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Search of human proteins with 193083145
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
(731 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 1486 0.0
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 1465 0.0
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 1452 0.0
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 125 1e-28
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 125 1e-28
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 125 1e-28
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 115 1e-25
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 115 1e-25
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 113 7e-25
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 113 7e-25
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 107 4e-23
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 106 9e-23
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 106 9e-23
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 106 9e-23
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 105 1e-22
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 105 1e-22
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 105 2e-22
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 103 4e-22
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 101 2e-21
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 101 2e-21
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 101 2e-21
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 101 2e-21
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 100 8e-21
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 100 8e-21
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 99 1e-20
gi|39930351 dynamin binding protein [Homo sapiens] 96 9e-20
gi|11321634 CD2-associated protein [Homo sapiens] 91 5e-18
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 88 2e-17
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 85 3e-16
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 84 5e-16
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 1486 bits (3846), Expect = 0.0
Identities = 731/731 (100%), Positives = 731/731 (100%)
Query: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA
Sbjct: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
Query: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP
Sbjct: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
Query: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK
Sbjct: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
Query: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLGLHEDPQSP 240
SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLGLHEDPQSP
Sbjct: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLGLHEDPQSP 240
Query: 241 PPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQ 300
PPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQ
Sbjct: 241 PPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQ 300
Query: 301 QPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQD 360
QPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQD
Sbjct: 301 QPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQD 360
Query: 361 PVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL 420
PVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL
Sbjct: 361 PVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL 420
Query: 421 RSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN 480
RSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN
Sbjct: 421 RSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN 480
Query: 481 QIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIII 540
QIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIII
Sbjct: 481 QIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIII 540
Query: 541 LKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVN 600
LKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVN
Sbjct: 541 LKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVN 600
Query: 601 SLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCP 660
SLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCP
Sbjct: 601 SLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCP 660
Query: 661 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 720
AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF
Sbjct: 661 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 720
Query: 721 PKNYIQFLQIS 731
PKNYIQFLQIS
Sbjct: 721 PKNYIQFLQIS 731
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 1465 bits (3792), Expect = 0.0
Identities = 730/767 (95%), Positives = 730/767 (95%), Gaps = 36/767 (4%)
Query: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA
Sbjct: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
Query: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP
Sbjct: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
Query: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK
Sbjct: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
Query: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLG-------- 232
SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVL
Sbjct: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
Query: 233 ----------------------------LHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 264
LHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE
Sbjct: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
Query: 265 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 324
RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK
Sbjct: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
Query: 325 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV 384
KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV
Sbjct: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV 420
Query: 385 MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVL 444
MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVL
Sbjct: 421 MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVL 480
Query: 445 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKR 504
HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKR
Sbjct: 481 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKR 540
Query: 505 ECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLN 564
ECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLN
Sbjct: 541 ECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLN 600
Query: 565 FVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFK 624
FVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFK
Sbjct: 601 FVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFK 660
Query: 625 RGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRG 684
RGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRG
Sbjct: 661 RGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRG 720
Query: 685 ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 731
ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS
Sbjct: 721 ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 767
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 1452 bits (3758), Expect = 0.0
Identities = 730/790 (92%), Positives = 730/790 (92%), Gaps = 59/790 (7%)
Query: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA
Sbjct: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
Query: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP
Sbjct: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
Query: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK
Sbjct: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
Query: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLG-------- 232
SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVL
Sbjct: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
Query: 233 ----------------------------LHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 264
LHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE
Sbjct: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
Query: 265 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 324
RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK
Sbjct: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
Query: 325 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYM------ 378
KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYM
Sbjct: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHG 420
Query: 379 -----------------RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 421
RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR
Sbjct: 421 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 480
Query: 422 SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ 481
SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ
Sbjct: 481 SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ 540
Query: 482 IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL 541
IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL
Sbjct: 541 IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL 600
Query: 542 KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS 601
KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS
Sbjct: 601 KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS 660
Query: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
Query: 662 EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP 721
EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP
Sbjct: 721 EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP 780
Query: 722 KNYIQFLQIS 731
KNYIQFLQIS
Sbjct: 781 KNYIQFLQIS 790
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 125 bits (314), Expect = 1e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 427 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 486
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 863 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 920
Query: 487 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 534
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 921 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 976
Query: 535 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 594
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 977 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1018
Query: 595 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 649
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 1019 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1078
Query: 650 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 708
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 1079 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1137
Query: 709 MSGELMGKSGIFPKNYIQ 726
GE+ G +G+FP NY++
Sbjct: 1138 WQGEINGVTGLFPSNYVK 1155
Score = 92.8 bits (229), Expect = 1e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 297 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 352
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 789 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 848
Query: 353 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 391
F V P P H + + + D++ +L+Q EN
Sbjct: 849 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 906
Query: 392 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 446
+ G G S +KII P E R P A + A ++V L+
Sbjct: 907 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 964
Query: 447 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 506
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 965 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1022
Query: 507 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 561
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 1023 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1080
Query: 562 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 618
P + V+ P + T + + + A++ + A
Sbjct: 1081 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1116
Query: 619 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 657
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 1117 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
Score = 78.6 bits (192), Expect = 2e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 423 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 477
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 1008 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1067
Query: 478 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 532
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 1068 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1120
Query: 533 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 587
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 1121 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1180
Query: 588 TKKE 591
K++
Sbjct: 1181 RKRQ 1184
Score = 73.6 bits (179), Expect = 6e-13
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 444 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 501
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 738 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 794
Query: 502 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 557
K ++ + V S E + + + VN W + R
Sbjct: 795 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 854
Query: 558 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 617
T + P V P+ G V +L A +AL S+TA+
Sbjct: 855 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 886
Query: 618 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 671
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 887 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 945
Query: 672 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 722
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 946 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1004
