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Search of human proteins with 194018513
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194018513 patched domain containing 3 [Homo sapiens]
(767 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194018513 patched domain containing 3 [Homo sapiens] 1580 0.0
gi|148271104 patched domain containing 1 [Homo sapiens] 189 6e-48
gi|148277106 hypothetical protein LOC442213 [Homo sapiens] 154 2e-37
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 108 2e-23
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 99 1e-20
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 99 1e-20
gi|134254450 patched isoform S [Homo sapiens] 84 4e-16
gi|134254435 patched isoform S [Homo sapiens] 84 4e-16
gi|134254468 patched isoform S [Homo sapiens] 84 4e-16
gi|134254452 patched isoform S [Homo sapiens] 84 4e-16
gi|134254432 patched isoform L' [Homo sapiens] 84 4e-16
gi|134254466 patched isoform M [Homo sapiens] 84 4e-16
gi|134254446 patched isoform L [Homo sapiens] 84 4e-16
gi|52145305 patched 2 [Homo sapiens] 79 1e-14
gi|25952134 dispatched A [Homo sapiens] 62 3e-09
gi|149274653 patched domain containing 2 [Homo sapiens] 50 8e-06
gi|195963316 PWWP domain containing 2A isoform b [Homo sapiens] 46 1e-04
gi|153791982 PWWP domain containing 2A isoform a [Homo sapiens] 46 1e-04
gi|153792074 proline rich 12 [Homo sapiens] 46 1e-04
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 45 3e-04
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho... 44 6e-04
gi|110611233 alpha 1 type XVIII collagen isoform 2 precursor [Ho... 44 6e-04
gi|110611235 alpha 1 type XVIII collagen isoform 1 precursor [Ho... 44 6e-04
gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase iso... 43 0.001
gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isofo... 43 0.001
gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens] 42 0.002
gi|154816198 transcription elongation factor B polypeptide 3C-li... 42 0.002
gi|156938279 transcription elongation factor B polypeptide 3C [H... 42 0.002
gi|224994173 roundabout 1 isoform d [Homo sapiens] 42 0.003
gi|224994171 roundabout 1 isoform c [Homo sapiens] 42 0.003
>gi|194018513 patched domain containing 3 [Homo sapiens]
Length = 767
Score = 1580 bits (4090), Expect = 0.0
Identities = 767/767 (100%), Positives = 767/767 (100%)
Query: 1 MPWVEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPL 60
MPWVEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPL
Sbjct: 1 MPWVEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPL 60
Query: 61 ASEQDAPLPEGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEPTAICRHRHRCHTDCLE 120
ASEQDAPLPEGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEPTAICRHRHRCHTDCLE
Sbjct: 61 ASEQDAPLPEGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEPTAICRHRHRCHTDCLE 120
Query: 121 GLLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKA 180
GLLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKA
Sbjct: 121 GLLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKA 180
Query: 181 ERRFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQDLR 240
ERRFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQDLR
Sbjct: 181 ERRFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQDLR 240
Query: 241 VAREKGSQIQYQQVCARYRALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGF 300
VAREKGSQIQYQQVCARYRALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGF
Sbjct: 241 VAREKGSQIQYQQVCARYRALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGF 300
Query: 301 FGGYILGGSLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILALK 360
FGGYILGGSLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILALK
Sbjct: 301 FGGYILGGSLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILALK 360
Query: 361 KIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVI 420
KIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVI
Sbjct: 361 KIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVI 420
Query: 421 SAFLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMS 480
SAFLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMS
Sbjct: 421 SAFLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMS 480
Query: 481 NVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMAL 540
NVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMAL
Sbjct: 481 NVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMAL 540
Query: 541 DGKREVVCLCWLKKADPKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRDYFGPFLTRSE 600
DGKREVVCLCWLKKADPKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRDYFGPFLTRSE
Sbjct: 541 DGKREVVCLCWLKKADPKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRDYFGPFLTRSE 600
Query: 601 SKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVI 660
SKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVI
Sbjct: 601 SKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVI 660
Query: 661 VTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYLKGNSQDPNEKNTFMN 720
VTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYLKGNSQDPNEKNTFMN
Sbjct: 661 VTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYLKGNSQDPNEKNTFMN 720
Query: 721 NIPDFLSNFPNFQHDINISSSNEIISSRGFIQTTDVSSSAKKKILLF 767
NIPDFLSNFPNFQHDINISSSNEIISSRGFIQTTDVSSSAKKKILLF
Sbjct: 721 NIPDFLSNFPNFQHDINISSSNEIISSRGFIQTTDVSSSAKKKILLF 767
>gi|148271104 patched domain containing 1 [Homo sapiens]
Length = 888
Score = 189 bits (481), Expect = 6e-48
Identities = 155/655 (23%), Positives = 288/655 (43%), Gaps = 37/655 (5%)
Query: 123 LSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKAER 182
L F LG + +HP F AP++++ LG F EE +E P S AK ER
