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Search of human proteins with 194294523
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
(1670 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 3332 0.0
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 3318 0.0
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 2395 0.0
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 1966 0.0
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 1170 0.0
gi|10864047 epidermal growth factor receptor pathway substrate 1... 151 4e-36
gi|148746195 trichohyalin [Homo sapiens] 131 6e-30
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 127 1e-28
gi|4503593 epidermal growth factor receptor pathway substrate 15... 125 3e-28
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 125 3e-28
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 125 3e-28
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 125 3e-28
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 120 1e-26
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 120 1e-26
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 118 5e-26
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 114 6e-25
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 114 6e-25
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 114 6e-25
gi|194473700 Src homology 3 domain-containing guanine nucleotide... 112 3e-24
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 109 3e-23
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 109 3e-23
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 107 1e-22
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 107 1e-22
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 107 1e-22
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 107 1e-22
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 107 1e-22
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 106 2e-22
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 106 2e-22
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 106 2e-22
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 106 2e-22
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 3332 bits (8640), Expect = 0.0
Identities = 1670/1670 (100%), Positives = 1670/1670 (100%)
Query: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
Query: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
Query: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
Query: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
Query: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
Query: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
Query: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
Query: 601 ALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK 660
ALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK
Sbjct: 601 ALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK 660
Query: 661 LEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLK 720
LEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLK
Sbjct: 661 LEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLK 720
Query: 721 AEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGW 780
AEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGW
Sbjct: 721 AEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGW 780
Query: 781 FPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
FPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL
Sbjct: 781 FPCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
Query: 841 TVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITV 900
TVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITV
Sbjct: 841 TVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITV 900
Query: 901 LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYI 960
LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYI
Sbjct: 901 LEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYI 960
Query: 961 ALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASK 1020
ALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASK
Sbjct: 961 ALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASK 1020
Query: 1021 SGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1080
SGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF
Sbjct: 1021 SGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1080
Query: 1081 PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG 1140
PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG
Sbjct: 1081 PASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQG 1140
Query: 1141 EINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMAD 1200
EINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMAD
Sbjct: 1141 EINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMAD 1200
Query: 1201 LQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMI 1260
LQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMI
Sbjct: 1201 LQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMI 1260
Query: 1261 GDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFL 1320
GDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFL
Sbjct: 1261 GDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFL 1320
Query: 1321 LKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEW 1380
LKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEW
Sbjct: 1321 LKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEW 1380
Query: 1381 IQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQ 1440
IQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQ
Sbjct: 1381 IQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQ 1440
Query: 1441 FAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTD 1500
FAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTD
Sbjct: 1441 FAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTD 1500
Query: 1501 NINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPN 1560
NINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPN
Sbjct: 1501 NINERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPN 1560
Query: 1561 GKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDF 1620
GKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDF
Sbjct: 1561 GKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDF 1620
Query: 1621 LGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLL 1670
LGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLL
Sbjct: 1621 LGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLL 1670
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 3318 bits (8602), Expect = 0.0
Identities = 1670/1697 (98%), Positives = 1670/1697 (98%), Gaps = 27/1697 (1%)
Query: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
Query: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
Query: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
Query: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
Query: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
Query: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
Query: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
Query: 601 ALEKETASKLSEMDSFNNQLK---------------------------ELRETYNTQQLA 633
ALEKETASKLSEMDSFNNQLK ELRETYNTQQLA
Sbjct: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
Query: 634 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 693
LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
Sbjct: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
Query: 694 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 753
EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
Sbjct: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
Query: 754 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 813
GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
Sbjct: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
Query: 814 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 873
TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
Sbjct: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
Query: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 933
LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
Query: 934 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 993
REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
Sbjct: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
Query: 994 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1053
SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
Query: 1054 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1113
LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
Sbjct: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
Query: 1114 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1173
NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
Sbjct: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
Query: 1174 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL 1233
DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL
Sbjct: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL 1260
Query: 1234 IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD 1293
IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD
Sbjct: 1261 IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD 1320
Query: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL
Sbjct: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380
Query: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1413
ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK
Sbjct: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1440
Query: 1414 LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV 1473
LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV
Sbjct: 1441 LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV 1500
Query: 1474 KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA 1533
KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA
Sbjct: 1501 KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA 1560
Query: 1534 RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC 1593
RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC
Sbjct: 1561 RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC 1620
Query: 1594 QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG 1653
QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG
Sbjct: 1621 QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG 1680
Query: 1654 EVWVRFDLQLFEQKTLL 1670
EVWVRFDLQLFEQKTLL
Sbjct: 1681 EVWVRFDLQLFEQKTLL 1697
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 2395 bits (6206), Expect = 0.0
Identities = 1209/1242 (97%), Positives = 1211/1242 (97%), Gaps = 27/1242 (2%)
Query: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
Query: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
Query: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
Query: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
Query: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
Query: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
Query: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
Query: 601 ALEKETASKLSEMDSFNNQ---------------------------LKELRETYNTQQLA 633
ALEKETASKLSEMDSFNNQ LKELRETYNTQQLA
Sbjct: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
Query: 634 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 693
LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
Sbjct: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
Query: 694 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 753
EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
Sbjct: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
Query: 754 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 813
GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
Sbjct: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
Query: 814 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 873
TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
Sbjct: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
Query: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 933
LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
Query: 934 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 993
REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
Sbjct: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
Query: 994 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1053
SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
Query: 1054 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1113
LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
Sbjct: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
Query: 1114 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1173
NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
Sbjct: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
Query: 1174 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAES 1215
DTMQPIERKRQGYIHELIQTEERYMADLQLVVEV + +A S
Sbjct: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVRRLLLASS 1242
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 1966 bits (5093), Expect = 0.0
Identities = 1049/1756 (59%), Positives = 1296/1756 (73%), Gaps = 127/1756 (7%)
Query: 2 MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
MAQFPT G ++WAIT EER KHD+QF +LKP G+ITGDQARNFF QSGLP PVLA+
Sbjct: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
Query: 62 IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP LPP+MKQ P+ A FGMG
Sbjct: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119
Query: 122 MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
+ ++ P+T+++ G+ +P + M LV SV T+++P NG +IQPL
Sbjct: 120 IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169
Query: 179 P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
P + ++TLP SS+S G +QKAQS D+ S +
Sbjct: 170 PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213
Query: 237 EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 214 EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
L AEEFILAMHL D+A +GQPLP LPPE +PPSFR G I I+ T LP
Sbjct: 274 LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333
Query: 349 KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
+++E+ Q KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 394 KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
Query: 467 RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
RQELLNQ+N+EQE+IV L +KKK L ELEALN K Q+ G+LQD+R + TQ+ E+E
Sbjct: 454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP-DSGVSLLHKKS 585
+K +L I EI LQQ+LQE Q L L+PEKQ+LN+++K +Q ++ DS V+L K++
Sbjct: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571
Query: 586 LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDK 644
LE +EL Q L++QLD +EKET SKL E+D FNNQLKELRE +N QQL ++ + +R K
Sbjct: 572 LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLK 631
Query: 645 LKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE--------EKQKRLQEEK 696
KE ERK +EL ++K +EA R+A++ ++ W E++++E+E E++K +EE
Sbjct: 632 QKEQERKIIELEKQK---EEAQRRAQE-RDKQWLEHVQQEDEHQRPRKLHEEEKLKREES 687
Query: 697 TQEKIQEEERKAE----------EKQRKDKDTLKAE----EKKRETASV-----LVNYRA 737
++K EE+ K E + Q K ++A EK T S +V YRA
Sbjct: 688 VKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRA 747
Query: 738 LYPFEARNHDEMSFNSGDIIQV-----DEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSS 792
LYPFE+R+HDE++ GDI+ V DE GEPGWL G +G GWFP NY EK+P +
Sbjct: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
Query: 793 E----------NEKAVSPKKALLPPTVSLSATST-------------SSEPLSSNQPASV 829
E + A +PK AL L+ TS+ S+ P S+N+
Sbjct: 808 EVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPET 867
Query: 830 TDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPGSV-SPIHGQGQVVENLKAQALCSWTAK 885
++ + +LTV ++ Q ++SAFT + GS SP+ GQG+ VE L+AQAL W AK
Sbjct: 868 DNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAK 927
Query: 886 KDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKR--------EEP 937
KDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GWFPKSYVK+I G K E P
Sbjct: 928 KDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESP 987
Query: 938 EALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGD 997
+L + P + GEE+IA+Y Y S E GDLTF +G+ ILVT+KDG+WWTG++GD
Sbjct: 988 ASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGD 1045
Query: 998 RSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILK 1057
++G+FPSNYV+ KD E G+A K+G+ KKPEIAQV ++Y A+G EQL+LAPGQLILI K
Sbjct: 1046 KAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRK 1105
Query: 1058 KNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------VCQVIAMYD 1110
KN GWW+GELQARGKKRQ GWFPA++VKLL P + + TP P VCQVI MYD
Sbjct: 1106 KNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYD 1165
Query: 1111 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADL 1170
Y A N+DEL+F+KGQ+INV+NK+DPDWW+GE+NG GLFPSNYVK+TTD DPSQQWC+DL
Sbjct: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQWCSDL 1225
Query: 1171 QTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNW 1230
LD + P ERKRQGYIHELI TEE Y+ DLQLV E+FQK + ES LTE E+A+IFVNW
Sbjct: 1226 HLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNW 1285
Query: 1231 KELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQ 1290
KELIM N KLLKALRVRKK GEKMPV+MIGDIL+A+L HMQ YIRFCS QLNGAAL+QQ
Sbjct: 1286 KELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQ 1345
Query: 1291 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1350
KTDE DFKEF+K+LA DPRCKGMPLSSF+LKPMQR+TRYPL+I++ILENTPE+H DHS
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
Query: 1351 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLH 1410
LK ALE+AEELCSQVNEGVREKENSDRLEWIQAHVQCEGL+EQL+FNS+TNCLGPRK LH
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLH 1465
Query: 1411 SGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNE 1470
SGKLYK KSNKEL+GFLFNDFLLLT + K SSG++K+FS KSN Q+KMYKTPIFLNE
Sbjct: 1466 SGKLYKAKSNKELYGFLFNDFLLLTQITKPLG-SSGTDKVFSPKSNLQYKMYKTPIFLNE 1524
Query: 1471 VLVKLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKA 1530
VLVKLPTDPS DEP+FHISHIDRVYTLR ++INERTAWVQKIKAASE YI+TEKKKREKA
Sbjct: 1525 VLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASELYIETEKKKREKA 1584
Query: 1531 YQARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWN 1590
Y RSQ+ +GIGRLMV+V+E ELK C+ +GKSNPYCE++MGSQ + T+TIQDTLNPKWN
Sbjct: 1585 YLVRSQRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWN 1644
Query: 1591 FNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEV 1650
NCQFFI+DL Q+VLC+T+F+RDQFSPDDFLGRTEI VA I+ +Q SKGP+T+ LLLHEV
Sbjct: 1645 SNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEV 1704
Query: 1651 PTGEVWVRFDLQLFEQ 1666
PTGE+ VR DLQLF++
Sbjct: 1705 PTGEIVVRLDLQLFDE 1720
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 1170 bits (3026), Expect = 0.0
Identities = 662/1255 (52%), Positives = 852/1255 (67%), Gaps = 126/1255 (10%)
Query: 2 MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
MAQFPT G ++WAIT EER KHD+QF +LKP G+ITGDQARNFF QSGLP PVLA+
