Search of human proteins with 193083136

Search of human proteins with 193083136

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|193083136 leucine-rich repeat, immunoglobulin-like and
transmembrane domains 3 [Homo sapiens]
         (634 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|193083136 leucine-rich repeat, immunoglobulin-like and transm...  1266   0.0  
gi|14149694 retina specific protein PAL [Homo sapiens]                337   3e-92
gi|62988340 leucine rich repeat containing 22 [Homo sapiens]          191   2e-48
gi|31542244 leucine rich repeat and fibronectin type III domain ...   120   5e-27
gi|13375646 leucine rich repeat and fibronectin type III domain ...   117   3e-26
gi|194306623 immunoglobulin superfamily containing leucine-rich ...   114   4e-25
gi|194306621 immunoglobulin superfamily containing leucine-rich ...   114   4e-25
gi|39930401 immunoglobulin superfamily containing leucine-rich r...   114   4e-25
gi|194306618 immunoglobulin superfamily containing leucine-rich ...   114   4e-25
gi|27363458 leucine rich repeat and fibronectin type III domain ...   113   5e-25
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         107   4e-23
gi|149773484 leucine rich repeat and fibronectin type III domain...    99   9e-21
gi|55741571 leucine rich repeat and fibronectin type III domain ...    99   9e-21
gi|41582239 immunoglobulin superfamily containing leucine-rich r...    91   2e-18
gi|5031809 immunoglobulin superfamily containing leucine-rich re...    91   2e-18
gi|109150416 peroxidasin [Homo sapiens]                                88   3e-17
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...    88   3e-17
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho...    80   4e-15
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]              79   1e-14
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]              79   1e-14
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre...    78   2e-14
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec...    78   2e-14
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...    78   3e-14
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom...    75   1e-13
gi|4759146 slit homolog 2 [Homo sapiens]                               74   3e-13
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom...    74   3e-13
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          73   7e-13
gi|11321571 slit homolog 3 [Homo sapiens]                              73   9e-13
gi|188528675 slit homolog 1 [Homo sapiens]                             73   9e-13
gi|51317373 netrin-G1 ligand [Homo sapiens]                            72   2e-12

>gi|193083136 leucine-rich repeat, immunoglobulin-like and
           transmembrane domains 3 [Homo sapiens]
          Length = 634

 Score = 1266 bits (3275), Expect = 0.0
 Identities = 634/634 (100%), Positives = 634/634 (100%)

Query: 1   MDMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLK 60
           MDMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLK
Sbjct: 1   MDMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLK 60

Query: 61  QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 120
           QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL
Sbjct: 61  QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 120

Query: 121 TTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVL 180
           TTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVL
Sbjct: 121 TTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVL 180

Query: 181 LDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQI 240
           LDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQI
Sbjct: 181 LDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQI 240

Query: 241 TWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTV 300
           TWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTV
Sbjct: 241 TWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTV 300

Query: 301 LGITTTPIPPDTSERTGDHPEWDVQPGSGRSTSVSSASSYLWSSSFSPTSSFSASTLSPP 360
           LGITTTPIPPDTSERTGDHPEWDVQPGSGRSTSVSSASSYLWSSSFSPTSSFSASTLSPP
Sbjct: 301 LGITTTPIPPDTSERTGDHPEWDVQPGSGRSTSVSSASSYLWSSSFSPTSSFSASTLSPP 360

Query: 361 STASFSLSPFSSSTVSSTTTLSTSISASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPAS 420
           STASFSLSPFSSSTVSSTTTLSTSISASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPAS
Sbjct: 361 STASFSLSPFSSSTVSSTTTLSTSISASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPAS 420

Query: 421 TSKKEELALLDQTMLTETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLYSKYGGK 480
           TSKKEELALLDQTMLTETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLYSKYGGK
Sbjct: 421 TSKKEELALLDQTMLTETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLYSKYGGK 480

Query: 481 DLLLLNADSSKNQVTIDGLEPGGQYMACVCPKGVPPQKDQCITFSTERVEGDDSQWSLLL 540
           DLLLLNADSSKNQVTIDGLEPGGQYMACVCPKGVPPQKDQCITFSTERVEGDDSQWSLLL
Sbjct: 481 DLLLLNADSSKNQVTIDGLEPGGQYMACVCPKGVPPQKDQCITFSTERVEGDDSQWSLLL 540

Query: 541 VVTSTACVVILPLICFLLYKVCKLQCKSEPFWEDDLAKETYIQFETLFPRSQSVGELWTR 600
           VVTSTACVVILPLICFLLYKVCKLQCKSEPFWEDDLAKETYIQFETLFPRSQSVGELWTR
Sbjct: 541 VVTSTACVVILPLICFLLYKVCKLQCKSEPFWEDDLAKETYIQFETLFPRSQSVGELWTR 600

Query: 601 SHRDDSEKLLLCSRSSVESQVTFKSEGSRPEYYC 634
           SHRDDSEKLLLCSRSSVESQVTFKSEGSRPEYYC
Sbjct: 601 SHRDDSEKLLLCSRSSVESQVTFKSEGSRPEYYC 634


>gi|14149694 retina specific protein PAL [Homo sapiens]
          Length = 623

 Score =  337 bits (863), Expect = 3e-92
 Identities = 212/638 (33%), Positives = 321/638 (50%), Gaps = 68/638 (10%)

Query: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61
           DM   P ++P DT +LR+E+T IRR+  EAF  L  L+ LW+ YN+++ ++      L++
Sbjct: 49  DMTLPPASIPPDTSRLRLERTAIRRVPGEAFRPLGRLEQLWLPYNALSELNALMLRGLRR 108

Query: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121
           L ELRL GN LAAFPWA+L D P LR LDL  N++++VP EA R+L+NL +LDLSSN+L 
Sbjct: 109 LRELRLPGNRLAAFPWAALRDAPKLRLLDLQANRLSAVPAEAARFLENLTFLDLSSNQLM 168

Query: 122 TLPPDFLESWTHLVS--TPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIV 179
            LP + + SW HL +   P G       R +LGLQDNPW CDC +  ++ L     P + 
Sbjct: 169 RLPQELIVSWAHLETGIFPPG----HHPRRVLGLQDNPWACDCRLYDLVHLLDGWAPNLA 224

Query: 180 LLDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQ 239
            ++  + C+ P  L G+ F + EL  C  P +      I S LG   LLRC ATG P P+
Sbjct: 225 FIETELRCASPRSLAGVAFSQLELRKCQGPELHPGVASIRSLLGGTALLRCGATGVPGPE 284

Query: 240 ITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVT 299
           ++W R++  P+N TV QE   +G  W+++ L  +S  D+GDY C+AKN  G SE V+++ 
Sbjct: 285 MSWRRANGRPLNGTVHQEVSSDGTSWTLLGLPAVSHLDSGDYICQAKNFLGASETVISLI 344

Query: 300 VLGITTTPIPPDTSERTGDHPEWDVQPGSGRSTSVSSASSYLWSSSFSPTSSFSASTLSP 359
           V        PP ++E +G       + G G       A++Y            +      
Sbjct: 345 VTE------PPTSTEHSGSPGALWARTGGG-----GEAAAY-------NNKLVARHVPQI 386

Query: 360 PSTASFSLSPFSSSTVSSTTTLSTSISASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPA 419
           P  A  +  P   ST    T     + A   +++ R+      G    ++ +        
Sbjct: 387 PKPAVLATGPSVPSTKEELTLEHFQMDALGELSDGRA------GPSEARMVR-------- 432

Query: 420 STSKKEELALLDQTMLTETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLYSKYGG 479
                                   +++VV +T  SV+L W      + +A +VLY+ +G 
Sbjct: 433 ------------------------SVKVVGDTYHSVSLVWKAPQAKNTTAFSVLYAVFGQ 468

Query: 480 KDLLLLNADSSKNQVTIDGLEPGGQYMACVCPKGVPPQKDQCITFST-ERVEGDDSQWSL 538
             +  +     K +VTI GL P  +Y+ACVC +G+ P+K+QC+ FST E V+ +++Q  +
Sbjct: 469 HSMRRVIVQPGKTRVTITGLLPKTKYVACVCVQGLVPRKEQCVIFSTNEVVDAENTQQLI 528

Query: 539 LLVVTSTACVVILPLICFLLYKVCKLQCKSEPFWEDDLAKETYIQFETLFPRSQSVGELW 598
            +VV S A V+ LPL   +     + +C+     +   A  TY+  E L      + EL 
Sbjct: 529 NVVVISVAIVIALPLTLLVCCSALQKRCRKCFNKDSTEATVTYVNLERLGYSEDGLEEL- 587

