAA 676

Query: 914  ------GSTDYGKDEDSAEALLKKHEALMS-----------------DLSAYGSSIQ--- 947
                  G+     D  S   LL +H+ L                   +L A G ++    
Sbjct: 677  GAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGA 736

Query: 948  ------ALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTN 1001
                   L E+A S R++    ++   +       + + +  R +     D+  LL+   
Sbjct: 737  DTVHLVGLAERAASARRRWQRLEEAAARR------ERRLQEARALHQFGADLDGLLDWL- 789

Query: 1002 KDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGS 1061
            +D +++      G   A+  ++L     A    +   +G ++  + Q+      +     
Sbjct: 790  RDAYRLAAAGDFGHDEASS-RRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPL 848

Query: 1062 V---SLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEE 1118
            V    +R+ + E+L+  + E+   R+  L  +   + +F E +  + WI EKE  L S  
Sbjct: 849  VVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMR 908

Query: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGL-MAEEVQAVQQQEVYG 1177
            V   L+ VEV+Q +F+   +++ +   R+ D+N   ++L   G   ++EV++ Q      
Sbjct: 909  VPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDH---- 964

Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQR 1237
                                             LN RW  + +L E+R + + +   V+ 
Sbjct: 965  ---------------------------------LNSRWNRIVELVEQRKEEMSAVLLVEN 991

Query: 1238 FHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297
               +  E +  + EK +A+ +           ALQ +  G E  L AL  +  +L E A 
Sbjct: 992  HVLEVAEVRAQVREKRRAVESAPRAGG-----ALQWRLSGLEAALQALEPRQAALLEEAA 1046

Query: 1298 RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWING 1357
             L +  P  A  L +   EL   W +L   A      +  +  LQRFL D    + W+  
Sbjct: 1047 LLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVR 1106

Query: 1358 IRGLVSSDE--LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA-HGHYASP 1414
             +      E  L   +  A+ALL RH   + E+D R   +       + LLA  G    P
Sbjct: 1107 AQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGP 1166

Query: 1415 --EIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED 1472
               + + L  L+     L   W  RR  L Q    QLF RD  QA   +  +E  L+  +
Sbjct: 1167 GLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAE 1226

Query: 1473 KGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDR 1532
               +++SVE  +K+H DF   + + ++K+      A+ L+  G+            +L++
Sbjct: 1227 LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEK 1286

Query: 1533 WRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLS 1592
             +  + +  +   KL +   LQ F RD  E++ WI EK+  A D + +D       KL  
Sbjct: 1287 NQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDN-----HKLHK 1341

Query: 1593 KHQKHQAFEAELHANADRIRGVIDMGNSLI-ERGACAGSEDAVKARLAALADQWQFLVQK 1651
            +  +HQAF AEL  N + +  +   G  L+ E+   A S   V+ +L  +   W  L   
Sbjct: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS---VRKKLGEIRQCWAELEST 1398

Query: 1652 SAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEAD 1711
            +  K+++L EA+K         + D  L  +E+ L   D G DLA+VN+ LKK Q +E+ 
Sbjct: 1399 TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQ 1458

Query: 1712 ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRL 1771
            +      + +L +Q  +L    A     V ++++ +  R  ++      RR  L  S  L
Sbjct: 1459 VEEWYREVGELQAQTAALPLEPA-SKELVGERQNAVGERLVRLLEPLQERRRLLLASKEL 1517

Query: 1772 HQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDT 1831
            HQ   D+DDE +W++E+  L    + G  L  VQ   KK++ L  E+ AH P ++ VL+ 
Sbjct: 1518 HQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 1577

Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWI 1891
               L+   +   E +++ L Q    W  L++ A  R Q L+ + + +Q+  +V E EAW+
Sbjct: 1578 AGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637

Query: 1892 NEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEEN 1951
             E+  L+ SED G    +   LLKKH   E     +++ +  +    + L++  +   E 
Sbjct: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697

Query: 1952 ISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGR 2011
            IS +   ++     L++   +R+  L++     Q + +   +E WI EKE    + + G+
Sbjct: 1698 ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQ 1757

Query: 2012 DLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWS 2071
            D   V  L  K   F +      +E +A +  + D+L+   H  +  +      L + W+
Sbjct: 1758 DFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWA 1817

Query: 2072 QLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEI 2131
            +LL     R  +LL A     K       F   A       E          R   L   
Sbjct: 1818 ELLELMGTR-AQLLAASRELHK-------FFSDARELQGQIEEKRR------RLPRLTTP 1863

Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
               R +  + + +L + + D   L    RQ++    A+   T +  E  E      Q++ 
Sbjct: 1864 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ--EGAAQLRTVYAGEHAEAIASREQEV- 1920

Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLE---- 2247
                L+  KE     E+ +L       A  FH  +++  ++ +DG  +  + G  +    
Sbjct: 1921 ----LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSW-MDG--IASQIGAADKPRD 1973

Query: 2248 -SQLEATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQL 2302
             S +E     HQ    E+ A   +L   ++LG +     +L NK      +       QL
Sbjct: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRS-----LLLNKSAMADEIQA-----QL 2023

Query: 2303 DQLGMRMQHNLEQ 2315
            D+LG R +   E+
Sbjct: 2024 DKLGTRKEEVSEK 2036



 Score =  370 bits (949), Expect = e-101
 Identities = 402/1874 (21%), Positives = 768/1874 (40%), Gaps = 152/1874 (8%)

Query: 363  LQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEID 411
            ++R+     +L +W+     LI+  + A+ ++G +  L               + KG ++
Sbjct: 311  IERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLE 370

Query: 412  AHEDSFKSADESGQALL-----AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQC 466
                S +S   +    L       G +  D+   +L     ER A L    +R+++ E  
Sbjct: 371  VLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLE-- 428

Query: 467  MDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL 526
            +  Q F       ++W+++ +  +  ++ G  L +VEA +KKHE  E  ++A EE++  +
Sbjct: 429  LLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGV 488

Query: 527  DEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELK 586
             E A  L    +Y +  VA +RD++L +   L      RR +L  +  LQ+ F++   + 
Sbjct: 489  AELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMV 548

Query: 587  SWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA 645
             W+ E + +  + E  +        +QKH   E +++A   R++AL  A  +   +  Y 
Sbjct: 549  DWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQ 608

Query: 646  KDE---VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLA 702
              +   +  R+N V     +L E    +  +L  +       + +E+ E W  + E  L 
Sbjct: 609  PCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLE 668

Query: 703  SDDYG---------------KDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
            +   G                DL++   L  +H +L+ ++   +  +        +   A
Sbjct: 669  AAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAA 728

Query: 748  GH--------FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETW 799
            G              + ++  +   R++ L+E    R+++L ++  L Q   D++    W
Sbjct: 729  GGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDW 788

Query: 800  IREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK----GNAMVEEGH 855
            +R+   +AA+ + G D    + L ++H+AL  E+  H   +  + ++    G A      
Sbjct: 789  LRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPL 848

Query: 856  FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGS 915
              A  ++ ++ E  Q +  +   A+ RRQ L D+L   + F + +  E W+ EKE  + S
Sbjct: 849  VVA--LQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLS 906

Query: 916  TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK------ 969
                   D  E +  + E+L  ++++    +  +    Q   +   P+ DE         
Sbjct: 907  MRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLN 966

Query: 970  ---ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDP 1026
                 ++ L + +++    V + +  +L +         + +V +++  V +A      P
Sbjct: 967  SRWNRIVELVEQRKEEMSAVLLVENHVLEVAEV------RAQVREKRRAVESA------P 1014

Query: 1027 AQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMK-QVEELYHSLLELGEKRKG 1085
                + +  L   G  A  Q     Q  + +EA  ++ R   Q   L+    ELG +   
Sbjct: 1015 RAGGALQWRLS--GLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGA 1072

Query: 1086 MLEKSCKKFMLFREANELQQWINEKEAALT----SEEVGADLEQVEVLQKKFDDFQKDLK 1141
            +   +         A  LQ+++++ +A L     ++E     E    L    ++    L 
Sbjct: 1073 LASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGP--LPNSLEEADALLA 1130

Query: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201
             + +  +++++  ED       +E + A    E+   +  DE        W         
Sbjct: 1131 RHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDE--------W--------- 1173

Query: 1202 VATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNY 1261
                  +  L   W  L  L E R + L  AH  Q F RD  +    +  +  AL+    
Sbjct: 1174 ------LPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAEL 1227

Query: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAW 1321
               + SV+   ++H  F   +     K+    + AE L++      E  QE  T L +  
Sbjct: 1228 PGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKN 1287

Query: 1322 SSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERH 1381
                 RA Q   KL D  +LQ FL D  +L  WI+  + L++ D   +D         RH
Sbjct: 1288 QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHE-KMLMARDGTREDNHKLHKRWLRH 1346

Query: 1382 QEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMML 1441
            Q    E+       +  E+ GQQL+      +  +++KL  + Q  A+LE     +   L
Sbjct: 1347 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 1406

Query: 1442 DQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKI 1501
             +  +     +   + +  +   E+ L   D G  L +V + +KK +  +  +     ++
Sbjct: 1407 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 1466

Query: 1502 AALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVD 1561
              LQA    L      +K  +  R+N V +R  RL   + E+R  L  S+ L Q + D+D
Sbjct: 1467 GELQAQTAAL-PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLD 1525

Query: 1562 EIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSL 1621
            +  AW+ E+L  A      +     L  +    +K+Q    E+ A+  R+  V++   +L
Sbjct: 1526 DELAWVQERLPLAMQTERGNG----LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 1581

Query: 1622 IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSE 1681
                +     +AV+  L  L   W  L + +  + Q L  A + + +   + + + WL E
Sbjct: 1582 ASLRS--PEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 1639

Query: 1682 VEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVK 1741
             E L+ SED GKD  S   LLKKH  LE  +  +E+ +  L+ Q  +L+     D+ Q+ 
Sbjct: 1640 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQIS 1699

Query: 1742 DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDL 1801
             ++  ++  +  +K +   RR  L + + L+Q  R + + E WI EK+++ GS + G+D 
Sbjct: 1700 RRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDF 1759

Query: 1802 TGVQNLRKKHKRLEAE--------LAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQF 1853
              V  L++K     +E        LAA    +  +++ G   +      K+ +       
Sbjct: 1760 EHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN------ 1813

Query: 1854 VEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT----LVASEDYGDTLAA 1909
             E W EL +L   R Q L  S E  +F ++  E +  I EK      L    +   + ++
Sbjct: 1814 -EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 1872

Query: 1910 IQGLLKKHEAFETDFTVHKDRVNDVCTNGQDL--IKKNNHHEENISSKMKGLNGKVSDLE 1967
            +Q  L+   AFE D  +   +V  +      L  +    H E   S + + L G   +L 
Sbjct: 1873 MQRTLR---AFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW-KELL 1928

Query: 1968 KAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFD 2027
             A    +  +   +  L+F+ +   + SW+    + +   D  RD+SSV+ L+   +   
Sbjct: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988

Query: 2028 AGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEA 2087
              L+A   E +     L   LL  K   +  I+A+           L     RK+++ E 
Sbjct: 1989 TELEARVPE-LTTCQELGRSLLLNKSAMADEIQAQ-----------LDKLGTRKEEVSEK 2036

Query: 2088 -QSHFRKVEDLFLT--FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSS 2144
               H+  ++ +     FA++A   ++W    E  L      +S++E++ L   H+AFR +
Sbjct: 2037 WDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKA 2096

Query: 2145 LSSAQADFNQLAEL 2158
             ++ +  F+ L  L
Sbjct: 2097 AAAWEERFSSLRRL 2110



 Score =  348 bits (894), Expect = 3e-95
 Identities = 405/1900 (21%), Positives = 791/1900 (41%), Gaps = 134/1900 (7%)

Query: 1    MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLR----------RQKLEDSYRFQFFQ 50
            +DP  V +   A D +     V+  YH F ++  L            Q LE     + ++
Sbjct: 258  LDPEDVNM--EAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVGKIIERYE 315

Query: 51   RDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI 110
              A EL  WI   + + S++ + +  +L G  Q+ QAF A         VK  E GNL +
Sbjct: 316  ELAAELLAWIHRTVGLISNQKFAN--SLSGVQQQLQAFTAYCTLEKP--VKFQEKGNLEV 371

Query: 111  SEGHFASE--TIRTRLM---------ELHRQWELL--LEKMREKGIK--LLQAQKLVQYL 155
                  S+      RL          ++ + W  L   E  RE  ++  L++ +KL    
Sbjct: 372  LLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLA 431

Query: 156  RECEDVM----DWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
            +  +  +     W+N+ + +V+ +  G +L  VE   KK E  + D+AA+EERV  V + 
Sbjct: 432  QRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAEL 491

Query: 212  AAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWI 271
            A  L  E + +   +  ++D V   W  L GL   R+ +L     +Q+  +++   + W+
Sbjct: 492  AQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWM 551

Query: 272  KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEA---DRLQQSHPLS 328
            +E +  + S + G+ L     LL+KH  LE D+AA  ++V+AL A A    +LQ   P  
Sbjct: 552  EEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCD 611

Query: 329  ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINA-- 386
               I  +   +     +++  AA R A L  S  L   L +  +  SW  + + L+ A  
Sbjct: 612  PQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAG 671

Query: 387  -------------DELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHY 433
                            A D++    LL +H+  +GE+       + A   G+ L+AAG  
Sbjct: 672  GGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGA 731

Query: 434  ---ASDEVREKLTVLSEERAALLELWE-------LRRQQYEQCMDLQLFYRDTEQVDNWM 483
                +D V   L  L+E  A+    W+        R ++ ++   L  F  D + + +W+
Sbjct: 732  VGPGADTVH--LVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWL 789

Query: 484  SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
                      D G    S   L ++H      + A    ++ L      L   +      
Sbjct: 790  RDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLV 849

Query: 544  VATRRDALLSRR--NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY 601
            VA +   + + +    + E A  RR  L D+  + + F +    + W+ EK +       
Sbjct: 850  VALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRV 909

Query: 602  KDPSNLQGKVQ-KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
             D  +    VQ + ++ + E+++   R+  +    Q+L++  H + DEV +  + + S W
Sbjct: 910  PDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRW 969

Query: 661  KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
             +++E  E +  ++      +     V ++   + E    + S            LQ + 
Sbjct: 970  NRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGA-----LQWRL 1024

Query: 721  ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
            + LEA + A + R   +  +A    +     A  + +  E L A + AL     A  + +
Sbjct: 1025 SGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAV 1084

Query: 781  ADSLRLQQLFRDVEDEETW-IREKEPIAASTNRG---KDLIGVQNLLKKHQALQAEIAGH 836
            A + RLQ+   D++    W +R +E  AA  + G     L     LL +H AL+ E+   
Sbjct: 1085 AAAGRLQRFLHDLDAFLDWLVRAQE--AAGGSEGPLPNSLEEADALLARHAALKEEVDQR 1142

Query: 837  EPRIKAVTQKGNAMV-----EEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891
            E     +     A++     E G   A D    L  L   W  L      RR+ L  +  
Sbjct: 1143 EEDYARIVAASEALLAADGAELGPGLALD--EWLPHLELGWHKLLGLWEARREALVQAHI 1200

Query: 892  AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
             Q +  D  +A   +R +E  +   +     +S E  LK+H   ++ +      +Q   +
Sbjct: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ 1260

Query: 952  QAQSCRQQVAPTDDETGKELVLALYDYQEKSPR--EVTMKKGDILTLLNSTNKDWWKVEV 1009
             A+   +Q     ++  + +   L   QE   R  +   K  D L L +         + 
Sbjct: 1261 AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLR------DC 1314

Query: 1010 NDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQV 1069
            ++  G++     +K+  A+  +RE+      +  L +  + +Q  + + A +    ++++
Sbjct: 1315 HELDGWIH----EKMLMARDGTRED------NHKLHKRWLRHQAFMAELAQNKEW-LEKI 1363

Query: 1070 EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEV 1128
            E     L++     K  L  S +K     +  E++Q W   +           +  + + 
Sbjct: 1364 EREGQQLMQ----EKPELAASVRK-----KLGEIRQCWAELESTTQAKARQLFEASKADQ 1414

Query: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
            L + F +  K L   ES+L+D++    DL +     +++Q+++ Q         E  ++T
Sbjct: 1415 LVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQT 1473

Query: 1189 AS-PWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKE 1247
            A+ P + A   +           + ER   L +  +ER +LL ++ E+ +   D D+   
Sbjct: 1474 AALPLEPASKEL----VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELA 1529

Query: 1248 WIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESA 1307
            W++E+         G+ L +VQ   +K++G  R++ A G ++  + E A  L       A
Sbjct: 1530 WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEA 1589

Query: 1308 EDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
            E ++    +L  AW+ L + A++R+  L  +  ++++  D  ++ +W+     L+ S++ 
Sbjct: 1590 EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 1649

Query: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQER 1427
             KD      LL++H +    ++    +     +  + LL  GH  S +I ++   +D+  
Sbjct: 1650 GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLY 1709

Query: 1428 ADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487
              L++   +RR+ L+Q   L    R   + E+W+A +E    + + G   + V  L +K 
Sbjct: 1710 VALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKF 1769

Query: 1488 EDFDKAINVQ-EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546
             +F     +   E++AA+    D+LI  GH A   ++  ++ + + W  L   M  +   
Sbjct: 1770 SEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL 1829

Query: 1547 LGESQTLQQFSRDVDEIEAWISEK---LQTASDESYKDPTNIQLSKLLSKHQKHQAFEAE 1603
            L  S+ L +F  D  E++  I EK   L   +      P+   + + L      +AFE +
Sbjct: 1830 LAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL------RAFEHD 1883

Query: 1604 LHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEKSQKLKEA 1662
            L     ++R + +    L  R   AG   +A+ +R   +   W+ L+    +    +   
Sbjct: 1884 LQLLVSQVRQLQEGAAQL--RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSST 1941

Query: 1663 NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1722
                 F++ ++D   W+  + + + + D  +D++SV  L+  HQ L+ ++ A    L   
Sbjct: 1942 ADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTC 2001

Query: 1723 NSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEE 1782
                 SL+ + +    +++ + D +  R +++          L +   +HQF ++    +
Sbjct: 2002 QELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVAD 2061

Query: 1783 SWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1822
            +W+  ++ L+ S + G  +  V+ L ++H+      AA E
Sbjct: 2062 AWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWE 2101



 Score =  276 bits (706), Expect = 2e-73
 Identities = 203/840 (24%), Positives = 389/840 (46%), Gaps = 15/840 (1%)

Query: 13   EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY 72
            E  QE   ++L++    +  +    QKL D    Q F RD  EL+ WI EK+ +A D   
Sbjct: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
            +D   L  +  +HQAF AE+  N   + K++  G  ++ E    + ++R +L E+ + W 
Sbjct: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393

Query: 133  LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFE 192
             L    + K  +L +A K  Q ++   ++   +   E+ +   + G DL  V    KK +
Sbjct: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 1453

Query: 193  EFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLF 252
              ++ +      V E+    A L  E    +EL+  +Q+ V     RL     +R+  L 
Sbjct: 1454 SMESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLL 1512

Query: 253  GAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
             + E+ +   D+D+ ++W++E+  L    + G  L +VQ  ++K++GL R++ A   +++
Sbjct: 1513 ASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLE 1572

Query: 313  ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372
             +   A  L       A  ++   E+L + W  +R  A  R   L+ +++++++  D  +
Sbjct: 1573 EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 1632

Query: 373  LTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
            + +W+ E + L+ +++   D      LL +H + +  ++ +E+S        +ALL  GH
Sbjct: 1633 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 1692

Query: 433  YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492
              S+++  + + +     AL EL E RR   EQ   L    R   ++++W++++E    +
Sbjct: 1693 PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 1752

Query: 493  EDLGDSLDSVEALLKKHEDFEKSLS-AQEEKITALDEFATKLIQNNHYAMEDVATRRDAL 551
             +LG   + V  L +K  +F      A  E++ A+++   +LI+  H A   +A  +D L
Sbjct: 1753 PELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGL 1812

Query: 552  LSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-----TATDEAYKDPSN 606
                  L E    R   LA S  L +FF D+ EL+  + EK +     T   E     S+
Sbjct: 1813 NEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 1872

Query: 607  LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA---KDEVAARMNEVISLWKKL 663
            +Q  +   +AFE +L    S++  L++   +L  V  YA    + +A+R  EV+  WK+L
Sbjct: 1873 MQRTL---RAFEHDLQLLVSQVRQLQEGAAQLRTV--YAGEHAEAIASREQEVLQGWKEL 1927

Query: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
            L A E   + +       +F+  V D+  W+  +   + + D  +D+++V+ L   H  L
Sbjct: 1928 LSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGL 1987

Query: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
            + ++ A    +       R         A+ I+ + + L  R E + E      + L   
Sbjct: 1988 KTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQM 2047

Query: 784  LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
            L + Q  ++    + W+  +EP+  S   G  +  V+ L+++H+A +   A  E R  ++
Sbjct: 2048 LEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSL 2107



 Score =  268 bits (684), Expect = 6e-71
 Identities = 283/1183 (23%), Positives = 497/1183 (42%), Gaps = 66/1183 (5%)

Query: 11   TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDE 70
            ++++++  +  +  R++R  EL   R++++      +    +  E+   ++EK +     
Sbjct: 954  SSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAV--- 1010

Query: 71   NYKDPTNLQGKLQ-KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
              +      G LQ +    EA +QA       L E   L+       +  +     EL  
Sbjct: 1011 --ESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGA 1068

Query: 130  QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDW-INDKEAIVTSE-ELGQDLEHVEVL 187
            +W  L    +  G  +  A +L ++L + +  +DW +  +EA   SE  L   LE  + L
Sbjct: 1069 EWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADAL 1128

Query: 188  QKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE---LIKTKQDEVNAAWQRLKGLA 244
              +    + ++   EE    +   +  L+     E      +      +   W +L GL 
Sbjct: 1129 LARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLW 1188

Query: 245  LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDL 304
              R+  L  A   Q F RD+ + +  ++ +E  ++  +    + SV+  L++H      +
Sbjct: 1189 EARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTM 1248

Query: 305  AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
               + K++     A+ L +   +   Q Q     L+   ++ +  A +   +L+D   LQ
Sbjct: 1249 ELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ 1308

Query: 365  RFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESG 424
             FL D  +L  W+ E K L+  D    D         RHQ    E+  +++  +  +  G
Sbjct: 1309 HFLRDCHELDGWIHE-KMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREG 1367

Query: 425  QALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
            Q L+      +  VR+KL  + +  A L    + + +Q  +        +   ++D  + 
Sbjct: 1368 QQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL 1427

Query: 485  KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
              E+ L + D G  L +V + LKK +  E  +     ++  L +  T  +     + E V
Sbjct: 1428 HMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGEL-QAQTAALPLEPASKELV 1486

Query: 545  ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD-EAYKD 603
              R++A+  R   L E    RR  L  S  L Q   D D+  +WV E++  A   E    
Sbjct: 1487 GERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG 1546

Query: 604  PSNLQGKVQKHQAFEAELSANQSRID-ALEKAGQKLIDVNHYAKDEVAARMNEVISLWKK 662
               +Q  ++K+Q    E+ A+  R++  LE+AG  L  +     + V   + ++ S W  
Sbjct: 1547 LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAVRRGLEQLQSAWAG 1605

Query: 663  LLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHAL 722
            L EA E +   L  A Q +Q+  +V ++E WL E E  + S+D GKD  +   L KKH  
Sbjct: 1606 LREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ 1665

Query: 723  LEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
            LE  V  +++ I  ++ Q R   + GH D+E I ++Q  +   Y ALKE    R+  L  
Sbjct: 1666 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 1725

Query: 783  SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAE--IAGHEPRI 840
               L QL R V + E WI EKE +A S   G+D   V  L +K     +E  +AG E R+
Sbjct: 1726 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRE-RL 1784

Query: 841  KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
             AV Q  + ++E GH AA  +      LN+ W  L      R Q L  S +  ++F+DA 
Sbjct: 1785 AAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 1844

Query: 901  EAESWMREKEP-IVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-- 957
            E +  + EK   +   T   +   SA ++ +   A   DL    S ++ L+E A   R  
Sbjct: 1845 ELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTV 1904

Query: 958  ------QQVAPTDDET---GKELVLALYDYQ------------EKSPREVTMKKGDILTL 996
                  + +A  + E     KEL+ A  D +                R++      I + 
Sbjct: 1905 YAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQ 1964

Query: 997  LNSTNK--DWWKVEV--NDRQGFVPA--AYVKKLDPAQSASRENLLEEQGSIALRQEQID 1050
            + + +K  D   VEV  N  QG      A V +L   Q   R  LL +       Q Q+D
Sbjct: 1965 IGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLD 2024

Query: 1051 NQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEK 1110
                       +  R ++V E +       ++    L++  +     +EA     W+  +
Sbjct: 2025 K----------LGTRKEEVSEKW-------DRHWEWLQQMLEVHQFAQEAVVADAWLTAQ 2067

Query: 1111 EAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKV 1153
            E  L S E+G+ +++VE L ++ + F+K   A E R   + ++
Sbjct: 2068 EPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRL 2110



 Score =  223 bits (569), Expect = 1e-57
 Identities = 149/527 (28%), Positives = 262/527 (49%), Gaps = 10/527 (1%)

Query: 12   AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDE 70
            AE ++   +Q+   +   +E +  R+Q L+ +++ + +  D  E+E W+ +++L + S++
Sbjct: 1589 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 1648

Query: 71   NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
              KD  +    L+KH   E  V+    +I +L      ++  GH  SE I  R  ++ R 
Sbjct: 1649 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708

Query: 131  WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
            +  L E   E+ + L Q   L Q  R+  ++  WI +KE +  S ELGQD EHV VLQ+K
Sbjct: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768

Query: 191  FEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
            F EF ++   A  ER+  VNQ   +LI+  H     +   +D +N AW  L  L   R  
Sbjct: 1769 FSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQ 1828

Query: 250  KLFGAAEVQRFNRDVDETISWIKEKEQ----LMASDDFGRDLASVQALLRKHEGLERDLA 305
             L  + E+ +F  D  E    I+EK +    L    +     +S+Q  LR     E DL 
Sbjct: 1829 LLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQ 1885

Query: 306  ALEDKVKALCAEADRLQQSHPLS-ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
             L  +V+ L   A +L+  +    A  I  + +E++  W+++ +   +    ++ +    
Sbjct: 1886 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 1945

Query: 365  RFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESG 424
            RF +  RDL SW+  + + I A +   DV+  E L++ HQ  K E++A      +  E G
Sbjct: 1946 RFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELG 2005

Query: 425  QALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
            ++LL      +DE++ +L  L   +  + E W+   +  +Q +++  F ++    D W++
Sbjct: 2006 RSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLT 2065

Query: 485  KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
             QE  L + +LG S+D VE L+++HE F K+ +A EE+ ++L    T
Sbjct: 2066 AQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT 2112



 Score = 41.6 bits (96), Expect = 0.010
 Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 9/142 (6%)

Query: 2180 LEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCM 2239
            +++ W  L+K   ERE  L+ E  RQE+ + L Q F         W+ E +  +      
Sbjct: 399  IDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQ---- 454

Query: 2240 VEESGTLESQLEATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGL 2295
             +  G     +EA  +KH+    +I A   +++ + +L  A+      D +        +
Sbjct: 455  -DNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSV 513

Query: 2296 AQQWDQLDQLGMRMQHNLEQQI 2317
             +QW  L  L    +  LEQ +
Sbjct: 514  LRQWALLTGLVGARRTRLEQNL 535



 Score = 35.8 bits (81), Expect = 0.54
 Identities = 62/333 (18%), Positives = 126/333 (37%), Gaps = 27/333 (8%)

Query: 1954 SKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDL 2013
            SKMK L  +   + K   Q    L+      ++   A  + +WI      +    +   L
Sbjct: 285  SKMKALAVEGKRIGKVLDQ---VLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSL 341

Query: 2014 SSVQTLL---TKQETFDAGLQAFQQEGIANIT--ALKDQLLAAKHVQSKAIEARHA-SLM 2067
            S VQ  L   T   T +  ++ FQ++G   +   +++ +L A         E      + 
Sbjct: 342  SGVQQQLQAFTAYCTLEKPVK-FQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDID 400

Query: 2068 KRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNS 2127
            K W +L      R+  L        K+E L   F  K +   SW    +  ++       
Sbjct: 401  KAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYE 460

Query: 2128 LEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL 2187
            L  ++A  + H+A  + +++ +     +AEL + + +             +++   W  L
Sbjct: 461  LPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALL 520

Query: 2188 QKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSC--------- 2238
              ++  R       + R E+N  L++ F Q       W++E +  LL   C         
Sbjct: 521  TGLVGAR-------RTRLEQNLALQKVF-QEMVYMVDWMEEMQAQLLSRECGQHLVEADD 572

Query: 2239 MVEESGTLESQLEATKRKHQEIRAMRSQLKKIE 2271
            ++++ G LE  + A   + + + A   +  +++
Sbjct: 573  LLQKHGLLEGDIAAQSERVEALNAAALRFSQLQ 605


>gi|12025678 actinin, alpha 4 [Homo sapiens]
          Length = 911

 Score =  290 bits (741), Expect = 2e-77
 Identities = 166/499 (33%), Positives = 275/499 (55%), Gaps = 17/499 (3%)

Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
            +F  KA + E+W   KE  LK  DY    LS ++ L+ K E F++ L A  Q+ +  I A
Sbjct: 417  KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAA-HQDRVEQIAA 475

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            +  +L    +  S  +  R   +  +W  L + + +R++ L + +     ++ L L +AK
Sbjct: 476  IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535

Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIK 2163
            +A+ FN+W E+A EDL D    +++EEI+ L  AHD F+S+L  A  +   +  + ++ +
Sbjct: 536  RAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQ 595

Query: 2164 SFRVA-------SNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2216
                +       SNPYT  T + +   W  +Q+++ +R+  L +EQ +Q+ N+ LR++FA
Sbjct: 596  RIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFA 655

Query: 2217 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2276
              AN    WIQ     +  G   +E +GTLE QL   K+  + I   +  L  +E     
Sbjct: 656  SQANVVGPWIQTKMEEI--GRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQL 713

Query: 2277 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2336
            ++EALI DNK+T ++   +   W+QL     R  + +E QI  R+  G+++E ++EF   
Sbjct: 714  IQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRAS 773

Query: 2337 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2396
            F HFDKD  G L  +EFK+CL SLGYD+    +GE   EF  I+  VDPN  G V+ Q +
Sbjct: 774  FNHFDKDHGGALGPEEFKACLISLGYDVENDRQGE--AEFNRIMSLVDPNHSGLVTFQAF 831

Query: 2397 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2456
            + FM SRET +  +++++ ++F+ L+ + K ++T EEL + L  +QA+YC++ M PY   
Sbjct: 832  IDFM-SRETTDTDTADQVIASFKVLAGD-KNFITAEELRRELPPDQAEYCIARMAPYQGP 889

Query: 2457 KGRELPTAFDYVEFTRSLF 2475
                +P A DY  F+ +L+
Sbjct: 890  DA--VPGALDYKSFSTALY 906



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 121/611 (19%), Positives = 242/611 (39%), Gaps = 107/611 (17%)

Query: 1693 KDLASVNNLLKKH--QLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGR 1750
            KD  + N L+ +H  +L+E D    +D + +LN+  +  +     D  ++ D  D +N  
Sbjct: 193  KDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFE--VAEKYLDIPKMLDAEDIVNTA 250

Query: 1751 FQKIKSM-------------------AASRRAKL-----NESHRLHQFFRDMDDEESWIK 1786
                K++                   AA+R  K+        H +  + +   D   WI+
Sbjct: 251  RPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIR 310

Query: 1787 E--------------KKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL----------AAHE 1822
                           +++    ED+ RD   V    K  ++ + E+           ++ 
Sbjct: 311  RTIPWLEDRVPQKTIQEMQQKLEDF-RDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNR 369

Query: 1823 PAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHW--KELKQLAAARGQRLEESLEYQQF 1880
            PA       GK +SD N  G + ++Q    + E W   E+++L     +RL+   E  +F
Sbjct: 370  PAFMP--SEGKMVSDINN-GWQHLEQAEKGY-EEWLLNEIRRL-----ERLDHLAE--KF 418

Query: 1881 VANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQ 1939
                   EAW + K  ++   DY   TL+ I+ L++KHEAFE+D   H+DRV  +    Q
Sbjct: 419  RQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQ 478

Query: 1940 DLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE--------NSAFLQFNWKAD 1991
            +L + + +   N++++ + +  +   L      R+  L++        +   L++  +A 
Sbjct: 479  ELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAA 538

Query: 1992 VVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2051
               +W+      L+       +  ++ L++  + F + L    +E        ++ +LA 
Sbjct: 539  PFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADRE--------REAILAI 590

Query: 2052 KHVQSKAIEARHASLM--------------KRWSQLLANSAARKKKLLEAQSHFRKVEDL 2097
                 +  E+ H  L                +W ++      R   LLE QS  +  E L
Sbjct: 591  HKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHL 650

Query: 2098 FLTFAKKASAFNSWFENAEEDL-TDPVRCNSL--EEIKALREAHDAFRSSLSSAQADFNQ 2154
               FA +A+    W +   E++    +  N    +++  L++    +  S+   + + + 
Sbjct: 651  RRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ----YERSIVDYKPNLDL 706

Query: 2155 LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEE---NDKL 2211
            L +  + I+   +  N +T +TME +   W  L   I     E++ +   ++    + + 
Sbjct: 707  LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQ 766

Query: 2212 RQEFAQHANAF 2222
             QEF    N F
Sbjct: 767  MQEFRASFNHF 777



 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 104/487 (21%), Positives = 206/487 (42%), Gaps = 76/487 (15%)

Query: 154 YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE----- 207
           Y +   D+++WI  +  I   E+     + ++ +Q+K E+F+     H+  +V E     
Sbjct: 298 YEKLASDLLEWI--RRTIPWLEDRVPQ-KTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLE 354

Query: 208 --VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRL----KGLA------LQRQGKLFGA 254
              N    KL     P     + K   ++N  WQ L    KG        ++R  +L   
Sbjct: 355 INFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHL 414

Query: 255 AEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALEDKVKA 313
           AE  R    + E  +W   KE ++   D+    L+ ++AL+RKHE  E DLAA +D+V+ 
Sbjct: 415 AEKFRQKASIHE--AWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQ 472

Query: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR----------- 362
           + A A  L +     +  +  + +++   W+ + +L   R   L  + +           
Sbjct: 473 IAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLE 532

Query: 363 -----------LQRFLADFRD--LTSWVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408
                      ++  + D +D  +   + E++ LI+A D+  S       L D  +E + 
Sbjct: 533 YAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKS------TLPDADREREA 586

Query: 409 EIDAHEDSFKSADESGQALLAAGHYAS------DEVREKLTVLSEER-AALLELWELRRQ 461
            +  H+++ + A+ +   L  +  Y +      +   EK+  L  +R  ALLE  E  +Q
Sbjct: 587 ILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE--EQSKQ 644

Query: 462 QYEQCMDLQLFYRDTEQVDNWM--SKQEAFLLNEDLGDSLDSVEALLKKHE----DFEKS 515
           Q  + +  Q F      V  W+    +E   ++ ++  +L+   + LK++E    D++ +
Sbjct: 645 QSNEHLRRQ-FASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPN 703

Query: 516 LSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLS----RRNALHERAMRRRAQLAD 571
           L   E++   + E      ++ +Y ME +    + LL+      N +  + + R A+   
Sbjct: 704 LDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGIS 763

Query: 572 SFHLQQF 578
              +Q+F
Sbjct: 764 QEQMQEF 770



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 9/137 (6%)

Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
            + ++N  W+ L+Q        L  E  +L    H  ++F + A   + W + K   L   
Sbjct: 380  VSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHR 439

Query: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
            +Y    L+ ++AL RKHE FE DLAA  D+V  +   A+ L +     + ++  +C ++ 
Sbjct: 440  DYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKIC 499

Query: 1319 QAWSSLGKRADQRKAKL 1335
              W +LG     R+  L
Sbjct: 500  DQWDALGSLTHSRREAL 516



 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 72/340 (21%), Positives = 137/340 (40%), Gaps = 38/340 (11%)

Query: 1645 WQFLVQKSAEKSQK---LKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK- 1693
            WQ L Q  AEK  +   L E  + +  +   + F       + W    EA+L   DY   
Sbjct: 387  WQHLEQ--AEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETA 444

Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
             L+ +  L++KH+  E+D++AH+DR++ + + A  L     +D+  V  +   I  ++  
Sbjct: 445  TLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDA 504

Query: 1754 IKSMAASRRAKLNESHR-------LH-QFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ 1805
            + S+  SRR  L ++ +       LH ++ +      +W++     +        +  ++
Sbjct: 505  LGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIE 564

Query: 1806 NLRKKHKRLEAELA---AHEPAIQGVLDTGKKLSDDNTI---GKEEIQQRLAQFV-EHWK 1858
             L   H + ++ L        AI  +    +++++ N I   G         Q +   W+
Sbjct: 565  GLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWE 624

Query: 1859 ELKQLAAARGQRLEESLEYQ--------QFVANVEEEEAWINEKMTLVA--SEDYGDTLA 1908
            +++QL   R   L E    Q        QF +       WI  KM  +   S +   TL 
Sbjct: 625  KVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLE 684

Query: 1909 AIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHH 1948
                 LK++E    D+  + D +       Q+ +  +N H
Sbjct: 685  DQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKH 724



 Score = 58.5 bits (140), Expect = 8e-08
 Identities = 62/301 (20%), Positives = 122/301 (40%), Gaps = 31/301 (10%)

Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
           ++F +     E W    E  L   DY    L++++ L +KH   E+D+AAHQDR++ I  
Sbjct: 416 EKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAA 475

Query: 740 QARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL---------ADSLRLQQLF 790
            A++  +  ++D+ N+  + + +  +++AL     +R++ L          D L L+   
Sbjct: 476 IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535

Query: 791 RDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG---HEPRIKAVTQKG 847
           R       W+               +  ++ L+  H   ++ +         I A+ ++ 
Sbjct: 536 R-AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEA 594

Query: 848 NAMVEEGHFAAED----VKAKLHELNQKWEALKAKASQRRQDL--EDSLQ------AQQY 895
             + E  H                +N KWE ++    +R   L  E S Q       +Q+
Sbjct: 595 QRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQF 654

Query: 896 FADANEAESWMREKEPIVG--STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQA 953
            + AN    W++ K   +G  S +     +   + LK++E  + D   Y  ++  L +Q 
Sbjct: 655 ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVD---YKPNLDLLEQQH 711

Query: 954 Q 954
           Q
Sbjct: 712 Q 712



 Score = 56.2 bits (134), Expect = 4e-07
 Identities = 48/250 (19%), Positives = 105/250 (42%), Gaps = 14/250 (5%)

Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
            ++R   LD   E   F +     E W   +EA L   D +  +L  ++ALI+KHE F+  
Sbjct: 405  IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462

Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL------KAQMIEKRSKL 1547
            +   ++++  + A A +L    +Y   ++++R  ++ D+W  L      + + +EK  K 
Sbjct: 463  LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQ 522

Query: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
             E+  Q   ++++       W+   ++   D  +   T  ++  L+S H + ++   +  
Sbjct: 523  LEAIDQLHLEYAKRAAPFNNWMESAMEDLQD-MFIVHTIEEIEGLISAHDQFKSTLPDAD 581

Query: 1606 ANADRIRGVIDMGNSLIERG--ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
               + I  +      + E      +GS          +  +W+ + Q   ++   L E  
Sbjct: 582  REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641

Query: 1664 KQQNFNTGIK 1673
             +Q  N  ++
Sbjct: 642  SKQQSNEHLR 651



 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 74/408 (18%), Positives = 157/408 (38%), Gaps = 47/408 (11%)

Query: 3   PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
           PS  K++    +  +  +Q    Y  +  L+ +RR +  D    +F Q+ A   E W   
Sbjct: 374 PSEGKMVSDINNGWQHLEQAEKGYEEWL-LNEIRRLERLDHLAEKFRQK-ASIHEAWTDG 431

Query: 63  KLQIASDENYKDPT--NLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
           K  +    +Y+  T  +++  ++KH+AFE+++ A+   + ++      +    ++ S  +
Sbjct: 432 KEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNV 491

Query: 121 RTRLMELHRQWELL------LEKMREKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172
            TR  ++  QW+ L        +  EK  K L+A  Q  ++Y +      +W+      +
Sbjct: 492 NTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDL 551

Query: 173 TSEELGQDLEHVEVLQKKFEEFQT---DMAAHEERVNEVNQFAAKLIQEQH----PEEEL 225
               +   +E +E L    ++F++   D     E +  +++ A ++ +  H         
Sbjct: 552 QDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPY 611

Query: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277
                  +N+ W++++ L  +R   L      Q+ N  +    +        WI+ K   
Sbjct: 612 TTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTK--- 668

Query: 278 MASDDFGRDLASVQALLRKH----EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQ 333
              ++ GR    +   L       +  ER +   +  +  L  +   +Q++         
Sbjct: 669 --MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTN 726

Query: 334 VKREELITNWEQIRTLAAE-----------RHARLNDSYRLQRFLADF 370
              E +   WEQ+ T  A            R A+     ++Q F A F
Sbjct: 727 YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASF 774



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 75/369 (20%), Positives = 149/369 (40%), Gaps = 63/369 (17%)

Query: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621
           RR +  D  HL + FR    + ++W + K        Y+    S+++  ++KH+AFE++L
Sbjct: 406 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDL 463

Query: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW----------KKLLEATE--- 668
           +A+Q R++ +    Q+L ++++Y    V  R  ++   W          ++ LE TE   
Sbjct: 464 AAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL 523

Query: 669 --LKGIKLREANQQQQFNRNVED---------IELWLYEVEGHLASDDYGKDLTNVQNLQ 717
             +  + L  A +   FN  +E          I   + E+EG +++ D           Q
Sbjct: 524 EAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHD-----------Q 572

Query: 718 KKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENI---------------KKKQEAL 762
            K  L +AD    ++ I  I  +A++  ++ H                     +K Q+ +
Sbjct: 573 FKSTLPDAD--REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLV 630

Query: 763 VARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK-EPIAASTNRGKDLIGVQN 821
             R  AL E     KQ+  + LR +Q          WI+ K E I   +      +  ++
Sbjct: 631 PKRDHALLEEQ--SKQQSNEHLR-RQFASQANVVGPWIQTKMEEIGRISIEMNGTL--ED 685

Query: 822 LLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQ 881
            L   +  +  I  ++P +  + Q+   + E   F  +     +  +   WE L    ++
Sbjct: 686 QLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIAR 745

Query: 882 RRQDLEDSL 890
              ++E+ +
Sbjct: 746 TINEVENQI 754



 Score = 36.2 bits (82), Expect = 0.41
 Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 2/78 (2%)

Query: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDS-AEALLKKHEALMSDLS 940
           RR +  D L A+++   A+  E+W   KE ++   DY     S  +AL++KHEA  SDL+
Sbjct: 406 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLA 464

Query: 941 AYGSSIQALREQAQSCRQ 958
           A+   ++ +   AQ   +
Sbjct: 465 AHQDRVEQIAAIAQELNE 482



 Score = 34.7 bits (78), Expect = 1.2
 Identities = 50/256 (19%), Positives = 101/256 (39%), Gaps = 52/256 (20%)

Query: 1019 AYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSL 1076
            A ++K +  +S  A+ ++ +E+  +IA    ++D       ++ +V+ R +++ + + +L
Sbjct: 451  ALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYY-----DSHNVNTRCQKICDQWDAL 505

Query: 1077 LELGEKRKGMLEKSCKKFMLF--------REANELQQWINEKEAALTSEEVGADLEQVEV 1128
              L   R+  LEK+ K+            + A     W+      L    +   +E++E 
Sbjct: 506  GSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEG 565

Query: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
            L    D F+       S L D      D E E ++A   +A +  E   +         T
Sbjct: 566  LISAHDQFK-------STLPDA-----DREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613

Query: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLA--------EERSQLLGSAHEVQRFHR 1240
             +P                 + +N +W  +QQL         EE+S+   + H  ++F  
Sbjct: 614  VTP-----------------QIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFAS 656

Query: 1241 DADETKEWIEEKNQAL 1256
             A+    WI+ K + +
Sbjct: 657  QANVVGPWIQTKMEEI 672


>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
          Length = 892

 Score =  288 bits (738), Expect = 4e-77
 Identities = 167/501 (33%), Positives = 282/501 (56%), Gaps = 21/501 (4%)

Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
            +F  KA + E+W   KE  L+  DY    LS ++ LL K E F++ L A  Q+ +  I A
Sbjct: 398  KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRVEQIAA 456

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            +  +L    +  S ++ AR   +  +W  L A +  R++ L   +     ++ L+L +AK
Sbjct: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516

Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA------E 2157
            +A+ FN+W E A EDL D    +++EEI+ L  AH+ F+++L  A  D  +LA      E
Sbjct: 517  RAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA--DKERLAILGIHNE 574

Query: 2158 LDRQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQE 2214
            + + ++++ V    +NPYT  T + +   W ++++++  R+  L +E  RQ+ N++LR++
Sbjct: 575  VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634

Query: 2215 FAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
            F   AN    WIQ     +  G   +E  GTLE QL   ++  + I   + ++ ++E   
Sbjct: 635  FGAQANVIGPWIQTKMEEI--GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692

Query: 2275 AAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFS 2334
              ++EALI DNK+T ++   +   W+QL     R  + +E QI  R+  G+++E + EF 
Sbjct: 693  QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR 752

Query: 2335 MMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQ 2394
              F HFD+D SG L  +EFK+CL SLGYD+    +GE   EF  I+  VDPNR G V+ Q
Sbjct: 753  ASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGE--AEFARIMSIVDPNRLGVVTFQ 810

Query: 2395 EYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYV 2454
             ++ FM SRET +  +++++ ++F+ L+ + K Y+T +EL + L  +QA+YC++ M PY 
Sbjct: 811  AFIDFM-SRETADTDTADQVMASFKILAGD-KNYITMDELRRELPPDQAEYCIARMAPYT 868

Query: 2455 DGKGRELPTAFDYVEFTRSLF 2475
                  +P A DY+ F+ +L+
Sbjct: 869  GPD--SVPGALDYMSFSTALY 887



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 83/382 (21%), Positives = 162/382 (42%), Gaps = 47/382 (12%)

Query: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFT 1925
            R +RL+   E  +F       EAW + K  ++  +DY   TL+ I+ LLKKHEAFE+D  
Sbjct: 388  RLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445

Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE 1979
             H+DRV  +    Q+L + + +   +++++ + +       G ++   + A +R  KL E
Sbjct: 446  AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505

Query: 1980 --NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
              +  +L++  +A    +W+      L+       +  +Q L T  E F A L    +E 
Sbjct: 506  TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565

Query: 2038 IANITALKDQLLAAKHVQSKAIEARHASLM--------------KRWSQLLANSAARKKK 2083
            +A        +L   +  SK ++  H ++                +W  +      R + 
Sbjct: 566  LA--------ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA 617

Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDA 2140
            L E  +  +  E L   F  +A+    W +   E+   ++  +     +++  LR+    
Sbjct: 618  LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ---- 673

Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL----QKIIKEREL 2196
            +  S+ + +   +QL    + I+   +  N +T +TME +   W  L     + I E E 
Sbjct: 674  YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733

Query: 2197 ELQKEQRR---QEENDKLRQEF 2215
            ++     +   QE+ ++ R  F
Sbjct: 734  QILTRDAKGISQEQMNEFRASF 755



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 50/250 (20%), Positives = 110/250 (44%), Gaps = 14/250 (5%)

Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
            ++R   LD   E   F +     E W   +EA L  +D +  +L  ++AL+KKHE F+  
Sbjct: 386  IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443

Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKA------QMIEKRSKL 1547
            +   ++++  + A A +L    +Y    +++R  ++ D+W  L A      + +E+  KL
Sbjct: 444  LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503

Query: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
             E+  Q   ++++       W+   ++   D ++   T  ++  L + H++ +A   +  
Sbjct: 504  LETIDQLYLEYAKRAAPFNNWMEGAMEDLQD-TFIVHTIEEIQGLTTAHEQFKATLPDAD 562

Query: 1606 ANADRIRGVIDMGNSLIE--RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
                 I G+ +  + +++      AG+          +  +W  + Q    + Q L E +
Sbjct: 563  KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622

Query: 1664 KQQNFNTGIK 1673
             +Q  N  ++
Sbjct: 623  ARQQHNERLR 632



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 9/137 (6%)

Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
            + ++N  W  L+Q        L  E  +L    H  ++F + A   + W + K   L   
Sbjct: 361  VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420

Query: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
            +Y    L+ ++AL +KHE FE DLAA  D+V  +   A+ L +     +  +  +C ++ 
Sbjct: 421  DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480

Query: 1319 QAWSSLGKRADQRKAKL 1335
              W +LG    +R+  L
Sbjct: 481  DQWDNLGALTQKRREAL 497



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 72/348 (20%), Positives = 142/348 (40%), Gaps = 49/348 (14%)

Query: 357 LNDSYRLQRF--LAD-FRDLTS----WVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408
           LN+  RL+R   LA+ FR   S    W    +A++   D   + ++  +ALL +H+  + 
Sbjct: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFES 442

Query: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468
           ++ AH+D  +      Q L    +Y S  V  +   + ++   L  L + RR+  E+   
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502

Query: 469 L-----QLFYRDTEQV---DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQ 519
           L     QL+    ++    +NWM      L +  +  +++ ++ L   HE F+ +L  A 
Sbjct: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562

Query: 520 EEK--ITALDEFATKLIQNNHYAM---------------------EDVATRRDALLSRRN 556
           +E+  I  +    +K++Q  H  M                       +  RRD  L+  +
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622

Query: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
           A  +   R R         +QF   ++ +  W+  KM+     + +    L+ ++   + 
Sbjct: 623 ARQQHNERLR---------KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ 673

Query: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
           +E  +   + +ID LE   Q + +   +        M  +   W++LL
Sbjct: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 84/389 (21%), Positives = 154/389 (39%), Gaps = 44/389 (11%)

Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
            Q++E   KL  S  L+   R +  +E  + E    A  +  +D  +    + L K  K Q
Sbjct: 274  QLMEDYEKLA-SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY---RRLHKPPKVQ 329

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657
              + +L  N + ++  + + N    R A   SE  +   ++ + + W  L Q +   +  
Sbjct: 330  E-KCQLEINFNTLQTKLRLSN----RPAFMPSEGRM---VSDINNAWGCLEQVEKGYEEW 381

Query: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLE 1709
             L E  + +  +   + F       + W    EA+L  +DY    L+ +  LLKKH+  E
Sbjct: 382  LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441

Query: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769
            +D++AH+DR++ + + A  L     +D+  V  +   I  ++  + ++   RR  L  + 
Sbjct: 442  SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501

Query: 1770 RLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821
            +L +    +  E         +W++     +        +  +Q L   H++ +A L   
Sbjct: 502  KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561

Query: 1822 EP---AIQGVLDTGKKLSDD---NTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEES 1874
            +    AI G+ +   K+      N  G         Q +   W  ++QL   R Q L E 
Sbjct: 562  DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621

Query: 1875 LEYQ--------QFVANVEEEEAWINEKM 1895
               Q        QF A       WI  KM
Sbjct: 622  HARQQHNERLRKQFGAQANVIGPWIQTKM 650



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 25/235 (10%)

Query: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE 207
           Q +  Y +   D+++WI  +        + ++  H   +Q+K E+F+     H+  +V E
Sbjct: 274 QLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHA--MQQKLEDFRDYRRLHKPPKVQE 330

Query: 208 -------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRLKGLA----------LQRQG 249
                   N    KL     P     + +   ++N AW  L+ +           ++R  
Sbjct: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390

Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALE 308
           +L   AE  R    + E  +W   KE ++   D+    L+ ++ALL+KHE  E DLAA +
Sbjct: 391 RLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448

Query: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
           D+V+ + A A  L +     +  +  + +++   W+ +  L  +R   L  + +L
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 68/347 (19%), Positives = 143/347 (41%), Gaps = 31/347 (8%)

Query: 32  LSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPT--NLQGKLQKHQAFE 89
           L+ +RR +  D    +F Q+ A   E W   K  +   ++Y+  T   ++  L+KH+AFE
Sbjct: 383 LNEIRRLERLDHLAEKFRQK-ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441

Query: 90  AEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE---LLLEKMR---EKGI 143
           +++ A+   + ++      +    ++ S ++  R  ++  QW+    L +K R   E+  
Sbjct: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501

Query: 144 KLLQA--QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMA-A 200
           KLL+   Q  ++Y +      +W+      +    +   +E ++ L    E+F+  +  A
Sbjct: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561

Query: 201 HEER--VNEVNQFAAKLIQEQHPE----EELIKTKQDEVNAAWQRLKGLALQRQGKLFGA 254
            +ER  +  ++   +K++Q  H               E+N  W  ++ L  +R   L   
Sbjct: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621

Query: 255 AEVQRFNRDVDETIS--------WIKEKEQLMA--SDDFGRDLASVQALLRKHEGLERDL 304
              Q+ N  + +           WI+ K + +   S +    L    + LR++   E+ +
Sbjct: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQY---EKSI 678

Query: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
              + K+  L  +   +Q++            E +   WEQ+ T  A
Sbjct: 679 VNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 57/286 (19%), Positives = 118/286 (41%), Gaps = 31/286 (10%)

Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
           ++F +     E W    E  L   DY    L+ ++ L KKH   E+D+AAHQDR++ I  
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456

Query: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQLFRDV 793
            A++  +  ++D+ ++  + + +  +++ L      +   + R +KL ++  + QL+ + 
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET--IDQLYLEY 514

Query: 794 EDE----ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR---IKAVTQK 846
                    W+         T     +  +Q L   H+  +A +   +     I  +  +
Sbjct: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE 574

Query: 847 GNAMVEEGHFAAEDVKAKL----HELNQKWEALKAKASQRRQDLEDSLQAQ--------Q 894
            + +V+  H               E+N KW+ ++    +R Q L +    Q        Q
Sbjct: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634

Query: 895 YFADANEAESWMREKEPIVGSTD---YGKDEDSAEALLKKHEALMS 937
           + A AN    W++ K   +G      +G  ED    L +  +++++
Sbjct: 635 FGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVN 680



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 65/317 (20%), Positives = 127/317 (40%), Gaps = 34/317 (10%)

Query: 482 WMSKQEAFLLNEDLGDS-LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
           W   +EA L  +D   + L  ++ALLKKHE FE  L+A ++++  +   A +L + ++Y 
Sbjct: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468

Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWVNE 591
              V  R   +  + + L     +RR  L          D  +L ++ + +    +W+  
Sbjct: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYL-EYAKRAAPFNNWMEG 527

Query: 592 KMKTATDE-AYKDPSNLQGKVQKHQAFEAEL-SANQSRIDAL--EKAGQKLIDVNHY--- 644
            M+   D         +QG    H+ F+A L  A++ R+  L       K++   H    
Sbjct: 528 AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA 587

Query: 645 -AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVED--------IELWL- 694
                      E+   W  + +    +   L E + +QQ N  +          I  W+ 
Sbjct: 588 GTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQ 647

Query: 695 --YEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDA 752
              E  G ++ + +G     + +L++     E  +  ++ +ID +    +  Q+A  FD 
Sbjct: 648 TKMEEIGRISIEMHGTLEDQLSHLRQ----YEKSIVNYKPKIDQLEGDHQLIQEALIFDN 703

Query: 753 ENIKKKQEALVARYEAL 769
           ++     E +   +E L
Sbjct: 704 KHTNYTMEHIRVGWEQL 720



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 65/326 (19%), Positives = 136/326 (41%), Gaps = 54/326 (16%)

Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093
            N L+ +  ++ R   + ++ R+  +  +    ++QVE+ Y   L    +R   L+   +K
Sbjct: 339  NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398

Query: 1094 FMLFREANELQQWINEKEAALTSEEVG-ADLEQVEVLQKKFDDFQKDLKANESRLKDINK 1152
            F   ++A+  + W + KEA L  ++   A L +++ L KK + F+ DL A++ R++ I  
Sbjct: 399  FR--QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456

Query: 1153 VAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELN 1212
            +A++L              + + Y             SP  +AR            +++ 
Sbjct: 457  IAQELN-------------ELDYYD------------SPSVNARC-----------QKIC 480

Query: 1213 ERWRSLQQLAEERSQLLGSAHEVQR--------FHRDADETKEWIEEKNQALNTDNYGHD 1264
            ++W +L  L ++R + L    ++          + + A     W+E   + L      H 
Sbjct: 481  DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540

Query: 1265 LASVQALQRKHEGFERDLA-ALGDKVNSLG--ETAERLIQSHPESAEDLQEKCT----EL 1317
            +  +Q L   HE F+  L  A  +++  LG      +++Q++  +        T    E+
Sbjct: 541  IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600

Query: 1318 NQAWSSLGKRADQRKAKLGDSHDLQR 1343
            N  W  + +   +R   L + H  Q+
Sbjct: 601  NGKWDHVRQLVPRRDQALTEEHARQQ 626



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 9/121 (7%)

Query: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621
           RR +  D  HL + FR    + ++W + K      + Y+    S ++  ++KH+AFE++L
Sbjct: 387 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444

Query: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
           +A+Q R++ +    Q+L ++++Y    V AR  ++   W  L   T+    K REA ++ 
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ----KRREALERT 500

Query: 682 Q 682
           +
Sbjct: 501 E 501



 Score = 48.5 bits (114), Expect = 8e-05
 Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 8/114 (7%)

Query: 776 RKQKLADSLRLQQLFRDV--EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEI 833
           R   LA+  R +    +   + +E  +R+K+   A+ +       ++ LLKKH+A ++++
Sbjct: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE------IKALLKKHEAFESDL 444

Query: 834 AGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
           A H+ R++ +      + E  ++ +  V A+  ++  +W+ L A   +RR+ LE
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 55/290 (18%), Positives = 115/290 (39%), Gaps = 32/290 (11%)

Query: 1315 TELNQAWSSLGK-RADQRKAKLGDSHDLQRF---LSDFRDLMS----WINGIRGLV-SSD 1365
            +++N AW  L +      +  L +   L+R       FR   S    W +G   ++   D
Sbjct: 362  SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKD 421

Query: 1366 ELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQ 1425
                 ++  +ALL++H+   +++ A     +      Q+L    +Y SP +  +   +  
Sbjct: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481

Query: 1426 ERADLEKAWVQRRMMLDQCLEL-----QLFHRDCEQA---ENWMAAREAFLNTEDKGDSL 1477
            +  +L     +RR  L++  +L     QL+    ++A    NWM      L       ++
Sbjct: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541

Query: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAAL----------QAFADQLIAAGHY---AKGDIS 1523
            + ++ L   HE F   + +  +E++A L          Q +   +     Y      +I+
Sbjct: 542  EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601

Query: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQ 1572
             + + V     R    + E+ ++   ++ L +QF    + I  WI  K++
Sbjct: 602  GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKME 651



 Score = 38.5 bits (88), Expect = 0.083
 Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)

Query: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA-EALLKKHEALMSDLS 940
           RR +  D L A+++   A+  E+W   KE ++   DY     S  +ALLKKHEA  SDL+
Sbjct: 387 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445

Query: 941 AYGSSIQALREQAQSCRQ 958
           A+   ++ +   AQ   +
Sbjct: 446 AHQDRVEQIAAIAQELNE 463


>gi|4501893 actinin, alpha 2 [Homo sapiens]
          Length = 894

 Score =  280 bits (717), Expect = 1e-74
 Identities = 165/499 (33%), Positives = 275/499 (55%), Gaps = 22/499 (4%)

Query: 1985 QFNWKADVVESWIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
            +F  KA   E+W   KE  L   DY    L+ V+ LL K E F++ L A  Q+ +  I A
Sbjct: 405  KFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA-HQDRVEQIAA 463

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            +  +L    +  +  +  R   +  +W +L   +  R++ L   +     ++ L L FAK
Sbjct: 464  IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523

Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA----ELD 2159
            +A+ FN+W E A EDL D    +S+EEI++L  AH+ F+++L  A  +   +     E++
Sbjct: 524  RAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVE 583

Query: 2160 RQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2216
            + I+S+ +   +SNPY+  TM+ L   W  +++++  R+  LQ+E  RQ  N++LR++FA
Sbjct: 584  KVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFA 643

Query: 2217 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2276
              ANA   WIQ     +   S  +  +G LE Q+   K+    I   ++ + K+E     
Sbjct: 644  AQANAIGPWIQNKMEEIARSSIQI--TGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQL 701

Query: 2277 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2336
            ++EAL+ DNK+T ++   +   W+ L     R  + +E QI  R+  G+T+E + EF   
Sbjct: 702  IQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQILTRDAKGITQEQMNEFRAS 761

Query: 2337 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2396
            F HFD+ K+G ++H++F++CL S+GYDL        + EF  I+  VDPN  G V+ Q +
Sbjct: 762  FNHFDRRKNGLMDHEDFRACLISMGYDL-------GEAEFARIMTLVDPNGQGTVTFQSF 814

Query: 2397 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2456
            + FM +RET +  ++E++ ++FR L+S+ KPY+  EEL + L  +QA YC+  M  Y  G
Sbjct: 815  IDFM-TRETADTDTAEQVIASFRILASD-KPYILAEELRRELPPDQAQYCIKRMPAY-SG 871

Query: 2457 KGRELPTAFDYVEFTRSLF 2475
             G  +P A DY  F+ +L+
Sbjct: 872  PG-SVPGALDYAAFSSALY 889



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 108/512 (21%), Positives = 213/512 (41%), Gaps = 47/512 (9%)

Query: 1742 DKRDTINGRFQKIKSMAASRRAKLNESHRL-HQFFRDMDDEESWIKEKKLLVGSEDYGRD 1800
            ++ +T   R  K+ ++       + E  RL  +    +     W++ +      +   + 
Sbjct: 260  EQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKK 319

Query: 1801 LTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ---------QRLA 1851
            L   ++ R+KHK  + +           L T  ++S+       E +         QRL 
Sbjct: 320  LEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE 379

Query: 1852 QFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAI 1910
            Q  + ++E       R +RLE   E  +F       E W   K  ++  +DY   +L  +
Sbjct: 380  QAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWAYGKEQILLQKDYESASLTEV 437

Query: 1911 QGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVS 1964
            + LL+KHEAFE+D   H+DRV  +    Q+L + + H   N++ + + +       G ++
Sbjct: 438  RALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLT 497

Query: 1965 DLEKAAAQRKAKLDE--NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTK 2022
               + A +R  KL E  +   L+F  +A    +W+      L+       +  +Q+L+T 
Sbjct: 498  QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITA 557

Query: 2023 QETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHAS---------LMKRWSQL 2073
             E F A L     E   +I A+++++   K +QS  I    ++         L  +W ++
Sbjct: 558  HEQFKATLPEADGER-QSIMAIQNEV--EKVIQSYNIRISSSNPYSTVTMDELRTKWDKV 614

Query: 2074 LANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2133
                  R + L E  +     E L   FA +A+A   W +N  E++      +S++   A
Sbjct: 615  KQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIAR----SSIQITGA 670

Query: 2134 LREAHD---AFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWR----N 2186
            L +  +    +  ++ + + + ++L    + I+   V  N +T +TME +   W      
Sbjct: 671  LEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTT 730

Query: 2187 LQKIIKERELELQKEQRR---QEENDKLRQEF 2215
            + + I E E ++     +   QE+ ++ R  F
Sbjct: 731  IARTINEVETQILTRDAKGITQEQMNEFRASF 762



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 94/445 (21%), Positives = 174/445 (39%), Gaps = 46/445 (10%)

Query: 505 LLKKHEDFEKSLSAQEEKITAL-DEFATKLIQNNHY------AMEDVATRRDALLSRRNA 557
           + +KH D  K L A++   T   DE A     +  Y         + A  R   +   N 
Sbjct: 218 IAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQ 277

Query: 558 LHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAF 617
            +ER M    +LA    L+   R    L++   EK   A  +  +D  + + K +  +  
Sbjct: 278 ENERLMEEYERLASEL-LEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQ 336

Query: 618 E-AELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATE------LK 670
           E  +L  N + +    +   +   +    K      ++++   W++L +A +      L 
Sbjct: 337 EKCQLEINFNTLQTKLRISNRPAFMPSEGK-----MVSDIAGAWQRLEQAEKGYEEWLLN 391

Query: 671 GIKLREANQQ--QQFNRNVEDIELWLYEVEGHLASDDY-GKDLTNVQNLQKKHALLEADV 727
            I+  E  +   ++F +     E W Y  E  L   DY    LT V+ L +KH   E+D+
Sbjct: 392 EIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDL 451

Query: 728 AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
           AAHQDR++ I   A++  +  + DA N+  + + +  +++ L      R++ L    +L 
Sbjct: 452 AAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLL 511

Query: 788 QLFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA---EIAGH 836
           +    +  E          W+               +  +Q+L+  H+  +A   E  G 
Sbjct: 512 ETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGE 571

Query: 837 EPRIKAVTQKGNAMVEEGHFAAEDVK----AKLHELNQKWEALKAKASQRRQDLEDSLQA 892
              I A+  +   +++  +             + EL  KW+ +K     R Q L++ L  
Sbjct: 572 RQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELAR 631

Query: 893 Q--------QYFADANEAESWMREK 909
           Q        Q+ A AN    W++ K
Sbjct: 632 QHANERLRRQFAAQANAIGPWIQNK 656



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 111/557 (19%), Positives = 217/557 (38%), Gaps = 81/557 (14%)

Query: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF---------LNTEDKGDSLDSVEALI 1484
            W QR+    + + +Q FH   +      A              LN +D   +++    + 
Sbjct: 160  WCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEIA 219

Query: 1485 KKHEDFDKAINVQE--------EKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL 1536
            +KH D  K ++ ++        E+             AG       ++R  +VL    + 
Sbjct: 220  EKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVL-AVNQE 278

Query: 1537 KAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQK 1596
              +++E+  +L  S+ L+   R +  +E    EK   A  +  +D  + +      K Q+
Sbjct: 279  NERLMEEYERLA-SELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQE 337

Query: 1597 HQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKS 1656
                + +L  N + ++  + + N    R A   SE  +   ++ +A  WQ L Q  AEK 
Sbjct: 338  ----KCQLEINFNTLQTKLRISN----RPAFMPSEGKM---VSDIAGAWQRLEQ--AEKG 384

Query: 1657 QK---LKEANK-------QQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKH 1705
             +   L E  +        + F       + W    E +L  +DY    L  V  LL+KH
Sbjct: 385  YEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKH 444

Query: 1706 QLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKL 1765
            +  E+D++AH+DR++ + + A  L      D   V D+   I  ++ ++ ++   RR  L
Sbjct: 445  EAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREAL 504

Query: 1766 NESHRLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAE 1817
                +L +    +  E         +W++     +        +  +Q+L   H++ +A 
Sbjct: 505  ERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT 564

Query: 1818 LAAHEPAIQGVL-----------DTGKKLSDDN---TIGKEEIQQRLAQFVEHWKELKQL 1863
            L   +   Q ++               ++S  N   T+  +E++ +       W ++KQL
Sbjct: 565  LPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTK-------WDKVKQL 617

Query: 1864 AAARGQRLEESLEYQ--------QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLK 1915
               R Q L+E L  Q        QF A       WI  KM  +A      T  A++  + 
Sbjct: 618  VPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQIT-GALEDQMN 676

Query: 1916 KHEAFETDFTVHKDRVN 1932
            + + +E +   +K+ ++
Sbjct: 677  QLKQYEHNIINYKNNID 693



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 78/301 (25%), Positives = 130/301 (43%), Gaps = 32/301 (10%)

Query: 153 QYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE---- 207
           +Y R   ++++WI  +  I   E    + + ++ +QKK E+F+     H+  +V E    
Sbjct: 285 EYERLASELLEWI--RRTIPWLENRTPE-KTMQAMQKKLEDFRDYRRKHKPPKVQEKCQL 341

Query: 208 ---VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRL----KGLA------LQRQGKLFG 253
               N    KL     P     + K   ++  AWQRL    KG        ++R  +L  
Sbjct: 342 EINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEH 401

Query: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLRKHEGLERDLAALEDKVK 312
            AE  R      ET  W   KEQ++   D+    L  V+ALLRKHE  E DLAA +D+V+
Sbjct: 402 LAEKFRQKASTHET--WAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVE 459

Query: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372
            + A A  L +     A  +  + +++   W+++ TL  +R   L    R+++ L     
Sbjct: 460 QIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALE---RMEKLLETIDQ 516

Query: 373 L-TSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHED---SFKSADESGQALL 428
           L   +        N  E A +      ++   +E +  I AHE    +   AD   Q+++
Sbjct: 517 LHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIM 576

Query: 429 A 429
           A
Sbjct: 577 A 577



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 83/384 (21%), Positives = 166/384 (43%), Gaps = 55/384 (14%)

Query: 41  EDSYRFQFFQRDAEELEKWIQ-----------EKLQIASDENYKDPTNLQGKLQKHQAFE 89
           E+    + ++R A EL +WI+           EK   A  +  +D  + + K +  +  E
Sbjct: 278 ENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQE 337

Query: 90  -AEVQANSGAI---VKLDETGNLMISEGHFASETIRT--RLMELHRQWE-LLLEKMREKG 142
             +++ N   +   +++      M SEG   S+      RL +  + +E  LL ++R   
Sbjct: 338 KCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR--- 394

Query: 143 IKLLQAQKLVQYLRECEDVMD-WINDKEAIVTSEEL-GQDLEHVEVLQKKFEEFQTDMAA 200
            +L + + L +  R+     + W   KE I+  ++     L  V  L +K E F++D+AA
Sbjct: 395 -RLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAA 453

Query: 201 HEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGL------ALQRQGKLFGA 254
           H++RV ++   A +L +  + +   +  +  ++   W RL  L      AL+R  KL   
Sbjct: 454 HQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLET 513

Query: 255 AEVQR--FNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHE----------GLER 302
            +     F +      +W++   + +        +  +Q+L+  HE          G  +
Sbjct: 514 IDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQ 573

Query: 303 DLAALEDKVKALCAEAD-RLQQSHPLSATQIQVKREELITNWEQIRTLA-------AERH 354
            + A++++V+ +    + R+  S+P S     V  +EL T W++++ L         E  
Sbjct: 574 SIMAIQNEVEKVIQSYNIRISSSNPYST----VTMDELRTKWDKVKQLVPIRDQSLQEEL 629

Query: 355 ARLNDSYRLQR-FLADFRDLTSWV 377
           AR + + RL+R F A    +  W+
Sbjct: 630 ARQHANERLRRQFAAQANAIGPWI 653



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 47/207 (22%), Positives = 84/207 (40%), Gaps = 17/207 (8%)

Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
            + ++   W+ L+Q        L  E  +L    H  ++F + A   + W   K Q L   
Sbjct: 368  VSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQK 427

Query: 1260 NY-GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
            +Y    L  V+AL RKHE FE DLAA  D+V  +   A+ L +     A ++ ++C ++ 
Sbjct: 428  DYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487

Query: 1319 QAWSSLGKRADQRKAKLGDSHDL--------QRFLSDFRDLMSWINGIRGLVSSDELAKD 1370
              W  LG    +R+  L     L          F        +W+ G    +    +   
Sbjct: 488  DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547

Query: 1371 VTGAEALLERHQEHRTEIDARAGTFQA 1397
            +   ++L+  H++ +  +    G  Q+
Sbjct: 548  IEEIQSLITAHEQFKATLPEADGERQS 574



 Score = 62.0 bits (149), Expect = 7e-09
 Identities = 74/342 (21%), Positives = 148/342 (43%), Gaps = 37/342 (10%)

Query: 357 LNDSYRLQRF--LAD-FRDLTS----WVT-EMKALINADELASDVAGAEALLDRHQEHKG 408
           LN+  RL+R   LA+ FR   S    W   + + L+  D  ++ +    ALL +H+  + 
Sbjct: 390 LNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFES 449

Query: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468
           ++ AH+D  +      Q L    ++ +  V ++   + ++   L  L + RR+  E+   
Sbjct: 450 DLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEK 509

Query: 469 L-----QL---FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL---S 517
           L     QL   F +     +NWM      L +  +  S++ +++L+  HE F+ +L    
Sbjct: 510 LLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEAD 569

Query: 518 AQEEKITALDEFATKLIQ--------NNHYA---MEDVATRRDALLS----RRNALHERA 562
            + + I A+     K+IQ        +N Y+   M+++ T+ D +      R  +L E  
Sbjct: 570 GERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEEL 629

Query: 563 MRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELS 622
            R   Q A+    +QF   ++ +  W+  KM+     + +    L+ ++ + + +E  + 
Sbjct: 630 AR---QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNII 686

Query: 623 ANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
             ++ ID LE   Q + +   +        M  +   W+ LL
Sbjct: 687 NYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLL 728



 Score = 58.5 bits (140), Expect = 8e-08
 Identities = 69/318 (21%), Positives = 134/318 (42%), Gaps = 32/318 (10%)

Query: 480 DNWMSKQEAFLLNEDLGD-SLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH 538
           + W   +E  LL +D    SL  V ALL+KHE FE  L+A ++++  +   A +L + ++
Sbjct: 414 ETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDY 473

Query: 539 YAMEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWV 589
           +   +V  R   +  + + L     +RR  L          D  HL +F + +    +W+
Sbjct: 474 HDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHL-EFAKRAAPFNNWM 532

Query: 590 NEKMKTATDE-AYKDPSNLQGKVQKHQAFEA---ELSANQSRIDALEKAGQKLIDVNHY- 644
              M+   D         +Q  +  H+ F+A   E    +  I A++   +K+I   +  
Sbjct: 533 EGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIR 592

Query: 645 ---AKDEVAARMNEVISLWKKLLEATELKGIKLRE------ANQ--QQQFNRNVEDIELW 693
              +       M+E+ + W K+ +   ++   L+E      AN+  ++QF      I  W
Sbjct: 593 ISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652

Query: 694 LYEVEGHLA--SDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFD 751
           +      +A  S      L +  N  K++   E ++  +++ ID +    +  Q+A  FD
Sbjct: 653 IQNKMEEIARSSIQITGALEDQMNQLKQY---EHNIINYKNNIDKLEGDHQLIQEALVFD 709

Query: 752 AENIKKKQEALVARYEAL 769
            ++     E +   +E L
Sbjct: 710 NKHTNYTMEHIRVGWELL 727



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 65/374 (17%), Positives = 145/374 (38%), Gaps = 28/374 (7%)

Query: 3   PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
           PS  K++       +R +Q    Y  +      R ++LE  +  + F++ A   E W   
Sbjct: 362 PSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLE--HLAEKFRQKASTHETWAYG 419

Query: 63  KLQIASDENYKDP--TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
           K QI   ++Y+    T ++  L+KH+AFE+++ A+   + ++      +    +  +  +
Sbjct: 420 KEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNV 479

Query: 121 RTRLMELHRQWE---LLLEKMR---EKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172
             R  ++  QW+    L +K R   E+  KLL+   Q  +++ +      +W+      +
Sbjct: 480 NDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDL 539

Query: 173 TSEELGQDLEHVEVLQKKFEEFQTDMA---AHEERVNEVNQFAAKLIQEQH----PEEEL 225
               +   +E ++ L    E+F+  +       + +  +     K+IQ  +         
Sbjct: 540 QDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPY 599

Query: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277
                DE+   W ++K L   R   L      Q  N  +    +        WI+ K + 
Sbjct: 600 STVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEE 659