Sbjct: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
Query: 62 IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP LPP+MKQ P+ A FGMG
Sbjct: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119
Query: 122 MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
+ ++ P+T+++ G+ +P + M LV SV T+++P NG +IQPL
Sbjct: 120 IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169
Query: 179 P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
P + ++TLP SS+S G +QKAQS D+ S +
Sbjct: 170 PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213
Query: 237 EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 214 EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
L AEEFILAMHL D+A +GQPLP LPPE +PPSFR G I I+ T LP
Sbjct: 274 LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333
Query: 349 KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
+++E+ Q KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 394 KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
Query: 467 RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
RQELLNQ+N+EQE+IV L +KKK L ELEALN K Q+ G+LQD+R + TQ+ E+E
Sbjct: 454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNT-PDSGVSLLHKKS 585
+K +L I EI LQQ+LQE Q L L+PEKQ+LN+++K +Q ++ DS V+L K++
Sbjct: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571
Query: 586 LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDK 644
LE +EL Q L++QLD +EKET SKL E+D FNNQLKELRE +N QQL ++ + +R K
Sbjct: 572 LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLK 631
Query: 645 LKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE--------EKQKRLQEEK 696
KE ERK +EL +K ++EA R+A Q ++ W E++++E+E E++K +EE
Sbjct: 632 QKEQERKIIEL---EKQKEEAQRRA-QERDKQWLEHVQQEDEHQRPRKLHEEEKLKREES 687
Query: 697 TQEKIQEEERKAE----------EKQRKDKDTLKA----EEKKRETASV-----LVNYRA 737
++K EE+ K E + Q K ++A EK T S +V YRA
Sbjct: 688 VKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRA 747
Query: 738 LYPFEARNHDEMSFNSGDIIQ-----VDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSS 792
LYPFE+R+HDE++ GDI+ VDE GEPGWL G +G GWFP NY EK+P +
Sbjct: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
Query: 793 E----------NEKAVSPKKALLPPTVSLSATS-------------TSSEPLSSNQPASV 829
E + A +PK AL L+ TS +S+ P S+N+
Sbjct: 808 EVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPET 867
Query: 830 TDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPG-SVSPIHGQGQVVENLKAQALCSWTAK 885
++ + +LTV ++ Q ++SAFT + G S SP+ GQG+ VE L+AQAL W AK
Sbjct: 868 DNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAK 927
Query: 886 KDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK--------REEP 937
KDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GWFPKSYVK+I G K E P
Sbjct: 928 KDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESP 987
Query: 938 EALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGD 997
+L + P + GEE+IA+Y Y S E GDLTF +G+ ILVT+KDG+WWTG++GD
Sbjct: 988 ASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKKDGDWWTGTVGD 1045
Query: 998 RSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILK 1057
++G+FPSNYV+ KD E G+A K+G+ KKPEIAQV ++Y A+G EQL+LAPGQLILI K
Sbjct: 1046 KAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRK 1105
Query: 1058 KNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHP-------VCQVIAMYD 1110
KN GWW+GELQARGKKRQ GWFPA++VKLL P + + TP P VCQVI MYD
Sbjct: 1106 KNPGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSKITPTEPPKSTALAAVCQVIGMYD 1165
Query: 1111 YAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQ 1165
Y A N+DEL+F+KGQ+INV+NK+DPDWW+GE+NG GLFPSNYVK+TTD DPSQQ
Sbjct: 1166 YTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQQ 1220
>gi|10864047 epidermal growth factor receptor pathway substrate
15-like 1 [Homo sapiens]
Length = 864
Score = 151 bits (382), Expect = 4e-36
Identities = 143/547 (26%), Positives = 246/547 (44%), Gaps = 110/547 (20%)
Query: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
WA+ EE+ K D F++L P G ++GD+ + + S LP VL +W LSD++KDG +D
Sbjct: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
Query: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA 135
+ EF++AM L+ L+ +P+P A
Sbjct: 181 RDEFAVAMHLVYRALE------------------------------------KEPVPSA- 203
Query: 136 PITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSS--STLPHGSSY 193
LPP ++P PS ++ G ++ P P S ST HGS
Sbjct: 204 -------------LPPSLIP----PSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVS 246
Query: 194 SLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFN 253
SL S+ S S SL P T W VP ++++ + F
Sbjct: 247 SL-------------------NSTGSLSPKHSLKQTQP---TVNWVVPVADKMRFDEIFL 284
Query: 254 TLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH-LTDMA 312
D + GY+SG + + + S L+Q LA IW LAD G+L ++F LAM+ +
Sbjct: 285 KTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKV 344
Query: 313 KAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYE 372
G P L P++VPPS RG DS +G+L S E K+L ++ + E
Sbjct: 345 SKGIDPPQVLSPDMVPPSERGTPGPDS-SGSLGS----GEFTGVKELDDISQEIAQLQRE 399
Query: 373 RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQREL 432
+ ++E + R + E+ R+ + Q+ + + +R+ LQE E +KQ + + RL+ E+
Sbjct: 400 KYSLEQDIREK---EEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ-DAQDRLD---EM 452
Query: 433 ERQREEERRKDIERREAAKQELERQRRLEWE-RIRRQELLNQK---NREQEEIVRLNSKK 488
++Q+ + R + R+ + E + L+ + + + +L +Q+ NR + E+ RL ++
Sbjct: 453 DQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEE 512
Query: 489 KNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE----L 544
L ++A GR+Q + K + T+ E+ Q ++ ++ + +QE L
Sbjct: 513 TQLEQSIQA---------GRVQLETIIKSLKSTQDEI--NQARSKLSQLHESRQEAHRSL 561
Query: 545 QEYQNKL 551
++Y L
Sbjct: 562 EQYDQVL 568
Score = 75.1 bits (183), Expect = 5e-13
Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
Query: 230 SPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLA 289
+P + + WAV + K+ F +L ++G LSG + + L+ S L L +W L+
Sbjct: 113 TPPSAEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLS 171
Query: 290 DVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR 332
D+D DG L +EF +AMHL A +P+P LPP L+PPS R
Sbjct: 172 DIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKR 214
Score = 48.1 bits (113), Expect = 7e-05
Identities = 43/200 (21%), Positives = 85/200 (42%), Gaps = 32/200 (16%)
Query: 442 KDIERREAAKQELERQRRLEWERIRR-----QELLNQKNREQEEIVRLNSKKKNLHLELE 496
++I + + K LE+ R + E IR+ QEL N +RE + L ++K++ L+
Sbjct: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450
Query: 497 ALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP 556
++ + ++ L DVR K Q + + L Q + ++K + +L
Sbjct: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDL------------ 498
Query: 557 EKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSF 616
N S ++ L ++ + E+ Q + QL+ + K S E++
Sbjct: 499 ---------------NRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQA 543
Query: 617 NNQLKELRETYNTQQLALEQ 636
++L +L E+ +LEQ
Sbjct: 544 RSKLSQLHESRQEAHRSLEQ 563
Score = 45.1 bits (105), Expect = 6e-04
Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Y + +D + +G + +A L +S LS L IW LAD +G G L + F +A+
Sbjct: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78
Query: 308 LTDMAKAGQPLPLT-LPPELVPPSF 331
L A++G + L+ L + PP F
Sbjct: 79 LVACAQSGHEVTLSNLNLSMPPPKF 103
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 131 bits (329), Expect = 6e-30
Identities = 111/427 (25%), Positives = 215/427 (50%), Gaps = 49/427 (11%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQR-----------EAERK 396
+K+QEEEPQ++ + E+++ ER EL + RQ +QQQR E ER+
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 397 AQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456
Q+E+ ++++RE QE+ ++QL E+ ++++L R++EEERR+ RRE ++ E+
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 457 QRRLEWERIRRQEL-------------LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQ 503
Q R E + R Q+L Q+ R ++++ R ++ L E +H+
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435
Query: 504 QISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQEL-----QEYQNKLIYLVPEK 558
Q + + + K+ Q+ + L ++ + E E ++ +Q+L +E + + + L E+
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Query: 559 QLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLK----------EQLDALEKETAS 608
+ + + Q + K+ E+E L QRL+ E+ + L K
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 609 KLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIER--KRLELMQKKKLEDEAA 666
K E + +LK +E Q L E+ + +R K ++ ER +RL+ + ++LE E
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 667 R----KAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA- 721
R K ++ +E ++ L+ EE+E++++ Q + Q++ +E+ K EE++ + + LK
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 722 -EEKKRE 727
EE++RE
Sbjct: 676 HEEERRE 682
Score = 120 bits (302), Expect = 8e-27
Identities = 110/410 (26%), Positives = 209/410 (50%), Gaps = 46/410 (11%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK-------- 399
Q EE Q++ E++ K R E EK Q L E++Q + +AQ+
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856
Query: 400 -EKEEWERKQRELQEQEWKKQLE---------------LEKRLEKQRELERQREEERRKD 443
E +E R Q + ++Q+W+ QLE L+++L K+++L ++ EEE +++
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 444 IERREAAKQELERQRRLEWERIRRQELLNQKNREQ---EEIVRLNSKKKNLHLELEALNG 500
ER + +QE ERQ R E + + +E L ++ RE+ +E R K K L + E L G
Sbjct: 917 -EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 501 KHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQL 560
+ + R + R KK ++ EL+ ++Q E E ++ Q+ ++Y+ K E+QL
Sbjct: 976 EEPE--KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033
Query: 561 LNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQL 620
L E + + ++ +EE Q+ +EQL E+ET + E++ +
Sbjct: 1034 LREEREKRRLQE---------RERQYREEEELQQEEEQLLGEERETRRR-QELERQYRKE 1083
Query: 621 KELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK--LEDEAARKAKQGKENLWK 678
+EL++ +QL E+ K +R + + R+ EL Q+++ L +E ++ +Q E ++
Sbjct: 1084 EELQQ--EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 679 ENLRKEEEEKQK-RLQEEK-TQEKIQEEERKAEEKQRKDKDTLKAEEKKR 726
E ++EE+Q R + EK +++++ + R+ EE Q++++ L+ E++KR
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR 1191
Score = 115 bits (289), Expect = 3e-25
Identities = 108/421 (25%), Positives = 218/421 (51%), Gaps = 33/421 (7%)
Query: 346 SYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQRE--AERKAQKEK-- 401
++++ QEEE ++ ++ + K+ ERG L R L EQ++R+ AE + Q+E+
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKS--ERGRQRL-SARPPLREQRERQLRAEERQQREQRF 810
Query: 402 --EEWERKQRELQEQEWKKQ---LELEKRLEKQRELERQREEE--RRKDIERREAAKQEL 454
EE E++QR Q +E +K+ LE E++L+++ ++ +EEE ++D ERR + +Q
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
Query: 455 ERQRR--LEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDV 512
+++ R LE ER RR+ L K QE++ + + EL+ + ++ + +
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQ----QELQEYQNKLIYLVPEKQLLNERIKNM 568
R ++Q Q+ E ++L ++ + + ++ Q ++LQ+ + +L+ PEK+ ER K
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 569 QFSNTPDSGVSLLHKKSLEKE-----ELCQRLKEQLDALEKETASKLSEMDSFNNQLKEL 623
+ L ++ EK E R K++L E++ + E + ++
Sbjct: 991 REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 624 RETYNTQ----QLALEQLYKIKRDKLKEIERKRLELMQKKK--LEDEAARKAKQGKENLW 677
RE Q QL E+ +R +L+ RK EL Q+++ L +E ++ +Q +E
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 678 K--ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNY 735
+ E L++EEE+ + +E++ +++++ + R+ EE Q++++ L+ E +KR + Y
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY 1170
Query: 736 R 736
R
Sbjct: 1171 R 1171
Score = 109 bits (272), Expect = 3e-23
Identities = 99/400 (24%), Positives = 196/400 (49%), Gaps = 36/400 (9%)
Query: 348 QKMQEEEPQKKLPVTFEDKR---KANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW 404
QK ++E +++L E++R K E E E+R+Q L Q+ E + K +EE
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Query: 405 ERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWER 464
R+Q+E +EQ QL E+ +++ L+RQ EEER +++R ++Q+L R++ E+
Sbjct: 496 RREQQERREQ----QLRREQEERREQRLKRQEEEER---LQQRLRSEQQLRREQEERREQ 548
Query: 465 I--RRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
+ R +E ++ R ++ + R ++++ L+ E + QQ R Q+ RL+++ ++ E
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKRE--EERRQQRLKREQEERLEQRLKREE 606
Query: 523 LEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLH 582
+E L+++ E ++L++E E + + L E+Q E + Q
Sbjct: 607 VERLEQEERRE----QRLKREEPEEERRQQLLKSEEQ---EERRQQQLRREQQERREQRL 659
Query: 583 KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQ---QLALEQLYK 639
K+ E+E L QRLK + + +E E + ++K + Q + Q
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719
Query: 640 IKRDKLKEIERKRLELMQKKK--------LEDEAARKAKQGKEN----LWKENLRKEEEE 687
R + +E +R+R E +K++ E+E A + +Q +E W+ ++ E
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 688 KQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 727
++RL + +E + +AEE+Q++++ L EE+K +
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ 819
Score = 107 bits (266), Expect = 1e-22
Identities = 90/384 (23%), Positives = 195/384 (50%), Gaps = 77/384 (20%)
Query: 352 EEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKE----KEEWERK 407
+E+ +K+ + E++ + E E EKRR+ E+Q RE E+ Q+E +EE E++
Sbjct: 896 QEQLRKEQQLLQEEEEELQRE----EREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951
Query: 408 QRELQEQEWKKQLELEKRLE--------KQRELERQRE--EERRKDIERREAAKQELERQ 457
+R+ +E++++K +L+++ E K+R ER+++ EE E + ++E E++
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 458 RRLEWERIRRQELLNQKNREQEEIVRLNSKKKNL------HLELEALNGKHQQISGRLQD 511
RR EWER R++ ++ +E+E+++R +K+ L + E E L + +Q+ G ++
Sbjct: 1012 RRQEWERQYRKK--DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERE 1069
Query: 512 VRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFS 571
R +++ ++ + ++ELQ+ + +L+ PEK+ ER
Sbjct: 1070 TRRRQELERQ----------------YRKEEELQQEEEQLLREEPEKRRRQER------- 1106
Query: 572 NTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQ 631
++ +EE Q+ +EQL E+E + +EL Y ++
Sbjct: 1107 -----------ERQCREEEELQQEEEQLLREERE-----------KRRRQELERQYREEE 1144
Query: 632 LALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKR 691
++ ++ R+ E E++R + ++++ E+E + +Q +E L +E K +E++++
Sbjct: 1145 EVQQEEEQLLRE---EPEKRRRQELERQYREEE---ELQQEEEQLLREEQEKRRQERERQ 1198
Query: 692 LQEEKTQEKIQEEERKAEEKQRKD 715
+EE+ ++ + ++R +E QR D
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSD 1222
Score = 106 bits (265), Expect = 2e-22
Identities = 108/412 (26%), Positives = 209/412 (50%), Gaps = 55/412 (13%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE----- 402
++ Q E +K+L E+++ ER +L++ L E Q+R ++ +++++
Sbjct: 820 RRRQRREREKELQFLEEEEQLQRRERAQ-QLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 403 EWERKQRE--------LQEQ---------EWKKQLELEKRLEKQR-ELERQREEERRKDI 444
E ERK+R LQEQ E +++L+ E+R +++R E ERQ EE +
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 445 ERREAAKQELERQRRLEWER-IRRQELLNQKNRE---QEEIVRLNSKKKNLHLELEALNG 500
E + ++E E++RR E ER R+ + L QK + +E R +++ + E E L
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 501 KHQQISGRLQDVRLKKQ-----TQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLV 555
+ +Q+ ++ R +++ +K EL+ ++Q E E ++LQ+ ++Y+ +
Sbjct: 999 EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Query: 556 PEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDS 615
E+QLL E + + ++ KEE Q+ +EQL E E + E +
Sbjct: 1059 EEEQLLGEERETRRRQEL---------ERQYRKEEELQQEEEQLLREEPEKRRR-QERER 1108
Query: 616 FNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK--LEDEAARKAKQGK 673
+ +EL++ +QL E+ K +R +L+ R+ E+ Q+++ L +E ++ +Q
Sbjct: 1109 QCREEEELQQ--EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL 1166
Query: 674 ENLWK--ENLRKEE-----EEKQKRLQEEKTQEKIQEEERKAEEKQR-KDKD 717
E ++ E L++EE EE++KR QE + Q + +EE ++ + KQR +D+D
Sbjct: 1167 ERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218
Score = 105 bits (263), Expect = 3e-22
Identities = 97/411 (23%), Positives = 209/411 (50%), Gaps = 27/411 (6%)
Query: 348 QKMQEEEPQKKLPVTFEDKR----KANYERGNMELEKRRQALMEQQ--QREAERKAQKEK 401
+++++E +++L E++R K ER L++ ++ +EQ+ + E ER Q+E+
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 402 EEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
E K+ E +E+ ++ L+ E++ E++++ R+ ++ERR+ +RE ++ LE++ + E
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 462 WERIRR-QELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQK 520
E RR QEL ++ + E ++ K LE EA + + ++ R + +++ Q+
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA-DARQSKVYSRPRKQEGQRRRQE 734
Query: 521 TELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP-EKQLLNERIKNMQFSNTPDSGVS 579
E + ++ +L+ E ++ ++ QE + + + + + +ER + + P +
Sbjct: 735 QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP---LR 791
Query: 580 LLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYK 639
++ L EE QR + L E+E + + +L+ L E Q+ Q +
Sbjct: 792 EQRERQLRAEERQQREQRFLPE-EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Query: 640 IKRDKLKEIERKRLELMQKK------KLEDEAARK-----AKQG-KENLWKEN--LRKEE 685
+ D L+E + +R Q++ +LE+E R+ AK +E L KE L++EE
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910
Query: 686 EEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYR 736
EE Q+ +E++ +++ + + R+ E+ Q++++ L+ E +KR YR
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961
Score = 104 bits (259), Expect = 8e-22
Identities = 110/453 (24%), Positives = 221/453 (48%), Gaps = 55/453 (12%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMEL-----EKRRQALMEQQQREAERKAQKEKEEWE 405
QEEE +++ E++R+ ER +L E+R Q L Q++ E ++ + +++
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 406 RKQRELQEQEWKKQLELEKRLEKQRELER-QREEERRKD--IERREAAKQEL---ERQRR 459
R+Q E +EQ K+ E EKRLE++R +R +RE+E R+D ++R E +Q+ E++ R
Sbjct: 540 REQEERREQLLKR--EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 460 LEWERIRRQEL--LNQKNREQEEIVRLN---SKKKNLHLELEALNGKHQQISGRLQDVRL 514
LE +R++R+E+ L Q+ R ++ + R +++ L E + QQ+ Q+ R
Sbjct: 598 LE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 515 KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM------ 568
++ ++ E E L+++ E E ++ +QEL E E++ ERIK+
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERR-EQELAE---------EEQEQARERIKSRIPKWQW 706
Query: 569 QFSNTPDSGVSLLH---------KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQ 619
Q + D+ S ++ ++ E+EE +R + +L E+E A + + +
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Query: 620 LK-----ELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKE 674
E + Q+L+ + +R++ E ++ + E+E ++ +Q +E
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826
Query: 675 NLWKENLRKEEEEKQKR-----LQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETA 729
+ +EEE+ Q+R LQEE+ + +E R+++E++R K + EE+++
Sbjct: 827 REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886
Query: 730 SVLVNYRALYPFEARNHDEMSFNSGDIIQVDEK 762
L AL + R ++ + +Q +E+
Sbjct: 887 HTLYAKPALQE-QLRKEQQLLQEEEEELQREER 918
