Search of human proteins with 194440660

Search of human proteins with 194440660

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo
sapiens]
         (1522 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo sapi...  3064   0.0  
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...   128   4e-29
gi|188219549 ankyrin repeat domain 32 [Homo sapiens]                   79   4e-14
gi|93141033 PAX interacting protein 1 [Homo sapiens]                   70   2e-11
gi|122891872 microcephalin [Homo sapiens]                              60   2e-08
gi|190684675 X-ray repair cross complementing protein 1 [Homo sa...    45   5e-04
gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo...    43   0.002
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]     39   0.029
gi|38044112 restin isoform b [Homo sapiens]                            39   0.038
gi|4506751 restin isoform a [Homo sapiens]                             39   0.038
gi|150170670 piccolo isoform 2 [Homo sapiens]                          39   0.038
gi|150378539 piccolo isoform 1 [Homo sapiens]                          39   0.038
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    39   0.050
gi|84043967 REV1-like isoform 2 [Homo sapiens]                         38   0.085
gi|7706681 REV1-like isoform 1 [Homo sapiens]                          38   0.085
gi|109255230 centrosomal protein 170kDa isoform beta [Homo sapiens]    37   0.19 
gi|109255228 centrosomal protein 170kDa isoform alpha [Homo sapi...    37   0.19 
gi|109255232 centrosomal protein 170kDa isoform gamma [Homo sapi...    37   0.19 
gi|36029914 valosin containing protein (p97)/p47 complex interac...    35   0.55 
gi|110347568 centrosomal protein 152kDa [Homo sapiens]                 35   0.55 
gi|53692193 Scm-like with four mbt domains 1 [Homo sapiens]            35   0.55 
gi|53692191 Scm-like with four mbt domains 1 [Homo sapiens]            35   0.55 
gi|53692195 Scm-like with four mbt domains 1 [Homo sapiens]            35   0.55 
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    35   0.72 
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit...    35   0.72 
gi|112382237 desmuslin isoform A [Homo sapiens]                        34   0.94 
gi|8923243 palmdelphin [Homo sapiens]                                  34   1.2  
gi|71774083 myc proto-oncogene protein [Homo sapiens]                  33   1.6  
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    33   1.6  
gi|161016767 mucin 21 [Homo sapiens]                                   33   1.6  

>gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo sapiens]
          Length = 1522

 Score = 3064 bits (7944), Expect = 0.0
 Identities = 1522/1522 (100%), Positives = 1522/1522 (100%)

Query: 1    MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC 60
            MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC
Sbjct: 1    MSRNDKEPFFVKFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYIC 60

Query: 61   DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK 120
            DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK
Sbjct: 61   DPFSGVVFDHLKKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEK 120

Query: 121  REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ 180
            REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ
Sbjct: 121  REEVHKYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQ 180

Query: 181  EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH 240
            EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH
Sbjct: 181  EKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTH 240

Query: 241  LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT 300
            LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT
Sbjct: 241  LIVQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPT 300

Query: 301  SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD 360
            SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD
Sbjct: 301  SQINTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLENLENLDVSAFQAPEDLLD 360

Query: 361  GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH 420
            GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH
Sbjct: 361  GCRIYLCGFSGRKLDKLRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRPH 420

Query: 421  VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS 480
            VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS
Sbjct: 421  VVGAKWLLECFSKGYMLSEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPS 480

Query: 481  EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC 540
            EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC
Sbjct: 481  EKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSVSHC 540

Query: 541  VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG 600
            VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG
Sbjct: 541  VPDVSTITEEGLFSQKSFLVLGFSNENESNIANIIKENAGKIMSLLSRTVADYAVVPLLG 600

Query: 601  CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE 660
            CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE
Sbjct: 601  CEVEATVGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAE 660

Query: 661  KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW 720
            KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW
Sbjct: 661  KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAW 720

Query: 721  LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP 780
            LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP
Sbjct: 721  LLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTP 780

Query: 781  LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK 840
            LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK
Sbjct: 781  LDMNRFQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVK 840

Query: 841  DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE 900
            DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE
Sbjct: 841  DALAALETPGRPSQQKRKPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEE 900

Query: 901  APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS 960
            APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS
Sbjct: 901  APKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYKS 960

Query: 961  VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS 1020
            VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS
Sbjct: 961  VKERGVHIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSS 1020

Query: 1021 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS 1080
            TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS
Sbjct: 1021 TKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMS 1080

Query: 1081 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN 1140
            ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN
Sbjct: 1081 ATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQN 1140

Query: 1141 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC 1200
            EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC
Sbjct: 1141 EQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVC 1200

Query: 1201 DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET 1260
            DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET
Sbjct: 1201 DPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEET 1260

Query: 1261 HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA 1320
            HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA
Sbjct: 1261 HEELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLA 1320

Query: 1321 SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK 1380
            SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK
Sbjct: 1321 SVAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKK 1380

Query: 1381 IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD 1440
            IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD
Sbjct: 1381 IQQRQESGIVEGAFSGWKVILHVDQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD 1440

Query: 1441 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG 1500
            LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG
Sbjct: 1441 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQESPPHVENYCLPEAISFIQNNKELG 1500

Query: 1501 TGLSQKRKAPTEKNKIKRPRVH 1522
            TGLSQKRKAPTEKNKIKRPRVH
Sbjct: 1501 TGLSQKRKAPTEKNKIKRPRVH 1522


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score =  128 bits (322), Expect = 4e-29
 Identities = 87/300 (29%), Positives = 149/300 (49%), Gaps = 28/300 (9%)

Query: 12  KFLKSSDNSKCFFKALESIKEFQSEEYLQIITEEEALKIKENDRSLYICDPFSGVVFDHL 71
           + +K+  + K  F  +ES++EF+  +  +               ++++   F   VF+ L
Sbjct: 64  ELIKALKDIKVGFVKMESVEEFEGLDSPEF-------------ENVFVVTDFQDSVFNDL 110

Query: 72  KKLGCRIVGPQVVIFCMHHQRCVPRAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQM- 130
            K  CR++GP VV+ C      +P +  P+Y   M ++ +  T   K  +EE+ + V + 
Sbjct: 111 YKADCRVIGPPVVLNCSQKGEPLPFSCRPLYCTSMMNLVLCFTGFRK--KEELVRLVTLV 168

Query: 131 --MGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKITRYT 188
             MGG + +D N  VTHL+A     +K+ VA +L  PI+ P WI   WE+  E+      
Sbjct: 169 HHMGGVIRKDFNSKVTHLVANCTQGEKFRVAVSLGTPIMKPEWIYKAWERRNEQDFYAAV 228

Query: 189 DINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQE--P 246
           D    +FK P F  CI+   G    ++  ++++T   GG+Y+  L    CTHL+V+E   
Sbjct: 229 DDFRNEFKVPPFQDCILSFLGFSDEEKTNMEEMTEMQGGKYL-PLGDERCTHLVVEENIV 287

Query: 247 KGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEP--RPEAK---TMPNSSTPTS 301
           K   +E +K+  ++ V  +WF+ SI+      E++Y  E    PE K   +M + +TP S
Sbjct: 288 KDLPFEPSKK--LYVVKQEWFWGSIQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNS 345



 Score = 35.4 bits (80), Expect = 0.42
 Identities = 35/140 (25%), Positives = 59/140 (42%), Gaps = 15/140 (10%)

Query: 645 PLEDCVISFSQCAGAEKESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKER--GG 702
           P +DC++SF   +  EK ++  +  + G               G    THL+++E     
Sbjct: 239 PFQDCILSFLGFSDEEKTNMEEMTEMQGGKY---------LPLGDERCTHLVVEENIVKD 289

Query: 703 SKYEAAKKWNLPAVTIAWLLETARTGKRADESHFLIE--NSTKEERSLETEITNGINLNS 760
             +E +KK  L  V   W   + +   RA E+ +L E  N+ + ++S+     N  N N 
Sbjct: 290 LPFEPSKK--LYVVKQEWFWGSIQMDARAGETMYLYEKANTPELKKSVSMLSLNTPNSNR 347