Query: 278 MASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKRE 337
           +A     +   +++  + + +  E ++   ++ +  L  +   +Q++            E
Sbjct: 660 IARSSI-QITGALEDQMNQLKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTME 718

Query: 338 ELITNWEQIRTLAA 351
            +   WE + T  A
Sbjct: 719 HIRVGWELLLTTIA 732



 Score = 42.4 bits (98), Expect = 0.006
 Identities = 47/198 (23%), Positives = 86/198 (43%), Gaps = 17/198 (8%)

Query: 771 EPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKH---- 826
           E ++   ++LA  L L+ + R +     W+  + P        K L   ++  +KH    
Sbjct: 280 ERLMEEYERLASEL-LEWIRRTIP----WLENRTPEKTMQAMQKKLEDFRDYRRKHKPPK 334

Query: 827 --QALQAEIAGHEPRIKA-VTQKGNAMVEEGHFAAEDVKA--KLHELNQKWEALKAKASQ 881
             +  Q EI  +  + K  ++ +   M  EG   ++   A  +L +  + +E       +
Sbjct: 335 VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR 394

Query: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLS 940
           R + LE    A+++   A+  E+W   KE I+   DY         ALL+KHEA  SDL+
Sbjct: 395 RLERLEHL--AEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLA 452

Query: 941 AYGSSIQALREQAQSCRQ 958
           A+   ++ +   AQ   +
Sbjct: 453 AHQDRVEQIAAIAQELNE 470



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 81/428 (18%), Positives = 158/428 (36%), Gaps = 62/428 (14%)

Query: 1235 VQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFE-----------RDLA 1283
            ++ + R A E  EWI      L          ++QA+Q+K E F            ++  
Sbjct: 283  MEEYERLASELLEWIRRTIPWLENRT---PEKTMQAMQKKLEDFRDYRRKHKPPKVQEKC 339

Query: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS----H 1339
             L    N+L +T  R I + P       +  +++  AW  L +     +  L +      
Sbjct: 340  QLEINFNTL-QTKLR-ISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLE 397

Query: 1340 DLQRFLSDFRDLMS----WINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGT 1394
             L+     FR   S    W  G    L+  D  +  +T   ALL +H+   +++ A    
Sbjct: 398  RLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457

Query: 1395 FQAFEQFGQQLLAHGHYASPEIK----------QKLDILDQERADLEKAWVQRRMMLDQC 1444
             +      Q+L    ++ +  +            +L  L Q+R +  +   +    +DQ 
Sbjct: 458  VEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQ- 516

Query: 1445 LELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDF-----------DKA 1493
            L L+ F +      NWM      L       S++ +++LI  HE F              
Sbjct: 517  LHLE-FAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSI 575

Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTL 1553
            + +Q E    +Q++  ++ ++  Y+    +   +E+  +W ++K  +  +   L E    
Sbjct: 576  MAIQNEVEKVIQSYNIRISSSNPYS----TVTMDELRTKWDKVKQLVPIRDQSLQEELAR 631

Query: 1554 Q--------QFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
            Q        QF+   + I  WI  K++  +  S +    ++      K  +H     +  
Sbjct: 632  QHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYK-- 689

Query: 1606 ANADRIRG 1613
             N D++ G
Sbjct: 690  NNIDKLEG 697


>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
          Length = 914

 Score =  280 bits (717), Expect = 1e-74
 Identities = 168/521 (32%), Positives = 283/521 (54%), Gaps = 39/521 (7%)

Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
            +F  KA + E+W   KE  L+  DY    LS ++ LL K E F++ L A  Q+ +  I A
Sbjct: 398  KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRVEQIAA 456

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            +  +L    +  S ++ AR   +  +W  L A +  R++ L   +     ++ L+L +AK
Sbjct: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516

Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA------E 2157
            +A+ FN+W E A EDL D    +++EEI+ L  AH+ F+++L  A  D  +LA      E
Sbjct: 517  RAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA--DKERLAILGIHNE 574

Query: 2158 LDRQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQE 2214
            + + ++++ V    +NPYT  T + +   W ++++++  R+  L +E  RQ+ N++LR++
Sbjct: 575  VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634

Query: 2215 FAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
            F   AN    WIQ     +  G   +E  GTLE QL   ++  + I   + ++ ++E   
Sbjct: 635  FGAQANVIGPWIQTKMEEI--GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692

Query: 2275 AAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFS 2334
              ++EALI DNK+T ++   +   W+QL     R  + +E QI  R+  G+++E + EF 
Sbjct: 693  QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR 752

Query: 2335 MMFKHFDKDKSGRLNHQEFKSCLRSLGYDL---PMVEEGEPD-----------------P 2374
              F HFD+D SG L  +EFK+CL SLGYD+   P  + G  D                  
Sbjct: 753  ASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEA 812

Query: 2375 EFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEEL 2434
            EF  I+  VDPNR G V+ Q ++ FM SRET +  +++++ ++F+ L+ + K Y+T +EL
Sbjct: 813  EFARIMSIVDPNRLGVVTFQAFIDFM-SRETADTDTADQVMASFKILAGD-KNYITMDEL 870

Query: 2435 YQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLF 2475
             + L  +QA+YC++ M PY       +P A DY+ F+ +L+
Sbjct: 871  RRELPPDQAEYCIARMAPYTGPD--SVPGALDYMSFSTALY 909



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 83/382 (21%), Positives = 162/382 (42%), Gaps = 47/382 (12%)

Query: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFT 1925
            R +RL+   E  +F       EAW + K  ++  +DY   TL+ I+ LLKKHEAFE+D  
Sbjct: 388  RLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445

Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE 1979
             H+DRV  +    Q+L + + +   +++++ + +       G ++   + A +R  KL E
Sbjct: 446  AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505

Query: 1980 --NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
              +  +L++  +A    +W+      L+       +  +Q L T  E F A L    +E 
Sbjct: 506  TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565

Query: 2038 IANITALKDQLLAAKHVQSKAIEARHASLM--------------KRWSQLLANSAARKKK 2083
            +A        +L   +  SK ++  H ++                +W  +      R + 
Sbjct: 566  LA--------ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA 617

Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDA 2140
            L E  +  +  E L   F  +A+    W +   E+   ++  +     +++  LR+    
Sbjct: 618  LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ---- 673

Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL----QKIIKEREL 2196
            +  S+ + +   +QL    + I+   +  N +T +TME +   W  L     + I E E 
Sbjct: 674  YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733

Query: 2197 ELQKEQRR---QEENDKLRQEF 2215
            ++     +   QE+ ++ R  F
Sbjct: 734  QILTRDAKGISQEQMNEFRASF 755



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 88/425 (20%), Positives = 167/425 (39%), Gaps = 66/425 (15%)

Query: 357 LNDSYRLQRF--LAD-FRDLTS----WVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408
           LN+  RL+R   LA+ FR   S    W    +A++   D   + ++  +ALL +H+  + 
Sbjct: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFES 442

Query: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468
           ++ AH+D  +      Q L    +Y S  V  +   + ++   L  L + RR+  E+   
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502

Query: 469 L-----QLFYRDTEQV---DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQ 519
           L     QL+    ++    +NWM      L +  +  +++ ++ L   HE F+ +L  A 
Sbjct: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562

Query: 520 EEK--ITALDEFATKLIQNNHYAM---------------------EDVATRRDALLSRRN 556
           +E+  I  +    +K++Q  H  M                       +  RRD  L+  +
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622

Query: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
           A  +   R R         +QF   ++ +  W+  KM+     + +    L+ ++   + 
Sbjct: 623 ARQQHNERLR---------KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ 673

Query: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLE----------- 665
           +E  +   + +ID LE   Q + +   +        M  +   W++LL            
Sbjct: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733

Query: 666 ---ATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHA 721
                + KGI   + N+ +  FN    D    L   E        G D+ N  + QKK  
Sbjct: 734 QILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGN--DPQKKTG 791

Query: 722 LLEAD 726
           +++ D
Sbjct: 792 MMDTD 796



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 50/250 (20%), Positives = 110/250 (44%), Gaps = 14/250 (5%)

Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
            ++R   LD   E   F +     E W   +EA L  +D +  +L  ++AL+KKHE F+  
Sbjct: 386  IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443

Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKA------QMIEKRSKL 1547
            +   ++++  + A A +L    +Y    +++R  ++ D+W  L A      + +E+  KL
Sbjct: 444  LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503

Query: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
             E+  Q   ++++       W+   ++   D ++   T  ++  L + H++ +A   +  
Sbjct: 504  LETIDQLYLEYAKRAAPFNNWMEGAMEDLQD-TFIVHTIEEIQGLTTAHEQFKATLPDAD 562

Query: 1606 ANADRIRGVIDMGNSLIE--RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
                 I G+ +  + +++      AG+          +  +W  + Q    + Q L E +
Sbjct: 563  KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622

Query: 1664 KQQNFNTGIK 1673
             +Q  N  ++
Sbjct: 623  ARQQHNERLR 632



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 9/137 (6%)

Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
            + ++N  W  L+Q        L  E  +L    H  ++F + A   + W + K   L   
Sbjct: 361  VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420

Query: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
            +Y    L+ ++AL +KHE FE DLAA  D+V  +   A+ L +     +  +  +C ++ 
Sbjct: 421  DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480

Query: 1319 QAWSSLGKRADQRKAKL 1335
              W +LG    +R+  L
Sbjct: 481  DQWDNLGALTQKRREAL 497



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 84/389 (21%), Positives = 154/389 (39%), Gaps = 44/389 (11%)

Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
            Q++E   KL  S  L+   R +  +E  + E    A  +  +D  +    + L K  K Q
Sbjct: 274  QLMEDYEKLA-SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY---RRLHKPPKVQ 329

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657
              + +L  N + ++  + + N    R A   SE  +   ++ + + W  L Q +   +  
Sbjct: 330  E-KCQLEINFNTLQTKLRLSN----RPAFMPSEGRM---VSDINNAWGCLEQVEKGYEEW 381

Query: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLE 1709
             L E  + +  +   + F       + W    EA+L  +DY    L+ +  LLKKH+  E
Sbjct: 382  LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441

Query: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769
            +D++AH+DR++ + + A  L     +D+  V  +   I  ++  + ++   RR  L  + 
Sbjct: 442  SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501

Query: 1770 RLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821
            +L +    +  E         +W++     +        +  +Q L   H++ +A L   
Sbjct: 502  KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561

Query: 1822 EP---AIQGVLDTGKKLSDD---NTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEES 1874
            +    AI G+ +   K+      N  G         Q +   W  ++QL   R Q L E 
Sbjct: 562  DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621

Query: 1875 LEYQ--------QFVANVEEEEAWINEKM 1895
               Q        QF A       WI  KM
Sbjct: 622  HARQQHNERLRKQFGAQANVIGPWIQTKM 650



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 25/235 (10%)

Query: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE 207
           Q +  Y +   D+++WI  +        + ++  H   +Q+K E+F+     H+  +V E
Sbjct: 274 QLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHA--MQQKLEDFRDYRRLHKPPKVQE 330

Query: 208 -------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRLKGLA----------LQRQG 249
                   N    KL     P     + +   ++N AW  L+ +           ++R  
Sbjct: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390

Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALE 308
           +L   AE  R    + E  +W   KE ++   D+    L+ ++ALL+KHE  E DLAA +
Sbjct: 391 RLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448

Query: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
           D+V+ + A A  L +     +  +  + +++   W+ +  L  +R   L  + +L
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 68/347 (19%), Positives = 143/347 (41%), Gaps = 31/347 (8%)

Query: 32  LSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPT--NLQGKLQKHQAFE 89
           L+ +RR +  D    +F Q+ A   E W   K  +   ++Y+  T   ++  L+KH+AFE
Sbjct: 383 LNEIRRLERLDHLAEKFRQK-ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441

Query: 90  AEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE---LLLEKMR---EKGI 143
           +++ A+   + ++      +    ++ S ++  R  ++  QW+    L +K R   E+  
Sbjct: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501

Query: 144 KLLQA--QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMA-A 200
           KLL+   Q  ++Y +      +W+      +    +   +E ++ L    E+F+  +  A
Sbjct: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561

Query: 201 HEER--VNEVNQFAAKLIQEQHPE----EELIKTKQDEVNAAWQRLKGLALQRQGKLFGA 254
            +ER  +  ++   +K++Q  H               E+N  W  ++ L  +R   L   
Sbjct: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621

Query: 255 AEVQRFNRDVDETIS--------WIKEKEQLMA--SDDFGRDLASVQALLRKHEGLERDL 304
              Q+ N  + +           WI+ K + +   S +    L    + LR++   E+ +
Sbjct: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQY---EKSI 678

Query: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
              + K+  L  +   +Q++            E +   WEQ+ T  A
Sbjct: 679 VNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 57/286 (19%), Positives = 118/286 (41%), Gaps = 31/286 (10%)

Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
           ++F +     E W    E  L   DY    L+ ++ L KKH   E+D+AAHQDR++ I  
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456

Query: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQLFRDV 793
            A++  +  ++D+ ++  + + +  +++ L      +   + R +KL ++  + QL+ + 
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET--IDQLYLEY 514

Query: 794 EDE----ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR---IKAVTQK 846
                    W+         T     +  +Q L   H+  +A +   +     I  +  +
Sbjct: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE 574

Query: 847 GNAMVEEGHFAAEDVKAKL----HELNQKWEALKAKASQRRQDLEDSLQAQ--------Q 894
            + +V+  H               E+N KW+ ++    +R Q L +    Q        Q
Sbjct: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634

Query: 895 YFADANEAESWMREKEPIVGSTD---YGKDEDSAEALLKKHEALMS 937
           + A AN    W++ K   +G      +G  ED    L +  +++++
Sbjct: 635 FGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVN 680



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 65/317 (20%), Positives = 127/317 (40%), Gaps = 34/317 (10%)

Query: 482 WMSKQEAFLLNEDLGDS-LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
           W   +EA L  +D   + L  ++ALLKKHE FE  L+A ++++  +   A +L + ++Y 
Sbjct: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468

Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWVNE 591
              V  R   +  + + L     +RR  L          D  +L ++ + +    +W+  
Sbjct: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYL-EYAKRAAPFNNWMEG 527

Query: 592 KMKTATDE-AYKDPSNLQGKVQKHQAFEAEL-SANQSRIDAL--EKAGQKLIDVNHY--- 644
            M+   D         +QG    H+ F+A L  A++ R+  L       K++   H    
Sbjct: 528 AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA 587

Query: 645 -AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVED--------IELWL- 694
                      E+   W  + +    +   L E + +QQ N  +          I  W+ 
Sbjct: 588 GTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQ 647

Query: 695 --YEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDA 752
              E  G ++ + +G     + +L++     E  +  ++ +ID +    +  Q+A  FD 
Sbjct: 648 TKMEEIGRISIEMHGTLEDQLSHLRQ----YEKSIVNYKPKIDQLEGDHQLIQEALIFDN 703

Query: 753 ENIKKKQEALVARYEAL 769
           ++     E +   +E L
Sbjct: 704 KHTNYTMEHIRVGWEQL 720



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 65/326 (19%), Positives = 136/326 (41%), Gaps = 54/326 (16%)

Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093
            N L+ +  ++ R   + ++ R+  +  +    ++QVE+ Y   L    +R   L+   +K
Sbjct: 339  NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398

Query: 1094 FMLFREANELQQWINEKEAALTSEEVG-ADLEQVEVLQKKFDDFQKDLKANESRLKDINK 1152
            F   ++A+  + W + KEA L  ++   A L +++ L KK + F+ DL A++ R++ I  
Sbjct: 399  FR--QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456

Query: 1153 VAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELN 1212
            +A++L              + + Y             SP  +AR            +++ 
Sbjct: 457  IAQELN-------------ELDYYD------------SPSVNARC-----------QKIC 480

Query: 1213 ERWRSLQQLAEERSQLLGSAHEVQR--------FHRDADETKEWIEEKNQALNTDNYGHD 1264
            ++W +L  L ++R + L    ++          + + A     W+E   + L      H 
Sbjct: 481  DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540

Query: 1265 LASVQALQRKHEGFERDLA-ALGDKVNSLG--ETAERLIQSHPESAEDLQEKCT----EL 1317
            +  +Q L   HE F+  L  A  +++  LG      +++Q++  +        T    E+
Sbjct: 541  IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600

Query: 1318 NQAWSSLGKRADQRKAKLGDSHDLQR 1343
            N  W  + +   +R   L + H  Q+
Sbjct: 601  NGKWDHVRQLVPRRDQALTEEHARQQ 626



 Score = 48.5 bits (114), Expect = 8e-05
 Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 8/114 (7%)

Query: 776 RKQKLADSLRLQQLFRDV--EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEI 833
           R   LA+  R +    +   + +E  +R+K+   A+ +       ++ LLKKH+A ++++
Sbjct: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE------IKALLKKHEAFESDL 444

Query: 834 AGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
           A H+ R++ +      + E  ++ +  V A+  ++  +W+ L A   +RR+ LE
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 55/290 (18%), Positives = 115/290 (39%), Gaps = 32/290 (11%)

Query: 1315 TELNQAWSSLGK-RADQRKAKLGDSHDLQRF---LSDFRDLMS----WINGIRGLV-SSD 1365
            +++N AW  L +      +  L +   L+R       FR   S    W +G   ++   D
Sbjct: 362  SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKD 421

Query: 1366 ELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQ 1425
                 ++  +ALL++H+   +++ A     +      Q+L    +Y SP +  +   +  
Sbjct: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481

Query: 1426 ERADLEKAWVQRRMMLDQCLEL-----QLFHRDCEQA---ENWMAAREAFLNTEDKGDSL 1477
            +  +L     +RR  L++  +L     QL+    ++A    NWM      L       ++
Sbjct: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541

Query: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAAL----------QAFADQLIAAGHY---AKGDIS 1523
            + ++ L   HE F   + +  +E++A L          Q +   +     Y      +I+
Sbjct: 542  EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601

Query: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQ 1572
             + + V     R    + E+ ++   ++ L +QF    + I  WI  K++
Sbjct: 602  GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKME 651



 Score = 38.5 bits (88), Expect = 0.083
 Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)

Query: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA-EALLKKHEALMSDLS 940
           RR +  D L A+++   A+  E+W   KE ++   DY     S  +ALLKKHEA  SDL+
Sbjct: 387 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445

Query: 941 AYGSSIQALREQAQSCRQ 958
           A+   ++ +   AQ   +
Sbjct: 446 AHQDRVEQIAAIAQELNE 463


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  278 bits (711), Expect = 5e-74
 Identities = 415/1966 (21%), Positives = 824/1966 (41%), Gaps = 178/1966 (9%)

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASET--IRTRLMELHRQ 130
            +D   LQ + +  +AF  +++A   +    ++T  +M++    + +   I+  L  L +Q
Sbjct: 3145 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 3204

Query: 131  WELLLEKM--REKGIK--LLQAQKLVQYLRECEDVMDWINDKEAI-----VTSEELGQDL 181
               LL++   RE+ ++  + + ++    L+E   ++    + E       + +E + Q L
Sbjct: 3205 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 3264

Query: 182  EHVEVLQKKFEEFQTDMAAHEERVNEVNQ----FAAKLIQEQHPEEELIKTKQDEVNAAW 237
               +V QK  EE +  +   ++ VN + Q     AAK    Q  E +L     D+VNA W
Sbjct: 3265 NMFKVFQK--EEIEP-LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL-----DDVNARW 3316

Query: 238  QRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLR 295
            + L     QR  +L  A     RF   ++  +SW+ + E+L+A+      +   V+A ++
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3376

Query: 296  KHEGLERDLAALEDKVKALCAEADRLQQS-HPLSATQIQVKREELITNWEQIRTLAAERH 354
            + + L+R L   +  V+ +  E +++  +  P    +I  +   L + WE +   A  R+
Sbjct: 3377 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3436

Query: 355  ARLND-SYRLQRFLADFRDLTSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDA 412
             +L   S   Q+F      L  W+T + K L+N + + +  +  E  + +H+  + +I  
Sbjct: 3437 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3496

Query: 413  HEDSFKSADESGQAL-LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-DLQ 470
            H      A   GQ+L + +     D V+ KL         + E    R +  +Q + + +
Sbjct: 3497 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3556

Query: 471  LFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLSAQEEKITAL 526
            +F  D  ++ NW+++    L    + D   S E L K+  +     E  L  ++    AL
Sbjct: 3557 IFGEDEVELMNWLNEVHDKLSKLSVQDY--STEGLWKQQSELRVLQEDILLRKQNVDQAL 3614

Query: 527  DEFATKLIQNNHYAMEDVATRRDALLSRRNALHE------RAMRRRAQLADSFHLQQFFR 580
                  L Q     +  +  + +A+ +R   + +      + + +  QLA   H      
Sbjct: 3615 LNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTH--- 3671

Query: 581  DSDELKSWVNE---KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
              +EL +W+++   ++ +   +  K     Q +++  +  + E   N++ +D+L +    
Sbjct: 3672 --EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNEVSSA 3728

Query: 638  LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN--QQQQFNRNVEDIELWLY 695
            L+++  +   E   +M    +   +L+  T  + ++  +A   + QQF++  +    W+ 
Sbjct: 3729 LLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT 3788

Query: 696  EVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA-GHFD 751
            E E  L S       +D T+ Q   +K   +E  +  H+D ID +     +   A    +
Sbjct: 3789 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHKIMTACSEEE 3846

Query: 752  AENIKKKQEALVARYEALKEPMVARKQKL--ADSLRLQQLFRDVEDEETWIREKEPIAAS 809
             +++KKK + ++  Y+ + +    R  +L  A SL + Q +   E+   W+ E + I + 
Sbjct: 3847 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETYEELWPWLTETQSIISQ 3905

Query: 810  TNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
                  +   ++   ++H+ L+  IA H+P I  + + G  ++E        ++ K    
Sbjct: 3906 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA 3965

Query: 869  NQKWEALKAKASQRRQDLEDSLQAQQYFADANEA--ESWMREKEPIVGSTDYGKDEDSAE 926
            +  +  +K    +R   L++++     F D  +   ES  R  E +        + +  +
Sbjct: 3966 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4025

Query: 927  ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ----EKS 982
              + +++ +  D+       + L+++ +    +   TD +   + V    D      E  
Sbjct: 4026 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4085

Query: 983  PREVTMKKGDILTLLNSTNKDWWK-----VEVNDRQGFVPAAYVKKLDPA----QSASRE 1033
               V  ++  +L ++    K W       V + D Q F+       +DP+    Q  + E
Sbjct: 4086 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4145

Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVS------LRMKQVEEL---YHSLLELGEKRK 1084
             + EE   +   QE++D    +  E  +        +  K ++EL   + SL +  + R 
Sbjct: 4146 TIREEIDGL---QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4202

Query: 1085 GMLEKSCKKFMLFREANE-LQQWINEKEAALTS-EEVGADLEQVEVLQKKFDDFQKDLKA 1142
              LE++ +  + +++  + +  W++     L S   +G DLE V+   ++   F+ +   
Sbjct: 4203 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4262

Query: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
             +  ++ +N  AE      L+ ++V              +E+D              HTV
Sbjct: 4263 QQIEMERLNHQAE------LLLKKVT-------------EESDK-------------HTV 4290

Query: 1203 ATFNSIKELNERWRSLQQ-LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN- 1260
               + + EL   W SL++ +   + +L G+   + +F    DE   W+      L+    
Sbjct: 4291 Q--DPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4348

Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTELNQ 1319
             G D  +++    KH   + D+ A    V ++ +    LI+S   E A +LQ K   LNQ
Sbjct: 4349 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4408

Query: 1320 AWSSLGKRADQRKAKL-GDSHDLQRFLSDFRDLMSWINGI-RGLVSSDELAKDVTGAEAL 1377
             W ++ ++ +QRK +L G     + F  +  DL  W+    R L++S  L      A+  
Sbjct: 4409 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4468

Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQ 1436
            L  H E     +A+  T+++  Q GQQ+LA     A   I Q ++ L ++   +E    +
Sbjct: 4469 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4528

Query: 1437 RRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAI 1494
            R+  L++ L L + FH   +   NW+   E  LN   +    LD+V   I +H+ F   +
Sbjct: 4529 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4588

Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRN---EVLDRWRRLKAQMIEKRSKLGESQ 1551
            N   E+I  L      L       K D+   +N    V  RW ++  +++E+   L +++
Sbjct: 4589 NSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4646

Query: 1552 T-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
               +QF     ++  W+  SEK   +  E   DP  I+    L++H++ Q      H+  
Sbjct: 4647 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ--LAQHKEFQKSLGAKHSVY 4704

Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK-QQN 1667
            D        G SL E+ + A     +   L+ L D+W  +  KS E+  KL+EA      
Sbjct: 4705 DTTNRT---GRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4761

Query: 1668 FNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
            F   ++    WL  VE  LA +   +G D+  V NL+  H+  + ++      ++ L   
Sbjct: 4762 FTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4820

Query: 1726 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR--------LHQFFRD 1777
            A  L+  S  D+S VK +   ++ R++ + +++ S++ +L  + R        +H     
Sbjct: 4821 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4880

Query: 1778 MDDEESWIKEKKLLVGSEDYGRDLTGV-QNLRKKHKRLEAELAAHEPAIQGVL-----DT 1831
            + + E  ++   +L   ED  R L    +   KK +   AEL         VL     D+
Sbjct: 4881 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 4940

Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA---ARGQRLEESLEYQQFVANVEEEE 1888
               +    TI +   ++ LA   +H + L    A   A+ + LE  L + Q         
Sbjct: 4941 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQ--------- 4991

Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
             W    +T    E     +  ++ L+ +H+ F  + T  +  V+ V
Sbjct: 4992 -WAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5036



 Score =  265 bits (676), Expect = 5e-70
 Identities = 503/2529 (19%), Positives = 1024/2529 (40%), Gaps = 298/2529 (11%)

Query: 49   FQRDAEELEKWIQEKLQIASDENYKDPTN-----LQGKLQKHQAFEAEVQANSGAIVK-L 102
            FQ+ + + + W+  K +   ++N   P +     L+  ++ H+ F   + A S    K +
Sbjct: 2794 FQQMSRDFQAWLDTKKE---EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2850

Query: 103  DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA-QKLVQYLRECEDV 161
             E  NL++         ++ +L  +   W+   ++++E+  KL ++ +K ++Y  + E +
Sbjct: 2851 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2910

Query: 162  MDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
              WI+  +  +   +   D    E    K +  Q +M  H   V  +N  A  L+     
Sbjct: 2911 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2970

Query: 222  EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE-----KEQ 276
            ++E++    DE  +  Q++  +  Q   K F    + +  ++  E     K      KEQ
Sbjct: 2971 DKEVVT---DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQ 3027

Query: 277  LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
            L   D  G    S    L   +  ++ L AL+ +V      A RL Q   + A+  +   
Sbjct: 3028 LDIHDSLGSQAYS-NKYLTMLQTQQKSLQALKHQVDL----AKRLAQDLVVEASDSKGTS 3082

Query: 337  EELITNWEQIRTLAAERHARLNDSY---------RLQ---RFLADFRDLTSWVTEMKALI 384
            + L+    Q+ T+A E H+ L+            +LQ    F    R++ S   E    +
Sbjct: 3083 DVLL----QVETIAQE-HSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDEL 3137

Query: 385  NADELASDVAGAEALLDRHQEHKG---EIDAHEDSFKSADESGQALLAAGHYASDEV--R 439
              D +A     AE L  + +  K    +++A   S  +A+++ + +LA    + D V  +
Sbjct: 3138 --DSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3195

Query: 440  EKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDTEQVDNWMSKQEAFLLNED-LGD 497
              L  LS++   LL+  + R +Q E  +  L+ FY   ++    + K E    ++  +G 
Sbjct: 3196 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 3255

Query: 498  SLDSVEALLKKHEDFEKS----LSAQEEKITALDEFATKLIQNNHYAMEDVATRR----- 548
              +++   L   + F+K     L  +++ +  L +    LIQ+   A +  +T+      
Sbjct: 3256 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ---GLIQS---AAKSTSTQGLEHDL 3309

Query: 549  DALLSRRNALHERAMRRRAQLADSF-HLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN- 606
            D + +R   L+++  +R AQL ++  H  +F    + L SW+ +  +   ++  K PS  
Sbjct: 3310 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ--KPPSAE 3367

Query: 607  ---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA-KDEVAARMNEVISLWKK 662
               ++ ++Q+ +  +  L   +S ++ +++ G+K+      A K ++  +++ + S W+ 
Sbjct: 3368 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3427

Query: 663  LLEATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLAS-DDYGKDLTNVQNLQKKH 720
            LL   E +  +L   +   QQF+  +E +  WL  +E  L + +  G   + ++    +H
Sbjct: 3428 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3487

Query: 721  ALLEADVAAHQDRI-DGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
              LE D+  H   +   ++I       +   D + ++ K +     Y  ++E   +R + 
Sbjct: 3488 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3547

Query: 780  LADSLRLQQLFRDVEDE-ETWIRE-KEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHE 837
            L  +L   ++F + E E   W+ E  + ++  + +     G+     + + LQ +I   +
Sbjct: 3548 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3607

Query: 838  PRIKAVTQKGNAMVEEGHFAAEDV---KAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQ 893
              +      G  ++++     ++V   + KL  +  +++ +   ++   + LE +LQ A+
Sbjct: 3608 QNVDQALLNGLELLKQT--TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3665

Query: 894  QYFADANEAESWMR--EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
            +  +   E  +W+   E E +   T   K E++++A ++  E L  +     + + +L E
Sbjct: 3666 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNE 3724

Query: 952  QAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVND 1011
               S   ++ P     G E ++A              +  +   L++ T     KVE  D
Sbjct: 3725 -VSSALLELVPWRAREGLEKMVA--------------EDNERYRLVSDTITQ--KVEEID 3767

Query: 1012 RQGFVPAAYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITK------------ 1057
                    + +  D   S     E  L   G I L Q+Q   Q ++ K            
Sbjct: 3768 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3827

Query: 1058 ------------------EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
                              E  S+  ++ +V + Y ++ ++  +R   LE++      F E
Sbjct: 3828 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3887

Query: 1100 A-NELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL 1157
               EL  W+ E ++ ++     A + E +   Q++    ++ +  ++  +  +NK    L
Sbjct: 3888 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3947

Query: 1158 ----ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNE 1213
                  EG   +E + V    +Y  +  D              +    VA   +I +  +
Sbjct: 3948 LELSPGEGFSIQE-KYVAADTLYSQIKED--------------VKKRAVALDEAISQSTQ 3992

Query: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
                + Q+ E   +++    +      + ++ KE I E        N   D+  +Q L  
Sbjct: 3993 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK------NVSVDMEKLQPLYE 4046

Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
                    L   G+++ +     ++ I     SA+ +Q+K  ++   W ++    ++R+A
Sbjct: 4047 T-------LKQRGEEMIARSGGTDKDI-----SAKAVQDKLDQMVFIWENIHTLVEEREA 4094

Query: 1334 KLGDSHDL-QRFLSDFRDLMSWINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDAR 1391
            KL D  +L ++F  D   L+  I   +  +   ++   D +  +   E  +  R EID  
Sbjct: 4095 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 4154

Query: 1392 AGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
                      G +L+A  G    P +K+ +D L+     L KAW  R   L++ ++  + 
Sbjct: 4155 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 4214

Query: 1451 HRDCEQAE-NWM-AAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508
            ++D  QA  +W+  A     +    G  L++V+  I++ + F      Q+ ++  L   A
Sbjct: 4215 YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQA 4274

Query: 1509 DQLI--AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEA 1565
            + L+        K  +     E+   W  L+ ++I ++ KL G    L QF   +DE+ A
Sbjct: 4275 ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 4334

Query: 1566 WIS--EKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1623
            W++  E L +       DP  I++        KH   + ++ A+   +  V   GN LIE
Sbjct: 4335 WLTHTEGLLSEQKPVGGDPKAIEIELA-----KHHVLQNDVLAHQSTVEAVNKAGNDLIE 4389

Query: 1624 RGACAGSEDA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSE 1681
              + AG E + ++ +L  L  +WQ +++K+ ++ Q+L  A +Q + F+  I+D   WL++
Sbjct: 4390 --SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4447

Query: 1682 VEA-LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDT-SQ 1739
             E  LLAS+  G    +    L  H  + A   A E+  K L  +   ++        + 
Sbjct: 4448 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4507

Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLH-QFFRDMDDEESWIK--EKKLLVGSED 1796
            +    + +  +++ +++    R+ KL E+  L  +F   + D  +W+   E+ L V S  
Sbjct: 4508 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4567

Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE---IQQRLAQF 1853
                L  V     +HK    E+ +H   I  +  TG  L   +   K++   I+  L   
Sbjct: 4568 -SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISV 4624

Query: 1854 VEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQ 1911
               W+++ Q    RG+ L+++ +  +QF     +   W+ E    + SE +  +    I+
Sbjct: 4625 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4684

Query: 1912 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENIS--SKMKGLNGKVSDLEKA 1969
              L +H+ F+          +     G+ L +K +  ++N+     +  L  K   +   
Sbjct: 4685 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4744

Query: 1970 AAQRKAKLDENSAFL-QFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTKQETF 2026
            + +R+ KL+E   F  QF      +  W+   E  L  D   +G D+  V  L+   + F
Sbjct: 4745 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAF 4803

Query: 2027 DAGLQAFQQEGIANITALKD---QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKK 2083
               L     +  +++ ALK    +L+      S  ++ +   L  RW  + A S +++ +
Sbjct: 4804 QKELG----KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4859

Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLT-DPVRCNSLEEIKALREAHDAFR 2142
            L   ++  R+ E+    F     A   W   AE+ L    V  +  + ++ L + H  F 
Sbjct: 4860 L---EAALRQAEE----FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4912

Query: 2143 SSLSSAQADFNQLAELDRQIKSFRVASNPYT---WFTM------EALEETWRNLQK---- 2189
              L   +A+ N+   +   + +     +  T   W T+      E L    ++ Q+    
Sbjct: 4913 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4972

Query: 2190 ----IIKERELELQKEQRRQEEN---DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEE 2242
                I K+  LE      +  E    DK ++   Q        I E +T++ +   M  +
Sbjct: 4973 LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEE---MTRK 5029

Query: 2243 SGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVG-------- 2294
               ++   +  KR+  +  +++S +  + D G A  +     + Y   S           
Sbjct: 5030 QPDVDKVTKTYKRRAADPSSLQSHIPVL-DKGRAGRKRFPASSLYPSGSQTQIETKNPRV 5088

Query: 2295 --LAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM---------------- 2336
              L  +W Q+  L +  +  L   +          E L+EF+                  
Sbjct: 5089 NLLVSKWQQVWLLALERRRKLNDALDRL-------EELREFANFDFDIWRKKYMRWMNHK 5141

Query: 2337 -------FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2389
                   F+  DKD+ G++  QEF   + S  +    +       E  A+ D  D + DG
Sbjct: 5142 KSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL-------EMSAVADIFDRDGDG 5194

Query: 2390 HVSLQEYMA 2398
            ++   E++A
Sbjct: 5195 YIDYYEFVA 5203



 Score =  233 bits (594), Expect = 2e-60
 Identities = 446/2453 (18%), Positives = 976/2453 (39%), Gaps = 266/2453 (10%)

Query: 21   QVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIAS--DENYKDPTN 77
            ++  ++    +L+  R+QKLE+S      FQ    +L++W+ EK  + S       DP  
Sbjct: 2544 EIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2603

Query: 78   LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTRLMELHRQWELL 134
            L  + Q+ Q    E         +L   G  ++S   E       ++ +L  + ++W+ L
Sbjct: 2604 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2663

Query: 135  LEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSEE-LGQDLEHVE 185
              ++ ++        +K  Q Q L++ L +   D+ + ++   A+ T  + + Q LE  +
Sbjct: 2664 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2723

Query: 186  VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNA---AWQRLKG 242
             ++++ ++ +  +   +    +++     L++E++ + EL +  +  + +     Q+ + 
Sbjct: 2724 KMKQEIQQEKKQIKVAQALCEDLSA----LVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2779

Query: 243  LALQRQGKLFGAAEVQRFNRDVDETISWIK-EKEQLMASDDFGRDLASVQALLRKHEGLE 301
                 Q     + + Q+ +RD     +W+  +KE+   S      L  +++L++ H+   
Sbjct: 2780 HVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2836

Query: 302  RDLAALEDKVKALCAEADRL---QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLN 358
            + L A     +   AE + L    Q    +A Q+Q+    + TNW+       ER  +L 
Sbjct: 2837 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT--IKTNWDTFNKQVKERENKLK 2894

Query: 359  DSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSF 417
            +S  +  ++      L  W+ + +  +   +   D A  E  + + +  + E+D H    
Sbjct: 2895 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2954

Query: 418  KSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQ---CMD-LQLFY 473
            +  + +  +LL+      +       V+++E  +L++  ++  +Q      C++ +   +
Sbjct: 2955 ELLNNTANSLLSVCEIDKE-------VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3007

Query: 474  RDTEQVDNWMSKQEAFLLNE-DLGDSLDSVEALLKKH----EDFEKSLSAQEEKITALDE 528
            ++ ++V     +Q      + D+ DSL S +A   K+    +  +KSL A + ++     
Sbjct: 3008 KEFQEVSKESKRQLQCAKEQLDIHDSLGS-QAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3066

Query: 529  FATKLI--QNNHYAMEDVATRRDALLSRRNALHERAMRR----RAQLADSFHLQQFFRDS 582
             A  L+   ++     DV  + + +    + L ++   +      +L    H Q   R+ 
Sbjct: 3067 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3126

Query: 583  DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVN 642
                +  ++++ +      +D   LQ + +  +AF  +L A  +  D   K  + ++   
Sbjct: 3127 FSQFAEFDDELDSMAPVG-RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATE 3185

Query: 643  HYAKDEVAARMN-EVISLW-KKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEG 699
              + D V  + + E +S    KLL+  + +  ++    ++ ++F   +++  + L + E 
Sbjct: 3186 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3245

Query: 700  HLASDD-YGKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQF--QDAGHFDAENI 755
            H  S    G +   + Q L       + ++   Q +   +    +      A     + +
Sbjct: 3246 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3305

Query: 756  KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-VEDEETWIREKEPIAASTNR-G 813
            +   + + AR++ L + +  R  +L ++L     F+D +E   +W+ + E + A+     
Sbjct: 3306 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS 3365

Query: 814  KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQK 871
             +   V+  +++ + LQ  +   +  ++ + ++G  +       A+ VK   +L  L+ +
Sbjct: 3366 AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSR 3424

Query: 872  WEALKAKASQRRQDLED-SLQAQQYFADANEAESWMREKEP-IVGSTDYGKDEDSAEALL 929
            WEAL  KA  R + LE  S+ AQQ+         W+   E  +V     G      E  +
Sbjct: 3425 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3484

Query: 930  KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMK 989
             +H+AL  D+  +   +     QA S  Q +        K++V +  D+ +    E+  K
Sbjct: 3485 AQHKALEDDIINHNKHLH----QAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3540

Query: 990  KGDILTLLNST-------NKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
                  LL           +D      W  EV+D+        + KL   Q  S E L +
Sbjct: 3541 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK--------LSKLS-VQDYSTEGLWK 3591

Query: 1038 EQGS-------IALRQEQID----NQTRITKEAGS-----VSLRMKQVEELYHSLLELGE 1081
            +Q         I LR++ +D    N   + K+        +  +++ ++  Y  + +L  
Sbjct: 3592 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3651

Query: 1082 KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV----GADLEQVEVLQKKFDDF 1136
                 LE++ +        +E L  W+++ E  L S E     G +  Q ++  K   + 
Sbjct: 3652 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK---EL 3708

Query: 1137 QKDLKANESRLKDINK--------------------VAEDLESEGLMAEEV-QAVQQQEV 1175
            +K+ K N++ L  +N+                    VAED E   L+++ + Q V++ + 
Sbjct: 3709 KKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDA 3768

Query: 1176 YGMMPRD-------------ETDSKTAS--------PWKSARLMV--------------- 1199
              +  +              ET+ K  S           SA+L V               
Sbjct: 3769 AILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3828

Query: 1200 -------HTVATFNSIKELNERWRSLQQL-----------AEERSQLLGSAHEVQRFHRD 1241
                   H + T  S +E     + L ++           +E   QL  +   V +F   
Sbjct: 3829 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3888

Query: 1242 ADETKEWIEEKNQALNT-DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI 1300
             +E   W+ E    ++       +  +++  Q +H      +A     ++ + +T  +L+
Sbjct: 3889 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3948

Query: 1301 QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRD--LMSWINGI 1358
            +  P     +QEK    +  +S + +   +R   L ++        D  D  L S    +
Sbjct: 3949 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4008

Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
              L     ++ +V   +  +  ++    +++     ++  +Q G++++A       +I  
Sbjct: 4009 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4068

Query: 1419 KL--DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN-WMAAREAFLNTEDKGD 1475
            K   D LDQ    +   W     ++++  E +L     E AE  W       +  +D  D
Sbjct: 4069 KAVQDKLDQ----MVFIWENIHTLVEE-REAKLLDV-MELAEKFWCDHMSLIVTIKDTQD 4122

Query: 1476 SLDSVE------ALIKKHEDFDKAIN-----VQEEKIAALQAFADQLIAAGHYAKGDISS 1524
             +  +E      +++K+ ++  + I      +QEE    +   ++ + A G   K  +  
Sbjct: 4123 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4182

Query: 1525 RRNEVLDRWRRLKAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS---EKLQTASDESYK 1580
              +E+   W  L     ++  KL E+ Q   Q+   +  +  W+     KL + S     
Sbjct: 4183 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----- 4237

Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
             P    L  +  + ++ + F++E +     +  +      L+++      +  V+  L  
Sbjct: 4238 -PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 4296

Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQN-FNTGIKDFDFWLSEVEALLASED-YGKDLASV 1698
            L   W  L ++   +  KL+ A      F   + +   WL+  E LL+ +   G D  ++
Sbjct: 4297 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4356

Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGRFQKIKSM 1757
               L KH +L+ D+ AH+  ++ +N   + L+ SSA +  S +++K + +N R+Q +   
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4416

Query: 1758 AASRRAKLNESHRLHQFFR-DMDDEESWIK--EKKLLVGSEDYGRDLTGVQNLRKKHKRL 1814
               R+ +L+ + R  + F  +++D + W+   E+ LL      G   T  + L   H  +
Sbjct: 4417 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV-HMEV 4475

Query: 1815 EAELAAHEPAIQGVLDTGKK-LSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
             A   A E   + ++  G++ L+      +  I Q +    E W+ ++     R  +LEE
Sbjct: 4476 CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4535

Query: 1874 SLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931
            +L    +F  ++++   W+ + + TL  +      L  +   + +H+ F  +   H++++
Sbjct: 4536 ALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQI 4595

Query: 1932 NDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWK 1989
             ++   G  L   +   +   I + +  +  +   + +   +R   LD+      QF+  
Sbjct: 4596 IELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEA 4655

Query: 1990 ADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT-----A 2043
               +  W+ E E SL ++ +   D   ++T L + + F   L A  +  + + T     +
Sbjct: 4656 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA--KHSVYDTTNRTGRS 4713

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            LK++   A    +  ++   + L  +W  +   S  R+ KL EA     +  D       
Sbjct: 4714 LKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL----- 4766

Query: 2104 KASAFNSWFENAEEDLTD--PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
               A   W    E  L +  PV    ++ +  L + H AF+  L    +    L    R+
Sbjct: 4767 --QALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4823

Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANA 2221
            +       + +    M+ L   W  +  +   ++  L+   R+ EE       F    +A
Sbjct: 4824 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEE-------FHSVVHA 4876

Query: 2222 FHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
              +W+ E    L     + ++   L + ++  K   +++   R++L K   +G
Sbjct: 4877 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMG 4929



 Score =  226 bits (576), Expect = 2e-58
 Identities = 433/2280 (18%), Positives = 920/2280 (40%), Gaps = 246/2280 (10%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF-FQRDAEELEKWIQEKLQIASDENY- 72
            +Q +   +   +  F +    R  KL++S      ++   E L  WI +      +  + 
Sbjct: 2868 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2927

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
             DP   +  + K ++ + E+  + G +  L+ T N ++S      E +      L ++ +
Sbjct: 2928 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2987

Query: 133  LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND-----KEAIVTSEELGQDL---EHV 184
            ++ E++  K   L   + + Q  +E ++V           KE +   + LG      +++
Sbjct: 2988 MVTEQLHSKKFCL---ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3044

Query: 185  EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL------IKTKQDEVNAAWQ 238
             +LQ +    Q  + A + +V+   + A  L+ E    +        ++T   E +   Q
Sbjct: 3045 TMLQTQ----QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3100

Query: 239  RLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ------- 291
            ++       + KL G    Q   R++    +   ++   MA    GRD  ++Q       
Sbjct: 3101 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP--VGRDAETLQKQKETIK 3158

Query: 292  ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR--EELITNWEQIRTL 349
            A L+K E L     A  D     C      +++ P     + +KR  E L     ++   
Sbjct: 3159 AFLKKLEAL----MASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDR 3211

Query: 350  AAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEH-- 406
            A  R  ++  +  RL+ F +  ++ +  + + +      E +    G E      Q +  
Sbjct: 3212 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE----HEESQGPVGMETETINQQLNMF 3267

Query: 407  ----KGEIDAHEDSFKSADESGQALLAAGHYAS---------DEVREKLTVLSEERAALL 453
                K EI+  +   +  +  GQ L+ +   ++         D+V  +   L+++ A   
Sbjct: 3268 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA--- 3324

Query: 454  ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS-LDSVEALLKKHEDF 512
               +   Q  E  +    F    E + +WM   E  + N+    +    V+A +++ +  
Sbjct: 3325 ---QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL 3381

Query: 513  EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-SRRNALHERAMRRRAQLAD 571
            ++ L  ++  +  +     K+      A +    ++ +LL SR  AL  +A  R  QL  
Sbjct: 3382 QRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3441

Query: 572  -SFHLQQFFRDSDELKSWVN--EKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
             S   QQF    + L  W+   EK     +      S L+ ++ +H+A E ++  +   +
Sbjct: 3442 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3501

Query: 629  DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV- 687
                  GQ L  ++     ++     +   +W   +E  E K     E  QQ   N  + 
Sbjct: 3502 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW--YIEIQE-KSHSRSELLQQALCNAKIF 3558

Query: 688  --EDIEL--WLYEVEGHLAS---DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
              +++EL  WL EV   L+     DY  +   +   Q +  +L+ D+   +  +D   + 
Sbjct: 3559 GEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELRVLQEDILLRKQNVDQALLN 3616

Query: 741  ARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEE- 797
              +   Q  G  +   I+ K EA+ ARY+ + +      + L  +L+L +      +E  
Sbjct: 3617 GLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3675

Query: 798  TWIR--EKEPIAASTN--RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
            TW+   E E ++  T   +G++    Q   K+   L+ E   ++  + ++ +  +A++E 
Sbjct: 3676 TWLDKVEVELLSYETQVLKGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLEL 3732

Query: 854  GHFAA-EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE-SWMREKEP 911
              + A E ++  + E N+++  +    +Q+ ++++ ++   Q F  A +AE SW+ E E 
Sbjct: 3733 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3792

Query: 912  ---IVGSTDYGKDEDSAEALLKK--------HEALMSDLSAYGSSIQAL--REQAQSCRQ 958
                +G     +D+ SA+  ++K        H+ ++ DL   G  I      E+ QS ++
Sbjct: 3793 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3852

Query: 959  QVAPTDDETGKELVLALYDY--QEKSPREVTMKKGDILTLLNSTNKDW--------WKVE 1008
            ++         + VL  YD   Q  S R + +++   L      N+ W        W  E
Sbjct: 3853 KL---------DKVLKNYDTICQINSERYLQLERAQSLV-----NQFWETYEELWPWLTE 3898

Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITK--------EAG 1060
                   +PA  ++     Q       L E   IA  +  ID   +           E  
Sbjct: 3899 TQSIISQLPAPALEYETLRQQQEEHRQLREL--IAEHKPHIDKMNKTGPQLLELSPGEGF 3956

Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVG 1120
            S+  +    + LY  + E  +KR   L+++  +   F +  ++ Q +       + E + 
Sbjct: 3957 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILE------SLERIV 4008

Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQ---QQEVYG 1177
              L Q   +  + +  ++ +  N++   D+ K+    E+     EE+ A      +++  
Sbjct: 4009 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4068

Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAE----ERSQLLGSAH 1233
               +D+ D      W++    +HT+     ++E   +   + +LAE    +   L+ +  
Sbjct: 4069 KAVQDKLDQMVFI-WEN----IHTL-----VEEREAKLLDVMELAEKFWCDHMSLIVTIK 4118

Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
            + Q F RD ++                 G D + V+  Q   E    ++  L ++++ + 
Sbjct: 4119 DTQDFIRDLEDP----------------GIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4162

Query: 1294 ETAERLIQSHPESAEDLQEKCT-ELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
                 LI +  E  + + +K   ELN AW SL K    R  KL ++     ++    + +
Sbjct: 4163 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4222

Query: 1352 MSWINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
              W++   G L S   +  D+   +  +E  ++ ++E   +    +      + LL    
Sbjct: 4223 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4282

Query: 1411 YASPE--IKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAF 1467
              S +  ++  L  L      LE+  + R+  L+  L  L  F    ++   W+   E  
Sbjct: 4283 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4342

Query: 1468 LNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
            L+ +   G    ++E  + KH      +   +  + A+    + LI +    +      +
Sbjct: 4343 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4402

Query: 1527 NEVLD-RWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEAWISE--------KLQTASD 1576
             EVL+ RW+ +  +  +++ +L G  +  + F  ++++++ W+++        K      
Sbjct: 4403 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4462

Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS-EDAVK 1635
            E+ K+  N+           H    A   A  +  + ++  G  ++ R  C  S E  + 
Sbjct: 4463 ETAKEQLNV-----------HMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNID 4509

Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALL-ASEDYGK 1693
              +  L ++W+ +  K  E+  KL+EA N    F+  ++DF  WL++ E  L  +     
Sbjct: 4510 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSL 4569

Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQ 1752
             L +V   + +H++   ++++H +++ +L+     L   S   D   +K+   ++  R++
Sbjct: 4570 ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWE 4629

Query: 1753 KIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTGVQNLRKK 1810
            K+      R   L+++  R  QF         W++E +  + SE +   D   ++    +
Sbjct: 4630 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4689

Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ--QRLAQFVEHWKELKQLAAARG 1868
            HK  +  L A          TG+ L +  ++  + ++    L++  + W  +   +  R 
Sbjct: 4690 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4749

Query: 1869 QRLEESLEYQ-QFVANVEEEEAWINEKMTLVASED--YGDTLAAIQGLLKKHEAFETDFT 1925
             +LEE+L +  QF   ++    W+      +A +   +GD +  +  L+  H+AF+ +  
Sbjct: 4750 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELG 4808

Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ 1985
                 V  +  + ++LI+ +      +  +M+ L+ +   +   +  ++ +L+  +A  Q
Sbjct: 4809 KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLE--AALRQ 4866

Query: 1986 FNWKADVVES---WIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
                  VV +   W+ E E +L+       D  +++TL+ + + F   L+  + E +   
Sbjct: 4867 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAE-LNKA 4925

Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMK-RWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
            T + D +LA  H  S        ++++ R+ ++LA +   +++L  A +     ++L   
Sbjct: 4926 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL-- 4983

Query: 2101 FAKKASAFNSWFENAEEDLTDP---VRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
                  A  +W + AE  LTD    V    +EE+KAL   H  F   ++  Q D +++ +
Sbjct: 4984 -----EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5038



 Score =  188 bits (477), Expect = 6e-47
 Identities = 502/2586 (19%), Positives = 1010/2586 (39%), Gaps = 326/2586 (12%)

Query: 14   DIQERRQ---QVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEEL-EKWIQEKLQIAS 68
            ++ E+RQ    + D   + K +S  + +   E    F + +  A++L E+W    +QI  
Sbjct: 1250 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI-- 1307

Query: 69   DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
            D   +D   L+G  +  + +          I +++ T   +       S+T+ T+L    
Sbjct: 1308 DNRLRD---LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---- 1360

Query: 129  RQWELLLEKMREKGIKLLQAQKLV-QYLRECEDVMDWINDKEAIVTSEELG-----QDLE 182
             Q ++L+ ++  K  K+ + QK   QY    +D         A+V S++       +   
Sbjct: 1361 NQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQS 1420

Query: 183  HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE-LIKTKQDEVNAAWQRLK 241
              +++ ++F + +T   A    + +  +FA   ++    EE+ L + K++ V  A +  K
Sbjct: 1421 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1480

Query: 242  GLA-LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH--- 297
             ++ + +  K    A    F++    +     +KEQL  +      L ++Q  L KH   
Sbjct: 1481 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEA------LQTIQLFLAKHGDK 1534

Query: 298  ------EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
                    LE+ +  L++    L +E+ +  Q    S T   VK EE I          A
Sbjct: 1535 MTDEERNELEKQVKTLQESYNLLFSESLKQLQE---SQTSGDVKVEEKIV---------A 1582

Query: 352  ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
            ER          Q +    + +   +T+ +  +   + A  +      L ++Q  + E+ 
Sbjct: 1583 ERQ---------QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1633

Query: 412  AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
                  K    S QAL        + ++E    LS+E  AL+E  +   +   +C  L L
Sbjct: 1634 ------KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKIKCEQLNL 1685

Query: 472  FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
                 EQ     SK+E           LD V     K E  + +   Q E+     E   
Sbjct: 1686 ---KAEQ-----SKKE-----------LDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1726

Query: 532  KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
              + N     E   T+   ++ + N  H +    ++ + +   +     ++D +   V  
Sbjct: 1727 DWLSNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGEEDEVNGNLLETD-VDGQVGT 1784

Query: 592  KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA 651
              +    +  K  +  +  + +HQA    + A QS    LEK GQ L   +   K+++  
Sbjct: 1785 TQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYL---SPEEKEKLQK 1838

Query: 652  RMNEVISLWKKLLEATELKGIKLREANQQQ--QFNRNVEDIELWLYEVEGHLASDDYGKD 709
             M E+   ++  L  +E K +KL  + Q++  +F+ +  + E WL + E  L + + G D
Sbjct: 1839 NMKELKVHYETALAESEKK-MKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1897

Query: 710  -LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF---------QDAGHFDAE----NI 755
             +  +    K+      DV +H+  +  ITI   +          +D G  D       +
Sbjct: 1898 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1957

Query: 756  KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED---------EETWIRE-KEP 805
            ++K +    R+ +L          L D +   Q + D            E T  +   EP
Sbjct: 1958 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2017

Query: 806  IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGHF--AAEDVK 862
            IA       D   +Q  L++ +ALQ +I+  +  ++ + +    +++  G    A  D++
Sbjct: 2018 IAV------DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2071

Query: 863  AKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA-NEAESWMREKEPIVGSTDYGKD 921
              L ++  ++E L    ++R + L+ +L       D  +E   WM   E  +        
Sbjct: 2072 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2131

Query: 922  EDSA-EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
              +A + ++ K+  L  D++   SSI A+ E+ +   +    TD  T   L   + D   
Sbjct: 2132 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET---TDPSTASSLQAKMKDLSA 2188

Query: 981  KSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG 1040
            +   E + K  + L  +        KVE+ +          +KL        + L E   
Sbjct: 2189 RFS-EASHKHKETLAKMEELKT---KVELFENLS-------EKLQTFLETKTQALTE--- 2234

Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE------LGEKRKGMLEKSCKKF 1094
             + +  + +   ++  +E+ S  L  K+  E+ HSLL+      L   +  +LEK+    
Sbjct: 2235 -VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNN-- 2291

Query: 1095 MLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK------ 1148
             L ++  E++  I EK+ A+TS +    L+  +VL K    + K+       ++      
Sbjct: 2292 -LSKKFKEMEDTIKEKKEAVTSCQ--EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2348

Query: 1149 DINKVAEDL----ESEGLMAEEVQAVQQQEVY--GMMPRDETDSKTASPWKSARLMVHTV 1202
            D+ K  ED     E   L   E+Q V    +    ++    T +K  +  KS   +++  
Sbjct: 2349 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2408

Query: 1203 ATFNSIKEL--NERWRSLQQ---------------LAEERSQLLGSAHEVQRFHRDADET 1245
             T  + +E   N+   S+++               L ++ ++L     ++Q+   ++   
Sbjct: 2409 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2468

Query: 1246 KEWIEEKNQALNTDNYGH---DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
             +W+++ N+            D  +V+    +++ FE +L    +KV  L +    L++ 
Sbjct: 2469 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2528

Query: 1303 HPESAEDLQEK--CTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIR 1359
            +P++ E  + K   TE++  W  L +    R+ KL +S ++L +F +    L  W+    
Sbjct: 2529 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2588

Query: 1360 GLVSS-DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
             +VS    L+ D        ++ Q    E   R   ++     GQ +L+      P ++ 
Sbjct: 2589 LMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG-EDPSLR- 2646

Query: 1419 KLDILDQERADLEKAWVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK--GD 1475
               I+ ++ A + + W      L D+C  +        Q ++ + +    L+  D     
Sbjct: 2647 --GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2704

Query: 1476 SL------DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAA--GHYAKGDISSRRN 1527
            SL      D++   ++  +   + I  ++++I   QA  + L A     Y K ++S +  
Sbjct: 2705 SLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLE 2764

Query: 1528 EVLDRWRRLKAQ----MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
             +L  ++ ++ +    +   +S    S   QQ SRD    +AW+  K +   +++   P 
Sbjct: 2765 GILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD---FQAWLDTKKE---EQNKSHPI 2818

Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA-VKARLAALA 1642
            + +L  L S  + H+ F   L A +      I  G +L+ +    GSE A ++ +L  + 
Sbjct: 2819 SAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEKAALQLQLNTIK 2876

Query: 1643 DQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
              W    ++  E+  KLKE+  K   +   ++    W+ + +  L    +  D A   N 
Sbjct: 2877 TNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENS 2936

Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
            + K + L+ ++  H   ++ LN+ A+SL++    D   V D+  ++  +   +     S+
Sbjct: 2937 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2996

Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG-RDLTGVQNLRKKHKRLEAELAA 1820
            +  L    +  + F+++  E     +++L    E     D  G Q    K+  +      
Sbjct: 2997 KFCLENMTQKFKEFQEVSKES----KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK 3052

Query: 1821 HEPAIQGVLDTGKKLSDDNTI------GKEEIQQRLAQFVEHWKELKQLAAARGQRLEES 1874
               A++  +D  K+L+ D  +      G  ++  ++    +    L Q    +   LE  
Sbjct: 3053 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3112

Query: 1875 LE----YQQFVANVEEEEAWINEKMTLVA-----SEDYGDTLAAIQGLLKKHEAFETDFT 1925
            L+    +Q  +  +  + A  ++++  +A     +E        I+  LKK EA      
Sbjct: 3113 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS-- 3170

Query: 1926 VHKDRVNDVCT-------NGQDLI----------KKNNHHEENISSKMKGLNGKVSDLEK 1968
               D  N  C           DL+          K+ N   +   ++ + + G +  LE+
Sbjct: 3171 --NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE 3228

Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
              +    KL E S  LQ   KA+  E   G     ++T+   + L+  + +  K+E    
Sbjct: 3229 FYS----KLKEFSILLQ---KAEEHEESQGPV--GMETETINQQLNMFK-VFQKEEI--E 3276

Query: 2029 GLQAFQQEGIANITALKDQLL--AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE 2086
             LQ  QQ+    +  L   L+  AAK   ++ +E     +  RW  L    A R  +L E
Sbjct: 3277 PLQGKQQD----VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3332

Query: 2087 AQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP--------VRCNSLEEIKALREAH 2138
            A  H  + +D          +  SW  + EE + +         V    ++E K L+   
Sbjct: 3333 ALLHCGRFQDAL-------ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLL 3385

Query: 2139 DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELEL 2198
            D  +S++   + +  ++A         ++         +  L+  W  L    + R  +L
Sbjct: 3386 DDRKSTVEVIKREGEKIATTAEPADKVKILKQ------LSLLDSRWEALLNKAETRNRQL 3439

Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
                   E    + Q+F +     ++W+      L++   +  ++  LE Q+   K    
Sbjct: 3440 -------EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3492

Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQW-DQLDQLGMRMQHNLEQQI 2317
            +I      L +   +G +++     ++K    S +  +Q W  ++ +        L+Q +
Sbjct: 3493 DIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQAL 3552

Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEF--------KSCLRSLGYDLPMVEE 2369
                  G  E  L    M + +   DK  +L+ Q++        +S LR L  D+ + ++
Sbjct: 3553 CNAKIFGEDEVEL----MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3608

Query: 2370 GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAF-RALSSEGKPY 2428
                     +        D  + +Q+ +  + +R  +  K S ++     +AL    + +
Sbjct: 3609 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3668

Query: 2429 VTKEEL 2434
             T EEL
Sbjct: 3669 STHEEL 3674



 Score =  167 bits (423), Expect = 1e-40
 Identities = 206/996 (20%), Positives = 441/996 (44%), Gaps = 77/996 (7%)

Query: 1    MDPSGVKVLETAE----DIQERRQQVLDRYHRFKELSTLRRQKLED--SYRFQFFQRDAE 54
            M+ +G ++LE +      IQE+       Y + KE    R   L++  S   QF  +  +
Sbjct: 3940 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3999

Query: 55   ELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD----------E 104
             LE    E++     E  + P ++  +++K    + ++  N    V ++          +
Sbjct: 4000 ILESL--ERIV----ERLRQPPSISAEVEK---IKEQISENKNVSVDMEKLQPLYETLKQ 4050

Query: 105  TGNLMISEG-----HFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ------ 153
             G  MI+         +++ ++ +L ++   WE +   + E+  KLL   +L +      
Sbjct: 4051 RGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4110

Query: 154  --YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
               +   +D  D+I D E      + G D   V+  Q+  E  + ++   +E ++ V   
Sbjct: 4111 MSLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4164

Query: 212  AAKLIQE-QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETIS 269
             ++LI     P++ ++K   DE+N+AW  L      R  KL  A +   ++   +     
Sbjct: 4165 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4224

Query: 270  WIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLS 328
            W+      +AS    G DL +V+  + + +  + +    + +++ L  +A+ L +     
Sbjct: 4225 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4284

Query: 329  ATQ--IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALIN 385
            + +  +Q    EL   W+ +      R  +L  +   L +F     +L +W+T  + L++
Sbjct: 4285 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4344

Query: 386  ADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASDEVREKL 442
              + +  D    E  L +H   + ++ AH+ + ++ +++G  L+  +AG  AS+ ++ KL
Sbjct: 4345 EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN-LQNKL 4403

Query: 443  TVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLL-NEDLGDSLD 500
             VL++    +LE  E R+QQ +  +   + F+ + E +  W++  E  LL ++ LG   +
Sbjct: 4404 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4463

Query: 501  SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAME-DVATRRDALLSRRNALH 559
            + +  L  H +   +  A+EE   +L +   +++     + E ++    + L  +  ++ 
Sbjct: 4464 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4523

Query: 560  ERAMRRRAQLADSFHLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQG----KVQKH 614
             +   R+ +L ++ +L   F +S  +  +W+ +  +T        PS +      ++ +H
Sbjct: 4524 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN--VASRPSLILDTVLFQIDEH 4581

Query: 615  QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISL---WKKLLEATELKG 671
            + F  E+++++ +I  L+K G  L   +   K +V    N +IS+   W+K+++    +G
Sbjct: 4582 KVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERG 4639

Query: 672  IKLREANQQ-QQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNLQKKHALLEADVAA 729
              L +A ++ +QF+     +  WL E E  L S+ +   D   ++    +H   +  + A
Sbjct: 4640 RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA 4699

Query: 730  HQDRIDGITIQARQFQDAGHFDAENIKKKQ--EALVARYEALKEPMVARKQKLADSLRLQ 787
                 D      R  ++      +N+K       L  +++ +    V R+ KL ++L   
Sbjct: 4700 KHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4759

Query: 788  QLFRD-VEDEETWIREKEP-IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
              F D ++    W+   EP +A       D+  V NL+  H+A Q E+      ++A+ +
Sbjct: 4760 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4819

Query: 846  KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAES 904
                ++E     +  VK ++ EL+ +WE + A +  ++  LE +L QA+++ +  +    
Sbjct: 4820 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4879

Query: 905  WMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDL 939
            W+ E E  +        DED+   L+ +H+  M  L
Sbjct: 4880 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL 4915



 Score =  160 bits (405), Expect = 1e-38
 Identities = 484/2522 (19%), Positives = 976/2522 (38%), Gaps = 424/2522 (16%)

Query: 9    LETAEDIQERRQQVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA 67
            ++  E  Q + Q+  ++    K L+T L +QK+  S   +  Q   +E +K+ ++     
Sbjct: 1335 IQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVS-EIEMKQSKMDECQKYAEQYSATV 1391

Query: 68   SDENYKDPTN--LQGKLQKHQAFEAEVQANSGAIV--------KLDETGNLMISEGHFAS 117
             D   +  T   +    QK       +Q+++  I+        +      LM     FA 
Sbjct: 1392 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1451

Query: 118  ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLV----QYLRECEDV------MDWIND 167
            ++++     L  + + L E+ +E   K  + QK V    + L++ E           I+ 
Sbjct: 1452 DSLK----RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1507

Query: 168  KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE---------ERVNEVNQFAAKLIQE 218
            +E     E+L + L+ +++   K  +  TD   +E         E  N +   + K +QE
Sbjct: 1508 EEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1567

Query: 219  QHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
                     EE+++  +Q E     Q +  L  Q + +L G  E         E   +  
Sbjct: 1568 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1627

Query: 273  EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
            ++E+L   D  G   A  + +      L+ +   L  + KAL  +  +L ++  +   Q+
Sbjct: 1628 KQEELQ-KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ--KLNEAK-IKCEQL 1683

Query: 333  QVKREELITNWEQIRTLAA-ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELAS 391
             +K E+     +++ T A  E   ++    +L+       +L  W++      N D+  S
Sbjct: 1684 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DS 1736

Query: 392  DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
            + AG +        HK  I+ +   F+  D  G++ +       DEV   L + ++    
Sbjct: 1737 ERAGTK--------HKQVIEQNGTHFQEGD--GKSAIGE----EDEVNGNL-LETDVDGQ 1781

Query: 452  LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
            +    E   QQY++            Q +  +S+ +A ++      +  S + LL+K   
Sbjct: 1782 VGTTQENLNQQYQKVK---------AQHEKIISQHQAVII------ATQSAQVLLEKQGQ 1826

Query: 512  FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
            +   LS +E++         KL +N    M+++    +  L+      E+ M+    L +
Sbjct: 1827 Y---LSPEEKE---------KLQKN----MKELKVHYETALAES----EKKMKLTHSLQE 1866

Query: 572  SFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSN-LQGKVQKHQAFEAELSANQSRID 629
               L++F  D  E + W+ +  +   + EA  D  N L  K+++ ++F  ++ +++  + 
Sbjct: 1867 E--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1924

Query: 630  ALEKAGQKLIDVNHYAKD-------------EVAARMNEVISLWKKLLEATELKGIKLRE 676
             +  +G ++++                    EV  +++     ++ L     + G  L++
Sbjct: 1925 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1984

Query: 677  ANQQQQFNRNVE-----DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
               + Q   +        ++        HL S+    D  N+Q   ++   L+  +++ Q
Sbjct: 1985 LVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQ 2043

Query: 732  DRIDGITIQARQFQDA--GHFDAEN-IKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
              ++ +   A    DA      A+N I+K  + +V RYE L + +  R +KL  +L    
Sbjct: 2044 VAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2103

Query: 789  LFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
              +D  DE        E+ ++E+  +  ++        +Q+++ K+  L+ +IAG +  I
Sbjct: 2104 SVQDGLDEMLDWMGNVESSLKEQGQVPLNST------ALQDIISKNIMLEQDIAGRQSSI 2157

Query: 841  KAVTQKGNAMVEEGH-FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA 899
             A+ +K    +E      A  ++AK+ +L+ ++     K  +    +E+     + F + 
Sbjct: 2158 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 2217

Query: 900  NEA-ESWMREKEPIVGSTDY-GKD---------EDSAEALL-KKH----EALMSDLSAYG 943
            +E  ++++  K   +   D  GKD         E ++E L  KKH     +L+ ++S++G
Sbjct: 2218 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 2277

Query: 944  -----------------------SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
                                    +I+  +E   SC++Q+     +  + LV +L  + +
Sbjct: 2278 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL-----DAFQVLVKSLKSWIK 2332

Query: 981  KSPREVTMKKG-----DILTLLNSTNK--DWWKVEVNDRQ-----GFVPAAYVKKLD-PA 1027
            ++ ++V + +      D+   L  T K  + W ++  + Q     G      +  +  PA
Sbjct: 2333 ETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPA 2392

Query: 1028 QSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGML 1087
            ++ +    ++  G++   +    N        G  S++ K + ++ H   +LG   K  +
Sbjct: 2393 KAIAA---VKSGGAVLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI 2448

Query: 1088 EKSCKKFMLFREANE----LQQWINEKEAALTSEE---VGADLEQVEVLQKKFDDFQKDL 1140
             +   K    ++A E    + QW+ +     T  +      D E V+   ++   F+ +L
Sbjct: 2449 AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2508

Query: 1141 KANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
            K N ++++++ +K+ E LE                       +  D+  A  WK      
Sbjct: 2509 KQNVNKVQELKDKLTELLE-----------------------ENPDTPEAPRWKQM---- 2541

Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIEEKN----- 1253
                    + E++ +W+ L QL  +R Q L  S++ + +F     + K+W+ EK      
Sbjct: 2542 --------LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2593

Query: 1254 --------QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPE 1305
                      LNT      +   +   RK + +E+  AA    ++  GE         P 
Sbjct: 2594 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQ-YEQLTAAGQGILSRPGED--------PS 2644

Query: 1306 SAEDLQEKCTELNQAWSSL----GKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
                ++E+   + Q W SL      R D     +  S   Q  L    D +S ++    L
Sbjct: 2645 LRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KL 2702

Query: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQL--LAHGHYASPEIKQK 1419
             SS  ++         LE  Q+ + EI       +  +   + L  L    Y   E+ ++
Sbjct: 2703 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2762

Query: 1420 LDILDQERADLE-KAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK-GDSL 1477
            L+ + +   D+E KA    + +   C     F +     + W+  ++   N        L
Sbjct: 2763 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2822

Query: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA-KGDISSRRNEVLDRWRRL 1536
            D +E+LIK H+DF K +  Q        A  + L+     + K  +  + N +   W   
Sbjct: 2823 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2882

Query: 1537 KAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS------EKLQTASDESYKDPTNIQLSK 1589
              Q+ E+ +KL ES +   ++   V+ +  WI       E+++   D +  + +  +L  
Sbjct: 2883 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2942

Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLI--ERGACAGSEDAVKARLAALADQWQF 1647
            L  +  +H      L+  A+ +  V ++   ++  E  +     D V  +L +     + 
Sbjct: 2943 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3002

Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQ 1706
            + QK  E  +  KE+ +Q        D       +   L S+ Y  K L  +    K  Q
Sbjct: 3003 MTQKFKEFQEVSKESKRQLQCAKEQLD-------IHDSLGSQAYSNKYLTMLQTQQKSLQ 3055

Query: 1707 LLEADISAHEDRLKDLNSQA-DSLMTSSA-FDTSQVKDKRDTINGRFQKIKSMAASRRAK 1764
             L+  +   +   +DL  +A DS  TS        +  +  T++   Q++    +    K
Sbjct: 3056 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS---QQVDEKCSFLETK 3112

Query: 1765 L-------NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ----NLRKKHKR 1813
            L       N    +   F + DDE         L      GRD   +Q     ++   K+
Sbjct: 3113 LQGIGHFQNTIREMFSQFAEFDDE---------LDSMAPVGRDAETLQKQKETIKAFLKK 3163

Query: 1814 LEAELAAHEPAIQGVLDTGKKL--SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1871
            LEA +A+++ A +    T K +  +++ +     I++ L    +   +L   A AR +++
Sbjct: 3164 LEALMASNDNANK----TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3219

Query: 1872 EESLE-YQQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQGLLKKHEAFE-TDFTVHK 1928
            E +++  ++F + ++E    + +      S+   G     I   L   + F+  +    +
Sbjct: 3220 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3279

Query: 1929 DRVNDVCTNGQDLIKK--NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
             +  DV   GQ LI+    +   + +   +  +N +   L K  AQR A+L E  A L  
Sbjct: 3280 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE--ALLHC 3337

Query: 1987 NWKADVVE---SWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT 2042
                D +E   SW+ + E  +        +   V+  + +Q+     LQ    +  + + 
Sbjct: 3338 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL----LQRLLDDRKSTVE 3393

Query: 2043 ALK---DQLLAAKHVQSKAIEARHASLM-KRWSQLLANSAARKKKL----LEAQSHFRKV 2094
             +K   +++        K    +  SL+  RW  LL  +  R ++L    + AQ     +
Sbjct: 3394 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3453

Query: 2095 EDL--FLTFAKKA---------------------SAFNSWFENAEEDLTDPVRCNSLEEI 2131
            E L  +LT  +K                       A      N  + L   V      ++
Sbjct: 3454 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3513

Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
             + RE  D  +S L     DF+Q+  ++ Q KS             E L++   N  KI 
Sbjct: 3514 LSSREDKDMVQSKL-----DFSQVWYIEIQEKSHS---------RSELLQQALCN-AKIF 3558

Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT------ 2245
             E E+EL       E +DKL +   Q  +    W Q++   +L    ++ +         
Sbjct: 3559 GEDEVELM--NWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3616

Query: 2246 ---------------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEH 2290
                           ++ +LEA K ++++I  + +      D+   +E+AL L  +   H
Sbjct: 3617 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST------DVAKTLEQALQLARRL--H 3668

Query: 2291 ST 2292
            ST
Sbjct: 3669 ST 3670



 Score =  112 bits (281), Expect = 3e-24
 Identities = 330/1819 (18%), Positives = 696/1819 (38%), Gaps = 265/1819 (14%)

Query: 669  LKGIKLREANQQQQFNRN-VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
            LK   L +   +++ N   V+D+  W+ E++  L   ++G DL +V++  + H  +   +
Sbjct: 618  LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 677

Query: 728  AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
               +  +    I   Q             +K   L ++Y  L      +++ L     L 
Sbjct: 678  EEFESSLKEAKISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQERHLDT---LH 731

Query: 788  QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
                   +E  W+ EKE    + +  +    +      H  L  E+   E  IK+V +  
Sbjct: 732  NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIA 791

Query: 848  NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
              ++ E H A   ++A    +  +W  +        Q ++++    ++F DA EA  ++R
Sbjct: 792  EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 851

Query: 908  EKEPIVG---STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
              +  +    S D        E L+++      +L  Y S+I  L  +A++  Q      
Sbjct: 852  NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 911

Query: 965  DETGKEL--VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV 1021
            D   K    + A+ DY++    E+T+ K D   L N++++  WKV      +  VP+   
Sbjct: 912  DCPLKTSIPIKAICDYRQ---IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCF 968

Query: 1022 KKLDPAQSA-SRENLLEE--QGSIALRQEQIDNQTRIT------------KEAGSVSLRM 1066
                P + A    N +E+  Q  + L  E   N   +             + +   S++ 
Sbjct: 969  TVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKT 1028

Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKK--------FMLFREANELQQWINEKEAALTSEE 1118
                E    L  L  + +  LE S +           L +E N  +Q+  E   +   EE
Sbjct: 1029 MLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREE 1088

Query: 1119 ------------------------------VGADLEQVEVLQKKFD-DFQKDLKANESRL 1147
                                          +   LE+ ++ +  F    Q+ LK    RL
Sbjct: 1089 QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL 1148