Score = 104 bits (259), Expect = 8e-22
Identities = 97/422 (22%), Positives = 201/422 (47%), Gaps = 48/422 (11%)
Query: 338 DSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKA 397
+ I +P +Q E E + + RK +R E E++R+ + Q + E +A
Sbjct: 695 ERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERA 754
Query: 398 QKEKEE--------WERKQRELQE-------------QEWKKQLELEKRLEKQREL--ER 434
++++E W+ + E E ++ ++QL E+R ++++ E
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE 814
Query: 435 QREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNS------KK 488
+ +E+RR+ RE Q LE + +L+ R R Q+L +++ QE+ R S +K
Sbjct: 815 EEKEQRRRQRREREKELQFLEEEEQLQ-RRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873
Query: 489 KNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQ 548
LE E +H + +L+K+ Q + E +++ E E ++ Q++ ++Y+
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE--EEELQREEREKRRRQEQERQYR 931
Query: 549 NKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETAS 608
+ E+QLL E + + ++ K++ Q+ +EQL E E
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQE---------RERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 609 KLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK--LEDEAA 666
+ E + + +EL++ +QL E+ K +R + + RK+ EL Q+++ L +E
Sbjct: 983 R-QEREKKYREEEELQQ--EEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 667 RKAKQGKENLWK--ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEK 724
++ Q +E ++ E L++EEE+ +E + +++++ + RK EE Q++++ L+ E +
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Query: 725 KR 726
KR
Sbjct: 1100 KR 1101
Score = 104 bits (259), Expect = 8e-22
Identities = 101/397 (25%), Positives = 200/397 (50%), Gaps = 31/397 (7%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW--- 404
+K +EEE Q L D++ E+ E+ R+ L E+QQ ER + +EE
Sbjct: 1414 RKFREEEQQ--LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471
Query: 405 ERKQRELQEQEW-KKQLELEKRLEKQRELERQREEERRKDIERRE--AAKQELERQRRL- 460
ER++++L QE +K LE E++L +Q + RE+E R R+ +Q+L RQ+R
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR 1531
Query: 461 ----EWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKK 516
E +++RRQE Q+ ++++ R +++ L E E QQ+S + +D + +
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFR---EEEQLRQERE-----EQQLSRQERDRKFRL 1583
Query: 517 QTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDS 576
+ QK + +++ + ++++ + + Q Q + ++QLL ER + Q
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER-EEQQLHRQERD 1642
Query: 577 GVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQ 636
L + L ++E Q+L+ D +E L E + + +E + ++ +Q
Sbjct: 1643 RKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE---QQ 1699
Query: 637 LYKIKRDK--LKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQE 694
L + +R++ L+E ++ R + +++K E+E R+ + ++ +E RK EE+Q R +
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759
Query: 695 EKTQEKIQEEERKAEE----KQRKDKDTLKAEEKKRE 727
E+ Q + QE +RK E +Q +++ L+++E R+
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796
Score = 103 bits (258), Expect = 1e-21
Identities = 96/384 (25%), Positives = 195/384 (50%), Gaps = 34/384 (8%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQR--EAERKAQKEKEEWE 405
Q +QE E Q+ E RK E + ++R + EQ+ R E ERK +E+++
Sbjct: 1468 QLLQEREEQQLHRQ--ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 406 RKQRE---LQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
R+QR+ LQE++ ++ E ++ + R+ + + EE+ R++ E ++ ++QE +R+ RLE
Sbjct: 1526 RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585
Query: 463 ERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
+++RRQE +K E E+ +R ++ L E + + +Q+ ++ +L +Q +
Sbjct: 1586 QKVRRQE-QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER--- 1641
Query: 523 LEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLH 582
D++ E ++++ ++E Q ++ E+QLL E + D
Sbjct: 1642 ----DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD------- 1690
Query: 583 KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKR 642
+K E+E+ +R + + L++E + E++ + ++LR+ +QL ++ Y+
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR--- 1747
Query: 643 DKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQ 702
K+ E E+ R E +++ E RK ++ +E LR+E EE+Q R QE + K +
Sbjct: 1748 -KILEEEQLRPEREEQQLRRQERDRKFRE------EEQLRQEREEQQLRSQE--SDRKFR 1798
Query: 703 EEERKAEEKQRKDKDTLKAEEKKR 726
EEE+ +E++ + + + K R
Sbjct: 1799 EEEQLRQEREEQQLRPQQRDGKYR 1822
Score = 103 bits (257), Expect = 1e-21
Identities = 101/417 (24%), Positives = 212/417 (50%), Gaps = 45/417 (10%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
++ +++E +++ + E+K+ ER EKRR+ +++ RE E+ Q+ +E+ R+
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREERE----EKRRRQETDRKFREEEQLLQEREEQPLRR 1355
Query: 408 Q---RELQEQEWKKQLELEKRLEKQRELERQ-------REEERRKDIERREAAKQELERQ 457
Q R+ +E+E + Q + K LE+++ L RQ +EE++ + ER + +Q+ +R+
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415
Query: 458 RRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKH------QQISGRLQD 511
R E +++ RQE + E++++ R ++K L E + +H +Q+ ++
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475
Query: 512 VRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER-----IK 566
+L +Q + + ++Q + + K +QEL+ + + +L E+QL ++ ++
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535
Query: 567 NMQFSNTPDSGVSLLH---KKSLEKEELCQ-RLKEQLDALEKETASKLSEMD-------- 614
Q + G +K E+E+L Q R ++QL E++ +L E
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595
Query: 615 SFNNQLKELRETYNTQQLALEQLYKIKRDK--LKEIERKRLELMQ--KKKLEDEAARKAK 670
F ++LR QQL E+ K + D+ L+E E ++L + +K LE+E + +
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 671 QGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 727
+ ++ L + RK EE+Q + E+ Q + QE +RK E++++ L+ +E++R+
Sbjct: 1656 EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ----LRRQERERK 1708
Score = 102 bits (255), Expect = 2e-21
Identities = 106/405 (26%), Positives = 204/405 (50%), Gaps = 41/405 (10%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNM---ELEKRRQALMEQQQREAERKAQKEKEEW 404
+K + +E +KK + ++ + E + E EKRR+ E+Q R+ + + Q+E+E+
Sbjct: 979 EKRRRQEREKK----YREEEELQQEEEQLLREEREKRRRQEWERQYRKKD-ELQQEEEQL 1033
Query: 405 ERKQRE---LQEQEWKKQLELEKRLEKQRELERQREEERRKDIERR----EAAKQELERQ 457
R++RE LQE+E + + E E + E+++ L +RE RR+++ER+ E +QE E+
Sbjct: 1034 LREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Query: 458 RRLEWERIRRQELLNQKNRE-----QEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDV 512
R E E+ RRQE Q E +EE + ++K ELE + +++ + ++
Sbjct: 1094 LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ-QEEEQ 1152
Query: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNE----RIKNM 568
L+++ +K + L++Q E E++Q +++L + + E+Q E R K
Sbjct: 1153 LLREEPEKRRRQELERQY-REEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Query: 569 QFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYN 628
Q D L + EKE + K E E +L + +QL++ + +
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED-----SQLRDRQSQQD 1266
Query: 629 TQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQ--GKENLWKENLRKEEE 686
Q L EQ + + + + +++ ++++LE E ++AK+ K K+ LR+E E
Sbjct: 1267 LQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREERE 1326
Query: 687 EKQKRLQEEKTQEKIQEEERKAEEKQ-----RKDKDTLKAEEKKR 726
EK++R ++T K +EEE+ +E++ R+++D EE+ R
Sbjct: 1327 EKRRR---QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368
Score = 100 bits (250), Expect = 9e-21
Identities = 92/406 (22%), Positives = 204/406 (50%), Gaps = 46/406 (11%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNM---ELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+E+ +++L + ++ + E + E EKRR+ +E+Q RE E + Q+E+E+ R+
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE-EEELQQEEEQLLRE 1186
Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDI------ERREAAK--------QE 453
++E + QE ++Q E+ L++Q+ +R R+E++R D+ E+ A + +E
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246
Query: 454 LERQRRLEWERIR-------RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
E+ R+LE ++R Q LL ++ E R ++++ H E + +Q
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE 1306
Query: 507 GRLQDVRLKKQTQKTELEVLDK----QCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLN 562
+ +D + +++ Q E +K + D + E +QL QE +E L +++
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE--QPLRRQERDRKFRE 1364
Query: 563 ERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKE 622
E +++ + +K LE+E+ +R + + L++E + E + Q ++
Sbjct: 1365 EELRHQEQG-----------RKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Query: 623 LRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLR 682
+ QQL+ ++ + R++ +++ R+ E +K LE+E + ++ ++ +E L
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERE---RKFLEEEQQLRQERHRKFREEEQLL 1470
Query: 683 KEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKD-TLKAEEKKRE 727
+E EE+Q QE + +E++ + +E+ RK ++ L+++E +R+
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516
Score = 98.2 bits (243), Expect = 6e-20
Identities = 89/392 (22%), Positives = 197/392 (50%), Gaps = 32/392 (8%)
Query: 364 EDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWK------ 417
+++++A + L+ RRQ E Q+R R Q E+E +R++++ QEQE +
Sbjct: 96 DEEKRARCDGKESLLQDRRQE--EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE 153
Query: 418 ---KQLELEKRLEKQRELERQREEERRKDIERREAAKQEL------ERQRRLEWERIRRQ 468
KQ LE+R ++R+ E R+ + ++ E R A +++L E + + E++RR+
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 469 EL--LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
EL L +K RE+++ R ++ + E E + ++ R ++ +L+++ + + E+
Sbjct: 214 ELLELRRKGREEKQQQR-RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQL-----------LNERIKNMQFSNTPD 575
+++ L +E ++L++E QE + + L E+QL ER + + +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 576 SGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALE 635
++ E+ Q +EQ + ++ + E + QL+ ++ QQL E
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392
Query: 636 QLYKIKRDKLKEIE-RKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQE 694
Q + ++ +E + R+ +L ++++L E + +Q +E +++ ++ E++ KR QE
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 695 EKTQEKIQEEERKAEEKQRKDKDTLKAEEKKR 726
E+ +EEE + E++R+ + + +E++R
Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQEEER 484
Score = 98.2 bits (243), Expect = 6e-20
Identities = 98/451 (21%), Positives = 209/451 (46%), Gaps = 75/451 (16%)
Query: 345 PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW 404
P ++ Q+ + Q++ E++ + + ++R + L Q+Q ER+ ++ +EE
Sbjct: 133 PGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQ 192
Query: 405 -------------------------------ERKQ-----------RELQEQEW-KKQLE 421
E KQ +E +E+EW K++
Sbjct: 193 LQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV 252
Query: 422 LEKRLEKQRELERQREEERRKDIER-REAAKQELERQRRLE---WERIRRQELLNQK--- 474
L K EK +E E QR+ E +++ E+ R+ +QEL R+R+ E +R+RR++ L +K
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312
Query: 475 --------NREQEEIVRLNSKKKNLHLELEALNGKHQQI------SGRLQDVRLKKQTQK 520
REQ+E +++ L E + QQ+ R Q +R +++ ++
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 521 TELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSL 580
E ++ +Q ++++ QQ +E Q + + +Q L + +
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 581 LHKKSLEKEELCQRLK----EQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQ 636
H++ E+E QRLK E+ D L++E ++ E + QLK + ++ E+
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR-----DQEEERRER 487
Query: 637 LYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK 696
K++ ++ +E + +R + +++++ E R +Q +E ++ LR E++ +R QEE+
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ--LRREQEER 545
Query: 697 TQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 727
++ ++ EE K E++R+++ + +E++R+
Sbjct: 546 REQLLKREEEKRLEQERREQRLKREQEERRD 576
Score = 98.2 bits (243), Expect = 6e-20
Identities = 100/427 (23%), Positives = 217/427 (50%), Gaps = 40/427 (9%)
Query: 344 LPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK-EKE 402
L Q++ ++ Q+K E+++ ERG + R + E++Q ER+ Q+ ++
Sbjct: 1518 LEEEQQLHRQQRQRKF--LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ 1575
Query: 403 EWERKQRELQEQEWKKQLELEKRLEKQRELERQR-EEERRKDIERREAAKQELERQRRLE 461
E +RK R L+EQ+ ++Q + K +E +++L RQ +++ R++ +R+ ++L ++R E
Sbjct: 1576 ERDRKFR-LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER--E 1632
Query: 462 WERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT 521
+++ RQE ++K E+E +R +++ L + + + +Q+ ++ +L++Q +
Sbjct: 1633 EQQLHRQER-DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 522 ELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
+ ++Q + E K LQ+E Q + +L E++ L + + Q + +L
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ-ERYRKIL 1750
Query: 582 HKKSLEKEELCQRLK-----------EQLDALEKETASKLSEMDSFNNQLKELRETYNTQ 630
++ L E Q+L+ EQL +E + E D + ++LR+ Q
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810
Query: 631 QLALEQL---YKIKRDKLK---EIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKE 684
QL +Q Y+ + ++L+ + +R R E ++ + E++ A + K +E ++ L +E
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE---EQELWQE 1867
Query: 685 EEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKK----------RETASVLVN 734
EE+K+++ +E K +E+ ++K E++ R+ + +K++E K + ASV V
Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGE-IKSQEGKGHGRLLEPGTHQFASVPVR 1926
Query: 735 YRALYPF 741
LY +
Sbjct: 1927 SSPLYEY 1933
Score = 97.4 bits (241), Expect = 1e-19
Identities = 91/400 (22%), Positives = 201/400 (50%), Gaps = 31/400 (7%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNME--LEKRRQALMEQQQREAERKAQKEKEEWERKQ 408
QEE Q++L +++R+ +R E LE+R + E+++RE E +++++ ER +
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698
Query: 409 RELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQ 468
+ + +W+ + E + R K R++E +RR R+E ++ R+ L+W+ R
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRR----RQEQEEKRRRRESELQWQEEER- 753
Query: 469 ELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGR--LQDVRLKKQTQKTELEVL 526
+R+Q+E + E ++ G+ Q++S R L++ R ++Q + E +
Sbjct: 754 -----AHRQQQEEEQRRDFTWQWQAEEKSERGR-QRLSARPPLREQR-ERQLRAEERQQR 806
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSL 586
+++ E E +Q +++ +E + +L +L E+Q L R + Q D ++
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ-LQRRERAQQLQEEEDGLQEDQERRRS 865
Query: 587 EKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLK 646
+++ Q+ + QL+ K L + QL++ ++ ++ E+L + +R+K +
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE---EELQREEREKRR 922
Query: 647 EIERKR-------LELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQE 699
E++R L+ +++ L +E ++ +Q +E ++++ + +++E+Q L EE +
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ-LLGEEPEKR 981
Query: 700 KIQEEERK---AEEKQRKDKDTLKAEEKKRETASVLVNYR 736
+ QE E+K EE Q++++ L+ E +KR YR
Sbjct: 982 RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021
Score = 97.1 bits (240), Expect = 1e-19
Identities = 108/464 (23%), Positives = 220/464 (47%), Gaps = 71/464 (15%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
Q++ +EE ++ E +R+ ER E E+ +Q + + E E++ ++E+E RK
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962
Query: 408 QRELQEQEWKKQL---ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWER 464
++LQ++E +QL E EKR ++RE + + EEE ++ E + ++E E++RR EWER
Sbjct: 963 DKKLQQKE--EQLLGEEPEKRRRQEREKKYREEEELQQ--EEEQLLREEREKRRRQEWER 1018
Query: 465 IRRQELLNQKNREQEEIVRLNSKKKNL------HLELEALNGKHQQISGRLQDVRLKKQT 518
R++ ++ +E+E+++R +K+ L + E E L + +Q+ G ++ R +++
Sbjct: 1019 QYRKK--DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 519 QKT-----ELEVLDKQCDLEIMEIKQLQQ---------ELQEYQNKLIYLVPEKQLLNER 564
++ EL+ ++Q E E ++ Q+ ELQ+ + +L+ EK+ E
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 565 IKNMQFSNTPDSGVSLLHKKSLEK---EELCQRLKEQLDALEKETASKLSEMDSFNNQLK 621
+ + L ++ EK +EL ++ +E+ + L++E L E Q +
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE-EELQQEEEQLLREEQEKRRQER 1195
Query: 622 E--LRETYNTQQLALEQLYKIK--RDKLK--------------EIERKRLELMQKKKLED 663
E RE Q+ +Q Y+ + R LK ++ K E Q ++LED
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED 1255
Query: 664 EAAR--KAKQGKENLWKENLRKEEEEKQKRLQ------------------EEKTQEKIQE 703
R +++Q ++L E ++ E++++R Q E K +++ +
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315
Query: 704 EERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHD 747
EE++ ++R++K + ++K L+ R P + D
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359
Score = 96.7 bits (239), Expect = 2e-19
Identities = 100/465 (21%), Positives = 223/465 (47%), Gaps = 48/465 (10%)
Query: 285 IWTLADVDGDGQLKAEEFILAMHLTDMA---KAGQPLPLTLPPELVPPSFRGGKQIDSIN 341
I L D+D +G++ EF+L + A GQ L ++ +
Sbjct: 57 ILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLD------------EEKRARCD 104
Query: 342 GTLPSYQKMQEEEPQKKLPVTFEDK-RKANYERGNMELEKRRQA---------LMEQQQR 391
G Q ++EE Q++ FE + R+ E G +KR++ E+Q+R
Sbjct: 105 GKESLLQDRRQEEDQRR----FEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQER 160
Query: 392 EAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEE---RRKDIERRE 448
+R Q+ EE R+++E QE+E ++ E + + K E E +EE RR+ +E R
Sbjct: 161 LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRR 220
Query: 449 AAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKK---KNLHLELEALNGKHQQI 505
++E ++QRR +R+ ++E ++ R++E ++R +K + + E + Q
Sbjct: 221 KGREEKQQQRRERQDRVFQEE-EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR 279
Query: 506 SGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERI 565
Q++R ++Q ++ + + L ++ L + ++ +++ +E + + E++ E
Sbjct: 280 KLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ-----QERREQQEER 334
Query: 566 KNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRE 625
+ Q + ++ E+E Q+L+ + + +E + + QL+ ++
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Query: 626 TYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEE 685
QQL EQ + ++ +E + +R + +++++ E+ +K +Q + ++ L++E+
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR---EQRLKREQ 451
Query: 686 EEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDT----LKAEEKKR 726
EE++ L+ E+ E+ ++E RK + K+ ++++ LK EE++R
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Score = 94.0 bits (232), Expect = 1e-18
Identities = 93/371 (25%), Positives = 188/371 (50%), Gaps = 33/371 (8%)
Query: 379 EKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQREL---ERQ 435
E++R ++ +R+ ++++ +E + R+L+E+ +++ + KR E++REL E Q
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ--KRQEQERELAEGEEQ 154
Query: 436 REEERRKDIERREAAKQELERQRRLEWE-----RIRRQELLNQKNREQEEIVRLNSKKKN 490
E++ R + R+ +EL RQR+ EW+ R ++L + K E EE ++
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQ-EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 491 LHLELEALNGKHQQISGRLQDVRLKKQTQKTELE----VLDKQCDLEIMEIKQLQQELQE 546
LEL + +Q R + R+ ++ ++ E VL K+ + E Q Q+ELQE
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 547 YQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKET 606
+ +L L ++L ER + Q L K+ E+ E + +EQ + E++