Sbjct: 10 LRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRY--QVEESVEHLLAPQHSLAKIER 67
Query: 183 RFVQGHFTTNDSYRFSASRRSTEANFVSLLVVSYSDS-LLDPATFAEVSKLDGAVQDLRV 241
V F N S S T + ++V S+ + +LD + KL AV ++V
Sbjct: 68 NLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLHAAVTKIQV 127
Query: 242 AREKGSQIQYQQVCARYR-ALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGF 300
R G + +C C+ + + ++ + +F H
Sbjct: 128 PRP-GFNYTFAHICILNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHLKDGRAV 186
Query: 301 FGGYILGG-SLGMGQLLLRAKAMRLLYYLKTEDPEYDVQSKQWLTHLLDQFTNIKNILAL 359
+ G+ LGG ++ + A+A++L YYL++ + D+ +++W + D + +
Sbjct: 187 YNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVRLFQK--SN 244
Query: 360 KKIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGV 419
K+++ +TS S + +F+ TS + IL++ A+ C DC+R+K + G+
Sbjct: 245 SKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGL 304
Query: 420 ISAFLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERM 479
++ LA ++ G++ G + PF++LG G+ F M+S+W KT ++ER
Sbjct: 305 VTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKERT 364
Query: 480 SNVYSKAAVSITITTITNILALYTGI--MSSFRSVQCFCIYTGMTLLFCYFYNITCFGAF 537
+ VY+ + +S ++TT ++ G ++ + + FC + + + F Y Y ++ +G+
Sbjct: 365 AAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIFFNYLYVLSFYGSS 424
Query: 538 MALDG------KREVVCLCWLK----KADPKWPSFKKFCCFPFGSVPDEHGT--DIHPIS 585
+ G + + C K + P W F F + E + H +
Sbjct: 425 LVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAEGEEANTYESHLLV 484
Query: 586 LFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNV 645
F + Y+ ++T + K FVV Y++YI ++ G V EG DL N+ + + Y
Sbjct: 485 CFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTA 544
Query: 646 EENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYL 705
++ YFS+Y P + + + ++YW+ V++ + TK F + W ++Y+ YL
Sbjct: 545 QQKYFSNYSPVIGFYIYESIEYWNTSVQEDVLEYTKGF---------VRISWFESYLNYL 595
Query: 706 -KGNSQDPNEKNTFMNNIPDFLSNFPNFQHDINISSSNEIISSRGFIQTTDVSSS 759
K N K F + + + P F H +II S+ + DV +S
Sbjct: 596 RKLNVSTGLPKKNFTDMLRNSFLKAPQFSH-----FQEDIIFSKKYNDEVDVVAS 645
>gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
Length = 829
Score = 154 bits (390), Expect = 2e-37
Identities = 148/647 (22%), Positives = 263/647 (40%), Gaps = 95/647 (14%)
Query: 130 LGWQVGAHPWIFLLAPLMLTAALGTGFL--YLPKDEEEDLEEHYTPVGSPAKAERRFVQG 187
LG V HP FL P +LT G L + P E DLE P S AK ER
Sbjct: 17 LGLCVSRHPVFFLTVPAVLTITFGLSALNRFQP---EGDLERLVAPSHSLAKIERSLASS 73
Query: 188 HFTTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQDLRVAREKGS 247
F + S S T + ++ LL P + + +G +Q R E
Sbjct: 74 LFPLDQSKSQLYSDLHTPGRYGRVI-------LLSPTGDNILLQAEGILQTHRAVLEM-- 124
Query: 248 QIQYQQVCARYRALCVPPNPILYAWQVNKTLNLSSISFPAYNHGRHPLYLTGFFGGYILG 307
GR+ F G+ LG
Sbjct: 125 -----------------------------------------KDGRNS------FIGHQLG 137
Query: 308 GSLGM----GQLLLRAKAMRLLYYLKTE-DPEYDVQSKQWLTHLLDQFTNIKNILALKKI 362
G + + Q + A+A+++ YYL+T D+ ++W ++ +++
Sbjct: 138 GVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCKLIRKLQE--EHQEL 195
Query: 363 EVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVISA 422
++ S S +F TS+ ++ +LI+ A S DC+R+K + GV++
Sbjct: 196 QLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTV 255
Query: 423 FLAVVSGFGLLLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMSNV 482
+++++ G+ + + PF +G G +F ++S W +T ++R+++
Sbjct: 256 CISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTKENLPFKDRIADA 315
Query: 483 YSKAAVSITITTITNILALYTGI--MSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMAL 540
YS V+ T+T+ + G ++ +V+ FC +++L YFY + FG+ +
Sbjct: 316 YSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVF 375
Query: 541 DGKREV-----VCLCWLKKAD-----PKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRD 590
G+ E + C + A+ P W S + + H I F R+
Sbjct: 376 AGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLRE 435
Query: 591 YFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYF 650
++ ++T K FVV +Y++Y S GC + +G ++ NL + DS Y V++ YF
Sbjct: 436 HYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYF 495
Query: 651 SDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYVDKNLTEFWLDAYVQYLKGNSQ 710
S+Y P + V + ++YW+ V+ L F W++ Y Q+LK ++
Sbjct: 496 SNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGF---------TAVSWVEQYYQFLKVSNV 546
Query: 711 DPNEKNTFMNNIPDFLSNFPNFQH---DINISSSNE---IISSRGFI 751
N K+ F++ + P FQH DI S + + II+SR ++
Sbjct: 547 SANNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYL 593
>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
Length = 1278
Score = 108 bits (270), Expect = 2e-23
Identities = 88/355 (24%), Positives = 159/355 (44%), Gaps = 38/355 (10%)
Query: 326 YYLKTEDPEYDVQSKQWLTHLLDQFTNIKN------ILALKKIEVVHFTSLSRQLEFEAT 379
YY TE + +++ W ++ N KN A + IE L+R+ + +
Sbjct: 570 YYNDTEKLQ---RAQAWEKEFINFVKNYKNPNLTISFTAERSIE----DELNRESDSDVF 622
Query: 380 SVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVISAFLAVVSGFGLLLHIGVP 439
+V + YI + L + SC R + +K+ + G++ +V G+ +IG+P
Sbjct: 623 TVVISYAIMFLYISLALGHIKSCRRL-LVDSKVSLGIAGILIVLSSVACSLGVFSYIGLP 681
Query: 440 FVIIVANS-PFLILGVGVDDMFIMISAWHKTNL--ADDIRERMSNVYSKAAVSITITTIT 496
+IV PFL+L VGVD++FI++ A+ + + + +++ V + A S+ +++ +
Sbjct: 682 LTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFS 741
Query: 497 NILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKREVVCLCWLKKAD 556
+A + G +S +V F ++ G+ + + ITCF + + LD KR+
Sbjct: 742 ETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQ----------- 790
Query: 557 PKWPSFKKFCCFPFGSVPDEHGTDIHP----ISLFFRDYFGPFLTRSESKYFVVFIYVLY 612
+ FCC E GT + + FF++ + P L + + V+ I+V
Sbjct: 791 -EKNRLDIFCCVRGA----EDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGV 845
