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Search of human proteins with 189095269
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189095269 propionyl-Coenzyme A carboxylase, alpha
polypeptide isoform b [Homo sapiens]
(702 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189095269 propionyl-Coenzyme A carboxylase, alpha polypeptide... 1382 0.0
gi|65506442 propionyl-Coenzyme A carboxylase, alpha polypeptide ... 1368 0.0
gi|116805327 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) pr... 473 e-133
gi|106049528 pyruvate carboxylase precursor [Homo sapiens] 377 e-104
gi|106049295 pyruvate carboxylase precursor [Homo sapiens] 377 e-104
gi|106049292 pyruvate carboxylase precursor [Homo sapiens] 377 e-104
gi|38679977 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo ... 248 2e-65
gi|38679974 acetyl-Coenzyme A carboxylase alpha isoform 4 [Homo ... 248 2e-65
gi|38679971 acetyl-Coenzyme A carboxylase alpha isoform 3 [Homo ... 248 2e-65
gi|38679967 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo ... 248 2e-65
gi|38679960 acetyl-Coenzyme A carboxylase alpha isoform 1 [Homo ... 248 2e-65
gi|134142062 acetyl-Coenzyme A carboxylase beta [Homo sapiens] 245 1e-64
gi|18105007 carbamoylphosphate synthetase 2/aspartate transcarba... 63 1e-09
gi|169790915 carbamoyl-phosphate synthetase 1 isoform a precurso... 56 1e-07
gi|21361331 carbamoyl-phosphate synthetase 1 isoform b precursor... 56 1e-07
gi|170295797 carbamoyl-phosphate synthetase 1 isoform c [Homo sa... 54 4e-07
gi|110671329 dihydrolipoamide branched chain transacylase precur... 33 0.90
gi|212549738 anaphase-promoting complex subunit 7 isoform b [Hom... 32 1.5
gi|212549736 anaphase-promoting complex subunit 7 isoform a [Hom... 32 1.5
gi|28416899 phosphoribosylglycinamide formyltransferase, phospho... 30 5.8
gi|4503915 phosphoribosylglycinamide formyltransferase, phosphor... 30 5.8
gi|209869995 phosphoribosylglycinamide formyltransferase, phosph... 30 5.8
gi|209869993 phosphoribosylglycinamide formyltransferase, phosph... 30 5.8
gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens] 30 5.8
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 30 7.6
gi|239751247 PREDICTED: similar to mitogen-activated protein kin... 30 7.6
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 30 7.6
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 30 7.6
gi|4505941 DNA directed RNA polymerase II polypeptide B [Homo sa... 30 7.6
gi|164663810 ribosomal modification protein rimK-like family mem... 30 10.0
>gi|189095269 propionyl-Coenzyme A carboxylase, alpha polypeptide
isoform b [Homo sapiens]
Length = 702
Score = 1382 bits (3578), Expect = 0.0
Identities = 702/702 (100%), Positives = 702/702 (100%)
Query: 1 MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKTFDKILVANRGEIACRVIRTCKKMG 60
MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKTFDKILVANRGEIACRVIRTCKKMG
Sbjct: 1 MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKTFDKILVANRGEIACRVIRTCKKMG 60
Query: 61 IKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFL 120
IKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFL
Sbjct: 61 IKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFL 120
Query: 121 SENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGVVKDAEEAV 180
SENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGVVKDAEEAV
Sbjct: 121 SENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGVVKDAEEAV 180
Query: 181 RIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDN 240
RIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDN
Sbjct: 181 RIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKFIDN 240
Query: 241 PRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARA 300
PRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARA
Sbjct: 241 PRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVALARA 300
Query: 301 VKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQ 360
VKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQ
Sbjct: 301 VKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQ 360