Query: 761 DTAEHPGTRLQTHRKTVVTP 780
                  T  Q  R+T V+P
Sbjct: 348 KRRRLKETLAQLSRETDVSP 367


>gi|188219549 ankyrin repeat domain 32 [Homo sapiens]
          Length = 1058

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 57/216 (26%), Positives = 102/216 (47%), Gaps = 19/216 (8%)

Query: 1262 EELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLAS 1321
            E+   ++I Q++    +E+     L+ KL    I+ + +   CTH++     ++EK+LA+
Sbjct: 2    EDGTPKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYK-NCTHLIAERLCKSEKFLAA 60

Query: 1322 VAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKI 1381
             AAGKW+L + Y+     +G ++ E  YEWG     D      +Q      A  RWR+++
Sbjct: 61   CAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQS-----APKRWREEL 115

Query: 1382 QQRQESGIVEGAFSGWKVILHV-DQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD 1440
            ++        GAF  WKV+L V    R     R+L++G A V+   S P     TH+ + 
Sbjct: 116  KRTG----APGAFHRWKVVLLVRTDKRSDSLIRVLEAGKANVILPKSSP--SGITHVIAS 169

Query: 1441 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQE 1476
              ++K +    N              +Y+ D+L+++
Sbjct: 170  NARIKAEKEKDNF------KAPFYPIQYLGDFLLEK 199


>gi|93141033 PAX interacting protein 1 [Homo sapiens]
          Length = 1069

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 75/324 (23%), Positives = 136/324 (41%), Gaps = 14/324 (4%)

Query: 126 KYVQMMGGRVYRDLNVSVTHLIAGEVGSKKYLVAANLKKPILLPSWIKTLWEKSQEKKIT 185
           + +Q  GG V        THL+     S  Y  A   +K  +   W+ T+ +K  +K + 
Sbjct: 631 RIIQAHGGTVDPTFTSRCTHLLCESQVSSAYAQAIRERKRCVTAHWLNTVLKK--KKMVP 688

Query: 186 RYTDINMEDFKCPIFLGC---IICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLI 242
            +  ++      P    C   II VTG    DR +++ +    G +Y G L  +  T LI
Sbjct: 689 PHRALHFPVAFPPGGKPCSQHIISVTGFVDSDRDDLKLMAYLAGAKYTGYLCRSN-TVLI 747

Query: 243 VQEPKGQKYECAKRWNVHCVTTQWFFDSIEKGFCQDESIYKTEPRPEAKTMPNSSTPTSQ 302
            +EP G KYE AK W + CV  QW  D +   F     I  +     +   P + T    
Sbjct: 748 CKEPTGLKYEKAKEWRIPCVNAQWLGDILLGNFEALRQIQYSRYTAFSLQDPFAPTQHLV 807

Query: 303 INTIDSRTLSDVSNISNINASCVSESICNSLNSKLEPTLE--NLENLDVSAFQAPEDLLD 360
           +N +D+  +    +   + +  +   +  +  + ++P+ +   +E++     +   +L  
Sbjct: 808 LNLLDAWRVPLKVSAELLMSIRLPPKLKQNEVANVQPSSKRARIEDVPPPTKKLTPELTP 867

Query: 361 GCRIYLCGFSGRKLDK-LRRLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRP 419
              +   GF   ++ + +++L   GG V   +  +  TH+I       +K F    +   
Sbjct: 868 --FVLFTGFEPVQVQQYIKKLYILGGEVA--ESAQKCTHLIASKVTRTVK-FLTAISVVK 922

Query: 420 HVVGAKWLLECFSKGYMLSEEPYI 443
           H+V  +WL ECF     + E+ YI
Sbjct: 923 HIVTPEWLEECFRCQKFIDEQNYI 946



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 41/120 (34%), Positives = 63/120 (52%), Gaps = 9/120 (7%)

Query: 165 PILLPSWIKTLWEKSQEKKITRYTDINMEDFKCPIFLGCIICVTGLCGLDRKEVQQLTVK 224
           P++ PSW+    +      +  ++  +     C IF G   C++ +   DR  +  L   
Sbjct: 69  PVVKPSWVILSVQCGTLLPVNGFSPES-----CQIFFGITACLSQVSSEDRSALWALVTF 123

Query: 225 HGGQYMGQLKMNE-CTHLIVQEPKGQKYECA-KRWNVHCVTTQWFFDSIEKGFCQDESIY 282
           +GG    QL +N+ CTHLIV EPKG+KYECA KR ++  VT  W  D + +   +DE+ Y
Sbjct: 124 YGGDC--QLTLNKKCTHLIVPEPKGEKYECALKRASIKIVTPDWVLDCVSEKTKKDEAFY 181



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 36/111 (32%), Positives = 50/111 (45%), Gaps = 10/111 (9%)

Query: 611 VTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISFSQCAGAEKESLTFLANL 670
           VT  WL T +  + +  P    L  PV    G  P    +IS +    ++++ L  +A L
Sbjct: 672 VTAHWLNTVLKKKKMVPPH-RALHFPVAFPPGGKPCSQHIISVTGFVDSDRDDLKLMAYL 730

Query: 671 LGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPAVTIAWL 721
            GA    Y  R         ++T LI KE  G KYE AK+W +P V   WL
Sbjct: 731 AGAKYTGYLCR---------SNTVLICKEPTGLKYEKAKEWRIPCVNAQWL 772



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 40/190 (21%), Positives = 83/190 (43%), Gaps = 28/190 (14%)

Query: 908  VVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHFIYQGRPNDTNREYK-SVKERGV 966
            +  C+S+  S+ +S L  +    G D + + ++  TH I    P     +Y+ ++K   +
Sbjct: 102  ITACLSQVSSEDRSALWALVTFYGGDCQLTLNKKCTHLIV---PEPKGEKYECALKRASI 158

Query: 967  HIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEP 1026
             IV+  W+LDC  E     E+     Y+P++                ++      +++E 
Sbjct: 159  KIVTPDWVLDCVSEKTKKDEAF----YHPRL----------------IIYEEEEEEEEEE 198

Query: 1027 DPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIM-SATSIV 1085
            + +  EE D  N  + +++S+P++    + S     Q    + N +K   E+M   +S  
Sbjct: 199  EEVENEEQDSQNEGSTDEKSSPASSQEGSPSG---DQQFSPKSNTEKSKGELMFDDSSDS 255

Query: 1086 KPQGQRTSLS 1095
             P+ Q  +L+
Sbjct: 256  SPEKQERNLN 265



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 54/219 (24%), Positives = 91/219 (41%), Gaps = 39/219 (17%)

Query: 550 EGLFSQKSFLVLGFSNENESNIANIIKENAGKIMS---LLSRTVADYAVVPLLGCEVEAT 606
           E +F +  +  +G   + +  +  ++K    K +S   L S  +++    P +G   E  
Sbjct: 10  EEMFREVKYYAVG---DIDPQVIQLLKAGKAKEVSYNALASHIISEDGDNPEVGEAREVF 66

Query: 607 VGEVVTNTWLVTCIDYQTLFDPKSNPLFTPVPVMTGMTPLEDCVISF------SQCAGAE 660
              VV  +W++  +   TL           +PV  G +P E C I F      SQ +  +
Sbjct: 67  DLPVVKPSWVILSVQCGTL-----------LPV-NGFSP-ESCQIFFGITACLSQVSSED 113

Query: 661 KESLTFLANLLGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAA-KKWNLPAVTIA 719
           + +L  L    G   Q    +K          THLI+ E  G KYE A K+ ++  VT  
Sbjct: 114 RSALWALVTFYGGDCQLTLNKKC---------THLIVPEPKGEKYECALKRASIKIVTPD 164

Query: 720 WLLETARTGKRADESHF----LIENSTKEERSLETEITN 754
           W+L+      + DE+ +    +I    +EE   E E+ N
Sbjct: 165 WVLDCVSEKTKKDEAFYHPRLIIYEEEEEEEEEEEEVEN 203