Query: 599 TRSHRDDSEKLLLCSRSSVESQVTFKSEGSR--PEYYC 634
              H       LL +RSSV+ Q  F  +G R   EY+C
Sbjct: 588 -SRHSVSEADRLLSARSSVDFQ-AFGVKGGRRINEYFC 623


>gi|62988340 leucine rich repeat containing 22 [Homo sapiens]
          Length = 550

 Score =  191 bits (484), Expect = 2e-48
 Identities = 101/302 (33%), Positives = 161/302 (53%), Gaps = 3/302 (0%)

Query: 1   MDMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLK 60
           + + ++P NL  +  ++RIE + +  +   +F  +  L+YLW+ +N+++ I   +  +L 
Sbjct: 44  VSLGKIPGNLSEEFKQVRIENSPLFEMPQGSFINMSTLEYLWLNFNNISVIHLGALEHLP 103

Query: 61  QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 120
           +L ELRL+GN L + PW +    PLLR LDL  NKI ++P  AL++L +L YLDLSSNRL
Sbjct: 104 ELRELRLEGNKLCSVPWTAFRATPLLRVLDLKRNKIDALPELALQFLVSLTYLDLSSNRL 163

Query: 121 TTLPPDFLESWT--HLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAI 178
           T +      +W        P    ++  S +++ L DNPW CDC +  +++  K +   +
Sbjct: 164 TVVSKSVFLNWPAYQKCRQPDCGAEIL-SSLVVALHDNPWVCDCRLRGLVQFVKSITLPV 222

Query: 179 VLLDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTP 238
           +L++  + C  P    G LF   EL  C+KP + T +  I    G NV LRC A   P+P
Sbjct: 223 ILVNSYLICQGPLSKAGQLFHETELSACMKPQISTPSANITIRAGQNVTLRCLAQASPSP 282

Query: 239 QITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTV 298
            I WT   S    + V+  S  E    S +++      D+G+Y C A N  G S  V+++
Sbjct: 283 SIAWTYPLSMWREFDVLTSSTGEDTALSELAIPAAHLVDSGNYTCMASNSIGKSNLVISL 342

Query: 299 TV 300
            V
Sbjct: 343 HV 344



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 40/119 (33%), Positives = 57/119 (47%), Gaps = 6/119 (5%)

Query: 436 TETNAAIENLRVVSETKESVTLTWNMINTTHNSAVTVLY---SKYGGKDLLLLNADSSKN 492
           +E NA I+ LRVV +T   + L W  +  T       LY    +   K+++ +      N
Sbjct: 360 SEGNAYID-LRVVKQTVHGILLEWLAVADTSKEEWFTLYIASDEAFRKEVVHIGPGI--N 416

Query: 493 QVTIDGLEPGGQYMACVCPKGVPPQKDQCITFSTERVEGDDSQWSLLLVVTSTACVVIL 551
              +D L PG +Y AC+  +G PP + QC+ F T R  G       LL VT   CVV+L
Sbjct: 417 TYAVDDLLPGTKYEACLSLEGQPPHQGQCVAFVTGRDAGGLEAREHLLHVTVVLCVVLL 475


>gi|31542244 leucine rich repeat and fibronectin type III domain
           containing 5 [Homo sapiens]
          Length = 719

 Score =  120 bits (300), Expect = 5e-27
 Identities = 105/358 (29%), Positives = 161/358 (44%), Gaps = 28/358 (7%)

Query: 17  LRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFP 76
           L +    + +I+ + F  L  L +L +  N +  I  ++F ++  L EL L  N+L   P
Sbjct: 104 LHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIP 163

Query: 77  WASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVS 136
           W ++  M  L TL L +N I ++P     +L  +  LD++SN+L  LPPD L     +++
Sbjct: 164 WDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQKLPPDPLFQRAQVLA 223

Query: 137 TPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGI 196
           T SG+  +SPS   L    NP  C+C +  +  LS+         D L TC+ P  LTG 
Sbjct: 224 T-SGI--ISPSTFALSFGGNPLHCNCELLWLRRLSRE--------DDLETCASPPLLTGR 272

Query: 197 LF-QRAELEHCLKPSVMTSATKIMSAL-GSNVLLRCDATGFPTPQITWTRSDSSPVNYTV 254
            F    E E   +P ++T  T  M  L G    LRC A G P P I W   +   ++   
Sbjct: 273 YFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNAT 332

Query: 255 IQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSE 314
                + G     + +   + KD G + C A N AG +  +V + ++ +      P    
Sbjct: 333 RSLVYDNGT----LDILITTVKDTGAFTCIASNPAGEATQIVDLHIIKL------PHLLN 382

Query: 315 RTGDHPEWDVQPGSGR-STSVSSASSYLWSSSFSPTSSFSASTLSPPSTASFSLSPFS 371
            T    E D  PGS   STS  S S+   SSS   T       +   +T+S +L  F+
Sbjct: 383 STNHIHEPD--PGSSDISTSTKSGSN--TSSSNGDTKLSQDKIVVAEATSSTALLKFN 436


>gi|13375646 leucine rich repeat and fibronectin type III domain
           containing 3 [Homo sapiens]
          Length = 628

 Score =  117 bits (293), Expect = 3e-26
 Identities = 97/309 (31%), Positives = 143/309 (46%), Gaps = 24/309 (7%)

Query: 35  LVELQYLWVTYNSVASIDPSSFYNLKQ-LHELRLDGNSLAAFPWASLLDMPLLRTLDLHN 93
           LV L++L ++ N +A++   +  +  + L +L L  N+L   PW +L  +  + TL L +
Sbjct: 130 LVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDH 189

Query: 94  NKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVSTPSGVLDLSP-SRIILG 152
           N + SVP  A   L  LA LD++SNRLTT+PPD L S   L++ P G    SP S ++L 
Sbjct: 190 NLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRG----SPASALVLA 245

Query: 153 LQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQR-AELEHCLKPSV 211
              NP  C+C +  +  L++         D L  C+ P  L G  F    E E   +P V
Sbjct: 246 FGGNPLHCNCELVWLRRLARE--------DDLEACASPPALGGRYFWAVGEEEFVCEPPV 297

Query: 212 MTSATKIMSA-LGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGVRWSIMSL 270
           +T  +  ++   G    LRC A G P P++ W     SP    +   S         + L
Sbjct: 298 VTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWV----SPQGRLLGNSSRARAFPNGTLEL 353

Query: 271 TGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSERTGDHPEWDVQPGSGR 330
                 D G + C A N AG + A V +TV      P PP  +  T   P  D  P +  
Sbjct: 354 LVTEPGDGGIFTCIAANAAGEATAAVELTV----GPPPPPQLANSTSCDPPRDGDPDALT 409

Query: 331 STSVSSASS 339
             S +SAS+
Sbjct: 410 PPSAASASA 418


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  114 bits (284), Expect = 4e-25
 Identities = 95/390 (24%), Positives = 157/390 (40%), Gaps = 71/390 (18%)

Query: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61
           ++ E+P  LP +   L +    I  +   AF  + ++  LW+ +N V +++P +   L Q
Sbjct: 41  ELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQ 100

Query: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121
           L  L L  N +++FPW+ L ++  L+ L +++N++ S+P +AL  L +L  L +++NRL 
Sbjct: 101 LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLR 160

Query: 122 TLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLL 181
           TL P              G  D   +   L L  NP+ C C +  +   +      + L 
Sbjct: 161 TLAP--------------GTFDALSALSHLQLYHNPFHCGCGLVWL--QAWAASTRVSLP 204

Query: 182 DP-LMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNV------LLRCDATG 234
           +P  + C+ P  L G+   R     C  PSV  SA   + A G+ +      +L C A G
Sbjct: 205 EPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADG 264

Query: 235 FPTPQITWT-----------------------------RSDSSPVNYTVIQESPEEGVRW 265
            PTP++ W                                D   +  T  Q +P     W
Sbjct: 265 HPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQ-TPTPAPAW 323

Query: 266 SIMSLTG--------------ISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPD 311
                T               +S+K+AG Y C+A N  G +   + V V        PP 
Sbjct: 324 PAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATG----PPK 379

Query: 312 TSERTGDHPEWDVQPGSGRSTSVSSASSYL 341
            +   G  P+        +ST+    +S L
Sbjct: 380 HAPGAGGEPDGQAPTSERKSTAKGRGNSVL 409


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  114 bits (284), Expect = 4e-25
 Identities = 95/390 (24%), Positives = 157/390 (40%), Gaps = 71/390 (18%)

Query: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61
           ++ E+P  LP +   L +    I  +   AF  + ++  LW+ +N V +++P +   L Q
Sbjct: 41  ELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQ 100

Query: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121
           L  L L  N +++FPW+ L ++  L+ L +++N++ S+P +AL  L +L  L +++NRL 
Sbjct: 101 LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLR 160