Query: 361 ADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISIYYD 420
ADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISIYYD
Sbjct: 361 ADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISIYYD 420
Query: 421 PMISKLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSD 480
PMISKLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSD
Sbjct: 421 PMISKLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKFLSD 480
Query: 481 VYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLH 540
VYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLH
Sbjct: 481 VYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLH 540
Query: 541 DKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMS 600
DKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMS
Sbjct: 541 DKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMS 600
Query: 601 IQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQE 660
IQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQE
Sbjct: 601 IQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQE 660
Query: 661 ICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLLVELE 702
ICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLLVELE
Sbjct: 661 ICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLLVELE 702
>gi|65506442 propionyl-Coenzyme A carboxylase, alpha polypeptide
isoform a precursor [Homo sapiens]
Length = 728
Score = 1368 bits (3541), Expect = 0.0
Identities = 702/728 (96%), Positives = 702/728 (96%), Gaps = 26/728 (3%)
Query: 1 MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLK------------------------- 35
MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLK
Sbjct: 1 MAGFWVGTAPLVAAGRRGRWPPQQLMLSAALRTLKHVLYYSRQCLMVSRNLGSVGYDPNE 60
Query: 36 -TFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS 94
TFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS
Sbjct: 61 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKS 120
Query: 95 YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES 154
YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES
Sbjct: 121 YLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIES 180
Query: 155 KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD 214
KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD
Sbjct: 181 KLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD 240
Query: 215 GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV 274
GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV
Sbjct: 241 GFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVV 300
Query: 275 EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV 334
EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV
Sbjct: 301 EEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPV 360
Query: 335 TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY 394
TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY
Sbjct: 361 TECITGLDLVQEMIRVAKGYPLRHKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQY 420
Query: 395 QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH 454
QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH
Sbjct: 421 QEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTH 480
Query: 455 NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA 514
NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA
Sbjct: 481 NIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQLLAIASSLFVAFQLRA 540
Query: 515 QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS 574
QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS
Sbjct: 541 QHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS 600
Query: 575 PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS 634
PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS
Sbjct: 601 PLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSS 660
Query: 635 VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE 694
VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE
Sbjct: 661 VLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGE 720
Query: 695 GDLLVELE 702
GDLLVELE
Sbjct: 721 GDLLVELE 728
