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Search of human proteins with 193290160
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|193290160 CTAGE family, member 4 [Homo sapiens]
(777 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193290160 CTAGE family, member 4 [Homo sapiens] 1560 0.0
gi|224586773 hypothetical protein LOC643854 [Homo sapiens] 1543 0.0
gi|56847634 hypothetical protein LOC441294 [Homo sapiens] 1504 0.0
gi|146262005 CTAGE family, member 6 [Homo sapiens] 1500 0.0
gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens] 1293 0.0
gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens] 1254 0.0
gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens] 1241 0.0
gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens] 1202 0.0
gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isofo... 1131 0.0
gi|122891870 melanoma inhibitory activity family, member 3 [Homo... 239 5e-63
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 80 7e-15
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 79 1e-14
gi|55770834 centromere protein F [Homo sapiens] 78 3e-14
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 78 4e-14
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 76 1e-13
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 76 1e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 74 7e-13
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 73 9e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 72 2e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 72 2e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 72 2e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 72 2e-12
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 72 3e-12
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 72 3e-12
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 72 3e-12
gi|118498356 kinectin 1 isoform a [Homo sapiens] 71 3e-12
gi|33620775 kinectin 1 isoform a [Homo sapiens] 71 3e-12
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 71 3e-12
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 71 3e-12
gi|42794779 myosin 18A isoform b [Homo sapiens] 71 4e-12
>gi|193290160 CTAGE family, member 4 [Homo sapiens]
Length = 777
Score = 1560 bits (4039), Expect = 0.0
Identities = 777/777 (100%), Positives = 777/777 (100%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW
Sbjct: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA
Sbjct: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE
Sbjct: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE
Sbjct: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ
Sbjct: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ
Sbjct: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE
Sbjct: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
Query: 421 EKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR
Sbjct: 421 EKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ 540
KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ
Sbjct: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ 540
Query: 541 TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP 600
TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP
Sbjct: 541 TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP 600
Query: 601 VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE 660
VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE
Sbjct: 601 VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE 660
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP 720
MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP
Sbjct: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP 720
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF 777
FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF
Sbjct: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF 777
>gi|224586773 hypothetical protein LOC643854 [Homo sapiens]
Length = 777
Score = 1543 bits (3994), Expect = 0.0
Identities = 769/777 (98%), Positives = 772/777 (99%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPGATPQPYLGLVLEEL RVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW
Sbjct: 1 MEEPGATPQPYLGLVLEELGRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA
Sbjct: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
AAEEARSLEATCEKL+RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE
Sbjct: 121 AAEEARSLEATCEKLSRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG+VSE
Sbjct: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLEL+VNSQ
Sbjct: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELKVNSQ 300
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
WENGANLDDP KGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ
Sbjct: 301 WENGANLDDPPKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE
Sbjct: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
Query: 421 EKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EKIS ATE LETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR
Sbjct: 421 EKISHATEELETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ 540
KENAHNKQKLTE ELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ
Sbjct: 481 KENAHNKQKLTERELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ 540
Query: 541 TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP 600
TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP
Sbjct: 541 TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP 600
Query: 601 VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE 660
VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE
Sbjct: 601 VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE 660
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP 720
MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP
Sbjct: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP 720
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF 777
FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF
Sbjct: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF 777
>gi|56847634 hypothetical protein LOC441294 [Homo sapiens]
Length = 777
Score = 1504 bits (3893), Expect = 0.0
Identities = 751/777 (96%), Positives = 758/777 (97%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW
Sbjct: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA
Sbjct: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE
Sbjct: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG+VSE
Sbjct: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGQVSE 240
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ
Sbjct: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ
Sbjct: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE
Sbjct: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
Query: 421 EKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EK+SRATE LETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR
Sbjct: 421 EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ 540
KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREH+P P+PLG+ SSETRAF SPQ
Sbjct: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ 540
Query: 541 TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP 600
TLLEDPL LSPVLP GGGRGP PGNPLDHQITNERGEPS DRL DPHRAPSDTGSLSSP
Sbjct: 541 TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP 600
Query: 601 VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE 660
VEQD +MMFPPPGQSYPDS LPPQREDRFYSNSERLSG AEPRSFKMTSLDKMD SMPSE
Sbjct: 601 VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE 660
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP 720
MESSRNDAKDDLGNLNVPDSSLPAENEATGPG IPPPLAP+ GPLFPVDTRGPFMRRGPP
Sbjct: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP 720
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF 777
FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPY HPRPGFYPNP F
Sbjct: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF 777
>gi|146262005 CTAGE family, member 6 [Homo sapiens]
Length = 777
Score = 1500 bits (3883), Expect = 0.0
Identities = 749/777 (96%), Positives = 757/777 (97%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW
Sbjct: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA
Sbjct: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE
Sbjct: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE
Sbjct: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ
Sbjct: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ
Sbjct: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
TQQ SLQSENIYFESENQKLQQKLKIMTEFYQE+EMKLYRKLTVEENYRIEEEEKLS+VE
Sbjct: 361 TQQESLQSENIYFESENQKLQQKLKIMTEFYQEDEMKLYRKLTVEENYRIEEEEKLSKVE 420
Query: 421 EKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EK+SRATE LETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR
Sbjct: 421 EKLSRATEQLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ 540
KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREH+P P+PLG+ SSETRAF SPQ
Sbjct: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHAPNGPAPLGQRSSETRAFLSPQ 540
Query: 541 TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP 600
TLLEDPL LSPVLP GGGRGP PGNPLDHQITNERGEPS DRL DPHRAPSDTGSLSSP
Sbjct: 541 TLLEDPLGLSPVLPEGGGRGPRGPGNPLDHQITNERGEPSCDRLTDPHRAPSDTGSLSSP 600
Query: 601 VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE 660
VEQD +MMFPPPGQSYPDS LPPQREDRFYSNSERLSG AEPRSFKMTSLDKMD SMPSE
Sbjct: 601 VEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSGSAEPRSFKMTSLDKMDGSMPSE 660
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP 720
MESSRNDAKDDLGNLNVPDSSLPAENEATGPG IPPPLAP+ GPLFPVDTRGPFMRRGPP
Sbjct: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRGPLFPVDTRGPFMRRGPP 720
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNPTF 777
FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPY HPRPGFYPNP F
Sbjct: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYFHPRPGFYPNPAF 777
>gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens]
Length = 804
Score = 1293 bits (3346), Expect = 0.0
Identities = 651/775 (84%), Positives = 694/775 (89%), Gaps = 2/775 (0%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPG TPQPYLGL+LEELRRVVAALPE MRPD N YGFP ELV+CAAV+GFF VL FLW
Sbjct: 1 MEEPGVTPQPYLGLLLEELRRVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGRE+KL LSGLIEEK KLLEKFSL+QKEYEGYEVESSL+DASFEK
Sbjct: 61 RSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKE 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
A E A+SLEATCEKLNRSNSELEDEILCLEK+LKEEKSKHS+QDELMADISK IQSLEDE
Sbjct: 121 ATE-AQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDE 179
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
SKSLKSQ+AEAK+ K F+M+EER IAIKDALNENSQLQ S KQL Q EAEVWK +VSE
Sbjct: 180 SKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQ-EAEVWKEQVSE 238
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQK+TFEDSKVHAEQVLNDKE+HIKTLT L MKD AA+L ED TDDDNLELE+NS+
Sbjct: 239 LNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSE 298
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
ENGA LD+P KGALKKLIHAAKLN SLK+LEGERN I IQLSEVDKTKEELTEHIKNLQ
Sbjct: 299 SENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQ 358
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
T+QASLQSEN +FE+ENQKLQQKLK+MTE YQENEMKL+RKLTVEENYR+E+EEKLS+V+
Sbjct: 359 TEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVD 418
Query: 421 EKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EKIS ATE LETYRK AKDLEEELERT+H YQ Q+IS+EK+ HDNWLAAR AERNL+DLR
Sbjct: 419 EKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLR 478
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ 540
KENAHN+QKLTETELKFELLEKDP ALDV NTAFGREHSP PSPLG PSSETRAF SP
Sbjct: 479 KENAHNRQKLTETELKFELLEKDPYALDVPNTAFGREHSPYGPSPLGWPSSETRAFLSPP 538
Query: 541 TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP 600
TLLE PLRLSP+LPGGGGRG PGNPLDHQITNERGE S DRL DPHRAPSDTGSLS P
Sbjct: 539 TLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPP 598
Query: 601 VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE 660
+QDRRMMFPPPGQSYPDS LPPQR+DRF SNS RLSGPAE RSF M SLDKMD SMPSE
Sbjct: 599 WDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSE 658
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP 720
MESSRND KDDLGNLNVPDSSLPAENEATGPG +PPPLAPI GPLFPVD RGPF+RRGPP
Sbjct: 659 MESSRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPP 718
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNP 775
FPPPPPG MFGASR YFPP DFPGPP APFAMRN+YPPRG PPYL PRPGF+P P
Sbjct: 719 FPPPPPGAMFGASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPP 773
>gi|42740905 CTAGE family, member 5 isoform 2 [Homo sapiens]
Length = 792
Score = 1254 bits (3244), Expect = 0.0
Identities = 632/754 (83%), Positives = 674/754 (89%), Gaps = 2/754 (0%)
Query: 22 VVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGAT 81
VVAALPE MRPD N YGFP ELV+CAAV+GFF VL FLWRSFRSVRSRLYVGRE+KL
Sbjct: 10 VVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALM 69
Query: 82 LSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSE 141
LSGLIEEK KLLEKFSL+QKEYEGYEVESSL+DASFEK A E A+SLEATCEKLNRSNSE
Sbjct: 70 LSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATE-AQSLEATCEKLNRSNSE 128
Query: 142 LEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMS 201
LEDEILCLEK+LKEEKSKHS+QDELMADISK IQSLEDESKSLKSQ+AEAK+ K F+M+
Sbjct: 129 LEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMN 188
Query: 202 EERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLND 261
EER IAIKDALNENSQLQ S KQL Q EAEVWK +VSELNKQK+TFEDSKVHAEQVLND
Sbjct: 189 EERLKIAIKDALNENSQLQESQKQLLQ-EAEVWKEQVSELNKQKVTFEDSKVHAEQVLND 247
Query: 262 KENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHA 321
KE+HIKTLT L MKD AA+L ED TDDDNLELE+NS+ ENGA LD+P KGALKKLIHA
Sbjct: 248 KESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHA 307
Query: 322 AKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQ 381
AKLN SLK+LEGERN I IQLSEVDKTKEELTEHIKNLQT+QASLQSEN +FE+ENQKLQ
Sbjct: 308 AKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQ 367
Query: 382 QKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLE 441
QKLK+MTE YQENEMKL+RKLTVEENYR+E+EEKLS+V+EKIS ATE LETYRK AKDLE
Sbjct: 368 QKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLE 427
Query: 442 EELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLE 501
EELERT+H YQ Q+IS+EK+ HDNWLAAR AERNL+DLRKENAHN+QKLTETELKFELLE
Sbjct: 428 EELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLE 487
Query: 502 KDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRGP 561
KDP ALDV NTAFGREHSP PSPLG PSSETRAF SP TLLE PLRLSP+LPGGGGRG
Sbjct: 488 KDPYALDVPNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGS 547
Query: 562 SSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTL 621
PGNPLDHQITNERGE S DRL DPHRAPSDTGSLS P +QDRRMMFPPPGQSYPDS L
Sbjct: 548 RGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSAL 607
Query: 622 PPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSS 681
PPQR+DRF SNS RLSGPAE RSF M SLDKMD SMPSEMESSRND KDDLGNLNVPDSS
Sbjct: 608 PPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSS 667
Query: 682 LPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRD 741
LPAENEATGPG +PPPLAPI GPLFPVD RGPF+RRGPPFPPPPPG MFGASR YFPP D
Sbjct: 668 LPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGD 727
Query: 742 FPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNP 775
FPGPP APFAMRN+YPPRG PPYL PRPGF+P P
Sbjct: 728 FPGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPP 761
>gi|42740901 CTAGE family, member 5 isoform 4 [Homo sapiens]
Length = 775
Score = 1241 bits (3212), Expect = 0.0
Identities = 625/746 (83%), Positives = 667/746 (89%), Gaps = 2/746 (0%)
Query: 30 MRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEK 89
MRPD N YGFP ELV+CAAV+GFF VL FLWRSFRSVRSRLYVGRE+KL LSGLIEEK
Sbjct: 1 MRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEK 60
Query: 90 CKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCL 149
KLLEKFSL+QKEYEGYEVESSL+DASFEK A E A+SLEATCEKLNRSNSELEDEILCL
Sbjct: 61 SKLLEKFSLVQKEYEGYEVESSLKDASFEKEATE-AQSLEATCEKLNRSNSELEDEILCL 119
Query: 150 EKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAI 209
EK+LKEEKSKHS+QDELMADISK IQSLEDESKSLKSQ+AEAK+ K F+M+EER IAI
Sbjct: 120 EKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAI 179
Query: 210 KDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTL 269
KDALNENSQLQ S KQL Q EAEVWK +VSELNKQK+TFEDSKVHAEQVLNDKE+HIKTL
Sbjct: 180 KDALNENSQLQESQKQLLQ-EAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTL 238
Query: 270 TGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLK 329
T L MKD AA+L ED TDDDNLELE+NS+ ENGA LD+P KGALKKLIHAAKLN SLK
Sbjct: 239 TERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLK 298
Query: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
+LEGERN I IQLSEVDKTKEELTEHIKNLQT+QASLQSEN +FE+ENQKLQQKLK+MTE
Sbjct: 299 TLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTE 358
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVH 449
YQENEMKL+RKLTVEENYR+E+EEKLS+V+EKIS ATE LETYRK AKDLEEELERT+H
Sbjct: 359 LYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIH 418
Query: 450 FYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDV 509
YQ Q+IS+EK+ HDNWLAAR AERNL+DLRKENAHN+QKLTETELKFELLEKDP ALDV
Sbjct: 419 SYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDV 478
Query: 510 SNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRGPSSPGNPLD 569
NTAFGREHSP PSPLG PSSETRAF SP TLLE PLRLSP+LPGGGGRG PGNPLD
Sbjct: 479 PNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLD 538
Query: 570 HQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTLPPQREDRF 629
HQITNERGE S DRL DPHRAPSDTGSLS P +QDRRMMFPPPGQSYPDS LPPQR+DRF
Sbjct: 539 HQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRF 598
Query: 630 YSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEAT 689
SNS RLSGPAE RSF M SLDKMD SMPSEMESSRND KDDLGNLNVPDSSLPAENEAT
Sbjct: 599 CSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEAT 658
Query: 690 GPGLIPPPLAPISGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAP 749
GPG +PPPLAPI GPLFPVD RGPF+RRGPPFPPPPPG MFGASR YFPP DFPGPP AP
Sbjct: 659 GPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAP 718
Query: 750 FAMRNIYPPRGLPPYLHPRPGFYPNP 775
FAMRN+YPPRG PPYL PRPGF+P P
Sbjct: 719 FAMRNVYPPRGFPPYLPPRPGFFPPP 744
>gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens]
Length = 761
Score = 1202 bits (3111), Expect = 0.0
Identities = 617/775 (79%), Positives = 659/775 (85%), Gaps = 45/775 (5%)
Query: 1 MEEPGATPQPYLGLVLEELRRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLW 60
MEEPG TPQPYLGL+LEELRRVVAALPE MRPD N YGFP ELV+CAAV+GFF VL FLW
Sbjct: 1 MEEPGVTPQPYLGLLLEELRRVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLW 60
Query: 61 RSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA 120
RSFRSVRSRLYVGRE+KL LSGLIEEK KLLEKFSL+QKEYEGYEVESSL+DASFEK
Sbjct: 61 RSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKE 120
Query: 121 AAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
A E A+SLEATCEKLNRSNSELEDEILCLEK+LKEEKSKHS+QDELMADISK IQSLEDE
Sbjct: 121 ATE-AQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDE 179
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
SKSLKSQ+AEAK+ K F+M+EER IAIKDALNENSQLQ S KQL Q EAEVWK +VSE
Sbjct: 180 SKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQ-EAEVWKEQVSE 238
Query: 241 LNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
LNKQK+TFEDSKVHAEQVLNDKE+HIKTLT L MKD AA+L ED TDDDNLELE+NS+
Sbjct: 239 LNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSE 298
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
ENGA LD+P KGALKKLIHAAKLN SLK+LEGERN I IQLSEVDKTKEELTEHIKNLQ
Sbjct: 299 SENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQ 358
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
T+QASLQSEN +FE+ENQKLQQKLK+MTE YQENEMKL+RKLTVEENYR+E+EEKLS+V+
Sbjct: 359 TEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVD 418
Query: 421 EKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLR 480
EKIS ATE LETYRK AKDLEEELERT+H YQ Q+IS+EK+ HDNWLAAR AERNL+DLR
Sbjct: 419 EKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLR 478
Query: 481 KENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQ 540
KENAHN+QKLTETELKFELLEKDP ALDV NTAFGR
Sbjct: 479 KENAHNRQKLTETELKFELLEKDPYALDVPNTAFGR------------------------ 514
Query: 541 TLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSP 600
G RG PGNPLDHQITNERGE S DRL DPHRAPSDTGSLS P
Sbjct: 515 ----------------GSRG---PGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPP 555
Query: 601 VEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSE 660
+QDRRMMFPPPGQSYPDS LPPQR+DRF SNS RLSGPAE RSF M SLDKMD SMPSE
Sbjct: 556 WDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSE 615
Query: 661 MESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPP 720
MESSRND KDDLGNLNVPDSSLPAENEATGPG +PPPLAPI GPLFPVD RGPF+RRGPP
Sbjct: 616 MESSRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPP 675
Query: 721 FPPPPPGTMFGASRGYFPPRDFPGPPHAPFAMRNIYPPRGLPPYLHPRPGFYPNP 775
FPPPPPG MFGASR YFPP DFPGPP APFAMRN+YPPRG PPYL PRPGF+P P
Sbjct: 676 FPPPPPGAMFGASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPP 730
>gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isoform
1 [Homo sapiens]
Length = 745
Score = 1131 bits (2925), Expect = 0.0
Identities = 583/749 (77%), Positives = 633/749 (84%), Gaps = 5/749 (0%)
Query: 30 MRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEK 89
MRPD +PYGFP ELV+ AAV GFF VL FLWRSFRSV SRLYV RE+K LSGLIEEK
Sbjct: 1 MRPDSHPYGFPWELVIRAAVAGFFAVL-FLWRSFRSVTSRLYVRREKKFAVALSGLIEEK 59
Query: 90 CKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCL 149
CKLLEKFSL+QKEYEGYEVESSL++ASFEK A E A+SLEATCEKLNR NSEL EILCL
Sbjct: 60 CKLLEKFSLVQKEYEGYEVESSLKNASFEKEATE-AQSLEATCEKLNRFNSELVHEILCL 118
Query: 150 EKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAI 209
EK+LKEEKSKHS+Q+ELMADISK IQSLEDESKSLKSQ+AEAK+ K F+ +EER I I
Sbjct: 119 EKELKEEKSKHSEQNELMADISKRIQSLEDESKSLKSQVAEAKMTFKRFQANEERLEIEI 178
Query: 210 KDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTL 269
+DA ENS+LQ S KQL Q EAEVWK +VSEL KQK TFEDSKVHAEQVLNDKENHIKTL
Sbjct: 179 QDAWKENSELQESQKQLLQ-EAEVWKEQVSELIKQKRTFEDSKVHAEQVLNDKENHIKTL 237
Query: 270 TGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLK 329
T L MKD A+LEED TDDDNLELE+NS+ E+GA LD+P KGALKKLIHAAKLN SLK
Sbjct: 238 TERLLKMKDGVAMLEEDVTDDDNLELEMNSESEDGAYLDNPPKGALKKLIHAAKLNASLK 297
Query: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
+LEGERN I IQLSEVDKTKEELTEHIKNLQT+QASLQSEN +FESENQKLQQKLK+MTE
Sbjct: 298 TLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFESENQKLQQKLKVMTE 357
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVH 449
YQENEMKLYRKL VEE R+E+EEKLS+V+E IS ATE LETYRK AKDL+E E+T+H
Sbjct: 358 LYQENEMKLYRKLIVEEKCRLEKEEKLSKVDEMISHATEELETYRKRAKDLKE-FEKTIH 416
Query: 450 FYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDV 509
FYQK++I +EK+ HDNW AA TAERNL+DLRKENAHN+QKLTE E K +LLEKDP LDV
Sbjct: 417 FYQKKIILHEKKAHDNWSAAWTAERNLNDLRKENAHNRQKLTEIEFKIKLLEKDPYGLDV 476
Query: 510 SNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRGPSSPGNPLD 569
NTAFGR+HSP PSPLG PSSETRA P TLLE PLRLSP+LP GGGRG PGNP D
Sbjct: 477 PNTAFGRQHSPYGPSPLGWPSSETRASLYPPTLLEGPLRLSPLLPRGGGRGSRGPGNPPD 536
Query: 570 HQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTLPPQREDRF 629
HQIT ERGE S DRL DPHRAPSD G L+ P EQD RMMFPPPGQSYPDS LPPQR+DRF
Sbjct: 537 HQITKERGESSCDRLTDPHRAPSDAGPLAPPWEQDYRMMFPPPGQSYPDSALPPQRQDRF 596
Query: 630 YSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEAT 689
YSN RLSGPAE RSF M SLDKMD SMPSEMESSRND KD+LGNL VPDSSLPAENEAT
Sbjct: 597 YSNCARLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDNLGNLKVPDSSLPAENEAT 656
Query: 690 GPGLIPPPLAPISGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFPPRDFPGPPHAP 749
GPG +PPPLAPI G LFPVDTRGPF+RRGPPFPPPPPGT+FGAS YF PRD PGPP AP
Sbjct: 657 GPGFVPPPLAPIRGLLFPVDTRGPFIRRGPPFPPPPPGTVFGASPDYFSPRDVPGPPRAP 716
Query: 750 FAMRNIYPPRGLPPYLHPRPGFY-PNPTF 777
FAMRN+Y PRG PY PRP F+ P PTF
Sbjct: 717 FAMRNVYLPRGFLPYRPPRPAFFPPAPTF 745
>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
sapiens]
Length = 1907
Score = 239 bits (611), Expect = 5e-63