Query: 122 TLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLL 181
           TL P              G  D   +   L L  NP+ C C +  +   +      + L 
Sbjct: 161 TLAP--------------GTFDALSALSHLQLYHNPFHCGCGLVWL--QAWAASTRVSLP 204

Query: 182 DP-LMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNV------LLRCDATG 234
           +P  + C+ P  L G+   R     C  PSV  SA   + A G+ +      +L C A G
Sbjct: 205 EPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADG 264

Query: 235 FPTPQITWT-----------------------------RSDSSPVNYTVIQESPEEGVRW 265
            PTP++ W                                D   +  T  Q +P     W
Sbjct: 265 HPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQ-TPTPAPAW 323

Query: 266 SIMSLTG--------------ISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPD 311
                T               +S+K+AG Y C+A N  G +   + V V        PP 
Sbjct: 324 PAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATG----PPK 379

Query: 312 TSERTGDHPEWDVQPGSGRSTSVSSASSYL 341
            +   G  P+        +ST+    +S L
Sbjct: 380 HAPGAGGEPDGQAPTSERKSTAKGRGNSVL 409


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  114 bits (284), Expect = 4e-25
 Identities = 95/390 (24%), Positives = 157/390 (40%), Gaps = 71/390 (18%)

Query: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61
           ++ E+P  LP +   L +    I  +   AF  + ++  LW+ +N V +++P +   L Q
Sbjct: 41  ELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQ 100

Query: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121
           L  L L  N +++FPW+ L ++  L+ L +++N++ S+P +AL  L +L  L +++NRL 
Sbjct: 101 LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLR 160

Query: 122 TLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLL 181
           TL P              G  D   +   L L  NP+ C C +  +   +      + L 
Sbjct: 161 TLAP--------------GTFDALSALSHLQLYHNPFHCGCGLVWL--QAWAASTRVSLP 204

Query: 182 DP-LMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNV------LLRCDATG 234
           +P  + C+ P  L G+   R     C  PSV  SA   + A G+ +      +L C A G
Sbjct: 205 EPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADG 264

Query: 235 FPTPQITWT-----------------------------RSDSSPVNYTVIQESPEEGVRW 265
            PTP++ W                                D   +  T  Q +P     W
Sbjct: 265 HPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQ-TPTPAPAW 323

Query: 266 SIMSLTG--------------ISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPD 311
                T               +S+K+AG Y C+A N  G +   + V V        PP 
Sbjct: 324 PAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATG----PPK 379

Query: 312 TSERTGDHPEWDVQPGSGRSTSVSSASSYL 341
            +   G  P+        +ST+    +S L
Sbjct: 380 HAPGAGGEPDGQAPTSERKSTAKGRGNSVL 409


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  114 bits (284), Expect = 4e-25
 Identities = 95/390 (24%), Positives = 157/390 (40%), Gaps = 71/390 (18%)

Query: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61
           ++ E+P  LP +   L +    I  +   AF  + ++  LW+ +N V +++P +   L Q
Sbjct: 41  ELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQ 100

Query: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121
           L  L L  N +++FPW+ L ++  L+ L +++N++ S+P +AL  L +L  L +++NRL 
Sbjct: 101 LKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLR 160

Query: 122 TLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLL 181
           TL P              G  D   +   L L  NP+ C C +  +   +      + L 
Sbjct: 161 TLAP--------------GTFDALSALSHLQLYHNPFHCGCGLVWL--QAWAASTRVSLP 204

Query: 182 DP-LMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNV------LLRCDATG 234
           +P  + C+ P  L G+   R     C  PSV  SA   + A G+ +      +L C A G
Sbjct: 205 EPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADG 264

Query: 235 FPTPQITWT-----------------------------RSDSSPVNYTVIQESPEEGVRW 265
            PTP++ W                                D   +  T  Q +P     W
Sbjct: 265 HPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQ-TPTPAPAW 323

Query: 266 SIMSLTG--------------ISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPD 311
                T               +S+K+AG Y C+A N  G +   + V V        PP 
Sbjct: 324 PAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATG----PPK 379

Query: 312 TSERTGDHPEWDVQPGSGRSTSVSSASSYL 341
            +   G  P+        +ST+    +S L
Sbjct: 380 HAPGAGGEPDGQAPTSERKSTAKGRGNSVL 409


>gi|27363458 leucine rich repeat and fibronectin type III domain
           containing 4 [Homo sapiens]
          Length = 635

 Score =  113 bits (283), Expect = 5e-25
 Identities = 89/271 (32%), Positives = 130/271 (47%), Gaps = 22/271 (8%)

Query: 36  VELQYLWVTYNSVASIDPSSFYN-LKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNN 94
           V LQ+L ++ N +  I P +F + L+ L +L L  N+L   PWA +  MP L TL+L +N
Sbjct: 120 VNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHN 179

Query: 95  KITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQ 154
            I ++P  A   L  L+ LDL+SNRL TL PD L S            + SP+ ++L   
Sbjct: 180 LIDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLFS-------RGRDAEASPAPLVLSFS 232

Query: 155 DNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQRA-ELEHCLKPSVMT 213
            NP  C+C   +++ L ++  P     D L TC+ P  L G  F    E E   +P ++ 
Sbjct: 233 GNPLHCNC---ELLWLRRLARP-----DDLETCASPPGLAGRYFWAVPEGEFSCEPPLIA 284

Query: 214 SATKIMSAL-GSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTG 272
             T+ +  L G    LRC A G P P + W   D   V  +    +   G     + +  
Sbjct: 285 RHTQRLWVLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGT----LEIGV 340

Query: 273 ISSKDAGDYKCKAKNLAGMSEAVVTVTVLGI 303
             + DAG Y C A N AG + A V + VL +
Sbjct: 341 TGAGDAGGYTCIATNPAGEATARVELRVLAL 371


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  107 bits (266), Expect = 4e-23
 Identities = 89/345 (25%), Positives = 147/345 (42%), Gaps = 37/345 (10%)

Query: 16  KLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAF 75
           +L +    +R + A AF     L  L +T N +  +   +F  L QL  L L GN LA  
Sbjct: 78  RLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARL 137

Query: 76  PWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLV 135
              + L +P L+ L L  N I  + ++AL  L +LA LDLS N+L T+  + L+    L 
Sbjct: 138 LDFTFLHLPRLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQ 197

Query: 136 STPSGVLDLSPSRIILGLQDNPWFCDCHISKM-IELSKVVDPAIVLLDPLMTCSEPERLT 194
                         +L L +NPW CDC +  +   + +     +   D  + C+EP RL 
Sbjct: 198 --------------VLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLA 243

Query: 195 GILFQRAELEH----CLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPV 250
             L    ++ H    C+ PSV     ++ + LG ++ + C A+G+P P +TW +      
Sbjct: 244 --LQSLLDVSHSSLICIPPSVHVQPLELTANLGEDLRVACQASGYPQPLVTWRKVPQPRE 301

Query: 251 NYTVIQESPEEGVRW-----------SIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVT 299
                Q   E G+              ++ L+ I+   AG Y+C+A N  G +     + 
Sbjct: 302 GRPRAQAQLEGGLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLL 361

Query: 300 VLGITTTP-----IPPDTSERTGDHPEWDVQPGSGRSTSVSSASS 339
           V      P      PP  +   G  P  +    + R+  V++ ++
Sbjct: 362 VNASRQQPQQPAQPPPPAARPAGSEPRPEAGSMAFRALGVATQTA 406


>gi|149773484 leucine rich repeat and fibronectin type III domain
           containing 1 [Homo sapiens]
          Length = 771

 Score = 99.4 bits (246), Expect = 9e-21
 Identities = 84/301 (27%), Positives = 133/301 (44%), Gaps = 28/301 (9%)

Query: 17  LRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYN-LKQLHELRLDGNSLAAF 75
           L ++   +  +  +    L  L++L +  N +  ++ ++F   L  + +L L  N+L A 
Sbjct: 118 LHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEAL 177

Query: 76  PWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPD--FLESWTH 133
           PW ++  M  L TL L +N I  +       L  L  LD++SNRL  LPPD  FL S   
Sbjct: 178 PWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRS--- 234

Query: 134 LVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERL 193
                 G     P+ + +    NP  C+C +  +  L++         D L TC+ PE L
Sbjct: 235 -----QGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTRE--------DDLETCATPEHL 281

Query: 194 TGILF-QRAELEHCLKPSVMT--SATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPV 250
           T   F    E E   +P ++T  +  + +   G  V LRC A G P P + W   D    
Sbjct: 282 TDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWVAPDG--- 338

Query: 251 NYTVIQESPEEGVRW-SIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIP 309
              ++  S    VR    + +T  + +D+G + C A N AG + A V V V+ +     P
Sbjct: 339 --RLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPP 396

