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Search of human proteins with 190885497
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
(532 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 1077 0.0
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 993 0.0
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 992 0.0
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 556 e-158
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 555 e-158
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 122 1e-27
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 107 3e-23
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 107 3e-23
gi|39930351 dynamin binding protein [Homo sapiens] 94 4e-19
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 91 3e-18
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 91 3e-18
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 88 2e-17
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 86 1e-16
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 86 1e-16
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 83 5e-16
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 83 5e-16
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 82 9e-16
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 82 9e-16
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 82 9e-16
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 82 9e-16
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 82 2e-15
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 82 2e-15
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 82 2e-15
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 81 2e-15
gi|21735572 epithelial cell transforming sequence 2 oncogene pro... 76 7e-14
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 75 1e-13
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 75 1e-13
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens] 74 4e-13
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 72 1e-12
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 72 1e-12
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 1077 bits (2784), Expect = 0.0
Identities = 532/532 (100%), Positives = 532/532 (100%)
Query: 1 MIEVCHHNWLLWLCPSKFGIFMCCLASTTGQMELRRTREPSNKRVKPLSRVTSLANLIPP 60
MIEVCHHNWLLWLCPSKFGIFMCCLASTTGQMELRRTREPSNKRVKPLSRVTSLANLIPP
Sbjct: 1 MIEVCHHNWLLWLCPSKFGIFMCCLASTTGQMELRRTREPSNKRVKPLSRVTSLANLIPP 60
Query: 61 VKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQ 120
VKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQ
Sbjct: 61 VKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQ 120
Query: 121 MLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLI 180
MLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLI
Sbjct: 121 MLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLI 180
Query: 181 PLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRV 240
PLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRV
Sbjct: 181 PLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRV 240
Query: 241 QDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINII 300
QDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINII
Sbjct: 241 QDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINII 300
Query: 301 QGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLF 360
QGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLF
Sbjct: 301 QGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLF 360
Query: 361 QEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFF 420
QEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFF
Sbjct: 361 QEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFF 420
Query: 421 RVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGS 480
RVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGS
Sbjct: 421 RVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGS 480
Query: 481 RELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV 532
RELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV
Sbjct: 481 RELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV 532
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 993 bits (2566), Expect = 0.0
Identities = 496/510 (97%), Positives = 497/510 (97%)
Query: 23 CCLASTTGQMELRRTREPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSE 82
C L + EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSE
Sbjct: 17 CSLELPPASGPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSE 76
Query: 83 SRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEED 142
SRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEED
Sbjct: 77 SRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEED 136
Query: 143 LIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEH 202
LIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEH
Sbjct: 137 LIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEH 196
Query: 203 VGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFL 262
VGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFL
Sbjct: 197 VGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFL 256
Query: 263 DIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKER 322
DIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKER
Sbjct: 257 DIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKER 316
Query: 323 LLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYR 382
LLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYR
Sbjct: 317 LLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYR 376
Query: 383 QPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFN 442
QPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFN
Sbjct: 377 QPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFN 436
Query: 443 KQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCS 502
KQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCS
Sbjct: 437 KQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCS 496
Query: 503 MDTSEVSLDCERMEQTDSSCGNSRHGESNV 532
MDTSEVSLDCERMEQTDSSCGNSRHGESNV
Sbjct: 497 MDTSEVSLDCERMEQTDSSCGNSRHGESNV 526
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
[Homo sapiens]
Length = 558
Score = 992 bits (2564), Expect = 0.0
Identities = 494/494 (100%), Positives = 494/494 (100%)
Query: 39 EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAA 98
EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAA
Sbjct: 65 EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAA 124
Query: 99 PSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM 158
PSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM
Sbjct: 125 PSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM 184
Query: 159 LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD 218
LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD
Sbjct: 185 LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD 244
Query: 219 SYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 278
SYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE
Sbjct: 245 SYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 304
Query: 279 ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS 338
ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS
Sbjct: 305 ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS 364
Query: 339 RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDG 398
RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDG
Sbjct: 365 RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDG 424
Query: 399 EVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVL 458
EVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVL
Sbjct: 425 EVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVL 484
Query: 459 CAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQT 518
CAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQT
Sbjct: 485 CAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQT 544
Query: 519 DSSCGNSRHGESNV 532
DSSCGNSRHGESNV
Sbjct: 545 DSSCGNSRHGESNV 558
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
[Homo sapiens]
Length = 542
Score = 556 bits (1433), Expect = e-158
Identities = 269/419 (64%), Positives = 343/419 (81%), Gaps = 1/419 (0%)
Query: 35 RRTREPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWS 94
R EPSNKRV+PL+RVTSLANLI PV+ ++RF QT+Q S + R + R A + S
Sbjct: 28 REQEEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQ-SFTLRGDHRSPASAQKFSS 86
Query: 95 RNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAY 154
R+ P+ KRR S LWSE D+ + + LT++EI+RQEAI+E+S+GE+DLIEDLKLA+KAY
Sbjct: 87 RSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAY 146
Query: 155 HDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCL 214
HDPMLKLSIM+E+EL IFG LDS IPLHE+LL+++ + KPDG+ E +G ILV WLP L
Sbjct: 147 HDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRL 206
Query: 215 SSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPL 274
++Y YCSNQ+AAKALLD KKQD RVQDFLQRCLESPFSRKLDLW+FLDIPRSRLVKYPL
Sbjct: 207 NAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPL 266
Query: 275 LLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSL 334
LL+EIL+HTP ++PD Q LE+AI IIQG++++IN K GESEC+YY ++L YL+E Q+D
Sbjct: 267 LLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPR 326
Query: 335 IDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLED 394
I++S+VL CHGEL++ G KL++FLFQ++LV+TR VT NE+ YQ+YRQPIPV++L+LED
Sbjct: 327 IEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLED 386
Query: 395 LQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQA 453
LQDG+VR+GGS RGAFSN+E+ KN FR+ F + S +Q+H+LQAND F+KQQW NCIR A
Sbjct: 387 LQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAA 445
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
Length = 596
Score = 555 bits (1431), Expect = e-158
Identities = 268/416 (64%), Positives = 343/416 (82%), Gaps = 1/416 (0%)
Query: 38 REPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNA 97
+EPSNKRV+PL+RVTSLANLI PV+ ++RF QT+Q S + R + R A + SR+
Sbjct: 85 KEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQ-SFTLRGDHRSPASAQKFSSRST 143
Query: 98 APSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDP 157
P+ KRR S LWSE D+ + + LT++EI+RQEAI+E+S+GE+DLIEDLKLA+KAYHDP
Sbjct: 144 VPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDP 203
Query: 158 MLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSY 217
MLKLSIM+E+EL IFG LDS IPLHE+LL+++ + KPDG+ E +G ILV WLP L++Y
Sbjct: 204 MLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAY 263
Query: 218 DSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLR 277
YCSNQ+AAKALLD KKQD RVQDFLQRCLESPFSRKLDLW+FLDIPRSRLVKYPLLL+
Sbjct: 264 RGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLK 323
Query: 278 EILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDS 337
EIL+HTP ++PD Q LE+AI IIQG++++IN K GESEC+YY ++L YL+E Q+D I++
Sbjct: 324 EILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEA 383