Query: 613 IISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVIVTKKVDY 667
+ SI V GLD DDSY+ YF Y GP V ++ + DY
Sbjct: 846 LSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL-HAGPPVYFVLEEGHDY 899
>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo
sapiens]
Length = 1332
Score = 99.4 bits (246), Expect = 1e-20
Identities = 130/598 (21%), Positives = 244/598 (40%), Gaps = 85/598 (14%)
Query: 122 LLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKAE 181
LL + FQ G V + P L+ ++ AL G ++ + D E ++ S A++E
Sbjct: 336 LLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFT--ELTTDPVELWSAPNSQARSE 393
Query: 182 RRFVQGHF----TTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQ 237
+ F HF TN + +R S + + L ++S +LD E+ +L ++
Sbjct: 394 KAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFS-GILDLDLLLELLELQERLR 452
Query: 238 DLRV-AREKGSQIQYQQVCARYRAL----------CVPPNPILYAWQVNKTLNLSSISFP 286
L+V + E I Q +C Y L C+ N +L +Q N+TL L + +
Sbjct: 453 HLQVWSPEAQRNISLQDIC--YAPLNPDNTSLYDCCI--NSLLQYFQNNRTLLLLTANQT 508
Query: 287 AYNHGR------HPLYLTGFFGGYILGGSLGM--------------------GQLLLRAK 320
H LY + G +L + G+ A+
Sbjct: 509 LMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAE 568
Query: 321 AMRLLYYLKTE---DPEYDVQSKQWLTHLLDQFTNIKNILALKKIEVVHFTSLSRQLEFE 377
A+ + + L DP Q+K W L++ + +A +V S + E
Sbjct: 569 ALIMTFSLNNYPAGDPRL-AQAKLWEEAFLEEMRAFQRRMA-GMFQVTFMAERSLEDEIN 626
Query: 378 ATSVTVIPVFHLAYILIILFAVTSCFRFDC-----IRNKMCVAAFGVISAFLAVVSGFGL 432
T+ +P+F +YI+I L+ + + + +K + GV AV++ G
Sbjct: 627 RTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGF 686
Query: 433 LLHIGV-PFVIIVANSPFLILGVGVDDMFIMISAWHKT-NLADDIRE-RMSNVYSKAAVS 489
++G+ ++I+ PFL+L VG D++FI + + + + RE + + A S
Sbjct: 687 FSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPS 746
Query: 490 ITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKREV--- 546
+ + +++ + + G ++ +V+ F + +G+ ++ + ++ F A ++LD KR+
Sbjct: 747 MLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASR 806
Query: 547 --VCLCWLKKADPKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRDYFGPFLTRSESKYF 604
VC C + P P G + + FF+ + PFL ++
Sbjct: 807 LDVCCCVKPQELP----------------PPGQGEGL--LLGFFQKAYAPFLLHWITRGV 848
Query: 605 VVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVIVT 662
V+ +++ S+Y H+ GLD DSY+ YF YF + G V + T
Sbjct: 849 VLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYF-EVGAPVYFVTT 905
>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo
sapiens]
Length = 1359
Score = 99.4 bits (246), Expect = 1e-20
Identities = 130/598 (21%), Positives = 244/598 (40%), Gaps = 85/598 (14%)
Query: 122 LLSRTFQWLGWQVGAHPWIFLLAPLMLTAALGTGFLYLPKDEEEDLEEHYTPVGSPAKAE 181
LL + FQ G V + P L+ ++ AL G ++ + D E ++ S A++E
Sbjct: 336 LLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFT--ELTTDPVELWSAPNSQARSE 393
Query: 182 RRFVQGHF----TTNDSYRFSASRRSTEANFVSLLVVSYSDSLLDPATFAEVSKLDGAVQ 237
+ F HF TN + +R S + + L ++S +LD E+ +L ++
Sbjct: 394 KAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFS-GILDLDLLLELLELQERLR 452
Query: 238 DLRV-AREKGSQIQYQQVCARYRAL----------CVPPNPILYAWQVNKTLNLSSISFP 286
L+V + E I Q +C Y L C+ N +L +Q N+TL L + +
Sbjct: 453 HLQVWSPEAQRNISLQDIC--YAPLNPDNTSLYDCCI--NSLLQYFQNNRTLLLLTANQT 508
Query: 287 AYNHGR------HPLYLTGFFGGYILGGSLGM--------------------GQLLLRAK 320
H LY + G +L + G+ A+
Sbjct: 509 LMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAE 568
Query: 321 AMRLLYYLKTE---DPEYDVQSKQWLTHLLDQFTNIKNILALKKIEVVHFTSLSRQLEFE 377
A+ + + L DP Q+K W L++ + +A +V S + E
Sbjct: 569 ALIMTFSLNNYPAGDPRL-AQAKLWEEAFLEEMRAFQRRMA-GMFQVTFMAERSLEDEIN 626
Query: 378 ATSVTVIPVFHLAYILIILFAVTSCFRFDC-----IRNKMCVAAFGVISAFLAVVSGFGL 432
T+ +P+F +YI+I L+ + + + +K + GV AV++ G
Sbjct: 627 RTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGF 686
Query: 433 LLHIGV-PFVIIVANSPFLILGVGVDDMFIMISAWHKT-NLADDIRE-RMSNVYSKAAVS 489
++G+ ++I+ PFL+L VG D++FI + + + + RE + + A S
Sbjct: 687 FSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPS 746
Query: 490 ITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKREV--- 546
+ + +++ + + G ++ +V+ F + +G+ ++ + ++ F A ++LD KR+
Sbjct: 747 MLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASR 806
Query: 547 --VCLCWLKKADPKWPSFKKFCCFPFGSVPDEHGTDIHPISLFFRDYFGPFLTRSESKYF 604
VC C + P P G + + FF+ + PFL ++
Sbjct: 807 LDVCCCVKPQELP----------------PPGQGEGL--LLGFFQKAYAPFLLHWITRGV 848
Query: 605 VVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVIVT 662
V+ +++ S+Y H+ GLD DSY+ YF YF + G V + T
Sbjct: 849 VLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYF-EVGAPVYFVTT 905
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 84.3 bits (207), Expect = 4e-16
Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 20/246 (8%)
Query: 316 LLRAKAMRLLYYLKTEDPEYD-VQSKQWLTHLL---DQFTNIKNILALKKIEVVHFT--- 368
L+ A A++ ++ L T Y+ + ++++H+ D+ I +EVVH +
Sbjct: 203 LVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQ 262
Query: 369 -SLSRQLEFEAT-------SVTVIPVFHLA--YILIILFAVTSCFRFDCIRNKMCVAAFG 418
S + L F T S + + V +A Y+L++ +A + R+DC +++ V G
Sbjct: 263 NSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAG 322
Query: 419 VISAFLAVVSGFGLLLHIGVPFVIIVAN-SPFLILGVGVDDMFIMISAWHKT--NLADDI 475
V+ L+V +G GL IG+ F PFL LGVGVDD+F++ A+ +T N
Sbjct: 323 VLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPF 382
Query: 476 RERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFG 535
+R + S+ +T+I+N+ A + + +++ F + + ++F + + F
Sbjct: 383 EDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFP 442
Query: 536 AFMALD 541
A +++D
Sbjct: 443 AILSMD 448
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%)
Query: 584 ISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYF 643
