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Search of human proteins with 193083143
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
(767 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 1560 0.0
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 1546 0.0
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 1465 0.0
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 125 1e-28
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 125 1e-28
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 125 1e-28
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 115 1e-25
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 115 1e-25
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 114 4e-25
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 114 4e-25
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 112 1e-24
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 107 3e-23
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 106 9e-23
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 106 9e-23
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 105 1e-22
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 105 2e-22
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 105 2e-22
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 103 5e-22
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 101 2e-21
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 101 2e-21
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 101 2e-21
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 101 2e-21
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 100 9e-21
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 100 9e-21
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 99 1e-20
gi|39930351 dynamin binding protein [Homo sapiens] 96 1e-19
gi|11321634 CD2-associated protein [Homo sapiens] 91 5e-18
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 88 3e-17
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 85 3e-16
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 84 5e-16
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 1560 bits (4038), Expect = 0.0
Identities = 767/767 (100%), Positives = 767/767 (100%)
Query: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA
Sbjct: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
Query: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP
Sbjct: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
Query: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK
Sbjct: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
Query: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT
Sbjct: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
Query: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE
Sbjct: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
Query: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK
Sbjct: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
Query: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV 420
KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV
Sbjct: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV 420
Query: 421 MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVL 480
MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVL
Sbjct: 421 MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVL 480
Query: 481 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKR 540
HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKR
Sbjct: 481 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKR 540
Query: 541 ECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLN 600
ECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLN
Sbjct: 541 ECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLN 600
Query: 601 FVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFK 660
FVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFK
Sbjct: 601 FVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFK 660
Query: 661 RGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRG 720
RGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRG
Sbjct: 661 RGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRG 720
Query: 721 ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 767
ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS
Sbjct: 721 ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 767
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 1546 bits (4004), Expect = 0.0
Identities = 767/790 (97%), Positives = 767/790 (97%), Gaps = 23/790 (2%)
Query: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA
Sbjct: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
Query: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP
Sbjct: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
Query: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK
Sbjct: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
Query: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT
Sbjct: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
Query: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE
Sbjct: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
Query: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK
Sbjct: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
Query: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYM------ 414
KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYM
Sbjct: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHG 420
Query: 415 -----------------RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 457
RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR
Sbjct: 421 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 480
Query: 458 SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ 517
SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ
Sbjct: 481 SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ 540
Query: 518 IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL 577
IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL
Sbjct: 541 IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL 600
Query: 578 KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS 637
KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS
Sbjct: 601 KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS 660
Query: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
Query: 698 EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP 757
EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP
Sbjct: 721 EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP 780
Query: 758 KNYIQFLQIS 767
KNYIQFLQIS
Sbjct: 781 KNYIQFLQIS 790
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 1465 bits (3792), Expect = 0.0
Identities = 730/767 (95%), Positives = 730/767 (95%), Gaps = 36/767 (4%)
Query: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA
Sbjct: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
Query: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP
Sbjct: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
Query: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK
Sbjct: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
Query: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVL
Sbjct: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLG-------- 232
Query: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
LHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE
Sbjct: 233 ----------------------------LHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 264
Query: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK
Sbjct: 265 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 324
Query: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV 420
KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV
Sbjct: 325 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV 384
Query: 421 MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVL 480
MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVL
Sbjct: 385 MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVL 444
Query: 481 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKR 540
HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKR
Sbjct: 445 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKR 504
Query: 541 ECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLN 600
ECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLN
Sbjct: 505 ECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLN 564
Query: 601 FVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFK 660
FVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFK
Sbjct: 565 FVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFK 624
Query: 661 RGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRG 720
RGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRG
Sbjct: 625 RGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRG 684
Query: 721 ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 767
ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS
Sbjct: 685 ENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 731
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 125 bits (314), Expect = 1e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 463 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 522
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 863 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 920
Query: 523 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 570
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 921 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 976
Query: 571 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 630
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 977 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1018
Query: 631 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 685
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 1019 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1078
Query: 686 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 744
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 1079 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1137
Query: 745 MSGELMGKSGIFPKNYIQ 762
GE+ G +G+FP NY++
Sbjct: 1138 WQGEINGVTGLFPSNYVK 1155
Score = 92.8 bits (229), Expect = 1e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 789 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 848
Query: 389 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 427
F V P P H + + + D++ +L+Q EN
Sbjct: 849 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 906
Query: 428 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 482
+ G G S +KII P E R P A + A ++V L+
Sbjct: 907 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 964
Query: 483 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 542
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 965 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1022
Query: 543 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 597
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 1023 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1080
Query: 598 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 654
P + V+ P + T + + + A++ + A
Sbjct: 1081 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1116
Query: 655 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 693
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 1117 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
Score = 78.6 bits (192), Expect = 2e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 459 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 513
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 1008 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1067
Query: 514 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 568
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 1068 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1120
Query: 569 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 623
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 1121 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1180
Query: 624 TKKE 627
K++
Sbjct: 1181 RKRQ 1184
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 480 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 537
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 738 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 794
Query: 538 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 593
K ++ + V S E + + + VN W + R
Sbjct: 795 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 854
Query: 594 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 653
T + P V P+ G V +L A +AL S+TA+
Sbjct: 855 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 886
Query: 654 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 707
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 887 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 945
Query: 708 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 758
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 946 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1004
Query: 759 NYIQ 762
NY++
Sbjct: 1005 NYVK 1008
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 612
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796
Query: 613 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 672
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 797 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 843
Query: 673 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 732
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 844 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 896
Query: 733 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 897 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 927
Score = 53.9 bits (128), Expect = 5e-07
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 416 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 470
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 1050 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1102
