Search of human proteins with 190885495

Search of human proteins with 190885495

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
[Homo sapiens]
         (558 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ...  1125   0.0  
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H...   994   0.0  
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ...   992   0.0  
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ...   579   e-165
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [...   555   e-158
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]               122   1e-27
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                   107   3e-23
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                   107   3e-23
gi|39930351 dynamin binding protein [Homo sapiens]                     94   4e-19
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...    89   1e-17
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...    89   1e-17
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo...    88   2e-17
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo...    86   1e-16
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor...    86   1e-16
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]           83   6e-16
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]           83   6e-16
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...    82   1e-15
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...    82   1e-15
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...    82   1e-15
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...    82   1e-15
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]        82   2e-15
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]        82   2e-15
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]        82   2e-15
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]              81   2e-15
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]     77   5e-14
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    76   7e-14
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    75   2e-13
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    74   5e-13
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    72   1e-12
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...    72   1e-12

>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
           [Homo sapiens]
          Length = 558

 Score = 1125 bits (2909), Expect = 0.0
 Identities = 558/558 (100%), Positives = 558/558 (100%)

Query: 1   MDSSTAMNQCSCRGMEENKERPKRQRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCS 60
           MDSSTAMNQCSCRGMEENKERPKRQRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCS
Sbjct: 1   MDSSTAMNQCSCRGMEENKERPKRQRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCS 60

Query: 61  LDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWS 120
           LDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWS
Sbjct: 61  LDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWS 120

Query: 121 RNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAY 180
           RNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAY
Sbjct: 121 RNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAY 180

Query: 181 HDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCL 240
           HDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCL
Sbjct: 181 HDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCL 240

Query: 241 SSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPL 300
           SSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPL
Sbjct: 241 SSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPL 300

Query: 301 LLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSL 360
           LLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSL
Sbjct: 301 LLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSL 360

Query: 361 IDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLED 420
           IDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLED
Sbjct: 361 IDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLED 420

Query: 421 LQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAK 480
           LQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAK
Sbjct: 421 LQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAK 480

Query: 481 ETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCER 540
           ETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCER
Sbjct: 481 ETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCER 540

Query: 541 MEQTDSSCGNSRHGESNV 558
           MEQTDSSCGNSRHGESNV
Sbjct: 541 MEQTDSSCGNSRHGESNV 558


>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
           sapiens]
          Length = 526

 Score =  994 bits (2569), Expect = 0.0
 Identities = 495/497 (99%), Positives = 495/497 (99%)

Query: 62  DISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSR 121
           D  EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSR
Sbjct: 30  DAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSR 89

Query: 122 NAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYH 181
           NAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYH
Sbjct: 90  NAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYH 149

Query: 182 DPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLS 241
           DPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLS
Sbjct: 150 DPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLS 209

Query: 242 SYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLL 301
           SYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLL
Sbjct: 210 SYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLL 269

Query: 302 LREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLI 361
           LREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLI
Sbjct: 270 LREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLI 329

Query: 362 DSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDL 421
           DSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDL
Sbjct: 330 DSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDL 389

Query: 422 QDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKE 481
           QDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKE
Sbjct: 390 QDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKE 449

Query: 482 TVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERM 541
           TVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERM
Sbjct: 450 TVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERM 509

Query: 542 EQTDSSCGNSRHGESNV 558
           EQTDSSCGNSRHGESNV
Sbjct: 510 EQTDSSCGNSRHGESNV 526


>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
           [Homo sapiens]
          Length = 532

 Score =  992 bits (2564), Expect = 0.0
 Identities = 494/494 (100%), Positives = 494/494 (100%)

Query: 65  EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAA 124
           EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAA
Sbjct: 39  EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAA 98

Query: 125 PSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM 184
           PSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM
Sbjct: 99  PSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM 158

Query: 185 LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD 244
           LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD
Sbjct: 159 LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD 218

Query: 245 SYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 304
           SYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE
Sbjct: 219 SYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 278

Query: 305 ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS 364
           ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS
Sbjct: 279 ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS 338

Query: 365 RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDG 424
           RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDG
Sbjct: 339 RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDG 398

Query: 425 EVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVL 484
           EVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVL
Sbjct: 399 EVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVL 458

Query: 485 CAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQT 544
           CAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQT
Sbjct: 459 CAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQT 518

Query: 545 DSSCGNSRHGESNV 558
           DSSCGNSRHGESNV
Sbjct: 519 DSSCGNSRHGESNV 532


>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
           [Homo sapiens]
          Length = 596

 Score =  579 bits (1492), Expect = e-165
 Identities = 283/455 (62%), Positives = 365/455 (80%), Gaps = 2/455 (0%)

Query: 25  QRQNNFPMFPSPKAWNFRGRKRKQSTQDEDAVSLCSLDISEPSNKRVKPLSRVTSLANLI 84
           +R ++F        W+F   KRK+  +D+D VSL SLD+ EPSNKRV+PL+RVTSLANLI
Sbjct: 47  RRGSSFTFLTPGPNWDFT-LKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLI 105

Query: 85  PPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCV 144
            PV+   ++RF QT+Q S + R + R    A +  SR+  P+  KRR S LWSE  D+ +
Sbjct: 106 SPVRNGAVRRFGQTIQ-SFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITM 164