Query: 723 NYIQ 726
NY++
Sbjct: 1005 NYVK 1008
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 576
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796
Query: 577 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 636
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 797 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 843
Query: 637 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 696
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 844 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 896
Query: 697 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 897 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 927
Score = 53.9 bits (128), Expect = 5e-07
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 380 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 434
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1102
Query: 435 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 494
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 1103 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1158
Query: 495 D 495
D
Sbjct: 1159 D 1159
Score = 46.6 bits (109), Expect = 8e-05
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 677 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 726
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 539 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 597
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 714
Query: 598 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 644
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 715 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 774
Query: 645 QDREGIFPAVFVRPCPAEAKSMLAIVPK 672
Q G FP +V P+ +++ A+ PK
Sbjct: 775 QGNFGWFPCNYVEKMPS-SENEKAVSPK 801
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 125 bits (314), Expect = 1e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 427 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 486
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
Query: 487 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 534
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
Query: 535 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 594
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
Query: 595 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 649
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
Query: 650 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 708
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
Query: 709 MSGELMGKSGIFPKNYIQ 726
GE+ G +G+FP NY++
Sbjct: 1165 WQGEINGVTGLFPSNYVK 1182
Score = 92.8 bits (229), Expect = 1e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 297 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 352
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
Query: 353 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 391
F V P P H + + + D++ +L+Q EN
Sbjct: 876 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 933
Query: 392 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 446
+ G G S +KII P E R P A + A ++V L+
Sbjct: 934 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 991
Query: 447 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 506
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 992 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1049
Query: 507 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 561
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 1050 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1107
Query: 562 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 618
P + V+ P + T + + + A++ + A
Sbjct: 1108 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1143
Query: 619 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 657
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 1144 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
Score = 78.6 bits (192), Expect = 2e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 423 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 477
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 1035 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1094
Query: 478 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 532
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 1095 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1147
Query: 533 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 587
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 1148 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1207
Query: 588 TKKE 591
K++
Sbjct: 1208 RKRQ 1211
Score = 73.6 bits (179), Expect = 6e-13
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 444 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 501
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
Query: 502 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 557
K ++ + V S E + + + VN W + R
Sbjct: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
Query: 558 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 617
T + P V P+ G V +L A +AL S+TA+
Sbjct: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
Query: 618 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 671
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
Query: 672 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 722
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
Query: 723 NYIQ 726
NY++
Sbjct: 1032 NYVK 1035
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 576
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
Query: 577 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 636
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
Query: 637 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 696
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
Query: 697 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
Score = 53.9 bits (128), Expect = 5e-07
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 380 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 434
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1129
Query: 435 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 494
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 1130 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1185
Query: 495 D 495
D
Sbjct: 1186 D 1186
Score = 46.6 bits (109), Expect = 8e-05
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 677 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 726
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 539 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 597
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
Query: 598 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 644
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
Query: 645 QDREGIFPAVFVRPCPAEAKSMLAIVPK 672
Q G FP +V P+ +++ A+ PK
Sbjct: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 125 bits (314), Expect = 1e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 427 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 486
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
Query: 487 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 534
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
Query: 535 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 594
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
Query: 595 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 649
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
Query: 650 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 708
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
Query: 709 MSGELMGKSGIFPKNYIQ 726
GE+ G +G+FP NY++
Sbjct: 1165 WQGEINGVTGLFPSNYVK 1182
Score = 92.8 bits (229), Expect = 1e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 297 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 352
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
Query: 353 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 391
F V P P H + + + D++ +L+Q EN
Sbjct: 876 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 933
Query: 392 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 446
+ G G S +KII P E R P A + A ++V L+
Sbjct: 934 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 991
Query: 447 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 506
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 992 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1049
Query: 507 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 561
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 1050 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1107
Query: 562 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 618
P + V+ P + T + + + A++ + A
Sbjct: 1108 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1143
Query: 619 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 657
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 1144 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
Score = 78.6 bits (192), Expect = 2e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 423 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 477
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 1035 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1094
Query: 478 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 532
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 1095 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1147
Query: 533 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 587
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 1148 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1207
Query: 588 TKKE 591
K++
Sbjct: 1208 RKRQ 1211
Score = 73.6 bits (179), Expect = 6e-13
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 444 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 501
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
Query: 502 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 557
K ++ + V S E + + + VN W + R
Sbjct: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
Query: 558 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 617
T + P V P+ G V +L A +AL S+TA+
Sbjct: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
Query: 618 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 671
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
Query: 672 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 722
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
Query: 723 NYIQ 726
NY++
Sbjct: 1032 NYVK 1035
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 576
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
Query: 577 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 636
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
Query: 637 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 696
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
Query: 697 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
Score = 53.9 bits (128), Expect = 5e-07
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 380 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 434
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1129
Query: 435 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 494
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 1130 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1185
Query: 495 D 495
D
Sbjct: 1186 D 1186
Score = 46.6 bits (109), Expect = 8e-05
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 677 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 726
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 539 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 597
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
Query: 598 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 644
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
Query: 645 QDREGIFPAVFVRPCPAEAKSMLAIVPK 672
Q G FP +V P+ +++ A+ PK
Sbjct: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 115 bits (289), Expect = 1e-25
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 45/312 (14%)
Query: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII------ 494
A L+ + A++ + LN +++ +LE+ D W+ G + Q G FP +YVK+I
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 495 --------DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 546
+ P + V G +A + Y ++ +L+F +G++I++ + +
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-D 1035
Query: 547 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 606
+W G V + G+FP N+V ++D SG +G + P E
Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVR-LKDSEGSGT---------------AGKTGSLGKKP-EI 1078
Query: 607 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE-----GIFPAVFVRPC-P 660
+ + S+TA + L+ G I I ++ W G LQ R G FPA +V+ P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 661 AEAKSMLAIVPKGRKAKA------LYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 714
+K PK A +YD+ +N+DEL+F G II L D DW GE+
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 715 GKSGIFPKNYIQ 726
G+ G+FP NY++
Sbjct: 1199 GQVGLFPSNYVK 1210
Score = 83.6 bits (205), Expect = 6e-16
Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILK-EYVNEE------WARGEVRGRTGIFPLNFVE--PV 569
A + + DE++ G+I+++K E+V+E W GE++G+TG FP N+ E P
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPE 806
Query: 570 EDYP------TSGANVLSTKVPLK-TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLS 622
+ P T + + K+ L+ T + ++S+ ++ P W + ++ T++
Sbjct: 807 NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPE 866
Query: 623 FKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDF 682
D L G+L+ R PA P+ V +G +A+ALY +
Sbjct: 867 TDNWDAWAAQPSLTVP-SAGQLRQRSAFTPATATGSSPSPVLGQGEKV-EGLQAQALYPW 924
Query: 683 RGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
