Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 194097347
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194097347 phosphoinositide-3-kinase, class 2 beta
polypeptide [Homo sapiens]
(1634 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 3345 0.0
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 1328 0.0
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 814 0.0
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 384 e-106
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 372 e-102
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 357 4e-98
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 348 3e-95
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 160 1e-38
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 130 8e-30
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 130 8e-30
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 113 2e-24
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 86 2e-16
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 83 2e-15
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 83 2e-15
gi|38570146 synaptotagmin VII [Homo sapiens] 82 3e-15
gi|6005997 double C2-like domains, beta [Homo sapiens] 81 7e-15
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 80 1e-14
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens] 76 2e-13
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens] 76 2e-13
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens] 76 2e-13
gi|47078261 double C2-like domains, alpha [Homo sapiens] 75 4e-13
gi|14249614 synaptotagmin-like 1 [Homo sapiens] 75 7e-13
gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapi... 74 2e-12
gi|209447073 synaptotagmin I [Homo sapiens] 72 3e-12
gi|5032139 synaptotagmin I [Homo sapiens] 72 3e-12
gi|209447070 synaptotagmin I [Homo sapiens] 72 3e-12
gi|45387945 family with sequence similarity 62 (C2 domain contai... 72 3e-12
gi|211059429 synaptotagmin II [Homo sapiens] 72 6e-12
gi|31543670 synaptotagmin II [Homo sapiens] 72 6e-12
gi|154354983 regulating synaptic membrane exocytosis 2 isoform a... 71 8e-12
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 3345 bits (8673), Expect = 0.0
Identities = 1634/1634 (100%), Positives = 1634/1634 (100%)
Query: 1 MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISW 60
MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISW
Sbjct: 1 MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISW 60
Query: 61 DEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPK 120
DEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPK
Sbjct: 61 DEPGVDFYSKPAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPK 120
Query: 121 GSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSS 180
GSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSS
Sbjct: 121 GSLSGDYLYIFDGSDGGVSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSS 180
Query: 181 SKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNL 240
SKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNL
Sbjct: 181 SKISQPSDINTFSLVEQLPGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNL 240
Query: 241 KSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNAT 300
KSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNAT
Sbjct: 241 KSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTMPPQVPPRTYASRYGNRKNAT 300
Query: 301 PGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGY 360
PGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGY
Sbjct: 301 PGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGY 360
Query: 361 VWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVD 420
VWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVD
Sbjct: 361 VWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVD 420
Query: 421 VGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQS 480
VGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQS
Sbjct: 421 VGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQS 480
Query: 481 PSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAIC 540
PSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAIC
Sbjct: 481 PSTLNYLVHLQERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAIC 540
Query: 541 NALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELY 600
NALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELY
Sbjct: 541 NALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELY 600
Query: 601 CNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSH 660
CNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSH
Sbjct: 601 CNTFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSH 660
Query: 661 GGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSS 720
GGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSS
Sbjct: 661 GGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSS 720
Query: 721 SEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVI 780
SEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVI
Sbjct: 721 SEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVI 780
Query: 781 LQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLW 840
LQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLW
Sbjct: 781 LQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLW 840
Query: 841 EKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVR 900
EKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVR
Sbjct: 841 EKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVR 900
Query: 901 RMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKD 960
RMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKD
Sbjct: 901 RMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKD 960
Query: 961 GLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILR 1020
GLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILR
Sbjct: 961 GLKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILR 1020
Query: 1021 TGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRV 1080
TGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRV
Sbjct: 1021 TGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRV 1080
Query: 1081 IFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRK 1140
IFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRK
Sbjct: 1081 IFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRK 1140
Query: 1141 IQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDN 1200
IQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDN
Sbjct: 1141 IQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDN 1200
Query: 1201 IMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDL 1260
IMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDL
Sbjct: 1201 IMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDL 1260
Query: 1261 CCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLI 1320
CCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLI
Sbjct: 1261 CCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLI 1320
Query: 1321 ESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFH 1380
ESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFH
Sbjct: 1321 ESSLGSVATKLNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFH 1380
Query: 1381 PNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGE 1440
PNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGE
Sbjct: 1381 PNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGE 1440