Query: 145 NQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDS 204
            + LT++EI+RQEAI+E+S+GE+DLIEDLKLA+KAYHDPMLKLSIM+E+EL  IFG LDS
Sbjct: 165 KESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDS 224

Query: 205 LIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDH 264
            IPLHE+LL+++ +  KPDG+ E +G ILV WLP L++Y  YCSNQ+AAKALLD KKQD 
Sbjct: 225 YIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDP 284

Query: 265 RVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAIN 324
           RVQDFLQRCLESPFSRKLDLW+FLDIPRSRLVKYPLLL+EIL+HTP ++PD Q LE+AI 
Sbjct: 285 RVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAIL 344

Query: 325 IIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVF 384
           IIQG++++IN K GESEC+YY ++L YL+E Q+D  I++S+VL CHGEL++  G KL++F
Sbjct: 345 IIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIF 404

Query: 385 LFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKN 444
           LFQ++LV+TR VT NE+  YQ+YRQPIPV++L+LEDLQDG+VR+GGS RGAFSN+E+ KN
Sbjct: 405 LFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKN 464

Query: 445 FFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQA 479
            FR+ F + S +Q+H+LQAND F+KQQW NCIR A
Sbjct: 465 IFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAA 499


>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2
           [Homo sapiens]
          Length = 542

 Score =  555 bits (1429), Expect = e-158
 Identities = 268/415 (64%), Positives = 342/415 (82%), Gaps = 1/415 (0%)

Query: 65  EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAA 124
           EPSNKRV+PL+RVTSLANLI PV+   ++RF QT+Q S + R + R    A +  SR+  
Sbjct: 32  EPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQ-SFTLRGDHRSPASAQKFSSRSTV 90

Query: 125 PSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPM 184
           P+  KRR S LWSE  D+ + + LT++EI+RQEAI+E+S+GE+DLIEDLKLA+KAYHDPM
Sbjct: 91  PTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPM 150

Query: 185 LKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD 244
           LKLSIM+E+EL  IFG LDS IPLHE+LL+++ +  KPDG+ E +G ILV WLP L++Y 
Sbjct: 151 LKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYR 210

Query: 245 SYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 304
            YCSNQ+AAKALLD KKQD RVQDFLQRCLESPFSRKLDLW+FLDIPRSRLVKYPLLL+E
Sbjct: 211 GYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKE 270

Query: 305 ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSS 364
           IL+HTP ++PD Q LE+AI IIQG++++IN K GESEC+YY ++L YL+E Q+D  I++S
Sbjct: 271 ILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEAS 330

Query: 365 RVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDG 424
           +VL CHGEL++  G KL++FLFQ++LV+TR VT NE+  YQ+YRQPIPV++L+LEDLQDG
Sbjct: 331 KVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDG 390

Query: 425 EVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQA 479
           +VR+GGS RGAFSN+E+ KN FR+ F + S +Q+H+LQAND F+KQQW NCIR A
Sbjct: 391 DVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAA 445


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score =  122 bits (305), Expect = 1e-27
 Identities = 90/327 (27%), Positives = 162/327 (49%), Gaps = 34/327 (10%)

Query: 122  NAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYH 181
            N    +T    S+ W    D+ +  MLT  E KRQ  I EL   EE+ + DL+L  + + 
Sbjct: 1207 NYVKLTTDMDPSQQWCS--DLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQ 1264

Query: 182  DPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGS---TEHVGPILVGWLP 238
             P+++  ++TE+E+  IF     LI  + +LL  LR  +K  G     + +G IL   LP
Sbjct: 1265 KPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLP 1324

Query: 239  CLSSYDSYCSNQVAAKALLDHKKQDHR-VQDFLQRCLESPFSRKLDLWNFLDIPRSRLVK 297
             +  Y  +CS Q+   AL+  K  +    ++F++R    P  + + L +F+  P  R+ +
Sbjct: 1325 HMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTR 1384

Query: 298  YPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLE---- 353
            YPL+++ IL +TP ++PD  HL+ A+   + + +++N    E E     +RL +++    
Sbjct: 1385 YPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKE---NSDRLEWIQAHVQ 1441

Query: 354  -EGQKDSLIDSSRVLCC-------HGEL-KNNRGVKLHVFLFQEVLVIT----------- 393
             EG  + L+ +S   C         G+L K     +L+ FLF + L++T           
Sbjct: 1442 CEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGT 1501

Query: 394  -RAVTHNEQLCYQLYRQPIPVKDLLLE 419
             +  +    L Y++Y+ PI + ++L++
Sbjct: 1502 DKVFSPKSNLQYKMYKTPIFLNEVLVK 1528


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score =  107 bits (267), Expect = 3e-23
 Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)

Query: 152  EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 211
            E KRQ  I EL Q EE  + DL+L  + +   M +   +TE E+  IF     LI  + +
Sbjct: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239

Query: 212  LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 267
            LL  LR  +K  G     + +G IL   L  + +Y  +CS Q+   ALL  K  +D   +
Sbjct: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1299

Query: 268  DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 327
            +FL++    P  + + L +FL  P  R+ +YPLL+R IL +TP  + D   L+ A+   +
Sbjct: 1300 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1359

Query: 328  GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 374
             + +++N    E E     +RL +++     EG  + LI +S       R L   G+L K
Sbjct: 1360 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1416