R + ++ L+F D+IT LE D W GE+ G+ G FPK+Y++ +
Sbjct: 925 RAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI 969
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 512 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 571
V+G + A + + ++ + L+F++ ++I + E + W GEV+G+ G FP ++V+ +
Sbjct: 913 VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISG 971
Query: 572 --YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRI 629
++ + S++ P K+ S + V S E A++++ + DL+F++GD I
Sbjct: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVS--GEEFIAMYTYESSEQGDLTFQQGDVI 1029
Query: 630 QILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML----AIVPKGRKAKALYDFRGE 685
+ ++ D DW G + D+ G+FP+ +VR +E ++ K A+ + +
Sbjct: 1030 LVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTAT 1088
Query: 686 NEDELSFKAGDIITELESVDDDWMSGELMGKS-----GIFPKNYIQFL 728
++L+ G +I + W GEL + G FP NY++ L
Sbjct: 1089 GPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 72.0 bits (175), Expect = 2e-12
Identities = 40/140 (28%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
Query: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIID 495
A V+ + A + L L G+++ + +K W+ G + QIG FPANYVK++
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 496 IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR 555
S+ + + ++Y + DEL+F++G+II + + +W +GEV
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 556 GRTGIFPLNFVEPVEDYPTS 575
G+ G+FP N+V+ D S
Sbjct: 1199 GQVGLFPSNYVKLTTDMDPS 1218
Score = 64.3 bits (155), Expect = 4e-10
Identities = 73/318 (22%), Positives = 126/318 (39%), Gaps = 53/318 (16%)
Query: 445 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNG 502
HD Q D+ + GE V + + W G + + G FPANY + I ++P
Sbjct: 756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKP 815
Query: 503 KRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWA--------RGEV 554
+ S+ K + + E L+ + E WA
Sbjct: 816 VTDSTSAPAPKLA--------LRETPAPLAVTSSE----PSTTPNNWADFSSTWPTSTNE 863
Query: 555 RGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGS-----NSQVNSLPAEWCEA 609
+ T + +P P++G + T S S +V L A+ A
Sbjct: 864 KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQ---A 920
Query: 610 LHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR------------ 657
L+ + A+ + L+F + D I +LE+ D W G +Q ++G FP +V+
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKSTSM 979
Query: 658 -----PCPAEAKSMLAIVPK----GRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 708
PA K + + K G + A+Y + + +L+F+ GD+I + D DW
Sbjct: 980 DSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVIL-VTKKDGDW 1038
Query: 709 MSGELMGKSGIFPKNYIQ 726
+G + K+G+FP NY++
Sbjct: 1039 WTGTVGDKAGVFPSNYVR 1056
Score = 46.6 bits (109), Expect = 8e-05
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 642 GRL--QDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA---KALYDFRGENEDELSFKAGD 696
GRL Q +E PAV AE + + K +ALY F + DE++ + GD
Sbjct: 706 GRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGD 765
Query: 697 IIT-------ELESVDDDWMSGELMGKSGIFPKNYIQ 726
I+ E ++ + W+ GEL GK+G FP NY +
Sbjct: 766 IVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 115 bits (289), Expect = 1e-25
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 45/312 (14%)
Query: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII------ 494
A L+ + A++ + LN +++ +LE+ D W+ G + Q G FP +YVK+I
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 495 --------DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 546
+ P + V G +A + Y ++ +L+F +G++I++ + +
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-D 1035
Query: 547 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 606
+W G V + G+FP N+V ++D SG +G + P E
Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVR-LKDSEGSGT---------------AGKTGSLGKKP-EI 1078
Query: 607 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE-----GIFPAVFVRPC-P 660
+ + S+TA + L+ G I I ++ W G LQ R G FPA +V+ P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 661 AEAKSMLAIVPKGRKAKA------LYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 714
+K PK A +YD+ +N+DEL+F G II L D DW GE+
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 715 GKSGIFPKNYIQ 726
G+ G+FP NY++
Sbjct: 1199 GQVGLFPSNYVK 1210
Score = 83.6 bits (205), Expect = 6e-16
Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILK-EYVNEE------WARGEVRGRTGIFPLNFVE--PV 569
A + + DE++ G+I+++K E+V+E W GE++G+TG FP N+ E P
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPE 806
Query: 570 EDYP------TSGANVLSTKVPLK-TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLS 622
+ P T + + K+ L+ T + ++S+ ++ P W + ++ T++
Sbjct: 807 NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPE 866
Query: 623 FKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDF 682
D L G+L+ R PA P+ V +G +A+ALY +
Sbjct: 867 TDNWDAWAAQPSLTVP-SAGQLRQRSAFTPATATGSSPSPVLGQGEKV-EGLQAQALYPW 924
Query: 683 RGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
R + ++ L+F D+IT LE D W GE+ G+ G FPK+Y++ +
Sbjct: 925 RAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI 969
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 512 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 571
V+G + A + + ++ + L+F++ ++I + E + W GEV+G+ G FP ++V+ +
Sbjct: 913 VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISG 971
Query: 572 --YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRI 629
++ + S++ P K+ S + V S E A++++ + DL+F++GD I
Sbjct: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVS--GEEFIAMYTYESSEQGDLTFQQGDVI 1029
Query: 630 QILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML----AIVPKGRKAKALYDFRGE 685
+ ++ D DW G + D+ G+FP+ +VR +E ++ K A+ + +
Sbjct: 1030 LVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTAT 1088
Query: 686 NEDELSFKAGDIITELESVDDDWMSGELMGKS-----GIFPKNYIQFL 728
++L+ G +I + W GEL + G FP NY++ L
Sbjct: 1089 GPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 72.0 bits (175), Expect = 2e-12
Identities = 40/140 (28%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
Query: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIID 495
A V+ + A + L L G+++ + +K W+ G + QIG FPANYVK++
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 496 IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR 555
S+ + + ++Y + DEL+F++G+II + + +W +GEV
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 556 GRTGIFPLNFVEPVEDYPTS 575
G+ G+FP N+V+ D S
Sbjct: 1199 GQVGLFPSNYVKLTTDMDPS 1218
Score = 64.3 bits (155), Expect = 4e-10
Identities = 73/318 (22%), Positives = 126/318 (39%), Gaps = 53/318 (16%)
Query: 445 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNG 502
HD Q D+ + GE V + + W G + + G FPANY + I ++P
Sbjct: 756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKP 815
Query: 503 KRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWA--------RGEV 554
+ S+ K + + E L+ + E WA
Sbjct: 816 VTDSTSAPAPKLA--------LRETPAPLAVTSSE----PSTTPNNWADFSSTWPTSTNE 863
Query: 555 RGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGS-----NSQVNSLPAEWCEA 609
+ T + +P P++G + T S S +V L A+ A
Sbjct: 864 KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQ---A 920
Query: 610 LHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR------------ 657
L+ + A+ + L+F + D I +LE+ D W G +Q ++G FP +V+
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKSTSM 979
Query: 658 -----PCPAEAKSMLAIVPK----GRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 708
PA K + + K G + A+Y + + +L+F+ GD+I + D DW
Sbjct: 980 DSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVIL-VTKKDGDW 1038
Query: 709 MSGELMGKSGIFPKNYIQ 726
+G + K+G+FP NY++
Sbjct: 1039 WTGTVGDKAGVFPSNYVR 1056
Score = 46.6 bits (109), Expect = 8e-05
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 642 GRL--QDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA---KALYDFRGENEDELSFKAGD 696
GRL Q +E PAV AE + + K +ALY F + DE++ + GD
Sbjct: 706 GRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGD 765
Query: 697 IIT-------ELESVDDDWMSGELMGKSGIFPKNYIQ 726
I+ E ++ + W+ GEL GK+G FP NY +
Sbjct: 766 IVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 113 bits (282), Expect = 7e-25
Identities = 139/557 (24%), Positives = 222/557 (39%), Gaps = 74/557 (13%)
Query: 128 SSDSGKKVPTPAPRPLLLKKSVSSENPTYP-SAPLKPVTVPPRLAGASQAKAYKSLGEGP 186
S+ S T RPL S +S N S+P+ P VPP + P
Sbjct: 313 SAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV---------------P 357
Query: 187 PANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLGLHEDPQSPPPLPAE 246
P P K D D + ++ E G +L HE PPPLP
Sbjct: 358 PLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ-HE---RPPPLP-- 411
Query: 247 KPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKV 306
T + + L S+ G+ G PPR +G P+ + P +
Sbjct: 412 --------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR------SGAPTPSSRAPA-L 456
Query: 307 PPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQSNLATGLSKAKSQVFKNQDP 361
P RPP L + + + FN +SS D L++ S+ + K + K++
Sbjct: 457 SPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMSSASMASDFRKRR--KSEPA 513
Query: 362 VLPPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDE 418
V PPR G S+ G V + T++ + S + L +
Sbjct: 514 VGPPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTD 572
Query: 419 HLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC 478
RS P + P P A ++DF A+ +L+ G+ VY+L KID +WY G
Sbjct: 573 MGRSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 629
Query: 479 RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEI 538
++GIFP +YV+ + PE R + + +A++ + + ELS +G+
Sbjct: 630 HGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 688
Query: 539 IILKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------EDYPT-------SGANVLST 582
+IL + V++ W G++ G R GIFP+++VE V EDYP S + S
Sbjct: 689 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 748
Query: 583 KVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG 642
+ + N Q P +AL+++T D+L + D I ++E+ D W G
Sbjct: 749 SSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVG 805
Query: 643 RLQDRE--GIFPAVFVR 657
+ + G FP +V+
Sbjct: 806 TSRRTKFFGTFPGNYVK 822
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 486 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 545
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 563 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 620
Query: 546 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 605
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 621 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 663
Query: 606 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 661
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 664 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 723
Query: 662 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 689
K S+ + P+ G +ALY++ NEDE
Sbjct: 724 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 783
Query: 690 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 728
L + D+I +E DD W G G FP NY++ L
Sbjct: 784 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 590 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 646
Query: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 647 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 706
Query: 716 --KSGIFPKNYIQFLQ 729
+ GIFP +Y++ ++
Sbjct: 707 TNRQGIFPVSYVEVVK 722
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 113 bits (282), Expect = 7e-25
Identities = 139/557 (24%), Positives = 222/557 (39%), Gaps = 74/557 (13%)
Query: 128 SSDSGKKVPTPAPRPLLLKKSVSSENPTYP-SAPLKPVTVPPRLAGASQAKAYKSLGEGP 186
S+ S T RPL S +S N S+P+ P VPP + P
Sbjct: 220 SAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV---------------P 264
Query: 187 PANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLGLHEDPQSPPPLPAE 246
P P K D D + ++ E G +L HE PPPLP
Sbjct: 265 PLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQ-HE---RPPPLP-- 318
Query: 247 KPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKV 306
T + + L S+ G+ G PPR +G P+ + P +
Sbjct: 319 --------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR------SGAPTPSSRAPA-L 363
Query: 307 PPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQSNLATGLSKAKSQVFKNQDP 361
P RPP L + + + FN +SS D L++ S+ + K + K++
Sbjct: 364 SPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMSSASMASDFRKRR--KSEPA 420
Query: 362 VLPPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDE 418
V PPR G S+ G V + T++ + S + L +
Sbjct: 421 VGPPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTD 479
Query: 419 HLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC 478
RS P + P P A ++DF A+ +L+ G+ VY+L KID +WY G
Sbjct: 480 MGRSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH 536
Query: 479 RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEI 538
++GIFP +YV+ + PE R + + +A++ + + ELS +G+
Sbjct: 537 HGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 595
Query: 539 IILKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------EDYPT-------SGANVLST 582
+IL + V++ W G++ G R GIFP+++VE V EDYP S + S
Sbjct: 596 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSL 655
Query: 583 KVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG 642
+ + N Q P +AL+++T D+L + D I ++E+ D W G
Sbjct: 656 SSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVG 712
Query: 643 RLQDRE--GIFPAVFVR 657
+ + G FP +V+
Sbjct: 713 TSRRTKFFGTFPGNYVK 729
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 486 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 545
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 470 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 527
Query: 546 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 605
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 528 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 570