Query: 338 SRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQD 397
S+VL CHGEL++ G KL++FLFQ++LV+TR VT NE+ YQ+YRQPIPV++L+LEDLQD
Sbjct: 384 SKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQD 443
Query: 398 GEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQA 453
G+VR+GGS RGAFSN+E+ KN FR+ F + S +Q+H+LQAND F+KQQW NCIR A
Sbjct: 444 GDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAA 499
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 122 bits (305), Expect = 1e-27
Identities = 90/327 (27%), Positives = 162/327 (49%), Gaps = 34/327 (10%)
Query: 96 NAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYH 155
N +T S+ W D+ + MLT E KRQ I EL EE+ + DL+L + +
Sbjct: 1207 NYVKLTTDMDPSQQWCS--DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQ 1264
Query: 156 DPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGS---TEHVGPILVGWLP 212
P+++ ++TE+E+ IF LI + +LL LR +K G + +G IL LP
Sbjct: 1265 KPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLP 1324
Query: 213 CLSSYDSYCSNQVAAKALLDHKKQDHR-VQDFLQRCLESPFSRKLDLWNFLDIPRSRLVK 271
+ Y +CS Q+ AL+ K + ++F++R P + + L +F+ P R+ +
Sbjct: 1325 HMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTR 1384
Query: 272 YPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLE---- 327
YPL+++ IL +TP ++PD HL+ A+ + + +++N E E +RL +++
Sbjct: 1385 YPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKE---NSDRLEWIQAHVQ 1441
Query: 328 -EGQKDSLIDSSRVLCC-------HGEL-KNNRGVKLHVFLFQEVLVIT----------- 367
EG + L+ +S C G+L K +L+ FLF + L++T
Sbjct: 1442 CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGT 1501
Query: 368 -RAVTHNEQLCYQLYRQPIPVKDLLLE 393
+ + L Y++Y+ PI + ++L++
Sbjct: 1502 DKVFSPKSNLQYKMYKTPIFLNEVLVK 1528
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 107 bits (267), Expect = 3e-23
Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)
Query: 126 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 185
E KRQ I EL Q EE + DL+L + + M + +TE E+ IF LI + +
Sbjct: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239
Query: 186 LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 241
LL LR +K G + +G IL L + +Y +CS Q+ ALL K +D +
Sbjct: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1299
Query: 242 DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 301
+FL++ P + + L +FL P R+ +YPLL+R IL +TP + D L+ A+ +
Sbjct: 1300 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1359
Query: 302 GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 348
+ +++N E E +RL +++ EG + LI +S R L G+L K
Sbjct: 1360 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1416
Query: 349 NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 393
+LH FLF + L++T V + +E+L +++Y+ PI + ++L++
Sbjct: 1417 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1474
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 107 bits (267), Expect = 3e-23
Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)
Query: 126 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 185
E KRQ I EL Q EE + DL+L + + M + +TE E+ IF LI + +
Sbjct: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266
Query: 186 LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 241
LL LR +K G + +G IL L + +Y +CS Q+ ALL K +D +
Sbjct: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1326
Query: 242 DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 301
+FL++ P + + L +FL P R+ +YPLL+R IL +TP + D L+ A+ +
Sbjct: 1327 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1386
Query: 302 GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 348
+ +++N E E +RL +++ EG + LI +S R L G+L K
Sbjct: 1387 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1443
Query: 349 NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 393
+LH FLF + L++T V + +E+L +++Y+ PI + ++L++
Sbjct: 1444 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1501
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 93.6 bits (231), Expect = 4e-19
Identities = 71/239 (29%), Positives = 118/239 (49%), Gaps = 23/239 (9%)
Query: 128 KRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELL 187
KR + I EL Q E D I DL++ + PM + + + +FG + +I + ++LL
Sbjct: 784 KRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQV-PNIDFEGLFGNMQMVIKVSKQLL 842
Query: 188 SQLRDVRKPDGSTEHVGPILVGWLPCLS-SYDSYCSNQVAAKALLDHKKQDHRVQDFLQR 246
+ L ++ VGP+ +G L +Y YC N A ALL+ ++D ++Q LQ
Sbjct: 843 AALE-------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQD 895
Query: 247 CL--------ESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAIN 298
L E + ++L +FL P R+++YPLLL E+L TP +PD+ L A+
Sbjct: 896 SLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVL 955
Query: 299 IIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHV 357
++ I IN E + K+ +L +G +DSL++ L H +K + V H+
Sbjct: 956 AVKEINVNIN------EYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHL 1008
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/520 (23%), Positives = 214/520 (41%), Gaps = 65/520 (12%)
Query: 27 STTGQMELRRTREPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRP- 85
S G+ E++R+R+ N + R S ++ +AT L + + + S+S RS P
Sbjct: 654 SLKGREEMKRSRKAEN-----VPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPT 708
Query: 86 ---------------------DILAPRPWSRNAAPSST--KRRDSKLWSETFDVCVNQML 122
D L P + S D++ W T V L
Sbjct: 709 PPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGL 768
Query: 123 TSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPL 182
T +EI RQE I EL E + L++ ++ M K ++M +EL ++F L LI +