Query: 310 P 310
           P
Sbjct: 397 P 397


>gi|55741571 leucine rich repeat and fibronectin type III domain
           containing 2 [Homo sapiens]
          Length = 789

 Score = 99.4 bits (246), Expect = 9e-21
 Identities = 93/327 (28%), Positives = 140/327 (42%), Gaps = 32/327 (9%)

Query: 17  LRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYN-LKQLHELRLDGNSLAAF 75
           L ++   +  +  +    LV LQ+L V  N +  I   +F + L  L +L L  N+L   
Sbjct: 105 LHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGL 164

Query: 76  PWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPD--FLESW-T 132
           PW S+  M  L  L L +N +  +       L+ LA LDL+SNRL  LPPD  F  S  +
Sbjct: 165 PWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQAS 224

Query: 133 HLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPER 192
            L +TP      +P  +      NP  C+C +  +  L +         D L TC  P  
Sbjct: 225 ALTATP-----FAPP-LSFSFGGNPLHCNCELLWLRRLERD--------DDLETCGSPGG 270

Query: 193 LTGILFQRAELEH--CLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPV 250
           L G  F     E   C  P +     K++   G    L+C A G P+P I W   D   V
Sbjct: 271 LKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLV 330

Query: 251 NYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGI------T 304
             +      + G     + +   +S+D+G + C A N AG + A+V V+++ +      T
Sbjct: 331 GNSSRTAVYDNGT----LDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNST 386

Query: 305 TTPIPPDT--SERTGDHPEWDVQPGSG 329
           +   PP +  S+ TG         GSG
Sbjct: 387 SRTAPPKSRLSDITGSSKTSRGGGGSG 413


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 80/323 (24%), Positives = 126/323 (39%), Gaps = 42/323 (13%)

Query: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61
           D+  +P   P +   L +    +  +   AF  +  LQ LW+ +N + ++   +  +L  
Sbjct: 40  DLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSH 99

Query: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121
           L  L L  N ++ F W+ L ++  L+ L + +N++T +P +A R L+ L  L L+ NRL 
Sbjct: 100 LKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLH 159

Query: 122 TLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLL 181
           TL        T L                L + +NP+ C C I  +   +     +I   
Sbjct: 160 TLAEGTFTPLTALSH--------------LQINENPFDCTCGIVWLKTWALTTAVSIPEQ 205

Query: 182 DPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSAL----GSNVLLRCDATGFPT 237
           D +  C+ P  L G    R     C  PSV  S            G  + L CD  G P 
Sbjct: 206 DNI-ACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPA 264

Query: 238 PQITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSK--------------------D 277
           PQ+ W     S +   V   SP  G     +  T ++S                     +
Sbjct: 265 PQLHWHIQIPSGI---VEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLE 321

Query: 278 AGDYKCKAKNLAGMSEAVVTVTV 300
            G Y C A N  G +E+ V V +
Sbjct: 322 EGTYSCLATNELGSAESSVDVAL 344


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 80/323 (24%), Positives = 126/323 (39%), Gaps = 42/323 (13%)

Query: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61
           D+  +P   P +   L +    +  +   AF  +  LQ LW+ +N + ++   +  +L  
Sbjct: 40  DLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRTVAAGALASLSH 99

Query: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121
           L  L L  N ++ F W+ L ++  L+ L + +N++T +P +A R L+ L  L L+ NRL 
Sbjct: 100 LKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRDAFRSLRALRSLQLNHNRLH 159

Query: 122 TLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLL 181
           TL        T L                L + +NP+ C C I  +   +     +I   
Sbjct: 160 TLAEGTFTPLTALSH--------------LQINENPFDCTCGIVWLKTWALTTAVSIPEQ 205

Query: 182 DPLMTCSEPERLTGILFQRAELEHCLKPSVMTSATKIMSAL----GSNVLLRCDATGFPT 237
           D +  C+ P  L G    R     C  PSV  S            G  + L CD  G P 
Sbjct: 206 DNI-ACTSPHVLKGTPLSRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPA 264

Query: 238 PQITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSK--------------------D 277
           PQ+ W     S +   V   SP  G     +  T ++S                     +
Sbjct: 265 PQLHWHIQIPSGI---VEITSPNVGTDGRALPGTPVASSQPRFQAFANGSLLIPDFGKLE 321

Query: 278 AGDYKCKAKNLAGMSEAVVTVTV 300
            G Y C A N  G +E+ V V +
Sbjct: 322 EGTYSCLATNELGSAESSVDVAL 344


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 78/289 (26%), Positives = 123/289 (42%), Gaps = 26/289 (8%)

Query: 45  YNSVASIDPSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEAL 104
           +N +  I P +F  L+ L+ L L+ N +   P  +  D+  L+ L L+ N+I S+  +A 
Sbjct: 71  FNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAF 130

Query: 105 RYLKNLAYLDLSSNRLTTLPPD-----------FLES--WTHLVSTPSGVLDLSPSRIIL 151
           + L +L  L L  N++ TL PD           FL +   THLV    G  +   S   L
Sbjct: 131 KGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLV---PGTFNHLESMKRL 187

Query: 152 GLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTG--ILFQRAELEHCLKP 209
            L  N   CDC I  + +L K    +         C  P R+ G  +     E  +C +P
Sbjct: 188 RLDSNTLHCDCEILWLADLLKTYAES-GNAQAAAICEYPRRIQGRSVATITPEELNCERP 246

Query: 210 SVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGVRWSIMS 269
            + +         G+ V   C A G P P+I W R+++     ++  +S    +    + 
Sbjct: 247 RITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNN---ELSMKTDSRLNLLDDGTLM 303

Query: 270 LTGISSKDAGDYKCKAKNLAG-MSEAVVTVTVLGITTTP---IPPDTSE 314
           +      D G Y+C AKN+AG +    VT+   G    P   I P  +E
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTE 352



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 90/354 (25%), Positives = 132/354 (37%), Gaps = 65/354 (18%)

Query: 17  LRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFP 76
           L +    I+RI + AF  L  L+YL++  N + SID  +F  L  L +L L  N +    
Sbjct: 91  LLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLD 150

Query: 77  WASLLDMPLLRTLDLHNNKITS-VPN--------EALRYLKNLAYLDLSSNRLTTLPPDF 127
             S   +P L  L LHNN+IT  VP         + LR   N  + D     L  L   +
Sbjct: 151 PDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTY 210

Query: 128 LESWTHLVST---------PSGVLDLSPS-------RIILGLQD------NPWFCDCH-- 163
            ES     +             V  ++P        RI    QD      N  +  C   
Sbjct: 211 AESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAE 270

Query: 164 ---------ISKMIELSKVVDPAIVLLDP--LMTCSEPERLTGIL------------FQR 200
                    +    ELS   D  + LLD   LM  +  E   GI              Q 
Sbjct: 271 GNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQE 330

Query: 201 AELEHCLKPSVMTSATKIMSA---LGSNVLLRCDATGFPTPQITWTRSDSSPVNYTV-IQ 256
             L +   P+  T   +  +    +G +V L C ATG P P+I+WTR D +P+     + 
Sbjct: 331 VTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVN 390

Query: 257 ESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPP 310
            +P  G     + +  +   D+G+Y C A N      A   + V  +    + P
Sbjct: 391 ITPSGG-----LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTP 439



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 28/98 (28%), Positives = 45/98 (45%), Gaps = 8/98 (8%)

Query: 223 GSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDYK 282
           G  V  +C+A G P P I WT+  S      +  +     +    + ++G++  D G Y+
Sbjct: 447 GQTVDFQCEAKGNPPPVIAWTKGGSQ-----LSVDRRHLVLSSGTLRISGVALHDQGQYE 501

Query: 283 CKAKNLAGMSEAVVTVTVLGITT---TPIPPDTSERTG 317
           C+A N+ G  + V  +TV    T     IP DT+   G
Sbjct: 502 CQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVG 539



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 23/79 (29%), Positives = 37/79 (46%), Gaps = 5/79 (6%)

Query: 222 LGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGISSKDAGDY 281
           +G+NV L C + G P P ITW +             SPE       +++  +   DAG Y
Sbjct: 538 VGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPE-----GFLTINDVGPADAGRY 592

Query: 282 KCKAKNLAGMSEAVVTVTV 300
           +C A+N  G +   + ++V
Sbjct: 593 ECVARNTIGSASVSMVLSV 611



 Score = 30.0 bits (66), Expect = 6.8
 Identities = 17/51 (33%), Positives = 26/51 (50%)

Query: 84  PLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHL 134
           P    LDL  N+I  +   A R L+NL  L L++N++  +P    E   +L
Sbjct: 62  PQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENL 112


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 89/355 (25%), Positives = 155/355 (43%), Gaps = 58/355 (16%)