Query: 375  NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 419
                 +LH FLF + L++T  V      + +E+L        +++Y+ PI + ++L++
Sbjct: 1417 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1474


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score =  107 bits (267), Expect = 3e-23
 Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)

Query: 152  EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 211
            E KRQ  I EL Q EE  + DL+L  + +   M +   +TE E+  IF     LI  + +
Sbjct: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266

Query: 212  LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 267
            LL  LR  +K  G     + +G IL   L  + +Y  +CS Q+   ALL  K  +D   +
Sbjct: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1326

Query: 268  DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 327
            +FL++    P  + + L +FL  P  R+ +YPLL+R IL +TP  + D   L+ A+   +
Sbjct: 1327 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1386

Query: 328  GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 374
             + +++N    E E     +RL +++     EG  + LI +S       R L   G+L K
Sbjct: 1387 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1443

Query: 375  NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 419
                 +LH FLF + L++T  V      + +E+L        +++Y+ PI + ++L++
Sbjct: 1444 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1501


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 71/239 (29%), Positives = 118/239 (49%), Gaps = 23/239 (9%)

Query: 154  KRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELL 213
            KR + I EL Q E D I DL++  +    PM +  +    +   +FG +  +I + ++LL
Sbjct: 784  KRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQV-PNIDFEGLFGNMQMVIKVSKQLL 842

Query: 214  SQLRDVRKPDGSTEHVGPILVGWLPCLS-SYDSYCSNQVAAKALLDHKKQDHRVQDFLQR 272
            + L         ++ VGP+ +G    L  +Y  YC N   A ALL+  ++D ++Q  LQ 
Sbjct: 843  AALE-------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQD 895

Query: 273  CL--------ESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAIN 324
             L        E   +  ++L +FL  P  R+++YPLLL E+L  TP  +PD+  L  A+ 
Sbjct: 896  SLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVL 955

Query: 325  IIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHV 383
             ++ I   IN      E +  K+ +L   +G +DSL++    L  H  +K +  V  H+
Sbjct: 956  AVKEINVNIN------EYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHL 1008


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 100/417 (23%), Positives = 180/417 (43%), Gaps = 36/417 (8%)

Query: 132  DSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMT 191
            D++ W  T    V   LT +EI RQE I EL   E   +  L++    ++  M K ++M 
Sbjct: 752  DAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMP 811

Query: 192  EQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD------S 245
             +EL ++F  L  LI +H      ++ +R+     + +  +++      +  +       
Sbjct: 812  REELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQ 871

Query: 246  YCSNQVAAKALLDHK-KQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 304
            +CS Q  A  L+  K +++ R Q F+Q     P  R+L L + +     RL KYPLLL  
Sbjct: 872  FCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLES 931

Query: 305  ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRY----YKERL--LYLEEGQK- 357
            I++HT     + + L  A +  + I+  +N    ++E R+    Y++RL    LE     
Sbjct: 932  IIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNP 991

Query: 358  -----DSLIDSSRVLCCHGEL----KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYR 408
                  SL  ++R +   G L      ++ + LHV L +++LV+ +    +E+L  + + 
Sbjct: 992  LAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQ--KQDEKLLLKCHS 1049

Query: 409  QPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFN 468
            +   V     +      ++L   L  + + ++R   FF +        Q + L A  + +
Sbjct: 1050 K-TAVGSSDSKQTFSPVLKLNAVLIRSVATDKRA--FFIICTSKLGPPQIYELVALTSSD 1106

Query: 469  KQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRE--LQGETKLE-QMDQSD 522
            K  W+  + +A        G A +         P  G RE   QG T    ++D SD
Sbjct: 1107 KNTWMELLEEAVRNATRHPGAAPM-----PVHPPPPGPREPAQQGPTPSRVELDDSD 1158


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 100/417 (23%), Positives = 180/417 (43%), Gaps = 36/417 (8%)

Query: 132  DSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMT 191
            D++ W  T    V   LT +EI RQE I EL   E   +  L++    ++  M K ++M 
Sbjct: 712  DAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMP 771

Query: 192  EQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYD------S 245
             +EL ++F  L  LI +H      ++ +R+     + +  +++      +  +       
Sbjct: 772  REELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQ 831

Query: 246  YCSNQVAAKALLDHK-KQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLRE 304
            +CS Q  A  L+  K +++ R Q F+Q     P  R+L L + +     RL KYPLLL  
Sbjct: 832  FCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLES 891

Query: 305  ILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRY----YKERL--LYLEEGQK- 357
            I++HT     + + L  A +  + I+  +N    ++E R+    Y++RL    LE     
Sbjct: 892  IIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNP 951

Query: 358  -----DSLIDSSRVLCCHGEL----KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYR 408
                  SL  ++R +   G L      ++ + LHV L +++LV+ +    +E+L  + + 
Sbjct: 952  LAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQ--KQDEKLLLKCHS 1009

Query: 409  QPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFN 468
            +   V     +      ++L   L  + + ++R   FF +        Q + L A  + +
Sbjct: 1010 K-TAVGSSDSKQTFSPVLKLNAVLIRSVATDKRA--FFIICTSKLGPPQIYELVALTSSD 1066

Query: 469  KQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRE--LQGETKLE-QMDQSD 522
            K  W+  + +A        G A +         P  G RE   QG T    ++D SD
Sbjct: 1067 KNTWMELLEEAVRNATRHPGAAPM-----PVHPPPPGPREPAQQGPTPSRVELDDSD 1118