+S F ++ PFL + ++K V+F+++ + S+YG V++GLDL ++ ++ +
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 644 NVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYV----DKNLTEFWLD 699
+ YFS Y M IVT+K DY +++ L + + F YV +K L + WL
Sbjct: 641 AAQFKYFSFYN---MYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 695
Query: 700 AYVQYLKG 707
+ +L+G
Sbjct: 696 YFRDWLQG 703
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 84.3 bits (207), Expect = 4e-16
Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 20/246 (8%)
Query: 316 LLRAKAMRLLYYLKTEDPEYD-VQSKQWLTHLL---DQFTNIKNILALKKIEVVHFT--- 368
L+ A A++ ++ L T Y+ + ++++H+ D+ I +EVVH +
Sbjct: 203 LVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQ 262
Query: 369 -SLSRQLEFEAT-------SVTVIPVFHLA--YILIILFAVTSCFRFDCIRNKMCVAAFG 418
S + L F T S + + V +A Y+L++ +A + R+DC +++ V G
Sbjct: 263 NSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAG 322
Query: 419 VISAFLAVVSGFGLLLHIGVPFVIIVAN-SPFLILGVGVDDMFIMISAWHKT--NLADDI 475
V+ L+V +G GL IG+ F PFL LGVGVDD+F++ A+ +T N
Sbjct: 323 VLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPF 382
Query: 476 RERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFG 535
+R + S+ +T+I+N+ A + + +++ F + + ++F + + F
Sbjct: 383 EDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFP 442
Query: 536 AFMALD 541
A +++D
Sbjct: 443 AILSMD 448
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%)
Query: 584 ISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYF 643
+S F ++ PFL + ++K V+F+++ + S+YG V++GLDL ++ ++ +
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 644 NVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYV----DKNLTEFWLD 699
+ YFS Y M IVT+K DY +++ L + + F YV +K L + WL
Sbjct: 641 AAQFKYFSFYN---MYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 695
Query: 700 AYVQYLKG 707
+ +L+G
Sbjct: 696 YFRDWLQG 703
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 84.3 bits (207), Expect = 4e-16
Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 20/246 (8%)
Query: 316 LLRAKAMRLLYYLKTEDPEYD-VQSKQWLTHLL---DQFTNIKNILALKKIEVVHFT--- 368
L+ A A++ ++ L T Y+ + ++++H+ D+ I +EVVH +
Sbjct: 203 LVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQ 262
Query: 369 -SLSRQLEFEAT-------SVTVIPVFHLA--YILIILFAVTSCFRFDCIRNKMCVAAFG 418
S + L F T S + + V +A Y+L++ +A + R+DC +++ V G
Sbjct: 263 NSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAG 322
Query: 419 VISAFLAVVSGFGLLLHIGVPFVIIVAN-SPFLILGVGVDDMFIMISAWHKT--NLADDI 475
V+ L+V +G GL IG+ F PFL LGVGVDD+F++ A+ +T N
Sbjct: 323 VLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPF 382
Query: 476 RERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFG 535
+R + S+ +T+I+N+ A + + +++ F + + ++F + + F
Sbjct: 383 EDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFP 442
Query: 536 AFMALD 541
A +++D
Sbjct: 443 AILSMD 448
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%)
Query: 584 ISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYF 643
+S F ++ PFL + ++K V+F+++ + S+YG V++GLDL ++ ++ +
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 644 NVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYV----DKNLTEFWLD 699
+ YFS Y M IVT+K DY +++ L + + F YV +K L + WL
Sbjct: 641 AAQFKYFSFYN---MYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 695
Query: 700 AYVQYLKG 707
+ +L+G
Sbjct: 696 YFRDWLQG 703
>gi|134254452 patched isoform S [Homo sapiens]
Length = 1296
Score = 84.3 bits (207), Expect = 4e-16
Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 20/246 (8%)
Query: 316 LLRAKAMRLLYYLKTEDPEYD-VQSKQWLTHLL---DQFTNIKNILALKKIEVVHFT--- 368
L+ A A++ ++ L T Y+ + ++++H+ D+ I +EVVH +
Sbjct: 203 LVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQ 262
Query: 369 -SLSRQLEFEAT-------SVTVIPVFHLA--YILIILFAVTSCFRFDCIRNKMCVAAFG 418
S + L F T S + + V +A Y+L++ +A + R+DC +++ V G
Sbjct: 263 NSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAG 322
Query: 419 VISAFLAVVSGFGLLLHIGVPFVIIVAN-SPFLILGVGVDDMFIMISAWHKT--NLADDI 475
V+ L+V +G GL IG+ F PFL LGVGVDD+F++ A+ +T N
Sbjct: 323 VLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPF 382
Query: 476 RERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFG 535
+R + S+ +T+I+N+ A + + +++ F + + ++F + + F
Sbjct: 383 EDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFP 442
Query: 536 AFMALD 541
A +++D
Sbjct: 443 AILSMD 448
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%)
Query: 584 ISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYF 643
+S F ++ PFL + ++K V+F+++ + S+YG V++GLDL ++ ++ +
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 644 NVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYV----DKNLTEFWLD 699
+ YFS Y M IVT+K DY +++ L + + F YV +K L + WL
Sbjct: 641 AAQFKYFSFYN---MYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 695
Query: 700 AYVQYLKG 707
+ +L+G
Sbjct: 696 YFRDWLQG 703
>gi|134254432 patched isoform L' [Homo sapiens]
Length = 1446
Score = 84.3 bits (207), Expect = 4e-16
Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 20/246 (8%)
Query: 316 LLRAKAMRLLYYLKTEDPEYD-VQSKQWLTHLL---DQFTNIKNILALKKIEVVHFT--- 368
L+ A A++ ++ L T Y+ + ++++H+ D+ I +EVVH +
Sbjct: 353 LVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQ 412
Query: 369 -SLSRQLEFEAT-------SVTVIPVFHLA--YILIILFAVTSCFRFDCIRNKMCVAAFG 418
S + L F T S + + V +A Y+L++ +A + R+DC +++ V G
Sbjct: 413 NSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAG 472
Query: 419 VISAFLAVVSGFGLLLHIGVPFVIIVAN-SPFLILGVGVDDMFIMISAWHKT--NLADDI 475
V+ L+V +G GL IG+ F PFL LGVGVDD+F++ A+ +T N
Sbjct: 473 VLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPF 532
Query: 476 RERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFG 535