Query: 1441 AVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARP 1500
AVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARP
Sbjct: 1441 AVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARP 1500
Query: 1501 VGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKV 1560
VGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKV
Sbjct: 1501 VGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKV 1560
Query: 1561 ARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEK 1620
ARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEK
Sbjct: 1561 ARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEK 1620
Query: 1621 TGWFALGSRSHGTL 1634
TGWFALGSRSHGTL
Sbjct: 1621 TGWFALGSRSHGTL 1634
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 1328 bits (3437), Expect = 0.0
Identities = 688/1332 (51%), Positives = 931/1332 (69%), Gaps = 27/1332 (2%)
Query: 318 TVANGHELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLT-GYVWSAVTPSPEHLGDEV 376
++ G L + E ++EE+AAFC + L++ ++ GY+ S VT G+
Sbjct: 363 SLPTGSSLLQEVEVQNEEMAAFCRSITKLKTKFPYTNHRTNPGYLLSPVTAQRNICGENA 422
Query: 377 NLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQ 436
++KV++ + Q +TFTC+ SSTV+++I Q LC+ HDDL VDVG +VLK CG EE LQ
Sbjct: 423 SVKVSIDIEGFQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYVLKVCGQEEVLQ 482
Query: 437 NKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVK 496
N H LGSHE+IQ CRK+D +IRLQL+ + +LART DD++P LN ++ E+P K
Sbjct: 483 NNHCLGSHEHIQNCRKWDTEIRLQLLTFSAMCQNLARTAEDDETPVDLNKHLYQIEKPCK 542
Query: 497 QTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALN 556
+ ++R + L D+YHN+V+ L + D+V+++V+ IC+AL VET IT ++
Sbjct: 543 EAMTRHPVEELLDSYHNQVELALQIENQHRA-VDQVIKAVRKICSALDGVETLAITESVK 601
Query: 557 QLPPCPSRMQPKIQ--------KDPSVLAVR-----ENREKV-VEALTAAILDLVELYCN 602
+L + + K +D S + R EN +V + LTAAI DL+ L+ N
Sbjct: 602 KLKRAVNLPRSKTADVTSLFGGEDTSRSSTRGSLNPENPVQVSINQLTAAIYDLLRLHAN 661
Query: 603 TFNADFQTAVPGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGG 662
+ + A + V+EA L FT++A H I W ++YE +YL CSLSH G
Sbjct: 662 SGRSPTDCA----QSSKSVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNG 717
Query: 663 KELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSE 722
K+L P+Q+++ K F+LI WD+ I FP+Q+++LP E++L TL+ + GSS +
Sbjct: 718 KDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPD 777
Query: 723 ANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSAPNFHQPDSVILQ 782
+NKQR+ PEALG V+ PLF+F++ LTCG KLL LW ++ N + + ++LQ
Sbjct: 778 SNKQRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTSSHTNSVPGTVTKKGYVMERIVLQ 837
Query: 783 IDFPTSAFDIKFTSPPGDK-FSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWE 841
+DFP+ AFDI +T+P D+ ++ +L + + KL DI+ K+S L+ DK LWE
Sbjct: 838 VDFPSPAFDIIYTTPQVDRSIIQQHNLETLENDIKGKLLDILHKDSSLGLSKEDKAFLWE 897
Query: 842 KRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRR 901
KRYYC + LP +LASAP+W+W L Y LL QW + AL LL + F DQEVR
Sbjct: 898 KRYYCFKHPNCLPKILASAPNWKWVNLAKTYSLLHQWPALYPLIALELLDSKFADQEVRS 957
Query: 902 MAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDG 961
+AV WI ++SD EL D LPQ VQALKYE YL+S LV+FLL RA+ ++++ H +WLLKD
Sbjct: 958 LAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGNIQIAHNLYWLLKDA 1017
Query: 962 LKDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRT 1021
L D QFS RY+++L ALL GK LREE +Q LV L +A++VR+A+ SARQ +L+
Sbjct: 1018 LHDVQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLGGVAEKVRQASGSARQVVLQR 1077
Query: 1022 GLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVI 1081
+E V+ FF N CRLPL PSL+ K + + CS+F+SNAVPLK++ N DP+GE I V+
Sbjct: 1078 SMERVQSFFQKN-KCRLPLKPSLVAKELNIKSCSFFSSNAVPLKVTMVNADPMGEEINVM 1136
Query: 1082 FKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKI 1141
FK G+DLRQDML LQMI+IM KIW++EGLD+RMVIF+C STGR RGMVE++P ++TLRKI
Sbjct: 1137 FKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDRGMVELVPASDTLRKI 1196
Query: 1142 QVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNI 1201
QVE+GVTGSFKD+PLA+WL+K+NP E+EYEKA ENFIYSCAGCCVATYVLGICDRHNDNI
Sbjct: 1197 QVEYGVTGSFKDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNI 1256
Query: 1202 MLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLC 1261
ML++TGHMFHIDFG+FLGHAQMFG+ KRDRAPFV TSDMAYVINGG+KP+ RF FVDLC
Sbjct: 1257 MLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLC 1316
Query: 1262 CQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIE 1321
CQAYNLIRK T+LFLNLL LM+ G+PEL+ ++DLKYV DAL+PQ T+A AT +FTRLIE
Sbjct: 1317 CQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIE 1376
Query: 1322 SSLGSVATKLNFFIHNLAQMKFTG--SDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIF 1379
SSLGS+ATK NFFIHNLAQ++F+G S+D LSF+ +T++ + GRI +V + + K +
Sbjct: 1377 SSLGSIATKFNFFIHNLAQLRFSGLPSNDEPILSFSPKTYSFRQDGRIKEVSVFTYHKKY 1436
Query: 1380 HPNKGYIYVVKVMRENTHEATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRG 1439
+P+K YIYVV+++RE E +++ RTF+EFQELHNKL ++FP LP FP+R V+GR+
Sbjct: 1437 NPDKHYIYVVRILREGQIEPSFVFRTFDEFQELHNKLSIIFPLWKLPGFPNRMVLGRTHI 1496
Query: 1440 EAVAERRREELNGYIWHLIHAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWAR 1499
+ VA +R+ ELN Y+ L++A +VAECDLV TFFHPL RDEKA G A + G+++
Sbjct: 1497 KDVAAKRKIELNSYLQSLMNASTDVAECDLVCTFFHPLLRDEKAEGI--ARSADAGSFSP 1554
Query: 1500 PVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTK 1559
G++GG VKLSISY+N LFIMVMHI+ L + +DG DP+PYVK YLLPD KT+KRKTK
Sbjct: 1555 TPGQIGGAVKLSISYRNGTLFIMVMHIKDL-VTEDGADPNPYVKTYLLPDNHKTSKRKTK 1613
Query: 1560 VARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQE 1619
++RKT NPT+NEMLVY G K L+QRELQLSVLS + EN LG V + L++ +L++E
Sbjct: 1614 ISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRENFFLGGVTLPLKDFNLSKE 1673
Query: 1620 KTGWFALGSRSH 1631
W+ L + ++
Sbjct: 1674 TVKWYQLTAATY 1685
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 814 bits (2102), Expect = 0.0
Identities = 489/1310 (37%), Positives = 724/1310 (55%), Gaps = 105/1310 (8%)
Query: 324 ELFEVSEERDEEVAAFCHMLDILRSGSDIQDY-FLTGYVWSAVTPSPEHLGDEVNLKVTV 382
+L EV + + +A+FC+ + +R D F +G +WS T P L + + +
Sbjct: 233 QLVEVPQSSNTSLASFCNKVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHI 292
Query: 383 LCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGLEEFLQNKHALG 442
D + L F + V LI + L + +D + D +L CG EEFLQN H LG
Sbjct: 293 FIDNSTQPLHFMPCANYLVKDLIAEILHFCTND--QLLPKDHILSVCGSEEFLQNDHCLG 350
Query: 443 SHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHLQERPVKQTISRQ 502
SH+ Q + I+L L + + L+R +D S LN L+ +SRQ
Sbjct: 351 SHKMFQKDKSV---IQLHLQKSREAPGKLSRKHEEDHSQFYLNQLLEFMHI---WKVSRQ 404
Query: 503 ALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCP 562
L L Y + L + +++ VK IC+ L VET +IT A+N+L
Sbjct: 405 CLLTLIRKYDFHLKYLLKTQEN----VYNIIEEVKKICSVLGCVETKQITDAVNELSLIL 460
Query: 563 SRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTA-VPGSRKHDLV 621
R + S + + EKV L+ +I L+ +YCN+F ADFQ VP +
Sbjct: 461 QRKGENFYQS-SETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNP 519
Query: 622 QEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLF 681
H L+FTVYA H IP
Sbjct: 520 GLPSH----LSFTVYAAHNIPE-------------------------------------- 537
Query: 682 HLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLF 741
W +I FP+++ LPRE++L L+ + +++ AN L W PLF
Sbjct: 538 ---TWVHRINFPLEIKSLPRESMLTVKLFGIAC----ATNNAN-------LLAWTCLPLF 583
Query: 742 NFRQVLTCGRKLLGLWPATQENPSARWSAP---NFHQPDSVILQIDFPTSAFDIKFTSPP 798