Query: 606 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 661
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 571 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 630
Query: 662 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 689
K S+ + P+ G +ALY++ NEDE
Sbjct: 631 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 690
Query: 690 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 728
L + D+I +E DD W G G FP NY++ L
Sbjct: 691 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 497 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 553
Query: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 554 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 613
Query: 716 --KSGIFPKNYIQFLQ 729
+ GIFP +Y++ ++
Sbjct: 614 TNRQGIFPVSYVEVVK 629
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 107 bits (267), Expect = 4e-23
Identities = 154/701 (21%), Positives = 268/701 (38%), Gaps = 99/701 (14%)
Query: 49 SSGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPN 108
S+ +P V P + GT G P P + + P+T P L
Sbjct: 121 SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP 180
Query: 109 PGLIRSVNPEIPGRG-----PLAESSDSGKKVPT---PAPRPL--LLKKSVSSENPTYPS 158
P L R + P R P++++ S P PAP L + + ++ + S
Sbjct: 181 PHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDS 240
Query: 159 APLKPVTVPPRLAGASQAKAYKSLGEGPPA-------NPPVPVLQSKPLVDIDLISFDDD 211
+PL V L G + ++A+ S+ + A NP + +LQ L S D
Sbjct: 241 SPLLN-EVSSSLIG-TDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDP 298
Query: 212 VL---------------PTPSGNLAEESV--GSEMVLGLHEDPQSPPPLPAEKPIGNT-- 252
V PT G E+ S V+ +D P+ NT
Sbjct: 299 VSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTER 358
Query: 253 ----FSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPP 308
+ T+ ++ + R + + P + P PR + + + K
Sbjct: 359 SKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSA 418
Query: 309 ERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT--GLSKAKSQVFKNQ--DPVLP 364
P P + S+ + S+++ + +D +K ++ + KS V N+ +
Sbjct: 419 TLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAIS 478
Query: 365 PRPK-----PGHPLYSKYMR---------GDVLVMLKQTENNYLECQKGEDTGRVHLSQM 410
P P+ PG+ S + GD L L+ Y +G D LS +
Sbjct: 479 PTPEISSETPGYIYSSNFHAVKRESDGAPGD-LTSLENERQIYKSVLEGGDIPLQGLSGL 537
Query: 411 KIITPLDEHLRSRPNDPSH--------------AQKPVDSGAPHAVVLHDFPAEQVDDLN 456
K P P H ++ D A DF A+ + +L
Sbjct: 538 K--RPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELP 595
Query: 457 LTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSR 516
L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++ ++
Sbjct: 596 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKKLTPVQVLEYGE 653
Query: 517 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPVE---- 570
+A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+ +V+ ++
Sbjct: 654 AIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLV 713
Query: 571 -------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSD 619
D P S + S + P ++ + SQ + + +AL+S+ + D
Sbjct: 714 KNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-QALYSYIPQNDD 772
Query: 620 DLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 658
+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 773 ELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 813
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 582 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 633
Query: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 634 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 685
Query: 639 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 677
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 686 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 745
Query: 678 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 719
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 746 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 805
Query: 720 FPKNYIQFLQI 730
FP NY++ L +
Sbjct: 806 FPGNYVKPLYL 816
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 598 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 652
Query: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 493
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 653 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 711
Query: 494 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 528
+D+P + R +S V R A + YI +
Sbjct: 712 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 771
Query: 529 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 772 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/55 (40%), Positives = 34/55 (61%)
Query: 674 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
R A+A +DF+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 578 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 632
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 509 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 566
Query: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 567 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 626
Query: 564 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 608
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 627 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 685
Query: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 658
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 686 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 737
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 557
Query: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 558 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 609
Query: 639 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 677
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 610 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 669
Query: 678 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 719
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 670 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 729
Query: 720 FPKNYIQFLQI 730
FP NY++ L +
Sbjct: 730 FPGNYVKPLYL 740
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 522 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 576
Query: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 493
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 577 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 635
Query: 494 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 528
+D+P + R +S V R A + YI +
Sbjct: 636 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 695
Query: 529 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 696 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 52.4 bits (124), Expect = 1e-06
Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 15/167 (8%)
Query: 571 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQ 630
D P G + L + K+ S S + +PA++ E+ F DD D+ +
Sbjct: 396 DIPLQGLSGLKRPSSSASTKD---SESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 452
Query: 631 IL-ERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRK--------AKALYD 681
+ E+ ++D R G+ P +L I ++ A+A +D
Sbjct: 453 LKREQEEADIAARR---HTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 509
Query: 682 FRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
F+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 510 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 556
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 550 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 607
Query: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 608 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 667
Query: 564 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 608
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 668 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 726
Query: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 658
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 727 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 778
Score = 91.7 bits (226), Expect = 2e-18
Identities = 168/806 (20%), Positives = 295/806 (36%), Gaps = 149/806 (18%)
Query: 14 VSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAAN---RASGEWDS 70
+S +K+ +T SGL + P + P + +GK +V + +++ S S
Sbjct: 36 ISAVKIIPVKTVKNASGL-----VLPTDMDPTK-ICTGKGAVTLRASSSYRETPSSSPAS 89
Query: 71 GTENRLKVTSKEGLTPYPPLQE----AGSIPVTKPELPKKPNPGLIRSVNPEIPG----- 121
E R + SK GL P P + + S P RSV+P +P
Sbjct: 90 PQETR-QHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD 148
Query: 122 RGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKS 181
PL S P SVS + YPS + T+ Q K S
Sbjct: 149 SSPLLNEVSSSLIGTDSQAFP-----SVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSS 203
Query: 182 LGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESV--GSEMVLGLHEDPQS 239
L + P + V S P + PT G E+ S V+ +D
Sbjct: 204 LSD-PVSERRVGEQDSAPTQE----------KPTSPGKAIEKRAKDDSRRVVKSTQDLSD 252
Query: 240 PPPLPAEKPIGNT------FSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVN 293
P+ NT + T+ ++ + R + + P + P PR +
Sbjct: 253 VSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKS 312
Query: 294 GKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT--GLSKA 351
+ + K P P + S+ + S+++ + +D +K ++ +
Sbjct: 313 EMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 372
Query: 352 KSQVFKNQ--DPVLPPRPK-----PGHPLYSKYMR---------GDVLVMLKQTENNYLE 395
KS V N+ + P P+ PG+ S + GD L L+ Y
Sbjct: 373 KSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGD-LTSLENERQIYKS 431
Query: 396 CQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDL 455
+G D LS +K PS + DS +P + D+ + +
Sbjct: 432 VLEGGDIPLQGLSGLK--------------RPSSSASTKDSESPRHFIPADYLESTEEFI 477
Query: 456 NLTSGEIVYLLE-----KIDTDWYRGNCRNQIGIFPANYVKV-------IIDIPEGGNGK 503
+ LL K + + R G+ P ++ + +++I + K
Sbjct: 478 RRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRK 537
Query: 504 RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPL 563
S ++ +R A+F++ + EL +G+I+ + + +++ W GE GR GIFP
Sbjct: 538 ----SGSEMRPAR--AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPR 591
Query: 564 NFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 623
++E + +K + V L A +F +T ++SF
Sbjct: 592 TYIELLP----------------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSF 635
Query: 624 KRGDRIQILERLDSDWCRGRL--QDREGIFPAVFV----RP---------------CPAE 662
++G+RI +L ++D +W GR+ R+GIFP +V RP P+
Sbjct: 636 RKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 695
Query: 663 AKSMLAIVPKGRKAK----------------ALYDFRGENEDELSFKAGDIITELESVDD 706
+ + P+ ++ + ALY + +N+DEL + GDI+ +E DD
Sbjct: 696 SATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDD 755
Query: 707 DWMSG--ELMGKSGIFPKNYIQFLQI 730
W G + G FP NY++ L +
Sbjct: 756 GWFVGTSRRTKQFGTFPGNYVKPLYL 781
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 453 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 510
Query: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 511 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 570
Query: 564 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 608
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 571 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 629
Query: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 658
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 630 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 681
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 450 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 501
Query: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 502 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 553
Query: 639 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 677
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 554 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 613
Query: 678 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 719
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 614 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 673
Query: 720 FPKNYIQFLQI 730
FP NY++ L +
Sbjct: 674 FPGNYVKPLYL 684
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 466 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 520
Query: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 493
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 521 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 579
Query: 494 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 528
+D+P + R +S V R A + YI +
Sbjct: 580 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 639
Query: 529 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 640 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/55 (40%), Positives = 34/55 (61%)
Query: 674 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
R A+A +DF+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 446 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 500
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 105 bits (263), Expect = 1e-22
Identities = 115/459 (25%), Positives = 194/459 (42%), Gaps = 49/459 (10%)
Query: 237 PQSPPPLPAEKPIGNTFSTVSGKLSNVER---TRNLESN-------HPGQTGGFVRVPP- 285
P PPP+P +P + ST +R TR S PG++ P
Sbjct: 217 PHVPPPVPPLRPRDRS-STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPT 275
Query: 286 -RLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQK 339
R+ P ++ + P + +++ RPPP K + + FN +SS D L++
Sbjct: 276 DRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLER 335
Query: 340 KQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLEC 396
S+ + K + K++ V PPR G S+ G V + T++
Sbjct: 336 PMSSASMASDFRKRR--KSEPAVGPPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSS 392
Query: 397 QKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLN 456
+ S + L + RS P + P P A ++DF A+ +L+