Identities = 203/760 (26%), Positives = 361/760 (47%), Gaps = 86/760 (11%)
Query: 20 RRVVAALPESMRPDENPYGFPSELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLG 79
+ +VA LP+ ++P + YG P + V A +G +FLWR+ V+ R+Y EQ++
Sbjct: 1158 KSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRTVLVVKDRVYQVTEQQIS 1217
Query: 80 ATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAA-AEEARSLEATCEKLNRS 138
L +++E +L++K S +++ + E + +++ + ++EA + + L ++
Sbjct: 1218 EKLKTIMKENTELVQKLSNYEQKIK--ESKKHVQETRKQNMILSDEAIKYKDKIKTLEKN 1275
Query: 139 NSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
L+D L L+ E+ ++ + +L+++ KSI+ L+D S+ +E +I
Sbjct: 1276 QEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISMNASEFSEVQIALNEA 1335
Query: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQV 258
K+SEE+ EN++L+ +QL QQE E W +EL++Q +FE S+ E
Sbjct: 1336 KLSEEKVKSECHRVQEENARLKKKKEQL-QQEIEDWSKLHAELSEQIKSFEKSQKDLEVA 1394
Query: 259 LNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKL 318
L K+++I LT + + E + + + + + E G + ++ +K +K++
Sbjct: 1395 LTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQM 1454
Query: 319 IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQ 378
+ ++ ++ +E + + ++L TK L + +K L+ + SLQ+ E E +
Sbjct: 1455 MDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRNSLQAAKAGLEDECK 1514
Query: 379 KLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAK 438
L+QK++I+ E YQ+ EM L +KL+ EE R E E +LS +EK A E ++TY++ +
Sbjct: 1515 TLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIE 1574
Query: 439 DLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFE 498
++E+EL++T ++ Q+ ++EK+ H+NWL AR AER +++ ++E A+ + KL E K
Sbjct: 1575 EMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMA 1634
Query: 499 LLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGG 558
+L+++P + P P G+P+++ +P R P L G
Sbjct: 1635 MLQEEPVIV--------------KPMP-GKPNTQ------------NPPRRGP-LSQNGS 1666
Query: 559 RGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPD 618
GPS GE S ++P P LS+ + +RR M P D
Sbjct: 1667 FGPSPVSG----------GECSPPLTVEPPVRP-----LSATL--NRRDM-PRSEFGSVD 1708
Query: 619 STLPPQREDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVP 678
LP R+ + + P++P S T ++ R SS D+ G +N+
Sbjct: 1709 GPLP---HPRWSAEASGKPSPSDPGSGTATMMNSSSRG------SSPTRVLDE-GKVNMA 1758
Query: 679 DSSLPAENEATGPGLIPPPLAPISGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGYFP 738
P PG +P P+ GP+ P GP + PF P P P
Sbjct: 1759 PKGPPPF-----PG-VPLMSTPMGGPVPPPIRYGPPPQLCGPFGPRP-----------LP 1801
Query: 739 PRDFPGPPHAPFAMRNIYPPRGLPP-----YLHPRPGFYP 773
P PG P +R P G+PP LHPR GF P
Sbjct: 1802 PPFGPG-MRPPLGLREFAP--GVPPGRRDLPLHPR-GFLP 1837
Score = 30.4 bits (67), Expect = 6.6
Identities = 39/163 (23%), Positives = 66/163 (40%), Gaps = 24/163 (14%)
Query: 314 ALKKLIHAAKLNVSL-KSLEGERNHIIIQLSEVDKTKEELTE----------HIKNLQTQ 362
A++K + + N L K E E + E D E TE H + +Q
Sbjct: 157 AVEKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQ 216
Query: 363 QASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEEN----YRIEEEEKLSR 418
Q E FES + LQ KLK+ + N+ +++ E++ Y++ ++E
Sbjct: 217 ANHAQGEQASFESFEEMLQDKLKVPES--ENNKTSNSSQVSNEQDKIDAYKLLKKEMTLD 274
Query: 419 VEEKISRATEGL----ETYR---KLAKDLEEELERTVHFYQKQ 454
++ K + L ET R L D +EEL+ + K+
Sbjct: 275 LKTKFGSTADALVSDDETTRLVTSLEDDFDEELDTEYYAVGKE 317
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 80.1 bits (196), Expect = 7e-15
Identities = 88/395 (22%), Positives = 178/395 (45%), Gaps = 44/395 (11%)
Query: 74 REQKL---GATLSGLIEEKCKLLEKFSLIQKEYEGYEV--ESSLEDASFEKAAAEEARSL 128
+EQK+ T++ L E + +L ++ +QK + E+ + + + A+ R +
Sbjct: 1110 KEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLM 1169
Query: 129 EATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQI 188
+ +KL N+++ED LE+++K +K K E + + S+Q E+++ +K +
Sbjct: 1170 KELNQKLTNKNNKIED----LEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLL 1225
Query: 189 AEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHK---QLFQQEAEVWKGEVSELNKQK 245
+ K + K A ++ LQ S K + QQ+ EV+K +++E
Sbjct: 1226 VKTK-----------KELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE----- 1269
Query: 246 ITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGA 305
IT E K+H E + E H +TL+ + + + L+E+ + V S++E
Sbjct: 1270 ITSEKHKIH-EHLKTSAEQHQRTLSAY----QQRVTALQEECRAAKAEQATVTSEFE--- 1321
Query: 306 NLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQAS 365
+ + LK+ + + + + ER H+ + +D+ K +L + NLQ +
Sbjct: 1322 SYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEML---IDQLKIKLQDSQNNLQINVSE 1378
Query: 366 LQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKL-TVEENYRIEEEEKLSRVEEKIS 424
LQ+ +SE+ L ++ M + E +L KL +++ + + E V + S
Sbjct: 1379 LQT----LQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTS 1434
Query: 425 RATEGLETYRKLAKDLEEELERTVHFYQKQVISYE 459
+ ++R + L+EE +TV Q+Q+ E
Sbjct: 1435 QNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKME 1469
Score = 68.6 bits (166), Expect = 2e-11
Identities = 101/452 (22%), Positives = 192/452 (42%), Gaps = 70/452 (15%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKL 135
Q +G +L+ + EEKC L Q++ + E+E + K EE+ CE+L
Sbjct: 784 QAVGESLAKINEEKCNLA-----FQRDEKVLELEKEI------KCLQEES---VVQCEEL 829
Query: 136 NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC 195
+ E E + L K+L+E +S+ + ++ + + E+++L Q+ E C
Sbjct: 830 KSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTC 889
Query: 196 KTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHA 255
++ E+ IK+ +EN + K+L + AE+ I +DS +
Sbjct: 890 SKSEIHNEKEKCFIKE--HENLKPLLEQKELRDRRAEL------------ILLKDSLAKS 935
Query: 256 EQVLNDKENHIKTLTGHLPMMKDQ-------------AAVLEEDTTDDDNLELE-VNSQW 301
V ND + +K L + ++ + AV + D E + V +
Sbjct: 936 PSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEEL 995
Query: 302 ENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTK--------EELT 353
E+ + D L +++ LI A+ S K+L E QL +V+K + E+LT
Sbjct: 996 ESLRSEKDQLSASMRDLIQGAE---SYKNLLLEYEKQSEQL-DVEKERANNFEHRIEDLT 1051
Query: 354 EHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
++N Q ++ S+N + + LQ K++ E + K V++ E+
Sbjct: 1052 RQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQR---AKAMVDKELEAEKL 1108
Query: 414 EKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAE 473
+K +++E + E E +L K+ +++L++T+ Q + K+ A +T
Sbjct: 1109 QKEQKIKEHATTVNELEELQVQLQKE-KKQLQKTM-----QELELVKKD-----AQQTTL 1157
Query: 474 RN--LSDLRKENAHNKQKLTETELKFELLEKD 503
N ++D + QKLT K E LE++
Sbjct: 1158 MNMEIADYERLMKELNQKLTNKNNKIEDLEQE 1189
Score = 59.7 bits (143), Expect = 1e-08
Identities = 88/446 (19%), Positives = 193/446 (43%), Gaps = 64/446 (14%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKL 135
++L ++ L EEK + K +E + + + E E+ E + +E T +
Sbjct: 583 KELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCERE----ERLILELGKKVEQTIQY- 637
Query: 136 NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC 195
NSELE ++ L L+E + Q D+ + + ++ L ++ + L +++
Sbjct: 638 ---NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV------- 687
Query: 196 KTFKMSEERRAIAIKDALNENSQLQTSHKQ--------LFQQEAEVWKGEVSELNKQKIT 247
K EN++L + KQ L Q+E + K +++L K+
Sbjct: 688 --------------KSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQL 733
Query: 248 FEDSKVHAEQVL-NDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGAN 306
+ + + ++L N++ + T +K+ + + ED+ + D + + + + E+ A
Sbjct: 734 MVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNV-LQAVGESLAK 792
Query: 307 L-DDPLKGALKKLIHAAKLNVSLKSLEGER----NHIIIQLSEVDKTKEELTEHIKNLQT 361
+ ++ A ++ +L +K L+ E + L + ++ K L + ++ +Q+
Sbjct: 793 INEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQS 852
Query: 362 QQASLQSENIYFESENQKLQ---QKLKIMTEFYQE--NEMKLYRKLTVEENYRIEEEEKL 416
++ +LQS+ + ++ N+K + Q L I E + ++ +++ + +E I+E E L
Sbjct: 853 EKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNE---KEKCFIKEHENL 909
Query: 417 SRV---EEKISRATEGLETYRKLAKDLE---------EELERTVHFYQKQVISYEKRGHD 464
+ +E R E + LAK +ELE + +K+ E++ +
Sbjct: 910 KPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINK 969
Query: 465 NWLAARTAERNLSDLRKENAHNKQKL 490
L A A++ L RKE K++L
Sbjct: 970 IKLVAVKAKKELDSSRKETQTVKEEL 995
Score = 55.1 bits (131), Expect = 2e-07
Identities = 101/472 (21%), Positives = 199/472 (42%), Gaps = 71/472 (15%)
Query: 77 KLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLN 136
KL L+++ C+ EK IQK+YE LE+ + A A C L
Sbjct: 272 KLNELKENLVKQ-CEASEKN--IQKKYE-----CELENL---RKATSNANQDNQICSILL 320
Query: 137 RSNSELE----DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQI---- 188
+ N+ +E +++ LE LKE +S+HS + + ++ LE +++ +K +
Sbjct: 321 QENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHER 380
Query: 189 AEAKIICKTFKMSEERRAIAIKDALNENSQLQ-------TSHKQLFQQEAEVWKGEVSEL 241
+ + +++E + I+ +E + L H + Q E + E+SEL
Sbjct: 381 EDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISEL 440
Query: 242 NKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQW 301
N E L+D E TL + +K+Q L+++ + E +
Sbjct: 441 N-------------ETFLSDSEKEKLTLMFEIQGLKEQCENLQQE-------KQEAILNY 480
Query: 302 ENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKT----KEELTEHIK 357
E+ + + L+ L + A K++ +S++ ++ + +L + +T K+ L E +
Sbjct: 481 ESLREIMEILQTELGE--SAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVN 538
Query: 358 NLQTQQASLQS-ENIYFESEN--QKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEE 414
LQ + L S + + E EN + LQ+K + + + L ++L + N EE++
Sbjct: 539 RLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTML-KELEGKINSLTEEKD 597
Query: 415 ----KLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAAR 470
KL E++ + E +L +L +++E+T+ + + E N L
Sbjct: 598 DFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQY------NSELEQKVNELTG- 650
Query: 471 TAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHSPCS 522
L + KE N QKL + ++ ++L +D L + E++ S
Sbjct: 651 ----GLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLS 698
Score = 47.0 bits (110), Expect = 7e-05
Identities = 60/300 (20%), Positives = 130/300 (43%), Gaps = 24/300 (8%)
Query: 149 LEKDLKEEKSKHSQQDELMADISKS-IQSLEDESKSLKSQIAEAKIICKTFKMSEERRAI 207
LE KE+ K +++ ++ +KS LE E + L+S+ ++E A+
Sbjct: 22 LETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDAL 81
Query: 208 AIKDALNENSQLQTSHKQL-FQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHI 266
++ A E L + + +QE E ++ + +K+ E S ++ + + + +N +
Sbjct: 82 LLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKE---LEQSHINYVKEIENLKNEL 138
Query: 267 KTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNV 326
+ + A L++ + N +LE++ Q + N +D +K KL
Sbjct: 139 MAVRSKY---SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVK----------KLQE 185
Query: 327 SLKSLE-GERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLK 385
++ + G I+ ++D T +E E + LQ +++ + +++ LQ++L
Sbjct: 186 EIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQN---IIEANSQHYQKNINSLQEELL 242
Query: 386 IMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELE 445
+ +QE +L ++ E KL+ ++E + + E E + + K E ELE
Sbjct: 243 QLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASE--KNIQKKYECELE 300
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 79.3 bits (194), Expect = 1e-14
Identities = 99/441 (22%), Positives = 191/441 (43%), Gaps = 32/441 (7%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSL-IQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEK 134
+K TL E + K+LE+ + + + S + + K +E + L + ++
Sbjct: 539 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 598
Query: 135 LNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKII 194
+ S++E E ++K+L+ K K + +EL + LE E++ L+ +I KI
Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEEL----ENELHHLEKENELLQKKITNLKIT 654
Query: 195 CKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEA-EVWKGEVSELNKQKITFEDSKV 253
C+ + E+ + ++ L + FQ E+ E ++ E N + +S
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Query: 254 HAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKG 313
A + + K L +K +L+ + LE+ L L+
Sbjct: 715 CASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLEN 774
Query: 314 ALKKLIHAAKLNVSLKSLEGERNHIIIQLSEV---DKTKEELTEHIKNLQTQQASLQSEN 370
+ KK+ +L L+ LE E + L E+ K E+L + K+L+ + + L+ +
Sbjct: 775 SNKKI---QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 371 IYFESENQKLQQKLKIMTEFYQENEMK----------LYRKLTV--EENYRIEEEEKLSR 418
E EN++L+Q+ +I +EN +K L +++ + E R++E EK ++
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 419 VEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSD 478
E + RAT ++T L +DL E +T Q+ EK H+ ER L D
Sbjct: 892 --ELVKRATIDIKTLVTLREDLVSEKLKT----QQMNNDLEKLTHELEKIGLNKERLLHD 945
Query: 479 LRKENAHNKQKLTETELKFEL 499
+++ ++ KL E++L+ L
Sbjct: 946 --EQSTDDRYKLLESKLESTL 964
Score = 77.0 bits (188), Expect = 6e-14
Identities = 115/488 (23%), Positives = 200/488 (40%), Gaps = 80/488 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAA----EEARSLE 129
+ ++L + GL E +L + K+ + ++ES L+D E EE +
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQ--QLESELQDLEMENQTLQKNLEELKISS 807
Query: 130 ATCEKLNRSNSELEDEILCLEKDLK--EEKSKHSQQ-----DELMADISKSIQSLEDESK 182
E+L + N LE E LEKD K E+++K +Q D + + + I +LE E+K
Sbjct: 808 KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
Query: 183 SLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELN 242
+L +I K C K E+ +K A + L T + L +E K + +
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV---SEKLKTQQMNND 924
Query: 243 KQKITFEDSKV--------HAEQVLNDKENHIK-----TLTGHLPMMKDQAAV----LEE 285
+K+T E K+ H EQ +D+ ++ TL L + +++ A LEE
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 984
Query: 286 DTTDDDNLELEVNSQWENGANL------------DDPLKGALKKLIHAAK------LNVS 327
T + L E+ + +N L P+ G K ++ L V
Sbjct: 985 STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1044
Query: 328 LKSLEGERNHIII---------QLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQ 378
+ +E ERN+ + QL +++ L I LQ Q SLQ +N +++N
Sbjct: 1045 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104
Query: 379 KLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAK 438
KLQ + + + M +L ++++ E E + + E + Y L K
Sbjct: 1105 KLQVENSTLNS-QSTSLMNQNAQLLIQQSSLENENESVIKEREDLK------SLYDSLIK 1157
Query: 439 DLEEELERTVHFYQKQVISYE----KRGHDNWLAARTAERNLSDLRKENAHNKQKLTETE 494
D E+LE +++Q YE K G ++A +NL ++ +L + +
Sbjct: 1158 D-HEKLEL---LHERQASEYESLISKHG-----TLKSAHKNLEVEHRDLEDRYNQLLKQK 1208
Query: 495 LKFELLEK 502
+ E LEK
Sbjct: 1209 GQLEDLEK 1216
Score = 75.1 bits (183), Expect = 2e-13
Identities = 92/410 (22%), Positives = 176/410 (42%), Gaps = 34/410 (8%)
Query: 124 EARSLEATCEKLNRSNSELE---DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
E +SL T E+L + +E +IL +EK+ + K + + +S+Q+ ++
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
SK L + A+ + +T + + ER+ ++ +Q +S +Q Q AE ++ +
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
Query: 241 LNK-------------QKITFEDSKVHAE-QVLNDKENHIKTLTGHLPMMKDQAAVLEED 286
NK KI FE ++ E + +K + L L ++ + +L++
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 647
Query: 287 TTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVD 346
T+ ++ + + + L+ + K L L L+SLE E + QL E +
Sbjct: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEEN 703
Query: 347 KTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEM--KLYRKLTV 404
E +K + A LQ EN ESE ++L++ L+++ +++ E Y+ L +
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 405 EENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHD 464
EN R+ ++ L +KI + L+ + L++ LE + K++ EK
Sbjct: 764 -ENQRL--QKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-LKISSKRLEQLEKENKS 819
Query: 465 NWLAARTAERNLSDLRKENAHNKQK-------LTETELKFELLEKDPNAL 507
E++ L KEN +Q+ L E +K LEK+ L
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
Score = 59.7 bits (143), Expect = 1e-08
Identities = 83/389 (21%), Positives = 175/389 (44%), Gaps = 43/389 (11%)
Query: 134 KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI 193
K S L E+ + ++ + + ++ E + D + ++ +E E K L+ +
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 194 ICKTFKM-SEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSK 252
++ +M +E A+ K + + + S + + E +K V EL + ++K
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 253 VHAEQVLN------------DKEN-HIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNS 299
E L +KEN +K + M +D E+ ++ N+ LE+
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE-NMTLEMAQ 419
Query: 300 QWENGANLDDPLKGALKKLIHAAKLNVS-LKSLEGERNHIII-QLSEVDKTKEELTEHIK 357
+ +L L L+++ ++L+ + KSL E N + +L +++ + LT+ ++
Sbjct: 420 KQSMDESLH--LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 358 NLQTQQASLQ---SENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEE 414
L+T S++ S+ + E ENQ+L +K++I+ ENE+ V+E ++ +
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEIL-----ENEI-------VQEKQSLQNCQ 525
Query: 415 KLSR--VEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTA 472
LS+ ++EK ++ + +ET R+ ++ + LE+ + V S +R + +A
Sbjct: 526 NLSKDLMKEK-AQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR------SQISA 578
Query: 473 ERNLSDLRKENAHNKQKLTETELKFELLE 501
E + D+ KEN + + ET K +E
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIE 607
Score = 54.7 bits (130), Expect = 3e-07
Identities = 95/465 (20%), Positives = 192/465 (41%), Gaps = 69/465 (14%)
Query: 74 REQKLGATLSGLIEEKC----KLLEKFSLIQKEYEGYE--------VESSL----EDASF 117
+E+K+ A L +EE +L ++ ++K YE + V+SS ED +
Sbjct: 971 KEEKIAA-LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW 1029
Query: 118 EKAAAEEARSLEATCEKL---NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSI 174
E+ + E R L ++L R+N+ L+ E L+ LK+ +++++ + + +
Sbjct: 1030 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1089
Query: 175 QSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV- 233
SL++++ +L++Q A+ ++ T L + S L+ ++ + ++ ++
Sbjct: 1090 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1149
Query: 234 --WKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD 291
+ + + K ++ E E +++ G L V D D
Sbjct: 1150 SLYDSLIKDHEKLELLHERQASEYESLISKH--------GTLKSAHKNLEVEHRDLEDRY 1201
Query: 292 NLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSL----KSLEGERNHIIIQLSEVDK 347
N L+ Q E+ L+ LK +K++ K + ++ K L GE + + S++ K
Sbjct: 1202 NQLLKQKGQLED---LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1258
Query: 348 TKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIM--TEFYQENEMKLYRKL--- 402
E L KNL++ + + E E+E KL+++ + + T N+ +L +L
Sbjct: 1259 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1318
Query: 403 TVEENYRI------------------EEEEKLSRVEEKISRATEGLETYRKLAKDLEEEL 444
EEN + E + L VE++ + + L R+ + LEE++
Sbjct: 1319 LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR--QYIDKLNELRRQKEKLEEKI 1376
Query: 445 ERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQK 489
FY R NW+ + R L +K+ +QK
Sbjct: 1377 MDQYKFYDPS----PPRRRGNWITLKM--RKLIKSKKDINRERQK 1415
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 78.2 bits (191), Expect = 3e-14
Identities = 104/456 (22%), Positives = 198/456 (43%), Gaps = 50/456 (10%)
Query: 85 LIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEK--------AAAEEARSLEATCEKLN 136
L++E L + S + +YE V +LE A EK + EE L EKL
Sbjct: 2068 LVKESESLQARLS--ESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125
Query: 137 RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICK 196
E + L + + LKE + ++ + + ++ + +Q E+ + + +K +
Sbjct: 2126 VRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVE 2185
Query: 197 TFKMSEERRAIAIK----DALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFE--- 249
T K E A ++K D + S+ + KQ+ +++ G++SEL+K +F+
Sbjct: 2186 TLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQ-----GQLSELDKLLSSFKSLL 2240
Query: 250 DSKVHAE-QVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLD 308
+ K AE Q+ + + ++ L L + + A L D E+ E +LD
Sbjct: 2241 EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQ--------EIMKATEQ--SLD 2290
Query: 309 DPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQ--ASL 366
P++ + KL L++ E ++ ++ QL E + + L ++NL+ + A
Sbjct: 2291 PPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIART 2350
Query: 367 QSENIYFESENQK-----LQQKLKIMTEFYQENEMKLYRKLTVEENYRIE---EEEKLSR 418
E+ E+EN K L+ K++ MT+ + E+ + + +EN E E+E++S
Sbjct: 2351 NQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISE 2410
Query: 419 VEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRG---HDNWLAARTAERN 475
+E S L+ + ++E+ + Q Q+ +R H++ A + E+N
Sbjct: 2411 LEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN 2470
Query: 476 LSD----LRKENAHNKQKLTETELKFELLEKDPNAL 507
LS L E A Q L E + + +L+ N L
Sbjct: 2471 LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL 2506
Score = 58.2 bits (139), Expect = 3e-08
Identities = 90/436 (20%), Positives = 184/436 (42%), Gaps = 54/436 (12%)
Query: 72 VGREQKLGATLSGLIE-------EKCKLLEKFSLIQKEYEGYEVESSLED-----ASFEK 119
VG +K + LS +E E + +E + + E + +SS ED A
Sbjct: 1832 VGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVND 1891
Query: 120 AAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLED 179
+ E +E ++ + +E E L LE DL+ +++ ++ + K I LE+
Sbjct: 1892 SWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEE 1951
Query: 180 ESKSLKSQIAEAKIICKTFKMSEERRAI-AIKDALNENSQLQTSHKQLFQQEAEVWKGEV 238
E + S+ + + T MS++ A+ + + + E +Q SH+ +V + EV
Sbjct: 1952 ELSVVTSERNQLRGELDT--MSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
Query: 239 SELNKQKITFED-------SKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEED----T 287
E + T K H ++ L E + L+ +++Q A L ++
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLV 2069
Query: 288 TDDDNLELEVNSQWENGANLDDPLKGAL-------------KKLIH-----AAKLNVSLK 329
+ ++L+ ++ N+ L+ AL ++ +H KL V ++
Sbjct: 2070 KESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIE 2129
Query: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNL--QTQQASLQSENIYFESENQK-----LQQ 382
+ E ++ HI +L E ++ + L + ++NL + Q + E + ++EN K L+
Sbjct: 2130 ADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKT 2189
Query: 383 KLKIMTEFYQENEMKLYRKLTVEENYRIEEEEK---LSRVEEKISRATEGLETYRKLAKD 439
+++ M + E+ L + +EN + +EK LS +++ +S LE +
Sbjct: 2190 QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ 2249
Query: 440 LEEELERTVHFYQKQV 455
++EE + V Q Q+
Sbjct: 2250 IKEESKTAVEMLQNQL 2265
Score = 52.8 bits (125), Expect = 1e-06
Identities = 86/381 (22%), Positives = 160/381 (41%), Gaps = 49/381 (12%)
Query: 107 EVESSLEDASFE-KAAAEEARSLEATCEKLNRSNSELED---EILCLEKDLKEEKSKHSQ 162
E S+LE+ E + ++ + +A ++L +SN LED E+ L + L EK + S
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMS- 959
Query: 163 QDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTS 222
+++ + I+ L E+ +LK I +LN+
Sbjct: 960 --SIISLNKREIEELTQENGTLKE----------------------INASLNQEKMNLIQ 995
Query: 223 HKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAV 282
+ F + + +SEL+ Q ++ K+ Q + N + L+ K +AA
Sbjct: 996 KSESFANYIDEREKSISELSDQ---YKQEKLILLQRCEETGNAYEDLS-----QKYKAA- 1046
Query: 283 LEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQL 342
+E + + L E S EN N + LK A K + L E +++++L
Sbjct: 1047 -QEKNSKLECLLNECTSLCENRKNELEQLKEAFAK--EHQEFLTKLAFAEERNQNLMLEL 1103
Query: 343 SEVDKT-KEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRK 401
V + + E+T++ N +++ L+ E + + E K+Q K + + QENE +
Sbjct: 1104 ETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQ---KEVNDLLQENEQLMKVM 1160
Query: 402 LTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKR 461
T E +E E + V+E R +E + K DLE + E ++ Y Q++ E
Sbjct: 1161 KTKHECQNLESEPIRNSVKE---RESERNQCNFKPQMDLEVK-EISLDSYNAQLVQLEAM 1216
Query: 462 GHDNWLAARTAERNLSDLRKE 482
+ L + +E+ L+ E
Sbjct: 1217 LRNKELKLQESEKEKECLQHE 1237
Score = 50.8 bits (120), Expect = 5e-06
Identities = 97/470 (20%), Positives = 194/470 (41%), Gaps = 73/470 (15%)
Query: 59 LWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFE 118
L S +R+RL +++L L L E + L++ E E E + + E
Sbjct: 2299 LRNSIEKLRARLEADEKKQL-CVLQQLKESE----HHADLLKGRVENLERELEIARTNQE 2353
Query: 119 KAAAE------EARSLEATCEKLNRSNSELEDEILCL---EKDLKEEKSKHSQQDELMAD 169
AA E E +L+A E + +S LE +++ + +++L E K ++ +
Sbjct: 2354 HAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI 2413
Query: 170 ISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQ 229
I+ S +++ E + K Q+ +E+ + A++ LQT K+L ++