Sbjct: 769 TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 828
Query: 183 HEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD------SYCSNQVAAKALLDHK-K 235
H ++ +R+ + + +++ + + +CS Q A L+ K +
Sbjct: 829 HNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 888
Query: 236 QDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEE 295
++ R Q F+Q P R+L L + + RL KYPLLL I++HT + + L
Sbjct: 889 KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 948
Query: 296 AINIIQGIVAEINTKTGESECRY----YKERL--LYLEEGQK------DSLIDSSRVLCC 343
A + + I+ +N ++E R+ Y++RL LE SL ++R +
Sbjct: 949 ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 1008
Query: 344 HGEL----KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGE 399
G L ++ + LHV L +++LV+ + +E+L + + + V +
Sbjct: 1009 EGPLTWRISKDKTLDLHVLLLEDLLVLLQ--KQDEKLLLKCHSK-TAVGSSDSKQTFSPV 1065
Query: 400 VRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLC 459
++L L + + ++R FF + Q + L A + +K W+ + +A
Sbjct: 1066 LKLNAVLIRSVATDKRA--FFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATR 1123
Query: 460 AAGQAGVLDSEGSFLNPTTGSRE--LQGETKLE-QMDQSD 496
G A + P G RE QG T ++D SD
Sbjct: 1124 HPGAAPM-----PVHPPPPGPREPAQQGPTPSRVELDDSD 1158
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 90.9 bits (224), Expect = 3e-18
Identities = 120/520 (23%), Positives = 214/520 (41%), Gaps = 65/520 (12%)
Query: 27 STTGQMELRRTREPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRP- 85
S G+ E++R+R+ N + R S ++ +AT L + + + S+S RS P
Sbjct: 614 SLKGREEMKRSRKAEN-----VPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPT 668
Query: 86 ---------------------DILAPRPWSRNAAPSST--KRRDSKLWSETFDVCVNQML 122
D L P + S D++ W T V L
Sbjct: 669 PPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGL 728
Query: 123 TSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPL 182
T +EI RQE I EL E + L++ ++ M K ++M +EL ++F L LI +
Sbjct: 729 TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 788
Query: 183 HEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD------SYCSNQVAAKALLDHK-K 235
H ++ +R+ + + +++ + + +CS Q A L+ K +
Sbjct: 789 HNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 848
Query: 236 QDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEE 295
++ R Q F+Q P R+L L + + RL KYPLLL I++HT + + L
Sbjct: 849 KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 908
Query: 296 AINIIQGIVAEINTKTGESECRY----YKERL--LYLEEGQK------DSLIDSSRVLCC 343
A + + I+ +N ++E R+ Y++RL LE SL ++R +
Sbjct: 909 ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 968
Query: 344 HGEL----KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGE 399
G L ++ + LHV L +++LV+ + +E+L + + + V +
Sbjct: 969 EGPLTWRISKDKTLDLHVLLLEDLLVLLQ--KQDEKLLLKCHSK-TAVGSSDSKQTFSPV 1025
Query: 400 VRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLC 459
++L L + + ++R FF + Q + L A + +K W+ + +A
Sbjct: 1026 LKLNAVLIRSVATDKRA--FFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATR 1083
Query: 460 AAGQAGVLDSEGSFLNPTTGSRE--LQGETKLE-QMDQSD 496
G A + P G RE QG T ++D SD
Sbjct: 1084 HPGAAPM-----PVHPPPPGPREPAQQGPTPSRVELDDSD 1118
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 88.2 bits (217), Expect = 2e-17
Identities = 78/280 (27%), Positives = 137/280 (48%), Gaps = 28/280 (10%)
Query: 126 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 185
EIKRQE I EL E + LK+ + ++ + + I++ EL +IF L+ ++ LH
Sbjct: 785 EIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIG 844
Query: 186 LLSQLRDVRKPDGST--EHVGPILVGWL------PCLSSYDSYCSNQ-VAAKALLDHKKQ 236
L Q++ VRK + ++ + +G L+ W + ++CSNQ A + + +K+
Sbjct: 845 LNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKK 904
Query: 237 DHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEA 296
D R Q F+Q +P R+L L + + RL KYPLLL I ++T +++ +++A
Sbjct: 905 DSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPT-EREKVKKA 963
Query: 297 INIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLH 356
+ + I+ +N E+E K+RL E + L SS L + ++ R + L
Sbjct: 964 ADHCRQILNYVNQAVKEAE---NKQRL----EDYQRRLDTSSLKLSEYPNVEELRNLDL- 1015
Query: 357 VFLFQEVLVITRAVTHNEQLCYQLYR-QPIPVKDLLLEDL 395
R + H L +++ R + I + LLLED+
Sbjct: 1016 ---------TKRKMIHEGPLVWKVNRDKTIDLYTLLLEDI 1046
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform
b [Homo sapiens]
Length = 1173
Score = 85.5 bits (210), Expect = 1e-16
Identities = 63/269 (23%), Positives = 125/269 (46%), Gaps = 24/269 (8%)
Query: 68 RFSQTLQRSISFRSESRPDILAPRPWS---RNAAPSSTKRRDSKLWSETFDVCVNQMLTS 124
+F QT S+S S + I P++ R+ S +++ WS D +
Sbjct: 196 KFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKR 255
Query: 125 KEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHE 184
+ +KRQ+ ++EL Q E + LK+ K Y + + + + + ++F D L+ H
Sbjct: 256 EVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHS 315
Query: 185 ELLSQLRDVRKP---DGSTEH-----VGPILVGWLP------CLSSYDSYCSNQVAA--- 227
L++L++ R+ +GS + +G +LV Y +CS A
Sbjct: 316 HFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSH 375
Query: 228 -KALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPND 286
K LL +Q+ + Q+ +++ R+L + + + R+ KYP+L+ I+++T
Sbjct: 376 YKLLL---QQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAG 432
Query: 287 NPDQQHLEEAINIIQGIVAEINTKTGESE 315
D + L +A+N+I+ I+++++ K E E
Sbjct: 433 TEDYEDLTQALNLIKDIISQVDAKVSECE 461
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 85.5 bits (210), Expect = 1e-16
Identities = 63/269 (23%), Positives = 125/269 (46%), Gaps = 24/269 (8%)