Sbjct: 393 PSSPSRAKDRESPRSYSSTLTDMGRSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELS 449
Query: 457 LTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSR 516
G+ VY+L KID +WY G ++GIFP +YV+ + PE R + +
Sbjct: 450 FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGE 508
Query: 517 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPV----- 569
+A++ + + ELS +G+ +IL + V++ W G++ G R GIFP+++VE V
Sbjct: 509 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 568
Query: 570 --EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDD 620
EDYP S + S + + N Q P +AL+++T D+
Sbjct: 569 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDE 625
Query: 621 LSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 657
L + D I ++E+ D W G + + G FP +V+
Sbjct: 626 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 664
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 486 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 545
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 405 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 462
Query: 546 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 605
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 463 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 505
Query: 606 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 661
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 506 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 565
Query: 662 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 689
K S+ + P+ G +ALY++ NEDE
Sbjct: 566 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 625
Query: 690 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 728
L + D+I +E DD W G G FP NY++ L
Sbjct: 626 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 432 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 488
Query: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 489 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 548
Query: 716 --KSGIFPKNYIQFLQ 729
+ GIFP +Y++ ++
Sbjct: 549 TNRQGIFPVSYVEVVK 564
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 105 bits (262), Expect = 1e-22
Identities = 112/445 (25%), Positives = 175/445 (39%), Gaps = 51/445 (11%)
Query: 300 QQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQ 359
++P P E+P P R +L +L K + T L KS +
Sbjct: 256 KKPLVDDPGEKPSQPIEVLLERELAEL-------SAELDKDLRAIETRLPSPKSSPAPRR 308
Query: 360 DPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEH 419
P P P S Y L + L K D G L + + P
Sbjct: 309 APEQRPPAGPASAWSSSYPHAPYLGSARS-----LSPHKMADGGSPFLGRRDFVYPSSTR 363
Query: 420 LRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR 479
S N + + A + DF A+ +L L G+IVY+ +++D +W G
Sbjct: 364 DPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHH 423
Query: 480 NQIGIFPANYVKVI--IDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGE 537
++GIFPANYV+V+ +IP+ + + ++ VA++ + G+ + ELSF +GE
Sbjct: 424 GRLGIFPANYVEVLPADEIPK----PIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGE 479
Query: 538 IIILKEYVNEEWARGEV--RGRTGIFPLNFV----EP----VEDYPTSGANVLSTKVPLK 587
I L VNE W G + GR GIFP ++V EP +D P + T
Sbjct: 480 HICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARS 539
Query: 588 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 647
+ S S + + P + L T+ SF + R + Q+
Sbjct: 540 ARHPSSPSALRSPADPID----LGGQTSPRRTGFSFPTQEP------------RPQTQNL 583
Query: 648 EGIFPAVFVRPCPAEAKSMLAIVPKGRKA-----KALYDFRGENEDELSFKAGDIITELE 702
PA+ P+ + P + +A+Y +R +NEDEL + GD + ++
Sbjct: 584 GTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQ 643
Query: 703 SVDDDWMSG--ELMGKSGIFPKNYI 725
DD W G K G FP NY+
Sbjct: 644 QCDDGWFVGVSRRTQKFGTFPGNYV 668
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 613 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 667
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 391 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 450
Query: 668 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 725
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 451 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 510
Query: 726 Q 726
Q
Sbjct: 511 Q 511
Score = 66.2 bits (160), Expect = 1e-10
Identities = 106/482 (21%), Positives = 175/482 (36%), Gaps = 78/482 (16%)
Query: 210 DDVLPTPSGN--LAEESVGSEMVLGLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTR 267
D+V S N L E G L +DP P P E + + +S +L R
Sbjct: 234 DNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRA- 292
Query: 268 NLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQP-PTKVPPERPPPPKLSATRRSNKKL 326
+ RLP P P P + P +RPP SA S
Sbjct: 293 ---------------IETRLPS--------PKSSPAPRRAPEQRPPAGPASAWSSSYPHA 329
Query: 327 PFNRSSSDMDLQKKQSNLAT---------------------GLSKAKSQVFKNQDPVLPP 365
P+ S+ + K + G S A+ + K + L
Sbjct: 330 PYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKF 389
Query: 366 RPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPN 425
+ P +GD++ + K+ + N+LE GE GR+ + + L +P
Sbjct: 390 DFQAQSPKELTLQKGDIVYIHKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPI 446
Query: 426 DPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN--QIG 483
P Q ++ G AV + F + +L+ GE + L+ K++ +WY G + G
Sbjct: 447 KPPTYQV-LEYG--EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQG 503
Query: 484 IFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKE 543
IFPA+YV+V RE C G + + S L+
Sbjct: 504 IFPASYVQV----------SREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRS 551
Query: 544 YVNEEWARGEVRGRTGIFPLNFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVN 600
+ G+ R F EP ++ T G + ++ P + D G++S N
Sbjct: 552 PADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-N 608
Query: 601 SLPAEWC--EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFV 656
+ W A++ + + D+L + GDR+ ++++ D W G R + G FP +V
Sbjct: 609 TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Query: 657 RP 658
P
Sbjct: 669 AP 670
Score = 52.4 bits (124), Expect = 1e-06
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 672 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 381 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 437
Score = 32.7 bits (73), Expect = 1.2
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 105 bits (261), Expect = 2e-22
Identities = 80/327 (24%), Positives = 140/327 (42%), Gaps = 43/327 (13%)
Query: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV---------- 490
A+V D+ A+ D+L ++ GEI+ + K D W+ G + G+FP N+V
Sbjct: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
Query: 491 --------KVIIDIPEGGNGKRECVSSHCV---------KGSRCVARFEYIGEQKDELSF 533
K + ++P G + +SS + + RC F Y+ + DEL
Sbjct: 64 PLTNKAPEKPLHEVPSGNS----LLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELEL 119
Query: 534 SEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDS 593
G+II + V E W G + G+TG+FP NF++ + ++ + +E +
Sbjct: 120 KVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETT 179
Query: 594 GSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPA 653
GS S + E + A + +G + + R R + E F
Sbjct: 180 GSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLP 239
Query: 654 V---------FVRPCPAEAKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDIITEL-- 701
V P +K+ + K + K ++ + +N+DEL+ K GDI+T +
Sbjct: 240 VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINK 299
Query: 702 ESVDDDWMSGELMGKSGIFPKNYIQFL 728
+ +D W GEL G+ G+FP N+++ L
Sbjct: 300 DCIDVGWWEGELNGRRGVFPDNFVKLL 326
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/227 (22%), Positives = 99/227 (43%), Gaps = 29/227 (12%)
Query: 453 DDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII-DIPEGGNGKRECVSSHC 511
D+L L G+I+ ++ +++ W+ G + G+FP+N++K + + E G + E +S
Sbjct: 115 DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSS 174
Query: 512 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR----TGIFPLNFVE 567
++ E G + D S + E N A ++ + G + +
Sbjct: 175 LR--------ETTGSESDGGDSSSTK----SEGANGTVATAAIQPKKVKGVGFGDIFKDK 222
Query: 568 PVEDYPTS---------GANVLSTKVPLKTKKEDSGSNSQVNSLPA-EWCEALHSFTAET 617
P++ P S + K+P T DS + + ++C+ + + A+
Sbjct: 223 PIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQN 282
Query: 618 SDDLSFKRGDRIQILER--LDSDWCRGRLQDREGIFPAVFVRPCPAE 662
D+L+ K GD + ++ + +D W G L R G+FP FV+ P +
Sbjct: 283 DDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPD 329
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/107 (30%), Positives = 52/107 (48%), Gaps = 7/107 (6%)
Query: 517 CVARFEYIGEQKDELSFSEGEIIIL--KEYVNEEWARGEVRGRTGIFPLNFVEPV-EDYP 573
C F Y + DEL+ EG+I+ L K+ ++ W GE+ GR G+FP NFV+ + D+
Sbjct: 272 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFE 331
Query: 574 TSGANVLSTKVP-LKTKKEDSGSNS---QVNSLPAEWCEALHSFTAE 616
G P K+ +G+ ++ +P E E L + T E
Sbjct: 332 KEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEE 378
Score = 43.9 bits (102), Expect = 5e-04
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 6/81 (7%)
Query: 427 PSHAQKPVDS---GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEK--IDTDWYRGNCRNQ 481
P ++ +DS + V+ + A+ D+L + G+IV L+ K ID W+ G +
Sbjct: 255 PDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR 314
Query: 482 IGIFPANYVKVI-IDIPEGGN 501
G+FP N+VK++ D + GN
Sbjct: 315 RGVFPDNFVKLLPPDFEKEGN 335
Score = 30.8 bits (68), Expect = 4.7
Identities = 41/165 (24%), Positives = 62/165 (37%), Gaps = 24/165 (14%)
Query: 214 PTPSGNLAEESVGSEMVLGLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNH 273
P PS + ++ G+ HE + PP P P + + ER L+
Sbjct: 341 PPPSAPVIKQGAGTTE--RKHEIKKIPPERPEMLP------NRTEEKERPEREPKLDLQK 392
Query: 274 PGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPP--KLSATRRSNKKLPFNRS 331
P +PP+ P P KT +P +PP RP P L+ TR + K+ S
Sbjct: 393 PSVPA----IPPKKPRPP---KTNSLSRPGA-LPPRRPERPVGPLTHTRGDSPKIDLAGS 444
Query: 332 SSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSK 376
S L K S+ + + + D V+ K HP S+
Sbjct: 445 SLSGILDKDLSDRSNDID------LEGFDSVVSSTEKLSHPTTSR 483
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 103 bits (258), Expect = 4e-22
Identities = 98/375 (26%), Positives = 163/375 (43%), Gaps = 36/375 (9%)
Query: 309 ERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVL 363
ERPPP K + + FN +SS D L++ S+ + K + K++ V
Sbjct: 295 ERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR--KSEPAVG 352
Query: 364 PPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL 420
PPR G S+ G V + T++ + S + L +
Sbjct: 353 PPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMG 411
Query: 421 RSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN 480
RS P + P P A ++DF A+ +L+ G+ VY+L KID +WY G
Sbjct: 412 RSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHG 468
Query: 481 QIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIII 540
++GIFP +YV+ + PE R + + +A++ + + ELS +G+ +I
Sbjct: 469 RVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVI 527
Query: 541 LKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKV 584
L + V++ W G++ G R GIFP+++VE V EDYP S + S
Sbjct: 528 LLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSS 587
Query: 585 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRL 644
+ + N Q P +AL+++T D+L + D I ++E+ D W G
Sbjct: 588 NKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 644
Query: 645 QDRE--GIFPAVFVR 657
+ + G FP +V+
Sbjct: 645 RRTKFFGTFPGNYVK 659
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 486 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 545
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 400 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 457
Query: 546 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 605
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 458 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 500
Query: 606 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 661
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 501 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 560
Query: 662 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 689
K S+ + P+ G +ALY++ NEDE
Sbjct: 561 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 620
Query: 690 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 728
L + D+I +E DD W G G FP NY++ L
Sbjct: 621 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 427 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483
Query: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 484 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 543
Query: 716 --KSGIFPKNYIQFLQ 729
+ GIFP +Y++ ++
Sbjct: 544 TNRQGIFPVSYVEVVK 559
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 500
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 260 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 318
Query: 501 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 558
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 319 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 378
Query: 559 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 604
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 379 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 437
Query: 605 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 657
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 438 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 486 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 545
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 231 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 288
Query: 546 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 605
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 289 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 331
Query: 606 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 661
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 332 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 391