+R + S+ +T+I+N+ A + + +++ F + + ++F + + F
Sbjct: 533 EDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFP 592
Query: 536 AFMALD 541
A +++D
Sbjct: 593 AILSMD 598
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%)
Query: 584 ISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYF 643
+S F ++ PFL + ++K V+F+++ + S+YG V++GLDL ++ ++ +
Sbjct: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790
Query: 644 NVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYV----DKNLTEFWLD 699
+ YFS Y M IVT+K DY +++ L + + F YV +K L + WL
Sbjct: 791 AAQFKYFSFYN---MYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 845
Query: 700 AYVQYLKG 707
+ +L+G
Sbjct: 846 YFRDWLQG 853
>gi|134254466 patched isoform M [Homo sapiens]
Length = 1381
Score = 84.3 bits (207), Expect = 4e-16
Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 20/246 (8%)
Query: 316 LLRAKAMRLLYYLKTEDPEYD-VQSKQWLTHLL---DQFTNIKNILALKKIEVVHFT--- 368
L+ A A++ ++ L T Y+ + ++++H+ D+ I +EVVH +
Sbjct: 288 LVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQ 347
Query: 369 -SLSRQLEFEAT-------SVTVIPVFHLA--YILIILFAVTSCFRFDCIRNKMCVAAFG 418
S + L F T S + + V +A Y+L++ +A + R+DC +++ V G
Sbjct: 348 NSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAG 407
Query: 419 VISAFLAVVSGFGLLLHIGVPFVIIVAN-SPFLILGVGVDDMFIMISAWHKT--NLADDI 475
V+ L+V +G GL IG+ F PFL LGVGVDD+F++ A+ +T N
Sbjct: 408 VLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPF 467
Query: 476 RERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFG 535
+R + S+ +T+I+N+ A + + +++ F + + ++F + + F
Sbjct: 468 EDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFP 527
Query: 536 AFMALD 541
A +++D
Sbjct: 528 AILSMD 533
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%)
Query: 584 ISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYF 643
+S F ++ PFL + ++K V+F+++ + S+YG V++GLDL ++ ++ +
Sbjct: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
Query: 644 NVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYV----DKNLTEFWLD 699
+ YFS Y M IVT+K DY +++ L + + F YV +K L + WL
Sbjct: 726 AAQFKYFSFYN---MYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 780
Query: 700 AYVQYLKG 707
+ +L+G
Sbjct: 781 YFRDWLQG 788
>gi|134254446 patched isoform L [Homo sapiens]
Length = 1447
Score = 84.3 bits (207), Expect = 4e-16
Identities = 62/246 (25%), Positives = 120/246 (48%), Gaps = 20/246 (8%)
Query: 316 LLRAKAMRLLYYLKTEDPEYD-VQSKQWLTHLL---DQFTNIKNILALKKIEVVHFT--- 368
L+ A A++ ++ L T Y+ + ++++H+ D+ I +EVVH +
Sbjct: 354 LVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQ 413
Query: 369 -SLSRQLEFEAT-------SVTVIPVFHLA--YILIILFAVTSCFRFDCIRNKMCVAAFG 418
S + L F T S + + V +A Y+L++ +A + R+DC +++ V G
Sbjct: 414 NSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAG 473
Query: 419 VISAFLAVVSGFGLLLHIGVPFVIIVAN-SPFLILGVGVDDMFIMISAWHKT--NLADDI 475
V+ L+V +G GL IG+ F PFL LGVGVDD+F++ A+ +T N
Sbjct: 474 VLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPF 533
Query: 476 RERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFG 535
+R + S+ +T+I+N+ A + + +++ F + + ++F + + F
Sbjct: 534 EDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFP 593
Query: 536 AFMALD 541
A +++D
Sbjct: 594 AILSMD 599
Score = 60.5 bits (145), Expect = 6e-09
Identities = 37/128 (28%), Positives = 68/128 (53%), Gaps = 9/128 (7%)
Query: 584 ISLFFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYF 643
+S F ++ PFL + ++K V+F+++ + S+YG V++GLDL ++ ++ +
Sbjct: 732 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 791
Query: 644 NVEENYFSDYGPRVMVIVTKKVDYWDKDVRQKLENCTKIFEKNVYV----DKNLTEFWLD 699
+ YFS Y M IVT+K DY +++ L + + F YV +K L + WL
Sbjct: 792 AAQFKYFSFYN---MYIVTQKADY--PNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLH 846
Query: 700 AYVQYLKG 707
+ +L+G
Sbjct: 847 YFRDWLQG 854
>gi|52145305 patched 2 [Homo sapiens]
Length = 1203
Score = 79.3 bits (194), Expect = 1e-14
Identities = 43/155 (27%), Positives = 80/155 (51%), Gaps = 1/155 (0%)
Query: 391 YILIILFAVTSCFRFDCIRNKMCVAAFGVISAFLAVVSGFGLLLHIGVPFVIIVANS-PF 449
Y+L++ +A + R+DC +++ V GV+ LAV SG GL +G+ F PF
Sbjct: 402 YLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPF 461
Query: 450 LILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVSITITTITNILALYTGIMSSF 509
L LG+GVDD+F++ A+ + ++ERM + S+ +T+I N+ A +
Sbjct: 462 LALGIGVDDVFLLAHAFTEALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPI 521
Query: 510 RSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKR 544
+++ F + + + + + F A ++LD +R
Sbjct: 522 PALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRR 556
Score = 36.2 bits (82), Expect = 0.12
Identities = 30/126 (23%), Positives = 52/126 (41%), Gaps = 10/126 (7%)
Query: 587 FFRDYFGPFLTRSESKYFVVFIYVLYIISSIYGCFHVQEGLDLRNLASDDSYITPYFNVE 646
F R F P L +S +K V+ ++ + S+YG VQ+GL L ++ + + + +
Sbjct: 671 FARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQ 730
Query: 647 ENYFSDYGPRVMVIVTKKVDYWDK-----DVRQKLENCTKIFEKNVYVDKNLTEFWLDAY 701
YFS Y V ++ DY D+ Q+ + + WL Y
Sbjct: 731 LRYFSLY--EVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPA---TQAPRTWLHYY 785
Query: 702 VQYLKG 707
+L+G
Sbjct: 786 RNWLQG 791
>gi|25952134 dispatched A [Homo sapiens]
Length = 1524
Score = 61.6 bits (148), Expect = 3e-09
Identities = 44/198 (22%), Positives = 84/198 (42%), Gaps = 12/198 (6%)
Query: 347 LDQFTNIKNILALKKIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFD 406
LD F N + + I + F + TV P + +L+++ T
Sbjct: 469 LDNFENWNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFIT 528
Query: 407 CIRNKMCVAAFGVISAFLAVVSGFGLLLHIGV-PFVIIVANSPFLILGVGVDDMFIMISA 465
+ F +IS+ + + ++ H PF+ + A +++G+G DD F++