++ G L + Q P P + QP V LQIDFP + ++ + P
Sbjct: 584 P-KEKSILGSMLFSM--TLQSEPPVEMITPGVWDVSQPSPVTLQIDFPATGWE--YMKP- 637
Query: 799 GDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLA 858
D R +E + + + QK++ L++ K+ LW R+YC++E SLPLVL
Sbjct: 638 -DSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLG 696
Query: 859 SAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDY 918
SAP W+ + +++ +L++WT +ALGLL ++FPDQE+R++AVQ + +L + ELL+Y
Sbjct: 697 SAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDELLEY 756
Query: 919 LPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAAL 978
LPQLVQA+K+E L+SPLV+ LL R++ ++V H +WLLK+ ++ F YQ LLAAL
Sbjct: 757 LPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAAL 816
Query: 979 LCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRL 1038
C GK L +EF+++ L+ L + ++V+ A+ RQ +L+ + +++FF +C L
Sbjct: 817 QFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHL 876
Query: 1039 PLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMI 1098
PL+P+L +KGI CSYF SNA+PLK++F N +P+G+NI +IFK GDDLRQDML LQ+I
Sbjct: 877 PLNPALCIKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLI 936
Query: 1099 RIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLAD 1158
++M IW+QEGLDM+M+I+RC STG+ +G+V+M+P+A TL KI G+ G K+ +
Sbjct: 937 QVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKK 996
Query: 1159 WLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFL 1218
W +HN + +YEKA+ NF YSCAG CV T++LG+CDRHNDNIML +GHMFHIDFG+FL
Sbjct: 997 WFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFL 1056
Query: 1219 GHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNL 1278
GHAQ FG IKRDRAPF+FTS+M Y I G K F DFV+LCC+AYN+IRKH+ L LNL
Sbjct: 1057 GHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNPQHFQDFVELCCRAYNIIRKHSQLLLNL 1116
Query: 1279 LGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNFFIHNL 1338
L +ML G+PELS ++DLKYVY+ LRPQDT+ AT++FT+ I+ SL KLN IH L
Sbjct: 1117 LEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTL 1176
Query: 1339 AQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHE 1398
AQM + +F + L ++ I + F +Y+++V N +E
Sbjct: 1177 AQMSAISPAKSTSQTFPQESCLLSTTRSIERATILG----FSKKSSNLYLIQVTHSN-NE 1231
Query: 1399 ATYIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLI 1458
+ +++FE+F +LH++L+ F S LP FP + + + + RR +LN Y+ ++
Sbjct: 1232 TSLTEKSFEQFSKLHSQLQKQFASLTLPEFPHWWHLPFTNSD---HRRFRDLNHYMEQIL 1288
Query: 1459 HAPPEVAECDLVYTFFHPLPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNK 1518
+ EV D V +FF + +SP +P +V+L ISY++ K
Sbjct: 1289 NVSHEVTNSDCVLSFFLSEAVQQTVEESSPVYLGEKFPDKKP------KVQLVISYEDVK 1342
Query: 1519 LFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGI 1578
L I+V H++ + L DG+ P +V+ YLLP P + +RKTK K +PTYNE++VYD +
Sbjct: 1343 LTILVKHMKNIH-LPDGSAPSAHVEFYLLPYPSEVRRRKTKSVPKCTDPTYNEIVVYDEV 1401
Query: 1579 PKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGWFALGS 1628
+LQ L L V S + V +G +NIRL + L +EK W+ LG+
Sbjct: 1402 T--ELQGHVLMLIVKS-----KTVFVGAINIRLCSVPLDKEK--WYPLGN 1442
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 384 bits (985), Expect = e-106
Identities = 256/749 (34%), Positives = 382/749 (51%), Gaps = 67/749 (8%)
Query: 640 RIPIIWAT-------SYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICF 692
RI I+ AT + Y+ + HGG+ LC + T+R S W++ + +
Sbjct: 335 RIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPR-----WNEWLNY 389
Query: 693 PVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRK 752
+ + LPR LC ++ ++ + K+ P L W LF++ L G+
Sbjct: 390 DIYIPDLPRAARLCLSICSV------KGRKGAKEEHCP--LAWGNINLFDYTDTLVSGKM 441
Query: 753 LLGLWPATQE-----NP-SARWSAPNFHQPDSVILQIDFPTSAFDIKFTS----PPGDKF 802
L LWP NP S PN P L+++F + +KF +
Sbjct: 442 ALNLWPVPHGLEDLLNPIGVTGSNPNKETP---CLELEFDWFSSVVKFPDMSVIEEHANW 498
Query: 803 SPRYEFG----------------SLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYC 846
S E G LRE D+ +LK I ++ L +T+ +K LW R+YC
Sbjct: 499 SVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYC 558
Query: 847 HSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQW 906
+ LP +L S + +Y L+K W + + A+ LL +PD VR AV+
Sbjct: 559 VTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRC 618
Query: 907 IGS-LSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDS 965
+ L+D +L YL QLVQ LKYE YLD+ LVRFLLK+A+++ R+ H+FFW LK + +
Sbjct: 619 LEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNK 678
Query: 966 QFSIRYQYLLAALLCCCGKGLREEFNRQC----WLVNALAKLAQQVREAAPSARQGILRT 1021
S R+ LL + CG L+ NRQ L+N L Q+ ++ + L
Sbjct: 679 TVSQRFGLLLESYCRACGMYLK-HLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVE 737
Query: 1022 GLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGE----N 1077
+ AL G PL+P+ + + +C +S PL L+++N D + E N
Sbjct: 738 QMRRPDFMDALQGFLS-PLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQN 796
Query: 1078 IRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAET 1137
+IFK GDDLRQDMLTLQ+IRIM IW +GLD+RM+ + C S G G++E++ N+ T
Sbjct: 797 NEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHT 856
Query: 1138 LRKIQVEHGVTGS--FKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICD 1195
+ +IQ + G+ G+ F L WL+ N GE Y+ A++ F SCAG CVAT++LGI D
Sbjct: 857 IMQIQCKGGLKGALQFNSHTLHQWLKDKNKGE-IYDAAIDLFTRSCAGYCVATFILGIGD 915
Query: 1196 RHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSR-- 1253
RHN NIM+K G +FHIDFG FL H + KR+R PFV T D VI+ G + ++
Sbjct: 916 RHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTR 975
Query: 1254 -FHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANA 1312
F F ++C +AY IR+H +LF+NL +ML G+PEL +D+ Y+ L TE A
Sbjct: 976 EFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEA 1035
Query: 1313 TTYFTR-LIESSLGSVATKLNFFIHNLAQ 1340
YF + + ++ G TK+++ H + Q
Sbjct: 1036 LEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064
Score = 34.3 bits (77), Expect = 1.0
Identities = 16/50 (32%), Positives = 27/50 (54%)
Query: 422 GDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDL 471
G ++LK CG +E+ K+ L ++YI+ C L LM ++ + S L
Sbjct: 248 GKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQL 297
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 372 bits (956), Expect = e-102
Identities = 246/738 (33%), Positives = 381/738 (51%), Gaps = 48/738 (6%)
Query: 641 IPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLP 700
IP++ + ++ ++ HG + LC +R K ++W+ + F +++ LP
Sbjct: 370 IPVLPRNTDLTVFVEANIQHGQQVLC-----QRRTSPKPFTEEVLWNVWLEFSIKIKDLP 424
Query: 701 RETLLCATLYALPIPPPGSSSEA----NKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGL 756
+ LL +Y P S + A ++ + + L +V L + R +L G +L +
Sbjct: 425 KGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHM 484
Query: 757 WPATQE-------NPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTS------PPGDKFS 803
W + + N SA N + +S+ + I I P GD+
Sbjct: 485 WQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVR 544
Query: 804 PRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYCHSEVSSLPLVLASAPSW 863
+ + +++L+ I+ + L LT DK+ LW RY + P + +S
Sbjct: 545 -----AEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWG 599
Query: 864 EWACLPDIYVLLKQWTHMNHQDALG------LLHATFPDQEVRRMAVQWIGSLSDAELLD 917
+ + Y LL + + Q AL LL F D+ VR +AVQ + SL D ++L
Sbjct: 600 QQEIVAKTYQLLAR-REVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLH 658
Query: 918 YLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQ-FSIRYQYLLA 976
YL QLVQA+K+E Y DS L RFLLKR + + R+ H+ FW L+ + S+ + R+ +L