Sbjct: 274 EEEQLRKL-ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 607 ASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLK---EIERKRLELMQKKKLED 663
+ QL+ +E QQL EQ + + +L+ E ER+ +L ++++L
Sbjct: 333 ERR-------EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRR 385
Query: 664 EAARKAKQ---GKENLWKE-NLRKEEE-EKQKRLQEEKTQEKIQEEER--KAEEKQRKDK 716
E + +Q ++ L +E LR+E++ ++++L+ E+ + QEEER + E++R+++
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 717 DTLKAEEKKRE 727
+ +E++R+
Sbjct: 446 RLKREQEERRD 456
Score = 94.0 bits (232), Expect = 1e-18
Identities = 97/395 (24%), Positives = 196/395 (49%), Gaps = 36/395 (9%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+++Q+EE Q L E +R+ ER E E+ +Q E++Q E + ++ ++E ER+
Sbjct: 1084 EELQQEEEQL-LREEPEKRRRQERERQCREEEELQQ---EEEQLLREEREKRRRQELERQ 1139
Query: 408 QRELQEQEWKKQLELEKRLEKQR--ELERQREEERRKDIERREAAKQELERQRRLEWER- 464
RE +E + +++ L + EK+R ELERQ EE E + ++E E+ RR E ER
Sbjct: 1140 YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK-RRQERERQ 1198
Query: 465 IRRQELLNQKNREQEEIVRLNSKKKNLHLELEA------------LNGKHQQISGRLQDV 512
R +E L ++ R+Q R ++ +L + E G+ + +L+D
Sbjct: 1199 YREEEELQRQKRKQR--YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256
Query: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSN 572
+L+ + + +L+ L L + + +QE + +Q + + E+QL E K + +
Sbjct: 1257 QLRDRQSQQDLQHL-----LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Query: 573 TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQL 632
S K+ L +E +R +++ D +E L E + + +E + ++L
Sbjct: 1312 RK----SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL 1367
Query: 633 ALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRL 692
++ R L+E +R R + ++K L++E + ++ ++ L ++ RK EE+Q +L
Sbjct: 1368 RHQEQ---GRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ-QL 1423
Query: 693 QEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 727
++ K +EEE++ +Q +++ L+ E++ R+
Sbjct: 1424 SRQERDRKFREEEQQV-RRQERERKFLEEEQQLRQ 1457
Score = 90.9 bits (224), Expect = 9e-18
Identities = 106/418 (25%), Positives = 205/418 (49%), Gaps = 42/418 (10%)
Query: 345 PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKE---- 400
P ++ QE E Q + E+ ++ + E EKRR+ +E+Q RE E Q+E
Sbjct: 1098 PEKRRRQERERQCREE---EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 401 KEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL 460
+EE E+++R+ E++++++ EL+ +++ +L R+ +E+RR++ ER+ ++EL+RQ+R
Sbjct: 1155 REEPEKRRRQELERQYREEEELQ---QEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Query: 461 EWERI--RRQELLNQKNREQEEIVRLNS-----KKKNLHLELEALNGKHQQISGRLQDVR 513
+ R +R +L Q E+E VR N ++ +LE + +Q LQ +
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 514 LKKQTQKTELEVLD-KQCDLEIMEIKQLQQELQ-EYQNKLIYLVPEKQLLNERIKNMQFS 571
++Q + E E +Q D E +QL++E Q E + + EKQLL E + +
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 572 NTPDSGV----SLLHKKS---LEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELR 624
D LL ++ L ++E ++ +E+ +++ L E Q +E +
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERK 1391
Query: 625 ETYNTQQLALE----QLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKEN 680
QQL + QL + + K +E E++ + +K +E + +Q +E + E
Sbjct: 1392 FLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEE 1451
Query: 681 ---LRKE------EEEKQKRLQEEKTQEKIQEEERKAEEKQ---RKDKDTLKAEEKKR 726
LR+E EEE+ + +EE+ + + + + EE+Q R+++D E++ R
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509
Score = 87.8 bits (216), Expect = 8e-17
Identities = 82/381 (21%), Positives = 185/381 (48%), Gaps = 53/381 (13%)
Query: 373 RGNMELEKRRQALMEQQQREAERKAQK---------EKEEWERKQRELQEQEWKKQLELE 423
R + + L EQQ+R+ E++ ++ E+E+ ER++++ ++ +K E +
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318
Query: 424 KRLEKQRELERQREEERRKDI--------ERREAAKQELERQRRLEWERIRRQELLNQKN 475
+ L ++RE E++R +E + ER E + ER R+ E +R QE +
Sbjct: 1319 QLLREERE-EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Query: 476 REQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIM 535
E++ + R ++K L E + + +Q + +D + +++ Q+ + D+
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR------- 1430
Query: 536 EIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRL 595
+ ++ +Q+++ + + +L E+QL ER H+K E+E+L Q
Sbjct: 1431 KFREEEQQVRRQERERKFLEEEQQLRQER-----------------HRKFREEEQLLQER 1473
Query: 596 KEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLAL---EQLYKIKRDKLKEIERKR 652
+EQ ++ L E Q ++ + + Q+L E+ + + +L +R+R
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRK--FREQELRSQEPERKFLEEEQQLHRQQRQR 1531
Query: 653 LELMQKKKL-EDEAARKAKQGKENLWK--ENLRKEEEEKQKRLQEEKTQEKIQEEERKAE 709
L ++++L E ++ +Q ++ ++ E LR+E EE+Q QE + +++E++ + +
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591
Query: 710 EKQRK---DKDTLKAEEKKRE 727
E++RK D+ L+ +E +++
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQ 1612
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 127 bits (318), Expect = 1e-28
Identities = 105/368 (28%), Positives = 185/368 (50%), Gaps = 32/368 (8%)
Query: 1162 PSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEG 1221
P+ Q + L ++P E KRQ I+EL TE ++ L+++ +VF +R++ G L+
Sbjct: 767 PNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPS 826
Query: 1222 EMALIFVNWKELIMSNTKL---LKALRVRKKTGGEKMPVQMIGDILAA--------ELSH 1270
E+ IF N ++++ + L +KA+R R +T + IG+ L +L H
Sbjct: 827 ELRKIFSNLEDILQLHIGLNEQMKAVRKRNETS----VIDQIGEDLLTWFSGPGEEKLKH 882
Query: 1271 MQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRY 1330
A FCS Q +++ + +D+ F+ F++ S+P C+ + L + MQR+T+Y
Sbjct: 883 AAA--TFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKY 940
Query: 1331 PLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEG- 1389
PLL+ +I + T E + +K A + ++ + VN+ V+E EN RLE Q +
Sbjct: 941 PLLLDNIAKYT-EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSL 999
Query: 1390 -LAEQLIFNSLTNC-LGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVS 1444
L+E L N L RK++H G L +K +K +L+ L D L+L V
Sbjct: 1000 KLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVL 1059
Query: 1445 SGSEKLFSSKSNAQFKMYKTPIFLNEVLVK-LPTDPSSDEPVFHISHID---RVYTLRTD 1500
K+ +S ++++ + I L+ VLV+ + TD ++ +F IS D ++Y L
Sbjct: 1060 RCHSKILASTADSK-HTFSPVIKLSTVLVRQVATD---NKALFVISMSDNGAQIYELVAQ 1115
Query: 1501 NINERTAW 1508
++E+T W
Sbjct: 1116 TVSEKTVW 1123
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 125 bits (314), Expect = 3e-28
Identities = 131/526 (24%), Positives = 224/526 (42%), Gaps = 52/526 (9%)
Query: 25 KHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMK 84
K+ RQ D + G + A F +SGLP +L +IW L+D + G +++QEF +A++
Sbjct: 21 KYYRQVDT--GNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Query: 85 LIKLKLQGQQLPVVLPPIMKQPPMF----SPLISARFGMGSMPNLSIPQPLPPAAPITSL 140
L+ G ++ + + PP F SPL+ + +P P+ I
Sbjct: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDS 138
Query: 141 SSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGF 200
S +G + + P + S LP + L + S + H G
Sbjct: 139 LSPVNG-----FLSGDKVKPVLLNSKLP------VDILGRVWELSDIDHD-------GML 180
Query: 201 GGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMS 260
A L+ + P + W V + KY + F DK M
Sbjct: 181 DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD 240
Query: 261 GYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTD--MAKAGQPL 318
G++SG + R L++ L T LA IW+L D G+L ++F LA HL + K P
Sbjct: 241 GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDP- 299
Query: 319 PLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMEL 378
P L PE++PPS R Q +I G+ P + + K+L + E+ N+E
Sbjct: 300 PHVLTPEMIPPSDRASLQ-KNIIGSSP----VADFSAIKELDTLNNEIVDLQREKNNVEQ 354
Query: 379 EKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREE 438
+ + + +Q+ + Q E + ++LQ Q+ + Q L++ E++ +LE Q +E
Sbjct: 355 DLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 414
Query: 439 ERRKDIERRE---AAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL 495
R+K E + + K EL Q +I E + + +EE+ RL + L +
Sbjct: 415 VRKKCAEEAQLISSLKAELTSQE----SQISTYE--EELAKAREELSRLQQETAELEESV 468
Query: 496 EALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQ 541
E SG+ Q L++ Q ++ E+ Q +++ME+K L+
Sbjct: 469 E---------SGKAQLEPLQQHLQDSQQEISSMQ--MKLMEMKDLE 503
Score = 103 bits (257), Expect = 1e-21
Identities = 112/461 (24%), Positives = 185/461 (40%), Gaps = 79/461 (17%)
Query: 220 TSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQ 279
TSS +SG S WAV + KY F++L ++G+LSG + + LL S L
Sbjct: 106 TSSPLLISGTS--AAELPWAVKPEDKAKYDAIFDSLSP-VNGFLSGDKVKPVLLNSKLPV 162
Query: 280 TQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDS 339
L +W L+D+D DG L +EF +AM L A +P+P++LPP LVP
Sbjct: 163 DILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVP----------- 211
Query: 340 INGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQ-REAERKAQ 398
P K+ KA Y+ ++ +K + + RE K
Sbjct: 212 ---------------PSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTG 256
Query: 399 KEK----EEWERKQRELQEQEWKKQLELEKRLEKQRELE-----RQREEERRKDIERREA 449
W + + K Q L L Q+ ++ E +R
Sbjct: 257 LPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASL 316
Query: 450 AKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRL 509
K + ++ I+ + LN EIV L +K N+ +L+ +Q + +
Sbjct: 317 QKNIIGSSPVADFSAIKELDTLNN------EIVDLQREKNNVEQDLKEKEDTIKQRTSEV 370
Query: 510 QDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
QD++ + Q + T L+ +LQ + Q+ Q L L +K L E++K ++
Sbjct: 371 QDLQDEVQRENTNLQ--------------KLQAQKQQVQELLDELDEQKAQLEEQLKEVR 416
Query: 570 FSNTPDSGVSLLHKKSLEKEELCQRLK-------EQLDALEKETASKLSEMDSFNNQLKE 622
KK E+ +L LK Q+ E+E A E+ + E
Sbjct: 417 -------------KKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAE 463
Query: 623 LRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLED 663
L E+ + + LE L + +D +EI +++LM+ K LE+
Sbjct: 464 LEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLEN 504
Score = 85.9 bits (211), Expect = 3e-16
Identities = 35/91 (38%), Positives = 59/91 (64%)
Query: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
WA+ E++ K+D FD+L P G+++GD+ + L S LP +L +W LSD++ DG +D
Sbjct: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181
Query: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQP 106
+ EF++AM L+ L+ + +P+ LPP + P
Sbjct: 182 RDEFAVAMFLVYCALEKEPVPMSLPPALVPP 212
Score = 64.7 bits (156), Expect = 7e-10
Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 2/93 (2%)
Query: 16 WAITSEERTKHDRQFDNL-KPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74
W ++ E+ K+D F K G+++G + R FL++GLP+ +LA IW+L D GK+
Sbjct: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
Query: 75 DQQEFSIAMKLIKLKL-QGQQLPVVLPPIMKQP 106
+ +F++A LI KL +G P VL P M P
Sbjct: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPP 310
Score = 46.2 bits (108), Expect = 3e-04
Identities = 36/126 (28%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Y + + +D +G + A L +S L L IW LAD DG G L +EF +A+
Sbjct: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Query: 308 LTDMAKAGQPLPL-TLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDK 366
L A+ G + L +L + PP F I+GT + +LP + +
Sbjct: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAA-----------ELPWAVKPE 127
Query: 367 RKANYE 372
KA Y+
Sbjct: 128 DKAKYD 133
Score = 45.1 bits (105), Expect = 6e-04
Identities = 41/195 (21%), Positives = 86/195 (44%), Gaps = 34/195 (17%)
Query: 438 EERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEA 497
+ + ++E+ K++ +QR E Q+L ++ RE + +L ++K+ + L+
Sbjct: 346 QREKNNVEQDLKEKEDTIKQRTSEV-----QDLQDEVQRENTNLQKLQAQKQQVQELLDE 400
Query: 498 LNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPE 557
L+ + Q+ +L++VR K+C E I L+ EL ++++ E
Sbjct: 401 LDEQKAQLEEQLKEVR--------------KKCAEEAQLISSLKAELTSQESQISTYEEE 446
Query: 558 KQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFN 617
E + +Q +++ E EE + K QL+ L++ E+ S
Sbjct: 447 LAKAREELSRLQ-------------QETAELEESVESGKAQLEPLQQHLQDSQQEISSMQ 493
Query: 618 NQLKELR--ETYNTQ 630
+L E++ E +N+Q
Sbjct: 494 MKLMEMKDLENHNSQ 508
Score = 38.5 bits (88), Expect = 0.055
Identities = 38/125 (30%), Positives = 64/125 (51%), Gaps = 20/125 (16%)
Query: 608 SKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR 667
S + E+D+ NN++ +L+ N +EQ K K D +K+ + + L+DE R
Sbjct: 330 SAIKELDTLNNEIVDLQREKNN----VEQDLKEKEDTIKQ------RTSEVQDLQDEVQR 379
Query: 668 KAKQGKENLWKENLRKEE-EEKQKRLQEEKTQ--EKIQEEERK-AEEKQRKDKDTLKAEE 723
+ NL K +K++ +E L E+K Q E+++E +K AEE Q +LKAE
Sbjct: 380 E----NTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL--ISSLKAEL 433
Query: 724 KKRET 728
+E+
Sbjct: 434 TSQES 438
Score = 38.1 bits (87), Expect = 0.072
Identities = 34/135 (25%), Positives = 61/135 (45%), Gaps = 9/135 (6%)
Query: 597 EQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELM 656
++LD L E E ++ LKE +T + ++ L + + +++ + +
Sbjct: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
Query: 657 QKKKLEDEAARKAKQGKENLWKENLRKEEEEKQ------KRLQEEKTQEKIQEEE--RKA 708
Q ++L DE + Q +E L KE +K EE Q L +++Q EEE +
Sbjct: 393 QVQELLDELDEQKAQLEEQL-KEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR 451
Query: 709 EEKQRKDKDTLKAEE 723
EE R ++T + EE
Sbjct: 452 EELSRLQQETAELEE 466
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 125 bits (314), Expect = 3e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 863 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 920
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 427 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 486
Query: 921 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 976
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 487 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 534
Query: 977 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1018
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 535 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 594
Query: 1019 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1078
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 595 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 649
Query: 1079 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1137
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 650 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 708
Query: 1138 WQGEINGVTGLFPSNYVK 1155
GE+ G +G+FP NY++
Sbjct: 709 MSGELMGKSGIFPKNYIQ 726
Score = 92.8 bits (229), Expect = 2e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 789 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 848
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 297 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 352
Query: 849 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 906
F V P P H + + + D++ +L+Q EN
Sbjct: 353 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 391
Query: 907 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 964
+ G G S +KII P E R P A + A ++V L+
Sbjct: 392 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 446
Query: 965 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1022
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 447 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 506
Query: 1023 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1080
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 507 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 561
Query: 1081 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1116
P + V+ P + T + + + A++ + A
Sbjct: 562 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 618
Query: 1117 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 619 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 657
Score = 78.6 bits (192), Expect = 5e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 1008 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1067
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 423 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 477
Query: 1068 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1120
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 478 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 532
Query: 1121 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1180
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 533 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 587
Query: 1181 RKRQ 1184
K++
Sbjct: 588 TKKE 591
Score = 73.6 bits (179), Expect = 2e-12
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 738 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 794
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 444 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 501
Query: 795 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 854
K ++ + V S E + + + VN W + R
Sbjct: 502 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 557
Query: 855 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 886
T + P V P+ G V +L A +AL S+TA+
Sbjct: 558 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 617
Query: 887 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 945
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 618 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 671
Query: 946 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1004
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 672 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 722
Query: 1005 NYVK 1008
NY++
Sbjct: 723 NYIQ 726
Score = 55.8 bits (133), Expect = 3e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 576
Query: 797 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 843
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 577 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 636
Query: 844 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 896
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 637 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 696
Query: 897 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 927
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 697 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 53.9 bits (128), Expect = 1e-06
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1102
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 380 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 434
Query: 1103 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1158
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 435 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 494
Query: 1159 D 1159
D
Sbjct: 495 D 495
Score = 46.6 bits (109), Expect = 2e-04
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 677 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 726
Score = 40.0 bits (92), Expect = 0.019
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 714
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 539 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 597
Query: 715 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 774
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 598 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 644
Query: 775 QGNFGWFPCNYVEKMPS-SENEKAVSPK 801