Query: 68 RFSQTLQRSISFRSESRPDILAPRPWS---RNAAPSSTKRRDSKLWSETFDVCVNQMLTS 124
+F QT S+S S + I P++ R+ S +++ WS D +
Sbjct: 38 KFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKR 97
Query: 125 KEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHE 184
+ +KRQ+ ++EL Q E + LK+ K Y + + + + + ++F D L+ H
Sbjct: 98 EVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHS 157
Query: 185 ELLSQLRDVRKP---DGSTEH-----VGPILVGWLP------CLSSYDSYCSNQVAA--- 227
L++L++ R+ +GS + +G +LV Y +CS A
Sbjct: 158 HFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSH 217
Query: 228 -KALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPND 286
K LL +Q+ + Q+ +++ R+L + + + R+ KYP+L+ I+++T
Sbjct: 218 YKLLL---QQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAG 274
Query: 287 NPDQQHLEEAINIIQGIVAEINTKTGESE 315
D + L +A+N+I+ I+++++ K E E
Sbjct: 275 TEDYEDLTQALNLIKDIISQVDAKVSECE 303
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 83.2 bits (204), Expect = 5e-16
Identities = 82/350 (23%), Positives = 156/350 (44%), Gaps = 47/350 (13%)
Query: 135 ELSQGEEDLIEDLKLAKKAYHDPMLKLSI------MTEQELNQIFGTLDSLIPLHEELLS 188
EL + E D + L+ A+ M + + +TE+ + +F ++ ++ +H+E L
Sbjct: 30 ELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLK 89
Query: 189 QLRDVRKPD-GSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRC 247
+ + P+ + + VG + + YD YCSN A+ LL + ++ FL C
Sbjct: 90 VVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNC 149
Query: 248 LESPFSRKLD--LWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVA 305
+ + D L +L P R+ KYPL+L+E+L+ TP + D + EA+ ++ + +
Sbjct: 150 MLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCS 209
Query: 306 EINTKTGESECRYYKERLLYLEEGQK-------DSLIDS-SRVLCCHGELKNNRG-VKLH 356
IN E + E+L LEE Q ++ D+ + +L C LK + G ++
Sbjct: 210 NIN------EAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQER 263
Query: 357 V-FLFQEVLVI----------TRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGS 405
V FLF +LV ++A T + L+R I + + +E++ DG
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHR---YLFRGRINTEVMEVENVDDGTADF--- 317
Query: 406 LRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKE 455
S+ + N +++ N ++++ A K +W I + +E
Sbjct: 318 ----HSSGHIVVNGWKI--HNTAKNKWFVCMAKTPEEKHEWFEAILKERE 361
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 83.2 bits (204), Expect = 5e-16
Identities = 82/350 (23%), Positives = 156/350 (44%), Gaps = 47/350 (13%)
Query: 135 ELSQGEEDLIEDLKLAKKAYHDPMLKLSI------MTEQELNQIFGTLDSLIPLHEELLS 188
EL + E D + L+ A+ M + + +TE+ + +F ++ ++ +H+E L
Sbjct: 30 ELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLK 89
Query: 189 QLRDVRKPD-GSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRC 247
+ + P+ + + VG + + YD YCSN A+ LL + ++ FL C
Sbjct: 90 VVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNC 149
Query: 248 LESPFSRKLD--LWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVA 305
+ + D L +L P R+ KYPL+L+E+L+ TP + D + EA+ ++ + +
Sbjct: 150 MLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCS 209
Query: 306 EINTKTGESECRYYKERLLYLEEGQK-------DSLIDS-SRVLCCHGELKNNRG-VKLH 356
IN E + E+L LEE Q ++ D+ + +L C LK + G ++
Sbjct: 210 NIN------EAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQER 263
Query: 357 V-FLFQEVLVI----------TRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGS 405
V FLF +LV ++A T + L+R I + + +E++ DG
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHR---YLFRGRINTEVMEVENVDDGTADF--- 317
Query: 406 LRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKE 455
S+ + N +++ N ++++ A K +W I + +E
Sbjct: 318 ----HSSGHIVVNGWKI--HNTAKNKWFVCMAKTPEEKHEWFEAILKERE 361
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 82.4 bits (202), Expect = 9e-16
Identities = 71/311 (22%), Positives = 142/311 (45%), Gaps = 28/311 (9%)
Query: 164 MTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEH-VGPILVGWLPCLSSYDSYCS 222
+TE+ + +F ++ ++ +H++ L+ L P+ ++H +G + + + Y+ YCS
Sbjct: 91 LTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCS 150
Query: 223 NQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLD--LWNFLDIPRSRLVKYPLLLREIL 280
N A LL + V+ FL C+ + D L +L P R+ KYPLLL+E+
Sbjct: 151 NHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELA 210
Query: 281 RHTPNDNPDQQHLEEAINIIQGIVAEIN-TKTGESECRYYKERLLYLEEGQKDSLIDSSR 339
+ TP +PD ++ A+ ++ + + IN TK + ++ ++E + +L D
Sbjct: 211 KRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICT 270
Query: 340 VLCCHGELKNNRGVKLH---VFLFQEVLVITR---AVTHNEQLCYQ---------LYRQP 384
L G L + FLF +LV + VT +++ + ++R
Sbjct: 271 QLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGR 330
Query: 385 IPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQ 444
I + + +E+++DG SN + N +++ N ++++ A KQ
Sbjct: 331 INTEVMEVENVEDGTA-------DYHSNGYTVTNGWKI--HNTAKNKWFVCMAKTAEEKQ 381
Query: 445 QWLNCIRQAKE 455
+WL+ I + +E
Sbjct: 382 KWLDAIIRERE 392
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 82.4 bits (202), Expect = 9e-16
Identities = 89/372 (23%), Positives = 157/372 (42%), Gaps = 41/372 (11%)
Query: 110 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQEL 169
W E L ++KRQE I EL E + L++ + PM + +EL
Sbjct: 413 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 472
Query: 170 NQIFGTLDSLIPLHEELLSQLRDVRKPDG-STEHVGPILV--------GWLPCLSSYDSY 220
IF +LD LI +H L +L R+ G E +G +L+ W +SS +
Sbjct: 473 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 530