Sbjct: 2414 INSSFENILQEKEQEKVQM-------------KEKSSTAME-------MLQTQLKELNER 2453
Query: 230 EA------EVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHI----KTLTGHLPMMKDQ 279
A E K + L+ Q E K Q L++ +N+ ++ G + ++D
Sbjct: 2454 VAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDG 2513
Query: 280 AAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHII 339
LE+ + L+ ++ Q +L L +EGE
Sbjct: 2514 KQKLEKKDEEISRLKNQIQDQ---------------------EQLVSKLSQVEGEHQLWK 2552
Query: 340 IQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLY 399
Q E+ EL + I+ LQ++ ASLQ +S + L+ +L+ +T+ + + ++
Sbjct: 2553 EQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE-LTKMDKMSFVEKV 2611
Query: 400 RKLTVEENYRIEEEEKLSRVEEKISRATEGLETYR-KLAKDLE---EELERTVHFYQKQV 455
K+T +E E + ++ + +K + E L + +LA +L+ EE++ + ++
Sbjct: 2612 NKMTAKET---ELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELT 2668
Query: 456 ISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPN 505
+ + + +R+E A + +L E E K + L D N
Sbjct: 2669 LENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTN 2718
Score = 49.7 bits (117), Expect = 1e-05
Identities = 86/433 (19%), Positives = 182/433 (42%), Gaps = 54/433 (12%)
Query: 85 LIEEKCKLLEKFSLIQK-EYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELE 143
L + K +L+EK ++ K E + + AS + A E+ L+ E L+ E
Sbjct: 322 LEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQ--KLKKLTEDLSCQRQNAE 379
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFK---M 200
LE+ +KE++ + Q+EL +S Q+L+ E +K+++ + K
Sbjct: 380 SARCSLEQKIKEKEKEF--QEELSRQ-QRSFQTLDQECIQMKARLTQELQQAKNMHNVLQ 436
Query: 201 SEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKV------- 253
+E + ++K L N L+ ++L + E ++ E N+ + + E+ K
Sbjct: 437 AELDKLTSVKQQLENN--LEEFKQKLCRAEQAFQASQIKE-NELRRSMEEMKKENNLLKS 493
Query: 254 HAEQVLNDK---ENHIKTLTGHLPMMKDQAAVLEEDTTDDD----NLELEVNSQWENGAN 306
H+EQ + E +K + L ++ A ++ T + +L+ ++N Q EN
Sbjct: 494 HSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ-ENSLT 552
Query: 307 LDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASL 366
L+ KL +++ LE +R+ L + + E+L + + + + +L
Sbjct: 553 LE--------------KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL 598
Query: 367 QSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRA 426
S + E ++L+++ + + + ENE L + + +EN + K++ +E +
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENL----QSKINHLETCLKTQ 654
Query: 427 TEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHN 486
Y + + LE + E +S E R N L +++ E L
Sbjct: 655 QIKSHEYNERVRTLEMDREN---------LSVEIRNLHNVLDSKSVEVETQKLAYMELQQ 705
Query: 487 KQKLTETELKFEL 499
K + ++ + + E+
Sbjct: 706 KAEFSDQKHQKEI 718
Score = 48.9 bits (115), Expect = 2e-05
Identities = 89/439 (20%), Positives = 178/439 (40%), Gaps = 62/439 (14%)
Query: 126 RSLEATCEKLNRSNSELED----------EILCLEKDLKEEKSKHSQQDELMADISKSIQ 175
+ +E C K ++ ++ED EI+ ++ ++ +++ +L+ S+
Sbjct: 716 KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLV 775
Query: 176 SLEDESKSLKSQIAE-------AKIICKTFKMSEERRAIAIK-DALNENSQLQTSHKQLF 227
+ ED +SL + + A II + M ER ++ D +NS + +
Sbjct: 776 TNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSL 835
Query: 228 QQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDT 287
+ E K S+L KQ K E+ L E ++ + + L+EDT
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAET---SQRISKLQEDT 892
Query: 288 TDDDNLELEVNSQWENGAN----LDDPLKGALKKLIHAAKLNVSLK-------------S 330
+ N+ E S EN L+D ++ ++ K N L+ S
Sbjct: 893 SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLS 952
Query: 331 LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSE--NIYFESEN-----QKLQQK 383
LE + II L++ + EELT+ L+ ASL E N+ +SE+ + ++
Sbjct: 953 LEKKEMSSIISLNK--REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKS 1010
Query: 384 LKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEE 443
+ +++ Y++ ++ L ++ N + +K +EK S+ L L ++ + E
Sbjct: 1011 ISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNE 1070
Query: 444 LERTVHFYQKQVISY-------EKRGHDNWLAARTAERNLSDLRKENAHN--------KQ 488
LE+ + K+ + E+R + L T ++ L +N +N KQ
Sbjct: 1071 LEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130
Query: 489 KLTETELKFELLEKDPNAL 507
++ + + ++K+ N L
Sbjct: 1131 EIMTLKEEQNKMQKEVNDL 1149
Score = 47.8 bits (112), Expect = 4e-05
Identities = 75/369 (20%), Positives = 151/369 (40%), Gaps = 41/369 (11%)
Query: 138 SNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKT 197
S S+ ED K+++E K ++ L A K+ Q+L + + + IA +
Sbjct: 160 SGSKYEDLKEKYNKEVEERKRLEAEVKALQA--KKASQTLPQATMNHRD-IARHQASSSV 216
Query: 198 FKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQ 257
F +E+ L+ NSQ + A + GE E+ + T + K A
Sbjct: 217 FSWQQEKTP----SHLSSNSQRTPIRRDF---SASYFSGE-QEVTPSRSTLQIGKRDANS 268
Query: 258 VLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKK 317
D + P + DQ ++ + N ELE+ Q + +KG + K
Sbjct: 269 SFFDNSSS--------PHLLDQLKAQNQELRNKIN-ELELRLQGH-----EKEMKGQVNK 314
Query: 318 L----IHAAKLNVSL----KSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ--TQQASLQ 367
+ K V L K L R+ ++ ++ D+ + T + L+ T+ S Q
Sbjct: 315 FQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQ 374
Query: 368 SENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRAT 427
+N ES L+QK+K + +QE + R + I+ + +L++ ++
Sbjct: 375 RQNA--ESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMH 432
Query: 428 EGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKEN---- 483
L+ ++++LE + +++++ E+ + + R++ +++KEN
Sbjct: 433 NVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK 492
Query: 484 AHNKQKLTE 492
+H++QK E
Sbjct: 493 SHSEQKARE 501
Score = 40.8 bits (94), Expect = 0.005
Identities = 57/307 (18%), Positives = 131/307 (42%), Gaps = 25/307 (8%)
Query: 71 YVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEA 130
+V + K+ A + L E ++ +K + +Q+E G + + E + EE +S +
Sbjct: 2607 FVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE----LQLLLEEIKSSKD 2662
Query: 131 TCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQI-A 189
++L NSEL+ + C+ KD E++ K ++ +A+ + E + ++L
Sbjct: 2663 QLKELTLENSELKKSLDCMHKDQVEKEGKVREE---IAEYQLRLHEAEKKHQALLLDTNK 2719
Query: 190 EAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFE 249
+ ++ +T++ + + E L++S ++L K L + K T
Sbjct: 2720 QYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNS----LKATTQILEELKKTKM 2775
Query: 250 DSKVHAEQVLNDKE---NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGAN 306
D+ + Q+ + E +K L ++++ +L+++ + +L+ + +
Sbjct: 2776 DNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELS-----QLQAAQEKQKTGT 2830
Query: 307 LDDPLKGALKKLIHAAKLNVSLKSLEGERN-----HIIIQLSEVDKTKEELTEHIKNLQT 361
+ D L I K + K+ E + ++I +++K KE L + +L +
Sbjct: 2831 VMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCS 2890
Query: 362 QQASLQS 368
QQ+ S
Sbjct: 2891 QQSKQDS 2897
Score = 36.6 bits (83), Expect = 0.091
Identities = 80/387 (20%), Positives = 149/387 (38%), Gaps = 40/387 (10%)
Query: 141 ELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLED---ESKSLKSQIAEAKIICKT 197
ELE + L+K KE++ + Q D L A + K Q +E+ E +LK + IC++
Sbjct: 22 ELEGQ---LDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICES 78
Query: 198 FKMSEER--RAIAIKDA-LN-ENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKV 253
+ ++++ + +K++ +N + QL + KQ+ + E E+ K SEL + + +
Sbjct: 79 LEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQEL-KRCKSELERS----QQAAQ 133
Query: 254 HAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWE------NGANL 307
A+ LN K T L + + ED + N E+E + E
Sbjct: 134 SADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKA 193
Query: 308 DDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKT--------------KEELT 353
L A A+ S ++ LS + ++E+T
Sbjct: 194 SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVT 253
Query: 354 EHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
LQ + S + + S + L +LK + + +L +L E +
Sbjct: 254 PSRSTLQIGKRDANS-SFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQV 312
Query: 414 EKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAE 473
K ++ ++ +A L K+ +EL RT Y + Y + L T +
Sbjct: 313 NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKY--TALEQKLKKLTED 370
Query: 474 RNLSDLRKENAH--NKQKLTETELKFE 498
+ E+A +QK+ E E +F+
Sbjct: 371 LSCQRQNAESARCSLEQKIKEKEKEFQ 397
Score = 33.9 bits (76), Expect = 0.59
Identities = 95/461 (20%), Positives = 181/461 (39%), Gaps = 54/461 (11%)
Query: 82 LSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSE 141
L L E + LEK ++++ E + + E E+ + E + L+ ++ N +
Sbjct: 1552 LESLCEVYRQSLEK---LEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQ 1608
Query: 142 LEDEI----LCLEKDLKEEKSKHSQQDELMADISK-SIQSLEDESKSLKSQIAEAKIICK 196
+ ++ L +E L EK K ++Q L ++++ +Q L+ S+SL E I
Sbjct: 1609 WQQKLTSVTLEMESKLAAEK-KQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAI--- 1664
Query: 197 TFKMSEERRAIAIKDALNENSQLQTSHK------QLFQQEAEVWKGEVSELNKQKITFED 250
K+ +E ++ H + QQ+ + +++E K T E
Sbjct: 1665 ---QGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGEC 1721
Query: 251 S-----KVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEE---DTTDDDNLELEVNSQWE 302
S + E DK L A V + + D NL+L V
Sbjct: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781
Query: 303 NGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ 362
L ++ +K+ L +K L+ + + +QL + EL + + L+ +
Sbjct: 1782 ENLRLLHVIEDRDRKV---ESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKE 1838
Query: 363 QASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRK---------LTVEENYR---I 410
+ L + YF ++Q+L Q+++ + EM + V ++++ +
Sbjct: 1839 NSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFL 1898
Query: 411 EEEEKLSRV-EEKISRATEGLETYRKLAKDLEEE--LERTVHFYQKQVISYEKRGHDNWL 467
+ E +LSR+ EK S E L L E+ LE+ QK ++ E+ L
Sbjct: 1899 DVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEE-----L 1953
Query: 468 AARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALD 508
+ T+ERN LR E +K T + E +++ L+
Sbjct: 1954 SVVTSERN--QLRGELDTMSKKTTALDQLSEKMKEKTQELE 1992
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 77.8 bits (190), Expect = 4e-14
Identities = 99/441 (22%), Positives = 189/441 (42%), Gaps = 31/441 (7%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSL-IQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEK 134
+K TL E + K+LE+ + + + S + + K +E + L + ++
Sbjct: 539 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 598
Query: 135 LNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKII 194
+ S++E E ++K+L+ K K + +EL + LE E++ L+ +I KI
Sbjct: 599 TSSKLSKIEFEKRQIKKELEHYKEKGERAEEL----ENELHHLEKENELLQKKITNLKIT 654
Query: 195 CKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEA-EVWKGEVSELNKQKITFEDSKV 253
C+ + E+ + ++ L + FQ E+ E ++ E N + +S
Sbjct: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
Query: 254 HAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKG 313
A + + K L +K +L+ + LE+ L L+
Sbjct: 715 CASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLEN 774
Query: 314 ALKKLIHAAKLNVSLKSLEGERNHIIIQLSEV---DKTKEELTEHIKNLQTQQASLQSEN 370
+ KK+ +L L+ LE E + L E+ K E+L + K+L+ + + L+ +
Sbjct: 775 SNKKI---QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 371 IYFESENQKLQQKLKIMTEFYQENEMK----------LYRKLTV--EENYRIEEEEKLSR 418
E EN++L+Q+ +I +EN +K L +++ + E R++E EK ++
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 419 VEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSD 478
E + RAT ++T L +DL E +T Q+ EK H+ ER L D
Sbjct: 892 --ELVKRATIDIKTLVTLREDLVSEKLKT----QQMNNDLEKLTHELEKIGLNKERLLHD 945
Query: 479 LRKENAHNKQKLTETELKFEL 499
+ ++ KL E++L+ L
Sbjct: 946 -EQSTDDSRYKLLESKLESTL 965
Score = 76.3 bits (186), Expect = 1e-13
Identities = 115/489 (23%), Positives = 198/489 (40%), Gaps = 81/489 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAA----EEARSLE 129
+ ++L + GL E +L + K+ + ++ES L+D E EE +
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQ--QLESELQDLEMENQTLQKNLEELKISS 807
Query: 130 ATCEKLNRSNSELEDEILCLEKDLK--EEKSKHSQQ-----DELMADISKSIQSLEDESK 182
E+L + N LE E LEKD K E+++K +Q D + + + I +LE E+K
Sbjct: 808 KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
Query: 183 SLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELN 242
+L +I K C K E+ +K A + L T + L +E K + +
Sbjct: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV---SEKLKTQQMNND 924
Query: 243 KQKITFEDSKV--------HAEQVLNDKENHI------KTLTGHLPMMKDQAAV----LE 284
+K+T E K+ H EQ +D + TL L + +++ A LE
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE 984
Query: 285 EDTTDDDNLELEVNSQWENGANL------------DDPLKGALKKLIHAAK------LNV 326
E T + L E+ + +N L P+ G K ++ L V
Sbjct: 985 ESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKV 1044
Query: 327 SLKSLEGERNHIII---------QLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESEN 377
+ +E ERN+ + QL +++ L I LQ Q SLQ +N +++N
Sbjct: 1045 KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN 1104
Query: 378 QKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLA 437
KLQ + + + M +L ++++ E E + + E + Y L
Sbjct: 1105 AKLQVENSTLNS-QSTSLMNQNAQLLIQQSSLENENESVIKEREDLK------SLYDSLI 1157
Query: 438 KDLEEELERTVHFYQKQVISYE----KRGHDNWLAARTAERNLSDLRKENAHNKQKLTET 493
KD E+LE +++Q YE K G ++A +NL ++ +L +
Sbjct: 1158 KD-HEKLEL---LHERQASEYESLISKHG-----TLKSAHKNLEVEHRDLEDRYNQLLKQ 1208
Query: 494 ELKFELLEK 502
+ + E LEK
Sbjct: 1209 KGQLEDLEK 1217
Score = 75.1 bits (183), Expect = 2e-13
Identities = 92/410 (22%), Positives = 176/410 (42%), Gaps = 34/410 (8%)
Query: 124 EARSLEATCEKLNRSNSELE---DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDE 180
E +SL T E+L + +E +IL +EK+ + K + + +S+Q+ ++
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 181 SKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSE 240
SK L + A+ + +T + + ER+ ++ +Q +S +Q Q AE ++ +
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
Query: 241 LNK-------------QKITFEDSKVHAE-QVLNDKENHIKTLTGHLPMMKDQAAVLEED 286
NK KI FE ++ E + +K + L L ++ + +L++
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 647
Query: 287 TTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVD 346
T+ ++ + + + L+ + K L L L+SLE E + QL E +
Sbjct: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEEN 703
Query: 347 KTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEM--KLYRKLTV 404
E +K + A LQ EN ESE ++L++ L+++ +++ E Y+ L +
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 405 EENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHD 464
EN R+ ++ L +KI + L+ + L++ LE + K++ EK
Sbjct: 764 -ENQRL--QKTLENSNKKIQQLESELQDLEMENQTLQKNLEE-LKISSKRLEQLEKENKS 819
Query: 465 NWLAARTAERNLSDLRKENAHNKQK-------LTETELKFELLEKDPNAL 507
E++ L KEN +Q+ L E +K LEK+ L
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
Score = 59.7 bits (143), Expect = 1e-08
Identities = 83/389 (21%), Positives = 175/389 (44%), Gaps = 43/389 (11%)
Query: 134 KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI 193
K S L E+ + ++ + + ++ E + D + ++ +E E K L+ +
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 194 ICKTFKM-SEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSK 252
++ +M +E A+ K + + + S + + E +K V EL + ++K
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 253 VHAEQVLN------------DKEN-HIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNS 299
E L +KEN +K + M +D E+ ++ N+ LE+
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE-NMTLEMAQ 419
Query: 300 QWENGANLDDPLKGALKKLIHAAKLNVS-LKSLEGERNHIII-QLSEVDKTKEELTEHIK 357
+ +L L L+++ ++L+ + KSL E N + +L +++ + LT+ ++
Sbjct: 420 KQSMDESLH--LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
Query: 358 NLQTQQASLQ---SENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEE 414
L+T S++ S+ + E ENQ+L +K++I+ ENE+ V+E ++ +
Sbjct: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEIL-----ENEI-------VQEKQSLQNCQ 525
Query: 415 KLSR--VEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTA 472
LS+ ++EK ++ + +ET R+ ++ + LE+ + V S +R + +A
Sbjct: 526 NLSKDLMKEK-AQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQR------SQISA 578
Query: 473 ERNLSDLRKENAHNKQKLTETELKFELLE 501
E + D+ KEN + + ET K +E
Sbjct: 579 EARVKDIEKENKILHESIKETSSKLSKIE 607
Score = 54.7 bits (130), Expect = 3e-07
Identities = 95/465 (20%), Positives = 192/465 (41%), Gaps = 69/465 (14%)
Query: 74 REQKLGATLSGLIEEKC----KLLEKFSLIQKEYEGYE--------VESSL----EDASF 117
+E+K+ A L +EE +L ++ ++K YE + V+SS ED +
Sbjct: 972 KEEKIAA-LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW 1030
Query: 118 EKAAAEEARSLEATCEKL---NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSI 174
E+ + E R L ++L R+N+ L+ E L+ LK+ +++++ + + +
Sbjct: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090
Query: 175 QSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV- 233
SL++++ +L++Q A+ ++ T L + S L+ ++ + ++ ++
Sbjct: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1150
Query: 234 --WKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD 291
+ + + K ++ E E +++ G L V D D
Sbjct: 1151 SLYDSLIKDHEKLELLHERQASEYESLISKH--------GTLKSAHKNLEVEHRDLEDRY 1202
Query: 292 NLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSL----KSLEGERNHIIIQLSEVDK 347
N L+ Q E+ L+ LK +K++ K + ++ K L GE + + S++ K
Sbjct: 1203 NQLLKQKGQLED---LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1259
Query: 348 TKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIM--TEFYQENEMKLYRKL--- 402
E L KNL++ + + E E+E KL+++ + + T N+ +L +L
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1319
Query: 403 TVEENYRI------------------EEEEKLSRVEEKISRATEGLETYRKLAKDLEEEL 444
EEN + E + L VE++ + + L R+ + LEE++
Sbjct: 1320 LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR--QYIDKLNELRRQKEKLEEKI 1377
Query: 445 ERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQK 489
FY R NW+ + R L +K+ +QK
Sbjct: 1378 MDQYKFYDPS----PPRRRGNWITLKM--RKLIKSKKDINRERQK 1416
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 75.9 bits (185), Expect = 1e-13
Identities = 100/449 (22%), Positives = 191/449 (42%), Gaps = 47/449 (10%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEI 146
++K + LE +L+QK E + + + K A E + A +L N L++++
Sbjct: 522 DQKIQNLE--ALLQKSKENISLLEKEREDLYAKIQAGEGET--AVLNQLQEKNHTLQEQV 577
Query: 147 LCLEKDLKEEKSKHSQQDELMADISKS----IQSLEDESKSLKSQIAEAKIICKTFKMSE 202
L + LK + H Q E + D + +++ +D SL++ + E K
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 203 ERRAIAIK---DALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQ--KITFEDSKVHAEQ 257
+ I IK + L +T+ + Q + + + + ++ KIT + +V A+
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK- 696
Query: 258 VLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKK 317
L DK+ H L HL K++ LE+ T + LE ++ + + + AL+
Sbjct: 697 -LQDKQEHCSQLESHLKEYKEKYLSLEQKT---EELEGQIKKLEADSLEVKASKEQALQD 752
Query: 318 LIHAAKLNVSL--------KSLEGERNHIIIQLSEVD-KTKEELTEHIKNLQTQQASLQS 368
L +LN L K LE E+ I+ + +D + K E E IK T+Q +
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKE--IVSSTRLDLQKKSEALESIKQKLTKQ---EE 807
Query: 369 ENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE---EKLSRVEEKISR 425
E + + + L Q+ KI ++E ++ +T + ++E+E +LS V++K+S+
Sbjct: 808 EKQILKQDFETLSQETKIQ---HEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSK 864
Query: 426 ATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKE--N 483
++ L K+ + E E+ + ++ EK + + N +KE
Sbjct: 865 VSDSL-------KNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 484 AHNKQKLTETELKFELLEKDPNALDVSNT 512
+ K+K +LK EL + NT
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQLIQAQNT 946
Score = 70.5 bits (171), Expect = 6e-12
Identities = 94/457 (20%), Positives = 188/457 (41%), Gaps = 58/457 (12%)
Query: 87 EEKCKLLEKFSLIQKEY---EGYEVESSLEDASFEKAAAE---EARSLEATCEKLNRSNS 140
EE K LEK+ +Q++ +G +SS E S E+ E E +++ + + +
Sbjct: 107 EELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAA 166
Query: 141 ELEDEILCLEKDLKEEKSKHSQQDELMADISKS-------IQSLEDESKS---------L 184
+L EI ++ EE+S ++ + +++ IQ L+ E L
Sbjct: 167 QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVL 226
Query: 185 KSQIAEAKIICKTFKMSEERRAIAIKDALNE-NSQLQTSHKQLFQQEAEVWKGE------ 237
K ++ + + + + ER + +KD + SQ +S + Q +E+ KG
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
Query: 238 VSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD----NL 293
V EL K K + +N+ +TLT +L + LEE ++ N+
Sbjct: 287 VQELQKLKSS-----------VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI 335
Query: 294 ELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELT 353
+ ++ + + L L + L +++V L + +LSEV+ + L
Sbjct: 336 QATLHQKDLDCQQLQSRLSASETSL---HRIHVELSEKGEATQKLKEELSEVETKYQHLK 392
Query: 354 EHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
K LQ Q+ + + +SE +L KL E +L + + +++E
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKE 452
Query: 414 EKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAE 473
++++ ++ K+SR E L+ + +L+ +L++T +Q+Q + R A+
Sbjct: 453 QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ----QALQQSTTAKLREAQ 508
Query: 474 RNLSDLRKENAHNKQKLTETEL-------KFELLEKD 503
+L + ++ QK+ E LLEK+
Sbjct: 509 NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545
Score = 69.3 bits (168), Expect = 1e-11
Identities = 101/427 (23%), Positives = 195/427 (45%), Gaps = 48/427 (11%)
Query: 94 EKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDL 153
EK+ ++++ E E + +A + A + ++L+ ++ + N++LE L K L
Sbjct: 716 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQ-DLQQQRQLNTDLELRATELSKQL 774
Query: 154 KEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDAL 213
+ EK S D+ K ++LE + L Q E +I+ + F+ + I ++ L
Sbjct: 775 EMEKEIVSST---RLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEE-L 830
Query: 214 NENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHL 273
N Q + Q + E E E+S + + DS +++ +KEN
Sbjct: 831 NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEF-EKENQ-------- 881
Query: 274 PMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAA-KLNVSLKSLE 332
K +AA+L+ + T + L+ ++ Q EN LK +L+K A+ +L + L S++
Sbjct: 882 ---KGKAAILDLEKTCKE-LKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ 937
Query: 333 GERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQ 392
+ L + +K +++L +I L+ Q+S Q + + + LQ +LKI
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQGNINELK--QSSEQKKK-----QIEALQGELKIAVLQKT 990
Query: 393 ENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDL---EEEL----- 444
E E KL ++LT E+EK+S ++ ++ ET+++L D E EL
Sbjct: 991 ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ---ETFKQLQSDFYGRESELLATRQ 1047
Query: 445 -----ERTVHFYQKQVISYEKR-GHDNWL--AARTAERNLSDLRKENAHNKQKLTETELK 496
E + Q+ +IS + G+ N L +TA+ + L +++A +Q+L E
Sbjct: 1048 DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAK---ATLEQDSAKKEQQLQERCKA 1104
Query: 497 FELLEKD 503
+ ++K+
Sbjct: 1105 LQDIQKE 1111
Score = 66.6 bits (161), Expect = 8e-11
Identities = 97/485 (20%), Positives = 204/485 (42%), Gaps = 82/485 (16%)
Query: 70 LYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLE 129
+YV QKL ++++ L ++ L E +L++KE + ++E + S K ++++
Sbjct: 285 VYVQELQKLKSSVNELTQKNQTLTE--NLLKKEQDYTKLEEKHNEESVSK------KNIQ 336
Query: 130 ATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIA 189
AT + + +L+ + E L + S++ E + + + +E + + LK++
Sbjct: 337 ATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE-- 394
Query: 190 EAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG-----EVSELNKQ 244
FK +++R + L S++ H +L + E ++ + E +L+ +
Sbjct: 395 --------FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE 446
Query: 245 KITFEDSKV--------HAEQVLNDKENHIKTLTGHLPMMK----DQAAVLEEDTTDDDN 292
K+ ++ +V E+ L +K + L L K +Q A+ + T
Sbjct: 447 KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
Query: 293 LELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGE-----------RNHIIIQ 341
+ ++ + D ++ L+ L+ +K N+SL E E ++ Q
Sbjct: 507 AQNDLEQVLRQIGDKDQKIQN-LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
Query: 342 LSEVDKTKEE----LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMK 397
L E + T +E LTE +KN Q++ EN++ + + QK + Q+ +
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKN-QSESHKQAQENLHDQVQEQKAHLRAA------QDRVLS 618
Query: 398 LYRKLTVEENYRIEEEEKLSRVEEKISRATE------------------GLETYRKLAKD 439
L + + E +EK+S+++ +I TE L+T + +D
Sbjct: 619 LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678