Q G FP +V P+ +++ A+ PK
Sbjct: 645 QDREGIFPAVFVRPCPAEAKSMLAIVPK 672
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 125 bits (314), Expect = 3e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 863 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 920
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 463 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 522
Query: 921 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 976
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 523 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 570
Query: 977 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1018
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 571 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 630
Query: 1019 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1078
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 631 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 685
Query: 1079 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1137
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 686 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 744
Query: 1138 WQGEINGVTGLFPSNYVK 1155
GE+ G +G+FP NY++
Sbjct: 745 MSGELMGKSGIFPKNYIQ 762
Score = 92.8 bits (229), Expect = 2e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 789 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 848
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
Query: 849 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 906
F V P P H + + + D++ +L+Q EN
Sbjct: 389 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 427
Query: 907 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 964
+ G G S +KII P E R P A + A ++V L+
Sbjct: 428 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 482
Query: 965 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1022
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 483 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 542
Query: 1023 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1080
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 543 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 597
Query: 1081 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1116
P + V+ P + T + + + A++ + A
Sbjct: 598 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 654
Query: 1117 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 655 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 693
Score = 78.6 bits (192), Expect = 5e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 1008 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1067
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 459 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 513
Query: 1068 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1120
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 514 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 568
Query: 1121 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1180
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 569 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 623
Query: 1181 RKRQ 1184
K++
Sbjct: 624 TKKE 627
Score = 73.6 bits (179), Expect = 2e-12
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 738 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 794
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 480 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 537
Query: 795 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 854
K ++ + V S E + + + VN W + R
Sbjct: 538 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 593
Query: 855 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 886
T + P V P+ G V +L A +AL S+TA+
Sbjct: 594 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 653
Query: 887 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 945
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 654 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 707
Query: 946 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1004
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 708 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 758
Query: 1005 NYVK 1008
NY++
Sbjct: 759 NYIQ 762
Score = 55.8 bits (133), Expect = 3e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 612
Query: 797 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 843
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 613 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 672
Query: 844 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 896
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 673 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 732
Query: 897 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 927
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 733 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 53.9 bits (128), Expect = 1e-06
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1102
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 416 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 470
Query: 1103 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1158
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 471 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 530
Query: 1159 D 1159
D
Sbjct: 531 D 531
Score = 46.6 bits (109), Expect = 2e-04
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 713 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 762
Score = 40.0 bits (92), Expect = 0.019
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 714
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 575 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 633
Query: 715 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 774
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 634 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 680
Query: 775 QGNFGWFPCNYVEKMPS-SENEKAVSPK 801
Q G FP +V P+ +++ A+ PK
Sbjct: 681 QDREGIFPAVFVRPCPAEAKSMLAIVPK 708
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 125 bits (314), Expect = 3e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 863 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 920
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 486 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 545
Query: 921 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 976
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 546 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 593
Query: 977 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1018
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 594 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 653
Query: 1019 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1078
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 654 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 708
Query: 1079 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1137
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 709 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 767
Query: 1138 WQGEINGVTGLFPSNYVK 1155
GE+ G +G+FP NY++
Sbjct: 768 MSGELMGKSGIFPKNYIQ 785
Score = 95.5 bits (236), Expect = 4e-19
Identities = 99/404 (24%), Positives = 171/404 (42%), Gaps = 57/404 (14%)
Query: 789 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 848
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
Query: 849 KSAFTR--TVSPGSVSPIHG-----QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL 901
F V P P H V + + + S + L+ + D++ +L
Sbjct: 389 SQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVS---QNPGELSCKRGDVLVML 445
Query: 902 EQQENWWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEY 959
+Q EN + G G S +KII P E R P A + A ++V
Sbjct: 446 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV---- 501
Query: 960 IALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGS 1017
L+ + + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+
Sbjct: 502 -VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
Query: 1018 ASKSGASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKR 1075
+ S+ K Y+ ++LS + G++I++ + W +GE++ R
Sbjct: 561 GKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR---- 616
Query: 1076 QKGWFPASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDY 1111
G FP + V+ P + T + + + A++ +
Sbjct: 617 -TGIFPLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSF 672
Query: 1112 AANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
A D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 673 TAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 716
Score = 80.5 bits (197), Expect = 1e-14
Identities = 66/264 (25%), Positives = 124/264 (46%), Gaps = 32/264 (12%)
Query: 937 PEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEE-ILVTQKDGEWWTGSI 995
P+ + +K S + + E I S PG+L+ G+ +++ Q + +
Sbjct: 403 PKPGHPLYSKYMLSVPHGIANEDIV-----SQNPGELSCKRGDVLVMLKQTENNYLECQK 457
Query: 996 GDRSG---IFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYV-----ASGSEQLSL 1047
G+ +G + + P D E S + +KP + A V A + L+L
Sbjct: 458 GEDTGRVHLSQMKIITPLD-EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNL 516
Query: 1048 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV 1102
G+++ +L+K + W++G + Q G FPA++VK++ G + +R + H V
Sbjct: 517 TSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCV 571
Query: 1103 --CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1160
+ +A ++Y +DELSFS+G++I + + +W +GE+ G TG+FP N+V+ D
Sbjct: 572 KGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDY 631
Query: 1161 DPSQQWCADLQTLDTMQPIERKRQ 1184
S L T P++ K++
Sbjct: 632 PTS-----GANVLSTKVPLKTKKE 650
Score = 73.6 bits (179), Expect = 2e-12
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 738 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 794
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 503 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
Query: 795 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 854
K ++ + V S E + + + VN W + R
Sbjct: 561 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 616
Query: 855 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 886
T + P V P+ G V +L A +AL S+TA+
Sbjct: 617 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 676
Query: 887 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 945
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 677 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 730
Query: 946 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1004
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 731 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 781
Query: 1005 NYVK 1008
NY++
Sbjct: 782 NYIQ 785
Score = 55.8 bits (133), Expect = 3e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 635
Query: 797 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 843
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 636 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 695
Query: 844 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 896
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 696 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 755
Query: 897 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 927
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 756 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 46.6 bits (109), Expect = 2e-04
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 785
Score = 40.0 bits (92), Expect = 0.019
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 714
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 598 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 656
Query: 715 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 774
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 657 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 703
Query: 775 QGNFGWFPCNYVEKMPS-SENEKAVSPK 801
Q G FP +V P+ +++ A+ PK
Sbjct: 704 QDREGIFPAVFVRPCPAEAKSMLAIVPK 731
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 120 bits (301), Expect = 1e-26
Identities = 92/353 (26%), Positives = 171/353 (48%), Gaps = 24/353 (6%)
Query: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
E RQ I+EL TE ++ L+++ +F +RM + + E+A +F N ELI +
Sbjct: 772 EIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNS 831
Query: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQKTD 1293
+A+ KK E ++ I D++ A Q +FCS Q L++ K
Sbjct: 832 WCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 888
Query: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
+++ F+ F+++ S P+C+ + L ++ MQR+T+YPLL+ SI+++T ++H L
Sbjct: 889 KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 948
Query: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---AEQLIFNSLTNCLGPRKLLH 1410
A ++ E+ VNE V++ EN RLE Q + L + L + L RK++H
Sbjct: 949 ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 1008
Query: 1411 SGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIF 1467
G L ++ +K +LH L D L+L + + K S+++ + + +
Sbjct: 1009 EGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSK-QTFSPVLK 1067
Query: 1468 LNEVLVKLPTDPSSDEPVFHISHIDR-----VYTLRTDNINERTAWVQKIKAA 1515
LN VL++ ++D+ F I + +Y L +++ W++ ++ A
Sbjct: 1068 LNAVLIR---SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEA 1117
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 120 bits (301), Expect = 1e-26
Identities = 92/353 (26%), Positives = 171/353 (48%), Gaps = 24/353 (6%)
Query: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
E RQ I+EL TE ++ L+++ +F +RM + + E+A +F N ELI +
Sbjct: 732 EIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNS 791
Query: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQKTD 1293
+A+ KK E ++ I D++ A Q +FCS Q L++ K
Sbjct: 792 WCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 848
Query: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
+++ F+ F+++ S P+C+ + L ++ MQR+T+YPLL+ SI+++T ++H L
Sbjct: 849 KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 908
Query: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---AEQLIFNSLTNCLGPRKLLH 1410
A ++ E+ VNE V++ EN RLE Q + L + L + L RK++H
Sbjct: 909 ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 968
Query: 1411 SGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIF 1467
G L ++ +K +LH L D L+L + + K S+++ + + +
Sbjct: 969 EGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSK-QTFSPVLK 1027
Query: 1468 LNEVLVKLPTDPSSDEPVFHISHIDR-----VYTLRTDNINERTAWVQKIKAA 1515
LN VL++ ++D+ F I + +Y L +++ W++ ++ A
Sbjct: 1028 LNAVLIR---SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEA 1077
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 118 bits (295), Expect = 5e-26
Identities = 129/550 (23%), Positives = 248/550 (45%), Gaps = 79/550 (14%)
Query: 341 NGTLPSYQKMQEEEPQKKLP-------VTFEDKRKANYERGNMELEKRRQALMEQQQREA 393
NG + S + QEEE ++ + EDK +A ER +E E+R + EQ ++ A
Sbjct: 230 NGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIA 289
Query: 394 ERKAQKEKEE----WERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIER--- 446
+ +A+ E EE ER++RE +E+E + E EKR ++R+ R +EEE+R ER
Sbjct: 290 DERARIEAEEKAAAQERERREAEERE--RMREEEKRAAEERQ--RIKEEEKRAAEERQRI 345
Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
+E K+ E ++R++ E R E + E+EE ++ +K+N LE + + +I
Sbjct: 346 KEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIK 405
Query: 507 GRLQDVRL--------KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEK 558
G + ++ K Q K + VL KQ + + +++ +++LQE + ++
Sbjct: 406 GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTF----KKE 461
Query: 559 QLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNN 618
++ +E+IK K KEE+ K +D + T K + +
Sbjct: 462 EIKDEKIK----------------KDKEPKEEV----KSFMDRKKGFTEVKSQNGEFMTH 501
Query: 619 QLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR----KAKQGKE 674
+LK T++ K + KRLE +++++ E E+ K KQ +
Sbjct: 502 KLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEA 561
Query: 675 NLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVN 734
L E L+K+ EE++K L+EE+ + K +E +RK E++ K + + E ++ E A
Sbjct: 562 ALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA----E 617
Query: 735 YRALYPFEARNHDEMSFN----SGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMP 790
R P + + D+ F G ++++E+ +L S Q + G V+
Sbjct: 618 KRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA----EFLNKSVQKSSG------VKSTH 667
Query: 791 SSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKS 850
+ + + + + ++ ++P +S+ P +N + + W+K +
Sbjct: 668 QAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRN-------IKSMWEKGN 720
Query: 851 AFTRTVSPGS 860
F+ + G+
Sbjct: 721 VFSSPTAAGT 730
Score = 72.4 bits (176), Expect = 3e-12
Identities = 89/384 (23%), Positives = 169/384 (44%), Gaps = 29/384 (7%)
Query: 363 FEDKRKANYE-RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLE 421
FE +R+ + R M LE R A Q+ + E +A +E+ R++R Q+QE + +
Sbjct: 4 FERRRELRRQKREEMRLEAERIAY--QRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 422 LEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEI 481
+ ++E + EE + + E RL RRQ+ L + Q+E
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 482 --------VRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLE 533
+ L S++ K ++ R + +++ T+ + D E
Sbjct: 122 DPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
Query: 534 IMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQ 593
+ + ++E +E + + E Q + ++ + ++ V L + EE Q
Sbjct: 182 ENKKEDKEKEEEEEEKPKRGSIGENQ-VEVMVEEKTTESQEETVVMSLKNGQISSEEPKQ 240
Query: 594 RLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEI--ERK 651
+ + + E K+ E D + + R L E+ +IK ++ K+I ER
Sbjct: 241 EEEREQGSDEISHHEKMEEEDKERAEAERAR-------LEAEERERIKAEQDKKIADERA 293
Query: 652 RLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE-----EKQKRLQEEKTQEKIQEEER 706
R+E +K ++ R+A++ +E + +E R EE E++KR EE+ + K +EE+R
Sbjct: 294 RIEAEEKAAAQERERREAEE-RERMREEEKRAAEERQRIKEEEKRAAEERQRIK-EEEKR 351
Query: 707 KAEEKQR-KDKDTLKAEEKKRETA 729
AEE+QR K+++ AEE++R A
Sbjct: 352 AAEERQRIKEEEKRAAEERQRARA 375
Score = 70.9 bits (172), Expect = 1e-11
Identities = 81/370 (21%), Positives = 171/370 (46%), Gaps = 27/370 (7%)
Query: 370 NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQ 429
++ER ++R+ + + +R A ++ ++EE R++R QE +Q + E+ L
Sbjct: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL--- 59
Query: 430 RELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKK 489
++ Q E + + EA Q + E + L ++ R Q+ + ++K
Sbjct: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
Query: 490 NLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQN 549
+ + S R+Q+ + +T + E + +Q E EI++ + + YQ
Sbjct: 120 --EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQ---ERYEIEETETVTKSYQ- 173
Query: 550 KLIYLVPEKQLLNERIKNMQFSNTPDSG-------VSLLHKKSLEKEELCQRLKEQLDAL 602
K + E+ ++ K + P G ++ +K+ E +E + + +
Sbjct: 174 KNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQI 233
Query: 603 EKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLE 662
E + E + ++++ + + ++ + +R +L+ ER+R++ Q KK+