>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
            sapiens]
          Length = 1544

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 78/280 (27%), Positives = 137/280 (48%), Gaps = 28/280 (10%)

Query: 152  EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 211
            EIKRQE I EL   E   +  LK+  + ++  + +  I++  EL +IF  L+ ++ LH  
Sbjct: 785  EIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIG 844

Query: 212  LLSQLRDVRKPDGST--EHVGPILVGWL------PCLSSYDSYCSNQ-VAAKALLDHKKQ 262
            L  Q++ VRK + ++  + +G  L+ W           +  ++CSNQ  A + +   +K+
Sbjct: 845  LNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKK 904

Query: 263  DHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEA 322
            D R Q F+Q    +P  R+L L + +     RL KYPLLL  I ++T     +++ +++A
Sbjct: 905  DSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPT-EREKVKKA 963

Query: 323  INIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLH 382
             +  + I+  +N    E+E    K+RL    E  +  L  SS  L  +  ++  R + L 
Sbjct: 964  ADHCRQILNYVNQAVKEAE---NKQRL----EDYQRRLDTSSLKLSEYPNVEELRNLDL- 1015

Query: 383  VFLFQEVLVITRAVTHNEQLCYQLYR-QPIPVKDLLLEDL 421
                       R + H   L +++ R + I +  LLLED+
Sbjct: 1016 ---------TKRKMIHEGPLVWKVNRDKTIDLYTLLLEDI 1046


>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform
           b [Homo sapiens]
          Length = 1173

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 63/269 (23%), Positives = 125/269 (46%), Gaps = 24/269 (8%)

Query: 94  RFSQTLQRSISFRSESRPDILAPRPWS---RNAAPSSTKRRDSKLWSETFDVCVNQMLTS 150
           +F QT   S+S  S +   I    P++   R+   S     +++ WS   D    +    
Sbjct: 196 KFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKR 255

Query: 151 KEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHE 210
           + +KRQ+ ++EL Q E   +  LK+  K Y   + +    + + + ++F   D L+  H 
Sbjct: 256 EVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHS 315

Query: 211 ELLSQLRDVRKP---DGSTEH-----VGPILVGWLP------CLSSYDSYCSNQVAA--- 253
             L++L++ R+    +GS  +     +G +LV              Y  +CS    A   
Sbjct: 316 HFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSH 375

Query: 254 -KALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPND 312
            K LL   +Q+ + Q+ +++       R+L +   + +   R+ KYP+L+  I+++T   
Sbjct: 376 YKLLL---QQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAG 432

Query: 313 NPDQQHLEEAINIIQGIVAEINTKTGESE 341
             D + L +A+N+I+ I+++++ K  E E
Sbjct: 433 TEDYEDLTQALNLIKDIISQVDAKVSECE 461


>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
           [Homo sapiens]
          Length = 1015

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 63/269 (23%), Positives = 125/269 (46%), Gaps = 24/269 (8%)

Query: 94  RFSQTLQRSISFRSESRPDILAPRPWS---RNAAPSSTKRRDSKLWSETFDVCVNQMLTS 150
           +F QT   S+S  S +   I    P++   R+   S     +++ WS   D    +    
Sbjct: 38  KFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKR 97

Query: 151 KEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHE 210
           + +KRQ+ ++EL Q E   +  LK+  K Y   + +    + + + ++F   D L+  H 
Sbjct: 98  EVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHS 157

Query: 211 ELLSQLRDVRKP---DGSTEH-----VGPILVGWLP------CLSSYDSYCSNQVAA--- 253
             L++L++ R+    +GS  +     +G +LV              Y  +CS    A   
Sbjct: 158 HFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSH 217

Query: 254 -KALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPND 312
            K LL   +Q+ + Q+ +++       R+L +   + +   R+ KYP+L+  I+++T   
Sbjct: 218 YKLLL---QQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAG 274

Query: 313 NPDQQHLEEAINIIQGIVAEINTKTGESE 341
             D + L +A+N+I+ I+++++ K  E E
Sbjct: 275 TEDYEDLTQALNLIKDIISQVDAKVSECE 303


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 82/350 (23%), Positives = 156/350 (44%), Gaps = 47/350 (13%)

Query: 161 ELSQGEEDLIEDLKLAKKAYHDPMLKLSI------MTEQELNQIFGTLDSLIPLHEELLS 214
           EL + E D +  L+    A+   M + +       +TE+ +  +F  ++ ++ +H+E L 
Sbjct: 30  ELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLK 89

Query: 215 QLRDVRKPD-GSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRC 273
            + +   P+  + + VG   + +      YD YCSN   A+ LL    +   ++ FL  C
Sbjct: 90  VVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNC 149

Query: 274 LESPFSRKLD--LWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVA 331
           +     +  D  L  +L  P  R+ KYPL+L+E+L+ TP  + D   + EA+  ++ + +
Sbjct: 150 MLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCS 209

Query: 332 EINTKTGESECRYYKERLLYLEEGQK-------DSLIDS-SRVLCCHGELKNNRG-VKLH 382
            IN      E +   E+L  LEE Q         ++ D+ + +L C   LK + G ++  
Sbjct: 210 NIN------EAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQER 263