Sbjct: 529 LM------TMFAIISSLIVSYFLYRVVFHFEFFPFMNLTAL--IILVGIGADDAFVLCDV 580
Query: 466 WHKTNLAD---DIRERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMT 522
W+ T + E +S AA+S+ +T+ T A Y +S+ +++CF +Y G
Sbjct: 581 WNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTA 640
Query: 523 LLFCYFYNITCFGAFMAL 540
+L Y +T A + L
Sbjct: 641 ILVNYVLMVTWLPAVVVL 658
>gi|149274653 patched domain containing 2 [Homo sapiens]
Length = 1392
Score = 50.1 bits (118), Expect = 8e-06
Identities = 35/152 (23%), Positives = 73/152 (48%), Gaps = 12/152 (7%)
Query: 392 ILIILFAVTSCFRFDCIRNKMCVAAFGVISAFLAVVSGFGLLLHI--GVPFV-IIVANSP 448
I +++ +TSC F ++ FG+ S L+ + L H+ G+ ++ I+ +
Sbjct: 473 IAALVYILTSCSVF--------LSFFGIASIGLSCLVAL-FLYHVVFGIQYLGILNGVAA 523
Query: 449 FLILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVSITITTITNILALYTGIMSS 508
F+I+G+GVDD+F+ I+ + + +D + RM + A + T++T A + S
Sbjct: 524 FVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQ 583
Query: 509 FRSVQCFCIYTGMTLLFCYFYNITCFGAFMAL 540
+V F ++ + + C+ + A + L
Sbjct: 584 IPAVHDFGLFMSLIVSCCWLAVLVTMPAALGL 615
>gi|195963316 PWWP domain containing 2A isoform b [Homo sapiens]
Length = 755
Score = 45.8 bits (107), Expect = 1e-04
Identities = 33/117 (28%), Positives = 48/117 (41%), Gaps = 16/117 (13%)
Query: 2 PWVEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPP-----KSPEP 56
P +EP P P A+ P + Q+S + +PP P PP +SPE
Sbjct: 25 PEMEPIPGSEAGTDPLPVTATEASVPDGETDGQQSAPQADEPPLPPPPPPPGELARSPEA 84
Query: 57 SGP----------LASEQDAPLPEGD-DAPPRPSMLDDAPRLPLELDDAPLPEEETP 102
GP +E A P+G + PP P+ + P P E ++ PLP+ P
Sbjct: 85 VGPELEAEEKLSVRVAESAAAAPQGGPELPPSPASPPEQPPAPEEREEPPLPQPVAP 141
>gi|153791982 PWWP domain containing 2A isoform a [Homo sapiens]
Length = 560
Score = 45.8 bits (107), Expect = 1e-04
Identities = 33/117 (28%), Positives = 48/117 (41%), Gaps = 16/117 (13%)
Query: 2 PWVEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPP-----KSPEP 56
P +EP P P A+ P + Q+S + +PP P PP +SPE
Sbjct: 25 PEMEPIPGSEAGTDPLPVTATEASVPDGETDGQQSAPQADEPPLPPPPPPPGELARSPEA 84
Query: 57 SGP----------LASEQDAPLPEGD-DAPPRPSMLDDAPRLPLELDDAPLPEEETP 102
GP +E A P+G + PP P+ + P P E ++ PLP+ P
Sbjct: 85 VGPELEAEEKLSVRVAESAAAAPQGGPELPPSPASPPEQPPAPEEREEPPLPQPVAP 141
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 45.8 bits (107), Expect = 1e-04
Identities = 34/103 (33%), Positives = 41/103 (39%), Gaps = 9/103 (8%)
Query: 6 PKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQD 65
P P+P P P +P + P + S PPP P A P P P P A
Sbjct: 1465 PTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAA---- 1520
Query: 66 APLPEGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEPTAIC 108
APL + P PS D P LP D PL + E A+C
Sbjct: 1521 APLAAPPEEPAAPSPED--PELP---DTRPLHLAKKQETAAVC 1558
Score = 35.8 bits (81), Expect = 0.15
Identities = 29/107 (27%), Positives = 36/107 (33%), Gaps = 14/107 (13%)
Query: 10 PGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGP---------- 59
PGP P L +S P+ E PPP P P+ P P P
Sbjct: 1431 PGPPPLPGLPSANSNGTPE---PPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPP 1487
Query: 60 -LASEQDAPLPEGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEPT 105
+A +P P PP P+M P P P EE P+
Sbjct: 1488 LVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPS 1534
Score = 32.3 bits (72), Expect = 1.7
Identities = 27/106 (25%), Positives = 35/106 (33%), Gaps = 5/106 (4%)
Query: 2 PWVEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLA 61
P PK P+ P L + GP + S G PP P P P
Sbjct: 1409 PLAGPKDTSTPDGPP-LAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTP 1467
Query: 62 SEQDAPLPEGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEPTAI 107
Q P P PP+P++ P + P P P P A+
Sbjct: 1468 QPQPPPPPP----PPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAM 1509
Score = 30.0 bits (66), Expect = 8.4
Identities = 25/78 (32%), Positives = 26/78 (33%), Gaps = 16/78 (20%)
Query: 43 PPPGPLAPPKSPEPSGPLASEQDAPLPEGDDAPP---RPSMLDDAPR------------- 86
PPP P A P P G L LP PP PS+L AP
Sbjct: 765 PPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLL 824
Query: 87 LPLELDDAPLPEEETPEP 104
P D AP P P P
Sbjct: 825 EPATRDGAPQPPPPPPPP 842
Score = 30.0 bits (66), Expect = 8.4
Identities = 25/95 (26%), Positives = 33/95 (34%), Gaps = 8/95 (8%)
Query: 16 PKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQ------DAPLP 69
P L P + P + + G P PG + + P PL E+ AP P
Sbjct: 1408 PPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTP 1467
Query: 70 EGDDAPPRPSMLDDAPRLPLELDDAPLPEEETPEP 104
+ PP P P P + AP P P P
Sbjct: 1468 QPQPPPPPPPPQPALPSPPPLV--APTPSSPPPPP 1500
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 44.7 bits (104), Expect = 3e-04
Identities = 39/126 (30%), Positives = 45/126 (35%), Gaps = 22/126 (17%)
Query: 2 PWVEPKPRPGPEQKPKLTK-----------PDSATGPQWYQESQESESEGKQPPPGPLAP 50
PW P P P P P L P+ A GP S+ + +P P P
Sbjct: 29 PWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESATELYTEPTPEPATE 88
Query: 51 PKS---PEPSGPLASEQDA-PLPEGDDAPPRPSMLDDAPRLPLELDDAPLPE-------E 99
P S PEP+ A E P PE P S + P LE P PE E
Sbjct: 89 PASEPAPEPATEPAPEPATEPAPEPAPEPATESAPEPTPEPALESVPEPAPELTPEVAPE 148
Query: 100 ETPEPT 105
PEPT
Sbjct: 149 LAPEPT 154
Score = 37.0 bits (84), Expect = 0.069
Identities = 27/83 (32%), Positives = 33/83 (39%), Gaps = 21/83 (25%)
Query: 38 SEGKQPPPGPLAPPKSPEPSGPLASEQDAPLPEGDDAPPRPSMLDDAPRLPL-----ELD 92
++G PP P +SPEP P P P PP P +L +A P+ EL
Sbjct: 8 AQGTAPPQDGEQPAESPEPPPPWPPPPPPPAP-----PPAPPLLSEASPEPIPEPCPELA 62
Query: 93 DAPLPE-----------EETPEP 104
P PE E TPEP
Sbjct: 63 PGPCPEATSESATELYTEPTPEP 85
Score = 35.4 bits (80), Expect = 0.20
Identities = 27/80 (33%), Positives = 33/80 (41%), Gaps = 10/80 (12%)