Query: 440 LEEELER-TVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFE 498
++EL + T Q +K+ H + L E +L + +++ +QK E E + +
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQL-----ESHLKEYKEKYLSLEQKTEELEGQIK 733
Query: 499 LLEKD 503
LE D
Sbjct: 734 KLEAD 738
Score = 65.9 bits (159), Expect = 1e-10
Identities = 81/340 (23%), Positives = 157/340 (46%), Gaps = 44/340 (12%)
Query: 62 SFRSVRSRLYVGREQKLGATLSGL--IEEKCKLLEKFSLIQKEYEGYE----VESSLEDA 115
+F+ ++S Y GRE +L AT L +EEK L ++ + + G + E A
Sbjct: 1027 TFKQLQSDFY-GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085
Query: 116 SFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQ 175
+ E+ +A++ + L+ C+ L +++ E EK+L EKSK ++ +E+ K I
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQ----DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEIT 1141
Query: 176 SLEDESKSLK-------SQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQ 228
L +E KS K + + +AK + K+ + +A ++K A+ + + Q K +
Sbjct: 1142 KLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201
Query: 229 QEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTT 288
+E E K E E +++K+H+E + +KE G +++A + + T
Sbjct: 1202 KEEEELKKEFIE--------KEAKLHSE--IKEKE------VGMKKHEENEAKLTMQITA 1245
Query: 289 DDDNLELEVNSQWENGANLDDPLKGALKKLI-HAAKLNVSLKSLEGERNHIIIQL----S 343
++NL V +W++ L+ L A L ++++ + ER ++ +
Sbjct: 1246 LNENLG-TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEG 1304
Query: 344 EVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK 383
E++K + ++ E + L A++Q ENQ LQ K
Sbjct: 1305 EIEKLQTKVLELQRKLDNTTAAVQE----LGRENQSLQIK 1340
Score = 59.3 bits (142), Expect = 1e-08
Identities = 83/448 (18%), Positives = 182/448 (40%), Gaps = 46/448 (10%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKL 135
Q+ TL + + + L+ S K+ + + E + +AA + SLE + +L
Sbjct: 567 QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626
Query: 136 NRSNSELEDEILCLEKDLK--------EEKSKHSQQDELMADISKSIQSLEDESKSLKSQ 187
N +E ++++ L+ +K E +K +Q+ +L + + +L+D+ + L
Sbjct: 627 NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686
Query: 188 IAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKIT 247
+ + + +E ++ L E + S +Q+ E +G++ +L +
Sbjct: 687 TTQLDQVTAKLQDKQE-HCSQLESHLKEYKEKYLS----LEQKTEELEGQIKKLEADSLE 741
Query: 248 FEDSKVHA-------EQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
+ SK A Q+ D E L+ L M K+ + D + +
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
LK + L K + + L + +L +V KE L + ++
Sbjct: 802 LTKQEEEKQILKQDFETLSQETK--IQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859
Query: 361 TQQA----SLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKL 416
+ + SL++ FE ENQK + + + + +E L +L V+ ++E+++L
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKE----LKHQLQVQMENTLKEQKEL 915
Query: 417 SRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNL 476
+ EK K+ +L+ ++ Q+Q+I + N + + N+
Sbjct: 916 KKSLEK--------------EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
Query: 477 SDLRKENAHNKQKL--TETELKFELLEK 502
++L++ + K+++ + ELK +L+K
Sbjct: 962 NELKQSSEQKKKQIEALQGELKIAVLQK 989
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 75.9 bits (185), Expect = 1e-13
Identities = 104/474 (21%), Positives = 211/474 (44%), Gaps = 81/474 (17%)
Query: 76 QKLGATLSGLIEEK----CKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEAT 131
++L + L++EK C++ E +QK + + D + E E
Sbjct: 1357 EELHHNIDDLLQEKKSLECEVEELHRTVQKRQQ----QKDFIDGNVESLMTE------LE 1406
Query: 132 CEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEA 191
EK + + ++ DEI C+EK L + +S+ + D L+A+ + ++++K+ + +A
Sbjct: 1407 IEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDA 1466
Query: 192 K-IICKTFKMSEERRAIAIKDALN------ENSQLQTSHKQLFQ---QEAEVWKGEVSEL 241
K + +T +EE A + A+N + LQ K L Q ++ E+ K E++++
Sbjct: 1467 KRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILK-EINKI 1525
Query: 242 -------------NKQKITFEDSKVHAE-QVLNDKENHIKTLTGHLPMMKDQAAVLEEDT 287
K+K+T E K+ + ++ E+H HL ++K+ +L+
Sbjct: 1526 VAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDH------HLQVLKESEVLLQAKR 1579
Query: 288 TDDDNLELEVNSQWENGANLDDPLKGALKKLIH---------AAKLNVSLKSLEGERNHI 338
+ + L+ +V SQ + A LD L G K+ +H A L +L+ E E
Sbjct: 1580 AELEKLKSQVTSQQQEMAVLDRQL-GHKKEELHLLQGSMVQAKADLQEALRLGETEVTEK 1638
Query: 339 IIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKL 398
+ EV EEL+ L Q + +++ + E +K ++ L+++ +++ +L
Sbjct: 1639 CNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTEL 1698
Query: 399 -------------YRKLTVEENYRIEEEEK--LSRVEEKISRATEGLETYRKLAKDLEEE 443
+ L ++ + R+ E EK ++ +EEK+ LE +++++ + E
Sbjct: 1699 KNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLE-----LENLQQISQQQKGE 1753
Query: 444 LERTVHFYQKQVISYEKRGHDNWLA-ARTAERNLSDLRKENAHNKQKLTETELK 496
+E +QKQ++ +KR + A +R + + L KE ++K E K
Sbjct: 1754 IE-----WQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKK 1802
Score = 70.1 bits (170), Expect = 7e-12
Identities = 68/385 (17%), Positives = 176/385 (45%), Gaps = 26/385 (6%)
Query: 86 IEEKCKLLEK-FSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELED 144
++EKC + EK + ++ E S +E ++ EK R L+ ++LNR L +
Sbjct: 1792 LQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELN-VRKLQQELDQLNRDKLSLHN 1850
Query: 145 EILCLEKDLKEEKSKHSQQDELMADI--------------SKSIQSLEDESKSLKSQIAE 190
+I +++ L+E++ + E +A++ +K L E L+ I+E
Sbjct: 1851 DISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISE 1910
Query: 191 AKII---CKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKIT 247
C+ + +++++ +++ + EN + +FQ+ + + E S+L K+T
Sbjct: 1911 WANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVT 1970
Query: 248 FEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANL 307
++ + E+ L D+++ + + + +++ L+E+ ++LE ++ +
Sbjct: 1971 LKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSER 2030
Query: 308 DDPLKGALKKLIHAAKLNVSLKS-LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASL 366
+ L +L+ K S+++ RN + + + +K L E +K Q++ L
Sbjct: 2031 EQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALK---IQRSQL 2087
Query: 367 QSENIYFESENQKLQQK---LKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKI 423
+ + + EN +Q++ ++++ + E +L ++L + E +++++ ++
Sbjct: 2088 EKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLE 2147
Query: 424 SRATEGLETYRKLAKDLEEELERTV 448
R E + R L ++++E+ ++
Sbjct: 2148 RRQMEISDAMRTLKSEVKDEIRTSL 2172
Score = 62.8 bits (151), Expect = 1e-09
Identities = 104/451 (23%), Positives = 194/451 (43%), Gaps = 62/451 (13%)
Query: 85 LIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEA--RSLEATCEKLNRSNSEL 142
L ++K KL E+ +QK+ E E ED + E ++ A EKL +
Sbjct: 1536 LSKKKEKLTEELQKLQKDIEMAERN---EDHHLQVLKESEVLLQAKRAELEKLKSQVTSQ 1592
Query: 143 EDEILCLEKDLKEEKSK-HSQQDELM---ADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
+ E+ L++ L +K + H Q ++ AD+ ++++ E E + I E K + +
Sbjct: 1593 QQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEEL 1652
Query: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDS----KVH 254
+ + I + +QL T KQ ++E E + + +++K K ++ ++
Sbjct: 1653 SFQKGELNVQISE---RKTQL-TLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLE 1708
Query: 255 AEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGA 314
++ K H + ++ + K Q AVLEE LELE N + KG
Sbjct: 1709 NHELQGLKLQHDQRVS---ELEKTQVAVLEE------KLELE------NLQQISQQQKGE 1753
Query: 315 L---KKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHI-----KNLQTQQA-S 365
+ K+L+ K + + E ++ + K KE+L E K QT++ +
Sbjct: 1754 IEWQKQLLERDKREIERMTAESRALQSCVEC--LSKEKEDLQEKCDIWEKKLAQTKRVLA 1811
Query: 366 LQSENIYFESEN-QKLQQKL-KIMTEFYQEN--EMKLYRKLTVEENYRIEEEEKLSRVEE 421
EN E N +KL+ + K+ E Q N ++ L+ ++ + E+ E ++ ++E
Sbjct: 1812 AAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQE 1871
Query: 422 KISRATEGLETYRKLAKDLEEELERTVHF---------YQKQVISYEKRGHDNWLAARTA 472
+++ + L LAK ++ L T H QK + + R D T
Sbjct: 1872 ELANVQDHLN----LAK--QDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETK 1925
Query: 473 ERNLSDLRKENAHNKQKLTETELKFELLEKD 503
++ L L+ E NK KL + E+ F+ L+K+
Sbjct: 1926 QQQLQVLQNEIEENKLKLVQQEMMFQRLQKE 1956
Score = 62.0 bits (149), Expect = 2e-09
Identities = 93/473 (19%), Positives = 197/473 (41%), Gaps = 70/473 (14%)
Query: 75 EQKLGATLSGLIEEKCKL---LEKFSLIQKEYEGYEVESSLEDASFEK---AAAEEARSL 128
E+ L L + + K +L L+ L E +G +++ + EK A EE L
Sbjct: 1681 EENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLEL 1740
Query: 129 EATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQI 188
E + + E+E + LE+D +E E M S+++QS + K +
Sbjct: 1741 ENLQQISQQQKGEIEWQKQLLERDKREI--------ERMTAESRALQSCVECLSKEKEDL 1792
Query: 189 AEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITF 248
E I + K+++ +R +A A ENS+++ S+ + + + E+ +LN+ K++
Sbjct: 1793 QEKCDIWEK-KLAQTKRVLA---AAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSL 1848
Query: 249 EDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEED---TTDDDNLELEVN------- 298
+ +Q L +K + +L L ++D + ++D TT ++ L
Sbjct: 1849 HNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDI 1908
Query: 299 SQWENGAN---------------LDDPLKGALKKLIHA---------------AKLNVSL 328
S+W N L + ++ KL+ +KL S
Sbjct: 1909 SEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSK 1968
Query: 329 KSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMT 388
+L+ +++ + +L++ +++ + + + +LQ E + ES + L Q + ++
Sbjct: 1969 VTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLS 2028
Query: 389 EFYQENEMKLYRKLTVEEN----------YRIEEEEKLSRVEEKISRATEGLETYR-KLA 437
E Q+ K L +++ R + + + E++++ E L+ R +L
Sbjct: 2029 EREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLE 2088
Query: 438 KDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKL 490
K+L E+ + QK++ + E DN AR + L+ ++ E K+++
Sbjct: 2089 KNLLEQKQEN-SCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQM 2140
Score = 46.2 bits (108), Expect = 1e-04
Identities = 92/426 (21%), Positives = 176/426 (41%), Gaps = 66/426 (15%)
Query: 85 LIEEKCKLLEKFSLIQKEYEGYEVESS------LEDASFEKAAAEEAR---SLEATCEKL 135
L +EK LL++ + +++E + E+ + E A E A E+ SL+ T L
Sbjct: 642 LRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDL 701
Query: 136 NRSNSELEDEILCLEKD---LKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAK 192
+ +ELE + + + LKEE K ++ +L ++ LE E ++LK+ + +A+
Sbjct: 702 SAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQA--ELEKERQALKNALGKAQ 759
Query: 193 IICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKG---------EVSELNK 243
+ + + E A +K ++N+ L+ K V G V EL +
Sbjct: 760 FSEEKEQENSELHA-KLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRR 818
Query: 244 Q-KITFEDSKVHAE-----QVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELE- 296
+ K+ + +H+ + L D + + +D+A V E ++ L+ E
Sbjct: 819 KLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEK 878
Query: 297 -VNSQWENGANLDDPLKGALK--KLIHAAK----------LNVSLKSLEGERNHIIIQLS 343
Q E + L+ + K H A+ L +LKS+E + +QL
Sbjct: 879 LATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQ 938
Query: 344 EVDKTKEELTEHIKNLQ----TQQASLQSENIYFESENQKLQQ------KLKIMTEFYQE 393
E D+ KE + ++ L+ + A Q + + E +KL++ KL +
Sbjct: 939 EADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAK 998
Query: 394 NEMK----LYRKLTVEENYRIEEEEKLSR----VEEKISRATEGLETYRKLAKDLEE--- 442
+++K K+ E ++E E+ SR ++RA +E + L + E
Sbjct: 999 DQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFR 1058
Query: 443 -ELERT 447
E+E+T
Sbjct: 1059 LEMEKT 1064
Score = 43.1 bits (100), Expect = 0.001
Identities = 90/416 (21%), Positives = 171/416 (41%), Gaps = 79/416 (18%)
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
+E+ LE+DL+++ + + + I++ + +KSLK + K C+ K
Sbjct: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLN 329
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEA-----------EVWKGEVSELNKQ-------- 244
+ +K E ++ +L Q+ A + E +E++K
Sbjct: 330 TKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIG 389
Query: 245 KITFEDSKVHAEQVLNDK---------------ENHIKTLTGHLPM--------MKDQAA 281
K ++ + E + D N L GH P+ K AA
Sbjct: 390 KSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAA 449
Query: 282 V--LEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGE----- 334
L E + + E ++ E L++ ++ LKK+ A K ++ K L G
Sbjct: 450 QTRLSELHDEIEKAEQQILRATEEFKQLEEAIQ--LKKISEAGK-DLLYKQLSGRLQLVN 506
Query: 335 --RNHIIIQLSEVDKTKEELT---EHIKNLQTQQASLQS---ENIYFESENQKLQQKLKI 386
R + +++K K+E+ + IK+LQ SL S ++ + +++ +Q+L I
Sbjct: 507 KLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDI 566
Query: 387 MTEFYQENEMKLYRKLTVEENYRI-EEEEKLSRVEEKISRATEGLETYRKLAKDLEEELE 445
M + YQ+ E +L L+ RI +E E++ +EE++ TEG + L+++LE
Sbjct: 567 MNKQYQQLESRLDEILS-----RIAKETEEIKDLEEQL---TEGQIAANEA---LKKDLE 615
Query: 446 RTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLE 501
+ Q+ + + + + A A+ LR E Q+LTE E + + LE
Sbjct: 616 GVISGLQEYLGTIKGQ-------ATQAQNECRKLRDEKETLLQRLTEVEQERDQLE 664
Score = 37.0 bits (84), Expect = 0.070
Identities = 71/355 (20%), Positives = 138/355 (38%), Gaps = 71/355 (20%)
Query: 142 LEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMS 201
LE+E+ LE ++ KSK ++ + A +S + +E+ ++ + E K + ++
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSL--ECEVE 1378
Query: 202 EERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLND 261
E R + Q QQ+ + G V L ++ E S H E ++++
Sbjct: 1379 ELHRTV-----------------QKRQQQKDFIDGNVESL-MTELEIEKSLKHHEDIVDE 1420
Query: 262 KENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHA 321
E KTL +++ +L E E E++ E N + A + L+
Sbjct: 1421 IECIEKTLLKRRSELREADRLLAE-------AESELSCTKEKTKNAVEKFTDAKRSLLQT 1473
Query: 322 AKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQ 381
+ LE + L + D+ L K+L+ Q
Sbjct: 1474 ES---DAEELERRAQETAVNLVKADQQLRSLQADAKDLE--------------------Q 1510
Query: 382 QKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLE 441
K+K QE +K K+ ++ + + LS+ +EK++ E +KL KD+E
Sbjct: 1511 HKIK------QEEILKEINKIVAAKD---SDFQCLSKKKEKLT------EELQKLQKDIE 1555
Query: 442 EELERTVHFYQ----KQVISYEKRGHDNWLAAR--TAERNLSDLRKENAHNKQKL 490
H Q +V+ KR L ++ + ++ ++ L ++ H K++L
Sbjct: 1556 MAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEEL 1610
Score = 36.2 bits (82), Expect = 0.12
Identities = 95/459 (20%), Positives = 196/459 (42%), Gaps = 58/459 (12%)
Query: 102 EYEGYEVE-SSLEDASFE-KAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSK 159
E+ E E S LED K+ E R + A+ + + EL I L L+E+KS
Sbjct: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDL---LQEKKSL 1373
Query: 160 HSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSE---ERRAIAIKDALNEN 216
+ +EL + K Q + +++S + E +I K+ K E + K L
Sbjct: 1374 ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIE-KSLKHHEDIVDEIECIEKTLLKRR 1432
Query: 217 SQLQTSHKQLFQQEAEV------WKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLT 270
S+L+ + + L + E+E+ K V + K + ++ AE++ + L
Sbjct: 1433 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 1492
Query: 271 ---GHLPMMKDQAAVLEEDTTDDDNLELEVN-------SQWENGANLDDPLKGALKKL-- 318
L ++ A LE+ + + E+N S ++ + + L L+KL
Sbjct: 1493 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQK 1552
Query: 319 -IHAAKLNVSLKSLEGERNHIIIQL--SEVDKTKEELTEHIKNLQT--QQASLQSENIY- 372
I A+ N + + +++Q +E++K K ++T + + +Q + E ++
Sbjct: 1553 DIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHL 1612
Query: 373 ----FESENQKLQQKLKI-MTEFYQE-NEMKLYRKLTVEENYR--------IEEEEKLSR 418
LQ+ L++ TE ++ N ++ + L E +++ E + +L+
Sbjct: 1613 LQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTL 1672
Query: 419 VEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRG----HDNWLA--ARTA 472
++++I + E L+ + + EL+ + Q + ++E +G HD ++ +T
Sbjct: 1673 IKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLE--NHELQGLKLQHDQRVSELEKTQ 1730
Query: 473 ERNLSD-LRKENAH--NKQKLTETELKFELLEKDPNALD 508
L + L EN ++Q+ E E + +LLE+D ++
Sbjct: 1731 VAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE 1769
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 73.6 bits (179), Expect = 7e-13
Identities = 109/444 (24%), Positives = 189/444 (42%), Gaps = 60/444 (13%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEI 146
EEK K L K Q+ + S LE+ K + + LE KL+ ++L+D+I
Sbjct: 1019 EEKAKNLAKIRNKQEV-----MISDLEERL--KKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 147 LCLEKDLKEEKSKHSQQDELMADISKSIQSLEDES----------KSLKSQIAEAKIICK 196
L+ + E K + ++++E ++ ++ +DE+ + L++QIAE + +
Sbjct: 1072 AELQAQIDELKLQLAKKEE---ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128
Query: 197 TFKMSEERRAIAIKDALNENSQLQTSHKQLF-----QQEAEVWKG-EVSELNKQKITFED 250
+ K S + +D E L+T + QQE + EV+EL +K E+
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL--KKALEEE 1186
Query: 251 SKVHAEQVLNDKENH---IKTLTGHLPMMKDQAAVLEEDT----TDDDNLELEVNSQWEN 303
+K H Q+ + ++ H ++ L+ L K A LE++ TD+ L EV +
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246
Query: 304 GANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQ 363
A + +K + A + K EG+R + E+ + +L + N+ T
Sbjct: 1247 KAESEHK-----RKKLDAQVQELHAKVSEGDRLRV-----ELAEKASKLQNELDNVSTLL 1296
Query: 364 ASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKI 423
+ + I F + L+ +L+ E QE + KL + R EEEK S E++
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQ---KLNLSSRIRQLEEEKNSLQEQQ- 1352
Query: 424 SRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKEN 483
E E RK LE+ V Q Q+ +K+ D+ + E L K+
Sbjct: 1353 ----EEEEEARK-------NLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 484 AHNKQKLTETELKFELLEKDPNAL 507
Q+L E L ++ LEK N L
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRL 1425
Score = 70.5 bits (171), Expect = 6e-12
Identities = 103/477 (21%), Positives = 201/477 (42%), Gaps = 50/477 (10%)
Query: 76 QKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDAS-----FEKAAAEEARSLEA 130
Q+L A +S + +L EK S +Q E + V + LE+A F K AA L+
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDN--VSTLLEEAEKKGIKFAKDAASLESQLQD 1319
Query: 131 TCEKLN---RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQ 187
T E L R L I LE++ + + +++E ++ K + +L+ + K +
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK 1379
Query: 188 IAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVS-ELNKQKI 246
+ + T + EE + +KDA + +L+ K L + E K + EL+ +
Sbjct: 1380 VDDD---LGTIESLEEAKKKLLKDAEALSQRLE--EKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 247 TFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGAN 306
+ H QV ++ E K L K +A E+ D E E + +
Sbjct: 1435 DLD----HQRQVASNLEKKQKKFDQLLAEEKSISARYAEER---DRAEAEAREKETKALS 1487
Query: 307 LDDPLKGALKKLIHAAKLNVSLKS----LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ 362
L L+ AL+ + N L++ L ++ + + E++K+K L + ++ ++TQ
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Query: 363 QASLQSENIYFESENQKLQQKLKIMTEFYQ----------ENEMKLYRKLTVEENYRIEE 412
L+ E E +L+ ++ M ++ E + +L K E +E+
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607
Query: 413 EEKLSRV----EEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKR------G 462
E K + ++K+ + LE + A +E+ + + Q Q+ Y++
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667
Query: 463 HDNWLA-ARTAERNLSDLRKENAHNKQKLTETE--LKFELLEKDPNALDVSNTAFGR 516
D A ++ +E+ L L E +++L +E + E+D A +++N+A G+
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGK 1724
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/403 (23%), Positives = 186/403 (46%), Gaps = 43/403 (10%)
Query: 107 EVESSLEDASFEKAAAEE------ARSLEATCEKLNRSN--SELEDEILCLEKDLKEEKS 158
E+++ +++ + A EE AR + T K N EL+ +I L++D + EK+
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 159 KHSQQDELMADISKSIQSLEDESK-SLKSQIAEAKIICKTFKMSEERRAIAIKDALNENS 217
++ ++ D+S+ +++L+ E + +L + A+ ++ K + E + ++ N +
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEA 1192
Query: 218 QLQ-------TSHKQLFQQ--EAEVWKGEVSELNKQKITFEDSKVHAE-----QVLNDKE 263
Q+Q T+ ++L +Q +A+ +K + E NKQ + ++ ++ E QV + E
Sbjct: 1193 QIQDMRQRHATALEELSEQLEQAKRFKANL-EKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 264 NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVN---SQWENGA-NLDDPLKGALKKLI 319
+ K L Q L ++ D L +E+ S+ +N N+ L+ A KK I
Sbjct: 1252 HKRKKLDA-------QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304
Query: 320 HAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQK 379
AK SL+S + + L E + K L+ I+ L+ ++ SLQ + E +
Sbjct: 1305 KFAKDAASLESQLQDTQEL---LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361
Query: 380 LQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKD 439
L++++ + + + K+ L E+ +++ L E R E Y KL K
Sbjct: 1362 LEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT 1421
Query: 440 ---LEEEL-ERTVHF-YQKQVISYEKRGHDNWLAARTAERNLS 477
L++EL + TV +Q+QV S ++ + E+++S
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS 1464
Score = 64.7 bits (156), Expect = 3e-10
Identities = 98/485 (20%), Positives = 201/485 (41%), Gaps = 68/485 (14%)
Query: 59 LWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVE-SSLEDASF 117
L+ +R+RL ++Q+L L L + E+ ++Q E + + LE+
Sbjct: 902 LFAEAEEMRARL-AAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 118 EKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSL 177
E+ A + LE + ++E+EIL LE ++ SK ++ +LM
Sbjct: 961 EEEGARQKLQLEKVTAEAKIK--KMEEEILLLE----DQNSKFIKEKKLM---------- 1004
Query: 178 EDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGE 237
ED SQ+AE + K ++ + I D L E + + +Q ++ GE
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISD-LEERLKKEEKTRQELEKAKRKLDGE 1063
Query: 238 VSELNKQKITFEDSKVHAEQVLNDKENHI---------KTL--TGHLPMMKDQAAVLEED 286
++L Q + + L KE + +TL L ++++ A + E
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 287 TTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEV- 345
D ++ + N + +L + L+ +L + + L +R + +L +
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 346 -DKTK-----------------EELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIM 387
++TK EEL+E ++ + +A+L+ E++N++L ++K++
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL 1243
Query: 388 TEFYQENEMK----------LYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYR--- 434
+ E+E K L+ K++ + R+E EK S+++ ++ + LE
Sbjct: 1244 QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKG 1303
Query: 435 -KLAKD---LEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKL 490
K AKD LE +L+ T Q++ + +K + + E+N ++E +K
Sbjct: 1304 IKFAKDAASLESQLQDTQELLQEE--TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361
Query: 491 TETEL 495
E ++
Sbjct: 1362 LEKQV 1366
Score = 63.5 bits (153), Expect = 7e-10
Identities = 110/493 (22%), Positives = 206/493 (41%), Gaps = 57/493 (11%)
Query: 60 WRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESS--LEDASF 117
WR F V+ L V R+++ L EE K+ EK + ++ E E E + LE+ +
Sbjct: 835 WRVFTKVKPLLQVTRQEE---ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI 891
Query: 118 EKAAAEEARSLEATCE----KLNRSNSELEDEILCLEKDLKEEKSKH----SQQDELMAD 169
+ L A E +L ELE+ + LE ++EE+ ++ +++ ++ A
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951
Query: 170 ISKSIQSLEDESKS-----LKSQIAEAKI--ICKTFKMSEERRAIAIKDALNENSQLQTS 222
I + L++E + L+ AEAKI + + + E++ + IK+ ++
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 223 HKQLFQQEAEVWKGEVSELNKQKITFEDSKVH---AEQVLNDKENHIKTLTGHLPMMKDQ 279
QL ++E E K NKQ++ D + E+ + E + L G ++DQ
Sbjct: 1012 SSQLAEEE-EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 280 AAVLEEDTTDDDNLELEVNSQWENGA---------NLDDPLKGALKKLIHAAKLNVSLKS 330
A L+ D+ L+L + GA + ++ LK + A+L +S
Sbjct: 1071 IAELQAQ-IDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129
Query: 331 LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ-------QASLQSENIYFESENQKLQQK 383
+ RN + +K K +L+E ++ L+T+ A+ Q E E +L++
Sbjct: 1130 EKASRN-------KAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182
Query: 384 LKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYR-------KL 436
L+ T+ ++ + ++ E+ E+ R + + + +GLET K+
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1242
Query: 437 AKDLEEELERTVHFYQKQVIS-YEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETEL 495
+ ++ E E QV + K + L AE+ S L+ E + L E E
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK-ASKLQNELDNVSTLLEEAEK 1301
Query: 496 KFELLEKDPNALD 508
K KD +L+
Sbjct: 1302 KGIKFAKDAASLE 1314
Score = 62.0 bits (149), Expect = 2e-09
Identities = 92/408 (22%), Positives = 176/408 (43%), Gaps = 59/408 (14%)
Query: 123 EEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESK 182