Query: 383 V-FLFQEVLVI----------TRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGS 431
           V FLF  +LV           ++A T   +    L+R  I  + + +E++ DG       
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHR---YLFRGRINTEVMEVENVDDGTADF--- 317

Query: 432 LRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKE 481
                S+   + N +++   N ++++     A     K +W   I + +E
Sbjct: 318 ----HSSGHIVVNGWKI--HNTAKNKWFVCMAKTPEEKHEWFEAILKERE 361


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 82/350 (23%), Positives = 156/350 (44%), Gaps = 47/350 (13%)

Query: 161 ELSQGEEDLIEDLKLAKKAYHDPMLKLSI------MTEQELNQIFGTLDSLIPLHEELLS 214
           EL + E D +  L+    A+   M + +       +TE+ +  +F  ++ ++ +H+E L 
Sbjct: 30  ELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKEFLK 89

Query: 215 QLRDVRKPD-GSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRC 273
            + +   P+  + + VG   + +      YD YCSN   A+ LL    +   ++ FL  C
Sbjct: 90  VVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRTIRTFLLNC 149

Query: 274 LESPFSRKLD--LWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVA 331
           +     +  D  L  +L  P  R+ KYPL+L+E+L+ TP  + D   + EA+  ++ + +
Sbjct: 150 MLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQAMKAVCS 209

Query: 332 EINTKTGESECRYYKERLLYLEEGQK-------DSLIDS-SRVLCCHGELKNNRG-VKLH 382
            IN      E +   E+L  LEE Q         ++ D+ + +L C   LK + G ++  
Sbjct: 210 NIN------EAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGNIQER 263

Query: 383 V-FLFQEVLVI----------TRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGS 431
           V FLF  +LV           ++A T   +    L+R  I  + + +E++ DG       
Sbjct: 264 VFFLFDNLLVYCKRKHRRLKNSKASTDGHR---YLFRGRINTEVMEVENVDDGTADF--- 317

Query: 432 LRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKE 481
                S+   + N +++   N ++++     A     K +W   I + +E
Sbjct: 318 ----HSSGHIVVNGWKI--HNTAKNKWFVCMAKTPEEKHEWFEAILKERE 361


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 71/311 (22%), Positives = 142/311 (45%), Gaps = 28/311 (9%)

Query: 190 MTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEH-VGPILVGWLPCLSSYDSYCS 248
           +TE+ +  +F  ++ ++ +H++ L+ L     P+  ++H +G + + +      Y+ YCS
Sbjct: 91  LTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCS 150

Query: 249 NQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLD--LWNFLDIPRSRLVKYPLLLREIL 306
           N   A  LL    +   V+ FL  C+     +  D  L  +L  P  R+ KYPLLL+E+ 
Sbjct: 151 NHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELA 210

Query: 307 RHTPNDNPDQQHLEEAINIIQGIVAEIN-TKTGESECRYYKERLLYLEEGQKDSLIDSSR 365
           + TP  +PD   ++ A+  ++ + + IN TK    +    ++   ++E  +  +L D   
Sbjct: 211 KRTPGKHPDHPAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICT 270

Query: 366 VLCCHGELKNNRGVKLH---VFLFQEVLVITR---AVTHNEQLCYQ---------LYRQP 410
            L   G L       +     FLF  +LV  +    VT +++   +         ++R  
Sbjct: 271 QLLLQGTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGR 330

Query: 411 IPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQ 470
           I  + + +E+++DG            SN   + N +++   N ++++     A     KQ
Sbjct: 331 INTEVMEVENVEDGTA-------DYHSNGYTVTNGWKI--HNTAKNKWFVCMAKTAEEKQ 381

Query: 471 QWLNCIRQAKE 481
           +WL+ I + +E
Sbjct: 382 KWLDAIIRERE 392


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
           [Homo sapiens]
          Length = 927

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 89/372 (23%), Positives = 157/372 (42%), Gaps = 41/372 (11%)

Query: 136 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQEL 195
           W E         L   ++KRQE I EL   E   +  L++    +  PM +      +EL
Sbjct: 413 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 472

Query: 196 NQIFGTLDSLIPLHEELLSQLRDVRKPDG-STEHVGPILV--------GWLPCLSSYDSY 246
             IF +LD LI +H   L +L   R+  G   E +G +L+         W   +SS   +
Sbjct: 473 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 530

Query: 247 CSNQ-VAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREI 305
           CS Q  A + L   +++D R   F+Q     P  R+L L + +     RL KYPLLL+ I
Sbjct: 531 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 590

Query: 306 LRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESE----CRYYKER--LLYLEEGQKDS 359
            ++T  +  +++ +E A    + I+  +N    + E     + Y+ R  L +L +     
Sbjct: 591 GQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPM 649

Query: 360 L-----IDSSRVLCCH-----GELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQ 409
           L     +D ++    H       +  ++ V++HV L  ++L++ +    +E+L  + + +
Sbjct: 650 LSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQ--RQDERLLLKSHSR 707

Query: 410 PIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERI---KNFFRVSFKNGSQSQTHSLQANDT 466
                   L    DG+  L   LR   +    +      F V F    ++Q + L A   
Sbjct: 708 -------TLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTV 760

Query: 467 FNKQQWLNCIRQ 478
             ++ W   I +
Sbjct: 761 SERKNWCALITE 772


>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
           [Homo sapiens]
          Length = 879