Query: 35 ESESEGKQPPPG--PLAPPKSPEPSGPLASEQD-----APLPEGDDAPPRPSMLDDAPRL 87
E +E +PPP P PP +P P+ PL SE P PE P + + A L
Sbjct: 18 EQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESATEL 77
Query: 88 PLELDDAPLPE---EETPEP 104
E P E E PEP
Sbjct: 78 YTEPTPEPATEPASEPAPEP 97
>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
sapiens]
Length = 1751
Score = 43.9 bits (102), Expect = 6e-04
Identities = 27/78 (34%), Positives = 30/78 (38%), Gaps = 5/78 (6%)
Query: 6 PKPRPGPEQKPKLTKPDSAT-----GPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPL 60
P PGP P + P + GP Q EG+Q PPGP PP P GP
Sbjct: 1355 PPGPPGPRGYPGIPGPKGESIRGQPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPH 1414
Query: 61 ASEQDAPLPEGDDAPPRP 78
P P G PP P
Sbjct: 1415 RQTISVPGPPGPPGPPGP 1432
Score = 32.7 bits (73), Expect = 1.3
Identities = 24/81 (29%), Positives = 30/81 (37%), Gaps = 9/81 (11%)
Query: 10 PGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQDA--- 66
PGP+ P D G E + +GK GP P +P GP + D
Sbjct: 801 PGPQGPPGPPGRDGTPGRDG--EPGDPGEDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVG 858
Query: 67 ----PLPEGDDAPPRPSMLDD 83
P P+G PP PS D
Sbjct: 859 ERGPPGPQGPPGPPGPSFRHD 879
>gi|110611233 alpha 1 type XVIII collagen isoform 2 precursor [Homo
sapiens]
Length = 1336
Score = 43.9 bits (102), Expect = 6e-04
Identities = 27/78 (34%), Positives = 30/78 (38%), Gaps = 5/78 (6%)
Query: 6 PKPRPGPEQKPKLTKPDSAT-----GPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPL 60
P PGP P + P + GP Q EG+Q PPGP PP P GP
Sbjct: 940 PPGPPGPRGYPGIPGPKGESIRGQPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPH 999
Query: 61 ASEQDAPLPEGDDAPPRP 78
P P G PP P
Sbjct: 1000 RQTISVPGPPGPPGPPGP 1017
Score = 32.7 bits (73), Expect = 1.3
Identities = 24/81 (29%), Positives = 30/81 (37%), Gaps = 9/81 (11%)
Query: 10 PGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQDA--- 66
PGP+ P D G E + +GK GP P +P GP + D
Sbjct: 386 PGPQGPPGPPGRDGTPGRDG--EPGDPGEDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVG 443
Query: 67 ----PLPEGDDAPPRPSMLDD 83
P P+G PP PS D
Sbjct: 444 ERGPPGPQGPPGPPGPSFRHD 464
>gi|110611235 alpha 1 type XVIII collagen isoform 1 precursor [Homo
sapiens]
Length = 1516
Score = 43.9 bits (102), Expect = 6e-04
Identities = 27/78 (34%), Positives = 30/78 (38%), Gaps = 5/78 (6%)
Query: 6 PKPRPGPEQKPKLTKPDSAT-----GPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPL 60
P PGP P + P + GP Q EG+Q PPGP PP P GP
Sbjct: 1120 PPGPPGPRGYPGIPGPKGESIRGQPGPPGPQGPPGIGYEGRQGPPGPPGPPGPPSFPGPH 1179
Query: 61 ASEQDAPLPEGDDAPPRP 78
P P G PP P
Sbjct: 1180 RQTISVPGPPGPPGPPGP 1197
Score = 32.7 bits (73), Expect = 1.3
Identities = 24/81 (29%), Positives = 30/81 (37%), Gaps = 9/81 (11%)
Query: 10 PGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQDA--- 66
PGP+ P D G E + +GK GP P +P GP + D
Sbjct: 566 PGPQGPPGPPGRDGTPGRDG--EPGDPGEDGKPGDTGPQGFPGTPGDVGPKGDKGDPGVG 623
Query: 67 ----PLPEGDDAPPRPSMLDD 83
P P+G PP PS D
Sbjct: 624 ERGPPGPQGPPGPPGPSFRHD 644
>gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
isoform 2 [Homo sapiens]
Length = 835
Score = 42.7 bits (99), Expect = 0.001
Identities = 33/157 (21%), Positives = 68/157 (43%), Gaps = 10/157 (6%)
Query: 394 IILFAVTSC-------FRFDCIR---NKMCVAAFGVISAFLAVVSGFGLLLHIGVPFVII 443
II+ +T C F+F +R +K + G+ + F + V ++ + +
Sbjct: 62 IIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGL 121
Query: 444 VANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVSITITTITNILALYT 503
PF +L + + + +N D++RE ++ + + T+ + L +
Sbjct: 122 NEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGV 181
Query: 504 GIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMAL 540
G MS R ++ C + M++L YF +T F A ++L
Sbjct: 182 GTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSL 218
>gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform
1 [Homo sapiens]
Length = 888
Score = 42.7 bits (99), Expect = 0.001
Identities = 33/157 (21%), Positives = 68/157 (43%), Gaps = 10/157 (6%)
Query: 394 IILFAVTSC-------FRFDCIR---NKMCVAAFGVISAFLAVVSGFGLLLHIGVPFVII 443
II+ +T C F+F +R +K + G+ + F + V ++ + +
Sbjct: 62 IIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGL 121
Query: 444 VANSPFLILGVGVDDMFIMISAWHKTNLADDIRERMSNVYSKAAVSITITTITNILALYT 503
PF +L + + + +N D++RE ++ + + T+ + L +
Sbjct: 122 NEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGV 181
Query: 504 GIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMAL 540
G MS R ++ C + M++L YF +T F A ++L
Sbjct: 182 GTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSL 218
>gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]
Length = 1838
Score = 42.0 bits (97), Expect = 0.002
Identities = 35/110 (31%), Positives = 41/110 (37%), Gaps = 16/110 (14%)
Query: 6 PKPRPGPEQKPKLTKPDSATGPQWYQESQESESE-------GKQPPPGPLAPPKSPEPSG 58
P PGP P P GP+ Q + ++ E GK P GP P P P G
Sbjct: 1379 PTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDG 1438
Query: 59 -----PLASEQDAPLPEGDDAPPRPSMLDDAPRLP-LELDDAPLPEEETP 102
EQ P G D PP P P LP L+ D P E+ P
Sbjct: 1439 LRGIPGPVGEQGLPGSPGPDGPPGPM---GPPGLPGLKGDSGPKGEKGHP 1485
Score = 38.1 bits (87), Expect = 0.031
Identities = 30/91 (32%), Positives = 34/91 (37%), Gaps = 9/91 (9%)
Query: 4 VEPKPRPGPEQKPKLTKPDSATGPQWYQ-ESQESESEGKQPPPGPLAPPKSPEPS---GP 59
V K PG +P L GP+ + E ES G PPGP PP P GP
Sbjct: 1281 VGEKGEPGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKGSPGP 1340
Query: 60 LASEQD-----APLPEGDDAPPRPSMLDDAP 85
+ D P P G D PP D P
Sbjct: 1341 VGFPGDPGPPGEPGPAGQDGPPGDKGDDGEP 1371
Score = 34.3 bits (77), Expect = 0.45
Identities = 24/80 (30%), Positives = 29/80 (36%), Gaps = 7/80 (8%)
Query: 6 PKPRPGPEQKPKLTKPDSATGPQWYQESQ-------ESESEGKQPPPGPLAPPKSPEPSG 58