E+ +E E++ R + +L +E L + L+ E ++ +E+ A ++ Q LE+
Sbjct: 866 EKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILH 925
Query: 183 SLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELN 242
L+S++ E EER I NE ++Q +H Q +++ + +G +L
Sbjct: 926 DLESRVEE----------EEERNQI----LQNEKKKMQ-AHIQDLEEQLDEEEGARQKLQ 970
Query: 243 KQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWE 302
+K+T E E+ + E+ +M+D+ A +++ E
Sbjct: 971 LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEE----------E 1020
Query: 303 NGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ 362
NL K K+ + + L LK E R E++K K +L +LQ Q
Sbjct: 1021 KAKNL---AKIRNKQEVMISDLEERLKKEEKTR-------QELEKAKRKLDGETTDLQDQ 1070
Query: 363 QASLQSE----NIYFESENQKLQQKLKIMTE--FYQENEMKLYRKL--TVEENYRIEEEE 414
A LQ++ + + ++LQ L + ++ N +K+ R+L + E E E
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 415 KLSR--VEEKISRATEGLETYRKLAKDLEEELERT-----VHFYQKQVISYEKRGHDNWL 467
K SR E++ +E LE L +LE+ L+ T + ++Q ++ K+ +
Sbjct: 1131 KASRNKAEKQKRDLSEELEA---LKTELEDTLDTTAAQQELRTKREQEVAELKKALEE-- 1185
Query: 468 AARTAERNLSDLRKENAHNKQKLT---ETELKFEL-LEKDPNALDVSN 511
+ E + D+R+ +A ++L+ E +F+ LEK+ L+ N
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1233
Score = 35.8 bits (81), Expect = 0.16
Identities = 44/186 (23%), Positives = 82/186 (44%), Gaps = 28/186 (15%)
Query: 83 SGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKA-----------AAEE--ARSLE 129
S L++EK +L + + +++E E + L + F K AAE A+ +
Sbjct: 1725 SALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSD 1784
Query: 130 ATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIA 189
++L R N EL+ ++ LE +K + + L A I + + LE E+ K + A
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFK--ATISALEAKIGQLEEQLEQEA---KERAA 1839
Query: 190 EAKIICKTFKM---------SEERRAIAIKDALNE-NSQLQTSHKQLFQQEAEVWKGEVS 239
K++ +T K E R A K+ + + N++++ +QL + E E + S
Sbjct: 1840 ANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899
Query: 240 ELNKQK 245
Q+
Sbjct: 1900 RRKLQR 1905
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 73.2 bits (178), Expect = 9e-13
Identities = 105/459 (22%), Positives = 208/459 (45%), Gaps = 68/459 (14%)
Query: 55 VLLFLW--RSFRSVRS----RLY-----VGREQKLGATLSGLIEEKCKLLEKFSLIQKEY 103
++L W R+F +V++ RL+ + + ++G ++GL EE C L+K +L + E+
Sbjct: 823 LILIQWNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLKEE-CAQLQK-ALEKSEF 880
Query: 104 EGYEVESSLEDASFEK--------AAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKE 155
+ E+++ + EK A E ++E CE L +S +LE + KE
Sbjct: 881 QREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARV-------KE 933
Query: 156 EKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNE 215
+ +++E+ ++++ + LEDE LK +I + + + K +E+R
Sbjct: 934 LSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETM--LVKSEKEKRT--------- 982
Query: 216 NSQLQTSHK-QLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLP 274
T HK + +E E ++S+LN+ +++ L+ +E + +L+
Sbjct: 983 -----TEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLS---- 1033
Query: 275 MMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLN-VSLKSLEG 333
+A + E D ELE + E A ++ + L KL KLN S+++LE
Sbjct: 1034 ----KANLKLEQQVD----ELEGALEQERKARMN--CERELHKLEGNLKLNRESMENLES 1083
Query: 334 ERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKI--MTEFY 391
+ H+ +L + + ++ ++N + A LQ +++ + L++KL+ T
Sbjct: 1084 SQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAK 1143
Query: 392 QENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFY 451
E E + + N R+EE S + +I++ E ++KL +D+E E T+HF
Sbjct: 1144 MERERADLTQDLADLNERLEEVGGSSLAQLEITKKQE--TKFQKLHRDME---EATLHF- 1197
Query: 452 QKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKL 490
+ S +KR D+ NL ++++ +K L
Sbjct: 1198 ETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDL 1236
Score = 55.8 bits (133), Expect = 1e-07
Identities = 78/372 (20%), Positives = 163/372 (43%), Gaps = 37/372 (9%)
Query: 85 LIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARS-LEATCEKLNRSNSELE 143
L+E K +L K S +E E + + S + + EA+S +E T K
Sbjct: 1577 LLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKK------- 1629
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
+E+DL E + + S + +++ +KS+ L+ + K L+ Q+ ++ T S+
Sbjct: 1630 -----MEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDS-----TQLNSDL 1679
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDK- 262
+ +A+ A NS LQ+ + L + + +G L+++++ +++ N
Sbjct: 1680 KEQVAV--AERRNSLLQSELEDLRSLQEQTERGR--RLSEEELLEATERINLFYTQNTSL 1735
Query: 263 ENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAA 322
+ K L + M+ +A EE + N E + ANL + LK KK A
Sbjct: 1736 LSQKKKLEADVARMQKEA---EEVVQECQNAEEKAKKAAIEAANLSEELK---KKQDTIA 1789
Query: 323 KLNVSLKSLEGERNHIIIQLSEVD--------KTKEELTEHIKNLQTQQASLQSENIYFE 374
L + +++E + +L+E + K ++L ++ L+ + + +
Sbjct: 1790 HLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQ 1849
Query: 375 SENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYR 434
++L++ +K +T +E++ L R T + +++ + +VE ++A + L Y+
Sbjct: 1850 RGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYK 1909
Query: 435 KLAKDLEEELER 446
K +L E ER
Sbjct: 1910 KQQHELNEVKER 1921
Score = 55.1 bits (131), Expect = 2e-07
Identities = 90/419 (21%), Positives = 179/419 (42%), Gaps = 66/419 (15%)
Query: 85 LIEEKCKLLEKFS-LIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELE 143
L E L E+ S L + EG + + +E +K EE ++ T E+ + E
Sbjct: 1510 LRRENKNLQEEISNLTNQVREGTKNLTEMEKV--KKLIEEEKTEVQVTLEETEGALERNE 1567
Query: 144 DEILCLEKDLKEEKS----KHSQQDELMADISKSIQ--------SLEDESKS------LK 185
+IL + +L E K+ K S++DE + + + Q SL+ E+KS LK
Sbjct: 1568 SKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLK 1627
Query: 186 SQIAE------AKIICKTFKMSEERRA-----IAIKDA---LNENSQLQTSHKQ---LFQ 228
++ E ++ C ++SE ++ I IKD L++++QL + K+ + +
Sbjct: 1628 KKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAE 1687
Query: 229 QEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTT 288
+ + + E+ +L + E + +E+ L + I + Q LE D
Sbjct: 1688 RRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVA 1747
Query: 289 DDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKT 348
EV + +N + A K I AA L+ LK + H+ ++T
Sbjct: 1748 RMQKEAEEVVQECQNAE------EKAKKAAIEAANLSEELKKKQDTIAHL-------ERT 1794
Query: 349 KEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEEN- 407
+E + + I +LQ + A ++E + +++Q+ + E E E ++ R +
Sbjct: 1795 RENMEQTITDLQKRLA--EAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGA 1852
Query: 408 -----------YRIEEEEK-LSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQ 454
Y+ EE++K LSR++ ++ + ++ Y++ + E + + + Y+KQ
Sbjct: 1853 RRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQ 1911
Score = 54.7 bits (130), Expect = 3e-07
Identities = 86/460 (18%), Positives = 181/460 (39%), Gaps = 73/460 (15%)
Query: 77 KLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAA-AEEARSLEATCEKL 135
K+ + L +K KL + + E E E+ + S EK+ + L EK
Sbjct: 1277 KVTQLANDLAAQKTKLWSESGEFLRRLE--EKEALINQLSREKSNFTRQIEDLRGQLEKE 1334
Query: 136 NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSI--------------------- 174
+S S L + ++D + ++ ++ E+ A++ +++
Sbjct: 1335 TKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQR 1394
Query: 175 -QSLEDESKSLKSQI---AEAKIICKTFKMSEERRA----IAIKDALNENSQLQTSHKQL 226
+ LED K L ++ AEA + S ER + + DAL++ +++++ +L
Sbjct: 1395 TEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARL 1454
Query: 227 FQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEED 286
Q++ + K K + ++ +L+ + ++ L+ L +K+ EE
Sbjct: 1455 DQKQLQSGKALADWKQKHE--------ESQALLDASQKEVQALSTELLKLKN---TYEES 1503
Query: 287 TTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVD 346
+ L E + E +NL + ++ K L K+ K +E E+ + + L E +
Sbjct: 1504 IVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVK---KLIEEEKTEVQVTLEETE 1560
Query: 347 KTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEE 406
E +S+ ++F+ E + E E E KL K E
Sbjct: 1561 GALERN--------------ESKILHFQLE----------LLEAKAELERKLSEKDEEIE 1596
Query: 407 NYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEE---ELERTVHFYQKQVISYEKRGH 463
N+R +++ + ++ + + +L K +EE E+E + +QV K
Sbjct: 1597 NFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLG 1656
Query: 464 DNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKD 503
+ + + L D + N+ K+++ E + LL+ +
Sbjct: 1657 QLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSE 1696
Score = 43.1 bits (100), Expect = 0.001
Identities = 77/368 (20%), Positives = 142/368 (38%), Gaps = 65/368 (17%)
Query: 168 ADISKSIQSLEDESKSL-----KSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTS 222
+++ + + L++E L KS+ ++ K +++E+ + + QLQ
Sbjct: 855 SEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLIL--------QLQAE 906
Query: 223 HKQLFQQEAEV-WKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAA 281
+ L E + W L K KI E + + ++E LT ++D+
Sbjct: 907 QETLANVEEQCEW------LIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECF 960
Query: 282 VLEEDTTDDDNL----ELEVNSQWENGANLDDP---LKGALKKLIHAAKL-----NVSLK 329
L+++ D + + E E + NL + L + KL AAK+ +L
Sbjct: 961 ELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLD 1020
Query: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
L E +LS + K +L + + L+ + + E E KL+ LK+ E
Sbjct: 1021 DLHMEEE----KLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRE 1076
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVH 449
EN R L E ++E +LS++ K+ K L +L++TV
Sbjct: 1077 S-MENLESSQRHLAEELR---KKELELSQMNSKVENE-----------KGLVAQLQKTVK 1121
Query: 450 FYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTET--------------EL 495
Q Q+ +++ ER +DL ++ A ++L E E
Sbjct: 1122 ELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQET 1181
Query: 496 KFELLEKD 503
KF+ L +D
Sbjct: 1182 KFQKLHRD 1189
Score = 38.9 bits (89), Expect = 0.018
Identities = 53/211 (25%), Positives = 92/211 (43%), Gaps = 36/211 (17%)
Query: 83 SGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEA------RSLEATCEKLN 136
+ L+ +K KL + +QKE E E + +KAA E A + + T L
Sbjct: 1733 TSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLE 1792
Query: 137 RSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQI-------A 189
R+ +E I L+K L E ++Q LM K IQ LE + L+ ++ A
Sbjct: 1793 RTRENMEQTITDLQKRLAE-----AEQMALMGS-RKQIQKLESRVRELEGELEGEIRRSA 1846
Query: 190 EAK---------IICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGE--- 237
EA+ I T++ E+++ ++ + QL+ Q ++Q+ EV + +
Sbjct: 1847 EAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQLKV---QNYKQQVEVAETQANQ 1903
Query: 238 -VSELNKQKITFEDSKVHAEQVLNDKENHIK 267
+S+ KQ+ + K AE V + N +K
Sbjct: 1904 YLSKYKKQQHELNEVKERAE-VAESQVNKLK 1933
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 72.4 bits (176), Expect = 2e-12
Identities = 96/399 (24%), Positives = 179/399 (44%), Gaps = 66/399 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQK--EYEGYEVESSLEDASFEKAAAEEARSLEAT 131
+E++L A L+ L +E + +K + ++K E EG+ + ED E+AA +A +
Sbjct: 1088 KEEELQAALARLDDE---IAQKNNALKKIRELEGH-ISDLQEDLDSERAARNKAEKQKRD 1143
Query: 132 C-EKLNRSNSELED-----------------EILCLEKDLKEEKSKHSQQDELMADISKS 173
E+L +ELED E+ L+K L EE H Q + M K
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ--KH 1201
Query: 174 IQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV 233
Q++E+ ++ L+ Q AK K + E+ + L Q KQ + + +
Sbjct: 1202 AQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQA----KQEVEHKKKK 1256
Query: 234 WKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNL 293
+ +V EL + E ++ ++ +N ++++TG L + +A L +D
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---- 1312
Query: 294 ELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS--LKSLEGERNHIIIQLSEVDKTKEE 351
++SQ ++ L L+ ++ KLNVS L+ LE ERN + QL E + K+
Sbjct: 1313 ---LSSQLQDTQEL---LQEETRQ-----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 352 LTEHIKNLQTQQASLQSENIYF-------ESENQKLQQKLKIMTEFYQENEMKLYRKLTV 404
L HI L Q + + + F E ++ Q++++ +T+ Y+E + Y KL
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE-KAAAYDKL-- 1418
Query: 405 EENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEE 443
E+ +R+++++ L+ R+L +LE++
Sbjct: 1419 --------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Score = 65.1 bits (157), Expect = 2e-10
Identities = 100/453 (22%), Positives = 184/453 (40%), Gaps = 74/453 (16%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSL---EATCEKLNRSNSELE 143
E K K LE L+ + + S E E+ ++ +L E + L + ++ E
Sbjct: 977 EAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
I LE LK+E+ + ++L + ++ L++QIAE K+ + K EE
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM--QLAKKEEE 1091
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKE 263
+A A+ +E +Q + K++ + E G +S+L + + ++ AE+ D
Sbjct: 1092 LQA-ALARLDDEIAQKNNALKKIRELE-----GHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 264 NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAK 323
++ L L EDT D + E+ ++ E + LKK +
Sbjct: 1146 EELEALKTEL-----------EDTLDSTATQQELRAKREQEVTV-------LKKALDEET 1187
Query: 324 LNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK 383
+ + E + H + EELTE ++ + +A+L E EN L +
Sbjct: 1188 RSHEAQVQEMRQKHA--------QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 384 LKIMTEFYQENEMK----------LYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETY 433
L+++ + QE E K L K + E R E +K+ +++ ++ T L
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 434 R----KLAKD---LEEELERTVHFYQKQV------------ISYEKRGHDNWL-----AA 469
KLAKD L +L+ T Q++ + E+ + L A
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 470 RTAERNLSDLRKENAHNKQKLTETELKFELLEK 502
+ ER++S L + + +K+KL + E LE+
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Score = 55.1 bits (131), Expect = 2e-07
Identities = 102/491 (20%), Positives = 198/491 (40%), Gaps = 89/491 (18%)
Query: 91 KLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE---KLNRSNSELEDEIL 147
+LL + I +Y + E E A AR+LE E +L R+N L+ E+
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM- 1513
Query: 148 CLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI----------ICKT 197
+DL K D+ K++ LE ++L++Q+ E K +
Sbjct: 1514 ---EDLVSSKD----------DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 198 FKMSEERRAIAIK-----DALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKI------ 246
K+ E A+K D + Q + +QL Q++ ++ E+ + KQ+
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-QRQLHEYETELEDERKQRALAAAAK 1619
Query: 247 -----TFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD---------- 291
+D ++ A+ + +E IK L MKD LE+ D
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 292 ----NLELEVNSQWENGANLDDPLKGA-LKKLIHAAKLNVSL---KSLEGERNHIIIQLS 343
+LE ++ E+ A + K A L+K A +L SL +L+ E+ + +++
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 344 EVDKTKEE--------------LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
++++ EE T+ + L + A+ +S ES Q+L+++ K +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELER--- 446
E E + K ++ E K++++EE++ + + K K +++L+
Sbjct: 1800 KLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 447 TVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNA 506
V +K Y+++ + +R L + +E+ Q++ K L+++ +
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES----QRINANRRK---LQRELDE 1909
Query: 507 LDVSNTAFGRE 517
SN A GRE
Sbjct: 1910 ATESNEAMGRE 1920
Score = 44.3 bits (103), Expect = 4e-04
Identities = 71/367 (19%), Positives = 153/367 (41%), Gaps = 47/367 (12%)
Query: 86 IEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDE 145
+E++ K + +K+ EG + L+ S K E + L ++ ELED
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED- 1663
Query: 146 ILCLEKDLKEEKSKHSQQDELMA---DISKSIQSLEDESKSLKSQIAEAKIICKTFKMSE 202
+ +DE+ A + K +SLE + L+ +A A+ K + +
Sbjct: 1664 -------------ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 203 ERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDK 262
E A + +L+ + LQ ++L + +++L ++ E+ + + E +
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRL--------EARIAQLEEE---LEEEQGNMEAM---- 1755
Query: 263 ENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAA 322
+ ++ T + ++ A +++ ++ Q + + ++GA+K +
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK-----S 1810
Query: 323 KLNVSLKSLEGERNHIIIQLSE-VDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQ 381
K ++ +LE + I QL E V++ E K+L+ + L+ + E E +K+
Sbjct: 1811 KFKSTIAALEAK----IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMA 1865
Query: 382 QKLKIMTEFYQENEMKLYRKL--TVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKD 439
++ K E +L R+L EE+ RI + +++ ++ ATE E +
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR--KLQRELDEATESNEAMGREVNA 1923
Query: 440 LEEELER 446
L+ +L R
Sbjct: 1924 LKSKLRR 1930
Score = 38.9 bits (89), Expect = 0.018
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 12/173 (6%)
Query: 344 EVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLT 403
E+ KTKE + + + L+ ++ E LQ++L+ TE Y E E R
Sbjct: 860 ELQKTKERQ----QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915
Query: 404 VEENYRIEEEEKLSRVEEKISRATEGLETYRKLAK---DLEEELERTVHFYQKQVISYEK 460
++ E +R+EE+ R + +K+A+ DLEE+LE QK + EK
Sbjct: 916 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEK 973
Query: 461 RGHDNWLAARTAERNLSDLRKENAHNKQKLTE---TELKFELLEKDPNALDVS 510
+ + E + D + ++KL E ++L L E++ A +++
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 72.4 bits (176), Expect = 2e-12
Identities = 96/399 (24%), Positives = 179/399 (44%), Gaps = 66/399 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQK--EYEGYEVESSLEDASFEKAAAEEARSLEAT 131
+E++L A L+ L +E + +K + ++K E EG+ + ED E+AA +A +
Sbjct: 1095 KEEELQAALARLDDE---IAQKNNALKKIRELEGH-ISDLQEDLDSERAARNKAEKQKRD 1150
Query: 132 C-EKLNRSNSELED-----------------EILCLEKDLKEEKSKHSQQDELMADISKS 173
E+L +ELED E+ L+K L EE H Q + M K
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ--KH 1208
Query: 174 IQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV 233
Q++E+ ++ L+ Q AK K + E+ + L Q KQ + + +
Sbjct: 1209 AQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQA----KQEVEHKKKK 1263
Query: 234 WKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNL 293
+ +V EL + E ++ ++ +N ++++TG L + +A L +D
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---- 1319
Query: 294 ELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS--LKSLEGERNHIIIQLSEVDKTKEE 351
++SQ ++ L L+ ++ KLNVS L+ LE ERN + QL E + K+
Sbjct: 1320 ---LSSQLQDTQEL---LQEETRQ-----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 352 LTEHIKNLQTQQASLQSENIYF-------ESENQKLQQKLKIMTEFYQENEMKLYRKLTV 404
L HI L Q + + + F E ++ Q++++ +T+ Y+E + Y KL
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE-KAAAYDKL-- 1425
Query: 405 EENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEE 443
E+ +R+++++ L+ R+L +LE++
Sbjct: 1426 --------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Score = 65.1 bits (157), Expect = 2e-10
Identities = 100/453 (22%), Positives = 184/453 (40%), Gaps = 74/453 (16%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSL---EATCEKLNRSNSELE 143
E K K LE L+ + + S E E+ ++ +L E + L + ++ E
Sbjct: 984 EAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
I LE LK+E+ + ++L + ++ L++QIAE K+ + K EE
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM--QLAKKEEE 1098
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKE 263
+A A+ +E +Q + K++ + E G +S+L + + ++ AE+ D
Sbjct: 1099 LQA-ALARLDDEIAQKNNALKKIRELE-----GHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 264 NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAK 323
++ L L EDT D + E+ ++ E + LKK +
Sbjct: 1153 EELEALKTEL-----------EDTLDSTATQQELRAKREQEVTV-------LKKALDEET 1194
Query: 324 LNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK 383
+ + E + H + EELTE ++ + +A+L E EN L +
Sbjct: 1195 RSHEAQVQEMRQKHA--------QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 384 LKIMTEFYQENEMK----------LYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETY 433
L+++ + QE E K L K + E R E +K+ +++ ++ T L
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 434 R----KLAKD---LEEELERTVHFYQKQV------------ISYEKRGHDNWL-----AA 469
KLAKD L +L+ T Q++ + E+ + L A
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 470 RTAERNLSDLRKENAHNKQKLTETELKFELLEK 502
+ ER++S L + + +K+KL + E LE+
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Score = 55.1 bits (131), Expect = 2e-07
Identities = 102/491 (20%), Positives = 198/491 (40%), Gaps = 89/491 (18%)
Query: 91 KLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE---KLNRSNSELEDEIL 147
+LL + I +Y + E E A AR+LE E +L R+N L+ E+
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM- 1520
Query: 148 CLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI----------ICKT 197
+DL K D+ K++ LE ++L++Q+ E K +
Sbjct: 1521 ---EDLVSSKD----------DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 198 FKMSEERRAIAIK-----DALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKI------ 246
K+ E A+K D + Q + +QL Q++ ++ E+ + KQ+
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-QRQLHEYETELEDERKQRALAAAAK 1626
Query: 247 -----TFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD---------- 291
+D ++ A+ + +E IK L MKD LE+ D
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 292 ----NLELEVNSQWENGANLDDPLKGA-LKKLIHAAKLNVSL---KSLEGERNHIIIQLS 343
+LE ++ E+ A + K A L+K A +L SL +L+ E+ + +++
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 344 EVDKTKEE--------------LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
++++ EE T+ + L + A+ +S ES Q+L+++ K +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELER--- 446
E E + K ++ E K++++EE++ + + K K +++L+
Sbjct: 1807 KLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 447 TVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNA 506
V +K Y+++ + +R L + +E+ Q++ K L+++ +
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES----QRINANRRK---LQRELDE 1916
Query: 507 LDVSNTAFGRE 517
SN A GRE
Sbjct: 1917 ATESNEAMGRE 1927
Score = 44.3 bits (103), Expect = 4e-04
Identities = 71/367 (19%), Positives = 153/367 (41%), Gaps = 47/367 (12%)
Query: 86 IEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDE 145
+E++ K + +K+ EG + L+ S K E + L ++ ELED
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED- 1670
Query: 146 ILCLEKDLKEEKSKHSQQDELMA---DISKSIQSLEDESKSLKSQIAEAKIICKTFKMSE 202
+ +DE+ A + K +SLE + L+ +A A+ K + +
Sbjct: 1671 -------------ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 203 ERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDK 262
E A + +L+ + LQ ++L + +++L ++ E+ + + E +
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRL--------EARIAQLEEE---LEEEQGNMEAM---- 1762
Query: 263 ENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAA 322
+ ++ T + ++ A +++ ++ Q + + ++GA+K +
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK-----S 1817
Query: 323 KLNVSLKSLEGERNHIIIQLSE-VDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQ 381
K ++ +LE + I QL E V++ E K+L+ + L+ + E E +K+
Sbjct: 1818 KFKSTIAALEAK----IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMA 1872
Query: 382 QKLKIMTEFYQENEMKLYRKL--TVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKD 439
++ K E +L R+L EE+ RI + +++ ++ ATE E +
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR--KLQRELDEATESNEAMGREVNA 1930
Query: 440 LEEELER 446
L+ +L R
Sbjct: 1931 LKSKLRR 1937
Score = 38.9 bits (89), Expect = 0.018
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 12/173 (6%)
Query: 344 EVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLT 403
E+ KTKE + + + L+ ++ E LQ++L+ TE Y E E R
Sbjct: 867 ELQKTKERQ----QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922
Query: 404 VEENYRIEEEEKLSRVEEKISRATEGLETYRKLAK---DLEEELERTVHFYQKQVISYEK 460
++ E +R+EE+ R + +K+A+ DLEE+LE QK + EK
Sbjct: 923 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEK 980
Query: 461 RGHDNWLAARTAERNLSDLRKENAHNKQKLTE---TELKFELLEKDPNALDVS 510
+ + E + D + ++KL E ++L L E++ A +++
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 72.4 bits (176), Expect = 2e-12
Identities = 96/399 (24%), Positives = 179/399 (44%), Gaps = 66/399 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQK--EYEGYEVESSLEDASFEKAAAEEARSLEAT 131
+E++L A L+ L +E + +K + ++K E EG+ + ED E+AA +A +