Sbjct: 234 SSEEPKQEEEREQGSDEISH----HEKMEEEDKERAEAERARLEAEERERIKAEQDKKIA 289
Query: 663 DEAARKAKQGKENLWKENLRKEEEEKQKRLQEEK----TQEKIQEEE-RKAEEKQR-KDK 716
DE AR + K +E R+E EE+++ +EEK +++I+EEE R AEE+QR K++
Sbjct: 290 DERARIEAEEKAAA-QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEE 348
Query: 717 DTLKAEEKKR 726
+ AEE++R
Sbjct: 349 EKRAAEERQR 358
Score = 37.0 bits (84), Expect = 0.16
Identities = 48/199 (24%), Positives = 81/199 (40%), Gaps = 29/199 (14%)
Query: 626 TYNTQQLALEQLYKIKRDKLKEIER-KRL-ELMQKKKLEDEAARKAKQGKENLWKENLRK 683
T NTQ ++ ++R +E R KRL E ++++K D A + +N
Sbjct: 83 TTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTA 142
Query: 684 EEEEKQKRLQEEKTQEKIQEEE-------------RKAEEKQRKDKDTLKAEEKKRETAS 730
E E +K + E QE+ + EE R AEE +++DK+ + EE+K + S
Sbjct: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGS 202
Query: 731 VLVNYRALYPFEARNHDE-----MSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNY 785
+ N + E + MS +G I + K E G ++
Sbjct: 203 IGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE---------REQGSDEISH 253
Query: 786 VEKMPSSENEKAVSPKKAL 804
EKM + E+A + + L
Sbjct: 254 HEKMEEEDKERAEAERARL 272
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
sapiens]
Length = 927
Score = 114 bits (286), Expect = 6e-25
Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)
Query: 1154 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1213
+++ + P + TL ++ + KRQ I EL+ TE ++ L+++ ++F + MA
Sbjct: 403 LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 462
Query: 1214 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1273
E F E+ IF + ELI ++ L L R++ G ++ IGD+L A +
Sbjct: 463 ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 520
Query: 1274 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1327
RFCS Q L+ K +D F F+++ S PRC+ + L + MQR+
Sbjct: 521 SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 580
Query: 1328 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1387
T+YPLL++SI +NT E + ++LA E E+ VN+ VR+ E+ RL+ Q +
Sbjct: 581 TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 639
Query: 1388 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1441
L ++ ++ + +KL+H G L ++ +K E+H L +D LLL +
Sbjct: 640 SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 699
Query: 1442 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1501
+ + + + + + + + ++ TD + +F ++Y L
Sbjct: 700 LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 759
Query: 1502 INERTAW 1508
++ER W
Sbjct: 760 VSERKNW 766
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo
sapiens]
Length = 879
Score = 114 bits (286), Expect = 6e-25
Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)
Query: 1154 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1213
+++ + P + TL ++ + KRQ I EL+ TE ++ L+++ ++F + MA
Sbjct: 355 LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 414
Query: 1214 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1273
E F E+ IF + ELI ++ L L R++ G ++ IGD+L A +
Sbjct: 415 ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 472
Query: 1274 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1327
RFCS Q L+ K +D F F+++ S PRC+ + L + MQR+
Sbjct: 473 SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 532
Query: 1328 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1387
T+YPLL++SI +NT E + ++LA E E+ VN+ VR+ E+ RL+ Q +
Sbjct: 533 TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
Query: 1388 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1441
L ++ ++ + +KL+H G L ++ +K E+H L +D LLL +
Sbjct: 592 SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 651
Query: 1442 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1501
+ + + + + + + + ++ TD + +F ++Y L
Sbjct: 652 LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 711
Query: 1502 INERTAW 1508
++ER W
Sbjct: 712 VSERKNW 718
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo
sapiens]
Length = 912
Score = 114 bits (286), Expect = 6e-25
Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)
Query: 1154 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1213
+++ + P + TL ++ + KRQ I EL+ TE ++ L+++ ++F + MA
Sbjct: 388 LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 447
Query: 1214 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1273
E F E+ IF + ELI ++ L L R++ G ++ IGD+L A +
Sbjct: 448 ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 505
Query: 1274 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1327
RFCS Q L+ K +D F F+++ S PRC+ + L + MQR+
Sbjct: 506 SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 565
Query: 1328 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1387
T+YPLL++SI +NT E + ++LA E E+ VN+ VR+ E+ RL+ Q +
Sbjct: 566 TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 624
Query: 1388 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1441
L ++ ++ + +KL+H G L ++ +K E+H L +D LLL +
Sbjct: 625 SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 684
Query: 1442 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1501
+ + + + + + + + ++ TD + +F ++Y L
Sbjct: 685 LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 744
Query: 1502 INERTAW 1508
++ER W
Sbjct: 745 VSERKNW 751
>gi|194473700 Src homology 3 domain-containing guanine nucleotide
exchange factor [Homo sapiens]
Length = 871
Score = 112 bits (280), Expect = 3e-24
Identities = 75/272 (27%), Positives = 137/272 (50%), Gaps = 21/272 (7%)
Query: 1175 TMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELI 1234
T+ ERKRQ I E+I +E Y+ L++++ +F+ S +T+ E +F N ++
Sbjct: 432 TVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVC 491
Query: 1235 MSNTKLLKALRVRKKTGGEKMPVQMIGDILAAEL-SHMQAYIRFCSCQLNGAALLQQKTD 1293
++ K L R + + + I DI+ S Y+++C+ ++ LQ+
Sbjct: 492 EASKKFFIELEARHQNN---IFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLA 548
Query: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
+ FKE L ++ S C+ +P+ SFL+ PMQR+TR PLL+ +I + TP+ + K
Sbjct: 549 TNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKR 608
Query: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1413
AL+ +L NEG R+ E ++ + I + ++ + L+ +S R L+ G+
Sbjct: 609 ALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSS-------RWLVKRGE 661
Query: 1414 L----------YKTKSNKELHGFLFNDFLLLT 1435
L + S ++++ FLFND L++T
Sbjct: 662 LTAYVEDTVLFSRRTSKQQVYFFLFNDVLIIT 693
Score = 39.3 bits (90), Expect = 0.032
Identities = 19/70 (27%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 1017 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1076
S+ K A ++ ++ A ++LSL ++LI ++ + GW++GE R + +
Sbjct: 780 SSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGE---RLRDGE 836
Query: 1077 KGWFPASHVK 1086
+GWFP K
Sbjct: 837 RGWFPMECAK 846
Score = 32.7 bits (73), Expect = 3.0
Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 881 SWTAKKDNHLNFSKHDIITVLEQ-QENWWFGE--VHGGRGWFPKSYVKII 927
S+TAK+ + L+ D++ + ++ + W+ GE G RGWFP K I
Sbjct: 799 SFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEI 848
Score = 31.2 bits (69), Expect = 8.8
Identities = 21/79 (26%), Positives = 33/79 (41%), Gaps = 2/79 (2%)
Query: 1082 ASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE 1141
A + LG SS + + QV + + A DELS ++ + + W++GE
Sbjct: 771 ARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGE 830
Query: 1142 --INGVTGLFPSNYVKMTT 1158
+G G FP K T
Sbjct: 831 RLRDGERGWFPMECAKEIT 849
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 109 bits (272), Expect = 3e-23
Identities = 89/343 (25%), Positives = 159/343 (46%), Gaps = 28/343 (8%)
Query: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTD----SDP 1162
A++D+ ++ EL F G +I V+ + DWW G FP+++V++ + S+
Sbjct: 154 ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213
Query: 1163 SQQWCADLQTLDTMQPIERK-------RQGYIHELIQTEERYMADLQLVVEVFQKRMAE- 1214
S ++ Q + Q R R I E++ TE Y+ L+ + E + ++ +
Sbjct: 214 SSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKH 273
Query: 1215 SGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAY 1274
+G T ++A IF N +++ K LK L K+ E+ + IG Y
Sbjct: 274 TGMFTVAQLATIFGNIEDIYKFQRKFLKDLE--KQYNKEEPHLSEIGSCFLQNQEGFAIY 331
Query: 1275 IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLI 1334
+C+ GA L + ++ F + + + + FLL P+Q+I +YPL +
Sbjct: 332 SEYCNNH-PGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQL 390
Query: 1335 RSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRL-EWIQAHVQCEGLAEQ 1393
+L+ T + H D+S++K A E + + +NE R+ E+ D++ W + V EGL
Sbjct: 391 AELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGL--D 448
Query: 1394 LIFNSLTNCLGPRKLLHSGKLYK-TKSNKELHG--FLFNDFLL 1433
++ S +L+HSG+L K TK K FLF+ L+
Sbjct: 449 ILDRS-------SELIHSGELTKITKQGKSQQRTFFLFDHQLV 484
Score = 43.9 bits (102), Expect = 0.001
Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 14/121 (11%)
Query: 811 LSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPG----SVSPIHG 866
+ A++ SS+ +P+++ D N S + + Q A R + PG +++ +
Sbjct: 92 MRASNVSSD--GGTEPSALVD-DNGSEEDFSYEDLCQ---ASPRYLQPGGEQLAINELIS 145
Query: 867 QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLE-QQENWWFGEVHGGRGWFPKSYVK 925
G VV A+AL D L F D+I VLE ++WW+G WFP S+V+
Sbjct: 146 DGNVV---CAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR 202
Query: 926 I 926
+
Sbjct: 203 L 203
Score = 36.2 bits (82), Expect = 0.27
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 2/73 (2%)
Query: 961 ALYPYSSVEPGDLTFTEGEEILVTQKDG-EWWTGSIGDRSGIFPSNYVKPK-DQESFGSA 1018
AL+ + +++ +L F G+ I V + +WW G D+ FP+++V+ + +QE
Sbjct: 154 ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213
Query: 1019 SKSGASNKKPEIA 1031
S S S ++ E A
Sbjct: 214 SSSTPSEEQDEEA 226
Score = 34.7 bits (78), Expect = 0.80
Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 2/57 (3%)
Query: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSE 793
AL+ + E+ F +GD+IQV E W +G + WFP ++V + E
Sbjct: 154 ALWDHVTMDDQELGFKAGDVIQVLE--ASNKDWWWGRSEDKEAWFPASFVRLRVNQE 208
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 109 bits (272), Expect = 3e-23
Identities = 82/291 (28%), Positives = 137/291 (47%), Gaps = 26/291 (8%)
Query: 1169 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1228
+L LD + ERKRQ + E++ +E Y L ++VE F + +T+ E +F
Sbjct: 271 ELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFS 330
Query: 1229 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELS-HMQAYIRFCSCQLNGAAL 1287
N +++ ++ + + L R K ++ V+ I DIL H YI +CS ++
Sbjct: 331 NILDVLGASQRFFEDLEQRHKA---QVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRT 387
Query: 1288 LQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHAD 1347
LQ+ + F+E L+++ P C G+P+ SFL+ PMQR+TR PLL+ ++ T
Sbjct: 388 LQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSER 447
Query: 1348 HSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRK 1407
+ + AL+ +L Q NEG E +++ + + + SL R
Sbjct: 448 YKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV------KSLPLISASRW 501
Query: 1408 LLHSGKLY---------KTKSNKELHGFLFNDFLLLT-------YMVKQFA 1442
LL G+L+ K S + FLFND L++T YMV+ +A
Sbjct: 502 LLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDYA 552
Score = 38.5 bits (88), Expect = 0.055
Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 884 AKKDNHLNFSKHDIITVLEQQENWWFGE--VHGGRGWFPKSYVKII 927
AK+ + + + D++ VL+Q++ W +GE G GWFP+ + + I
Sbjct: 642 AKQADEVTLQQADVVLVLQQEDGWLYGERLRDGETGWFPEDFARFI 687
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 107 bits (267), Expect = 1e-22
Identities = 97/392 (24%), Positives = 203/392 (51%), Gaps = 30/392 (7%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRE 410
+EE+ +++ + +E + K + M ++ + E+ E E K +E EE +Q +
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI-RELEEKMHEQEK 405
Query: 411 LQEQEWKKQ-----LELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL-EWER 464
++EQE K+Q E EKR E++ ++ RQ E+ R ++ + RE K+ ++ ++ E E+
Sbjct: 406 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 465
Query: 465 IRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT--- 521
IR +E K +EQEE+ R K +H + E K + Q+ +++KQ +K
Sbjct: 466 IREEE----KRQEQEEMWRQEEK---IHEQEEIWRQKEKMHE---QEEKIRKQEEKVWRQ 515
Query: 522 ELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
E ++ +++ + E K +QE + + + ++ EK E+I + + +
Sbjct: 516 EEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ 575
Query: 582 HKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLAL-EQLYKI 640
+K E+EE R +E++ E++ + +M +++E E Q+ + EQ KI
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635
Query: 641 K-RDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQE 699
+ ++++ + + +++ ++K E E K ++ +E +W++ + E+EK+ R QEEK +E
Sbjct: 636 REQEEMTQEQEEKMGEQEEKMCEQE--EKMQEQEETMWRQEEKIREQEKKIREQEEKIRE 693
Query: 700 K---IQEEERK---AEEKQRKDKDTLKAEEKK 725
+ +QE+E K EEK + ++ ++ +E+K
Sbjct: 694 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 725
Score = 106 bits (265), Expect = 2e-22
Identities = 101/436 (23%), Positives = 216/436 (49%), Gaps = 36/436 (8%)
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPE-LVPPSFRGGKQIDSINGTLPSYQKMQEEEP 355
+++E+ + +++ ++ + + L LP + L + GK++ S++ L + +++E E
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQA--QVEENEL 290
Query: 356 QKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQE 415
+L E+K E+ EK Q+Q E R+ +++ E E K R +E
Sbjct: 291 WNRLNQQQEEKMWRQEEKIQEWEEKI------QEQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 416 WKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKN 475
W+K E+++ +Q E+ ++EE+ R+ E ++++ RQ + WE+ + L +K
Sbjct: 345 WEK----EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 400
Query: 476 REQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQK-TELEVLDKQCDLEI 534
EQE+I K++ E + Q+ Q+ ++++Q +K E E + + +I
Sbjct: 401 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKI 460
Query: 535 MEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQR 594
E +++++E + + + ++ EK E I + + +K ++EE R
Sbjct: 461 HEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK------EKMHEQEEKIRKQEEKVWR 514
Query: 595 LKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLE 654
+E++ E++ + +M +++E E + ++ EQ +K+ E E KR E
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ------EKIWE-EEKRQE 567
Query: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEE---KTQEKIQEEERKAEEK 711
K ++E K ++ +E +W++ + E+E++++ QEE K +EKI+E+E K +E+
Sbjct: 568 QEDKMWRQEE---KIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQ 624
Query: 712 QRKDKDTLKAEEKKRE 727
+ K ++ EEK RE
Sbjct: 625 EEKIRE---QEEKIRE 637
Score = 93.6 bits (231), Expect = 1e-18
Identities = 108/487 (22%), Positives = 219/487 (44%), Gaps = 85/487 (17%)
Query: 354 EPQKKLPVTFEDKRKANY-------ERGNMELEKRRQALMEQQQREAERKAQKEKE--EW 404
E ++ L K+KA+ ER + LE R + +++ +E K Q++ + E
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 235
Query: 405 ERKQRELQEQEWKKQLELEKRLEKQRELERQ-------------------REEERRKDIE 445
E+ + +L +E K++LE K L Q++L+ + E E +
Sbjct: 236 EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLN 295
Query: 446 RREAAKQELERQRRLEW-ERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL-----EALN 499
+++ K + ++ EW E+I+ QE +K REQEE +R +K E+ E +
Sbjct: 296 QQQEEKMWRQEEKIQEWEEKIQEQE---EKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352
Query: 500 GKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQE--YQNKLIYLVPE 557
+ + + + + +R +++ + E + +Q ++ + E ++ +EL+E ++ + I E
Sbjct: 353 RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM-MWEKEEKIRELEEKMHEQEKIREQEE 411
Query: 558 KQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELC-----------QRLKEQLDALEKET 606
K+ E+I+ + ++ + +K E+EE +++ EQ E+E
Sbjct: 412 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 471
Query: 607 ASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKR---------DKLKEIERKRLELMQ 657
+ EM ++ E E + ++ EQ KI++ +K++E E K E +
Sbjct: 472 RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEE 531
Query: 658 KKKLEDEAARKAKQ---------GKENLWKENLRKEEEEKQKRLQEE---------KTQE 699
K ++E R+ ++ +E +W+E R+E+E+K R +E+ + +E
Sbjct: 532 KMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEE 591
Query: 700 KIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQV 759
KI+E+E K +E++ K K EEK RE + + R +E ++ Q
Sbjct: 592 KIREQEEKRQEQEEK---MWKQEEKIREQEEKIQEQEE----KIREQEEKIREQEEMTQE 644
Query: 760 DEKTVGE 766
E+ +GE
Sbjct: 645 QEEKMGE 651
Score = 91.7 bits (226), Expect = 5e-18
Identities = 82/388 (21%), Positives = 188/388 (48%), Gaps = 41/388 (10%)
Query: 335 KQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAE 394
++I + + +K++E+E +++ ++ K + M ++ + E++ RE E
Sbjct: 391 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450
Query: 395 RKAQKEKE---EWERKQRELQEQEWKKQLELEKRLEKQRELERQREE--ERRKDIERREA 449
+K +++E E E+ + E + QE ++ E+++ +Q E+ RQ+E+ E+ + I ++E
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Query: 450 AKQELERQRRLEWERIRRQE----LLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQI 505
E + R + E+IR QE +K REQEE+ R K E + Q+
Sbjct: 511 KVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQED 570
Query: 506 SGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERI 565
Q+ ++++Q +K + +I++ +++ QE + K+ KQ E+I
Sbjct: 571 KMWRQEEKIREQEEKVWRQE---------EKIREQEEKRQEQEEKMW-----KQ--EEKI 614
Query: 566 KNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRE 625
+ + +K E+EE + +E++ E+ T + +M ++ E E
Sbjct: 615 REQE-------------EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEE 661
Query: 626 TYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEE 685
Q+ + + + R++ K+I + ++ +++++ E K + +E + ++ + +E
Sbjct: 662 KMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 721
Query: 686 EEKQKRLQEEKTQE---KIQEEERKAEE 710
+E++ R QEEK E +++++E K +E
Sbjct: 722 QEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 65.5 bits (158), Expect = 4e-10
Identities = 76/327 (23%), Positives = 145/327 (44%), Gaps = 47/327 (14%)
Query: 437 EEERRKDIERREAAKQELERQ-RRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL 495
E+E++ + +EA ++ELE Q + ++ EL Q + +L + ++L L
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 167
Query: 496 EALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEI-------KQLQQELQEYQ 548
++ L V +K+ +E L K+ D +E+ ++L+++ + Q
Sbjct: 168 HDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQ 227
Query: 549 NKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELC---QRLKEQLDALEKE 605
KL + EK + +K + K+ LE+ +L Q+L+ + D L KE
Sbjct: 228 EKLQLVESEKSEIQLNVKEL--------------KRKLERAKLLLPQQQLQAEADHLGKE 273
Query: 606 TAS---KLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLE 662
S KL N L + + E+ + +K++E E K E +K + +
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 663 DEAAR-----------KAKQGKENLW--KENLRKEEE-----EKQKRLQEEKTQEKIQEE 704
+E R K ++ +E +W +E +R++EE E++ R QEE EK +E+
Sbjct: 334 EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEK 392
Query: 705 ERKAEEKQRKDKDTLKAEEKKRETASV 731
R+ EEK + + + EEK++E +
Sbjct: 393 IRELEEKMHEQEKIREQEEKRQEEEKI 419
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 107 bits (267), Expect = 1e-22