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 20/77 (25%), Positives = 35/77 (45%), Gaps = 3/77 (3%)

Query: 1273 SSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLASVAAGKWVLHRS 1332
            +   P +   Y   +  LGG V E       CTH++     R  K+L +++  K ++   
Sbjct: 872  TGFEPVQVQQYIKKLYILGGEVAESA---QKCTHLIASKVTRTVKFLTAISVVKHIVTPE 928

Query: 1333 YLEACRTAGHFVQEEDY 1349
            +LE C     F+ E++Y
Sbjct: 929  WLEECFRCQKFIDEQNY 945



 Score = 32.3 bits (72), Expect = 3.6
 Identities = 27/99 (27%), Positives = 40/99 (40%), Gaps = 6/99 (6%)

Query: 78  IVGPQVVIFCMHHQRCVP-RAEHPVYNMVMSDVTISCTSLEKEKREEVHKYVQMMGGRVY 136
           +V P  VI  +     +P     P    +   +T   + +  E R  +   V   GG   
Sbjct: 70  VVKPSWVILSVQCGTLLPVNGFSPESCQIFFGITACLSQVSSEDRSALWALVTFYGGDCQ 129

Query: 137 RDLNVSVTHLIAGEVGSKKY---LVAANLKKPILLPSWI 172
             LN   THLI  E   +KY   L  A++K  I+ P W+
Sbjct: 130 LTLNKKCTHLIVPEPKGEKYECALKRASIK--IVTPDWV 166



 Score = 31.2 bits (69), Expect = 8.0
 Identities = 19/61 (31%), Positives = 33/61 (54%), Gaps = 2/61 (3%)

Query: 114 TSLEKEKREEVHKYVQMMGGRVYRDLNVSVTHLIAGEVG-SKKYLVAANLKKPILLPSWI 172
           T  E  + ++  K + ++GG V        THLIA +V  + K+L A ++ K I+ P W+
Sbjct: 872 TGFEPVQVQQYIKKLYILGGEVAESAQ-KCTHLIASKVTRTVKFLTAISVVKHIVTPEWL 930

Query: 173 K 173
           +
Sbjct: 931 E 931


>gi|122891872 microcephalin [Homo sapiens]
          Length = 835

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 156/763 (20%), Positives = 289/763 (37%), Gaps = 123/763 (16%)

Query: 658  GAEKESLTFLANL--LGASVQEYFVRKSNAKKGMFASTHLILKERGGSKYEAAKKWNLPA 715
            G E  S TF   L  +GA V + F ++          TH+I K+   S ++ A+K  +  
Sbjct: 20   GTENYSKTFTTQLVDMGAKVSKTFNKQV---------THVIFKDGYQSTWDKAQKRGVKL 70

Query: 716  VTIAWLLETARTGKRADESHFLIENSTKEERSL---ETEITNGINLNSDTAEH------- 765
            V++ W+ +    G   DES F   N  +   SL   + +     + N  T E+       
Sbjct: 71   VSVLWVEKCRTAGAHIDESLFPAANMNEHLSSLIKKKRKCMQPKDFNFKTPENDKRFQKK 130

Query: 766  -------------------PGTRLQTHRKTVVTP-LDMNRFQSKAF-RAVVSQHARQVAA 804
                               P    +++   + TP +++N     A  + +     ++   
Sbjct: 131  FEKMAKELQRQKTNLDDDVPILLFESNGSLIYTPTIEINSSHHSAMEKRLQEMKEKRENL 190

Query: 805  SPAVGQPLQKE---PSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPS---QQKRK 858
            SP   Q +Q+    PS  L      +S+D L    +      ++ +     S    Q+RK
Sbjct: 191  SPTSSQMIQQSHDNPSNSLCEAPLNISRDTLCSDEYFAGGLHSSFDDLCGNSGCGNQERK 250

Query: 859  PSTPL----SEVIVKNLQLALAN--SSRNAVALS-ASPQLKEAQSEKEEAPKPLHKVVVC 911
                +    S+V + +L L   N  SS +   L  +SPQ   +   KEE     +     
Sbjct: 251  LEGSINDIKSDVCISSLVLKANNIHSSPSFTHLDKSSPQKFLSNLSKEEINLQRN----I 306

Query: 912  VSKKLSKKQSELNGIAASLGAD-YRWS--FDETVTHFIYQGRPNDTNREYKSVKERGVHI 968
              K ++  Q +  G++     + YR S     T  H +   RP  ++ + K V   G H 
Sbjct: 307  AGKVVTPDQKQAAGMSQETFEEKYRLSPTLSSTKGHLLIHSRPRSSSVKRKRVSH-GSHS 365

Query: 969  VSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRL--LSAVSSTKDDEP 1026
              +       ++CK    +    +  P++ L  S  +   +    L  LS   S+ DD  
Sbjct: 366  PPK-------EKCKRKRSTR--RSIMPRLQLCRSEDRLQHVAGPALEALSCGESSYDDYF 416

Query: 1027 DPLILEENDVDNMATNNK-ESAPSNGSGKNDSKGVLTQTLEMREN--FQKQLQEI----M 1079
             P  L+E   +N+   ++  S+P+  S ++ SK   T   EM +     K+ + +     
Sbjct: 417  SPDNLKERYSENLPPESQLPSSPAQLSCRSLSKKERTSIFEMSDFSCVGKKTRTVDITNF 476

Query: 1080 SATSIVKPQGQRTSLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQ 1139
            +A +I  P+       R+  +  +S P+             EALR  RQ   +       
Sbjct: 477  TAKTISSPRKTGNGEGRATSSCVTSAPE-------------EALRCCRQAGKE------- 516

Query: 1140 NEQIIWDDPTAREERARLASNLQWPSCPTQYSE----LQVDIQNLEDSPFQKPLHDS-EI 1194
                      A  E    +  ++ P+ P  + +    L+  ++ ++++   K   +    
Sbjct: 517  ---------DACPEGNGFSYTIEDPALPKGHDDDLTPLEGSLEEMKEAVGLKSTQNKGTT 567

Query: 1195 AKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKI 1254
            +K +    G  +    P   +   +ET  ++   +P   + S+        V     +  
Sbjct: 568  SKISNSSEGEAQSEHEPCFIVDCNMETSTEEKENLPGGYSGSVKNRPTRHDVLDDSCDGF 627

Query: 1255 ITIEETHEELKKQ-------YIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHI 1307
              + + HEELKK            ++S+  +++     +++KL G  I     + T TH+
Sbjct: 628  KDLIKPHEELKKSGRGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETT-THV 686

Query: 1308 VVGHPLRNEKYLASVAAGKWVLHRSYLEACRTAGHFVQEEDYE 1350
            + G PLR    L  +A G WVL   ++      GH++ EE +E
Sbjct: 687  LSGKPLRTLNVLLGIARGCWVLSYDWVLWSLELGHWISEEPFE 729



 Score = 39.3 bits (90), Expect = 0.029
 Identities = 39/160 (24%), Positives = 68/160 (42%), Gaps = 30/160 (18%)

Query: 379 RLINSGGGVRFNQLNEDVTHVIVGDYDDELKQFWNKSAHRP-HVVGAKWLLECFSKGYML 437
           +L++ G  V     N+ VTHVI   + D  +  W+K+  R   +V   W+ +C + G  +
Sbjct: 31  QLVDMGAKVS-KTFNKQVTHVI---FKDGYQSTWDKAQKRGVKLVSVLWVEKCRTAGAHI 86

Query: 438 SEEPYIHANYQPVEIPVSHKPESKAALLKKKNSSFSKKDFAPSEKHEQADEDLLSQYENG 497
            E  +          P ++  E  ++L+KKK      KDF  + K  + D+    ++E  
Sbjct: 87  DESLF----------PAANMNEHLSSLIKKKRKCMQPKDF--NFKTPENDKRFQKKFEKM 134

Query: 498 SSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEENQSSV 537
           +  +   KT+             L+D   I L E N S +
Sbjct: 135 AKELQRQKTN-------------LDDDVPILLFESNGSLI 161