Sbjct: 659 YLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILE 718
Query: 977 ALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFA----- 1031
A L CG + +F +Q ++ L K+ ++ + + + + + ++KQ
Sbjct: 719 AYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLS-AEKYDVSSQVISQLKQKLENLQNS 777
Query: 1032 -LNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLG---ENIRVIFKCGDD 1087
L S R+P P L + C S PL L F+ DP E I +IFK GDD
Sbjct: 778 QLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDD 837
Query: 1088 LRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEH-G 1146
LRQDML LQ++RIM IW E LD+ ++ + C STG GM+E++ +A T+ KIQ G
Sbjct: 838 LRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVG 897
Query: 1147 VTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTT 1206
TG+FKD L WL++ +P E++++ AVE F+YSCAG CVAT+VLGI DRHNDNIM+ T
Sbjct: 898 NTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITET 957
Query: 1207 GHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVI-NGGDKPSSRFHDFVDLCCQAY 1265
G++FHIDFG LG+ + F I ++R PFV T D +V+ G K S F F D+C +AY
Sbjct: 958 GNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAY 1017
Query: 1266 NLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLG 1325
+R HT+L + L +ML G+P+L+ ED++Y+ DAL E +A YF IE
Sbjct: 1018 LALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRD 1077
Query: 1326 SVAT-KLNFFIHNLAQMK 1342
T + N+F+H + +K
Sbjct: 1078 KGWTVQFNWFLHLVLGIK 1095
Score = 34.3 bits (77), Expect = 1.0
Identities = 38/187 (20%), Positives = 77/187 (41%), Gaps = 19/187 (10%)
Query: 292 RYGNRKNATPGKNRRISAAPVGS------RPHTVANGHELFEVSEERDEEVAAFCHMLDI 345
RY + +PG+ + P R T G+++ +VS D+E+ L
Sbjct: 123 RYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVT 182
Query: 346 LR----SGSDIQDYFLTGYVWSAVTPSPEHLGDEV-NLKVTVLCDRLQEALTFTCNCSST 400
R + D + Y + + W P PE+L ++ N + ++ R + T + T
Sbjct: 183 PRMAEVASRDPKLYAM--HPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDT 240
Query: 401 VDLLIYQTLCYTHDDLRNVDVG------DFVLKPCGLEEFLQNKHALGSHEYIQYCRKFD 454
++ +D+ DFVL+ CG +E+L + + + +++++C K
Sbjct: 241 PGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNG 300
Query: 455 IDIRLQL 461
+I + L
Sbjct: 301 EEIHVVL 307
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 357 bits (917), Expect = 4e-98
Identities = 288/991 (29%), Positives = 466/991 (47%), Gaps = 112/991 (11%)
Query: 398 SSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGL-EEFLQNKHALGSHEYIQYCRKFDID 456
+S + LLI + L + D L + +V DF K C EE + LG ++QY ++
Sbjct: 114 NSQISLLIGKGL-HEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLE 172
Query: 457 IRLQLMEQKVVRSD---LARTVNDDQSPSTLNYLVHLQERPV---------KQTISRQAL 504
Q +R L V + S + + V ++ P+ K T+ RQ L
Sbjct: 173 PSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPL 232
Query: 505 SLLFDTYHNEVDA---FLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALN----- 556
+ Y +V+ +L G +PL + IC+ L + TP +T +
Sbjct: 233 VEQPEDYTLQVNGRHEYLY--GSYPLC------QFQYICSCLHSGLTPHLTMVHSSSILA 284
Query: 557 ----QLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAV 612
Q P P +P+ K P + A + + + ++L++
Sbjct: 285 MRDEQSNPAPQVQKPRA-KPPPIPAKKPSSVSLWSLEQPFRIELIQ-------------- 329
Query: 613 PGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTR 672
GS+ V A R+ ++ + L HG + LC + +
Sbjct: 330 -GSK------------------VNADERMKLV---------VQAGLFHGNEMLCKTVSSS 361
Query: 673 RAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEA 732
VW Q++ F + + LPR LC LYA+ + S K ++
Sbjct: 362 EVSVCSEP----VWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCP 417
Query: 733 LGWVTTPLFNFRQVLTCGRKLLGLWPATQE------NPSARWSAPNFHQPDSVILQIDFP 786
+ W LF+++ L G + L +WP+ + NP+ + N + + L I P
Sbjct: 418 IAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRS-NPNTDSAAALLICLP 476
Query: 787 TSAFDIKFTSPPGDKF---SPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKR 843
A + P +K E + EE+Q +L++I+++ L + +K +W+ R
Sbjct: 477 EVAPHPVYY-PALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLR 535
Query: 844 YYCHSEVSSLPLVLASAPSW-EWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRM 902
+ L W + + + LL W + AL LL +FPD V
Sbjct: 536 HEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSF 595
Query: 903 AVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGL 962
A++ + L+D EL YL QLVQ LKYE YLD L +FLL RA+++ ++ H+ FW L+ +
Sbjct: 596 AIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEM 655
Query: 963 KDSQFSIRYQYLLAALLCCCG-----KGLREEFNRQCWL--VNALAKLAQQVREAAPSAR 1015
++R+ +L A C G K L ++ L +N KL+ Q + P +
Sbjct: 656 HVPSVALRFGLILEAY--CRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQ-KTPKPQTK 712
Query: 1016 QGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDP-L 1074
+ ++ + + AL+ + PL PS L+ + C++ +S PL + + N +
Sbjct: 713 E-LMHLCMRQEAYLEALS-HLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGS 770
Query: 1075 GENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPN 1134
G ++ +IFK GDDLRQDMLTLQMI++M +W QEGLD+RM + C TG G++E++
Sbjct: 771 GGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLR 830
Query: 1135 AETLRKIQVEHG---VTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVL 1191
++T+ IQ+ T +F L +WL+ NPGE ++A+E F SCAG CVATYVL
Sbjct: 831 SDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGE-ALDRAIEEFTLSCAGYCVATYVL 889
Query: 1192 GICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVI-NGGDKP 1250
GI DRH+DNIM++ +G +FHIDFG FLG+ + I R+R PF+ T D +VI G
Sbjct: 890 GIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNN 949
Query: 1251 SSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEA 1310
S +F F C +AY ++R+H LFL+L LM + G+PELS +D++Y+ D+L TE
Sbjct: 950 SEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEE 1009
Query: 1311 NATTYF-TRLIESSLGSVATKLNFFIHNLAQ 1340
A +F + E+ S TK+N+ HN+++
Sbjct: 1010 EALKHFRVKFNEALRESWKTKVNWLAHNVSK 1040
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 348 bits (892), Expect = 3e-95
Identities = 235/725 (32%), Positives = 376/725 (51%), Gaps = 51/725 (7%)
Query: 653 YLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYAL 712
++ L HG + LC + + + S H +W++ + F + + LPR LC +YA+
Sbjct: 352 HVRAGLFHGTELLCKTIVS--SEVSGKNDH--IWNEPLEFDINICDLPRMARLCFAVYAV 407
Query: 713 ----------PIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQE 762
P K +V + WV T +F+F+ L G +L W + +
Sbjct: 408 LDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPD 467
Query: 763 ------NPSARWSAPNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRY------EFGS 810
NP N + ++ L + FP + + PP DK + + +
Sbjct: 468 ELEEMLNPMGTVQT-NPYTENATALHVKFPENKKQ-PYYYPPFDKIIEKAAEIASSDSAN 525
Query: 811 LREEDQRK----LKDIMQKESLYWLTDADKKRLWEKRYYCHSEV-SSLPLVLASAPSWEW 865
+ +K LK+I+ ++ L L + + +W R C SLP +L S +W
Sbjct: 526 VSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSI---KW 582
Query: 866 ACLPDI---YVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQL 922
L D+ LL+ W + ++AL LL +PDQ VR AV + +SD EL YL QL
Sbjct: 583 NKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQL 642
Query: 923 VQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLCCC 982
VQ LKYE +LD L RFLL+RA+ + R+ + FW L+ + S+++ +L A C
Sbjct: 643 VQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAY-CRG 701
Query: 983 GKGLREEFNRQCWLVNALAKLAQQVREAAPSARQG----ILRTGLEEVKQFFALNGSCRL 1038
G + ++Q +N L L ++ A + + T L++ AL+ +
Sbjct: 702 SVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALS-DLQS 760