>gi|116805327 methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
precursor [Homo sapiens]
Length = 725
Score = 473 bits (1217), Expect = e-133
Identities = 285/724 (39%), Positives = 415/724 (57%), Gaps = 50/724 (6%)
Query: 11 LVAAGRRGRW--------PPQ-----QLMLSAALRTLKTFDKILVANRGEIACRVIRTCK 57
L+ A R RW PP+ Q + T + K+L+ANRGEIACRV+RT K
Sbjct: 10 LLVAAERNRWHRLPSLLLPPRTWVWRQRTMKYTTATGRNITKVLIANRGEIACRVMRTAK 69
Query: 58 KMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGY 117
K+G++TVA++S+ D +S+HV MADEA +GPAP+ +SYL+M+ I++ K + AQA+HPG
Sbjct: 70 KLGVQTVAVYSEADRNSMHVDMADEAYSIGPAPSQQSYLSMEKIIQVAKTSAAQAIHPGC 129
Query: 118 GFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGVVKDAE 177
GFLSEN EFA E ++FIGP AI+ MG K SK + A V + G+ G + +
Sbjct: 130 GFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQ 189
Query: 178 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 237
AR IGYPVMIKA GGGGKGMRI ++E ++ + +EA SF DD +LIEKF
Sbjct: 190 CLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKF 249
Query: 238 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 297
+D PRH+E+QV GD HGNA++L ER+CS+QRR+QK++EEAP+ + +E R+ +GE AV
Sbjct: 250 VDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRA 309
Query: 298 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 357
A+AV Y AGTVEF++DSK NF F+EMNTRLQVEHPVTE ITG DLV+ +R+A G +
Sbjct: 310 AKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIP 369
Query: 358 HKQADIRINGWAVECRVYAEDPYKSFGLPSIGRLSQYQEPLHLPGVRVDSGIQPGSDISI 417
Q +I + G A E R+YAEDP +F +P G L P P R+++G++ G ++S+
Sbjct: 370 LSQEEITLQGHAFEARIYAEDPSNNF-MPVAGPLVHLSTPRADPSTRIETGVRQGDEVSV 428
Query: 418 YYDPMISKLITYGSDRTEALKRMADALDNYVIRGVTHNIALLREVIINSRFVKGDISTKF 477
+YDPMI+KL+ + +DR AL ++ +L Y I G+ NI L + + F G++ T F
Sbjct: 429 HYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDF 488
Query: 478 LSDVYPDGFKGHMLTK--SEKNQLLAIASSLFV-------AFQLRA-QHFQENSRMPVIK 527
+ P K +L++ + K L A L + F L+A F S +
Sbjct: 489 I----PQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRR 544
Query: 528 PDIANWELSVKLHD---KVHTVVASNNGSVFSVEVDGSKLNVTSTWNLAS----PLLSVS 580
+I ++ ++ L D V V N+ +S++++ V NL S L S
Sbjct: 545 LNI-SYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLG--NLYSEGDCTYLKCS 601
Query: 581 VDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAEL--NKFMLEKVTEDTSSVLRS 638
V+G + + E T+Y + + ++ K++ +++T +
Sbjct: 602 VNGVASKAKLIILE----------NTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLA 651
Query: 639 PMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLL 698
PM G + V VK GD V G + V+ AMKM++++ + K GTVK V + G L
Sbjct: 652 PMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPL 711
Query: 699 VELE 702
VE E
Sbjct: 712 VEFE 715
>gi|106049528 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 377 bits (969), Expect = e-104
Identities = 202/452 (44%), Positives = 291/452 (64%), Gaps = 9/452 (1%)
Query: 35 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGP--APTS 92
K K++VANRGEIA RV R C ++GI+TVAI+S+ D +H + ADEA +G AP
Sbjct: 35 KPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPV- 93
Query: 93 KSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKI 152
++YL++ I++ K+ AVHPGYGFLSE +FA+ V FIGP ++ MGDK+
Sbjct: 94 QAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKV 153
Query: 153 ESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEET 212
E++ +A A V +PG D + EA + G+P++ KA+ GGGG+GMR+ EE
Sbjct: 154 EARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEEL 213
Query: 213 RDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQK 272
+ + + EA ++FG+ L +EKFI+ PRHIE+Q+LGD++GN L L ER+CSIQRR+QK
Sbjct: 214 EENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQK 273
Query: 273 VVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEH 332
VVE AP+ LD + R + +V LA+ V Y +AGTVEFLVD YF+E+N+RLQVEH
Sbjct: 274 VVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEH 333
Query: 333 PVTECITGLDLVQEMIRVAKGYPLRH---KQADIRINGWAVECRVYAEDPYKSFGLPSIG 389
VTE IT +DLV I VA+G L +Q +IRING A++CRV EDP +SF P G
Sbjct: 334 TVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSF-QPDTG 392