>gi|190684675 X-ray repair cross complementing protein 1 [Homo
           sapiens]
          Length = 633

 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 43/156 (27%), Positives = 64/156 (41%), Gaps = 23/156 (14%)

Query: 847 ETPGRPSQQ-----KRKPS------TPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQ 895
           +TP +P  Q      ++P       TP +  +    Q A+    R         + +  +
Sbjct: 256 KTPSKPPAQLSPSVPKRPKLPAPTRTPATAPVPARAQGAVTGKPRGE-----GTEPRRPR 310

Query: 896 SEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYR--WSFDETVTHFIYQGRPND 953
           +  EE  K L  VVV +S   +  +SEL   A  LGA YR  W+ D T     +   P  
Sbjct: 311 AGPEELGKILQGVVVVLSGFQNPFRSELRDKALELGAKYRPDWTRDSTHLICAFANTP-- 368

Query: 954 TNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLY 989
              +Y  V   G  IV + W+LDC +  + LP   Y
Sbjct: 369 ---KYSQVLGLGGRIVRKEWVLDCHRMRRRLPSQRY 401


>gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo
           sapiens]
          Length = 1014

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 61/302 (20%), Positives = 116/302 (38%), Gaps = 26/302 (8%)

Query: 706 EAAKKWNLPAVTIAWLLETARTGKRADESHFLIENSTKEERSLETEITNGINLNSDTAEH 765
           EA KK  LP V      E  R G   D    + +  +K+E+  ++++   +   +D   +
Sbjct: 193 EALKK-QLPGVKS----EGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWN 247

Query: 766 PGTRLQTHRKTVVTPLDMNR---FQSKAFRAVVSQHARQVAASPAVGQPLQKEPSLHLDT 822
               ++   K V +  D+     F  +   +  S    +VA     G  L  E     + 
Sbjct: 248 ----IKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCE-----EC 298

Query: 823 PSKFLSKDKLFKPSFDVK---DALAALETPGRP---SQQKRKPSTPLSEVIVKNLQLALA 876
             + + K   +  + DV      +   +TP R    + ++ +  + L ++ VK       
Sbjct: 299 SGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFP 358

Query: 877 NSSRNAVALSASPQLKEAQS---EKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGAD 933
             +  +VA +  P    A +       A KPL  + +    KLS+ + E+  +   LG  
Sbjct: 359 PETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGK 418

Query: 934 YRWSFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLDCAQECKHLPESLYPHTY 993
              + ++       +      N++ + VKE  + +VSE +L D +   K L E    H  
Sbjct: 419 LTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHIL 478

Query: 994 NP 995
           +P
Sbjct: 479 SP 480


>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
          Length = 3664

 Score = 39.3 bits (90), Expect = 0.029
 Identities = 21/76 (27%), Positives = 39/76 (51%), Gaps = 3/76 (3%)

Query: 1190 HDSEIAKQAVCDPGNIRV---TEAPKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPV 1246
            H + +++Q     G ++V   ++AP+ P  E  +TP   +   PTP    +  PL  P  
Sbjct: 3202 HVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAP 3261

Query: 1247 APHPREKIITIEETHE 1262
            APH   +I+T+  +++
Sbjct: 3262 APHGEARILTVTPSNQ 3277


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 38.9 bits (89), Expect = 0.038
 Identities = 63/289 (21%), Positives = 114/289 (39%), Gaps = 52/289 (17%)

Query: 821  DTPSKFLSKDKLFKPSFDVKDALA-----ALETPGRPSQQ--KRKPSTPLSEVIVKNLQL 873
            D  +KF  KD+  +     K+ L       ++  G  S Q  K      L E  V+ LQL
Sbjct: 858  DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 917

Query: 874  ALANSSRNA---------VALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELN 924
             L  ++ NA         + + A    +EA  + EE  K L + +  + KK+    ++  
Sbjct: 918  KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 977

Query: 925  GIAASLGADYRWSFDETVTHF--IYQGRPN---DTNREYKSVKERGVHIVSEHWLL---- 975
                 L A Y  +  ET T    I Q       DT  + K  +E    ++ E   L    
Sbjct: 978  ----ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA 1033

Query: 976  DCAQECKHLPESLYPHTYNPKMSLD-ISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEEN 1034
            D A+  +   +++       K   + +++++D +  N++L                  +N
Sbjct: 1034 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKL------------------QN 1075

Query: 1035 DVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATS 1083
            ++D +  NN +    N    N SK +LT   +  E F+K+++ +  A +
Sbjct: 1076 ELDTLKENNLK----NVEELNKSKELLTVENQKMEEFRKEIETLKQAAA 1120


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 38.9 bits (89), Expect = 0.038
 Identities = 63/289 (21%), Positives = 114/289 (39%), Gaps = 52/289 (17%)

Query: 821  DTPSKFLSKDKLFKPSFDVKDALA-----ALETPGRPSQQ--KRKPSTPLSEVIVKNLQL 873
            D  +KF  KD+  +     K+ L       ++  G  S Q  K      L E  V+ LQL
Sbjct: 893  DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 952

Query: 874  ALANSSRNA---------VALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLSKKQSELN 924
             L  ++ NA         + + A    +EA  + EE  K L + +  + KK+    ++  
Sbjct: 953  KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 1012

Query: 925  GIAASLGADYRWSFDETVTHF--IYQGRPN---DTNREYKSVKERGVHIVSEHWLL---- 975
                 L A Y  +  ET T    I Q       DT  + K  +E    ++ E   L    
Sbjct: 1013 ----ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA 1068

Query: 976  DCAQECKHLPESLYPHTYNPKMSLD-ISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEEN 1034
            D A+  +   +++       K   + +++++D +  N++L                  +N
Sbjct: 1069 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKL------------------QN 1110

Query: 1035 DVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATS 1083
            ++D +  NN +    N    N SK +LT   +  E F+K+++ +  A +
Sbjct: 1111 ELDTLKENNLK----NVEELNKSKELLTVENQKMEEFRKEIETLKQAAA 1155


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 38.9 bits (89), Expect = 0.038
 Identities = 62/314 (19%), Positives = 117/314 (37%), Gaps = 39/314 (12%)

Query: 890  QLKE----AQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHF 945
            QLKE     +S+K+E  K   K+     ++L++K S    I    G  + W  ++     
Sbjct: 1581 QLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSS--TSIDEDAGRRHSWHDEDDEA-- 1636

Query: 946  IYQGRPNDTNREYKSVKERGVHIVSEHWL-------LDCAQECKHLPESLYPHT---YNP 995
             +   P    RE KS +   + +     L       L+     K+  ES    T   ++ 
Sbjct: 1637 -FDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDE 1695

Query: 996  KMSLDISAVQDGRLCNSR-----LLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSN 1050
            +  L++ ++ D     SR      L A S T    P  +   + D D+  ++ K  +   
Sbjct: 1696 EPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQ 1755

Query: 1051 GSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTR 1110
               ++   G L  T+E       + +E+     ++K Q ++  + +    S+S      +
Sbjct: 1756 RKARHRPHGPLLPTIED----SSEEEELREEEELLKEQEKQREIEQQQRKSSS------K 1805

Query: 1111 SARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQY 1170
             ++  +  +    R+ R   P  N  P ++       PT    +A     L   SC    
Sbjct: 1806 KSKKDKDELRAQRRRERPKTPPSNLSPIEDAS-----PTEELRQAAEMEELHRSSCSEYS 1860

Query: 1171 SELQVDIQNLEDSP 1184
              ++ D +  E SP
Sbjct: 1861 PSIESDPEGFEISP 1874


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 38.9 bits (89), Expect = 0.038
 Identities = 62/314 (19%), Positives = 117/314 (37%), Gaps = 39/314 (12%)

Query: 890  QLKE----AQSEKEEAPKPLHKVVVCVSKKLSKKQSELNGIAASLGADYRWSFDETVTHF 945
            QLKE     +S+K+E  K   K+     ++L++K S    I    G  + W  ++     
Sbjct: 1581 QLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSS--TSIDEDAGRRHSWHDEDDEA-- 1636