Query: 1148 KD----INKVAEDLESEGLMAEEVQAVQQQ---------EVYGM----MPRDETDSKTAS 1190
            KD    I    E+  S+   +  V  ++ +         +VY M    + + +T +    
Sbjct: 1149 KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 1208

Query: 1191 PWKSARLMVH-----------TVATFNSIKEL---NERWRS--------LQQLAEERSQL 1228
              ++A  +V             +A  N+I+ L    ++WRS           L +E  + 
Sbjct: 1209 NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 1268

Query: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
               + E+ + +++ D   +W +EK   L  + + +    +    R  EG  + L    D 
Sbjct: 1269 KAISDEMFKTYKERDLDFDWHKEKADQL-VERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1327

Query: 1289 VNSLG------ETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD- 1340
             + L       ET +R IQ + PE+++ L    T+LNQ    L    + +++K+ +    
Sbjct: 1328 YHPLDDWIQQVETTQRKIQENQPENSKTL---ATQLNQQ-KMLVSEIEMKQSKMDECQKY 1383

Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELA-----KDVTGAEALLERHQEHRTEIDARAGTF 1395
             +++ +  +D        R +V S + +     +  + A+ +++   + RT   A     
Sbjct: 1384 AEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1443

Query: 1396 QAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF----- 1450
              + +F          A   +K+    L++E   LE+   +++  +++  ELQ +     
Sbjct: 1444 TQYIKF----------AGDSLKR----LEEEEKSLEE---EKKEHVEKAKELQKWVSNIS 1486

Query: 1451 --HRDCEQA------ENWMAAREAFLNTEDKGDSLDSVEALIKKHED--FDKAINVQEEK 1500
               +D E+A      +  +++ E     E   ++L +++  + KH D   D+  N  E++
Sbjct: 1487 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1546

Query: 1501 IAALQAFADQLIAAG------HYAKGDISSRRNEVLDRWRRLKAQ-------MIEKRSKL 1547
            +  LQ   + L +            GD+      V +R +  K +       + +  ++L
Sbjct: 1547 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1606

Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASD---------ESYKDPTNI---------QLSK 1589
               Q          E++ + S++ +   D         E  K+  N          Q  K
Sbjct: 1607 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1666

Query: 1590 LLSKHQKHQAFE--AELHANADRIRGVIDMG-----NSLIERGACAGSEDAVKARLAALA 1642
             L + + ++A     +L+  A++ +  +D           E+ A     +  K ++  L 
Sbjct: 1667 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1726

Query: 1643 DQWQFLVQKSAEKS-QKLKEANKQQNFNTGIKDFDFWLSEVEA----LLASEDYGKDLAS 1697
            D W   V K +E++  K K+  +Q   +    D    + E +     LL ++  G+   +
Sbjct: 1727 D-WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1785

Query: 1698 VNNLLKKHQLLEAD----ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
              NL +++Q ++A     IS H+  +    S    L     + + + K+K    N +  K
Sbjct: 1786 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK-NMKELK 1844

Query: 1754 IKSMAA----SRRAKLNES--HRLHQFFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQN 1806
            +    A     ++ KL  S    L +F  D  + E W+++ +  + + + G  D+ G+  
Sbjct: 1845 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 1904

Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSD-------------DNTIGKEEIQQRLAQF 1853
              K+ K    ++ +H+  ++ +  +G ++ +             D +    E+Q++L   
Sbjct: 1905 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 1964

Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQF-------VANVEEEEAWINEKMTLVASEDYGD 1905
             + ++ L       G  L++ ++ YQ +       +A ++  EA  ++ +    SE    
Sbjct: 1965 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL----SEPIAV 2020

Query: 1906 TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH---HEENISSKMKGLNGK 1962
                +Q  L++ +A +   +  +  V  +    + L+         + +I   +  + G+
Sbjct: 2021 DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR 2080

Query: 1963 VSDLEKAAAQRKAKLDEN-SAFLQFNWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLL 2020
              DL K+  +R  KL    +  L      D +  W+G  E+SLK       + +++Q ++
Sbjct: 2081 YEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDII 2140

Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
            +K    +  +   Q    ++I A+ +++         +  +   + MK  S   + ++ +
Sbjct: 2141 SKNIMLEQDIAGRQ----SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2196

Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
             K+ L      +   +LF   ++K   F      A  ++  P +     ++  L +    
Sbjct: 2197 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGK-----DVTELSQYMQE 2251

Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQK 2200
              S     +     L  L ++I S  + S+         LE+T  NL K  KE E  +++
Sbjct: 2252 STSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL-----VLEKT-NNLSKKFKEMEDTIKE 2305

Query: 2201 EQRRQEENDKLRQEFAQHANAFHQWIQET--RTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
            ++       +    F     +   WI+ET  +  ++  S   E+ G     LE TK+  +
Sbjct: 2306 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLEDTKKLQE 2362

Query: 2259 EIRAMRSQLKKIEDLGAAM 2277
            +      +++K+ + G ++
Sbjct: 2363 KWSLKTPEIQKVNNSGISL 2381



 Score =  102 bits (255), Expect = 4e-21
 Identities = 450/2452 (18%), Positives = 904/2452 (36%), Gaps = 352/2452 (14%)

Query: 30   KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ--IASDENYKDPTNLQGKLQKHQA 87
            K L+T R Q+        F  R   EL  W+ EK +  +A D + ++ TN+  K   H  
Sbjct: 715  KLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEEEVAYDWSERN-TNIARKKDYHAE 772

Query: 88   FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQ 147
               E+      I  + E    ++ E H A  TI      +  QW  +L+           
Sbjct: 773  LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ----------L 822

Query: 148  AQKLVQYLRECEDVMDWIND-KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
             Q + Q+++E     ++ ND KEA      L       + +Q+K+           +R +
Sbjct: 823  CQCVEQHIKENTAYFEFFNDAKEATDYLRNL------KDAIQRKYS---------CDRSS 867

Query: 207  EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK---LFGAAEVQRF--N 261
             +++    + +    +EEL++ K    N   +    + L+ +     L  +  ++     
Sbjct: 868  SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 927

Query: 262  RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL 321
            R ++ TI   K+ E ++A++        +                 E  V ++C      
Sbjct: 928  RQIEITI--YKDDECVLANNSHRAKWKVISP------------TGNEAMVPSVCFTVPPP 973

Query: 322  QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF-RDLTSWVTEM 380
             +     A +I+ + + ++T W        E H  +         + +  R   S V  +
Sbjct: 974  NKEAVDLANRIEQQYQNVLTLWH-------ESHINMKSVVSWHYLINEIDRIRASNVASI 1026

Query: 381  KALINADE---LASDVAGAEALLDRHQEHK----GEIDAHEDSFKSADESGQALLAAGHY 433
            K ++  +    L++  +  E  L+  QE +     +I   E       +  Q LL +   
Sbjct: 1027 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1086

Query: 434  ASDEVREKLTVLSEERAALLELWELRRQQYEQCM------DL-QLFYRDTEQVDNWMSKQ 486
               E       +SE R   L L     +   Q        DL +  +R TEQ      K+
Sbjct: 1087 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE---KLKK 1143

Query: 487  EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
            E   L +DLG        +  K E+F  S +A    +  L      ++QN +      +T
Sbjct: 1144 ELERLKDDLG-------TITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 1195

Query: 547  RRDAL----LSRRNALHERAM---------RRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
              D L    L  +N     A+            A +AD  +++       + +S V+EK 
Sbjct: 1196 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1255

Query: 594  K---TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKL-IDVNHYAKD-- 647
            +      DE  K  +      + ++  + +   ++ + D L +  Q + + +++  +D  
Sbjct: 1256 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1315

Query: 648  ------EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHL 701
                  +        +  W + +E T+ K I+  +    +     +   ++ + E+E   
Sbjct: 1316 GIGKSLKYYRDTYHPLDDWIQQVETTQRK-IQENQPENSKTLATQLNQQKMLVSEIEMKQ 1374

Query: 702  AS-DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQE 760
            +  D+  K         K + L      A  D      ++ R+ Q +    A+ I ++  
Sbjct: 1375 SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS----ADLIIQEFM 1430

Query: 761  ALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGV 819
             L  RY AL   M    +   DSL RL++  + +E+E     +KE +  +    K +  +
Sbjct: 1431 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-----KKEHVEKAKELQKWVSNI 1485

Query: 820  QNLLKKHQALQAEIAGHEP--RIKAVTQKGNAMVEEGHFAAEDVKAKL------------ 865
               LK      AE AG  P  + K  +++ +   E+   A + ++  L            
Sbjct: 1486 SKTLK-----DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1540

Query: 866  HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE-----KEPIVGSTDYGK 920
            +EL ++ + L+   +    +    LQ  Q   D    E  + E     KE + G  D   
Sbjct: 1541 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLT 1600

Query: 921  DEDSAEALLKKHEALM-----SDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLAL 975
              ++   L+   EA M      +L  Y S  + L++  Q   Q +A    E  K     L
Sbjct: 1601 QTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA----EVVKNTENFL 1654

Query: 976  YDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035
             +  EK  +E    K  I   LN       ++ +   Q        K+LD   + +   +
Sbjct: 1655 KENGEKLSQE---DKALIEQKLNEAKIKCEQLNLKAEQS------KKELDKVVTTA---I 1702

Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
             EE   +A  ++  +++T+I      +S   K  E         G K K ++E++   F 
Sbjct: 1703 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE-------RAGTKHKQVIEQNGTHF- 1754

Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK-DINKVA 1154
                     Q  + K A    +EV  +L + +V   +    Q++L     ++K    K+ 
Sbjct: 1755 ---------QEGDGKSAIGEEDEVNGNLLETDV-DGQVGTTQENLNQQYQKVKAQHEKII 1804

Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
               ++  +  +  Q + +++   + P ++   +                   ++KEL   
Sbjct: 1805 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ------------------KNMKELKVH 1846

Query: 1215 WRSLQQLAEERSQLLGS-AHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQ 1272
            + +    +E++ +L  S   E+++F  D  E + W+++  Q L N +    D+  +    
Sbjct: 1847 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1906

Query: 1273 RKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE-------------DLQEKCTELNQ 1319
            ++ + F  D+ +    +  +  +  R++++    ++             ++Q K      
Sbjct: 1907 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1966

Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVS---SDELAKDVTGAE 1375
             + SL  + +     L D  D  +   D    L++ +       S   S+ +A D    +
Sbjct: 1967 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2026

Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLL-AHGHY--ASPEIKQKLDILDQERADLEK 1432
              LE  +  + +I ++    +  ++  + LL A G    A  +I++ LD +     DL K
Sbjct: 2027 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2086

Query: 1433 AWVQRRMMLDQCLELQLFHRD-CEQAENWMAAREAFLNTE-----DKGDSLDSVEALIKK 1486
            +  +R   L   L   L  +D  ++  +WM   E+ L  +     +     D +   I  
Sbjct: 2087 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2146

Query: 1487 HEDF---DKAINVQEEKIAALQAFADQLIAAGHYAK-GDISSRRNEVLDRWRRLKAQMIE 1542
             +D      +IN   EK+       D   A+   AK  D+S+R +E   + +   A+M E
Sbjct: 2147 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2206

Query: 1543 KRSKLGESQTLQQFSRDVDEIEAWISEKLQ--TASDESYKDPTNIQ--LSKLLSKHQKHQ 1598
             ++K      ++ F    ++++ ++  K Q  T  D   KD T +   + +  S+  +H+
Sbjct: 2207 LKTK------VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2260

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
                 LH+               I        +  V  +   L+ +++ +     EK + 
Sbjct: 2261 KHLEVLHSLLKE-----------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 2309

Query: 1659 LKEANKQQN-FNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLLKKHQLLEA 1710
            +    +Q + F   +K    W+ E       V+    +ED GK L     L +K  L   
Sbjct: 2310 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2369

Query: 1711 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTING--------RFQKIKSMAASRR 1762
            +I    +    L     S +T+ A   + VK     +NG         F   K + + ++
Sbjct: 2370 EIQKVNNSGISL-CNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2428

Query: 1763 AKLNESHRLHQFFRDMDDEESWIKEK--KLLVGSEDYGRDLTGVQNLRK----------- 1809
               + SH        + D+ + +  K  KL    E+    +  +Q + K           
Sbjct: 2429 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2488

Query: 1810 -----------KHKRLEAELAAHEPAIQGVLDTGKKLSDDN--TIGKEEIQQRLAQFVEH 1856
                       ++K  EAEL  +   +Q + D   +L ++N  T      +Q L +    
Sbjct: 2489 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2548

Query: 1857 WKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL- 1914
            W+EL QL   R Q+LEES     QF     + + W+ EK  +V+       L+    +L 
Sbjct: 2549 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS---VLGPLSIDPNMLN 2605

Query: 1915 ---KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE----------NISSKMKGLNG 1961
               ++ +    +F   K +   +   GQ ++ +                 ++ K   L G
Sbjct: 2606 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2665

Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
            ++SD      Q   K  +  + L               +  S K  D    LSS   + T
Sbjct: 2666 QLSDRCDWIDQAIVKSTQYQSLL---------------RSLSDKLSDLDNKLSSSLAVST 2710

Query: 2022 KQETFDAGLQAFQQEGIANITALKDQLLAAKHV---QSKAIEARH--ASLMKRWSQLLAN 2076
              +  +  L+  Q+     I   K Q+  A+ +    S  ++  +  A L ++   +L +
Sbjct: 2711 HPDAMNQQLETAQKMK-QEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2769

Query: 2077 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE--NAEEDLTDPVRCNSLEEIKAL 2134
                ++K      H +        F + +  F +W +    E++ + P+    L+ +++L
Sbjct: 2770 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA-KLDVLESL 2828

Query: 2135 REAHDAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
             + H  F  +L++    + + +AE +  +   + +        +  ++  W    K +KE
Sbjct: 2829 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2888

Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLD-GSCMVEESGTLESQLEA 2252
            RE +L       +E+ +   ++ +       WI + +  L +   C+    G  E+ +  
Sbjct: 2889 RENKL-------KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG--ENSIAK 2939

Query: 2253 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQ 2304
             K   +E+      ++ + +   ++     +D +        L Q+ D + +
Sbjct: 2940 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 2991



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 87/439 (19%), Positives = 179/439 (40%), Gaps = 52/439 (11%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIASDENY 72
            + +   ++ D++      S  R+ KLE++  F     DA + L  W+   + Q+A D+  
Sbjct: 4727 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4786

Query: 73   KDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
                +L    +  H+AF+ E+   + ++  L  +   +I      S  ++ ++ EL  +W
Sbjct: 4787 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4846

Query: 132  ELLLEKMREKGIKLLQAQKLVQYLRECED-------VMDWINDKEAIVTSEE-LGQDLEH 183
            E +        + + +  +L   LR+ E+       +++W+ + E  +     L  D + 
Sbjct: 4847 ETVC------ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4900

Query: 184  VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEE-ELIKTKQDEVNAAWQRLKG 242
            +  L  + +EF   +      +N+       ++   HP+    IK     + A ++ +  
Sbjct: 4901 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4960

Query: 243  LALQRQGKLFGAAEVQRFNRDVDETI-SWIKEKEQLMASDD---FGRDLASVQALLRKHE 298
             A Q Q +L  A       +++ E + +W++  E  +   D     +++  V+AL+ +H+
Sbjct: 4961 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5020

Query: 299  GLERDLAALE---DKV----KALCAEADRLQQSHPL--------------------SATQ 331
                ++   +   DKV    K   A+   LQ   P+                    S TQ
Sbjct: 5021 TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQ 5080

Query: 332  IQVKREE---LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
            I+ K      L++ W+Q+  LA ER  +LND+      L +F +    +   K +   + 
Sbjct: 5081 IETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNH 5140

Query: 389  LASDVAGAEALLDRHQEHK 407
              S V      +D+ Q+ K
Sbjct: 5141 KKSRVMDFFRRIDKDQDGK 5159



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 64/276 (23%), Positives = 114/276 (41%), Gaps = 12/276 (4%)

Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
           +DL +WV EM+  ++  E  SD+   E+ L+ H+     I+  E S K A  S   + A 
Sbjct: 638 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 697

Query: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
                    EKL  L  + A LL      R Q      L  F         W++++E   
Sbjct: 698 ---LKLTYAEKLHRLESQYAKLL---NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 751

Query: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
           +  D  +   ++      H +  + L  +EE I ++ E A +L+  NH A   +   R A
Sbjct: 752 VAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 811

Query: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK-DPSN--- 606
           + ++ + + +        + ++    +FF D+ E   ++   +K A    Y  D S+   
Sbjct: 812 MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL-RNLKDAIQRKYSCDRSSSIH 870

Query: 607 -LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDV 641
            L+  VQ+    + EL   +S I  L    + +I +
Sbjct: 871 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 906



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 22/279 (7%)

Query: 145 LLQAQKLVQYLRECE-------DVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTD 197
           LL++  L Q L E E       D+++W+++ +  +   E G DL  VE      E  +  
Sbjct: 617 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE---SHLENHKNV 673

Query: 198 MAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 257
             A EE  + + +     IQ   P +     K   + + + +L   +  ++  L     +
Sbjct: 674 HRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTL 730

Query: 258 QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAE 317
             F       + W+ EKE+   + D+     ++      H  L R+L   E+ +K++   
Sbjct: 731 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 790

Query: 318 ADR-LQQSHPLSATQIQVKREELITNWEQIRTL--AAERHARLNDSYRLQRFLADFRDLT 374
           A++ L ++HP   T I+  R  + T W  I  L    E+H + N +Y    F  D ++ T
Sbjct: 791 AEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQCVEQHIKENTAY--FEFFNDAKEAT 847

Query: 375 SWVTEMKALIN---ADELASDVAGAEALLDRHQEHKGEI 410
            ++  +K  I    + + +S +   E L+    E K E+
Sbjct: 848 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 886


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  278 bits (711), Expect = 5e-74
 Identities = 415/1966 (21%), Positives = 824/1966 (41%), Gaps = 178/1966 (9%)

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASET--IRTRLMELHRQ 130
            +D   LQ + +  +AF  +++A   +    ++T  +M++    + +   I+  L  L +Q
Sbjct: 3156 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 3215

Query: 131  WELLLEKM--REKGIK--LLQAQKLVQYLRECEDVMDWINDKEAI-----VTSEELGQDL 181
               LL++   RE+ ++  + + ++    L+E   ++    + E       + +E + Q L
Sbjct: 3216 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 3275

Query: 182  EHVEVLQKKFEEFQTDMAAHEERVNEVNQ----FAAKLIQEQHPEEELIKTKQDEVNAAW 237
               +V QK  EE +  +   ++ VN + Q     AAK    Q  E +L     D+VNA W
Sbjct: 3276 NMFKVFQK--EEIEP-LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL-----DDVNARW 3327

Query: 238  QRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLR 295
            + L     QR  +L  A     RF   ++  +SW+ + E+L+A+      +   V+A ++
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3387

Query: 296  KHEGLERDLAALEDKVKALCAEADRLQQS-HPLSATQIQVKREELITNWEQIRTLAAERH 354
            + + L+R L   +  V+ +  E +++  +  P    +I  +   L + WE +   A  R+
Sbjct: 3388 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3447

Query: 355  ARLND-SYRLQRFLADFRDLTSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDA 412
             +L   S   Q+F      L  W+T + K L+N + + +  +  E  + +H+  + +I  
Sbjct: 3448 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3507

Query: 413  HEDSFKSADESGQAL-LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-DLQ 470
            H      A   GQ+L + +     D V+ KL         + E    R +  +Q + + +
Sbjct: 3508 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3567

Query: 471  LFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLSAQEEKITAL 526
            +F  D  ++ NW+++    L    + D   S E L K+  +     E  L  ++    AL
Sbjct: 3568 IFGEDEVELMNWLNEVHDKLSKLSVQDY--STEGLWKQQSELRVLQEDILLRKQNVDQAL 3625

Query: 527  DEFATKLIQNNHYAMEDVATRRDALLSRRNALHE------RAMRRRAQLADSFHLQQFFR 580
                  L Q     +  +  + +A+ +R   + +      + + +  QLA   H      
Sbjct: 3626 LNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTH--- 3682

Query: 581  DSDELKSWVNE---KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
              +EL +W+++   ++ +   +  K     Q +++  +  + E   N++ +D+L +    
Sbjct: 3683 --EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNEVSSA 3739

Query: 638  LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN--QQQQFNRNVEDIELWLY 695
            L+++  +   E   +M    +   +L+  T  + ++  +A   + QQF++  +    W+ 
Sbjct: 3740 LLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT 3799

Query: 696  EVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA-GHFD 751
            E E  L S       +D T+ Q   +K   +E  +  H+D ID +     +   A    +
Sbjct: 3800 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHKIMTACSEEE 3857

Query: 752  AENIKKKQEALVARYEALKEPMVARKQKL--ADSLRLQQLFRDVEDEETWIREKEPIAAS 809
             +++KKK + ++  Y+ + +    R  +L  A SL + Q +   E+   W+ E + I + 
Sbjct: 3858 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETYEELWPWLTETQSIISQ 3916

Query: 810  TNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
                  +   ++   ++H+ L+  IA H+P I  + + G  ++E        ++ K    
Sbjct: 3917 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA 3976

Query: 869  NQKWEALKAKASQRRQDLEDSLQAQQYFADANEA--ESWMREKEPIVGSTDYGKDEDSAE 926
            +  +  +K    +R   L++++     F D  +   ES  R  E +        + +  +
Sbjct: 3977 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4036

Query: 927  ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ----EKS 982
              + +++ +  D+       + L+++ +    +   TD +   + V    D      E  
Sbjct: 4037 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4096

Query: 983  PREVTMKKGDILTLLNSTNKDWWK-----VEVNDRQGFVPAAYVKKLDPA----QSASRE 1033
               V  ++  +L ++    K W       V + D Q F+       +DP+    Q  + E
Sbjct: 4097 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4156

Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVS------LRMKQVEEL---YHSLLELGEKRK 1084
             + EE   +   QE++D    +  E  +        +  K ++EL   + SL +  + R 
Sbjct: 4157 TIREEIDGL---QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4213

Query: 1085 GMLEKSCKKFMLFREANE-LQQWINEKEAALTS-EEVGADLEQVEVLQKKFDDFQKDLKA 1142
              LE++ +  + +++  + +  W++     L S   +G DLE V+   ++   F+ +   
Sbjct: 4214 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4273

Query: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
             +  ++ +N  AE      L+ ++V              +E+D              HTV
Sbjct: 4274 QQIEMERLNHQAE------LLLKKVT-------------EESDK-------------HTV 4301

Query: 1203 ATFNSIKELNERWRSLQQ-LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN- 1260
               + + EL   W SL++ +   + +L G+   + +F    DE   W+      L+    
Sbjct: 4302 Q--DPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4359

Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTELNQ 1319
             G D  +++    KH   + D+ A    V ++ +    LI+S   E A +LQ K   LNQ
Sbjct: 4360 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4419

Query: 1320 AWSSLGKRADQRKAKL-GDSHDLQRFLSDFRDLMSWINGI-RGLVSSDELAKDVTGAEAL 1377
             W ++ ++ +QRK +L G     + F  +  DL  W+    R L++S  L      A+  
Sbjct: 4420 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4479

Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQ 1436
            L  H E     +A+  T+++  Q GQQ+LA     A   I Q ++ L ++   +E    +
Sbjct: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539

Query: 1437 RRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAI 1494
            R+  L++ L L + FH   +   NW+   E  LN   +    LD+V   I +H+ F   +
Sbjct: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599

Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRN---EVLDRWRRLKAQMIEKRSKLGESQ 1551
            N   E+I  L      L       K D+   +N    V  RW ++  +++E+   L +++
Sbjct: 4600 NSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4657

Query: 1552 T-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
               +QF     ++  W+  SEK   +  E   DP  I+    L++H++ Q      H+  
Sbjct: 4658 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ--LAQHKEFQKSLGAKHSVY 4715

Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK-QQN 1667
            D        G SL E+ + A     +   L+ L D+W  +  KS E+  KL+EA      
Sbjct: 4716 DTTNRT---GRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4772

Query: 1668 FNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
            F   ++    WL  VE  LA +   +G D+  V NL+  H+  + ++      ++ L   
Sbjct: 4773 FTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4831

Query: 1726 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR--------LHQFFRD 1777
            A  L+  S  D+S VK +   ++ R++ + +++ S++ +L  + R        +H     
Sbjct: 4832 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4891

Query: 1778 MDDEESWIKEKKLLVGSEDYGRDLTGV-QNLRKKHKRLEAELAAHEPAIQGVL-----DT 1831
            + + E  ++   +L   ED  R L    +   KK +   AEL         VL     D+
Sbjct: 4892 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 4951

Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA---ARGQRLEESLEYQQFVANVEEEE 1888
               +    TI +   ++ LA   +H + L    A   A+ + LE  L + Q         
Sbjct: 4952 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQ--------- 5002

Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
             W    +T    E     +  ++ L+ +H+ F  + T  +  V+ V
Sbjct: 5003 -WAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5047



 Score =  265 bits (676), Expect = 5e-70
 Identities = 503/2529 (19%), Positives = 1024/2529 (40%), Gaps = 298/2529 (11%)

Query: 49   FQRDAEELEKWIQEKLQIASDENYKDPTN-----LQGKLQKHQAFEAEVQANSGAIVK-L 102
            FQ+ + + + W+  K +   ++N   P +     L+  ++ H+ F   + A S    K +
Sbjct: 2805 FQQMSRDFQAWLDTKKE---EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2861

Query: 103  DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA-QKLVQYLRECEDV 161
             E  NL++         ++ +L  +   W+   ++++E+  KL ++ +K ++Y  + E +
Sbjct: 2862 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2921

Query: 162  MDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
              WI+  +  +   +   D    E    K +  Q +M  H   V  +N  A  L+     
Sbjct: 2922 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2981

Query: 222  EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE-----KEQ 276
            ++E++    DE  +  Q++  +  Q   K F    + +  ++  E     K      KEQ
Sbjct: 2982 DKEVVT---DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQ 3038

Query: 277  LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
            L   D  G    S    L   +  ++ L AL+ +V      A RL Q   + A+  +   
Sbjct: 3039 LDIHDSLGSQAYS-NKYLTMLQTQQKSLQALKHQVDL----AKRLAQDLVVEASDSKGTS 3093

Query: 337  EELITNWEQIRTLAAERHARLNDSY---------RLQ---RFLADFRDLTSWVTEMKALI 384
            + L+    Q+ T+A E H+ L+            +LQ    F    R++ S   E    +
Sbjct: 3094 DVLL----QVETIAQE-HSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDEL 3148

Query: 385  NADELASDVAGAEALLDRHQEHKG---EIDAHEDSFKSADESGQALLAAGHYASDEV--R 439
              D +A     AE L  + +  K    +++A   S  +A+++ + +LA    + D V  +
Sbjct: 3149 --DSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3206

Query: 440  EKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDTEQVDNWMSKQEAFLLNED-LGD 497
              L  LS++   LL+  + R +Q E  +  L+ FY   ++    + K E    ++  +G 
Sbjct: 3207 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 3266

Query: 498  SLDSVEALLKKHEDFEKS----LSAQEEKITALDEFATKLIQNNHYAMEDVATRR----- 548
              +++   L   + F+K     L  +++ +  L +    LIQ+   A +  +T+      
Sbjct: 3267 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ---GLIQS---AAKSTSTQGLEHDL 3320

Query: 549  DALLSRRNALHERAMRRRAQLADSF-HLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN- 606
            D + +R   L+++  +R AQL ++  H  +F    + L SW+ +  +   ++  K PS  
Sbjct: 3321 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ--KPPSAE 3378

Query: 607  ---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA-KDEVAARMNEVISLWKK 662
               ++ ++Q+ +  +  L   +S ++ +++ G+K+      A K ++  +++ + S W+ 
Sbjct: 3379 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3438

Query: 663  LLEATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLAS-DDYGKDLTNVQNLQKKH 720
            LL   E +  +L   +   QQF+  +E +  WL  +E  L + +  G   + ++    +H
Sbjct: 3439 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3498

Query: 721  ALLEADVAAHQDRI-DGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
              LE D+  H   +   ++I       +   D + ++ K +     Y  ++E   +R + 
Sbjct: 3499 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3558

Query: 780  LADSLRLQQLFRDVEDE-ETWIRE-KEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHE 837
            L  +L   ++F + E E   W+ E  + ++  + +     G+     + + LQ +I   +
Sbjct: 3559 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3618

Query: 838  PRIKAVTQKGNAMVEEGHFAAEDV---KAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQ 893
              +      G  ++++     ++V   + KL  +  +++ +   ++   + LE +LQ A+
Sbjct: 3619 QNVDQALLNGLELLKQT--TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3676

Query: 894  QYFADANEAESWMR--EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
            +  +   E  +W+   E E +   T   K E++++A ++  E L  +     + + +L E
Sbjct: 3677 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNE 3735

Query: 952  QAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVND 1011
               S   ++ P     G E ++A              +  +   L++ T     KVE  D
Sbjct: 3736 -VSSALLELVPWRAREGLEKMVA--------------EDNERYRLVSDTITQ--KVEEID 3778

Query: 1012 RQGFVPAAYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITK------------ 1057
                    + +  D   S     E  L   G I L Q+Q   Q ++ K            
Sbjct: 3779 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3838

Query: 1058 ------------------EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
                              E  S+  ++ +V + Y ++ ++  +R   LE++      F E
Sbjct: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3898

Query: 1100 A-NELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL 1157
               EL  W+ E ++ ++     A + E +   Q++    ++ +  ++  +  +NK    L
Sbjct: 3899 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3958

Query: 1158 ----ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNE 1213
                  EG   +E + V    +Y  +  D              +    VA   +I +  +
Sbjct: 3959 LELSPGEGFSIQE-KYVAADTLYSQIKED--------------VKKRAVALDEAISQSTQ 4003

Query: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
                + Q+ E   +++    +      + ++ KE I E        N   D+  +Q L  
Sbjct: 4004 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK------NVSVDMEKLQPLYE 4057

Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
                    L   G+++ +     ++ I     SA+ +Q+K  ++   W ++    ++R+A
Sbjct: 4058 T-------LKQRGEEMIARSGGTDKDI-----SAKAVQDKLDQMVFIWENIHTLVEEREA 4105

Query: 1334 KLGDSHDL-QRFLSDFRDLMSWINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDAR 1391
            KL D  +L ++F  D   L+  I   +  +   ++   D +  +   E  +  R EID  
Sbjct: 4106 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 4165

Query: 1392 AGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
                      G +L+A  G    P +K+ +D L+     L KAW  R   L++ ++  + 
Sbjct: 4166 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 4225

Query: 1451 HRDCEQAE-NWM-AAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508
            ++D  QA  +W+  A     +    G  L++V+  I++ + F      Q+ ++  L   A
Sbjct: 4226 YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQA 4285

Query: 1509 DQLI--AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEA 1565
            + L+        K  +     E+   W  L+ ++I ++ KL G    L QF   +DE+ A
Sbjct: 4286 ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 4345

Query: 1566 WIS--EKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1623
            W++  E L +       DP  I++        KH   + ++ A+   +  V   GN LIE
Sbjct: 4346 WLTHTEGLLSEQKPVGGDPKAIEIELA-----KHHVLQNDVLAHQSTVEAVNKAGNDLIE 4400

Query: 1624 RGACAGSEDA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSE 1681
              + AG E + ++ +L  L  +WQ +++K+ ++ Q+L  A +Q + F+  I+D   WL++
Sbjct: 4401 --SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4458

Query: 1682 VEA-LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDT-SQ 1739
             E  LLAS+  G    +    L  H  + A   A E+  K L  +   ++        + 
Sbjct: 4459 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4518

Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLH-QFFRDMDDEESWIK--EKKLLVGSED 1796
            +    + +  +++ +++    R+ KL E+  L  +F   + D  +W+   E+ L V S  
Sbjct: 4519 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4578

Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE---IQQRLAQF 1853
                L  V     +HK    E+ +H   I  +  TG  L   +   K++   I+  L   
Sbjct: 4579 -SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISV 4635

Query: 1854 VEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQ 1911
               W+++ Q    RG+ L+++ +  +QF     +   W+ E    + SE +  +    I+
Sbjct: 4636 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4695

Query: 1912 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENIS--SKMKGLNGKVSDLEKA 1969
              L +H+ F+          +     G+ L +K +  ++N+     +  L  K   +   
Sbjct: 4696 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4755

Query: 1970 AAQRKAKLDENSAFL-QFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTKQETF 2026
            + +R+ KL+E   F  QF      +  W+   E  L  D   +G D+  V  L+   + F
Sbjct: 4756 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAF 4814

Query: 2027 DAGLQAFQQEGIANITALKD---QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKK 2083
               L     +  +++ ALK    +L+      S  ++ +   L  RW  + A S +++ +
Sbjct: 4815 QKELG----KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4870

Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLT-DPVRCNSLEEIKALREAHDAFR 2142
            L   ++  R+ E+    F     A   W   AE+ L    V  +  + ++ L + H  F 
Sbjct: 4871 L---EAALRQAEE----FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4923

Query: 2143 SSLSSAQADFNQLAELDRQIKSFRVASNPYT---WFTM------EALEETWRNLQK---- 2189
              L   +A+ N+   +   + +     +  T   W T+      E L    ++ Q+    
Sbjct: 4924 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4983

Query: 2190 ----IIKERELELQKEQRRQEEN---DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEE 2242
                I K+  LE      +  E    DK ++   Q        I E +T++ +   M  +
Sbjct: 4984 LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEE---MTRK 5040

Query: 2243 SGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVG-------- 2294
               ++   +  KR+  +  +++S +  + D G A  +     + Y   S           
Sbjct: 5041 QPDVDKVTKTYKRRAADPSSLQSHIPVL-DKGRAGRKRFPASSLYPSGSQTQIETKNPRV 5099

Query: 2295 --LAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM---------------- 2336
              L  +W Q+  L +  +  L   +          E L+EF+                  
Sbjct: 5100 NLLVSKWQQVWLLALERRRKLNDALDRL-------EELREFANFDFDIWRKKYMRWMNHK 5152

Query: 2337 -------FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2389
                   F+  DKD+ G++  QEF   + S  +    +       E  A+ D  D + DG
Sbjct: 5153 KSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL-------EMSAVADIFDRDGDG 5205

Query: 2390 HVSLQEYMA 2398
            ++   E++A
Sbjct: 5206 YIDYYEFVA 5214



 Score =  233 bits (594), Expect = 2e-60
 Identities = 446/2453 (18%), Positives = 976/2453 (39%), Gaps = 266/2453 (10%)

Query: 21   QVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIAS--DENYKDPTN 77
            ++  ++    +L+  R+QKLE+S      FQ    +L++W+ EK  + S       DP  
Sbjct: 2555 EIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2614

Query: 78   LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTRLMELHRQWELL 134
            L  + Q+ Q    E         +L   G  ++S   E       ++ +L  + ++W+ L
Sbjct: 2615 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2674

Query: 135  LEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSEE-LGQDLEHVE 185
              ++ ++        +K  Q Q L++ L +   D+ + ++   A+ T  + + Q LE  +
Sbjct: 2675 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2734

Query: 186  VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNA---AWQRLKG 242
             ++++ ++ +  +   +    +++     L++E++ + EL +  +  + +     Q+ + 
Sbjct: 2735 KMKQEIQQEKKQIKVAQALCEDLSA----LVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2790

Query: 243  LALQRQGKLFGAAEVQRFNRDVDETISWIK-EKEQLMASDDFGRDLASVQALLRKHEGLE 301
                 Q     + + Q+ +RD     +W+  +KE+   S      L  +++L++ H+   
Sbjct: 2791 HVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2847

Query: 302  RDLAALEDKVKALCAEADRL---QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLN 358
            + L A     +   AE + L    Q    +A Q+Q+    + TNW+       ER  +L 
Sbjct: 2848 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT--IKTNWDTFNKQVKERENKLK 2905

Query: 359  DSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSF 417
            +S  +  ++      L  W+ + +  +   +   D A  E  + + +  + E+D H    
Sbjct: 2906 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2965

Query: 418  KSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQ---CMD-LQLFY 473
            +  + +  +LL+      +       V+++E  +L++  ++  +Q      C++ +   +
Sbjct: 2966 ELLNNTANSLLSVCEIDKE-------VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3018

Query: 474  RDTEQVDNWMSKQEAFLLNE-DLGDSLDSVEALLKKH----EDFEKSLSAQEEKITALDE 528
            ++ ++V     +Q      + D+ DSL S +A   K+    +  +KSL A + ++     
Sbjct: 3019 KEFQEVSKESKRQLQCAKEQLDIHDSLGS-QAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3077

Query: 529  FATKLI--QNNHYAMEDVATRRDALLSRRNALHERAMRR----RAQLADSFHLQQFFRDS 582
             A  L+   ++     DV  + + +    + L ++   +      +L    H Q   R+ 
Sbjct: 3078 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3137

Query: 583  DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVN 642
                +  ++++ +      +D   LQ + +  +AF  +L A  +  D   K  + ++   
Sbjct: 3138 FSQFAEFDDELDSMAPVG-RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATE 3196

Query: 643  HYAKDEVAARMN-EVISLW-KKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEG 699
              + D V  + + E +S    KLL+  + +  ++    ++ ++F   +++  + L + E 
Sbjct: 3197 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3256

Query: 700  HLASDD-YGKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQF--QDAGHFDAENI 755
            H  S    G +   + Q L       + ++   Q +   +    +      A     + +
Sbjct: 3257 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3316

Query: 756  KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-VEDEETWIREKEPIAASTNR-G 813
            +   + + AR++ L + +  R  +L ++L     F+D +E   +W+ + E + A+     
Sbjct: 3317 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS 3376

Query: 814  KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQK 871
             +   V+  +++ + LQ  +   +  ++ + ++G  +       A+ VK   +L  L+ +
Sbjct: 3377 AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSR 3435

Query: 872  WEALKAKASQRRQDLED-SLQAQQYFADANEAESWMREKEP-IVGSTDYGKDEDSAEALL 929
            WEAL  KA  R + LE  S+ AQQ+         W+   E  +V     G      E  +
Sbjct: 3436 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3495

Query: 930  KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMK 989
             +H+AL  D+  +   +     QA S  Q +        K++V +  D+ +    E+  K
Sbjct: 3496 AQHKALEDDIINHNKHLH----QAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3551

Query: 990  KGDILTLLNST-------NKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
                  LL           +D      W  EV+D+        + KL   Q  S E L +
Sbjct: 3552 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK--------LSKLS-VQDYSTEGLWK 3602

Query: 1038 EQGS-------IALRQEQID----NQTRITKEAGS-----VSLRMKQVEELYHSLLELGE 1081
            +Q         I LR++ +D    N   + K+        +  +++ ++  Y  + +L  
Sbjct: 3603 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3662

Query: 1082 KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV----GADLEQVEVLQKKFDDF 1136
                 LE++ +        +E L  W+++ E  L S E     G +  Q ++  K   + 
Sbjct: 3663 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK---EL 3719

Query: 1137 QKDLKANESRLKDINK--------------------VAEDLESEGLMAEEV-QAVQQQEV 1175
            +K+ K N++ L  +N+                    VAED E   L+++ + Q V++ + 
Sbjct: 3720 KKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDA 3779

Query: 1176 YGMMPRD-------------ETDSKTAS--------PWKSARLMV--------------- 1199
              +  +              ET+ K  S           SA+L V               
Sbjct: 3780 AILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3839

Query: 1200 -------HTVATFNSIKELNERWRSLQQL-----------AEERSQLLGSAHEVQRFHRD 1241
                   H + T  S +E     + L ++           +E   QL  +   V +F   
Sbjct: 3840 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3899

Query: 1242 ADETKEWIEEKNQALNT-DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI 1300
             +E   W+ E    ++       +  +++  Q +H      +A     ++ + +T  +L+
Sbjct: 3900 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3959

Query: 1301 QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRD--LMSWINGI 1358
            +  P     +QEK    +  +S + +   +R   L ++        D  D  L S    +
Sbjct: 3960 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4019

Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
              L     ++ +V   +  +  ++    +++     ++  +Q G++++A       +I  
Sbjct: 4020 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4079

Query: 1419 KL--DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN-WMAAREAFLNTEDKGD 1475
            K   D LDQ    +   W     ++++  E +L     E AE  W       +  +D  D
Sbjct: 4080 KAVQDKLDQ----MVFIWENIHTLVEE-REAKLLDV-MELAEKFWCDHMSLIVTIKDTQD 4133

Query: 1476 SLDSVE------ALIKKHEDFDKAIN-----VQEEKIAALQAFADQLIAAGHYAKGDISS 1524
             +  +E      +++K+ ++  + I      +QEE    +   ++ + A G   K  +  
Sbjct: 4134 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4193

Query: 1525 RRNEVLDRWRRLKAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS---EKLQTASDESYK 1580
              +E+   W  L     ++  KL E+ Q   Q+   +  +  W+     KL + S     
Sbjct: 4194 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----- 4248

Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
             P    L  +  + ++ + F++E +     +  +      L+++      +  V+  L  
Sbjct: 4249 -PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 4307

Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQN-FNTGIKDFDFWLSEVEALLASED-YGKDLASV 1698
            L   W  L ++   +  KL+ A      F   + +   WL+  E LL+ +   G D  ++
Sbjct: 4308 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367

Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGRFQKIKSM 1757
               L KH +L+ D+ AH+  ++ +N   + L+ SSA +  S +++K + +N R+Q +   
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427

Query: 1758 AASRRAKLNESHRLHQFFR-DMDDEESWIK--EKKLLVGSEDYGRDLTGVQNLRKKHKRL 1814
               R+ +L+ + R  + F  +++D + W+   E+ LL      G   T  + L   H  +
Sbjct: 4428 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV-HMEV 4486

Query: 1815 EAELAAHEPAIQGVLDTGKK-LSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
             A   A E   + ++  G++ L+      +  I Q +    E W+ ++     R  +LEE
Sbjct: 4487 CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4546

Query: 1874 SLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931
            +L    +F  ++++   W+ + + TL  +      L  +   + +H+ F  +   H++++
Sbjct: 4547 ALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQI 4606

Query: 1932 NDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWK 1989
             ++   G  L   +   +   I + +  +  +   + +   +R   LD+      QF+  
Sbjct: 4607 IELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEA 4666

Query: 1990 ADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT-----A 2043
               +  W+ E E SL ++ +   D   ++T L + + F   L A  +  + + T     +
Sbjct: 4667 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA--KHSVYDTTNRTGRS 4724

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            LK++   A    +  ++   + L  +W  +   S  R+ KL EA     +  D       
Sbjct: 4725 LKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL----- 4777

Query: 2104 KASAFNSWFENAEEDLTD--PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
               A   W    E  L +  PV    ++ +  L + H AF+  L    +    L    R+
Sbjct: 4778 --QALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834

Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANA 2221
            +       + +    M+ L   W  +  +   ++  L+   R+ EE       F    +A
Sbjct: 4835 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEE-------FHSVVHA 4887

Query: 2222 FHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
              +W+ E    L     + ++   L + ++  K   +++   R++L K   +G
Sbjct: 4888 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMG 4940



 Score =  226 bits (576), Expect = 2e-58
 Identities = 433/2280 (18%), Positives = 920/2280 (40%), Gaps = 246/2280 (10%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF-FQRDAEELEKWIQEKLQIASDENY- 72
            +Q +   +   +  F +    R  KL++S      ++   E L  WI +      +  + 
Sbjct: 2879 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2938

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
             DP   +  + K ++ + E+  + G +  L+ T N ++S      E +      L ++ +
Sbjct: 2939 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2998

Query: 133  LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND-----KEAIVTSEELGQDL---EHV 184
            ++ E++  K   L   + + Q  +E ++V           KE +   + LG      +++
Sbjct: 2999 MVTEQLHSKKFCL---ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3055

Query: 185  EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL------IKTKQDEVNAAWQ 238
             +LQ +    Q  + A + +V+   + A  L+ E    +        ++T   E +   Q
Sbjct: 3056 TMLQTQ----QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3111

Query: 239  RLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ------- 291
            ++       + KL G    Q   R++    +   ++   MA    GRD  ++Q       
Sbjct: 3112 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP--VGRDAETLQKQKETIK 3169

Query: 292  ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR--EELITNWEQIRTL 349
            A L+K E L     A  D     C      +++ P     + +KR  E L     ++   
Sbjct: 3170 AFLKKLEAL----MASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDR 3222

Query: 350  AAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEH-- 406
            A  R  ++  +  RL+ F +  ++ +  + + +      E +    G E      Q +  
Sbjct: 3223 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE----HEESQGPVGMETETINQQLNMF 3278

Query: 407  ----KGEIDAHEDSFKSADESGQALLAAGHYAS---------DEVREKLTVLSEERAALL 453
                K EI+  +   +  +  GQ L+ +   ++         D+V  +   L+++ A   
Sbjct: 3279 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA--- 3335

Query: 454  ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS-LDSVEALLKKHEDF 512
               +   Q  E  +    F    E + +WM   E  + N+    +    V+A +++ +  
Sbjct: 3336 ---QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL 3392

Query: 513  EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-SRRNALHERAMRRRAQLAD 571
            ++ L  ++  +  +     K+      A +    ++ +LL SR  AL  +A  R  QL  
Sbjct: 3393 QRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3452

Query: 572  -SFHLQQFFRDSDELKSWVN--EKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
             S   QQF    + L  W+   EK     +      S L+ ++ +H+A E ++  +   +
Sbjct: 3453 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3512

Query: 629  DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV- 687
                  GQ L  ++     ++     +   +W   +E  E K     E  QQ   N  + 
Sbjct: 3513 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW--YIEIQE-KSHSRSELLQQALCNAKIF 3569

Query: 688  --EDIEL--WLYEVEGHLAS---DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
              +++EL  WL EV   L+     DY  +   +   Q +  +L+ D+   +  +D   + 
Sbjct: 3570 GEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELRVLQEDILLRKQNVDQALLN 3627

Query: 741  ARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEE- 797
              +   Q  G  +   I+ K EA+ ARY+ + +      + L  +L+L +      +E  
Sbjct: 3628 GLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3686

Query: 798  TWIR--EKEPIAASTN--RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
            TW+   E E ++  T   +G++    Q   K+   L+ E   ++  + ++ +  +A++E 
Sbjct: 3687 TWLDKVEVELLSYETQVLKGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLEL 3743

Query: 854  GHFAA-EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE-SWMREKEP 911
              + A E ++  + E N+++  +    +Q+ ++++ ++   Q F  A +AE SW+ E E 
Sbjct: 3744 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3803

Query: 912  ---IVGSTDYGKDEDSAEALLKK--------HEALMSDLSAYGSSIQAL--REQAQSCRQ 958
                +G     +D+ SA+  ++K        H+ ++ DL   G  I      E+ QS ++
Sbjct: 3804 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3863

Query: 959  QVAPTDDETGKELVLALYDY--QEKSPREVTMKKGDILTLLNSTNKDW--------WKVE 1008
            ++         + VL  YD   Q  S R + +++   L      N+ W        W  E
Sbjct: 3864 KL---------DKVLKNYDTICQINSERYLQLERAQSLV-----NQFWETYEELWPWLTE 3909

Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITK--------EAG 1060
                   +PA  ++     Q       L E   IA  +  ID   +           E  
Sbjct: 3910 TQSIISQLPAPALEYETLRQQQEEHRQLREL--IAEHKPHIDKMNKTGPQLLELSPGEGF 3967

Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVG 1120
            S+  +    + LY  + E  +KR   L+++  +   F +  ++ Q +       + E + 
Sbjct: 3968 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILE------SLERIV 4019

Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQ---QQEVYG 1177
              L Q   +  + +  ++ +  N++   D+ K+    E+     EE+ A      +++  
Sbjct: 4020 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4079

Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAE----ERSQLLGSAH 1233
               +D+ D      W++    +HT+     ++E   +   + +LAE    +   L+ +  
Sbjct: 4080 KAVQDKLDQMVFI-WEN----IHTL-----VEEREAKLLDVMELAEKFWCDHMSLIVTIK 4129

Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
            + Q F RD ++                 G D + V+  Q   E    ++  L ++++ + 
Sbjct: 4130 DTQDFIRDLEDP----------------GIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4173

Query: 1294 ETAERLIQSHPESAEDLQEKCT-ELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
                 LI +  E  + + +K   ELN AW SL K    R  KL ++     ++    + +
Sbjct: 4174 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4233

Query: 1352 MSWINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
              W++   G L S   +  D+   +  +E  ++ ++E   +    +      + LL    
Sbjct: 4234 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4293

Query: 1411 YASPE--IKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAF 1467
              S +  ++  L  L      LE+  + R+  L+  L  L  F    ++   W+   E  
Sbjct: 4294 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4353

Query: 1468 LNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
            L+ +   G    ++E  + KH      +   +  + A+    + LI +    +      +
Sbjct: 4354 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4413

Query: 1527 NEVLD-RWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEAWISE--------KLQTASD 1576
             EVL+ RW+ +  +  +++ +L G  +  + F  ++++++ W+++        K      
Sbjct: 4414 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4473

Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS-EDAVK 1635
            E+ K+  N+           H    A   A  +  + ++  G  ++ R  C  S E  + 
Sbjct: 4474 ETAKEQLNV-----------HMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNID 4520

Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALL-ASEDYGK 1693
              +  L ++W+ +  K  E+  KL+EA N    F+  ++DF  WL++ E  L  +     
Sbjct: 4521 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSL 4580

Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQ 1752
             L +V   + +H++   ++++H +++ +L+     L   S   D   +K+   ++  R++
Sbjct: 4581 ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWE 4640

Query: 1753 KIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTGVQNLRKK 1810
            K+      R   L+++  R  QF         W++E +  + SE +   D   ++    +
Sbjct: 4641 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4700

Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ--QRLAQFVEHWKELKQLAAARG 1868
            HK  +  L A          TG+ L +  ++  + ++    L++  + W  +   +  R 
Sbjct: 4701 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4760

Query: 1869 QRLEESLEYQ-QFVANVEEEEAWINEKMTLVASED--YGDTLAAIQGLLKKHEAFETDFT 1925
             +LEE+L +  QF   ++    W+      +A +   +GD +  +  L+  H+AF+ +  
Sbjct: 4761 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELG 4819

Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ 1985
                 V  +  + ++LI+ +      +  +M+ L+ +   +   +  ++ +L+  +A  Q
Sbjct: 4820 KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLE--AALRQ 4877

Query: 1986 FNWKADVVES---WIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
                  VV +   W+ E E +L+       D  +++TL+ + + F   L+  + E +   
Sbjct: 4878 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAE-LNKA 4936

Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMK-RWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
            T + D +LA  H  S        ++++ R+ ++LA +   +++L  A +     ++L   
Sbjct: 4937 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL-- 4994

Query: 2101 FAKKASAFNSWFENAEEDLTDP---VRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
                  A  +W + AE  LTD    V    +EE+KAL   H  F   ++  Q D +++ +
Sbjct: 4995 -----EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5049



 Score =  188 bits (477), Expect = 6e-47
 Identities = 502/2586 (19%), Positives = 1010/2586 (39%), Gaps = 326/2586 (12%)

Query: 14   DIQERRQ---QVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEEL-EKWIQEKLQIAS 68
            ++ E+RQ    + D   + K +S  + +   E    F + +  A++L E+W    +QI  
Sbjct: 1261 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI-- 1318

Query: 69   DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
            D   +D   L+G  +  + +          I +++ T   +       S+T+ T+L    
Sbjct: 1319 DNRLRD---LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---- 1371

Query: 129  RQWELLLEKMREKGIKLLQAQKLV-QYLRECEDVMDWINDKEAIVTSEELG-----QDLE 182
             Q ++L+ ++  K  K+ + QK   QY    +D         A+V S++       +   
Sbjct: 1372 NQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQS 1431

Query: 183  HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE-LIKTKQDEVNAAWQRLK 241
              +++ ++F + +T   A    + +  +FA   ++    EE+ L + K++ V  A +  K
Sbjct: 1432 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1491

Query: 242  GLA-LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH--- 297
             ++ + +  K    A    F++    +     +KEQL  +      L ++Q  L KH   
Sbjct: 1492 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEA------LQTIQLFLAKHGDK 1545

Query: 298  ------EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
                    LE+ +  L++    L +E+ +  Q    S T   VK EE I          A
Sbjct: 1546 MTDEERNELEKQVKTLQESYNLLFSESLKQLQE---SQTSGDVKVEEKIV---------A 1593

Query: 352  ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
            ER          Q +    + +   +T+ +  +   + A  +      L ++Q  + E+ 
Sbjct: 1594 ERQ---------QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1644

Query: 412  AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
                  K    S QAL        + ++E    LS+E  AL+E  +   +   +C  L L
Sbjct: 1645 ------KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKIKCEQLNL 1696

Query: 472  FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
                 EQ     SK+E           LD V     K E  + +   Q E+     E   
Sbjct: 1697 ---KAEQ-----SKKE-----------LDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1737

Query: 532  KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
              + N     E   T+   ++ + N  H +    ++ + +   +     ++D +   V  
Sbjct: 1738 DWLSNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGEEDEVNGNLLETD-VDGQVGT 1795

Query: 592  KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA 651
              +    +  K  +  +  + +HQA    + A QS    LEK GQ L   +   K+++  
Sbjct: 1796 TQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYL---SPEEKEKLQK 1849

Query: 652  RMNEVISLWKKLLEATELKGIKLREANQQQ--QFNRNVEDIELWLYEVEGHLASDDYGKD 709
             M E+   ++  L  +E K +KL  + Q++  +F+ +  + E WL + E  L + + G D
Sbjct: 1850 NMKELKVHYETALAESEKK-MKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1908

Query: 710  -LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF---------QDAGHFDAE----NI 755
             +  +    K+      DV +H+  +  ITI   +          +D G  D       +
Sbjct: 1909 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1968

Query: 756  KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED---------EETWIRE-KEP 805
            ++K +    R+ +L          L D +   Q + D            E T  +   EP
Sbjct: 1969 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2028

Query: 806  IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGHF--AAEDVK 862
            IA       D   +Q  L++ +ALQ +I+  +  ++ + +    +++  G    A  D++
Sbjct: 2029 IAV------DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2082

Query: 863  AKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA-NEAESWMREKEPIVGSTDYGKD 921
              L ++  ++E L    ++R + L+ +L       D  +E   WM   E  +        
Sbjct: 2083 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2142

Query: 922  EDSA-EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
              +A + ++ K+  L  D++   SSI A+ E+ +   +    TD  T   L   + D   
Sbjct: 2143 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET---TDPSTASSLQAKMKDLSA 2199

Query: 981  KSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG 1040
            +   E + K  + L  +        KVE+ +          +KL        + L E   
Sbjct: 2200 RFS-EASHKHKETLAKMEELKT---KVELFENLS-------EKLQTFLETKTQALTE--- 2245

Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE------LGEKRKGMLEKSCKKF 1094
             + +  + +   ++  +E+ S  L  K+  E+ HSLL+      L   +  +LEK+    
Sbjct: 2246 -VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNN-- 2302

Query: 1095 MLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK------ 1148
             L ++  E++  I EK+ A+TS +    L+  +VL K    + K+       ++      
Sbjct: 2303 -LSKKFKEMEDTIKEKKEAVTSCQ--EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2359

Query: 1149 DINKVAEDL----ESEGLMAEEVQAVQQQEVY--GMMPRDETDSKTASPWKSARLMVHTV 1202
            D+ K  ED     E   L   E+Q V    +    ++    T +K  +  KS   +++  
Sbjct: 2360 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2419

Query: 1203 ATFNSIKEL--NERWRSLQQ---------------LAEERSQLLGSAHEVQRFHRDADET 1245
             T  + +E   N+   S+++               L ++ ++L     ++Q+   ++   
Sbjct: 2420 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2479

Query: 1246 KEWIEEKNQALNTDNYGH---DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
             +W+++ N+            D  +V+    +++ FE +L    +KV  L +    L++ 
Sbjct: 2480 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2539

Query: 1303 HPESAEDLQEK--CTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIR 1359
            +P++ E  + K   TE++  W  L +    R+ KL +S ++L +F +    L  W+    
Sbjct: 2540 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2599

Query: 1360 GLVSS-DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
             +VS    L+ D        ++ Q    E   R   ++     GQ +L+      P ++ 
Sbjct: 2600 LMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG-EDPSLR- 2657

Query: 1419 KLDILDQERADLEKAWVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK--GD 1475
               I+ ++ A + + W      L D+C  +        Q ++ + +    L+  D     
Sbjct: 2658 --GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2715

Query: 1476 SL------DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAA--GHYAKGDISSRRN 1527
            SL      D++   ++  +   + I  ++++I   QA  + L A     Y K ++S +  
Sbjct: 2716 SLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLE 2775

Query: 1528 EVLDRWRRLKAQ----MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
             +L  ++ ++ +    +   +S    S   QQ SRD    +AW+  K +   +++   P 
Sbjct: 2776 GILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD---FQAWLDTKKE---EQNKSHPI 2829

Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA-VKARLAALA 1642
            + +L  L S  + H+ F   L A +      I  G +L+ +    GSE A ++ +L  + 
Sbjct: 2830 SAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEKAALQLQLNTIK 2887

Query: 1643 DQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
              W    ++  E+  KLKE+  K   +   ++    W+ + +  L    +  D A   N 
Sbjct: 2888 TNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENS 2947

Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
            + K + L+ ++  H   ++ LN+ A+SL++    D   V D+  ++  +   +     S+
Sbjct: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007

Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG-RDLTGVQNLRKKHKRLEAELAA 1820
            +  L    +  + F+++  E     +++L    E     D  G Q    K+  +      
Sbjct: 3008 KFCLENMTQKFKEFQEVSKES----KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK 3063

Query: 1821 HEPAIQGVLDTGKKLSDDNTI------GKEEIQQRLAQFVEHWKELKQLAAARGQRLEES 1874
               A++  +D  K+L+ D  +      G  ++  ++    +    L Q    +   LE  
Sbjct: 3064 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3123

Query: 1875 LE----YQQFVANVEEEEAWINEKMTLVA-----SEDYGDTLAAIQGLLKKHEAFETDFT 1925
            L+    +Q  +  +  + A  ++++  +A     +E        I+  LKK EA      
Sbjct: 3124 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS-- 3181

Query: 1926 VHKDRVNDVCT-------NGQDLI----------KKNNHHEENISSKMKGLNGKVSDLEK 1968
               D  N  C           DL+          K+ N   +   ++ + + G +  LE+
Sbjct: 3182 --NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE 3239

Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
              +    KL E S  LQ   KA+  E   G     ++T+   + L+  + +  K+E    
Sbjct: 3240 FYS----KLKEFSILLQ---KAEEHEESQGPV--GMETETINQQLNMFK-VFQKEEI--E 3287

Query: 2029 GLQAFQQEGIANITALKDQLL--AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE 2086
             LQ  QQ+    +  L   L+  AAK   ++ +E     +  RW  L    A R  +L E
Sbjct: 3288 PLQGKQQD----VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3343

Query: 2087 AQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP--------VRCNSLEEIKALREAH 2138
            A  H  + +D          +  SW  + EE + +         V    ++E K L+   
Sbjct: 3344 ALLHCGRFQDAL-------ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLL 3396

Query: 2139 DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELEL 2198
            D  +S++   + +  ++A         ++         +  L+  W  L    + R  +L
Sbjct: 3397 DDRKSTVEVIKREGEKIATTAEPADKVKILKQ------LSLLDSRWEALLNKAETRNRQL 3450

Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
                   E    + Q+F +     ++W+      L++   +  ++  LE Q+   K    
Sbjct: 3451 -------EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3503

Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQW-DQLDQLGMRMQHNLEQQI 2317
            +I      L +   +G +++     ++K    S +  +Q W  ++ +        L+Q +
Sbjct: 3504 DIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQAL 3563

Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEF--------KSCLRSLGYDLPMVEE 2369
                  G  E  L    M + +   DK  +L+ Q++        +S LR L  D+ + ++
Sbjct: 3564 CNAKIFGEDEVEL----MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3619

Query: 2370 GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAF-RALSSEGKPY 2428
                     +        D  + +Q+ +  + +R  +  K S ++     +AL    + +
Sbjct: 3620 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3679

Query: 2429 VTKEEL 2434
             T EEL
Sbjct: 3680 STHEEL 3685



 Score =  167 bits (423), Expect = 1e-40
 Identities = 206/996 (20%), Positives = 441/996 (44%), Gaps = 77/996 (7%)

Query: 1    MDPSGVKVLETAE----DIQERRQQVLDRYHRFKELSTLRRQKLED--SYRFQFFQRDAE 54
            M+ +G ++LE +      IQE+       Y + KE    R   L++  S   QF  +  +
Sbjct: 3951 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4010

Query: 55   ELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD----------E 104
             LE    E++     E  + P ++  +++K    + ++  N    V ++          +
Sbjct: 4011 ILESL--ERIV----ERLRQPPSISAEVEK---IKEQISENKNVSVDMEKLQPLYETLKQ 4061

Query: 105  TGNLMISEG-----HFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ------ 153
             G  MI+         +++ ++ +L ++   WE +   + E+  KLL   +L +      
Sbjct: 4062 RGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4121

Query: 154  --YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
               +   +D  D+I D E      + G D   V+  Q+  E  + ++   +E ++ V   
Sbjct: 4122 MSLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4175

Query: 212  AAKLIQE-QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETIS 269
             ++LI     P++ ++K   DE+N+AW  L      R  KL  A +   ++   +     
Sbjct: 4176 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4235

Query: 270  WIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLS 328
            W+      +AS    G DL +V+  + + +  + +    + +++ L  +A+ L +     
Sbjct: 4236 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4295

Query: 329  ATQ--IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALIN 385
            + +  +Q    EL   W+ +      R  +L  +   L +F     +L +W+T  + L++
Sbjct: 4296 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4355

Query: 386  ADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASDEVREKL 442
              + +  D    E  L +H   + ++ AH+ + ++ +++G  L+  +AG  AS+ ++ KL
Sbjct: 4356 EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN-LQNKL 4414

Query: 443  TVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLL-NEDLGDSLD 500
             VL++    +LE  E R+QQ +  +   + F+ + E +  W++  E  LL ++ LG   +
Sbjct: 4415 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4474

Query: 501  SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAME-DVATRRDALLSRRNALH 559
            + +  L  H +   +  A+EE   +L +   +++     + E ++    + L  +  ++ 
Sbjct: 4475 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4534

Query: 560  ERAMRRRAQLADSFHLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQG----KVQKH 614
             +   R+ +L ++ +L   F +S  +  +W+ +  +T        PS +      ++ +H
Sbjct: 4535 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN--VASRPSLILDTVLFQIDEH 4592

Query: 615  QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISL---WKKLLEATELKG 671
            + F  E+++++ +I  L+K G  L   +   K +V    N +IS+   W+K+++    +G
Sbjct: 4593 KVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERG 4650

Query: 672  IKLREANQQ-QQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNLQKKHALLEADVAA 729
              L +A ++ +QF+     +  WL E E  L S+ +   D   ++    +H   +  + A
Sbjct: 4651 RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA 4710

Query: 730  HQDRIDGITIQARQFQDAGHFDAENIKKKQ--EALVARYEALKEPMVARKQKLADSLRLQ 787
                 D      R  ++      +N+K       L  +++ +    V R+ KL ++L   
Sbjct: 4711 KHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4770

Query: 788  QLFRD-VEDEETWIREKEP-IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
              F D ++    W+   EP +A       D+  V NL+  H+A Q E+      ++A+ +
Sbjct: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830

Query: 846  KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAES 904
                ++E     +  VK ++ EL+ +WE + A +  ++  LE +L QA+++ +  +    
Sbjct: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890

Query: 905  WMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDL 939
            W+ E E  +        DED+   L+ +H+  M  L
Sbjct: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL 4926



 Score =  160 bits (405), Expect = 1e-38
 Identities = 484/2522 (19%), Positives = 976/2522 (38%), Gaps = 424/2522 (16%)

Query: 9    LETAEDIQERRQQVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA 67
            ++  E  Q + Q+  ++    K L+T L +QK+  S   +  Q   +E +K+ ++     
Sbjct: 1346 IQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVS-EIEMKQSKMDECQKYAEQYSATV 1402

Query: 68   SDENYKDPTN--LQGKLQKHQAFEAEVQANSGAIV--------KLDETGNLMISEGHFAS 117
             D   +  T   +    QK       +Q+++  I+        +      LM     FA 
Sbjct: 1403 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1462

Query: 118  ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLV----QYLRECEDV------MDWIND 167
            ++++     L  + + L E+ +E   K  + QK V    + L++ E           I+ 
Sbjct: 1463 DSLK----RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1518

Query: 168  KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE---------ERVNEVNQFAAKLIQE 218
            +E     E+L + L+ +++   K  +  TD   +E         E  N +   + K +QE
Sbjct: 1519 EEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1578

Query: 219  QHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
                     EE+++  +Q E     Q +  L  Q + +L G  E         E   +  
Sbjct: 1579 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1638

Query: 273  EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
            ++E+L   D  G   A  + +      L+ +   L  + KAL  +  +L ++  +   Q+
Sbjct: 1639 KQEELQ-KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ--KLNEAK-IKCEQL 1694

Query: 333  QVKREELITNWEQIRTLAA-ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELAS 391
             +K E+     +++ T A  E   ++    +L+       +L  W++      N D+  S
Sbjct: 1695 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DS 1747

Query: 392  DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
            + AG +        HK  I+ +   F+  D  G++ +       DEV   L + ++    
Sbjct: 1748 ERAGTK--------HKQVIEQNGTHFQEGD--GKSAIGE----EDEVNGNL-LETDVDGQ 1792

Query: 452  LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
            +    E   QQY++            Q +  +S+ +A ++      +  S + LL+K   
Sbjct: 1793 VGTTQENLNQQYQKVK---------AQHEKIISQHQAVII------ATQSAQVLLEKQGQ 1837

Query: 512  FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
            +   LS +E++         KL +N    M+++    +  L+      E+ M+    L +
Sbjct: 1838 Y---LSPEEKE---------KLQKN----MKELKVHYETALAES----EKKMKLTHSLQE 1877

Query: 572  SFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSN-LQGKVQKHQAFEAELSANQSRID 629
               L++F  D  E + W+ +  +   + EA  D  N L  K+++ ++F  ++ +++  + 
Sbjct: 1878 E--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1935

Query: 630  ALEKAGQKLIDVNHYAKD-------------EVAARMNEVISLWKKLLEATELKGIKLRE 676
             +  +G ++++                    EV  +++     ++ L     + G  L++
Sbjct: 1936 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1995

Query: 677  ANQQQQFNRNVE-----DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
               + Q   +        ++        HL S+    D  N+Q   ++   L+  +++ Q
Sbjct: 1996 LVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQ 2054

Query: 732  DRIDGITIQARQFQDA--GHFDAEN-IKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
              ++ +   A    DA      A+N I+K  + +V RYE L + +  R +KL  +L    
Sbjct: 2055 VAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2114

Query: 789  LFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
              +D  DE        E+ ++E+  +  ++        +Q+++ K+  L+ +IAG +  I
Sbjct: 2115 SVQDGLDEMLDWMGNVESSLKEQGQVPLNST------ALQDIISKNIMLEQDIAGRQSSI 2168

Query: 841  KAVTQKGNAMVEEGH-FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA 899
             A+ +K    +E      A  ++AK+ +L+ ++     K  +    +E+     + F + 
Sbjct: 2169 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 2228

Query: 900  NEA-ESWMREKEPIVGSTDY-GKD---------EDSAEALL-KKH----EALMSDLSAYG 943
            +E  ++++  K   +   D  GKD         E ++E L  KKH     +L+ ++S++G
Sbjct: 2229 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 2288

Query: 944  -----------------------SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
                                    +I+  +E   SC++Q+     +  + LV +L  + +
Sbjct: 2289 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL-----DAFQVLVKSLKSWIK 2343

Query: 981  KSPREVTMKKG-----DILTLLNSTNK--DWWKVEVNDRQ-----GFVPAAYVKKLD-PA 1027
            ++ ++V + +      D+   L  T K  + W ++  + Q     G      +  +  PA
Sbjct: 2344 ETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPA 2403

Query: 1028 QSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGML 1087
            ++ +    ++  G++   +    N        G  S++ K + ++ H   +LG   K  +
Sbjct: 2404 KAIAA---VKSGGAVLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI 2459

Query: 1088 EKSCKKFMLFREANE----LQQWINEKEAALTSEE---VGADLEQVEVLQKKFDDFQKDL 1140
             +   K    ++A E    + QW+ +     T  +      D E V+   ++   F+ +L
Sbjct: 2460 AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2519

Query: 1141 KANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
            K N ++++++ +K+ E LE                       +  D+  A  WK      
Sbjct: 2520 KQNVNKVQELKDKLTELLE-----------------------ENPDTPEAPRWKQM---- 2552

Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIEEKN----- 1253
                    + E++ +W+ L QL  +R Q L  S++ + +F     + K+W+ EK      
Sbjct: 2553 --------LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2604

Query: 1254 --------QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPE 1305
                      LNT      +   +   RK + +E+  AA    ++  GE         P 
Sbjct: 2605 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQ-YEQLTAAGQGILSRPGED--------PS 2655

Query: 1306 SAEDLQEKCTELNQAWSSL----GKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
                ++E+   + Q W SL      R D     +  S   Q  L    D +S ++    L
Sbjct: 2656 LRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KL 2713

Query: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQL--LAHGHYASPEIKQK 1419
             SS  ++         LE  Q+ + EI       +  +   + L  L    Y   E+ ++
Sbjct: 2714 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2773

Query: 1420 LDILDQERADLE-KAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK-GDSL 1477
            L+ + +   D+E KA    + +   C     F +     + W+  ++   N        L
Sbjct: 2774 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2833

Query: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA-KGDISSRRNEVLDRWRRL 1536
            D +E+LIK H+DF K +  Q        A  + L+     + K  +  + N +   W   
Sbjct: 2834 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2893

Query: 1537 KAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS------EKLQTASDESYKDPTNIQLSK 1589
              Q+ E+ +KL ES +   ++   V+ +  WI       E+++   D +  + +  +L  
Sbjct: 2894 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2953

Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLI--ERGACAGSEDAVKARLAALADQWQF 1647
            L  +  +H      L+  A+ +  V ++   ++  E  +     D V  +L +     + 
Sbjct: 2954 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3013

Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQ 1706
            + QK  E  +  KE+ +Q        D       +   L S+ Y  K L  +    K  Q
Sbjct: 3014 MTQKFKEFQEVSKESKRQLQCAKEQLD-------IHDSLGSQAYSNKYLTMLQTQQKSLQ 3066

Query: 1707 LLEADISAHEDRLKDLNSQA-DSLMTSSA-FDTSQVKDKRDTINGRFQKIKSMAASRRAK 1764
             L+  +   +   +DL  +A DS  TS        +  +  T++   Q++    +    K
Sbjct: 3067 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS---QQVDEKCSFLETK 3123

Query: 1765 L-------NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ----NLRKKHKR 1813
            L       N    +   F + DDE         L      GRD   +Q     ++   K+
Sbjct: 3124 LQGIGHFQNTIREMFSQFAEFDDE---------LDSMAPVGRDAETLQKQKETIKAFLKK 3174

Query: 1814 LEAELAAHEPAIQGVLDTGKKL--SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1871
            LEA +A+++ A +    T K +  +++ +     I++ L    +   +L   A AR +++
Sbjct: 3175 LEALMASNDNANK----TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3230

Query: 1872 EESLE-YQQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQGLLKKHEAFE-TDFTVHK 1928
            E +++  ++F + ++E    + +      S+   G     I   L   + F+  +    +
Sbjct: 3231 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3290

Query: 1929 DRVNDVCTNGQDLIKK--NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
             +  DV   GQ LI+    +   + +   +  +N +   L K  AQR A+L E  A L  
Sbjct: 3291 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE--ALLHC 3348

Query: 1987 NWKADVVE---SWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT 2042
                D +E   SW+ + E  +        +   V+  + +Q+     LQ    +  + + 
Sbjct: 3349 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL----LQRLLDDRKSTVE 3404

Query: 2043 ALK---DQLLAAKHVQSKAIEARHASLM-KRWSQLLANSAARKKKL----LEAQSHFRKV 2094
             +K   +++        K    +  SL+  RW  LL  +  R ++L    + AQ     +
Sbjct: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3464

Query: 2095 EDL--FLTFAKKA---------------------SAFNSWFENAEEDLTDPVRCNSLEEI 2131
            E L  +LT  +K                       A      N  + L   V      ++
Sbjct: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3524

Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
             + RE  D  +S L     DF+Q+  ++ Q KS             E L++   N  KI 
Sbjct: 3525 LSSREDKDMVQSKL-----DFSQVWYIEIQEKSHS---------RSELLQQALCN-AKIF 3569

Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT------ 2245
             E E+EL       E +DKL +   Q  +    W Q++   +L    ++ +         
Sbjct: 3570 GEDEVELM--NWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3627

Query: 2246 ---------------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEH 2290
                           ++ +LEA K ++++I  + +      D+   +E+AL L  +   H
Sbjct: 3628 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST------DVAKTLEQALQLARRL--H 3679

Query: 2291 ST 2292
            ST
Sbjct: 3680 ST 3681



 Score =  112 bits (281), Expect = 3e-24
 Identities = 330/1819 (18%), Positives = 696/1819 (38%), Gaps = 265/1819 (14%)

Query: 669  LKGIKLREANQQQQFNRN-VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
            LK   L +   +++ N   V+D+  W+ E++  L   ++G DL +V++  + H  +   +
Sbjct: 629  LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 688

Query: 728  AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
               +  +    I   Q             +K   L ++Y  L      +++ L     L 
Sbjct: 689  EEFESSLKEAKISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQERHLDT---LH 742

Query: 788  QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
                   +E  W+ EKE    + +  +    +      H  L  E+   E  IK+V +  
Sbjct: 743  NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIA 802

Query: 848  NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
              ++ E H A   ++A    +  +W  +        Q ++++    ++F DA EA  ++R
Sbjct: 803  EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 862

Query: 908  EKEPIVG---STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
              +  +    S D        E L+++      +L  Y S+I  L  +A++  Q      
Sbjct: 863  NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 922

Query: 965  DETGKEL--VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV 1021
            D   K    + A+ DY++    E+T+ K D   L N++++  WKV      +  VP+   
Sbjct: 923  DCPLKTSIPIKAICDYRQ---IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCF 979

Query: 1022 KKLDPAQSA-SRENLLEE--QGSIALRQEQIDNQTRIT------------KEAGSVSLRM 1066
                P + A    N +E+  Q  + L  E   N   +             + +   S++ 
Sbjct: 980  TVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKT 1039

Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKK--------FMLFREANELQQWINEKEAALTSEE 1118
                E    L  L  + +  LE S +           L +E N  +Q+  E   +   EE
Sbjct: 1040 MLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREE 1099

Query: 1119 ------------------------------VGADLEQVEVLQKKFD-DFQKDLKANESRL 1147
                                          +   LE+ ++ +  F    Q+ LK    RL
Sbjct: 1100 QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL 1159

Query: 1148 KD----INKVAEDLESEGLMAEEVQAVQQQ---------EVYGM----MPRDETDSKTAS 1190
            KD    I    E+  S+   +  V  ++ +         +VY M    + + +T +    
Sbjct: 1160 KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 1219

Query: 1191 PWKSARLMVH-----------TVATFNSIKEL---NERWRS--------LQQLAEERSQL 1228
              ++A  +V             +A  N+I+ L    ++WRS           L +E  + 
Sbjct: 1220 NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 1279

Query: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
               + E+ + +++ D   +W +EK   L  + + +    +    R  EG  + L    D 
Sbjct: 1280 KAISDEMFKTYKERDLDFDWHKEKADQL-VERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1338