Query: 1039 PLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMI 1098
PL+P +++ + C Y +S PL L + N +++ VIFK GDDLRQDMLTLQM+
Sbjct: 761 PLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQML 820
Query: 1099 RIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHG---VTGSFKDRP 1155
R+M +W + GLD+RM+ + C +TG G++E++ +ET+ IQ+ +F
Sbjct: 821 RLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDA 880
Query: 1156 LADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFG 1215
L +WL+++N G+D ++A+E F SCAG CVA+YVLGI DRH+DNIM+K TG +FHIDFG
Sbjct: 881 LLNWLKEYNSGDD-LDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFG 939
Query: 1216 RFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSS-RFHDFVDLCCQAYNLIRKHTHL 1274
LG+ + IKR+R PF+ T D +VI G ++ +F F C AY ++R+H +L
Sbjct: 940 HILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNL 999
Query: 1275 FLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSL-GSVATKLNF 1333
F+ L LML+ G+PEL+ ++D++Y+ D+L +E A F + + +L S TK+N+
Sbjct: 1000 FITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNW 1059
Query: 1334 FIHNL 1338
H +
Sbjct: 1060 MAHTV 1064
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
Length = 887
Score = 160 bits (404), Expect = 1e-38
Identities = 119/427 (27%), Positives = 197/427 (46%), Gaps = 32/427 (7%)
Query: 932 LDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIR-------YQYLLAALLCCCGK 984
L+ L FL+ RA + + +Y +W + +D R Y ++ K
Sbjct: 471 LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLK 530
Query: 985 G------LREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGL---EEVKQFFALNGS 1035
G +R Q V+ L L + V+ + + ++ R + K +
Sbjct: 531 GDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVEL 590
Query: 1036 CRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTL 1095
LPL P + ++GI+P + F S +P +L F+ D G VIFK GDDLRQD L L
Sbjct: 591 IPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED--GGKYPVIFKHGDDLRQDQLIL 648
Query: 1096 QMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRP 1155
Q+I +M K+ +E LD+++ ++ +T G ++ I + + E + F+
Sbjct: 649 QIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRK-- 706
Query: 1156 LADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFG 1215
+ N + ++ ++ SCAG CV TY+LG+ DRH DN++L TG +FHIDFG
Sbjct: 707 ---YAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFG 763
Query: 1216 RFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLF 1275
LG + K P +M V G S ++ +F C A+ +R++++L
Sbjct: 764 YILGR-----DPKPLPPPMKLNKEM--VEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLI 816
Query: 1276 LNLLGLMLSCGIPELSDLED--LKYVYDALRPQDTEANATTYFTRLIESSLGSVATKLNF 1333
LNL LM+ IP+++ D +K V D R ++ A Y LI+ S+ ++ +
Sbjct: 817 LNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVE 876
Query: 1334 FIHNLAQ 1340
IH AQ
Sbjct: 877 QIHKFAQ 883
Score = 55.5 bits (132), Expect = 4e-07
Identities = 39/107 (36%), Positives = 58/107 (54%), Gaps = 8/107 (7%)
Query: 831 LTDADKKRLWEKRYYCHSEVSSLPLVLASAPSWEWACLPD----IYVLLKQWTHMNHQDA 886
LT ++ +W+ RYY ++ +L L +W+ LP LL +W M+ +D+
Sbjct: 308 LTYEEQDLVWKFRYYLTNQEKALTKFLKCV-NWD---LPQEAKQALELLGKWKPMDVEDS 363
Query: 887 LGLLHATFPDQEVRRMAVQWIGSLSDAELLDYLPQLVQALKYECYLD 933
L LL + + + VRR AV + D +LL YL QLVQALKYE + D
Sbjct: 364 LELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDD 410
Score = 35.0 bits (79), Expect = 0.60
Identities = 31/128 (24%), Positives = 53/128 (41%), Gaps = 16/128 (12%)
Query: 644 IWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLPRET 703
++ + D Y++C + GK L P++T FS W++ + PV+ LPR
Sbjct: 49 LYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRW----NWNEWLKLPVKYPDLPRNA 104
Query: 704 LLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQEN 763
+ T++ + PG + VP +G T LF + G L +WP + +
Sbjct: 105 QVALTIW--DVYGPG--------KAVP--VGGTTVSLFGKYGMFRQGMHDLKVWPNVEAD 152
Query: 764 PSARWSAP 771
S P
Sbjct: 153 GSEPTKTP 160
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 [Homo
sapiens]
Length = 854
Score = 130 bits (328), Expect = 8e-30
Identities = 128/516 (24%), Positives = 221/516 (42%), Gaps = 61/516 (11%)
Query: 850 VSSLPLVLASAPSWEW--ACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVR-RMAVQW 906
VS +P + +W A P++ +L W + L + +P + + V+
Sbjct: 335 VSDVPEAIKFLVTWHTIDADAPELSHVLC-WAPTDPPTGLSYFSSMYPPHPLTAQYGVKV 393
Query: 907 IGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGL---- 962
+ S +L Y+PQ+VQAL+Y+ + ++L A + H F W +K +
Sbjct: 394 LRSFPPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDE 451
Query: 963 ----KDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPS-ARQG 1017
KD L+ + ++ + R+ N + ++ ++ R+
Sbjct: 452 EGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKK 511
Query: 1018 ILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLG-- 1075
+ L EVK + C LP +P +V I + + S A L+ V G
Sbjct: 512 ACLSALSEVK----VQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVS 567
Query: 1076 ----ENIR-----------------------VIFKCGDDLRQDMLTLQMIRIMSKIWVQE 1108
E +R IFK GDD RQDML LQ+I + I+
Sbjct: 568 ELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLV 627
Query: 1109 GLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGED 1168
GLD+ + +R +T G G++E IP+ + ++ G D + D+ + E
Sbjct: 628 GLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL-------GRQTDFGMYDYFTRQYGDES 680
Query: 1169 --EYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGN 1226
+++A NFI S A + ++L I DRHN NIML GH+ HIDFG F+ + GN
Sbjct: 681 TLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFG-FMFESSPGGN 739
Query: 1227 IKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCG 1286
+ + P + +D +I GG ++ F F+++C + Y +R + ++L+ LML G
Sbjct: 740 LGWE--PDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTG 797
Query: 1287 IPELSDLEDLKYVYDALRPQDTEANATTYFTRLIES 1322
+P + +K + P TE A + ++I+S
Sbjct: 798 LPCFRG-QTIKLLKHRFSPNMTEREAANFIMKVIQS 832
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 130 bits (328), Expect = 8e-30
Identities = 128/516 (24%), Positives = 221/516 (42%), Gaps = 61/516 (11%)
Query: 850 VSSLPLVLASAPSWEW--ACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVR-RMAVQW 906
VS +P + +W A P++ +L W + L + +P + + V+
Sbjct: 1525 VSDVPEAIKFLVTWHTIDADAPELSHVLC-WAPTDPPTGLSYFSSMYPPHPLTAQYGVKV 1583
Query: 907 IGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGL---- 962
+ S +L Y+PQ+VQAL+Y+ + ++L A + H F W +K +
Sbjct: 1584 LRSFPPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDE 1641
Query: 963 ----KDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPS-ARQG 1017
KD L+ + ++ + R+ N + ++ ++ R+
Sbjct: 1642 EGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKK 1701
Query: 1018 ILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLG-- 1075
+ L EVK + C LP +P +V I + + S A L+ V G
Sbjct: 1702 ACLSALSEVK----VQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVS 1757
Query: 1076 ----ENIR-----------------------VIFKCGDDLRQDMLTLQMIRIMSKIWVQE 1108
E +R IFK GDD RQDML LQ+I + I+
Sbjct: 1758 ELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLV 1817
Query: 1109 GLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGED 1168
GLD+ + +R +T G G++E IP+ + ++ G D + D+ + E
Sbjct: 1818 GLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL-------GRQTDFGMYDYFTRQYGDES 1870
Query: 1169 --EYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGN 1226
+++A NFI S A + ++L I DRHN NIML GH+ HIDFG F+ + GN