Sbjct: 1095 KEEELQAALARLDDE---IAQKNNALKKIRELEGH-ISDLQEDLDSERAARNKAEKQKRD 1150
Query: 132 C-EKLNRSNSELED-----------------EILCLEKDLKEEKSKHSQQDELMADISKS 173
E+L +ELED E+ L+K L EE H Q + M K
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ--KH 1208
Query: 174 IQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV 233
Q++E+ ++ L+ Q AK K + E+ + L Q KQ + + +
Sbjct: 1209 AQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQA----KQEVEHKKKK 1263
Query: 234 WKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNL 293
+ +V EL + E ++ ++ +N ++++TG L + +A L +D
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---- 1319
Query: 294 ELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS--LKSLEGERNHIIIQLSEVDKTKEE 351
++SQ ++ L L+ ++ KLNVS L+ LE ERN + QL E + K+
Sbjct: 1320 ---LSSQLQDTQEL---LQEETRQ-----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1368
Query: 352 LTEHIKNLQTQQASLQSENIYF-------ESENQKLQQKLKIMTEFYQENEMKLYRKLTV 404
L HI L Q + + + F E ++ Q++++ +T+ Y+E + Y KL
Sbjct: 1369 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE-KAAAYDKL-- 1425
Query: 405 EENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEE 443
E+ +R+++++ L+ R+L +LE++
Sbjct: 1426 --------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Score = 65.1 bits (157), Expect = 2e-10
Identities = 100/453 (22%), Positives = 184/453 (40%), Gaps = 74/453 (16%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSL---EATCEKLNRSNSELE 143
E K K LE L+ + + S E E+ ++ +L E + L + ++ E
Sbjct: 984 EAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
I LE LK+E+ + ++L + ++ L++QIAE K+ + K EE
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM--QLAKKEEE 1098
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKE 263
+A A+ +E +Q + K++ + E G +S+L + + ++ AE+ D
Sbjct: 1099 LQA-ALARLDDEIAQKNNALKKIRELE-----GHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 264 NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAK 323
++ L L EDT D + E+ ++ E + LKK +
Sbjct: 1153 EELEALKTEL-----------EDTLDSTATQQELRAKREQEVTV-------LKKALDEET 1194
Query: 324 LNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK 383
+ + E + H + EELTE ++ + +A+L E EN L +
Sbjct: 1195 RSHEAQVQEMRQKHA--------QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 384 LKIMTEFYQENEMK----------LYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETY 433
L+++ + QE E K L K + E R E +K+ +++ ++ T L
Sbjct: 1247 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 434 R----KLAKD---LEEELERTVHFYQKQV------------ISYEKRGHDNWL-----AA 469
KLAKD L +L+ T Q++ + E+ + L A
Sbjct: 1307 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Query: 470 RTAERNLSDLRKENAHNKQKLTETELKFELLEK 502
+ ER++S L + + +K+KL + E LE+
Sbjct: 1367 QNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Score = 58.9 bits (141), Expect = 2e-08
Identities = 106/507 (20%), Positives = 203/507 (40%), Gaps = 89/507 (17%)
Query: 91 KLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE---KLNRSNSELEDEIL 147
+LL + I +Y + E E A AR+LE E +L R+N L+ E+
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM- 1520
Query: 148 CLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI----------ICKT 197
+DL K D+ K++ LE ++L++Q+ E K +
Sbjct: 1521 ---EDLVSSKD----------DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1567
Query: 198 FKMSEERRAIAIK-----DALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKI------ 246
K+ E A+K D + Q + +QL Q++ ++ E+ + KQ+
Sbjct: 1568 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-QRQLHEYETELEDERKQRALAAAAK 1626
Query: 247 -----TFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD---------- 291
+D ++ A+ + +E IK L MKD LE+ D
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686
Query: 292 ----NLELEVNSQWENGANLDDPLKGA-LKKLIHAAKLNVSL---KSLEGERNHIIIQLS 343
+LE ++ E+ A + K A L+K A +L SL +L+ E+ + +++
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746
Query: 344 EVDKTKEE--------------LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
++++ EE T+ + L + A+ +S ES Q+L+++ K +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELER--- 446
E E + K ++ E K++++EE++ + + K K +++L+
Sbjct: 1807 KLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1863
Query: 447 TVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNA 506
V +K Y+++ + +R L + +E+ Q++ K L+++ +
Sbjct: 1864 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES----QRINANRRK---LQRELDE 1916
Query: 507 LDVSNTAFGREHSPCSPSPLGRPSSET 533
SN A GRE + G P ET
Sbjct: 1917 ATESNEAMGREVNALKSKLRGPPPQET 1943
Score = 42.4 bits (98), Expect = 0.002
Identities = 65/328 (19%), Positives = 133/328 (40%), Gaps = 44/328 (13%)
Query: 86 IEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDE 145
+E++ K + +K+ EG + L+ S K E + L ++ ELED
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED- 1670
Query: 146 ILCLEKDLKEEKSKHSQQDELMA---DISKSIQSLEDESKSLKSQIAEAKIICKTFKMSE 202
+ +DE+ A + K +SLE + L+ +A A+ K + +
Sbjct: 1671 -------------ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 203 ERRAIAIKDALNENSQLQTSHKQL------FQQEAEVWKGEVSELNKQKITFEDSKVHAE 256
E A + +L+ + LQ ++L ++E E +G + ++ + + AE
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR---VRKATQQAE 1774
Query: 257 QVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENG--------ANLD 308
Q+ N+ T + + +E + +E V S++++ A L+
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1834
Query: 309 DPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTE-------HIKNLQT 361
+ ++ ++ A K SLK + + I++Q+ + K E+ E +K L+
Sbjct: 1835 EQVEQEAREKQAATK---SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 362 QQASLQSENIYFESENQKLQQKLKIMTE 389
Q + E+ + +KLQ++L TE
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATE 1919
Score = 38.9 bits (89), Expect = 0.018
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 12/173 (6%)
Query: 344 EVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLT 403
E+ KTKE + + + L+ ++ E LQ++L+ TE Y E E R
Sbjct: 867 ELQKTKERQ----QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 922
Query: 404 VEENYRIEEEEKLSRVEEKISRATEGLETYRKLAK---DLEEELERTVHFYQKQVISYEK 460
++ E +R+EE+ R + +K+A+ DLEE+LE QK + EK
Sbjct: 923 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEK 980
Query: 461 RGHDNWLAARTAERNLSDLRKENAHNKQKLTE---TELKFELLEKDPNALDVS 510
+ + E + D + ++KL E ++L L E++ A +++
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 72.4 bits (176), Expect = 2e-12
Identities = 96/399 (24%), Positives = 179/399 (44%), Gaps = 66/399 (16%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQK--EYEGYEVESSLEDASFEKAAAEEARSLEAT 131
+E++L A L+ L +E + +K + ++K E EG+ + ED E+AA +A +
Sbjct: 1088 KEEELQAALARLDDE---IAQKNNALKKIRELEGH-ISDLQEDLDSERAARNKAEKQKRD 1143
Query: 132 C-EKLNRSNSELED-----------------EILCLEKDLKEEKSKHSQQDELMADISKS 173
E+L +ELED E+ L+K L EE H Q + M K
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQ--KH 1201
Query: 174 IQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEV 233
Q++E+ ++ L+ Q AK K + E+ + L Q KQ + + +
Sbjct: 1202 AQAVEELTEQLE-QFKRAKANLDKNKQTLEKENADLAGELRVLGQA----KQEVEHKKKK 1256
Query: 234 WKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNL 293
+ +V EL + E ++ ++ +N ++++TG L + +A L +D
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS---- 1312
Query: 294 ELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS--LKSLEGERNHIIIQLSEVDKTKEE 351
++SQ ++ L L+ ++ KLNVS L+ LE ERN + QL E + K+
Sbjct: 1313 ---LSSQLQDTQEL---LQEETRQ-----KLNVSTKLRQLEEERNSLQDQLDEEMEAKQN 1361
Query: 352 LTEHIKNLQTQQASLQSENIYF-------ESENQKLQQKLKIMTEFYQENEMKLYRKLTV 404
L HI L Q + + + F E ++ Q++++ +T+ Y+E + Y KL
Sbjct: 1362 LERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE-KAAAYDKL-- 1418
Query: 405 EENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEE 443
E+ +R+++++ L+ R+L +LE++
Sbjct: 1419 --------EKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Score = 65.1 bits (157), Expect = 2e-10
Identities = 100/453 (22%), Positives = 184/453 (40%), Gaps = 74/453 (16%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSL---EATCEKLNRSNSELE 143
E K K LE L+ + + S E E+ ++ +L E + L + ++ E
Sbjct: 977 EAKIKKLEDEILVMDDQNN---KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEE 203
I LE LK+E+ + ++L + ++ L++QIAE K+ + K EE
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM--QLAKKEEE 1091
Query: 204 RRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKE 263
+A A+ +E +Q + K++ + E G +S+L + + ++ AE+ D
Sbjct: 1092 LQA-ALARLDDEIAQKNNALKKIRELE-----GHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 264 NHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAK 323
++ L L EDT D + E+ ++ E + LKK +
Sbjct: 1146 EELEALKTEL-----------EDTLDSTATQQELRAKREQEVTV-------LKKALDEET 1187
Query: 324 LNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK 383
+ + E + H + EELTE ++ + +A+L E EN L +
Sbjct: 1188 RSHEAQVQEMRQKHA--------QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 384 LKIMTEFYQENEMK----------LYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETY 433
L+++ + QE E K L K + E R E +K+ +++ ++ T L
Sbjct: 1240 LRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 434 R----KLAKD---LEEELERTVHFYQKQV------------ISYEKRGHDNWL-----AA 469
KLAKD L +L+ T Q++ + E+ + L A
Sbjct: 1300 EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Query: 470 RTAERNLSDLRKENAHNKQKLTETELKFELLEK 502
+ ER++S L + + +K+KL + E LE+
Sbjct: 1360 QNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Score = 58.9 bits (141), Expect = 2e-08
Identities = 106/507 (20%), Positives = 203/507 (40%), Gaps = 89/507 (17%)
Query: 91 KLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE---KLNRSNSELEDEIL 147
+LL + I +Y + E E A AR+LE E +L R+N L+ E+
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEM- 1513
Query: 148 CLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI----------ICKT 197
+DL K D+ K++ LE ++L++Q+ E K +
Sbjct: 1514 ---EDLVSSKD----------DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATED 1560
Query: 198 FKMSEERRAIAIK-----DALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKI------ 246
K+ E A+K D + Q + +QL Q++ ++ E+ + KQ+
Sbjct: 1561 AKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL-QRQLHEYETELEDERKQRALAAAAK 1619
Query: 247 -----TFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDD---------- 291
+D ++ A+ + +E IK L MKD LE+ D
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679
Query: 292 ----NLELEVNSQWENGANLDDPLKGA-LKKLIHAAKLNVSL---KSLEGERNHIIIQLS 343
+LE ++ E+ A + K A L+K A +L SL +L+ E+ + +++
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739
Query: 344 EVDKTKEE--------------LTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
++++ EE T+ + L + A+ +S ES Q+L+++ K +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799
Query: 390 FYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELER--- 446
E E + K ++ E K++++EE++ + + K K +++L+
Sbjct: 1800 KLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILL 1856
Query: 447 TVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNA 506
V +K Y+++ + +R L + +E+ Q++ K L+++ +
Sbjct: 1857 QVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES----QRINANRRK---LQRELDE 1909
Query: 507 LDVSNTAFGREHSPCSPSPLGRPSSET 533
SN A GRE + G P ET
Sbjct: 1910 ATESNEAMGREVNALKSKLRGPPPQET 1936
Score = 42.4 bits (98), Expect = 0.002
Identities = 65/328 (19%), Positives = 133/328 (40%), Gaps = 44/328 (13%)
Query: 86 IEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDE 145
+E++ K + +K+ EG + L+ S K E + L ++ ELED
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED- 1663
Query: 146 ILCLEKDLKEEKSKHSQQDELMA---DISKSIQSLEDESKSLKSQIAEAKIICKTFKMSE 202
+ +DE+ A + K +SLE + L+ +A A+ K + +
Sbjct: 1664 -------------ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 203 ERRAIAIKDALNENSQLQTSHKQL------FQQEAEVWKGEVSELNKQKITFEDSKVHAE 256
E A + +L+ + LQ ++L ++E E +G + ++ + + AE
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR---VRKATQQAE 1767
Query: 257 QVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENG--------ANLD 308
Q+ N+ T + + +E + +E V S++++ A L+
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLE 1827
Query: 309 DPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTE-------HIKNLQT 361
+ ++ ++ A K SLK + + I++Q+ + K E+ E +K L+
Sbjct: 1828 EQVEQEAREKQAATK---SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 362 QQASLQSENIYFESENQKLQQKLKIMTE 389
Q + E+ + +KLQ++L TE
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATE 1912
Score = 38.9 bits (89), Expect = 0.018
Identities = 42/173 (24%), Positives = 76/173 (43%), Gaps = 12/173 (6%)
Query: 344 EVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLT 403
E+ KTKE + + + L+ ++ E LQ++L+ TE Y E E R
Sbjct: 860 ELQKTKERQ----QKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAA 915
Query: 404 VEENYRIEEEEKLSRVEEKISRATEGLETYRKLAK---DLEEELERTVHFYQKQVISYEK 460
++ E +R+EE+ R + +K+A+ DLEE+LE QK + EK
Sbjct: 916 KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK--LQLEK 973
Query: 461 RGHDNWLAARTAERNLSDLRKENAHNKQKLTE---TELKFELLEKDPNALDVS 510
+ + E + D + ++KL E ++L L E++ A +++
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 71.6 bits (174), Expect = 3e-12
Identities = 94/436 (21%), Positives = 195/436 (44%), Gaps = 44/436 (10%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEI 146
EEK K L K ++ ++E + + LE+ + ++ + LE T KL +++L D+I
Sbjct: 1012 EEKSKSLAK---LKNKHEA--MITDLEERL--RREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 147 LCLEKDLKEEKSKHSQQDELMADISKSIQSLEDES----------KSLKSQIAEAKIICK 196
L+ + E K + ++++E ++ ++ +E+E+ + L+SQI+E + +
Sbjct: 1065 AELQAQIAELKMQLAKKEE---ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 1121
Query: 197 TFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEA---EVWKGEVSELNKQKITFED-SK 252
+ + S + +D E L+T + A E+ E+N K T E+ +K
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 253 VHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLK 312
H Q+ ++ H + + ++ A LE+ NLE + L + +K
Sbjct: 1182 THEAQIQEMRQKHSQAV-------EELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234
Query: 313 GALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIY 372
L+ K +E + + ++ +E ++ + EL + + LQ + ++
Sbjct: 1235 VLLQG---KGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 373 FESENQKLQQKLKIMTEFYQENEMKLYRKLTVEEN-YRIEEEEKLSRVEEKISRATEGLE 431
+S++ KL + + E++++ ++L EEN ++ KL +VE++ + E LE
Sbjct: 1292 SDSKSSKLTKDFSAL-----ESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE 1346
Query: 432 TYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLT 491
+ +LE+++ T+H QV +K+ D+ TAE L+K+ Q+
Sbjct: 1347 EEEEAKHNLEKQIA-TLH---AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 492 ETELKFELLEKDPNAL 507
E ++ LEK L
Sbjct: 1403 EKVAAYDKLEKTKTRL 1418
Score = 62.4 bits (150), Expect = 2e-09
Identities = 98/443 (22%), Positives = 179/443 (40%), Gaps = 50/443 (11%)
Query: 87 EEKCKLLEKFSLIQKEYEGYEVESSLEDASF--EKAAAE-EARSLEATCEKLNRSNSELE 143
+ C L +K QK+++ E A + E+ AE EAR E L R+ E
Sbjct: 1434 QSACNLEKK----QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAM 1489
Query: 144 DEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI---------- 193
++ LE+ K+ +++ D+ KS+ LE ++L+ Q+ E K
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 194 ICKTFKMSEERRAIAIK-----DALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITF 248
+ K+ E A+K D + Q + KQL +Q E+ + E+ + KQ+
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM-EAELEDERKQRSMA 1608
Query: 249 EDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLD 308
++ E L D E HI + + Q L+ D LD
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR-------------ELD 1655
Query: 309 DPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQS 368
D + L A + LKS+E E + +L+ ++ K + + L + A+
Sbjct: 1656 DTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSG 1715
Query: 369 ENIYFESENQKLQQKLKIMTEFYQENE--MKLYRKLTVEENYRIEEEEKLSRVE----EK 422
+ E ++L+ ++ + E +E + +L + N +I++ +E +K
Sbjct: 1716 KGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQK 1775
Query: 423 ISRATEGLETYRKLAKDLEEELERTVHF-YQKQVISYEKRGHDNWLAARTAERNLSDLRK 481
A + LE K K +E+E TV Y+ + + E + A+ E+ ++ ++
Sbjct: 1776 NENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAK------IAQLEEQLDNETKE 1829
Query: 482 ENAHNKQ-KLTETELKFELLEKD 503
A KQ + TE +LK LL+ D
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVD 1852
Score = 59.3 bits (142), Expect = 1e-08
Identities = 94/444 (21%), Positives = 177/444 (39%), Gaps = 97/444 (21%)
Query: 60 WRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEK 119
WR F V+ L V R+++ ++ KE E +V EK
Sbjct: 828 WRLFTKVKPLLQVSRQEE-------------------EMMAKEEELVKVR--------EK 860
Query: 120 AAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLED 179
A E R E + S+L E L L++ L+ E ++ +EL A ++ Q LE+
Sbjct: 861 QLAAENRLTE-----METLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE 915
Query: 180 ESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVS 239
L++++ E + C+ + +++ I++ L E + + S +Q Q E + ++
Sbjct: 916 ICHDLEARVEEEEERCQHLQAEKKKMQQNIQE-LEEQLEEEESARQKLQLEKVTTEAKLK 974
Query: 240 ELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNS 299
+L +++I ED L +++D+ A + T+++
Sbjct: 975 KLEEEQIILEDQNC--------------KLAKEKKLLEDRIAEFTTNLTEEE-------- 1012
Query: 300 QWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNL 359
E +L A K H A + + L E Q E++KT+ +L +L
Sbjct: 1013 --EKSKSL------AKLKNKHEAMITDLEERLRREEK----QRQELEKTRRKLEGDSTDL 1060
Query: 360 QTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRV 419
Q A LQ++ + + K +++L+ +E ++N + +K+ +
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEE--------AAQKNMAL---KKIREL 1109
Query: 420 EEKISRATEGLETYR-------KLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTA 472
E +IS E LE+ R K +DL EELE K ++ L + A
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEAL------------KTELEDTLDSTAA 1157
Query: 473 ERNLSDLRKENAHNKQKLTETELK 496
++ L R++ + +K E E K
Sbjct: 1158 QQELRSKREQEVNILKKTLEEEAK 1181
Score = 58.9 bits (141), Expect = 2e-08
Identities = 101/476 (21%), Positives = 185/476 (38%), Gaps = 68/476 (14%)
Query: 85 LIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRS-NSELE 143
L+ E+ + K++ + E E + S +A EEA +A E+LN+ +E+E
Sbjct: 1449 LLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL-EEAMEQKAELERLNKQFRTEME 1507
Query: 144 DEILCLE---KDLKE-EKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFK 199
D + + K + E EKSK + + ++ ++ ++ LEDE ++ + ++ + K
Sbjct: 1508 DLMSSKDDVGKSVHELEKSKRALEQQV-EEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566
Query: 200 MSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVL 259
ER D + Q + KQL +Q E+ + E+ + KQ+ ++ E L
Sbjct: 1567 AQFER------DLQGRDEQSEEKKKQLVRQVREM-EAELEDERKQRSMAVAARKKLEMDL 1619
Query: 260 NDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLI 319
D E HI + + Q L+ D LDD + L
Sbjct: 1620 KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR-------------ELDDTRASREEILA 1666
Query: 320 HAAKLNVSLKSLEGERNHIIIQLSEVDKTK-------EELTEHIKN-------------- 358
A + LKS+E E + +L+ ++ K +EL + I N
Sbjct: 1667 QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR 1726
Query: 359 -----------LQTQQASLQSENIYFESENQKLQQ---KLKIMTEFYQENEMKLYRKLTV 404
L+ +Q + + N + N ++ Q L + Q+NE +
Sbjct: 1727 LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQ 1786
Query: 405 EENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQ---KQVISYEKR 461
+ +++ +E V+ K + LE K+A+ LEE+L+ Q KQV EK+
Sbjct: 1787 NKELKVKLQEMEGTVKSKYKASITALEA--KIAQ-LEEQLDNETKERQAACKQVRRTEKK 1843
Query: 462 GHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGRE 517
D L RN + + +L + + + E E++ + S RE
Sbjct: 1844 LKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRE 1899
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 71.6 bits (174), Expect = 3e-12
Identities = 101/458 (22%), Positives = 191/458 (41%), Gaps = 54/458 (11%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCE 133
R ++ G S IE K +F ++++ E ++ A+ K A+ L +
Sbjct: 1150 RLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQID 1209
Query: 134 KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI 193
L R +LE K+ E K + M +SKS +LE ++L+ Q++EA+
Sbjct: 1210 NLQRVKQKLE-------KEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEAR- 1261
Query: 194 ICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKV 253
K E +R+++ + + S+LQT +L +Q E + VS+L++ K F
Sbjct: 1262 ----GKNEEIQRSLS--ELTTQKSRLQTEAGELSRQLEEK-ESIVSQLSRSKQAFTQQTE 1314
Query: 254 HAEQVLNDKENHIKTLTGH-LPMMKDQAAVLEEDTTDDDNLELEVN----------SQWE 302
++ L ++EN K H L + +L E ++ + E+ +QW
Sbjct: 1315 ELKRQL-EEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWR 1373
Query: 303 NGANLD-----DPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIK 357
D + L+ A KKL A +L S + +E + + + ++KTK+ L ++
Sbjct: 1374 TKYETDAIQRTEELEEAKKKL--AQRLQDSEEQVEA----VNAKCASLEKTKQRLQGEVE 1427
Query: 358 NLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLS 417
+L S + + + + L +E++ +L L + E L
Sbjct: 1428 DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTE----LF 1483
Query: 418 RVEEKISRATEGLETYRKLAKDLEEELE----------RTVHFYQKQVISYEKRGHDNWL 467
+++ A + LET ++ K+LE+E+ +T+H +K E D L
Sbjct: 1484 KLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQL 1543
Query: 468 AARTAERNLSDLRKENAHNKQKLTE--TELKFELLEKD 503
A AE L + + +LT+ +E+ ++ EKD
Sbjct: 1544 ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKD 1581
Score = 64.7 bits (156), Expect = 3e-10
Identities = 104/477 (21%), Positives = 194/477 (40%), Gaps = 54/477 (11%)
Query: 63 FRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAA 122
F ++ L +K AT+ ++ L K +KE E V E +
Sbjct: 834 FFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ 893
Query: 123 EEARSL---EATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLED 179
E+ +L E C++L ++ +LE +I KE + ++E+ A+++ + LED
Sbjct: 894 AESENLLDAEERCDQLIKAKFQLEAKI-------KEVTERAEDEEEINAELTAKKRKLED 946
Query: 180 ESKSLKSQIAEAKIIC------------KTFKMSEERRAI--AIKDALNENSQLQTSHKQ 225
E LK I + ++ K ++EE + I E LQ +H+Q
Sbjct: 947 ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 226 LFQQEAEVWKGEVSELNKQKITFE------DSKVHAEQVLN-DKENHIKTLTGHLPMMKD 278
+ + + +V+ LNK K E +S + E+ L D E + + L G L + ++
Sbjct: 1007 AL-DDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE 1065
Query: 279 QAAVLEEDTTD-DDNLE------LEVNSQWENGANLDDPLKGALKKL-IHAAKLNVSLKS 330
LE D D+ L+ ++ S+ E+ L + +K+L +L +++
Sbjct: 1066 SILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEA 1125
Query: 331 LEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEF 390
R Q S+ + EEL+E ++ ++ N E+E KL++ L+ T
Sbjct: 1126 ERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQ 1185
Query: 391 YQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHF 450
++ L +K E+ + L RV++K LE + K ++L ++
Sbjct: 1186 HEAMVAALRKKHADSVAELGEQIDNLQRVKQK-------LEKEKSEFKLEIDDLSSSMES 1238
Query: 451 YQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNAL 507
K + EK RT E LS+ R +N ++ L+E + L+ + L
Sbjct: 1239 VSKSKANLEK-------ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL 1288
Score = 54.3 bits (129), Expect = 4e-07
Identities = 81/408 (19%), Positives = 167/408 (40%), Gaps = 40/408 (9%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQK--EYEGYEVESSLEDASFEKAAAEEARSLEATC 132
EQ++ A L+ I E K + + +K E E +++ +LE+A EEA+ L
Sbjct: 1507 EQEI-ADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAE-AALEHEEAKILRIQL 1564
Query: 133 E------KLNRSNSELEDEILCLEKD-----------LKEEKSKHSQQDELMADISKSIQ 175
E +++R +E ++EI L+++ L E ++ L + +
Sbjct: 1565 ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN 1624
Query: 176 SLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWK 235
+E + Q AE ++ + + + + DAL L+ + ++ A + +
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLK-EQLAIVERRANLLQ 1683
Query: 236 GEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGH------------LPMMKDQAAVL 283
EV EL E ++ AEQ L D ++ L +M+ Q+ V
Sbjct: 1684 AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEV- 1742
Query: 284 EEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLS 343
E+ + D N E + + A + + LK H ++ +L+ + H + +
Sbjct: 1743 EDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Query: 344 EV-----DKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKL 398
++ K ++L I+ L+ + Q +N +K ++++K +T +E+ +
Sbjct: 1803 QLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNV 1862