Query: 16  KLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAF 75
           +L +E   + R++    Y L  LQ L+V+ N++  I P ++   ++L EL L  N L   
Sbjct: 267 ELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRL 326

Query: 76  PWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLV 135
             ++ + + LL  L+L +N++T + +   R+L NL  LDL +N ++    D  E++  L 
Sbjct: 327 DESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLT 386

Query: 136 STPSGVL----------------------DLSPSRIILGLQDNPW--------------- 158
           S    +L                      DL+ +  I+ +Q+N +               
Sbjct: 387 SLTKLILQGNQIKSITKKAFIGLESLEHLDLN-NNAIMSIQENAFSQTHLKELILNTSSL 445

Query: 159 FCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQRAEL-----EHCLKPSVMT 213
            CDCH+  +++   +VD         ++C+ PE L G      +L     +  LKP + T
Sbjct: 446 LCDCHLKWLLQW--LVDNNFQH-SVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRT 502

Query: 214 SATKIMSALGSNVLLRCDA-TGFPTPQITWTRSDSSPV------NYTVIQESPEEGVRW- 265
               I++  G NV L C A +   +P  T  R DS  +      N+    +   E + + 
Sbjct: 503 HPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYT 562

Query: 266 SIMSLTGISSKDAGDYKCKAKNLAGMS---EAVVTVTVLGITTTPIPPDTSERTG 317
           SI+ L  ++  D G Y+C   N  G +   +A +TV  +  +    P D + RTG
Sbjct: 563 SILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMP-SFLKTPMDLTIRTG 616



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 29/107 (27%), Positives = 54/107 (50%)

Query: 17  LRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFP 76
           L +++  I+ +    F  L  L+ L +  N ++ +   +F+ L  + EL L+ N+L    
Sbjct: 220 LELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVN 279

Query: 77  WASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTL 123
              L  + +L+ L +  N I  +  +A  + + L+ LDLS N+LT L
Sbjct: 280 KGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRL 326



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 30/106 (28%), Positives = 48/106 (45%), Gaps = 7/106 (6%)

Query: 199 QRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQITWTR---SDSSPVNYTVI 255
           Q+A+L     PS + +   +    G+   L C A G P PQI+W +   +D        +
Sbjct: 592 QKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRM 651

Query: 256 QESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVL 301
              PE+     +  +  +  +D G Y C A+N AG   A  ++TVL
Sbjct: 652 HVMPED----DVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVL 693



 Score = 37.0 bits (84), Expect = 0.056
 Identities = 25/111 (22%), Positives = 41/111 (36%), Gaps = 4/111 (3%)

Query: 191 ERLTGILFQRAELEHCLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPV 250
           +   G L   A L     PS +          G   +L+C A G P P++ WT+ D    
Sbjct: 678 QNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGP-- 735

Query: 251 NYTVIQESPEEGVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVL 301
              ++ E         ++ +     +DAG Y C   N  G     + + V+
Sbjct: 736 --LLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVI 784



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 29/90 (32%), Positives = 46/90 (51%), Gaps = 10/90 (11%)

Query: 38  LQYLWVTYNSVASI----DPSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHN 93
           LQ + + YN +  I    +P+S   L     L L  N +      +L   P L +LDL +
Sbjct: 99  LQEVKMNYNELTEIPYFGEPTSNITL-----LSLVHNIIPEINAQALQFYPALESLDLSS 153

Query: 94  NKITSVPNEALRYLKNLAYLDLSSNRLTTL 123
           N I+ +   +   ++ L YL+LS+NR+TTL
Sbjct: 154 NIISEIKTSSFPRMQ-LKYLNLSNNRITTL 182


>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
           sapiens]
          Length = 674

 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 67/212 (31%), Positives = 107/212 (50%), Gaps = 26/212 (12%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVAS--IDPSSFYNLK 60
           ++ +P+ LP    +LR++   I  I   AF  L  L+ L +  N +A+  I   +F  L+
Sbjct: 189 LSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQ 248

Query: 61  QLHELRLDGNSLAAFPWASLLDMPL--LRTLDLHNNKITSVPNEALRYLKNLAYLDLSSN 118
            L EL L  NSLAA P    L++P   L+ L L +N I+ +P   L  ++ L  LDLS+N
Sbjct: 249 NLTELSLVRNSLAAPP----LNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNN 304

Query: 119 RLTTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAI 178
            LTTLP    +   +L                L L++NPWFC C++  + +  K    A+
Sbjct: 305 NLTTLPRGLFDDLGNLAQ--------------LLLRNNPWFCGCNLMWLRDWVK-ARAAV 349

Query: 179 VLLDPLMTCSEPERLTGILFQ--RAELEHCLK 208
           V +  LM C  PE++ G+  +   +E++ C +
Sbjct: 350 VNVRGLM-CQGPEKVRGMAIKDITSEMDECFE 380



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 47/228 (20%), Positives = 85/228 (37%), Gaps = 40/228 (17%)

Query: 386 SASTTMANKRSFQLHQGGKRNLKVAKNGSKLPPASTSKKEELALLDQTMLTETNAAIENL 445
           +A TT +N  S    QG    LK  + G +LP ++         +D  M T   A    +
Sbjct: 391 AAKTTASNHASATTPQGSLFTLKAKRPGLRLPDSN---------IDYPMATGDGAKTLAI 441

Query: 446 RVVSETKESVTLTWNMINTTHNSAVTVLYSKYGGKDLL------LLNADSSKNQVTIDGL 499
            V + T +S+ +TW    T   S+  + + + G    +      L+  D  K +  +  L
Sbjct: 442 HVKALTADSIRITWKA--TLPASSFRLSWLRLGHSPAVGSITETLVQGD--KTEYLLTAL 497

Query: 500 EPGGQYMAC----------------VCPKG-VPPQKDQCITFSTERVEGDDSQWSLLLVV 542
           EP   Y+ C                VC K           T + E+  G  +   L  ++
Sbjct: 498 EPKSTYIICMVTMETSNAYVADETPVCAKAETADSYGPTTTLNQEQNAGPMASLPLAGII 557

Query: 543 TSTACVV----ILPLICFLLYKVCKLQCKSEPFWEDDLAKETYIQFET 586
                +V    +L  IC+ +++  +L  +   +      K+ Y++  T
Sbjct: 558 GGAVALVFLFLVLGAICWYVHQAGELLTRERAYNRGSRKKDDYMESGT 605


>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 73/290 (25%), Positives = 128/290 (44%), Gaps = 37/290 (12%)

Query: 24  IRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDG-NSLAAFPWASLLD 82
           + R+   A   +  L++L +  N +  + P  F N+  L EL L+    L +    +L++
Sbjct: 249 LARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVN 308

Query: 83  MPLLRTLDLHNN-KITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVSTPSGV 141
           +P L  LD+ NN +++ +   A  +L  +  L L++N L+ L    +ES  +L       
Sbjct: 309 LPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE----- 363

Query: 142 LDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMT-CSEPERLTGILFQ- 199
                    +GL  NP  CDC    +I  +      +  ++P  T C+EP  L  +  + 
Sbjct: 364 ---------VGLHGNPIRCDC----VIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVRE 410

Query: 200 ---RAELEHCLKP-SVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVI 255
              R   +HCL   S  +    +  A G +++L C A   P P+I W     +P    + 
Sbjct: 411 VPFREMTDHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWV----TPAGLRLT 466

Query: 256 QESPEEGVRWSI-----MSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTV 300
                 G R+ +     + L  +++++AG Y C A+NL G     V+V V
Sbjct: 467 PA--HAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 37/132 (28%), Positives = 58/132 (43%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQL 62
           +  +P  LP  T  L ++   I R+      YL  L  L ++ NS +      F+ L QL
Sbjct: 60  LTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQL 119

Query: 63  HELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTT 122
             L L+ N L      S   +  L+ L L++N++  +   A   L NL  L L+SN L  
Sbjct: 120 LSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRA 179

Query: 123 LPPDFLESWTHL 134
           +   + E   +L
Sbjct: 180 IDSRWFEMLPNL 191


>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
          Length = 713

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 73/290 (25%), Positives = 128/290 (44%), Gaps = 37/290 (12%)

Query: 24  IRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDG-NSLAAFPWASLLD 82
           + R+   A   +  L++L +  N +  + P  F N+  L EL L+    L +    +L++
Sbjct: 249 LARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVN 308

Query: 83  MPLLRTLDLHNN-KITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVSTPSGV 141
           +P L  LD+ NN +++ +   A  +L  +  L L++N L+ L    +ES  +L       
Sbjct: 309 LPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQE----- 363

Query: 142 LDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMT-CSEPERLTGILFQ- 199
                    +GL  NP  CDC    +I  +      +  ++P  T C+EP  L  +  + 
Sbjct: 364 ---------VGLHGNPIRCDC----VIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVRE 410