Query: 471 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 530
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 1103 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1158
Query: 531 D 531
D
Sbjct: 1159 D 1159
Score = 46.6 bits (109), Expect = 9e-05
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 713 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 762
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 575 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 633
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 714
Query: 634 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 680
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 715 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 774
Query: 681 QDREGIFPAVFVRPCPAEAKSMLAIVPK 708
Q G FP +V P+ +++ A+ PK
Sbjct: 775 QGNFGWFPCNYVEKMPS-SENEKAVSPK 801
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 125 bits (314), Expect = 1e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 463 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 522
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
Query: 523 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 570
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
Query: 571 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 630
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
Query: 631 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 685
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
Query: 686 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 744
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
Query: 745 MSGELMGKSGIFPKNYIQ 762
GE+ G +G+FP NY++
Sbjct: 1165 WQGEINGVTGLFPSNYVK 1182
Score = 92.8 bits (229), Expect = 1e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
Query: 389 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 427
F V P P H + + + D++ +L+Q EN
Sbjct: 876 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 933
Query: 428 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 482
+ G G S +KII P E R P A + A ++V L+
Sbjct: 934 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 991
Query: 483 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 542
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 992 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1049
Query: 543 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 597
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 1050 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1107
Query: 598 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 654
P + V+ P + T + + + A++ + A
Sbjct: 1108 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1143
Query: 655 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 693
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 1144 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
Score = 78.6 bits (192), Expect = 2e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 459 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 513
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 1035 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1094
Query: 514 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 568
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 1095 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1147
Query: 569 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 623
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 1148 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1207
Query: 624 TKKE 627
K++
Sbjct: 1208 RKRQ 1211
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 480 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 537
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
Query: 538 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 593
K ++ + V S E + + + VN W + R
Sbjct: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
Query: 594 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 653
T + P V P+ G V +L A +AL S+TA+
Sbjct: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
Query: 654 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 707
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
Query: 708 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 758
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
Query: 759 NYIQ 762
NY++
Sbjct: 1032 NYVK 1035
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 612
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
Query: 613 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 672
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
Query: 673 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 732
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
Query: 733 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
Score = 53.9 bits (128), Expect = 5e-07
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 416 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 470
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1129
Query: 471 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 530
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 1130 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1185
Query: 531 D 531
D
Sbjct: 1186 D 1186
Score = 46.6 bits (109), Expect = 9e-05
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 713 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 762
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 575 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 633
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
Query: 634 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 680
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
Query: 681 QDREGIFPAVFVRPCPAEAKSMLAIVPK 708
Q G FP +V P+ +++ A+ PK
Sbjct: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 125 bits (314), Expect = 1e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 463 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 522
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
Query: 523 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 570
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
Query: 571 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 630
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
Query: 631 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 685
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
Query: 686 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 744
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
Query: 745 MSGELMGKSGIFPKNYIQ 762
GE+ G +G+FP NY++
Sbjct: 1165 WQGEINGVTGLFPSNYVK 1182
Score = 92.8 bits (229), Expect = 1e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
Query: 389 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 427
F V P P H + + + D++ +L+Q EN
Sbjct: 876 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 933
Query: 428 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 482
+ G G S +KII P E R P A + A ++V L+
Sbjct: 934 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 991
Query: 483 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 542
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 992 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1049
Query: 543 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 597
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 1050 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1107
Query: 598 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 654
P + V+ P + T + + + A++ + A
Sbjct: 1108 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1143
Query: 655 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 693
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 1144 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
Score = 78.6 bits (192), Expect = 2e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 459 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 513
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 1035 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1094
Query: 514 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 568
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 1095 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1147
Query: 569 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 623
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 1148 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1207
Query: 624 TKKE 627
K++
Sbjct: 1208 RKRQ 1211
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 480 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 537
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
Query: 538 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 593
K ++ + V S E + + + VN W + R
Sbjct: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
Query: 594 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 653
T + P V P+ G V +L A +AL S+TA+
Sbjct: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
Query: 654 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 707
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
Query: 708 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 758
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
Query: 759 NYIQ 762
NY++
Sbjct: 1032 NYVK 1035
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 612
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
Query: 613 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 672
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
Query: 673 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 732
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
Query: 733 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
Score = 53.9 bits (128), Expect = 5e-07
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 416 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 470
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1129
Query: 471 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 530
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 1130 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1185
Query: 531 D 531
D
Sbjct: 1186 D 1186
Score = 46.6 bits (109), Expect = 9e-05
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 713 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 762
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 575 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 633
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
Query: 634 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 680
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
Query: 681 QDREGIFPAVFVRPCPAEAKSMLAIVPK 708
Q G FP +V P+ +++ A+ PK
Sbjct: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 115 bits (289), Expect = 1e-25
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 45/312 (14%)
Query: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII------ 530
A L+ + A++ + LN +++ +LE+ D W+ G + Q G FP +YVK+I
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 531 --------DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 582
+ P + V G +A + Y ++ +L+F +G++I++ + +
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-D 1035
Query: 583 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 642
+W G V + G+FP N+V ++D SG +G + P E
Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVR-LKDSEGSGT---------------AGKTGSLGKKP-EI 1078
Query: 643 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE-----GIFPAVFVRPC-P 696
+ + S+TA + L+ G I I ++ W G LQ R G FPA +V+ P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 697 AEAKSMLAIVPKGRKAKA------LYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 750
+K PK A +YD+ +N+DEL+F G II L D DW GE+
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 751 GKSGIFPKNYIQ 762
G+ G+FP NY++
Sbjct: 1199 GQVGLFPSNYVK 1210
Score = 83.6 bits (205), Expect = 6e-16
Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILK-EYVNEE------WARGEVRGRTGIFPLNFVE--PV 605
A + + DE++ G+I+++K E+V+E W GE++G+TG FP N+ E P
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPE 806
Query: 606 EDYP------TSGANVLSTKVPLK-TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLS 658
+ P T + + K+ L+ T + ++S+ ++ P W + ++ T++
Sbjct: 807 NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPE 866
Query: 659 FKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDF 718
D L G+L+ R PA P+ V +G +A+ALY +
Sbjct: 867 TDNWDAWAAQPSLTVP-SAGQLRQRSAFTPATATGSSPSPVLGQGEKV-EGLQAQALYPW 924
Query: 719 RGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
R + ++ L+F D+IT LE D W GE+ G+ G FPK+Y++ +
Sbjct: 925 RAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI 969
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 548 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 607
V+G + A + + ++ + L+F++ ++I + E + W GEV+G+ G FP ++V+ +
Sbjct: 913 VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISG 971
Query: 608 --YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRI 665
++ + S++ P K+ S + V S E A++++ + DL+F++GD I
Sbjct: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVS--GEEFIAMYTYESSEQGDLTFQQGDVI 1029
Query: 666 QILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML----AIVPKGRKAKALYDFRGE 721
+ ++ D DW G + D+ G+FP+ +VR +E ++ K A+ + +
Sbjct: 1030 LVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTAT 1088
Query: 722 NEDELSFKAGDIITELESVDDDWMSGELMGKS-----GIFPKNYIQFL 764
++L+ G +I + W GEL + G FP NY++ L
Sbjct: 1089 GPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 72.0 bits (175), Expect = 2e-12
Identities = 40/140 (28%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
Query: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIID 531
A V+ + A + L L G+++ + +K W+ G + QIG FPANYVK++
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 532 IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR 591
S+ + + ++Y + DEL+F++G+II + + +W +GEV
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 592 GRTGIFPLNFVEPVEDYPTS 611