Query: 946  IYQGRPNDTNREYKSVKERGVHIVSEHWL-------LDCAQECKHLPESLYPHT---YNP 995
             +   P    RE KS +   + +     L       L+     K+  ES    T   ++ 
Sbjct: 1637 -FDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDE 1695

Query: 996  KMSLDISAVQDGRLCNSR-----LLSAVSSTKDDEPDPLILEENDVDNMATNNKESAPSN 1050
            +  L++ ++ D     SR      L A S T    P  +   + D D+  ++ K  +   
Sbjct: 1696 EPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQ 1755

Query: 1051 GSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTR 1110
               ++   G L  T+E       + +E+     ++K Q ++  + +    S+S      +
Sbjct: 1756 RKARHRPHGPLLPTIED----SSEEEELREEEELLKEQEKQREIEQQQRKSSS------K 1805

Query: 1111 SARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQY 1170
             ++  +  +    R+ R   P  N  P ++       PT    +A     L   SC    
Sbjct: 1806 KSKKDKDELRAQRRRERPKTPPSNLSPIEDAS-----PTEELRQAAEMEELHRSSCSEYS 1860

Query: 1171 SELQVDIQNLEDSP 1184
              ++ D +  E SP
Sbjct: 1861 PSIESDPEGFEISP 1874


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 38.5 bits (88), Expect = 0.050
 Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 1/73 (1%)

Query: 1180 LEDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPSIAF 1239
            LE+SP   P  +S ++      P +  + E+P  P  E   +P  ++ L P P+A  ++ 
Sbjct: 489  LEESPLSPPPEESPLSPPPESSPFS-PLEESPLSPPEESPPSPALETPLSPPPEASPLSP 547

Query: 1240 PLANPPVAPHPRE 1252
            P    P++P P E
Sbjct: 548  PFEESPLSPPPEE 560



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 24/101 (23%), Positives = 43/101 (42%), Gaps = 2/101 (1%)

Query: 1181 EDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEE--LETPIKDSHLIPTPQAPSIA 1238
            E+SP   P   S ++      P +    ++P  P  E+  +  P+++S L+P P+ P + 
Sbjct: 676  EESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLC 735

Query: 1239 FPLANPPVAPHPREKIITIEETHEELKKQYIFQLSSLNPQE 1279
                 P ++P P E  ++       L  Q      S  P+E
Sbjct: 736  PRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEE 776



 Score = 34.3 bits (77), Expect = 0.94
 Identities = 25/94 (26%), Positives = 39/94 (41%), Gaps = 13/94 (13%)

Query: 1181 EDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEE-----------LETPIKDSHLI 1229
            EDSP   P  DS  +        ++ + E+P  P+ EE           L    ++ HL 
Sbjct: 694  EDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLS 753

Query: 1230 PTPQAPSIAFPLANPPVAPHPREKIITI--EETH 1261
            P P+ P ++     P ++P P E  +    EE H
Sbjct: 754  PRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPH 787



 Score = 31.6 bits (70), Expect = 6.1
 Identities = 21/79 (26%), Positives = 36/79 (45%), Gaps = 2/79 (2%)

Query: 1181 EDSPFQKPLHDSEIAKQAVCDPGNIRVTEAPKHPISEELET--PIKDSHLIPTPQAPSIA 1238
            E+SP   P   S ++   V    +    E+P  P  EE  T  P + S L P P+    +
Sbjct: 640  EESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTS 699

Query: 1239 FPLANPPVAPHPREKIITI 1257
             P  + P +P P + ++++
Sbjct: 700  PPPEDSPASPPPEDSLMSL 718


>gi|84043967 REV1-like isoform 2 [Homo sapiens]
          Length = 1250

 Score = 37.7 bits (86), Expect = 0.085
 Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 2/76 (2%)

Query: 199 IFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWN 258
           IF G  I V G      +E+++L + HGGQY      ++ TH+I       K +  K   
Sbjct: 48  IFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEK 107

Query: 259 VHCVTTQWFFDSIEKG 274
           V  +  +W  +SI+ G
Sbjct: 108 V--IRPEWIVESIKAG 121



 Score = 34.3 bits (77), Expect = 0.94
 Identities = 25/104 (24%), Positives = 48/104 (46%), Gaps = 8/104 (7%)

Query: 358 LLDGCRIYLCGFSGRKLDKLRRLIN-SGGGVRFNQLNEDVTHVIVGDYDD-ELKQFWNKS 415
           +  G  IY+ G++    ++LR+L+   GG           TH+I  +  + ++K+   + 
Sbjct: 48  IFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEK 107

Query: 416 AHRPHVVGAKWLLECFSKGYMLSEEPY-IHANYQPVEIPVSHKP 458
             RP     +W++E    G +LS  PY ++     V+  +S  P
Sbjct: 108 VIRP-----EWIVESIKAGRLLSYIPYQLYTKQSSVQKGLSFNP 146


>gi|7706681 REV1-like isoform 1 [Homo sapiens]
          Length = 1251

 Score = 37.7 bits (86), Expect = 0.085
 Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 2/76 (2%)

Query: 199 IFLGCIICVTGLCGLDRKEVQQLTVKHGGQYMGQLKMNECTHLIVQEPKGQKYECAKRWN 258
           IF G  I V G      +E+++L + HGGQY      ++ TH+I       K +  K   
Sbjct: 48  IFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEK 107

Query: 259 VHCVTTQWFFDSIEKG 274
           V  +  +W  +SI+ G
Sbjct: 108 V--IRPEWIVESIKAG 121



 Score = 34.3 bits (77), Expect = 0.94
 Identities = 25/104 (24%), Positives = 48/104 (46%), Gaps = 8/104 (7%)

Query: 358 LLDGCRIYLCGFSGRKLDKLRRLIN-SGGGVRFNQLNEDVTHVIVGDYDD-ELKQFWNKS 415
           +  G  IY+ G++    ++LR+L+   GG           TH+I  +  + ++K+   + 
Sbjct: 48  IFSGVAIYVNGYTDPSAEELRKLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKELKGEK 107

Query: 416 AHRPHVVGAKWLLECFSKGYMLSEEPY-IHANYQPVEIPVSHKP 458
             RP     +W++E    G +LS  PY ++     V+  +S  P
Sbjct: 108 VIRP-----EWIVESIKAGRLLSYIPYQLYTKQSSVQKGLSFNP 146


>gi|109255230 centrosomal protein 170kDa isoform beta [Homo sapiens]
          Length = 1486

 Score = 36.6 bits (83), Expect = 0.19
 Identities = 105/518 (20%), Positives = 190/518 (36%), Gaps = 82/518 (15%)

Query: 744  EERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPL------DMNRFQSKAFRAVVSQ 797
            EE+SLE+     +   S+  E   T LQ   K   T +      D +R  SK  RAV  +
Sbjct: 553  EEKSLESHRAKVVTQRSEIGEKQDTELQ--EKETPTQVYQKDKQDADRPLSKMNRAVNGE 610

Query: 798  HARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKR 857
              +    +  +         LHL + +    K +  K +  VK  LA L+   +  Q++ 
Sbjct: 611  TLKTGGDNKTL---------LHLGSSAPGKEKSETDKETSLVKQTLAKLQ---QQEQREE 658

Query: 858  KPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLS 917
               TP +++  KN+               + P  K +     +  +      V  S+   
Sbjct: 659  AQWTP-TKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDR------VAQSESKR 711

Query: 918  KKQSELNGIAASLGADYRWSFDETV---THFIYQGRPNDTNREYKSVKERGVHIVSEHWL 974
            +K  E+       G D + S    V   +  I +  PN        + ++     S    
Sbjct: 712  RKAEEILKSQTPKGGDKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSS-LA 770

Query: 975  LDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEEN 1034
            L  A   +   ESL     +P  S+D + +    L ++  + A    K       + E+N
Sbjct: 771  LTSASRIRERSESL-----DPDSSMDTTLI----LKDTEAVMAFLEAK-------LREDN 814