Query: 662 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 689
K S+ + P+ G +ALY++ NEDE
Sbjct: 392 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 451
Query: 690 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 728
L + D+I +E DD W G G FP NY++ L
Sbjct: 452 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 258 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314
Query: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 315 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 374
Query: 716 --KSGIFPKNYIQFLQ 729
+ GIFP +Y++ ++
Sbjct: 375 TNRQGIFPVSYVEVVK 390
Score = 72.8 bits (177), Expect = 1e-12
Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 36/221 (16%)
Query: 377 YMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 436
+ +GD + +L++ + N+ E GE GRV + + + L +++P P +P +
Sbjct: 276 FKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 332
Query: 437 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 494
G A+ ++F A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+
Sbjct: 333 G--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 390
Query: 495 DIPEGGNGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKD 529
+G + H R A + Y +D
Sbjct: 391 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 450
Query: 530 ELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 567
EL E ++I + E ++ W G R RT G FP N+V+
Sbjct: 451 ELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 490
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 500
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 772 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 830
Query: 501 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 558
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 831 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 890
Query: 559 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 604
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 891 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 949
Query: 605 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 657
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 950 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 486 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 545
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 743 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 800
Query: 546 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 605
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 801 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 843
Query: 606 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 661
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 844 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 903
Query: 662 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 689
K S+ + P+ G +ALY++ NEDE
Sbjct: 904 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 963
Query: 690 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 728
L + D+I +E DD W G G FP NY++ L
Sbjct: 964 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 770 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826
Query: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 827 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 886
Query: 716 --KSGIFPKNYIQFLQ 729
+ GIFP +Y++ ++
Sbjct: 887 TNRQGIFPVSYVEVVK 902
Score = 72.8 bits (177), Expect = 1e-12
Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 36/221 (16%)
Query: 377 YMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 436
+ +GD + +L++ + N+ E GE GRV + + + L +++P P +P +
Sbjct: 788 FKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 844
Query: 437 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 494
G A+ ++F A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+
Sbjct: 845 G--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 902
Query: 495 DIPEGGNGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKD 529
+G + H R A + Y +D
Sbjct: 903 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 962
Query: 530 ELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 567
EL E ++I + E ++ W G R RT G FP N+V+
Sbjct: 963 ELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 1002
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/96 (38%), Positives = 50/96 (52%), Gaps = 15/96 (15%)
Query: 642 GRLQDREGIFPAVFV-------RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSF 692
G LQDRE P + R P E + P+ K AKA+YDF+ + ELSF
Sbjct: 735 GALQDRES--PRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSF 788
Query: 693 KAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
K GD + L +D +W GE G+ GIFP +Y++ L
Sbjct: 789 KKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 824
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 500
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 412 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 470
Query: 501 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 558
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 471 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 530
Query: 559 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 604
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 531 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 589
Query: 605 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 657
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 590 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 486 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 545
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 383 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 440
Query: 546 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 605
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 441 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 483
Query: 606 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 661
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 484 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 543
Query: 662 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 689
K S+ + P+ G +ALY++ NEDE
Sbjct: 544 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 603
Query: 690 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 728
L + D+I +E DD W G G FP NY++ L
Sbjct: 604 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 410 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
Query: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 467 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 526
Query: 716 --KSGIFPKNYIQFLQ 729
+ GIFP +Y++ ++
Sbjct: 527 TNRQGIFPVSYVEVVK 542
Score = 75.9 bits (185), Expect = 1e-13
Identities = 113/510 (22%), Positives = 193/510 (37%), Gaps = 82/510 (16%)
Query: 117 PEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSE----------NPTY-----PSAPL 161
P PG GP+ ES + T RP K++ + NP Y P+A
Sbjct: 156 PHYPGIGPVDESGIP-TAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHPAAKT 214
Query: 162 KPVTVPPRLAGASQAKAYKSLGEG-PPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNL 220
+ + + A+K PP + P PV PL D S + P +
Sbjct: 215 QTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV---PPLRPRDRSSTEKHDWDPPDRKV 271
Query: 221 AEESVGSEMVLGLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGF 280
SE +P L E+P S++ L + ++ S+ +
Sbjct: 272 DTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKS- 330
Query: 281 VRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSAT--RRSNKKLPFNRS-SSDMDL 337
P PPR + Q ++ P R P S T + P + S + D +
Sbjct: 331 --EPAVGPPRGLG------DQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRES 382
Query: 338 QKKQSNLATGLSKAKSQVFKNQDPVLPPRPK-PGHPLYS---------KYMRGDVLVMLK 387
+ S+ T + ++ + + P + K P +Y + +GD + +L+
Sbjct: 383 PRSYSSTLTDMGRSAPRERRGT----PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 438
Query: 388 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDF 447
+ + N+ E GE GRV + + + L +++P P +P + G A+ ++F
Sbjct: 439 KIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIG--EAIAKYNF 493
Query: 448 PAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVIIDIPEGGNGKRE 505
A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+ +G +
Sbjct: 494 NADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPD 553
Query: 506 CVSSHCVKGSRC-------------------------VARFEYIGEQKDELSFSEGEIII 540
H R A + Y +DEL E ++I
Sbjct: 554 PPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVID 613
Query: 541 LKEYVNEEWARGEVRGRT---GIFPLNFVE 567
+ E ++ W G R RT G FP N+V+
Sbjct: 614 VMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 642
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 500
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 868 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 926
Query: 501 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 558
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 927 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 986
Query: 559 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 604
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 987 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 1045
Query: 605 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 657
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 1046 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 486 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 545
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 839 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 896
Query: 546 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 605
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 897 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 939
Query: 606 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 661
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 940 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 999
Query: 662 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 689
K S+ + P+ G +ALY++ NEDE
Sbjct: 1000 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 1059
Query: 690 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 728
L + D+I +E DD W G G FP NY++ L
Sbjct: 1060 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 866 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922
Query: 662 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 715
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 923 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 982
Query: 716 --KSGIFPKNYIQFLQ 729
+ GIFP +Y++ ++
Sbjct: 983 TNRQGIFPVSYVEVVK 998
Score = 72.8 bits (177), Expect = 1e-12
Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 36/221 (16%)
Query: 377 YMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 436
+ +GD + +L++ + N+ E GE GRV + + + L +++P P +P +
Sbjct: 884 FKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 940
Query: 437 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 494
G A+ ++F A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+
Sbjct: 941 G--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 998
Query: 495 DIPEGGNGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKD 529
+G + H R A + Y +D
Sbjct: 999 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 1058
Query: 530 ELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 567
EL E ++I + E ++ W G R RT G FP N+V+
Sbjct: 1059 ELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 1098
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/96 (38%), Positives = 50/96 (52%), Gaps = 15/96 (15%)
Query: 642 GRLQDREGIFPAVFV-------RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSF 692
G LQDRE P + R P E + P+ K AKA+YDF+ + ELSF
Sbjct: 831 GALQDRES--PRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSF 884
Query: 693 KAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
K GD + L +D +W GE G+ GIFP +Y++ L
Sbjct: 885 KKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 920
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 99.8 bits (247), Expect = 8e-21
Identities = 70/241 (29%), Positives = 107/241 (44%), Gaps = 25/241 (10%)
Query: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDT-DWYRGNCRNQIGIFPANYVKVIIDIPEGG 500
+VL + A++ D+L+L G++V + + W RG + G+FP V+ +IPE
Sbjct: 4 LVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQ---EIPETL 60
Query: 501 NGKRECVSSHCVKGSR-----------CVARFEYIGEQKDELSFSEGEIIILKEYVNEEW 549
G E C + C F Y EQ DEL GEI+ + + + + W
Sbjct: 61 RGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGW 120
Query: 550 ARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP------ 603
G+ G+ G FP NFVE ++ P S N V ++ S+ +S P
Sbjct: 121 WLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
Query: 604 --AEWCEALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRLQDREGIFPAVFVRPC 659
E L + E D+L+ +RGD +++L + D W G Q R G+FP FV P
Sbjct: 181 SHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPP 240
Query: 660 P 660
P
Sbjct: 241 P 241
Score = 88.2 bits (217), Expect = 2e-17
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 38/235 (16%)
Query: 523 YIGEQKDELSFSEGEIIILKEYVNEE-WARGEVRGRTGIFPLNFVEPVEDYPTSGANVLS 581
Y +++DELS + G+++ +V W RGE GR G+FP V+ + +
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 582 TKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCR 641
+ + + + P WC+ S++ E +D+L + G+ +++++ ++ W
Sbjct: 69 PRCARRR------GHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWL 122
Query: 642 GRLQDREGIFPAVFVR------------------PCPAEAKSM-----------LAIVPK 672
G+ + G FP+ FV P P + L V
Sbjct: 123 GKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSH 182
Query: 673 GRKAKALYDFRGENEDELSFKAGDIITELESVDDD--WMSGELMGKSGIFPKNYI 725
+ L+D++ E DEL+ + GD++ L +D W GE G+ G+FP N++
Sbjct: 183 PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237