Query: 390 RLSQYQEPLHLPGVRVDSGIQ-PGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYV 448
R+ ++ + G+R+D+ G+ IS +YD ++ K+I +G D A +M+ AL +
Sbjct: 393 RIEVFRSGEGM-GIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFR 451
Query: 449 IRGVTHNIALLREVIINSRFVKGDISTKFLSD 480
+RGV NIA L+ V+ N +F+ G + T+F+ +
Sbjct: 452 VRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDE 483
Score = 62.8 bits (151), Expect = 1e-09
Identities = 30/76 (39%), Positives = 46/76 (60%)
Query: 627 KVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHC 686
K +D + +PMPG V+ + V G VA+GQ +CV+ AMKM+ +T+ GTV+ VH
Sbjct: 1103 KALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHV 1162
Query: 687 QAGDTVGEGDLLVELE 702
T+ DL++E+E
Sbjct: 1163 TKDMTLEGDDLILEIE 1178
>gi|106049295 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 377 bits (969), Expect = e-104
Identities = 202/452 (44%), Positives = 291/452 (64%), Gaps = 9/452 (1%)
Query: 35 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGP--APTS 92
K K++VANRGEIA RV R C ++GI+TVAI+S+ D +H + ADEA +G AP
Sbjct: 35 KPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPV- 93
Query: 93 KSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKI 152
++YL++ I++ K+ AVHPGYGFLSE +FA+ V FIGP ++ MGDK+
Sbjct: 94 QAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKV 153
Query: 153 ESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEET 212
E++ +A A V +PG D + EA + G+P++ KA+ GGGG+GMR+ EE
Sbjct: 154 EARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEEL 213
Query: 213 RDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQK 272
+ + + EA ++FG+ L +EKFI+ PRHIE+Q+LGD++GN L L ER+CSIQRR+QK
Sbjct: 214 EENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQK 273
Query: 273 VVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEH 332
VVE AP+ LD + R + +V LA+ V Y +AGTVEFLVD YF+E+N+RLQVEH
Sbjct: 274 VVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEH 333
Query: 333 PVTECITGLDLVQEMIRVAKGYPLRH---KQADIRINGWAVECRVYAEDPYKSFGLPSIG 389
VTE IT +DLV I VA+G L +Q +IRING A++CRV EDP +SF P G
Sbjct: 334 TVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSF-QPDTG 392
Query: 390 RLSQYQEPLHLPGVRVDSGIQ-PGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYV 448
R+ ++ + G+R+D+ G+ IS +YD ++ K+I +G D A +M+ AL +
Sbjct: 393 RIEVFRSGEGM-GIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFR 451
Query: 449 IRGVTHNIALLREVIINSRFVKGDISTKFLSD 480
+RGV NIA L+ V+ N +F+ G + T+F+ +
Sbjct: 452 VRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDE 483
Score = 62.8 bits (151), Expect = 1e-09
Identities = 30/76 (39%), Positives = 46/76 (60%)
Query: 627 KVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHC 686
K +D + +PMPG V+ + V G VA+GQ +CV+ AMKM+ +T+ GTV+ VH
Sbjct: 1103 KALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHV 1162
Query: 687 QAGDTVGEGDLLVELE 702
T+ DL++E+E
Sbjct: 1163 TKDMTLEGDDLILEIE 1178
>gi|106049292 pyruvate carboxylase precursor [Homo sapiens]
Length = 1178
Score = 377 bits (969), Expect = e-104
Identities = 202/452 (44%), Positives = 291/452 (64%), Gaps = 9/452 (1%)
Query: 35 KTFDKILVANRGEIACRVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGP--APTS 92
K K++VANRGEIA RV R C ++GI+TVAI+S+ D +H + ADEA +G AP
Sbjct: 35 KPIKKVMVANRGEIAIRVFRACTELGIRTVAIYSEQDTGQMHRQKADEAYLIGRGLAPV- 93
Query: 93 KSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKI 152
++YL++ I++ K+ AVHPGYGFLSE +FA+ V FIGP ++ MGDK+
Sbjct: 94 QAYLHIPDIIKVAKENNVDAVHPGYGFLSERADFAQACQDAGVRFIGPSPEVVRKMGDKV 153
Query: 153 ESKLLAKKAEVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEET 212
E++ +A A V +PG D + EA + G+P++ KA+ GGGG+GMR+ EE
Sbjct: 154 EARAIAIAAGVPVVPGTDAPITSLHEAHEFSNTYGFPIIFKAAYGGGGRGMRVVHSYEEL 213
Query: 213 RDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQK 272
+ + + EA ++FG+ L +EKFI+ PRHIE+Q+LGD++GN L L ER+CSIQRR+QK
Sbjct: 214 EENYTRAYSEALAAFGNGALFVEKFIEKPRHIEVQILGDQYGNILHLYERDCSIQRRHQK 273
Query: 273 VVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEH 332
VVE AP+ LD + R + +V LA+ V Y +AGTVEFLVD YF+E+N+RLQVEH