Query: 200 ---RAELEHCLKP-SVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVI 255
              R   +HCL   S  +    +  A G +++L C A   P P+I W     +P    + 
Sbjct: 411 VPFREMTDHCLPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWV----TPAGLRLT 466

Query: 256 QESPEEGVRWSI-----MSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTV 300
                 G R+ +     + L  +++++AG Y C A+NL G     V+V V
Sbjct: 467 PA--HAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVV 514



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 37/132 (28%), Positives = 58/132 (43%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQL 62
           +  +P  LP  T  L ++   I R+      YL  L  L ++ NS +      F+ L QL
Sbjct: 60  LTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQL 119

Query: 63  HELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTT 122
             L L+ N L      S   +  L+ L L++N++  +   A   L NL  L L+SN L  
Sbjct: 120 LSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRA 179

Query: 123 LPPDFLESWTHL 134
           +   + E   +L
Sbjct: 180 IDSRWFEMLPNL 191


>gi|38202222 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 71/230 (30%), Positives = 113/230 (49%), Gaps = 27/230 (11%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVAS--IDPSSFYNLK 60
           ++ +P  LP    +LR++   I  IS+ +   L  L+ L +  N + +  +    F+NL 
Sbjct: 166 LSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLV 225

Query: 61  QLHELRLDGNSLAAFPWASLLDMP--LLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSN 118
            L EL L  NSL A P    +++P   LR L L +N I  VP  A  YL+ L  LD+S+N
Sbjct: 226 NLTELSLVRNSLTAAP----VNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNN 281

Query: 119 RLTTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAI 178
            L+ L              P G+ D   +   L L++NPW+C C +  + +  + + P  
Sbjct: 282 NLSNL--------------PQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSL-PVK 326

Query: 179 VLLDPLMTCSEPERLTGILFQ--RAELEHCLKPSVMTSATKIMSALGSNV 226
           V +  LM C  PE++ G+  +   AEL  C K S + S  +I +A+ + V
Sbjct: 327 VNVRGLM-CQAPEKVRGMAIKDLNAELFDC-KDSGIVSTIQITTAIPNTV 374



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 29/95 (30%), Positives = 40/95 (42%), Gaps = 23/95 (24%)

Query: 53  PSSFYNLKQLHELRLDGNSLAAFP---------------------WASLLDMPLLRTLDL 91
           PS   NL ++  + L  NSL  FP                     + SL  +P L  L L
Sbjct: 76  PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHL 135

Query: 92  HNNKITSVPNE--ALRYLKNLAYLDLSSNRLTTLP 124
            +N +++V  E  A R    L  L LS N L+T+P
Sbjct: 136 DDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP 170


>gi|7019383 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 71/230 (30%), Positives = 113/230 (49%), Gaps = 27/230 (11%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVAS--IDPSSFYNLK 60
           ++ +P  LP    +LR++   I  IS+ +   L  L+ L +  N + +  +    F+NL 
Sbjct: 166 LSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLV 225

Query: 61  QLHELRLDGNSLAAFPWASLLDMP--LLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSN 118
            L EL L  NSL A P    +++P   LR L L +N I  VP  A  YL+ L  LD+S+N
Sbjct: 226 NLTELSLVRNSLTAAP----VNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNN 281

Query: 119 RLTTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAI 178
            L+ L              P G+ D   +   L L++NPW+C C +  + +  + + P  
Sbjct: 282 NLSNL--------------PQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSL-PVK 326

Query: 179 VLLDPLMTCSEPERLTGILFQ--RAELEHCLKPSVMTSATKIMSALGSNV 226
           V +  LM C  PE++ G+  +   AEL  C K S + S  +I +A+ + V
Sbjct: 327 VNVRGLM-CQAPEKVRGMAIKDLNAELFDC-KDSGIVSTIQITTAIPNTV 374



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 29/95 (30%), Positives = 40/95 (42%), Gaps = 23/95 (24%)

Query: 53  PSSFYNLKQLHELRLDGNSLAAFP---------------------WASLLDMPLLRTLDL 91
           PS   NL ++  + L  NSL  FP                     + SL  +P L  L L
Sbjct: 76  PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHL 135

Query: 92  HNNKITSVPNE--ALRYLKNLAYLDLSSNRLTTLP 124
            +N +++V  E  A R    L  L LS N L+T+P
Sbjct: 136 DDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIP 170


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 51/160 (31%), Positives = 79/160 (49%), Gaps = 14/160 (8%)

Query: 5   ELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHE 64
           E+P++LP  T  L ++   I  + A AF  +  L  L ++ NS++++ P +F+ L+ L  
Sbjct: 43  EIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGAFHGLQHLQV 102

Query: 65  LRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLP 124
           L L  NSL +        +P LR LDL +N I+ +P       +NL  L +  N+L  L 
Sbjct: 103 LNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAVQQNQLQQLD 162

Query: 125 PDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHI 164
              LES               PS  +L L+DN W C+CH+
Sbjct: 163 RALLES--------------MPSVRLLLLKDNLWKCNCHL 188


>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
           sapiens]
          Length = 592

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 75/326 (23%), Positives = 124/326 (38%), Gaps = 47/326 (14%)

Query: 16  KLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAF 75
           +L +E+  +  +S E+  +L  L  L + + ++AS++  +F  L  L  L +D   L   
Sbjct: 178 ELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEE 237

Query: 76  PWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHL- 134
             A  L    L +L + +  IT+VP  ALR+  +L  L+LS N ++T+P         L 
Sbjct: 238 VAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLR 297

Query: 135 ----------VSTPSGVLDLSPSRII-----------------------LGLQDNPWFCD 161
                     V  P   L L   R++                       L +  NP  CD
Sbjct: 298 ELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACD 357

Query: 162 CHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQRA------ELEHCLKPSVMTSA 215
           C +  +++  K ++        L  C+ P  + G   +        E   C KP +    
Sbjct: 358 CRLLWIVQRRKTLN----FDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERR 413

Query: 216 T-KIMSALGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGVRWSIMSLTGIS 274
             ++ +  G +V   C A G P P + W      PV  T         +    + +    
Sbjct: 414 LQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPV--TATSAGRARVLPGGTLEIQDAR 471

Query: 275 SKDAGDYKCKAKNLAGMSEAVVTVTV 300
            +D+G Y C A N  G      T+TV
Sbjct: 472 PQDSGTYTCVASNAGGNDTYFATLTV 497



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 34/118 (28%), Positives = 59/118 (50%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQL 62
           +  +P  +P +T  L + +  IR ++      L  L+ L ++ N++A ++P +F NL +L
Sbjct: 45  LTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRL 104

Query: 63  HELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 120
             LRL GN L   P      +  L  LDL  NK+  + +   + L +L  L++  N L
Sbjct: 105 RVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDL 162



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 34/110 (30%), Positives = 52/110 (47%)

Query: 14  TVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLA 73
           TV+ R      RR++A       E + L ++ N +  ++P     L  L EL L  N++A
Sbjct: 32  TVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIA 91

Query: 74  AFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTL 123
                +  ++P LR L L  N++  +P      L NL  LDLS N+L  L
Sbjct: 92  HVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVIL 141



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 7/106 (6%)

Query: 65  LRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLP 124
           L L  N +       L  +P L  LDL  N I  V   A   L  L  L L  N+L  +P
Sbjct: 59  LELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIP 118

Query: 125 PDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIEL 170
           P       +L      +LDLS +++++ L     F D H  + +E+
Sbjct: 119 PGVFTRLDNLT-----LLDLSENKLVILLDYT--FQDLHSLRRLEV 157



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 19/64 (29%), Positives = 40/64 (62%), Gaps = 3/64 (4%)

Query: 13  DTVKLR---IEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDG 69
           D V+LR   +   ++  +  +AF  L +++ L ++ N +++++ S+F+++  L  LR+DG
Sbjct: 292 DLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDG 351

Query: 70  NSLA 73
           N LA
Sbjct: 352 NPLA 355


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 55/197 (27%), Positives = 92/197 (46%), Gaps = 30/197 (15%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQL 62
           + E+PTNLP    ++R+E+  I+ I   AF    +L+ + ++ N ++ + P +F  L+ L
Sbjct: 291 LTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSL 350

Query: 63  HELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTT 122
           + L L GN +   P +    +  L+ L L+ NKI  +  +A + L NL  L L  N+L T
Sbjct: 351 NSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQT 410

Query: 123 LPPDFLESWTHLVSTPSGVLDLSPSRII--LGLQDNPWFCDCHISKMIELSKVVDPAIVL 180
           +                     SP R I  + L  NP+ CDCH+  + +         + 
Sbjct: 411 IAKG----------------TFSPLRAIQTMHLAQNPFICDCHLKWLAD--------YLH 446