Sbjct: 1871 TLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFG-FMFESSPGGN 1929
Query: 1227 IKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCG 1286
+ + P + +D +I GG ++ F F+++C + Y +R + ++L+ LML G
Sbjct: 1930 LGWE--PDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTG 1987
Query: 1287 IPELSDLEDLKYVYDALRPQDTEANATTYFTRLIES 1322
+P + +K + P TE A + ++I+S
Sbjct: 1988 LPCFRG-QTIKLLKHRFSPNMTEREAANFIMKVIQS 2022
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 113 bits (282), Expect = 2e-24
Identities = 73/257 (28%), Positives = 128/257 (49%), Gaps = 14/257 (5%)
Query: 1078 IRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAET 1137
+ VI KCGDDLRQ++L Q+++ + IW QE + + + ++ GM+E + NA +
Sbjct: 571 LSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 630
Query: 1138 LRKIQVEHGVTGSFKDRPLADW-LQKHNPGEDE-YEKAVENFIYSCAGCCVATYVLGICD 1195
+ +++ + ++ L D+ LQ+H E + A NF+ SCAG C+ Y+L + D
Sbjct: 631 IHQVKKQSQLS-------LLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 683
Query: 1196 RHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFH 1255
RHN NI+L GH+ HIDFG L + N+ + + F T++ V+ G D F+
Sbjct: 684 RHNGNILLDAEGHIIHIDFGFILSSSPR--NLGFETSAFKLTTEFVDVMGGLD--GDMFN 739
Query: 1256 DFVDLCCQAYNLIRKHTHLFLNLLGLM-LSCGIPELSDLEDLKYVYDALRPQDTEANATT 1314
+ L Q RKH + ++ +M +P ++ + + TE
Sbjct: 740 YYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQL 799
Query: 1315 YFTRLIESSLGSVATKL 1331
++++ S+ S+ TKL
Sbjct: 800 LVEQMVDGSMRSITTKL 816
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase type
3 alpha [Homo sapiens]
Length = 286
Score = 86.3 bits (212), Expect = 2e-16
Identities = 52/137 (37%), Positives = 75/137 (54%), Gaps = 9/137 (6%)
Query: 1081 IFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRK 1140
IFK GDD RQDML LQ+I + I+ GLD+ + +R +T G G++E IP+ + +
Sbjct: 54 IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQ 113
Query: 1141 IQVEHGVTGSFKDRPLADWLQKHNPGED--EYEKAVENFIYSCAGCCVATYVLGICDRHN 1198
+ G D + D+ + E +++A NFI S A + ++L I DRHN
Sbjct: 114 L-------GRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHN 166
Query: 1199 DNIMLKTTGHMFHIDFG 1215
NIML GH+ HIDFG
Sbjct: 167 GNIMLDKKGHIIHIDFG 183
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 82.8 bits (203), Expect = 2e-15
Identities = 44/117 (37%), Positives = 66/117 (56%), Gaps = 2/117 (1%)
Query: 1506 GEVKLSISYK--NNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G ++ S+ Y N+ L ++ +GL+ + DPYVK++LLP K+ K +TK R
Sbjct: 394 GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRN 453
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEK 1620
T NP +NE LVY GI D+Q++ L++SV E F N +GE L++L Q K
Sbjct: 454 TRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRK 510
Score = 57.4 bits (137), Expect = 1e-07
Identities = 34/89 (38%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 1506 GEVKLSISYKNNKLFIMVMHIRGLQLL-QDGND-PDPYVKIYLLPDPQKTTKRKTKVARK 1563
G++ +S+ Y + ++V IR + L D N DP+VK++L PD K K KT++ +K
Sbjct: 552 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKK 611
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSV 1592
T NP +NE YD I DL ++ L +SV
Sbjct: 612 TLNPEFNEEFFYD-IKHSDLAKKSLDISV 639
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 82.8 bits (203), Expect = 2e-15
Identities = 44/117 (37%), Positives = 66/117 (56%), Gaps = 2/117 (1%)
Query: 1506 GEVKLSISYK--NNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G ++ S+ Y N+ L ++ +GL+ + DPYVK++LLP K+ K +TK R
Sbjct: 390 GALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRN 449
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEK 1620
T NP +NE LVY GI D+Q++ L++SV E F N +GE L++L Q K
Sbjct: 450 TRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRK 506
Score = 57.4 bits (137), Expect = 1e-07
Identities = 34/89 (38%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 1506 GEVKLSISYKNNKLFIMVMHIRGLQLL-QDGND-PDPYVKIYLLPDPQKTTKRKTKVARK 1563
G++ +S+ Y + ++V IR + L D N DP+VK++L PD K K KT++ +K
Sbjct: 548 GKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKK 607
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSV 1592
T NP +NE YD I DL ++ L +SV
Sbjct: 608 TLNPEFNEEFFYD-IKHSDLAKKSLDISV 635
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 82.4 bits (202), Expect = 3e-15
Identities = 53/136 (38%), Positives = 73/136 (53%), Gaps = 9/136 (6%)
Query: 1506 GEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G ++ S+ Y + + L + +M + L DP+VKIYLLPD K K +TKV RK
Sbjct: 137 GRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLLPD--KKHKLETKVKRK 194
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGW 1623
NP +NE +++G P + QR L L VL F N +GEV+I L ++DL Q +T W
Sbjct: 195 NLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFW 254
Query: 1624 FAL-----GSRSHGTL 1634
L GS S G L
Sbjct: 255 KDLKPCSDGSGSRGEL 270
Score = 60.8 bits (146), Expect = 1e-08
Identities = 33/117 (28%), Positives = 64/117 (54%), Gaps = 9/117 (7%)
Query: 1493 SDGTWARPVGKVGGEVKLSISYKN--NKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDP 1550
SDG+ +R GE+ LS+ Y N + + ++ R L+ + G DPYVK++L+
Sbjct: 261 SDGSGSR------GELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKD 314
Query: 1551 QKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEV 1607
++ K+KT ++ NP +NE +D IP L++ + ++V+ + N ++G++
Sbjct: 315 KRVEKKKTVTMKRNLNPIFNESFAFD-IPTEKLRETTIIITVMDKDKLSRNDVIGKI 370
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 81.3 bits (199), Expect = 7e-15
Identities = 44/118 (37%), Positives = 64/118 (54%), Gaps = 2/118 (1%)
Query: 1506 GEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G + S+ Y +NN L + +GL+ + DPYVK++LLP K K +TK R
Sbjct: 128 GTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRN 187
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKT 1621
T NPT+NE L Y GI D+ ++ L++SV E F N +GE + L++L KT
Sbjct: 188 TLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKT 245
Score = 62.8 bits (151), Expect = 3e-09
Identities = 36/89 (40%), Positives = 52/89 (58%), Gaps = 3/89 (3%)
Query: 1506 GEVKLSISYKNNKLFIMVMHIRGLQLL-QDGND-PDPYVKIYLLPDPQKTTKRKTKVARK 1563
G + +S+ Y + K ++V +R L D N DPYVK YL PD K +K KT V +K
Sbjct: 268 GRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKK 327
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSV 1592
T NP +NE Y+ I GDL ++ L+++V
Sbjct: 328 TLNPEFNEEFCYE-IKHGDLAKKSLEVTV 355
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 80.5 bits (197), Expect = 1e-14
Identities = 53/138 (38%), Positives = 79/138 (57%), Gaps = 9/138 (6%)
Query: 1494 DGTWARPVGKVGGEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDP-DPYVKIYLLPDP 1550
D P G +G +VKL++ Y + KL +V R L+ Q+G DP DPYV + LLPD
Sbjct: 962 DSPLEAPAGPLG-QVKLTLWYYSEERKLVSIVHGCRSLR--QNGRDPPDPYVSLLLLPDK 1018
Query: 1551 QKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFW--ENVLLGEVN 1608
+ TKR+T ++T +P +NE ++ +P + Q+R+L +SV S F E LLG+V
Sbjct: 1019 NRGTKRRTSQKKRTLSPEFNERFEWE-LPLDEAQRRKLDVSVKSNSSFMSRERELLGKVQ 1077
Query: 1609 IRLRELDLAQEKTGWFAL 1626
+ L E DL+Q W+ L
Sbjct: 1078 LDLAETDLSQGVARWYDL 1095
>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 76.3 bits (186), Expect = 2e-13
Identities = 53/127 (41%), Positives = 63/127 (49%), Gaps = 5/127 (3%)
Query: 1503 KVGGEVKLSISY--KNNKLFIMVMHIRGLQLLQDGND-PDPYVKIYLLPDPQKTTKRKTK 1559
KV GE+ L ISY K L+I V + R L + + D YVK YLLPD + KRKTK
Sbjct: 405 KVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK 464