Sbjct: 274 VVEIAPAAHLDPQLRTRLTSDSVKLAKQVGYENAGTVEFLVDRHGKHYFIEVNSRLQVEH 333
Query: 333 PVTECITGLDLVQEMIRVAKGYPLRH---KQADIRINGWAVECRVYAEDPYKSFGLPSIG 389
VTE IT +DLV I VA+G L +Q +IRING A++CRV EDP +SF P G
Sbjct: 334 TVTEEITDVDLVHAQIHVAEGRSLPDLGLRQENIRINGCAIQCRVTTEDPARSF-QPDTG 392
Query: 390 RLSQYQEPLHLPGVRVDSGIQ-PGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYV 448
R+ ++ + G+R+D+ G+ IS +YD ++ K+I +G D A +M+ AL +
Sbjct: 393 RIEVFRSGEGM-GIRLDNASAFQGAVISPHYDSLLVKVIAHGKDHPTAATKMSRALAEFR 451
Query: 449 IRGVTHNIALLREVIINSRFVKGDISTKFLSD 480
+RGV NIA L+ V+ N +F+ G + T+F+ +
Sbjct: 452 VRGVKTNIAFLQNVLNNQQFLAGTVDTQFIDE 483
Score = 62.8 bits (151), Expect = 1e-09
Identities = 30/76 (39%), Positives = 46/76 (60%)
Query: 627 KVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHC 686
K +D + +PMPG V+ + V G VA+GQ +CV+ AMKM+ +T+ GTV+ VH
Sbjct: 1103 KALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHV 1162
Query: 687 QAGDTVGEGDLLVELE 702
T+ DL++E+E
Sbjct: 1163 TKDMTLEGDDLILEIE 1178
>gi|38679977 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo
sapiens]
Length = 2346
Score = 248 bits (632), Expect = 2e-65
Identities = 208/745 (27%), Positives = 339/745 (45%), Gaps = 118/745 (15%)
Query: 35 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 83
K +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 116 KVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 175
Query: 84 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 143
V V P + +Y N++ I++ K+ QAV G+G SEN + L + F+GP +
Sbjct: 176 VPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQ 235
Query: 144 AIQAMGDKIESKLLAKKAEVNTIPGF--------------------------DGVVKDAE 177
A+ A+GDKI S ++A+ A + T+P G VKD +
Sbjct: 236 AMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVD 295
Query: 178 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 237
+ ++ A E+GYPVMIKAS GGGGKG+R + ++ + FR E S + + +
Sbjct: 296 DGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS----PIFVMRL 351
Query: 238 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 297
RH+E+Q+L D++GNA+ L R+CS+QRR+QK++EEAP+ M + AV L
Sbjct: 352 AKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKL 411
Query: 298 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 357
A+ V Y SAGTVE+L +FYFLE+N RLQVEHP TE + ++L +++A G PL
Sbjct: 412 AKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPL- 470
Query: 358 HKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ- 393
++ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 471 YRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGF-KPSSGTVQEL 529
Query: 394 -YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 451
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 530 NFRSNKNVWGY---FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD 586
Query: 452 VTHNIALLREVIINSRFVKGDISTKFLSDVY--------PDGFKG------HMLTKSEKN 497
+ L +++ F I T +L + PD G H+ S +N
Sbjct: 587 FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRN 646
Query: 498 QLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSV 557
+ SL L A + +I + + L V ++ V NGS V
Sbjct: 647 SVSNFLHSLERGQVLPAHTLLNTVDVELIYEGV-KYVLKV-TRQSPNSYVVIMNGSCVEV 704
Query: 558 EVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 617
+V L+ L +S DG+ T + E Y++ I +
Sbjct: 705 DVH----------RLSDGGLLLSYDGSSYTTY-MKEEVDR----------YRITIGNKTC 743
Query: 618 AELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGK 677
+ EK E+ SV+RSP G ++ V+ G V GQ IE MKM ++TA +
Sbjct: 744 ------VFEK--ENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVE 795
Query: 678 TGTVKSVHCQAGDTVGEGDLLVELE 702
+G + V + G + G +L +++
Sbjct: 796 SGCIHYVK-RPGAALDPGCVLAKMQ 819
>gi|38679974 acetyl-Coenzyme A carboxylase alpha isoform 4 [Homo
sapiens]
Length = 2268
Score = 248 bits (632), Expect = 2e-65
Identities = 208/745 (27%), Positives = 339/745 (45%), Gaps = 118/745 (15%)
Query: 35 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 83
K +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 38 KVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 97