Query: 181 LDPLMT----CSEPERL 193
            +P+ T    C+ P RL
Sbjct: 447 TNPIETSGARCTSPRRL 463



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 49/173 (28%), Positives = 81/173 (46%), Gaps = 10/173 (5%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQL 62
           +  +P N+P +T +L +    I RI+   F  L  L+ L +  N +++I+  +F +LK+L
Sbjct: 46  LRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKEL 105

Query: 63  HELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTT 122
             LRL+ N L  FP    L    L  LDL  N+I ++P +A R   ++  L L  N+++ 
Sbjct: 106 ERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISC 165

Query: 123 LPPD---FLESWTHLVSTPSGVLDLS-------PSRIILGLQDNPWFCDCHIS 165
           +       L     L    + +  LS       P      L  N  +CDCH++
Sbjct: 166 IEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLA 218



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 42/164 (25%), Positives = 76/164 (46%), Gaps = 15/164 (9%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEA-FYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61
           +N++P ++P  T +LR+       + A   F  L +L+ +  + N +  I+  +F     
Sbjct: 524 LNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASG 583

Query: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLT 121
           ++E+ L  N L          +  L+TL L +N+IT V N++   L ++  L L  N++T
Sbjct: 584 VNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQIT 643

Query: 122 TLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHIS 165
           T+ P              G  D   S   L L  NP+ C+C+++
Sbjct: 644 TVAP--------------GAFDTLHSLSTLNLLANPFNCNCYLA 673



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 34/115 (29%), Positives = 54/115 (46%), Gaps = 1/115 (0%)

Query: 6   LPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHEL 65
           LP  +P D  +L ++      +  E   Y   L  + ++ N ++++   SF N+ QL  L
Sbjct: 748 LPKGIPRDVTELYLDGNQFTLVPKELSNYK-HLTLIDLSNNRISTLSNQSFSNMTQLLTL 806

Query: 66  RLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 120
            L  N L   P  +   +  LR L LH N I+ VP  A   L  L++L + +N L
Sbjct: 807 ILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 861



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 35/115 (30%), Positives = 55/115 (47%), Gaps = 11/115 (9%)

Query: 60  KQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNR 119
           + + EL LDGN     P   L +   L  +DL NN+I+++ N++   +  L  L LS NR
Sbjct: 754 RDVTELYLDGNQFTLVP-KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNR 812

Query: 120 LTTLPP---DFLES-------WTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHI 164
           L  +PP   D L+S          +   P G  +   +   L +  NP +CDC++
Sbjct: 813 LRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNM 867


>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
           sapiens]
          Length = 660

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 61/196 (31%), Positives = 95/196 (48%), Gaps = 20/196 (10%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVAS--IDPSSFYNLK 60
           ++ +P  LPVD  +LR+++  I  IS  AF  L  L+ L V  N + +  I   +F +L 
Sbjct: 171 LSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLT 230

Query: 61  QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 120
           +L E  +  NSL+  P   L    L+R L L +N+I  +P  A   L+ L  LD+S+N+L
Sbjct: 231 KLKEFSIVRNSLS-HPPPDLPGTHLIR-LYLQDNQINHIPLTAFSNLRKLERLDISNNQL 288

Query: 121 TTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVL 180
             L                GV D   +   L  ++NPWFCDC I  + E  K +  ++ +
Sbjct: 289 RMLT--------------QGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNV 334

Query: 181 LDPLMTCSEPERLTGI 196
                 C  PE++ G+
Sbjct: 335 RG--FMCQGPEQVRGM 348



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 34/111 (30%), Positives = 53/111 (47%), Gaps = 18/111 (16%)

Query: 53  PSSFYNLKQLHELRLDGNSLAAFPWASLLDMPL-LRTLDLHNNKITSVPNEALRYLKNLA 111
           P+  +N++ +H + L GN L  FP    +++P  +R L L  N I ++   AL  L  L 
Sbjct: 81  PAELHNVQSVHTVYLYGNQLDEFP----MNLPKNVRVLHLQENNIQTISRAALAQLLKLE 136

Query: 112 YLDLSSNRLTTLPPD---FLE---------SWTHLVSTPSGV-LDLSPSRI 149
            L L  N ++T+  +   F E         S  HL S P G+ +DL   R+
Sbjct: 137 ELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRV 187


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 81/311 (26%), Positives = 121/311 (38%), Gaps = 28/311 (9%)

Query: 27  ISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLL 86
           IS  AF  LV L+YL +   ++  I   +   L +L EL L GN L      S   +  L
Sbjct: 198 ISEAAFEGLVNLRYLNLGMCNLKDIP--NLTALVRLEELELSGNRLDLIRPGSFQGLTSL 255

Query: 87  RTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVSTPSGVLDLSP 146
           R L L + ++ ++   A   LK+L  L+LS N L +LP D          TP   L+   
Sbjct: 256 RKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLF--------TPLHRLER-- 305

Query: 147 SRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQRAELEH- 205
               + L  NPW C+C +  +    K   P+         C  P  L G      +  H 
Sbjct: 306 ----VHLNHNPWHCNCDVLWLSWWLKETVPSNTTC--CARCHAPAGLKGRYIGELDQSHF 359

Query: 206 -CLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPV---NYTVIQESPEE 261
            C  P ++   T +    G    L+C  TG     + W   + + +   +Y V      +
Sbjct: 360 TCYAPVIVEPPTDLNVTEGMAAELKC-RTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHD 418

Query: 262 GVRWSIMSLTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSERTGDHPE 321
           G     ++ T ++ +D G Y C   N AG + A  T+ V  +         S   G    
Sbjct: 419 GT----LNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGGGPGGS 474

Query: 322 WDVQPGSGRST 332
             V  GSG  T
Sbjct: 475 GGVGGGSGGYT 485



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 38/114 (33%), Positives = 61/114 (53%)

Query: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61
           D+ E+P ++PV+T  L +++  I+ I  + F +L  L+ L ++ N V  I+  +F  L  
Sbjct: 76  DLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPS 135

Query: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDL 115
           L+ L L  N L   P  +   +  LR L L NN I S+P+ A   + +L  LDL
Sbjct: 136 LNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDL 189


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 56/193 (29%), Positives = 87/193 (45%), Gaps = 26/193 (13%)

Query: 5   ELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHE 64
           E+P NLP   V++R+E+  I+ I A AF    +L+ + ++ N ++ I P +F  LK L  
Sbjct: 300 EIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTS 359

Query: 65  LRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLP 124
           L L GN +          +  L+ L L+ NKI  +     + L+NL  L L  N+L T+ 
Sbjct: 360 LVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTI- 418

Query: 125 PDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPL 184
                          G+     S   L L  NP+ CDCH+  + +  +         +P+
Sbjct: 419 -------------SKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQD--------NPI 457

Query: 185 MT----CSEPERL 193
            T    CS P RL
Sbjct: 458 ETSGARCSSPRRL 470



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 51/175 (29%), Positives = 83/175 (47%), Gaps = 10/175 (5%)

Query: 1   MDMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLK 60
           + +  +P  +P +  +L +++  I RI+   F  L  L+ L +  N V+ I+  +F +LK
Sbjct: 50  LGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLK 109

Query: 61  QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 120
           QL  LRL+ N L   P       P L  LDL  N+I  +P +A R + ++  L L +N +
Sbjct: 110 QLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHI 169

Query: 121 TTLPPDF------LESWTHLVSTPSGVLDLS----PSRIILGLQDNPWFCDCHIS 165
           + +          LE  T   +  S +L  S    P    L L  N  +CDCH++
Sbjct: 170 SCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLA 224



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 43/161 (26%), Positives = 73/161 (45%), Gaps = 15/161 (9%)

Query: 6   LPTNLPVDTVKLRIEKTVIRRISAEA-FYYLVELQYLWVTYNSVASIDPSSFYNLKQLHE 64
           +P++LP     LR+    +  + A   F  L  L+ + ++ N +  +   +F     + E
Sbjct: 526 IPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQE 585

Query: 65  LRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLP 124
           L L GN L          +  L+TL L +N I  V N+    L ++  L L  NR+TT+ 
Sbjct: 586 LMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTIT 645

Query: 125 PDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHIS 165
           P    ++T LVS  +           + L  NP+ C+CH++
Sbjct: 646 PG---AFTTLVSLST-----------INLLSNPFNCNCHLA 672



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 38/122 (31%), Positives = 59/122 (48%), Gaps = 9/122 (7%)

Query: 3   MNELPTNLPVDTVKLRIE----KTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYN 58
           +  LP  +P D  +L +E      V R +SA     L++L     + NS++ +   +F N
Sbjct: 743 LRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDL-----SNNSISMLTNYTFSN 797