Query: 399 YRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELER 446
R + + +++ + + EE +A L +RK +LEE ER
Sbjct: 1863 LRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Score = 48.9 bits (115), Expect = 2e-05
Identities = 74/359 (20%), Positives = 137/359 (38%), Gaps = 46/359 (12%)
Query: 107 EVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDEL 166
EV S E +K + +E NR +E + ++ LK+ +
Sbjct: 1605 EVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRG 1664
Query: 167 MADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQ- 225
D+ + + +E + L++++ E + T + +E R +A ++ L+ N ++Q H Q
Sbjct: 1665 QEDLKEQLAIVERRANLLQAEVEELRA---TLEQTERARKLAEQELLDSNERVQLLHTQN 1721
Query: 226 -------------LFQQEAEVWKGEVSELN---KQKITFEDSKVHAEQVLNDKENHIKTL 269
L Q ++EV N K K D+ + AE++ +++
Sbjct: 1722 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT----- 1776
Query: 270 TGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLK 329
+ HL MK E T D L+ Q LKG K++ KL ++
Sbjct: 1777 SAHLERMKKNL----EQTVKDLQHRLDEAEQLA--------LKGGKKQI---QKLETRIR 1821
Query: 330 SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTE 389
LE E + +E K + +K L Q + + + KLQ K+K
Sbjct: 1822 ELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKR 1881
Query: 390 FYQENEMKLYRKLTV--EENYRIEEEEKLSRVEE----KISRATEGLETYRKLAKDLEE 442
+E + + LT + + +EE E+ + + E K+ T + R + + EE
Sbjct: 1882 QAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
Score = 43.9 bits (102), Expect = 6e-04
Identities = 88/469 (18%), Positives = 200/469 (42%), Gaps = 68/469 (14%)
Query: 78 LGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARS-----LEATC 132
L TL+ + +EK K + +E G ++ ++ + EK A +EA L+A
Sbjct: 958 LELTLAKVEKEKHATENKVKNLTEELSG--LDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Query: 133 EK---LNRSNSELEDEILCLEKDLKEEKSKHSQQD----ELMADIS---KSIQSLEDESK 182
+K LN++ S+LE ++ LE L++EK + +L D+ +SI LE++ +
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 1075
Query: 183 SLKSQIAEAKI-ICKTFKMSEERRAIAIK------------DALNENSQLQTSHKQLFQQ 229
L ++ + C+ E+ + + ++ + L E + + + + ++
Sbjct: 1076 QLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEK 1135
Query: 230 EAEVWKGEVSELNKQ--------KITFEDSKVHAEQVLNDKENHIKTLTGHLPMMK---- 277
+ + E+ EL+++ E +K + L + + + H M+
Sbjct: 1136 QRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRK 1195
Query: 278 ---DQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHA-AKLNVSLKSLEG 333
D A L E + ++ ++ + D L +++ + + A L ++LE
Sbjct: 1196 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED 1255
Query: 334 ERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQE 393
+ + + E+ ++ ELT LQT+ L +++L++K I+++ +
Sbjct: 1256 QLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL----------SRQLEEKESIVSQLSRS 1305
Query: 394 NEMKLYRKLTVEENYRIEEEEKL-SRVEEKISRATEGLETYRKLAKDLEE---ELERTVH 449
+ + + T E ++EEE K + + + + + R+ ++ +E EL+R +
Sbjct: 1306 KQ--AFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1363
Query: 450 FYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFE 498
+V + + ++ RT E L + +K+ A Q+L ++E + E
Sbjct: 1364 KANSEVAQWRTK-YETDAIQRTEE--LEEAKKKLA---QRLQDSEEQVE 1406
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 71.6 bits (174), Expect = 3e-12
Identities = 140/669 (20%), Positives = 278/669 (41%), Gaps = 133/669 (19%)
Query: 80 ATLSGLIEEKCKLLEKF--SLIQKEYEGYEVESSLEDASFEKAAAEEARSL------EAT 131
A+L+ +E + ++L+K +L Q + EG +++S + + + AA+ + + EAT
Sbjct: 990 ASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEAT 1049
Query: 132 CE---------KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESK 182
E +L R+N+ L+ E L++ L+ ++++ + + K L++ +
Sbjct: 1050 MELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNT 1109
Query: 183 SLKSQIAEAKIICKTFKMSEERRAIAIKDAL--NENSQLQTSHKQLFQQEAEVWKGEVSE 240
+L++Q A+ ++ T +S + A+ + L N ++ +T ++ L +Q+ ++ +
Sbjct: 1110 TLQTQTAKLQVENST--LSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAYEAL 1167
Query: 241 LNKQKI--TFEDSKVHAEQVLNDKENHIKTLTGHLP------------MMKDQAAVLEED 286
L + T + + + L + + +KTL +L M+K +A + E +
Sbjct: 1168 LQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELEERE 1227
Query: 287 ---TTDDDNLELE-------------VNSQWENGANLDDPLKGALKKL-IHAAKLNVSLK 329
TT+ + L+ E + + + L LKG ++L H +L SL
Sbjct: 1228 KVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLN 1287
Query: 330 SLEGERNH--------------IIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFES 375
+ + E N + I L+++D H + L + +L+ EN + S
Sbjct: 1288 NAQLELNRWQARFDELKEQHQTMDISLTKLD-------NHCELLSRLKGNLEEENHHLLS 1340
Query: 376 ENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRK 435
+ Q L Q+N+M L + + +E Y E+++ + + L R+
Sbjct: 1341 QIQLLS----------QQNQMLLEQNMENKEQYHEEQKQYIDK-----------LNALRR 1379
Query: 436 LAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETEL 495
+ LEE++ FY +K+ H W+ A+ + L +KE + + K T
Sbjct: 1380 HKEKLEEKIMDQYKFYDPPP---KKKNH--WIGAKALVK-LIKPKKEGSRERLKSTVDSP 1433
Query: 496 KFELLEKDPNALDVSNTAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPG 555
++L DP + S + +P +P+ LG +E R + G
Sbjct: 1434 PWQLESSDPASPAASQPLRSQAENPDTPA-LGSNCAEERDAHN----------------G 1476
Query: 556 GGGRGPSSPGNPLDHQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQS 615
G+GP + +RG P L D A +D S P E R +
Sbjct: 1477 SVGKGPG--------DLKPKRGSPHRGSL-DRTDASTDLAMRSWPSELGSRTCSTSATTT 1527
Query: 616 YPDSTLPPQR---EDRFYSNSERLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDL 672
P ++ P R + Y++ + L P+ F++ + + S PS +ESSRN + +
Sbjct: 1528 APSNSTPIARHPGRTKGYNSDDNLCEPS--LEFEVPN-HRQYVSRPSSLESSRNTSSNS- 1583
Query: 673 GNLNVPDSS 681
LN+ SS
Sbjct: 1584 SPLNLKGSS 1592
Score = 63.2 bits (152), Expect = 9e-10
Identities = 107/499 (21%), Positives = 196/499 (39%), Gaps = 93/499 (18%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAA----EEARSLE 129
+ ++L + + E +L + SL ++ +ES L + E+ A E R
Sbjct: 753 KSERLELSYQSVSAENLRLQQ--SLESSSHKTQTLESELGELEAERQALRRDLEALRLAN 810
Query: 130 ATCEKLNRSNSELEDEILCLEKDLK--EEKSKHSQQ-----DELMADISKSIQSLEDESK 182
A E + LE E+ LEKD K E+++K Q D ++ D + + ++E ES+
Sbjct: 811 AQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESR 870
Query: 183 SLKSQIAEAKIICKTFKMSEERRAIAIKD---------ALNENSQLQTSHKQLFQQEAEV 233
+L ++A + K E+ K L E+ L+ Q E +
Sbjct: 871 ALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDK 930
Query: 234 WKGEVSE--LNKQKITFED---SKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTT 288
E+ + LN++ + ED S + + E+ +KT L M +++ +LE
Sbjct: 931 LSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTT---LAMKEEKIVLLEAQME 987
Query: 289 DDDNLELEVNSQWE--------------NGANLDDPLKGALKKLI--HAAK--------- 323
+ +L ++ S+ + G +L + K K H K
Sbjct: 988 EKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKE 1047
Query: 324 -----LNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQA-------SLQSENI 371
L V +++E ERN+ +Q K+ L E +++L+TQ +LQ ++
Sbjct: 1048 ATMELLRVKDRAIELERNNAALQAE-----KQLLKEQLQHLETQNVTFSSQILTLQKQSA 1102
Query: 372 YFESENQKLQ---QKLKIMTEFYQENEMKLYRKLTVEENYRIEEE---EKLSRVEEKISR 425
+ + N LQ KL++ L + T+ +N+ +E E L R +E+++
Sbjct: 1103 FLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTA 1162
Query: 426 ATEGLETYRKLAKDLEEELERTVHFYQKQVISYEK--RGHDNWLAARTAERNLSDLRKEN 483
A E L ++ E +++Q YE R H +T RNL KE
Sbjct: 1163 AYEA----------LLQDHEHLGTLHERQSAEYEALIRQHS---CLKTLHRNLELEHKEL 1209
Query: 484 AHNKQKLTETELKFELLEK 502
+ + + + E EK
Sbjct: 1210 GERHGDMLKRKAELEEREK 1228
Score = 47.8 bits (112), Expect = 4e-05
Identities = 90/437 (20%), Positives = 172/437 (39%), Gaps = 89/437 (20%)
Query: 119 KAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDEL------------ 166
K +E ++L T + N S+LE E L +DL++ K K + ++L
Sbjct: 586 KDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENG 645
Query: 167 ---------------------------------------MADISKSIQSLEDESKSLKSQ 187
+ ++S ++ LE ++K L ++
Sbjct: 646 RLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAE 705
Query: 188 IAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQ----EAEVWKGEVSELNK 243
E + + +T + + + A EN QL+ ++L + +A K E EL+
Sbjct: 706 NLELRRLVETMRFTSTKLA----QMERENQQLEREKEELRKNVDLLKALGKKSERLELSY 761
Query: 244 QKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWEN 303
Q ++ E+ ++ +Q L + +TL L ++ + L D + L L N+Q E
Sbjct: 762 QSVSAENLRL--QQSLESSSHKTQTLESELGELEAERQALRRDL---EALRL-ANAQLE- 814
Query: 304 GANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQ 363
GA D + AL++ A+L K LE E + Q+ D ++ T + ++ +
Sbjct: 815 GAEKD---RKALEQ--EVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKES 869
Query: 364 ASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIE---------EEE 414
+L E KL++ K + ++ + T+ E+ +E E +
Sbjct: 870 RALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELD 929
Query: 415 KLSRVEEKISRATE--------GLET-YRKLAKDLEEELERTVHFYQKQVISYEKRGHDN 465
KLS+ EK+ E G +T Y+ L E L+ T+ +++++ E + +
Sbjct: 930 KLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEK 989
Query: 466 WLAARTAERNLSDLRKE 482
R E L L+KE
Sbjct: 990 ASLNRQLESELQMLKKE 1006
Score = 46.6 bits (109), Expect = 9e-05
Identities = 96/420 (22%), Positives = 171/420 (40%), Gaps = 67/420 (15%)
Query: 110 SSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKE------EKSKHSQQ 163
SSL + A E L T +L R ELED+ L E E K Q+
Sbjct: 242 SSLSSEDKQHLAVE----LADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQE 297
Query: 164 DELMADISKSIQSLEDESKSLKSQIAEAKII------CKTFKMSEERRAIAIKDALNENS 217
+ +A ++S ++ DE SL+ + + + CK K+ + A + L E++
Sbjct: 298 NIQLAADARSARAYRDELDSLREKANRVERLELELTRCKE-KLHDVDFYKARMEELREDN 356
Query: 218 QLQTSHKQLFQQE---AEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLP 274
+ K + +++ A +V EL K+ + + SK+H ++ D +
Sbjct: 357 IILIETKAMLEEQLTAARARGDKVHELEKENLQLK-SKLHDLELDRDTDK---------- 405
Query: 275 MMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGE 334
K +LEE+ LE+ A+L L+ K +A + S KS E
Sbjct: 406 --KRIEELLEENMV----LEIAQKQSMNESAHLGWELEQLSK---NADLSDASRKSFVFE 456
Query: 335 RNHIII-QLSEVDKTKEELTEHIKNLQTQQASLQSENIY---FESENQKLQQKL-KIMTE 389
N ++ +++K + L I+ L+ L+ + E EN +L +K+ K+ T+
Sbjct: 457 LNECASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQ 516
Query: 390 FYQENEMKLYRKLTVEENYRIEE-EEKLSRVEEKISRATEGLETYR-KLAKDLEEELERT 447
+E + N +E E+L R +E++ E L+ + + KDLE+E +
Sbjct: 517 LEREKQ----------SNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHL 566
Query: 448 VHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNAL 507
+ + S +R + +E + D+ KEN Q +TE K LE + L
Sbjct: 567 ----NRAMWSLRERSQVS------SEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQL 616
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 71.2 bits (173), Expect = 3e-12
Identities = 96/471 (20%), Positives = 195/471 (41%), Gaps = 66/471 (14%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARS-LEATCE 133
E K A L+ L ++ +L+ + + E L+ +K AE+A + L+ +
Sbjct: 441 ESKQSAELNKLRQDYARLVNELT---------EKTGKLQQEEVQKKNAEQAATQLKVQLQ 491
Query: 134 KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI 193
+ R E++ I + + ++ + D+ + E+E +SL S++ + +
Sbjct: 492 EAERRWEEVQSYI----------RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 194 ICKTFKMSEERRAIAIKDA----LNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFE 249
K E+R + + ++ +N+ LQ + + +Q E K ++ + + Q
Sbjct: 542 S----KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQN-EALKAQIQQFHSQIAAQT 596
Query: 250 DSKVHAEQ---VLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGAN 306
+ V AE+ V+ +K+ IK L +D+ EE+ D N+
Sbjct: 597 SASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL---------- 646
Query: 307 LDDPLKGALKKLIHAAKLNVSLK-SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQAS 365
LK ++KL A + LE + + ++ ++ +E+L I N +
Sbjct: 647 ----LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI 702
Query: 366 LQSENIYFESENQKLQ---------QKLKIMTEFYQENEMKLYRKLTVEENYRIE---EE 413
L +N +SE QKLQ ++ M + QE + KL + E I+ +E
Sbjct: 703 LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
Query: 414 EKLSRVEEKISRATEGLETYRKLAKD------LEEELERTVHFYQKQVISYEKRGHDNWL 467
E+L+ + + S T+ ++ + D L EEL++ +H ++ S E+ L
Sbjct: 763 EELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
Query: 468 AARTAERNLSDLRKENAHNKQKLTETEL-KFELLEKDPNALDVSNTAFGRE 517
E+ + DL++E K+++ +L K + L ++ N G+E
Sbjct: 823 KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/383 (20%), Positives = 168/383 (43%), Gaps = 38/383 (9%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEK--AAAEEARSLEAT 131
+++++ T L E+ +L K ++E + + + L A +K A A E +
Sbjct: 612 KDKQIKQTEDSLASERDRLTSK----EEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 667
Query: 132 CEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEA 191
EK+ +S +D+I LE+ L+ E S ++ +++ D +K+++S + ++L S+
Sbjct: 668 LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727
Query: 192 KIICKTFKMSEER-RAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQ------ 244
++ + K +E+ + + L E +Q + K ++E + E S L K+
Sbjct: 728 DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATK---EEELNAIRTENSSLTKEVQDLKA 784
Query: 245 ----KITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
+++F ++V+++K+ IK++ L + A E+ D L+ E+ +
Sbjct: 785 KQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQD---LKQEIKAL 841
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
E N+ L +L LK E + N + L E +K + +++LQ
Sbjct: 842 KEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ 901
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
+ SL++ + Q LK + Q E+++ K E+E +L R+E
Sbjct: 902 EENESLKAH------VQEVAQHNLKEASSASQFEELEIVLK---------EKENELKRLE 946
Query: 421 EKISRATEGLETYRKLAKDLEEE 443
+ L + +L +D+++E
Sbjct: 947 AMLKERESDLSSKTQLLQDVQDE 969
Score = 60.8 bits (146), Expect = 5e-09
Identities = 90/392 (22%), Positives = 174/392 (44%), Gaps = 50/392 (12%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEAT--C 132
+Q+L L L+E + K + K +Q + + ++ A ++ ++ A A+
Sbjct: 543 KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA 602
Query: 133 EKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAK 192
E+L++ +E + +I E L E+ + + ++E + DI L+ E + L++ E
Sbjct: 603 EELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQA 662
Query: 193 IICKTFKMSEERRAIAIKD----ALNENSQLQTSHK----QLFQQEAEVWKGEVSELNK- 243
++ + ++++ +KD L E Q + S+K ++ + + K EV +L
Sbjct: 663 --AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 244 -QKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDT----TDDDNLELEVN 298
+ +D E+ + +K+ +KT+ L Q A EE+ T++ +L EV
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 299 S--QWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHI 356
+N L LKK+IH + + +KS+E +++++ +KT ++L + I
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIH--EKDGKIKSVEELLEAELLKVANKEKTVQDLKQEI 838
Query: 357 KNLQTQQASLQSEN---IYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
K L+ + ++Q E + S+ Q+LQ LK E Q N MK +EE+
Sbjct: 839 KALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEE--QMNTMKAV----------LEEK 886
Query: 414 EKLSRVEEKISRATEGLETYRKLAKDLEEELE 445
EK L K +DL+EE E
Sbjct: 887 EK-------------DLANTGKWLQDLQEENE 905
Score = 51.2 bits (121), Expect = 4e-06
Identities = 108/455 (23%), Positives = 187/455 (41%), Gaps = 77/455 (16%)
Query: 70 LYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLE 129
L G+E+++ T+ ++EEK K L K + + E+ A ++ A +
Sbjct: 868 LLKGKEEQMN-TMKAVLEEKEKDLANTG---KWLQDLQEENESLKAHVQEVAQHNLKEAS 923
Query: 130 ATC--EKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQ 187
+ E+L E E+E+ LE LKE +S S + +L+ D+ +DE+K KSQ
Sbjct: 924 SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV-------QDENKLFKSQ 976
Query: 188 IAEAKIICKTFKMSEERRAIAIKDALNENSQLQTS---HKQLFQQEAEVWKGEVSELNKQ 244
I + K +N Q +S H++L + +E K E+S L +
Sbjct: 977 IEQLK---------------------QQNYQQASSFPPHEELLKVISEREK-EISGLWNE 1014
Query: 245 KITFEDSKVHAEQVLNDKENH----IKTLTGHLPMMKDQA-AVLEEDTTDDDNLELEVN- 298
+ +D+ H + ND ++ L M++D+ +E + +ELE
Sbjct: 1015 LDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKE 1074
Query: 299 -----------------SQWENGANLDDPLKGALKKLIHAAKLNV-SLKSLEGERNHIII 340
+W +G + K + + ++ V K E + H ++
Sbjct: 1075 VLKKLFPKVSVPSNLSYGEWLHG--FEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLL 1132
Query: 341 QLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYR 400
QL E +K K L E LQ Q S++ E ++ + + + +K M + +E +L R
Sbjct: 1133 QL-ECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELER 1191
Query: 401 KLTVEENYRIE----EEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTV-HFYQKQV 455
+ EN IE E E L EK T + KDL EL++ + Y + V
Sbjct: 1192 LRS--ENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAV 1249
Query: 456 ISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKL 490
E+ N L A+ E L+ LR E + +QK+
Sbjct: 1250 RQNEEL---NLLKAQLNE-TLTKLRTEQ-NERQKV 1279
Score = 32.0 bits (71), Expect = 2.3
Identities = 31/143 (21%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
Query: 99 IQKEYEGYEVESSL---EDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKE 155
++ E E E+E S E + E + L+ + + R N EL L + L +
Sbjct: 1209 LEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK 1268
Query: 156 EKSKHSQQDELMADISKSIQSLE-DESKSLKSQ-----IAEAKIICKTFKMSEERRAIAI 209
+++ +++ ++ D+ K+ QSLE +SK +K+ I + + +T +E ++++
Sbjct: 1269 LRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSL 1328
Query: 210 KDALNENSQLQTSHKQLFQQEAE 232
+ + QL + Q +E E
Sbjct: 1329 NQTVTQLQQLLQAVNQQLTKEKE 1351
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 71.2 bits (173), Expect = 3e-12
Identities = 96/471 (20%), Positives = 195/471 (41%), Gaps = 66/471 (14%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARS-LEATCE 133
E K A L+ L ++ +L+ + + E L+ +K AE+A + L+ +
Sbjct: 441 ESKQSAELNKLRQDYARLVNELT---------EKTGKLQQEEVQKKNAEQAATQLKVQLQ 491
Query: 134 KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKI 193
+ R E++ I + + ++ + D+ + E+E +SL S++ + +
Sbjct: 492 EAERRWEEVQSYI----------RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 194 ICKTFKMSEERRAIAIKDA----LNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFE 249
K E+R + + ++ +N+ LQ + + +Q E K ++ + + Q
Sbjct: 542 S----KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQN-EALKAQIQQFHSQIAAQT 596
Query: 250 DSKVHAEQ---VLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGAN 306
+ V AE+ V+ +K+ IK L +D+ EE+ D N+
Sbjct: 597 SASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL---------- 646
Query: 307 LDDPLKGALKKLIHAAKLNVSLK-SLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQAS 365
LK ++KL A + LE + + ++ ++ +E+L I N +
Sbjct: 647 ----LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI 702
Query: 366 LQSENIYFESENQKLQ---------QKLKIMTEFYQENEMKLYRKLTVEENYRIE---EE 413
L +N +SE QKLQ ++ M + QE + KL + E I+ +E
Sbjct: 703 LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
Query: 414 EKLSRVEEKISRATEGLETYRKLAKD------LEEELERTVHFYQKQVISYEKRGHDNWL 467
E+L+ + + S T+ ++ + D L EEL++ +H ++ S E+ L
Sbjct: 763 EELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
Query: 468 AARTAERNLSDLRKENAHNKQKLTETEL-KFELLEKDPNALDVSNTAFGRE 517
E+ + DL++E K+++ +L K + L ++ N G+E
Sbjct: 823 KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873
Score = 62.0 bits (149), Expect = 2e-09
Identities = 79/383 (20%), Positives = 168/383 (43%), Gaps = 38/383 (9%)
Query: 74 REQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEK--AAAEEARSLEAT 131
+++++ T L E+ +L K ++E + + + L A +K A A E +
Sbjct: 612 KDKQIKQTEDSLASERDRLTSK----EEELKDIQNMNFLLKAEVQKLQALANEQAAAAHE 667
Query: 132 CEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEA 191
EK+ +S +D+I LE+ L+ E S ++ +++ D +K+++S + ++L S+
Sbjct: 668 LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727
Query: 192 KIICKTFKMSEER-RAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQ------ 244
++ + K +E+ + + L E +Q + K ++E + E S L K+
Sbjct: 728 DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATK---EEELNAIRTENSSLTKEVQDLKA 784
Query: 245 ----KITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQ 300
+++F ++V+++K+ IK++ L + A E+ D L+ E+ +
Sbjct: 785 KQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQD---LKQEIKAL 841
Query: 301 WENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQ 360
E N+ L +L LK E + N + L E +K + +++LQ
Sbjct: 842 KEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQ 901
Query: 361 TQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVE 420
+ SL++ + Q LK + Q E+++ K E+E +L R+E
Sbjct: 902 EENESLKAH------VQEVAQHNLKEASSASQFEELEIVLK---------EKENELKRLE 946
Query: 421 EKISRATEGLETYRKLAKDLEEE 443
+ L + +L +D+++E
Sbjct: 947 AMLKERESDLSSKTQLLQDVQDE 969
Score = 60.8 bits (146), Expect = 5e-09
Identities = 90/392 (22%), Positives = 174/392 (44%), Gaps = 50/392 (12%)
Query: 75 EQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEAT--C 132
+Q+L L L+E + K + K +Q + + ++ A ++ ++ A A+
Sbjct: 543 KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA 602
Query: 133 EKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAK 192
E+L++ +E + +I E L E+ + + ++E + DI L+ E + L++ E
Sbjct: 603 EELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQA 662
Query: 193 IICKTFKMSEERRAIAIKD----ALNENSQLQTSHK----QLFQQEAEVWKGEVSELNK- 243
++ + ++++ +KD L E Q + S+K ++ + + K EV +L
Sbjct: 663 --AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 244 -QKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDT----TDDDNLELEVN 298
+ +D E+ + +K+ +KT+ L Q A EE+ T++ +L EV
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 299 S--QWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHI 356
+N L LKK+IH + + +KS+E +++++ +KT ++L + I
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIH--EKDGKIKSVEELLEAELLKVANKEKTVQDLKQEI 838
Query: 357 KNLQTQQASLQSEN---IYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
K L+ + ++Q E + S+ Q+LQ LK E Q N MK +EE+
Sbjct: 839 KALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEE--QMNTMKAV----------LEEK 886
Query: 414 EKLSRVEEKISRATEGLETYRKLAKDLEEELE 445
EK L K +DL+EE E
Sbjct: 887 EK-------------DLANTGKWLQDLQEENE 905
Score = 51.2 bits (121), Expect = 4e-06
Identities = 108/455 (23%), Positives = 187/455 (41%), Gaps = 77/455 (16%)
Query: 70 LYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLE 129
L G+E+++ T+ ++EEK K L K + + E+ A ++ A +
Sbjct: 868 LLKGKEEQMN-TMKAVLEEKEKDLANTG---KWLQDLQEENESLKAHVQEVAQHNLKEAS 923
Query: 130 ATC--EKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQ 187
+ E+L E E+E+ LE LKE +S S + +L+ D+ +DE+K KSQ
Sbjct: 924 SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV-------QDENKLFKSQ 976
Query: 188 IAEAKIICKTFKMSEERRAIAIKDALNENSQLQTS---HKQLFQQEAEVWKGEVSELNKQ 244
I + K +N Q +S H++L + +E K E+S L +
Sbjct: 977 IEQLK---------------------QQNYQQASSFPPHEELLKVISEREK-EISGLWNE 1014
Query: 245 KITFEDSKVHAEQVLNDKENH----IKTLTGHLPMMKDQA-AVLEEDTTDDDNLELEVN- 298
+ +D+ H + ND ++ L M++D+ +E + +ELE
Sbjct: 1015 LDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKE 1074
Query: 299 -----------------SQWENGANLDDPLKGALKKLIHAAKLNV-SLKSLEGERNHIII 340
+W +G + K + + ++ V K E + H ++
Sbjct: 1075 VLKKLFPKVSVPSNLSYGEWLHG--FEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLL 1132
Query: 341 QLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYR 400
QL E +K K L E LQ Q S++ E ++ + + + +K M + +E +L R
Sbjct: 1133 QL-ECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELER 1191
Query: 401 KLTVEENYRIE----EEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTV-HFYQKQV 455
+ EN IE E E L EK T + KDL EL++ + Y + V
Sbjct: 1192 LRS--ENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAV 1249
Query: 456 ISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKL 490
E+ N L A+ E L+ LR E + +QK+
Sbjct: 1250 RQNEEL---NLLKAQLNE-TLTKLRTEQ-NERQKV 1279
Score = 32.0 bits (71), Expect = 2.3
Identities = 31/143 (21%), Positives = 66/143 (46%), Gaps = 9/143 (6%)
Query: 99 IQKEYEGYEVESSL---EDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKE 155
++ E E E+E S E + E + L+ + + R N EL L + L +
Sbjct: 1209 LEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTK 1268
Query: 156 EKSKHSQQDELMADISKSIQSLE-DESKSLKSQ-----IAEAKIICKTFKMSEERRAIAI 209
+++ +++ ++ D+ K+ QSLE +SK +K+ I + + +T +E ++++
Sbjct: 1269 LRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSL 1328
Query: 210 KDALNENSQLQTSHKQLFQQEAE 232
+ + QL + Q +E E