Query: 84 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 143
V V P + +Y N++ I++ K+ QAV G+G SEN + L + F+GP +
Sbjct: 98 VPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQ 157
Query: 144 AIQAMGDKIESKLLAKKAEVNTIPGF--------------------------DGVVKDAE 177
A+ A+GDKI S ++A+ A + T+P G VKD +
Sbjct: 158 AMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVD 217
Query: 178 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 237
+ ++ A E+GYPVMIKAS GGGGKG+R + ++ + FR E S + + +
Sbjct: 218 DGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS----PIFVMRL 273
Query: 238 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 297
RH+E+Q+L D++GNA+ L R+CS+QRR+QK++EEAP+ M + AV L
Sbjct: 274 AKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKL 333
Query: 298 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 357
A+ V Y SAGTVE+L +FYFLE+N RLQVEHP TE + ++L +++A G PL
Sbjct: 334 AKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPL- 392
Query: 358 HKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ- 393
++ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 393 YRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGF-KPSSGTVQEL 451
Query: 394 -YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 451
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 452 NFRSNKNVWGY---FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD 508
Query: 452 VTHNIALLREVIINSRFVKGDISTKFLSDVY--------PDGFKG------HMLTKSEKN 497
+ L +++ F I T +L + PD G H+ S +N
Sbjct: 509 FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRN 568
Query: 498 QLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSV 557
+ SL L A + +I + + L V ++ V NGS V
Sbjct: 569 SVSNFLHSLERGQVLPAHTLLNTVDVELIYEGV-KYVLKV-TRQSPNSYVVIMNGSCVEV 626
Query: 558 EVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 617
+V L+ L +S DG+ T + E Y++ I +
Sbjct: 627 DVH----------RLSDGGLLLSYDGSSYTTY-MKEEVDR----------YRITIGNKTC 665
Query: 618 AELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGK 677
+ EK E+ SV+RSP G ++ V+ G V GQ IE MKM ++TA +
Sbjct: 666 ------VFEK--ENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVE 717
Query: 678 TGTVKSVHCQAGDTVGEGDLLVELE 702
+G + V + G + G +L +++
Sbjct: 718 SGCIHYVK-RPGAALDPGCVLAKMQ 741
>gi|38679971 acetyl-Coenzyme A carboxylase alpha isoform 3 [Homo
sapiens]
Length = 2288
Score = 248 bits (632), Expect = 2e-65
Identities = 208/745 (27%), Positives = 339/745 (45%), Gaps = 118/745 (15%)
Query: 35 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 83
K +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 58 KVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 117
Query: 84 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 143
V V P + +Y N++ I++ K+ QAV G+G SEN + L + F+GP +
Sbjct: 118 VPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQ 177
Query: 144 AIQAMGDKIESKLLAKKAEVNTIPGF--------------------------DGVVKDAE 177
A+ A+GDKI S ++A+ A + T+P G VKD +
Sbjct: 178 AMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVD 237
Query: 178 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 237
+ ++ A E+GYPVMIKAS GGGGKG+R + ++ + FR E S + + +
Sbjct: 238 DGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS----PIFVMRL 293
Query: 238 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 297
RH+E+Q+L D++GNA+ L R+CS+QRR+QK++EEAP+ M + AV L
Sbjct: 294 AKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKL 353
Query: 298 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 357
A+ V Y SAGTVE+L +FYFLE+N RLQVEHP TE + ++L +++A G PL
Sbjct: 354 AKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPL- 412
Query: 358 HKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ- 393
++ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 413 YRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGF-KPSSGTVQEL 471
Query: 394 -YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 451
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 472 NFRSNKNVWGY---FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD 528
Query: 452 VTHNIALLREVIINSRFVKGDISTKFLSDVY--------PDGFKG------HMLTKSEKN 497