Query: 1560 VARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQE 1619
+ R NP +NE L Y I L+ R LQLSV F N LGEV I +
Sbjct: 465 I-RTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENP 522
Query: 1620 KTGWFAL 1626
WF L
Sbjct: 523 TDEWFVL 529
Score = 66.6 bits (161), Expect = 2e-10
Identities = 34/104 (32%), Positives = 55/104 (52%)
Query: 1506 GEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTC 1565
G+ K S L + + + L ++ G D +VK YLLPD K TK KT V +K+
Sbjct: 576 GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSV 635
Query: 1566 NPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNI 1609
NP +N ++ GI D++ L+L++ ++ F N+ LG V +
Sbjct: 636 NPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 679
>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
Length = 752
Score = 76.3 bits (186), Expect = 2e-13
Identities = 53/127 (41%), Positives = 63/127 (49%), Gaps = 5/127 (3%)
Query: 1503 KVGGEVKLSISY--KNNKLFIMVMHIRGLQLLQDGND-PDPYVKIYLLPDPQKTTKRKTK 1559
KV GE+ L ISY K L+I V + R L + + D YVK YLLPD + KRKTK
Sbjct: 427 KVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK 486
Query: 1560 VARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQE 1619
+ R NP +NE L Y I L+ R LQLSV F N LGEV I +
Sbjct: 487 I-RTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENP 544
Query: 1620 KTGWFAL 1626
WF L
Sbjct: 545 TDEWFVL 551
Score = 66.6 bits (161), Expect = 2e-10
Identities = 34/104 (32%), Positives = 55/104 (52%)
Query: 1506 GEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTC 1565
G+ K S L + + + L ++ G D +VK YLLPD K TK KT V +K+
Sbjct: 598 GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSV 657
Query: 1566 NPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNI 1609
NP +N ++ GI D++ L+L++ ++ F N+ LG V +
Sbjct: 658 NPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 701
>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
Length = 730
Score = 76.3 bits (186), Expect = 2e-13
Identities = 53/127 (41%), Positives = 63/127 (49%), Gaps = 5/127 (3%)
Query: 1503 KVGGEVKLSISY--KNNKLFIMVMHIRGLQLLQDGND-PDPYVKIYLLPDPQKTTKRKTK 1559
KV GE+ L ISY K L+I V + R L + + D YVK YLLPD + KRKTK
Sbjct: 405 KVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTK 464
Query: 1560 VARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQE 1619
+ R NP +NE L Y I L+ R LQLSV F N LGEV I +
Sbjct: 465 I-RTGTNPEFNETLKYT-ISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENP 522
Query: 1620 KTGWFAL 1626
WF L
Sbjct: 523 TDEWFVL 529
Score = 66.6 bits (161), Expect = 2e-10
Identities = 34/104 (32%), Positives = 55/104 (52%)
Query: 1506 GEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTC 1565
G+ K S L + + + L ++ G D +VK YLLPD K TK KT V +K+
Sbjct: 576 GKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSV 635
Query: 1566 NPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNI 1609
NP +N ++ GI D++ L+L++ ++ F N+ LG V +
Sbjct: 636 NPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRL 679
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 75.5 bits (184), Expect = 4e-13
Identities = 38/102 (37%), Positives = 56/102 (54%)
Query: 1519 LFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGI 1578
L ++ +GL+ + DPYVK++LLP K K KTK R T NP +NE L Y GI
Sbjct: 106 LHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGI 165
Query: 1579 PKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEK 1620
D+ + L+++V E N +GE+ + LR L +Q+K
Sbjct: 166 TDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKK 207
Score = 57.0 bits (136), Expect = 1e-07
Identities = 35/106 (33%), Positives = 54/106 (50%), Gaps = 3/106 (2%)
Query: 1506 GEVKLSISYKNNK--LFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G + LS+SY + + L + ++ L + DPYVK YL PD K +K KT V +K
Sbjct: 253 GRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKK 312
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNI 1609
T NP +NE Y+ I L + L+++V N +G V++
Sbjct: 313 TLNPEFNEEFFYE-IELSTLATKTLEVTVWDYDIGKSNDFIGGVSL 357
>gi|14249614 synaptotagmin-like 1 [Homo sapiens]
Length = 550
Score = 74.7 bits (182), Expect = 7e-13
Identities = 50/129 (38%), Positives = 69/129 (53%), Gaps = 7/129 (5%)
Query: 1503 KVGGEVKLSISYKNN--KLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKV 1560
+V G V ++ Y+ +L + V+ +GL + DPYVK YLLPD Q +KRKT V
Sbjct: 253 QVRGSVHFALHYEPGAAELRVHVIQCQGLAAARRRRS-DPYVKSYLLPDKQ--SKRKTAV 309
Query: 1561 ARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEK 1620
++ NP +NE L Y +P+ +LQ R L LSV + N+ LGEV + L D E
Sbjct: 310 KKRNLNPVFNETLRYS-VPQAELQGRVLSLSVWHRESLGRNIFLGEVEVPLDTWDWGSEP 368
Query: 1621 TGWFALGSR 1629
T W L R
Sbjct: 369 T-WLPLQPR 376
Score = 54.3 bits (129), Expect = 9e-07
Identities = 32/96 (33%), Positives = 54/96 (56%), Gaps = 2/96 (2%)
Query: 1516 NNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVY 1575
+ +L V R L L+ G+ D YV+ ++LPD + ++++T+V R++ +P +N +VY
Sbjct: 409 SGELHFWVKEARDLLPLRAGS-LDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVY 467
Query: 1576 DGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRL 1611
DG DL+Q +LS L + G N LG + L
Sbjct: 468 DGFGPADLRQACAELS-LWDHGALANRQLGGTRLSL 502
>gi|41054864 regulating synaptic membrane exocytosis 1 [Homo sapiens]
Length = 1692
Score = 73.6 bits (179), Expect = 2e-12
Identities = 49/144 (34%), Positives = 75/144 (52%), Gaps = 9/144 (6%)
Query: 1485 GTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGL-QLLQDGNDPDPYVK 1543
G PA T A P G++++ + K +L + V+ R L Q + P PYVK
Sbjct: 1522 GLGPAQLVGRQTLATPAM---GDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVK 1578
Query: 1544 IYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWEN-V 1602
+YLL + K+KT++ARKT +P Y + LV+D P+G + LQ+ V + G ++
Sbjct: 1579 VYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQG----KVLQVIVWGDYGRMDHKC 1634
Query: 1603 LLGEVNIRLRELDLAQEKTGWFAL 1626
+G I L ELDL+ GW+ L
Sbjct: 1635 FMGVAQILLEELDLSSMVIGWYKL 1658
Score = 68.9 bits (167), Expect = 4e-11
Identities = 40/129 (31%), Positives = 66/129 (51%), Gaps = 3/129 (2%)
Query: 1508 VKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCNP 1567
VKL ++L + V+ L DG +PYVK+Y LPD +KR+TK +K P
Sbjct: 748 VKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEP 807
Query: 1568 TYNEMLVYDGIPKGDLQQRELQLSVLSEQGFW--ENVLLGEVNIRLRELDLAQEKTGWFA 1625
+N+ VY + + D ++R L+++V + E+ LGE+ I L E L ++ W+
Sbjct: 808 KWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIEL-ETALLDDEPHWYK 866
Query: 1626 LGSRSHGTL 1634
L + +L
Sbjct: 867 LQTHDESSL 875
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 72.4 bits (176), Expect = 3e-12
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 5/152 (3%)
Query: 1477 LPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGN 1536
L D+ G + + + +GK+ + L ++NN+L + ++ L L G
Sbjct: 119 LKDDDAETGLTDGEEKEEPKEEEKLGKL--QYSLDYDFQNNQLLVGIIQAAELPALDMGG 176
Query: 1537 DPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQ 1596
DPYVK++LLPD +K K +TKV RKT NP +NE + +P +L + L ++V
Sbjct: 177 TSDPYVKVFLLPDKKK--KFETKVHRKTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFD 233
Query: 1597 GFWENVLLGEVNIRLRELDLAQEKTGWFALGS 1628
F ++ ++GE + + +D W L S
Sbjct: 234 RFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQS 265
Score = 57.8 bits (138), Expect = 9e-08
Identities = 30/104 (28%), Positives = 60/104 (57%), Gaps = 3/104 (2%)
Query: 1506 GEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G++ S+ Y KL ++++ + L+ + G DPYVKI+L+ + ++ K+KT + +