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 89/372 (23%), Positives = 157/372 (42%), Gaps = 41/372 (11%)

Query: 136 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQEL 195
           W E         L   ++KRQE I EL   E   +  L++    +  PM +      +EL
Sbjct: 365 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 424

Query: 196 NQIFGTLDSLIPLHEELLSQLRDVRKPDG-STEHVGPILV--------GWLPCLSSYDSY 246
             IF +LD LI +H   L +L   R+  G   E +G +L+         W   +SS   +
Sbjct: 425 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 482

Query: 247 CSNQ-VAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREI 305
           CS Q  A + L   +++D R   F+Q     P  R+L L + +     RL KYPLLL+ I
Sbjct: 483 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 542

Query: 306 LRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESE----CRYYKER--LLYLEEGQKDS 359
            ++T  +  +++ +E A    + I+  +N    + E     + Y+ R  L +L +     
Sbjct: 543 GQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPM 601

Query: 360 L-----IDSSRVLCCH-----GELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQ 409
           L     +D ++    H       +  ++ V++HV L  ++L++ +    +E+L  + + +
Sbjct: 602 LSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQ--RQDERLLLKSHSR 659

Query: 410 PIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERI---KNFFRVSFKNGSQSQTHSLQANDT 466
                   L    DG+  L   LR   +    +      F V F    ++Q + L A   
Sbjct: 660 -------TLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTV 712

Query: 467 FNKQQWLNCIRQ 478
             ++ W   I +
Sbjct: 713 SERKNWCALITE 724


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
           [Homo sapiens]
          Length = 912

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 89/372 (23%), Positives = 157/372 (42%), Gaps = 41/372 (11%)

Query: 136 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQEL 195
           W E         L   ++KRQE I EL   E   +  L++    +  PM +      +EL
Sbjct: 398 WRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEEL 457

Query: 196 NQIFGTLDSLIPLHEELLSQLRDVRKPDG-STEHVGPILV--------GWLPCLSSYDSY 246
             IF +LD LI +H   L +L   R+  G   E +G +L+         W   +SS   +
Sbjct: 458 QNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS--RF 515

Query: 247 CSNQ-VAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREI 305
           CS Q  A + L   +++D R   F+Q     P  R+L L + +     RL KYPLLL+ I
Sbjct: 516 CSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSI 575

Query: 306 LRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESE----CRYYKER--LLYLEEGQKDS 359
            ++T  +  +++ +E A    + I+  +N    + E     + Y+ R  L +L +     
Sbjct: 576 GQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPM 634

Query: 360 L-----IDSSRVLCCH-----GELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQ 409
           L     +D ++    H       +  ++ V++HV L  ++L++ +    +E+L  + + +
Sbjct: 635 LSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQ--RQDERLLLKSHSR 692

Query: 410 PIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERI---KNFFRVSFKNGSQSQTHSLQANDT 466
                   L    DG+  L   LR   +    +      F V F    ++Q + L A   
Sbjct: 693 -------TLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTV 745

Query: 467 FNKQQWLNCIRQ 478
             ++ W   I +
Sbjct: 746 SERKNWCALITE 757


>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
          Length = 2817

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)

Query: 128  TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 187
            +K+ +++ WS   D    +      +KRQE I+EL Q E   +  LK+    Y   M+  
Sbjct: 1972 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2031

Query: 188  SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 238
             +  +Q + ++F  LD LI +H +   ++ + +K    D S ++     +G +LV     
Sbjct: 2032 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2091

Query: 239  -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 292
                    +Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 2092 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2151

Query: 293  SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 352
             R+ KYP+L + IL+ T ++  +Q+ L +++++++ ++  +++K    E +  +   +Y 
Sbjct: 2152 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 2210

Query: 353  EEGQKDSLIDSSRVLCCHGELKNNRGVK 380
            +   K  +   S  +    +LK  + V+
Sbjct: 2211 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 2238


>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
          Length = 1058

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)

Query: 128 TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 187
           +K+ +++ WS   D    +      +KRQE I+EL Q E   +  LK+    Y   M+  
Sbjct: 213 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 272

Query: 188 SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 238
            +  +Q + ++F  LD LI +H +   ++ + +K    D S ++     +G +LV     
Sbjct: 273 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 332

Query: 239 -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 292
                   +Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 333 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 392

Query: 293 SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 352
            R+ KYP+L + IL+ T ++  +Q+ L +++++++ ++  +++K    E +  +   +Y 
Sbjct: 393 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 451

Query: 353 EEGQKDSLIDSSRVLCCHGELKNNRGVK 380
           +   K  +   S  +    +LK  + V+
Sbjct: 452 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 479


>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
          Length = 2813

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)

Query: 128  TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 187
            +K+ +++ WS   D    +      +KRQE I+EL Q E   +  LK+    Y   M+  
Sbjct: 1968 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2027

Query: 188  SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 238
             +  +Q + ++F  LD LI +H +   ++ + +K    D S ++     +G +LV     
Sbjct: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2087

Query: 239  -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 292
                    +Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 2088 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2147

Query: 293  SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 352
             R+ KYP+L + IL+ T ++  +Q+ L +++++++ ++  +++K    E +  +   +Y 
Sbjct: 2148 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 2206