Query: 1289 VNSLG------ETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD- 1340
             + L       ET +R IQ + PE+++ L    T+LNQ    L    + +++K+ +    
Sbjct: 1339 YHPLDDWIQQVETTQRKIQENQPENSKTL---ATQLNQQ-KMLVSEIEMKQSKMDECQKY 1394

Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELA-----KDVTGAEALLERHQEHRTEIDARAGTF 1395
             +++ +  +D        R +V S + +     +  + A+ +++   + RT   A     
Sbjct: 1395 AEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1454

Query: 1396 QAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF----- 1450
              + +F          A   +K+    L++E   LE+   +++  +++  ELQ +     
Sbjct: 1455 TQYIKF----------AGDSLKR----LEEEEKSLEE---EKKEHVEKAKELQKWVSNIS 1497

Query: 1451 --HRDCEQA------ENWMAAREAFLNTEDKGDSLDSVEALIKKHED--FDKAINVQEEK 1500
               +D E+A      +  +++ E     E   ++L +++  + KH D   D+  N  E++
Sbjct: 1498 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1557

Query: 1501 IAALQAFADQLIAAG------HYAKGDISSRRNEVLDRWRRLKAQ-------MIEKRSKL 1547
            +  LQ   + L +            GD+      V +R +  K +       + +  ++L
Sbjct: 1558 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1617

Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASD---------ESYKDPTNI---------QLSK 1589
               Q          E++ + S++ +   D         E  K+  N          Q  K
Sbjct: 1618 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1677

Query: 1590 LLSKHQKHQAFE--AELHANADRIRGVIDMG-----NSLIERGACAGSEDAVKARLAALA 1642
             L + + ++A     +L+  A++ +  +D           E+ A     +  K ++  L 
Sbjct: 1678 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1737

Query: 1643 DQWQFLVQKSAEKS-QKLKEANKQQNFNTGIKDFDFWLSEVEA----LLASEDYGKDLAS 1697
            D W   V K +E++  K K+  +Q   +    D    + E +     LL ++  G+   +
Sbjct: 1738 D-WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1796

Query: 1698 VNNLLKKHQLLEAD----ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
              NL +++Q ++A     IS H+  +    S    L     + + + K+K    N +  K
Sbjct: 1797 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK-NMKELK 1855

Query: 1754 IKSMAA----SRRAKLNES--HRLHQFFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQN 1806
            +    A     ++ KL  S    L +F  D  + E W+++ +  + + + G  D+ G+  
Sbjct: 1856 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 1915

Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSD-------------DNTIGKEEIQQRLAQF 1853
              K+ K    ++ +H+  ++ +  +G ++ +             D +    E+Q++L   
Sbjct: 1916 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 1975

Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQF-------VANVEEEEAWINEKMTLVASEDYGD 1905
             + ++ L       G  L++ ++ YQ +       +A ++  EA  ++ +    SE    
Sbjct: 1976 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL----SEPIAV 2031

Query: 1906 TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH---HEENISSKMKGLNGK 1962
                +Q  L++ +A +   +  +  V  +    + L+         + +I   +  + G+
Sbjct: 2032 DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR 2091

Query: 1963 VSDLEKAAAQRKAKLDEN-SAFLQFNWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLL 2020
              DL K+  +R  KL    +  L      D +  W+G  E+SLK       + +++Q ++
Sbjct: 2092 YEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDII 2151

Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
            +K    +  +   Q    ++I A+ +++         +  +   + MK  S   + ++ +
Sbjct: 2152 SKNIMLEQDIAGRQ----SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2207

Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
             K+ L      +   +LF   ++K   F      A  ++  P +     ++  L +    
Sbjct: 2208 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGK-----DVTELSQYMQE 2262

Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQK 2200
              S     +     L  L ++I S  + S+         LE+T  NL K  KE E  +++
Sbjct: 2263 STSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL-----VLEKT-NNLSKKFKEMEDTIKE 2316

Query: 2201 EQRRQEENDKLRQEFAQHANAFHQWIQET--RTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
            ++       +    F     +   WI+ET  +  ++  S   E+ G     LE TK+  +
Sbjct: 2317 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLEDTKKLQE 2373

Query: 2259 EIRAMRSQLKKIEDLGAAM 2277
            +      +++K+ + G ++
Sbjct: 2374 KWSLKTPEIQKVNNSGISL 2392



 Score =  102 bits (255), Expect = 4e-21
 Identities = 450/2452 (18%), Positives = 904/2452 (36%), Gaps = 352/2452 (14%)

Query: 30   KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ--IASDENYKDPTNLQGKLQKHQA 87
            K L+T R Q+        F  R   EL  W+ EK +  +A D + ++ TN+  K   H  
Sbjct: 726  KLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEEEVAYDWSERN-TNIARKKDYHAE 783

Query: 88   FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQ 147
               E+      I  + E    ++ E H A  TI      +  QW  +L+           
Sbjct: 784  LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ----------L 833

Query: 148  AQKLVQYLRECEDVMDWIND-KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
             Q + Q+++E     ++ ND KEA      L       + +Q+K+           +R +
Sbjct: 834  CQCVEQHIKENTAYFEFFNDAKEATDYLRNL------KDAIQRKYS---------CDRSS 878

Query: 207  EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK---LFGAAEVQRF--N 261
             +++    + +    +EEL++ K    N   +    + L+ +     L  +  ++     
Sbjct: 879  SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 938

Query: 262  RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL 321
            R ++ TI   K+ E ++A++        +                 E  V ++C      
Sbjct: 939  RQIEITI--YKDDECVLANNSHRAKWKVISP------------TGNEAMVPSVCFTVPPP 984

Query: 322  QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF-RDLTSWVTEM 380
             +     A +I+ + + ++T W        E H  +         + +  R   S V  +
Sbjct: 985  NKEAVDLANRIEQQYQNVLTLWH-------ESHINMKSVVSWHYLINEIDRIRASNVASI 1037

Query: 381  KALINADE---LASDVAGAEALLDRHQEHK----GEIDAHEDSFKSADESGQALLAAGHY 433
            K ++  +    L++  +  E  L+  QE +     +I   E       +  Q LL +   
Sbjct: 1038 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1097

Query: 434  ASDEVREKLTVLSEERAALLELWELRRQQYEQCM------DL-QLFYRDTEQVDNWMSKQ 486
               E       +SE R   L L     +   Q        DL +  +R TEQ      K+
Sbjct: 1098 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE---KLKK 1154

Query: 487  EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
            E   L +DLG        +  K E+F  S +A    +  L      ++QN +      +T
Sbjct: 1155 ELERLKDDLG-------TITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 1206

Query: 547  RRDAL----LSRRNALHERAM---------RRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
              D L    L  +N     A+            A +AD  +++       + +S V+EK 
Sbjct: 1207 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1266

Query: 594  K---TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKL-IDVNHYAKD-- 647
            +      DE  K  +      + ++  + +   ++ + D L +  Q + + +++  +D  
Sbjct: 1267 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1326

Query: 648  ------EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHL 701
                  +        +  W + +E T+ K I+  +    +     +   ++ + E+E   
Sbjct: 1327 GIGKSLKYYRDTYHPLDDWIQQVETTQRK-IQENQPENSKTLATQLNQQKMLVSEIEMKQ 1385

Query: 702  AS-DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQE 760
            +  D+  K         K + L      A  D      ++ R+ Q +    A+ I ++  
Sbjct: 1386 SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS----ADLIIQEFM 1441

Query: 761  ALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGV 819
             L  RY AL   M    +   DSL RL++  + +E+E     +KE +  +    K +  +
Sbjct: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-----KKEHVEKAKELQKWVSNI 1496

Query: 820  QNLLKKHQALQAEIAGHEP--RIKAVTQKGNAMVEEGHFAAEDVKAKL------------ 865
               LK      AE AG  P  + K  +++ +   E+   A + ++  L            
Sbjct: 1497 SKTLK-----DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1551

Query: 866  HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE-----KEPIVGSTDYGK 920
            +EL ++ + L+   +    +    LQ  Q   D    E  + E     KE + G  D   
Sbjct: 1552 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLT 1611

Query: 921  DEDSAEALLKKHEALM-----SDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLAL 975
              ++   L+   EA M      +L  Y S  + L++  Q   Q +A    E  K     L
Sbjct: 1612 QTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA----EVVKNTENFL 1665

Query: 976  YDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035
             +  EK  +E    K  I   LN       ++ +   Q        K+LD   + +   +
Sbjct: 1666 KENGEKLSQE---DKALIEQKLNEAKIKCEQLNLKAEQS------KKELDKVVTTA---I 1713

Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
             EE   +A  ++  +++T+I      +S   K  E         G K K ++E++   F 
Sbjct: 1714 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE-------RAGTKHKQVIEQNGTHF- 1765

Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK-DINKVA 1154
                     Q  + K A    +EV  +L + +V   +    Q++L     ++K    K+ 
Sbjct: 1766 ---------QEGDGKSAIGEEDEVNGNLLETDV-DGQVGTTQENLNQQYQKVKAQHEKII 1815

Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
               ++  +  +  Q + +++   + P ++   +                   ++KEL   
Sbjct: 1816 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ------------------KNMKELKVH 1857

Query: 1215 WRSLQQLAEERSQLLGS-AHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQ 1272
            + +    +E++ +L  S   E+++F  D  E + W+++  Q L N +    D+  +    
Sbjct: 1858 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1917

Query: 1273 RKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE-------------DLQEKCTELNQ 1319
            ++ + F  D+ +    +  +  +  R++++    ++             ++Q K      
Sbjct: 1918 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1977

Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVS---SDELAKDVTGAE 1375
             + SL  + +     L D  D  +   D    L++ +       S   S+ +A D    +
Sbjct: 1978 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2037

Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLL-AHGHY--ASPEIKQKLDILDQERADLEK 1432
              LE  +  + +I ++    +  ++  + LL A G    A  +I++ LD +     DL K
Sbjct: 2038 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2097

Query: 1433 AWVQRRMMLDQCLELQLFHRD-CEQAENWMAAREAFLNTE-----DKGDSLDSVEALIKK 1486
            +  +R   L   L   L  +D  ++  +WM   E+ L  +     +     D +   I  
Sbjct: 2098 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2157

Query: 1487 HEDF---DKAINVQEEKIAALQAFADQLIAAGHYAK-GDISSRRNEVLDRWRRLKAQMIE 1542
             +D      +IN   EK+       D   A+   AK  D+S+R +E   + +   A+M E
Sbjct: 2158 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2217

Query: 1543 KRSKLGESQTLQQFSRDVDEIEAWISEKLQ--TASDESYKDPTNIQ--LSKLLSKHQKHQ 1598
             ++K      ++ F    ++++ ++  K Q  T  D   KD T +   + +  S+  +H+
Sbjct: 2218 LKTK------VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2271

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
                 LH+               I        +  V  +   L+ +++ +     EK + 
Sbjct: 2272 KHLEVLHSLLKE-----------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 2320

Query: 1659 LKEANKQQN-FNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLLKKHQLLEA 1710
            +    +Q + F   +K    W+ E       V+    +ED GK L     L +K  L   
Sbjct: 2321 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2380

Query: 1711 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTING--------RFQKIKSMAASRR 1762
            +I    +    L     S +T+ A   + VK     +NG         F   K + + ++
Sbjct: 2381 EIQKVNNSGISL-CNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2439

Query: 1763 AKLNESHRLHQFFRDMDDEESWIKEK--KLLVGSEDYGRDLTGVQNLRK----------- 1809
               + SH        + D+ + +  K  KL    E+    +  +Q + K           
Sbjct: 2440 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2499

Query: 1810 -----------KHKRLEAELAAHEPAIQGVLDTGKKLSDDN--TIGKEEIQQRLAQFVEH 1856
                       ++K  EAEL  +   +Q + D   +L ++N  T      +Q L +    
Sbjct: 2500 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2559

Query: 1857 WKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL- 1914
            W+EL QL   R Q+LEES     QF     + + W+ EK  +V+       L+    +L 
Sbjct: 2560 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS---VLGPLSIDPNMLN 2616

Query: 1915 ---KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE----------NISSKMKGLNG 1961
               ++ +    +F   K +   +   GQ ++ +                 ++ K   L G
Sbjct: 2617 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2676

Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
            ++SD      Q   K  +  + L               +  S K  D    LSS   + T
Sbjct: 2677 QLSDRCDWIDQAIVKSTQYQSLL---------------RSLSDKLSDLDNKLSSSLAVST 2721

Query: 2022 KQETFDAGLQAFQQEGIANITALKDQLLAAKHV---QSKAIEARH--ASLMKRWSQLLAN 2076
              +  +  L+  Q+     I   K Q+  A+ +    S  ++  +  A L ++   +L +
Sbjct: 2722 HPDAMNQQLETAQKMK-QEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2780

Query: 2077 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE--NAEEDLTDPVRCNSLEEIKAL 2134
                ++K      H +        F + +  F +W +    E++ + P+    L+ +++L
Sbjct: 2781 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA-KLDVLESL 2839

Query: 2135 REAHDAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
             + H  F  +L++    + + +AE +  +   + +        +  ++  W    K +KE
Sbjct: 2840 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2899

Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLD-GSCMVEESGTLESQLEA 2252
            RE +L       +E+ +   ++ +       WI + +  L +   C+    G  E+ +  
Sbjct: 2900 RENKL-------KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG--ENSIAK 2950

Query: 2253 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQ 2304
             K   +E+      ++ + +   ++     +D +        L Q+ D + +
Sbjct: 2951 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 3002



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 87/439 (19%), Positives = 179/439 (40%), Gaps = 52/439 (11%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIASDENY 72
            + +   ++ D++      S  R+ KLE++  F     DA + L  W+   + Q+A D+  
Sbjct: 4738 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4797

Query: 73   KDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
                +L    +  H+AF+ E+   + ++  L  +   +I      S  ++ ++ EL  +W
Sbjct: 4798 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4857

Query: 132  ELLLEKMREKGIKLLQAQKLVQYLRECED-------VMDWINDKEAIVTSEE-LGQDLEH 183
            E +        + + +  +L   LR+ E+       +++W+ + E  +     L  D + 
Sbjct: 4858 ETVC------ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4911

Query: 184  VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEE-ELIKTKQDEVNAAWQRLKG 242
            +  L  + +EF   +      +N+       ++   HP+    IK     + A ++ +  
Sbjct: 4912 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4971

Query: 243  LALQRQGKLFGAAEVQRFNRDVDETI-SWIKEKEQLMASDD---FGRDLASVQALLRKHE 298
             A Q Q +L  A       +++ E + +W++  E  +   D     +++  V+AL+ +H+
Sbjct: 4972 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5031

Query: 299  GLERDLAALE---DKV----KALCAEADRLQQSHPL--------------------SATQ 331
                ++   +   DKV    K   A+   LQ   P+                    S TQ
Sbjct: 5032 TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQ 5091

Query: 332  IQVKREE---LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
            I+ K      L++ W+Q+  LA ER  +LND+      L +F +    +   K +   + 
Sbjct: 5092 IETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNH 5151

Query: 389  LASDVAGAEALLDRHQEHK 407
              S V      +D+ Q+ K
Sbjct: 5152 KKSRVMDFFRRIDKDQDGK 5170



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 64/276 (23%), Positives = 114/276 (41%), Gaps = 12/276 (4%)

Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
           +DL +WV EM+  ++  E  SD+   E+ L+ H+     I+  E S K A  S   + A 
Sbjct: 649 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 708

Query: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
                    EKL  L  + A LL      R Q      L  F         W++++E   
Sbjct: 709 ---LKLTYAEKLHRLESQYAKLL---NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 762

Query: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
           +  D  +   ++      H +  + L  +EE I ++ E A +L+  NH A   +   R A
Sbjct: 763 VAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 822

Query: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK-DPSN--- 606
           + ++ + + +        + ++    +FF D+ E   ++   +K A    Y  D S+   
Sbjct: 823 MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL-RNLKDAIQRKYSCDRSSSIH 881

Query: 607 -LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDV 641
            L+  VQ+    + EL   +S I  L    + +I +
Sbjct: 882 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 917



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 22/279 (7%)

Query: 145 LLQAQKLVQYLRECE-------DVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTD 197
           LL++  L Q L E E       D+++W+++ +  +   E G DL  VE      E  +  
Sbjct: 628 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE---SHLENHKNV 684

Query: 198 MAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 257
             A EE  + + +     IQ   P +     K   + + + +L   +  ++  L     +
Sbjct: 685 HRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTL 741

Query: 258 QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAE 317
             F       + W+ EKE+   + D+     ++      H  L R+L   E+ +K++   
Sbjct: 742 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 801

Query: 318 ADR-LQQSHPLSATQIQVKREELITNWEQIRTL--AAERHARLNDSYRLQRFLADFRDLT 374
           A++ L ++HP   T I+  R  + T W  I  L    E+H + N +Y    F  D ++ T
Sbjct: 802 AEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQCVEQHIKENTAY--FEFFNDAKEAT 858

Query: 375 SWVTEMKALIN---ADELASDVAGAEALLDRHQEHKGEI 410
            ++  +K  I    + + +S +   E L+    E K E+
Sbjct: 859 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 897


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  278 bits (711), Expect = 5e-74
 Identities = 415/1966 (21%), Positives = 824/1966 (41%), Gaps = 178/1966 (9%)

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASET--IRTRLMELHRQ 130
            +D   LQ + +  +AF  +++A   +    ++T  +M++    + +   I+  L  L +Q
Sbjct: 3294 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 3353

Query: 131  WELLLEKM--REKGIK--LLQAQKLVQYLRECEDVMDWINDKEAI-----VTSEELGQDL 181
               LL++   RE+ ++  + + ++    L+E   ++    + E       + +E + Q L
Sbjct: 3354 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 3413

Query: 182  EHVEVLQKKFEEFQTDMAAHEERVNEVNQ----FAAKLIQEQHPEEELIKTKQDEVNAAW 237
               +V QK  EE +  +   ++ VN + Q     AAK    Q  E +L     D+VNA W
Sbjct: 3414 NMFKVFQK--EEIEP-LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL-----DDVNARW 3465

Query: 238  QRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLR 295
            + L     QR  +L  A     RF   ++  +SW+ + E+L+A+      +   V+A ++
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3525

Query: 296  KHEGLERDLAALEDKVKALCAEADRLQQS-HPLSATQIQVKREELITNWEQIRTLAAERH 354
            + + L+R L   +  V+ +  E +++  +  P    +I  +   L + WE +   A  R+
Sbjct: 3526 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3585

Query: 355  ARLND-SYRLQRFLADFRDLTSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDA 412
             +L   S   Q+F      L  W+T + K L+N + + +  +  E  + +H+  + +I  
Sbjct: 3586 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3645

Query: 413  HEDSFKSADESGQAL-LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-DLQ 470
            H      A   GQ+L + +     D V+ KL         + E    R +  +Q + + +
Sbjct: 3646 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3705

Query: 471  LFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLSAQEEKITAL 526
            +F  D  ++ NW+++    L    + D   S E L K+  +     E  L  ++    AL
Sbjct: 3706 IFGEDEVELMNWLNEVHDKLSKLSVQDY--STEGLWKQQSELRVLQEDILLRKQNVDQAL 3763

Query: 527  DEFATKLIQNNHYAMEDVATRRDALLSRRNALHE------RAMRRRAQLADSFHLQQFFR 580
                  L Q     +  +  + +A+ +R   + +      + + +  QLA   H      
Sbjct: 3764 LNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTH--- 3820

Query: 581  DSDELKSWVNE---KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
              +EL +W+++   ++ +   +  K     Q +++  +  + E   N++ +D+L +    
Sbjct: 3821 --EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNEVSSA 3877

Query: 638  LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN--QQQQFNRNVEDIELWLY 695
            L+++  +   E   +M    +   +L+  T  + ++  +A   + QQF++  +    W+ 
Sbjct: 3878 LLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT 3937

Query: 696  EVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA-GHFD 751
            E E  L S       +D T+ Q   +K   +E  +  H+D ID +     +   A    +
Sbjct: 3938 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHKIMTACSEEE 3995

Query: 752  AENIKKKQEALVARYEALKEPMVARKQKL--ADSLRLQQLFRDVEDEETWIREKEPIAAS 809
             +++KKK + ++  Y+ + +    R  +L  A SL + Q +   E+   W+ E + I + 
Sbjct: 3996 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETYEELWPWLTETQSIISQ 4054

Query: 810  TNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
                  +   ++   ++H+ L+  IA H+P I  + + G  ++E        ++ K    
Sbjct: 4055 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA 4114

Query: 869  NQKWEALKAKASQRRQDLEDSLQAQQYFADANEA--ESWMREKEPIVGSTDYGKDEDSAE 926
            +  +  +K    +R   L++++     F D  +   ES  R  E +        + +  +
Sbjct: 4115 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4174

Query: 927  ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ----EKS 982
              + +++ +  D+       + L+++ +    +   TD +   + V    D      E  
Sbjct: 4175 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4234

Query: 983  PREVTMKKGDILTLLNSTNKDWWK-----VEVNDRQGFVPAAYVKKLDPA----QSASRE 1033
               V  ++  +L ++    K W       V + D Q F+       +DP+    Q  + E
Sbjct: 4235 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4294

Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVS------LRMKQVEEL---YHSLLELGEKRK 1084
             + EE   +   QE++D    +  E  +        +  K ++EL   + SL +  + R 
Sbjct: 4295 TIREEIDGL---QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4351

Query: 1085 GMLEKSCKKFMLFREANE-LQQWINEKEAALTS-EEVGADLEQVEVLQKKFDDFQKDLKA 1142
              LE++ +  + +++  + +  W++     L S   +G DLE V+   ++   F+ +   
Sbjct: 4352 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4411

Query: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
             +  ++ +N  AE      L+ ++V              +E+D              HTV
Sbjct: 4412 QQIEMERLNHQAE------LLLKKVT-------------EESDK-------------HTV 4439

Query: 1203 ATFNSIKELNERWRSLQQ-LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN- 1260
               + + EL   W SL++ +   + +L G+   + +F    DE   W+      L+    
Sbjct: 4440 Q--DPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4497

Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTELNQ 1319
             G D  +++    KH   + D+ A    V ++ +    LI+S   E A +LQ K   LNQ
Sbjct: 4498 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4557

Query: 1320 AWSSLGKRADQRKAKL-GDSHDLQRFLSDFRDLMSWINGI-RGLVSSDELAKDVTGAEAL 1377
             W ++ ++ +QRK +L G     + F  +  DL  W+    R L++S  L      A+  
Sbjct: 4558 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4617

Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQ 1436
            L  H E     +A+  T+++  Q GQQ+LA     A   I Q ++ L ++   +E    +
Sbjct: 4618 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4677

Query: 1437 RRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAI 1494
            R+  L++ L L + FH   +   NW+   E  LN   +    LD+V   I +H+ F   +
Sbjct: 4678 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4737

Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRN---EVLDRWRRLKAQMIEKRSKLGESQ 1551
            N   E+I  L      L       K D+   +N    V  RW ++  +++E+   L +++
Sbjct: 4738 NSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4795

Query: 1552 T-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
               +QF     ++  W+  SEK   +  E   DP  I+    L++H++ Q      H+  
Sbjct: 4796 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ--LAQHKEFQKSLGAKHSVY 4853

Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK-QQN 1667
            D        G SL E+ + A     +   L+ L D+W  +  KS E+  KL+EA      
Sbjct: 4854 DTTNRT---GRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4910

Query: 1668 FNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
            F   ++    WL  VE  LA +   +G D+  V NL+  H+  + ++      ++ L   
Sbjct: 4911 FTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4969

Query: 1726 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR--------LHQFFRD 1777
            A  L+  S  D+S VK +   ++ R++ + +++ S++ +L  + R        +H     
Sbjct: 4970 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 5029

Query: 1778 MDDEESWIKEKKLLVGSEDYGRDLTGV-QNLRKKHKRLEAELAAHEPAIQGVL-----DT 1831
            + + E  ++   +L   ED  R L    +   KK +   AEL         VL     D+
Sbjct: 5030 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 5089

Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA---ARGQRLEESLEYQQFVANVEEEE 1888
               +    TI +   ++ LA   +H + L    A   A+ + LE  L + Q         
Sbjct: 5090 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQ--------- 5140

Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
             W    +T    E     +  ++ L+ +H+ F  + T  +  V+ V
Sbjct: 5141 -WAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5185



 Score =  265 bits (676), Expect = 5e-70
 Identities = 503/2529 (19%), Positives = 1024/2529 (40%), Gaps = 298/2529 (11%)

Query: 49   FQRDAEELEKWIQEKLQIASDENYKDPTN-----LQGKLQKHQAFEAEVQANSGAIVK-L 102
            FQ+ + + + W+  K +   ++N   P +     L+  ++ H+ F   + A S    K +
Sbjct: 2943 FQQMSRDFQAWLDTKKE---EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2999

Query: 103  DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA-QKLVQYLRECEDV 161
             E  NL++         ++ +L  +   W+   ++++E+  KL ++ +K ++Y  + E +
Sbjct: 3000 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 3059

Query: 162  MDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
              WI+  +  +   +   D    E    K +  Q +M  H   V  +N  A  L+     
Sbjct: 3060 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 3119

Query: 222  EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE-----KEQ 276
            ++E++    DE  +  Q++  +  Q   K F    + +  ++  E     K      KEQ
Sbjct: 3120 DKEVVT---DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQ 3176

Query: 277  LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
            L   D  G    S    L   +  ++ L AL+ +V      A RL Q   + A+  +   
Sbjct: 3177 LDIHDSLGSQAYS-NKYLTMLQTQQKSLQALKHQVDL----AKRLAQDLVVEASDSKGTS 3231

Query: 337  EELITNWEQIRTLAAERHARLNDSY---------RLQ---RFLADFRDLTSWVTEMKALI 384
            + L+    Q+ T+A E H+ L+            +LQ    F    R++ S   E    +
Sbjct: 3232 DVLL----QVETIAQE-HSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDEL 3286

Query: 385  NADELASDVAGAEALLDRHQEHKG---EIDAHEDSFKSADESGQALLAAGHYASDEV--R 439
              D +A     AE L  + +  K    +++A   S  +A+++ + +LA    + D V  +
Sbjct: 3287 --DSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3344

Query: 440  EKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDTEQVDNWMSKQEAFLLNED-LGD 497
              L  LS++   LL+  + R +Q E  +  L+ FY   ++    + K E    ++  +G 
Sbjct: 3345 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 3404

Query: 498  SLDSVEALLKKHEDFEKS----LSAQEEKITALDEFATKLIQNNHYAMEDVATRR----- 548
              +++   L   + F+K     L  +++ +  L +    LIQ+   A +  +T+      
Sbjct: 3405 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ---GLIQS---AAKSTSTQGLEHDL 3458

Query: 549  DALLSRRNALHERAMRRRAQLADSF-HLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN- 606
            D + +R   L+++  +R AQL ++  H  +F    + L SW+ +  +   ++  K PS  
Sbjct: 3459 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ--KPPSAE 3516

Query: 607  ---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA-KDEVAARMNEVISLWKK 662
               ++ ++Q+ +  +  L   +S ++ +++ G+K+      A K ++  +++ + S W+ 
Sbjct: 3517 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3576

Query: 663  LLEATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLAS-DDYGKDLTNVQNLQKKH 720
            LL   E +  +L   +   QQF+  +E +  WL  +E  L + +  G   + ++    +H
Sbjct: 3577 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3636

Query: 721  ALLEADVAAHQDRI-DGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
              LE D+  H   +   ++I       +   D + ++ K +     Y  ++E   +R + 
Sbjct: 3637 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3696

Query: 780  LADSLRLQQLFRDVEDE-ETWIRE-KEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHE 837
            L  +L   ++F + E E   W+ E  + ++  + +     G+     + + LQ +I   +
Sbjct: 3697 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3756

Query: 838  PRIKAVTQKGNAMVEEGHFAAEDV---KAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQ 893
              +      G  ++++     ++V   + KL  +  +++ +   ++   + LE +LQ A+
Sbjct: 3757 QNVDQALLNGLELLKQT--TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3814

Query: 894  QYFADANEAESWMR--EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
            +  +   E  +W+   E E +   T   K E++++A ++  E L  +     + + +L E
Sbjct: 3815 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNE 3873

Query: 952  QAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVND 1011
               S   ++ P     G E ++A              +  +   L++ T     KVE  D
Sbjct: 3874 -VSSALLELVPWRAREGLEKMVA--------------EDNERYRLVSDTITQ--KVEEID 3916

Query: 1012 RQGFVPAAYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITK------------ 1057
                    + +  D   S     E  L   G I L Q+Q   Q ++ K            
Sbjct: 3917 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3976

Query: 1058 ------------------EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
                              E  S+  ++ +V + Y ++ ++  +R   LE++      F E
Sbjct: 3977 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 4036

Query: 1100 A-NELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL 1157
               EL  W+ E ++ ++     A + E +   Q++    ++ +  ++  +  +NK    L
Sbjct: 4037 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 4096

Query: 1158 ----ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNE 1213
                  EG   +E + V    +Y  +  D              +    VA   +I +  +
Sbjct: 4097 LELSPGEGFSIQE-KYVAADTLYSQIKED--------------VKKRAVALDEAISQSTQ 4141

Query: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
                + Q+ E   +++    +      + ++ KE I E        N   D+  +Q L  
Sbjct: 4142 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK------NVSVDMEKLQPLYE 4195

Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
                    L   G+++ +     ++ I     SA+ +Q+K  ++   W ++    ++R+A
Sbjct: 4196 T-------LKQRGEEMIARSGGTDKDI-----SAKAVQDKLDQMVFIWENIHTLVEEREA 4243

Query: 1334 KLGDSHDL-QRFLSDFRDLMSWINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDAR 1391
            KL D  +L ++F  D   L+  I   +  +   ++   D +  +   E  +  R EID  
Sbjct: 4244 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 4303

Query: 1392 AGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
                      G +L+A  G    P +K+ +D L+     L KAW  R   L++ ++  + 
Sbjct: 4304 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 4363

Query: 1451 HRDCEQAE-NWM-AAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508
            ++D  QA  +W+  A     +    G  L++V+  I++ + F      Q+ ++  L   A
Sbjct: 4364 YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQA 4423

Query: 1509 DQLI--AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEA 1565
            + L+        K  +     E+   W  L+ ++I ++ KL G    L QF   +DE+ A
Sbjct: 4424 ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 4483

Query: 1566 WIS--EKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1623
            W++  E L +       DP  I++        KH   + ++ A+   +  V   GN LIE
Sbjct: 4484 WLTHTEGLLSEQKPVGGDPKAIEIELA-----KHHVLQNDVLAHQSTVEAVNKAGNDLIE 4538

Query: 1624 RGACAGSEDA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSE 1681
              + AG E + ++ +L  L  +WQ +++K+ ++ Q+L  A +Q + F+  I+D   WL++
Sbjct: 4539 --SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4596

Query: 1682 VEA-LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDT-SQ 1739
             E  LLAS+  G    +    L  H  + A   A E+  K L  +   ++        + 
Sbjct: 4597 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4656

Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLH-QFFRDMDDEESWIK--EKKLLVGSED 1796
            +    + +  +++ +++    R+ KL E+  L  +F   + D  +W+   E+ L V S  
Sbjct: 4657 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4716

Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE---IQQRLAQF 1853
                L  V     +HK    E+ +H   I  +  TG  L   +   K++   I+  L   
Sbjct: 4717 -SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISV 4773

Query: 1854 VEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQ 1911
               W+++ Q    RG+ L+++ +  +QF     +   W+ E    + SE +  +    I+
Sbjct: 4774 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4833

Query: 1912 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENIS--SKMKGLNGKVSDLEKA 1969
              L +H+ F+          +     G+ L +K +  ++N+     +  L  K   +   
Sbjct: 4834 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4893

Query: 1970 AAQRKAKLDENSAFL-QFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTKQETF 2026
            + +R+ KL+E   F  QF      +  W+   E  L  D   +G D+  V  L+   + F
Sbjct: 4894 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAF 4952

Query: 2027 DAGLQAFQQEGIANITALKD---QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKK 2083
               L     +  +++ ALK    +L+      S  ++ +   L  RW  + A S +++ +
Sbjct: 4953 QKELG----KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 5008

Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLT-DPVRCNSLEEIKALREAHDAFR 2142
            L   ++  R+ E+    F     A   W   AE+ L    V  +  + ++ L + H  F 
Sbjct: 5009 L---EAALRQAEE----FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 5061

Query: 2143 SSLSSAQADFNQLAELDRQIKSFRVASNPYT---WFTM------EALEETWRNLQK---- 2189
              L   +A+ N+   +   + +     +  T   W T+      E L    ++ Q+    
Sbjct: 5062 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 5121

Query: 2190 ----IIKERELELQKEQRRQEEN---DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEE 2242
                I K+  LE      +  E    DK ++   Q        I E +T++ +   M  +
Sbjct: 5122 LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEE---MTRK 5178

Query: 2243 SGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVG-------- 2294
               ++   +  KR+  +  +++S +  + D G A  +     + Y   S           
Sbjct: 5179 QPDVDKVTKTYKRRAADPSSLQSHIPVL-DKGRAGRKRFPASSLYPSGSQTQIETKNPRV 5237

Query: 2295 --LAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM---------------- 2336
              L  +W Q+  L +  +  L   +          E L+EF+                  
Sbjct: 5238 NLLVSKWQQVWLLALERRRKLNDALDRL-------EELREFANFDFDIWRKKYMRWMNHK 5290

Query: 2337 -------FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2389
                   F+  DKD+ G++  QEF   + S  +    +       E  A+ D  D + DG
Sbjct: 5291 KSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL-------EMSAVADIFDRDGDG 5343

Query: 2390 HVSLQEYMA 2398
            ++   E++A
Sbjct: 5344 YIDYYEFVA 5352



 Score =  233 bits (594), Expect = 2e-60
 Identities = 446/2453 (18%), Positives = 976/2453 (39%), Gaps = 266/2453 (10%)

Query: 21   QVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIAS--DENYKDPTN 77
            ++  ++    +L+  R+QKLE+S      FQ    +L++W+ EK  + S       DP  
Sbjct: 2693 EIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2752

Query: 78   LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTRLMELHRQWELL 134
            L  + Q+ Q    E         +L   G  ++S   E       ++ +L  + ++W+ L
Sbjct: 2753 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2812

Query: 135  LEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSEE-LGQDLEHVE 185
              ++ ++        +K  Q Q L++ L +   D+ + ++   A+ T  + + Q LE  +
Sbjct: 2813 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2872

Query: 186  VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNA---AWQRLKG 242
             ++++ ++ +  +   +    +++     L++E++ + EL +  +  + +     Q+ + 
Sbjct: 2873 KMKQEIQQEKKQIKVAQALCEDLSA----LVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2928

Query: 243  LALQRQGKLFGAAEVQRFNRDVDETISWIK-EKEQLMASDDFGRDLASVQALLRKHEGLE 301
                 Q     + + Q+ +RD     +W+  +KE+   S      L  +++L++ H+   
Sbjct: 2929 HVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2985

Query: 302  RDLAALEDKVKALCAEADRL---QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLN 358
            + L A     +   AE + L    Q    +A Q+Q+    + TNW+       ER  +L 
Sbjct: 2986 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT--IKTNWDTFNKQVKERENKLK 3043

Query: 359  DSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSF 417
            +S  +  ++      L  W+ + +  +   +   D A  E  + + +  + E+D H    
Sbjct: 3044 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 3103

Query: 418  KSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQ---CMD-LQLFY 473
            +  + +  +LL+      +       V+++E  +L++  ++  +Q      C++ +   +
Sbjct: 3104 ELLNNTANSLLSVCEIDKE-------VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 3156

Query: 474  RDTEQVDNWMSKQEAFLLNE-DLGDSLDSVEALLKKH----EDFEKSLSAQEEKITALDE 528
            ++ ++V     +Q      + D+ DSL S +A   K+    +  +KSL A + ++     
Sbjct: 3157 KEFQEVSKESKRQLQCAKEQLDIHDSLGS-QAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3215

Query: 529  FATKLI--QNNHYAMEDVATRRDALLSRRNALHERAMRR----RAQLADSFHLQQFFRDS 582
             A  L+   ++     DV  + + +    + L ++   +      +L    H Q   R+ 
Sbjct: 3216 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3275

Query: 583  DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVN 642
                +  ++++ +      +D   LQ + +  +AF  +L A  +  D   K  + ++   
Sbjct: 3276 FSQFAEFDDELDSMAPVG-RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATE 3334

Query: 643  HYAKDEVAARMN-EVISLW-KKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEG 699
              + D V  + + E +S    KLL+  + +  ++    ++ ++F   +++  + L + E 
Sbjct: 3335 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3394

Query: 700  HLASDD-YGKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQF--QDAGHFDAENI 755
            H  S    G +   + Q L       + ++   Q +   +    +      A     + +
Sbjct: 3395 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3454

Query: 756  KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-VEDEETWIREKEPIAASTNR-G 813
            +   + + AR++ L + +  R  +L ++L     F+D +E   +W+ + E + A+     
Sbjct: 3455 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS 3514

Query: 814  KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQK 871
             +   V+  +++ + LQ  +   +  ++ + ++G  +       A+ VK   +L  L+ +
Sbjct: 3515 AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSR 3573

Query: 872  WEALKAKASQRRQDLED-SLQAQQYFADANEAESWMREKEP-IVGSTDYGKDEDSAEALL 929
            WEAL  KA  R + LE  S+ AQQ+         W+   E  +V     G      E  +
Sbjct: 3574 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3633

Query: 930  KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMK 989
             +H+AL  D+  +   +     QA S  Q +        K++V +  D+ +    E+  K
Sbjct: 3634 AQHKALEDDIINHNKHLH----QAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3689

Query: 990  KGDILTLLNST-------NKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
                  LL           +D      W  EV+D+        + KL   Q  S E L +
Sbjct: 3690 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK--------LSKLS-VQDYSTEGLWK 3740

Query: 1038 EQGS-------IALRQEQID----NQTRITKEAGS-----VSLRMKQVEELYHSLLELGE 1081
            +Q         I LR++ +D    N   + K+        +  +++ ++  Y  + +L  
Sbjct: 3741 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3800

Query: 1082 KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV----GADLEQVEVLQKKFDDF 1136
                 LE++ +        +E L  W+++ E  L S E     G +  Q ++  K   + 
Sbjct: 3801 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK---EL 3857

Query: 1137 QKDLKANESRLKDINK--------------------VAEDLESEGLMAEEV-QAVQQQEV 1175
            +K+ K N++ L  +N+                    VAED E   L+++ + Q V++ + 
Sbjct: 3858 KKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDA 3917

Query: 1176 YGMMPRD-------------ETDSKTAS--------PWKSARLMV--------------- 1199
              +  +              ET+ K  S           SA+L V               
Sbjct: 3918 AILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3977

Query: 1200 -------HTVATFNSIKELNERWRSLQQL-----------AEERSQLLGSAHEVQRFHRD 1241
                   H + T  S +E     + L ++           +E   QL  +   V +F   
Sbjct: 3978 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 4037

Query: 1242 ADETKEWIEEKNQALNT-DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI 1300
             +E   W+ E    ++       +  +++  Q +H      +A     ++ + +T  +L+
Sbjct: 4038 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 4097

Query: 1301 QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRD--LMSWINGI 1358
            +  P     +QEK    +  +S + +   +R   L ++        D  D  L S    +
Sbjct: 4098 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 4157

Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
              L     ++ +V   +  +  ++    +++     ++  +Q G++++A       +I  
Sbjct: 4158 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4217

Query: 1419 KL--DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN-WMAAREAFLNTEDKGD 1475
            K   D LDQ    +   W     ++++  E +L     E AE  W       +  +D  D
Sbjct: 4218 KAVQDKLDQ----MVFIWENIHTLVEE-REAKLLDV-MELAEKFWCDHMSLIVTIKDTQD 4271

Query: 1476 SLDSVE------ALIKKHEDFDKAIN-----VQEEKIAALQAFADQLIAAGHYAKGDISS 1524
             +  +E      +++K+ ++  + I      +QEE    +   ++ + A G   K  +  
Sbjct: 4272 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4331

Query: 1525 RRNEVLDRWRRLKAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS---EKLQTASDESYK 1580
              +E+   W  L     ++  KL E+ Q   Q+   +  +  W+     KL + S     
Sbjct: 4332 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----- 4386

Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
             P    L  +  + ++ + F++E +     +  +      L+++      +  V+  L  
Sbjct: 4387 -PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 4445

Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQN-FNTGIKDFDFWLSEVEALLASED-YGKDLASV 1698
            L   W  L ++   +  KL+ A      F   + +   WL+  E LL+ +   G D  ++
Sbjct: 4446 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4505

Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGRFQKIKSM 1757
               L KH +L+ D+ AH+  ++ +N   + L+ SSA +  S +++K + +N R+Q +   
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4565

Query: 1758 AASRRAKLNESHRLHQFFR-DMDDEESWIK--EKKLLVGSEDYGRDLTGVQNLRKKHKRL 1814
               R+ +L+ + R  + F  +++D + W+   E+ LL      G   T  + L   H  +
Sbjct: 4566 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV-HMEV 4624

Query: 1815 EAELAAHEPAIQGVLDTGKK-LSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
             A   A E   + ++  G++ L+      +  I Q +    E W+ ++     R  +LEE
Sbjct: 4625 CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4684

Query: 1874 SLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931
            +L    +F  ++++   W+ + + TL  +      L  +   + +H+ F  +   H++++
Sbjct: 4685 ALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQI 4744

Query: 1932 NDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWK 1989
             ++   G  L   +   +   I + +  +  +   + +   +R   LD+      QF+  
Sbjct: 4745 IELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEA 4804

Query: 1990 ADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT-----A 2043
               +  W+ E E SL ++ +   D   ++T L + + F   L A  +  + + T     +
Sbjct: 4805 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA--KHSVYDTTNRTGRS 4862

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            LK++   A    +  ++   + L  +W  +   S  R+ KL EA     +  D       
Sbjct: 4863 LKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL----- 4915

Query: 2104 KASAFNSWFENAEEDLTD--PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
               A   W    E  L +  PV    ++ +  L + H AF+  L    +    L    R+
Sbjct: 4916 --QALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4972

Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANA 2221
            +       + +    M+ L   W  +  +   ++  L+   R+ EE       F    +A
Sbjct: 4973 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEE-------FHSVVHA 5025

Query: 2222 FHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
              +W+ E    L     + ++   L + ++  K   +++   R++L K   +G
Sbjct: 5026 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMG 5078



 Score =  226 bits (576), Expect = 2e-58
 Identities = 433/2280 (18%), Positives = 920/2280 (40%), Gaps = 246/2280 (10%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF-FQRDAEELEKWIQEKLQIASDENY- 72
            +Q +   +   +  F +    R  KL++S      ++   E L  WI +      +  + 
Sbjct: 3017 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 3076

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
             DP   +  + K ++ + E+  + G +  L+ T N ++S      E +      L ++ +
Sbjct: 3077 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 3136

Query: 133  LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND-----KEAIVTSEELGQDL---EHV 184
            ++ E++  K   L   + + Q  +E ++V           KE +   + LG      +++
Sbjct: 3137 MVTEQLHSKKFCL---ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3193

Query: 185  EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL------IKTKQDEVNAAWQ 238
             +LQ +    Q  + A + +V+   + A  L+ E    +        ++T   E +   Q
Sbjct: 3194 TMLQTQ----QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3249

Query: 239  RLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ------- 291
            ++       + KL G    Q   R++    +   ++   MA    GRD  ++Q       
Sbjct: 3250 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP--VGRDAETLQKQKETIK 3307

Query: 292  ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR--EELITNWEQIRTL 349
            A L+K E L     A  D     C      +++ P     + +KR  E L     ++   
Sbjct: 3308 AFLKKLEAL----MASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDR 3360

Query: 350  AAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEH-- 406
            A  R  ++  +  RL+ F +  ++ +  + + +      E +    G E      Q +  
Sbjct: 3361 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE----HEESQGPVGMETETINQQLNMF 3416

Query: 407  ----KGEIDAHEDSFKSADESGQALLAAGHYAS---------DEVREKLTVLSEERAALL 453
                K EI+  +   +  +  GQ L+ +   ++         D+V  +   L+++ A   
Sbjct: 3417 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA--- 3473

Query: 454  ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS-LDSVEALLKKHEDF 512
               +   Q  E  +    F    E + +WM   E  + N+    +    V+A +++ +  
Sbjct: 3474 ---QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL 3530

Query: 513  EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-SRRNALHERAMRRRAQLAD 571
            ++ L  ++  +  +     K+      A +    ++ +LL SR  AL  +A  R  QL  
Sbjct: 3531 QRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3590

Query: 572  -SFHLQQFFRDSDELKSWVN--EKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
             S   QQF    + L  W+   EK     +      S L+ ++ +H+A E ++  +   +
Sbjct: 3591 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3650

Query: 629  DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV- 687
                  GQ L  ++     ++     +   +W   +E  E K     E  QQ   N  + 
Sbjct: 3651 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW--YIEIQE-KSHSRSELLQQALCNAKIF 3707

Query: 688  --EDIEL--WLYEVEGHLAS---DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
              +++EL  WL EV   L+     DY  +   +   Q +  +L+ D+   +  +D   + 
Sbjct: 3708 GEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELRVLQEDILLRKQNVDQALLN 3765

Query: 741  ARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEE- 797
              +   Q  G  +   I+ K EA+ ARY+ + +      + L  +L+L +      +E  
Sbjct: 3766 GLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3824

Query: 798  TWIR--EKEPIAASTN--RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
            TW+   E E ++  T   +G++    Q   K+   L+ E   ++  + ++ +  +A++E 
Sbjct: 3825 TWLDKVEVELLSYETQVLKGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLEL 3881

Query: 854  GHFAA-EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE-SWMREKEP 911
              + A E ++  + E N+++  +    +Q+ ++++ ++   Q F  A +AE SW+ E E 
Sbjct: 3882 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3941

Query: 912  ---IVGSTDYGKDEDSAEALLKK--------HEALMSDLSAYGSSIQAL--REQAQSCRQ 958
                +G     +D+ SA+  ++K        H+ ++ DL   G  I      E+ QS ++
Sbjct: 3942 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 4001

Query: 959  QVAPTDDETGKELVLALYDY--QEKSPREVTMKKGDILTLLNSTNKDW--------WKVE 1008
            ++         + VL  YD   Q  S R + +++   L      N+ W        W  E
Sbjct: 4002 KL---------DKVLKNYDTICQINSERYLQLERAQSLV-----NQFWETYEELWPWLTE 4047

Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITK--------EAG 1060
                   +PA  ++     Q       L E   IA  +  ID   +           E  
Sbjct: 4048 TQSIISQLPAPALEYETLRQQQEEHRQLREL--IAEHKPHIDKMNKTGPQLLELSPGEGF 4105

Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVG 1120
            S+  +    + LY  + E  +KR   L+++  +   F +  ++ Q +       + E + 
Sbjct: 4106 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILE------SLERIV 4157

Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQ---QQEVYG 1177
              L Q   +  + +  ++ +  N++   D+ K+    E+     EE+ A      +++  
Sbjct: 4158 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4217

Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAE----ERSQLLGSAH 1233
               +D+ D      W++    +HT+     ++E   +   + +LAE    +   L+ +  
Sbjct: 4218 KAVQDKLDQMVFI-WEN----IHTL-----VEEREAKLLDVMELAEKFWCDHMSLIVTIK 4267

Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
            + Q F RD ++                 G D + V+  Q   E    ++  L ++++ + 
Sbjct: 4268 DTQDFIRDLEDP----------------GIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4311

Query: 1294 ETAERLIQSHPESAEDLQEKCT-ELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
                 LI +  E  + + +K   ELN AW SL K    R  KL ++     ++    + +
Sbjct: 4312 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4371

Query: 1352 MSWINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
              W++   G L S   +  D+   +  +E  ++ ++E   +    +      + LL    
Sbjct: 4372 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4431

Query: 1411 YASPE--IKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAF 1467
              S +  ++  L  L      LE+  + R+  L+  L  L  F    ++   W+   E  
Sbjct: 4432 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4491

Query: 1468 LNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
            L+ +   G    ++E  + KH      +   +  + A+    + LI +    +      +
Sbjct: 4492 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4551

Query: 1527 NEVLD-RWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEAWISE--------KLQTASD 1576
             EVL+ RW+ +  +  +++ +L G  +  + F  ++++++ W+++        K      
Sbjct: 4552 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4611

Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS-EDAVK 1635
            E+ K+  N+           H    A   A  +  + ++  G  ++ R  C  S E  + 
Sbjct: 4612 ETAKEQLNV-----------HMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNID 4658

Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALL-ASEDYGK 1693
              +  L ++W+ +  K  E+  KL+EA N    F+  ++DF  WL++ E  L  +     
Sbjct: 4659 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSL 4718

Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQ 1752
             L +V   + +H++   ++++H +++ +L+     L   S   D   +K+   ++  R++
Sbjct: 4719 ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWE 4778

Query: 1753 KIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTGVQNLRKK 1810
            K+      R   L+++  R  QF         W++E +  + SE +   D   ++    +
Sbjct: 4779 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4838

Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ--QRLAQFVEHWKELKQLAAARG 1868
            HK  +  L A          TG+ L +  ++  + ++    L++  + W  +   +  R 
Sbjct: 4839 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4898

Query: 1869 QRLEESLEYQ-QFVANVEEEEAWINEKMTLVASED--YGDTLAAIQGLLKKHEAFETDFT 1925
             +LEE+L +  QF   ++    W+      +A +   +GD +  +  L+  H+AF+ +  
Sbjct: 4899 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELG 4957

Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ 1985
                 V  +  + ++LI+ +      +  +M+ L+ +   +   +  ++ +L+  +A  Q
Sbjct: 4958 KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLE--AALRQ 5015

Query: 1986 FNWKADVVES---WIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
                  VV +   W+ E E +L+       D  +++TL+ + + F   L+  + E +   
Sbjct: 5016 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAE-LNKA 5074

Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMK-RWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
            T + D +LA  H  S        ++++ R+ ++LA +   +++L  A +     ++L   
Sbjct: 5075 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL-- 5132

Query: 2101 FAKKASAFNSWFENAEEDLTDP---VRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
                  A  +W + AE  LTD    V    +EE+KAL   H  F   ++  Q D +++ +
Sbjct: 5133 -----EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5187



 Score =  188 bits (477), Expect = 6e-47
 Identities = 502/2586 (19%), Positives = 1010/2586 (39%), Gaps = 326/2586 (12%)

Query: 14   DIQERRQ---QVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEEL-EKWIQEKLQIAS 68
            ++ E+RQ    + D   + K +S  + +   E    F + +  A++L E+W    +QI  
Sbjct: 1399 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI-- 1456

Query: 69   DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
            D   +D   L+G  +  + +          I +++ T   +       S+T+ T+L    
Sbjct: 1457 DNRLRD---LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---- 1509

Query: 129  RQWELLLEKMREKGIKLLQAQKLV-QYLRECEDVMDWINDKEAIVTSEELG-----QDLE 182
             Q ++L+ ++  K  K+ + QK   QY    +D         A+V S++       +   
Sbjct: 1510 NQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQS 1569

Query: 183  HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE-LIKTKQDEVNAAWQRLK 241
              +++ ++F + +T   A    + +  +FA   ++    EE+ L + K++ V  A +  K
Sbjct: 1570 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1629

Query: 242  GLA-LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH--- 297
             ++ + +  K    A    F++    +     +KEQL  +      L ++Q  L KH   
Sbjct: 1630 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEA------LQTIQLFLAKHGDK 1683

Query: 298  ------EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
                    LE+ +  L++    L +E+ +  Q    S T   VK EE I          A
Sbjct: 1684 MTDEERNELEKQVKTLQESYNLLFSESLKQLQE---SQTSGDVKVEEKIV---------A 1731

Query: 352  ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
            ER          Q +    + +   +T+ +  +   + A  +      L ++Q  + E+ 
Sbjct: 1732 ERQ---------QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1782

Query: 412  AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
                  K    S QAL        + ++E    LS+E  AL+E  +   +   +C  L L
Sbjct: 1783 ------KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKIKCEQLNL 1834

Query: 472  FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
                 EQ     SK+E           LD V     K E  + +   Q E+     E   
Sbjct: 1835 ---KAEQ-----SKKE-----------LDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1875

Query: 532  KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
              + N     E   T+   ++ + N  H +    ++ + +   +     ++D +   V  
Sbjct: 1876 DWLSNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGEEDEVNGNLLETD-VDGQVGT 1933

Query: 592  KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA 651
              +    +  K  +  +  + +HQA    + A QS    LEK GQ L   +   K+++  
Sbjct: 1934 TQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYL---SPEEKEKLQK 1987

Query: 652  RMNEVISLWKKLLEATELKGIKLREANQQQ--QFNRNVEDIELWLYEVEGHLASDDYGKD 709
             M E+   ++  L  +E K +KL  + Q++  +F+ +  + E WL + E  L + + G D
Sbjct: 1988 NMKELKVHYETALAESEKK-MKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 2046

Query: 710  -LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF---------QDAGHFDAE----NI 755
             +  +    K+      DV +H+  +  ITI   +          +D G  D       +
Sbjct: 2047 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 2106

Query: 756  KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED---------EETWIRE-KEP 805
            ++K +    R+ +L          L D +   Q + D            E T  +   EP
Sbjct: 2107 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2166

Query: 806  IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGHF--AAEDVK 862
            IA       D   +Q  L++ +ALQ +I+  +  ++ + +    +++  G    A  D++
Sbjct: 2167 IAV------DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2220

Query: 863  AKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA-NEAESWMREKEPIVGSTDYGKD 921
              L ++  ++E L    ++R + L+ +L       D  +E   WM   E  +        
Sbjct: 2221 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2280

Query: 922  EDSA-EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
              +A + ++ K+  L  D++   SSI A+ E+ +   +    TD  T   L   + D   
Sbjct: 2281 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET---TDPSTASSLQAKMKDLSA 2337

Query: 981  KSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG 1040
            +   E + K  + L  +        KVE+ +          +KL        + L E   
Sbjct: 2338 RFS-EASHKHKETLAKMEELKT---KVELFENLS-------EKLQTFLETKTQALTE--- 2383

Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE------LGEKRKGMLEKSCKKF 1094
             + +  + +   ++  +E+ S  L  K+  E+ HSLL+      L   +  +LEK+    
Sbjct: 2384 -VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNN-- 2440

Query: 1095 MLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK------ 1148
             L ++  E++  I EK+ A+TS +    L+  +VL K    + K+       ++      
Sbjct: 2441 -LSKKFKEMEDTIKEKKEAVTSCQ--EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2497

Query: 1149 DINKVAEDL----ESEGLMAEEVQAVQQQEVY--GMMPRDETDSKTASPWKSARLMVHTV 1202
            D+ K  ED     E   L   E+Q V    +    ++    T +K  +  KS   +++  
Sbjct: 2498 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2557

Query: 1203 ATFNSIKEL--NERWRSLQQ---------------LAEERSQLLGSAHEVQRFHRDADET 1245
             T  + +E   N+   S+++               L ++ ++L     ++Q+   ++   
Sbjct: 2558 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2617

Query: 1246 KEWIEEKNQALNTDNYGH---DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
             +W+++ N+            D  +V+    +++ FE +L    +KV  L +    L++ 
Sbjct: 2618 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2677

Query: 1303 HPESAEDLQEK--CTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIR 1359
            +P++ E  + K   TE++  W  L +    R+ KL +S ++L +F +    L  W+    
Sbjct: 2678 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2737

Query: 1360 GLVSS-DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
             +VS    L+ D        ++ Q    E   R   ++     GQ +L+      P ++ 
Sbjct: 2738 LMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG-EDPSLR- 2795

Query: 1419 KLDILDQERADLEKAWVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK--GD 1475
               I+ ++ A + + W      L D+C  +        Q ++ + +    L+  D     
Sbjct: 2796 --GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2853

Query: 1476 SL------DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAA--GHYAKGDISSRRN 1527
            SL      D++   ++  +   + I  ++++I   QA  + L A     Y K ++S +  
Sbjct: 2854 SLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLE 2913

Query: 1528 EVLDRWRRLKAQ----MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
             +L  ++ ++ +    +   +S    S   QQ SRD    +AW+  K +   +++   P 
Sbjct: 2914 GILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD---FQAWLDTKKE---EQNKSHPI 2967

Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA-VKARLAALA 1642
            + +L  L S  + H+ F   L A +      I  G +L+ +    GSE A ++ +L  + 
Sbjct: 2968 SAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEKAALQLQLNTIK 3025

Query: 1643 DQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
              W    ++  E+  KLKE+  K   +   ++    W+ + +  L    +  D A   N 
Sbjct: 3026 TNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENS 3085

Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
            + K + L+ ++  H   ++ LN+ A+SL++    D   V D+  ++  +   +     S+
Sbjct: 3086 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3145

Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG-RDLTGVQNLRKKHKRLEAELAA 1820
            +  L    +  + F+++  E     +++L    E     D  G Q    K+  +      
Sbjct: 3146 KFCLENMTQKFKEFQEVSKES----KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK 3201

Query: 1821 HEPAIQGVLDTGKKLSDDNTI------GKEEIQQRLAQFVEHWKELKQLAAARGQRLEES 1874
               A++  +D  K+L+ D  +      G  ++  ++    +    L Q    +   LE  
Sbjct: 3202 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3261

Query: 1875 LE----YQQFVANVEEEEAWINEKMTLVA-----SEDYGDTLAAIQGLLKKHEAFETDFT 1925
            L+    +Q  +  +  + A  ++++  +A     +E        I+  LKK EA      
Sbjct: 3262 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS-- 3319

Query: 1926 VHKDRVNDVCT-------NGQDLI----------KKNNHHEENISSKMKGLNGKVSDLEK 1968
               D  N  C           DL+          K+ N   +   ++ + + G +  LE+
Sbjct: 3320 --NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE 3377

Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
              +    KL E S  LQ   KA+  E   G     ++T+   + L+  + +  K+E    
Sbjct: 3378 FYS----KLKEFSILLQ---KAEEHEESQGPV--GMETETINQQLNMFK-VFQKEEI--E 3425

Query: 2029 GLQAFQQEGIANITALKDQLL--AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE 2086
             LQ  QQ+    +  L   L+  AAK   ++ +E     +  RW  L    A R  +L E
Sbjct: 3426 PLQGKQQD----VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3481

Query: 2087 AQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP--------VRCNSLEEIKALREAH 2138
            A  H  + +D          +  SW  + EE + +         V    ++E K L+   
Sbjct: 3482 ALLHCGRFQDAL-------ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLL 3534

Query: 2139 DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELEL 2198
            D  +S++   + +  ++A         ++         +  L+  W  L    + R  +L
Sbjct: 3535 DDRKSTVEVIKREGEKIATTAEPADKVKILKQ------LSLLDSRWEALLNKAETRNRQL 3588

Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
                   E    + Q+F +     ++W+      L++   +  ++  LE Q+   K    
Sbjct: 3589 -------EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3641

Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQW-DQLDQLGMRMQHNLEQQI 2317
            +I      L +   +G +++     ++K    S +  +Q W  ++ +        L+Q +
Sbjct: 3642 DIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQAL 3701

Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEF--------KSCLRSLGYDLPMVEE 2369
                  G  E  L    M + +   DK  +L+ Q++        +S LR L  D+ + ++
Sbjct: 3702 CNAKIFGEDEVEL----MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3757

Query: 2370 GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAF-RALSSEGKPY 2428
                     +        D  + +Q+ +  + +R  +  K S ++     +AL    + +
Sbjct: 3758 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3817

Query: 2429 VTKEEL 2434
             T EEL
Sbjct: 3818 STHEEL 3823



 Score =  167 bits (423), Expect = 1e-40
 Identities = 206/996 (20%), Positives = 441/996 (44%), Gaps = 77/996 (7%)

Query: 1    MDPSGVKVLETAE----DIQERRQQVLDRYHRFKELSTLRRQKLED--SYRFQFFQRDAE 54
            M+ +G ++LE +      IQE+       Y + KE    R   L++  S   QF  +  +
Sbjct: 4089 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4148

Query: 55   ELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD----------E 104
             LE    E++     E  + P ++  +++K    + ++  N    V ++          +
Sbjct: 4149 ILESL--ERIV----ERLRQPPSISAEVEK---IKEQISENKNVSVDMEKLQPLYETLKQ 4199

Query: 105  TGNLMISEG-----HFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ------ 153
             G  MI+         +++ ++ +L ++   WE +   + E+  KLL   +L +      
Sbjct: 4200 RGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4259

Query: 154  --YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
               +   +D  D+I D E      + G D   V+  Q+  E  + ++   +E ++ V   
Sbjct: 4260 MSLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4313

Query: 212  AAKLIQE-QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETIS 269
             ++LI     P++ ++K   DE+N+AW  L      R  KL  A +   ++   +     
Sbjct: 4314 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4373

Query: 270  WIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLS 328
            W+      +AS    G DL +V+  + + +  + +    + +++ L  +A+ L +     
Sbjct: 4374 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4433

Query: 329  ATQ--IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALIN 385
            + +  +Q    EL   W+ +      R  +L  +   L +F     +L +W+T  + L++
Sbjct: 4434 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4493

Query: 386  ADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASDEVREKL 442
              + +  D    E  L +H   + ++ AH+ + ++ +++G  L+  +AG  AS+ ++ KL
Sbjct: 4494 EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN-LQNKL 4552

Query: 443  TVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLL-NEDLGDSLD 500
             VL++    +LE  E R+QQ +  +   + F+ + E +  W++  E  LL ++ LG   +
Sbjct: 4553 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4612

Query: 501  SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAME-DVATRRDALLSRRNALH 559
            + +  L  H +   +  A+EE   +L +   +++     + E ++    + L  +  ++ 
Sbjct: 4613 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4672

Query: 560  ERAMRRRAQLADSFHLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQG----KVQKH 614
             +   R+ +L ++ +L   F +S  +  +W+ +  +T        PS +      ++ +H
Sbjct: 4673 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN--VASRPSLILDTVLFQIDEH 4730

Query: 615  QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISL---WKKLLEATELKG 671
            + F  E+++++ +I  L+K G  L   +   K +V    N +IS+   W+K+++    +G
Sbjct: 4731 KVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERG 4788

Query: 672  IKLREANQQ-QQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNLQKKHALLEADVAA 729
              L +A ++ +QF+     +  WL E E  L S+ +   D   ++    +H   +  + A
Sbjct: 4789 RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA 4848

Query: 730  HQDRIDGITIQARQFQDAGHFDAENIKKKQ--EALVARYEALKEPMVARKQKLADSLRLQ 787
                 D      R  ++      +N+K       L  +++ +    V R+ KL ++L   
Sbjct: 4849 KHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4908

Query: 788  QLFRD-VEDEETWIREKEP-IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
              F D ++    W+   EP +A       D+  V NL+  H+A Q E+      ++A+ +
Sbjct: 4909 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4968

Query: 846  KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAES 904
                ++E     +  VK ++ EL+ +WE + A +  ++  LE +L QA+++ +  +    
Sbjct: 4969 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 5028

Query: 905  WMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDL 939
            W+ E E  +        DED+   L+ +H+  M  L
Sbjct: 5029 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL 5064



 Score =  160 bits (405), Expect = 1e-38
 Identities = 484/2522 (19%), Positives = 976/2522 (38%), Gaps = 424/2522 (16%)

Query: 9    LETAEDIQERRQQVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA 67
            ++  E  Q + Q+  ++    K L+T L +QK+  S   +  Q   +E +K+ ++     
Sbjct: 1484 IQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVS-EIEMKQSKMDECQKYAEQYSATV 1540

Query: 68   SDENYKDPTN--LQGKLQKHQAFEAEVQANSGAIV--------KLDETGNLMISEGHFAS 117
             D   +  T   +    QK       +Q+++  I+        +      LM     FA 
Sbjct: 1541 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1600

Query: 118  ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLV----QYLRECEDV------MDWIND 167
            ++++     L  + + L E+ +E   K  + QK V    + L++ E           I+ 
Sbjct: 1601 DSLK----RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1656

Query: 168  KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE---------ERVNEVNQFAAKLIQE 218
            +E     E+L + L+ +++   K  +  TD   +E         E  N +   + K +QE
Sbjct: 1657 EEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1716

Query: 219  QHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
                     EE+++  +Q E     Q +  L  Q + +L G  E         E   +  
Sbjct: 1717 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1776

Query: 273  EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
            ++E+L   D  G   A  + +      L+ +   L  + KAL  +  +L ++  +   Q+
Sbjct: 1777 KQEELQ-KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ--KLNEAK-IKCEQL 1832

Query: 333  QVKREELITNWEQIRTLAA-ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELAS 391
             +K E+     +++ T A  E   ++    +L+       +L  W++      N D+  S
Sbjct: 1833 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DS 1885

Query: 392  DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
            + AG +        HK  I+ +   F+  D  G++ +       DEV   L + ++    
Sbjct: 1886 ERAGTK--------HKQVIEQNGTHFQEGD--GKSAIGE----EDEVNGNL-LETDVDGQ 1930

Query: 452  LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
            +    E   QQY++            Q +  +S+ +A ++      +  S + LL+K   
Sbjct: 1931 VGTTQENLNQQYQKVK---------AQHEKIISQHQAVII------ATQSAQVLLEKQGQ 1975

Query: 512  FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
            +   LS +E++         KL +N    M+++    +  L+      E+ M+    L +
Sbjct: 1976 Y---LSPEEKE---------KLQKN----MKELKVHYETALAES----EKKMKLTHSLQE 2015

Query: 572  SFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSN-LQGKVQKHQAFEAELSANQSRID 629
               L++F  D  E + W+ +  +   + EA  D  N L  K+++ ++F  ++ +++  + 
Sbjct: 2016 E--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 2073

Query: 630  ALEKAGQKLIDVNHYAKD-------------EVAARMNEVISLWKKLLEATELKGIKLRE 676
             +  +G ++++                    EV  +++     ++ L     + G  L++
Sbjct: 2074 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 2133

Query: 677  ANQQQQFNRNVE-----DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
               + Q   +        ++        HL S+    D  N+Q   ++   L+  +++ Q
Sbjct: 2134 LVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQ 2192

Query: 732  DRIDGITIQARQFQDA--GHFDAEN-IKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
              ++ +   A    DA      A+N I+K  + +V RYE L + +  R +KL  +L    
Sbjct: 2193 VAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2252

Query: 789  LFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
              +D  DE        E+ ++E+  +  ++        +Q+++ K+  L+ +IAG +  I
Sbjct: 2253 SVQDGLDEMLDWMGNVESSLKEQGQVPLNST------ALQDIISKNIMLEQDIAGRQSSI 2306

Query: 841  KAVTQKGNAMVEEGH-FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA 899
             A+ +K    +E      A  ++AK+ +L+ ++     K  +    +E+     + F + 
Sbjct: 2307 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 2366

Query: 900  NEA-ESWMREKEPIVGSTDY-GKD---------EDSAEALL-KKH----EALMSDLSAYG 943
            +E  ++++  K   +   D  GKD         E ++E L  KKH     +L+ ++S++G
Sbjct: 2367 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 2426

Query: 944  -----------------------SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
                                    +I+  +E   SC++Q+     +  + LV +L  + +
Sbjct: 2427 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL-----DAFQVLVKSLKSWIK 2481

Query: 981  KSPREVTMKKG-----DILTLLNSTNK--DWWKVEVNDRQ-----GFVPAAYVKKLD-PA 1027
            ++ ++V + +      D+   L  T K  + W ++  + Q     G      +  +  PA
Sbjct: 2482 ETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPA 2541

Query: 1028 QSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGML 1087
            ++ +    ++  G++   +    N        G  S++ K + ++ H   +LG   K  +
Sbjct: 2542 KAIAA---VKSGGAVLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI 2597

Query: 1088 EKSCKKFMLFREANE----LQQWINEKEAALTSEE---VGADLEQVEVLQKKFDDFQKDL 1140
             +   K    ++A E    + QW+ +     T  +      D E V+   ++   F+ +L
Sbjct: 2598 AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2657

Query: 1141 KANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
            K N ++++++ +K+ E LE                       +  D+  A  WK      
Sbjct: 2658 KQNVNKVQELKDKLTELLE-----------------------ENPDTPEAPRWKQM---- 2690

Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIEEKN----- 1253
                    + E++ +W+ L QL  +R Q L  S++ + +F     + K+W+ EK      
Sbjct: 2691 --------LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2742

Query: 1254 --------QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPE 1305
                      LNT      +   +   RK + +E+  AA    ++  GE         P 
Sbjct: 2743 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQ-YEQLTAAGQGILSRPGED--------PS 2793

Query: 1306 SAEDLQEKCTELNQAWSSL----GKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
                ++E+   + Q W SL      R D     +  S   Q  L    D +S ++    L
Sbjct: 2794 LRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KL 2851

Query: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQL--LAHGHYASPEIKQK 1419
             SS  ++         LE  Q+ + EI       +  +   + L  L    Y   E+ ++
Sbjct: 2852 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2911

Query: 1420 LDILDQERADLE-KAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK-GDSL 1477
            L+ + +   D+E KA    + +   C     F +     + W+  ++   N        L
Sbjct: 2912 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2971

Query: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA-KGDISSRRNEVLDRWRRL 1536
            D +E+LIK H+DF K +  Q        A  + L+     + K  +  + N +   W   
Sbjct: 2972 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 3031

Query: 1537 KAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS------EKLQTASDESYKDPTNIQLSK 1589
              Q+ E+ +KL ES +   ++   V+ +  WI       E+++   D +  + +  +L  
Sbjct: 3032 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 3091

Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLI--ERGACAGSEDAVKARLAALADQWQF 1647
            L  +  +H      L+  A+ +  V ++   ++  E  +     D V  +L +     + 
Sbjct: 3092 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 3151

Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQ 1706
            + QK  E  +  KE+ +Q        D       +   L S+ Y  K L  +    K  Q
Sbjct: 3152 MTQKFKEFQEVSKESKRQLQCAKEQLD-------IHDSLGSQAYSNKYLTMLQTQQKSLQ 3204

Query: 1707 LLEADISAHEDRLKDLNSQA-DSLMTSSA-FDTSQVKDKRDTINGRFQKIKSMAASRRAK 1764
             L+  +   +   +DL  +A DS  TS        +  +  T++   Q++    +    K
Sbjct: 3205 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS---QQVDEKCSFLETK 3261

Query: 1765 L-------NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ----NLRKKHKR 1813
            L       N    +   F + DDE         L      GRD   +Q     ++   K+
Sbjct: 3262 LQGIGHFQNTIREMFSQFAEFDDE---------LDSMAPVGRDAETLQKQKETIKAFLKK 3312

Query: 1814 LEAELAAHEPAIQGVLDTGKKL--SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1871
            LEA +A+++ A +    T K +  +++ +     I++ L    +   +L   A AR +++
Sbjct: 3313 LEALMASNDNANK----TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3368

Query: 1872 EESLE-YQQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQGLLKKHEAFE-TDFTVHK 1928
            E +++  ++F + ++E    + +      S+   G     I   L   + F+  +    +
Sbjct: 3369 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3428

Query: 1929 DRVNDVCTNGQDLIKK--NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
             +  DV   GQ LI+    +   + +   +  +N +   L K  AQR A+L E  A L  
Sbjct: 3429 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE--ALLHC 3486

Query: 1987 NWKADVVE---SWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT 2042
                D +E   SW+ + E  +        +   V+  + +Q+     LQ    +  + + 
Sbjct: 3487 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL----LQRLLDDRKSTVE 3542

Query: 2043 ALK---DQLLAAKHVQSKAIEARHASLM-KRWSQLLANSAARKKKL----LEAQSHFRKV 2094
             +K   +++        K    +  SL+  RW  LL  +  R ++L    + AQ     +
Sbjct: 3543 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3602

Query: 2095 EDL--FLTFAKKA---------------------SAFNSWFENAEEDLTDPVRCNSLEEI 2131
            E L  +LT  +K                       A      N  + L   V      ++
Sbjct: 3603 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3662

Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
             + RE  D  +S L     DF+Q+  ++ Q KS             E L++   N  KI 
Sbjct: 3663 LSSREDKDMVQSKL-----DFSQVWYIEIQEKSHS---------RSELLQQALCN-AKIF 3707

Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT------ 2245
             E E+EL       E +DKL +   Q  +    W Q++   +L    ++ +         
Sbjct: 3708 GEDEVELM--NWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3765

Query: 2246 ---------------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEH 2290
                           ++ +LEA K ++++I  + +      D+   +E+AL L  +   H
Sbjct: 3766 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST------DVAKTLEQALQLARRL--H 3817

Query: 2291 ST 2292
            ST
Sbjct: 3818 ST 3819



 Score =  112 bits (281), Expect = 3e-24
 Identities = 330/1819 (18%), Positives = 696/1819 (38%), Gaps = 265/1819 (14%)

Query: 669  LKGIKLREANQQQQFNRN-VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
            LK   L +   +++ N   V+D+  W+ E++  L   ++G DL +V++  + H  +   +
Sbjct: 767  LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 826

Query: 728  AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
               +  +    I   Q             +K   L ++Y  L      +++ L     L 
Sbjct: 827  EEFESSLKEAKISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQERHLDT---LH 880

Query: 788  QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
                   +E  W+ EKE    + +  +    +      H  L  E+   E  IK+V +  
Sbjct: 881  NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIA 940

Query: 848  NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
              ++ E H A   ++A    +  +W  +        Q ++++    ++F DA EA  ++R
Sbjct: 941  EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 1000

Query: 908  EKEPIVG---STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
              +  +    S D        E L+++      +L  Y S+I  L  +A++  Q      
Sbjct: 1001 NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 1060

Query: 965  DETGKEL--VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV 1021
            D   K    + A+ DY++    E+T+ K D   L N++++  WKV      +  VP+   
Sbjct: 1061 DCPLKTSIPIKAICDYRQ---IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCF 1117

Query: 1022 KKLDPAQSA-SRENLLEE--QGSIALRQEQIDNQTRIT------------KEAGSVSLRM 1066
                P + A    N +E+  Q  + L  E   N   +             + +   S++ 
Sbjct: 1118 TVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKT 1177

Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKK--------FMLFREANELQQWINEKEAALTSEE 1118
                E    L  L  + +  LE S +           L +E N  +Q+  E   +   EE
Sbjct: 1178 MLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREE 1237

Query: 1119 ------------------------------VGADLEQVEVLQKKFD-DFQKDLKANESRL 1147
                                          +   LE+ ++ +  F    Q+ LK    RL
Sbjct: 1238 QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL 1297

Query: 1148 KD----INKVAEDLESEGLMAEEVQAVQQQ---------EVYGM----MPRDETDSKTAS 1190
            KD    I    E+  S+   +  V  ++ +         +VY M    + + +T +    
Sbjct: 1298 KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 1357

Query: 1191 PWKSARLMVH-----------TVATFNSIKEL---NERWRS--------LQQLAEERSQL 1228
              ++A  +V             +A  N+I+ L    ++WRS           L +E  + 
Sbjct: 1358 NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 1417

Query: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
               + E+ + +++ D   +W +EK   L  + + +    +    R  EG  + L    D 
Sbjct: 1418 KAISDEMFKTYKERDLDFDWHKEKADQL-VERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1476

Query: 1289 VNSLG------ETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD- 1340
             + L       ET +R IQ + PE+++ L    T+LNQ    L    + +++K+ +    
Sbjct: 1477 YHPLDDWIQQVETTQRKIQENQPENSKTL---ATQLNQQ-KMLVSEIEMKQSKMDECQKY 1532

Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELA-----KDVTGAEALLERHQEHRTEIDARAGTF 1395
             +++ +  +D        R +V S + +     +  + A+ +++   + RT   A     
Sbjct: 1533 AEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1592