G+ G+FP N+V+ D S
Sbjct: 1199 GQVGLFPSNYVKLTTDMDPS 1218
Score = 64.3 bits (155), Expect = 4e-10
Identities = 73/318 (22%), Positives = 126/318 (39%), Gaps = 53/318 (16%)
Query: 481 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNG 538
HD Q D+ + GE V + + W G + + G FPANY + I ++P
Sbjct: 756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKP 815
Query: 539 KRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWA--------RGEV 590
+ S+ K + + E L+ + E WA
Sbjct: 816 VTDSTSAPAPKLA--------LRETPAPLAVTSSE----PSTTPNNWADFSSTWPTSTNE 863
Query: 591 RGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGS-----NSQVNSLPAEWCEA 645
+ T + +P P++G + T S S +V L A+ A
Sbjct: 864 KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQ---A 920
Query: 646 LHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR------------ 693
L+ + A+ + L+F + D I +LE+ D W G +Q ++G FP +V+
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKSTSM 979
Query: 694 -----PCPAEAKSMLAIVPK----GRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 744
PA K + + K G + A+Y + + +L+F+ GD+I + D DW
Sbjct: 980 DSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVIL-VTKKDGDW 1038
Query: 745 MSGELMGKSGIFPKNYIQ 762
+G + K+G+FP NY++
Sbjct: 1039 WTGTVGDKAGVFPSNYVR 1056
Score = 46.6 bits (109), Expect = 9e-05
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 678 GRL--QDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA---KALYDFRGENEDELSFKAGD 732
GRL Q +E PAV AE + + K +ALY F + DE++ + GD
Sbjct: 706 GRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGD 765
Query: 733 IIT-------ELESVDDDWMSGELMGKSGIFPKNYIQ 762
I+ E ++ + W+ GEL GK+G FP NY +
Sbjct: 766 IVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 115 bits (289), Expect = 1e-25
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 45/312 (14%)
Query: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII------ 530
A L+ + A++ + LN +++ +LE+ D W+ G + Q G FP +YVK+I
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 531 --------DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 582
+ P + V G +A + Y ++ +L+F +G++I++ + +
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-D 1035
Query: 583 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 642
+W G V + G+FP N+V ++D SG +G + P E
Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVR-LKDSEGSGT---------------AGKTGSLGKKP-EI 1078
Query: 643 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE-----GIFPAVFVRPC-P 696
+ + S+TA + L+ G I I ++ W G LQ R G FPA +V+ P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 697 AEAKSMLAIVPKGRKAKA------LYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 750
+K PK A +YD+ +N+DEL+F G II L D DW GE+
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 751 GKSGIFPKNYIQ 762
G+ G+FP NY++
Sbjct: 1199 GQVGLFPSNYVK 1210
Score = 83.6 bits (205), Expect = 6e-16
Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILK-EYVNEE------WARGEVRGRTGIFPLNFVE--PV 605
A + + DE++ G+I+++K E+V+E W GE++G+TG FP N+ E P
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPE 806
Query: 606 EDYP------TSGANVLSTKVPLK-TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLS 658
+ P T + + K+ L+ T + ++S+ ++ P W + ++ T++
Sbjct: 807 NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPE 866
Query: 659 FKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDF 718
D L G+L+ R PA P+ V +G +A+ALY +
Sbjct: 867 TDNWDAWAAQPSLTVP-SAGQLRQRSAFTPATATGSSPSPVLGQGEKV-EGLQAQALYPW 924
Query: 719 RGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
R + ++ L+F D+IT LE D W GE+ G+ G FPK+Y++ +
Sbjct: 925 RAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI 969
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 548 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 607
V+G + A + + ++ + L+F++ ++I + E + W GEV+G+ G FP ++V+ +
Sbjct: 913 VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISG 971
Query: 608 --YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRI 665
++ + S++ P K+ S + V S E A++++ + DL+F++GD I
Sbjct: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVS--GEEFIAMYTYESSEQGDLTFQQGDVI 1029
Query: 666 QILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML----AIVPKGRKAKALYDFRGE 721
+ ++ D DW G + D+ G+FP+ +VR +E ++ K A+ + +
Sbjct: 1030 LVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTAT 1088
Query: 722 NEDELSFKAGDIITELESVDDDWMSGELMGKS-----GIFPKNYIQFL 764
++L+ G +I + W GEL + G FP NY++ L
Sbjct: 1089 GPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 72.0 bits (175), Expect = 2e-12
Identities = 40/140 (28%), Positives = 70/140 (50%), Gaps = 5/140 (3%)
Query: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIID 531
A V+ + A + L L G+++ + +K W+ G + QIG FPANYVK++
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 532 IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR 591
S+ + + ++Y + DEL+F++G+II + + +W +GEV
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 592 GRTGIFPLNFVEPVEDYPTS 611
G+ G+FP N+V+ D S
Sbjct: 1199 GQVGLFPSNYVKLTTDMDPS 1218
Score = 64.3 bits (155), Expect = 4e-10
Identities = 73/318 (22%), Positives = 126/318 (39%), Gaps = 53/318 (16%)
Query: 481 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNG 538
HD Q D+ + GE V + + W G + + G FPANY + I ++P
Sbjct: 756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKP 815
Query: 539 KRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWA--------RGEV 590
+ S+ K + + E L+ + E WA
Sbjct: 816 VTDSTSAPAPKLA--------LRETPAPLAVTSSE----PSTTPNNWADFSSTWPTSTNE 863
Query: 591 RGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGS-----NSQVNSLPAEWCEA 645
+ T + +P P++G + T S S +V L A+ A
Sbjct: 864 KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQ---A 920
Query: 646 LHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR------------ 693
L+ + A+ + L+F + D I +LE+ D W G +Q ++G FP +V+
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKSTSM 979
Query: 694 -----PCPAEAKSMLAIVPK----GRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 744
PA K + + K G + A+Y + + +L+F+ GD+I + D DW
Sbjct: 980 DSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVIL-VTKKDGDW 1038
Query: 745 MSGELMGKSGIFPKNYIQ 762
+G + K+G+FP NY++
Sbjct: 1039 WTGTVGDKAGVFPSNYVR 1056
Score = 46.6 bits (109), Expect = 9e-05
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 678 GRL--QDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA---KALYDFRGENEDELSFKAGD 732
GRL Q +E PAV AE + + K +ALY F + DE++ + GD
Sbjct: 706 GRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGD 765
Query: 733 IIT-------ELESVDDDWMSGELMGKSGIFPKNYIQ 762
I+ E ++ + W+ GEL GK+G FP NY +
Sbjct: 766 IVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 114 bits (284), Expect = 4e-25
Identities = 116/456 (25%), Positives = 192/456 (42%), Gaps = 54/456 (11%)
Query: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
+PGK + PPPLP T + + L S+ G+ G PPR
Sbjct: 395 EPGKSSILQHERPPPLP----------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR- 443
Query: 324 PPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQS 378
+G P+ + P + P RPP L + + + FN +SS D L++ S
Sbjct: 444 -----SGAPTPSSRAPA-LSPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMS 496
Query: 379 NLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKG 435
+ + K + K++ V PPR G S+ G V + T++
Sbjct: 497 SASMASDFRKRR--KSEPAVGPPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSS 553
Query: 436 EDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTS 495
+ S + L + RS P + P P A ++DF A+ +L+
Sbjct: 554 PSRAKDRESPRSYSSTLTDMGRSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKK 610
Query: 496 GEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVA 555
G+ VY+L KID +WY G ++GIFP +YV+ + PE R + + +A
Sbjct: 611 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIA 669
Query: 556 RFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------E 606
++ + + ELS +G+ +IL + V++ W G++ G R GIFP+++VE V E
Sbjct: 670 KYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAE 729
Query: 607 DYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 659
DYP S + S + + N Q P +AL+++T D+L
Sbjct: 730 DYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELEL 786
Query: 660 KRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
+ D I ++E+ D W G + + G FP +V+
Sbjct: 787 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 522 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 581
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 563 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 620
Query: 582 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 641
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 621 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 663
Query: 642 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 697
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 664 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 723
Query: 698 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 725
K S+ + P+ G +ALY++ NEDE
Sbjct: 724 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 783
Query: 726 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 764
L + D+I +E DD W G G FP NY++ L
Sbjct: 784 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 590 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 646
Query: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 647 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 706
Query: 752 --KSGIFPKNYIQFLQ 765
+ GIFP +Y++ ++
Sbjct: 707 TNRQGIFPVSYVEVVK 722
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 114 bits (284), Expect = 4e-25
Identities = 116/456 (25%), Positives = 192/456 (42%), Gaps = 54/456 (11%)
Query: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
+PGK + PPPLP T + + L S+ G+ G PPR
Sbjct: 302 EPGKSSILQHERPPPLP----------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR- 350
Query: 324 PPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQS 378
+G P+ + P + P RPP L + + + FN +SS D L++ S
Sbjct: 351 -----SGAPTPSSRAPA-LSPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMS 403
Query: 379 NLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKG 435
+ + K + K++ V PPR G S+ G V + T++
Sbjct: 404 SASMASDFRKRR--KSEPAVGPPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSS 460
Query: 436 EDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTS 495
+ S + L + RS P + P P A ++DF A+ +L+
Sbjct: 461 PSRAKDRESPRSYSSTLTDMGRSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKK 517
Query: 496 GEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVA 555
G+ VY+L KID +WY G ++GIFP +YV+ + PE R + + +A
Sbjct: 518 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIA 576
Query: 556 RFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------E 606
++ + + ELS +G+ +IL + V++ W G++ G R GIFP+++VE V E
Sbjct: 577 KYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAE 636
Query: 607 DYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 659
DYP S + S + + N Q P +AL+++T D+L
Sbjct: 637 DYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELEL 693
Query: 660 KRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
+ D I ++E+ D W G + + G FP +V+
Sbjct: 694 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 522 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 581
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 470 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 527
Query: 582 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 641
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 528 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 570
Query: 642 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 697
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 571 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 630
Query: 698 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 725
K S+ + P+ G +ALY++ NEDE
Sbjct: 631 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 690
Query: 726 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 764
L + D+I +E DD W G G FP NY++ L
Sbjct: 691 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 497 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 553
Query: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 554 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 613
Query: 752 --KSGIFPKNYIQFLQ 765
+ GIFP +Y++ ++
Sbjct: 614 TNRQGIFPVSYVEVVK 629
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 112 bits (281), Expect = 1e-24
Identities = 158/732 (21%), Positives = 271/732 (37%), Gaps = 125/732 (17%)
Query: 49 SSGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPN 108
S+ +P V P + GT G P P + + P+T P L
Sbjct: 121 SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP 180
Query: 109 PGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAP--LKPVTV 166
P L R + P R SG P P S S P P AP L+ V+
Sbjct: 181 PHLQRWPHHSQPARA-------SGSFAPISQTPP-----SFSPPPPLVPPAPEDLRRVSE 228
Query: 167 PPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPT---PSGNLAEE 223
P S + L E V LI D P+ PS
Sbjct: 229 PDLTGAVSSTDSSPLLNE----------------VSSSLIGTDSQAFPSVSKPSSAYPST 272
Query: 224 SVGSEMVL-------DPFQLPAKTEPIKERAV---QPAPTRKPTVIRIPAKPGKCLHEDP 273
++ + ++ +L + ++P+ ER V APT++ P PGK + +
Sbjct: 273 TIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEK-----PTSPGKAIEKRA 327
Query: 274 QSPPPLPAEK--------------PIGNT------FSTVSGKLSNVERTRNLESNHPGQT 313
+ + P+ NT + T+ ++ + R + + P +
Sbjct: 328 KDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYS 387
Query: 314 GGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDL 373
P PR + + + K P P + S+ + S+++ + +D
Sbjct: 388 FSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDT 447
Query: 374 QKKQSNLAT--GLSKAKSQVFKNQ--DPVLPPRPK-----PGHPLYSKYMR--------- 415
+K ++ + KS V N+ + P P+ PG+ S +
Sbjct: 448 RKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAP 507
Query: 416 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSH---------- 465
GD L L+ Y +G D LS +K P P H
Sbjct: 508 GD-LTSLENERQIYKSVLEGGDIPLQGLSGLK--RPSSSASTKDSESPRHFIPADYLEST 564