Query: 1035 DVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSL 1094
              D        +  ++ S ++D     T +L   E  +K  Q+  S TS+ K +      
Sbjct: 815  KTDEGPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDR------ 868

Query: 1095 SRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREER 1154
                C++ S + D T+S+ SG    +E   +SR T  DV +  +   + +      R+  
Sbjct: 869  ----CSTGSPSKDVTKSSSSGAREKMEKKTKSRST--DVGSR-ADGRKFVQSSGRIRQPS 921

Query: 1155 ARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDP-GNIRVTEAPKH 1213
              L  + Q  S P  +S +  DI + +   +              C P G   +T A +H
Sbjct: 922  VDLTDDDQTSSVP--HSAIS-DIMSSDQETYS-------------CKPHGRTPLTSADEH 965

Query: 1214 PISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPR 1251
                 + + ++ S +  +  +P ++   +     P PR
Sbjct: 966  -----VHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR 998


>gi|109255228 centrosomal protein 170kDa isoform alpha [Homo sapiens]
          Length = 1584

 Score = 36.6 bits (83), Expect = 0.19
 Identities = 105/518 (20%), Positives = 190/518 (36%), Gaps = 82/518 (15%)

Query: 744  EERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPL------DMNRFQSKAFRAVVSQ 797
            EE+SLE+     +   S+  E   T LQ   K   T +      D +R  SK  RAV  +
Sbjct: 651  EEKSLESHRAKVVTQRSEIGEKQDTELQ--EKETPTQVYQKDKQDADRPLSKMNRAVNGE 708

Query: 798  HARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKR 857
              +    +  +         LHL + +    K +  K +  VK  LA L+   +  Q++ 
Sbjct: 709  TLKTGGDNKTL---------LHLGSSAPGKEKSETDKETSLVKQTLAKLQ---QQEQREE 756

Query: 858  KPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLS 917
               TP +++  KN+               + P  K +     +  +      V  S+   
Sbjct: 757  AQWTP-TKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDR------VAQSESKR 809

Query: 918  KKQSELNGIAASLGADYRWSFDETV---THFIYQGRPNDTNREYKSVKERGVHIVSEHWL 974
            +K  E+       G D + S    V   +  I +  PN        + ++     S    
Sbjct: 810  RKAEEILKSQTPKGGDKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSS-LA 868

Query: 975  LDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEEN 1034
            L  A   +   ESL     +P  S+D + +    L ++  + A    K       + E+N
Sbjct: 869  LTSASRIRERSESL-----DPDSSMDTTLI----LKDTEAVMAFLEAK-------LREDN 912

Query: 1035 DVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSL 1094
              D        +  ++ S ++D     T +L   E  +K  Q+  S TS+ K +      
Sbjct: 913  KTDEGPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDR------ 966

Query: 1095 SRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREER 1154
                C++ S + D T+S+ SG    +E   +SR T  DV +  +   + +      R+  
Sbjct: 967  ----CSTGSPSKDVTKSSSSGAREKMEKKTKSRST--DVGSR-ADGRKFVQSSGRIRQPS 1019

Query: 1155 ARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDP-GNIRVTEAPKH 1213
              L  + Q  S P  +S +  DI + +   +              C P G   +T A +H
Sbjct: 1020 VDLTDDDQTSSVP--HSAIS-DIMSSDQETYS-------------CKPHGRTPLTSADEH 1063

Query: 1214 PISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPR 1251
                 + + ++ S +  +  +P ++   +     P PR
Sbjct: 1064 -----VHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR 1096


>gi|109255232 centrosomal protein 170kDa isoform gamma [Homo sapiens]
          Length = 1460

 Score = 36.6 bits (83), Expect = 0.19
 Identities = 105/518 (20%), Positives = 190/518 (36%), Gaps = 82/518 (15%)

Query: 744  EERSLETEITNGINLNSDTAEHPGTRLQTHRKTVVTPL------DMNRFQSKAFRAVVSQ 797
            EE+SLE+     +   S+  E   T LQ   K   T +      D +R  SK  RAV  +
Sbjct: 553  EEKSLESHRAKVVTQRSEIGEKQDTELQ--EKETPTQVYQKDKQDADRPLSKMNRAVNGE 610

Query: 798  HARQVAASPAVGQPLQKEPSLHLDTPSKFLSKDKLFKPSFDVKDALAALETPGRPSQQKR 857
              +    +  +         LHL + +    K +  K +  VK  LA L+   +  Q++ 
Sbjct: 611  TLKTGGDNKTL---------LHLGSSAPGKEKSETDKETSLVKQTLAKLQ---QQEQREE 658

Query: 858  KPSTPLSEVIVKNLQLALANSSRNAVALSASPQLKEAQSEKEEAPKPLHKVVVCVSKKLS 917
               TP +++  KN+               + P  K +     +  +      V  S+   
Sbjct: 659  AQWTP-TKLSSKNVSGQTDKCREETFKQESQPPEKNSGHSTSKGDR------VAQSESKR 711

Query: 918  KKQSELNGIAASLGADYRWSFDETV---THFIYQGRPNDTNREYKSVKERGVHIVSEHWL 974
            +K  E+       G D + S    V   +  I +  PN        + ++     S    
Sbjct: 712  RKAEEILKSQTPKGGDKKESSKSLVRQGSFTIEKPSPNIPIELIPHINKQTSSTPSS-LA 770

Query: 975  LDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEEN 1034
            L  A   +   ESL     +P  S+D + +    L ++  + A    K       + E+N
Sbjct: 771  LTSASRIRERSESL-----DPDSSMDTTLI----LKDTEAVMAFLEAK-------LREDN 814

Query: 1035 DVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSL 1094
              D        +  ++ S ++D     T +L   E  +K  Q+  S TS+ K +      
Sbjct: 815  KTDEGPDTPSYNRDNSISPESDVDTASTISLVTGETERKSTQKRKSFTSLYKDR------ 868

Query: 1095 SRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREER 1154
                C++ S + D T+S+ SG    +E   +SR T  DV +  +   + +      R+  
Sbjct: 869  ----CSTGSPSKDVTKSSSSGAREKMEKKTKSRST--DVGSR-ADGRKFVQSSGRIRQPS 921

Query: 1155 ARLASNLQWPSCPTQYSELQVDIQNLEDSPFQKPLHDSEIAKQAVCDP-GNIRVTEAPKH 1213
              L  + Q  S P  +S +  DI + +   +              C P G   +T A +H
Sbjct: 922  VDLTDDDQTSSVP--HSAIS-DIMSSDQETYS-------------CKPHGRTPLTSADEH 965

Query: 1214 PISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPR 1251
                 + + ++ S +  +  +P ++   +     P PR
Sbjct: 966  -----VHSKLEGSKVTKSKTSPVVSGSSSKSTTLPRPR 998


>gi|36029914 valosin containing protein (p97)/p47 complex interacting
            protein 1 [Homo sapiens]
          Length = 1222

 Score = 35.0 bits (79), Expect = 0.55
 Identities = 37/143 (25%), Positives = 65/143 (45%), Gaps = 18/143 (12%)

Query: 1041 TNNKESAPSNGSGKNDSKGVLTQTLEMREN---FQKQLQEIMSATS--IVKPQGQRTSLS 1095
            T ++ES+PS+G  K  S GV+ +  E   N   FQ +   + +A+    + P+ + TS+ 
Sbjct: 992  TRSRESSPSHGLLKLGSGGVVKKKSEQLHNVTAFQGKGHSLGTASGNPHLDPRARETSVV 1051

Query: 1096 RSG------CNSASSTPDSTRSARSGRSRVLE------ALRQSRQTVPD-VNTEPSQNEQ 1142
            R         NS++ T  S  +A S  S ++        +R  RQ  PD V  +  + ++
Sbjct: 1052 RKHNTGTDFSNSSTKTEPSVFTASSSNSELIRIAPGVVTMRDGRQLDPDLVEAQRKKLQE 1111