+ L +++ F I T +L + PD G H+ S +N
Sbjct: 529 FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRN 588
Query: 498 QLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSV 557
+ SL L A + +I + + L V ++ V NGS V
Sbjct: 589 SVSNFLHSLERGQVLPAHTLLNTVDVELIYEGV-KYVLKV-TRQSPNSYVVIMNGSCVEV 646
Query: 558 EVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 617
+V L+ L +S DG+ T + E Y++ I +
Sbjct: 647 DVH----------RLSDGGLLLSYDGSSYTTY-MKEEVDR----------YRITIGNKTC 685
Query: 618 AELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGK 677
+ EK E+ SV+RSP G ++ V+ G V GQ IE MKM ++TA +
Sbjct: 686 ------VFEK--ENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVE 737
Query: 678 TGTVKSVHCQAGDTVGEGDLLVELE 702
+G + V + G + G +L +++
Sbjct: 738 SGCIHYVK-RPGAALDPGCVLAKMQ 761
>gi|38679967 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo
sapiens]
Length = 2346
Score = 248 bits (632), Expect = 2e-65
Identities = 208/745 (27%), Positives = 339/745 (45%), Gaps = 118/745 (15%)
Query: 35 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 83
K +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 116 KVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 175
Query: 84 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 143
V V P + +Y N++ I++ K+ QAV G+G SEN + L + F+GP +
Sbjct: 176 VPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQ 235
Query: 144 AIQAMGDKIESKLLAKKAEVNTIPGF--------------------------DGVVKDAE 177
A+ A+GDKI S ++A+ A + T+P G VKD +
Sbjct: 236 AMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVD 295
Query: 178 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 237
+ ++ A E+GYPVMIKAS GGGGKG+R + ++ + FR E S + + +
Sbjct: 296 DGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS----PIFVMRL 351
Query: 238 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 297
RH+E+Q+L D++GNA+ L R+CS+QRR+QK++EEAP+ M + AV L
Sbjct: 352 AKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKL 411
Query: 298 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 357
A+ V Y SAGTVE+L +FYFLE+N RLQVEHP TE + ++L +++A G PL
Sbjct: 412 AKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPL- 470
Query: 358 HKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ- 393
++ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 471 YRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGF-KPSSGTVQEL 529
Query: 394 -YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 451
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 530 NFRSNKNVWGY---FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD 586
Query: 452 VTHNIALLREVIINSRFVKGDISTKFLSDVY--------PDGFKG------HMLTKSEKN 497
+ L +++ F I T +L + PD G H+ S +N
Sbjct: 587 FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRN 646
Query: 498 QLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSV 557
+ SL L A + +I + + L V ++ V NGS V
Sbjct: 647 SVSNFLHSLERGQVLPAHTLLNTVDVELIYEGV-KYVLKV-TRQSPNSYVVIMNGSCVEV 704
Query: 558 EVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 617
+V L+ L +S DG+ T + E Y++ I +
Sbjct: 705 DVH----------RLSDGGLLLSYDGSSYTTY-MKEEVDR----------YRITIGNKTC 743
Query: 618 AELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGK 677
+ EK E+ SV+RSP G ++ V+ G V GQ IE MKM ++TA +
Sbjct: 744 ------VFEK--ENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVE 795
Query: 678 TGTVKSVHCQAGDTVGEGDLLVELE 702
+G + V + G + G +L +++
Sbjct: 796 SGCIHYVK-RPGAALDPGCVLAKMQ 819
>gi|38679960 acetyl-Coenzyme A carboxylase alpha isoform 1 [Homo
sapiens]
Length = 2383
Score = 248 bits (632), Expect = 2e-65
Identities = 208/745 (27%), Positives = 339/745 (45%), Gaps = 118/745 (15%)
Query: 35 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 83
K +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 153 KVIEKVLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 212
Query: 84 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 143
V V P + +Y N++ I++ K+ QAV G+G SEN + L + F+GP +
Sbjct: 213 VPVPGGPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQ 272
Query: 144 AIQAMGDKIESKLLAKKAEVNTIPGF--------------------------DGVVKDAE 177