Sbjct: 1329 NQTVTQLQQLLQAVNQQLTKEKE 1351
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 71.2 bits (173), Expect = 3e-12
Identities = 109/566 (19%), Positives = 224/566 (39%), Gaps = 84/566 (14%)
Query: 59 LWRSFRSVRSRLYVGREQ--KLGATLSGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDAS 116
+WR +R + REQ K+ L E++ +L E+ ++++ + E E +++
Sbjct: 257 MWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQ- 315
Query: 117 FEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQS 176
E+ E+ + EK+ R L ++ EK ++E++ K Q+E M + + ++
Sbjct: 316 -EEKMWEQEEKMREQEEKMWRQEERLWEQ----EKQMREQEQKMRDQEERMWEQDERLRE 370
Query: 177 LEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQ-QEAEVWK 235
E+ + + + + KM EE R + + E + ++ Q QE +W+
Sbjct: 371 KEERMREQEKMWEQEE------KMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 236 GEVSELNKQKITFEDSKVHAEQVLNDKENHI----------KTLTGHLPMM--------- 276
E E +Q++ + K+ ++ + ++E I + + G M
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Query: 277 KDQAAVLEEDTTDDDNLELEVNSQ-WENGANL---DDPLKGALKKLIHAAKLNVSLKSLE 332
+DQ EE D + + + WE L ++ ++ K K+ K+ E
Sbjct: 485 EDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE 544
Query: 333 GERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKL---QQKLKIMTE 389
E+ E + +E + E K ++ ++ ++ + + + +K+ ++K+ E
Sbjct: 545 QEKK--TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEE 602
Query: 390 FYQENEMKLYR------------KLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLA 437
QE E K++ K+ +E E+EEK+ EEK+ E + +
Sbjct: 603 KMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKM 662
Query: 438 KDLEEEL---ERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETE 494
++ EE++ E + ++++ E++ + R E + ++ ++K+ E
Sbjct: 663 REQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQE 722
Query: 495 LKFELLEKDPNALDVSNTAFGR--EH-----SPCSPSPLGRPSSETRAFPSPQTLLEDPL 547
E+ EK+ D R EH PC P P +L +
Sbjct: 723 ---EMREKEERIRDQKEKMQERLPEHEERCSEPCLP---------------PSKVLCNMS 764
Query: 548 RLSPVLPGGGGRGPSSP-GNPLDHQI 572
V P GG G SP NP +I
Sbjct: 765 HTGSVEPAGGEAGEGSPQDNPTAQEI 790
Score = 59.7 bits (143), Expect = 1e-08
Identities = 84/441 (19%), Positives = 187/441 (42%), Gaps = 47/441 (10%)
Query: 86 IEEKCKLLE-KFSLIQKEYEGYEVESSLEDASF------EKAAAEEARSLEATCEKLNRS 138
++EK +L E + S IQ + E++ LE A F EE E + +
Sbjct: 192 LQEKLRLAESEKSEIQLNVK--ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKK 249
Query: 139 NSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
+ E+++ E+ L+E++ K +Q+E M K ++ E E + + ++ E K
Sbjct: 250 IRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQ----KKL 305
Query: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGE--VSELNKQKITFEDSKVHAE 256
+ EE+ + + +++ +++++QE +W+ E + E ++ E+ +
Sbjct: 306 REQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQD 365
Query: 257 QVLNDKENHIK----------TLTGHLPMMKDQAAVLEEDTT---DDDNLELEVNSQWEN 303
+ L +KE ++ + + + + + EE+ T ++ ++ + + WE
Sbjct: 366 ERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 425
Query: 304 GAN--LDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQT 361
L +KL K+ E+ I + E + +EE+ K +
Sbjct: 426 EEKEWQQQRLPEQKEKLWEQEKMQ--------EQEEKIWEQEEKIRDQEEMWGQEKKMWR 477
Query: 362 QQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEE 421
Q+ + E+ +E E + Q+ K+ + QE M + E+ R+ E++K+ + EE
Sbjct: 478 QEKMREQEDQMWEQEEKMRDQEQKM---WDQEERMWEQDERLREKEERMREQKKMWQQEE 534
Query: 422 KISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRK 481
K+ R + + K D EE++ ++++ EK+ + R E + + +
Sbjct: 535 KM-REEKKTQEQEKKTWDQEEKMRE-----EERMREREKKMREEEEMMREQEEKMQEQEE 588
Query: 482 ENAHNKQKLTETELKFELLEK 502
+ ++K+ E E K + E+
Sbjct: 589 KMREQEEKMWEQEEKMQEQEE 609
Score = 45.4 bits (106), Expect = 2e-04
Identities = 63/285 (22%), Positives = 110/285 (38%), Gaps = 43/285 (15%)
Query: 223 HKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAV 282
H++ ++E E + L QK E + +++ E+ G+L KD A
Sbjct: 79 HQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFED------GNLGESKDLAGR 132
Query: 283 LEEDTTDDDNLE--LEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIII 340
L L+ L S W K + ++ L ER+ + +
Sbjct: 133 LHHSWHFAGELQRALSAVSTWHK-------------------KADRYIEELTKERDALSL 173
Query: 341 QLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKL---KIMTEFYQENEMK 397
+L T EEL + LQ + +SE + ++L++KL K + Q N
Sbjct: 174 ELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTN--T 231
Query: 398 LYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVIS 457
L ++ +E E+E+K+ + EEK+ R E L ++ EE++ R
Sbjct: 232 LQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRR----------- 280
Query: 458 YEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEK 502
EKR + R E+ L + +K +Q + E +E EK
Sbjct: 281 QEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEK 325
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 71.2 bits (173), Expect = 3e-12
Identities = 98/425 (23%), Positives = 187/425 (44%), Gaps = 68/425 (16%)
Query: 100 QKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSK 159
+ E ++ LE + + A E R L+ ++L + S+ E+++ L L E+++
Sbjct: 1362 EAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAA 1421
Query: 160 HSQ-QDELMA--DISKSIQS-LEDESKSLKSQIAEAKI-IC----KTFKMSEERRA---- 206
++ Q E++ D+ K++ + LE ++K +I + ++ +C K ++ EE RA
Sbjct: 1422 LTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQI 1481
Query: 207 --------IAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQV 258
I+ K+AL EN L Q+E + +G + L K E S+V A+
Sbjct: 1482 QRKLQAALISRKEALKENKSL--------QEELSLARGTIERLTKSLADVE-SQVSAQNK 1532
Query: 259 LNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKL 318
D T+ G L +++++ L T+ D LE S + +L L+G +
Sbjct: 1533 EKD------TVLGRLALLQEERDKL---ITEMDRSLLENQSLSSSCESLKLALEGLTEDK 1583
Query: 319 IHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQS-ENIYFESEN 377
K SLKS S++ ++ E +H + + + LQS EN+ E+E
Sbjct: 1584 EKLVKEIESLKS------------SKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE- 1630
Query: 378 QKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLA 437
+++ + E ++ + +LY KL E + E E++L E+++ E + + K
Sbjct: 1631 -----RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSK 1685
Query: 438 KDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKF 497
+ ELE + +V A TA+ + L NA K++L ++++
Sbjct: 1686 QQKILELEEENDRLRAEVHP----------AGDTAKECMETLLSSNASMKEELERVKMEY 1735
Query: 498 ELLEK 502
E L K
Sbjct: 1736 ETLSK 1740
Score = 62.4 bits (150), Expect = 2e-09
Identities = 83/390 (21%), Positives = 163/390 (41%), Gaps = 52/390 (13%)
Query: 85 LIEEKCKLLEKFSLIQKEYEGYEVESSL-----EDASFEKAAAEEARSLEATCEKLNRSN 139
L E+ C +L K L Q E++ ++ + +E A E + + C+ L N
Sbjct: 2228 LKEDNCSVL-KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286
Query: 140 SEL--------------EDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLK 185
EL ++E+ LE +LK K + + D+S S++ +++ +L+
Sbjct: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQ-------LTDLSNSLEKCKEQKGNLE 2339
Query: 186 SQIAEAKIICKTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQK 245
I + + + K S E+ ++ + S+L H+++ +E ++ +S L+ ++
Sbjct: 2340 GIIRQQEADIQNSKFSYEQLETDLQASRELTSRL---HEEINMKEQKI----ISLLSGKE 2392
Query: 246 ITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDT---TDDDNLELEV----- 297
E +V ++ + IK L L +++ VLEE+ D N +E
Sbjct: 2393 ---EAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK 2449
Query: 298 NSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQ----LSEVDKTKEELT 353
+ A LD +K ++ + LE II++ + E +L
Sbjct: 2450 KENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLK 2509
Query: 354 EHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEE 413
E I+ L++ L SEN ++E + ++ L + + +L L V+ E E
Sbjct: 2510 EEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL---LEVQLQQNKELE 2566
Query: 414 EKLSRVEEKISRATEGLETYRKLAKDLEEE 443
K +++EEK+ + E E R+ L+EE
Sbjct: 2567 NKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
Score = 55.8 bits (133), Expect = 1e-07
Identities = 92/450 (20%), Positives = 177/450 (39%), Gaps = 81/450 (18%)
Query: 83 SGLIEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSEL 142
S I E + EK +QKEYE + S E+ S EA ++ E + + EL
Sbjct: 1595 SSKIAESTEWQEKHKELQKEYE--ILLQSYENVS------NEAERIQHVVEAVRQEKQEL 1646
Query: 143 EDEILCLE-------KDLKEEKSKHSQQDELMADISKSIQS----LEDESKSLKSQIAEA 191
++ E K L+E + + + E M +KS Q LE+E+ L++++ A
Sbjct: 1647 YGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA 1706
Query: 192 ---------KIICKTFKMSEERRAIAIK-DALNENSQLQTSHKQLFQQEAEVWKGEVSEL 241
++ M EE + ++ + L++ Q S K +E + K ++
Sbjct: 1707 GDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGN 1766
Query: 242 NKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQW 301
++ E ++ H Q N E +++ G +T + D+L +
Sbjct: 1767 VSKQANLEATEKHDNQT-NVTEEGTQSIPG--------------ETEEQDSLSMSTRPTC 1811
Query: 302 ENGANLDDPLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQT 361
A+ K S E N+ + Q+ ++L E I L+
Sbjct: 1812 SESVPSAKSANPAVSKDF----------SSHDEINNYLQQI-------DQLKERIAGLEE 1854
Query: 362 QQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEE 421
++ + + E+E L ++ ++ E+K+ ++ + N ++ ++E
Sbjct: 1855 EKQKNKEFSQTLENEKNTLLSQIST-----KDGELKMLQEEVTKMNLLNQQ------IQE 1903
Query: 422 KISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRK 481
++SR T+ ET + DLEE L + + +Y + D + E + +L+K
Sbjct: 1904 ELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKK 1963
Query: 482 ---ENAHNKQKL------TETELKFELLEK 502
E KQ+L E+E++ E LEK
Sbjct: 1964 CVSELEEEKQQLVKEKTKVESEIRKEYLEK 1993
Score = 54.3 bits (129), Expect = 4e-07
Identities = 83/384 (21%), Positives = 161/384 (41%), Gaps = 63/384 (16%)
Query: 82 LSGLIEEKCKLLEKFSLI------QKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKL 135
LS +E+ ++ FS ++++ E+E + ++ +A + + A + L
Sbjct: 2820 LSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSL 2879
Query: 136 NRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIIC 195
++ S L+++ L K+LK + ++ Q I++ I L LK+Q+ E +
Sbjct: 2880 KKAMSSLQNDRDRLLKELKNLQQQYLQ-------INQEITELHP----LKAQLQEYQDKT 2928
Query: 196 KTFKMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHA 255
K F++ +E + EN Q QL + E W+ + +Q + K
Sbjct: 2929 KAFQIMQE-------ELRQENLSWQHELHQL-RMEKSSWEIHERRMKEQYLMAISDK--- 2977
Query: 256 EQVLNDKENHIKTL------TGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDD 309
+Q L+ +N I+ L T L + + A E + D + L ++ L+D
Sbjct: 2978 DQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLR-TQLND 3036
Query: 310 PLKGALKKLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSE 369
LK +K + +LN + L E+N + IQL + ++ E +H +L A L+ +
Sbjct: 3037 SLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQ 3096
Query: 370 ----------------------NIYFESENQKLQQKLKIMTEFYQE-----NEMKLYRKL 402
++ +S+ ++L++ + +E Q+ E+ RKL
Sbjct: 3097 VQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKL 3156
Query: 403 TVEE-NYRIEEEEKLSRVEEKISR 425
EE + R+ E LS EE+I R
Sbjct: 3157 LEEERDQRVAAENALSVAEEQIRR 3180
Score = 46.2 bits (108), Expect = 1e-04
Identities = 70/351 (19%), Positives = 153/351 (43%), Gaps = 39/351 (11%)
Query: 107 EVESSLEDASFEKAAAEEARSLEATCEKLNRSN-SELEDEILCLEKDLKEEKSKHSQQDE 165
E++ + E+ +F K + R+ EA E L++ ++E E + K +K Q
Sbjct: 565 EMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIK-MKVFLEDTGQDFP 623
Query: 166 LMADISKSIQSLEDESKSLKSQ--------IAEAKIICKTFKMSEERRAIAIKDALN-EN 216
LM + S+ ++E E S + Q + +A + K+ K ++ A+ D
Sbjct: 624 LMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683
Query: 217 SQLQTSHKQLFQQEAEVWKG-------------EVSELNKQKITFE---DSKVHAEQVLN 260
+L+ Q+ + E K E+S LN+ F+ D+ A L+
Sbjct: 684 DELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALS 743
Query: 261 DKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKL-I 319
++ + + + L M+ + A +++ + E + +E+ D+ L + L I
Sbjct: 744 EERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803
Query: 320 HAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQK 379
A +V ++ L+ E + + +Q SE I++LQ+Q + +SE + +
Sbjct: 804 EAKSKDVKIEVLQNELDDVQLQFSEQSTL-------IRSLQSQLQNKESEVLEGAERVRH 856
Query: 380 LQQKLKIMTEFYQENEMKLYR--KLTVEENYRIEEEEKLSRVEEKISRATE 428
+ K++ +++ + E+++ + +L +E+ +E ++ +EEK + TE
Sbjct: 857 ISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQT--IEEKDQQVTE 905
Score = 45.8 bits (107), Expect = 2e-04
Identities = 92/439 (20%), Positives = 194/439 (44%), Gaps = 70/439 (15%)
Query: 86 IEEKCKLLEKFSLIQKEYEGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDE 145
++EK K + + + +E++ +++ ++S A +EE L + ++L+ +EL +
Sbjct: 711 LDEKAKEISNLNQLIEEFK----KNADNNSSAFTALSEERDQLLSQVKELSMV-TELRAQ 765
Query: 146 ILCLEKDLKEEKSKH-------SQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTF 198
+ LE +L E + + + D L+ + S+ S+E +SK +K ++ + ++
Sbjct: 766 VKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSL-SIEAKSKDVKIEVLQNELDDVQL 824
Query: 199 KMSEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHA-EQ 257
+ SE+ ++ +++ QL +E+EV +G +++ SKV Q
Sbjct: 825 QFSEQ------------STLIRSLQSQLQNKESEVLEGA------ERVRHISSKVEELSQ 866
Query: 258 VLNDKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVN-SQWENGANLDDPLKGALK 316
L+ KE I + L K L++ + D E++ S E L++
Sbjct: 867 ALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNE------- 919
Query: 317 KLIHAAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESE 376
L V +K+L+ + N LS ++ K+E E + + S + Y E
Sbjct: 920 ---EKFSLGVEIKTLKEQLN----LLSRAEEAKKEQVE-----EDNEVSSGLKQNYDEMS 967
Query: 377 NQKLQQKLKIMTEF---YQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETY 433
K ++ EF +ENE + RKL R E +++SR+EE+++ + +
Sbjct: 968 PAGQISKEELQHEFDLLKKENEQRK-RKLQAALINRKELLQRVSRLEEELANLKDESKKE 1026
Query: 434 RKLAK----DLEEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQK 489
L++ ++EE+ E Y ++ ++ + + + +L ++ +S+ E H ++
Sbjct: 1027 IPLSETERGEVEEDKENKE--YSEKCVTSKCQEIEIYL-----KQTISEKEVELQHIRKD 1079
Query: 490 LTE---TELKFELLEKDPN 505
L E E +F+ L K N
Sbjct: 1080 LEEKLAAEEQFQALVKQMN 1098
Score = 45.1 bits (105), Expect = 3e-04
Identities = 87/418 (20%), Positives = 166/418 (39%), Gaps = 72/418 (17%)
Query: 62 SFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSL----IQKEYEGYEVESSLEDASF 117
S ++ R R+ VG Q+L +I EK +L+++ + +++E G + S ++D +
Sbjct: 2468 SLQNDRDRI-VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRG--LRSHMDDLNS 2524
Query: 118 EKAAAEEARSLEATCEKLNR------------------SNSELEDEILCLEKDLKEEKSK 159
E A + L E LN+ N ELE++ LE+ LKE +
Sbjct: 2525 ENAKLDA--ELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEA 2582
Query: 160 HSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQL 219
+ + + Q L E +SLK I S+ R + AL E L
Sbjct: 2583 NEDLRRSFNALQEEKQDLSKEIESLKVSI------------SQLTRQVT---ALQEEGTL 2627
Query: 220 QTSHKQLFQQEAEVWK---------GEVSELNKQKITFEDSKVHAEQVLNDK-ENHIKTL 269
H QL +E EV + ++EL ++ + + + DK + +K L
Sbjct: 2628 GLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHL 2687
Query: 270 TGHLPMMKDQAAVLEEDTTD--DDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVS 327
+M+++ EE + D +E+E N KG ++ S
Sbjct: 2688 HHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKEN-----KGLTAQI---QSFGRS 2739
Query: 328 LKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQ------QASLQSENIYF--ESENQK 379
+ SL+ R+H +L E+ + + + + L+ Q + +L SE + +E
Sbjct: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENS 2799
Query: 380 LQQKLKIMTEFYQENEMKLYRKLTVEENYRIEE--EEKLSRVEEKISRATEGLETYRK 435
L K+ + ++E L+ +E++Y + + ++ ++ + LE +RK
Sbjct: 2800 LSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRK 2857
Score = 37.7 bits (86), Expect = 0.041
Identities = 71/356 (19%), Positives = 145/356 (40%), Gaps = 50/356 (14%)
Query: 141 ELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLEDESKSLKSQIAEAKIICKTFKM 200
ELE++IL LEK+ KE+ K Q E + ++ +++ + L+ ++ + K +
Sbjct: 1161 ELEEKILALEKE-KEQLQKKLQ--EALTSRKAILKKAQEKERHLREELKQQK---DDYNR 1214
Query: 201 SEERRAIAIKDALNENSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLN 260
+E+ + EN + +QL Q E G++ ++Q+ +
Sbjct: 1215 LQEQ----FDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKA 1270
Query: 261 DKENHIKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIH 320
+++H + VLE + D W + + L+G
Sbjct: 1271 TEQHHTQ-------------PVLESNLCPD----------WPSHSEDASALQGGTS---- 1303
Query: 321 AAKLNVSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKL 380
A++ LK +E E+ + +++S T ELT+ + + Q + + + ES + +
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVS---STTSELTKKSEEVFQLQEQINKQGLEIES-LKTV 1359
Query: 381 QQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDL 440
+ ++ E Q+ ++ E+ R E + KL +++ IS+ E + L+ L
Sbjct: 1360 SHEAEVHAESLQQKLESSQLQIAGLEHLR-ELQPKLDELQKLISKKEEDVS---YLSGQL 1415
Query: 441 EEELERTVHFYQKQVISYE---KRGHDNW-LAARTAERNLSDLRKENAHNKQKLTE 492
E+ E + Q ++I E K H + A+ + + L+ E KQK E
Sbjct: 1416 SEK-EAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE 1470
Score = 36.6 bits (83), Expect = 0.091
Identities = 81/416 (19%), Positives = 155/416 (37%), Gaps = 82/416 (19%)
Query: 110 SSLEDASFEKAAAEEARSLEATCE-KLNRSNSELEDEILCLEKDLKEEKSKHSQQDELM- 167
+ +E+ K +E +T + +L+++ +E + + EKD + E +DEL+
Sbjct: 180 TEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQ 239
Query: 168 ----ADISKSIQS--------LEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNE 215
AD+ +Q LE+ +SL + ++ + +E+R
Sbjct: 240 LVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRN---------- 289
Query: 216 NSQLQTSHKQLFQQEAEVWKGEVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPM 275
Q +QL Q EAE TL +
Sbjct: 290 ----QILSQQLQQMEAE---------------------------------HNTLRNTVET 312
Query: 276 MKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLNVSLKSLEGER 335
++++ +L E +ELEV + + NL + + L++ A + L+S R
Sbjct: 313 EREESKILLE------KMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES----R 362
Query: 336 NHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENE 395
+ Q + + EE T HI +LQ LQS + +N KL Q +
Sbjct: 363 YSALEQKHKAE--MEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI 420
Query: 396 MKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQV 455
+L +L + + +L + + + T + Y + + + EE + QK+V
Sbjct: 421 QQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEE---NIASLQKRV 477
Query: 456 ISYE-KRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVS 510
+ E ++G A + L +L+ EN ++T E + E D ++S
Sbjct: 478 VELENEKG-----ALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEIS 528
Score = 35.4 bits (80), Expect = 0.20
Identities = 85/428 (19%), Positives = 178/428 (41%), Gaps = 61/428 (14%)
Query: 104 EGYEVESSLEDASFEKAAAEEARSLEATCEKLNRSNSELEDEILCLEKDLK---EEKSKH 160
E E+E + SF EE L E+ ++ +ELE LE+ K EEK+ H
Sbjct: 322 EKMELEVAERKLSFHNLQ-EEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380
Query: 161 -SQQDELMADISKSIQSLEDE-SKSLKSQIAEAKIICKTFKMSE---ERRAIAIKDALN- 214
+ ++ + +L+D+ SK L+ + +A +T + E ++++ I LN
Sbjct: 381 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNR 440
Query: 215 -----ENSQLQTSHKQLFQQEAE-VWKGEVSELNKQKITFEDSK---VHAEQVLNDKENH 265
+ QTS ++ + + V + ++ L K+ + E+ K + + L + +
Sbjct: 441 LPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE 500
Query: 266 IKTLTGHLPMMKDQAAVLEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHAAKLN 325
+ L+ + +++ Q E D + +++ ++ + A + +
Sbjct: 501 NEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA--------------EESGQD 546
Query: 326 VSLKSLEGERNHIIIQLSEVDKTKEELTEHIKNLQTQQASLQSENIYFESENQKLQQK-- 383
V + + + + L E+ + +EE+ LQ ++A + + E ++++ +
Sbjct: 547 VLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGI 606
Query: 384 LKIMTEFYQENEMKLYRKLTVEENY--RIEEE----EKLSRVEEKISRATEGLE---TYR 434
I + + E+ + + + EE+ +E+E E SR E+IS G+E T +
Sbjct: 607 APIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQ 666
Query: 435 KLAKDL----------EEELERTVHFYQKQVISYEKRGHDNWLAARTAERNLSDLRKENA 484
K L ++ELER + Q++ E H A E+NL + KE +
Sbjct: 667 DGDKSLSAVPDIGQCHQDELER----LKSQILELELNFHK---AQEIYEKNLDEKAKEIS 719
Query: 485 HNKQKLTE 492
+ Q + E
Sbjct: 720 NLNQLIEE 727
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 70.9 bits (172), Expect = 4e-12
Identities = 110/565 (19%), Positives = 231/565 (40%), Gaps = 52/565 (9%)
Query: 64 RSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEY-----EGYEVESSLEDASFE 118
+ VR+ ++++ + LS EE + + +Q+E E + ++ LE+ +
Sbjct: 1449 QQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMD 1508
Query: 119 KAA-AEEARSLEATCEKLNRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSL 177
A ++ SLEA + ++ S+ E + ++K L++ ++K Q+E + + + +IQ L
Sbjct: 1509 IAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQML 1568
Query: 178 EDESKSLKSQI-----AEAKIICKTFKMSEERRAIAIKDALNENSQLQTSH--KQLFQQE 230
E L+ ++ +K + + EE R K QL+ + KQ +E
Sbjct: 1569 EQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLRE 1628
Query: 231 AEVWKGEVSELNKQ--KITFEDSK------VHAEQVLNDKENHIKTLTGHLPMMKDQAAV 282
+G+++ L+ Q + FE K + +L D + + L P ++ A +
Sbjct: 1629 KRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQL 1688
Query: 283 LEEDTTDDDNLELEVNSQWENGANLDDPLKGALKKLIHA-AKLNVSLKSLEGERNHIIIQ 341
+ + V ++ ++D L + + A L L L+ E+N I +
Sbjct: 1689 KNQLEESEFTCAAAVKARKAMEVEIED-LHLQIDDIAKAKTALEEQLSRLQREKNEIQNR 1747
Query: 342 LSEVDKTKEELTEHIKNLQTQQA-------SLQSENIYFESENQKLQQKLKIMTEFYQEN 394
L E + EL + K Q + LQ++ E Q+LQ+KL+ + ++
Sbjct: 1748 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQAL-----QS 1802
Query: 395 EMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQ 454
+++ + V+++ +E K+ +E ++ ++ LA L+E +E+ ++
Sbjct: 1803 QVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQR 1862
Query: 455 VISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAF 514
+ + + N + +R L D ++E +K E K LE D +L+ +N +
Sbjct: 1863 IAAENREKEQN----KRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSL 1918
Query: 515 GREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLRLSPVLPGGGGRGPSSPGNPLDHQITN 574
+ + Q +ED + G S + L+ ++
Sbjct: 1919 QAD-----------LKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDVDSELEDRVDG 1967
Query: 575 ERGEPSYDRLIDPHRAPSDTGSLSS 599
+ S ++ P +A SD GSL S
Sbjct: 1968 VKSWLSKNK--GPSKAASDDGSLKS 1990
Score = 39.3 bits (90), Expect = 0.014
Identities = 46/229 (20%), Positives = 98/229 (42%), Gaps = 11/229 (4%)
Query: 295 LEVNSQWENGANLDDPLKGALKKLIHAAK----LNVSLKSLEGERNHIIIQLSEVDKTKE 350
+EV E N D+ ++ KL A K L ++ LE + + +L++ T E
Sbjct: 1247 IEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGE 1306
Query: 351 ELTEHIKNLQTQQASLQSENIYFESENQKLQQKLKIMTEFYQENEMKLYRKLTVEENYRI 410
++ + ++ + E +++ L++++++M + E +L R E N +
Sbjct: 1307 SASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVME--MEVMEARLIR--AAEINGEV 1362
Query: 411 EEEEKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHFYQKQVISYEKRGHDNWLAAR 470
++++ K RA ++ +K L++E E + Q+ E+R D +
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKR---LQQEFEDKLEVEQQNKRQLERRLGDLQADSE 1419
Query: 471 TAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDVSNTAFGREHS 519
++R L L+K+ +L +T+L E + + L+ F E S
Sbjct: 1420 ESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELS 1468
Score = 32.7 bits (73), Expect = 1.3
Identities = 32/133 (24%), Positives = 61/133 (45%), Gaps = 20/133 (15%)
Query: 378 QKLQQKLKIMTEFYQENEMKLYRKLTVEENYRIEEEEKLSRVEEKISRATEGLETYRKLA 437
++LQQ+ + E Q+N+ +L R+L + E + L ++++K R T L+
Sbjct: 1387 KRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQ------ 1440
Query: 438 KDLEEELERTVHFYQKQVISYE----KRGHDNWLAARTAERNLSDLRKENAHNKQKLTET 493
+ +H +QV ++E +R D+ L+ E L++E ++ +
Sbjct: 1441 -------DTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLA 1493
Query: 494 E---LKFELLEKD 503
E LK +L EKD
Sbjct: 1494 EAFSLKQQLEEKD 1506
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.131 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,563,965
Number of Sequences: 37866
Number of extensions: 2213669
Number of successful extensions: 18844
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 272
Number of HSP's successfully gapped in prelim test: 1423
Number of HSP's that attempted gapping in prelim test: 10631
Number of HSP's gapped (non-prelim): 5854
length of query: 777
length of database: 18,247,518
effective HSP length: 110
effective length of query: 667
effective length of database: 14,082,258
effective search space: 9392866086
effective search space used: 9392866086
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.