PK PGP P +T D GP+ Q + + G Q PGP P G
Sbjct: 686 PKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPGPPGQQGNPGAQGLPGPQGAIGPPGEKG 745
Query: 59 PLASEQDAPLPEGDDAPPRP 78
PL +P D P P
Sbjct: 746 PLGKPGLPGMPGADGPPGHP 765
Score = 32.3 bits (72), Expect = 1.7
Identities = 20/56 (35%), Positives = 23/56 (41%), Gaps = 1/56 (1%)
Query: 4 VEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESE-GKQPPPGPLAPPKSPEPSG 58
+ P GP KP L A GP + + E G Q PPGP P P P G
Sbjct: 738 IGPPGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRG 793
Score = 32.3 bits (72), Expect = 1.7
Identities = 35/154 (22%), Positives = 45/154 (29%), Gaps = 47/154 (30%)
Query: 6 PKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQD 65
P+ GP+ + +T P GP G PPGP S P+GP E
Sbjct: 1508 PQGSSGPKGEQGITGPSGPIGPPG--------PPGLPGPPGPKGAKGSSGPTGP-KGEAG 1558
Query: 66 APLPEGDDAPP-------------------RPSMLDDAP-------------------RL 87
P P G PP +LDD L
Sbjct: 1559 HPGPPGPPGPPGEVIQPLPIQASRTRRNIDASQLLDDGNGENYVDYADGMEEIFGSLNSL 1618
Query: 88 PLELDDAPLPEEETPEPTAICRHRHRCHTDCLEG 121
LE++ P P C+ CH D +G
Sbjct: 1619 KLEIEQMKRPLGTQQNPARTCKDLQLCHPDFPDG 1652
Score = 32.0 bits (71), Expect = 2.2
Identities = 17/49 (34%), Positives = 22/49 (44%), Gaps = 2/49 (4%)
Query: 39 EGKQPPPGPLAPPKSPEPSGPLASEQDAPLP--EGDDAPPRPSMLDDAP 85
+G + PPGP P SP GP + +P G PP P+ AP
Sbjct: 1074 KGNEGPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGAP 1122
Score = 31.2 bits (69), Expect = 3.8
Identities = 22/77 (28%), Positives = 30/77 (38%), Gaps = 3/77 (3%)
Query: 9 RPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQDAPL 68
+PGP + T P GP+ + + +G GP PP P+GP P
Sbjct: 905 KPGPRGQRGPTGPRGERGPRGI--TGKPGPKGNSGGDGPAGPPGERGPNGP-QGPTGFPG 961
Query: 69 PEGDDAPPRPSMLDDAP 85
P+G PP L P
Sbjct: 962 PKGPPGPPGKDGLPGHP 978
Score = 30.4 bits (67), Expect = 6.5
Identities = 21/68 (30%), Positives = 23/68 (33%), Gaps = 10/68 (14%)
Query: 6 PKPRPGPEQKPKLTKPDSATGPQWYQ----------ESQESESEGKQPPPGPLAPPKSPE 55
PK PGP P P GP E ++ S G PGP PP
Sbjct: 1334 PKGSPGPVGFPGDPGPPGEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRG 1393
Query: 56 PSGPLASE 63
P GP E
Sbjct: 1394 PPGPAGPE 1401
Score = 30.0 bits (66), Expect = 8.4
Identities = 27/88 (30%), Positives = 31/88 (35%), Gaps = 8/88 (9%)
Query: 11 GPEQKPKLTKPDSATG-PQWYQESQESESEGKQPPPGPLAPPKSPEPSGPLASEQDAPLP 69
GP+ P PD G P E S G PPGP+ PP P G P
Sbjct: 1426 GPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSG-------P 1478
Query: 70 EGDDAPPRPSMLDDAPRLPLELDDAPLP 97
+G+ P L P E D LP
Sbjct: 1479 KGEKGHPGLIGLIGPPGEQGEKGDRGLP 1506
Score = 30.0 bits (66), Expect = 8.4
Identities = 23/77 (29%), Positives = 30/77 (38%), Gaps = 7/77 (9%)
Query: 4 VEPKPRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKSPEPSGPL-AS 62
+ P G + L P ++GP+ E G P GP PP P P GP A
Sbjct: 1491 IGPPGEQGEKGDRGLPGPQGSSGPKG-----EQGITGPSGPIGPPGPPGLPGPPGPKGAK 1545
Query: 63 EQDAPL-PEGDDAPPRP 78
P P+G+ P P
Sbjct: 1546 GSSGPTGPKGEAGHPGP 1562
>gi|154816198 transcription elongation factor B polypeptide 3C-like
[Homo sapiens]
Length = 546
Score = 42.0 bits (97), Expect = 0.002
Identities = 36/122 (29%), Positives = 47/122 (38%), Gaps = 16/122 (13%)
Query: 21 PDSATGPQWYQESQESESEGKQPPPGPLAP-PKSPEPSGPLASEQDAPLPEGDDAPPRPS 79
P++AT P+ S E ++ PPG P P+SP P + PR +
Sbjct: 113 PENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSPSRE-----------PRAERKRPRMA 161
Query: 80 MLDDAPRLPLELDDAPLPEEETPEPTAICRHRHRCHTDCLEG--LLSRTFQW--LGWQVG 135
D P APLP E PEP R H +G LL + Q G VG
Sbjct: 162 PADSGPHRDPPTRTAPLPMPEGPEPAVPGEQPGRGHAHAAQGGPLLGQGCQGQPQGEAVG 221
Query: 136 AH 137
+H
Sbjct: 222 SH 223
>gi|156938279 transcription elongation factor B polypeptide 3C [Homo
sapiens]
Length = 546
Score = 42.0 bits (97), Expect = 0.002
Identities = 36/122 (29%), Positives = 47/122 (38%), Gaps = 16/122 (13%)
Query: 21 PDSATGPQWYQESQESESEGKQPPPGPLAP-PKSPEPSGPLASEQDAPLPEGDDAPPRPS 79
P++AT P+ S E ++ PPG P P+SP P + PR +
Sbjct: 113 PENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSPSRE-----------PRAERKRPRMA 161
Query: 80 MLDDAPRLPLELDDAPLPEEETPEPTAICRHRHRCHTDCLEG--LLSRTFQW--LGWQVG 135
D P APLP E PEP R H +G LL + Q G VG
Sbjct: 162 PADSGPHRDPPTRTAPLPMPEGPEPAVPGEQPGRGHAHAAQGGPLLGQGCQGQPQGEAVG 221
Query: 136 AH 137
+H
Sbjct: 222 SH 223
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 41.6 bits (96), Expect = 0.003
Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 1/67 (1%)
Query: 8 PRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKS-PEPSGPLASEQDA 66
P P E +P L TG +Q + + PPP P++PP + SGPL S+ D
Sbjct: 1165 PSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDT 1224
Query: 67 PLPEGDD 73
PE ++
Sbjct: 1225 DAPEEEE 1231
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 41.6 bits (96), Expect = 0.003
Identities = 22/67 (32%), Positives = 32/67 (47%), Gaps = 1/67 (1%)
Query: 8 PRPGPEQKPKLTKPDSATGPQWYQESQESESEGKQPPPGPLAPPKS-PEPSGPLASEQDA 66
P P E +P L TG +Q + + PPP P++PP + SGPL S+ D
Sbjct: 1220 PSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDT 1279
Query: 67 PLPEGDD 73
PE ++
Sbjct: 1280 DAPEEEE 1286
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,687,852
Number of Sequences: 37866
Number of extensions: 1704490
Number of successful extensions: 16215
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 653
Number of HSP's that attempted gapping in prelim test: 11015
Number of HSP's gapped (non-prelim): 4367
length of query: 767
length of database: 18,247,518
effective HSP length: 110
effective length of query: 657
effective length of database: 14,082,258
effective search space: 9252043506
effective search space used: 9252043506
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.