Query: 1396 QAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF----- 1450
              + +F          A   +K+    L++E   LE+   +++  +++  ELQ +     
Sbjct: 1593 TQYIKF----------AGDSLKR----LEEEEKSLEE---EKKEHVEKAKELQKWVSNIS 1635

Query: 1451 --HRDCEQA------ENWMAAREAFLNTEDKGDSLDSVEALIKKHED--FDKAINVQEEK 1500
               +D E+A      +  +++ E     E   ++L +++  + KH D   D+  N  E++
Sbjct: 1636 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1695

Query: 1501 IAALQAFADQLIAAG------HYAKGDISSRRNEVLDRWRRLKAQ-------MIEKRSKL 1547
            +  LQ   + L +            GD+      V +R +  K +       + +  ++L
Sbjct: 1696 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1755

Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASD---------ESYKDPTNI---------QLSK 1589
               Q          E++ + S++ +   D         E  K+  N          Q  K
Sbjct: 1756 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1815

Query: 1590 LLSKHQKHQAFE--AELHANADRIRGVIDMG-----NSLIERGACAGSEDAVKARLAALA 1642
             L + + ++A     +L+  A++ +  +D           E+ A     +  K ++  L 
Sbjct: 1816 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1875

Query: 1643 DQWQFLVQKSAEKS-QKLKEANKQQNFNTGIKDFDFWLSEVEA----LLASEDYGKDLAS 1697
            D W   V K +E++  K K+  +Q   +    D    + E +     LL ++  G+   +
Sbjct: 1876 D-WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1934

Query: 1698 VNNLLKKHQLLEAD----ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
              NL +++Q ++A     IS H+  +    S    L     + + + K+K    N +  K
Sbjct: 1935 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK-NMKELK 1993

Query: 1754 IKSMAA----SRRAKLNES--HRLHQFFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQN 1806
            +    A     ++ KL  S    L +F  D  + E W+++ +  + + + G  D+ G+  
Sbjct: 1994 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 2053

Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSD-------------DNTIGKEEIQQRLAQF 1853
              K+ K    ++ +H+  ++ +  +G ++ +             D +    E+Q++L   
Sbjct: 2054 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 2113

Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQF-------VANVEEEEAWINEKMTLVASEDYGD 1905
             + ++ L       G  L++ ++ YQ +       +A ++  EA  ++ +    SE    
Sbjct: 2114 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL----SEPIAV 2169

Query: 1906 TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH---HEENISSKMKGLNGK 1962
                +Q  L++ +A +   +  +  V  +    + L+         + +I   +  + G+
Sbjct: 2170 DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR 2229

Query: 1963 VSDLEKAAAQRKAKLDEN-SAFLQFNWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLL 2020
              DL K+  +R  KL    +  L      D +  W+G  E+SLK       + +++Q ++
Sbjct: 2230 YEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDII 2289

Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
            +K    +  +   Q    ++I A+ +++         +  +   + MK  S   + ++ +
Sbjct: 2290 SKNIMLEQDIAGRQ----SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2345

Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
             K+ L      +   +LF   ++K   F      A  ++  P +     ++  L +    
Sbjct: 2346 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGK-----DVTELSQYMQE 2400

Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQK 2200
              S     +     L  L ++I S  + S+         LE+T  NL K  KE E  +++
Sbjct: 2401 STSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL-----VLEKT-NNLSKKFKEMEDTIKE 2454

Query: 2201 EQRRQEENDKLRQEFAQHANAFHQWIQET--RTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
            ++       +    F     +   WI+ET  +  ++  S   E+ G     LE TK+  +
Sbjct: 2455 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLEDTKKLQE 2511

Query: 2259 EIRAMRSQLKKIEDLGAAM 2277
            +      +++K+ + G ++
Sbjct: 2512 KWSLKTPEIQKVNNSGISL 2530



 Score =  102 bits (255), Expect = 4e-21
 Identities = 450/2452 (18%), Positives = 904/2452 (36%), Gaps = 352/2452 (14%)

Query: 30   KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ--IASDENYKDPTNLQGKLQKHQA 87
            K L+T R Q+        F  R   EL  W+ EK +  +A D + ++ TN+  K   H  
Sbjct: 864  KLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEEEVAYDWSERN-TNIARKKDYHAE 921

Query: 88   FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQ 147
               E+      I  + E    ++ E H A  TI      +  QW  +L+           
Sbjct: 922  LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ----------L 971

Query: 148  AQKLVQYLRECEDVMDWIND-KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
             Q + Q+++E     ++ ND KEA      L       + +Q+K+           +R +
Sbjct: 972  CQCVEQHIKENTAYFEFFNDAKEATDYLRNL------KDAIQRKYS---------CDRSS 1016

Query: 207  EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK---LFGAAEVQRF--N 261
             +++    + +    +EEL++ K    N   +    + L+ +     L  +  ++     
Sbjct: 1017 SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 1076

Query: 262  RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL 321
            R ++ TI   K+ E ++A++        +                 E  V ++C      
Sbjct: 1077 RQIEITI--YKDDECVLANNSHRAKWKVISP------------TGNEAMVPSVCFTVPPP 1122

Query: 322  QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF-RDLTSWVTEM 380
             +     A +I+ + + ++T W        E H  +         + +  R   S V  +
Sbjct: 1123 NKEAVDLANRIEQQYQNVLTLWH-------ESHINMKSVVSWHYLINEIDRIRASNVASI 1175

Query: 381  KALINADE---LASDVAGAEALLDRHQEHK----GEIDAHEDSFKSADESGQALLAAGHY 433
            K ++  +    L++  +  E  L+  QE +     +I   E       +  Q LL +   
Sbjct: 1176 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1235

Query: 434  ASDEVREKLTVLSEERAALLELWELRRQQYEQCM------DL-QLFYRDTEQVDNWMSKQ 486
               E       +SE R   L L     +   Q        DL +  +R TEQ      K+
Sbjct: 1236 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE---KLKK 1292

Query: 487  EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
            E   L +DLG        +  K E+F  S +A    +  L      ++QN +      +T
Sbjct: 1293 ELERLKDDLG-------TITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 1344

Query: 547  RRDAL----LSRRNALHERAM---------RRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
              D L    L  +N     A+            A +AD  +++       + +S V+EK 
Sbjct: 1345 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1404

Query: 594  K---TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKL-IDVNHYAKD-- 647
            +      DE  K  +      + ++  + +   ++ + D L +  Q + + +++  +D  
Sbjct: 1405 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1464

Query: 648  ------EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHL 701
                  +        +  W + +E T+ K I+  +    +     +   ++ + E+E   
Sbjct: 1465 GIGKSLKYYRDTYHPLDDWIQQVETTQRK-IQENQPENSKTLATQLNQQKMLVSEIEMKQ 1523

Query: 702  AS-DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQE 760
            +  D+  K         K + L      A  D      ++ R+ Q +    A+ I ++  
Sbjct: 1524 SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS----ADLIIQEFM 1579

Query: 761  ALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGV 819
             L  RY AL   M    +   DSL RL++  + +E+E     +KE +  +    K +  +
Sbjct: 1580 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-----KKEHVEKAKELQKWVSNI 1634

Query: 820  QNLLKKHQALQAEIAGHEP--RIKAVTQKGNAMVEEGHFAAEDVKAKL------------ 865
               LK      AE AG  P  + K  +++ +   E+   A + ++  L            
Sbjct: 1635 SKTLK-----DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1689

Query: 866  HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE-----KEPIVGSTDYGK 920
            +EL ++ + L+   +    +    LQ  Q   D    E  + E     KE + G  D   
Sbjct: 1690 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLT 1749

Query: 921  DEDSAEALLKKHEALM-----SDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLAL 975
              ++   L+   EA M      +L  Y S  + L++  Q   Q +A    E  K     L
Sbjct: 1750 QTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA----EVVKNTENFL 1803

Query: 976  YDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035
             +  EK  +E    K  I   LN       ++ +   Q        K+LD   + +   +
Sbjct: 1804 KENGEKLSQE---DKALIEQKLNEAKIKCEQLNLKAEQS------KKELDKVVTTA---I 1851

Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
             EE   +A  ++  +++T+I      +S   K  E         G K K ++E++   F 
Sbjct: 1852 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE-------RAGTKHKQVIEQNGTHF- 1903

Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK-DINKVA 1154
                     Q  + K A    +EV  +L + +V   +    Q++L     ++K    K+ 
Sbjct: 1904 ---------QEGDGKSAIGEEDEVNGNLLETDV-DGQVGTTQENLNQQYQKVKAQHEKII 1953

Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
               ++  +  +  Q + +++   + P ++   +                   ++KEL   
Sbjct: 1954 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ------------------KNMKELKVH 1995

Query: 1215 WRSLQQLAEERSQLLGS-AHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQ 1272
            + +    +E++ +L  S   E+++F  D  E + W+++  Q L N +    D+  +    
Sbjct: 1996 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 2055

Query: 1273 RKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE-------------DLQEKCTELNQ 1319
            ++ + F  D+ +    +  +  +  R++++    ++             ++Q K      
Sbjct: 2056 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 2115

Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVS---SDELAKDVTGAE 1375
             + SL  + +     L D  D  +   D    L++ +       S   S+ +A D    +
Sbjct: 2116 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2175

Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLL-AHGHY--ASPEIKQKLDILDQERADLEK 1432
              LE  +  + +I ++    +  ++  + LL A G    A  +I++ LD +     DL K
Sbjct: 2176 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2235

Query: 1433 AWVQRRMMLDQCLELQLFHRD-CEQAENWMAAREAFLNTE-----DKGDSLDSVEALIKK 1486
            +  +R   L   L   L  +D  ++  +WM   E+ L  +     +     D +   I  
Sbjct: 2236 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2295

Query: 1487 HEDF---DKAINVQEEKIAALQAFADQLIAAGHYAK-GDISSRRNEVLDRWRRLKAQMIE 1542
             +D      +IN   EK+       D   A+   AK  D+S+R +E   + +   A+M E
Sbjct: 2296 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2355

Query: 1543 KRSKLGESQTLQQFSRDVDEIEAWISEKLQ--TASDESYKDPTNIQ--LSKLLSKHQKHQ 1598
             ++K      ++ F    ++++ ++  K Q  T  D   KD T +   + +  S+  +H+
Sbjct: 2356 LKTK------VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2409

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
                 LH+               I        +  V  +   L+ +++ +     EK + 
Sbjct: 2410 KHLEVLHSLLKE-----------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 2458

Query: 1659 LKEANKQQN-FNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLLKKHQLLEA 1710
            +    +Q + F   +K    W+ E       V+    +ED GK L     L +K  L   
Sbjct: 2459 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2518

Query: 1711 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTING--------RFQKIKSMAASRR 1762
            +I    +    L     S +T+ A   + VK     +NG         F   K + + ++
Sbjct: 2519 EIQKVNNSGISL-CNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2577

Query: 1763 AKLNESHRLHQFFRDMDDEESWIKEK--KLLVGSEDYGRDLTGVQNLRK----------- 1809
               + SH        + D+ + +  K  KL    E+    +  +Q + K           
Sbjct: 2578 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2637

Query: 1810 -----------KHKRLEAELAAHEPAIQGVLDTGKKLSDDN--TIGKEEIQQRLAQFVEH 1856
                       ++K  EAEL  +   +Q + D   +L ++N  T      +Q L +    
Sbjct: 2638 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2697

Query: 1857 WKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL- 1914
            W+EL QL   R Q+LEES     QF     + + W+ EK  +V+       L+    +L 
Sbjct: 2698 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS---VLGPLSIDPNMLN 2754

Query: 1915 ---KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE----------NISSKMKGLNG 1961
               ++ +    +F   K +   +   GQ ++ +                 ++ K   L G
Sbjct: 2755 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2814

Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
            ++SD      Q   K  +  + L               +  S K  D    LSS   + T
Sbjct: 2815 QLSDRCDWIDQAIVKSTQYQSLL---------------RSLSDKLSDLDNKLSSSLAVST 2859

Query: 2022 KQETFDAGLQAFQQEGIANITALKDQLLAAKHV---QSKAIEARH--ASLMKRWSQLLAN 2076
              +  +  L+  Q+     I   K Q+  A+ +    S  ++  +  A L ++   +L +
Sbjct: 2860 HPDAMNQQLETAQKMK-QEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2918

Query: 2077 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE--NAEEDLTDPVRCNSLEEIKAL 2134
                ++K      H +        F + +  F +W +    E++ + P+    L+ +++L
Sbjct: 2919 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA-KLDVLESL 2977

Query: 2135 REAHDAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
             + H  F  +L++    + + +AE +  +   + +        +  ++  W    K +KE
Sbjct: 2978 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 3037

Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLD-GSCMVEESGTLESQLEA 2252
            RE +L       +E+ +   ++ +       WI + +  L +   C+    G  E+ +  
Sbjct: 3038 RENKL-------KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG--ENSIAK 3088

Query: 2253 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQ 2304
             K   +E+      ++ + +   ++     +D +        L Q+ D + +
Sbjct: 3089 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 3140



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 87/439 (19%), Positives = 179/439 (40%), Gaps = 52/439 (11%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIASDENY 72
            + +   ++ D++      S  R+ KLE++  F     DA + L  W+   + Q+A D+  
Sbjct: 4876 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4935

Query: 73   KDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
                +L    +  H+AF+ E+   + ++  L  +   +I      S  ++ ++ EL  +W
Sbjct: 4936 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4995

Query: 132  ELLLEKMREKGIKLLQAQKLVQYLRECED-------VMDWINDKEAIVTSEE-LGQDLEH 183
            E +        + + +  +L   LR+ E+       +++W+ + E  +     L  D + 
Sbjct: 4996 ETVC------ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 5049

Query: 184  VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEE-ELIKTKQDEVNAAWQRLKG 242
            +  L  + +EF   +      +N+       ++   HP+    IK     + A ++ +  
Sbjct: 5050 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 5109

Query: 243  LALQRQGKLFGAAEVQRFNRDVDETI-SWIKEKEQLMASDD---FGRDLASVQALLRKHE 298
             A Q Q +L  A       +++ E + +W++  E  +   D     +++  V+AL+ +H+
Sbjct: 5110 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 5169

Query: 299  GLERDLAALE---DKV----KALCAEADRLQQSHPL--------------------SATQ 331
                ++   +   DKV    K   A+   LQ   P+                    S TQ
Sbjct: 5170 TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQ 5229

Query: 332  IQVKREE---LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
            I+ K      L++ W+Q+  LA ER  +LND+      L +F +    +   K +   + 
Sbjct: 5230 IETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNH 5289

Query: 389  LASDVAGAEALLDRHQEHK 407
              S V      +D+ Q+ K
Sbjct: 5290 KKSRVMDFFRRIDKDQDGK 5308



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 64/276 (23%), Positives = 114/276 (41%), Gaps = 12/276 (4%)

Query: 371  RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
            +DL +WV EM+  ++  E  SD+   E+ L+ H+     I+  E S K A  S   + A 
Sbjct: 787  QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 846

Query: 431  GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
                     EKL  L  + A LL      R Q      L  F         W++++E   
Sbjct: 847  ---LKLTYAEKLHRLESQYAKLL---NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 900

Query: 491  LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
            +  D  +   ++      H +  + L  +EE I ++ E A +L+  NH A   +   R A
Sbjct: 901  VAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 960

Query: 551  LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK-DPSN--- 606
            + ++ + + +        + ++    +FF D+ E   ++   +K A    Y  D S+   
Sbjct: 961  MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL-RNLKDAIQRKYSCDRSSSIH 1019

Query: 607  -LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDV 641
             L+  VQ+    + EL   +S I  L    + +I +
Sbjct: 1020 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 1055



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 22/279 (7%)

Query: 145  LLQAQKLVQYLRECE-------DVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTD 197
            LL++  L Q L E E       D+++W+++ +  +   E G DL  VE      E  +  
Sbjct: 766  LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE---SHLENHKNV 822

Query: 198  MAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 257
              A EE  + + +     IQ   P +     K   + + + +L   +  ++  L     +
Sbjct: 823  HRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTL 879

Query: 258  QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAE 317
              F       + W+ EKE+   + D+     ++      H  L R+L   E+ +K++   
Sbjct: 880  HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 939

Query: 318  ADR-LQQSHPLSATQIQVKREELITNWEQIRTL--AAERHARLNDSYRLQRFLADFRDLT 374
            A++ L ++HP   T I+  R  + T W  I  L    E+H + N +Y    F  D ++ T
Sbjct: 940  AEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQCVEQHIKENTAY--FEFFNDAKEAT 996

Query: 375  SWVTEMKALIN---ADELASDVAGAEALLDRHQEHKGEI 410
             ++  +K  I    + + +S +   E L+    E K E+
Sbjct: 997  DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 1035


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  278 bits (711), Expect = 5e-74
 Identities = 415/1966 (21%), Positives = 824/1966 (41%), Gaps = 178/1966 (9%)

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASET--IRTRLMELHRQ 130
            +D   LQ + +  +AF  +++A   +    ++T  +M++    + +   I+  L  L +Q
Sbjct: 3116 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 3175

Query: 131  WELLLEKM--REKGIK--LLQAQKLVQYLRECEDVMDWINDKEAI-----VTSEELGQDL 181
               LL++   RE+ ++  + + ++    L+E   ++    + E       + +E + Q L
Sbjct: 3176 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 3235

Query: 182  EHVEVLQKKFEEFQTDMAAHEERVNEVNQ----FAAKLIQEQHPEEELIKTKQDEVNAAW 237
               +V QK  EE +  +   ++ VN + Q     AAK    Q  E +L     D+VNA W
Sbjct: 3236 NMFKVFQK--EEIEP-LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL-----DDVNARW 3287

Query: 238  QRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLR 295
            + L     QR  +L  A     RF   ++  +SW+ + E+L+A+      +   V+A ++
Sbjct: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3347

Query: 296  KHEGLERDLAALEDKVKALCAEADRLQQS-HPLSATQIQVKREELITNWEQIRTLAAERH 354
            + + L+R L   +  V+ +  E +++  +  P    +I  +   L + WE +   A  R+
Sbjct: 3348 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3407

Query: 355  ARLND-SYRLQRFLADFRDLTSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDA 412
             +L   S   Q+F      L  W+T + K L+N + + +  +  E  + +H+  + +I  
Sbjct: 3408 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3467

Query: 413  HEDSFKSADESGQAL-LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-DLQ 470
            H      A   GQ+L + +     D V+ KL         + E    R +  +Q + + +
Sbjct: 3468 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3527

Query: 471  LFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLSAQEEKITAL 526
            +F  D  ++ NW+++    L    + D   S E L K+  +     E  L  ++    AL
Sbjct: 3528 IFGEDEVELMNWLNEVHDKLSKLSVQDY--STEGLWKQQSELRVLQEDILLRKQNVDQAL 3585

Query: 527  DEFATKLIQNNHYAMEDVATRRDALLSRRNALHE------RAMRRRAQLADSFHLQQFFR 580
                  L Q     +  +  + +A+ +R   + +      + + +  QLA   H      
Sbjct: 3586 LNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTH--- 3642

Query: 581  DSDELKSWVNE---KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
              +EL +W+++   ++ +   +  K     Q +++  +  + E   N++ +D+L +    
Sbjct: 3643 --EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNEVSSA 3699

Query: 638  LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN--QQQQFNRNVEDIELWLY 695
            L+++  +   E   +M    +   +L+  T  + ++  +A   + QQF++  +    W+ 
Sbjct: 3700 LLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT 3759

Query: 696  EVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA-GHFD 751
            E E  L S       +D T+ Q   +K   +E  +  H+D ID +     +   A    +
Sbjct: 3760 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHKIMTACSEEE 3817

Query: 752  AENIKKKQEALVARYEALKEPMVARKQKL--ADSLRLQQLFRDVEDEETWIREKEPIAAS 809
             +++KKK + ++  Y+ + +    R  +L  A SL + Q +   E+   W+ E + I + 
Sbjct: 3818 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETYEELWPWLTETQSIISQ 3876

Query: 810  TNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
                  +   ++   ++H+ L+  IA H+P I  + + G  ++E        ++ K    
Sbjct: 3877 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA 3936

Query: 869  NQKWEALKAKASQRRQDLEDSLQAQQYFADANEA--ESWMREKEPIVGSTDYGKDEDSAE 926
            +  +  +K    +R   L++++     F D  +   ES  R  E +        + +  +
Sbjct: 3937 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 3996

Query: 927  ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ----EKS 982
              + +++ +  D+       + L+++ +    +   TD +   + V    D      E  
Sbjct: 3997 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4056

Query: 983  PREVTMKKGDILTLLNSTNKDWWK-----VEVNDRQGFVPAAYVKKLDPA----QSASRE 1033
               V  ++  +L ++    K W       V + D Q F+       +DP+    Q  + E
Sbjct: 4057 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116

Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVS------LRMKQVEEL---YHSLLELGEKRK 1084
             + EE   +   QE++D    +  E  +        +  K ++EL   + SL +  + R 
Sbjct: 4117 TIREEIDGL---QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4173

Query: 1085 GMLEKSCKKFMLFREANE-LQQWINEKEAALTS-EEVGADLEQVEVLQKKFDDFQKDLKA 1142
              LE++ +  + +++  + +  W++     L S   +G DLE V+   ++   F+ +   
Sbjct: 4174 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4233

Query: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
             +  ++ +N  AE      L+ ++V              +E+D              HTV
Sbjct: 4234 QQIEMERLNHQAE------LLLKKVT-------------EESDK-------------HTV 4261

Query: 1203 ATFNSIKELNERWRSLQQ-LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN- 1260
               + + EL   W SL++ +   + +L G+   + +F    DE   W+      L+    
Sbjct: 4262 Q--DPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4319

Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTELNQ 1319
             G D  +++    KH   + D+ A    V ++ +    LI+S   E A +LQ K   LNQ
Sbjct: 4320 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4379

Query: 1320 AWSSLGKRADQRKAKL-GDSHDLQRFLSDFRDLMSWINGI-RGLVSSDELAKDVTGAEAL 1377
             W ++ ++ +QRK +L G     + F  +  DL  W+    R L++S  L      A+  
Sbjct: 4380 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4439

Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQ 1436
            L  H E     +A+  T+++  Q GQQ+LA     A   I Q ++ L ++   +E    +
Sbjct: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499

Query: 1437 RRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAI 1494
            R+  L++ L L + FH   +   NW+   E  LN   +    LD+V   I +H+ F   +
Sbjct: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559

Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRN---EVLDRWRRLKAQMIEKRSKLGESQ 1551
            N   E+I  L      L       K D+   +N    V  RW ++  +++E+   L +++
Sbjct: 4560 NSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4617

Query: 1552 T-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
               +QF     ++  W+  SEK   +  E   DP  I+    L++H++ Q      H+  
Sbjct: 4618 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ--LAQHKEFQKSLGAKHSVY 4675

Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK-QQN 1667
            D        G SL E+ + A     +   L+ L D+W  +  KS E+  KL+EA      
Sbjct: 4676 DTTNRT---GRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4732

Query: 1668 FNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
            F   ++    WL  VE  LA +   +G D+  V NL+  H+  + ++      ++ L   
Sbjct: 4733 FTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4791

Query: 1726 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR--------LHQFFRD 1777
            A  L+  S  D+S VK +   ++ R++ + +++ S++ +L  + R        +H     
Sbjct: 4792 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4851

Query: 1778 MDDEESWIKEKKLLVGSEDYGRDLTGV-QNLRKKHKRLEAELAAHEPAIQGVL-----DT 1831
            + + E  ++   +L   ED  R L    +   KK +   AEL         VL     D+
Sbjct: 4852 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 4911

Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA---ARGQRLEESLEYQQFVANVEEEE 1888
               +    TI +   ++ LA   +H + L    A   A+ + LE  L + Q         
Sbjct: 4912 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQ--------- 4962

Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
             W    +T    E     +  ++ L+ +H+ F  + T  +  V+ V
Sbjct: 4963 -WAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 5007



 Score =  265 bits (676), Expect = 5e-70
 Identities = 503/2529 (19%), Positives = 1024/2529 (40%), Gaps = 298/2529 (11%)

Query: 49   FQRDAEELEKWIQEKLQIASDENYKDPTN-----LQGKLQKHQAFEAEVQANSGAIVK-L 102
            FQ+ + + + W+  K +   ++N   P +     L+  ++ H+ F   + A S    K +
Sbjct: 2765 FQQMSRDFQAWLDTKKE---EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2821

Query: 103  DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA-QKLVQYLRECEDV 161
             E  NL++         ++ +L  +   W+   ++++E+  KL ++ +K ++Y  + E +
Sbjct: 2822 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2881

Query: 162  MDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
              WI+  +  +   +   D    E    K +  Q +M  H   V  +N  A  L+     
Sbjct: 2882 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2941

Query: 222  EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE-----KEQ 276
            ++E++    DE  +  Q++  +  Q   K F    + +  ++  E     K      KEQ
Sbjct: 2942 DKEVVT---DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQ 2998

Query: 277  LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
            L   D  G    S    L   +  ++ L AL+ +V      A RL Q   + A+  +   
Sbjct: 2999 LDIHDSLGSQAYS-NKYLTMLQTQQKSLQALKHQVDL----AKRLAQDLVVEASDSKGTS 3053

Query: 337  EELITNWEQIRTLAAERHARLNDSY---------RLQ---RFLADFRDLTSWVTEMKALI 384
            + L+    Q+ T+A E H+ L+            +LQ    F    R++ S   E    +
Sbjct: 3054 DVLL----QVETIAQE-HSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDEL 3108

Query: 385  NADELASDVAGAEALLDRHQEHKG---EIDAHEDSFKSADESGQALLAAGHYASDEV--R 439
              D +A     AE L  + +  K    +++A   S  +A+++ + +LA    + D V  +
Sbjct: 3109 --DSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3166

Query: 440  EKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDTEQVDNWMSKQEAFLLNED-LGD 497
              L  LS++   LL+  + R +Q E  +  L+ FY   ++    + K E    ++  +G 
Sbjct: 3167 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 3226

Query: 498  SLDSVEALLKKHEDFEKS----LSAQEEKITALDEFATKLIQNNHYAMEDVATRR----- 548
              +++   L   + F+K     L  +++ +  L +    LIQ+   A +  +T+      
Sbjct: 3227 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ---GLIQS---AAKSTSTQGLEHDL 3280

Query: 549  DALLSRRNALHERAMRRRAQLADSF-HLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN- 606
            D + +R   L+++  +R AQL ++  H  +F    + L SW+ +  +   ++  K PS  
Sbjct: 3281 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ--KPPSAE 3338

Query: 607  ---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA-KDEVAARMNEVISLWKK 662
               ++ ++Q+ +  +  L   +S ++ +++ G+K+      A K ++  +++ + S W+ 
Sbjct: 3339 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3398

Query: 663  LLEATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLAS-DDYGKDLTNVQNLQKKH 720
            LL   E +  +L   +   QQF+  +E +  WL  +E  L + +  G   + ++    +H
Sbjct: 3399 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3458

Query: 721  ALLEADVAAHQDRI-DGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
              LE D+  H   +   ++I       +   D + ++ K +     Y  ++E   +R + 
Sbjct: 3459 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3518

Query: 780  LADSLRLQQLFRDVEDE-ETWIRE-KEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHE 837
            L  +L   ++F + E E   W+ E  + ++  + +     G+     + + LQ +I   +
Sbjct: 3519 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3578

Query: 838  PRIKAVTQKGNAMVEEGHFAAEDV---KAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQ 893
              +      G  ++++     ++V   + KL  +  +++ +   ++   + LE +LQ A+
Sbjct: 3579 QNVDQALLNGLELLKQT--TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3636

Query: 894  QYFADANEAESWMR--EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
            +  +   E  +W+   E E +   T   K E++++A ++  E L  +     + + +L E
Sbjct: 3637 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNE 3695

Query: 952  QAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVND 1011
               S   ++ P     G E ++A              +  +   L++ T     KVE  D
Sbjct: 3696 -VSSALLELVPWRAREGLEKMVA--------------EDNERYRLVSDTITQ--KVEEID 3738

Query: 1012 RQGFVPAAYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITK------------ 1057
                    + +  D   S     E  L   G I L Q+Q   Q ++ K            
Sbjct: 3739 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3798

Query: 1058 ------------------EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
                              E  S+  ++ +V + Y ++ ++  +R   LE++      F E
Sbjct: 3799 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3858

Query: 1100 A-NELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL 1157
               EL  W+ E ++ ++     A + E +   Q++    ++ +  ++  +  +NK    L
Sbjct: 3859 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3918

Query: 1158 ----ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNE 1213
                  EG   +E + V    +Y  +  D              +    VA   +I +  +
Sbjct: 3919 LELSPGEGFSIQE-KYVAADTLYSQIKED--------------VKKRAVALDEAISQSTQ 3963

Query: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
                + Q+ E   +++    +      + ++ KE I E        N   D+  +Q L  
Sbjct: 3964 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK------NVSVDMEKLQPLYE 4017

Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
                    L   G+++ +     ++ I     SA+ +Q+K  ++   W ++    ++R+A
Sbjct: 4018 T-------LKQRGEEMIARSGGTDKDI-----SAKAVQDKLDQMVFIWENIHTLVEEREA 4065

Query: 1334 KLGDSHDL-QRFLSDFRDLMSWINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDAR 1391
            KL D  +L ++F  D   L+  I   +  +   ++   D +  +   E  +  R EID  
Sbjct: 4066 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 4125

Query: 1392 AGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
                      G +L+A  G    P +K+ +D L+     L KAW  R   L++ ++  + 
Sbjct: 4126 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 4185

Query: 1451 HRDCEQAE-NWM-AAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508
            ++D  QA  +W+  A     +    G  L++V+  I++ + F      Q+ ++  L   A
Sbjct: 4186 YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQA 4245

Query: 1509 DQLI--AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEA 1565
            + L+        K  +     E+   W  L+ ++I ++ KL G    L QF   +DE+ A
Sbjct: 4246 ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 4305

Query: 1566 WIS--EKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1623
            W++  E L +       DP  I++        KH   + ++ A+   +  V   GN LIE
Sbjct: 4306 WLTHTEGLLSEQKPVGGDPKAIEIELA-----KHHVLQNDVLAHQSTVEAVNKAGNDLIE 4360

Query: 1624 RGACAGSEDA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSE 1681
              + AG E + ++ +L  L  +WQ +++K+ ++ Q+L  A +Q + F+  I+D   WL++
Sbjct: 4361 --SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4418

Query: 1682 VEA-LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDT-SQ 1739
             E  LLAS+  G    +    L  H  + A   A E+  K L  +   ++        + 
Sbjct: 4419 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4478

Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLH-QFFRDMDDEESWIK--EKKLLVGSED 1796
            +    + +  +++ +++    R+ KL E+  L  +F   + D  +W+   E+ L V S  
Sbjct: 4479 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4538

Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE---IQQRLAQF 1853
                L  V     +HK    E+ +H   I  +  TG  L   +   K++   I+  L   
Sbjct: 4539 -SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISV 4595

Query: 1854 VEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQ 1911
               W+++ Q    RG+ L+++ +  +QF     +   W+ E    + SE +  +    I+
Sbjct: 4596 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4655

Query: 1912 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENIS--SKMKGLNGKVSDLEKA 1969
              L +H+ F+          +     G+ L +K +  ++N+     +  L  K   +   
Sbjct: 4656 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4715

Query: 1970 AAQRKAKLDENSAFL-QFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTKQETF 2026
            + +R+ KL+E   F  QF      +  W+   E  L  D   +G D+  V  L+   + F
Sbjct: 4716 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAF 4774

Query: 2027 DAGLQAFQQEGIANITALKD---QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKK 2083
               L     +  +++ ALK    +L+      S  ++ +   L  RW  + A S +++ +
Sbjct: 4775 QKELG----KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4830

Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLT-DPVRCNSLEEIKALREAHDAFR 2142
            L   ++  R+ E+    F     A   W   AE+ L    V  +  + ++ L + H  F 
Sbjct: 4831 L---EAALRQAEE----FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4883

Query: 2143 SSLSSAQADFNQLAELDRQIKSFRVASNPYT---WFTM------EALEETWRNLQK---- 2189
              L   +A+ N+   +   + +     +  T   W T+      E L    ++ Q+    
Sbjct: 4884 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4943

Query: 2190 ----IIKERELELQKEQRRQEEN---DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEE 2242
                I K+  LE      +  E    DK ++   Q        I E +T++ +   M  +
Sbjct: 4944 LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEE---MTRK 5000

Query: 2243 SGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVG-------- 2294
               ++   +  KR+  +  +++S +  + D G A  +     + Y   S           
Sbjct: 5001 QPDVDKVTKTYKRRAADPSSLQSHIPVL-DKGRAGRKRFPASSLYPSGSQTQIETKNPRV 5059

Query: 2295 --LAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM---------------- 2336
              L  +W Q+  L +  +  L   +          E L+EF+                  
Sbjct: 5060 NLLVSKWQQVWLLALERRRKLNDALDRL-------EELREFANFDFDIWRKKYMRWMNHK 5112

Query: 2337 -------FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2389
                   F+  DKD+ G++  QEF   + S  +    +       E  A+ D  D + DG
Sbjct: 5113 KSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL-------EMSAVADIFDRDGDG 5165

Query: 2390 HVSLQEYMA 2398
            ++   E++A
Sbjct: 5166 YIDYYEFVA 5174



 Score =  233 bits (594), Expect = 2e-60
 Identities = 446/2453 (18%), Positives = 976/2453 (39%), Gaps = 266/2453 (10%)

Query: 21   QVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIAS--DENYKDPTN 77
            ++  ++    +L+  R+QKLE+S      FQ    +L++W+ EK  + S       DP  
Sbjct: 2515 EIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2574

Query: 78   LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTRLMELHRQWELL 134
            L  + Q+ Q    E         +L   G  ++S   E       ++ +L  + ++W+ L
Sbjct: 2575 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2634

Query: 135  LEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSEE-LGQDLEHVE 185
              ++ ++        +K  Q Q L++ L +   D+ + ++   A+ T  + + Q LE  +
Sbjct: 2635 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2694

Query: 186  VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNA---AWQRLKG 242
             ++++ ++ +  +   +    +++     L++E++ + EL +  +  + +     Q+ + 
Sbjct: 2695 KMKQEIQQEKKQIKVAQALCEDLSA----LVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2750

Query: 243  LALQRQGKLFGAAEVQRFNRDVDETISWIK-EKEQLMASDDFGRDLASVQALLRKHEGLE 301
                 Q     + + Q+ +RD     +W+  +KE+   S      L  +++L++ H+   
Sbjct: 2751 HVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2807

Query: 302  RDLAALEDKVKALCAEADRL---QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLN 358
            + L A     +   AE + L    Q    +A Q+Q+    + TNW+       ER  +L 
Sbjct: 2808 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT--IKTNWDTFNKQVKERENKLK 2865

Query: 359  DSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSF 417
            +S  +  ++      L  W+ + +  +   +   D A  E  + + +  + E+D H    
Sbjct: 2866 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2925

Query: 418  KSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQ---CMD-LQLFY 473
            +  + +  +LL+      +       V+++E  +L++  ++  +Q      C++ +   +
Sbjct: 2926 ELLNNTANSLLSVCEIDKE-------VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 2978

Query: 474  RDTEQVDNWMSKQEAFLLNE-DLGDSLDSVEALLKKH----EDFEKSLSAQEEKITALDE 528
            ++ ++V     +Q      + D+ DSL S +A   K+    +  +KSL A + ++     
Sbjct: 2979 KEFQEVSKESKRQLQCAKEQLDIHDSLGS-QAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3037

Query: 529  FATKLI--QNNHYAMEDVATRRDALLSRRNALHERAMRR----RAQLADSFHLQQFFRDS 582
             A  L+   ++     DV  + + +    + L ++   +      +L    H Q   R+ 
Sbjct: 3038 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3097

Query: 583  DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVN 642
                +  ++++ +      +D   LQ + +  +AF  +L A  +  D   K  + ++   
Sbjct: 3098 FSQFAEFDDELDSMAPVG-RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATE 3156

Query: 643  HYAKDEVAARMN-EVISLW-KKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEG 699
              + D V  + + E +S    KLL+  + +  ++    ++ ++F   +++  + L + E 
Sbjct: 3157 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3216

Query: 700  HLASDD-YGKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQF--QDAGHFDAENI 755
            H  S    G +   + Q L       + ++   Q +   +    +      A     + +
Sbjct: 3217 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276

Query: 756  KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-VEDEETWIREKEPIAASTNR-G 813
            +   + + AR++ L + +  R  +L ++L     F+D +E   +W+ + E + A+     
Sbjct: 3277 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS 3336

Query: 814  KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQK 871
             +   V+  +++ + LQ  +   +  ++ + ++G  +       A+ VK   +L  L+ +
Sbjct: 3337 AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSR 3395

Query: 872  WEALKAKASQRRQDLED-SLQAQQYFADANEAESWMREKEP-IVGSTDYGKDEDSAEALL 929
            WEAL  KA  R + LE  S+ AQQ+         W+   E  +V     G      E  +
Sbjct: 3396 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3455

Query: 930  KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMK 989
             +H+AL  D+  +   +     QA S  Q +        K++V +  D+ +    E+  K
Sbjct: 3456 AQHKALEDDIINHNKHLH----QAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3511

Query: 990  KGDILTLLNST-------NKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
                  LL           +D      W  EV+D+        + KL   Q  S E L +
Sbjct: 3512 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK--------LSKLS-VQDYSTEGLWK 3562

Query: 1038 EQGS-------IALRQEQID----NQTRITKEAGS-----VSLRMKQVEELYHSLLELGE 1081
            +Q         I LR++ +D    N   + K+        +  +++ ++  Y  + +L  
Sbjct: 3563 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3622

Query: 1082 KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV----GADLEQVEVLQKKFDDF 1136
                 LE++ +        +E L  W+++ E  L S E     G +  Q ++  K   + 
Sbjct: 3623 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK---EL 3679

Query: 1137 QKDLKANESRLKDINK--------------------VAEDLESEGLMAEEV-QAVQQQEV 1175
            +K+ K N++ L  +N+                    VAED E   L+++ + Q V++ + 
Sbjct: 3680 KKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDA 3739

Query: 1176 YGMMPRD-------------ETDSKTAS--------PWKSARLMV--------------- 1199
              +  +              ET+ K  S           SA+L V               
Sbjct: 3740 AILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3799

Query: 1200 -------HTVATFNSIKELNERWRSLQQL-----------AEERSQLLGSAHEVQRFHRD 1241
                   H + T  S +E     + L ++           +E   QL  +   V +F   
Sbjct: 3800 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3859

Query: 1242 ADETKEWIEEKNQALNT-DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI 1300
             +E   W+ E    ++       +  +++  Q +H      +A     ++ + +T  +L+
Sbjct: 3860 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3919

Query: 1301 QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRD--LMSWINGI 1358
            +  P     +QEK    +  +S + +   +R   L ++        D  D  L S    +
Sbjct: 3920 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 3979

Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
              L     ++ +V   +  +  ++    +++     ++  +Q G++++A       +I  
Sbjct: 3980 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4039

Query: 1419 KL--DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN-WMAAREAFLNTEDKGD 1475
            K   D LDQ    +   W     ++++  E +L     E AE  W       +  +D  D
Sbjct: 4040 KAVQDKLDQ----MVFIWENIHTLVEE-REAKLLDV-MELAEKFWCDHMSLIVTIKDTQD 4093

Query: 1476 SLDSVE------ALIKKHEDFDKAIN-----VQEEKIAALQAFADQLIAAGHYAKGDISS 1524
             +  +E      +++K+ ++  + I      +QEE    +   ++ + A G   K  +  
Sbjct: 4094 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4153

Query: 1525 RRNEVLDRWRRLKAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS---EKLQTASDESYK 1580
              +E+   W  L     ++  KL E+ Q   Q+   +  +  W+     KL + S     
Sbjct: 4154 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----- 4208

Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
             P    L  +  + ++ + F++E +     +  +      L+++      +  V+  L  
Sbjct: 4209 -PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 4267

Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQN-FNTGIKDFDFWLSEVEALLASED-YGKDLASV 1698
            L   W  L ++   +  KL+ A      F   + +   WL+  E LL+ +   G D  ++
Sbjct: 4268 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327

Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGRFQKIKSM 1757
               L KH +L+ D+ AH+  ++ +N   + L+ SSA +  S +++K + +N R+Q +   
Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4387

Query: 1758 AASRRAKLNESHRLHQFFR-DMDDEESWIK--EKKLLVGSEDYGRDLTGVQNLRKKHKRL 1814
               R+ +L+ + R  + F  +++D + W+   E+ LL      G   T  + L   H  +
Sbjct: 4388 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV-HMEV 4446

Query: 1815 EAELAAHEPAIQGVLDTGKK-LSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
             A   A E   + ++  G++ L+      +  I Q +    E W+ ++     R  +LEE
Sbjct: 4447 CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4506

Query: 1874 SLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931
            +L    +F  ++++   W+ + + TL  +      L  +   + +H+ F  +   H++++
Sbjct: 4507 ALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQI 4566

Query: 1932 NDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWK 1989
             ++   G  L   +   +   I + +  +  +   + +   +R   LD+      QF+  
Sbjct: 4567 IELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEA 4626

Query: 1990 ADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT-----A 2043
               +  W+ E E SL ++ +   D   ++T L + + F   L A  +  + + T     +
Sbjct: 4627 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA--KHSVYDTTNRTGRS 4684

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            LK++   A    +  ++   + L  +W  +   S  R+ KL EA     +  D       
Sbjct: 4685 LKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL----- 4737

Query: 2104 KASAFNSWFENAEEDLTD--PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
               A   W    E  L +  PV    ++ +  L + H AF+  L    +    L    R+
Sbjct: 4738 --QALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794

Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANA 2221
            +       + +    M+ L   W  +  +   ++  L+   R+ EE       F    +A
Sbjct: 4795 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEE-------FHSVVHA 4847

Query: 2222 FHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
              +W+ E    L     + ++   L + ++  K   +++   R++L K   +G
Sbjct: 4848 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMG 4900



 Score =  226 bits (576), Expect = 2e-58
 Identities = 433/2280 (18%), Positives = 920/2280 (40%), Gaps = 246/2280 (10%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF-FQRDAEELEKWIQEKLQIASDENY- 72
            +Q +   +   +  F +    R  KL++S      ++   E L  WI +      +  + 
Sbjct: 2839 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2898

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
             DP   +  + K ++ + E+  + G +  L+ T N ++S      E +      L ++ +
Sbjct: 2899 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2958

Query: 133  LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND-----KEAIVTSEELGQDL---EHV 184
            ++ E++  K   L   + + Q  +E ++V           KE +   + LG      +++
Sbjct: 2959 MVTEQLHSKKFCL---ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3015

Query: 185  EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL------IKTKQDEVNAAWQ 238
             +LQ +    Q  + A + +V+   + A  L+ E    +        ++T   E +   Q
Sbjct: 3016 TMLQTQ----QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3071

Query: 239  RLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ------- 291
            ++       + KL G    Q   R++    +   ++   MA    GRD  ++Q       
Sbjct: 3072 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP--VGRDAETLQKQKETIK 3129

Query: 292  ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR--EELITNWEQIRTL 349
            A L+K E L     A  D     C      +++ P     + +KR  E L     ++   
Sbjct: 3130 AFLKKLEAL----MASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDR 3182

Query: 350  AAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEH-- 406
            A  R  ++  +  RL+ F +  ++ +  + + +      E +    G E      Q +  
Sbjct: 3183 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE----HEESQGPVGMETETINQQLNMF 3238

Query: 407  ----KGEIDAHEDSFKSADESGQALLAAGHYAS---------DEVREKLTVLSEERAALL 453
                K EI+  +   +  +  GQ L+ +   ++         D+V  +   L+++ A   
Sbjct: 3239 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA--- 3295

Query: 454  ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS-LDSVEALLKKHEDF 512
               +   Q  E  +    F    E + +WM   E  + N+    +    V+A +++ +  
Sbjct: 3296 ---QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL 3352

Query: 513  EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-SRRNALHERAMRRRAQLAD 571
            ++ L  ++  +  +     K+      A +    ++ +LL SR  AL  +A  R  QL  
Sbjct: 3353 QRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3412

Query: 572  -SFHLQQFFRDSDELKSWVN--EKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
             S   QQF    + L  W+   EK     +      S L+ ++ +H+A E ++  +   +
Sbjct: 3413 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3472

Query: 629  DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV- 687
                  GQ L  ++     ++     +   +W   +E  E K     E  QQ   N  + 
Sbjct: 3473 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW--YIEIQE-KSHSRSELLQQALCNAKIF 3529

Query: 688  --EDIEL--WLYEVEGHLAS---DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
              +++EL  WL EV   L+     DY  +   +   Q +  +L+ D+   +  +D   + 
Sbjct: 3530 GEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELRVLQEDILLRKQNVDQALLN 3587

Query: 741  ARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEE- 797
              +   Q  G  +   I+ K EA+ ARY+ + +      + L  +L+L +      +E  
Sbjct: 3588 GLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3646

Query: 798  TWIR--EKEPIAASTN--RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
            TW+   E E ++  T   +G++    Q   K+   L+ E   ++  + ++ +  +A++E 
Sbjct: 3647 TWLDKVEVELLSYETQVLKGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLEL 3703

Query: 854  GHFAA-EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE-SWMREKEP 911
              + A E ++  + E N+++  +    +Q+ ++++ ++   Q F  A +AE SW+ E E 
Sbjct: 3704 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3763

Query: 912  ---IVGSTDYGKDEDSAEALLKK--------HEALMSDLSAYGSSIQAL--REQAQSCRQ 958
                +G     +D+ SA+  ++K        H+ ++ DL   G  I      E+ QS ++
Sbjct: 3764 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3823

Query: 959  QVAPTDDETGKELVLALYDY--QEKSPREVTMKKGDILTLLNSTNKDW--------WKVE 1008
            ++         + VL  YD   Q  S R + +++   L      N+ W        W  E
Sbjct: 3824 KL---------DKVLKNYDTICQINSERYLQLERAQSLV-----NQFWETYEELWPWLTE 3869

Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITK--------EAG 1060
                   +PA  ++     Q       L E   IA  +  ID   +           E  
Sbjct: 3870 TQSIISQLPAPALEYETLRQQQEEHRQLREL--IAEHKPHIDKMNKTGPQLLELSPGEGF 3927

Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVG 1120
            S+  +    + LY  + E  +KR   L+++  +   F +  ++ Q +       + E + 
Sbjct: 3928 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILE------SLERIV 3979

Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQ---QQEVYG 1177
              L Q   +  + +  ++ +  N++   D+ K+    E+     EE+ A      +++  
Sbjct: 3980 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 4039

Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAE----ERSQLLGSAH 1233
               +D+ D      W++    +HT+     ++E   +   + +LAE    +   L+ +  
Sbjct: 4040 KAVQDKLDQMVFI-WEN----IHTL-----VEEREAKLLDVMELAEKFWCDHMSLIVTIK 4089

Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
            + Q F RD ++                 G D + V+  Q   E    ++  L ++++ + 
Sbjct: 4090 DTQDFIRDLEDP----------------GIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4133

Query: 1294 ETAERLIQSHPESAEDLQEKCT-ELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
                 LI +  E  + + +K   ELN AW SL K    R  KL ++     ++    + +
Sbjct: 4134 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4193

Query: 1352 MSWINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
              W++   G L S   +  D+   +  +E  ++ ++E   +    +      + LL    
Sbjct: 4194 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4253

Query: 1411 YASPE--IKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAF 1467
              S +  ++  L  L      LE+  + R+  L+  L  L  F    ++   W+   E  
Sbjct: 4254 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4313

Query: 1468 LNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
            L+ +   G    ++E  + KH      +   +  + A+    + LI +    +      +
Sbjct: 4314 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4373

Query: 1527 NEVLD-RWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEAWISE--------KLQTASD 1576
             EVL+ RW+ +  +  +++ +L G  +  + F  ++++++ W+++        K      
Sbjct: 4374 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4433

Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS-EDAVK 1635
            E+ K+  N+           H    A   A  +  + ++  G  ++ R  C  S E  + 
Sbjct: 4434 ETAKEQLNV-----------HMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNID 4480

Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALL-ASEDYGK 1693
              +  L ++W+ +  K  E+  KL+EA N    F+  ++DF  WL++ E  L  +     
Sbjct: 4481 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSL 4540

Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQ 1752
             L +V   + +H++   ++++H +++ +L+     L   S   D   +K+   ++  R++
Sbjct: 4541 ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWE 4600

Query: 1753 KIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTGVQNLRKK 1810
            K+      R   L+++  R  QF         W++E +  + SE +   D   ++    +
Sbjct: 4601 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4660

Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ--QRLAQFVEHWKELKQLAAARG 1868
            HK  +  L A          TG+ L +  ++  + ++    L++  + W  +   +  R 
Sbjct: 4661 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4720

Query: 1869 QRLEESLEYQ-QFVANVEEEEAWINEKMTLVASED--YGDTLAAIQGLLKKHEAFETDFT 1925
             +LEE+L +  QF   ++    W+      +A +   +GD +  +  L+  H+AF+ +  
Sbjct: 4721 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELG 4779

Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ 1985
                 V  +  + ++LI+ +      +  +M+ L+ +   +   +  ++ +L+  +A  Q
Sbjct: 4780 KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLE--AALRQ 4837

Query: 1986 FNWKADVVES---WIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
                  VV +   W+ E E +L+       D  +++TL+ + + F   L+  + E +   
Sbjct: 4838 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAE-LNKA 4896

Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMK-RWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
            T + D +LA  H  S        ++++ R+ ++LA +   +++L  A +     ++L   
Sbjct: 4897 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL-- 4954

Query: 2101 FAKKASAFNSWFENAEEDLTDP---VRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
                  A  +W + AE  LTD    V    +EE+KAL   H  F   ++  Q D +++ +
Sbjct: 4955 -----EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5009



 Score =  188 bits (477), Expect = 6e-47
 Identities = 502/2586 (19%), Positives = 1010/2586 (39%), Gaps = 326/2586 (12%)

Query: 14   DIQERRQ---QVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEEL-EKWIQEKLQIAS 68
            ++ E+RQ    + D   + K +S  + +   E    F + +  A++L E+W    +QI  
Sbjct: 1221 EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI-- 1278

Query: 69   DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
            D   +D   L+G  +  + +          I +++ T   +       S+T+ T+L    
Sbjct: 1279 DNRLRD---LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---- 1331

Query: 129  RQWELLLEKMREKGIKLLQAQKLV-QYLRECEDVMDWINDKEAIVTSEELG-----QDLE 182
             Q ++L+ ++  K  K+ + QK   QY    +D         A+V S++       +   
Sbjct: 1332 NQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQS 1391

Query: 183  HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE-LIKTKQDEVNAAWQRLK 241
              +++ ++F + +T   A    + +  +FA   ++    EE+ L + K++ V  A +  K
Sbjct: 1392 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1451

Query: 242  GLA-LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH--- 297
             ++ + +  K    A    F++    +     +KEQL  +      L ++Q  L KH   
Sbjct: 1452 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEA------LQTIQLFLAKHGDK 1505

Query: 298  ------EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
                    LE+ +  L++    L +E+ +  Q    S T   VK EE I          A
Sbjct: 1506 MTDEERNELEKQVKTLQESYNLLFSESLKQLQE---SQTSGDVKVEEKIV---------A 1553

Query: 352  ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
            ER          Q +    + +   +T+ +  +   + A  +      L ++Q  + E+ 
Sbjct: 1554 ERQ---------QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1604

Query: 412  AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
                  K    S QAL        + ++E    LS+E  AL+E  +   +   +C  L L
Sbjct: 1605 ------KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKIKCEQLNL 1656

Query: 472  FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
                 EQ     SK+E           LD V     K E  + +   Q E+     E   
Sbjct: 1657 ---KAEQ-----SKKE-----------LDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1697

Query: 532  KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
              + N     E   T+   ++ + N  H +    ++ + +   +     ++D +   V  
Sbjct: 1698 DWLSNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGEEDEVNGNLLETD-VDGQVGT 1755

Query: 592  KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA 651
              +    +  K  +  +  + +HQA    + A QS    LEK GQ L   +   K+++  
Sbjct: 1756 TQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYL---SPEEKEKLQK 1809

Query: 652  RMNEVISLWKKLLEATELKGIKLREANQQQ--QFNRNVEDIELWLYEVEGHLASDDYGKD 709
             M E+   ++  L  +E K +KL  + Q++  +F+ +  + E WL + E  L + + G D
Sbjct: 1810 NMKELKVHYETALAESEKK-MKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1868

Query: 710  -LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF---------QDAGHFDAE----NI 755
             +  +    K+      DV +H+  +  ITI   +          +D G  D       +
Sbjct: 1869 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1928

Query: 756  KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED---------EETWIRE-KEP 805
            ++K +    R+ +L          L D +   Q + D            E T  +   EP
Sbjct: 1929 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 1988

Query: 806  IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGHF--AAEDVK 862
            IA       D   +Q  L++ +ALQ +I+  +  ++ + +    +++  G    A  D++
Sbjct: 1989 IAV------DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 2042

Query: 863  AKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA-NEAESWMREKEPIVGSTDYGKD 921
              L ++  ++E L    ++R + L+ +L       D  +E   WM   E  +        
Sbjct: 2043 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 2102

Query: 922  EDSA-EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
              +A + ++ K+  L  D++   SSI A+ E+ +   +    TD  T   L   + D   
Sbjct: 2103 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET---TDPSTASSLQAKMKDLSA 2159

Query: 981  KSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG 1040
            +   E + K  + L  +        KVE+ +          +KL        + L E   
Sbjct: 2160 RFS-EASHKHKETLAKMEELKT---KVELFENLS-------EKLQTFLETKTQALTE--- 2205

Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE------LGEKRKGMLEKSCKKF 1094
             + +  + +   ++  +E+ S  L  K+  E+ HSLL+      L   +  +LEK+    
Sbjct: 2206 -VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNN-- 2262

Query: 1095 MLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK------ 1148
             L ++  E++  I EK+ A+TS +    L+  +VL K    + K+       ++      
Sbjct: 2263 -LSKKFKEMEDTIKEKKEAVTSCQ--EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2319

Query: 1149 DINKVAEDL----ESEGLMAEEVQAVQQQEVY--GMMPRDETDSKTASPWKSARLMVHTV 1202
            D+ K  ED     E   L   E+Q V    +    ++    T +K  +  KS   +++  
Sbjct: 2320 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2379

Query: 1203 ATFNSIKEL--NERWRSLQQ---------------LAEERSQLLGSAHEVQRFHRDADET 1245
             T  + +E   N+   S+++               L ++ ++L     ++Q+   ++   
Sbjct: 2380 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2439

Query: 1246 KEWIEEKNQALNTDNYGH---DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
             +W+++ N+            D  +V+    +++ FE +L    +KV  L +    L++ 
Sbjct: 2440 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2499

Query: 1303 HPESAEDLQEK--CTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIR 1359
            +P++ E  + K   TE++  W  L +    R+ KL +S ++L +F +    L  W+    
Sbjct: 2500 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2559

Query: 1360 GLVSS-DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
             +VS    L+ D        ++ Q    E   R   ++     GQ +L+      P ++ 
Sbjct: 2560 LMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG-EDPSLR- 2617

Query: 1419 KLDILDQERADLEKAWVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK--GD 1475
               I+ ++ A + + W      L D+C  +        Q ++ + +    L+  D     
Sbjct: 2618 --GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2675

Query: 1476 SL------DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAA--GHYAKGDISSRRN 1527
            SL      D++   ++  +   + I  ++++I   QA  + L A     Y K ++S +  
Sbjct: 2676 SLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLE 2735

Query: 1528 EVLDRWRRLKAQ----MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
             +L  ++ ++ +    +   +S    S   QQ SRD    +AW+  K +   +++   P 
Sbjct: 2736 GILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD---FQAWLDTKKE---EQNKSHPI 2789

Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA-VKARLAALA 1642
            + +L  L S  + H+ F   L A +      I  G +L+ +    GSE A ++ +L  + 
Sbjct: 2790 SAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEKAALQLQLNTIK 2847

Query: 1643 DQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
              W    ++  E+  KLKE+  K   +   ++    W+ + +  L    +  D A   N 
Sbjct: 2848 TNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENS 2907

Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
            + K + L+ ++  H   ++ LN+ A+SL++    D   V D+  ++  +   +     S+
Sbjct: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967

Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG-RDLTGVQNLRKKHKRLEAELAA 1820
            +  L    +  + F+++  E     +++L    E     D  G Q    K+  +      
Sbjct: 2968 KFCLENMTQKFKEFQEVSKES----KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK 3023

Query: 1821 HEPAIQGVLDTGKKLSDDNTI------GKEEIQQRLAQFVEHWKELKQLAAARGQRLEES 1874
               A++  +D  K+L+ D  +      G  ++  ++    +    L Q    +   LE  
Sbjct: 3024 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3083

Query: 1875 LE----YQQFVANVEEEEAWINEKMTLVA-----SEDYGDTLAAIQGLLKKHEAFETDFT 1925
            L+    +Q  +  +  + A  ++++  +A     +E        I+  LKK EA      
Sbjct: 3084 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS-- 3141

Query: 1926 VHKDRVNDVCT-------NGQDLI----------KKNNHHEENISSKMKGLNGKVSDLEK 1968
               D  N  C           DL+          K+ N   +   ++ + + G +  LE+
Sbjct: 3142 --NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE 3199

Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
              +    KL E S  LQ   KA+  E   G     ++T+   + L+  + +  K+E    
Sbjct: 3200 FYS----KLKEFSILLQ---KAEEHEESQGPV--GMETETINQQLNMFK-VFQKEEI--E 3247

Query: 2029 GLQAFQQEGIANITALKDQLL--AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE 2086
             LQ  QQ+    +  L   L+  AAK   ++ +E     +  RW  L    A R  +L E
Sbjct: 3248 PLQGKQQD----VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3303

Query: 2087 AQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP--------VRCNSLEEIKALREAH 2138
            A  H  + +D          +  SW  + EE + +         V    ++E K L+   
Sbjct: 3304 ALLHCGRFQDAL-------ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLL 3356

Query: 2139 DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELEL 2198
            D  +S++   + +  ++A         ++         +  L+  W  L    + R  +L
Sbjct: 3357 DDRKSTVEVIKREGEKIATTAEPADKVKILKQ------LSLLDSRWEALLNKAETRNRQL 3410

Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
                   E    + Q+F +     ++W+      L++   +  ++  LE Q+   K    
Sbjct: 3411 -------EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3463

Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQW-DQLDQLGMRMQHNLEQQI 2317
            +I      L +   +G +++     ++K    S +  +Q W  ++ +        L+Q +
Sbjct: 3464 DIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQAL 3523

Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEF--------KSCLRSLGYDLPMVEE 2369
                  G  E  L    M + +   DK  +L+ Q++        +S LR L  D+ + ++
Sbjct: 3524 CNAKIFGEDEVEL----MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3579

Query: 2370 GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAF-RALSSEGKPY 2428
                     +        D  + +Q+ +  + +R  +  K S ++     +AL    + +
Sbjct: 3580 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3639

Query: 2429 VTKEEL 2434
             T EEL
Sbjct: 3640 STHEEL 3645



 Score =  167 bits (423), Expect = 1e-40
 Identities = 206/996 (20%), Positives = 441/996 (44%), Gaps = 77/996 (7%)

Query: 1    MDPSGVKVLETAE----DIQERRQQVLDRYHRFKELSTLRRQKLED--SYRFQFFQRDAE 54
            M+ +G ++LE +      IQE+       Y + KE    R   L++  S   QF  +  +
Sbjct: 3911 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3970

Query: 55   ELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD----------E 104
             LE    E++     E  + P ++  +++K    + ++  N    V ++          +
Sbjct: 3971 ILESL--ERIV----ERLRQPPSISAEVEK---IKEQISENKNVSVDMEKLQPLYETLKQ 4021

Query: 105  TGNLMISEG-----HFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ------ 153
             G  MI+         +++ ++ +L ++   WE +   + E+  KLL   +L +      
Sbjct: 4022 RGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 4081

Query: 154  --YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
               +   +D  D+I D E      + G D   V+  Q+  E  + ++   +E ++ V   
Sbjct: 4082 MSLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4135

Query: 212  AAKLIQE-QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETIS 269
             ++LI     P++ ++K   DE+N+AW  L      R  KL  A +   ++   +     
Sbjct: 4136 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4195

Query: 270  WIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLS 328
            W+      +AS    G DL +V+  + + +  + +    + +++ L  +A+ L +     
Sbjct: 4196 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4255

Query: 329  ATQ--IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALIN 385
            + +  +Q    EL   W+ +      R  +L  +   L +F     +L +W+T  + L++
Sbjct: 4256 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4315

Query: 386  ADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASDEVREKL 442
              + +  D    E  L +H   + ++ AH+ + ++ +++G  L+  +AG  AS+ ++ KL
Sbjct: 4316 EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN-LQNKL 4374

Query: 443  TVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLL-NEDLGDSLD 500
             VL++    +LE  E R+QQ +  +   + F+ + E +  W++  E  LL ++ LG   +
Sbjct: 4375 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4434

Query: 501  SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAME-DVATRRDALLSRRNALH 559
            + +  L  H +   +  A+EE   +L +   +++     + E ++    + L  +  ++ 
Sbjct: 4435 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4494

Query: 560  ERAMRRRAQLADSFHLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQG----KVQKH 614
             +   R+ +L ++ +L   F +S  +  +W+ +  +T        PS +      ++ +H
Sbjct: 4495 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN--VASRPSLILDTVLFQIDEH 4552

Query: 615  QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISL---WKKLLEATELKG 671
            + F  E+++++ +I  L+K G  L   +   K +V    N +IS+   W+K+++    +G
Sbjct: 4553 KVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERG 4610

Query: 672  IKLREANQQ-QQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNLQKKHALLEADVAA 729
              L +A ++ +QF+     +  WL E E  L S+ +   D   ++    +H   +  + A
Sbjct: 4611 RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA 4670

Query: 730  HQDRIDGITIQARQFQDAGHFDAENIKKKQ--EALVARYEALKEPMVARKQKLADSLRLQ 787
                 D      R  ++      +N+K       L  +++ +    V R+ KL ++L   
Sbjct: 4671 KHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4730

Query: 788  QLFRD-VEDEETWIREKEP-IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
              F D ++    W+   EP +A       D+  V NL+  H+A Q E+      ++A+ +
Sbjct: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790

Query: 846  KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAES 904
                ++E     +  VK ++ EL+ +WE + A +  ++  LE +L QA+++ +  +    
Sbjct: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850

Query: 905  WMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDL 939
            W+ E E  +        DED+   L+ +H+  M  L
Sbjct: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL 4886



 Score =  160 bits (405), Expect = 1e-38
 Identities = 484/2522 (19%), Positives = 976/2522 (38%), Gaps = 424/2522 (16%)

Query: 9    LETAEDIQERRQQVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA 67
            ++  E  Q + Q+  ++    K L+T L +QK+  S   +  Q   +E +K+ ++     
Sbjct: 1306 IQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVS-EIEMKQSKMDECQKYAEQYSATV 1362

Query: 68   SDENYKDPTN--LQGKLQKHQAFEAEVQANSGAIV--------KLDETGNLMISEGHFAS 117
             D   +  T   +    QK       +Q+++  I+        +      LM     FA 
Sbjct: 1363 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1422

Query: 118  ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLV----QYLRECEDV------MDWIND 167
            ++++     L  + + L E+ +E   K  + QK V    + L++ E           I+ 
Sbjct: 1423 DSLK----RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1478

Query: 168  KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE---------ERVNEVNQFAAKLIQE 218
            +E     E+L + L+ +++   K  +  TD   +E         E  N +   + K +QE
Sbjct: 1479 EEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1538

Query: 219  QHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
                     EE+++  +Q E     Q +  L  Q + +L G  E         E   +  
Sbjct: 1539 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1598

Query: 273  EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
            ++E+L   D  G   A  + +      L+ +   L  + KAL  +  +L ++  +   Q+
Sbjct: 1599 KQEELQ-KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ--KLNEAK-IKCEQL 1654

Query: 333  QVKREELITNWEQIRTLAA-ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELAS 391
             +K E+     +++ T A  E   ++    +L+       +L  W++      N D+  S
Sbjct: 1655 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DS 1707

Query: 392  DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
            + AG +        HK  I+ +   F+  D  G++ +       DEV   L + ++    
Sbjct: 1708 ERAGTK--------HKQVIEQNGTHFQEGD--GKSAIGE----EDEVNGNL-LETDVDGQ 1752

Query: 452  LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
            +    E   QQY++            Q +  +S+ +A ++      +  S + LL+K   
Sbjct: 1753 VGTTQENLNQQYQKVK---------AQHEKIISQHQAVII------ATQSAQVLLEKQGQ 1797

Query: 512  FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
            +   LS +E++         KL +N    M+++    +  L+      E+ M+    L +
Sbjct: 1798 Y---LSPEEKE---------KLQKN----MKELKVHYETALAES----EKKMKLTHSLQE 1837

Query: 572  SFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSN-LQGKVQKHQAFEAELSANQSRID 629
               L++F  D  E + W+ +  +   + EA  D  N L  K+++ ++F  ++ +++  + 
Sbjct: 1838 E--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1895

Query: 630  ALEKAGQKLIDVNHYAKD-------------EVAARMNEVISLWKKLLEATELKGIKLRE 676
             +  +G ++++                    EV  +++     ++ L     + G  L++
Sbjct: 1896 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1955

Query: 677  ANQQQQFNRNVE-----DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
               + Q   +        ++        HL S+    D  N+Q   ++   L+  +++ Q
Sbjct: 1956 LVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQ 2014

Query: 732  DRIDGITIQARQFQDA--GHFDAEN-IKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
              ++ +   A    DA      A+N I+K  + +V RYE L + +  R +KL  +L    
Sbjct: 2015 VAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2074

Query: 789  LFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
              +D  DE        E+ ++E+  +  ++        +Q+++ K+  L+ +IAG +  I
Sbjct: 2075 SVQDGLDEMLDWMGNVESSLKEQGQVPLNST------ALQDIISKNIMLEQDIAGRQSSI 2128

Query: 841  KAVTQKGNAMVEEGH-FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA 899
             A+ +K    +E      A  ++AK+ +L+ ++     K  +    +E+     + F + 
Sbjct: 2129 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 2188

Query: 900  NEA-ESWMREKEPIVGSTDY-GKD---------EDSAEALL-KKH----EALMSDLSAYG 943
            +E  ++++  K   +   D  GKD         E ++E L  KKH     +L+ ++S++G
Sbjct: 2189 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 2248

Query: 944  -----------------------SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
                                    +I+  +E   SC++Q+     +  + LV +L  + +
Sbjct: 2249 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL-----DAFQVLVKSLKSWIK 2303

Query: 981  KSPREVTMKKG-----DILTLLNSTNK--DWWKVEVNDRQ-----GFVPAAYVKKLD-PA 1027
            ++ ++V + +      D+   L  T K  + W ++  + Q     G      +  +  PA
Sbjct: 2304 ETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPA 2363

Query: 1028 QSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGML 1087
            ++ +    ++  G++   +    N        G  S++ K + ++ H   +LG   K  +
Sbjct: 2364 KAIAA---VKSGGAVLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI 2419

Query: 1088 EKSCKKFMLFREANE----LQQWINEKEAALTSEE---VGADLEQVEVLQKKFDDFQKDL 1140
             +   K    ++A E    + QW+ +     T  +      D E V+   ++   F+ +L
Sbjct: 2420 AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2479

Query: 1141 KANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
            K N ++++++ +K+ E LE                       +  D+  A  WK      
Sbjct: 2480 KQNVNKVQELKDKLTELLE-----------------------ENPDTPEAPRWKQM---- 2512

Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIEEKN----- 1253
                    + E++ +W+ L QL  +R Q L  S++ + +F     + K+W+ EK      
Sbjct: 2513 --------LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2564

Query: 1254 --------QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPE 1305
                      LNT      +   +   RK + +E+  AA    ++  GE         P 
Sbjct: 2565 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQ-YEQLTAAGQGILSRPGED--------PS 2615

Query: 1306 SAEDLQEKCTELNQAWSSL----GKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
                ++E+   + Q W SL      R D     +  S   Q  L    D +S ++    L
Sbjct: 2616 LRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KL 2673

Query: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQL--LAHGHYASPEIKQK 1419
             SS  ++         LE  Q+ + EI       +  +   + L  L    Y   E+ ++
Sbjct: 2674 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2733

Query: 1420 LDILDQERADLE-KAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK-GDSL 1477
            L+ + +   D+E KA    + +   C     F +     + W+  ++   N        L
Sbjct: 2734 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2793

Query: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA-KGDISSRRNEVLDRWRRL 1536
            D +E+LIK H+DF K +  Q        A  + L+     + K  +  + N +   W   
Sbjct: 2794 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2853

Query: 1537 KAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS------EKLQTASDESYKDPTNIQLSK 1589
              Q+ E+ +KL ES +   ++   V+ +  WI       E+++   D +  + +  +L  
Sbjct: 2854 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2913

Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLI--ERGACAGSEDAVKARLAALADQWQF 1647
            L  +  +H      L+  A+ +  V ++   ++  E  +     D V  +L +     + 
Sbjct: 2914 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 2973

Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQ 1706
            + QK  E  +  KE+ +Q        D       +   L S+ Y  K L  +    K  Q
Sbjct: 2974 MTQKFKEFQEVSKESKRQLQCAKEQLD-------IHDSLGSQAYSNKYLTMLQTQQKSLQ 3026

Query: 1707 LLEADISAHEDRLKDLNSQA-DSLMTSSA-FDTSQVKDKRDTINGRFQKIKSMAASRRAK 1764
             L+  +   +   +DL  +A DS  TS        +  +  T++   Q++    +    K
Sbjct: 3027 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS---QQVDEKCSFLETK 3083

Query: 1765 L-------NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ----NLRKKHKR 1813
            L       N    +   F + DDE         L      GRD   +Q     ++   K+
Sbjct: 3084 LQGIGHFQNTIREMFSQFAEFDDE---------LDSMAPVGRDAETLQKQKETIKAFLKK 3134

Query: 1814 LEAELAAHEPAIQGVLDTGKKL--SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1871
            LEA +A+++ A +    T K +  +++ +     I++ L    +   +L   A AR +++
Sbjct: 3135 LEALMASNDNANK----TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3190

Query: 1872 EESLE-YQQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQGLLKKHEAFE-TDFTVHK 1928
            E +++  ++F + ++E    + +      S+   G     I   L   + F+  +    +
Sbjct: 3191 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 3250

Query: 1929 DRVNDVCTNGQDLIKK--NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
             +  DV   GQ LI+    +   + +   +  +N +   L K  AQR A+L E  A L  
Sbjct: 3251 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE--ALLHC 3308

Query: 1987 NWKADVVE---SWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT 2042
                D +E   SW+ + E  +        +   V+  + +Q+     LQ    +  + + 
Sbjct: 3309 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL----LQRLLDDRKSTVE 3364

Query: 2043 ALK---DQLLAAKHVQSKAIEARHASLM-KRWSQLLANSAARKKKL----LEAQSHFRKV 2094
             +K   +++        K    +  SL+  RW  LL  +  R ++L    + AQ     +
Sbjct: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3424

Query: 2095 EDL--FLTFAKKA---------------------SAFNSWFENAEEDLTDPVRCNSLEEI 2131
            E L  +LT  +K                       A      N  + L   V      ++
Sbjct: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3484

Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
             + RE  D  +S L     DF+Q+  ++ Q KS             E L++   N  KI 
Sbjct: 3485 LSSREDKDMVQSKL-----DFSQVWYIEIQEKSHS---------RSELLQQALCN-AKIF 3529

Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT------ 2245
             E E+EL       E +DKL +   Q  +    W Q++   +L    ++ +         
Sbjct: 3530 GEDEVELM--NWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3587

Query: 2246 ---------------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEH 2290
                           ++ +LEA K ++++I  + +      D+   +E+AL L  +   H
Sbjct: 3588 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST------DVAKTLEQALQLARRL--H 3639

Query: 2291 ST 2292
            ST
Sbjct: 3640 ST 3641



 Score =  112 bits (281), Expect = 3e-24
 Identities = 330/1819 (18%), Positives = 696/1819 (38%), Gaps = 265/1819 (14%)

Query: 669  LKGIKLREANQQQQFNRN-VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
            LK   L +   +++ N   V+D+  W+ E++  L   ++G DL +V++  + H  +   +
Sbjct: 589  LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 648

Query: 728  AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
               +  +    I   Q             +K   L ++Y  L      +++ L     L 
Sbjct: 649  EEFESSLKEAKISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQERHLDT---LH 702

Query: 788  QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
                   +E  W+ EKE    + +  +    +      H  L  E+   E  IK+V +  
Sbjct: 703  NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIA 762

Query: 848  NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
              ++ E H A   ++A    +  +W  +        Q ++++    ++F DA EA  ++R
Sbjct: 763  EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 822

Query: 908  EKEPIVG---STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
              +  +    S D        E L+++      +L  Y S+I  L  +A++  Q      
Sbjct: 823  NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 882

Query: 965  DETGKEL--VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV 1021
            D   K    + A+ DY++    E+T+ K D   L N++++  WKV      +  VP+   
Sbjct: 883  DCPLKTSIPIKAICDYRQ---IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCF 939

Query: 1022 KKLDPAQSA-SRENLLEE--QGSIALRQEQIDNQTRIT------------KEAGSVSLRM 1066
                P + A    N +E+  Q  + L  E   N   +             + +   S++ 
Sbjct: 940  TVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKT 999

Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKK--------FMLFREANELQQWINEKEAALTSEE 1118
                E    L  L  + +  LE S +           L +E N  +Q+  E   +   EE
Sbjct: 1000 MLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREE 1059

Query: 1119 ------------------------------VGADLEQVEVLQKKFD-DFQKDLKANESRL 1147
                                          +   LE+ ++ +  F    Q+ LK    RL
Sbjct: 1060 QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL 1119

Query: 1148 KD----INKVAEDLESEGLMAEEVQAVQQQ---------EVYGM----MPRDETDSKTAS 1190
            KD    I    E+  S+   +  V  ++ +         +VY M    + + +T +    
Sbjct: 1120 KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 1179

Query: 1191 PWKSARLMVH-----------TVATFNSIKEL---NERWRS--------LQQLAEERSQL 1228
              ++A  +V             +A  N+I+ L    ++WRS           L +E  + 
Sbjct: 1180 NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 1239

Query: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
               + E+ + +++ D   +W +EK   L  + + +    +    R  EG  + L    D 
Sbjct: 1240 KAISDEMFKTYKERDLDFDWHKEKADQL-VERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1298

Query: 1289 VNSLG------ETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD- 1340
             + L       ET +R IQ + PE+++ L    T+LNQ    L    + +++K+ +    
Sbjct: 1299 YHPLDDWIQQVETTQRKIQENQPENSKTL---ATQLNQQ-KMLVSEIEMKQSKMDECQKY 1354

Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELA-----KDVTGAEALLERHQEHRTEIDARAGTF 1395
             +++ +  +D        R +V S + +     +  + A+ +++   + RT   A     
Sbjct: 1355 AEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1414

Query: 1396 QAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF----- 1450
              + +F          A   +K+    L++E   LE+   +++  +++  ELQ +     
Sbjct: 1415 TQYIKF----------AGDSLKR----LEEEEKSLEE---EKKEHVEKAKELQKWVSNIS 1457

Query: 1451 --HRDCEQA------ENWMAAREAFLNTEDKGDSLDSVEALIKKHED--FDKAINVQEEK 1500
               +D E+A      +  +++ E     E   ++L +++  + KH D   D+  N  E++
Sbjct: 1458 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1517