Sbjct: 275 GDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKN 334
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEV 1607
T NP YNE ++ +P +Q+ ++ ++VL +N +G+V
Sbjct: 335 TLNPYYNESFSFE-VPFEQIQKVQVVVTVLDYDKIGKNDAIGKV 377
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 72.4 bits (176), Expect = 3e-12
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 5/152 (3%)
Query: 1477 LPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGN 1536
L D+ G + + + +GK+ + L ++NN+L + ++ L L G
Sbjct: 119 LKDDDAETGLTDGEEKEEPKEEEKLGKL--QYSLDYDFQNNQLLVGIIQAAELPALDMGG 176
Query: 1537 DPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQ 1596
DPYVK++LLPD +K K +TKV RKT NP +NE + +P +L + L ++V
Sbjct: 177 TSDPYVKVFLLPDKKK--KFETKVHRKTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFD 233
Query: 1597 GFWENVLLGEVNIRLRELDLAQEKTGWFALGS 1628
F ++ ++GE + + +D W L S
Sbjct: 234 RFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQS 265
Score = 57.8 bits (138), Expect = 9e-08
Identities = 30/104 (28%), Positives = 60/104 (57%), Gaps = 3/104 (2%)
Query: 1506 GEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G++ S+ Y KL ++++ + L+ + G DPYVKI+L+ + ++ K+KT + +
Sbjct: 275 GDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKN 334
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEV 1607
T NP YNE ++ +P +Q+ ++ ++VL +N +G+V
Sbjct: 335 TLNPYYNESFSFE-VPFEQIQKVQVVVTVLDYDKIGKNDAIGKV 377
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 72.4 bits (176), Expect = 3e-12
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 5/152 (3%)
Query: 1477 LPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGN 1536
L D+ G + + + +GK+ + L ++NN+L + ++ L L G
Sbjct: 119 LKDDDAETGLTDGEEKEEPKEEEKLGKL--QYSLDYDFQNNQLLVGIIQAAELPALDMGG 176
Query: 1537 DPDPYVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQ 1596
DPYVK++LLPD +K K +TKV RKT NP +NE + +P +L + L ++V
Sbjct: 177 TSDPYVKVFLLPDKKK--KFETKVHRKTLNPVFNEQFTFK-VPYSELGGKTLVMAVYDFD 233
Query: 1597 GFWENVLLGEVNIRLRELDLAQEKTGWFALGS 1628
F ++ ++GE + + +D W L S
Sbjct: 234 RFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQS 265
Score = 57.8 bits (138), Expect = 9e-08
Identities = 30/104 (28%), Positives = 60/104 (57%), Gaps = 3/104 (2%)
Query: 1506 GEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G++ S+ Y KL ++++ + L+ + G DPYVKI+L+ + ++ K+KT + +
Sbjct: 275 GDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKN 334
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEV 1607
T NP YNE ++ +P +Q+ ++ ++VL +N +G+V
Sbjct: 335 TLNPYYNESFSFE-VPFEQIQKVQVVVTVLDYDKIGKNDAIGKV 377
>gi|45387945 family with sequence similarity 62 (C2 domain containing)
member B [Homo sapiens]
Length = 893
Score = 72.4 bits (176), Expect = 3e-12
Identities = 45/126 (35%), Positives = 79/126 (62%), Gaps = 8/126 (6%)
Query: 1506 GEVKLSI--SYKNNKLFIMVMHIRGL-QLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVAR 1562
G+++L+I S + NKL ++V R L +DG+DP YV++YLLPD +++ +RKT V++
Sbjct: 760 GQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDP--YVRMYLLPDKRRSGRRKTHVSK 817
Query: 1563 KTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFW--ENVLLGEVNIRLRELDLAQEK 1620
KT NP +++ + + ++Q+R L ++V + GF + LLG+V + L +LA+
Sbjct: 818 KTLNPVFDQSFDF-SVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGW 876
Query: 1621 TGWFAL 1626
T W+ L
Sbjct: 877 TQWYDL 882
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 71.6 bits (174), Expect = 6e-12
Identities = 41/120 (34%), Positives = 68/120 (56%), Gaps = 5/120 (4%)
Query: 1506 GEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G+++ S+ Y + N+L + V+ L L G DPYVK++LLPD +K K +TKV RK
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKK--KYETKVHRK 198
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGW 1623
T NP +NE + +P +L + L +++ F ++ ++GEV + + +DL Q W
Sbjct: 199 TLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEW 257
Score = 57.8 bits (138), Expect = 9e-08
Identities = 31/104 (29%), Positives = 60/104 (57%), Gaps = 3/104 (2%)
Query: 1506 GEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G++ S+ Y KL + ++ + L+ + G DPYVKI+L+ + ++ K+KT V +K
Sbjct: 272 GDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKK 331
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEV 1607
T NP +NE ++ IP +Q+ ++ ++VL +N +G++
Sbjct: 332 TLNPYFNESFSFE-IPFEQIQKVQVVVTVLDYDKLGKNEAIGKI 374
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 71.6 bits (174), Expect = 6e-12
Identities = 41/120 (34%), Positives = 68/120 (56%), Gaps = 5/120 (4%)
Query: 1506 GEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G+++ S+ Y + N+L + V+ L L G DPYVK++LLPD +K K +TKV RK
Sbjct: 141 GKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKK--KYETKVHRK 198
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIRLRELDLAQEKTGW 1623
T NP +NE + +P +L + L +++ F ++ ++GEV + + +DL Q W
Sbjct: 199 TLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEW 257
Score = 57.8 bits (138), Expect = 9e-08
Identities = 31/104 (29%), Positives = 60/104 (57%), Gaps = 3/104 (2%)
Query: 1506 GEVKLSISY--KNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARK 1563
G++ S+ Y KL + ++ + L+ + G DPYVKI+L+ + ++ K+KT V +K
Sbjct: 272 GDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKK 331
Query: 1564 TCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEV 1607
T NP +NE ++ IP +Q+ ++ ++VL +N +G++
Sbjct: 332 TLNPYFNESFSFE-IPFEQIQKVQVVVTVLDYDKLGKNEAIGKI 374
>gi|154354983 regulating synaptic membrane exocytosis 2 isoform a
[Homo sapiens]
Length = 1349
Score = 71.2 bits (173), Expect = 8e-12
Identities = 49/145 (33%), Positives = 78/145 (53%), Gaps = 11/145 (7%)
Query: 1485 GTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGND--PDPYV 1542
G PA T A P G++++ + K +L + ++ RGL +++ G+ P PYV
Sbjct: 1179 GLGPAQLVGRQTLATPAM---GDIQVGMMDKKGQLEVEIIRARGL-VVKPGSKTLPAPYV 1234
Query: 1543 KIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWEN- 1601
K+YLL + K+KTKVARKT P Y ++L ++ P+G + LQ+ V + G ++
Sbjct: 1235 KVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQG----KVLQIIVWGDYGRMDHK 1290
Query: 1602 VLLGEVNIRLRELDLAQEKTGWFAL 1626
+G I L EL+L+ GWF L
Sbjct: 1291 SFMGVAQILLDELELSNMVIGWFKL 1315
Score = 69.7 bits (169), Expect = 2e-11
Identities = 37/130 (28%), Positives = 69/130 (53%), Gaps = 3/130 (2%)
Query: 1507 EVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDPYVKIYLLPDPQKTTKRKTKVARKTCN 1566
++KL ++L + ++ + L +DG +PYVKIY LPD KR+TK +KT
Sbjct: 748 QIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTLE 807
Query: 1567 PTYNEMLVYDGIPKGDLQQRELQLSVLSEQGF--WENVLLGEVNIRLRELDLAQEKTGWF 1624
P +N+ +Y + + + ++R L++++ + E+ LGE+ I L E L ++ W+
Sbjct: 808 PKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIEL-ETALLDDEPHWY 866
Query: 1625 ALGSRSHGTL 1634
L + +L
Sbjct: 867 KLQTHDVSSL 876
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,638,098
Number of Sequences: 37866
Number of extensions: 3503855
Number of successful extensions: 12464
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 203
Number of HSP's that attempted gapping in prelim test: 11619
Number of HSP's gapped (non-prelim): 859
length of query: 1634
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1518
effective length of database: 13,855,062
effective search space: 21031984116
effective search space used: 21031984116
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.