Query: 221 CSNQ-VAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREI 279
CS Q A + L +++D R F+Q P R+L L + + RL KYPLLL+ I
Sbjct: 531 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 590
Query: 280 LRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESE----CRYYKER--LLYLEEGQKDS 333
++T + +++ +E A + I+ +N + E + Y+ R L +L +
Sbjct: 591 GQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPM 649
Query: 334 L-----IDSSRVLCCH-----GELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQ 383
L +D ++ H + ++ V++HV L ++L++ + +E+L + + +
Sbjct: 650 LSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQ--RQDERLLLKSHSR 707
Query: 384 PIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERI---KNFFRVSFKNGSQSQTHSLQANDT 440
L DG+ L LR + + F V F ++Q + L A
Sbjct: 708 -------TLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTV 760
Query: 441 FNKQQWLNCIRQ 452
++ W I +
Sbjct: 761 SERKNWCALITE 772
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 82.4 bits (202), Expect = 9e-16
Identities = 89/372 (23%), Positives = 157/372 (42%), Gaps = 41/372 (11%)
Query: 110 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQEL 169
W E L ++KRQE I EL E + L++ + PM + +EL
Sbjct: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424
Query: 170 NQIFGTLDSLIPLHEELLSQLRDVRKPDG-STEHVGPILV--------GWLPCLSSYDSY 220
IF +LD LI +H L +L R+ G E +G +L+ W +SS +
Sbjct: 425 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 482
Query: 221 CSNQ-VAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREI 279
CS Q A + L +++D R F+Q P R+L L + + RL KYPLLL+ I
Sbjct: 483 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 542
Query: 280 LRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESE----CRYYKER--LLYLEEGQKDS 333
++T + +++ +E A + I+ +N + E + Y+ R L +L +
Sbjct: 543 GQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPM 601
Query: 334 L-----IDSSRVLCCH-----GELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQ 383
L +D ++ H + ++ V++HV L ++L++ + +E+L + + +
Sbjct: 602 LSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQ--RQDERLLLKSHSR 659
Query: 384 PIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERI---KNFFRVSFKNGSQSQTHSLQANDT 440
L DG+ L LR + + F V F ++Q + L A
Sbjct: 660 -------TLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTV 712
Query: 441 FNKQQWLNCIRQ 452
++ W I +
Sbjct: 713 SERKNWCALITE 724
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 82.4 bits (202), Expect = 9e-16
Identities = 89/372 (23%), Positives = 157/372 (42%), Gaps = 41/372 (11%)
Query: 110 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQEL 169
W E L ++KRQE I EL E + L++ + PM + +EL
Sbjct: 398 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 457
Query: 170 NQIFGTLDSLIPLHEELLSQLRDVRKPDG-STEHVGPILV--------GWLPCLSSYDSY 220
IF +LD LI +H L +L R+ G E +G +L+ W +SS +
Sbjct: 458 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 515
Query: 221 CSNQ-VAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREI 279
CS Q A + L +++D R F+Q P R+L L + + RL KYPLLL+ I
Sbjct: 516 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 575
Query: 280 LRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESE----CRYYKER--LLYLEEGQKDS 333
++T + +++ +E A + I+ +N + E + Y+ R L +L +
Sbjct: 576 GQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPM 634
Query: 334 L-----IDSSRVLCCH-----GELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQ 383
L +D ++ H + ++ V++HV L ++L++ + +E+L + + +
Sbjct: 635 LSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQ--RQDERLLLKSHSR 692
Query: 384 PIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERI---KNFFRVSFKNGSQSQTHSLQANDT 440
L DG+ L LR + + F V F ++Q + L A
Sbjct: 693 -------TLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTV 745
Query: 441 FNKQQWLNCIRQ 452
++ W I +
Sbjct: 746 SERKNWCALITE 757
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 81.6 bits (200), Expect = 2e-15
Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)
Query: 102 TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 161
+K+ +++ WS D + +KRQE I+EL Q E + LK+ Y M+
Sbjct: 1972 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2031
Query: 162 SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 212
+ +Q + ++F LD LI +H + ++ + +K D S ++ +G +LV
Sbjct: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2091
Query: 213 -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 266
+Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 2092 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2151
Query: 267 SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 326
R+ KYP+L + IL+ T ++ +Q+ L +++++++ ++ +++K E + + +Y
Sbjct: 2152 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 2210
Query: 327 EEGQKDSLIDSSRVLCCHGELKNNRGVK 354
+ K + S + +LK + V+
Sbjct: 2211 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 2238
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 81.6 bits (200), Expect = 2e-15
Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)
Query: 102 TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 161
+K+ +++ WS D + +KRQE I+EL Q E + LK+ Y M+
Sbjct: 213 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 272
Query: 162 SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 212
+ +Q + ++F LD LI +H + ++ + +K D S ++ +G +LV
Sbjct: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 332
Query: 213 -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 266
+Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 333 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 392
Query: 267 SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 326
R+ KYP+L + IL+ T ++ +Q+ L +++++++ ++ +++K E + + +Y
Sbjct: 393 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 451
Query: 327 EEGQKDSLIDSSRVLCCHGELKNNRGVK 354
+ K + S + +LK + V+
Sbjct: 452 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 479
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 81.6 bits (200), Expect = 2e-15
Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)
Query: 102 TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 161
+K+ +++ WS D + +KRQE I+EL Q E + LK+ Y M+
Sbjct: 1968 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2027
Query: 162 SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 212
+ +Q + ++F LD LI +H + ++ + +K D S ++ +G +LV
Sbjct: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2087
Query: 213 -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 266
+Y +C + + D +D R Q F+++ + S R+L + + +
Sbjct: 2088 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2147
Query: 267 SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 326
R+ KYP+L + IL+ T ++ +Q+ L +++++++ ++ +++K E + + +Y
Sbjct: 2148 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 2206
Query: 327 EEGQKDSLIDSSRVLCCHGELKNNRGVK 354
+ K + S + +LK + V+
Sbjct: 2207 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 2234
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 81.3 bits (199), Expect = 2e-15
Identities = 77/353 (21%), Positives = 146/353 (41%), Gaps = 27/353 (7%)
Query: 116 VCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIM-TEQELNQIFG 174
+C+ + L +++ R I E+ E I+ LK + Y K M ++++L IFG
Sbjct: 91 LCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFG 150
Query: 175 TLDSLIPLHEELLSQL-RDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDH 233
++ + + L + D +GP + Y YC+N + A L
Sbjct: 151 NIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSK 210
Query: 234 KKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHL 293
+D R Q F + C + + FL P ++ KYPL L E+L++T D+ D +++
Sbjct: 211 LMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYV 270
Query: 294 EEAINIIQGIVAEINTKTGESE----CRYYKERLLYLEEGQKDSLIDSSRVLCCHGEL-- 347
A+ +++ + +IN + E ++ +L + + + ++D S L GE+
Sbjct: 271 AAALAVMRNVTQQINERKRRLENIDKIAQWQASVL---DWEGEDILDRSSELIYTGEMAW 327
Query: 348 ---KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGG 404
R + FLF +V+ + + Y Y+ I + + D++DG
Sbjct: 328 IYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILY--YKGRIDMDKYEVVDIEDGR----- 380
Query: 405 SLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETV 457
N +KN F++ N + H A K +WL R+ ++ V
Sbjct: 381 ----DDDFNVSMKNAFKL--HNKETEEIHLFFAKKLEEKIRWLRAFREERKMV 427
>gi|21735572 epithelial cell transforming sequence 2 oncogene
protein [Homo sapiens]
Length = 883
Score = 76.3 bits (186), Expect = 7e-14
Identities = 63/258 (24%), Positives = 122/258 (47%), Gaps = 13/258 (5%)
Query: 124 SKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLS-----IMTEQELNQIFGTLDS 178
SK+ R + EL Q E + + L + + P+ + I+ +E+ IFG++
Sbjct: 417 SKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPD 476
Query: 179 LIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCL-SSYDSYCSN-QVAAKALLDHKKQ 236
+ +H ++ L D+ ++ +G I + + L +Y + + +++ + ++ +KQ
Sbjct: 477 IFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQ 536
Query: 237 DHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEA 296
R FL+ P + L L P RL LLL ++ +HT ++NPD+ LE+A
Sbjct: 537 KPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKA 596
Query: 297 INIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCH------GELKNN 350
I ++ ++ IN ++E + ++Y +G +L+ S R L GE +
Sbjct: 597 IGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEHPCD 656
Query: 351 RGVKLHVFLFQEVLVITR 368
RG ++ +FLF + L I R
Sbjct: 657 RGEQVTLFLFNDCLEIAR 674
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 75.1 bits (183), Expect = 1e-13
Identities = 71/309 (22%), Positives = 139/309 (44%), Gaps = 34/309 (11%)
Query: 40 PSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSI---SFRSESRPDILAPRPWSRN 96
P+ +R + + +V L+ +P +R + +L+ S RS S D L S
Sbjct: 742 PTGRR-ETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSP 800
Query: 97 AAPSSTKRR--DSKLWS-----------ETFDVCVNQMLTSKE----IKRQEAIFELSQG 139
+ S DS LWS E++ + V+ +++ IKRQ+ IFEL Q
Sbjct: 801 STESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQT 860
Query: 140 EEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPD-- 197
E I+ L + + + M + + +++IF LD L+ +H +++ R+
Sbjct: 861 EMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCA 920
Query: 198 GST-----EHVGPILVGWLPCLSS------YDSYCSNQVAAKALLDHKKQDHRVQDFLQR 246
GS + +G ILV ++ Y +C + A L +Q+ + Q+F++
Sbjct: 921 GSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKKFQNFIKL 980
Query: 247 CLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAE 306
+ +R+ + + + R+ KYP+L+ IL++T + + L +A+ +I+ ++A
Sbjct: 981 RNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIAT 1040
Query: 307 INTKTGESE 315
++ K E E
Sbjct: 1041 VDLKVNEYE 1049
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 75.1 bits (183), Expect = 1e-13
Identities = 63/259 (24%), Positives = 121/259 (46%), Gaps = 21/259 (8%)
Query: 129 RQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLS 188
R + E+ Q EE E L+ +K + P+ + +T E + +F + L+ LH L+