Query: 1501 IAALQAFADQLIAAG------HYAKGDISSRRNEVLDRWRRLKAQ-------MIEKRSKL 1547
            +  LQ   + L +            GD+      V +R +  K +       + +  ++L
Sbjct: 1518 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1577

Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASD---------ESYKDPTNI---------QLSK 1589
               Q          E++ + S++ +   D         E  K+  N          Q  K
Sbjct: 1578 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1637

Query: 1590 LLSKHQKHQAFE--AELHANADRIRGVIDMG-----NSLIERGACAGSEDAVKARLAALA 1642
             L + + ++A     +L+  A++ +  +D           E+ A     +  K ++  L 
Sbjct: 1638 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1697

Query: 1643 DQWQFLVQKSAEKS-QKLKEANKQQNFNTGIKDFDFWLSEVEA----LLASEDYGKDLAS 1697
            D W   V K +E++  K K+  +Q   +    D    + E +     LL ++  G+   +
Sbjct: 1698 D-WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1756

Query: 1698 VNNLLKKHQLLEAD----ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
              NL +++Q ++A     IS H+  +    S    L     + + + K+K    N +  K
Sbjct: 1757 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK-NMKELK 1815

Query: 1754 IKSMAA----SRRAKLNES--HRLHQFFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQN 1806
            +    A     ++ KL  S    L +F  D  + E W+++ +  + + + G  D+ G+  
Sbjct: 1816 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 1875

Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSD-------------DNTIGKEEIQQRLAQF 1853
              K+ K    ++ +H+  ++ +  +G ++ +             D +    E+Q++L   
Sbjct: 1876 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 1935

Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQF-------VANVEEEEAWINEKMTLVASEDYGD 1905
             + ++ L       G  L++ ++ YQ +       +A ++  EA  ++ +    SE    
Sbjct: 1936 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL----SEPIAV 1991

Query: 1906 TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH---HEENISSKMKGLNGK 1962
                +Q  L++ +A +   +  +  V  +    + L+         + +I   +  + G+
Sbjct: 1992 DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR 2051

Query: 1963 VSDLEKAAAQRKAKLDEN-SAFLQFNWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLL 2020
              DL K+  +R  KL    +  L      D +  W+G  E+SLK       + +++Q ++
Sbjct: 2052 YEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDII 2111

Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
            +K    +  +   Q    ++I A+ +++         +  +   + MK  S   + ++ +
Sbjct: 2112 SKNIMLEQDIAGRQ----SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 2167

Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
             K+ L      +   +LF   ++K   F      A  ++  P +     ++  L +    
Sbjct: 2168 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGK-----DVTELSQYMQE 2222

Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQK 2200
              S     +     L  L ++I S  + S+         LE+T  NL K  KE E  +++
Sbjct: 2223 STSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL-----VLEKT-NNLSKKFKEMEDTIKE 2276

Query: 2201 EQRRQEENDKLRQEFAQHANAFHQWIQET--RTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
            ++       +    F     +   WI+ET  +  ++  S   E+ G     LE TK+  +
Sbjct: 2277 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLEDTKKLQE 2333

Query: 2259 EIRAMRSQLKKIEDLGAAM 2277
            +      +++K+ + G ++
Sbjct: 2334 KWSLKTPEIQKVNNSGISL 2352



 Score =  102 bits (255), Expect = 4e-21
 Identities = 450/2452 (18%), Positives = 904/2452 (36%), Gaps = 352/2452 (14%)

Query: 30   KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ--IASDENYKDPTNLQGKLQKHQA 87
            K L+T R Q+        F  R   EL  W+ EK +  +A D + ++ TN+  K   H  
Sbjct: 686  KLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEEEVAYDWSERN-TNIARKKDYHAE 743

Query: 88   FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQ 147
               E+      I  + E    ++ E H A  TI      +  QW  +L+           
Sbjct: 744  LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ----------L 793

Query: 148  AQKLVQYLRECEDVMDWIND-KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
             Q + Q+++E     ++ ND KEA      L       + +Q+K+           +R +
Sbjct: 794  CQCVEQHIKENTAYFEFFNDAKEATDYLRNL------KDAIQRKYS---------CDRSS 838

Query: 207  EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK---LFGAAEVQRF--N 261
             +++    + +    +EEL++ K    N   +    + L+ +     L  +  ++     
Sbjct: 839  SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 898

Query: 262  RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL 321
            R ++ TI   K+ E ++A++        +                 E  V ++C      
Sbjct: 899  RQIEITI--YKDDECVLANNSHRAKWKVISP------------TGNEAMVPSVCFTVPPP 944

Query: 322  QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF-RDLTSWVTEM 380
             +     A +I+ + + ++T W        E H  +         + +  R   S V  +
Sbjct: 945  NKEAVDLANRIEQQYQNVLTLWH-------ESHINMKSVVSWHYLINEIDRIRASNVASI 997

Query: 381  KALINADE---LASDVAGAEALLDRHQEHK----GEIDAHEDSFKSADESGQALLAAGHY 433
            K ++  +    L++  +  E  L+  QE +     +I   E       +  Q LL +   
Sbjct: 998  KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 1057

Query: 434  ASDEVREKLTVLSEERAALLELWELRRQQYEQCM------DL-QLFYRDTEQVDNWMSKQ 486
               E       +SE R   L L     +   Q        DL +  +R TEQ      K+
Sbjct: 1058 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE---KLKK 1114

Query: 487  EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
            E   L +DLG        +  K E+F  S +A    +  L      ++QN +      +T
Sbjct: 1115 ELERLKDDLG-------TITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 1166

Query: 547  RRDAL----LSRRNALHERAM---------RRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
              D L    L  +N     A+            A +AD  +++       + +S V+EK 
Sbjct: 1167 YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1226

Query: 594  K---TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKL-IDVNHYAKD-- 647
            +      DE  K  +      + ++  + +   ++ + D L +  Q + + +++  +D  
Sbjct: 1227 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 1286

Query: 648  ------EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHL 701
                  +        +  W + +E T+ K I+  +    +     +   ++ + E+E   
Sbjct: 1287 GIGKSLKYYRDTYHPLDDWIQQVETTQRK-IQENQPENSKTLATQLNQQKMLVSEIEMKQ 1345

Query: 702  AS-DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQE 760
            +  D+  K         K + L      A  D      ++ R+ Q +    A+ I ++  
Sbjct: 1346 SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS----ADLIIQEFM 1401

Query: 761  ALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGV 819
             L  RY AL   M    +   DSL RL++  + +E+E     +KE +  +    K +  +
Sbjct: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-----KKEHVEKAKELQKWVSNI 1456

Query: 820  QNLLKKHQALQAEIAGHEP--RIKAVTQKGNAMVEEGHFAAEDVKAKL------------ 865
               LK      AE AG  P  + K  +++ +   E+   A + ++  L            
Sbjct: 1457 SKTLK-----DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1511

Query: 866  HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE-----KEPIVGSTDYGK 920
            +EL ++ + L+   +    +    LQ  Q   D    E  + E     KE + G  D   
Sbjct: 1512 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLT 1571

Query: 921  DEDSAEALLKKHEALM-----SDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLAL 975
              ++   L+   EA M      +L  Y S  + L++  Q   Q +A    E  K     L
Sbjct: 1572 QTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA----EVVKNTENFL 1625

Query: 976  YDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035
             +  EK  +E    K  I   LN       ++ +   Q        K+LD   + +   +
Sbjct: 1626 KENGEKLSQE---DKALIEQKLNEAKIKCEQLNLKAEQS------KKELDKVVTTA---I 1673

Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
             EE   +A  ++  +++T+I      +S   K  E         G K K ++E++   F 
Sbjct: 1674 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE-------RAGTKHKQVIEQNGTHF- 1725

Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK-DINKVA 1154
                     Q  + K A    +EV  +L + +V   +    Q++L     ++K    K+ 
Sbjct: 1726 ---------QEGDGKSAIGEEDEVNGNLLETDV-DGQVGTTQENLNQQYQKVKAQHEKII 1775

Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
               ++  +  +  Q + +++   + P ++   +                   ++KEL   
Sbjct: 1776 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ------------------KNMKELKVH 1817

Query: 1215 WRSLQQLAEERSQLLGS-AHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQ 1272
            + +    +E++ +L  S   E+++F  D  E + W+++  Q L N +    D+  +    
Sbjct: 1818 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1877

Query: 1273 RKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE-------------DLQEKCTELNQ 1319
            ++ + F  D+ +    +  +  +  R++++    ++             ++Q K      
Sbjct: 1878 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1937

Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVS---SDELAKDVTGAE 1375
             + SL  + +     L D  D  +   D    L++ +       S   S+ +A D    +
Sbjct: 1938 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 1997

Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLL-AHGHY--ASPEIKQKLDILDQERADLEK 1432
              LE  +  + +I ++    +  ++  + LL A G    A  +I++ LD +     DL K
Sbjct: 1998 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2057

Query: 1433 AWVQRRMMLDQCLELQLFHRD-CEQAENWMAAREAFLNTE-----DKGDSLDSVEALIKK 1486
            +  +R   L   L   L  +D  ++  +WM   E+ L  +     +     D +   I  
Sbjct: 2058 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2117

Query: 1487 HEDF---DKAINVQEEKIAALQAFADQLIAAGHYAK-GDISSRRNEVLDRWRRLKAQMIE 1542
             +D      +IN   EK+       D   A+   AK  D+S+R +E   + +   A+M E
Sbjct: 2118 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2177

Query: 1543 KRSKLGESQTLQQFSRDVDEIEAWISEKLQ--TASDESYKDPTNIQ--LSKLLSKHQKHQ 1598
             ++K      ++ F    ++++ ++  K Q  T  D   KD T +   + +  S+  +H+
Sbjct: 2178 LKTK------VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2231

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
                 LH+               I        +  V  +   L+ +++ +     EK + 
Sbjct: 2232 KHLEVLHSLLKE-----------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 2280

Query: 1659 LKEANKQQN-FNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLLKKHQLLEA 1710
            +    +Q + F   +K    W+ E       V+    +ED GK L     L +K  L   
Sbjct: 2281 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2340

Query: 1711 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTING--------RFQKIKSMAASRR 1762
            +I    +    L     S +T+ A   + VK     +NG         F   K + + ++
Sbjct: 2341 EIQKVNNSGISL-CNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2399

Query: 1763 AKLNESHRLHQFFRDMDDEESWIKEK--KLLVGSEDYGRDLTGVQNLRK----------- 1809
               + SH        + D+ + +  K  KL    E+    +  +Q + K           
Sbjct: 2400 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2459

Query: 1810 -----------KHKRLEAELAAHEPAIQGVLDTGKKLSDDN--TIGKEEIQQRLAQFVEH 1856
                       ++K  EAEL  +   +Q + D   +L ++N  T      +Q L +    
Sbjct: 2460 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2519

Query: 1857 WKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL- 1914
            W+EL QL   R Q+LEES     QF     + + W+ EK  +V+       L+    +L 
Sbjct: 2520 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS---VLGPLSIDPNMLN 2576

Query: 1915 ---KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE----------NISSKMKGLNG 1961
               ++ +    +F   K +   +   GQ ++ +                 ++ K   L G
Sbjct: 2577 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2636

Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
            ++SD      Q   K  +  + L               +  S K  D    LSS   + T
Sbjct: 2637 QLSDRCDWIDQAIVKSTQYQSLL---------------RSLSDKLSDLDNKLSSSLAVST 2681

Query: 2022 KQETFDAGLQAFQQEGIANITALKDQLLAAKHV---QSKAIEARH--ASLMKRWSQLLAN 2076
              +  +  L+  Q+     I   K Q+  A+ +    S  ++  +  A L ++   +L +
Sbjct: 2682 HPDAMNQQLETAQKMK-QEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2740

Query: 2077 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE--NAEEDLTDPVRCNSLEEIKAL 2134
                ++K      H +        F + +  F +W +    E++ + P+    L+ +++L
Sbjct: 2741 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA-KLDVLESL 2799

Query: 2135 REAHDAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
             + H  F  +L++    + + +AE +  +   + +        +  ++  W    K +KE
Sbjct: 2800 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2859

Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLD-GSCMVEESGTLESQLEA 2252
            RE +L       +E+ +   ++ +       WI + +  L +   C+    G  E+ +  
Sbjct: 2860 RENKL-------KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG--ENSIAK 2910

Query: 2253 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQ 2304
             K   +E+      ++ + +   ++     +D +        L Q+ D + +
Sbjct: 2911 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 2962



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 87/439 (19%), Positives = 179/439 (40%), Gaps = 52/439 (11%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIASDENY 72
            + +   ++ D++      S  R+ KLE++  F     DA + L  W+   + Q+A D+  
Sbjct: 4698 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4757

Query: 73   KDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
                +L    +  H+AF+ E+   + ++  L  +   +I      S  ++ ++ EL  +W
Sbjct: 4758 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4817

Query: 132  ELLLEKMREKGIKLLQAQKLVQYLRECED-------VMDWINDKEAIVTSEE-LGQDLEH 183
            E +        + + +  +L   LR+ E+       +++W+ + E  +     L  D + 
Sbjct: 4818 ETVC------ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4871

Query: 184  VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEE-ELIKTKQDEVNAAWQRLKG 242
            +  L  + +EF   +      +N+       ++   HP+    IK     + A ++ +  
Sbjct: 4872 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4931

Query: 243  LALQRQGKLFGAAEVQRFNRDVDETI-SWIKEKEQLMASDD---FGRDLASVQALLRKHE 298
             A Q Q +L  A       +++ E + +W++  E  +   D     +++  V+AL+ +H+
Sbjct: 4932 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 4991

Query: 299  GLERDLAALE---DKV----KALCAEADRLQQSHPL--------------------SATQ 331
                ++   +   DKV    K   A+   LQ   P+                    S TQ
Sbjct: 4992 TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQ 5051

Query: 332  IQVKREE---LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
            I+ K      L++ W+Q+  LA ER  +LND+      L +F +    +   K +   + 
Sbjct: 5052 IETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNH 5111

Query: 389  LASDVAGAEALLDRHQEHK 407
              S V      +D+ Q+ K
Sbjct: 5112 KKSRVMDFFRRIDKDQDGK 5130



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 64/276 (23%), Positives = 114/276 (41%), Gaps = 12/276 (4%)

Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
           +DL +WV EM+  ++  E  SD+   E+ L+ H+     I+  E S K A  S   + A 
Sbjct: 609 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 668

Query: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
                    EKL  L  + A LL      R Q      L  F         W++++E   
Sbjct: 669 ---LKLTYAEKLHRLESQYAKLL---NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 722

Query: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
           +  D  +   ++      H +  + L  +EE I ++ E A +L+  NH A   +   R A
Sbjct: 723 VAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 782

Query: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK-DPSN--- 606
           + ++ + + +        + ++    +FF D+ E   ++   +K A    Y  D S+   
Sbjct: 783 MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL-RNLKDAIQRKYSCDRSSSIH 841

Query: 607 -LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDV 641
            L+  VQ+    + EL   +S I  L    + +I +
Sbjct: 842 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 877



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 22/279 (7%)

Query: 145 LLQAQKLVQYLRECE-------DVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTD 197
           LL++  L Q L E E       D+++W+++ +  +   E G DL  VE      E  +  
Sbjct: 588 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE---SHLENHKNV 644

Query: 198 MAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 257
             A EE  + + +     IQ   P +     K   + + + +L   +  ++  L     +
Sbjct: 645 HRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTL 701

Query: 258 QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAE 317
             F       + W+ EKE+   + D+     ++      H  L R+L   E+ +K++   
Sbjct: 702 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 761

Query: 318 ADR-LQQSHPLSATQIQVKREELITNWEQIRTL--AAERHARLNDSYRLQRFLADFRDLT 374
           A++ L ++HP   T I+  R  + T W  I  L    E+H + N +Y    F  D ++ T
Sbjct: 762 AEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQCVEQHIKENTAY--FEFFNDAKEAT 818

Query: 375 SWVTEMKALIN---ADELASDVAGAEALLDRHQEHKGEI 410
            ++  +K  I    + + +S +   E L+    E K E+
Sbjct: 819 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 857


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  278 bits (711), Expect = 5e-74
 Identities = 415/1966 (21%), Positives = 824/1966 (41%), Gaps = 178/1966 (9%)

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASET--IRTRLMELHRQ 130
            +D   LQ + +  +AF  +++A   +    ++T  +M++    + +   I+  L  L +Q
Sbjct: 2790 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 2849

Query: 131  WELLLEKM--REKGIK--LLQAQKLVQYLRECEDVMDWINDKEAI-----VTSEELGQDL 181
               LL++   RE+ ++  + + ++    L+E   ++    + E       + +E + Q L
Sbjct: 2850 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 2909

Query: 182  EHVEVLQKKFEEFQTDMAAHEERVNEVNQ----FAAKLIQEQHPEEELIKTKQDEVNAAW 237
               +V QK  EE +  +   ++ VN + Q     AAK    Q  E +L     D+VNA W
Sbjct: 2910 NMFKVFQK--EEIEP-LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL-----DDVNARW 2961

Query: 238  QRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDLASVQALLR 295
            + L     QR  +L  A     RF   ++  +SW+ + E+L+A+      +   V+A ++
Sbjct: 2962 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3021

Query: 296  KHEGLERDLAALEDKVKALCAEADRLQQS-HPLSATQIQVKREELITNWEQIRTLAAERH 354
            + + L+R L   +  V+ +  E +++  +  P    +I  +   L + WE +   A  R+
Sbjct: 3022 EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN 3081

Query: 355  ARLND-SYRLQRFLADFRDLTSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDA 412
             +L   S   Q+F      L  W+T + K L+N + + +  +  E  + +H+  + +I  
Sbjct: 3082 RQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIIN 3141

Query: 413  HEDSFKSADESGQAL-LAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-DLQ 470
            H      A   GQ+L + +     D V+ KL         + E    R +  +Q + + +
Sbjct: 3142 HNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAK 3201

Query: 471  LFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDF----EKSLSAQEEKITAL 526
            +F  D  ++ NW+++    L    + D   S E L K+  +     E  L  ++    AL
Sbjct: 3202 IFGEDEVELMNWLNEVHDKLSKLSVQDY--STEGLWKQQSELRVLQEDILLRKQNVDQAL 3259

Query: 527  DEFATKLIQNNHYAMEDVATRRDALLSRRNALHE------RAMRRRAQLADSFHLQQFFR 580
                  L Q     +  +  + +A+ +R   + +      + + +  QLA   H      
Sbjct: 3260 LNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTH--- 3316

Query: 581  DSDELKSWVNE---KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
              +EL +W+++   ++ +   +  K     Q +++  +  + E   N++ +D+L +    
Sbjct: 3317 --EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNEVSSA 3373

Query: 638  LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREAN--QQQQFNRNVEDIELWLY 695
            L+++  +   E   +M    +   +L+  T  + ++  +A   + QQF++  +    W+ 
Sbjct: 3374 LLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWIT 3433

Query: 696  EVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA-GHFD 751
            E E  L S       +D T+ Q   +K   +E  +  H+D ID +     +   A    +
Sbjct: 3434 ETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHKIMTACSEEE 3491

Query: 752  AENIKKKQEALVARYEALKEPMVARKQKL--ADSLRLQQLFRDVEDEETWIREKEPIAAS 809
             +++KKK + ++  Y+ + +    R  +L  A SL + Q +   E+   W+ E + I + 
Sbjct: 3492 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSL-VNQFWETYEELWPWLTETQSIISQ 3550

Query: 810  TNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
                  +   ++   ++H+ L+  IA H+P I  + + G  ++E        ++ K    
Sbjct: 3551 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA 3610

Query: 869  NQKWEALKAKASQRRQDLEDSLQAQQYFADANEA--ESWMREKEPIVGSTDYGKDEDSAE 926
            +  +  +K    +R   L++++     F D  +   ES  R  E +        + +  +
Sbjct: 3611 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 3670

Query: 927  ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQ----EKS 982
              + +++ +  D+       + L+++ +    +   TD +   + V    D      E  
Sbjct: 3671 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 3730

Query: 983  PREVTMKKGDILTLLNSTNKDWWK-----VEVNDRQGFVPAAYVKKLDPA----QSASRE 1033
               V  ++  +L ++    K W       V + D Q F+       +DP+    Q  + E
Sbjct: 3731 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 3790

Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVS------LRMKQVEEL---YHSLLELGEKRK 1084
             + EE   +   QE++D    +  E  +        +  K ++EL   + SL +  + R 
Sbjct: 3791 TIREEIDGL---QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 3847

Query: 1085 GMLEKSCKKFMLFREANE-LQQWINEKEAALTS-EEVGADLEQVEVLQKKFDDFQKDLKA 1142
              LE++ +  + +++  + +  W++     L S   +G DLE V+   ++   F+ +   
Sbjct: 3848 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 3907

Query: 1143 NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTV 1202
             +  ++ +N  AE      L+ ++V              +E+D              HTV
Sbjct: 3908 QQIEMERLNHQAE------LLLKKVT-------------EESDK-------------HTV 3935

Query: 1203 ATFNSIKELNERWRSLQQ-LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN- 1260
               + + EL   W SL++ +   + +L G+   + +F    DE   W+      L+    
Sbjct: 3936 Q--DPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 3993

Query: 1261 YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTELNQ 1319
             G D  +++    KH   + D+ A    V ++ +    LI+S   E A +LQ K   LNQ
Sbjct: 3994 VGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQ 4053

Query: 1320 AWSSLGKRADQRKAKL-GDSHDLQRFLSDFRDLMSWINGI-RGLVSSDELAKDVTGAEAL 1377
             W ++ ++ +QRK +L G     + F  +  DL  W+    R L++S  L      A+  
Sbjct: 4054 RWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQ 4113

Query: 1378 LERHQEHRTEIDARAGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQ 1436
            L  H E     +A+  T+++  Q GQQ+LA     A   I Q ++ L ++   +E    +
Sbjct: 4114 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4173

Query: 1437 RRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAI 1494
            R+  L++ L L + FH   +   NW+   E  LN   +    LD+V   I +H+ F   +
Sbjct: 4174 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4233

Query: 1495 NVQEEKIAALQAFADQLIAAGHYAKGDISSRRN---EVLDRWRRLKAQMIEKRSKLGESQ 1551
            N   E+I  L      L       K D+   +N    V  RW ++  +++E+   L +++
Sbjct: 4234 NSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4291

Query: 1552 T-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANA 1608
               +QF     ++  W+  SEK   +  E   DP  I+    L++H++ Q      H+  
Sbjct: 4292 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ--LAQHKEFQKSLGAKHSVY 4349

Query: 1609 DRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK-QQN 1667
            D        G SL E+ + A     +   L+ L D+W  +  KS E+  KL+EA      
Sbjct: 4350 DTTNRT---GRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4406

Query: 1668 FNTGIKDFDFWLSEVEALLASED--YGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1725
            F   ++    WL  VE  LA +   +G D+  V NL+  H+  + ++      ++ L   
Sbjct: 4407 FTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4465

Query: 1726 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR--------LHQFFRD 1777
            A  L+  S  D+S VK +   ++ R++ + +++ S++ +L  + R        +H     
Sbjct: 4466 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4525

Query: 1778 MDDEESWIKEKKLLVGSEDYGRDLTGV-QNLRKKHKRLEAELAAHEPAIQGVL-----DT 1831
            + + E  ++   +L   ED  R L    +   KK +   AEL         VL     D+
Sbjct: 4526 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 4585

Query: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA---ARGQRLEESLEYQQFVANVEEEE 1888
               +    TI +   ++ LA   +H + L    A   A+ + LE  L + Q         
Sbjct: 4586 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQ--------- 4636

Query: 1889 AWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDV 1934
             W    +T    E     +  ++ L+ +H+ F  + T  +  V+ V
Sbjct: 4637 -WAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKV 4681



 Score =  265 bits (676), Expect = 5e-70
 Identities = 503/2529 (19%), Positives = 1024/2529 (40%), Gaps = 298/2529 (11%)

Query: 49   FQRDAEELEKWIQEKLQIASDENYKDPTN-----LQGKLQKHQAFEAEVQANSGAIVK-L 102
            FQ+ + + + W+  K +   ++N   P +     L+  ++ H+ F   + A S    K +
Sbjct: 2439 FQQMSRDFQAWLDTKKE---EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2495

Query: 103  DETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQA-QKLVQYLRECEDV 161
             E  NL++         ++ +L  +   W+   ++++E+  KL ++ +K ++Y  + E +
Sbjct: 2496 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2555

Query: 162  MDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHP 221
              WI+  +  +   +   D    E    K +  Q +M  H   V  +N  A  L+     
Sbjct: 2556 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2615

Query: 222  EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKE-----KEQ 276
            ++E++    DE  +  Q++  +  Q   K F    + +  ++  E     K      KEQ
Sbjct: 2616 DKEVVT---DENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQ 2672

Query: 277  LMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR 336
            L   D  G    S    L   +  ++ L AL+ +V      A RL Q   + A+  +   
Sbjct: 2673 LDIHDSLGSQAYS-NKYLTMLQTQQKSLQALKHQVDL----AKRLAQDLVVEASDSKGTS 2727

Query: 337  EELITNWEQIRTLAAERHARLNDSY---------RLQ---RFLADFRDLTSWVTEMKALI 384
            + L+    Q+ T+A E H+ L+            +LQ    F    R++ S   E    +
Sbjct: 2728 DVLL----QVETIAQE-HSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDEL 2782

Query: 385  NADELASDVAGAEALLDRHQEHKG---EIDAHEDSFKSADESGQALLAAGHYASDEV--R 439
              D +A     AE L  + +  K    +++A   S  +A+++ + +LA    + D V  +
Sbjct: 2783 --DSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 2840

Query: 440  EKLTVLSEERAALLELWELRRQQYEQCMD-LQLFYRDTEQVDNWMSKQEAFLLNED-LGD 497
              L  LS++   LL+  + R +Q E  +  L+ FY   ++    + K E    ++  +G 
Sbjct: 2841 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 2900

Query: 498  SLDSVEALLKKHEDFEKS----LSAQEEKITALDEFATKLIQNNHYAMEDVATRR----- 548
              +++   L   + F+K     L  +++ +  L +    LIQ+   A +  +T+      
Sbjct: 2901 ETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ---GLIQS---AAKSTSTQGLEHDL 2954

Query: 549  DALLSRRNALHERAMRRRAQLADSF-HLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN- 606
            D + +R   L+++  +R AQL ++  H  +F    + L SW+ +  +   ++  K PS  
Sbjct: 2955 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQ--KPPSAE 3012

Query: 607  ---LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA-KDEVAARMNEVISLWKK 662
               ++ ++Q+ +  +  L   +S ++ +++ G+K+      A K ++  +++ + S W+ 
Sbjct: 3013 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3072

Query: 663  LLEATELKGIKLREANQ-QQQFNRNVEDIELWLYEVEGHLAS-DDYGKDLTNVQNLQKKH 720
            LL   E +  +L   +   QQF+  +E +  WL  +E  L + +  G   + ++    +H
Sbjct: 3073 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3132

Query: 721  ALLEADVAAHQDRI-DGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQK 779
              LE D+  H   +   ++I       +   D + ++ K +     Y  ++E   +R + 
Sbjct: 3133 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3192

Query: 780  LADSLRLQQLFRDVEDE-ETWIRE-KEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHE 837
            L  +L   ++F + E E   W+ E  + ++  + +     G+     + + LQ +I   +
Sbjct: 3193 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3252

Query: 838  PRIKAVTQKGNAMVEEGHFAAEDV---KAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQ 893
              +      G  ++++     ++V   + KL  +  +++ +   ++   + LE +LQ A+
Sbjct: 3253 QNVDQALLNGLELLKQT--TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3310

Query: 894  QYFADANEAESWMR--EKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
            +  +   E  +W+   E E +   T   K E++++A ++  E L  +     + + +L E
Sbjct: 3311 RLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE-LKKEAKNNKALLDSLNE 3369

Query: 952  QAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVND 1011
               S   ++ P     G E ++A              +  +   L++ T     KVE  D
Sbjct: 3370 -VSSALLELVPWRAREGLEKMVA--------------EDNERYRLVSDTITQ--KVEEID 3412

Query: 1012 RQGFVPAAYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITK------------ 1057
                    + +  D   S     E  L   G I L Q+Q   Q ++ K            
Sbjct: 3413 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3472

Query: 1058 ------------------EAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFRE 1099
                              E  S+  ++ +V + Y ++ ++  +R   LE++      F E
Sbjct: 3473 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3532

Query: 1100 A-NELQQWINEKEAALTSEEVGA-DLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDL 1157
               EL  W+ E ++ ++     A + E +   Q++    ++ +  ++  +  +NK    L
Sbjct: 3533 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3592

Query: 1158 ----ESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNE 1213
                  EG   +E + V    +Y  +  D              +    VA   +I +  +
Sbjct: 3593 LELSPGEGFSIQE-KYVAADTLYSQIKED--------------VKKRAVALDEAISQSTQ 3637

Query: 1214 RWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQR 1273
                + Q+ E   +++    +      + ++ KE I E        N   D+  +Q L  
Sbjct: 3638 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK------NVSVDMEKLQPLYE 3691

Query: 1274 KHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKA 1333
                    L   G+++ +     ++ I     SA+ +Q+K  ++   W ++    ++R+A
Sbjct: 3692 T-------LKQRGEEMIARSGGTDKDI-----SAKAVQDKLDQMVFIWENIHTLVEEREA 3739

Query: 1334 KLGDSHDL-QRFLSDFRDLMSWINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDAR 1391
            KL D  +L ++F  D   L+  I   +  +   ++   D +  +   E  +  R EID  
Sbjct: 3740 KLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGL 3799

Query: 1392 AGTFQAFEQFGQQLLAH-GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF 1450
                      G +L+A  G    P +K+ +D L+     L KAW  R   L++ ++  + 
Sbjct: 3800 QEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQ 3859

Query: 1451 HRDCEQAE-NWM-AAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFA 1508
            ++D  QA  +W+  A     +    G  L++V+  I++ + F      Q+ ++  L   A
Sbjct: 3860 YQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQA 3919

Query: 1509 DQLI--AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEA 1565
            + L+        K  +     E+   W  L+ ++I ++ KL G    L QF   +DE+ A
Sbjct: 3920 ELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLA 3979

Query: 1566 WIS--EKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIE 1623
            W++  E L +       DP  I++        KH   + ++ A+   +  V   GN LIE
Sbjct: 3980 WLTHTEGLLSEQKPVGGDPKAIEIELA-----KHHVLQNDVLAHQSTVEAVNKAGNDLIE 4034

Query: 1624 RGACAGSEDA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ-QNFNTGIKDFDFWLSE 1681
              + AG E + ++ +L  L  +WQ +++K+ ++ Q+L  A +Q + F+  I+D   WL++
Sbjct: 4035 --SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4092

Query: 1682 VEA-LLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDT-SQ 1739
             E  LLAS+  G    +    L  H  + A   A E+  K L  +   ++        + 
Sbjct: 4093 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4152

Query: 1740 VKDKRDTINGRFQKIKSMAASRRAKLNESHRLH-QFFRDMDDEESWIK--EKKLLVGSED 1796
            +    + +  +++ +++    R+ KL E+  L  +F   + D  +W+   E+ L V S  
Sbjct: 4153 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4212

Query: 1797 YGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE---IQQRLAQF 1853
                L  V     +HK    E+ +H   I  +  TG  L   +   K++   I+  L   
Sbjct: 4213 -SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISV 4269

Query: 1854 VEHWKELKQLAAARGQRLEESLEY-QQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQ 1911
               W+++ Q    RG+ L+++ +  +QF     +   W+ E    + SE +  +    I+
Sbjct: 4270 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIK 4329

Query: 1912 GLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENIS--SKMKGLNGKVSDLEKA 1969
              L +H+ F+          +     G+ L +K +  ++N+     +  L  K   +   
Sbjct: 4330 TQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGK 4389

Query: 1970 AAQRKAKLDENSAFL-QFNWKADVVESWIGEKENSLKTDD--YGRDLSSVQTLLTKQETF 2026
            + +R+ KL+E   F  QF      +  W+   E  L  D   +G D+  V  L+   + F
Sbjct: 4390 SVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAF 4448

Query: 2027 DAGLQAFQQEGIANITALKD---QLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKK 2083
               L     +  +++ ALK    +L+      S  ++ +   L  RW  + A S +++ +
Sbjct: 4449 QKELG----KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR 4504

Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLT-DPVRCNSLEEIKALREAHDAFR 2142
            L   ++  R+ E+    F     A   W   AE+ L    V  +  + ++ L + H  F 
Sbjct: 4505 L---EAALRQAEE----FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4557

Query: 2143 SSLSSAQADFNQLAELDRQIKSFRVASNPYT---WFTM------EALEETWRNLQK---- 2189
              L   +A+ N+   +   + +     +  T   W T+      E L    ++ Q+    
Sbjct: 4558 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4617

Query: 2190 ----IIKERELELQKEQRRQEEN---DKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEE 2242
                I K+  LE      +  E    DK ++   Q        I E +T++ +   M  +
Sbjct: 4618 LAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEE---MTRK 4674

Query: 2243 SGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVG-------- 2294
               ++   +  KR+  +  +++S +  + D G A  +     + Y   S           
Sbjct: 4675 QPDVDKVTKTYKRRAADPSSLQSHIPVL-DKGRAGRKRFPASSLYPSGSQTQIETKNPRV 4733

Query: 2295 --LAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM---------------- 2336
              L  +W Q+  L +  +  L   +          E L+EF+                  
Sbjct: 4734 NLLVSKWQQVWLLALERRRKLNDALDRL-------EELREFANFDFDIWRKKYMRWMNHK 4786

Query: 2337 -------FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDG 2389
                   F+  DKD+ G++  QEF   + S  +    +       E  A+ D  D + DG
Sbjct: 4787 KSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL-------EMSAVADIFDRDGDG 4839

Query: 2390 HVSLQEYMA 2398
            ++   E++A
Sbjct: 4840 YIDYYEFVA 4848



 Score =  233 bits (594), Expect = 2e-60
 Identities = 446/2453 (18%), Positives = 976/2453 (39%), Gaps = 266/2453 (10%)

Query: 21   QVLDRYHRFKELSTLRRQKLEDSYR-FQFFQRDAEELEKWIQEKLQIAS--DENYKDPTN 77
            ++  ++    +L+  R+QKLE+S      FQ    +L++W+ EK  + S       DP  
Sbjct: 2189 EIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNM 2248

Query: 78   LQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTRLMELHRQWELL 134
            L  + Q+ Q    E         +L   G  ++S   E       ++ +L  + ++W+ L
Sbjct: 2249 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2308

Query: 135  LEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSEE-LGQDLEHVE 185
              ++ ++        +K  Q Q L++ L +   D+ + ++   A+ T  + + Q LE  +
Sbjct: 2309 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2368

Query: 186  VLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNA---AWQRLKG 242
             ++++ ++ +  +   +    +++     L++E++ + EL +  +  + +     Q+ + 
Sbjct: 2369 KMKQEIQQEKKQIKVAQALCEDLSA----LVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2424

Query: 243  LALQRQGKLFGAAEVQRFNRDVDETISWIK-EKEQLMASDDFGRDLASVQALLRKHEGLE 301
                 Q     + + Q+ +RD     +W+  +KE+   S      L  +++L++ H+   
Sbjct: 2425 HVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2481

Query: 302  RDLAALEDKVKALCAEADRL---QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLN 358
            + L A     +   AE + L    Q    +A Q+Q+    + TNW+       ER  +L 
Sbjct: 2482 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT--IKTNWDTFNKQVKERENKLK 2539

Query: 359  DSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSF 417
            +S  +  ++      L  W+ + +  +   +   D A  E  + + +  + E+D H    
Sbjct: 2540 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2599

Query: 418  KSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQ---CMD-LQLFY 473
            +  + +  +LL+      +       V+++E  +L++  ++  +Q      C++ +   +
Sbjct: 2600 ELLNNTANSLLSVCEIDKE-------VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKF 2652

Query: 474  RDTEQVDNWMSKQEAFLLNE-DLGDSLDSVEALLKKH----EDFEKSLSAQEEKITALDE 528
            ++ ++V     +Q      + D+ DSL S +A   K+    +  +KSL A + ++     
Sbjct: 2653 KEFQEVSKESKRQLQCAKEQLDIHDSLGS-QAYSNKYLTMLQTQQKSLQALKHQVDLAKR 2711

Query: 529  FATKLI--QNNHYAMEDVATRRDALLSRRNALHERAMRR----RAQLADSFHLQQFFRDS 582
             A  L+   ++     DV  + + +    + L ++   +      +L    H Q   R+ 
Sbjct: 2712 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 2771

Query: 583  DELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVN 642
                +  ++++ +      +D   LQ + +  +AF  +L A  +  D   K  + ++   
Sbjct: 2772 FSQFAEFDDELDSMAPVG-RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATE 2830

Query: 643  HYAKDEVAARMN-EVISLW-KKLLEATELKGIKLREANQQ-QQFNRNVEDIELWLYEVEG 699
              + D V  + + E +S    KLL+  + +  ++    ++ ++F   +++  + L + E 
Sbjct: 2831 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 2890

Query: 700  HLASDD-YGKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQF--QDAGHFDAENI 755
            H  S    G +   + Q L       + ++   Q +   +    +      A     + +
Sbjct: 2891 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 2950

Query: 756  KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-VEDEETWIREKEPIAASTNR-G 813
            +   + + AR++ L + +  R  +L ++L     F+D +E   +W+ + E + A+     
Sbjct: 2951 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS 3010

Query: 814  KDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQK 871
             +   V+  +++ + LQ  +   +  ++ + ++G  +       A+ VK   +L  L+ +
Sbjct: 3011 AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE-PADKVKILKQLSLLDSR 3069

Query: 872  WEALKAKASQRRQDLED-SLQAQQYFADANEAESWMREKEP-IVGSTDYGKDEDSAEALL 929
            WEAL  KA  R + LE  S+ AQQ+         W+   E  +V     G      E  +
Sbjct: 3070 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3129

Query: 930  KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMK 989
             +H+AL  D+  +   +     QA S  Q +        K++V +  D+ +    E+  K
Sbjct: 3130 AQHKALEDDIINHNKHLH----QAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3185

Query: 990  KGDILTLLNST-------NKDW-----WKVEVNDRQGFVPAAYVKKLDPAQSASRENLLE 1037
                  LL           +D      W  EV+D+        + KL   Q  S E L +
Sbjct: 3186 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDK--------LSKLS-VQDYSTEGLWK 3236

Query: 1038 EQGS-------IALRQEQID----NQTRITKEAGS-----VSLRMKQVEELYHSLLELGE 1081
            +Q         I LR++ +D    N   + K+        +  +++ ++  Y  + +L  
Sbjct: 3237 QQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST 3296

Query: 1082 KRKGMLEKSCKKFMLFREANE-LQQWINEKEAALTSEEV----GADLEQVEVLQKKFDDF 1136
                 LE++ +        +E L  W+++ E  L S E     G +  Q ++  K   + 
Sbjct: 3297 DVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK---EL 3353

Query: 1137 QKDLKANESRLKDINK--------------------VAEDLESEGLMAEEV-QAVQQQEV 1175
            +K+ K N++ L  +N+                    VAED E   L+++ + Q V++ + 
Sbjct: 3354 KKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDA 3413

Query: 1176 YGMMPRD-------------ETDSKTAS--------PWKSARLMV--------------- 1199
              +  +              ET+ K  S           SA+L V               
Sbjct: 3414 AILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3473

Query: 1200 -------HTVATFNSIKELNERWRSLQQL-----------AEERSQLLGSAHEVQRFHRD 1241
                   H + T  S +E     + L ++           +E   QL  +   V +F   
Sbjct: 3474 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3533

Query: 1242 ADETKEWIEEKNQALNT-DNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLI 1300
             +E   W+ E    ++       +  +++  Q +H      +A     ++ + +T  +L+
Sbjct: 3534 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3593

Query: 1301 QSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRD--LMSWINGI 1358
            +  P     +QEK    +  +S + +   +R   L ++        D  D  L S    +
Sbjct: 3594 ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIV 3653

Query: 1359 RGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
              L     ++ +V   +  +  ++    +++     ++  +Q G++++A       +I  
Sbjct: 3654 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 3713

Query: 1419 KL--DILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAEN-WMAAREAFLNTEDKGD 1475
            K   D LDQ    +   W     ++++  E +L     E AE  W       +  +D  D
Sbjct: 3714 KAVQDKLDQ----MVFIWENIHTLVEE-REAKLLDV-MELAEKFWCDHMSLIVTIKDTQD 3767

Query: 1476 SLDSVE------ALIKKHEDFDKAIN-----VQEEKIAALQAFADQLIAAGHYAKGDISS 1524
             +  +E      +++K+ ++  + I      +QEE    +   ++ + A G   K  +  
Sbjct: 3768 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 3827

Query: 1525 RRNEVLDRWRRLKAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS---EKLQTASDESYK 1580
              +E+   W  L     ++  KL E+ Q   Q+   +  +  W+     KL + S     
Sbjct: 3828 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----- 3882

Query: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
             P    L  +  + ++ + F++E +     +  +      L+++      +  V+  L  
Sbjct: 3883 -PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 3941

Query: 1641 LADQWQFLVQKSAEKSQKLKEANKQQN-FNTGIKDFDFWLSEVEALLASED-YGKDLASV 1698
            L   W  L ++   +  KL+ A      F   + +   WL+  E LL+ +   G D  ++
Sbjct: 3942 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4001

Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFD-TSQVKDKRDTINGRFQKIKSM 1757
               L KH +L+ D+ AH+  ++ +N   + L+ SSA +  S +++K + +N R+Q +   
Sbjct: 4002 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4061

Query: 1758 AASRRAKLNESHRLHQFFR-DMDDEESWIK--EKKLLVGSEDYGRDLTGVQNLRKKHKRL 1814
               R+ +L+ + R  + F  +++D + W+   E+ LL      G   T  + L   H  +
Sbjct: 4062 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV-HMEV 4120

Query: 1815 EAELAAHEPAIQGVLDTGKK-LSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
             A   A E   + ++  G++ L+      +  I Q +    E W+ ++     R  +LEE
Sbjct: 4121 CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEE 4180

Query: 1874 SLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRV 1931
            +L    +F  ++++   W+ + + TL  +      L  +   + +H+ F  +   H++++
Sbjct: 4181 ALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQI 4240

Query: 1932 NDVCTNGQDLIKKNNHHEEN-ISSKMKGLNGKVSDLEKAAAQRKAKLDE-NSAFLQFNWK 1989
             ++   G  L   +   +   I + +  +  +   + +   +R   LD+      QF+  
Sbjct: 4241 IELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEA 4300

Query: 1990 ADVVESWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT-----A 2043
               +  W+ E E SL ++ +   D   ++T L + + F   L A  +  + + T     +
Sbjct: 4301 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA--KHSVYDTTNRTGRS 4358

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            LK++   A    +  ++   + L  +W  +   S  R+ KL EA     +  D       
Sbjct: 4359 LKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL----- 4411

Query: 2104 KASAFNSWFENAEEDLTD--PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
               A   W    E  L +  PV    ++ +  L + H AF+  L    +    L    R+
Sbjct: 4412 --QALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4468

Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANA 2221
            +       + +    M+ L   W  +  +   ++  L+   R+ EE       F    +A
Sbjct: 4469 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEE-------FHSVVHA 4521

Query: 2222 FHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
              +W+ E    L     + ++   L + ++  K   +++   R++L K   +G
Sbjct: 4522 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMG 4574



 Score =  226 bits (576), Expect = 2e-58
 Identities = 433/2280 (18%), Positives = 920/2280 (40%), Gaps = 246/2280 (10%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQF-FQRDAEELEKWIQEKLQIASDENY- 72
            +Q +   +   +  F +    R  KL++S      ++   E L  WI +      +  + 
Sbjct: 2513 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2572

Query: 73   KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
             DP   +  + K ++ + E+  + G +  L+ T N ++S      E +      L ++ +
Sbjct: 2573 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2632

Query: 133  LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWIND-----KEAIVTSEELGQDL---EHV 184
            ++ E++  K   L   + + Q  +E ++V           KE +   + LG      +++
Sbjct: 2633 MVTEQLHSKKFCL---ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 2689

Query: 185  EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEEL------IKTKQDEVNAAWQ 238
             +LQ +    Q  + A + +V+   + A  L+ E    +        ++T   E +   Q
Sbjct: 2690 TMLQTQ----QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 2745

Query: 239  RLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQ------- 291
            ++       + KL G    Q   R++    +   ++   MA    GRD  ++Q       
Sbjct: 2746 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP--VGRDAETLQKQKETIK 2803

Query: 292  ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKR--EELITNWEQIRTL 349
            A L+K E L     A  D     C      +++ P     + +KR  E L     ++   
Sbjct: 2804 AFLKKLEAL----MASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDR 2856

Query: 350  AAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEH-- 406
            A  R  ++  +  RL+ F +  ++ +  + + +      E +    G E      Q +  
Sbjct: 2857 AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE----HEESQGPVGMETETINQQLNMF 2912

Query: 407  ----KGEIDAHEDSFKSADESGQALLAAGHYAS---------DEVREKLTVLSEERAALL 453
                K EI+  +   +  +  GQ L+ +   ++         D+V  +   L+++ A   
Sbjct: 2913 KVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA--- 2969

Query: 454  ELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDS-LDSVEALLKKHEDF 512
               +   Q  E  +    F    E + +WM   E  + N+    +    V+A +++ +  
Sbjct: 2970 ---QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLL 3026

Query: 513  EKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-SRRNALHERAMRRRAQLAD 571
            ++ L  ++  +  +     K+      A +    ++ +LL SR  AL  +A  R  QL  
Sbjct: 3027 QRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3086

Query: 572  -SFHLQQFFRDSDELKSWVN--EKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRI 628
             S   QQF    + L  W+   EK     +      S L+ ++ +H+A E ++  +   +
Sbjct: 3087 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3146

Query: 629  DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNV- 687
                  GQ L  ++     ++     +   +W   +E  E K     E  QQ   N  + 
Sbjct: 3147 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW--YIEIQE-KSHSRSELLQQALCNAKIF 3203

Query: 688  --EDIEL--WLYEVEGHLAS---DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQ 740
              +++EL  WL EV   L+     DY  +   +   Q +  +L+ D+   +  +D   + 
Sbjct: 3204 GEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSELRVLQEDILLRKQNVDQALLN 3261

Query: 741  ARQF--QDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEE- 797
              +   Q  G  +   I+ K EA+ ARY+ + +      + L  +L+L +      +E  
Sbjct: 3262 GLELLKQTTGD-EVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3320

Query: 798  TWIR--EKEPIAASTN--RGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEE 853
            TW+   E E ++  T   +G++    Q   K+   L+ E   ++  + ++ +  +A++E 
Sbjct: 3321 TWLDKVEVELLSYETQVLKGEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLEL 3377

Query: 854  GHFAA-EDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE-SWMREKEP 911
              + A E ++  + E N+++  +    +Q+ ++++ ++   Q F  A +AE SW+ E E 
Sbjct: 3378 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3437

Query: 912  ---IVGSTDYGKDEDSAEALLKK--------HEALMSDLSAYGSSIQAL--REQAQSCRQ 958
                +G     +D+ SA+  ++K        H+ ++ DL   G  I      E+ QS ++
Sbjct: 3438 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3497

Query: 959  QVAPTDDETGKELVLALYDY--QEKSPREVTMKKGDILTLLNSTNKDW--------WKVE 1008
            ++         + VL  YD   Q  S R + +++   L      N+ W        W  E
Sbjct: 3498 KL---------DKVLKNYDTICQINSERYLQLERAQSLV-----NQFWETYEELWPWLTE 3543

Query: 1009 VNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITK--------EAG 1060
                   +PA  ++     Q       L E   IA  +  ID   +           E  
Sbjct: 3544 TQSIISQLPAPALEYETLRQQQEEHRQLREL--IAEHKPHIDKMNKTGPQLLELSPGEGF 3601

Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVG 1120
            S+  +    + LY  + E  +KR   L+++  +   F +  ++ Q +       + E + 
Sbjct: 3602 SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILE------SLERIV 3653

Query: 1121 ADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQ---QQEVYG 1177
              L Q   +  + +  ++ +  N++   D+ K+    E+     EE+ A      +++  
Sbjct: 3654 ERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISA 3713

Query: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAE----ERSQLLGSAH 1233
               +D+ D      W++    +HT+     ++E   +   + +LAE    +   L+ +  
Sbjct: 3714 KAVQDKLDQMVFI-WEN----IHTL-----VEEREAKLLDVMELAEKFWCDHMSLIVTIK 3763

Query: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
            + Q F RD ++                 G D + V+  Q   E    ++  L ++++ + 
Sbjct: 3764 DTQDFIRDLEDP----------------GIDPSVVKQQQEAAETIREEIDGLQEELDIVI 3807

Query: 1294 ETAERLIQSHPESAEDLQEKCT-ELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
                 LI +  E  + + +K   ELN AW SL K    R  KL ++     ++    + +
Sbjct: 3808 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 3867

Query: 1352 MSWINGIRG-LVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
              W++   G L S   +  D+   +  +E  ++ ++E   +    +      + LL    
Sbjct: 3868 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 3927

Query: 1411 YASPE--IKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAF 1467
              S +  ++  L  L      LE+  + R+  L+  L  L  F    ++   W+   E  
Sbjct: 3928 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 3987

Query: 1468 LNTEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
            L+ +   G    ++E  + KH      +   +  + A+    + LI +    +      +
Sbjct: 3988 LSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNK 4047

Query: 1527 NEVLD-RWRRLKAQMIEKRSKL-GESQTLQQFSRDVDEIEAWISE--------KLQTASD 1576
             EVL+ RW+ +  +  +++ +L G  +  + F  ++++++ W+++        K      
Sbjct: 4048 LEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLP 4107

Query: 1577 ESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGS-EDAVK 1635
            E+ K+  N+           H    A   A  +  + ++  G  ++ R  C  S E  + 
Sbjct: 4108 ETAKEQLNV-----------HMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNID 4154

Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALL-ASEDYGK 1693
              +  L ++W+ +  K  E+  KL+EA N    F+  ++DF  WL++ E  L  +     
Sbjct: 4155 QDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSL 4214

Query: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQ 1752
             L +V   + +H++   ++++H +++ +L+     L   S   D   +K+   ++  R++
Sbjct: 4215 ILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWE 4274

Query: 1753 KIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKEKKLLVGSE-DYGRDLTGVQNLRKK 1810
            K+      R   L+++  R  QF         W++E +  + SE +   D   ++    +
Sbjct: 4275 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4334

Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQ--QRLAQFVEHWKELKQLAAARG 1868
            HK  +  L A          TG+ L +  ++  + ++    L++  + W  +   +  R 
Sbjct: 4335 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4394

Query: 1869 QRLEESLEYQ-QFVANVEEEEAWINEKMTLVASED--YGDTLAAIQGLLKKHEAFETDFT 1925
             +LEE+L +  QF   ++    W+      +A +   +GD +  +  L+  H+AF+ +  
Sbjct: 4395 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD-IDLVMNLIDNHKAFQKELG 4453

Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ 1985
                 V  +  + ++LI+ +      +  +M+ L+ +   +   +  ++ +L+  +A  Q
Sbjct: 4454 KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLE--AALRQ 4511

Query: 1986 FNWKADVVES---WIGEKENSLKTDDY-GRDLSSVQTLLTKQETFDAGLQAFQQEGIANI 2041
                  VV +   W+ E E +L+       D  +++TL+ + + F   L+  + E +   
Sbjct: 4512 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAE-LNKA 4570

Query: 2042 TALKDQLLAAKHVQSKAIEARHASLMK-RWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
            T + D +LA  H  S        ++++ R+ ++LA +   +++L  A +     ++L   
Sbjct: 4571 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELL-- 4628

Query: 2101 FAKKASAFNSWFENAEEDLTDP---VRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
                  A  +W + AE  LTD    V    +EE+KAL   H  F   ++  Q D +++ +
Sbjct: 4629 -----EALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 4683



 Score =  188 bits (477), Expect = 6e-47
 Identities = 502/2586 (19%), Positives = 1010/2586 (39%), Gaps = 326/2586 (12%)

Query: 14   DIQERRQ---QVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEEL-EKWIQEKLQIAS 68
            ++ E+RQ    + D   + K +S  + +   E    F + +  A++L E+W    +QI  
Sbjct: 895  EVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI-- 952

Query: 69   DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
            D   +D   L+G  +  + +          I +++ T   +       S+T+ T+L    
Sbjct: 953  DNRLRD---LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---- 1005

Query: 129  RQWELLLEKMREKGIKLLQAQKLV-QYLRECEDVMDWINDKEAIVTSEELG-----QDLE 182
             Q ++L+ ++  K  K+ + QK   QY    +D         A+V S++       +   
Sbjct: 1006 NQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQS 1065

Query: 183  HVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE-LIKTKQDEVNAAWQRLK 241
              +++ ++F + +T   A    + +  +FA   ++    EE+ L + K++ V  A +  K
Sbjct: 1066 SADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQK 1125

Query: 242  GLA-LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH--- 297
             ++ + +  K    A    F++    +     +KEQL  +      L ++Q  L KH   
Sbjct: 1126 WVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEA------LQTIQLFLAKHGDK 1179

Query: 298  ------EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
                    LE+ +  L++    L +E+ +  Q    S T   VK EE I          A
Sbjct: 1180 MTDEERNELEKQVKTLQESYNLLFSESLKQLQE---SQTSGDVKVEEKIV---------A 1227

Query: 352  ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEID 411
            ER          Q +    + +   +T+ +  +   + A  +      L ++Q  + E+ 
Sbjct: 1228 ERQ---------QEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQ 1278

Query: 412  AHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQL 471
                  K    S QAL        + ++E    LS+E  AL+E  +   +   +C  L L
Sbjct: 1279 ------KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKIKCEQLNL 1330

Query: 472  FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
                 EQ     SK+E           LD V     K E  + +   Q E+     E   
Sbjct: 1331 ---KAEQ-----SKKE-----------LDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1371

Query: 532  KLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE 591
              + N     E   T+   ++ + N  H +    ++ + +   +     ++D +   V  
Sbjct: 1372 DWLSNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGEEDEVNGNLLETD-VDGQVGT 1429

Query: 592  KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA 651
              +    +  K  +  +  + +HQA    + A QS    LEK GQ L   +   K+++  
Sbjct: 1430 TQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYL---SPEEKEKLQK 1483

Query: 652  RMNEVISLWKKLLEATELKGIKLREANQQQ--QFNRNVEDIELWLYEVEGHLASDDYGKD 709
             M E+   ++  L  +E K +KL  + Q++  +F+ +  + E WL + E  L + + G D
Sbjct: 1484 NMKELKVHYETALAESEKK-MKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1542

Query: 710  -LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQF---------QDAGHFDAE----NI 755
             +  +    K+      DV +H+  +  ITI   +          +D G  D       +
Sbjct: 1543 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1602

Query: 756  KKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED---------EETWIRE-KEP 805
            ++K +    R+ +L          L D +   Q + D            E T  +   EP
Sbjct: 1603 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 1662

Query: 806  IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE-EGHF--AAEDVK 862
            IA       D   +Q  L++ +ALQ +I+  +  ++ + +    +++  G    A  D++
Sbjct: 1663 IAV------DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ 1716

Query: 863  AKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA-NEAESWMREKEPIVGSTDYGKD 921
              L ++  ++E L    ++R + L+ +L       D  +E   WM   E  +        
Sbjct: 1717 KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPL 1776

Query: 922  EDSA-EALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
              +A + ++ K+  L  D++   SSI A+ E+ +   +    TD  T   L   + D   
Sbjct: 1777 NSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET---TDPSTASSLQAKMKDLSA 1833

Query: 981  KSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQG 1040
            +   E + K  + L  +        KVE+ +          +KL        + L E   
Sbjct: 1834 RFS-EASHKHKETLAKMEELKT---KVELFENLS-------EKLQTFLETKTQALTE--- 1879

Query: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLE------LGEKRKGMLEKSCKKF 1094
             + +  + +   ++  +E+ S  L  K+  E+ HSLL+      L   +  +LEK+    
Sbjct: 1880 -VDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNN-- 1936

Query: 1095 MLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK------ 1148
             L ++  E++  I EK+ A+TS +    L+  +VL K    + K+       ++      
Sbjct: 1937 -LSKKFKEMEDTIKEKKEAVTSCQ--EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 1993

Query: 1149 DINKVAEDL----ESEGLMAEEVQAVQQQEVY--GMMPRDETDSKTASPWKSARLMVHTV 1202
            D+ K  ED     E   L   E+Q V    +    ++    T +K  +  KS   +++  
Sbjct: 1994 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2053

Query: 1203 ATFNSIKEL--NERWRSLQQ---------------LAEERSQLLGSAHEVQRFHRDADET 1245
             T  + +E   N+   S+++               L ++ ++L     ++Q+   ++   
Sbjct: 2054 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2113

Query: 1246 KEWIEEKNQALNTDNYGH---DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
             +W+++ N+            D  +V+    +++ FE +L    +KV  L +    L++ 
Sbjct: 2114 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEE 2173

Query: 1303 HPESAEDLQEK--CTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIR 1359
            +P++ E  + K   TE++  W  L +    R+ KL +S ++L +F +    L  W+    
Sbjct: 2174 NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE 2233

Query: 1360 GLVSS-DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQ 1418
             +VS    L+ D        ++ Q    E   R   ++     GQ +L+      P ++ 
Sbjct: 2234 LMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG-EDPSLR- 2291

Query: 1419 KLDILDQERADLEKAWVQRRMML-DQCLELQLFHRDCEQAENWMAAREAFLNTEDK--GD 1475
               I+ ++ A + + W      L D+C  +        Q ++ + +    L+  D     
Sbjct: 2292 --GIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSS 2349

Query: 1476 SL------DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAA--GHYAKGDISSRRN 1527
            SL      D++   ++  +   + I  ++++I   QA  + L A     Y K ++S +  
Sbjct: 2350 SLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLE 2409

Query: 1528 EVLDRWRRLKAQ----MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
             +L  ++ ++ +    +   +S    S   QQ SRD    +AW+  K +   +++   P 
Sbjct: 2410 GILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD---FQAWLDTKKE---EQNKSHPI 2463

Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDA-VKARLAALA 1642
            + +L  L S  + H+ F   L A +      I  G +L+ +    GSE A ++ +L  + 
Sbjct: 2464 SAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLK--TQGSEKAALQLQLNTIK 2521

Query: 1643 DQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNL 1701
              W    ++  E+  KLKE+  K   +   ++    W+ + +  L    +  D A   N 
Sbjct: 2522 TNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENS 2581

Query: 1702 LKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASR 1761
            + K + L+ ++  H   ++ LN+ A+SL++    D   V D+  ++  +   +     S+
Sbjct: 2582 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2641

Query: 1762 RAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYG-RDLTGVQNLRKKHKRLEAELAA 1820
            +  L    +  + F+++  E     +++L    E     D  G Q    K+  +      
Sbjct: 2642 KFCLENMTQKFKEFQEVSKES----KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQK 2697

Query: 1821 HEPAIQGVLDTGKKLSDDNTI------GKEEIQQRLAQFVEHWKELKQLAAARGQRLEES 1874
               A++  +D  K+L+ D  +      G  ++  ++    +    L Q    +   LE  
Sbjct: 2698 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 2757

Query: 1875 LE----YQQFVANVEEEEAWINEKMTLVA-----SEDYGDTLAAIQGLLKKHEAFETDFT 1925
            L+    +Q  +  +  + A  ++++  +A     +E        I+  LKK EA      
Sbjct: 2758 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS-- 2815

Query: 1926 VHKDRVNDVCT-------NGQDLI----------KKNNHHEENISSKMKGLNGKVSDLEK 1968
               D  N  C           DL+          K+ N   +   ++ + + G +  LE+
Sbjct: 2816 --NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE 2873

Query: 1969 AAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA 2028
              +    KL E S  LQ   KA+  E   G     ++T+   + L+  + +  K+E    
Sbjct: 2874 FYS----KLKEFSILLQ---KAEEHEESQGPV--GMETETINQQLNMFK-VFQKEEI--E 2921

Query: 2029 GLQAFQQEGIANITALKDQLL--AAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLE 2086
             LQ  QQ+    +  L   L+  AAK   ++ +E     +  RW  L    A R  +L E
Sbjct: 2922 PLQGKQQD----VNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 2977

Query: 2087 AQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDP--------VRCNSLEEIKALREAH 2138
            A  H  + +D          +  SW  + EE + +         V    ++E K L+   
Sbjct: 2978 ALLHCGRFQDAL-------ESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLL 3030

Query: 2139 DAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELEL 2198
            D  +S++   + +  ++A         ++         +  L+  W  L    + R  +L
Sbjct: 3031 DDRKSTVEVIKREGEKIATTAEPADKVKILKQ------LSLLDSRWEALLNKAETRNRQL 3084

Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
                   E    + Q+F +     ++W+      L++   +  ++  LE Q+   K    
Sbjct: 3085 -------EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3137

Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQW-DQLDQLGMRMQHNLEQQI 2317
            +I      L +   +G +++     ++K    S +  +Q W  ++ +        L+Q +
Sbjct: 3138 DIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQAL 3197

Query: 2318 QARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEF--------KSCLRSLGYDLPMVEE 2369
                  G  E  L    M + +   DK  +L+ Q++        +S LR L  D+ + ++
Sbjct: 3198 CNAKIFGEDEVEL----MNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3253

Query: 2370 GEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAF-RALSSEGKPY 2428
                     +        D  + +Q+ +  + +R  +  K S ++     +AL    + +
Sbjct: 3254 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3313

Query: 2429 VTKEEL 2434
             T EEL
Sbjct: 3314 STHEEL 3319



 Score =  167 bits (423), Expect = 1e-40
 Identities = 206/996 (20%), Positives = 441/996 (44%), Gaps = 77/996 (7%)

Query: 1    MDPSGVKVLETAE----DIQERRQQVLDRYHRFKELSTLRRQKLED--SYRFQFFQRDAE 54
            M+ +G ++LE +      IQE+       Y + KE    R   L++  S   QF  +  +
Sbjct: 3585 MNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3644

Query: 55   ELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD----------E 104
             LE    E++     E  + P ++  +++K    + ++  N    V ++          +
Sbjct: 3645 ILESL--ERIV----ERLRQPPSISAEVEK---IKEQISENKNVSVDMEKLQPLYETLKQ 3695

Query: 105  TGNLMISEG-----HFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQ------ 153
             G  MI+         +++ ++ +L ++   WE +   + E+  KLL   +L +      
Sbjct: 3696 RGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDH 3755

Query: 154  --YLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
               +   +D  D+I D E      + G D   V+  Q+  E  + ++   +E ++ V   
Sbjct: 3756 MSLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 3809

Query: 212  AAKLIQE-QHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETIS 269
             ++LI     P++ ++K   DE+N+AW  L      R  KL  A +   ++   +     
Sbjct: 3810 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 3869

Query: 270  WIKEKEQLMAS-DDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLS 328
            W+      +AS    G DL +V+  + + +  + +    + +++ L  +A+ L +     
Sbjct: 3870 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 3929

Query: 329  ATQ--IQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMKALIN 385
            + +  +Q    EL   W+ +      R  +L  +   L +F     +L +W+T  + L++
Sbjct: 3930 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 3989

Query: 386  ADE-LASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL--AAGHYASDEVREKL 442
              + +  D    E  L +H   + ++ AH+ + ++ +++G  L+  +AG  AS+ ++ KL
Sbjct: 3990 EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN-LQNKL 4048

Query: 443  TVLSEERAALLELWELRRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFLL-NEDLGDSLD 500
             VL++    +LE  E R+QQ +  +   + F+ + E +  W++  E  LL ++ LG   +
Sbjct: 4049 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4108

Query: 501  SVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAME-DVATRRDALLSRRNALH 559
            + +  L  H +   +  A+EE   +L +   +++     + E ++    + L  +  ++ 
Sbjct: 4109 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVE 4168

Query: 560  ERAMRRRAQLADSFHLQQFFRDS-DELKSWVNEKMKTATDEAYKDPSNLQG----KVQKH 614
             +   R+ +L ++ +L   F +S  +  +W+ +  +T        PS +      ++ +H
Sbjct: 4169 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN--VASRPSLILDTVLFQIDEH 4226

Query: 615  QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISL---WKKLLEATELKG 671
            + F  E+++++ +I  L+K G  L   +   K +V    N +IS+   W+K+++    +G
Sbjct: 4227 KVFANEVNSHREQIIELDKTGTHLKYFSQ--KQDVVLIKNLLISVQSRWEKVVQRLVERG 4284

Query: 672  IKLREANQQ-QQFNRNVEDIELWLYEVEGHLASD-DYGKDLTNVQNLQKKHALLEADVAA 729
              L +A ++ +QF+     +  WL E E  L S+ +   D   ++    +H   +  + A
Sbjct: 4285 RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGA 4344

Query: 730  HQDRIDGITIQARQFQDAGHFDAENIKKKQ--EALVARYEALKEPMVARKQKLADSLRLQ 787
                 D      R  ++      +N+K       L  +++ +    V R+ KL ++L   
Sbjct: 4345 KHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4404

Query: 788  QLFRD-VEDEETWIREKEP-IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
              F D ++    W+   EP +A       D+  V NL+  H+A Q E+      ++A+ +
Sbjct: 4405 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4464

Query: 846  KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAES 904
                ++E     +  VK ++ EL+ +WE + A +  ++  LE +L QA+++ +  +    
Sbjct: 4465 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4524

Query: 905  WMREKEPIVGSTD-YGKDEDSAEALLKKHEALMSDL 939
            W+ E E  +        DED+   L+ +H+  M  L
Sbjct: 4525 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL 4560



 Score =  160 bits (405), Expect = 1e-38
 Identities = 484/2522 (19%), Positives = 976/2522 (38%), Gaps = 424/2522 (16%)

Query: 9    LETAEDIQERRQQVLDRYHRFKELST-LRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIA 67
            ++  E  Q + Q+  ++    K L+T L +QK+  S   +  Q   +E +K+ ++     
Sbjct: 980  IQQVETTQRKIQE--NQPENSKTLATQLNQQKMLVS-EIEMKQSKMDECQKYAEQYSATV 1036

Query: 68   SDENYKDPTN--LQGKLQKHQAFEAEVQANSGAIV--------KLDETGNLMISEGHFAS 117
             D   +  T   +    QK       +Q+++  I+        +      LM     FA 
Sbjct: 1037 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096

Query: 118  ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLV----QYLRECEDV------MDWIND 167
            ++++     L  + + L E+ +E   K  + QK V    + L++ E           I+ 
Sbjct: 1097 DSLK----RLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS 1152

Query: 168  KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHE---------ERVNEVNQFAAKLIQE 218
            +E     E+L + L+ +++   K  +  TD   +E         E  N +   + K +QE
Sbjct: 1153 EEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1212

Query: 219  QHP------EEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIK 272
                     EE+++  +Q E     Q +  L  Q + +L G  E         E   +  
Sbjct: 1213 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1272

Query: 273  EKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQI 332
            ++E+L   D  G   A  + +      L+ +   L  + KAL  +  +L ++  +   Q+
Sbjct: 1273 KQEELQ-KDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ--KLNEAK-IKCEQL 1328

Query: 333  QVKREELITNWEQIRTLAA-ERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELAS 391
             +K E+     +++ T A  E   ++    +L+       +L  W++      N D+  S
Sbjct: 1329 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS------NVDK-DS 1381

Query: 392  DVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAA 451
            + AG +        HK  I+ +   F+  D  G++ +       DEV   L + ++    
Sbjct: 1382 ERAGTK--------HKQVIEQNGTHFQEGD--GKSAIGE----EDEVNGNL-LETDVDGQ 1426

Query: 452  LLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHED 511
            +    E   QQY++            Q +  +S+ +A ++      +  S + LL+K   
Sbjct: 1427 VGTTQENLNQQYQKVK---------AQHEKIISQHQAVII------ATQSAQVLLEKQGQ 1471

Query: 512  FEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLAD 571
            +   LS +E++         KL +N    M+++    +  L+      E+ M+    L +
Sbjct: 1472 Y---LSPEEKE---------KLQKN----MKELKVHYETALAES----EKKMKLTHSLQE 1511

Query: 572  SFHLQQFFRDSDELKSWVNEKMKTATD-EAYKDPSN-LQGKVQKHQAFEAELSANQSRID 629
               L++F  D  E + W+ +  +   + EA  D  N L  K+++ ++F  ++ +++  + 
Sbjct: 1512 E--LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1569

Query: 630  ALEKAGQKLIDVNHYAKD-------------EVAARMNEVISLWKKLLEATELKGIKLRE 676
             +  +G ++++                    EV  +++     ++ L     + G  L++
Sbjct: 1570 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1629

Query: 677  ANQQQQFNRNVE-----DIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQ 731
               + Q   +        ++        HL S+    D  N+Q   ++   L+  +++ Q
Sbjct: 1630 LVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQ 1688

Query: 732  DRIDGITIQARQFQDA--GHFDAEN-IKKKQEALVARYEALKEPMVARKQKLADSLRLQQ 788
              ++ +   A    DA      A+N I+K  + +V RYE L + +  R +KL  +L    
Sbjct: 1689 VAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 1748

Query: 789  LFRDVEDE--------ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI 840
              +D  DE        E+ ++E+  +  ++        +Q+++ K+  L+ +IAG +  I
Sbjct: 1749 SVQDGLDEMLDWMGNVESSLKEQGQVPLNST------ALQDIISKNIMLEQDIAGRQSSI 1802

Query: 841  KAVTQKGNAMVEEGH-FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA 899
             A+ +K    +E      A  ++AK+ +L+ ++     K  +    +E+     + F + 
Sbjct: 1803 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 1862

Query: 900  NEA-ESWMREKEPIVGSTDY-GKD---------EDSAEALL-KKH----EALMSDLSAYG 943
            +E  ++++  K   +   D  GKD         E ++E L  KKH     +L+ ++S++G
Sbjct: 1863 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 1922

Query: 944  -----------------------SSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQE 980
                                    +I+  +E   SC++Q+     +  + LV +L  + +
Sbjct: 1923 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL-----DAFQVLVKSLKSWIK 1977

Query: 981  KSPREVTMKKG-----DILTLLNSTNK--DWWKVEVNDRQ-----GFVPAAYVKKLD-PA 1027
            ++ ++V + +      D+   L  T K  + W ++  + Q     G      +  +  PA
Sbjct: 1978 ETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPA 2037

Query: 1028 QSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGML 1087
            ++ +    ++  G++   +    N        G  S++ K + ++ H   +LG   K  +
Sbjct: 2038 KAIAA---VKSGGAVLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI 2093

Query: 1088 EKSCKKFMLFREANE----LQQWINEKEAALTSEE---VGADLEQVEVLQKKFDDFQKDL 1140
             +   K    ++A E    + QW+ +     T  +      D E V+   ++   F+ +L
Sbjct: 2094 AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2153

Query: 1141 KANESRLKDI-NKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMV 1199
            K N ++++++ +K+ E LE                       +  D+  A  WK      
Sbjct: 2154 KQNVNKVQELKDKLTELLE-----------------------ENPDTPEAPRWKQM---- 2186

Query: 1200 HTVATFNSIKELNERWRSLQQLAEERSQLLG-SAHEVQRFHRDADETKEWIEEKN----- 1253
                    + E++ +W+ L QL  +R Q L  S++ + +F     + K+W+ EK      
Sbjct: 2187 --------LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV 2238

Query: 1254 --------QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPE 1305
                      LNT      +   +   RK + +E+  AA    ++  GE         P 
Sbjct: 2239 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQ-YEQLTAAGQGILSRPGED--------PS 2289

Query: 1306 SAEDLQEKCTELNQAWSSL----GKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGL 1361
                ++E+   + Q W SL      R D     +  S   Q  L    D +S ++    L
Sbjct: 2290 LRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN--KL 2347

Query: 1362 VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQL--LAHGHYASPEIKQK 1419
             SS  ++         LE  Q+ + EI       +  +   + L  L    Y   E+ ++
Sbjct: 2348 SSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQ 2407

Query: 1420 LDILDQERADLE-KAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDK-GDSL 1477
            L+ + +   D+E KA    + +   C     F +     + W+  ++   N        L
Sbjct: 2408 LEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKL 2467

Query: 1478 DSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYA-KGDISSRRNEVLDRWRRL 1536
            D +E+LIK H+DF K +  Q        A  + L+     + K  +  + N +   W   
Sbjct: 2468 DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF 2527

Query: 1537 KAQMIEKRSKLGES-QTLQQFSRDVDEIEAWIS------EKLQTASDESYKDPTNIQLSK 1589
              Q+ E+ +KL ES +   ++   V+ +  WI       E+++   D +  + +  +L  
Sbjct: 2528 NKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2587

Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLI--ERGACAGSEDAVKARLAALADQWQF 1647
            L  +  +H      L+  A+ +  V ++   ++  E  +     D V  +L +     + 
Sbjct: 2588 LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLEN 2647

Query: 1648 LVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDY-GKDLASVNNLLKKHQ 1706
            + QK  E  +  KE+ +Q        D       +   L S+ Y  K L  +    K  Q
Sbjct: 2648 MTQKFKEFQEVSKESKRQLQCAKEQLD-------IHDSLGSQAYSNKYLTMLQTQQKSLQ 2700

Query: 1707 LLEADISAHEDRLKDLNSQA-DSLMTSSA-FDTSQVKDKRDTINGRFQKIKSMAASRRAK 1764
             L+  +   +   +DL  +A DS  TS        +  +  T++   Q++    +    K
Sbjct: 2701 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLS---QQVDEKCSFLETK 2757

Query: 1765 L-------NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ----NLRKKHKR 1813
            L       N    +   F + DDE         L      GRD   +Q     ++   K+
Sbjct: 2758 LQGIGHFQNTIREMFSQFAEFDDE---------LDSMAPVGRDAETLQKQKETIKAFLKK 2808

Query: 1814 LEAELAAHEPAIQGVLDTGKKL--SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1871
            LEA +A+++ A +    T K +  +++ +     I++ L    +   +L   A AR +++
Sbjct: 2809 LEALMASNDNANK----TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 2864

Query: 1872 EESLE-YQQFVANVEEEEAWINEKMTLVASE-DYGDTLAAIQGLLKKHEAFE-TDFTVHK 1928
            E +++  ++F + ++E    + +      S+   G     I   L   + F+  +    +
Sbjct: 2865 EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQ 2924

Query: 1929 DRVNDVCTNGQDLIKK--NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
             +  DV   GQ LI+    +   + +   +  +N +   L K  AQR A+L E  A L  
Sbjct: 2925 GKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE--ALLHC 2982

Query: 1987 NWKADVVE---SWIGEKENSLKTD-DYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANIT 2042
                D +E   SW+ + E  +        +   V+  + +Q+     LQ    +  + + 
Sbjct: 2983 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL----LQRLLDDRKSTVE 3038

Query: 2043 ALK---DQLLAAKHVQSKAIEARHASLM-KRWSQLLANSAARKKKL----LEAQSHFRKV 2094
             +K   +++        K    +  SL+  RW  LL  +  R ++L    + AQ     +
Sbjct: 3039 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3098

Query: 2095 EDL--FLTFAKKA---------------------SAFNSWFENAEEDLTDPVRCNSLEEI 2131
            E L  +LT  +K                       A      N  + L   V      ++
Sbjct: 3099 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3158

Query: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
             + RE  D  +S L     DF+Q+  ++ Q KS             E L++   N  KI 
Sbjct: 3159 LSSREDKDMVQSKL-----DFSQVWYIEIQEKSHS---------RSELLQQALCN-AKIF 3203

Query: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGT------ 2245
             E E+EL       E +DKL +   Q  +    W Q++   +L    ++ +         
Sbjct: 3204 GEDEVELM--NWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3261