Query: 353  EEGQKDSLIDSSRVLCCHGELKNNRGVK 380
            +   K  +   S  +    +LK  + V+
Sbjct: 2207 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 2234


>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 77/353 (21%), Positives = 146/353 (41%), Gaps = 27/353 (7%)

Query: 142 VCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIM-TEQELNQIFG 200
           +C+ + L +++  R   I E+   E   I+ LK   + Y     K   M ++++L  IFG
Sbjct: 91  LCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFG 150

Query: 201 TLDSLIPLHEELLSQL-RDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDH 259
            ++ +       +  L +     D     +GP  +        Y  YC+N + A   L  
Sbjct: 151 NIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSK 210

Query: 260 KKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHL 319
             +D R Q F + C        + +  FL  P  ++ KYPL L E+L++T  D+ D +++
Sbjct: 211 LMKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYV 270

Query: 320 EEAINIIQGIVAEINTKTGESE----CRYYKERLLYLEEGQKDSLIDSSRVLCCHGEL-- 373
             A+ +++ +  +IN +    E       ++  +L   + + + ++D S  L   GE+  
Sbjct: 271 AAALAVMRNVTQQINERKRRLENIDKIAQWQASVL---DWEGEDILDRSSELIYTGEMAW 327

Query: 374 ---KNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGG 430
                 R  +   FLF   +V+ +       + Y  Y+  I +    + D++DG      
Sbjct: 328 IYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDILY--YKGRIDMDKYEVVDIEDGR----- 380

Query: 431 SLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETV 483
                   N  +KN F++   N    + H   A     K +WL   R+ ++ V
Sbjct: 381 ----DDDFNVSMKNAFKL--HNKETEEIHLFFAKKLEEKIRWLRAFREERKMV 427


>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
          Length = 1651

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 34/315 (10%)

Query: 60   SLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSI---SFRSESRPDILAP 116
            S+ +  P+ +R + + +V  L+  +P       +R + +L+      S RS S  D L  
Sbjct: 736  SVPVGLPTGRR-ETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQ 794

Query: 117  RPWSRNAAPSSTKRR--DSKLWS-----------ETFDVCVNQMLTSKE----IKRQEAI 159
               S  +  S       DS LWS           E++ + V+    +++    IKRQ+ I
Sbjct: 795  SMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVI 854

Query: 160  FELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDV 219
            FEL Q E   I+ L +  + +   M +   +    +++IF  LD L+ +H      +++ 
Sbjct: 855  FELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKER 914

Query: 220  RKPD--GST-----EHVGPILVGWLPCLSS------YDSYCSNQVAAKALLDHKKQDHRV 266
            R+    GS      + +G ILV      ++      Y  +C +   A  L    +Q+ + 
Sbjct: 915  RQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKKF 974

Query: 267  QDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINII 326
            Q+F++    +  +R+  +   + +   R+ KYP+L+  IL++T     + + L +A+ +I
Sbjct: 975  QNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLI 1034

Query: 327  QGIVAEINTKTGESE 341
            + ++A ++ K  E E
Sbjct: 1035 KDMIATVDLKVNEYE 1049


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 63/258 (24%), Positives = 122/258 (47%), Gaps = 13/258 (5%)

Query: 150 SKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLS-----IMTEQELNQIFGTLDS 204
           SK+  R +   EL Q E + +  L    + +  P+ +       I+  +E+  IFG++  
Sbjct: 417 SKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPD 476

Query: 205 LIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCL-SSYDSYCSN-QVAAKALLDHKKQ 262
           +  +H ++   L D+      ++ +G I + +   L  +Y  + +  +++ + ++  +KQ
Sbjct: 477 IFDVHTKIKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQ 536

Query: 263 DHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEA 322
             R   FL+     P   +  L   L  P  RL    LLL ++ +HT ++NPD+  LE+A
Sbjct: 537 KPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKA 596

Query: 323 INIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCH------GELKNN 376
           I  ++ ++  IN    ++E +     ++Y  +G   +L+ S R L         GE   +
Sbjct: 597 IGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETISLGEHPCD 656

Query: 377 RGVKLHVFLFQEVLVITR 394
           RG ++ +FLF + L I R
Sbjct: 657 RGEQVTLFLFNDCLEIAR 674


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 63/259 (24%), Positives = 121/259 (46%), Gaps = 21/259 (8%)

Query: 155 RQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLS 214
           R   + E+ Q EE   E L+  +K +  P+ +   +T  E + +F  +  L+ LH  L+ 
Sbjct: 193 RSCCLAEIKQTEEKYTETLESIEKYFMAPLKRF--LTAAEFDSVFINIPELVKLHRNLMQ 250

Query: 215 QLRD--VRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDH-KKQDHRVQDFLQ 271
           ++ D  V K D   +++  + + +   L  Y  YCS   +A + LD+  K    V+  L+
Sbjct: 251 EIHDSIVNKND---QNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVKLKLE 307

Query: 272 RCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVA 331
            C +   + K  L + L +P  R++KY LLL+E+++HT  D  ++ +L+ A++ ++ +  
Sbjct: 308 ECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT-TDPTEKANLKLALDAMKDLAQ 366

Query: 332 EIN-TKTGESECRYYKERLLYLEEGQKDSLI-------DSSRVLCCHGELKNNRGVKLHV 383
            +N  K      R  K+  L +E   +  L+          R+       K  R    H+
Sbjct: 367 YVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQER----HI 422