Query: 1143 IIWDDPTAREERARLASNLQWPS 1165
            ++     + +   R  S  Q PS
Sbjct: 1112 MVSSIQASMDRHLRDQSTEQSPS 1134


>gi|110347568 centrosomal protein 152kDa [Homo sapiens]
          Length = 1654

 Score = 35.0 bits (79), Expect = 0.55
 Identities = 27/111 (24%), Positives = 52/111 (46%), Gaps = 3/111 (2%)

Query: 967  HIVSEHWLLDCAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEP 1026
            H+VS+  L +  ++C    E L+    + K S+++    D        L   SST D   
Sbjct: 562  HLVSQ--LQNDLKDCHKKIEDLHQVKKDEK-SIEVETKTDTSEKPKNQLWPESSTSDVVR 618

Query: 1027 DPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQE 1077
            D ++L +N++  +   N+E   + G  +N ++ +  Q  +M ++F    QE
Sbjct: 619  DDILLLKNEIQVLQQQNQELKETEGKLRNTNQDLCNQMRQMVQDFDHDKQE 669


>gi|53692193 Scm-like with four mbt domains 1 [Homo sapiens]
          Length = 866

 Score = 35.0 bits (79), Expect = 0.55
 Identities = 57/285 (20%), Positives = 104/285 (36%), Gaps = 24/285 (8%)

Query: 919  KQSELNGIAASLGADYRW-SFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLD- 976
            K S  +G    L A Y+  S+  TV       R  +  R+     E   ++     +LD 
Sbjct: 563  KDSVWHGCGEVLKAKYKGKSYRATVEIVKTADRVTEFCRQTCIKLECCPNLFGPRMVLDK 622

Query: 977  CAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDV 1036
            C++ C  L ++ Y H Y  K +  I     G    +  L   S  +    +  + ++   
Sbjct: 623  CSENCSVLTKTKYTHYYGKKKNKRIGRPPGGHSNLACALKKASKRRKRRKNVFVHKKKRS 682

Query: 1037 DNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSR 1096
                 N    +P    G+++         +  E     L E  ++    + Q +     +
Sbjct: 683  SASVDNTPAGSPQGSGGEDED--------DPDEGDDDSLSEGSTSEQQDELQEESEMSEK 734

Query: 1097 SGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERAR 1156
              C+S+ +  + + S    R R    LR    +  D   +P          P+ +E R  
Sbjct: 735  KSCSSSPTQSEISTSLPPDRQRRKRELRTF--SFSDDENKP----------PSPKEIRIE 782

Query: 1157 LASNLQWPSCPTQYSELQV--DIQNLEDSPFQKPLHDSEIAKQAV 1199
            +A  L   S P ++S   V   I++ + +P  +   D EI  QA+
Sbjct: 783  VAERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQAL 827


>gi|53692191 Scm-like with four mbt domains 1 [Homo sapiens]
          Length = 866

 Score = 35.0 bits (79), Expect = 0.55
 Identities = 57/285 (20%), Positives = 104/285 (36%), Gaps = 24/285 (8%)

Query: 919  KQSELNGIAASLGADYRW-SFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLD- 976
            K S  +G    L A Y+  S+  TV       R  +  R+     E   ++     +LD 
Sbjct: 563  KDSVWHGCGEVLKAKYKGKSYRATVEIVKTADRVTEFCRQTCIKLECCPNLFGPRMVLDK 622

Query: 977  CAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDV 1036
            C++ C  L ++ Y H Y  K +  I     G    +  L   S  +    +  + ++   
Sbjct: 623  CSENCSVLTKTKYTHYYGKKKNKRIGRPPGGHSNLACALKKASKRRKRRKNVFVHKKKRS 682

Query: 1037 DNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSR 1096
                 N    +P    G+++         +  E     L E  ++    + Q +     +
Sbjct: 683  SASVDNTPAGSPQGSGGEDED--------DPDEGDDDSLSEGSTSEQQDELQEESEMSEK 734

Query: 1097 SGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERAR 1156
              C+S+ +  + + S    R R    LR    +  D   +P          P+ +E R  
Sbjct: 735  KSCSSSPTQSEISTSLPPDRQRRKRELRTF--SFSDDENKP----------PSPKEIRIE 782

Query: 1157 LASNLQWPSCPTQYSELQV--DIQNLEDSPFQKPLHDSEIAKQAV 1199
            +A  L   S P ++S   V   I++ + +P  +   D EI  QA+
Sbjct: 783  VAERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQAL 827


>gi|53692195 Scm-like with four mbt domains 1 [Homo sapiens]
          Length = 866

 Score = 35.0 bits (79), Expect = 0.55
 Identities = 57/285 (20%), Positives = 104/285 (36%), Gaps = 24/285 (8%)

Query: 919  KQSELNGIAASLGADYRW-SFDETVTHFIYQGRPNDTNREYKSVKERGVHIVSEHWLLD- 976
            K S  +G    L A Y+  S+  TV       R  +  R+     E   ++     +LD 
Sbjct: 563  KDSVWHGCGEVLKAKYKGKSYRATVEIVKTADRVTEFCRQTCIKLECCPNLFGPRMVLDK 622

Query: 977  CAQECKHLPESLYPHTYNPKMSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDV 1036
            C++ C  L ++ Y H Y  K +  I     G    +  L   S  +    +  + ++   
Sbjct: 623  CSENCSVLTKTKYTHYYGKKKNKRIGRPPGGHSNLACALKKASKRRKRRKNVFVHKKKRS 682

Query: 1037 DNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSR 1096
                 N    +P    G+++         +  E     L E  ++    + Q +     +
Sbjct: 683  SASVDNTPAGSPQGSGGEDED--------DPDEGDDDSLSEGSTSEQQDELQEESEMSEK 734

Query: 1097 SGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERAR 1156
              C+S+ +  + + S    R R    LR    +  D   +P          P+ +E R  
Sbjct: 735  KSCSSSPTQSEISTSLPPDRQRRKRELRTF--SFSDDENKP----------PSPKEIRIE 782

Query: 1157 LASNLQWPSCPTQYSELQV--DIQNLEDSPFQKPLHDSEIAKQAV 1199
            +A  L   S P ++S   V   I++ + +P  +   D EI  QA+
Sbjct: 783  VAERLHLDSNPLKWSVADVVRFIRSTDCAPLARIFLDQEIDGQAL 827


>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
            sapiens]
          Length = 1393

 Score = 34.7 bits (78), Expect = 0.72
 Identities = 46/223 (20%), Positives = 81/223 (36%), Gaps = 17/223 (7%)

Query: 1016 SAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQL 1075
            S+  ST+  E  PL   EN   + A   +    +       S    T+  E   N +  L
Sbjct: 416  SSAESTEHGERTPLA-NENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEKTTL 474

Query: 1076 QEIMSATSIVKPQGQRTSLSRSG-CNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVN 1134
              +    +      ++T+ S +    +   TP +     S  +   E     R  + + N
Sbjct: 475  SPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTE--HGERTPLANEN 532

Query: 1135 TEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSP-FQKPLHDSE 1193
            T PS  E      PT   ER         P+ PT+  + +  + N + +P   +P  + +
Sbjct: 533  TTPSPAE------PTENRERTANEKTTPSPAEPTENGD-RTPLANEKTTPSLAEPTENGQ 585

Query: 1194 IAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPS 1236
                A     N + T +   P   E  TP+ + +  P+P  P+
Sbjct: 586  RTPFA-----NEKTTSSSAEPTEHEERTPLANENTTPSPAEPT 623


>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis critical
            region 1 [Homo sapiens]
          Length = 1400

 Score = 34.7 bits (78), Expect = 0.72
 Identities = 46/223 (20%), Positives = 81/223 (36%), Gaps = 17/223 (7%)

Query: 1016 SAVSSTKDDEPDPLILEENDVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQL 1075
            S+  ST+  E  PL   EN   + A   +    +       S    T+  E   N +  L
Sbjct: 478  SSAESTEHGERTPLA-NENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEKTTL 536