Query: 466 ----AQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIF 521
++ D A DF A+ + +L L G+IVY+ ++ID +WY G ++GIF
Sbjct: 565 EEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIF 624
Query: 522 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 581
P Y++++ P ++ ++ +A+F + G+ + E+SF +GE I L V
Sbjct: 625 PRTYIELL--PPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 682
Query: 582 NEEWARGEVRG--RTGIFPLNFVEPVE-----------DYPTSG----ANVLSTKVPLKT 624
+E W G + G R GIFP+ +V+ ++ D P S + S + P
Sbjct: 683 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQ 742
Query: 625 KKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQD 682
++ + SQ + + +AL+S+ + D+L + GD + ++E+ D W G R
Sbjct: 743 QRRVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 801
Query: 683 REGIFPAVFVRP 694
+ G FP +V+P
Sbjct: 802 QFGTFPGNYVKP 813
Score = 92.4 bits (228), Expect = 1e-18
Identities = 176/823 (21%), Positives = 301/823 (36%), Gaps = 150/823 (18%)
Query: 38 TPRSLPPKPTVS---SGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAG 94
TP S P P + KP + P+P++ + EW RL ++ P A
Sbjct: 50 TPSSSPASPQETRQHESKPGLEPEPSS---ADEW------RLSSSADANGNAQPSSLAAK 100
Query: 95 SIPVTKPELPKKPNPGLIRS--VNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSE 152
P LP + S PE+ ++D G++ P PL V
Sbjct: 101 GYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCV--- 157
Query: 153 NPTYPS--APLKPVT-------VPPRLAG-------ASQAKAYKSLGEGPPANPPVPVLQ 196
PT P+ + P+T +PP L A + ++ + + PP+ P P L
Sbjct: 158 -PTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLV 216
Query: 197 SKPLVDIDLISFDD---DVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQPAPT 253
D+ +S D V T S L E S + D P+ ++P + P+ T
Sbjct: 217 PPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKP---SSAYPSTT 273
Query: 254 R-KPTVIRI---------------PAKPGKCLHED--PQSPPPLPAEKPIGNTFSTVSGK 295
PT++ + P + +D P P K I S +
Sbjct: 274 IVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRR 333
Query: 296 LSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNG-KTIPTQQPPTKVPPERPP-PPKLS 353
+ V+ T++L + G +P R R + KT+ Q + P+ S
Sbjct: 334 V--VKSTQDLSDVSMDEVG----IPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYS 387
Query: 354 ATRRSNKKLPFNRSSSDM---DLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLY 410
+ + L RS S+M D +K AT A+S K+ P
Sbjct: 388 FSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDT 447
Query: 411 SKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRP----NDPSHA 466
KY + + E Q G+ + + I+P E P + HA
Sbjct: 448 RKY---------RAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHA 498
Query: 467 QKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYL----LEKIDTDWYRGNCRNQIGIFP 522
K GAP + + Q+ L G+I L++ + + + P
Sbjct: 499 VKRESDGAPGDLTSLE-NERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIP 557
Query: 523 ANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 582
A+Y++ + + +E + A+F++ + EL +G+I+ + + ++
Sbjct: 558 ADYLESTEEFIRRRHDDKEMRPAR--------AKFDFKAQTLKELPLQKGDIVYIYKQID 609
Query: 583 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 642
+ W GE GR GIFP ++E + +K + V L
Sbjct: 610 QNWYEGEHHGRVGIFPRTYIELLP----------------PAEKAQPKKLTPVQVLEYGE 653
Query: 643 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRL--QDREGIFPAVFV----RP-- 694
A +F +T ++SF++G+RI +L ++D +W GR+ R+GIFP +V RP
Sbjct: 654 AIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLV 713
Query: 695 -------------CPAEAKSMLAIVPKGRKAK----------------ALYDFRGENEDE 725
P+ + + P+ ++ + ALY + +N+DE
Sbjct: 714 KNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDE 773
Query: 726 LSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 766
L + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 774 LELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 107 bits (268), Expect = 3e-23
Identities = 132/606 (21%), Positives = 239/606 (39%), Gaps = 101/606 (16%)
Query: 176 AKAYKSLGEGPPANPPVPVLQSKPL---VDIDLISFDDDVLPT---PSGNLAEESVGSEM 229
AK Y+S+ P++ S PL V LI D P+ PS ++ +
Sbjct: 90 AKGYRSVHPNLPSDKSQ---DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPT 146
Query: 230 VL-------DPFQLPAKTEPIKERAV---QPAPTRKPTVIRIPAKPGKCLHEDPQSPPPL 279
++ +L + ++P+ ER V APT++ P PGK + + +
Sbjct: 147 IVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEK-----PTSPGKAIEKRAKDDSRR 201
Query: 280 PAEK--------------PIGNT------FSTVSGKLSNVERTRNLESNHPGQTGGFVRV 319
+ P+ NT + T+ ++ + R + + P +
Sbjct: 202 VVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTK 261
Query: 320 PPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSN 379
P PR + + + K P P + S+ + S+++ + +D +K ++
Sbjct: 262 SPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 321
Query: 380 LAT--GLSKAKSQVFKNQ--DPVLPPRPK-----PGHPLYSKYMR---------GDVLVM 421
+ KS V N+ + P P+ PG+ S + GD L
Sbjct: 322 PKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGD-LTS 380
Query: 422 LKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSH--------------AQ 467
L+ Y +G D LS +K P P H +
Sbjct: 381 LENERQIYKSVLEGGDIPLQGLSGLK--RPSSSASTKDSESPRHFIPADYLESTEEFIRR 438
Query: 468 KPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVK 527
+ D A DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++
Sbjct: 439 RHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 498
Query: 528 VIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWAR 587
++ P ++ ++ +A+F + G+ + E+SF +GE I L V+E W
Sbjct: 499 LL--PPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYE 556
Query: 588 GEVRG--RTGIFPLNFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSG 630
G + G R GIFP+ +V+ ++ D P S + S + P ++ +
Sbjct: 557 GRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 616
Query: 631 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFP 688
SQ + + +AL+S+ + D+L + GD + ++E+ D W G R + G FP
Sbjct: 617 DRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFP 675
Query: 689 AVFVRP 694
+V+P
Sbjct: 676 GNYVKP 681
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 450 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 501
Query: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 502 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 553
Query: 675 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 713
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 554 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 613
Query: 714 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 755
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 614 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 673
Query: 756 FPKNYIQFLQI 766
FP NY++ L +
Sbjct: 674 FPGNYVKPLYL 684
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 466 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 520
Query: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 529
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 521 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 579
Query: 530 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 564
+D+P + R +S V R A + YI +
Sbjct: 580 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 639
Query: 565 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 640 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/55 (40%), Positives = 34/55 (61%)
Query: 710 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
R A+A +DF+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 446 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 500
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 541
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 509 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 566
Query: 542 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 599
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 567 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 626
Query: 600 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 644
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 627 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 685
Query: 645 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 694
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 686 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 737
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 557
Query: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 558 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 609
Query: 675 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 713
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 610 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 669
Query: 714 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 755
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 670 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 729
Query: 756 FPKNYIQFLQI 766
FP NY++ L +
Sbjct: 730 FPGNYVKPLYL 740
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 522 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 576
Query: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 529
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 577 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 635
Query: 530 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 564
+D+P + R +S V R A + YI +
Sbjct: 636 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 695
Query: 565 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 696 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 15/167 (8%)
Query: 607 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQ 666
D P G + L + K+ S S + +PA++ E+ F DD D+ +
Sbjct: 396 DIPLQGLSGLKRPSSSASTKD---SESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 452
Query: 667 IL-ERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRK--------AKALYD 717
+ E+ ++D R G+ P +L I ++ A+A +D
Sbjct: 453 LKREQEEADIAARR---HTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 509
Query: 718 FRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
F+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 510 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 556
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 541
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 550 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 607
Query: 542 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 599
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 608 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 667
Query: 600 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 644
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 668 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 726
Query: 645 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 694
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 727 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 778
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 598
Query: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 599 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 650
Query: 675 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 713
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 651 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 710
Query: 714 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 755
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 711 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 770
Query: 756 FPKNYIQFLQI 766
FP NY++ L +
Sbjct: 771 FPGNYVKPLYL 781
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 563 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 617
Query: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 529
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 618 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 676
Query: 530 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 564
+D+P + R +S V R A + YI +
Sbjct: 677 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 736
Query: 565 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 737 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 15/167 (8%)
Query: 607 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQ 666
D P G + L + K+ S S + +PA++ E+ F DD D+ +
Sbjct: 437 DIPLQGLSGLKRPSSSASTKD---SESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 493
Query: 667 IL-ERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRK--------AKALYD 717
+ E+ ++D R G+ P +L I ++ A+A +D
Sbjct: 494 LKREQEEADIAARR---HTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 550
Query: 718 FRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
F+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 551 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 597
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 105 bits (263), Expect = 1e-22
Identities = 115/459 (25%), Positives = 194/459 (42%), Gaps = 49/459 (10%)
Query: 273 PQSPPPLPAEKPIGNTFSTVSGKLSNVER---TRNLESN-------HPGQTGGFVRVPP- 321
P PPP+P +P + ST +R TR S PG++ P
Sbjct: 217 PHVPPPVPPLRPRDRS-STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPT 275
Query: 322 -RLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQK 375
R+ P ++ + P + +++ RPPP K + + FN +SS D L++
Sbjct: 276 DRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLER 335
Query: 376 KQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLEC 432
S+ + K + K++ V PPR G S+ G V + T++
Sbjct: 336 PMSSASMASDFRKRR--KSEPAVGPPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSS 392
Query: 433 QKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLN 492
+ S + L + RS P + P P A ++DF A+ +L+
Sbjct: 393 PSSPSRAKDRESPRSYSSTLTDMGRSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELS 449
Query: 493 LTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSR 552
G+ VY+L KID +WY G ++GIFP +YV+ + PE R + +
Sbjct: 450 FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGE 508
Query: 553 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPV----- 605
+A++ + + ELS +G+ +IL + V++ W G++ G R GIFP+++VE V
Sbjct: 509 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 568
Query: 606 --EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDD 656