Query: 384 FLFQEVLVITRAVTHNEQL 402
           FLF   +++ +    N ++
Sbjct: 423 FLFDLAVIVCKRKGDNYEM 441


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 87/383 (22%), Positives = 149/383 (38%), Gaps = 42/383 (10%)

Query: 116 PRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEA--IFELSQGEEDLIEDL 173
           PR  SR    S   +  S+ W ++   C    L+    +  E   + EL + E+  +  L
Sbjct: 65  PRTVSRRYLNSLKNKLSSEAWRKS---CQPVTLSGSGTQEPEKKIVQELLETEQAYVARL 121

Query: 174 KLAKKAYHDPMLKLS----IMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTE-H 228
            L  + +   +LK +       E  +  IF  + S+   H +        R  D +    
Sbjct: 122 HLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPR 181

Query: 229 VGPILVGWLPCLSSYDSYCSN-QVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNF 287
           +G ++    P L  Y  Y  N + AA+ L     +    Q+ L R   S  S  L L + 
Sbjct: 182 IGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHH 241

Query: 288 LDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKE 347
           +  P  R+ +Y LLL+E ++  P   PDQ   ++A+++I       N    E E R    
Sbjct: 242 MLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEME-RLQDL 300

Query: 348 RLLYLEEGQKDSLIDSSRVLCCHG-----ELKNNRGVKLHVFLFQEVLV--ITRAVTHNE 400
             +Y   G +D ++D S  L   G       + N  ++ ++FLF  +L+  + R +    
Sbjct: 301 WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA 360

Query: 401 QLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHS 460
           Q  +Q+ R  I V  + + +L D E                    F  SF    + +T  
Sbjct: 361 Q--FQV-RTRIDVAGMKVRELMDAE--------------------FPHSFLVSGKQRTLE 397

Query: 461 LQANDTFNKQQWLNCIRQAKETV 483
           LQA        W+   + A + +
Sbjct: 398 LQARSQEEMISWMQAFQAAIDQI 420


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 78/343 (22%), Positives = 139/343 (40%), Gaps = 21/343 (6%)

Query: 149 TSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIM-TEQELNQIFGTLDSLIP 207
           +SK+  R   I E+   E D I+ L+   + Y     K + M +E++L  IFG ++ +  
Sbjct: 279 SSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYR 338

Query: 208 LHEELLSQLRD-VRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRV 266
             +  +  L     +       +G   +        Y  YC+N   A   L    +  + 
Sbjct: 339 CQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKY 398

Query: 267 QDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINII 326
             F + C        + L  FL  P  ++ KYPL L E+L++T   + D + +E A++ +
Sbjct: 399 VYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAM 458

Query: 327 QGIVAEINTKTGESE-CRYYKERLLYLEEGQKDSLIDSSRVLCCHGEL-----KNNRGVK 380
           + +   IN +    E      +    +E+ + + L+  S  L   GEL        +  +
Sbjct: 459 KNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQ 518

Query: 381 LHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNE 440
              FLF   L+  +       + Y  Y+  + +  L + DL+DG+ R           + 
Sbjct: 519 RMFFLFDHQLIYCKKDLLRRDVLY--YKGRLDMDGLEVVDLEDGKDR---------DLHV 567

Query: 441 RIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETV 483
            IKN FR+    G+   +H L       KQ+WL    + +E V
Sbjct: 568 SIKNAFRL--HRGATGDSHLLCTRKPEQKQRWLKAFAREREQV 608


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 78/343 (22%), Positives = 139/343 (40%), Gaps = 21/343 (6%)

Query: 149 TSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIM-TEQELNQIFGTLDSLIP 207
           +SK+  R   I E+   E D I+ L+   + Y     K + M +E++L  IFG ++ +  
Sbjct: 279 SSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYR 338

Query: 208 LHEELLSQLRD-VRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRV 266
             +  +  L     +       +G   +        Y  YC+N   A   L    +  + 
Sbjct: 339 CQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKY 398

Query: 267 QDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINII 326
             F + C        + L  FL  P  ++ KYPL L E+L++T   + D + +E A++ +
Sbjct: 399 VYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAM 458

Query: 327 QGIVAEINTKTGESE-CRYYKERLLYLEEGQKDSLIDSSRVLCCHGEL-----KNNRGVK 380
           + +   IN +    E      +    +E+ + + L+  S  L   GEL        +  +
Sbjct: 459 KNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQ 518

Query: 381 LHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNE 440
              FLF   L+  +       + Y  Y+  + +  L + DL+DG+ R           + 
Sbjct: 519 RMFFLFDHQLIYCKKDLLRRDVLY--YKGRLDMDGLEVVDLEDGKDR---------DLHV 567

Query: 441 RIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETV 483
            IKN FR+    G+   +H L       KQ+WL    + +E V
Sbjct: 568 SIKNAFRL--HRGATGDSHLLCTRKPEQKQRWLKAFAREREQV 608


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,691,499
Number of Sequences: 37866
Number of extensions: 977626
Number of successful extensions: 3122
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 2931
Number of HSP's gapped (non-prelim): 158
length of query: 558
length of database: 18,247,518
effective HSP length: 107
effective length of query: 451
effective length of database: 14,195,856
effective search space: 6402331056
effective search space used: 6402331056
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.