Identities = 92/406 (22%), Positives = 202/406 (49%), Gaps = 41/406 (10%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEE-WER 406
+KM+EE+ ++ D+ + E + +++ E+ RE E K QK++E WE+
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQ--REEERRKDIERREAAKQELERQRRLE--- 461
+++E Q+Q +Q E EK +E E + +EE+ +D E ++++ RQ ++
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
Query: 462 ---WERIRRQELLNQKNREQEEIVRLNSKKKNLHL-ELEALNGKHQQISGRLQDVRLKKQ 517
WE+ + QK +QEE + ++++ + E + +++ R + +R +++
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 518 TQKTELEVLDKQCD-LEIMEIKQLQQE--LQEYQNKLIYLVPEKQLLNERIKNMQFSNTP 574
+ + E + +Q + ++ E K +QE +QE + K+ E+++ + K + P
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKM--WEQEEKMWEQEEKMWEQQRLP 661
Query: 575 DSGVSLLHKKSLEKEELCQRLKEQL---DALEKETAS---------KLSEMDSFNNQLKE 622
+ L + ++++E Q +E++ + +EK+T K+ E +S + K+
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721
Query: 623 LRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLR 682
+RE E++ + + +K++E E K E ++ ++E K + +E +W++
Sbjct: 722 MREE--------EEMMREQEEKMQEQEEKMQEQEEEMWEQEE---KMWEQEEKMWEQQRL 770
Query: 683 KEEEEKQKRLQEEKTQEKIQEEERK---AEEKQRKDKDTLKAEEKK 725
E++EK ++ + QEKI E+E K EEK R ++ ++ +E+K
Sbjct: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEK 816
Score = 105 bits (263), Expect = 3e-22
Identities = 99/448 (22%), Positives = 222/448 (49%), Gaps = 40/448 (8%)
Query: 349 KMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE-EWERK 407
KM+E+E + + ++KR E+ E EK + E +++E + + Q+EK E E K
Sbjct: 308 KMREQEEK----MWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEK 363
Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE--WERI 465
RE +E+ W+++ L ++ ++ RE E++ ++ + E+ E +++ ER R E WE++
Sbjct: 364 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQV 423
Query: 466 ------RRQELLNQKNREQEEIV----RLNSKKKNLHLELEALNGKHQQISGRLQDV--R 513
++ + +K R+QEE + R+ ++K + E E + + +++ + +++ +
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483
Query: 514 LKKQTQKTEL----EVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
+K+ Q+ L E L +Q ++ E K +QE + + ++ +K E+++ +
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQE 543
Query: 570 FSN-TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYN 628
+ + +K ++EE ++ ++ + + K+ E + + K++RE
Sbjct: 544 DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 629 TQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA----RKAKQGKENLWKENLRKE 684
+ E++ + + +K++E E K E +K + ++E K + +E +W++ E
Sbjct: 604 MMREQEEKMQE-QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
Query: 685 EEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAE------EKKRETASVLVNYRAL 738
++EK ++ + QEK+QE+E K E+++ +K T + E EK RE S+ + +
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKM 722
Query: 739 YPFEARNHDEMSFNSGDIIQVDEKTVGE 766
R +EM + +Q E+ + E
Sbjct: 723 -----REEEEMMREQEEKMQEQEEKMQE 745
Score = 102 bits (255), Expect = 2e-21
Identities = 96/410 (23%), Positives = 206/410 (50%), Gaps = 54/410 (13%)
Query: 349 KMQEEEPQKKLPVTFEDKRKA--NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
K + E Q+KLP+ +K + N + +LE+ + L + Q + + +++EE
Sbjct: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 283
Query: 407 KQRELQEQE---WKKQLEL-----------------EKRLEKQRELERQREEERRKDIER 446
+++++++QE W+++ L EKRL +Q + R++E+E R+ E
Sbjct: 284 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKEL 343
Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
RE +Q E++ ++ WE+ + +K QEE RL ++K + + + + + +++
Sbjct: 344 REQEEQMQEQEEKM-WEQEEKMREQEEKMWRQEE--RLWEQEKQMREQEQKMRDQEERMW 400
Query: 507 GRLQDVRLK-KQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERI 565
QD RL+ K+ + E E + +Q + ++ E K++Q++ ++ +++ EK ERI
Sbjct: 401 E--QDERLREKEERMREQEKMWEQVE-KMREEKKMQEQEKKTRDQ-----EEKMQEEERI 452
Query: 566 KNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRE 625
+ + KK E+EE + +E++ ++E + E + +L E +E
Sbjct: 453 RERE-------------KKMREEEETMREQEEKMQK-QEENMWEQEEKEWQQQRLPEQKE 498
Query: 626 TYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEE 685
Q+ EQ KI + K +++ + +KK E K ++ ++ +W++ + +
Sbjct: 499 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE---KMREQEDQMWEQEEKMRD 555
Query: 686 EEKQKRLQEEKTQEKIQEEERKA---EEKQRKDKDTLKAEEKKRETASVL 732
+E++ QEE+ ++K QE+E+K EEK R+++ + E+K RE ++
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 605
Score = 102 bits (254), Expect = 3e-21
Identities = 99/443 (22%), Positives = 204/443 (46%), Gaps = 43/443 (9%)
Query: 343 TLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE 402
TL QEEE + E ++K + M ++ R E + RE E K ++++
Sbjct: 269 TLQEEMWRQEEELR-------EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321
Query: 403 EWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
+++EL+EQE K+L +K L +Q E +++EE+ + E+ ++++ RQ W
Sbjct: 322 RLREQEKELREQE--KELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379
Query: 463 ERIRRQELLNQKNREQEEIV-----RLNSKKKNLHLE---LEALNGKHQQISGRLQDVRL 514
E+ ++ QK R+QEE + RL K++ + + E + ++ + Q+ +
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 515 KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP 574
+ Q +K + E ++ + ++ E ++ +E +E K E+ + + K Q P
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQK-----QEENMWEQEEKEWQQQRLP 494
Query: 575 DSGVSLLHKKSLEKEELCQRLKEQLDAL--------EKETASKLSEMDSFNNQLKELRET 626
+ L ++ ++++E +++ EQ + + +++ + +M +Q+ E E
Sbjct: 495 EQKEKLWEQEKMQEQE--EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552
Query: 627 YNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE 686
Q+ + + K +E E+K + +K + E+ + K+ +E +E + +E+E
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMRE---EEEMMREQE 609
Query: 687 EKQKRLQEEKTQ---EKIQEEERKAEEKQRK----DKDTLKAEEKKRETASVLVNYRALY 739
EK + QEEK Q EK+ E+E K +E++ K ++ + EEK E + L+
Sbjct: 610 EKMQE-QEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668
Query: 740 PFEARNHDEMSFNSGDIIQVDEK 762
E E + I EK
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQEK 691
Score = 100 bits (248), Expect = 2e-20
Identities = 92/395 (23%), Positives = 198/395 (50%), Gaps = 25/395 (6%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWE----- 405
QEE+ ++ +E +++ + M ++ R +++ RE E + +++++ WE
Sbjct: 367 QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKM 426
Query: 406 RKQRELQEQEWKKQLELEKRLEKQRELERQR-----EEERRKDIERREAAKQELERQRRL 460
R+++++QEQE K + + EK E++R ER++ EE R+ E+ + ++ + Q
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486
Query: 461 EWERIR----RQELLNQ-KNREQEEIVRLNSKKKNLHLELEALNGKH-QQISGRLQDVRL 514
EW++ R +++L Q K +EQEE + +K E+ K +Q R Q+ ++
Sbjct: 487 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 546
Query: 515 KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP 574
+Q +K + E ME K +QE + + + + E++ + ER K M+
Sbjct: 547 WEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQE--EKMREEERMREREKKMR---EE 601
Query: 575 DSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLAL 634
+ + +K E+EE Q +E++ E++ + +M ++ E E QQ
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 635 EQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE---EKQKR 691
EQ K+ + + + K E +K +++ +K ++ ++ W + +EEE E++K+
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721
Query: 692 LQEEKTQEKIQEEE-RKAEEKQRKDKDTLKAEEKK 725
++EE+ + QEE+ ++ EEK ++ ++ + +E+K
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEK 756
Score = 98.6 bits (244), Expect = 4e-20
Identities = 90/408 (22%), Positives = 209/408 (51%), Gaps = 34/408 (8%)
Query: 347 YQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW-E 405
+++ ++E Q++LP E K K +E+ M+ ++ + E++ R+ E +EK+ W +
Sbjct: 481 WEQEEKEWQQQRLP---EQKEKL-WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ 536
Query: 406 RKQRELQEQEWKKQLEL----EKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE 461
K RE ++Q W+++ ++ +K +++ +E++ +E+ +K ++ E ++E ER R E
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREE-ERMRERE 595
Query: 462 WERIRRQELLN-QKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQK 520
+ +E++ Q+ + QE+ ++ +++ + + E + + +++ + + + +++
Sbjct: 596 KKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMW 655
Query: 521 TELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM--QFSNTPDSGV 578
+ + +++ L E Q Q+++QE + K+ ++ E+ K Q + +
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM 715
Query: 579 SLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLY 638
KK E+EE+ + +E++ E++ + EM ++ E E QQ EQ
Sbjct: 716 REREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Query: 639 KI-------KRDKLKEIERKRLELMQKKKLEDEAAR----KAKQGKENLW--KENLRKEE 685
K+ +++K+ E E K + +K + ++E R K + +E +W +E + +E
Sbjct: 776 KLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQE 835
Query: 686 E-----EKQKRLQEEKTQEKIQEEE---RKAEEKQRKDKDTLKAEEKK 725
E E++ QEEK +EK+Q +E R+ EEK R ++ ++ +E+K
Sbjct: 836 EKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEK 883
Score = 94.7 bits (234), Expect = 6e-19
Identities = 97/369 (26%), Positives = 188/369 (50%), Gaps = 56/369 (15%)
Query: 372 ERGNMELEKRRQALMEQQ--QREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQ 429
ER + LE R + ++ ++ AE + + E E+ + +L +E K++LE K L Q
Sbjct: 205 ERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQ 264
Query: 430 RELERQREEERRKDIERREAAKQELERQRRLEW---ERIRRQELLNQKNREQEEIVRLNS 486
+ +EE R++ E RE K+ + +Q W ER+R QE K REQEE +
Sbjct: 265 VQTNTLQEEMWRQEEELREQEKK-IRKQEEKMWRQEERLREQE---GKMREQEEKMWRQE 320
Query: 487 KKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQE 546
K+ L + +++ + +++R +K+ ++ E ++ +++ + E K +QE +
Sbjct: 321 KR---------LREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKM 371
Query: 547 YQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKET 606
++ + EKQ+ + +K ++EE R+ EQ + L +E
Sbjct: 372 WRQEERLWEQEKQMREQ------------------EQKMRDQEE---RMWEQDERL-REK 409
Query: 607 ASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA 666
++ E + Q++++RE Q+ E+ + + +K++E ER R E +K + E+E
Sbjct: 410 EERMREQEKMWEQVEKMREEKKMQE--QEKKTRDQEEKMQEEERIR-EREKKMREEEETM 466
Query: 667 R----KAKQGKENLWKENLRKEEEEKQKRLQEEK----TQEKIQEEERKAEEKQRK--DK 716
R K ++ +EN+W++ +E+E +Q+RL E+K QEK+QE+E K E++ K D+
Sbjct: 467 REQEEKMQKQEENMWEQ---EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523
Query: 717 DTLKAEEKK 725
+ + +EKK
Sbjct: 524 EEMWGQEKK 532
Score = 74.7 bits (182), Expect = 7e-13
Identities = 75/314 (23%), Positives = 152/314 (48%), Gaps = 32/314 (10%)
Query: 427 EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNS 486
E QR L ++ D E K+ L I +EL + QE++ S
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
Query: 487 KKKNLHLELEALNGKHQQISGRLQDVR---LKKQTQKTELEVLDKQCDLEIMEIKQLQQE 543
+K + L ++ L K ++ L V+ L+++ + E E+ +++ + E K +QE
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299
Query: 544 --LQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDA 601
L+E + K+ + +R++ + K L ++E + L+EQ +
Sbjct: 300 ERLREQEGKMREQEEKMWRQEKRLREQE--------------KELREQE--KELREQKEL 343
Query: 602 LEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKL 661
E+E + E + Q +++RE E+L++ + +++E E+K + ++
Sbjct: 344 REQEEQMQEQE-EKMWEQEEKMREQEEKMWRQEERLWE-QEKQMREQEQKMRDQEERMWE 401
Query: 662 EDEAARKAKQ---GKENLWKENLRKEEEEKQKRLQEEKT---QEKIQEEE--RKAEEKQR 713
+DE R+ ++ +E +W E + K EEK+ + QE+KT +EK+QEEE R+ E+K R
Sbjct: 402 QDERLREKEERMREQEKMW-EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
Query: 714 KDKDTLKAEEKKRE 727
++++T++ +E+K +
Sbjct: 461 EEEETMREQEEKMQ 474
Score = 68.9 bits (167), Expect = 4e-11
Identities = 83/384 (21%), Positives = 169/384 (44%), Gaps = 95/384 (24%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+KM+EEE + ++++ E E E++ E+ Q + E+ ++E++ WE++
Sbjct: 596 KKMREEEEMMRE----QEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 651
Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW--ERI 465
++ ++Q +Q E EK +E E+ +E+E + I +E +++ + Q + W E++
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK--IWEQEKMEKKTQEQEKKTWDQEKM 709
Query: 466 RRQELLNQ---KNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
R +E + + K RE+EE++R +K +Q+ K Q Q+ E
Sbjct: 710 REEESMREREKKMREEEEMMREQEEK--------------------MQEQEEKMQEQEEE 749
Query: 523 L-EVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
+ E +K + E E QQ L E + KL
Sbjct: 750 MWEQEEKMWEQE--EKMWEQQRLPEQKEKL----------------------------WE 779
Query: 582 HKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIK 641
H+K E+E++ ++ ++ D EK E+ + +
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQ--------------------------EEKMRGQ 813
Query: 642 RDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKI 701
+K++ E K +K ++E K +E +W + +E+ E++ + QEEK +E+
Sbjct: 814 EEKMRGQEEKMWGQEEKMWGQEE---KMWGQEEKMWGQ---EEKMEEKMQGQEEKMREQ- 866
Query: 702 QEEERKAEEKQRKDKDTLKAEEKK 725
+E+ R EEK R+ ++ ++ +E+K
Sbjct: 867 EEKMRGQEEKMREQEEKMRGQEEK 890
Score = 65.1 bits (157), Expect = 6e-10
Identities = 58/233 (24%), Positives = 124/233 (53%), Gaps = 32/233 (13%)
Query: 347 YQKMQEEE----------PQKKLPVTFEDKRKANYERGNMELE---KRRQALM---EQQQ 390
++KMQE+E Q+K+ +++ K +++ M E + R+ M E+
Sbjct: 670 HEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729
Query: 391 REAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQRE--------EERRK 442
RE E K Q+++E+ + ++ E+ EQE +K E E+++ +Q+ L Q+E +E+ K
Sbjct: 730 REQEEKMQEQEEKMQEQEEEMWEQE-EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Query: 443 DIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKH 502
E+ E + + E+ R E E++R QE +K R QEE ++ +++ + + E + G+
Sbjct: 789 IWEQEEKMRDQEEKMRGQE-EKMRGQE---EKMRGQEE--KMWGQEEKMWGQEEKMWGQE 842
Query: 503 QQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLV 555
+++ G+ + + K Q Q+ ++ +++ + ++++ Q+E Q + IY V
Sbjct: 843 EKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMRE-QEEKMRGQEEKIYCV 894
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
sapiens]
Length = 532
Score = 107 bits (267), Expect = 1e-22
Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)
Query: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
E KRQ I EL Q EE + DL+L + + M + +TE E+ IF LI + +
Sbjct: 126 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 185
Query: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1299
LL LR +K G + +G IL L + +Y +CS Q+ ALL K +D +
Sbjct: 186 LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 241
Query: 1300 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1359
+FL++ P + + L +FL P R+ +YPLL+R IL +TP + D L+ A+ +
Sbjct: 242 DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 301
Query: 1360 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1416
+ +++N E E +RL +++ EG + LI +S R L G+L K
Sbjct: 302 GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 348
Query: 1417 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1474
+LH FLF + L++T V + +E+L +++Y+ PI + ++L++
Sbjct: 349 NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 393
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
sapiens]
Length = 558
Score = 107 bits (267), Expect = 1e-22
Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)
Query: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
E KRQ I EL Q EE + DL+L + + M + +TE E+ IF LI + +
Sbjct: 152 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 211
Query: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1299
LL LR +K G + +G IL L + +Y +CS Q+ ALL K +D +
Sbjct: 212 LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 267
Query: 1300 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1359
+FL++ P + + L +FL P R+ +YPLL+R IL +TP + D L+ A+ +
Sbjct: 268 DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 327
Query: 1360 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1416
+ +++N E E +RL +++ EG + LI +S R L G+L K
Sbjct: 328 GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 374
Query: 1417 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1474
+LH FLF + L++T V + +E+L +++Y+ PI + ++L++
Sbjct: 375 NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 419
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 107 bits (267), Expect = 1e-22
Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)
Query: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
E KRQ I EL Q EE + DL+L + + M + +TE E+ IF LI + +
Sbjct: 120 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 179
Query: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1299
LL LR +K G + +G IL L + +Y +CS Q+ ALL K +D +
Sbjct: 180 LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 235
Query: 1300 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1359
+FL++ P + + L +FL P R+ +YPLL+R IL +TP + D L+ A+ +
Sbjct: 236 DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 295
Query: 1360 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1416
+ +++N E E +RL +++ EG + LI +S R L G+L K
Sbjct: 296 GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 342
Query: 1417 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1474
+LH FLF + L++T V + +E+L +++Y+ PI + ++L++
Sbjct: 343 NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 387
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 106 bits (264), Expect = 2e-22
Identities = 96/411 (23%), Positives = 203/411 (49%), Gaps = 38/411 (9%)
Query: 343 TLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKE 402
TL QEEE + E ++K + M ++ R E + RE E K +++++
Sbjct: 231 TLQEEMWRQEEELR-------EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEK 283
Query: 403 EWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
+++EL+EQE K+L +K+L +Q E +++EE+ + E+ ++++ RQ W
Sbjct: 284 RLREQEKELREQE--KELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341
Query: 463 ERIRRQELLNQKNREQEEIV-----RLNSKKKNLH-----LELEALNGKHQQISGRLQDV 512
E+ ++ QK R+QEE + RL K++ + E E + ++I R + +
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKM 401
Query: 513 RLKKQTQKTELEVLDKQCD-LEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFS 571
R +++T + + E + KQ + + E K+ QQ+ Q + ++ + Q E+I +
Sbjct: 402 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461
Query: 572 NTPDSGVSLLHKKSLEKEELCQR------LKEQLDALEKETASKLSEMDSFNNQLKELRE 625
+ KK +E++ ++ +E++ E++ + M + +L+E E
Sbjct: 462 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEE 521
Query: 626 TYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR----KAKQGKENLWKENL 681
Q+ +Q K++ +K + + K+ ++K E+E R K ++ +E + ++
Sbjct: 522 RMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 581
Query: 682 RKEEEEKQKRLQEEK---TQEKIQEEERKAEEKQRK-----DKDTLKAEEK 724
+ +E+E++ R QEEK +EK+QE+E K E++ K ++D ++ +E+
Sbjct: 582 KMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEE 632
Score = 106 bits (264), Expect = 2e-22
Identities = 97/411 (23%), Positives = 200/411 (48%), Gaps = 51/411 (12%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQ------------ 398
QEE+ Q++ +E + K + M ++ R E+Q RE E+K +
Sbjct: 308 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 367
Query: 399 -KEKEEWERKQRELQEQEWKKQ-----LELEKRLEKQRELERQREEERRK------DIER 446
+EKEE R+Q ++ EQE K Q E EK++ ++ E R++EE+ +K + E
Sbjct: 368 LREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 427