Query: 59  LKQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSN 118
           +  L  L L  N L   P  +   +  LR L LH N I+SVP  +   L +L++L L +N
Sbjct: 798 MSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTN 857

Query: 119 RL 120
            L
Sbjct: 858 PL 859



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 45/144 (31%), Positives = 59/144 (40%), Gaps = 19/144 (13%)

Query: 60  KQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNR 119
           K + EL L+GN L A P   L  +  L  +DL NN I+ + N     + +L+ L LS NR
Sbjct: 752 KDVTELYLEGNHLTAVP-RELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNR 810

Query: 120 LTTLPPDFLESWTHL----------VSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIE 169
           L  +P         L           S P G  +   S   L L  NP  CDC +  + E
Sbjct: 811 LRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSE 870

Query: 170 LSKV--VDPAIVLLDPLMTCSEPE 191
             K    +P I        CS PE
Sbjct: 871 WVKAGYKEPGIA------RCSSPE 888


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 52/204 (25%), Positives = 90/204 (44%), Gaps = 14/204 (6%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQL 62
           +  +P N+P +T +L +    I RI    F  L +L+ L +  N + +++  +F ++K+L
Sbjct: 52  LQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKEL 111

Query: 63  HELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTT 122
             LRL+ N L   P     +   L  LDL  N I ++P +A R   +L  L L  N+++ 
Sbjct: 112 ERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISC 171

Query: 123 LPPDFLESW----------THLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSK 172
           +      +            ++ + P    +  P      L  N  FCDCH++ + +  +
Sbjct: 172 IEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLR 231

Query: 173 VVDPAIVLLDPLMTCSEPERLTGI 196
              P I L      CS P  L G+
Sbjct: 232 -QRPTIGL---FTQCSGPASLRGL 251



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 51/195 (26%), Positives = 89/195 (45%), Gaps = 26/195 (13%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQL 62
           +  +P NLP    ++R+E   I+ I   AF    +L+ + ++ N +A I P +F  L+ L
Sbjct: 300 LTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSL 359

Query: 63  HELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTT 122
           + L L GN +   P      +  L+ L L+ NKI  +  +A + L+NL+ L L  N++ +
Sbjct: 360 NSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQS 419

Query: 123 LPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLD 182
           L      S   + +              L L  NP+ CDC++  + +  +         +
Sbjct: 420 LAKGTFTSLRAIQT--------------LHLAQNPFICDCNLKWLADFLRT--------N 457

Query: 183 PLMT----CSEPERL 193
           P+ T    C+ P RL
Sbjct: 458 PIETSGARCASPRRL 472



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 45/166 (27%), Positives = 77/166 (46%), Gaps = 15/166 (9%)

Query: 1   MDMNELPTNLPVDTVKLRIEKTVIRRISAEA-FYYLVELQYLWVTYNSVASIDPSSFYNL 59
           + + ++P  +P  T +LR+    I  + A   F  L  L+ + ++ N V+ I+  +F   
Sbjct: 529 LKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGA 588

Query: 60  KQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNR 119
             + EL L  N L +        +  LRTL L NN+I+ + N++   L+N+  L L  N+
Sbjct: 589 ASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQ 648

Query: 120 LTTLPPDFLESWTHLVSTPSGVLDLSPSRIILGLQDNPWFCDCHIS 165
           +TT+ P              G  D   S   L L  NP+ C+C ++
Sbjct: 649 ITTVSP--------------GAFDTLQSLSTLNLLANPFNCNCQLA 680



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 51/179 (28%), Positives = 73/179 (40%), Gaps = 21/179 (11%)

Query: 60  KQLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNR 119
           K + EL LDGN     P   L     L+ +DL NNKI+S+ N +   +  L  L LS N 
Sbjct: 761 KNVTELYLDGNQFTLVP-GQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNA 819

Query: 120 LTTLPPDFLESWTHL---------VST-PSGVLDLSPSRIILGLQDNPWFCDCHISKMIE 169
           L  +PP   +    L         +ST   G+     S   L +  NP +CDCH+  +  
Sbjct: 820 LQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSS 879

Query: 170 LSKV--VDPAIVLLDPLMTCSEPERLTG--ILFQRAELEHCLKPSVMTSATKIMSALGS 224
             K    +P I        C+ P+ + G  +L   A+   C  P  +    K    L S
Sbjct: 880 WVKTGYKEPGIA------RCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSS 932



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 32/120 (26%), Positives = 59/120 (49%), Gaps = 5/120 (4%)

Query: 3   MNELPTNLPVDTVKLRIEKTVIRRISAE--AFYYLVELQYLWVTYNSVASIDPSSFYNLK 60
           +  LP  +P +  +L ++      +  +   F YL   Q + ++ N ++S+  SSF N+ 
Sbjct: 752 LRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYL---QLVDLSNNKISSLSNSSFTNMS 808

Query: 61  QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRL 120
           QL  L L  N+L   P  +   +  LR L LH N I+++       + +L++L + +N L
Sbjct: 809 QLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 85/365 (23%), Positives = 141/365 (38%), Gaps = 33/365 (9%)

Query: 27  ISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQLHELRLDGNSLAAFPWASLLDMPLL 86
           IS  AF  L  L+YL +   ++  I   +   L +L EL L GN L+A    S   +  L
Sbjct: 188 ISEGAFEGLSNLRYLNLAMCNLREIP--NLTPLIKLDELDLSGNHLSAIRPGSFQGLMHL 245

Query: 87  RTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVSTPSGVLDLSP 146
           + L +  ++I  +   A   L++L  ++L+ N LT LP D      HL            
Sbjct: 246 QKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLER---------- 295

Query: 147 SRIILGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQRAELEH- 205
               + L  NPW C+C I  +    K + P+         C+ P  L G      +  + 
Sbjct: 296 ----IHLHHNPWNCNCDILWLSWWIKDMAPSNTAC--CARCNTPPNLKGRYIGELDQNYF 349

Query: 206 -CLKPSVMTSATKIMSALGSNVLLRCDATGFPTPQITWTRSDSSPVNYTVIQESPEEGVR 264
            C  P ++     +    G    L+C A+   T  ++W   + + + +   +      VR
Sbjct: 350 TCYAPVIVEPPADLNVTEGMAAELKCRASTSLT-SVSWITPNGTVMTHGAYK------VR 402

Query: 265 WSIMS-----LTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSERTGDH 319
            +++S      T ++ +D G Y C   N  G + A  T+ V   TTTP     S  T + 
Sbjct: 403 IAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPF-SYFSTVTVET 461

Query: 320 PEWDVQPGSGRSTSVSSASSYLWSSSFSPTSSFSASTLSPPSTASFSLSPFSSSTVSSTT 379
            E           +V       W ++   TS    ST S   T +  ++  +S       
Sbjct: 462 MEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDE 521

Query: 380 TLSTS 384
            + T+
Sbjct: 522 VMKTT 526



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 37/134 (27%), Positives = 67/134 (50%), Gaps = 1/134 (0%)

Query: 2   DMNELPTNLPVDTVKLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLKQ 61
           ++ E+P  +  +T  L + +  I+ I   +F +L  L+ L ++ N + +I+  +F  L  
Sbjct: 66  NLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLAN 125

Query: 62  LHELRLDGNSLAAFPWASLLDMPLLRTLDLHNNKITSVPNEALRYLKNLAYLDLSS-NRL 120
           L+ L L  N L   P  + + +  L+ L L NN I S+P+ A   + +L  LDL    RL
Sbjct: 126 LNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRL 185

Query: 121 TTLPPDFLESWTHL 134
           + +     E  ++L
Sbjct: 186 SYISEGAFEGLSNL 199



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 25/94 (26%), Positives = 47/94 (50%), Gaps = 1/94 (1%)

Query: 2   DMNELPTNLPVDTV-KLRIEKTVIRRISAEAFYYLVELQYLWVTYNSVASIDPSSFYNLK 60
           ++ E+P   P+  + +L +    +  I   +F  L+ LQ LW+  + +  I+ ++F NL+
Sbjct: 208 NLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQ 267

Query: 61  QLHELRLDGNSLAAFPWASLLDMPLLRTLDLHNN 94
            L E+ L  N+L   P      +  L  + LH+N
Sbjct: 268 SLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.129    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,345,034
Number of Sequences: 37866
Number of extensions: 1064222
Number of successful extensions: 10587
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 389
Number of HSP's successfully gapped in prelim test: 355
Number of HSP's that attempted gapping in prelim test: 4578
Number of HSP's gapped (non-prelim): 3875
length of query: 634
length of database: 18,247,518
effective HSP length: 108
effective length of query: 526
effective length of database: 14,157,990
effective search space: 7447102740
effective search space used: 7447102740
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.