Query: 1076 QEIMSATSIVKPQGQRTSLSRSG-CNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVN 1134
              +    +      ++T+ S +    +   TP +     S  +   E     R  + + N
Sbjct: 537  SPVEPTENRETTANEKTTPSPAEPTENGQRTPFANEKTTSSSAEPTE--HGERTPLANEN 594

Query: 1135 TEPSQNEQIIWDDPTAREERARLASNLQWPSCPTQYSELQVDIQNLEDSP-FQKPLHDSE 1193
            T PS  E      PT   ER         P+ PT+  + +  + N + +P   +P  + +
Sbjct: 595  TTPSPAE------PTENRERTANEKTTPSPAEPTENGD-RTPLANEKTTPSLAEPTENGQ 647

Query: 1194 IAKQAVCDPGNIRVTEAPKHPISEELETPIKDSHLIPTPQAPS 1236
                A     N + T +   P   E  TP+ + +  P+P  P+
Sbjct: 648  RTPFA-----NEKTTSSSAEPTEHEERTPLANENTTPSPAEPT 685



 Score = 32.3 bits (72), Expect = 3.6
 Identities = 58/281 (20%), Positives = 100/281 (35%), Gaps = 38/281 (13%)

Query: 1016 SAVSSTKDDEPDPLILEENDVDNMATNNKESAPS-NGSGKNDSKGVLTQTLEMRENFQKQ 1074
            S V+   D    PL    + +D  +T++ ++  S + SG + +K   T   E      K 
Sbjct: 238  STVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAASKT 297

Query: 1075 LQEIMSATSIVKPQGQRTSLSRSGCNSASSTPDSTR------SARSGRSRVLEALRQSRQ 1128
              +    T+    + ++T  SR+   S      +T+      SA      + E      +
Sbjct: 298  TYK----TTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEHGGR 353

Query: 1129 TVPDVNT----EPSQNEQIIWDD--------PTAREERARLASNLQWPSCPTQYSELQVD 1176
            T  + NT    EP++N +   ++        PT   ER    +   +P+ PT+  E+  +
Sbjct: 354  TANENNTPSPAEPTENRERTANENTTLSPAEPTENRERTANENTAPFPAGPTENREMTAN 413

Query: 1177 IQNLEDSPFQKPLHDSEIAKQ----AVCDP-------GNIRVTEAPKHPISEELETPIKD 1225
             +N    P +   H    A +    +  +P        N   T +P  P      TP  +
Sbjct: 414  -ENTTLFPAEPTEHGERTANENTTPSPAEPTEHGERTANENTTPSPAEPTEHGERTPFAN 472

Query: 1226 SHLIPTPQAPS---IAFPLANPPVAPHPREKIITIEETHEE 1263
                 +    +      PLAN    P P E     E T  E
Sbjct: 473  DKTTSSSAESTEHGERTPLANENTTPSPAEPTENRERTANE 513


>gi|112382237 desmuslin isoform A [Homo sapiens]
          Length = 1565

 Score = 34.3 bits (77), Expect = 0.94
 Identities = 45/211 (21%), Positives = 87/211 (41%), Gaps = 27/211 (12%)

Query: 997  MSLDISAVQDGRLCNSRLLSAVSSTKDDEPDPLILEENDVDNMATNNK------------ 1044
            +S+D+  VQ     +  L++ V+ ++  + D L LEE   D  +   K            
Sbjct: 982  VSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELSKDEASEMEKAVESVVRESLSR 1041

Query: 1045 ESAPSNGSGKND------SKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRTSLSRSG 1098
            + +P+ GS   +      + G+  +    RE +      I S  S V      +S  R+ 
Sbjct: 1042 QRSPAPGSPDEEGGAEAPAAGIRFRRWATRELY------IPSGESEVAGGASHSSGQRTP 1095

Query: 1099 CNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPSQNEQIIWDDPTAREERARLA 1158
                S+T + +      +S+VLE + Q+ + +    +E  + E++ ++ PTA        
Sbjct: 1096 QGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERMSYEGPTAEVVEVSAG 1155

Query: 1159 SNLQWPSCPTQYSELQVDIQNLEDSPFQKPL 1189
             +L   + PT  S     ++++   P Q PL
Sbjct: 1156 GDLSQAASPTGASR---SVRHVTLGPGQSPL 1183


>gi|8923243 palmdelphin [Homo sapiens]
          Length = 551

 Score = 33.9 bits (76), Expect = 1.2
 Identities = 22/78 (28%), Positives = 32/78 (41%), Gaps = 7/78 (8%)

Query: 474 KKDFAPSEKHEQADEDLLSQYENGSSTVVEAKTSEARPFNDSTHAEPLNDSTHISLQEEN 533
           K  + P   H Q        Y+    T +  K SEA P  ++ H  P  +S  +  QEE+
Sbjct: 460 KPSYHPIAPHSQV-------YQPAKPTPLPRKRSEASPHENTNHKSPHKNSISLKEQEES 512

Query: 534 QSSVSHCVPDVSTITEEG 551
             S  H  P  +  T +G
Sbjct: 513 LGSPVHHSPFDAQTTGDG 530


>gi|71774083 myc proto-oncogene protein [Homo sapiens]
          Length = 454

 Score = 33.5 bits (75), Expect = 1.6
 Identities = 40/159 (25%), Positives = 67/159 (42%), Gaps = 16/159 (10%)

Query: 978  AQECKHLPESLYPHTYNPKMSLDISAVQDGRL---CNSRLLSAVSSTKDDEPDPLILEEN 1034
            A EC   P  ++P+  N   S    A QD       +  LLS+  S+    P+PL+L E 
Sbjct: 200  ASECID-PSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEE 258

Query: 1035 DVDNMATNNKESAPSNGSGKNDSKGVLTQTLEMRENFQKQLQE-IMSATSIVKPQGQRTS 1093
                 +++++E        + D + +   ++E R+   K+ +    SA    KP      
Sbjct: 259  TPPTTSSDSEEE-------QEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLV 311

Query: 1094 LSRSGCNSAS---STPDSTRSARSGRSRV-LEALRQSRQ 1128
            L R   ++     + P STR       RV L+++R  RQ
Sbjct: 312  LKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQ 350


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
            sapiens]
          Length = 2715

 Score = 33.5 bits (75), Expect = 1.6
 Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 5/65 (7%)

Query: 1211 PKHPISEELETPIKDSHLIPTPQAPSIAFPLANPPVAPHPREKIITIEETHEELKKQYIF 1270
            PK  +S  L  PI  S   P PQ P+   P+ +PP AP P    + + E    + ++  F
Sbjct: 555  PKVEVSPVLRPPITTSP--PVPQEPA---PVPSPPRAPTPPSTPVPLPEKRRSILREPTF 609

Query: 1271 QLSSL 1275
            + +SL
Sbjct: 610  RWTSL 614


>gi|161016767 mucin 21 [Homo sapiens]
          Length = 566

 Score = 33.5 bits (75), Expect = 1.6
 Identities = 28/112 (25%), Positives = 46/112 (41%), Gaps = 13/112 (11%)

Query: 1040 ATNNKESAPSNGSG-------KNDSKGVLTQTLEMRENFQKQLQEIMSATSIVKPQGQRT 1092
            ATN++ S PS+G+G          S G  T T          +  + ++ S     G  T
Sbjct: 240  ATNSESSTPSSGAGTATNSESSTTSSGAGTATNSESSTVSSGISTVTNSESSTPSSGANT 299

Query: 1093 ------SLSRSGCNSASSTPDSTRSARSGRSRVLEALRQSRQTVPDVNTEPS 1138
                  S + SG N+A+++  ST S+ +  +   E+   S       N+E S
Sbjct: 300  ATNSESSTTSSGANTATNSDSSTTSSGASTATNSESSTTSSGASTATNSESS 351


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,043,132
Number of Sequences: 37866
Number of extensions: 2810737
Number of successful extensions: 9621
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 9398
Number of HSP's gapped (non-prelim): 277
length of query: 1522
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1407
effective length of database: 13,892,928
effective search space: 19547349696
effective search space used: 19547349696
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.