Query: 2246 ---------------LESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEH 2290
                           ++ +LEA K ++++I  + +      D+   +E+AL L  +   H
Sbjct: 3262 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLST------DVAKTLEQALQLARRL--H 3313

Query: 2291 ST 2292
            ST
Sbjct: 3314 ST 3315



 Score =  112 bits (281), Expect = 3e-24
 Identities = 330/1819 (18%), Positives = 696/1819 (38%), Gaps = 265/1819 (14%)

Query: 669  LKGIKLREANQQQQFNRN-VEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADV 727
            LK   L +   +++ N   V+D+  W+ E++  L   ++G DL +V++  + H  +   +
Sbjct: 263  LKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 322

Query: 728  AAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQ 787
               +  +    I   Q             +K   L ++Y  L      +++ L     L 
Sbjct: 323  EEFESSLKEAKISEIQMTAPLKL---TYAEKLHRLESQYAKLLNTSRNQERHLDT---LH 376

Query: 788  QLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKG 847
                   +E  W+ EKE    + +  +    +      H  L  E+   E  IK+V +  
Sbjct: 377  NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIA 436

Query: 848  NAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMR 907
              ++ E H A   ++A    +  +W  +        Q ++++    ++F DA EA  ++R
Sbjct: 437  EQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR 496

Query: 908  EKEPIVG---STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTD 964
              +  +    S D        E L+++      +L  Y S+I  L  +A++  Q      
Sbjct: 497  NLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 556

Query: 965  DETGKEL--VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKV-EVNDRQGFVPAAYV 1021
            D   K    + A+ DY++    E+T+ K D   L N++++  WKV      +  VP+   
Sbjct: 557  DCPLKTSIPIKAICDYRQ---IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCF 613

Query: 1022 KKLDPAQSA-SRENLLEE--QGSIALRQEQIDNQTRIT------------KEAGSVSLRM 1066
                P + A    N +E+  Q  + L  E   N   +             + +   S++ 
Sbjct: 614  TVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKT 673

Query: 1067 KQVEELYHSLLELGEKRKGMLEKSCKK--------FMLFREANELQQWINEKEAALTSEE 1118
                E    L  L  + +  LE S +           L +E N  +Q+  E   +   EE
Sbjct: 674  MLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREE 733

Query: 1119 ------------------------------VGADLEQVEVLQKKFD-DFQKDLKANESRL 1147
                                          +   LE+ ++ +  F    Q+ LK    RL
Sbjct: 734  QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERL 793

Query: 1148 KD----INKVAEDLESEGLMAEEVQAVQQQ---------EVYGM----MPRDETDSKTAS 1190
            KD    I    E+  S+   +  V  ++ +         +VY M    + + +T +    
Sbjct: 794  KDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLK 853

Query: 1191 PWKSARLMVH-----------TVATFNSIKEL---NERWRS--------LQQLAEERSQL 1228
              ++A  +V             +A  N+I+ L    ++WRS           L +E  + 
Sbjct: 854  NTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913

Query: 1229 LGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDK 1288
               + E+ + +++ D   +W +EK   L  + + +    +    R  EG  + L    D 
Sbjct: 914  KAISDEMFKTYKERDLDFDWHKEKADQL-VERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 972

Query: 1289 VNSLG------ETAERLIQ-SHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD- 1340
             + L       ET +R IQ + PE+++ L    T+LNQ    L    + +++K+ +    
Sbjct: 973  YHPLDDWIQQVETTQRKIQENQPENSKTL---ATQLNQQ-KMLVSEIEMKQSKMDECQKY 1028

Query: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELA-----KDVTGAEALLERHQEHRTEIDARAGTF 1395
             +++ +  +D        R +V S + +     +  + A+ +++   + RT   A     
Sbjct: 1029 AEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLM 1088

Query: 1396 QAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLF----- 1450
              + +F          A   +K+    L++E   LE+   +++  +++  ELQ +     
Sbjct: 1089 TQYIKF----------AGDSLKR----LEEEEKSLEE---EKKEHVEKAKELQKWVSNIS 1131

Query: 1451 --HRDCEQA------ENWMAAREAFLNTEDKGDSLDSVEALIKKHED--FDKAINVQEEK 1500
               +D E+A      +  +++ E     E   ++L +++  + KH D   D+  N  E++
Sbjct: 1132 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1191

Query: 1501 IAALQAFADQLIAAG------HYAKGDISSRRNEVLDRWRRLKAQ-------MIEKRSKL 1547
            +  LQ   + L +            GD+      V +R +  K +       + +  ++L
Sbjct: 1192 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1251

Query: 1548 GESQTLQQFSRDVDEIEAWISEKLQTASD---------ESYKDPTNI---------QLSK 1589
               Q          E++ + S++ +   D         E  K+  N          Q  K
Sbjct: 1252 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1311

Query: 1590 LLSKHQKHQAFE--AELHANADRIRGVIDMG-----NSLIERGACAGSEDAVKARLAALA 1642
             L + + ++A     +L+  A++ +  +D           E+ A     +  K ++  L 
Sbjct: 1312 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1371

Query: 1643 DQWQFLVQKSAEKS-QKLKEANKQQNFNTGIKDFDFWLSEVEA----LLASEDYGKDLAS 1697
            D W   V K +E++  K K+  +Q   +    D    + E +     LL ++  G+   +
Sbjct: 1372 D-WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1430

Query: 1698 VNNLLKKHQLLEAD----ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
              NL +++Q ++A     IS H+  +    S    L     + + + K+K    N +  K
Sbjct: 1431 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK-NMKELK 1489

Query: 1754 IKSMAA----SRRAKLNES--HRLHQFFRDMDDEESWIKEKKLLVGSEDYGR-DLTGVQN 1806
            +    A     ++ KL  S    L +F  D  + E W+++ +  + + + G  D+ G+  
Sbjct: 1490 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 1549

Query: 1807 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSD-------------DNTIGKEEIQQRLAQF 1853
              K+ K    ++ +H+  ++ +  +G ++ +             D +    E+Q++L   
Sbjct: 1550 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 1609

Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQF-------VANVEEEEAWINEKMTLVASEDYGD 1905
             + ++ L       G  L++ ++ YQ +       +A ++  EA  ++ +    SE    
Sbjct: 1610 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL----SEPIAV 1665

Query: 1906 TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNH---HEENISSKMKGLNGK 1962
                +Q  L++ +A +   +  +  V  +    + L+         + +I   +  + G+
Sbjct: 1666 DPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGR 1725

Query: 1963 VSDLEKAAAQRKAKLDEN-SAFLQFNWKADVVESWIGEKENSLKTD-DYGRDLSSVQTLL 2020
              DL K+  +R  KL    +  L      D +  W+G  E+SLK       + +++Q ++
Sbjct: 1726 YEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDII 1785

Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
            +K    +  +   Q    ++I A+ +++         +  +   + MK  S   + ++ +
Sbjct: 1786 SKNIMLEQDIAGRQ----SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK 1841

Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
             K+ L      +   +LF   ++K   F      A  ++  P +     ++  L +    
Sbjct: 1842 HKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGK-----DVTELSQYMQE 1896

Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQK 2200
              S     +     L  L ++I S  + S+         LE+T  NL K  KE E  +++
Sbjct: 1897 STSEFLEHKKHLEVLHSLLKEISSHGLPSDKAL-----VLEKT-NNLSKKFKEMEDTIKE 1950

Query: 2201 EQRRQEENDKLRQEFAQHANAFHQWIQET--RTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
            ++       +    F     +   WI+ET  +  ++  S   E+ G     LE TK+  +
Sbjct: 1951 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLEDTKKLQE 2007

Query: 2259 EIRAMRSQLKKIEDLGAAM 2277
            +      +++K+ + G ++
Sbjct: 2008 KWSLKTPEIQKVNNSGISL 2026



 Score =  102 bits (255), Expect = 4e-21
 Identities = 450/2452 (18%), Positives = 904/2452 (36%), Gaps = 352/2452 (14%)

Query: 30   KELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQ--IASDENYKDPTNLQGKLQKHQA 87
            K L+T R Q+        F  R   EL  W+ EK +  +A D + ++ TN+  K   H  
Sbjct: 360  KLLNTSRNQERHLDTLHNFVSRATNELI-WLNEKEEEEVAYDWSERN-TNIARKKDYHAE 417

Query: 88   FEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQ 147
               E+      I  + E    ++ E H A  TI      +  QW  +L+           
Sbjct: 418  LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ----------L 467

Query: 148  AQKLVQYLRECEDVMDWIND-KEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVN 206
             Q + Q+++E     ++ ND KEA      L       + +Q+K+           +R +
Sbjct: 468  CQCVEQHIKENTAYFEFFNDAKEATDYLRNL------KDAIQRKYS---------CDRSS 512

Query: 207  EVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGK---LFGAAEVQRF--N 261
             +++    + +    +EEL++ K    N   +    + L+ +     L  +  ++     
Sbjct: 513  SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDY 572

Query: 262  RDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRL 321
            R ++ TI   K+ E ++A++        +                 E  V ++C      
Sbjct: 573  RQIEITI--YKDDECVLANNSHRAKWKVISP------------TGNEAMVPSVCFTVPPP 618

Query: 322  QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF-RDLTSWVTEM 380
             +     A +I+ + + ++T W        E H  +         + +  R   S V  +
Sbjct: 619  NKEAVDLANRIEQQYQNVLTLWH-------ESHINMKSVVSWHYLINEIDRIRASNVASI 671

Query: 381  KALINADE---LASDVAGAEALLDRHQEHK----GEIDAHEDSFKSADESGQALLAAGHY 433
            K ++  +    L++  +  E  L+  QE +     +I   E       +  Q LL +   
Sbjct: 672  KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 731

Query: 434  ASDEVREKLTVLSEERAALLELWELRRQQYEQCM------DL-QLFYRDTEQVDNWMSKQ 486
               E       +SE R   L L     +   Q        DL +  +R TEQ      K+
Sbjct: 732  EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQE---KLKK 788

Query: 487  EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
            E   L +DLG        +  K E+F  S +A    +  L      ++QN +      +T
Sbjct: 789  ELERLKDDLG-------TITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840

Query: 547  RRDAL----LSRRNALHERAM---------RRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
              D L    L  +N     A+            A +AD  +++       + +S V+EK 
Sbjct: 841  YIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 900

Query: 594  K---TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKL-IDVNHYAKD-- 647
            +      DE  K  +      + ++  + +   ++ + D L +  Q + + +++  +D  
Sbjct: 901  QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLE 960

Query: 648  ------EVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHL 701
                  +        +  W + +E T+ K I+  +    +     +   ++ + E+E   
Sbjct: 961  GIGKSLKYYRDTYHPLDDWIQQVETTQRK-IQENQPENSKTLATQLNQQKMLVSEIEMKQ 1019

Query: 702  AS-DDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQE 760
            +  D+  K         K + L      A  D      ++ R+ Q +    A+ I ++  
Sbjct: 1020 SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS----ADLIIQEFM 1075

Query: 761  ALVARYEALKEPMVARKQKLADSL-RLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGV 819
             L  RY AL   M    +   DSL RL++  + +E+E     +KE +  +    K +  +
Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEE-----KKEHVEKAKELQKWVSNI 1130

Query: 820  QNLLKKHQALQAEIAGHEP--RIKAVTQKGNAMVEEGHFAAEDVKAKL------------ 865
               LK      AE AG  P  + K  +++ +   E+   A + ++  L            
Sbjct: 1131 SKTLK-----DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEER 1185

Query: 866  HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE-----KEPIVGSTDYGK 920
            +EL ++ + L+   +    +    LQ  Q   D    E  + E     KE + G  D   
Sbjct: 1186 NELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLT 1245

Query: 921  DEDSAEALLKKHEALM-----SDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLAL 975
              ++   L+   EA M      +L  Y S  + L++  Q   Q +A    E  K     L
Sbjct: 1246 QTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA----EVVKNTENFL 1299

Query: 976  YDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENL 1035
             +  EK  +E    K  I   LN       ++ +   Q        K+LD   + +   +
Sbjct: 1300 KENGEKLSQE---DKALIEQKLNEAKIKCEQLNLKAEQS------KKELDKVVTTA---I 1347

Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
             EE   +A  ++  +++T+I      +S   K  E         G K K ++E++   F 
Sbjct: 1348 KEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE-------RAGTKHKQVIEQNGTHF- 1399

Query: 1096 LFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLK-DINKVA 1154
                     Q  + K A    +EV  +L + +V   +    Q++L     ++K    K+ 
Sbjct: 1400 ---------QEGDGKSAIGEEDEVNGNLLETDV-DGQVGTTQENLNQQYQKVKAQHEKII 1449

Query: 1155 EDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNER 1214
               ++  +  +  Q + +++   + P ++   +                   ++KEL   
Sbjct: 1450 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ------------------KNMKELKVH 1491

Query: 1215 WRSLQQLAEERSQLLGS-AHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQ 1272
            + +    +E++ +L  S   E+++F  D  E + W+++  Q L N +    D+  +    
Sbjct: 1492 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1551

Query: 1273 RKHEGFERDLAALGDKVNSLGETAERLIQSHPESAE-------------DLQEKCTELNQ 1319
            ++ + F  D+ +    +  +  +  R++++    ++             ++Q K      
Sbjct: 1552 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1611

Query: 1320 AWSSLGKRADQRKAKLGDSHDLQRFLSDFR-DLMSWINGIRGLVS---SDELAKDVTGAE 1375
             + SL  + +     L D  D  +   D    L++ +       S   S+ +A D    +
Sbjct: 1612 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 1671

Query: 1376 ALLERHQEHRTEIDARAGTFQAFEQFGQQLL-AHGHY--ASPEIKQKLDILDQERADLEK 1432
              LE  +  + +I ++    +  ++  + LL A G    A  +I++ LD +     DL K
Sbjct: 1672 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 1731

Query: 1433 AWVQRRMMLDQCLELQLFHRD-CEQAENWMAAREAFLNTE-----DKGDSLDSVEALIKK 1486
            +  +R   L   L   L  +D  ++  +WM   E+ L  +     +     D +   I  
Sbjct: 1732 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 1791

Query: 1487 HEDF---DKAINVQEEKIAALQAFADQLIAAGHYAK-GDISSRRNEVLDRWRRLKAQMIE 1542
             +D      +IN   EK+       D   A+   AK  D+S+R +E   + +   A+M E
Sbjct: 1792 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 1851

Query: 1543 KRSKLGESQTLQQFSRDVDEIEAWISEKLQ--TASDESYKDPTNIQ--LSKLLSKHQKHQ 1598
             ++K      ++ F    ++++ ++  K Q  T  D   KD T +   + +  S+  +H+
Sbjct: 1852 LKTK------VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 1905

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
                 LH+               I        +  V  +   L+ +++ +     EK + 
Sbjct: 1906 KHLEVLHSLLKE-----------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 1954

Query: 1659 LKEANKQQN-FNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLLKKHQLLEA 1710
            +    +Q + F   +K    W+ E       V+    +ED GK L     L +K  L   
Sbjct: 1955 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2014

Query: 1711 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTING--------RFQKIKSMAASRR 1762
            +I    +    L     S +T+ A   + VK     +NG         F   K + + ++
Sbjct: 2015 EIQKVNNSGISL-CNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2073

Query: 1763 AKLNESHRLHQFFRDMDDEESWIKEK--KLLVGSEDYGRDLTGVQNLRK----------- 1809
               + SH        + D+ + +  K  KL    E+    +  +Q + K           
Sbjct: 2074 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2133

Query: 1810 -----------KHKRLEAELAAHEPAIQGVLDTGKKLSDDN--TIGKEEIQQRLAQFVEH 1856
                       ++K  EAEL  +   +Q + D   +L ++N  T      +Q L +    
Sbjct: 2134 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2193

Query: 1857 WKELKQLAAARGQRLEESL-EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLL- 1914
            W+EL QL   R Q+LEES     QF     + + W+ EK  +V+       L+    +L 
Sbjct: 2194 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS---VLGPLSIDPNMLN 2250

Query: 1915 ---KKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEE----------NISSKMKGLNG 1961
               ++ +    +F   K +   +   GQ ++ +                 ++ K   L G
Sbjct: 2251 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2310

Query: 1962 KVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLT 2021
            ++SD      Q   K  +  + L               +  S K  D    LSS   + T
Sbjct: 2311 QLSDRCDWIDQAIVKSTQYQSLL---------------RSLSDKLSDLDNKLSSSLAVST 2355

Query: 2022 KQETFDAGLQAFQQEGIANITALKDQLLAAKHV---QSKAIEARH--ASLMKRWSQLLAN 2076
              +  +  L+  Q+     I   K Q+  A+ +    S  ++  +  A L ++   +L +
Sbjct: 2356 HPDAMNQQLETAQKMK-QEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2414

Query: 2077 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE--NAEEDLTDPVRCNSLEEIKAL 2134
                ++K      H +        F + +  F +W +    E++ + P+    L+ +++L
Sbjct: 2415 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISA-KLDVLESL 2473

Query: 2135 REAHDAFRSSLSSAQADFNQ-LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
             + H  F  +L++    + + +AE +  +   + +        +  ++  W    K +KE
Sbjct: 2474 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2533

Query: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLD-GSCMVEESGTLESQLEA 2252
            RE +L       +E+ +   ++ +       WI + +  L +   C+    G  E+ +  
Sbjct: 2534 RENKL-------KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG--ENSIAK 2584

Query: 2253 TKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQ 2304
             K   +E+      ++ + +   ++     +D +        L Q+ D + +
Sbjct: 2585 LKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTE 2636



 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 87/439 (19%), Positives = 179/439 (40%), Gaps = 52/439 (11%)

Query: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIASDENY 72
            + +   ++ D++      S  R+ KLE++  F     DA + L  W+   + Q+A D+  
Sbjct: 4372 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4431

Query: 73   KDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
                +L    +  H+AF+ E+   + ++  L  +   +I      S  ++ ++ EL  +W
Sbjct: 4432 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4491

Query: 132  ELLLEKMREKGIKLLQAQKLVQYLRECED-------VMDWINDKEAIVTSEE-LGQDLEH 183
            E +        + + +  +L   LR+ E+       +++W+ + E  +     L  D + 
Sbjct: 4492 ETVC------ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4545

Query: 184  VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEE-ELIKTKQDEVNAAWQRLKG 242
            +  L  + +EF   +      +N+       ++   HP+    IK     + A ++ +  
Sbjct: 4546 LRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLA 4605

Query: 243  LALQRQGKLFGAAEVQRFNRDVDETI-SWIKEKEQLMASDD---FGRDLASVQALLRKHE 298
             A Q Q +L  A       +++ E + +W++  E  +   D     +++  V+AL+ +H+
Sbjct: 4606 WAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQ 4665

Query: 299  GLERDLAALE---DKV----KALCAEADRLQQSHPL--------------------SATQ 331
                ++   +   DKV    K   A+   LQ   P+                    S TQ
Sbjct: 4666 TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQ 4725

Query: 332  IQVKREE---LITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADE 388
            I+ K      L++ W+Q+  LA ER  +LND+      L +F +    +   K +   + 
Sbjct: 4726 IETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNH 4785

Query: 389  LASDVAGAEALLDRHQEHK 407
              S V      +D+ Q+ K
Sbjct: 4786 KKSRVMDFFRRIDKDQDGK 4804



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 64/276 (23%), Positives = 114/276 (41%), Gaps = 12/276 (4%)

Query: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
           +DL +WV EM+  ++  E  SD+   E+ L+ H+     I+  E S K A  S   + A 
Sbjct: 283 QDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP 342

Query: 431 GHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFL 490
                    EKL  L  + A LL      R Q      L  F         W++++E   
Sbjct: 343 ---LKLTYAEKLHRLESQYAKLL---NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 396

Query: 491 LNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDA 550
           +  D  +   ++      H +  + L  +EE I ++ E A +L+  NH A   +   R A
Sbjct: 397 VAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAA 456

Query: 551 LLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYK-DPSN--- 606
           + ++ + + +        + ++    +FF D+ E   ++   +K A    Y  D S+   
Sbjct: 457 MQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL-RNLKDAIQRKYSCDRSSSIH 515

Query: 607 -LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDV 641
            L+  VQ+    + EL   +S I  L    + +I +
Sbjct: 516 KLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 551



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 63/279 (22%), Positives = 118/279 (42%), Gaps = 22/279 (7%)

Query: 145 LLQAQKLVQYLRECE-------DVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTD 197
           LL++  L Q L E E       D+++W+++ +  +   E G DL  VE      E  +  
Sbjct: 262 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVE---SHLENHKNV 318

Query: 198 MAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEV 257
             A EE  + + +     IQ   P +     K   + + + +L   +  ++  L     +
Sbjct: 319 HRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTL 375

Query: 258 QRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAE 317
             F       + W+ EKE+   + D+     ++      H  L R+L   E+ +K++   
Sbjct: 376 HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEI 435

Query: 318 ADR-LQQSHPLSATQIQVKREELITNWEQIRTL--AAERHARLNDSYRLQRFLADFRDLT 374
           A++ L ++HP   T I+  R  + T W  I  L    E+H + N +Y    F  D ++ T
Sbjct: 436 AEQLLLENHPARLT-IEAYRAAMQTQWSWILQLCQCVEQHIKENTAY--FEFFNDAKEAT 492

Query: 375 SWVTEMKALIN---ADELASDVAGAEALLDRHQEHKGEI 410
            ++  +K  I    + + +S +   E L+    E K E+
Sbjct: 493 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531


>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
          Length = 887

 Score =  277 bits (708), Expect = 1e-73
 Identities = 159/501 (31%), Positives = 280/501 (55%), Gaps = 26/501 (5%)

Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
            +F  KA + E+W   KE  L+  DY    LS ++ LL K E F++ L A  Q+ +  I A
Sbjct: 398  KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAA-HQDRVEQIAA 456

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            +  +L    +  S ++ AR   +  +W  L A +  R++ L   +     ++ L+L +AK
Sbjct: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516

Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLA------E 2157
            +A+ FN+W E A EDL D    +++EEI+ L  AH+ F+++L    AD  +LA      E
Sbjct: 517  RAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATL--PDADKERLAILGIHNE 574

Query: 2158 LDRQIKSFRV---ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQE 2214
            + + ++++ V    +NPYT  T + +   W ++++++  R+  L +E  RQ+ N++LR++
Sbjct: 575  VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634

Query: 2215 FAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLG 2274
            F   AN    WIQ     +  G   +E  GTLE QL   ++  + I   + ++ ++E   
Sbjct: 635  FGAQANVIGPWIQTKMEEI--GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692

Query: 2275 AAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFS 2334
              ++EALI DNK+T ++   +   W+QL     R  + +E QI  R+  G+++E + EF 
Sbjct: 693  QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR 752

Query: 2335 MMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQ 2394
              F HFD+ K+G ++  +F++CL S+GY++        + EF  I+  VDPNR G V+ Q
Sbjct: 753  ASFNHFDRKKTGMMDTDDFRACLISMGYNM-------GEAEFARIMSIVDPNRLGVVTFQ 805

Query: 2395 EYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYV 2454
             ++ FM SRET +  +++++ ++F+ L+ + K Y+T +EL + L  +QA+YC++ M PY 
Sbjct: 806  AFIDFM-SRETADTDTADQVMASFKILAGD-KNYITMDELRRELPPDQAEYCIARMAPYT 863

Query: 2455 DGKGRELPTAFDYVEFTRSLF 2475
                  +P A DY+ F+ +L+
Sbjct: 864  GPD--SVPGALDYMSFSTALY 882



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 83/382 (21%), Positives = 162/382 (42%), Gaps = 47/382 (12%)

Query: 1867 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFT 1925
            R +RL+   E  +F       EAW + K  ++  +DY   TL+ I+ LLKKHEAFE+D  
Sbjct: 388  RLERLDHLAE--KFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445

Query: 1926 VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE 1979
             H+DRV  +    Q+L + + +   +++++ + +       G ++   + A +R  KL E
Sbjct: 446  AHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLE 505

Query: 1980 --NSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
              +  +L++  +A    +W+      L+       +  +Q L T  E F A L    +E 
Sbjct: 506  TIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKER 565

Query: 2038 IANITALKDQLLAAKHVQSKAIEARHASLM--------------KRWSQLLANSAARKKK 2083
            +A        +L   +  SK ++  H ++                +W  +      R + 
Sbjct: 566  LA--------ILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQA 617

Query: 2084 LLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDA 2140
            L E  +  +  E L   F  +A+    W +   E+   ++  +     +++  LR+    
Sbjct: 618  LTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ---- 673

Query: 2141 FRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL----QKIIKEREL 2196
            +  S+ + +   +QL    + I+   +  N +T +TME +   W  L     + I E E 
Sbjct: 674  YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 733

Query: 2197 ELQKEQRR---QEENDKLRQEF 2215
            ++     +   QE+ ++ R  F
Sbjct: 734  QILTRDAKGISQEQMNEFRASF 755



 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 50/250 (20%), Positives = 110/250 (44%), Gaps = 14/250 (5%)

Query: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
            ++R   LD   E   F +     E W   +EA L  +D +  +L  ++AL+KKHE F+  
Sbjct: 386  IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443

Query: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKA------QMIEKRSKL 1547
            +   ++++  + A A +L    +Y    +++R  ++ D+W  L A      + +E+  KL
Sbjct: 444  LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503

Query: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
             E+  Q   ++++       W+   ++   D ++   T  ++  L + H++ +A   +  
Sbjct: 504  LETIDQLYLEYAKRAAPFNNWMEGAMEDLQD-TFIVHTIEEIQGLTTAHEQFKATLPDAD 562

Query: 1606 ANADRIRGVIDMGNSLIE--RGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
                 I G+ +  + +++      AG+          +  +W  + Q    + Q L E +
Sbjct: 563  KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622

Query: 1664 KQQNFNTGIK 1673
             +Q  N  ++
Sbjct: 623  ARQQHNERLR 632



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 36/137 (26%), Positives = 63/137 (45%), Gaps = 9/137 (6%)

Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
            + ++N  W  L+Q        L  E  +L    H  ++F + A   + W + K   L   
Sbjct: 361  VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK 420

Query: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
            +Y    L+ ++AL +KHE FE DLAA  D+V  +   A+ L +     +  +  +C ++ 
Sbjct: 421  DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC 480

Query: 1319 QAWSSLGKRADQRKAKL 1335
              W +LG    +R+  L
Sbjct: 481  DQWDNLGALTQKRREAL 497



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 72/348 (20%), Positives = 142/348 (40%), Gaps = 49/348 (14%)

Query: 357 LNDSYRLQRF--LAD-FRDLTS----WVTEMKALINA-DELASDVAGAEALLDRHQEHKG 408
           LN+  RL+R   LA+ FR   S    W    +A++   D   + ++  +ALL +H+  + 
Sbjct: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFES 442

Query: 409 EIDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMD 468
           ++ AH+D  +      Q L    +Y S  V  +   + ++   L  L + RR+  E+   
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502

Query: 469 L-----QLFYRDTEQV---DNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSL-SAQ 519
           L     QL+    ++    +NWM      L +  +  +++ ++ L   HE F+ +L  A 
Sbjct: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDAD 562

Query: 520 EEK--ITALDEFATKLIQNNHYAM---------------------EDVATRRDALLSRRN 556
           +E+  I  +    +K++Q  H  M                       +  RRD  L+  +
Sbjct: 563 KERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEH 622

Query: 557 ALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQA 616
           A  +   R R         +QF   ++ +  W+  KM+     + +    L+ ++   + 
Sbjct: 623 ARQQHNERLR---------KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQ 673

Query: 617 FEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
           +E  +   + +ID LE   Q + +   +        M  +   W++LL
Sbjct: 674 YEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLL 721



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 84/389 (21%), Positives = 154/389 (39%), Gaps = 44/389 (11%)

Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
            Q++E   KL  S  L+   R +  +E  + E    A  +  +D  +    + L K  K Q
Sbjct: 274  QLMEDYEKLA-SDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDY---RRLHKPPKVQ 329

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657
              + +L  N + ++  + + N    R A   SE  +   ++ + + W  L Q +   +  
Sbjct: 330  E-KCQLEINFNTLQTKLRLSN----RPAFMPSEGRM---VSDINNAWGCLEQVEKGYEEW 381

Query: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLE 1709
             L E  + +  +   + F       + W    EA+L  +DY    L+ +  LLKKH+  E
Sbjct: 382  LLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441

Query: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769
            +D++AH+DR++ + + A  L     +D+  V  +   I  ++  + ++   RR  L  + 
Sbjct: 442  SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501

Query: 1770 RLHQFFRDMDDE--------ESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAH 1821
            +L +    +  E         +W++     +        +  +Q L   H++ +A L   
Sbjct: 502  KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561

Query: 1822 EP---AIQGVLDTGKKLSDD---NTIGKEEIQQRLAQFVE-HWKELKQLAAARGQRLEES 1874
            +    AI G+ +   K+      N  G         Q +   W  ++QL   R Q L E 
Sbjct: 562  DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621

Query: 1875 LEYQ--------QFVANVEEEEAWINEKM 1895
               Q        QF A       WI  KM
Sbjct: 622  HARQQHNERLRKQFGAQANVIGPWIQTKM 650



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 53/235 (22%), Positives = 102/235 (43%), Gaps = 25/235 (10%)

Query: 149 QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVNE 207
           Q +  Y +   D+++WI  +        + ++  H   +Q+K E+F+     H+  +V E
Sbjct: 274 QLMEDYEKLASDLLEWIR-RTIPWLENRVPENTMHA--MQQKLEDFRDYRRLHKPPKVQE 330

Query: 208 -------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRLKGLA----------LQRQG 249
                   N    KL     P     + +   ++N AW  L+ +           ++R  
Sbjct: 331 KCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLE 390

Query: 250 KLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAALE 308
           +L   AE  R    + E  +W   KE ++   D+    L+ ++ALL+KHE  E DLAA +
Sbjct: 391 RLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQ 448

Query: 309 DKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
           D+V+ + A A  L +     +  +  + +++   W+ +  L  +R   L  + +L
Sbjct: 449 DRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 68/347 (19%), Positives = 143/347 (41%), Gaps = 31/347 (8%)

Query: 32  LSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDPT--NLQGKLQKHQAFE 89
           L+ +RR +  D    +F Q+ A   E W   K  +   ++Y+  T   ++  L+KH+AFE
Sbjct: 383 LNEIRRLERLDHLAEKFRQK-ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE 441

Query: 90  AEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE---LLLEKMR---EKGI 143
           +++ A+   + ++      +    ++ S ++  R  ++  QW+    L +K R   E+  
Sbjct: 442 SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTE 501

Query: 144 KLLQA--QKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMA-A 200
           KLL+   Q  ++Y +      +W+      +    +   +E ++ L    E+F+  +  A
Sbjct: 502 KLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDA 561

Query: 201 HEER--VNEVNQFAAKLIQEQHPE----EELIKTKQDEVNAAWQRLKGLALQRQGKLFGA 254
            +ER  +  ++   +K++Q  H               E+N  W  ++ L  +R   L   
Sbjct: 562 DKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEE 621

Query: 255 AEVQRFNRDVDETIS--------WIKEKEQLMA--SDDFGRDLASVQALLRKHEGLERDL 304
              Q+ N  + +           WI+ K + +   S +    L    + LR++   E+ +
Sbjct: 622 HARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQY---EKSI 678

Query: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
              + K+  L  +   +Q++            E +   WEQ+ T  A
Sbjct: 679 VNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA 725



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 57/286 (19%), Positives = 118/286 (41%), Gaps = 31/286 (10%)

Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
           ++F +     E W    E  L   DY    L+ ++ L KKH   E+D+AAHQDR++ I  
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456

Query: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQLFRDV 793
            A++  +  ++D+ ++  + + +  +++ L      +   + R +KL ++  + QL+ + 
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLET--IDQLYLEY 514

Query: 794 EDE----ETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPR---IKAVTQK 846
                    W+         T     +  +Q L   H+  +A +   +     I  +  +
Sbjct: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNE 574

Query: 847 GNAMVEEGHFAAEDVKAKL----HELNQKWEALKAKASQRRQDLEDSLQAQ--------Q 894
            + +V+  H               E+N KW+ ++    +R Q L +    Q        Q
Sbjct: 575 VSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQ 634

Query: 895 YFADANEAESWMREKEPIVGSTD---YGKDEDSAEALLKKHEALMS 937
           + A AN    W++ K   +G      +G  ED    L +  +++++
Sbjct: 635 FGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVN 680



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 65/317 (20%), Positives = 127/317 (40%), Gaps = 34/317 (10%)

Query: 482 WMSKQEAFLLNEDLGDS-LDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 540
           W   +EA L  +D   + L  ++ALLKKHE FE  L+A ++++  +   A +L + ++Y 
Sbjct: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468

Query: 541 MEDVATRRDALLSRRNALHERAMRRRAQL---------ADSFHLQQFFRDSDELKSWVNE 591
              V  R   +  + + L     +RR  L          D  +L ++ + +    +W+  
Sbjct: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYL-EYAKRAAPFNNWMEG 527

Query: 592 KMKTATDE-AYKDPSNLQGKVQKHQAFEAEL-SANQSRIDAL--EKAGQKLIDVNHY--- 644
            M+   D         +QG    H+ F+A L  A++ R+  L       K++   H    
Sbjct: 528 AMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA 587

Query: 645 -AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVED--------IELWL- 694
                      E+   W  + +    +   L E + +QQ N  +          I  W+ 
Sbjct: 588 GTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQ 647

Query: 695 --YEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDA 752
              E  G ++ + +G     + +L++     E  +  ++ +ID +    +  Q+A  FD 
Sbjct: 648 TKMEEIGRISIEMHGTLEDQLSHLRQ----YEKSIVNYKPKIDQLEGDHQLIQEALIFDN 703

Query: 753 ENIKKKQEALVARYEAL 769
           ++     E +   +E L
Sbjct: 704 KHTNYTMEHIRVGWEQL 720



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 65/326 (19%), Positives = 136/326 (41%), Gaps = 54/326 (16%)

Query: 1034 NLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093
            N L+ +  ++ R   + ++ R+  +  +    ++QVE+ Y   L    +R   L+   +K
Sbjct: 339  NTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398

Query: 1094 FMLFREANELQQWINEKEAALTSEEVG-ADLEQVEVLQKKFDDFQKDLKANESRLKDINK 1152
            F   ++A+  + W + KEA L  ++   A L +++ L KK + F+ DL A++ R++ I  
Sbjct: 399  FR--QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456

Query: 1153 VAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELN 1212
            +A++L              + + Y             SP  +AR            +++ 
Sbjct: 457  IAQELN-------------ELDYYD------------SPSVNARC-----------QKIC 480

Query: 1213 ERWRSLQQLAEERSQLLGSAHEVQR--------FHRDADETKEWIEEKNQALNTDNYGHD 1264
            ++W +L  L ++R + L    ++          + + A     W+E   + L      H 
Sbjct: 481  DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT 540

Query: 1265 LASVQALQRKHEGFERDLA-ALGDKVNSLG--ETAERLIQSHPESAEDLQEKCT----EL 1317
            +  +Q L   HE F+  L  A  +++  LG      +++Q++  +        T    E+
Sbjct: 541  IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI 600

Query: 1318 NQAWSSLGKRADQRKAKLGDSHDLQR 1343
            N  W  + +   +R   L + H  Q+
Sbjct: 601  NGKWDHVRQLVPRRDQALTEEHARQQ 626



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 9/121 (7%)

Query: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621
           RR +  D  HL + FR    + ++W + K      + Y+    S ++  ++KH+AFE++L
Sbjct: 387 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444

Query: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
           +A+Q R++ +    Q+L ++++Y    V AR  ++   W  L   T+    K REA ++ 
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ----KRREALERT 500

Query: 682 Q 682
           +
Sbjct: 501 E 501



 Score = 48.5 bits (114), Expect = 8e-05
 Identities = 27/114 (23%), Positives = 59/114 (51%), Gaps = 8/114 (7%)

Query: 776 RKQKLADSLRLQQLFRDV--EDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEI 833
           R   LA+  R +    +   + +E  +R+K+   A+ +       ++ LLKKH+A ++++
Sbjct: 391 RLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSE------IKALLKKHEAFESDL 444

Query: 834 AGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLE 887
           A H+ R++ +      + E  ++ +  V A+  ++  +W+ L A   +RR+ LE
Sbjct: 445 AAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALE 498



 Score = 40.4 bits (93), Expect = 0.022
 Identities = 55/290 (18%), Positives = 115/290 (39%), Gaps = 32/290 (11%)

Query: 1315 TELNQAWSSLGK-RADQRKAKLGDSHDLQRF---LSDFRDLMS----WINGIRGLV-SSD 1365
            +++N AW  L +      +  L +   L+R       FR   S    W +G   ++   D
Sbjct: 362  SDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKD 421

Query: 1366 ELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQ 1425
                 ++  +ALL++H+   +++ A     +      Q+L    +Y SP +  +   +  
Sbjct: 422  YETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICD 481

Query: 1426 ERADLEKAWVQRRMMLDQCLEL-----QLFHRDCEQA---ENWMAAREAFLNTEDKGDSL 1477
            +  +L     +RR  L++  +L     QL+    ++A    NWM      L       ++
Sbjct: 482  QWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTI 541

Query: 1478 DSVEALIKKHEDFDKAI-NVQEEKIAAL----------QAFADQLIAAGHY---AKGDIS 1523
            + ++ L   HE F   + +  +E++A L          Q +   +     Y      +I+
Sbjct: 542  EEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN 601

Query: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTL-QQFSRDVDEIEAWISEKLQ 1572
             + + V     R    + E+ ++   ++ L +QF    + I  WI  K++
Sbjct: 602  GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKME 651



 Score = 38.5 bits (88), Expect = 0.083
 Identities = 27/78 (34%), Positives = 42/78 (53%), Gaps = 2/78 (2%)

Query: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSA-EALLKKHEALMSDLS 940
           RR +  D L A+++   A+  E+W   KE ++   DY     S  +ALLKKHEA  SDL+
Sbjct: 387 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLA 445

Query: 941 AYGSSIQALREQAQSCRQ 958
           A+   ++ +   AQ   +
Sbjct: 446 AHQDRVEQIAAIAQELNE 463


>gi|4557241 actinin, alpha 3 [Homo sapiens]
          Length = 901

 Score =  260 bits (665), Expect = 1e-68
 Identities = 156/500 (31%), Positives = 271/500 (54%), Gaps = 24/500 (4%)

Query: 1985 QFNWKADVVESWIGEKENSLKTDDYGRDL-SSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
            +F  KA + E+W   KE  L   DY   L   V+ LL + E F++ L A  Q+ + +I A
Sbjct: 412  KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAA-HQDRVEHIAA 470

Query: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
            L  +L    + ++ ++ +R  ++  +W  L   +  R+  L   +     ++ L L FA+
Sbjct: 471  LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530

Query: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIK 2163
            +A+ FN+W + A EDL D    +S+EE ++L  AHD F+++L  A  +   +  +  +I+
Sbjct: 531  RAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQ 590

Query: 2164 SF-------RVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2216
                       ++NPY   + + +   W  ++K++  R+  LQ+E  RQ+ N++LR++FA
Sbjct: 591  KICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFA 650

Query: 2217 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2276
              ANA   WIQ     +  G      +G+LE Q+   +++ Q I   ++ + ++E     
Sbjct: 651  AQANAIGPWIQAKVEEV--GRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQL 708

Query: 2277 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2336
            ++E+L+ DNK+T +S   +   W+QL     R  + +E Q+  R+  G+++E L EF   
Sbjct: 709  LQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRAS 768

Query: 2337 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2396
            F HFD+ ++G +   +F++CL S+GYDL  V       EF  I+  VDPN  G V+ Q +
Sbjct: 769  FNHFDRKRNGMMEPDDFRACLISMGYDLGEV-------EFARIMTMVDPNAAGVVTFQAF 821

Query: 2397 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2456
            + FM +RET    ++E++ ++F+ L+ + K Y+T EEL + L  +QA+YC+  M PY   
Sbjct: 822  IDFM-TRETAETDTTEQVVASFKILAGD-KNYITPEELRRELPAKQAEYCIRRMVPY--- 876

Query: 2457 KGRELPT-AFDYVEFTRSLF 2475
            KG   P  A DYV F+ +L+
Sbjct: 877  KGSGAPAGALDYVAFSSALY 896



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 90/428 (21%), Positives = 181/428 (42%), Gaps = 39/428 (9%)

Query: 1820 AHEPAIQGVLDTGKKLSDDNTI--GKEEIQQRLAQFVEHW--KELKQLAAARGQRLEESL 1875
            +H PA       GK +SD      G E++++      E W   E+++L     QRL+   
Sbjct: 362  SHRPAFMP--SEGKLVSDIANAWRGLEQVEKGY----EDWLLSEIRRL-----QRLQHLA 410

Query: 1876 EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAA-IQGLLKKHEAFETDFTVHKDRVNDV 1934
            E  +F       EAW   K  +++  DY   L   ++ LL++HEAFE+D   H+DRV  +
Sbjct: 411  E--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHI 468

Query: 1935 CTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE--NSAFLQF 1986
                Q+L + + H   +++S+ + +       G ++   + A +R  KL E  +   L+F
Sbjct: 469  AALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEF 528

Query: 1987 NWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQE--GIANITAL 2044
              +A    +W+      L+       +   Q+LLT  + F A L    +E   I  I   
Sbjct: 529  ARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGE 588

Query: 2045 KDQLLAAKHVQ----SKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
              ++     ++    +  I      +  +W  +     +R + L E  +  +  E L   
Sbjct: 589  IQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQ 648

Query: 2101 FAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
            FA +A+A   W +   E+   L   +  +  E++  LR+       ++ + + + ++L  
Sbjct: 649  FAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQ----EQNIINYKTNIDRLEG 704

Query: 2158 LDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQ 2217
              + ++   V  N +T ++ME +   W  L   I     E++ +   ++     +++  +
Sbjct: 705  DHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNE 764

Query: 2218 HANAFHQW 2225
               +F+ +
Sbjct: 765  FRASFNHF 772



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 56/212 (26%), Positives = 90/212 (42%), Gaps = 20/212 (9%)

Query: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
            + ++   WR L+Q        L  E  +L    H  ++F + A   + W   K + L+  
Sbjct: 375  VSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQR 434

Query: 1260 NYGHDLAS-VQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
            +Y   L   V+AL R+HE FE DLAA  D+V  +   A+ L +     A  +  +C  + 
Sbjct: 435  DYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAIC 494

Query: 1319 QAWSSLG----KRAD--QRKAKLGDSHD-LQ-RFLSDFRDLMSWINGIRGLVSSDELAKD 1370
              W +LG    KR D  +R  KL ++ D LQ  F        +W++G    +    L   
Sbjct: 495  DQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHS 554

Query: 1371 VTGAEALLERHQEHRT---EIDARAGTFQAFE 1399
            V   ++LL  H + +    E D   G     +
Sbjct: 555  VEETQSLLTAHDQFKATLPEADRERGAIMGIQ 586



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 70/310 (22%), Positives = 132/310 (42%), Gaps = 59/310 (19%)

Query: 136 EKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQ 195
           EK+ E+  KL  A +L++++R     + W+ ++        +G+    +  +Q+K E+F+
Sbjct: 287 EKLMEEYEKL--ASELLEWIRR---TVPWLENR--------VGEP--SMSAMQRKLEDFR 331

Query: 196 TDMAAHEE-RVNE-------VNQFAAKLIQEQHP-----EEELIKTKQDEVNAAWQRLKG 242
                H+  R+ E        N    KL     P     E +L+     ++  AW+ L+ 
Sbjct: 332 DYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVS----DIANAWRGLEQ 387

Query: 243 LA----------LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLAS-VQ 291
           +           ++R  +L   AE  R    + E  +W + KE++++  D+   L   V+
Sbjct: 388 VEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHE--AWTRGKEEMLSQRDYDSALLQEVR 445

Query: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
           ALLR+HE  E DLAA +D+V+ + A A  L +     A  +  + + +   W+ + TL  
Sbjct: 446 ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQ 505

Query: 352 ERHARLNDSYRLQRFLADFRDL-----------TSWVTEMKALINADELASDVAGAEALL 400
           +R   L    R+++ L     L            +W+      +    L   V   ++LL
Sbjct: 506 KRRDALE---RMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLL 562

Query: 401 DRHQEHKGEI 410
             H + K  +
Sbjct: 563 TAHDQFKATL 572



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 56/264 (21%), Positives = 106/264 (40%), Gaps = 36/264 (13%)

Query: 681 QQFNRNVEDIELWLYEVEGHLASDDYGKDLTN-VQNLQKKHALLEADVAAHQDRIDGITI 739
           ++F +     E W    E  L+  DY   L   V+ L ++H   E+D+AAHQDR++ I  
Sbjct: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470

Query: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQL--FR 791
            A++  +  + +A ++  + +A+  +++ L      +   + R +KL +++   QL   R
Sbjct: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530

Query: 792 DVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMV 851
                  W+               +   Q+LL  H   +A +       +A  ++G  M 
Sbjct: 531 RAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP------EADRERGAIMG 584

Query: 852 EEGHF-------------AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQ----- 893
            +G                   +     ++N KW+ ++     R Q L++ L  Q     
Sbjct: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNER 644

Query: 894 ---QYFADANEAESWMREKEPIVG 914
              Q+ A AN    W++ K   VG
Sbjct: 645 LRRQFAAQANAIGPWIQAKVEEVG 668



 Score = 55.5 bits (132), Expect = 7e-07
 Identities = 85/420 (20%), Positives = 160/420 (38%), Gaps = 63/420 (15%)

Query: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
            +++E+  KL  S+ L+   R V  +E  + E   +A     +D  + +      + Q+  
Sbjct: 288  KLMEEYEKLA-SELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKC 346

Query: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657
              E   +    ++R        L  R A   SE  +   ++ +A+ W+ L Q +   +  
Sbjct: 347  QLEINFNTLQTKLR--------LSHRPAFMPSEGKL---VSDIANAWRGLEQVEKGYEDW 395

Query: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGKDLAS-VNNLLKKHQLLE 1709
             L E  + Q      + F       + W    E +L+  DY   L   V  LL++H+  E
Sbjct: 396  LLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFE 455

Query: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769
            +D++AH+DR++ + + A  L      + + V  +   I  ++  + ++   RR  L    
Sbjct: 456  SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERME 515

Query: 1770 RL--------HQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEA---EL 1818
            +L         +F R      +W+      +        +   Q+L   H + +A   E 
Sbjct: 516  KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEA 575

Query: 1819 AAHEPAIQGVLDTGKKLSDDN-----------TIGKEEIQQRLAQFVEHWKELKQLAAAR 1867
                 AI G+    +K+               T+  ++I  +       W  +++L  +R
Sbjct: 576  DRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTK-------WDMVRKLVPSR 628

Query: 1868 GQRLEESLEYQ--------QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEA 1919
             Q L+E L  Q        QF A       WI  K+     E+ G   A + G L++  A
Sbjct: 629  DQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKV-----EEVGRLAAGLAGSLEEQMA 683



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 87/419 (20%), Positives = 165/419 (39%), Gaps = 52/419 (12%)

Query: 751  DAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED-EETWIREKEPIAAS 809
            D  N  +  E +   YE      + R Q+L     L + FR      E W R KE + + 
Sbjct: 377  DIANAWRGLEQVEKGYEDWLLSEIRRLQRLQ---HLAEKFRQKASLHEAWTRGKEEMLSQ 433

Query: 810  TNRGKDLIG-VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
             +    L+  V+ LL++H+A ++++A H+ R++ +      + E  +  A  V ++   +
Sbjct: 434  RDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI 493

Query: 869  NQKWEALKAKASQRRQDLE---------DSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
              +W+ L     +RR  LE         D LQ  ++   A    +W+      +      
Sbjct: 494  CDQWDNLGTLTQKRRDALERMEKLLETIDQLQL-EFARRAAPFNNWLDGAVEDLQDVWLV 552

Query: 920  KDEDSAEALLKKHE---ALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976
               +  ++LL  H+   A + +      +I  ++ + Q   Q        T   + L   
Sbjct: 553  HSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITL--- 609

Query: 977  DYQEKSPREVTMKKGDILTLLNSTN----KDWWKVEVNDRQGFVPAAYVKKLDPAQSASR 1032
                 SP+++  K   +  L+ S +    ++  + +VN+R     AA    + P   A  
Sbjct: 610  -----SPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKV 664

Query: 1033 ENL----------LEEQGSIALRQEQ--IDNQTRITKEAGSVSLRMKQ-VEELYHSLLEL 1079
            E +          LEEQ +   +QEQ  I+ +T I +  G   L  +  V +  H++  +
Sbjct: 665  EEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSM 724

Query: 1080 GEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK 1138
               R G  +       + R  NE++  +      LT +  G   EQ+   +  F+ F +
Sbjct: 725  EHIRVGWEQLLTS---IARTINEVENQV------LTRDAKGLSQEQLNEFRASFNHFDR 774



 Score = 48.5 bits (114), Expect = 8e-05
 Identities = 70/338 (20%), Positives = 132/338 (39%), Gaps = 42/338 (12%)

Query: 362 RLQRFLADFRDLTS----WVTEMKALINADELASDVAG-AEALLDRHQEHKGEIDAHEDS 416
           RLQ     FR   S    W    + +++  +  S +     ALL RH+  + ++ AH+D 
Sbjct: 405 RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464

Query: 417 FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-------DL 469
            +      Q L    ++ +  V  +   + ++   L  L + RR   E+          L
Sbjct: 465 VEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQL 524

Query: 470 QL-FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL-- 526
           QL F R     +NW+      L +  L  S++  ++LL  H+ F+ +L   + +  A+  
Sbjct: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584

Query: 527 ---------DEFATKLIQNNHY---AMEDVATR----RDALLSRRNALHERAMRRRAQLA 570
                      +  +    N Y   + +D+ T+    R  + SR   L E   R   Q  
Sbjct: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELAR---QQV 641

Query: 571 DSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSAN----QS 626
           +    +QF   ++ +  W+  K+    +E  +  + L G +++  A   +   N    ++
Sbjct: 642 NERLRRQFAAQANAIGPWIQAKV----EEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKT 697

Query: 627 RIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
            ID LE   Q L +   +        M  +   W++LL
Sbjct: 698 NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735



 Score = 48.5 bits (114), Expect = 8e-05
 Identities = 79/386 (20%), Positives = 145/386 (37%), Gaps = 43/386 (11%)

Query: 1769 HRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTG-VQNLRKKHKRLEAELAAHEPAIQG 1827
            H   +F +     E+W + K+ ++   DY   L   V+ L ++H+  E++LAAH+  ++ 
Sbjct: 408  HLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEH 467

Query: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
            +    ++L++ +      +  R     + W  L  L   R   LE   +  + +  ++ E
Sbjct: 468  IAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE 527

Query: 1888 EA--------WINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQ 1939
             A        W++  +  +       ++   Q LL  H+ F+       DR        Q
Sbjct: 528  FARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP-EADRERGAIMGIQ 586

Query: 1940 DLIKK--------NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWK-- 1989
              I+K               I+   + +N K   + K    R   L E  A  Q N +  
Sbjct: 587  GEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLR 646

Query: 1990 ------ADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
                  A+ +  WI       K ++ GR  + +   L +Q    AGL+  Q++ I N   
Sbjct: 647  RQFAAQANAIGPWI-----QAKVEEVGRLAAGLAGSLEEQM---AGLRQ-QEQNIINYKT 697

Query: 2044 LKDQLLAAKHV--QSKAIEARHA-----SLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2096
              D+L     +  +S   + +H       +   W QLL  S AR    +E Q   R  + 
Sbjct: 698  NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL-TSIARTINEVENQVLTRDAKG 756

Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDP 2122
            L      +  A  + F+     + +P
Sbjct: 757  LSQEQLNEFRASFNHFDRKRNGMMEP 782



 Score = 45.4 bits (106), Expect = 7e-04
 Identities = 71/378 (18%), Positives = 144/378 (38%), Gaps = 36/378 (9%)

Query: 3   PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
           PS  K++    +     +QV   Y  +      R Q+L+  +  + F++ A   E W + 
Sbjct: 369 PSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQ--HLAEKFRQKASLHEAWTRG 426

Query: 63  KLQIASDENYKDPT--NLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
           K ++ S  +Y       ++  L++H+AFE+++ A+   +  +      +    +  + ++
Sbjct: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486

Query: 121 RTRLMELHRQWE---LLLEKMR---EKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172
            +R   +  QW+    L +K R   E+  KLL+   Q  +++ R      +W++     +
Sbjct: 487 NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDL 546

Query: 173 TSEELGQDLEHVEVLQKKFEEFQTDM-AAHEER------VNEVNQFAAKLIQEQHPEEEL 225
               L   +E  + L    ++F+  +  A  ER        E+ +               
Sbjct: 547 QDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPY 606

Query: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277
           I     ++N  W  ++ L   R   L      Q+ N  +    +        WI+ K   
Sbjct: 607 ITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK--- 663

Query: 278 MASDDFGRDLASVQALLRKH-EGL---ERDLAALEDKVKALCAEADRLQQSHPLSATQIQ 333
              ++ GR  A +   L +   GL   E+++   +  +  L  +   LQ+S         
Sbjct: 664 --VEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTV 721

Query: 334 VKREELITNWEQIRTLAA 351
              E +   WEQ+ T  A
Sbjct: 722 YSMEHIRVGWEQLLTSIA 739



 Score = 45.1 bits (105), Expect = 9e-04
 Identities = 37/163 (22%), Positives = 76/163 (46%), Gaps = 17/163 (10%)

Query: 574 HLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAELSANQSRIDA 630
           HL + FR    L ++W   K +  +   Y       ++  +++H+AFE++L+A+Q R++ 
Sbjct: 408 HLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEH 467

Query: 631 LEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQ--------QQQ 682
           +    Q+L +++++    V +R   +   W  L   T+ +   L    +        Q +
Sbjct: 468 IAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE 527

Query: 683 FNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEA 725
           F R       WL   +G  A +D  +D+  V ++++  +LL A
Sbjct: 528 FARRAAPFNNWL---DG--AVEDL-QDVWLVHSVEETQSLLTA 564



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 17/180 (9%)

Query: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSL-DSVEALLKKHEDFE 513
           L E+RR Q  Q +  + F +     + W   +E  L   D   +L   V ALL++HE FE
Sbjct: 397 LSEIRRLQRLQHL-AEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFE 455

Query: 514 KSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-----------SRRNALHERA 562
             L+A ++++  +   A +L + +++    V +R  A+             RR+AL    
Sbjct: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALER-- 513

Query: 563 MRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDE-AYKDPSNLQGKVQKHQAFEAEL 621
           M +  +  D   L +F R +    +W++  ++   D          Q  +  H  F+A L
Sbjct: 514 MEKLLETIDQLQL-EFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATL 572



 Score = 33.1 bits (74), Expect = 3.5
 Identities = 64/309 (20%), Positives = 117/309 (37%), Gaps = 41/309 (13%)

Query: 1235 VQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFE-----------RDLA 1283
            ++ + + A E  EWI      L  +  G    S+ A+QRK E F            ++  
Sbjct: 290  MEEYEKLASELLEWIRRTVPWLE-NRVGEP--SMSAMQRKLEDFRDYRRLHKPPRIQEKC 346

Query: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKC-TELNQAWSSLGK----RADQRKAKLGDS 1338
             L    N+L +T  RL  SH  +    + K  +++  AW  L +      D   +++   
Sbjct: 347  QLEINFNTL-QTKLRL--SHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRL 403

Query: 1339 HDLQRFLSDFRDLMS----WINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDARAG 1393
              LQ     FR   S    W  G   ++S  D  +  +    ALL RH+   +++ A   
Sbjct: 404  QRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQD 463

Query: 1394 TFQAFEQFGQQLLAHGHYASPEIKQK----------LDILDQERADLEKAWVQRRMMLDQ 1443
              +      Q+L    ++ +  +  +          L  L Q+R D   A  +   +L+ 
Sbjct: 464  RVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRD---ALERMEKLLET 520

Query: 1444 CLELQL-FHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIA 1502
              +LQL F R      NW+      L       S++  ++L+  H+ F   +   + +  
Sbjct: 521  IDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERG 580

Query: 1503 ALQAFADQL 1511
            A+     ++
Sbjct: 581  AIMGIQGEI 589


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score =  258 bits (658), Expect = 7e-68
 Identities = 473/2464 (19%), Positives = 982/2464 (39%), Gaps = 250/2464 (10%)

Query: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY-RFQFFQRDAEELEKWIQEK--LQI 66
            + AE+ ++ ++++  R+ R  E++  R+++LE+S      FQ    +L  W+ EK  +  
Sbjct: 2977 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 3036

Query: 67   ASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTR 123
                   DP  L  + Q+ Q    E +A      +L+E    +++   +   ++  ++  
Sbjct: 3037 VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKE 3096

Query: 124  LMELHRQWELLLEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSE 175
            L  ++++W  L +K+  +        +K  Q Q+L+Q L E    V   ++ + AI T  
Sbjct: 3097 LQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQP 3156

Query: 176  E-LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234
            E + Q LE    ++   E+   ++   +   +E++     LI EQ+ ++EL K + + V 
Sbjct: 3157 EAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV----LIGEQYLKDEL-KKRLETVA 3211

Query: 235  AAWQRLKGLALQRQGKLFGA-AEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQA 292
               Q L+ LA  R  +L  A A  Q+F +  DE  +W+ +K+   A +      L  +Q+
Sbjct: 3212 LPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQS 3271

Query: 293  LLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ--IQVKREELITNWEQIRTLA 350
             L+++E  ++ L       + + AE + L  S P    +  +Q +  EL  +WE++    
Sbjct: 3272 QLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 3331

Query: 351  AERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGE 409
            A+R +RL D   + Q++     DL  W+ + KA ++   +  D    E+ L R +    E
Sbjct: 3332 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE 3391

Query: 410  IDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDL 469
            ++      +  + +   L+ +     D +R++   +++   A+ E  + +    E+    
Sbjct: 3392 VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMT-- 3449

Query: 470  QLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEF 529
            Q      E   N   K E      ++ D+L S     K  E     L AQ+E + AL+  
Sbjct: 3450 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE----KLRAQQEVLQALEPQ 3505

Query: 530  ATKLIQNNHYAMEDVATRRDA--LLSRRNALHERAMRRRAQL-ADSFHLQQFFRDSDELK 586
               L       +ED     DA  LL +     +  +  + ++ +    ++       +  
Sbjct: 3506 VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFH 3565

Query: 587  SWVNEKMKTATD---------EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
              V E      D            +D  +LQ +++  + F  ++   +  I+A E     
Sbjct: 3566 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA---- 3621

Query: 638  LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEV 697
              +  H  ++E      +++ L K+ LEA   +  KL E  + +Q     E +EL L  V
Sbjct: 3622 --ECRHMLEEEGTL---DLLGL-KRELEALNKQCGKLTERGKARQ-----EQLELTLGRV 3670

Query: 698  EGHLASDDYGKDLTNVQNLQKKHAL-----LEADVAAHQ---------DRIDGITIQARQ 743
            E          D T     ++  AL      E ++   Q         +++D + ++ +Q
Sbjct: 3671 EDFYRKLKGLNDATTAA--EEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3728

Query: 744  FQDAGH---------FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-V 793
                G           D + ++   E + AR+  L + +  R  +L ++L     F+D +
Sbjct: 3729 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDAL 3788

Query: 794  EDEETWIREKEPIAASTNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE 852
            E   +W+ + E + A+      +   V+  +++ + LQ  +   +  +  +  +G  + +
Sbjct: 3789 EPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ 3848

Query: 853  EGHFA-AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQQYFADANEAESWMREKE 910
                A  E +  +L  L  +W  L +KA+ R++ LED L  A+Q+   A     ++   E
Sbjct: 3849 SAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3908

Query: 911  P-IVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
              +  S   G      +  + +H+AL  D+  + + +    +  QS     +P +     
Sbjct: 3909 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968

Query: 970  ELVLALY----DYQEKSPREVTMKKG----------DILTLLNSTNKDWWKVEVNDRQGF 1015
            E + +L     + Q++  R+  +             D + +LN      W  EV D+   
Sbjct: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLN------WLAEVEDK--- 4019

Query: 1016 VPAAYVKKLDPAQSASRENLLEEQGS--IALRQEQIDNQTRITKEAGSVSLRMKQ----- 1068
            + + +VK         ++++L  Q +  +AL +E ++ +  + +   +    +KQ     
Sbjct: 4020 LSSVFVKDF-------KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 4072

Query: 1069 ----------VEELYHSLLELGEKRKGMLEKSCKKFMLFREA-NELQQWINEKEAAL-TS 1116
                      ++  Y  +     K    LE++ +    F+    EL  W+ E E  L TS
Sbjct: 4073 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 4132

Query: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
                   EQ+   Q++  + +K++  +   L  +N+V+  L         ++ V      
Sbjct: 4133 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL---------LELV------ 4177

Query: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA-HEV 1235
                          PW++   +   V+      + NE+++ +     +R   + +A    
Sbjct: 4178 --------------PWRAREGLDKLVS------DANEQYKLVSDTIGQRVDEIDAAIQRS 4217

Query: 1236 QRFHRDADETKEWIEE---KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSL 1292
            Q++ + AD    W+ E   K  AL       D  + Q   +K   F  D+    D ++ L
Sbjct: 4218 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK--AFSIDIIRHKDSMDEL 4275

Query: 1293 GETAERLIQSHPESAED-LQEKCTELNQAWSSLGKRADQRKAKLGDSHDL-QRFLSDFRD 1350
                  +  +  E  +  LQEK   L Q + ++     +R A+L  +  L  +F   + +
Sbjct: 4276 FSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE 4335

Query: 1351 LMSWINGIRGLVSS--------DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402
            L  WI   R L++         ++L +       L E   EH+  ID          + G
Sbjct: 4336 LSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL-------KIG 4388

Query: 1403 QQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL----ELQLFHRDCEQAE 1458
             QL          +++K    +   A +++   QR + LD+ +    ++  FH   E   
Sbjct: 4389 PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPML 4448

Query: 1459 NWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHY 1517
              +    + L       + +D +   I  ++     +   +    AL+   ++LI     
Sbjct: 4449 ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4508

Query: 1518 AKGDISSRR-NEVLDR----WRRLKAQMIEKRSK-LGESQTLQQFSRDVDEIEAWISEKL 1571
            A  D++++   + LD+    W  +KA+  E+  K L   +  ++F  D+  +   I +  
Sbjct: 4509 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQ 4568

Query: 1572 QTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE 1631
                D    +   I  S +  + +  +  + E     + +  +  +G  LI   AC  +E
Sbjct: 4569 DIVHD---LESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIF--ACGETE 4623

Query: 1632 DA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ--QNFNTGIKDFDFWLSEVEALLAS 1688
               V+  +  + + W+ L +   E+ +KL++A +   Q  +T    FD+  + V  L   
Sbjct: 4624 KPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4683

Query: 1689 EDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQ--VKDKRDT 1746
               G DL +V + L + +  + ++   +  ++ LN Q + ++  +  +T +  +++    
Sbjct: 4684 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4743

Query: 1747 INGRFQKIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKE-KKLLVGSEDYGRDLTGV 1804
            +   ++ +    A R+ KL  +   L QF   +++  SW+   ++LL        D   +
Sbjct: 4744 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4803

Query: 1805 QNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNT-IGKEEIQQRLAQFVEHWKELKQL 1863
            +    KH  L+ ++ AH+  ++ V   G +L + +       ++ RL    + W+ + Q 
Sbjct: 4804 EVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQK 4863

Query: 1864 AAARGQRLEESLEYQQ-FVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFE 1921
               R Q+L+ +L+  Q F + +E+    +   +  L AS+  G      +  L  H    
Sbjct: 4864 TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4923

Query: 1922 TDFTVHKDRVNDVCTNGQDLI--KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE 1979
            +     ++  N +   G+ ++  + ++         +  L  K   +     +RK+KL+E
Sbjct: 4924 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4983

Query: 1980 N-SAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
              +   +F        +W+   E SL         L++V + + + + F   + A + + 
Sbjct: 4984 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ- 5042

Query: 2038 IANITALKDQLLAAKHVQSKA-IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2096
            I  +    +QL      Q    I+    S+  RW +++  S  R + L +A+   ++  +
Sbjct: 5043 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 5102

Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDPVRC-NSLEEIKALREAHDAFRSSLSSAQADFNQL 2155
             +            W E+AE  L   +   N  ++IK     H  F+ +L   Q  ++  
Sbjct: 5103 AWKKLI-------DWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTT 5155

Query: 2156 AELDRQIKSFRVA---SNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR 2212
                R +K   +    S     F  E + + W  +     ER       Q + EE     
Sbjct: 5156 IRTGRALKEKTLLPEDSQKLDNFLGE-VRDKWDTVCGKSVER-------QHKLEEALLFS 5207

Query: 2213 QEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIED 2272
             +F     A   W+ +    L +   +  +   + + ++A K   +E+      ++ ++ 
Sbjct: 5208 GQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 5267

Query: 2273 LGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQA----RNTTGVTEE 2328
             G  + E    D  + +     L+ +WD + +L +  Q  LEQ ++     R+T  +  E
Sbjct: 5268 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 5327

Query: 2329 ALKE 2332
             L E
Sbjct: 5328 WLSE 5331



 Score =  250 bits (639), Expect = 1e-65
 Identities = 420/2047 (20%), Positives = 846/2047 (41%), Gaps = 198/2047 (9%)

Query: 3    PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
            P G    +     +  +Q+ L+   R      +   KLE   +F    R+       + +
Sbjct: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580

Query: 63   KLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD------ETGNLMISEGHFA 116
            +L        +D  +LQ +++  + F  ++      ++KLD      E  +++  EG   
Sbjct: 3581 ELD-GMGAIGRDTDSLQSQIEDVRLFLNKIH-----VLKLDIEASEAECRHMLEEEGTLD 3634

Query: 117  SETIRTRLMELHRQWELLLE--KMREKGIKLL--QAQKLVQYLRECEDVMDWINDKEAIV 172
               ++  L  L++Q   L E  K R++ ++L   + +   + L+   D      + EA+ 
Sbjct: 3635 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL- 3693

Query: 173  TSEELGQDLEHVEVLQKKFEEFQTDMAAH-EERVNEVNQFAAKLIQEQHPEEEL--IKTK 229
                +G ++E +      F+ FQ +     + ++ +VN     LIQ    + ++  ++  
Sbjct: 3694 -QWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD 3752

Query: 230  QDEVNAAWQRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDL 287
             +E+NA W  L     QR  +L  A     +F   ++  +SW+ + E+L+A+      + 
Sbjct: 3753 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3812

Query: 288  ASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ-IQVKREELITNWEQI 346
              V+A +++ + L+R L   +  V  L AE  R+ QS  L+  + I  + E L + W ++
Sbjct: 3813 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3872

Query: 347  RTLAAERHARLNDSYRLQRF-------LADFRDLTSWVTEMKALINADELASDVAGAEAL 399
             + AA R  +L D   L +        ++DF  +T      K L N++ + +  A  +  
Sbjct: 3873 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE-----KKLANSEPVGTQTAKIQQQ 3927

Query: 400  LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV-REKLTVLSEERAALLELWEL 458
            + RH+  + +I+ H      A + GQ+L +    A   V  EK+  L    + + +    
Sbjct: 3928 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3987

Query: 459  RRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFL------------LNEDLGDSLDSVEAL 505
            +    +Q + + +LF  D  +V NW+++ E  L            L+    D L   E +
Sbjct: 3988 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 4047

Query: 506  LKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATR-RDALLSRRNALHERAMR 564
            + + ++ ++++   +  +         LIQ     ++ + TR  D  ++   AL  R + 
Sbjct: 4048 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK---LDGIKTRYADITVTSSKAL--RTLE 4102

Query: 565  RRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKV--QKHQAFEAELS 622
            +  QLA  F         +EL  W+ E  +       + P+  Q     Q+ +  + E+ 
Sbjct: 4103 QARQLATKFQSTY-----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 4157

Query: 623  ANQSRIDALEKAGQKLIDVNHY-AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
             ++  +D + +  + L+++  + A++ +   +++    +K + +    +  ++  A Q+ 
Sbjct: 4158 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 4217

Query: 682  QFNRNVEDIEL-WLYEVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGI 737
            Q      D EL W+ E +  L +       +D T  Q LQ + A    D+  H+D +D +
Sbjct: 4218 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ-LQVQKAF-SIDIIRHKDSMDEL 4275

Query: 738  -TIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS-LRLQQLFRDVED 795
             + ++  F   G      +++K E+L+ +YEA+      R  +L  + + + Q +   E+
Sbjct: 4276 FSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE 4335

Query: 796  EETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRI----------KAVT 844
               WI E   + A   +   D   ++   ++ + L+  IA H+P I          K + 
Sbjct: 4336 LSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN 4395

Query: 845  QKGNAMVEEGHFAAEDVKAKL-HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE 903
             +   MVEE +  AE++ A++  E+ Q+  AL    SQ  Q  E   + +          
Sbjct: 4396 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLS 4455

Query: 904  SWMREKEPIVGSTDYGK----DEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
            S +R    I    D  +    D  SA   L+K +     L   G   + L  ++Q   + 
Sbjct: 4456 SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRG---EELIGRSQGADKD 4512

Query: 960  VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE-----VNDRQG 1014
            +A  + +   + ++  ++  +    E  +K  D+L L     K W+ +      + D Q 
Sbjct: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLEL---AEKFWYDMAALLTTIKDTQD 4569

Query: 1015 FVPAAYVKKLDPA----QSASRENLLEEQGSIALRQEQIDNQTRIT----------KEAG 1060
             V       +DP+    Q  + E + EE   +    E I    RI            E  
Sbjct: 4570 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFI----RILGADLIFACGETEKP 4625

Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAAL-TSEE 1118
             V   + ++   + +L +  ++R   LE + +  + +++  +    W++     L T   
Sbjct: 4626 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4685

Query: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGM 1178
            VG DL  V+    +  +F+ ++   +  ++ +N   E      LM ++            
Sbjct: 4686 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE------LMLKKAT---------- 4729

Query: 1179 MPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQR 1237
               DETD                      + EL   W +L +++A  + +L G+   + +
Sbjct: 4730 ---DETDRDIIR---------------EPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4771

Query: 1238 FHRDADETKEWIEEKNQALNTDN-YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETA 1296
            F    +E   W+    + L+       D   ++    KH   + D+ A    V ++ +  
Sbjct: 4772 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4831

Query: 1297 ERLIQSHP-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSW 1354
              L++S   + A  L+ +   +NQ W S+ ++ ++R+ +L  +    Q F S+  D +  
Sbjct: 4832 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4891

Query: 1355 INGIRGLVSSDELAKDVTG-AEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GHY 1411
            +  +   +S+ +    +   A   L+ H E  +++ A+  T+      G+ +L       
Sbjct: 4892 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4951

Query: 1412 ASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNT 1470
            +  + +Q + +L+Q+   +     +R+  L++ L L   F    ++  NW+   E  LN 
Sbjct: 4952 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011

Query: 1471 EDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRN-- 1527
                   L++V + I++H+ F   +N   ++I  L    +QL       K D+   +N  
Sbjct: 5012 ASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQ--KQDVVLIKNLL 5069

Query: 1528 -EVLDRWRRLKAQMIEKRSKLGESQT-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPT 1583
              V  RW ++  + IE+   L +++   +QF     ++  W+  +E    +  E   DP 
Sbjct: 5070 VSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPD 5129

Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALAD 1643
             I+L   LSKH++   F+  L          I  G +L E+         +   L  + D
Sbjct: 5130 KIKLQ--LSKHKE---FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRD 5184

Query: 1644 QWQFLVQKSAEKSQKLKEANK-QQNFNTGIKDFDFWLSEVEALLASED--YGKDLASVNN 1700
            +W  +  KS E+  KL+EA      F   ++    WL +VE  LA +   +G DL  V N
Sbjct: 5185 KWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMN 5243

Query: 1701 LLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAAS 1760
            L+  H++ + ++      ++ L      L+ +S  DT+ VK +   ++ R+  +  ++ S
Sbjct: 5244 LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVS 5303

Query: 1761 RRAKLNESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL 1818
            ++++L ++ +  + FRD +     W+ E ++ L        D   +Q+L   HK    ++
Sbjct: 5304 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 5363

Query: 1819 AAHEPAIQGVLDTGKKL-----SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
                  +   +  G+ +      D  T  K  I    A+F    +E+   A    QRLE 
Sbjct: 5364 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARF----EEVLTWAKQHQQRLET 5419

Query: 1874 SLEYQQFVAN---VEEEEAWINEKMTLVASED---YGDTLAAIQGLLKKHEAFETDFTVH 1927
            +L   + VAN   +EE  AWI    T +   D       +  ++ L+ +H+ F  + T  
Sbjct: 5420 AL--SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRK 5477

Query: 1928 KDRVNDV 1934
            +  V+ V
Sbjct: 5478 QPDVDRV 5484



 Score =  188 bits (477), Expect = 6e-47
 Identities = 443/2389 (18%), Positives = 917/2389 (38%), Gaps = 310/2389 (12%)

Query: 135  LEKMREKG-IKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEE---LGQDLEHVEVLQKK 190
            L++M ++  +K LQ Q+   + ++ ED+  W+   E  +   +     QDL  ++  Q  
Sbjct: 2035 LQQMEQEALVKTLQKQQNTCH-QQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSD 2093

Query: 191  FEEFQTDMAAH---------------EERVNEVNQFAAKLIQEQ-HPEEELIKTKQDEVN 234
             ++ Q D+                  EE   +++      ++E+ H  +E  +  Q+E  
Sbjct: 2094 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETR 2153

Query: 235  AAWQRLKGL---ALQRQGKLFGAA-EVQRFNRDVDETISWIKE--------------KEQ 276
             A + L+     ALQ++ +   AA E+    + +D  + W+                 EQ
Sbjct: 2154 VAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ 2213

Query: 277  LMASDDFGRDLASVQALL---RKHEGLERDLAALEDKVKALCAEADRL------------ 321
            L  +      L +    +   +  E L++    ++ + + L ++                
Sbjct: 2214 LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD 2273

Query: 322  QQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY----RLQRFLADFRDLTSWV 377
            Q  H L+  + Q+ +++L    EQ  T  A+  A L         LQ+FL D ++  SW+
Sbjct: 2274 QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 2333

Query: 378  TEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL-------- 428
                K L N  +  S      +LL R      ++ +H+   +    SGQ +L        
Sbjct: 2334 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 2393

Query: 429  -----AAGHYASDEVR---EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD 480
                   G+   D+++   E+ T L  +   L     +   QY Q      F    + + 
Sbjct: 2394 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQ------FQNSADSLQ 2447

Query: 481  NWMSKQEAF---LLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN 537
             WM   EA    LL++ +      ++  L   +  ++ L+  +  +  L + A  +++  
Sbjct: 2448 AWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2507

Query: 538  HYAMED---VATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK 594
                 D   V    D++LS   +L      R + L  +    Q  ++S  L+S +    +
Sbjct: 2508 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES--LESLLQSIGE 2565

Query: 595  TATDEAYKDPSNLQ-GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA-- 651
               +   K  S+L  G +Q+  A   +L  + +R  +  +A ++++       D   A  
Sbjct: 2566 VEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2625

Query: 652  ---RMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVEDIELWLYEVEGHLASDDY- 706
               ++ EV   +++L    + K   L++   Q + F      ++ ++      LAS +  
Sbjct: 2626 LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQP 2685

Query: 707  GKDLTNV-QNLQKKHALLEADVAAHQDRIDGITIQARQFQDAG-------HFD-AENIKK 757
             +D+T+  Q +Q+    L  ++   Q+ +D +     +    G       H D  +N++K
Sbjct: 2686 DQDITHFFQQIQE----LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRK 2741