Sbjct: 193 RSCCLAEIKQTEEKYTETLESIEKYFMAPLKRF--LTAAEFDSVFINIPELVKLHRNLMQ 250
Query: 189 QLRD--VRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDH-KKQDHRVQDFLQ 245
++ D V K D +++ + + + L Y YCS +A + LD+ K V+ L+
Sbjct: 251 EIHDSIVNKND---QNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLE 307
Query: 246 RCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVA 305
C + + K L + L +P R++KY LLL+E+++HT D ++ +L+ A++ ++ +
Sbjct: 308 ECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLALDAMKDLAQ 366
Query: 306 EIN-TKTGESECRYYKERLLYLEEGQKDSLI-------DSSRVLCCHGELKNNRGVKLHV 357
+N K R K+ L +E + L+ R+ K R H+
Sbjct: 367 YVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER----HI 422
Query: 358 FLFQEVLVITRAVTHNEQL 376
FLF +++ + N ++
Sbjct: 423 FLFDLAVIVCKRKGDNYEM 441
>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
Length = 655
Score = 73.6 bits (179), Expect = 4e-13
Identities = 87/383 (22%), Positives = 149/383 (38%), Gaps = 42/383 (10%)
Query: 90 PRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEA--IFELSQGEEDLIEDL 147
PR SR S + S+ W ++ C L+ + E + EL + E+ + L
Sbjct: 65 PRTVSRRYLNSLKNKLSSEAWRKS---CQPVTLSGSGTQEPEKKIVQELLETEQAYVARL 121
Query: 148 KLAKKAYHDPMLKLS----IMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTE-H 202
L + + +LK + E + IF + S+ H + R D +
Sbjct: 122 HLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPR 181
Query: 203 VGPILVGWLPCLSSYDSYCSN-QVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNF 261
+G ++ P L Y Y N + AA+ L + Q+ L R S S L L +
Sbjct: 182 IGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHH 241
Query: 262 LDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKE 321
+ P R+ +Y LLL+E ++ P PDQ ++A+++I N E E R
Sbjct: 242 MLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEME-RLQDL 300
Query: 322 RLLYLEEGQKDSLIDSSRVLCCHG-----ELKNNRGVKLHVFLFQEVLV--ITRAVTHNE 374
+Y G +D ++D S L G + N ++ ++FLF +L+ + R +
Sbjct: 301 WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA 360
Query: 375 QLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHS 434
Q +Q+ R I V + + +L D E F SF + +T
Sbjct: 361 Q--FQV-RTRIDVAGMKVRELMDAE--------------------FPHSFLVSGKQRTLE 397
Query: 435 LQANDTFNKQQWLNCIRQAKETV 457
LQA W+ + A + +
Sbjct: 398 LQARSQEEMISWMQAFQAAIDQI 420
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 72.0 bits (175), Expect = 1e-12
Identities = 78/343 (22%), Positives = 139/343 (40%), Gaps = 21/343 (6%)
Query: 123 TSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIM-TEQELNQIFGTLDSLIP 181
+SK+ R I E+ E D I+ L+ + Y K + M +E++L IFG ++ +
Sbjct: 279 SSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYR 338
Query: 182 LHEELLSQLRD-VRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRV 240
+ + L + +G + Y YC+N A L + +
Sbjct: 339 CQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKY 398
Query: 241 QDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINII 300
F + C + L FL P ++ KYPL L E+L++T + D + +E A++ +
Sbjct: 399 VYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAM 458
Query: 301 QGIVAEINTKTGESE-CRYYKERLLYLEEGQKDSLIDSSRVLCCHGEL-----KNNRGVK 354
+ + IN + E + +E+ + + L+ S L GEL + +
Sbjct: 459 KNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQ 518
Query: 355 LHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNE 414
FLF L+ + + Y Y+ + + L + DL+DG+ R +
Sbjct: 519 RMFFLFDHQLIYCKKDLLRRDVLY--YKGRLDMDGLEVVDLEDGKDR---------DLHV 567
Query: 415 RIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETV 457
IKN FR+ G+ +H L KQ+WL + +E V
Sbjct: 568 SIKNAFRL--HRGATGDSHLLCTRKPEQKQRWLKAFAREREQV 608
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 72.0 bits (175), Expect = 1e-12
Identities = 78/343 (22%), Positives = 139/343 (40%), Gaps = 21/343 (6%)
Query: 123 TSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIM-TEQELNQIFGTLDSLIP 181
+SK+ R I E+ E D I+ L+ + Y K + M +E++L IFG ++ +
Sbjct: 279 SSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYR 338
Query: 182 LHEELLSQLRD-VRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRV 240
+ + L + +G + Y YC+N A L + +
Sbjct: 339 CQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKY 398
Query: 241 QDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINII 300
F + C + L FL P ++ KYPL L E+L++T + D + +E A++ +
Sbjct: 399 VYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAM 458
Query: 301 QGIVAEINTKTGESE-CRYYKERLLYLEEGQKDSLIDSSRVLCCHGEL-----KNNRGVK 354
+ + IN + E + +E+ + + L+ S L GEL + +
Sbjct: 459 KNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQ 518
Query: 355 LHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNE 414
FLF L+ + + Y Y+ + + L + DL+DG+ R +
Sbjct: 519 RMFFLFDHQLIYCKKDLLRRDVLY--YKGRLDMDGLEVVDLEDGKDR---------DLHV 567
Query: 415 RIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETV 457
IKN FR+ G+ +H L KQ+WL + +E V
Sbjct: 568 SIKNAFRL--HRGATGDSHLLCTRKPEQKQRWLKAFAREREQV 608
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,395,287
Number of Sequences: 37866
Number of extensions: 901030
Number of successful extensions: 2833
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 95
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 2643
Number of HSP's gapped (non-prelim): 154
length of query: 532
length of database: 18,247,518
effective HSP length: 107
effective length of query: 425
effective length of database: 14,195,856
effective search space: 6033238800
effective search space used: 6033238800
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.