Score = 60.8 bits (146), Expect = 4e-09
Identities = 37/135 (27%), Positives = 63/135 (46%), Gaps = 16/135 (11%)
Query: 610 LHSFTAETSDDLSFKRGDRIQILERLDS-DWCRGRLQDREGIFPAVFVRPCP------AE 662
L + A+ D+LS GD ++ + + + W RG R G+FP V+ P E
Sbjct: 6 LAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGE 65
Query: 663 AKSMLAIVPKGRKAK---------ALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL 713
A+ +G AK + + E DEL +AG+I+ ++ ++D W G+
Sbjct: 66 ARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKK 125
Query: 714 MGKSGIFPKNYIQFL 728
G+ G FP N+++ L
Sbjct: 126 NGQLGAFPSNFVELL 140
Score = 37.7 bits (86), Expect = 0.038
Identities = 70/332 (21%), Positives = 114/332 (34%), Gaps = 44/332 (13%)
Query: 29 SGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRASGE---WDSGTENRLKVTSKEGLT 85
+ LP ++ + P +S PS + +R SG + SG + T
Sbjct: 269 TSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQT 328
Query: 86 PYP----PLQEAGSIPVTKPELPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPR 141
P +E S PV P + + P P ++ PE P P E++ S KK+P P
Sbjct: 329 PQQRSVSSQEEEHSSPVKAPSVKRTPMPD--KTATPERP---PAPENAPSSKKIPAPDKV 383
Query: 142 PLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLV 201
P +P K +T+ + + + + K PA VP K +
Sbjct: 384 P----------------SPEKTLTLGDKASIPGNSTSGKI-----PAPDKVPT-PEKMVT 421
Query: 202 DIDLISFDDDVLPTPSGNLAEESVGSEMVLGLHEDP--QSPP----PLPAEKPIGNTFST 255
D S ++ + ++ E V + E P ++PP P P P+G+ T
Sbjct: 422 PEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPT 481
Query: 256 VSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPK 315
+ L+ + + Q F + K P+ Q P PP P
Sbjct: 482 LEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPP 541
Query: 316 LSATRRSNKKLPFNRSSSDMDLQKKQSNLATG 347
S K R D +Q+ L +G
Sbjct: 542 SSERCLGEMKCTLVRG----DSSPRQAELKSG 569
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 99.8 bits (247), Expect = 8e-21
Identities = 91/344 (26%), Positives = 146/344 (42%), Gaps = 39/344 (11%)
Query: 401 DTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSG 460
D G L + + P S N + + A + DF A+ +L L G
Sbjct: 3 DGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKG 62
Query: 461 EIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNGKRECVSSHCVKGSRCV 518
+IVY+ +++D +W G ++GIFPANYV+V+ +IP+ + + ++ V
Sbjct: 63 DIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK----PIKPPTYQVLEYGEAV 118
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFV----EP---- 568
A++ + G+ + ELSF +GE I L VNE W G + GR GIFP ++V EP
Sbjct: 119 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRL 178
Query: 569 VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDR 628
+D P + T + S S + + P + L T+ SF +
Sbjct: 179 CDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID----LGGQTSPRRTGFSFPTQEP 234
Query: 629 IQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA-----KALYDFR 683
R + Q+ PA+ P+ + P + +A+Y +R
Sbjct: 235 ------------RPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYR 282
Query: 684 GENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYI 725
+NEDEL + GD + ++ DD W G K G FP NY+
Sbjct: 283 PQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 613 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 667
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 49 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 108
Query: 668 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 725
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 109 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 168
Query: 726 Q 726
Q
Sbjct: 169 Q 169
Score = 62.4 bits (150), Expect = 1e-09
Identities = 68/289 (23%), Positives = 120/289 (41%), Gaps = 30/289 (10%)
Query: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
+GD++ + K+ + N+LE GE GR+ + + L +P P Q ++ G
Sbjct: 61 KGDIVYIHKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQV-LEYG- 115
Query: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN--QIGIFPANYVKVIIDI 496
AV + F + +L+ GE + L+ K++ +WY G + GIFPA+YV+V
Sbjct: 116 -EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV---- 170
Query: 497 PEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 556
RE C G + + S L+ + G+
Sbjct: 171 ------SREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRSPADPIDLGGQTSP 222
Query: 557 RTGIFPLNFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWC--EALH 611
R F EP ++ T G + ++ P + D G++S N+ W A++
Sbjct: 223 RRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-NTSQIHWTPYRAMY 279
Query: 612 SFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 658
+ + D+L + GDR+ ++++ D W G R + G FP +V P
Sbjct: 280 QYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 328
Score = 52.4 bits (124), Expect = 1e-06
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 672 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 39 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 95
Score = 32.7 bits (73), Expect = 1.2
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 99.0 bits (245), Expect = 1e-20
Identities = 68/251 (27%), Positives = 115/251 (45%), Gaps = 40/251 (15%)
Query: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 654 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 711
Query: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 712 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 771
Query: 564 NFVEPVE-----------DYPTSGANVLSTKV------------PLKTKKEDSGSNSQV- 599
+V+ ++ D P S + S P T+ E S Q
Sbjct: 772 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQ 831
Query: 600 ----------NSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDR 647
S +AL+S+ + D+L + GD + ++E+ D W G R +
Sbjct: 832 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 891
Query: 648 EGIFPAVFVRP 658
G FP +V+P
Sbjct: 892 FGTFPGNYVKP 902
Score = 77.8 bits (190), Expect = 3e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 588 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 647
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 637 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 689
Query: 648 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 702
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 690 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 749
Query: 703 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 729
VD++W G + G S GIFP Y+ ++
Sbjct: 750 QVDENWYEGRIPGTSRQGIFPITYVDVIK 778
Score = 73.6 bits (179), Expect = 6e-13
Identities = 62/271 (22%), Positives = 108/271 (39%), Gaps = 75/271 (27%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 651 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 702
Query: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 703 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 754
Query: 639 WCRGRL--QDREGIFPAVFV----RPC------------------PAEAKSMLA------ 668
W GR+ R+GIFP +V RP A A L+
Sbjct: 755 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRA 814
Query: 669 -----------IVPKGRKAKALYDFRGENED----------------ELSFKAGDIITEL 701
+ P+ ++ + D ++D EL + GDI+ +
Sbjct: 815 GPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 874
Query: 702 ESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 730
E DD W G + G FP NY++ L +
Sbjct: 875 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 905
Score = 59.3 bits (142), Expect = 1e-08
Identities = 57/243 (23%), Positives = 101/243 (41%), Gaps = 58/243 (23%)
Query: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 667 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 721
Query: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 493
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 722 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
Query: 494 --------IDIPEGGNGKRECVSS-----HCVKGSRCV---------------------- 518
+D+P + R +S H ++ +
Sbjct: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
Query: 519 ----------ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFV 566
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V
Sbjct: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
Query: 567 EPV 569
+P+
Sbjct: 901 KPL 903
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 96.3 bits (238), Expect = 9e-20
Identities = 83/311 (26%), Positives = 144/311 (46%), Gaps = 30/311 (9%)
Query: 380 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAP 439
GD++ +L + +L +K + TG+ S ++I+T PS + G
Sbjct: 26 GDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI-----------PS-----LKEGER 69
Query: 440 HAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQIGIFPANYVKVIIDIPE 498
V + +F ++++D+L L G++V L W +G +C G FP++ V+ + +
Sbjct: 70 LFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQ 129
Query: 499 GGNGKRECVSSHCVKGSRCVAR--FEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 556
+ + S AR + +EL F EG++I + W GE+ G
Sbjct: 130 SRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG 189
Query: 557 RTGIFPLNFVE------PVEDYPTSGAN---VLSTKVPLKTKKEDSGSNSQVNSLPAEWC 607
R GIFP FVE V++ +SG +++ +V +E+ G + P +
Sbjct: 190 RRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEE-PGTYG 248
Query: 608 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCP-AEAKSM 666
AL+ F A ++L F+ GD+I+IL L+ W G L+ R GIFP FV+ CP +
Sbjct: 249 VALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEET 308
Query: 667 LAIVPKGRKAK 677
+A+ +G A+
Sbjct: 309 MALPQEGSLAR 319
Score = 94.7 bits (234), Expect = 3e-19
Identities = 82/316 (25%), Positives = 134/316 (42%), Gaps = 60/316 (18%)
Query: 444 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGK 503
+ DF ++L L G+I+ +L +D W G + G FP+++V+ I+ IP G+
Sbjct: 10 IFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVE-IVTIPSLKEGE 68
Query: 504 RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARG-EVRGRTGIFP 562
R V C+ E+ ++ D L G+++IL W +G G G FP
Sbjct: 69 RLFV---------CIC--EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFP 117
Query: 563 LNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP---AEWCEALHSFTAETSD 619
+ V ++ L ++ S S + +P AL +A+ +
Sbjct: 118 SSCVR---------------ELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDE 162
Query: 620 DLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR---PCPAEAKSMLA-------- 668
+L F+ GD I I+ + W G L+ R GIFP FV P +S+ +
Sbjct: 163 ELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIV 222
Query: 669 ------------IVP------KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMS 710
I P G ALY F+ +EL F+ GD I L +++D W+
Sbjct: 223 NGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLE 282
Query: 711 GELMGKSGIFPKNYIQ 726
G L G++GIFP +++
Sbjct: 283 GSLKGRTGIFPYRFVK 298
Score = 73.2 bits (178), Expect = 8e-13
Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 36/225 (16%)
Query: 514 GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 573
GS A F++ +EL G+II + V+E W G+ TG FP +FVE V
Sbjct: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT--- 60
Query: 574 TSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILE 633
+P S + L CE FT++ D+L RGD + +
Sbjct: 61 ----------IP---------SLKEGERLFVCICE----FTSQELDNLPLHRGDLVILDG 97
Query: 634 RLDSDWCRGR-LQDREGIFPAVFVRP-CPAE------AKSMLAIVPKGR--KAKALYDFR 683
+ W +GR G FP+ VR C + ++S L +P+ +A+AL
Sbjct: 98 IPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLS 157
Query: 684 GENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
+ ++EL F+ GD+IT + + W GEL G+ GIFP+ +++ L
Sbjct: 158 AQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELL 202
Score = 40.4 bits (93), Expect = 0.006
Identities = 19/58 (32%), Positives = 32/58 (55%)
Query: 673 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQI 730
G +A++DF +EL GDII L VD+ W+ G+ +G FP ++++ + I
Sbjct: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI 61
Score = 38.1 bits (87), Expect = 0.029
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Query: 661 AEAKSMLAIVPKGRKAK------ALYDFRGENEDELSFKAGDIITELESVD----DDWMS 710
A+A + P G +A+ A+Y F+ N +ELS A + LE D +W
Sbjct: 1497 AQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWL 1556
Query: 711 GELMGKSGIFPKNYIQ 726
E+ GK G P NYI+
Sbjct: 1557 AEVNGKKGYVPSNYIR 1572
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 90.5 bits (223), Expect = 5e-18
Identities = 90/329 (27%), Positives = 139/329 (42%), Gaps = 55/329 (16%)
Query: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTD-WYRGNCRNQIGIFPANYVKVI------- 493
+V +D+ A D+L + GEI+ ++K+ + W G + G+FP N+VK I
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFK 64
Query: 494 -----------------------IDIPEGGNGKRECVSS--HCVKGSRCVARFEYIGEQK 528
+P GG + K +C FEYI + +
Sbjct: 65 DDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNE 124
Query: 529 DELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE---DYPTSGANVLSTKVP 585
DEL G+II + E V E W G + + G+FP NFV+ +E D T A S V
Sbjct: 125 DELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVL 184
Query: 586 LKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS------DDLSFKRGDRIQILERLDSDW 639
+G S + SL A S T D+ FK G +++ R S
Sbjct: 185 -------AGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDI-FKEGS-VKLRTRTSSSE 235
Query: 640 CRGRLQDREGIFPAVFVRPCPAE-AKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDI 697
+ ++ I ++ + E K+ K ++ + L+ + G NEDEL+FK G+I
Sbjct: 236 TEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEI 295
Query: 698 I--TELESVDDDWMSGELMGKSGIFPKNY 724
I E+ + W GEL GK G+FP N+
Sbjct: 296 IHLISKETGEAGWWRGELNGKEGVFPDNF 324
Score = 68.2 bits (165), Expect = 3e-11
Identities = 43/161 (26%), Positives = 72/161 (44%), Gaps = 40/161 (24%)
Query: 611 HSFTAETSDDLSFKRGDRIQILERLDSD-WCRGRLQDREGIFPAVFVRPCPAEAKSMLAI 669
+ + A D+L+ + G+ I+ +++L + W G L R G+FP FV+ E +
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Query: 670 VP---------------------------------------KGRKAKALYDFRGENEDEL 690
+P K R+ K L+++ +NEDEL