Query: 447 REAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
+E +Q L Q+ WE+ + QE +K EQEE +R + E + G+ +++
Sbjct: 428 KEWQQQRLPEQKEKLWEQEKMQEQ-EEKIWEQEEKIR----------DQEEMWGQEKKMW 476
Query: 507 GRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIK 566
+ + + Q + E ++ D++ + E + +Q+ + + K + +K++ + K
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQD-ERLREKEERMREQKKMWQQEEK 535
Query: 567 NMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRET 626
+ T + ++ +EE +R++E+ + +E + + Q +++RE
Sbjct: 536 MREEKKTQEQEKKTWDQEEKMREE--ERMREREKKMREEEEMMREQEEKMQEQEEKMREQ 593
Query: 627 YNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLED------EAARKAKQGKENLWKEN 680
+ E+ + + +K+ E E K E ++ K+++ E K ++ +E +W++
Sbjct: 594 -EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQE 652
Query: 681 LRKEEEEKQKRLQEEKTQ---EKIQEEERK---AEEKQRKDKDTLKAEEKK 725
+ E+E++ R QEEK Q EK++E+E K EEK R+ ++ ++ +E+K
Sbjct: 653 EKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEK 703
Score = 103 bits (256), Expect = 2e-21
Identities = 105/422 (24%), Positives = 212/422 (50%), Gaps = 64/422 (15%)
Query: 349 KMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQ-REAERKAQKEKE---EW 404
KM+E+E + + ++KR E+ EL ++ + L EQ++ RE E + Q+++E E
Sbjct: 270 KMREQEEKMRR----QEKRLREQEK---ELREQEKELREQKKLREQEEQMQEQEEKMWEQ 322
Query: 405 ERKQRELQEQEWKKQLEL---EKRLEKQRELERQREEE--------RRKDIERREAAKQE 453
E K RE +E+ W+++ L EK++ +Q + R +EE R K+ RE K
Sbjct: 323 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382
Query: 454 LERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLH----LELEALNGKHQQISGRL 509
+ ++ E ERIR +E +K RE+EE +R +K E E + Q++ +
Sbjct: 383 EQEEKMQEEERIRERE---KKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK 439
Query: 510 QDVRLKKQTQKTELEVLDKQ---CDLEIM---EIKQLQQELQEYQNKLIYLVPEK----- 558
+ + +++ Q+ E ++ +++ D E M E K +QE Q ++ EK
Sbjct: 440 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 499
Query: 559 QLLNERIKNM--QFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKET---ASKLSEM 613
Q + ++ + M Q + + +K + ++E R +++ EK+T K+ E
Sbjct: 500 QKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE 559
Query: 614 DSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGK 673
+ + K++RE E++ + + +K++E E K E +K ++E K ++ +
Sbjct: 560 ERMREREKKMREE--------EEMMREQEEKMQEQEEKMREQEEKMWEQEE---KMQEQE 608
Query: 674 ENLWKENLRKEEEEKQKRLQEEKT-----QEKIQEEERKA---EEKQRKDKDTLKAEEKK 725
E +W++ + E+E++ ++QE++ +EK+QE+E K EEK R+ ++ ++ +E+K
Sbjct: 609 EKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEK 668
Query: 726 RE 727
+
Sbjct: 669 MQ 670
Score = 97.4 bits (241), Expect = 1e-19
Identities = 92/401 (22%), Positives = 199/401 (49%), Gaps = 48/401 (11%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEE-WERKQR 409
++EE ++ +E + K E E EK+ + E+ RE E K QK++E WE++++
Sbjct: 370 EKEERMREQEKMWEQEEKMQEEERIREREKKMRE-EEETMREQEEKMQKQEENMWEQEEK 428
Query: 410 ELQEQEWKKQLELEKRLEKQRELERQ--REEERRKDIERREAAKQELERQRRLE------ 461
E Q+Q +Q E EK +E E + +EE+ +D E ++++ RQ ++
Sbjct: 429 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM 488
Query: 462 WE-----RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKK 516
WE R + Q++ +Q+ R E+ RL K++ + + +++ + + +R +K
Sbjct: 489 WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMR--------EQKKMWQQEEKMREEK 540
Query: 517 QTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDS 576
+TQ+ E + D++ E + ++ ++E + K+ E++++ E+ + MQ +
Sbjct: 541 KTQEQEKKTWDQE------EKMREEERMREREKKMR---EEEEMMREQEEKMQ---EQEE 588
Query: 577 GVSLLHKKSLEKEELCQRLKEQL-----DALEKETASKLSEMDSFNNQLKELRETYNTQQ 631
+ +K E+EE Q +E++ E+E K+ E + + +E + +
Sbjct: 589 KMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKM 648
Query: 632 LALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE----- 686
E+ + + +K++E E K ++ ++K E E + ++ K +E +R +EE
Sbjct: 649 WEQEEKMREQEEKMREQEEK-MQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQ 707
Query: 687 EKQKRLQEEKT--QEKIQEEERKAEEKQRKDKDTLKAEEKK 725
E++ QEEK QE+++E+E + +++ K ++ L E++
Sbjct: 708 EEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEER 748
Score = 96.3 bits (238), Expect = 2e-19
Identities = 90/393 (22%), Positives = 192/393 (48%), Gaps = 18/393 (4%)
Query: 361 VTFEDKRKANYE-RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRE-LQEQEWKK 418
+T E+ +K N E + + L + ++ ++ +E +RK ++ K + Q LQE+ W++
Sbjct: 180 ITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 239
Query: 419 QLEL---EKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKN 475
+ EL EK++ KQ E + R+EER ++ +E +E E + R + +R+R QE ++
Sbjct: 240 EEELREQEKKIRKQEE-KMWRQEERLRE---QEGKMREQEEKMRRQEKRLREQE---KEL 292
Query: 476 REQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIM 535
REQE+ +R K + +++ K + ++++ K Q+ L +KQ +
Sbjct: 293 REQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 352
Query: 536 EIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRL 595
+++ ++ + E Q++ + E+ E++ + + + KK E+EE +
Sbjct: 353 KMRDQEERMWE-QDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQ 411
Query: 596 KEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLEL 655
+E++ ++E + E + +L E +E Q+ EQ KI + K +++ +
Sbjct: 412 EEKMQK-QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470
Query: 656 MQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKD 715
+KK E K ++ ++ +W++ + ++E++ QEE+ E+ E R+ EE+ R+
Sbjct: 471 QEKKMWRQE---KMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ-DERLREKEERMREQ 526
Query: 716 KDTLKAEEKKRETASVLVNYRALYPFEARNHDE 748
K + EEK RE + + E + +E
Sbjct: 527 KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE 559
Score = 95.9 bits (237), Expect = 3e-19
Identities = 103/408 (25%), Positives = 213/408 (52%), Gaps = 41/408 (10%)
Query: 349 KMQEEEPQKKLPVTFEDKRKA--NYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
K + E Q+KL + +K + N + +LE+ + L + Q + + +++EE
Sbjct: 186 KKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 245
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL-EWERI 465
+++++++QE K + E+ E++ ++ Q E+ RR++ RE K+ E+++ L E +++
Sbjct: 246 QEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKL 305
Query: 466 RRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEV 525
R QE ++ +EQEE ++ +++ + + E + + +++ + + +R ++Q + + E
Sbjct: 306 REQE---EQMQEQEE--KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 360
Query: 526 LDKQCD--LEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM-QFSNTPDSGVSLLH 582
+ +Q + E E + Q+++ E + K+ E++ + ER K M + T +
Sbjct: 361 MWEQDERLREKEERMREQEKMWEQEEKM----QEEERIREREKKMREEEETMREQEEKMQ 416
Query: 583 K------KSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQ 636
K + EKE QRL EQ KE + +M ++ E E Q+ Q
Sbjct: 417 KQEENMWEQEEKEWQQQRLPEQ-----KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 471
Query: 637 LYKI-KRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWK--ENLRKEEE--EKQKR 691
K+ +++K++E E + E Q++K+ D+ + Q +E +W+ E LR++EE +QK+
Sbjct: 472 EKKMWRQEKMREQEDQMWE--QEEKMRDQEQKMWDQ-EERMWEQDERLREKEERMREQKK 528
Query: 692 L--QEEKTQE--KIQEEERKA---EEKQRKDKDTLKAEEKKRETASVL 732
+ QEEK +E K QE+E+K EEK R+++ + E+K RE ++
Sbjct: 529 MWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMM 576
Score = 90.1 bits (222), Expect = 2e-17
Identities = 90/362 (24%), Positives = 182/362 (50%), Gaps = 42/362 (11%)
Query: 372 ERGNMELEKRRQALMEQQ--QREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQ 429
ER + LE R + ++ ++ AE + + E E+ + +L +E K++LE K L Q
Sbjct: 167 ERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQ 226
Query: 430 RELERQREEERRKDIERREAAKQELERQRRLEW---ERIRRQELLNQKNREQEEIVRLNS 486
+ +EE R++ E RE K+ + +Q W ER+R QE K REQEE +R
Sbjct: 227 VQTNTLQEEMWRQEEELREQEKK-IRKQEEKMWRQEERLREQE---GKMREQEEKMRRQE 282
Query: 487 KKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQE 546
K+ L + +++ + +++R +K+ ++ E ++ +++ + E K +QE +
Sbjct: 283 KR---------LREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKM 333
Query: 547 YQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKET 606
++ + EKQ+ + Q + + ++ EKEE R++EQ E+E
Sbjct: 334 WRQEERLWEQEKQMREQE----QKMRDQEERMWEQDERLREKEE---RMREQEKMWEQE- 385
Query: 607 ASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAA 666
K+ E + + K++RE T + E++ K + + ++ E++ Q+++L ++
Sbjct: 386 -EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE----WQQQRLPEQ-- 438
Query: 667 RKAKQGKENLWKENLRKEEEEKQKRLQEE-KTQEKIQEEERK--AEEKQRKDKDTLKAEE 723
KE LW++ +E+EEK +E+ + QE++ +E+K +EK R+ +D + +E
Sbjct: 439 ------KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 492
Query: 724 KK 725
+K
Sbjct: 493 EK 494
Score = 80.5 bits (197), Expect = 1e-14
Identities = 93/386 (24%), Positives = 181/386 (46%), Gaps = 61/386 (15%)
Query: 364 EDKRKANYE-----RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKK 418
ED++KA+++ R +E + ++ Q+ E E ++ R+ ++ +
Sbjct: 70 EDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDA----ARKFEDGNLGE 125
Query: 419 QLELEKRL--------EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQEL 470
+L RL E QR L ++ D E K+ L I +EL
Sbjct: 126 SKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEEL 185
Query: 471 LNQKNREQEEIVRL-NSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQ 529
+KN E +E +RL S+K + L ++ L K ++ L V QT + E+ ++
Sbjct: 186 -KKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQV----QTNTLQEEMWRQE 240
Query: 530 CDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKE 589
+L E K +QE + ++ + ER++ + K E+E
Sbjct: 241 EELREQEKKIRKQEEKMWRQE------------ERLREQE-------------GKMREQE 275
Query: 590 ELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIE 649
E +R +++L EKE L E + + K+LRE Q E++++ + +K++E E
Sbjct: 276 EKMRRQEKRLREQEKE----LREQEKELREQKKLREQEEQMQEQEEKMWE-QEEKMREQE 330
Query: 650 ----RKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEE--KTQEKIQE 703
R+ L +++K E +K + +E +W+++ R E+E++ R QE+ + +EK+QE
Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE 390
Query: 704 EE--RKAEEKQRKDKDTLKAEEKKRE 727
EE R+ E+K R++++T++ +E+K +
Sbjct: 391 EERIREREKKMREEEETMREQEEKMQ 416
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/218 (23%), Positives = 117/218 (53%), Gaps = 11/218 (5%)
Query: 348 QKMQEEEP-QKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
+KM+EE+ Q++ T++ + K E E EK+ + E+ RE E K Q+++E+
Sbjct: 534 EKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE-EEEMMREQEEKMQEQEEKMRE 592
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQE-LERQRRLEWERI 465
++ ++ EQE K Q + EK E++ ++ Q EE++ ++ E ++E ++ Q WE+
Sbjct: 593 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQE 652
Query: 466 RRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEV 525
+ +K REQEE ++ +++ + + E + G+ +++ R Q+ +++ Q +K +
Sbjct: 653 EKMREQEEKMREQEE--KMQGQEEKMREQEEKMQGQEEKM--REQEEKMRGQEEKMWGQE 708
Query: 526 LDKQCDLEIM----EIKQLQQELQEYQNKLIYLVPEKQ 559
E M E+++ ++ +++ + K+ +PE +
Sbjct: 709 EKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746
Score = 66.2 bits (160), Expect = 2e-10
Identities = 88/368 (23%), Positives = 161/368 (43%), Gaps = 100/368 (27%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+KM+E+E Q +E + K + M ++ R +++ RE E + +++K+ W+++
Sbjct: 479 EKMREQEDQM-----WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQE 533
Query: 408 QRELQEQEWKKQLELEKRL----EKQRELERQREEERRKDIERREAAKQELERQRRLEWE 463
++ +E KK E EK+ EK RE ER R ER K + E +E E + + + E
Sbjct: 534 EKMREE---KKTQEQEKKTWDQEEKMREEERMR--EREKKMREEEEMMREQEEKMQEQEE 588
Query: 464 RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT-E 522
++R QE +K EQEE K Q+ Q+ ++ +Q +K E
Sbjct: 589 KMREQE---EKMWEQEE--------------------KMQE-----QEEKMWEQEEKMWE 620
Query: 523 LEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLH 582
E DK + E M +Q ++++QE + K+
Sbjct: 621 QEEEDKMQEQEEMMWEQ-EEKMQEQEEKM------------------------------- 648
Query: 583 KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKR 642
E+EE +++EQ E++ + +M +++E E Q+
Sbjct: 649 ---WEQEE---KMREQ----EEKMREQEEKMQGQEEKMREQEEKMQGQE----------- 687
Query: 643 DKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQ 702
+K++E E K +K ++E K +E +W + +E+EE+ R Q+EK QE++
Sbjct: 688 EKMREQEEKMRGQEEKMWGQEE---KMWGQEEKMWGQEEMREKEER-IRDQKEKMQERLP 743
Query: 703 EEERKAEE 710
E E + E
Sbjct: 744 EHEERCSE 751
Score = 62.8 bits (151), Expect = 3e-09
Identities = 53/221 (23%), Positives = 117/221 (52%), Gaps = 31/221 (14%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+KM+EEE + ++++ E E E++ E+ Q + E+ ++E++ WE++
Sbjct: 567 KKMREEEEMMRE----QEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 622
Query: 408 QRE-LQEQE---WKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWE 463
+ + +QEQE W+++ +++++ EK E E + E+ K E+ E + + E+ R E E
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQE-E 681
Query: 464 RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTEL 523
+++ QE +K REQEE +R +K + G+ +++ G+ + + +++ ++ E
Sbjct: 682 KMQGQE---EKMREQEEKMRGQEEK---------MWGQEEKMWGQEEKMWGQEEMREKEE 729
Query: 524 EVLDKQCDLEIMEIKQLQQELQEYQNKLI--YLVPEKQLLN 562
+ D++ +++Q+ L E++ + L P K L N
Sbjct: 730 RIRDQK--------EKMQERLPEHEERCSEPCLPPSKVLCN 762
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 106 bits (264), Expect = 2e-22
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 70
Query: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 71 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 130
Query: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 131 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 187
Query: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 188 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 243
Query: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
+ + H D ++ ++ + L +Q E + KE
Sbjct: 244 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 278
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 12 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 67
Query: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
K VSPK L S P + A Y NV N+
Sbjct: 68 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 101
Score = 48.1 bits (113), Expect = 7e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 961 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 13 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 72
Query: 1020 KSGASNKKPE 1029
KSG P+
Sbjct: 73 KSGTLKSPPK 82
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 931
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 9 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 67
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 106 bits (264), Expect = 2e-22
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 139 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 198
Query: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 199 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 258
Query: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 259 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 315
Query: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 316 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 371
Query: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
+ + H D ++ ++ + L +Q E + KE
Sbjct: 372 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 406
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 140 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 195
Query: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
K VSPK L S P + A Y NV N+
Sbjct: 196 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 229
Score = 50.1 bits (118), Expect = 2e-05
Identities = 46/188 (24%), Positives = 82/188 (43%), Gaps = 20/188 (10%)
Query: 756 IIQVDEKTVGEP-GWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPK--------KALLP 806
+++ +KT+ +P G+L S + G C +E++ EK +L
Sbjct: 16 VLESPKKTISDPEGFLQASLKD--GVVLCRLLERLLPGTIEKTFDANDLYQGQNFNKVLS 73
Query: 807 PTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRT--VSPGSVSPI 864
V+L+ + S + A + ++ SF +L +S TRT + G +
Sbjct: 74 SLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLG------SQSLHTRTSKLFQGQYRSL 127
Query: 865 HGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSY 923
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +Y
Sbjct: 128 DMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNY 187
Query: 924 VKIIPGSE 931
V+ + SE
Sbjct: 188 VREVKASE 195
Score = 48.1 bits (113), Expect = 7e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 961 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 141 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 200
Query: 1020 KSGASNKKPE 1029
KSG P+
Sbjct: 201 KSGTLKSPPK 210
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 106 bits (264), Expect = 2e-22
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1163
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 189 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 248
Query: 1164 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1219
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 249 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 308
Query: 1220 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1278
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 309 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 365
Query: 1279 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1338
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 366 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 421
Query: 1339 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
+ + H D ++ ++ + L +Q E + KE
Sbjct: 422 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 456
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 190 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 245
Query: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 840
K VSPK L S P + A Y NV N+
Sbjct: 246 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 279
Score = 48.1 bits (113), Expect = 7e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 961 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1019
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 191 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 250
Query: 1020 KSGASNKKPE 1029
KSG P+
Sbjct: 251 KSGTLKSPPK 260
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 931
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 187 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 245
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,028,792
Number of Sequences: 37866
Number of extensions: 3271845
Number of successful extensions: 76394
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1228
Number of HSP's successfully gapped in prelim test: 1655
Number of HSP's that attempted gapping in prelim test: 18057
Number of HSP's gapped (non-prelim): 22038
length of query: 1670
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1554
effective length of database: 13,855,062
effective search space: 21530766348
effective search space used: 21530766348
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.