EDYP S + S + + N Q P +AL+++T D+
Sbjct: 569 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDE 625
Query: 657 LSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
L + D I ++E+ D W G + + G FP +V+
Sbjct: 626 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 664
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 522 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 581
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 405 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 462
Query: 582 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 641
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 463 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 505
Query: 642 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 697
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 506 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 565
Query: 698 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 725
K S+ + P+ G +ALY++ NEDE
Sbjct: 566 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 625
Query: 726 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 764
L + D+I +E DD W G G FP NY++ L
Sbjct: 626 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 432 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 488
Query: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 489 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 548
Query: 752 --KSGIFPKNYIQFLQ 765
+ GIFP +Y++ ++
Sbjct: 549 TNRQGIFPVSYVEVVK 564
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 105 bits (262), Expect = 2e-22
Identities = 112/445 (25%), Positives = 175/445 (39%), Gaps = 51/445 (11%)
Query: 336 QQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQ 395
++P P E+P P R +L +L K + T L KS +
Sbjct: 256 KKPLVDDPGEKPSQPIEVLLERELAEL-------SAELDKDLRAIETRLPSPKSSPAPRR 308
Query: 396 DPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEH 455
P P P S Y L + L K D G L + + P
Sbjct: 309 APEQRPPAGPASAWSSSYPHAPYLGSARS-----LSPHKMADGGSPFLGRRDFVYPSSTR 363
Query: 456 LRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR 515
S N + + A + DF A+ +L L G+IVY+ +++D +W G
Sbjct: 364 DPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHH 423
Query: 516 NQIGIFPANYVKVI--IDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGE 573
++GIFPANYV+V+ +IP+ + + ++ VA++ + G+ + ELSF +GE
Sbjct: 424 GRLGIFPANYVEVLPADEIPK----PIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGE 479
Query: 574 IIILKEYVNEEWARGEV--RGRTGIFPLNFV----EP----VEDYPTSGANVLSTKVPLK 623
I L VNE W G + GR GIFP ++V EP +D P + T
Sbjct: 480 HICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARS 539
Query: 624 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 683
+ S S + + P + L T+ SF + R + Q+
Sbjct: 540 ARHPSSPSALRSPADPID----LGGQTSPRRTGFSFPTQEP------------RPQTQNL 583
Query: 684 EGIFPAVFVRPCPAEAKSMLAIVPKGRKA-----KALYDFRGENEDELSFKAGDIITELE 738
PA+ P+ + P + +A+Y +R +NEDEL + GD + ++
Sbjct: 584 GTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQ 643
Query: 739 SVDDDWMSG--ELMGKSGIFPKNYI 761
DD W G K G FP NY+
Sbjct: 644 QCDDGWFVGVSRRTQKFGTFPGNYV 668
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 649 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 703
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 391 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 450
Query: 704 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 761
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 451 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 510
Query: 762 Q 762
Q
Sbjct: 511 Q 511
Score = 68.2 bits (165), Expect = 3e-11
Identities = 101/462 (21%), Positives = 170/462 (36%), Gaps = 76/462 (16%)
Query: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
+P K L +DP P P E + + +S +L R + RL
Sbjct: 254 RPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRA----------------IETRL 297
Query: 324 PPRPVNGKTIPTQQP-PTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT 382
P P P P + P +RPP SA S P+ S+ + K +
Sbjct: 298 PS--------PKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMADGGSP 349
Query: 383 ---------------------GLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLVM 421
G S A+ + K + L + P +GD++ +
Sbjct: 350 FLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYI 409
Query: 422 LKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLH 481
K+ + N+LE GE GR+ + + L +P P Q ++ G AV +
Sbjct: 410 HKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQV-LEYG--EAVAQY 463
Query: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN--QIGIFPANYVKVIIDIPEGGNGK 539
F + +L+ GE + L+ K++ +WY G + GIFPA+YV+V
Sbjct: 464 TFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV----------S 513
Query: 540 RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPL 599
RE C G + + S L+ + G+ R F
Sbjct: 514 REPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRSPADPIDLGGQTSPRRTGFSF 571
Query: 600 NFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWC--EALHSFTAETS 654
EP ++ T G + ++ P + D G++S N+ W A++ + +
Sbjct: 572 PTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-NTSQIHWTPYRAMYQYRPQNE 628
Query: 655 DDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 694
D+L + GDR+ ++++ D W G R + G FP +V P
Sbjct: 629 DELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 670
Score = 52.4 bits (124), Expect = 2e-06
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 708 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 381 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 437
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 105 bits (261), Expect = 2e-22
Identities = 80/327 (24%), Positives = 140/327 (42%), Gaps = 43/327 (13%)
Query: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV---------- 526
A+V D+ A+ D+L ++ GEI+ + K D W+ G + G+FP N+V
Sbjct: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
Query: 527 --------KVIIDIPEGGNGKRECVSSHCV---------KGSRCVARFEYIGEQKDELSF 569
K + ++P G + +SS + + RC F Y+ + DEL
Sbjct: 64 PLTNKAPEKPLHEVPSGNS----LLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELEL 119
Query: 570 SEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDS 629
G+II + V E W G + G+TG+FP NF++ + ++ + +E +
Sbjct: 120 KVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETT 179
Query: 630 GSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPA 689
GS S + E + A + +G + + R R + E F
Sbjct: 180 GSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLP 239
Query: 690 V---------FVRPCPAEAKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDIITEL-- 737
V P +K+ + K + K ++ + +N+DEL+ K GDI+T +
Sbjct: 240 VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINK 299
Query: 738 ESVDDDWMSGELMGKSGIFPKNYIQFL 764
+ +D W GEL G+ G+FP N+++ L
Sbjct: 300 DCIDVGWWEGELNGRRGVFPDNFVKLL 326
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/227 (22%), Positives = 99/227 (43%), Gaps = 29/227 (12%)
Query: 489 DDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII-DIPEGGNGKRECVSSHC 547
D+L L G+I+ ++ +++ W+ G + G+FP+N++K + + E G + E +S
Sbjct: 115 DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSS 174
Query: 548 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR----TGIFPLNFVE 603
++ E G + D S + E N A ++ + G + +
Sbjct: 175 LR--------ETTGSESDGGDSSSTK----SEGANGTVATAAIQPKKVKGVGFGDIFKDK 222
Query: 604 PVEDYPTS---------GANVLSTKVPLKTKKEDSGSNSQVNSLPA-EWCEALHSFTAET 653
P++ P S + K+P T DS + + ++C+ + + A+
Sbjct: 223 PIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQN 282
Query: 654 SDDLSFKRGDRIQILER--LDSDWCRGRLQDREGIFPAVFVRPCPAE 698
D+L+ K GD + ++ + +D W G L R G+FP FV+ P +
Sbjct: 283 DDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPD 329
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/107 (30%), Positives = 52/107 (48%), Gaps = 7/107 (6%)
Query: 553 CVARFEYIGEQKDELSFSEGEIIIL--KEYVNEEWARGEVRGRTGIFPLNFVEPV-EDYP 609
C F Y + DEL+ EG+I+ L K+ ++ W GE+ GR G+FP NFV+ + D+
Sbjct: 272 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFE 331
Query: 610 TSGANVLSTKVP-LKTKKEDSGSNS---QVNSLPAEWCEALHSFTAE 652
G P K+ +G+ ++ +P E E L + T E
Sbjct: 332 KEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEE 378
Score = 43.9 bits (102), Expect = 6e-04
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 6/81 (7%)
Query: 463 PSHAQKPVDS---GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEK--IDTDWYRGNCRNQ 517
P ++ +DS + V+ + A+ D+L + G+IV L+ K ID W+ G +
Sbjct: 255 PDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR 314
Query: 518 IGIFPANYVKVI-IDIPEGGN 537
G+FP N+VK++ D + GN
Sbjct: 315 RGVFPDNFVKLLPPDFEKEGN 335
Score = 34.3 bits (77), Expect = 0.45
Identities = 47/179 (26%), Positives = 67/179 (37%), Gaps = 23/179 (12%)
Query: 236 LPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGK 295
LP E R +P P P VI+ A + HE + PP P P + +
Sbjct: 326 LPPDFEKEGNRPKKPPPPSAP-VIKQGAGTTERKHEIKKIPPERPEMLP------NRTEE 378
Query: 296 LSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPP--KLS 353
ER L+ P +PP+ P P KT +P +PP RP P L+
Sbjct: 379 KERPEREPKLDLQKPSVPA----IPPKKPRPP---KTNSLSRPGA-LPPRRPERPVGPLT 430
Query: 354 ATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSK 412
TR + K+ SS L K S+ + + + D V+ K HP S+
Sbjct: 431 HTRGDSPKIDLAGSSLSGILDKDLSDRSNDID------LEGFDSVVSSTEKLSHPTTSR 483
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 103 bits (258), Expect = 5e-22
Identities = 98/375 (26%), Positives = 163/375 (43%), Gaps = 36/375 (9%)
Query: 345 ERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVL 399
ERPPP K + + FN +SS D L++ S+ + K + K++ V
Sbjct: 295 ERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR--KSEPAVG 352
Query: 400 PPRPKPGHPLYSKYMRGDVLV---MLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL 456
PPR G S+ G V + T++ + S + L +
Sbjct: 353 PPRGL-GDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMG 411
Query: 457 RSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN 516
RS P + P P A ++DF A+ +L+ G+ VY+L KID +WY G
Sbjct: 412 RSAPRE--RRGTPEKEKLP-AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHG 468
Query: 517 QIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIII 576
++GIFP +YV+ + PE R + + +A++ + + ELS +G+ +I
Sbjct: 469 RVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVI 527
Query: 577 LKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKV 620
L + V++ W G++ G R GIFP+++VE V EDYP S + S
Sbjct: 528 LLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSS 587
Query: 621 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRL 680
+ + N Q P +AL+++T D+L + D I ++E+ D W G
Sbjct: 588 NKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 644
Query: 681 QDRE--GIFPAVFVR 693
+ + G FP +V+
Sbjct: 645 RRTKFFGTFPGNYVK 659
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 522 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 581
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 400 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 457
Query: 582 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 641
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 458 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 500
Query: 642 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 697
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 501 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 560
Query: 698 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 725
K S+ + P+ G +ALY++ NEDE
Sbjct: 561 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 620
Query: 726 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 764
L + D+I +E DD W G G FP NY++ L
Sbjct: 621 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 427 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483
Query: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 484 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 543
Query: 752 --KSGIFPKNYIQFLQ 765
+ GIFP +Y++ ++
Sbjct: 544 TNRQGIFPVSYVEVVK 559
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 536
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 260 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 318
Query: 537 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 594
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 319 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 378
Query: 595 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 640
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 379 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 437
Query: 641 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 438 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 522 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 581
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 231 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 288
Query: 582 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 641
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 289 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 331
Query: 642 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 697
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 332 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 391
Query: 698 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 725
K S+ + P+ G +ALY++ NEDE
Sbjct: 392 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 451
Query: 726 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 764
L + D+I +E DD W G G FP NY++ L
Sbjct: 452 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 258 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314
Query: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 315 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 374
Query: 752 --KSGIFPKNYIQFLQ 765
+ GIFP +Y++ ++
Sbjct: 375 TNRQGIFPVSYVEVVK 390
Score = 73.9 bits (180), Expect = 5e-13
Identities = 87/395 (22%), Positives = 157/395 (39%), Gaps = 62/395 (15%)
Query: 252 PTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPG 311
P RK + ++P +P L E+P S++ L + ++ S+
Sbjct: 115 PDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK 174
Query: 312 QTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSAT--RRSNKKLPFNRS-S 368
+ P PPR + Q ++ P R P S T + P + S +
Sbjct: 175 RRKS---EPAVGPPRGLG------DQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRA 225
Query: 369 SDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPK-PGHPLYS---------KYMRGDV 418
D + + S+ T + ++ + + P + K P +Y + +GD
Sbjct: 226 KDRESPRSYSSTLTDMGRSAPRERRGT----PEKEKLPAKAVYDFKAQTSKELSFKKGDT 281
Query: 419 LVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV 478
+ +L++ + N+ E GE GRV + + + L +++P P +P + G A+
Sbjct: 282 VYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIG--EAI 336
Query: 479 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVIIDIPEGG 536
++F A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+ +G
Sbjct: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 396
Query: 537 NGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKDELSFSE 571
+ H R A + Y +DEL E
Sbjct: 397 EDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRE 456
Query: 572 GEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 603
++I + E ++ W G R RT G FP N+V+
Sbjct: 457 SDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 490
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 536
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 772 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 830
Query: 537 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 594
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 831 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 890
Query: 595 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 640
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 891 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 949
Query: 641 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 950 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 522 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 581
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 743 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 800
Query: 582 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 641
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 801 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 843
Query: 642 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 697
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 844 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 903
Query: 698 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 725
K S+ + P+ G +ALY++ NEDE
Sbjct: 904 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 963
Query: 726 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 764
L + D+I +E DD W G G FP NY++ L
Sbjct: 964 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 770 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826
Query: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 827 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 886
Query: 752 --KSGIFPKNYIQFLQ 765
+ GIFP +Y++ ++
Sbjct: 887 TNRQGIFPVSYVEVVK 902
Score = 72.8 bits (177), Expect = 1e-12
Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 36/221 (16%)
Query: 413 YMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 472
+ +GD + +L++ + N+ E GE GRV + + + L +++P P +P +
Sbjct: 788 FKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 844
Query: 473 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 530
G A+ ++F A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+
Sbjct: 845 G--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 902
Query: 531 DIPEGGNGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKD 565
+G + H R A + Y +D
Sbjct: 903 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 962
Query: 566 ELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 603
EL E ++I + E ++ W G R RT G FP N+V+
Sbjct: 963 ELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 1002
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/96 (38%), Positives = 50/96 (52%), Gaps = 15/96 (15%)
Query: 678 GRLQDREGIFPAVFV-------RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSF 728
G LQDRE P + R P E + P+ K AKA+YDF+ + ELSF
Sbjct: 735 GALQDRES--PRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSF 788
Query: 729 KAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
K GD + L +D +W GE G+ GIFP +Y++ L
Sbjct: 789 KKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 824
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 536
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 412 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 470
Query: 537 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 594
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 471 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 530
Query: 595 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 640
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 531 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 589
Query: 641 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 590 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 522 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 581
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 383 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 440
Query: 582 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 641
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 441 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 483
Query: 642 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 697
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 484 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 543
Query: 698 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 725
K S+ + P+ G +ALY++ NEDE
Sbjct: 544 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 603
Query: 726 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 764
L + D+I +E DD W G G FP NY++ L
Sbjct: 604 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 410 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
Query: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 467 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 526
Query: 752 --KSGIFPKNYIQFLQ 765
+ GIFP +Y++ ++
Sbjct: 527 TNRQGIFPVSYVEVVK 542
Score = 74.7 bits (182), Expect = 3e-13
Identities = 114/542 (21%), Positives = 199/542 (36%), Gaps = 110/542 (20%)
Query: 117 PEIPGRGPLAESSDSGKKVPTPAPRP-----LLLKKSVSSENPTYPSAPLKPVTVPPRLA 171
P PG GP+ ES + T RP + K+ P + P + P
Sbjct: 156 PHYPGIGPVDESGIP-TAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNPPYSAQSHP---- 210
Query: 172 GASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVL 231
A++ + Y+ L + N P +F D P P
Sbjct: 211 -AAKTQTYRPLSKSHSDNSPN--------------AFKDASSPVP--------------- 240
Query: 232 DPFQLPAKTEPIKERAVQPA-------PTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKP 284
P +P P++ R P RK + ++P +P L E+P
Sbjct: 241 -PPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERP 299
Query: 285 IGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPP 344
S++ L + ++ S+ + P PPR + Q ++ P
Sbjct: 300 ASLYQSSIDRSLERPMSSASMASDFRKRRKS---EPAVGPPRGLG------DQSASRTSP 350
Query: 345 ERPPPPKLSAT--RRSNKKLPFNRS-SSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPP 401
R P S T + P + S + D + + S+ T + ++ + + P
Sbjct: 351 GRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT----PE 406
Query: 402 RPK-PGHPLYS---------KYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITP 451
+ K P +Y + +GD + +L++ + N+ E GE GRV + + +
Sbjct: 407 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEK 463
Query: 452 LDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYR 511
L +++P P +P + G A+ ++F A+ +L+L G+ V LL+++D +WY
Sbjct: 464 LTPPEKAQPARPPPPAQPGEIG--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYE 521
Query: 512 GNC--RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRC---------------- 553
G N+ GIFP +YV+V+ +G + H R
Sbjct: 522 GKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHE 581
Query: 554 ---------VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNF 601
A + Y +DEL E ++I + E ++ W G R RT G FP N+
Sbjct: 582 NIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNY 640
Query: 602 VE 603
V+
Sbjct: 641 VK 642
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 536
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 868 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 926
Query: 537 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 594
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 927 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 986
Query: 595 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 640
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 987 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 1045
Query: 641 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 693
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 1046 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 522 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 581
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 839 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 896
Query: 582 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 641
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 897 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 939
Query: 642 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 697
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 940 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 999
Query: 698 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 725
K S+ + P+ G +ALY++ NEDE
Sbjct: 1000 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 1059
Query: 726 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 764
L + D+I +E DD W G G FP NY++ L
Sbjct: 1060 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 866 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922
Query: 698 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 751
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 923 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 982
Query: 752 --KSGIFPKNYIQFLQ 765
+ GIFP +Y++ ++
Sbjct: 983 TNRQGIFPVSYVEVVK 998
Score = 72.8 bits (177), Expect = 1e-12
Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 36/221 (16%)
Query: 413 YMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 472
+ +GD + +L++ + N+ E GE GRV + + + L +++P P +P +
Sbjct: 884 FKKGDTVYILRKIDQNWYE---GEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEI 940
Query: 473 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 530
G A+ ++F A+ +L+L G+ V LL+++D +WY G N+ GIFP +YV+V+
Sbjct: 941 G--EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 998
Query: 531 DIPEGGNGKRECVSSHCVKGSRC-------------------------VARFEYIGEQKD 565
+G + H R A + Y +D
Sbjct: 999 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 1058
Query: 566 ELSFSEGEIIILKEYVNEEWARGEVRGRT---GIFPLNFVE 603
EL E ++I + E ++ W G R RT G FP N+V+
Sbjct: 1059 ELELRESDVIDVMEKCDDGWFVGTSR-RTKFFGTFPGNYVK 1098
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/96 (38%), Positives = 50/96 (52%), Gaps = 15/96 (15%)
Query: 678 GRLQDREGIFPAVFV-------RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSF 728
G LQDRE P + R P E + P+ K AKA+YDF+ + ELSF
Sbjct: 831 GALQDRES--PRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSF 884
Query: 729 KAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
K GD + L +D +W GE G+ GIFP +Y++ L
Sbjct: 885 KKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 920
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 99.8 bits (247), Expect = 9e-21
Identities = 70/241 (29%), Positives = 107/241 (44%), Gaps = 25/241 (10%)
Query: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDT-DWYRGNCRNQIGIFPANYVKVIIDIPEGG 536
+VL + A++ D+L+L G++V + + W RG + G+FP V+ +IPE
Sbjct: 4 LVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQ---EIPETL 60
Query: 537 NGKRECVSSHCVKGSR-----------CVARFEYIGEQKDELSFSEGEIIILKEYVNEEW 585
G E C + C F Y EQ DEL GEI+ + + + + W
Sbjct: 61 RGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGW 120
Query: 586 ARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP------ 639
G+ G+ G FP NFVE ++ P S N V ++ S+ +S P
Sbjct: 121 WLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
Query: 640 --AEWCEALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRLQDREGIFPAVFVRPC 695
E L + E D+L+ +RGD +++L + D W G Q R G+FP FV P
Sbjct: 181 SHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPP 240
Query: 696 P 696
P
Sbjct: 241 P 241
Score = 88.2 bits (217), Expect = 3e-17
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 38/235 (16%)
Query: 559 YIGEQKDELSFSEGEIIILKEYVNEE-WARGEVRGRTGIFPLNFVEPVEDYPTSGANVLS 617
Y +++DELS + G+++ +V W RGE GR G+FP V+ + +
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 618 TKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCR 677
+ + + + P WC+ S++ E +D+L + G+ +++++ ++ W
Sbjct: 69 PRCARRR------GHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWL 122
Query: 678 GRLQDREGIFPAVFVR------------------PCPAEAKSM-----------LAIVPK 708
G+ + G FP+ FV P P + L V
Sbjct: 123 GKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSH 182
Query: 709 GRKAKALYDFRGENEDELSFKAGDIITELESVDDD--WMSGELMGKSGIFPKNYI 761
+ L+D++ E DEL+ + GD++ L +D W GE G+ G+FP N++
Sbjct: 183 PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237
Score = 60.8 bits (146), Expect = 4e-09
Identities = 37/135 (27%), Positives = 63/135 (46%), Gaps = 16/135 (11%)
Query: 646 LHSFTAETSDDLSFKRGDRIQILERLDS-DWCRGRLQDREGIFPAVFVRPCP------AE 698
L + A+ D+LS GD ++ + + + W RG R G+FP V+ P E
Sbjct: 6 LAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGE 65
Query: 699 AKSMLAIVPKGRKAK---------ALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL 749
A+ +G AK + + E DEL +AG+I+ ++ ++D W G+
Sbjct: 66 ARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKK 125
Query: 750 MGKSGIFPKNYIQFL 764
G+ G FP N+++ L
Sbjct: 126 NGQLGAFPSNFVELL 140
Score = 35.0 bits (79), Expect = 0.26
Identities = 56/233 (24%), Positives = 93/233 (39%), Gaps = 38/233 (16%)
Query: 135 VPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPV 194
+P P + L+ +K VS E SAP+K P +L + K L P
Sbjct: 238 LPPPPIKKLVPRKVVSRE-----SAPIKE---PKKLMPKTSLPTVKKLATAT-TGPSKAK 288
Query: 195 LQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQP---- 250
P D ++ D P+G +S GS P + +KT+ ++R+V
Sbjct: 289 TSRTPSRDSQKLTSRDS---GPNGGF--QSGGS---YHPGRKRSKTQTPQQRSVSSQEEE 340
Query: 251 --APTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNL--E 306
+P + P+V R P E P +P P+ K I K+ + E+T L +
Sbjct: 341 HSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKI-----PAPDKVPSPEKTLTLGDK 395
Query: 307 SNHPG-QTGGFVRVPPRLPP-----RPVNGKTIPTQQ--PPTKVPPERPPPPK 351
++ PG T G + P ++P P + +IP P + ++P P+
Sbjct: 396 ASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPE 448
Score = 33.9 bits (76), Expect = 0.58
Identities = 71/362 (19%), Positives = 108/362 (29%), Gaps = 68/362 (18%)
Query: 29 SGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRASGE---WDSGTENRLKVTSKEGLT 85
+ LP ++ + P +S PS + +R SG + SG + T
Sbjct: 269 TSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQT 328
Query: 86 PYP----PLQEAGSIPVTKPELPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPR 141
P +E S PV P + + P P ++ PE P P E++ S KK+P P
Sbjct: 329 PQQRSVSSQEEEHSSPVKAPSVKRTPMPD--KTATPERP---PAPENAPSSKKIPAPDKV 383
Query: 142 PLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLV 201
P K + + P G P P
Sbjct: 384 PSPEKTLTLGDKASIP-------------------------GNSTSGKIPAP-------- 410
Query: 202 DIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQPAPTRKPTVIRI 261
D +PTP + E D +P + +E P+ V +
Sbjct: 411 ---------DKVPTPEKMVTPE--------DKASIPENSIIPEETLTVDKPSTPERVFSV 453
Query: 262 PAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPP 321
P L P P P P+G+ T+ L+ + + Q F
Sbjct: 454 EESP--ALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEA 511
Query: 322 RLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLA 381
+ K P+ Q P PP P S K R D +Q+ L
Sbjct: 512 LQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRG----DSSPRQAELK 567
Query: 382 TG 383
+G
Sbjct: 568 SG 569
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 99.8 bits (247), Expect = 9e-21
Identities = 91/344 (26%), Positives = 146/344 (42%), Gaps = 39/344 (11%)
Query: 437 DTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSG 496
D G L + + P S N + + A + DF A+ +L L G
Sbjct: 3 DGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKG 62
Query: 497 EIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNGKRECVSSHCVKGSRCV 554
+IVY+ +++D +W G ++GIFPANYV+V+ +IP+ + + ++ V
Sbjct: 63 DIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK----PIKPPTYQVLEYGEAV 118
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFV----EP---- 604
A++ + G+ + ELSF +GE I L VNE W G + GR GIFP ++V EP
Sbjct: 119 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRL 178
Query: 605 VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDR 664
+D P + T + S S + + P + L T+ SF +
Sbjct: 179 CDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID----LGGQTSPRRTGFSFPTQEP 234
Query: 665 IQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA-----KALYDFR 719
R + Q+ PA+ P+ + P + +A+Y +R
Sbjct: 235 ------------RPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYR 282
Query: 720 GENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYI 761
+NEDEL + GD + ++ DD W G K G FP NY+
Sbjct: 283 PQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 649 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 703
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 49 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 108
Query: 704 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 761
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 109 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 168
Query: 762 Q 762
Q
Sbjct: 169 Q 169
Score = 62.4 bits (150), Expect = 2e-09
Identities = 68/289 (23%), Positives = 120/289 (41%), Gaps = 30/289 (10%)
Query: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
+GD++ + K+ + N+LE GE GR+ + + L +P P Q ++ G
Sbjct: 61 KGDIVYIHKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQV-LEYG- 115
Query: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRN--QIGIFPANYVKVIIDI 532
AV + F + +L+ GE + L+ K++ +WY G + GIFPA+YV+V
Sbjct: 116 -EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV---- 170
Query: 533 PEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 592
RE C G + + S L+ + G+
Sbjct: 171 ------SREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRSPADPIDLGGQTSP 222
Query: 593 RTGIFPLNFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWC--EALH 647
R F EP ++ T G + ++ P + D G++S N+ W A++
Sbjct: 223 RRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-NTSQIHWTPYRAMY 279
Query: 648 SFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 694
+ + D+L + GDR+ ++++ D W G R + G FP +V P
Sbjct: 280 QYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 328
Score = 52.4 bits (124), Expect = 2e-06
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 708 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 39 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 95
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 99.0 bits (245), Expect = 1e-20
Identities = 68/251 (27%), Positives = 115/251 (45%), Gaps = 40/251 (15%)
Query: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 541
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 654 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 711
Query: 542 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 599
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 712 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 771
Query: 600 NFVEPVE-----------DYPTSGANVLSTKV------------PLKTKKEDSGSNSQV- 635
+V+ ++ D P S + S P T+ E S Q
Sbjct: 772 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQ 831
Query: 636 ----------NSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDR 683
S +AL+S+ + D+L + GD + ++E+ D W G R +
Sbjct: 832 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 891
Query: 684 EGIFPAVFVRP 694
G FP +V+P
Sbjct: 892 FGTFPGNYVKP 902
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 624 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 683
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 637 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 689
Query: 684 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 738
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 690 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 749
Query: 739 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 765
VD++W G + G S GIFP Y+ ++
Sbjct: 750 QVDENWYEGRIPGTSRQGIFPITYVDVIK 778
Score = 73.6 bits (179), Expect = 7e-13
Identities = 62/271 (22%), Positives = 108/271 (39%), Gaps = 75/271 (27%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 651 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 702
Query: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 703 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 754
Query: 675 WCRGRL--QDREGIFPAVFV----RPC------------------PAEAKSMLA------ 704
W GR+ R+GIFP +V RP A A L+
Sbjct: 755 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRA 814
Query: 705 -----------IVPKGRKAKALYDFRGENED----------------ELSFKAGDIITEL 737
+ P+ ++ + D ++D EL + GDI+ +
Sbjct: 815 GPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 874
Query: 738 ESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 766
E DD W G + G FP NY++ L +
Sbjct: 875 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 905
Score = 59.3 bits (142), Expect = 1e-08
Identities = 57/243 (23%), Positives = 101/243 (41%), Gaps = 58/243 (23%)
Query: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 667 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 721
Query: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 529
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 722 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
Query: 530 --------IDIPEGGNGKRECVSS-----HCVKGSRCV---------------------- 554
+D+P + R +S H ++ +
Sbjct: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
Query: 555 ----------ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFV 602
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V
Sbjct: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
Query: 603 EPV 605
+P+
Sbjct: 901 KPL 903
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 96.3 bits (238), Expect = 1e-19
Identities = 83/311 (26%), Positives = 144/311 (46%), Gaps = 30/311 (9%)
Query: 416 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAP 475
GD++ +L + +L +K + TG+ S ++I+T PS + G
Sbjct: 26 GDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI-----------PS-----LKEGER 69
Query: 476 HAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQIGIFPANYVKVIIDIPE 534
V + +F ++++D+L L G++V L W +G +C G FP++ V+ + +
Sbjct: 70 LFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQ 129
Query: 535 GGNGKRECVSSHCVKGSRCVAR--FEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 592
+ + S AR + +EL F EG++I + W GE+ G
Sbjct: 130 SRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG 189
Query: 593 RTGIFPLNFVE------PVEDYPTSGAN---VLSTKVPLKTKKEDSGSNSQVNSLPAEWC 643
R GIFP FVE V++ +SG +++ +V +E+ G + P +
Sbjct: 190 RRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEE-PGTYG 248
Query: 644 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCP-AEAKSM 702
AL+ F A ++L F+ GD+I+IL L+ W G L+ R GIFP FV+ CP +
Sbjct: 249 VALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEET 308
Query: 703 LAIVPKGRKAK 713
+A+ +G A+
Sbjct: 309 MALPQEGSLAR 319
Score = 94.7 bits (234), Expect = 3e-19
Identities = 82/316 (25%), Positives = 134/316 (42%), Gaps = 60/316 (18%)
Query: 480 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGK 539
+ DF ++L L G+I+ +L +D W G + G FP+++V+ I+ IP G+
Sbjct: 10 IFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVE-IVTIPSLKEGE 68
Query: 540 RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARG-EVRGRTGIFP 598
R V C+ E+ ++ D L G+++IL W +G G G FP
Sbjct: 69 RLFV---------CIC--EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFP 117
Query: 599 LNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP---AEWCEALHSFTAETSD 655
+ V ++ L ++ S S + +P AL +A+ +
Sbjct: 118 SSCVR---------------ELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDE 162
Query: 656 DLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR---PCPAEAKSMLA-------- 704
+L F+ GD I I+ + W G L+ R GIFP FV P +S+ +
Sbjct: 163 ELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIV 222
Query: 705 ------------IVP------KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMS 746
I P G ALY F+ +EL F+ GD I L +++D W+
Sbjct: 223 NGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLE 282
Query: 747 GELMGKSGIFPKNYIQ 762
G L G++GIFP +++
Sbjct: 283 GSLKGRTGIFPYRFVK 298
Score = 73.2 bits (178), Expect = 9e-13
Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 36/225 (16%)
Query: 550 GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 609
GS A F++ +EL G+II + V+E W G+ TG FP +FVE V
Sbjct: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT--- 60
Query: 610 TSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILE 669
+P S + L CE FT++ D+L RGD + +
Sbjct: 61 ----------IP---------SLKEGERLFVCICE----FTSQELDNLPLHRGDLVILDG 97
Query: 670 RLDSDWCRGR-LQDREGIFPAVFVRP-CPAE------AKSMLAIVPKGR--KAKALYDFR 719
+ W +GR G FP+ VR C + ++S L +P+ +A+AL
Sbjct: 98 IPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLS 157
Query: 720 GENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
+ ++EL F+ GD+IT + + W GEL G+ GIFP+ +++ L
Sbjct: 158 AQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELL 202
Score = 40.4 bits (93), Expect = 0.006
Identities = 19/58 (32%), Positives = 32/58 (55%)
Query: 709 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQI 766
G +A++DF +EL GDII L VD+ W+ G+ +G FP ++++ + I
Sbjct: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI 61
Score = 38.1 bits (87), Expect = 0.031
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Query: 697 AEAKSMLAIVPKGRKAK------ALYDFRGENEDELSFKAGDIITELESVD----DDWMS 746
A+A + P G +A+ A+Y F+ N +ELS A + LE D +W
Sbjct: 1497 AQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWL 1556
Query: 747 GELMGKSGIFPKNYIQ 762
E+ GK G P NYI+
Sbjct: 1557 AEVNGKKGYVPSNYIR 1572
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 90.5 bits (223), Expect = 5e-18
Identities = 90/329 (27%), Positives = 139/329 (42%), Gaps = 55/329 (16%)
Query: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTD-WYRGNCRNQIGIFPANYVKVI------- 529
+V +D+ A D+L + GEI+ ++K+ + W G + G+FP N+VK I
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFK 64
Query: 530 -----------------------IDIPEGGNGKRECVSS--HCVKGSRCVARFEYIGEQK 564
+P GG + K +C FEYI + +
Sbjct: 65 DDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNE 124
Query: 565 DELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE---DYPTSGANVLSTKVP 621
DEL G+II + E V E W G + + G+FP NFV+ +E D T A S V
Sbjct: 125 DELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVL 184
Query: 622 LKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS------DDLSFKRGDRIQILERLDSDW 675
+G S + SL A S T D+ FK G +++ R S
Sbjct: 185 -------AGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDI-FKEGS-VKLRTRTSSSE 235
Query: 676 CRGRLQDREGIFPAVFVRPCPAE-AKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDI 733
+ ++ I ++ + E K+ K ++ + L+ + G NEDEL+FK G+I
Sbjct: 236 TEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEI 295
Query: 734 I--TELESVDDDWMSGELMGKSGIFPKNY 760
I E+ + W GEL GK G+FP N+
Sbjct: 296 IHLISKETGEAGWWRGELNGKEGVFPDNF 324
Score = 68.2 bits (165), Expect = 3e-11
Identities = 43/161 (26%), Positives = 72/161 (44%), Gaps = 40/161 (24%)
Query: 647 HSFTAETSDDLSFKRGDRIQILERLDSD-WCRGRLQDREGIFPAVFVRPCPAEAKSMLAI 705
+ + A D+L+ + G+ I+ +++L + W G L R G+FP FV+ E +
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Query: 706 VP---------------------------------------KGRKAKALYDFRGENEDEL 726
+P K R+ K L+++ +NEDEL
Sbjct: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
Query: 727 SFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 767
K GDII E V++ W SG L K G+FP N+++ L+++
Sbjct: 128 ELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVT 168
Score = 50.8 bits (120), Expect = 5e-06
Identities = 26/57 (45%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Query: 553 CVARFEYIGEQKDELSFSEGEII--ILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 607
C F Y G +DEL+F EGEII I KE W RGE+ G+ G+FP NF + +
Sbjct: 274 CRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINE 330
Score = 34.7 bits (78), Expect = 0.34
Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Query: 489 DDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDI 532
D+L GEI++L+ K + W+RG + G+FP N+ I ++
Sbjct: 286 DELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINEL 331
Score = 30.4 bits (67), Expect = 6.5
Identities = 26/85 (30%), Positives = 30/85 (35%), Gaps = 13/85 (15%)
Query: 100 KPELPKK---PNPGLIR------SVNPEIPGRGPLAESSDSGKKVPTPAPR----PLLLK 146
KP P K P P LI S+ PE E S P P+ P
Sbjct: 340 KPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKAS 399
Query: 147 KSVSSENPTYPSAPLKPVTVPPRLA 171
+ S YP P KPV PP +A
Sbjct: 400 NLLRSSGTVYPKRPEKPVPPPPPIA 424
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 88.2 bits (217), Expect = 3e-17
Identities = 83/341 (24%), Positives = 132/341 (38%), Gaps = 71/341 (20%)
Query: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 534
P+ L+ + ++ DL G+I+ L K+D WY G G PA+Y++ I +P
Sbjct: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP- 255
Query: 535 GGNGKRECVSSHCVKGSRCVARFEY--IGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 592
H + + FE + KD L+F++ EI+ + V+E WA G +
Sbjct: 256 -----------HAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGD 304
Query: 593 RTGIFPLNFVEPVE--------DYP-TSGANVLSTKVPLKTKKEDSGSNSQVNSLPA--- 640
+ GIFPL +VE + D P + A+ + +P DSG+ + V P
Sbjct: 305 KIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP-----SDSGAVASVAPSPTLSS 359
Query: 641 --------------EWCEALHSFTA-----ETSDDLSFKRGDRIQ--ILERLDSDWCRGR 679
+ + HSFTA +S S + I +L R
Sbjct: 360 SGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAAR 419
Query: 680 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAK-----------------ALYDFRGEN 722
+ D + A + + A S VP+ ALY ++ +
Sbjct: 420 IGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQK 479
Query: 723 EDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYI 761
DEL G++ LE D W G + G SG+FP NY+
Sbjct: 480 SDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
Score = 73.2 bits (178), Expect = 9e-13
Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 17/126 (13%)
Query: 644 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF---VRPCPAEAK 700
+AL+S+ + DL F +GD I + ++D W G L +G PA + ++P P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAP- 258
Query: 701 SMLAIVPKGRKAKALYDFRGENEDE----LSFKAGDIITELESVDDDWMSGELMGKSGIF 756
P+G KALYDF +++D+ L+F +I+T L VD++W G L K GIF
Sbjct: 259 ------PQG---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIF 309
Query: 757 PKNYIQ 762
P Y++
Sbjct: 310 PLLYVE 315
Score = 57.0 bits (136), Expect = 6e-08
Identities = 92/436 (21%), Positives = 154/436 (35%), Gaps = 86/436 (19%)
Query: 317 VRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSA----TRRSNKKLPFNRSSSDMD 372
VR+ + RP G T P PP + P + P L+ S P S++
Sbjct: 115 VRLLDGIRQRPRAG-TSPGGSPPARPIPGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGS 173
Query: 373 LQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYS---------KYMRGDVLVMLK 423
LAT + ++ +P L P G LYS K+ +GD++V+ +
Sbjct: 174 TAGSLRELATSRTAPAAK-----NPCLLPY---GKALYSYEGKEPGDLKFNKGDIIVLRR 225
Query: 424 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDF 483
+ + + + G + S ++ I PL P+ P P L+DF
Sbjct: 226 KVDEQWYHGELHGTQGFLPASYIQCIQPL-------PHAP-----------PQGKALYDF 267
Query: 484 PAEQVDD----LNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV------KVIID-- 531
+ D L T EI+ +L ++D +W G ++IGIFP YV K +I+
Sbjct: 268 EMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMD 327
Query: 532 -------------IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILK 578
+P S + S V+ F+ + K +
Sbjct: 328 KPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSV 387
Query: 579 EYVNEEWARGE-----------------VRGRTG-IFPLNFVEPVEDYPTSGANVLSTKV 620
+ + + A R G + L+ P +D +S A T V
Sbjct: 388 THRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDV-SSSAGSTPTAV 446
Query: 621 PLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGR- 679
P LP AL+++ + SD+L +G+ ++LE+ W +G
Sbjct: 447 PRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGAS 506
Query: 680 -LQDREGIFPAVFVRP 694
G+FP +V P
Sbjct: 507 LRTGVSGVFPGNYVTP 522
Score = 53.9 bits (128), Expect = 5e-07
Identities = 28/69 (40%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 697 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 756
A A ++P G KALY + G+ +L F GDII VD+ W GEL G G
Sbjct: 187 APAAKNPCLLPYG---KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFL 243
Query: 757 PKNYIQFLQ 765
P +YIQ +Q
Sbjct: 244 PASYIQCIQ 252
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/63 (34%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQI-GIFPANYVKVIIDIPEG 535
+ L+ + ++ D+L L GE+ +LEK W++G + R + G+FP NYV + +P G
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
Query: 536 GNG 538
G G
Sbjct: 530 GAG 532
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 554 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 611
+A + Y ++ DEL +GE+ + E + W +G G +G+FP N+V PV P
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
Query: 612 GA 613
GA
Sbjct: 530 GA 531
Score = 38.9 bits (89), Expect = 0.018
Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 680 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGR-----KAKALYDFRGENEDELSFKAGDII 734
L + G F P SM AI P+ + + + + + ++E E+ K GDI+
Sbjct: 791 LHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIV 850
Query: 735 TELESVDDDWMSGELM--GKSGIFPKNYIQ 762
+ +D W G L G++G+FP ++++
Sbjct: 851 FVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 37.0 bits (84), Expect = 0.069
Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 18/102 (17%)
Query: 593 RTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE 652
+ G LNF P P S A + + LP E + S+ +
Sbjct: 794 KAGSLDLNFTSPSRQAPLSMAAI----------------RPEPKLLPRERYRVVVSYPPQ 837
Query: 653 TSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFV 692
+ ++ K GD + + ++ + W +G LQ R G+FP FV
Sbjct: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879
Score = 35.4 bits (80), Expect = 0.20
Identities = 16/47 (34%), Positives = 29/47 (61%), Gaps = 2/47 (4%)
Query: 559 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 603
Y + + E+ EG+I+ + + + W +G ++ GRTG+FP +FVE
Sbjct: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 35.0 bits (79), Expect = 0.26
Identities = 14/51 (27%), Positives = 31/51 (60%), Gaps = 2/51 (3%)
Query: 479 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 527
V+ +P + ++ L G+IV++ +K + WY+G + + G+FP ++V+
Sbjct: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 84.7 bits (208), Expect = 3e-16
Identities = 48/162 (29%), Positives = 84/162 (51%), Gaps = 15/162 (9%)
Query: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 541
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 825 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 882
Query: 542 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 599
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 883 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 942
Query: 600 NFVEPVE-----------DYPTSGANVLSTKVPLKTKKEDSG 630
+V+ ++ D P S + S + +E+SG
Sbjct: 943 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 624 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 683
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 808 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 860
Query: 684 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 738
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 861 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 920
Query: 739 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 765
VD++W G + G S GIFP Y+ ++
Sbjct: 921 QVDENWYEGRIPGTSRQGIFPITYVDVIK 949
Score = 69.7 bits (169), Expect = 1e-11
Identities = 38/140 (27%), Positives = 69/140 (49%), Gaps = 18/140 (12%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 873
Query: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 874 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 925
Query: 675 WCRGRL--QDREGIFPAVFV 692
W GR+ R+GIFP +V
Sbjct: 926 WYEGRIPGTSRQGIFPITYV 945
Score = 53.9 bits (128), Expect = 5e-07
Identities = 52/209 (24%), Positives = 84/209 (40%), Gaps = 17/209 (8%)
Query: 323 LPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATR--RSNKKLPFNRSSSDMDLQKKQSNL 380
L PV+ +P P++ P P + + + R ++ R + KK
Sbjct: 952 LVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLK 1011
Query: 381 ATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGR 440
+ + + S + D P +PG PL S + + +QTE + + GE GR
Sbjct: 1012 PSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEA----EQTERH----RGGEQAGR 1063
Query: 441 VHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVY 500
+ P + R P+ +Q A L+ + + D+L L G+IV
Sbjct: 1064 KAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQA-----LYSYIPQNDDELELRDGDIVD 1118
Query: 501 LLEKIDTDWYRGNCR--NQIGIFPANYVK 527
++EK D W+ G R Q G FP NYVK
Sbjct: 1119 VMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 8/117 (6%)
Query: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 838 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 892
Query: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI 529
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 893 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 948
Score = 43.9 bits (102), Expect = 6e-04
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 713 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 766
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 1096 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
Score = 35.4 bits (80), Expect = 0.20
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 1097 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 84.0 bits (206), Expect = 5e-16
Identities = 41/127 (32%), Positives = 73/127 (57%), Gaps = 4/127 (3%)
Query: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 541
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 803 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 860
Query: 542 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 599
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 861 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 920
Query: 600 NFVEPVE 606
+V+ ++
Sbjct: 921 TYVDVIK 927
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 624 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 683
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 786 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 838
Query: 684 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 738
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 839 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 898
Query: 739 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 765
VD++W G + G S GIFP Y+ ++
Sbjct: 899 QVDENWYEGRIPGTSRQGIFPITYVDVIK 927
Score = 70.1 bits (170), Expect = 7e-12
Identities = 50/207 (24%), Positives = 90/207 (43%), Gaps = 31/207 (14%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 851
Query: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 852 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 903
Query: 675 WCRGRL--QDREGIFPAVFV----RPC---PAEAKSMLAIVPKGRKAKALYDFRGENE-- 723
W GR+ R+GIFP +V RP P + + R A A F ++
Sbjct: 904 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLI 963
Query: 724 ----DELSFKAGDIITELESVDDDWMS 746
L + E+ +V +W+S
Sbjct: 964 TPAPSSLPHSRRALSPEMHAVTSEWIS 990
Score = 49.7 bits (117), Expect = 1e-05
Identities = 39/130 (30%), Positives = 57/130 (43%), Gaps = 15/130 (11%)
Query: 400 PPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSR 459
P +PG PL S + + +QTE + + GE GR + P + R
Sbjct: 1172 PEESRPGKPLGSAFPGSEA----EQTERH----RGGEQAGRKAARRGGSQQPQAQQRRVT 1223
Query: 460 PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQ 517
P+ +Q A L+ + + D+L L G+IV ++EK D W+ G R Q
Sbjct: 1224 PDRSQTSQDLFSYQA-----LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 1278
Query: 518 IGIFPANYVK 527
G FP NYVK
Sbjct: 1279 FGTFPGNYVK 1288
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 8/117 (6%)
Query: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 816 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 870
Query: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI 529
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 871 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 926
Score = 43.9 bits (102), Expect = 6e-04
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 713 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 766
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1292
Score = 35.4 bits (80), Expect = 0.20
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.133 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,158,868
Number of Sequences: 37866
Number of extensions: 2275058
Number of successful extensions: 17024
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 868
Number of HSP's that attempted gapping in prelim test: 10290
Number of HSP's gapped (non-prelim): 5290
length of query: 767
length of database: 18,247,518
effective HSP length: 110
effective length of query: 657
effective length of database: 14,082,258
effective search space: 9252043506
effective search space used: 9252043506
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.