Sbjct: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
Query: 691 SFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 731
K GDII E V++ W SG L K G+FP N+++ L+++
Sbjct: 128 ELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVT 168
Score = 50.8 bits (120), Expect = 4e-06
Identities = 26/57 (45%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Query: 517 CVARFEYIGEQKDELSFSEGEII--ILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 571
C F Y G +DEL+F EGEII I KE W RGE+ G+ G+FP NF + +
Sbjct: 274 CRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINE 330
Score = 34.7 bits (78), Expect = 0.32
Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Query: 453 DDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDI 496
D+L GEI++L+ K + W+RG + G+FP N+ I ++
Sbjct: 286 DELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINEL 331
Score = 30.4 bits (67), Expect = 6.1
Identities = 26/85 (30%), Positives = 30/85 (35%), Gaps = 13/85 (15%)
Query: 100 KPELPKK---PNPGLIR------SVNPEIPGRGPLAESSDSGKKVPTPAPR----PLLLK 146
KP P K P P LI S+ PE E S P P+ P
Sbjct: 340 KPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKAS 399
Query: 147 KSVSSENPTYPSAPLKPVTVPPRLA 171
+ S YP P KPV PP +A
Sbjct: 400 NLLRSSGTVYPKRPEKPVPPPPPIA 424
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 88.2 bits (217), Expect = 2e-17
Identities = 83/341 (24%), Positives = 132/341 (38%), Gaps = 71/341 (20%)
Query: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 498
P+ L+ + ++ DL G+I+ L K+D WY G G PA+Y++ I +P
Sbjct: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP- 255
Query: 499 GGNGKRECVSSHCVKGSRCVARFEY--IGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 556
H + + FE + KD L+F++ EI+ + V+E WA G +
Sbjct: 256 -----------HAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGD 304
Query: 557 RTGIFPLNFVEPVE--------DYP-TSGANVLSTKVPLKTKKEDSGSNSQVNSLPA--- 604
+ GIFPL +VE + D P + A+ + +P DSG+ + V P
Sbjct: 305 KIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP-----SDSGAVASVAPSPTLSS 359
Query: 605 --------------EWCEALHSFTA-----ETSDDLSFKRGDRIQ--ILERLDSDWCRGR 643
+ + HSFTA +S S + I +L R
Sbjct: 360 SGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAAR 419
Query: 644 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAK-----------------ALYDFRGEN 686
+ D + A + + A S VP+ ALY ++ +
Sbjct: 420 IGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQK 479
Query: 687 EDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYI 725
DEL G++ LE D W G + G SG+FP NY+
Sbjct: 480 SDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
Score = 73.2 bits (178), Expect = 8e-13
Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 17/126 (13%)
Query: 608 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF---VRPCPAEAK 664
+AL+S+ + DL F +GD I + ++D W G L +G PA + ++P P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAP- 258
Query: 665 SMLAIVPKGRKAKALYDFRGENEDE----LSFKAGDIITELESVDDDWMSGELMGKSGIF 720
P+G KALYDF +++D+ L+F +I+T L VD++W G L K GIF
Sbjct: 259 ------PQG---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIF 309
Query: 721 PKNYIQ 726
P Y++
Sbjct: 310 PLLYVE 315
Score = 57.0 bits (136), Expect = 6e-08
Identities = 92/436 (21%), Positives = 154/436 (35%), Gaps = 86/436 (19%)
Query: 281 VRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSA----TRRSNKKLPFNRSSSDMD 336
VR+ + RP G T P PP + P + P L+ S P S++
Sbjct: 115 VRLLDGIRQRPRAG-TSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGS 173
Query: 337 LQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYS---------KYMRGDVLVMLK 387
LAT + ++ +P L P G LYS K+ +GD++V+ +
Sbjct: 174 TAGSLRELATSRTAPAAK-----NPCLLPY---GKALYSYEGKEPGDLKFNKGDIIVLRR 225
Query: 388 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDF 447
+ + + + G + S ++ I PL P+ P P L+DF
Sbjct: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPL-------PHAP-----------PQGKALYDF 267
Query: 448 PAEQVDD----LNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV------KVIID-- 495
+ D L T EI+ +L ++D +W G ++IGIFP YV K +I+
Sbjct: 268 EMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMD 327
Query: 496 -------------IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILK 542
+P S + S V+ F+ + K +
Sbjct: 328 KPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSV 387
Query: 543 EYVNEEWARGE-----------------VRGRTG-IFPLNFVEPVEDYPTSGANVLSTKV 584
+ + + A R G + L+ P +D +S A T V
Sbjct: 388 THRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDV-SSSAGSTPTAV 446
Query: 585 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGR- 643
P LP AL+++ + SD+L +G+ ++LE+ W +G
Sbjct: 447 PRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGAS 506
Query: 644 -LQDREGIFPAVFVRP 658
G+FP +V P
Sbjct: 507 LRTGVSGVFPGNYVTP 522
Score = 53.9 bits (128), Expect = 5e-07
Identities = 28/69 (40%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 661 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 720
A A ++P G KALY + G+ +L F GDII VD+ W GEL G G
Sbjct: 187 APAAKNPCLLPYG---KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFL 243
Query: 721 PKNYIQFLQ 729
P +YIQ +Q
Sbjct: 244 PASYIQCIQ 252
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/63 (34%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQI-GIFPANYVKVIIDIPEG 499
+ L+ + ++ D+L L GE+ +LEK W++G + R + G+FP NYV + +P G
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
Query: 500 GNG 502
G G
Sbjct: 530 GAG 532
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 518 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 575
+A + Y ++ DEL +GE+ + E + W +G G +G+FP N+V PV P
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
Query: 576 GA 577
GA
Sbjct: 530 GA 531
Score = 38.9 bits (89), Expect = 0.017
Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 644 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGR-----KAKALYDFRGENEDELSFKAGDII 698
L + G F P SM AI P+ + + + + + ++E E+ K GDI+
Sbjct: 791 LHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIV 850
Query: 699 TELESVDDDWMSGELM--GKSGIFPKNYIQ 726
+ +D W G L G++G+FP ++++
Sbjct: 851 FVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 37.0 bits (84), Expect = 0.065
Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 18/102 (17%)
Query: 557 RTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE 616
+ G LNF P P S A + + LP E + S+ +
Sbjct: 794 KAGSLDLNFTSPSRQAPLSMAAI----------------RPEPKLLPRERYRVVVSYPPQ 837
Query: 617 TSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFV 656
+ ++ K GD + + ++ + W +G LQ R G+FP FV
Sbjct: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879
Score = 35.4 bits (80), Expect = 0.19
Identities = 16/47 (34%), Positives = 29/47 (61%), Gaps = 2/47 (4%)
Query: 523 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 567
Y + + E+ EG+I+ + + + W +G ++ GRTG+FP +FVE
Sbjct: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 35.0 bits (79), Expect = 0.25
Identities = 14/51 (27%), Positives = 31/51 (60%), Gaps = 2/51 (3%)
Query: 443 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 491
V+ +P + ++ L G+IV++ +K + WY+G + + G+FP ++V+
Sbjct: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 84.7 bits (208), Expect = 3e-16
Identities = 48/162 (29%), Positives = 84/162 (51%), Gaps = 15/162 (9%)
Query: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 825 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 882
Query: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 883 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 942
Query: 564 NFVEPVE-----------DYPTSGANVLSTKVPLKTKKEDSG 594
+V+ ++ D P S + S + +E+SG
Sbjct: 943 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
Score = 77.8 bits (190), Expect = 3e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 588 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 647
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 808 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 860
Query: 648 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 702
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 861 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 920
Query: 703 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 729
VD++W G + G S GIFP Y+ ++
Sbjct: 921 QVDENWYEGRIPGTSRQGIFPITYVDVIK 949
Score = 69.7 bits (169), Expect = 9e-12
Identities = 38/140 (27%), Positives = 69/140 (49%), Gaps = 18/140 (12%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 873
Query: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 874 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 925
Query: 639 WCRGRL--QDREGIFPAVFV 656
W GR+ R+GIFP +V
Sbjct: 926 WYEGRIPGTSRQGIFPITYV 945
Score = 53.9 bits (128), Expect = 5e-07
Identities = 52/209 (24%), Positives = 84/209 (40%), Gaps = 17/209 (8%)
Query: 287 LPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATR--RSNKKLPFNRSSSDMDLQKKQSNL 344
L PV+ +P P++ P P + + + R ++ R + KK
Sbjct: 952 LVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLK 1011
Query: 345 ATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGR 404
+ + + S + D P +PG PL S + + +QTE + + GE GR
Sbjct: 1012 PSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEA----EQTERH----RGGEQAGR 1063
Query: 405 VHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVY 464
+ P + R P+ +Q A L+ + + D+L L G+IV
Sbjct: 1064 KAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQA-----LYSYIPQNDDELELRDGDIVD 1118
Query: 465 LLEKIDTDWYRGNCR--NQIGIFPANYVK 491
++EK D W+ G R Q G FP NYVK
Sbjct: 1119 VMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 8/117 (6%)
Query: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 838 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 892
Query: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI 493
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 893 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 948
Score = 43.9 bits (102), Expect = 5e-04
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 677 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 730
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 1096 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
Score = 35.4 bits (80), Expect = 0.19
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 1097 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 84.0 bits (206), Expect = 5e-16
Identities = 41/127 (32%), Positives = 73/127 (57%), Gaps = 4/127 (3%)
Query: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 803 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 860
Query: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 861 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 920
Query: 564 NFVEPVE 570
+V+ ++
Sbjct: 921 TYVDVIK 927
Score = 77.8 bits (190), Expect = 3e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 588 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 647
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 786 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 838
Query: 648 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 702
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 839 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 898
Query: 703 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 729
VD++W G + G S GIFP Y+ ++
Sbjct: 899 QVDENWYEGRIPGTSRQGIFPITYVDVIK 927
Score = 70.1 bits (170), Expect = 7e-12
Identities = 50/207 (24%), Positives = 90/207 (43%), Gaps = 31/207 (14%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 851
Query: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 852 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 903
Query: 639 WCRGRL--QDREGIFPAVFV----RPC---PAEAKSMLAIVPKGRKAKALYDFRGENE-- 687
W GR+ R+GIFP +V RP P + + R A A F ++
Sbjct: 904 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLI 963
Query: 688 ----DELSFKAGDIITELESVDDDWMS 710
L + E+ +V +W+S
Sbjct: 964 TPAPSSLPHSRRALSPEMHAVTSEWIS 990
Score = 49.7 bits (117), Expect = 1e-05
Identities = 39/130 (30%), Positives = 57/130 (43%), Gaps = 15/130 (11%)
Query: 364 PPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSR 423
P +PG PL S + + +QTE + + GE GR + P + R
Sbjct: 1172 PEESRPGKPLGSAFPGSEA----EQTERH----RGGEQAGRKAARRGGSQQPQAQQRRVT 1223
Query: 424 PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQ 481
P+ +Q A L+ + + D+L L G+IV ++EK D W+ G R Q
Sbjct: 1224 PDRSQTSQDLFSYQA-----LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 1278
Query: 482 IGIFPANYVK 491
G FP NYVK
Sbjct: 1279 FGTFPGNYVK 1288
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 8/117 (6%)
Query: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 816 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 870
Query: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI 493
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 871 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 926
Score = 43.9 bits (102), Expect = 5e-04
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 677 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 730
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1292
Score = 35.4 bits (80), Expect = 0.19
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,162,341
Number of Sequences: 37866
Number of extensions: 2124652
Number of successful extensions: 16069
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 277
Number of HSP's successfully gapped in prelim test: 844
Number of HSP's that attempted gapping in prelim test: 9868
Number of HSP's gapped (non-prelim): 5022
length of query: 731
length of database: 18,247,518
effective HSP length: 110
effective length of query: 621
effective length of database: 14,082,258
effective search space: 8745082218
effective search space used: 8745082218
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.