Query: 758  KQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLI 817
                L    +  ++   + +++L +  +L + F      + W++E E     T       
Sbjct: 2742 DFTELQKTVKEREKDASSCQEQLDEFRKLVRTF------QKWLKETEGSIPPTETSMSAK 2795

Query: 818  GVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE------------------------- 852
             ++  ++  ++L  + A     ++ +  KG ++                           
Sbjct: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2855

Query: 853  ---EGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESW 905
                G+   +D   ++  + ++N K+E L     +R++ L+  L + ++   +AN    W
Sbjct: 2856 GSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQW 2915

Query: 906  MREKEPIVGSTDYGKDEDSAE---ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP 962
            +  KE ++ S D        E   A  + ++A +++L      IQ ++E           
Sbjct: 2916 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA---------- 2965

Query: 963  TDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEV-NDRQGFVPAAYV 1021
                    L   L  Y      E   K   I   LNS  +   +V V   RQ    A+++
Sbjct: 2966 --------LAGLLVTYPNSQEAENWKK---IQEELNSRWERATEVTVARQRQLEESASHL 3014

Query: 1022 KKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGE 1081
                 A+S  R  L+E++  + +      +   +  +   V   +K+ E       +L E
Sbjct: 3015 ACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNE 3074

Query: 1082 KRKGMLEKSCKKFMLFREANELQQWINEKEAALTSE--EVGADLEQVEVLQKKFDDFQKD 1139
              +G+L       +   +  +  Q IN+K   LT +     + ++Q  V   ++ +  +D
Sbjct: 3075 AAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQD 3134

Query: 1140 LKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ-----EVYGMMPRDETDSKTASPW-K 1193
            L       + +  V + L  +  ++ + +AV+QQ     E+   + + + + K A     
Sbjct: 3135 LS------EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCD 3188

Query: 1194 SARLMVHTVATFNSIKELNER----WRSLQQLAEER-SQLLGSAHEVQRFHRDADETKEW 1248
               +++      + +K+  E      + L+ LA +R ++L  +    Q+F +  DE + W
Sbjct: 3189 ELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTW 3248

Query: 1249 IEEK-NQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP--E 1305
            +++K +Q          L  +Q+  +++E F++ L         +    E L+ S P  E
Sbjct: 3249 LDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGE 3308

Query: 1306 SAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIRGLVSS 1364
                LQ +  EL   W  L K+   R+++L D     Q++     DL+ WI   +  +S 
Sbjct: 3309 EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE 3368

Query: 1365 DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILD 1424
              +  D    E+ L R +    E++ R    +        L+                 D
Sbjct: 3369 LRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE------------AD 3416

Query: 1425 QERADLEKAWVQRRM-MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDS------- 1476
            ++    EKA + + M  + + L+ +    + E  +     +E+F N E K +        
Sbjct: 3417 EDGIRDEKAGINQNMDAVTEELQAKTGSLE-EMTQRLREFQESFKNIEKKVEGAKHQLEI 3475

Query: 1477 LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQL--IAAGHYAKGDISSRRNEVLDRWR 1534
             D++ +    +++ +K +  Q+E + AL+   D L     G        S  +++L +  
Sbjct: 3476 FDALGSQACSNKNLEK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAE 3534

Query: 1535 RLKAQMIEKRSKLGES-------------------QTLQQFSRDVDEIEAWISEKLQTAS 1575
              + + +E + ++                      +   Q +   DE++   +    T S
Sbjct: 3535 VAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDS 3594

Query: 1576 DESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVK 1635
             +S  +   + L+K+       +A EAE     +   G +D+     E  A       + 
Sbjct: 3595 LQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EGTLDLLGLKRELEALNKQCGKLT 3653

Query: 1636 ARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDL 1695
             R  A  +Q +  + +  +  +KLK          G+ D      E EAL      G ++
Sbjct: 3654 ERGKARQEQLELTLGRVEDFYRKLK----------GLNDATTAAEEAEAL--QWVVGTEV 3701

Query: 1696 ASVNNLLKKHQLLEAD-ISAHEDRLKDLNSQADSLMTSSA--FDTSQVKDKRDTINGRFQ 1752
              +N  L   ++ + + +   + +L+ +N     L+ S+    D   ++   + IN R+ 
Sbjct: 3702 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWN 3761

Query: 1753 KIKSMAASRRAKLNESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKK 1810
             +    A R A+L E+      F+D ++   SW+ + ++L+   +    +   V+   ++
Sbjct: 3762 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3821

Query: 1811 HKRLEAELAAHEPAIQGVLDTGKKLSDDNTIG-KEEIQQRLAQFVEHWKELKQLAAARGQ 1869
             K L+  L   +  +  +   G +++    +  +E+I  +L      W EL   AAAR +
Sbjct: 3822 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3881

Query: 1870 RLEESLEY-QQFVANVEEEEAWIN-EKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVH 1927
            +LE+ L   +QF    E    +++  +  L  SE  G   A IQ  + +H+A E D   H
Sbjct: 3882 QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENH 3941

Query: 1928 KDRVNDVCTNGQDLIKKNNHHEENI-SSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQF 1986
               V+     GQ L    +  E+ + S K+  L  + S+++    ++ A LD+  +  + 
Sbjct: 3942 ATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL 4001

Query: 1987 NWKADV-VESWIGEKENSLKT---DDYGRDL---SSVQTLLTKQETFDAGLQAFQQEGIA 2039
              + +V V +W+ E E+ L +    D+ +D+        L   +E  +        + I 
Sbjct: 4002 FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNV--DQAIK 4059

Query: 2040 NITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFL 2099
            N  AL  Q    + +    I+ +   +  R++ +   S+   + L +A+        L  
Sbjct: 4060 NGQALLKQTTGEEVL---LIQEKLDGIKTRYADITVTSSKALRTLEQAR-------QLAT 4109

Query: 2100 TFAKKASAFNSWFENAEEDL-TDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAEL 2158
             F         W    EE+L T   +  + E+I   ++     +  +   +   + + E+
Sbjct: 4110 KFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEV 4169

Query: 2159 DRQIKSFRVASNPYTWFTMEALE-------ETWRNLQKIIKERELELQKEQRRQEENDKL 2211
             R +           W   E L+       E ++ +   I +R  E+    +R       
Sbjct: 4170 SRALLEL------VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS------ 4217

Query: 2212 RQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKI- 2270
             Q++ Q A+A   W+ ET+  L+    +  E     +QL+  K    +I   +  + ++ 
Sbjct: 4218 -QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELF 4276

Query: 2271 ----EDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQ 2315
                E  G   EE         +  T  L QQ++ +  L       LE+
Sbjct: 4277 SHRSEIFGTCGEE----QKTVLQEKTESLIQQYEAISLLNSERYARLER 4321



 Score =  168 bits (425), Expect = 7e-41
 Identities = 331/1803 (18%), Positives = 726/1803 (40%), Gaps = 216/1803 (11%)

Query: 9    LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRF-QFFQRDAEELEKWIQ--EKLQ 65
            L   E I  + + +  R+      +  R+++LED     + F   AE +  ++   EK  
Sbjct: 3852 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3911

Query: 66   IASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125
              S+        +Q ++ +H+A E +++ ++  + +  + G  + S    A + + +  +
Sbjct: 3912 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3971

Query: 126  E-LHRQWELLLEKMREKGIKLLQAQKLVQYLRECE-DVMDW---INDKEAIVTSEELGQD 180
            + L  ++  + ++   K   L QA    +   E E +V++W   + DK + V  ++  QD
Sbjct: 3972 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 4031

Query: 181  LEHVEVLQKKFEEFQTDMAAHEERVNE-------VNQFAAKLIQEQHPEEELIKTKQDEV 233
            + H         +    +A +EE VN        +    A L Q    E  LI+ K D +
Sbjct: 4032 VLH--------RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 4083

Query: 234  NAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETISWIKE-KEQLMASDDFGRDLASVQ 291
               +  +   + +    L  A ++  +F    +E   W++E +E+L  S         + 
Sbjct: 4084 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIP 4143

Query: 292  ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
               ++ + L++++      +  +   +  L +  P  A +     ++L+++  +   L +
Sbjct: 4144 QFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVS 4200

Query: 352  ERHARLNDSY-----RLQRFLADFRDLTSWVTEMKALINA--------DELASDVAGAEA 398
            +   +  D       R Q++        +WV E K  + A        D+  + +   +A
Sbjct: 4201 DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKA 4260

Query: 399  L---LDRHQEHKGEIDAHEDS-FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
                + RH++   E+ +H    F +  E  + +L     +  +  E +++L+ ER A LE
Sbjct: 4261 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 4320

Query: 455  LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514
              ++   Q         F+   E++  W+ +  A +    L       E L ++ E+  +
Sbjct: 4321 RAQVLVNQ---------FWETYEELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQ 4369

Query: 515  ---SLSAQEEKITALDEFATKLIQNNHYAMEDVATR----RDALLSRRNALHERAMRRRA 567
               S++  +  I  L +   +L + N    E V  +     +     +  + +RA+    
Sbjct: 4370 LRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDE 4429

Query: 568  QLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP------SNLQGKVQKHQAFEAEL 621
             ++ S  + +F    D+++  + E ++  +      P        ++  +  +++   EL
Sbjct: 4430 AVSQSTQITEFH---DKIEPML-ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVEL 4485

Query: 622  SANQSRIDALEKAGQKLIDVNHYAKDEVAAR-----MNEVISLWKKLLEATELKGIKLRE 676
               Q   +AL++ G++LI  +  A  ++AA+     +++++  W+          IK R 
Sbjct: 4486 EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED---------IKARA 4536

Query: 677  ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN------------VQNLQKKHALLE 724
              ++ +F   +E  E + Y++   L +    +D+ +             Q ++    + E
Sbjct: 4537 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4596

Query: 725  ADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
                 H++      + A      G  +   ++K  + +   +E L +    R +KL D++
Sbjct: 4597 ETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAM 4656

Query: 785  RLQQLFRD-VEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
            +    ++D ++    W+      +      G DL  V++ L + +  + E+   +  ++ 
Sbjct: 4657 QAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEK 4716

Query: 843  VTQKGNAMVEEGHFAAED--VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA- 899
            +  +G  M+++     +   ++  L EL   WE L  K + R+  LE +L A   F  A 
Sbjct: 4717 LNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHAL 4776

Query: 900  NEAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQ 958
             E  SW+   E ++ +      D    E  L KH  L +D+ A+ ++++ + +      +
Sbjct: 4777 EELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLE 4836

Query: 959  QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE---------- 1008
              A  D  + +  + A+    E   ++   ++  + + L        ++E          
Sbjct: 4837 SSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRME 4896

Query: 1009 ----VNDRQGFVPAAYVKKLDP-----AQSASRE---NLLEEQGSIALRQEQIDNQTRIT 1056
                 +   G +P    ++LD      +Q  ++E   N L ++G + L     D+    +
Sbjct: 4897 SQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR--DDSGSGS 4954

Query: 1057 KEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
            K   SV+L    +E+ +H +    E+RK  LE++      F+  N LQ++IN    A  S
Sbjct: 4955 KTEQSVAL----LEQKWHVVSSKMEERKSKLEEALNLATEFQ--NSLQEFINWLTLAEQS 5008

Query: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
              + +    +                       +N V   +E   + A EV A + Q + 
Sbjct: 5009 LNIASPPSLI-----------------------LNTVLSQIEEHKVFANEVNAHRDQII- 5044

Query: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHE-V 1235
                  E D +T +  K        V   N +  +  RW  + Q + ER + L  A +  
Sbjct: 5045 ------ELD-QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 5097

Query: 1236 QRFHRDADETKEWIEEKNQALNTD-NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGE 1294
            ++FH    +  +W+E+    L+++    +D   ++    KH+ F++ L       ++   
Sbjct: 5098 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 5157

Query: 1295 TAERLIQSH--PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
            T   L +    PE ++ L     E+   W ++  ++ +R+ KL ++     +F+   + L
Sbjct: 5158 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 5217

Query: 1352 MSWINGIRGLVSSDE-LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
            + W+  +   ++ D+ +  D+     L++ H+  + E+  R GT Q  ++ G++L+ +  
Sbjct: 5218 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 5277

Query: 1411 YASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAENWMAAREAFLN 1469
              +  +K +L  L      + K  V ++  L+Q L + ++F         W++  E  L 
Sbjct: 5278 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLR 5337

Query: 1470 TEDK-GDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGH--------YAKG 1520
                  D  +++++LI  H++F K +  +   + +  A  + ++A  H        +   
Sbjct: 5338 FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWIT 5397

Query: 1521 DISSRRNEVLDRWRRLKAQMIEKR-SKLGESQTLQQFSRDVDEIEAWISEKLQTASDESY 1579
             I +R  EVL  W +   Q +E   S+L  +  L      ++E+ AWI +  +T   +  
Sbjct: 5398 IIRARFEEVLT-WAKQHQQRLETALSELVANAEL------LEELLAWI-QWAETTLIQRD 5449

Query: 1580 KDPTNIQLSKLLSKHQKHQAFEAEL---HANADRIRGVIDMGN------SLIERGACAGS 1630
            ++P    + ++ +   +HQ F  E+     + DR+       N        IE+    G 
Sbjct: 5450 QEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR 5509

Query: 1631 E----------------DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKD 1674
            +                +A   R+  L+ +WQ +   + E+ +KL +A  +        +
Sbjct: 5510 KSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFAN 5569

Query: 1675 FDF 1677
            FDF
Sbjct: 5570 FDF 5572



 Score =  162 bits (410), Expect = 4e-39
 Identities = 441/2392 (18%), Positives = 914/2392 (38%), Gaps = 286/2392 (11%)

Query: 54   EELEKWIQEKLQIASDENYKDPTNLQGKLQK--------HQAFEAEVQ----ANSGAIVK 101
            E+L     EK  + + + Y        KL K        HQ   ++ Q    A   A   
Sbjct: 2212 EQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAF 2271

Query: 102  LDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMRE--KGIKLLQAQKLVQYLRECE 159
            LD+ G+ +  E     + ++ +L EL  Q+   L +     K ++ LQ  +L ++L++ +
Sbjct: 2272 LDQHGHNLTPE---EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQ-DELQKFLQDHK 2327

Query: 160  DVMDWINDKEA-IVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQE 218
            +   W+   E  +    + G   E +  L K+   F  D+ +H+  +  V     K++  
Sbjct: 2328 EFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDM 2387

Query: 219  QHPEEE---------LIKTKQDEVNAAWQRLKGLALQRQGKL-FGAAEVQRFNRDVDETI 268
            ++  +E         L+K K  +    +  L     +    L     +  +F    D   
Sbjct: 2388 ENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQ 2447

Query: 269  SWIKEKE---QLMASDDFGRDLASVQALLRKHEGLERDLAALE---DKVKALCAEADRLQ 322
            +W++  E   + + SD    D   +Q  L   + L+ +LA  +   +K++ +  +   ++
Sbjct: 2448 AWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2507

Query: 323  QSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSY-RLQRFLADFRDLTSWVTEMK 381
                     +Q   + ++++++ +    AER + L  +  + Q        L   + E++
Sbjct: 2508 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2567

Query: 382  ALINADELASDVAGA-EALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVRE 440
              +   +++S  +G  +  L  + + K +I   + S ++  E     +      +  V +
Sbjct: 2568 QNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQ 2627

Query: 441  -KLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN------- 492
             KL  +S+         +L  QQ E+   L+      E  ++   K + F+ N       
Sbjct: 2628 GKLAEVSQR------FEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS 2681

Query: 493  -----EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDE--FATKLIQNNHYAMEDVA 545
                 +D+      ++ L  + ED +++L   E  +T L    FA  L Q+     + V 
Sbjct: 2682 GNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQ----DRVQ 2737

Query: 546  TRRDALLSRRNALHER---AMRRRAQLADSFHLQQFFR-----------------DSDEL 585
              R      +  + ER   A   + QL +   L + F+                  + EL
Sbjct: 2738 NLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKEL 2797

Query: 586  KSWVNEKMKTATDEAYK----DPSNLQGKVQKHQAFEAELSANQSRIDA-LEKAGQKLID 640
            +  +        D A K    +  N +G   ++   E     +Q +  + L   G  +  
Sbjct: 2798 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2857

Query: 641  VN--HYAKD--EVAARMNEVISLWKKLLEATELKGIKLREA-NQQQQFNRNVEDIELWLY 695
            VN  H  KD  E+   M++V   ++KL      +   L+   N+ ++ ++    +  WL 
Sbjct: 2858 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2917

Query: 696  EVEGHLASDDYGKDLTNVQNLQ-----KKHALLEAD-----VAAHQDRIDGITIQARQFQ 745
              E  L S D     T  + ++      K  L E +     +   ++ + G+ +     Q
Sbjct: 2918 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2977

Query: 746  DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDE-ETWIREKE 804
            +A     EN KK QE L +R+E   E  VAR+++L +S      F+  E +   W+ EKE
Sbjct: 2978 EA-----ENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032

Query: 805  -------PIAASTNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKA----VTQKGNAMVE 852
                   P++   N        VQ +LK+ +A + +   HE   +A    +T  G+  + 
Sbjct: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ---HEQLNEAAQGILTGPGDVSL- 3088

Query: 853  EGHFAAEDVKAKLHELNQKW----EALKAKASQRRQDLEDSLQAQQYFADANEAESWMRE 908
                +   V+ +L  +NQKW    + L +++SQ  Q +  S Q Q+   D +E    + +
Sbjct: 3089 ----STSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQ 3144

Query: 909  KEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAP--TDDE 966
            +  +   +      ++ +  L++   + SDL      ++  +         +      DE
Sbjct: 3145 RLSV--QSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202

Query: 967  TGKEL---VLALYDYQEKSPREVTMKKGDILTLLNSTNK-----DWWKVEVNDRQG--FV 1016
              K L    L L   ++ +   +      +   L ST +     D  +  ++D+Q     
Sbjct: 3203 LKKRLETVALPLQGLEDLAADRINR----LQAALASTQQFQQMFDELRTWLDDKQSQQAK 3258

Query: 1017 PAAYVKKLDPAQSASREN------LLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVE 1070
                  KL+  QS  +EN      L +  GS  +   + ++                Q+ 
Sbjct: 3259 NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLV 3318

Query: 1071 ELYHSLLELGEK---RKGMLEKSCKKFMLFR-EANELQQWINEKEAALTSEEVGADLEQV 1126
            EL +   EL +K   R+  L+   +K   ++    +L  WI + +A ++   V  D  Q+
Sbjct: 3319 ELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQL 3378

Query: 1127 EVLQKKFDDFQKDLKANESRLKDINKVAE------DLESEGLMAEEVQAVQQQEVYGMMP 1180
            E    +      +++   S L+ +N  A+      + + +G+  E+    Q  +      
Sbjct: 3379 ESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV---- 3434

Query: 1181 RDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEE-RSQLLGSAHEVQRFH 1239
             +E  +KT                  S++E+ +R R  Q+  +    ++ G+ H+++ F 
Sbjct: 3435 TEELQAKT-----------------GSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIF- 3476

Query: 1240 RDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERL 1299
                               D  G    S + L+ K    +  L AL  +V+ L    + L
Sbjct: 3477 -------------------DALGSQACSNKNLE-KLRAQQEVLQALEPQVDYLRNFTQGL 3516

Query: 1300 IQSHPE---------SAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSH-DLQRFLSDFR 1349
            ++  P+          AE  Q++  E+ Q  +S     + +   +G  H  ++   S   
Sbjct: 3517 VEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLA 3576

Query: 1350 DLMSWINGIRGL-VSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH 1408
            DL   ++G+  +   +D L   +      L +    + +I+A         +    L   
Sbjct: 3577 DLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA------ECRHMLEEE 3630

Query: 1409 GHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL-ELQLFHRDCEQAEN-WMAAREA 1466
            G      +K++L+ L+++   L +    R+  L+  L  ++ F+R  +   +   AA EA
Sbjct: 3631 GTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEA 3690

Query: 1467 FLNTEDKGDSLDSVEALIKKHEDFDK-AINVQEEKIAALQAFADQLI--AAGHYAKGDIS 1523
                   G  ++ +   +   + F K  ++  + K+  +      LI  A        + 
Sbjct: 3691 EALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLE 3750

Query: 1524 SRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPT 1583
                E+  RW  L  ++ ++ ++L E+  L    +  D +E  +S    T    + + P 
Sbjct: 3751 HDMEEINARWNTLNKKVAQRIAQLQEA--LLHCGKFQDALEPLLSWLADTEELIANQKPP 3808

Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDM---GNSLIERGACAGSEDAVKARLAA 1640
            + +   + ++ Q+ +  +  L    D  +  +DM       I + A     + +  +L +
Sbjct: 3809 SAEYKVVKAQIQEQKLLQRLL----DDRKATVDMLQAEGGRIAQSAELADREKITGQLES 3864

Query: 1641 LADQWQFLVQKSAEKSQKLKE-ANKQQNFNTGIKDFDFWLSEVEALLA-SEDYGKDLASV 1698
            L  +W  L+ K+A + ++L++     + F+   +    +LS  E  LA SE  G   A +
Sbjct: 3865 LESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKI 3924

Query: 1699 NNLLKKHQLLEADISAHEDRLKDLNSQADSLMT-SSAFDTSQVKDKRDTINGRFQKIKSM 1757
               + +H+ LE DI  H   +        SL + +S  +   + +K D++  R+ +I+  
Sbjct: 3925 QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3984

Query: 1758 AASRRAKLNES-HRLHQFFRDMDDEESW---IKEKKLLVGSEDYGRDLTGVQNLRKKHKR 1813
               + A L+++      F  D  +  +W   +++K   V  +D+ +D+   Q+    H  
Sbjct: 3985 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQH--ADHLA 4042

Query: 1814 LEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE--IQQRLAQFVEHWKELKQLAAARGQRL 1871
            L  E+   +  +   +  G+ L    T G+E   IQ++L      + ++   ++   + L
Sbjct: 4043 LNEEIVNRKKNVDQAIKNGQALLKQTT-GEEVLLIQEKLDGIKTRYADITVTSSKALRTL 4101

Query: 1872 EESLEY-QQFVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHK- 1928
            E++ +   +F +  EE   W+ E +  L  S     T   I    ++ +  + +   H+ 
Sbjct: 4102 EQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRL 4161

Query: 1929 --DRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDEN-SAFLQ 1985
              D VN+V     +L+       E +   +   N +   +     QR  ++D       Q
Sbjct: 4162 VLDTVNEVSRALLELVPW--RAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219

Query: 1986 FNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ---AFQQEGIANIT 2042
            +   AD   +W+ E +         R L ++  +  +Q+   A LQ   AF  + I +  
Sbjct: 4220 YEQAADAELAWVAETK---------RKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKD 4270

Query: 2043 ALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFA 2102
            ++ +       +     E +   L ++   L+    A      E  +   + + L   F 
Sbjct: 4271 SMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFW 4330

Query: 2103 KKASAFNSWFENAEEDLTD-PVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQ 2161
            +     + W E     +   P      E+++  +E     R S++  +   ++L ++  Q
Sbjct: 4331 ETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ 4390

Query: 2162 IKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQ----EENDKLRQEFAQ 2217
            +K              +  E  +  +++ +++R L L +   +     E +DK+      
Sbjct: 4391 LKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLET 4450

Query: 2218 HANAFHQW---------IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEI 2260
              N   +          + + R  + D      E   L+   EA KR+ +E+
Sbjct: 4451 LENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEEL 4502



 Score =  115 bits (289), Expect = 4e-25
 Identities = 363/2064 (17%), Positives = 787/2064 (38%), Gaps = 342/2064 (16%)

Query: 445  LSEERAALLELWELRRQQYEQCMDLQL--FYRDTEQVDNWMSKQEAFLLNEDL-----GD 497
            L +  +++ + W  R   ++  ++++         Q++  +    A++ N++L     G 
Sbjct: 1891 LQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGS 1950

Query: 498  S----LDSVEALLKKHEDFEKSLSAQEEKITAL--------DEFATKLIQNNHYAM---- 541
            +    +DS+   L+++ED ++ ++ ++ ++ AL         E A  L    +  M    
Sbjct: 1951 NSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLL 2010

Query: 542  -----------EDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVN 590
                       E  A + DAL      + + A+ +  Q   +   QQ     ++L SWV 
Sbjct: 2011 NELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQL----EDLCSWVG 2066

Query: 591  EKMK--------------TATDEAYKDPSNLQGKVQKH--------QAFEAELSANQSRI 628
            +  +              +A  +   D  +LQ  +Q          +  E  +  NQ+++
Sbjct: 2067 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKL 2126

Query: 629  DALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT----ELKGIKLREANQQQQFN 684
               E     L +  H AK++  A   E     K+L EA     + +  K + A +  +  
Sbjct: 2127 SPRELTA--LREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENK 2184

Query: 685  RNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQ-------KKHALLEAD----------- 726
            + ++ +  W+  V         G+ LTN+  ++       +K AL   D           
Sbjct: 2185 KKIDALLDWVTSV-----GSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEK 2239

Query: 727  --------VAAHQDRIDG------ITIQARQFQDA-GH----FDAENIKKKQEALVARYE 767
                     A HQ+ +         T  A+ F D  GH     + + +++K   L  +Y 
Sbjct: 2240 LDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYS 2299

Query: 768  ---ALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNR-GKDLIGVQNLL 823
               A  E  + + Q L D   LQ+  +D ++ E+W+   E    + ++ G     + +LL
Sbjct: 2300 TSLAQSEAELKQVQTLQD--ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLL 2357

Query: 824  KKHQALQAEIAGHEPRIKAVTQKGNAMVE------EGHFAAED---VKAKLHELNQKWEA 874
            K+  +   ++  H+  ++ VT  G  +++      EG   +E    VK KL +  +++ A
Sbjct: 2358 KRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTA 2417

Query: 875  LKAKASQRRQDLEDSL-QAQQYFADANEAESWMREKEPIVG---STDYGKDEDSAEALLK 930
            L +K ++    L   L Q  Q+   A+  ++WM+  E  V    S     D    +  L 
Sbjct: 2418 LHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLA 2477

Query: 931  KHEALMSDLSAYGSSIQALREQAQSC----------RQQVAPTDDETGKELVLALYDYQE 980
              + L  +L+ +   ++ L++ A+             + V  T D          Y   E
Sbjct: 2478 TTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE 2537

Query: 981  KSP--REVTMKKGDILTLLNSTNKDWWKVEVN---DRQGFVPAAYVKKLDPAQSASRENL 1035
            +S   ++   +   +   L S  +   +VE N    +   + +  +++        ++++
Sbjct: 2538 RSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDI 2597

Query: 1036 LEEQGSIALRQEQIDN--QTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKK 1093
              ++ S+   +E +    +T  +  A  +  ++ +V + +  L    ++++  L+K   +
Sbjct: 2598 ARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQ 2657

Query: 1094 FMLFRE-ANELQQWINEKEAALTS-----EEVGADLEQVEVLQKKFDDFQKDLKANESRL 1147
              +F   + +LQQ++  K   L S     +++    +Q++ L  + +D Q++L   E  +
Sbjct: 2658 AEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLV 2717

Query: 1148 KDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNS 1207
             +++     L+            Q Q+                                 
Sbjct: 2718 TELSSCGFALD----------LCQHQD--------------------------------R 2735

Query: 1208 IKELNERWRSLQQLAEERSQLLGSAHE-VQRFHRDADETKEWIEEKNQALNTDNYGHDLA 1266
            ++ L + +  LQ+  +ER +   S  E +  F +     ++W++E   ++          
Sbjct: 2736 VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAK 2795

Query: 1267 SVQALQRKHEGFERDLAALG---DKVNSLGETAERLIQSHPESAEDLQEKC-TELNQAWS 1322
             ++      +    D A+ G   +++N  G + E LI     +A D Q K  + L    S
Sbjct: 2796 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME--ITAPDSQGKTGSILPSVGS 2853

Query: 1323 SLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQ 1382
            S+G        K  D  ++Q  +SD       + G+        L +     +A+L R +
Sbjct: 2854 SVGSVNGYHTCK--DLTEIQCDMSDVNLKYEKLGGV--------LHERQESLQAILNRME 2903

Query: 1383 EHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE-IKQKLDILDQERADLEKAWVQRRMML 1441
            E   E ++     ++ E+  + + A       E +K + +      A+LE+   + + + 
Sbjct: 2904 EVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVK 2963

Query: 1442 DQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKI 1501
            +    L + + + ++AENW   +E   +  ++     + E  + +    +++ +     +
Sbjct: 2964 EALAGLLVTYPNSQEAENWKKIQEELNSRWER-----ATEVTVARQRQLEESAS----HL 3014

Query: 1502 AALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVD 1561
            A  QA   Q                         L+  ++EK   +G    L   S D +
Sbjct: 3015 ACFQAAESQ-------------------------LRPWLMEKELMMG---VLGPLSIDPN 3046

Query: 1562 EIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSL 1621
             + A              K      L +  ++ Q+H+    +L+  A  I         L
Sbjct: 3047 MLNA-------------QKQQVQFMLKEFEARRQQHE----QLNEAAQGI---------L 3080

Query: 1622 IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA-NKQQNFNTGIKDFDFWLS 1680
               G  + S   V+  L ++  +W  L  K   +S ++ +A  K   +   ++D    + 
Sbjct: 3081 TGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVR 3140

Query: 1681 EV-EALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQAD--SLMTSSAFDT 1737
             V + L           +V   L++   + +D+   +  +K+  +  D  S++    +  
Sbjct: 3141 AVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200

Query: 1738 SQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDE-ESWIKEKKLLVGSE- 1795
             ++K + +T+    Q ++ +AA R  +L  +    Q F+ M DE  +W+ +K+       
Sbjct: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260

Query: 1796 DYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEE--IQQRLAQF 1853
                 L  +Q+  ++++  +  L  H  + + ++  G+ L      G+E+  +Q +L + 
Sbjct: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320

Query: 1854 VEHWKELKQLAAARGQRLEESLE-YQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQG 1912
              HW+EL +  A R  RL++ ++  Q++  +VE+   WI +    ++          ++ 
Sbjct: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLES 3380

Query: 1913 LLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQ 1972
             L + +A   +    +  +  + +    LI  +   E+ I  +  G+N  +  + +    
Sbjct: 3381 SLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQA 3440

Query: 1973 RKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDA-GLQ 2031
            +   L+E +  L+             E + S K  +       V+    + E FDA G Q
Sbjct: 3441 KTGSLEEMTQRLR-------------EFQESFKNIE-----KKVEGAKHQLEIFDALGSQ 3482

Query: 2032 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHF 2091
            A   + +  + A ++ L        +A+E +    ++ ++Q L   A       +     
Sbjct: 3483 ACSNKNLEKLRAQQEVL--------QALEPQ-VDYLRNFTQGLVEDAPDGSDASQLLHQA 3533

Query: 2092 RKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQAD 2151
               +  FL   ++ ++     EN  E +     C   E    L +  D     L    A 
Sbjct: 3534 EVAQQEFLEVKQRVNSGCVMMENKLEGI-GQFHCRVREMFSQLADLDD----ELDGMGAI 3588

Query: 2152 FNQLAELDRQIKSFRVASNP--YTWFTMEALEETWRN-------LQKIIKERELE-LQKE 2201
                  L  QI+  R+  N        +EA E   R+       L  +  +RELE L K+
Sbjct: 3589 GRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ 3648

Query: 2202 QRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLE----SQLEATKR-- 2255
              +  E  K RQE  +      +        L D +   EE+  L+    +++E   +  
Sbjct: 3649 CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQL 3708

Query: 2256 ------KHQEIRAMRSQLKKIEDLGAAMEEAL--ILDNKYTEHSTVGLAQQWDQLDQLGM 2307
                  + +++  ++ +L+++  LG  + ++     D +  EH    +  +W+ L++   
Sbjct: 3709 ADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK--- 3765

Query: 2308 RMQHNLEQQIQARNTTGVTEEALK 2331
            ++   + Q  +A    G  ++AL+
Sbjct: 3766 KVAQRIAQLQEALLHCGKFQDALE 3789



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 332/1813 (18%), Positives = 689/1813 (38%), Gaps = 256/1813 (14%)

Query: 710  LTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEAL 769
            L N++   K+   LE ++A  QD +    +  R+ +D     ++ ++   + ++++ + +
Sbjct: 1817 LRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEV 1876

Query: 770  KEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNL--LKKHQ 827
               ++   +K  D+  LQ+    V D  TW                L+  QN   ++K +
Sbjct: 1877 PAQLLKALEK--DAKNLQKSLSSVSD--TW-------------NSRLLHFQNAVEIEKTK 1919

Query: 828  ALQ--AEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQD 885
             L    ++ G    ++A     N ++      +E     L+   Q++E LK   ++R+  
Sbjct: 1920 VLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQ 1979

Query: 886  LEDSLQAQQYFADANEAESWMREKEPIVGSTD--YGKDEDSAEALLKKHEALMSDLSAYG 943
            L+      Q+F   +  +   ++   ++   +      +D  E    + +AL   L    
Sbjct: 1980 LDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQME 2039

Query: 944  SS--IQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPRE----VTMKKGDILTLL 997
                ++ L++Q  +C QQ+       G +   AL  +Q ++ ++    +   + D+  L 
Sbjct: 2040 QEALVKTLQKQQNTCHQQLEDLCSWVG-QAERALAGHQGRTTQQDLSALQKNQSDLKDLQ 2098

Query: 998  NSTNK--DWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRI 1055
            +        +   V D +GF+     K      +A RE L + +     + E +  +TR+
Sbjct: 2099 DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE----QYEALQEETRV 2154

Query: 1056 TKEAGSVSLRMKQVEELYHSLLELG-EKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
             +         K++EE   S L+   EK K   E +  K    ++ + L  W+       
Sbjct: 2155 AQ---------KELEEAVTSALQQETEKSKAAKELAENK----KKIDALLDWVTS--VGS 2199

Query: 1115 TSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLES--EGLMAEEVQAVQQ 1172
            +  ++  +L  +E L       +K           +N+  E L+   E + A   + + Q
Sbjct: 2200 SGGQLLTNLPGMEQLSGA--SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQ 2257

Query: 1173 QEVYGMMPRD-----ETDSKTASPWKSARLMVHTVATFNSIKELNERWR-SLQQLAEERS 1226
            Q+ + +  +      +      +P +   L          + EL E++  SL Q   E  
Sbjct: 2258 QQNFILATQSAQAFLDQHGHNLTPEEQQMLQ-------QKLGELKEQYSTSLAQSEAELK 2310

Query: 1227 QLLGSAHEVQRFHRDADETKEWIEEKNQAL-NTDNYGHDLASVQALQRK----------H 1275
            Q+     E+Q+F +D  E + W+E   + L N    G    ++ +L ++          H
Sbjct: 2311 QVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISH 2370

Query: 1276 EGFERDLAALGDKVNSL------GETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRAD 1329
            +G  R +   G KV  +      G+    +     +  +D  E+ T L+   + LG   +
Sbjct: 2371 KGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLN 2430

Query: 1330 QRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS---SDELAKD-------VTGAEALLE 1379
                 LG  H   +F +    L +W+      V    SD +A D       +   + L E
Sbjct: 2431 M---LLGQYH---QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQE 2484

Query: 1380 RHQEHRTEID-ARAGTFQAFEQFGQQLLAHGHYASPEIK-----QKLDILDQERADLEKA 1433
               EH+  ++  +       E  G+    H H            Q L     ER+ L + 
Sbjct: 2485 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2544

Query: 1434 WVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDK- 1492
             + +   + + LE  L  +   + E  +  ++  +++   G   +++   +K  +D  + 
Sbjct: 2545 AIAQSQSVQESLESLL--QSIGEVEQNLEGKQ--VSSLSSGVIQEALATNMKLKQDIARQ 2600

Query: 1493 --AINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGE- 1549
              ++    E +      AD   AA       +  +  EV  R+ +L  Q  EK S L + 
Sbjct: 2601 KSSLEATREMVTRFMETADSTTAA------VLQGKLAEVSQRFEQLCLQQQEKESSLKKL 2654

Query: 1550 SQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANAD 1609
                + F     +++ ++  K +  +  +  D        +    Q+ Q    E+    D
Sbjct: 2655 LPQAEMFEHLSGKLQQFMENKSRMLASGNQPD------QDITHFFQQIQELNLEME---D 2705

Query: 1610 RIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ---- 1665
            +   +  + + + E  +C  + D     L    D+ Q L +   E  + +KE  K     
Sbjct: 2706 QQENLDTLEHLVTELSSCGFALD-----LCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760

Query: 1666 ----QNFNTGIKDFDFWLSE-------VEALLASEDYGKDLASVNNLL----KKHQLLE- 1709
                  F   ++ F  WL E        E  +++++  K +  + +LL     K  L+E 
Sbjct: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820

Query: 1710 ------------ADISAHEDRLKD---LNSQADSLMTSSAF----DTSQVKDKRDTINGR 1750
                         +I+A + + K    L S   S+ + + +    D ++++     +N +
Sbjct: 2821 INCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2880

Query: 1751 FQKIKSMAASRRAKLNE-SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLR- 1808
            ++K+  +   R+  L    +R+ +  ++ +    W++ K+ ++ S D     T  + ++ 
Sbjct: 2881 YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA 2940

Query: 1809 --KKHKRLEAELAAHEPAIQGVLD--TGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLA 1864
              + +K   AEL  + P IQ V +   G  ++  N+   E  ++   +    W+   ++ 
Sbjct: 2941 QAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVT 3000

Query: 1865 AARGQRLEESLEYQQ-FVANVEEEEAWINEKMTLVA-----SEDYGDTLA---AIQGLLK 1915
             AR ++LEES  +   F A   +   W+ EK  ++      S D     A    +Q +LK
Sbjct: 3001 VARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLK 3060

Query: 1916 KHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISS-------KMKGLNGKVSDLEK 1968
            + EA         +    + T   D+    +  ++ + S           LN + S +++
Sbjct: 3061 EFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQ 3120

Query: 1969 A---AAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLK-----TDDYGRDLSSVQTLL 2020
            A   + Q +  L + S  ++   +   V+S I  +  ++K     T +   DL  +   +
Sbjct: 3121 AIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 3180

Query: 2021 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2080
             + +T    L     E       LKD+L   K +++ A+       ++    L A+   R
Sbjct: 3181 KEAQTLCDELSVLIGE-----QYLKDEL--KKRLETVALP------LQGLEDLAADRINR 3227

Query: 2081 KKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDA 2140
             +  L +   F+++ D   T+           + +++    P+    LE +++  + ++ 
Sbjct: 3228 LQAALASTQQFQQMFDELRTWLDD--------KQSQQAKNCPISA-KLERLQSQLQENEE 3278

Query: 2141 FRSSLSSAQADFNQL-AELDRQIKSFRVASNPYTWFT-MEALEETWRNLQKIIKERELEL 2198
            F+ SL+     +  + AE +  + S        T    +  L+  W  L K   +R    
Sbjct: 3279 FQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR---- 3334

Query: 2199 QKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQ 2258
               Q R ++  +  Q++  H      WI++ +  + +    ++    LES L  +K    
Sbjct: 3335 ---QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSKAMLN 3390

Query: 2259 EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQ 2318
            E+   RS L+ +      +  +   D         G+ Q  D            + +++Q
Sbjct: 3391 EVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDA-----------VTEELQ 3439

Query: 2319 ARNTTGVTEE---ALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPE 2375
            A+  TG  EE    L+EF   FK+ +K   G  +  E    L S       +E+     E
Sbjct: 3440 AK--TGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQE 3497

Query: 2376 FEAILDTVDPNRD 2388
               +L  ++P  D
Sbjct: 3498 ---VLQALEPQVD 3507



 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 91/435 (20%), Positives = 178/435 (40%), Gaps = 37/435 (8%)

Query: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDA-EELEKWIQE-KLQIA 67
            E ++ +     +V D++      S  R+ KLE++  F     DA + L  W+ + + Q+A
Sbjct: 5170 EDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLA 5229

Query: 68   SDENYKDPTNL-QGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLME 126
             D+      +L    +  H+ F+ E+   +G +  L  +G  +I      +  ++ +L E
Sbjct: 5230 EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 5289

Query: 127  LHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVM-DWINDKEAIVTSE-ELGQDLEHV 184
            L  +W+ + +    K  +L QA K  +  R+   ++ +W+++ E  +     L  D E +
Sbjct: 5290 LSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEAL 5349

Query: 185  EVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPE-EELIKTKQDEVNAAWQRLKGL 243
            + L    +EF   +      VN        ++   HP+    IK     + A ++ +   
Sbjct: 5350 QSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTW 5409

Query: 244  ALQRQGKLFGAAEVQRFNRDV-DETISWIKEKEQLMASDD---FGRDLASVQALLRKHEG 299
            A Q Q +L  A      N ++ +E ++WI+  E  +   D     +++  V+AL+ +H+ 
Sbjct: 5410 AKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQT 5469

Query: 300  LERDLAALEDKVKALCAEADR---------------------LQQSHP-----LSATQIQ 333
               ++   +  V  +     R                     L Q  P     LS ++ +
Sbjct: 5470 FMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAK 5529

Query: 334  VKR-EELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASD 392
              R  +L   W+Q+  LA ER  +LND+      L +F +    V   K +   +   S 
Sbjct: 5530 NPRINQLSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSR 5589

Query: 393  VAGAEALLDRHQEHK 407
            V      +D+ Q+ K
Sbjct: 5590 VMDFFRRIDKDQDGK 5604


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  258 bits (658), Expect = 7e-68
 Identities = 473/2464 (19%), Positives = 982/2464 (39%), Gaps = 250/2464 (10%)

Query: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSY-RFQFFQRDAEELEKWIQEK--LQI 66
            + AE+ ++ ++++  R+ R  E++  R+++LE+S      FQ    +L  W+ EK  +  
Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 2534

Query: 67   ASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMIS---EGHFASETIRTR 123
                   DP  L  + Q+ Q    E +A      +L+E    +++   +   ++  ++  
Sbjct: 2535 VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKE 2594

Query: 124  LMELHRQWELLLEKMREKG-------IKLLQAQKLVQYLRE-CEDVMDWINDKEAIVTSE 175
            L  ++++W  L +K+  +        +K  Q Q+L+Q L E    V   ++ + AI T  
Sbjct: 2595 LQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQP 2654

Query: 176  E-LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVN 234
            E + Q LE    ++   E+   ++   +   +E++     LI EQ+ ++EL K + + V 
Sbjct: 2655 EAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV----LIGEQYLKDEL-KKRLETVA 2709

Query: 235  AAWQRLKGLALQRQGKLFGA-AEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQA 292
               Q L+ LA  R  +L  A A  Q+F +  DE  +W+ +K+   A +      L  +Q+
Sbjct: 2710 LPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQS 2769

Query: 293  LLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ--IQVKREELITNWEQIRTLA 350
             L+++E  ++ L       + + AE + L  S P    +  +Q +  EL  +WE++    
Sbjct: 2770 QLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKT 2829

Query: 351  AERHARLNDSY-RLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGE 409
            A+R +RL D   + Q++     DL  W+ + KA ++   +  D    E+ L R +    E
Sbjct: 2830 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE 2889

Query: 410  IDAHEDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDL 469
            ++      +  + +   L+ +     D +R++   +++   A+ E  + +    E+    
Sbjct: 2890 VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMT-- 2947

Query: 470  QLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEF 529
            Q      E   N   K E      ++ D+L S     K  E     L AQ+E + AL+  
Sbjct: 2948 QRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE----KLRAQQEVLQALEPQ 3003

Query: 530  ATKLIQNNHYAMEDVATRRDA--LLSRRNALHERAMRRRAQL-ADSFHLQQFFRDSDELK 586
               L       +ED     DA  LL +     +  +  + ++ +    ++       +  
Sbjct: 3004 VDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFH 3063

Query: 587  SWVNEKMKTATD---------EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQK 637
              V E      D            +D  +LQ +++  + F  ++   +  I+A E     
Sbjct: 3064 CRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA---- 3119

Query: 638  LIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEV 697
              +  H  ++E      +++ L K+ LEA   +  KL E  + +Q     E +EL L  V
Sbjct: 3120 --ECRHMLEEEGTL---DLLGL-KRELEALNKQCGKLTERGKARQ-----EQLELTLGRV 3168

Query: 698  EGHLASDDYGKDLTNVQNLQKKHAL-----LEADVAAHQ---------DRIDGITIQARQ 743
            E          D T     ++  AL      E ++   Q         +++D + ++ +Q
Sbjct: 3169 EDFYRKLKGLNDATTAA--EEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ 3226

Query: 744  FQDAGH---------FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRD-V 793
                G           D + ++   E + AR+  L + +  R  +L ++L     F+D +
Sbjct: 3227 VNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDAL 3286

Query: 794  EDEETWIREKEPIAASTNR-GKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVE 852
            E   +W+ + E + A+      +   V+  +++ + LQ  +   +  +  +  +G  + +
Sbjct: 3287 EPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQ 3346

Query: 853  EGHFA-AEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ-AQQYFADANEAESWMREKE 910
                A  E +  +L  L  +W  L +KA+ R++ LED L  A+Q+   A     ++   E
Sbjct: 3347 SAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE 3406

Query: 911  P-IVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK 969
              +  S   G      +  + +H+AL  D+  + + +    +  QS     +P +     
Sbjct: 3407 KKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3466

Query: 970  ELVLALY----DYQEKSPREVTMKKG----------DILTLLNSTNKDWWKVEVNDRQGF 1015
            E + +L     + Q++  R+  +             D + +LN      W  EV D+   
Sbjct: 3467 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLN------WLAEVEDK--- 3517

Query: 1016 VPAAYVKKLDPAQSASRENLLEEQGS--IALRQEQIDNQTRITKEAGSVSLRMKQ----- 1068
            + + +VK         ++++L  Q +  +AL +E ++ +  + +   +    +KQ     
Sbjct: 3518 LSSVFVKDF-------KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEE 3570

Query: 1069 ----------VEELYHSLLELGEKRKGMLEKSCKKFMLFREA-NELQQWINEKEAAL-TS 1116
                      ++  Y  +     K    LE++ +    F+    EL  W+ E E  L TS
Sbjct: 3571 VLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS 3630

Query: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
                   EQ+   Q++  + +K++  +   L  +N+V+  L         ++ V      
Sbjct: 3631 GGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL---------LELV------ 3675

Query: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSA-HEV 1235
                          PW++   +   V+      + NE+++ +     +R   + +A    
Sbjct: 3676 --------------PWRAREGLDKLVS------DANEQYKLVSDTIGQRVDEIDAAIQRS 3715

Query: 1236 QRFHRDADETKEWIEE---KNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSL 1292
            Q++ + AD    W+ E   K  AL       D  + Q   +K   F  D+    D ++ L
Sbjct: 3716 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK--AFSIDIIRHKDSMDEL 3773

Query: 1293 GETAERLIQSHPESAED-LQEKCTELNQAWSSLGKRADQRKAKLGDSHDL-QRFLSDFRD 1350
                  +  +  E  +  LQEK   L Q + ++     +R A+L  +  L  +F   + +
Sbjct: 3774 FSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE 3833

Query: 1351 LMSWINGIRGLVSS--------DELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFG 1402
            L  WI   R L++         ++L +       L E   EH+  ID          + G
Sbjct: 3834 LSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLL-------KIG 3886

Query: 1403 QQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCL----ELQLFHRDCEQAE 1458
             QL          +++K    +   A +++   QR + LD+ +    ++  FH   E   
Sbjct: 3887 PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPML 3946

Query: 1459 NWMAAREAFLNTEDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHY 1517
              +    + L       + +D +   I  ++     +   +    AL+   ++LI     
Sbjct: 3947 ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006

Query: 1518 AKGDISSRR-NEVLDR----WRRLKAQMIEKRSK-LGESQTLQQFSRDVDEIEAWISEKL 1571
            A  D++++   + LD+    W  +KA+  E+  K L   +  ++F  D+  +   I +  
Sbjct: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQ 4066

Query: 1572 QTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE 1631
                D    +   I  S +  + +  +  + E     + +  +  +G  LI   AC  +E
Sbjct: 4067 DIVHD---LESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIF--ACGETE 4121

Query: 1632 DA-VKARLAALADQWQFLVQKSAEKSQKLKEANKQ--QNFNTGIKDFDFWLSEVEALLAS 1688
               V+  +  + + W+ L +   E+ +KL++A +   Q  +T    FD+  + V  L   
Sbjct: 4122 KPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTM 4181

Query: 1689 EDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQ--VKDKRDT 1746
               G DL +V + L + +  + ++   +  ++ LN Q + ++  +  +T +  +++    
Sbjct: 4182 PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTE 4241

Query: 1747 INGRFQKIKSMAASRRAKLNESH-RLHQFFRDMDDEESWIKE-KKLLVGSEDYGRDLTGV 1804
            +   ++ +    A R+ KL  +   L QF   +++  SW+   ++LL        D   +
Sbjct: 4242 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4301

Query: 1805 QNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNT-IGKEEIQQRLAQFVEHWKELKQL 1863
            +    KH  L+ ++ AH+  ++ V   G +L + +       ++ RL    + W+ + Q 
Sbjct: 4302 EVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQK 4361

Query: 1864 AAARGQRLEESLEYQQ-FVANVEEEEAWINE-KMTLVASEDYGDTLAAIQGLLKKHEAFE 1921
               R Q+L+ +L+  Q F + +E+    +   +  L AS+  G      +  L  H    
Sbjct: 4362 TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4421

Query: 1922 TDFTVHKDRVNDVCTNGQDLI--KKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE 1979
            +     ++  N +   G+ ++  + ++         +  L  K   +     +RK+KL+E
Sbjct: 4422 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4481

Query: 1980 N-SAFLQFNWKADVVESWIGEKENSLK-TDDYGRDLSSVQTLLTKQETFDAGLQAFQQEG 2037
              +   +F        +W+   E SL         L++V + + + + F   + A + + 
Sbjct: 4482 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQ- 4540

Query: 2038 IANITALKDQLLAAKHVQSKA-IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2096
            I  +    +QL      Q    I+    S+  RW +++  S  R + L +A+   ++  +
Sbjct: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHE 4600

Query: 2097 LFLTFAKKASAFNSWFENAEEDLTDPVRC-NSLEEIKALREAHDAFRSSLSSAQADFNQL 2155
             +            W E+AE  L   +   N  ++IK     H  F+ +L   Q  ++  
Sbjct: 4601 AWKKLI-------DWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTT 4653

Query: 2156 AELDRQIKSFRVA---SNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLR 2212
                R +K   +    S     F  E + + W  +     ER       Q + EE     
Sbjct: 4654 IRTGRALKEKTLLPEDSQKLDNFLGE-VRDKWDTVCGKSVER-------QHKLEEALLFS 4705

Query: 2213 QEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIED 2272
             +F     A   W+ +    L +   +  +   + + ++A K   +E+      ++ ++ 
Sbjct: 4706 GQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKR 4765

Query: 2273 LGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQA----RNTTGVTEE 2328
             G  + E    D  + +     L+ +WD + +L +  Q  LEQ ++     R+T  +  E
Sbjct: 4766 SGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLE 4825

Query: 2329 ALKE 2332
             L E
Sbjct: 4826 WLSE 4829



 Score =  250 bits (639), Expect = 1e-65
 Identities = 420/2047 (20%), Positives = 846/2047 (41%), Gaps = 198/2047 (9%)

Query: 3    PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
            P G    +     +  +Q+ L+   R      +   KLE   +F    R+       + +
Sbjct: 3019 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3078

Query: 63   KLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLD------ETGNLMISEGHFA 116
            +L        +D  +LQ +++  + F  ++      ++KLD      E  +++  EG   
Sbjct: 3079 ELD-GMGAIGRDTDSLQSQIEDVRLFLNKIH-----VLKLDIEASEAECRHMLEEEGTLD 3132

Query: 117  SETIRTRLMELHRQWELLLE--KMREKGIKLL--QAQKLVQYLRECEDVMDWINDKEAIV 172
               ++  L  L++Q   L E  K R++ ++L   + +   + L+   D      + EA+ 
Sbjct: 3133 LLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEAL- 3191

Query: 173  TSEELGQDLEHVEVLQKKFEEFQTDMAAH-EERVNEVNQFAAKLIQEQHPEEEL--IKTK 229
                +G ++E +      F+ FQ +     + ++ +VN     LIQ    + ++  ++  
Sbjct: 3192 -QWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD 3250

Query: 230  QDEVNAAWQRLKGLALQRQGKLFGAA-EVQRFNRDVDETISWIKEKEQLMASDDF-GRDL 287
             +E+NA W  L     QR  +L  A     +F   ++  +SW+ + E+L+A+      + 
Sbjct: 3251 MEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEY 3310

Query: 288  ASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQ-IQVKREELITNWEQI 346
              V+A +++ + L+R L   +  V  L AE  R+ QS  L+  + I  + E L + W ++
Sbjct: 3311 KVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTEL 3370

Query: 347  RTLAAERHARLNDSYRLQRF-------LADFRDLTSWVTEMKALINADELASDVAGAEAL 399
             + AA R  +L D   L +        ++DF  +T      K L N++ + +  A  +  
Sbjct: 3371 LSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTE-----KKLANSEPVGTQTAKIQQQ 3425

Query: 400  LDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEV-REKLTVLSEERAALLELWEL 458
            + RH+  + +I+ H      A + GQ+L +    A   V  EK+  L    + + +    
Sbjct: 3426 IIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCR 3485

Query: 459  RRQQYEQCM-DLQLFYRDTEQVDNWMSKQEAFL------------LNEDLGDSLDSVEAL 505
            +    +Q + + +LF  D  +V NW+++ E  L            L+    D L   E +
Sbjct: 3486 KAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEI 3545

Query: 506  LKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATR-RDALLSRRNALHERAMR 564
            + + ++ ++++   +  +         LIQ     ++ + TR  D  ++   AL  R + 
Sbjct: 3546 VNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK---LDGIKTRYADITVTSSKAL--RTLE 3600

Query: 565  RRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKV--QKHQAFEAELS 622
            +  QLA  F         +EL  W+ E  +       + P+  Q     Q+ +  + E+ 
Sbjct: 3601 QARQLATKFQSTY-----EELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVM 3655

Query: 623  ANQSRIDALEKAGQKLIDVNHY-AKDEVAARMNEVISLWKKLLEATELKGIKLREANQQQ 681
             ++  +D + +  + L+++  + A++ +   +++    +K + +    +  ++  A Q+ 
Sbjct: 3656 EHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS 3715

Query: 682  QFNRNVEDIEL-WLYEVEGHLASDD---YGKDLTNVQNLQKKHALLEADVAAHQDRIDGI 737
            Q      D EL W+ E +  L +       +D T  Q LQ + A    D+  H+D +D +
Sbjct: 3716 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ-LQVQKAF-SIDIIRHKDSMDEL 3773

Query: 738  -TIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS-LRLQQLFRDVED 795
             + ++  F   G      +++K E+L+ +YEA+      R  +L  + + + Q +   E+
Sbjct: 3774 FSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE 3833

Query: 796  EETWIREKEPIAAST-NRGKDLIGVQNLLKKHQALQAEIAGHEPRI----------KAVT 844
               WI E   + A   +   D   ++   ++ + L+  IA H+P I          K + 
Sbjct: 3834 LSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN 3893

Query: 845  QKGNAMVEEGHFAAEDVKAKL-HELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAE 903
             +   MVEE +  AE++ A++  E+ Q+  AL    SQ  Q  E   + +          
Sbjct: 3894 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLS 3953

Query: 904  SWMREKEPIVGSTDYGK----DEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQ 959
            S +R    I    D  +    D  SA   L+K +     L   G   + L  ++Q   + 
Sbjct: 3954 SRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRG---EELIGRSQGADKD 4010

Query: 960  VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE-----VNDRQG 1014
            +A  + +   + ++  ++  +    E  +K  D+L L     K W+ +      + D Q 
Sbjct: 4011 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLEL---AEKFWYDMAALLTTIKDTQD 4067

Query: 1015 FVPAAYVKKLDPA----QSASRENLLEEQGSIALRQEQIDNQTRIT----------KEAG 1060
             V       +DP+    Q  + E + EE   +    E I    RI            E  
Sbjct: 4068 IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFI----RILGADLIFACGETEKP 4123

Query: 1061 SVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQ-QWINEKEAAL-TSEE 1118
             V   + ++   + +L +  ++R   LE + +  + +++  +    W++     L T   
Sbjct: 4124 EVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPP 4183

Query: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGM 1178
            VG DL  V+    +  +F+ ++   +  ++ +N   E      LM ++            
Sbjct: 4184 VGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE------LMLKKAT---------- 4227

Query: 1179 MPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQR 1237
               DETD                      + EL   W +L +++A  + +L G+   + +
Sbjct: 4228 ---DETDRDIIR---------------EPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4269

Query: 1238 FHRDADETKEWIEEKNQALNTDN-YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETA 1296
            F    +E   W+    + L+       D   ++    KH   + D+ A    V ++ +  
Sbjct: 4270 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4329

Query: 1297 ERLIQSHP-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSW 1354
              L++S   + A  L+ +   +NQ W S+ ++ ++R+ +L  +    Q F S+  D +  
Sbjct: 4330 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLE 4389

Query: 1355 INGIRGLVSSDELAKDVTG-AEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAH--GHY 1411
            +  +   +S+ +    +   A   L+ H E  +++ A+  T+      G+ +L       
Sbjct: 4390 LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSG 4449

Query: 1412 ASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQL-FHRDCEQAENWMAAREAFLNT 1470
            +  + +Q + +L+Q+   +     +R+  L++ L L   F    ++  NW+   E  LN 
Sbjct: 4450 SGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 4509

Query: 1471 EDKGDS-LDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRN-- 1527
                   L++V + I++H+ F   +N   ++I  L    +QL       K D+   +N  
Sbjct: 4510 ASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQ--KQDVVLIKNLL 4567

Query: 1528 -EVLDRWRRLKAQMIEKRSKLGESQT-LQQFSRDVDEIEAWI--SEKLQTASDESYKDPT 1583
              V  RW ++  + IE+   L +++   +QF     ++  W+  +E    +  E   DP 
Sbjct: 4568 VSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPD 4627

Query: 1584 NIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALAD 1643
             I+L   LSKH++   F+  L          I  G +L E+         +   L  + D
Sbjct: 4628 KIKLQ--LSKHKE---FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRD 4682

Query: 1644 QWQFLVQKSAEKSQKLKEANK-QQNFNTGIKDFDFWLSEVEALLASED--YGKDLASVNN 1700
            +W  +  KS E+  KL+EA      F   ++    WL +VE  LA +   +G DL  V N
Sbjct: 4683 KWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMN 4741

Query: 1701 LLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAAS 1760
            L+  H++ + ++      ++ L      L+ +S  DT+ VK +   ++ R+  +  ++ S
Sbjct: 4742 LMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVS 4801

Query: 1761 RRAKLNESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL 1818
            ++++L ++ +  + FRD +     W+ E ++ L        D   +Q+L   HK    ++
Sbjct: 4802 KQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKV 4861

Query: 1819 AAHEPAIQGVLDTGKKL-----SDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEE 1873
                  +   +  G+ +      D  T  K  I    A+F    +E+   A    QRLE 
Sbjct: 4862 EEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARF----EEVLTWAKQHQQRLET 4917

Query: 1874 SLEYQQFVAN---VEEEEAWINEKMTLVASED---YGDTLAAIQGLLKKHEAFETDFTVH 1927
            +L   + VAN   +EE  AWI    T +   D       +  ++ L+ +H+ F  + T  
Sbjct: 4918 AL--SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRK 4975

Query: 1928 KDRVNDV 1934
            +  V+ V
Sbjct: 4976 QPDVDRV 4982



 Score =  191 bits (486), Expect = 6e-48
 Identities = 467/2555 (18%), Positives = 973/2555 (38%), Gaps = 354/2555 (13%)

Query: 7    KVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI 66
            ++L +++ I +    +  RY     L+T   + + D+ R        EE EK ++E+ Q 
Sbjct: 1373 RMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALR------RLEEEEKVVEEEKQE 1426

Query: 67   ----------------------ASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDE 104
                                  A+    K+ T+++  + + Q    E+      + +  +
Sbjct: 1427 HVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIK 1486

Query: 105  TGNLMISE-GHFASETIRTRLME----------------LHRQWELLLEKMREKGIKLLQ 147
            T  + +++ GH  SE  + ++ E                 ++  +L  +   +   K LQ
Sbjct: 1487 TSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQ 1546

Query: 148  AQKLVQYLRECEDVMDWINDKEAIVTSEE---LGQDLEHVEVLQKKFEEFQTDMAAH--- 201
             Q+   + ++ ED+  W+   E  +   +     QDL  ++  Q   ++ Q D+      
Sbjct: 1547 KQQNTCH-QQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATS 1605

Query: 202  ------------EERVNEVNQFAAKLIQEQ-HPEEELIKTKQDEVNAAWQRLKGL---AL 245
                        EE   +++      ++E+ H  +E  +  Q+E   A + L+     AL
Sbjct: 1606 FATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSAL 1665

Query: 246  QRQGKLFGAA-EVQRFNRDVDETISWIKE--------------KEQLMASDDFGRDLASV 290
            Q++ +   AA E+    + +D  + W+                 EQL  +      L + 
Sbjct: 1666 QQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTT 1725

Query: 291  QALL---RKHEGLERDLAALEDKVKALCAEADRL------------QQSHPLSATQIQVK 335
               +   +  E L++    ++ + + L ++                Q  H L+  + Q+ 
Sbjct: 1726 DGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML 1785

Query: 336  REELITNWEQIRTLAAERHARLNDSY----RLQRFLADFRDLTSWVTEM-KALINADELA 390
            +++L    EQ  T  A+  A L         LQ+FL D ++  SW+    K L N  +  
Sbjct: 1786 QQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGG 1845

Query: 391  SDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALL-------------AAGHYASDE 437
            S      +LL R      ++ +H+   +    SGQ +L               G+   D+
Sbjct: 1846 SSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK 1905

Query: 438  VR---EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAF---LL 491
            ++   E+ T L  +   L     +   QY Q      F    + +  WM   EA    LL
Sbjct: 1906 LKDATERYTALHSKCTRLGSHLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLL 1959

Query: 492  NEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED---VATRR 548
            ++ +      ++  L   +  ++ L+  +  +  L + A  +++       D   V    
Sbjct: 1960 SDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETT 2019

Query: 549  DALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQ 608
            D++LS   +L      R + L  +    Q  ++S  L+S +    +   +   K  S+L 
Sbjct: 2020 DSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES--LESLLQSIGEVEQNLEGKQVSSLS 2077

Query: 609  -GKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAA-----RMNEVISLWKK 662
             G +Q+  A   +L  + +R  +  +A ++++       D   A     ++ EV   +++
Sbjct: 2078 SGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQ 2137

Query: 663  LLEATELKGIKLREA-NQQQQFNRNVEDIELWLYEVEGHLASDDY-GKDLTNV-QNLQKK 719
            L    + K   L++   Q + F      ++ ++      LAS +   +D+T+  Q +Q+ 
Sbjct: 2138 LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQE- 2196

Query: 720  HALLEADVAAHQDRIDGITIQARQFQDAG-------HFD-AENIKKKQEALVARYEALKE 771
               L  ++   Q+ +D +     +    G       H D  +N++K    L    +  ++
Sbjct: 2197 ---LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK 2253

Query: 772  PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831
               + +++L +  +L + F      + W++E E     T        ++  ++  ++L  
Sbjct: 2254 DASSCQEQLDEFRKLVRTF------QKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLD 2307

Query: 832  EIAGHEPRIKAVTQKGNAMVE----------------------------EGHFAAED--- 860
            + A     ++ +  KG ++                               G+   +D   
Sbjct: 2308 DWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTE 2367

Query: 861  VKAKLHELNQKWEALKAKASQRRQDLEDSL-QAQQYFADANEAESWMREKEPIVGSTDYG 919
            ++  + ++N K+E L     +R++ L+  L + ++   +AN    W+  KE ++ S D  
Sbjct: 2368 IQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAM 2427

Query: 920  KDEDSAE---ALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976
                  E   A  + ++A +++L      IQ ++E                   L   L 
Sbjct: 2428 SSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEA------------------LAGLLV 2469

Query: 977  DYQEKSPREVTMKKGDILTLLNSTNKDWWKVEV-NDRQGFVPAAYVKKLDPAQSASRENL 1035
             Y      E   K   I   LNS  +   +V V   RQ    A+++     A+S  R  L
Sbjct: 2470 TYPNSQEAENWKK---IQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL 2526

Query: 1036 LEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFM 1095
            +E++  + +      +   +  +   V   +K+ E       +L E  +G+L       +
Sbjct: 2527 MEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSL 2586

Query: 1096 LFREANELQQWINEKEAALTSE--EVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKV 1153
               +  +  Q IN+K   LT +     + ++Q  V   ++ +  +DL       + +  V
Sbjct: 2587 STSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLS------EKVRAV 2640

Query: 1154 AEDLESEGLMAEEVQAVQQQ-----EVYGMMPRDETDSKTASPW-KSARLMVHTVATFNS 1207
             + L  +  ++ + +AV+QQ     E+   + + + + K A        +++      + 
Sbjct: 2641 GQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 2700

Query: 1208 IKELNER----WRSLQQLAEER-SQLLGSAHEVQRFHRDADETKEWIEEK-NQALNTDNY 1261
            +K+  E      + L+ LA +R ++L  +    Q+F +  DE + W+++K +Q       
Sbjct: 2701 LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI 2760

Query: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP--ESAEDLQEKCTELNQ 1319
               L  +Q+  +++E F++ L         +    E L+ S P  E    LQ +  EL  
Sbjct: 2761 SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN 2820

Query: 1320 AWSSLGKRADQRKAKLGDS-HDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALL 1378
             W  L K+   R+++L D     Q++     DL+ WI   +  +S   +  D    E+ L
Sbjct: 2821 HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL 2880

Query: 1379 ERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRR 1438
             R +    E++ R    +        L+                 D++    EKA + + 
Sbjct: 2881 LRSKAMLNEVEKRRSLLEILNSAADILINSSE------------ADEDGIRDEKAGINQN 2928

Query: 1439 M-MLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDS-------LDSVEALIKKHEDF 1490
            M  + + L+ +    + E  +     +E+F N E K +         D++ +    +++ 
Sbjct: 2929 MDAVTEELQAKTGSLE-EMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNL 2987

Query: 1491 DKAINVQEEKIAALQAFADQL--IAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLG 1548
            +K +  Q+E + AL+   D L     G        S  +++L +    + + +E + ++ 
Sbjct: 2988 EK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVN 3046

Query: 1549 ES-------------------QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSK 1589
                                 +   Q +   DE++   +    T S +S  +   + L+K
Sbjct: 3047 SGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNK 3106

Query: 1590 LLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLV 1649
            +       +A EAE     +   G +D+     E  A       +  R  A  +Q +  +
Sbjct: 3107 IHVLKLDIEASEAECRHMLEE-EGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTL 3165

Query: 1650 QKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLE 1709
             +  +  +KLK          G+ D      E EAL      G ++  +N  L   ++ +
Sbjct: 3166 GRVEDFYRKLK----------GLNDATTAAEEAEAL--QWVVGTEVEIINQQLADFKMFQ 3213

Query: 1710 AD-ISAHEDRLKDLNSQADSLMTSSA--FDTSQVKDKRDTINGRFQKIKSMAASRRAKLN 1766
             + +   + +L+ +N     L+ S+    D   ++   + IN R+  +    A R A+L 
Sbjct: 3214 KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQ 3273

Query: 1767 ESHRLHQFFRD-MDDEESWIKE-KKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPA 1824
            E+      F+D ++   SW+ + ++L+   +    +   V+   ++ K L+  L   +  
Sbjct: 3274 EALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT 3333

Query: 1825 IQGVLDTGKKLSDDNTIG-KEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEY-QQFVA 1882
            +  +   G +++    +  +E+I  +L      W EL   AAAR ++LE+ L   +QF  
Sbjct: 3334 VDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHE 3393

Query: 1883 NVEEEEAWIN-EKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDL 1941
              E    +++  +  L  SE  G   A IQ  + +H+A E D   H   V+     GQ L
Sbjct: 3394 TAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSL 3453

Query: 1942 IKKNNHHEENI-SSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADV-VESWIGE 1999
                +  E+ + S K+  L  + S+++    ++ A LD+  +  +   + +V V +W+ E
Sbjct: 3454 SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAE 3513

Query: 2000 KENSLKT---DDYGRDL---SSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKH 2053
             E+ L +    D+ +D+        L   +E  +        + I N  AL  Q    + 
Sbjct: 3514 VEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNV--DQAIKNGQALLKQTTGEEV 3571

Query: 2054 VQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFE 2113
            +    I+ +   +  R++ +   S+   + L +A+        L   F         W  
Sbjct: 3572 L---LIQEKLDGIKTRYADITVTSSKALRTLEQAR-------QLATKFQSTYEELTGWLR 3621

Query: 2114 NAEEDL-TDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPY 2172
              EE+L T   +  + E+I   ++     +  +   +   + + E+ R +          
Sbjct: 3622 EVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLEL------V 3675

Query: 2173 TWFTMEALE-------ETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW 2225
             W   E L+       E ++ +   I +R  E+    +R        Q++ Q A+A   W
Sbjct: 3676 PWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRS-------QQYEQAADAELAW 3728

Query: 2226 IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKI-----EDLGAAMEEA 2280
            + ET+  L+    +  E     +QL+  K    +I   +  + ++     E  G   EE 
Sbjct: 3729 VAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEE- 3787

Query: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQ 2315
                    +  T  L QQ++ +  L       LE+
Sbjct: 3788 ---QKTVLQEKTESLIQQYEAISLLNSERYARLER 3819



 Score =  168 bits (425), Expect = 7e-41
 Identities = 331/1803 (18%), Positives = 726/1803 (40%), Gaps = 216/1803 (11%)

Query: 9    LETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRF-QFFQRDAEELEKWIQ--EKLQ 65
            L   E I  + + +  R+      +  R+++LED     + F   AE +  ++   EK  
Sbjct: 3350 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3409

Query: 66   IASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLM 125
              S+        +Q ++ +H+A E +++ ++  + +  + G  + S    A + + +  +
Sbjct: 3410 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3469

Query: 126  E-LHRQWELLLEKMREKGIKLLQAQKLVQYLRECE-DVMDW---INDKEAIVTSEELGQD 180
            + L  ++  + ++   K   L QA    +   E E +V++W   + DK + V  ++  QD
Sbjct: 3470 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 3529

Query: 181  LEHVEVLQKKFEEFQTDMAAHEERVNE-------VNQFAAKLIQEQHPEEELIKTKQDEV 233
            + H         +    +A +EE VN        +    A L Q    E  LI+ K D +
Sbjct: 3530 VLH--------RQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGI 3581

Query: 234  NAAWQRLKGLALQRQGKLFGAAEVQ-RFNRDVDETISWIKE-KEQLMASDDFGRDLASVQ 291
               +  +   + +    L  A ++  +F    +E   W++E +E+L  S         + 
Sbjct: 3582 KTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIP 3641

Query: 292  ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
               ++ + L++++      +  +   +  L +  P  A +     ++L+++  +   L +
Sbjct: 3642 QFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE---GLDKLVSDANEQYKLVS 3698

Query: 352  ERHARLNDSY-----RLQRFLADFRDLTSWVTEMKALINA--------DELASDVAGAEA 398
            +   +  D       R Q++        +WV E K  + A        D+  + +   +A
Sbjct: 3699 DTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKA 3758

Query: 399  L---LDRHQEHKGEIDAHEDS-FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLE 454
                + RH++   E+ +H    F +  E  + +L     +  +  E +++L+ ER A LE
Sbjct: 3759 FSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE 3818

Query: 455  LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEK 514
              ++   Q         F+   E++  W+ +  A +    L       E L ++ E+  +
Sbjct: 3819 RAQVLVNQ---------FWETYEELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQ 3867

Query: 515  ---SLSAQEEKITALDEFATKLIQNNHYAMEDVATR----RDALLSRRNALHERAMRRRA 567
               S++  +  I  L +   +L + N    E V  +     +     +  + +RA+    
Sbjct: 3868 LRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDE 3927

Query: 568  QLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDP------SNLQGKVQKHQAFEAEL 621
             ++ S  + +F    D+++  + E ++  +      P        ++  +  +++   EL
Sbjct: 3928 AVSQSTQITEFH---DKIEPML-ETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVEL 3983

Query: 622  SANQSRIDALEKAGQKLIDVNHYAKDEVAAR-----MNEVISLWKKLLEATELKGIKLRE 676
               Q   +AL++ G++LI  +  A  ++AA+     +++++  W+          IK R 
Sbjct: 3984 EKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWED---------IKARA 4034

Query: 677  ANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTN------------VQNLQKKHALLE 724
              ++ +F   +E  E + Y++   L +    +D+ +             Q ++    + E
Sbjct: 4035 EEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094

Query: 725  ADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSL 784
                 H++      + A      G  +   ++K  + +   +E L +    R +KL D++
Sbjct: 4095 ETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAM 4154

Query: 785  RLQQLFRD-VEDEETWIREKE-PIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKA 842
            +    ++D ++    W+      +      G DL  V++ L + +  + E+   +  ++ 
Sbjct: 4155 QAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEK 4214

Query: 843  VTQKGNAMVEEGHFAAED--VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADA- 899
            +  +G  M+++     +   ++  L EL   WE L  K + R+  LE +L A   F  A 
Sbjct: 4215 LNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHAL 4274

Query: 900  NEAESWMREKEPIVGST-DYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQ 958
             E  SW+   E ++ +      D    E  L KH  L +D+ A+ ++++ + +      +
Sbjct: 4275 EELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLE 4334

Query: 959  QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVE---------- 1008
              A  D  + +  + A+    E   ++   ++  + + L        ++E          
Sbjct: 4335 SSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRME 4394

Query: 1009 ----VNDRQGFVPAAYVKKLDP-----AQSASRE---NLLEEQGSIALRQEQIDNQTRIT 1056
                 +   G +P    ++LD      +Q  ++E   N L ++G + L     D+    +
Sbjct: 4395 SQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSR--DDSGSGS 4452

Query: 1057 KEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTS 1116
            K   SV+L    +E+ +H +    E+RK  LE++      F+  N LQ++IN    A  S
Sbjct: 4453 KTEQSVAL----LEQKWHVVSSKMEERKSKLEEALNLATEFQ--NSLQEFINWLTLAEQS 4506

Query: 1117 EEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVY 1176
              + +    +                       +N V   +E   + A EV A + Q + 
Sbjct: 4507 LNIASPPSLI-----------------------LNTVLSQIEEHKVFANEVNAHRDQII- 4542

Query: 1177 GMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHE-V 1235
                  E D +T +  K        V   N +  +  RW  + Q + ER + L  A +  
Sbjct: 4543 ------ELD-QTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 4595

Query: 1236 QRFHRDADETKEWIEEKNQALNTD-NYGHDLASVQALQRKHEGFERDLAALGDKVNSLGE 1294
            ++FH    +  +W+E+    L+++    +D   ++    KH+ F++ L       ++   
Sbjct: 4596 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655

Query: 1295 TAERLIQSH--PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQ-RFLSDFRDL 1351
            T   L +    PE ++ L     E+   W ++  ++ +R+ KL ++     +F+   + L
Sbjct: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715

Query: 1352 MSWINGIRGLVSSDE-LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGH 1410
            + W+  +   ++ D+ +  D+     L++ H+  + E+  R GT Q  ++ G++L+ +  
Sbjct: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR