Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 193083141
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
(790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 1606 0.0
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 1546 0.0
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 1452 0.0
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 125 2e-28
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 125 2e-28
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 125 2e-28
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 117 3e-26
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 117 3e-26
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 115 1e-25
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 115 1e-25
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 115 2e-25
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 110 5e-24
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 109 9e-24
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 108 1e-23
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 108 1e-23
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 107 3e-23
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 106 1e-22
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 106 1e-22
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 105 2e-22
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 101 2e-21
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 101 2e-21
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 100 5e-21
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 100 9e-21
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 100 9e-21
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 99 2e-20
gi|39930351 dynamin binding protein [Homo sapiens] 97 8e-20
gi|11321634 CD2-associated protein [Homo sapiens] 91 5e-18
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 88 3e-17
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 85 3e-16
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 84 5e-16
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 1606 bits (4159), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA
Sbjct: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
Query: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP
Sbjct: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
Query: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK
Sbjct: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
Query: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT
Sbjct: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
Query: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE
Sbjct: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
Query: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK
Sbjct: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
Query: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHG 420
KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHG
Sbjct: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHG 420
Query: 421 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 480
IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR
Sbjct: 421 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 480
Query: 481 SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ 540
SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ
Sbjct: 481 SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ 540
Query: 541 IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL 600
IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL
Sbjct: 541 IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL 600
Query: 601 KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS 660
KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS
Sbjct: 601 KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS 660
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
Query: 721 EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP 780
EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP
Sbjct: 721 EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP 780
Query: 781 KNYIQFLQIS 790
KNYIQFLQIS
Sbjct: 781 KNYIQFLQIS 790
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 1546 bits (4004), Expect = 0.0
Identities = 767/790 (97%), Positives = 767/790 (97%), Gaps = 23/790 (2%)
Query: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA
Sbjct: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
Query: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP
Sbjct: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
Query: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK
Sbjct: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
Query: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT
Sbjct: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
Query: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE
Sbjct: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
Query: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK
Sbjct: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
Query: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHG 420
KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYM
Sbjct: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYM------ 414
Query: 421 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 480
RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR
Sbjct: 415 -----------------RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 457
Query: 481 SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ 540
SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ
Sbjct: 458 SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ 517
Query: 541 IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL 600
IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL
Sbjct: 518 IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL 577
Query: 601 KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS 660
KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS
Sbjct: 578 KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS 637
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA
Sbjct: 638 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 697
Query: 721 EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP 780
EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP
Sbjct: 698 EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP 757
Query: 781 KNYIQFLQIS 790
KNYIQFLQIS
Sbjct: 758 KNYIQFLQIS 767
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 1452 bits (3758), Expect = 0.0
Identities = 730/790 (92%), Positives = 730/790 (92%), Gaps = 59/790 (7%)
Query: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA
Sbjct: 1 MNIMNTEQSQNSIVSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPA 60
Query: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP
Sbjct: 61 ANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPNPGLIRSVNPEIP 120
Query: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK
Sbjct: 121 GRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYK 180
Query: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKT 240
SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVL
Sbjct: 181 SLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLG-------- 232
Query: 241 EPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 300
LHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE
Sbjct: 233 ----------------------------LHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVE 264
Query: 301 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 360
RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK
Sbjct: 265 RTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNK 324
Query: 361 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHG 420
KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYM
Sbjct: 325 KLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYM------ 378
Query: 421 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 480
RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR
Sbjct: 379 -----------------RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 421
Query: 481 SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ 540
SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ
Sbjct: 422 SRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ 481
Query: 541 IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL 600
IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL
Sbjct: 482 IGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIIL 541
Query: 601 KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS 660
KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS
Sbjct: 542 KEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNS 601
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA
Sbjct: 602 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 661
Query: 721 EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP 780
EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP
Sbjct: 662 EAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFP 721
Query: 781 KNYIQFLQIS 790
KNYIQFLQIS
Sbjct: 722 KNYIQFLQIS 731
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 125 bits (314), Expect = 2e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 486 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 545
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 863 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 920
Query: 546 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 593
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 921 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 976
Query: 594 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 653
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 977 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1018
Query: 654 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 708
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 1019 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1078
Query: 709 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 767
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 1079 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1137
Query: 768 MSGELMGKSGIFPKNYIQ 785
GE+ G +G+FP NY++
Sbjct: 1138 WQGEINGVTGLFPSNYVK 1155
Score = 95.5 bits (236), Expect = 2e-19
Identities = 99/404 (24%), Positives = 171/404 (42%), Gaps = 57/404 (14%)
Query: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 789 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 848
Query: 389 SQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVS---QNPGELSCKRGDVLVML 445
F V P P H V + + + S + L+ + D++ +L
Sbjct: 849 KSAFTR--TVSPGSVSPIHG-----QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL 901
Query: 446 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV---- 501
+Q EN + G G S +KII P E R P A + A ++V
Sbjct: 902 EQQENWWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEY 959
Query: 502 -VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
L+ + + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+
Sbjct: 960 IALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGS 1017
Query: 561 GKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR---- 616
+ S+ K Y+ ++LS + G++I++ + W +GE++ R
Sbjct: 1018 ASKSGASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKR 1075
Query: 617 -TGIFPLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSF 672
G FP + V+ P + T + + + A++ +
Sbjct: 1076 QKGWFPASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDY 1111
Query: 673 TAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 716
A D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 1112 AANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1155
Score = 80.5 bits (197), Expect = 6e-15
Identities = 66/264 (25%), Positives = 124/264 (46%), Gaps = 32/264 (12%)
Query: 403 PKPGHPLYSKYMLSVPHGIANEDIV-----SQNPGELSCKRGDVLVMLKQTENNYLECQK 457
P+ + +K S + + E I S PG+L+ G+ +++ Q + +
Sbjct: 937 PEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEE-ILVTQKDGEWWTGSI 995
Query: 458 GEDTGRVHLSQMKIITPLD-EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNL 516
G+ +G + + P D E S + +KP + A V A + L+L
Sbjct: 996 GDRSG---IFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYV-----ASGSEQLSL 1047
Query: 517 TSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCV 571
G+++ +L+K + W++G + Q G FPA++VK++ G + +R + H V
Sbjct: 1048 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV 1102
Query: 572 KGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDY 631
+ +A ++Y +DELSFS+G++I + + +W +GE+ G TG+FP N+V+ D
Sbjct: 1103 --CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1160
Query: 632 PTS-----GANVLSTKVPLKTKKE 650
S L T P++ K++
Sbjct: 1161 DPSQQWCADLQTLDTMQPIERKRQ 1184
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 503 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 738 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 794
Query: 561 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 616
K ++ + V S E + + + VN W + R
Sbjct: 795 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 854
Query: 617 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 676
T + P V P+ G V +L A +AL S+TA+
Sbjct: 855 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 886
Query: 677 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 730
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 887 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 945
Query: 731 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 781
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 946 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1004
Query: 782 NYIQ 785
NY++
Sbjct: 1005 NYVK 1008
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 635
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 737 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 796
Query: 636 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 695
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 797 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 843
Query: 696 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 755
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 844 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 896
Query: 756 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 897 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 927
Score = 46.6 bits (109), Expect = 9e-05
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 736 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 785
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 787
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 598 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 656
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 655 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 714
Query: 657 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 703
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 715 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 774
Query: 704 QDREGIFPAVFVRPCPAEAKSMLAIVPK 731
Q G FP +V P+ +++ A+ PK
Sbjct: 775 QGNFGWFPCNYVEKMPS-SENEKAVSPK 801
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 125 bits (314), Expect = 2e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 486 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 545
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
Query: 546 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 593
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
Query: 594 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 653
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
Query: 654 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 708
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
Query: 709 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 767
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
Query: 768 MSGELMGKSGIFPKNYIQ 785
GE+ G +G+FP NY++
Sbjct: 1165 WQGEINGVTGLFPSNYVK 1182
Score = 95.5 bits (236), Expect = 2e-19
Identities = 99/404 (24%), Positives = 171/404 (42%), Gaps = 57/404 (14%)
Query: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
Query: 389 SQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVS---QNPGELSCKRGDVLVML 445
F V P P H V + + + S + L+ + D++ +L
Sbjct: 876 KSAFTR--TVSPGSVSPIHG-----QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL 928
Query: 446 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV---- 501
+Q EN + G G S +KII P E R P A + A ++V
Sbjct: 929 EQQENWWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEY 986
Query: 502 -VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
L+ + + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+
Sbjct: 987 IALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGS 1044
Query: 561 GKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR---- 616
+ S+ K Y+ ++LS + G++I++ + W +GE++ R
Sbjct: 1045 ASKSGASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKR 1102
Query: 617 -TGIFPLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSF 672
G FP + V+ P + T + + + A++ +
Sbjct: 1103 QKGWFPASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDY 1138
Query: 673 TAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 716
A D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 1139 AANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
Score = 80.5 bits (197), Expect = 6e-15
Identities = 66/264 (25%), Positives = 124/264 (46%), Gaps = 32/264 (12%)
Query: 403 PKPGHPLYSKYMLSVPHGIANEDIV-----SQNPGELSCKRGDVLVMLKQTENNYLECQK 457
P+ + +K S + + E I S PG+L+ G+ +++ Q + +
Sbjct: 964 PEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEE-ILVTQKDGEWWTGSI 1022
Query: 458 GEDTGRVHLSQMKIITPLD-EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNL 516
G+ +G + + P D E S + +KP + A V A + L+L
Sbjct: 1023 GDRSG---IFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYV-----ASGSEQLSL 1074
Query: 517 TSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCV 571
G+++ +L+K + W++G + Q G FPA++VK++ G + +R + H V
Sbjct: 1075 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV 1129
Query: 572 KGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDY 631
+ +A ++Y +DELSFS+G++I + + +W +GE+ G TG+FP N+V+ D
Sbjct: 1130 --CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1187
Query: 632 PTS-----GANVLSTKVPLKTKKE 650
S L T P++ K++
Sbjct: 1188 DPSQQWCADLQTLDTMQPIERKRQ 1211
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 503 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
Query: 561 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 616
K ++ + V S E + + + VN W + R
Sbjct: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
Query: 617 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 676
T + P V P+ G V +L A +AL S+TA+
Sbjct: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
Query: 677 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 730
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
Query: 731 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 781
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
Query: 782 NYIQ 785
NY++
Sbjct: 1032 NYVK 1035
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 635
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
Query: 636 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 695
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
Query: 696 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 755
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
Query: 756 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
Score = 46.6 bits (109), Expect = 9e-05
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 736 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 785
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 598 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 656
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
Query: 657 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 703
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
Query: 704 QDREGIFPAVFVRPCPAEAKSMLAIVPK 731
Q G FP +V P+ +++ A+ PK
Sbjct: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 125 bits (314), Expect = 2e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 486 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 545
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
Query: 546 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 593
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
Query: 594 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 653
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
Query: 654 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 708
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
Query: 709 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 767
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
Query: 768 MSGELMGKSGIFPKNYIQ 785
GE+ G +G+FP NY++
Sbjct: 1165 WQGEINGVTGLFPSNYVK 1182
Score = 95.5 bits (236), Expect = 2e-19
Identities = 99/404 (24%), Positives = 171/404 (42%), Gaps = 57/404 (14%)
Query: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
Query: 389 SQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVS---QNPGELSCKRGDVLVML 445
F V P P H V + + + S + L+ + D++ +L
Sbjct: 876 KSAFTR--TVSPGSVSPIHG-----QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL 928
Query: 446 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV---- 501
+Q EN + G G S +KII P E R P A + A ++V
Sbjct: 929 EQQENWWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEY 986
Query: 502 -VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
L+ + + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+
Sbjct: 987 IALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGS 1044
Query: 561 GKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR---- 616
+ S+ K Y+ ++LS + G++I++ + W +GE++ R
Sbjct: 1045 ASKSGASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKR 1102
Query: 617 -TGIFPLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSF 672
G FP + V+ P + T + + + A++ +
Sbjct: 1103 QKGWFPASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDY 1138
Query: 673 TAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 716
A D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 1139 AANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
Score = 80.5 bits (197), Expect = 6e-15
Identities = 66/264 (25%), Positives = 124/264 (46%), Gaps = 32/264 (12%)
Query: 403 PKPGHPLYSKYMLSVPHGIANEDIV-----SQNPGELSCKRGDVLVMLKQTENNYLECQK 457
P+ + +K S + + E I S PG+L+ G+ +++ Q + +
Sbjct: 964 PEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEE-ILVTQKDGEWWTGSI 1022
Query: 458 GEDTGRVHLSQMKIITPLD-EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNL 516
G+ +G + + P D E S + +KP + A V A + L+L
Sbjct: 1023 GDRSG---IFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYV-----ASGSEQLSL 1074
Query: 517 TSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCV 571
G+++ +L+K + W++G + Q G FPA++VK++ G + +R + H V
Sbjct: 1075 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV 1129
Query: 572 KGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDY 631
+ +A ++Y +DELSFS+G++I + + +W +GE+ G TG+FP N+V+ D
Sbjct: 1130 --CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1187
Query: 632 PTS-----GANVLSTKVPLKTKKE 650
S L T P++ K++
Sbjct: 1188 DPSQQWCADLQTLDTMQPIERKRQ 1211
Score = 73.6 bits (179), Expect = 7e-13
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 503 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
Query: 561 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 616
K ++ + V S E + + + VN W + R
Sbjct: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
Query: 617 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 676
T + P V P+ G V +L A +AL S+TA+
Sbjct: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
Query: 677 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 730
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
Query: 731 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 781
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
Query: 782 NYIQ 785
NY++
Sbjct: 1032 NYVK 1035
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 635
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
Query: 636 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 695
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
Query: 696 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 755
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
Query: 756 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
Score = 46.6 bits (109), Expect = 9e-05
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 736 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 785
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
Score = 40.0 bits (92), Expect = 0.008
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 598 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 656
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
Query: 657 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 703
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
Query: 704 QDREGIFPAVFVRPCPAEAKSMLAIVPK 731
Q G FP +V P+ +++ A+ PK
Sbjct: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 117 bits (294), Expect = 3e-26
Identities = 115/477 (24%), Positives = 196/477 (41%), Gaps = 73/477 (15%)
Query: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
+PGK + PPPLP T + + L S+ G+ G PPR
Sbjct: 395 EPGKSSILQHERPPPLP----------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR- 443
Query: 324 PPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQS 378
+G P+ + P + P RPP L + + + FN +SS D L++ S
Sbjct: 444 -----SGAPTPSSRAPA-LSPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMS 496
Query: 379 NLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKR 438
+ + K + K++ V PPR G+ ++ +PG +
Sbjct: 497 SASMASDFRKRR--KSEPAVGPPR-----------------GLGDQSASRTSPGRVDLPG 537
Query: 439 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVDSGA 497
+ T ++ + +D S +T + R R P + P
Sbjct: 538 SSTTLTKSFTSSSPSSPSRAKDRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP----- 591
Query: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 592 --AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PE 648
Query: 558 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG-- 615
R + + +A++ + + ELS +G+ +IL + V++ W G++ G
Sbjct: 649 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 708
Query: 616 RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSL 661
R GIFP+++VE V EDYP S + S + + N Q
Sbjct: 709 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 768
Query: 662 PAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
P +AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 769 P---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 822
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 545 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 604
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 563 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 620
Query: 605 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 664
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 621 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 663
Query: 665 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 720
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 664 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 723
Query: 721 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 748
K S+ + P+ G +ALY++ NEDE
Sbjct: 724 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 783
Query: 749 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 787
L + D+I +E DD W G G FP NY++ L
Sbjct: 784 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 590 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 646
Query: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 647 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 706
Query: 775 --KSGIFPKNYIQFLQ 788
+ GIFP +Y++ ++
Sbjct: 707 TNRQGIFPVSYVEVVK 722
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 117 bits (294), Expect = 3e-26
Identities = 115/477 (24%), Positives = 196/477 (41%), Gaps = 73/477 (15%)
Query: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
+PGK + PPPLP T + + L S+ G+ G PPR
Sbjct: 302 EPGKSSILQHERPPPLP----------TTPTPVPREPGRKPLSSSRLGEVTGSPSPPPR- 350
Query: 324 PPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQS 378
+G P+ + P + P RPP L + + + FN +SS D L++ S
Sbjct: 351 -----SGAPTPSSRAPA-LSPTRPPKKPLDYVQDHSSGV-FNEASLYQSSIDRSLERPMS 403
Query: 379 NLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKR 438
+ + K + K++ V PPR G+ ++ +PG +
Sbjct: 404 SASMASDFRKRR--KSEPAVGPPR-----------------GLGDQSASRTSPGRVDLPG 444
Query: 439 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVDSGA 497
+ T ++ + +D S +T + R R P + P
Sbjct: 445 SSTTLTKSFTSSSPSSPSRAKDRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP----- 498
Query: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 499 --AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PE 555
Query: 558 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG-- 615
R + + +A++ + + ELS +G+ +IL + V++ W G++ G
Sbjct: 556 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 615
Query: 616 RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSL 661
R GIFP+++VE V EDYP S + S + + N Q
Sbjct: 616 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 675
Query: 662 PAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
P +AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 676 P---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 729
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 545 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 604
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 470 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 527
Query: 605 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 664
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 528 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 570
Query: 665 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 720
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 571 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 630
Query: 721 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 748
K S+ + P+ G +ALY++ NEDE
Sbjct: 631 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 690
Query: 749 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 787
L + D+I +E DD W G G FP NY++ L
Sbjct: 691 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 497 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 553
Query: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 554 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 613
Query: 775 --KSGIFPKNYIQFLQ 788
+ GIFP +Y++ ++
Sbjct: 614 TNRQGIFPVSYVEVVK 629
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 115 bits (289), Expect = 1e-25
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 45/312 (14%)
Query: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII------ 553
A L+ + A++ + LN +++ +LE+ D W+ G + Q G FP +YVK+I
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 554 --------DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 605
+ P + V G +A + Y ++ +L+F +G++I++ + +
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-D 1035
Query: 606 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 665
+W G V + G+FP N+V ++D SG +G + P E
Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVR-LKDSEGSGT---------------AGKTGSLGKKP-EI 1078
Query: 666 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE-----GIFPAVFVRPC-P 719
+ + S+TA + L+ G I I ++ W G LQ R G FPA +V+ P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 720 AEAKSMLAIVPKGRKAKA------LYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 773
+K PK A +YD+ +N+DEL+F G II L D DW GE+
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 774 GKSGIFPKNYIQ 785
G+ G+FP NY++
Sbjct: 1199 GQVGLFPSNYVK 1210
Score = 83.6 bits (205), Expect = 7e-16
Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILK-EYVNEE------WARGEVRGRTGIFPLNFVE--PV 628
A + + DE++ G+I+++K E+V+E W GE++G+TG FP N+ E P
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPE 806
Query: 629 EDYP------TSGANVLSTKVPLK-TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLS 681
+ P T + + K+ L+ T + ++S+ ++ P W + ++ T++
Sbjct: 807 NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPE 866
Query: 682 FKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDF 741
D L G+L+ R PA P+ V +G +A+ALY +
Sbjct: 867 TDNWDAWAAQPSLTVP-SAGQLRQRSAFTPATATGSSPSPVLGQGEKV-EGLQAQALYPW 924
Query: 742 RGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
R + ++ L+F D+IT LE D W GE+ G+ G FPK+Y++ +
Sbjct: 925 RAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI 969
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 571 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 630
V+G + A + + ++ + L+F++ ++I + E + W GEV+G+ G FP ++V+ +
Sbjct: 913 VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISG 971
Query: 631 --YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRI 688
++ + S++ P K+ S + V S E A++++ + DL+F++GD I
Sbjct: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVS--GEEFIAMYTYESSEQGDLTFQQGDVI 1029
Query: 689 QILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML----AIVPKGRKAKALYDFRGE 744
+ ++ D DW G + D+ G+FP+ +VR +E ++ K A+ + +
Sbjct: 1030 LVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTAT 1088
Query: 745 NEDELSFKAGDIITELESVDDDWMSGELMGKS-----GIFPKNYIQFL 787
++L+ G +I + W GEL + G FP NY++ L
Sbjct: 1089 GPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 75.9 bits (185), Expect = 1e-13
Identities = 61/265 (23%), Positives = 121/265 (45%), Gaps = 25/265 (9%)
Query: 375 KKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGEL 434
+K +++ +G S++ + + + P P ++S IA S G+L
Sbjct: 974 RKSTSMDSGSSESPASLKRVASPAAKP------------VVSGEEFIAMYTYESSEQGDL 1021
Query: 435 SCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVD 494
+ ++GDV+++ K+ + ++ G+ G + +++ E + S +KP
Sbjct: 1022 TFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKD--SEGSGTAGKTGSLGKKP-- 1076
Query: 495 SGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYV 549
A V+ + A + L L G+++ + +K W+ G + QIG FPANYV
Sbjct: 1077 ---EIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV 1133
Query: 550 KVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWA 609
K++ S+ + + ++Y + DEL+F++G+II + + +W
Sbjct: 1134 KLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWW 1193
Query: 610 RGEVRGRTGIFPLNFVEPVEDYPTS 634
+GEV G+ G+FP N+V+ D S
Sbjct: 1194 KGEVNGQVGLFPSNYVKLTTDMDPS 1218
Score = 64.3 bits (155), Expect = 4e-10
Identities = 73/318 (22%), Positives = 126/318 (39%), Gaps = 53/318 (16%)
Query: 504 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNG 561
HD Q D+ + GE V + + W G + + G FPANY + I ++P
Sbjct: 756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKP 815
Query: 562 KRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWA--------RGEV 613
+ S+ K + + E L+ + E WA
Sbjct: 816 VTDSTSAPAPKLA--------LRETPAPLAVTSSE----PSTTPNNWADFSSTWPTSTNE 863
Query: 614 RGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGS-----NSQVNSLPAEWCEA 668
+ T + +P P++G + T S S +V L A+ A
Sbjct: 864 KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQ---A 920
Query: 669 LHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR------------ 716
L+ + A+ + L+F + D I +LE+ D W G +Q ++G FP +V+
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKSTSM 979
Query: 717 -----PCPAEAKSMLAIVPK----GRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 767
PA K + + K G + A+Y + + +L+F+ GD+I + D DW
Sbjct: 980 DSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVIL-VTKKDGDW 1038
Query: 768 MSGELMGKSGIFPKNYIQ 785
+G + K+G+FP NY++
Sbjct: 1039 WTGTVGDKAGVFPSNYVR 1056
Score = 46.6 bits (109), Expect = 9e-05
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 701 GRL--QDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA---KALYDFRGENEDELSFKAGD 755
GRL Q +E PAV AE + + K +ALY F + DE++ + GD
Sbjct: 706 GRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGD 765
Query: 756 IIT-------ELESVDDDWMSGELMGKSGIFPKNYIQ 785
I+ E ++ + W+ GEL GK+G FP NY +
Sbjct: 766 IVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 115 bits (289), Expect = 1e-25
Identities = 85/312 (27%), Positives = 142/312 (45%), Gaps = 45/312 (14%)
Query: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII------ 553
A L+ + A++ + LN +++ +LE+ D W+ G + Q G FP +YVK+I
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 554 --------DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 605
+ P + V G +A + Y ++ +L+F +G++I++ + +
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-D 1035
Query: 606 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 665
+W G V + G+FP N+V ++D SG +G + P E
Sbjct: 1036 GDWWTGTVGDKAGVFPSNYVR-LKDSEGSGT---------------AGKTGSLGKKP-EI 1078
Query: 666 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE-----GIFPAVFVRPC-P 719
+ + S+TA + L+ G I I ++ W G LQ R G FPA +V+ P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 720 AEAKSMLAIVPKGRKAKA------LYDFRGENEDELSFKAGDIITELESVDDDWMSGELM 773
+K PK A +YD+ +N+DEL+F G II L D DW GE+
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 774 GKSGIFPKNYIQ 785
G+ G+FP NY++
Sbjct: 1199 GQVGLFPSNYVK 1210
Score = 83.6 bits (205), Expect = 7e-16
Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 19/226 (8%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILK-EYVNEE------WARGEVRGRTGIFPLNFVE--PV 628
A + + DE++ G+I+++K E+V+E W GE++G+TG FP N+ E P
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPE 806
Query: 629 EDYP------TSGANVLSTKVPLK-TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLS 681
+ P T + + K+ L+ T + ++S+ ++ P W + ++ T++
Sbjct: 807 NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPE 866
Query: 682 FKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDF 741
D L G+L+ R PA P+ V +G +A+ALY +
Sbjct: 867 TDNWDAWAAQPSLTVP-SAGQLRQRSAFTPATATGSSPSPVLGQGEKV-EGLQAQALYPW 924
Query: 742 RGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
R + ++ L+F D+IT LE D W GE+ G+ G FPK+Y++ +
Sbjct: 925 RAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI 969
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/228 (24%), Positives = 113/228 (49%), Gaps = 15/228 (6%)
Query: 571 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 630
V+G + A + + ++ + L+F++ ++I + E + W GEV+G+ G FP ++V+ +
Sbjct: 913 VEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLISG 971
Query: 631 --YPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRI 688
++ + S++ P K+ S + V S E A++++ + DL+F++GD I
Sbjct: 972 PIRKSTSMDSGSSESPASLKRVASPAAKPVVS--GEEFIAMYTYESSEQGDLTFQQGDVI 1029
Query: 689 QILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSML----AIVPKGRKAKALYDFRGE 744
+ ++ D DW G + D+ G+FP+ +VR +E ++ K A+ + +
Sbjct: 1030 LVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASYTAT 1088
Query: 745 NEDELSFKAGDIITELESVDDDWMSGELMGKS-----GIFPKNYIQFL 787
++L+ G +I + W GEL + G FP NY++ L
Sbjct: 1089 GPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 75.9 bits (185), Expect = 1e-13
Identities = 61/265 (23%), Positives = 121/265 (45%), Gaps = 25/265 (9%)
Query: 375 KKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGEL 434
+K +++ +G S++ + + + P P ++S IA S G+L
Sbjct: 974 RKSTSMDSGSSESPASLKRVASPAAKP------------VVSGEEFIAMYTYESSEQGDL 1021
Query: 435 SCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVD 494
+ ++GDV+++ K+ + ++ G+ G + +++ E + S +KP
Sbjct: 1022 TFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKD--SEGSGTAGKTGSLGKKP-- 1076
Query: 495 SGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYV 549
A V+ + A + L L G+++ + +K W+ G + QIG FPANYV
Sbjct: 1077 ---EIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYV 1133
Query: 550 KVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWA 609
K++ S+ + + ++Y + DEL+F++G+II + + +W
Sbjct: 1134 KLLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWW 1193
Query: 610 RGEVRGRTGIFPLNFVEPVEDYPTS 634
+GEV G+ G+FP N+V+ D S
Sbjct: 1194 KGEVNGQVGLFPSNYVKLTTDMDPS 1218
Score = 64.3 bits (155), Expect = 4e-10
Identities = 73/318 (22%), Positives = 126/318 (39%), Gaps = 53/318 (16%)
Query: 504 HDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNG 561
HD Q D+ + GE V + + W G + + G FPANY + I ++P
Sbjct: 756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKP 815
Query: 562 KRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWA--------RGEV 613
+ S+ K + + E L+ + E WA
Sbjct: 816 VTDSTSAPAPKLA--------LRETPAPLAVTSSE----PSTTPNNWADFSSTWPTSTNE 863
Query: 614 RGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGS-----NSQVNSLPAEWCEA 668
+ T + +P P++G + T S S +V L A+ A
Sbjct: 864 KPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQ---A 920
Query: 669 LHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR------------ 716
L+ + A+ + L+F + D I +LE+ D W G +Q ++G FP +V+
Sbjct: 921 LYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIRKSTSM 979
Query: 717 -----PCPAEAKSMLAIVPK----GRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 767
PA K + + K G + A+Y + + +L+F+ GD+I + D DW
Sbjct: 980 DSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVIL-VTKKDGDW 1038
Query: 768 MSGELMGKSGIFPKNYIQ 785
+G + K+G+FP NY++
Sbjct: 1039 WTGTVGDKAGVFPSNYVR 1056
Score = 46.6 bits (109), Expect = 9e-05
Identities = 32/97 (32%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 701 GRL--QDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA---KALYDFRGENEDELSFKAGD 755
GRL Q +E PAV AE + + K +ALY F + DE++ + GD
Sbjct: 706 GRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGD 765
Query: 756 IIT-------ELESVDDDWMSGELMGKSGIFPKNYIQ 785
I+ E ++ + W+ GEL GK+G FP NY +
Sbjct: 766 IVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 115 bits (288), Expect = 2e-25
Identities = 159/746 (21%), Positives = 280/746 (37%), Gaps = 130/746 (17%)
Query: 49 SSGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPN 108
S+ +P V P + GT G P P + + P+T P L
Sbjct: 121 SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP 180
Query: 109 PGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAP--LKPVTV 166
P L R + P R SG P P S S P P AP L+ V+
Sbjct: 181 PHLQRWPHHSQPARA-------SGSFAPISQTPP-----SFSPPPPLVPPAPEDLRRVSE 228
Query: 167 PPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPT---PSGNLAEE 223
P S + L E V LI D P+ PS
Sbjct: 229 PDLTGAVSSTDSSPLLNE----------------VSSSLIGTDSQAFPSVSKPSSAYPST 272
Query: 224 SVGSEMVL-------DPFQLPAKTEPIKERAV---QPAPTRKPTVIRIPAKPGKCLHEDP 273
++ + ++ +L + ++P+ ER V APT++ P PGK + +
Sbjct: 273 TIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEK-----PTSPGKAIEKRA 327
Query: 274 QSPPPLPAEK--------------PIGNT------FSTVSGKLSNVERTRNLESNHPGQT 313
+ + P+ NT + T+ ++ + R + + P +
Sbjct: 328 KDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYS 387
Query: 314 GGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDL 373
P PR + + + K P P + S+ + S+++ + +D
Sbjct: 388 FSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDT 447
Query: 374 QKKQSNLAT--GLSKAKSQVFKNQ--DPVLPPRPK-----PGHPLYSKYMLSVPHGIANE 424
+K ++ + KS V N+ + P P+ PG+ S + H + E
Sbjct: 448 RKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNF-----HAVKRE 502
Query: 425 DIVSQNPGELSCKRGDVLVMLKQTENNYLECQ--------------KGEDTGRVHLSQMK 470
PG+L+ + + E + Q K ++ R H
Sbjct: 503 S--DGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPR-HFIPAD 559
Query: 471 IITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDT 530
+ +E +R R +D +P A DF A+ + +L L G+IVY+ ++ID
Sbjct: 560 YLESTEEFIRRRHDDKE--MRP-------ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQ 610
Query: 531 DWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDEL 590
+WY G ++GIFP Y++++ P ++ ++ +A+F + G+ + E+
Sbjct: 611 NWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEM 668
Query: 591 SFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPVE-----------DYPTSG-- 635
SF +GE I L V+E W G + G R GIFP+ +V+ ++ D P S
Sbjct: 669 SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP 728
Query: 636 --ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILER 693
+ S + P ++ + SQ + + +AL+S+ + D+L + GD + ++E+
Sbjct: 729 SRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK 787
Query: 694 LDSDWCRG--RLQDREGIFPAVFVRP 717
D W G R + G FP +V+P
Sbjct: 788 CDDGWFVGTSRRTKQFGTFPGNYVKP 813
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 582 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPP------- 634
Query: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 635 ---------AEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 685
Query: 698 WCRGRLQ--DREGIFPAVFV----RPC---------------PAEAKSMLAIVPKGRKAK 736
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 686 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 745
Query: 737 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 778
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 746 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 805
Query: 779 FPKNYIQFLQI 789
FP NY++ L +
Sbjct: 806 FPGNYVKPLYL 816
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/55 (40%), Positives = 34/55 (61%)
Query: 733 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
R A+A +DF+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 578 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 632
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 110 bits (275), Expect = 5e-24
Identities = 133/620 (21%), Positives = 248/620 (40%), Gaps = 106/620 (17%)
Query: 176 AKAYKSLGEGPPANPPVPVLQSKPL---VDIDLISFDDDVLPT---PSGNLAEESVGSEM 229
AK Y+S+ P++ S PL V LI D P+ PS ++ +
Sbjct: 90 AKGYRSVHPNLPSDKSQ---DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPT 146
Query: 230 VL-------DPFQLPAKTEPIKERAV---QPAPTRKPTVIRIPAKPGKCLHEDPQSPPPL 279
++ +L + ++P+ ER V APT++ P PGK + + +
Sbjct: 147 IVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEK-----PTSPGKAIEKRAKDDSRR 201
Query: 280 PAEK--------------PIGNT------FSTVSGKLSNVERTRNLESNHPGQTGGFVRV 319
+ P+ NT + T+ ++ + R + + P +
Sbjct: 202 VVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTK 261
Query: 320 PPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSN 379
P PR + + + K P P + S+ + S+++ + +D +K ++
Sbjct: 262 SPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 321
Query: 380 LAT--GLSKAKSQVFKNQ--DPVLPPRPK-----PGHPLYSKYMLSVPHGIANEDIVSQN 430
+ KS V N+ + P P+ PG+ S + H + E
Sbjct: 322 PKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNF-----HAVKRES--DGA 374
Query: 431 PGELSCKRGDVLVMLKQTENNYLECQ--------------KGEDTGRVHLSQMKIITPLD 476
PG+L+ + + E + Q K ++ R H + +
Sbjct: 375 PGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPR-HFIPADYLESTE 433
Query: 477 EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 536
E +R R +D +P A DF A+ + +L L G+IVY+ ++ID +WY G
Sbjct: 434 EFIRRRHDDKE--MRP-------ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 484
Query: 537 CRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGE 596
++GIFP Y++++ P ++ ++ +A+F + G+ + E+SF +GE
Sbjct: 485 HHGRVGIFPRTYIELL--PPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGE 542
Query: 597 IIILKEYVNEEWARGEVRG--RTGIFPLNFVEPVE-----------DYPTSG----ANVL 639
I L V+E W G + G R GIFP+ +V+ ++ D P S +
Sbjct: 543 RITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATA 602
Query: 640 STKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWC 699
S + P ++ + SQ + + +AL+S+ + D+L + GD + ++E+ D W
Sbjct: 603 SPQQPQAQQRRVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEKCDDGWF 661
Query: 700 RG--RLQDREGIFPAVFVRP 717
G R + G FP +V+P
Sbjct: 662 VGTSRRTKQFGTFPGNYVKP 681
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 450 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPP------- 502
Query: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 503 ---------AEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 553
Query: 698 WCRGRLQ--DREGIFPAVFV----RPC---------------PAEAKSMLAIVPKGRKAK 736
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 554 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 613
Query: 737 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 778
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 614 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 673
Query: 779 FPKNYIQFLQI 789
FP NY++ L +
Sbjct: 674 FPGNYVKPLYL 684
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/55 (40%), Positives = 34/55 (61%)
Query: 733 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
R A+A +DF+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 446 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 500
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 109 bits (273), Expect = 9e-24
Identities = 114/480 (23%), Positives = 198/480 (41%), Gaps = 68/480 (14%)
Query: 273 PQSPPPLPAEKPIGNTFSTVSGKLSNVER---TRNLESN-------HPGQTGGFVRVPP- 321
P PPP+P +P + ST +R TR S PG++ P
Sbjct: 217 PHVPPPVPPLRPRDRS-STEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPT 275
Query: 322 -RLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQK 375
R+ P ++ + P + +++ RPPP K + + FN +SS D L++
Sbjct: 276 DRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLER 335
Query: 376 KQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELS 435
S+ + K + K++ V PPR G+ ++ +PG +
Sbjct: 336 PMSSASMASDFRKRR--KSEPAVGPPR-----------------GLGDQSASRTSPGRVD 376
Query: 436 CKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVD 494
+ T ++ + +D S +T + R R P + P
Sbjct: 377 LPGSSTTLTKSFTSSSPSSPSRAKDRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP-- 433
Query: 495 SGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIID 554
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ +
Sbjct: 434 -----AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 488
Query: 555 IPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR 614
PE R + + +A++ + + ELS +G+ +IL + V++ W G++
Sbjct: 489 -PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 547
Query: 615 G--RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQV 658
G R GIFP+++VE V EDYP S + S + + N Q
Sbjct: 548 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQG 607
Query: 659 NSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
P +AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 608 GGEP---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 664
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 545 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 604
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 405 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 462
Query: 605 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 664
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 463 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 505
Query: 665 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 720
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 506 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 565
Query: 721 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 748
K S+ + P+ G +ALY++ NEDE
Sbjct: 566 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 625
Query: 749 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 787
L + D+I +E DD W G G FP NY++ L
Sbjct: 626 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 432 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 488
Query: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 489 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 548
Query: 775 --KSGIFPKNYIQFLQ 788
+ GIFP +Y++ ++
Sbjct: 549 TNRQGIFPVSYVEVVK 564
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 108 bits (271), Expect = 1e-23
Identities = 99/417 (23%), Positives = 173/417 (41%), Gaps = 52/417 (12%)
Query: 338 PPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT--GLSKAKSQVFKNQ 395
PP VPP P PP R S +K ++ +D +K +S + KS + +++
Sbjct: 88 PPPHVPP--PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHE 145
Query: 396 DPVLP---------PRPKPGHPLYSKYM--------LSVPHGIANEDIVSQNPGELSCKR 438
P RP + S + + P G+ ++ +PG +
Sbjct: 146 RPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPG 205
Query: 439 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVDSGA 497
+ T ++ + +D S +T + R R P + P
Sbjct: 206 SSTTLTKSFTSSSPSSPSRAKDRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP----- 259
Query: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 260 --AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PE 316
Query: 558 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG-- 615
R + + +A++ + + ELS +G+ +IL + V++ W G++ G
Sbjct: 317 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 376
Query: 616 RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSL 661
R GIFP+++VE V EDYP S + S + + N Q
Sbjct: 377 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 436
Query: 662 PAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
P +AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 437 P---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 545 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 604
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 231 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 288
Query: 605 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 664
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 289 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 331
Query: 665 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 720
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 332 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 391
Query: 721 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 748
K S+ + P+ G +ALY++ NEDE
Sbjct: 392 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 451
Query: 749 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 787
L + D+I +E DD W G G FP NY++ L
Sbjct: 452 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 258 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314
Query: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 315 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 374
Query: 775 --KSGIFPKNYIQFLQ 788
+ GIFP +Y++ ++
Sbjct: 375 TNRQGIFPVSYVEVVK 390
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 108 bits (271), Expect = 1e-23
Identities = 99/417 (23%), Positives = 173/417 (41%), Gaps = 52/417 (12%)
Query: 338 PPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT--GLSKAKSQVFKNQ 395
PP VPP P PP R S +K ++ +D +K +S + KS + +++
Sbjct: 240 PPPHVPP--PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHE 297
Query: 396 DPVLP---------PRPKPGHPLYSKYM--------LSVPHGIANEDIVSQNPGELSCKR 438
P RP + S + + P G+ ++ +PG +
Sbjct: 298 RPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPG 357
Query: 439 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVDSGA 497
+ T ++ + +D S +T + R R P + P
Sbjct: 358 SSTTLTKSFTSSSPSSPSRAKDRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP----- 411
Query: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 412 --AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PE 468
Query: 558 GGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG-- 615
R + + +A++ + + ELS +G+ +IL + V++ W G++ G
Sbjct: 469 KAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTN 528
Query: 616 RTGIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSL 661
R GIFP+++VE V EDYP S + S + + N Q
Sbjct: 529 RQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 588
Query: 662 PAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
P +AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 589 P---FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 642
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 545 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 604
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 383 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 440
Query: 605 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 664
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 441 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 483
Query: 665 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 720
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 484 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 543
Query: 721 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 748
K S+ + P+ G +ALY++ NEDE
Sbjct: 544 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 603
Query: 749 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 787
L + D+I +E DD W G G FP NY++ L
Sbjct: 604 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 410 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
Query: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 467 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 526
Query: 775 --KSGIFPKNYIQFLQ 788
+ GIFP +Y++ ++
Sbjct: 527 TNRQGIFPVSYVEVVK 542
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 107 bits (268), Expect = 3e-23
Identities = 97/396 (24%), Positives = 167/396 (42%), Gaps = 55/396 (13%)
Query: 345 ERPPPPKLSATRRSNKKLPFN-----RSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVL 399
ERPPP K + + FN +SS D L++ S+ + K + K++ V
Sbjct: 295 ERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRR--KSEPAVG 352
Query: 400 PPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGE 459
PPR G+ ++ +PG + + T ++ + +
Sbjct: 353 PPR-----------------GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK 395
Query: 460 DTGRVHLSQMKIITPLDEHL-RSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTS 518
D S +T + R R P + P A ++DF A+ +L+
Sbjct: 396 DRESPR-SYSSTLTDMGRSAPRERRGTPEKEKLP-------AKAVYDFKAQTSKELSFKK 447
Query: 519 GEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVA 578
G+ VY+L KID +WY G ++GIFP +YV+ + PE R + + +A
Sbjct: 448 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKAQPARPPPPAQPGEIGEAIA 506
Query: 579 RFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPV-------E 629
++ + + ELS +G+ +IL + V++ W G++ G R GIFP+++VE V E
Sbjct: 507 KYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAE 566
Query: 630 DYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 682
DYP S + S + + N Q P +AL+++T D+L
Sbjct: 567 DYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP---FQALYNYTPRNEDELEL 623
Query: 683 KRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
+ D I ++E+ D W G + + G FP +V+
Sbjct: 624 RESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 659
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 545 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 604
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 400 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 457
Query: 605 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 664
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 458 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 500
Query: 665 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 720
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 501 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 560
Query: 721 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 748
K S+ + P+ G +ALY++ NEDE
Sbjct: 561 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 620
Query: 749 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 787
L + D+I +E DD W G G FP NY++ L
Sbjct: 621 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 427 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483
Query: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 484 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 543
Query: 775 --KSGIFPKNYIQFLQ 788
+ GIFP +Y++ ++
Sbjct: 544 TNRQGIFPVSYVEVVK 559
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 106 bits (264), Expect = 1e-22
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 564
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 509 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 566
Query: 565 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 622
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 567 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 626
Query: 623 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 667
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 627 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 685
Query: 668 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 717
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 686 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 737
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 557
Query: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 558 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 609
Query: 698 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 736
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 610 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 669
Query: 737 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 778
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 670 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 729
Query: 779 FPKNYIQFLQI 789
FP NY++ L +
Sbjct: 730 FPGNYVKPLYL 740
Score = 70.1 bits (170), Expect = 8e-12
Identities = 63/239 (26%), Positives = 106/239 (44%), Gaps = 38/239 (15%)
Query: 422 ANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRS 481
A D +Q EL ++GD++ + KQ + N+ E GE GRV + I L ++
Sbjct: 506 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKA 562
Query: 482 RPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RN 539
+P + Q ++ G A+ +F + +++ GE + LL ++D +WY G +
Sbjct: 563 QPKKLTPVQV-LEYG--EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 619
Query: 540 QIGIFPANYVKVI-----------IDIPEGGNGKRECVSS--------HCVKGSRC---- 576
+ GIFP YV VI +D+P + R +S V R
Sbjct: 620 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 679
Query: 577 -----VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 680 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 15/167 (8%)
Query: 630 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQ 689
D P G + L + K+ S S + +PA++ E+ F DD D+ +
Sbjct: 396 DIPLQGLSGLKRPSSSASTKD---SESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 452
Query: 690 IL-ERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRK--------AKALYD 740
+ E+ ++D R G+ P +L I ++ A+A +D
Sbjct: 453 LKREQEEADIAARR---HTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 509
Query: 741 FRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
F+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 510 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 556
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 106 bits (264), Expect = 1e-22
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 564
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 550 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 607
Query: 565 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 622
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 608 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 667
Query: 623 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 667
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 668 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 726
Query: 668 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 717
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 727 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 778
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 598
Query: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 599 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 650
Query: 698 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 736
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 651 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 710
Query: 737 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 778
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 711 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 770
Query: 779 FPKNYIQFLQI 789
FP NY++ L +
Sbjct: 771 FPGNYVKPLYL 781
Score = 70.1 bits (170), Expect = 8e-12
Identities = 63/239 (26%), Positives = 106/239 (44%), Gaps = 38/239 (15%)
Query: 422 ANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRS 481
A D +Q EL ++GD++ + KQ + N+ E GE GRV + I L ++
Sbjct: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKA 603
Query: 482 RPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RN 539
+P + Q ++ G A+ +F + +++ GE + LL ++D +WY G +
Sbjct: 604 QPKKLTPVQV-LEYG--EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 660
Query: 540 QIGIFPANYVKVI-----------IDIPEGGNGKRECVSS--------HCVKGSRC---- 576
+ GIFP YV VI +D+P + R +S V R
Sbjct: 661 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 720
Query: 577 -----VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 721 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 15/167 (8%)
Query: 630 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQ 689
D P G + L + K+ S S + +PA++ E+ F DD D+ +
Sbjct: 437 DIPLQGLSGLKRPSSSASTKD---SESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 493
Query: 690 IL-ERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRK--------AKALYD 740
+ E+ ++D R G+ P +L I ++ A+A +D
Sbjct: 494 LKREQEEADIAARR---HTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 550
Query: 741 FRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
F+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 551 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 597
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 105 bits (261), Expect = 2e-22
Identities = 80/327 (24%), Positives = 140/327 (42%), Gaps = 43/327 (13%)
Query: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV---------- 549
A+V D+ A+ D+L ++ GEI+ + K D W+ G + G+FP N+V
Sbjct: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
Query: 550 --------KVIIDIPEGGNGKRECVSSHCV---------KGSRCVARFEYIGEQKDELSF 592
K + ++P G + +SS + + RC F Y+ + DEL
Sbjct: 64 PLTNKAPEKPLHEVPSGNS----LLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELEL 119
Query: 593 SEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDS 652
G+II + V E W G + G+TG+FP NF++ + ++ + +E +
Sbjct: 120 KVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETT 179
Query: 653 GSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPA 712
GS S + E + A + +G + + R R + E F
Sbjct: 180 GSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLP 239
Query: 713 V---------FVRPCPAEAKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDIITEL-- 760
V P +K+ + K + K ++ + +N+DEL+ K GDI+T +
Sbjct: 240 VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINK 299
Query: 761 ESVDDDWMSGELMGKSGIFPKNYIQFL 787
+ +D W GEL G+ G+FP N+++ L
Sbjct: 300 DCIDVGWWEGELNGRRGVFPDNFVKLL 326
Score = 67.0 bits (162), Expect = 6e-11
Identities = 68/340 (20%), Positives = 137/340 (40%), Gaps = 54/340 (15%)
Query: 421 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 480
I D +Q+ EL+ G+++ +++ + + E G+ GR L + + + ++
Sbjct: 5 IVEFDYQAQHDDELTISVGEIITNIRKEDGGWWE---GQINGRRGLFPDNFVREIKKEMK 61
Query: 481 SRPNDPSHAQKP---VDSGAP-------------------HAVVLHDFPAEQVDDLNLTS 518
P +KP V SG V + + D+L L
Sbjct: 62 KDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKV 121
Query: 519 GEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII-DIPEGGNGKRECVSSHCVKGSRCV 577
G+I+ ++ +++ W+ G + G+FP+N++K + + E G + E +S ++
Sbjct: 122 GDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLR----- 176
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR----TGIFPLNFVEPVEDYPT 633
E G + D S + E N A ++ + G + +P++ P
Sbjct: 177 ---ETTGSESDGGDSSSTK----SEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPR 229
Query: 634 S---------GANVLSTKVPLKTKKEDSGSNSQVNSLPA-EWCEALHSFTAETSDDLSFK 683
S + K+P T DS + + ++C+ + + A+ D+L+ K
Sbjct: 230 SIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIK 289
Query: 684 RGDRIQILER--LDSDWCRGRLQDREGIFPAVFVRPCPAE 721
GD + ++ + +D W G L R G+FP FV+ P +
Sbjct: 290 EGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPD 329
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/107 (30%), Positives = 52/107 (48%), Gaps = 7/107 (6%)
Query: 576 CVARFEYIGEQKDELSFSEGEIIIL--KEYVNEEWARGEVRGRTGIFPLNFVEPV-EDYP 632
C F Y + DEL+ EG+I+ L K+ ++ W GE+ GR G+FP NFV+ + D+
Sbjct: 272 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFE 331
Query: 633 TSGANVLSTKVP-LKTKKEDSGSNS---QVNSLPAEWCEALHSFTAE 675
G P K+ +G+ ++ +P E E L + T E
Sbjct: 332 KEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEE 378
Score = 43.9 bits (102), Expect = 6e-04
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 6/81 (7%)
Query: 486 PSHAQKPVDS---GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEK--IDTDWYRGNCRNQ 540
P ++ +DS + V+ + A+ D+L + G+IV L+ K ID W+ G +
Sbjct: 255 PDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR 314
Query: 541 IGIFPANYVKVI-IDIPEGGN 560
G+FP N+VK++ D + GN
Sbjct: 315 RGVFPDNFVKLLPPDFEKEGN 335
Score = 34.3 bits (77), Expect = 0.46
Identities = 47/179 (26%), Positives = 67/179 (37%), Gaps = 23/179 (12%)
Query: 236 LPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGK 295
LP E R +P P P VI+ A + HE + PP P P + +
Sbjct: 326 LPPDFEKEGNRPKKPPPPSAP-VIKQGAGTTERKHEIKKIPPERPEMLP------NRTEE 378
Query: 296 LSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPP--KLS 353
ER L+ P +PP+ P P KT +P +PP RP P L+
Sbjct: 379 KERPEREPKLDLQKPSVPA----IPPKKPRPP---KTNSLSRPGA-LPPRRPERPVGPLT 430
Query: 354 ATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSK 412
TR + K+ SS L K S+ + + + D V+ K HP S+
Sbjct: 431 HTRGDSPKIDLAGSSLSGILDKDLSDRSNDID------LEGFDSVVSSTEKLSHPTTSR 483
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 559
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 772 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 830
Query: 560 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 617
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 831 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 890
Query: 618 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 663
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 891 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 949
Query: 664 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 950 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1002
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 545 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 604
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 743 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 800
Query: 605 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 664
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 801 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 843
Query: 665 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 720
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 844 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 903
Query: 721 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 748
K S+ + P+ G +ALY++ NEDE
Sbjct: 904 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 963
Query: 749 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 787
L + D+I +E DD W G G FP NY++ L
Sbjct: 964 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 770 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826
Query: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 827 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 886
Query: 775 --KSGIFPKNYIQFLQ 788
+ GIFP +Y++ ++
Sbjct: 887 TNRQGIFPVSYVEVVK 902
Score = 81.6 bits (200), Expect = 3e-15
Identities = 68/256 (26%), Positives = 112/256 (43%), Gaps = 41/256 (16%)
Query: 401 PRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGED 460
PR + G P K + D +Q ELS K+GD + +L++ + N+ E GE
Sbjct: 758 PRERRGTPEKEKLPAKAVY-----DFKAQTSKELSFKKGDTVYILRKIDQNWYE---GEH 809
Query: 461 TGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGE 520
GRV + + + L +++P P +P + G A+ ++F A+ +L+L G+
Sbjct: 810 HGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIG--EAIAKYNFNADTNVELSLRKGD 867
Query: 521 IVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRC-- 576
V LL+++D +WY G N+ GIFP +YV+V+ +G + H R
Sbjct: 868 RVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHS 927
Query: 577 -----------------------VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV 613
A + Y +DEL E ++I + E ++ W G
Sbjct: 928 LSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 987
Query: 614 RGRT---GIFPLNFVE 626
R RT G FP N+V+
Sbjct: 988 R-RTKFFGTFPGNYVK 1002
Score = 59.3 bits (142), Expect = 1e-08
Identities = 50/250 (20%), Positives = 100/250 (40%), Gaps = 30/250 (12%)
Query: 330 GKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKS 389
G++ P ++ T + P +++K+L F + + L+K N G +
Sbjct: 754 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 813
Query: 390 QVFKNQ--DPVLPP-RPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLK 446
+F + + PP + +P P + IA + + ELS ++GD +++LK
Sbjct: 814 GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 873
Query: 447 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR------------------------SR 482
+ + N+ E K T R + + + + ++ + ++
Sbjct: 874 RVDQNWYE-GKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 932
Query: 483 PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ-- 540
P P + + G L+++ D+L L +++ ++EK D W+ G R
Sbjct: 933 PQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 992
Query: 541 IGIFPANYVK 550
G FP NYVK
Sbjct: 993 FGTFPGNYVK 1002
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/96 (38%), Positives = 50/96 (52%), Gaps = 15/96 (15%)
Query: 701 GRLQDREGIFPAVFV-------RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSF 751
G LQDRE P + R P E + P+ K AKA+YDF+ + ELSF
Sbjct: 735 GALQDRES--PRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSF 788
Query: 752 KAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
K GD + L +D +W GE G+ GIFP +Y++ L
Sbjct: 789 KKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 824
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 101 bits (252), Expect = 2e-21
Identities = 67/235 (28%), Positives = 114/235 (48%), Gaps = 22/235 (9%)
Query: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGG 559
A ++DF A+ +L+ G+ VY+L KID +WY G ++GIFP +YV+ + PE
Sbjct: 868 AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP-PEKA 926
Query: 560 NGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RT 617
R + + +A++ + + ELS +G+ +IL + V++ W G++ G R
Sbjct: 927 QPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQ 986
Query: 618 GIFPLNFVEPV-------EDYPT-------SGANVLSTKVPLKTKKEDSGSNSQVNSLPA 663
GIFP+++VE V EDYP S + S + + N Q P
Sbjct: 987 GIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEP- 1045
Query: 664 EWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDRE--GIFPAVFVR 716
+AL+++T D+L + D I ++E+ D W G + + G FP +V+
Sbjct: 1046 --FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 1098
Score = 98.6 bits (244), Expect = 2e-20
Identities = 74/281 (26%), Positives = 125/281 (44%), Gaps = 57/281 (20%)
Query: 545 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 604
P +Y + D+ G + RE + + A +++ + ELSF +G+ + + +
Sbjct: 839 PRSYSSTLTDM--GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKI 896
Query: 605 NEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAE 664
++ W GE GR GIFP+++VE + P A P + P E
Sbjct: 897 DQNWYEGEHHGRVGIFPISYVEKLT--PPEKAQPARPPPPAQ---------------PGE 939
Query: 665 WCEAL--HSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFVRPCPA 720
EA+ ++F A+T+ +LS ++GDR+ +L+R+D +W G++ +R+GIFP +V
Sbjct: 940 IGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKK 999
Query: 721 EAK--------------------SMLAIVPK------------GRKAKALYDFRGENEDE 748
K S+ + P+ G +ALY++ NEDE
Sbjct: 1000 NTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDE 1059
Query: 749 LSFKAGDIITELESVDDDWMSGELMGKS--GIFPKNYIQFL 787
L + D+I +E DD W G G FP NY++ L
Sbjct: 1060 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 84.3 bits (207), Expect = 4e-16
Identities = 48/136 (35%), Positives = 75/136 (55%), Gaps = 11/136 (8%)
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA 720
LPA+ A++ F A+TS +LSFK+GD + IL ++D +W G R GIFP +V
Sbjct: 866 LPAK---AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922
Query: 721 EAKSMLAIVPKGR------KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMG 774
K+ A P +A A Y+F + ELS + GD + L+ VD +W G++ G
Sbjct: 923 PEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPG 982
Query: 775 --KSGIFPKNYIQFLQ 788
+ GIFP +Y++ ++
Sbjct: 983 TNRQGIFPVSYVEVVK 998
Score = 81.6 bits (200), Expect = 3e-15
Identities = 68/256 (26%), Positives = 112/256 (43%), Gaps = 41/256 (16%)
Query: 401 PRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGED 460
PR + G P K + D +Q ELS K+GD + +L++ + N+ E GE
Sbjct: 854 PRERRGTPEKEKLPAKAVY-----DFKAQTSKELSFKKGDTVYILRKIDQNWYE---GEH 905
Query: 461 TGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGE 520
GRV + + + L +++P P +P + G A+ ++F A+ +L+L G+
Sbjct: 906 HGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIG--EAIAKYNFNADTNVELSLRKGD 963
Query: 521 IVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRC-- 576
V LL+++D +WY G N+ GIFP +YV+V+ +G + H R
Sbjct: 964 RVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHS 1023
Query: 577 -----------------------VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV 613
A + Y +DEL E ++I + E ++ W G
Sbjct: 1024 LSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTS 1083
Query: 614 RGRT---GIFPLNFVE 626
R RT G FP N+V+
Sbjct: 1084 R-RTKFFGTFPGNYVK 1098
Score = 59.3 bits (142), Expect = 1e-08
Identities = 50/250 (20%), Positives = 100/250 (40%), Gaps = 30/250 (12%)
Query: 330 GKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKS 389
G++ P ++ T + P +++K+L F + + L+K N G +
Sbjct: 850 GRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRV 909
Query: 390 QVFKNQ--DPVLPP-RPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGDVLVMLK 446
+F + + PP + +P P + IA + + ELS ++GD +++LK
Sbjct: 910 GIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLK 969
Query: 447 QTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR------------------------SR 482
+ + N+ E K T R + + + + ++ + ++
Sbjct: 970 RVDQNWYE-GKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNK 1028
Query: 483 PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQ-- 540
P P + + G L+++ D+L L +++ ++EK D W+ G R
Sbjct: 1029 PQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 1088
Query: 541 IGIFPANYVK 550
G FP NYVK
Sbjct: 1089 FGTFPGNYVK 1098
Score = 58.9 bits (141), Expect = 2e-08
Identities = 37/96 (38%), Positives = 50/96 (52%), Gaps = 15/96 (15%)
Query: 701 GRLQDREGIFPAVFV-------RPCPAEAKSMLAIVPKGRK--AKALYDFRGENEDELSF 751
G LQDRE P + R P E + P+ K AKA+YDF+ + ELSF
Sbjct: 831 GALQDRES--PRSYSSTLTDMGRSAPRERRG----TPEKEKLPAKAVYDFKAQTSKELSF 884
Query: 752 KAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
K GD + L +D +W GE G+ GIFP +Y++ L
Sbjct: 885 KKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 920
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 100 bits (249), Expect = 5e-21
Identities = 93/351 (26%), Positives = 148/351 (42%), Gaps = 39/351 (11%)
Query: 453 LECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVD 512
L K D G L + + P S N + + A + DF A+
Sbjct: 338 LSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPK 397
Query: 513 DLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNGKRECVSSHC 570
+L L G+IVY+ +++D +W G ++GIFPANYV+V+ +IP+ + +
Sbjct: 398 ELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK----PIKPPTYQV 453
Query: 571 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFV--- 625
++ VA++ + G+ + ELSF +GE I L VNE W G + GR GIFP ++V
Sbjct: 454 LEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS 513
Query: 626 -EP----VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDL 680
EP +D P + T + S S + + P + L T+
Sbjct: 514 REPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID----LGGQTSPRRTGF 569
Query: 681 SFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA----- 735
SF + R + Q+ PA+ P+ + P +
Sbjct: 570 SFPTQEP------------RPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPY 617
Query: 736 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYI 784
+A+Y +R +NEDEL + GD + ++ DD W G K G FP NY+
Sbjct: 618 RAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Score = 77.8 bits (190), Expect = 4e-14
Identities = 106/471 (22%), Positives = 180/471 (38%), Gaps = 71/471 (15%)
Query: 264 KPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRL 323
+P K L +DP P P E + + +S +L R + RL
Sbjct: 254 RPKKPLVDDPGEKPSQPIEVLLERELAELSAELDKDLRA----------------IETRL 297
Query: 324 PPRPVNGKTIPTQQP-PTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT 382
P P P P + P +RPP SA S P+ S+ + K
Sbjct: 298 PS--------PKSSPAPRRAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHK------- 342
Query: 383 GLSKAKSQVFKNQDPVLPPRPKP-------GHPLYSKYMLSVPHGIANEDIVSQNPGELS 435
++ S +D V P + G P + + D +Q+P EL+
Sbjct: 343 -MADGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARL-KFDFQAQSPKELT 400
Query: 436 CKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDS 495
++GD++ + K+ + N+LE GE GR+ + + L +P P Q ++
Sbjct: 401 LQKGDIVYIHKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQ-VLEY 456
Query: 496 GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVII 553
G AV + F + +L+ GE + L+ K++ +WY G + GIFPA+YV+V
Sbjct: 457 G--EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQV-- 512
Query: 554 DIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV 613
RE C G + + S L+ + G+
Sbjct: 513 --------SREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRSPADPIDLGGQT 562
Query: 614 RGRTGIFPLNFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWC--EA 668
R F EP ++ T G + ++ P + D G++S N+ W A
Sbjct: 563 SPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-NTSQIHWTPYRA 619
Query: 669 LHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 717
++ + + D+L + GDR+ ++++ D W G R + G FP +V P
Sbjct: 620 MYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAP 670
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 672 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 726
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 391 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 450
Query: 727 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 784
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 451 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 510
Query: 785 Q 785
Q
Sbjct: 511 Q 511
Score = 52.4 bits (124), Expect = 2e-06
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 731 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 381 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 437
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 99.8 bits (247), Expect = 9e-21
Identities = 70/241 (29%), Positives = 107/241 (44%), Gaps = 25/241 (10%)
Query: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDT-DWYRGNCRNQIGIFPANYVKVIIDIPEGG 559
+VL + A++ D+L+L G++V + + W RG + G+FP V+ +IPE
Sbjct: 4 LVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQ---EIPETL 60
Query: 560 NGKRECVSSHCVKGSR-----------CVARFEYIGEQKDELSFSEGEIIILKEYVNEEW 608
G E C + C F Y EQ DEL GEI+ + + + + W
Sbjct: 61 RGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGW 120
Query: 609 ARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP------ 662
G+ G+ G FP NFVE ++ P S N V ++ S+ +S P
Sbjct: 121 WLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
Query: 663 --AEWCEALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRLQDREGIFPAVFVRPC 718
E L + E D+L+ +RGD +++L + D W G Q R G+FP FV P
Sbjct: 181 SHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPP 240
Query: 719 P 719
P
Sbjct: 241 P 241
Score = 88.2 bits (217), Expect = 3e-17
Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 38/235 (16%)
Query: 582 YIGEQKDELSFSEGEIIILKEYVNEE-WARGEVRGRTGIFPLNFVEPVEDYPTSGANVLS 640
Y +++DELS + G+++ +V W RGE GR G+FP V+ + +
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 641 TKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCR 700
+ + + + P WC+ S++ E +D+L + G+ +++++ ++ W
Sbjct: 69 PRCARRR------GHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWL 122
Query: 701 GRLQDREGIFPAVFVR------------------PCPAEAKSM-----------LAIVPK 731
G+ + G FP+ FV P P + L V
Sbjct: 123 GKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSH 182
Query: 732 GRKAKALYDFRGENEDELSFKAGDIITELESVDDD--WMSGELMGKSGIFPKNYI 784
+ L+D++ E DEL+ + GD++ L +D W GE G+ G+FP N++
Sbjct: 183 PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237
Score = 60.8 bits (146), Expect = 5e-09
Identities = 37/135 (27%), Positives = 63/135 (46%), Gaps = 16/135 (11%)
Query: 669 LHSFTAETSDDLSFKRGDRIQILERLDS-DWCRGRLQDREGIFPAVFVRPCP------AE 721
L + A+ D+LS GD ++ + + + W RG R G+FP V+ P E
Sbjct: 6 LAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGE 65
Query: 722 AKSMLAIVPKGRKAK---------ALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL 772
A+ +G AK + + E DEL +AG+I+ ++ ++D W G+
Sbjct: 66 ARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKK 125
Query: 773 MGKSGIFPKNYIQFL 787
G+ G FP N+++ L
Sbjct: 126 NGQLGAFPSNFVELL 140
Score = 35.0 bits (79), Expect = 0.27
Identities = 56/233 (24%), Positives = 93/233 (39%), Gaps = 38/233 (16%)
Query: 135 VPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPV 194
+P P + L+ +K VS E SAP+K P +L + K L P
Sbjct: 238 LPPPPIKKLVPRKVVSRE-----SAPIKE---PKKLMPKTSLPTVKKLATAT-TGPSKAK 288
Query: 195 LQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQP---- 250
P D ++ D P+G +S GS P + +KT+ ++R+V
Sbjct: 289 TSRTPSRDSQKLTSRDS---GPNGGF--QSGGS---YHPGRKRSKTQTPQQRSVSSQEEE 340
Query: 251 --APTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNL--E 306
+P + P+V R P E P +P P+ K I K+ + E+T L +
Sbjct: 341 HSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKI-----PAPDKVPSPEKTLTLGDK 395
Query: 307 SNHPG-QTGGFVRVPPRLPP-----RPVNGKTIPTQQ--PPTKVPPERPPPPK 351
++ PG T G + P ++P P + +IP P + ++P P+
Sbjct: 396 ASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPE 448
Score = 33.9 bits (76), Expect = 0.60
Identities = 71/362 (19%), Positives = 108/362 (29%), Gaps = 68/362 (18%)
Query: 29 SGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRASGE---WDSGTENRLKVTSKEGLT 85
+ LP ++ + P +S PS + +R SG + SG + T
Sbjct: 269 TSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQT 328
Query: 86 PYP----PLQEAGSIPVTKPELPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPR 141
P +E S PV P + + P P ++ PE P P E++ S KK+P P
Sbjct: 329 PQQRSVSSQEEEHSSPVKAPSVKRTPMPD--KTATPERP---PAPENAPSSKKIPAPDKV 383
Query: 142 PLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLV 201
P K + + P G P P
Sbjct: 384 PSPEKTLTLGDKASIP-------------------------GNSTSGKIPAP-------- 410
Query: 202 DIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQPAPTRKPTVIRI 261
D +PTP + E D +P + +E P+ V +
Sbjct: 411 ---------DKVPTPEKMVTPE--------DKASIPENSIIPEETLTVDKPSTPERVFSV 453
Query: 262 PAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPP 321
P L P P P P+G+ T+ L+ + + Q F
Sbjct: 454 EESP--ALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEA 511
Query: 322 RLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLA 381
+ K P+ Q P PP P S K R D +Q+ L
Sbjct: 512 LQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRG----DSSPRQAELK 567
Query: 382 TG 383
+G
Sbjct: 568 SG 569
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 99.8 bits (247), Expect = 9e-21
Identities = 91/344 (26%), Positives = 146/344 (42%), Gaps = 39/344 (11%)
Query: 460 DTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSG 519
D G L + + P S N + + A + DF A+ +L L G
Sbjct: 3 DGGSPFLGRRDFVYPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKG 62
Query: 520 EIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVI--IDIPEGGNGKRECVSSHCVKGSRCV 577
+IVY+ +++D +W G ++GIFPANYV+V+ +IP+ + + ++ V
Sbjct: 63 DIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK----PIKPPTYQVLEYGEAV 118
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFV----EP---- 627
A++ + G+ + ELSF +GE I L VNE W G + GR GIFP ++V EP
Sbjct: 119 AQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRL 178
Query: 628 VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDR 687
+D P + T + S S + + P + L T+ SF +
Sbjct: 179 CDDGPQLPTSPRLTAAARSARHPSSPSALRSPADPID----LGGQTSPRRTGFSFPTQEP 234
Query: 688 IQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKA-----KALYDFR 742
R + Q+ PA+ P+ + P + +A+Y +R
Sbjct: 235 ------------RPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYR 282
Query: 743 GENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYI 784
+NEDEL + GD + ++ DD W G K G FP NY+
Sbjct: 283 PQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
Score = 75.1 bits (183), Expect = 2e-13
Identities = 42/121 (34%), Positives = 68/121 (56%), Gaps = 7/121 (5%)
Query: 672 FTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAE-----AKSML 726
F A++ +L+ ++GD + I + +D +W G R GIFPA +V PA+ K
Sbjct: 49 FQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPT 108
Query: 727 AIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL--MGKSGIFPKNYI 784
V + +A A Y F+G+ E ELSF+ G+ I + V+++W G + G+ GIFP +Y+
Sbjct: 109 YQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYV 168
Query: 785 Q 785
Q
Sbjct: 169 Q 169
Score = 72.4 bits (176), Expect = 2e-12
Identities = 73/302 (24%), Positives = 129/302 (42%), Gaps = 30/302 (9%)
Query: 425 DIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPN 484
D +Q+P EL+ ++GD++ + K+ + N+LE GE GR+ + + L +P
Sbjct: 48 DFQAQSPKELTLQKGDIVYIHKEVDKNWLE---GEHHGRLGIFPANYVEVLPADEIPKPI 104
Query: 485 DPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIG 542
P Q ++ G AV + F + +L+ GE + L+ K++ +WY G + G
Sbjct: 105 KPPTYQ-VLEYG--EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQG 161
Query: 543 IFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKE 602
IFPA+YV+V RE C G + + S L+
Sbjct: 162 IFPASYVQV----------SREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPS--ALRS 209
Query: 603 YVNEEWARGEVRGRTGIFPLNFVEP---VEDYPTSGANVLSTKVPLKTKKEDSGSNSQVN 659
+ G+ R F EP ++ T G + ++ P + D G++S N
Sbjct: 210 PADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGP--SHPLDLGTSSP-N 266
Query: 660 SLPAEWC--EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFV 715
+ W A++ + + D+L + GDR+ ++++ D W G R + G FP +V
Sbjct: 267 TSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
Query: 716 RP 717
P
Sbjct: 327 AP 328
Score = 52.4 bits (124), Expect = 2e-06
Identities = 22/57 (38%), Positives = 37/57 (64%)
Query: 731 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
K + A+ +DF+ ++ EL+ + GDI+ + VD +W+ GE G+ GIFP NY++ L
Sbjct: 39 KRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVL 95
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
A ++Y + +DEL EG+ + + + ++ W G R + G FP N+V PV
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 99.0 bits (245), Expect = 2e-20
Identities = 68/251 (27%), Positives = 115/251 (45%), Gaps = 40/251 (15%)
Query: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 564
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 654 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 711
Query: 565 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 622
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 712 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 771
Query: 623 NFVEPVE-----------DYPTSGANVLSTKV------------PLKTKKEDSGSNSQV- 658
+V+ ++ D P S + S P T+ E S Q
Sbjct: 772 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQ 831
Query: 659 ----------NSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDR 706
S +AL+S+ + D+L + GD + ++E+ D W G R +
Sbjct: 832 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 891
Query: 707 EGIFPAVFVRP 717
G FP +V+P
Sbjct: 892 FGTFPGNYVKP 902
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 647 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 706
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 637 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 689
Query: 707 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 761
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 690 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 749
Query: 762 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 788
VD++W G + G S GIFP Y+ ++
Sbjct: 750 QVDENWYEGRIPGTSRQGIFPITYVDVIK 778
Score = 73.6 bits (179), Expect = 7e-13
Identities = 62/271 (22%), Positives = 108/271 (39%), Gaps = 75/271 (27%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 651 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 702
Query: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 703 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 754
Query: 698 WCRGRL--QDREGIFPAVFV----RPC------------------PAEAKSMLA------ 727
W GR+ R+GIFP +V RP A A L+
Sbjct: 755 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRA 814
Query: 728 -----------IVPKGRKAKALYDFRGENED----------------ELSFKAGDIITEL 760
+ P+ ++ + D ++D EL + GDI+ +
Sbjct: 815 GPDLTESEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 874
Query: 761 ESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 789
E DD W G + G FP NY++ L +
Sbjct: 875 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 905
Score = 64.7 bits (156), Expect = 3e-10
Identities = 62/259 (23%), Positives = 108/259 (41%), Gaps = 58/259 (22%)
Query: 422 ANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRS 481
A D +Q EL ++GD++ + KQ + N+ E GE GRV + I L ++
Sbjct: 651 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKA 707
Query: 482 RPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RN 539
+P + Q ++ G A+ +F + +++ GE + LL ++D +WY G +
Sbjct: 708 QPKKLTPVQV-LEYG--EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 764
Query: 540 QIGIFPANYVKVI-----------IDIPEGGNGKRECVSS-----HCVKGSRCV------ 577
+ GIFP YV VI +D+P + R +S H ++ +
Sbjct: 765 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKS 824
Query: 578 --------------------------ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARG 611
A + YI + DEL +G+I+ + E ++ W G
Sbjct: 825 YVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVG 884
Query: 612 EVR--GRTGIFPLNFVEPV 628
R + G FP N+V+P+
Sbjct: 885 TSRRTKQFGTFPGNYVKPL 903
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 96.7 bits (239), Expect = 8e-20
Identities = 85/317 (26%), Positives = 146/317 (46%), Gaps = 30/317 (9%)
Query: 433 ELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKP 492
EL GD++ +L + +L +K + TG+ S ++I+T PS
Sbjct: 20 ELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI-----------PS----- 63
Query: 493 VDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQIGIFPANYVKV 551
+ G V + +F ++++D+L L G++V L W +G +C G FP++ V+
Sbjct: 64 LKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRE 123
Query: 552 IIDIPEGGNGKRECVSSHCVKGSRCVAR--FEYIGEQKDELSFSEGEIIILKEYVNEEWA 609
+ + + + S AR + +EL F EG++I + W
Sbjct: 124 LCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWF 183
Query: 610 RGEVRGRTGIFPLNFVE------PVEDYPTSGAN---VLSTKVPLKTKKEDSGSNSQVNS 660
GE+ GR GIFP FVE V++ +SG +++ +V +E+ G +
Sbjct: 184 EGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEE 243
Query: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCP- 719
P + AL+ F A ++L F+ GD+I+IL L+ W G L+ R GIFP FV+ CP
Sbjct: 244 -PGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPD 302
Query: 720 AEAKSMLAIVPKGRKAK 736
+ +A+ +G A+
Sbjct: 303 TRVEETMALPQEGSLAR 319
Score = 94.7 bits (234), Expect = 3e-19
Identities = 82/316 (25%), Positives = 134/316 (42%), Gaps = 60/316 (18%)
Query: 503 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGK 562
+ DF ++L L G+I+ +L +D W G + G FP+++V+ I+ IP G+
Sbjct: 10 IFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVE-IVTIPSLKEGE 68
Query: 563 RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARG-EVRGRTGIFP 621
R V C+ E+ ++ D L G+++IL W +G G G FP
Sbjct: 69 RLFV---------CIC--EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFP 117
Query: 622 LNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP---AEWCEALHSFTAETSD 678
+ V ++ L ++ S S + +P AL +A+ +
Sbjct: 118 SSCVR---------------ELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDE 162
Query: 679 DLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR---PCPAEAKSMLA-------- 727
+L F+ GD I I+ + W G L+ R GIFP FV P +S+ +
Sbjct: 163 ELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIV 222
Query: 728 ------------IVP------KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMS 769
I P G ALY F+ +EL F+ GD I L +++D W+
Sbjct: 223 NGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLE 282
Query: 770 GELMGKSGIFPKNYIQ 785
G L G++GIFP +++
Sbjct: 283 GSLKGRTGIFPYRFVK 298
Score = 73.2 bits (178), Expect = 9e-13
Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 36/225 (16%)
Query: 573 GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 632
GS A F++ +EL G+II + V+E W G+ TG FP +FVE V
Sbjct: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT--- 60
Query: 633 TSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILE 692
+P S + L CE FT++ D+L RGD + +
Sbjct: 61 ----------IP---------SLKEGERLFVCICE----FTSQELDNLPLHRGDLVILDG 97
Query: 693 RLDSDWCRGR-LQDREGIFPAVFVRP-CPAE------AKSMLAIVPKGR--KAKALYDFR 742
+ W +GR G FP+ VR C + ++S L +P+ +A+AL
Sbjct: 98 IPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLS 157
Query: 743 GENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
+ ++EL F+ GD+IT + + W GEL G+ GIFP+ +++ L
Sbjct: 158 AQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELL 202
Score = 40.4 bits (93), Expect = 0.006
Identities = 19/58 (32%), Positives = 32/58 (55%)
Query: 732 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQI 789
G +A++DF +EL GDII L VD+ W+ G+ +G FP ++++ + I
Sbjct: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI 61
Score = 38.1 bits (87), Expect = 0.032
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Query: 720 AEAKSMLAIVPKGRKAK------ALYDFRGENEDELSFKAGDIITELESVD----DDWMS 769
A+A + P G +A+ A+Y F+ N +ELS A + LE D +W
Sbjct: 1497 AQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWL 1556
Query: 770 GELMGKSGIFPKNYIQ 785
E+ GK G P NYI+
Sbjct: 1557 AEVNGKKGYVPSNYIR 1572
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 90.5 bits (223), Expect = 5e-18
Identities = 90/329 (27%), Positives = 139/329 (42%), Gaps = 55/329 (16%)
Query: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTD-WYRGNCRNQIGIFPANYVKVI------- 552
+V +D+ A D+L + GEI+ ++K+ + W G + G+FP N+VK I
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFK 64
Query: 553 -----------------------IDIPEGGNGKRECVSS--HCVKGSRCVARFEYIGEQK 587
+P GG + K +C FEYI + +
Sbjct: 65 DDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNE 124
Query: 588 DELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVE---DYPTSGANVLSTKVP 644
DEL G+II + E V E W G + + G+FP NFV+ +E D T A S V
Sbjct: 125 DELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVL 184
Query: 645 LKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS------DDLSFKRGDRIQILERLDSDW 698
+G S + SL A S T D+ FK G +++ R S
Sbjct: 185 -------AGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDI-FKEGS-VKLRTRTSSSE 235
Query: 699 CRGRLQDREGIFPAVFVRPCPAE-AKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDI 756
+ ++ I ++ + E K+ K ++ + L+ + G NEDEL+FK G+I
Sbjct: 236 TEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEI 295
Query: 757 I--TELESVDDDWMSGELMGKSGIFPKNY 783
I E+ + W GEL GK G+FP N+
Sbjct: 296 IHLISKETGEAGWWRGELNGKEGVFPDNF 324
Score = 68.2 bits (165), Expect = 3e-11
Identities = 43/161 (26%), Positives = 72/161 (44%), Gaps = 40/161 (24%)
Query: 670 HSFTAETSDDLSFKRGDRIQILERLDSD-WCRGRLQDREGIFPAVFVRPCPAEAKSMLAI 728
+ + A D+L+ + G+ I+ +++L + W G L R G+FP FV+ E +
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67
Query: 729 VP---------------------------------------KGRKAKALYDFRGENEDEL 749
+P K R+ K L+++ +NEDEL
Sbjct: 68 LPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDEL 127
Query: 750 SFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQIS 790
K GDII E V++ W SG L K G+FP N+++ L+++
Sbjct: 128 ELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVT 168
Score = 50.8 bits (120), Expect = 5e-06
Identities = 26/57 (45%), Positives = 33/57 (57%), Gaps = 2/57 (3%)
Query: 576 CVARFEYIGEQKDELSFSEGEII--ILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 630
C F Y G +DEL+F EGEII I KE W RGE+ G+ G+FP NF + +
Sbjct: 274 CRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINE 330
Score = 34.7 bits (78), Expect = 0.35
Identities = 15/46 (32%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Query: 512 DDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDI 555
D+L GEI++L+ K + W+RG + G+FP N+ I ++
Sbjct: 286 DELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINEL 331
Score = 30.4 bits (67), Expect = 6.7
Identities = 26/85 (30%), Positives = 30/85 (35%), Gaps = 13/85 (15%)
Query: 100 KPELPKK---PNPGLIR------SVNPEIPGRGPLAESSDSGKKVPTPAPR----PLLLK 146
KP P K P P LI S+ PE E S P P+ P
Sbjct: 340 KPPPPAKAPAPKPELIAAEKKYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKAS 399
Query: 147 KSVSSENPTYPSAPLKPVTVPPRLA 171
+ S YP P KPV PP +A
Sbjct: 400 NLLRSSGTVYPKRPEKPVPPPPPIA 424
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 88.2 bits (217), Expect = 3e-17
Identities = 83/341 (24%), Positives = 132/341 (38%), Gaps = 71/341 (20%)
Query: 498 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPE 557
P+ L+ + ++ DL G+I+ L K+D WY G G PA+Y++ I +P
Sbjct: 197 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLP- 255
Query: 558 GGNGKRECVSSHCVKGSRCVARFEY--IGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 615
H + + FE + KD L+F++ EI+ + V+E WA G +
Sbjct: 256 -----------HAPPQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGD 304
Query: 616 RTGIFPLNFVEPVE--------DYP-TSGANVLSTKVPLKTKKEDSGSNSQVNSLPA--- 663
+ GIFPL +VE + D P + A+ + +P DSG+ + V P
Sbjct: 305 KIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLP-----SDSGAVASVAPSPTLSS 359
Query: 664 --------------EWCEALHSFTA-----ETSDDLSFKRGDRIQ--ILERLDSDWCRGR 702
+ + HSFTA +S S + I +L R
Sbjct: 360 SGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAAR 419
Query: 703 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAK-----------------ALYDFRGEN 745
+ D + A + + A S VP+ ALY ++ +
Sbjct: 420 IGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQK 479
Query: 746 EDELSFKAGDIITELESVDDDWMSGELM--GKSGIFPKNYI 784
DEL G++ LE D W G + G SG+FP NY+
Sbjct: 480 SDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
Score = 73.2 bits (178), Expect = 9e-13
Identities = 43/126 (34%), Positives = 67/126 (53%), Gaps = 17/126 (13%)
Query: 667 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVF---VRPCPAEAK 723
+AL+S+ + DL F +GD I + ++D W G L +G PA + ++P P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAP- 258
Query: 724 SMLAIVPKGRKAKALYDFRGENEDE----LSFKAGDIITELESVDDDWMSGELMGKSGIF 779
P+G KALYDF +++D+ L+F +I+T L VD++W G L K GIF
Sbjct: 259 ------PQG---KALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGMLGDKIGIF 309
Query: 780 PKNYIQ 785
P Y++
Sbjct: 310 PLLYVE 315
Score = 63.5 bits (153), Expect = 7e-10
Identities = 72/346 (20%), Positives = 126/346 (36%), Gaps = 64/346 (18%)
Query: 417 VPHGIANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLD 476
+P+G A + PG+L +GD++V+ ++ + + + G + S ++ I PL
Sbjct: 196 LPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPL- 254
Query: 477 EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDD----LNLTSGEIVYLLEKIDTDW 532
P+ P P L+DF + D L T EI+ +L ++D +W
Sbjct: 255 ------PHAP-----------PQGKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENW 297
Query: 533 YRGNCRNQIGIFPANYV------KVIID---------------IPEGGNGKRECVSSHCV 571
G ++IGIFP YV K +I+ +P S +
Sbjct: 298 AEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTL 357
Query: 572 KGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGE-----------------VR 614
S V+ F+ + K + + + + A
Sbjct: 358 SSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAA 417
Query: 615 GRTG-IFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFT 673
R G + L+ P +D +S A T VP LP AL+++
Sbjct: 418 ARIGDLAHLSCAAPTQDV-SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYK 476
Query: 674 AETSDDLSFKRGDRIQILERLDSDWCRGR--LQDREGIFPAVFVRP 717
+ SD+L +G+ ++LE+ W +G G+FP +V P
Sbjct: 477 PQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTP 522
Score = 53.9 bits (128), Expect = 6e-07
Identities = 28/69 (40%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 720 AEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIF 779
A A ++P G KALY + G+ +L F GDII VD+ W GEL G G
Sbjct: 187 APAAKNPCLLPYG---KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFL 243
Query: 780 PKNYIQFLQ 788
P +YIQ +Q
Sbjct: 244 PASYIQCIQ 252
Score = 45.4 bits (106), Expect = 2e-04
Identities = 22/63 (34%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQI-GIFPANYVKVIIDIPEG 558
+ L+ + ++ D+L L GE+ +LEK W++G + R + G+FP NYV + +P G
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
Query: 559 GNG 561
G G
Sbjct: 530 GAG 532
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/62 (33%), Positives = 33/62 (53%), Gaps = 2/62 (3%)
Query: 577 VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEV--RGRTGIFPLNFVEPVEDYPTS 634
+A + Y ++ DEL +GE+ + E + W +G G +G+FP N+V PV P
Sbjct: 470 LALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAG 529
Query: 635 GA 636
GA
Sbjct: 530 GA 531
Score = 38.9 bits (89), Expect = 0.019
Identities = 23/90 (25%), Positives = 43/90 (47%), Gaps = 7/90 (7%)
Query: 703 LQDREGIFPAVFVRPCPAEAKSMLAIVPKGR-----KAKALYDFRGENEDELSFKAGDII 757
L + G F P SM AI P+ + + + + + ++E E+ K GDI+
Sbjct: 791 LHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEGDIV 850
Query: 758 TELESVDDDWMSGELM--GKSGIFPKNYIQ 785
+ +D W G L G++G+FP ++++
Sbjct: 851 FVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 37.0 bits (84), Expect = 0.071
Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 18/102 (17%)
Query: 616 RTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAE 675
+ G LNF P P S A + + LP E + S+ +
Sbjct: 794 KAGSLDLNFTSPSRQAPLSMAAI----------------RPEPKLLPRERYRVVVSYPPQ 837
Query: 676 TSDDLSFKRGDRIQILERLDSDWCRGRLQ--DREGIFPAVFV 715
+ ++ K GD + + ++ + W +G LQ R G+FP FV
Sbjct: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFV 879
Score = 35.4 bits (80), Expect = 0.21
Identities = 16/47 (34%), Positives = 29/47 (61%), Gaps = 2/47 (4%)
Query: 582 YIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVE 626
Y + + E+ EG+I+ + + + W +G ++ GRTG+FP +FVE
Sbjct: 834 YPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 35.0 bits (79), Expect = 0.27
Identities = 14/51 (27%), Positives = 31/51 (60%), Gaps = 2/51 (3%)
Query: 502 VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 550
V+ +P + ++ L G+IV++ +K + WY+G + + G+FP ++V+
Sbjct: 830 VVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 84.7 bits (208), Expect = 3e-16
Identities = 48/162 (29%), Positives = 84/162 (51%), Gaps = 15/162 (9%)
Query: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 564
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 825 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 882
Query: 565 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 622
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 883 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 942
Query: 623 NFVEPVE-----------DYPTSGANVLSTKVPLKTKKEDSG 653
+V+ ++ D P S + S + +E+SG
Sbjct: 943 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQPWREESG 984
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 647 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 706
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 808 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 860
Query: 707 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 761
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 861 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 920
Query: 762 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 788
VD++W G + G S GIFP Y+ ++
Sbjct: 921 QVDENWYEGRIPGTSRQGIFPITYVDVIK 949
Score = 69.7 bits (169), Expect = 1e-11
Identities = 38/140 (27%), Positives = 69/140 (49%), Gaps = 18/140 (12%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 873
Query: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 874 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 925
Query: 698 WCRGRL--QDREGIFPAVFV 715
W GR+ R+GIFP +V
Sbjct: 926 WYEGRIPGTSRQGIFPITYV 945
Score = 54.3 bits (129), Expect = 4e-07
Identities = 39/133 (29%), Positives = 66/133 (49%), Gaps = 8/133 (6%)
Query: 422 ANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRS 481
A D +Q EL ++GD++ + KQ + N+ E GE GRV + I L ++
Sbjct: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKA 878
Query: 482 RPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RN 539
+P + Q ++ G A+ +F + +++ GE + LL ++D +WY G +
Sbjct: 879 QPKKLTPVQV-LEYG--EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 935
Query: 540 QIGIFPANYVKVI 552
+ GIFP YV VI
Sbjct: 936 RQGIFPITYVDVI 948
Score = 45.8 bits (107), Expect = 2e-04
Identities = 54/232 (23%), Positives = 86/232 (37%), Gaps = 40/232 (17%)
Query: 323 LPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATR--RSNKKLPFNRSSSDMDLQKKQSNL 380
L PV+ +P P++ P P + + + R ++ R + KK
Sbjct: 952 LVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLK 1011
Query: 381 ATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVSQNPGELSCKRGD 440
+ + + S + D P +PG PL S + PG +
Sbjct: 1012 PSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAF-----------------PGSEA----- 1049
Query: 441 VLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHA 500
+QTE + + GE GR + P + R P+ +Q A
Sbjct: 1050 -----EQTERH----RGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQA--- 1097
Query: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 550
L+ + + D+L L G+IV ++EK D W+ G R Q G FP NYVK
Sbjct: 1098 --LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1147
Score = 43.9 bits (102), Expect = 6e-04
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 736 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 789
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 1096 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
Score = 35.4 bits (80), Expect = 0.21
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 1097 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1149
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 84.0 bits (206), Expect = 5e-16
Identities = 41/127 (32%), Positives = 73/127 (57%), Gaps = 4/127 (3%)
Query: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 564
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 803 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 860
Query: 565 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 622
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 861 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 920
Query: 623 NFVEPVE 629
+V+ ++
Sbjct: 921 TYVDVIK 927
Score = 77.8 bits (190), Expect = 4e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 647 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 706
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 786 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 838
Query: 707 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 761
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 839 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 898
Query: 762 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 788
VD++W G + G S GIFP Y+ ++
Sbjct: 899 QVDENWYEGRIPGTSRQGIFPITYVDVIK 927
Score = 70.1 bits (170), Expect = 8e-12
Identities = 50/207 (24%), Positives = 90/207 (43%), Gaps = 31/207 (14%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 851
Query: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 852 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 903
Query: 698 WCRGRL--QDREGIFPAVFV----RPC---PAEAKSMLAIVPKGRKAKALYDFRGENE-- 746
W GR+ R+GIFP +V RP P + + R A A F ++
Sbjct: 904 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLI 963
Query: 747 ----DELSFKAGDIITELESVDDDWMS 769
L + E+ +V +W+S
Sbjct: 964 TPAPSSLPHSRRALSPEMHAVTSEWIS 990
Score = 54.3 bits (129), Expect = 4e-07
Identities = 39/133 (29%), Positives = 66/133 (49%), Gaps = 8/133 (6%)
Query: 422 ANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRS 481
A D +Q EL ++GD++ + KQ + N+ E GE GRV + I L ++
Sbjct: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKA 856
Query: 482 RPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RN 539
+P + Q ++ G A+ +F + +++ GE + LL ++D +WY G +
Sbjct: 857 QPKKLTPVQV-LEYG--EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 913
Query: 540 QIGIFPANYVKVI 552
+ GIFP YV VI
Sbjct: 914 RQGIFPITYVDVI 926
Score = 43.9 bits (102), Expect = 6e-04
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 736 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 789
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1292
Score = 43.5 bits (101), Expect = 8e-04
Identities = 21/50 (42%), Positives = 29/50 (58%), Gaps = 2/50 (4%)
Query: 503 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 550
L+ + + D+L L G+IV ++EK D W+ G R Q G FP NYVK
Sbjct: 1239 LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
Score = 35.4 bits (80), Expect = 0.21
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.133 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,264,880
Number of Sequences: 37866
Number of extensions: 2341501
Number of successful extensions: 17238
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 281
Number of HSP's successfully gapped in prelim test: 870
Number of HSP's that attempted gapping in prelim test: 10372
Number of HSP's gapped (non-prelim): 5374
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.