A+ A+GDKI S ++A+ A + T+P G VKD +
Sbjct: 273 AMWALGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVD 332
Query: 178 EAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEKF 237
+ ++ A E+GYPVMIKAS GGGGKG+R + ++ + FR E S + + +
Sbjct: 333 DGLQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGS----PIFVMRL 388
Query: 238 IDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVAL 297
RH+E+Q+L D++GNA+ L R+CS+QRR+QK++EEAP+ M + AV L
Sbjct: 389 AKQSRHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKL 448
Query: 298 ARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPLR 357
A+ V Y SAGTVE+L +FYFLE+N RLQVEHP TE + ++L +++A G PL
Sbjct: 449 AKMVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPL- 507
Query: 358 HKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ- 393
++ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 508 YRIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGF-KPSSGTVQEL 566
Query: 394 -YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG- 451
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 567 NFRSNKNVWGY---FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGD 623
Query: 452 VTHNIALLREVIINSRFVKGDISTKFLSDVY--------PDGFKG------HMLTKSEKN 497
+ L +++ F I T +L + PD G H+ S +N
Sbjct: 624 FRTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRN 683
Query: 498 QLLAIASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKLHDKVHTVVASNNGSVFSV 557
+ SL L A + +I + + L V ++ V NGS V
Sbjct: 684 SVSNFLHSLERGQVLPAHTLLNTVDVELIYEGV-KYVLKV-TRQSPNSYVVIMNGSCVEV 741
Query: 558 EVDGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLA 617
+V L+ L +S DG+ T + E Y++ I +
Sbjct: 742 DVH----------RLSDGGLLLSYDGSSYTTY-MKEEVDR----------YRITIGNKTC 780
Query: 618 AELNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGK 677
+ EK E+ SV+RSP G ++ V+ G V GQ IE MKM ++TA +
Sbjct: 781 ------VFEK--ENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVE 832
Query: 678 TGTVKSVHCQAGDTVGEGDLLVELE 702
+G + V + G + G +L +++
Sbjct: 833 SGCIHYVK-RPGAALDPGCVLAKMQ 856
>gi|134142062 acetyl-Coenzyme A carboxylase beta [Homo sapiens]
Length = 2458
Score = 245 bits (625), Expect = 1e-64
Identities = 207/743 (27%), Positives = 341/743 (45%), Gaps = 113/743 (15%)
Query: 35 KTFDKILVANRGEIACRVIRTCKKMGIK-----------TVAIHSDVDASSVHVKMADEA 83
+ +K+L+AN G A + +R+ ++ + + D+ A++ ++KMAD
Sbjct: 258 RVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHY 317
Query: 84 VCVGPAPTSKSYLNMDAIMEAIKKTRAQAVHPGYGFLSENKEFARCLAAEDVVFIGPDTH 143
V V P + +Y N++ I++ K+ QAV G+G SEN + L V F+GP +
Sbjct: 318 VPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSE 377
Query: 144 AIQAMGDKIESKLLAKKAEVNTIPG--------------------------FD-GVVKDA 176
A+ A+GDKI S ++A+ +V T+P +D G VKD
Sbjct: 378 AMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKDV 437
Query: 177 EEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIEK 236
+E + A IG+P+MIKAS GGGGKG+R A E+ + F + ++ S + + K
Sbjct: 438 DEGLEAAERIGFPLMIKASEGGGGKGIRKA----ESAEDFPILFRQVQSEIPGSPIFLMK 493
Query: 237 FIDNPRHIEIQVLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMGEQAVA 296
+ RH+E+Q+L D++GNA+ L R+CSIQRR+QK+VEEAP+ M + A+
Sbjct: 494 LAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIR 553
Query: 297 LARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMIRVAKGYPL 356
LA+ V Y SAGTVE+L +F+FLE+N RLQVEHP TE I ++L +++A G PL
Sbjct: 554 LAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPL 613
Query: 357 RHKQADIRI-----------------------NGWAVECRVYAEDPYKSFGLPSIGRLSQ 393
H+ DIR+ G + R+ +E+P + F PS G + +
Sbjct: 614 -HRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGF-KPSSGTVQE 671
Query: 394 --YQEPLHLPGVRVDSGIQPGSDISIYYDPMISKLITYGSDRTEALKRMADALDNYVIRG 451
++ ++ G + + + D ++G +R EA+ M AL IRG
Sbjct: 672 LNFRSSKNVWGY---FSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRG 728
Query: 452 -VTHNIALLREVIINSRFVKGDISTKFLSDVYPDGFKGHMLTKSEKNQL--------LAI 502
+ L ++ F DI T +L + + ++EK + L +
Sbjct: 729 DFRTTVEYLINLLETESFQNNDIDTGWLDYLIAE------KVQAEKPDIMLGVVCGALNV 782
Query: 503 ASSLFVAFQLRAQHFQENSRMPVIKPDIANWELSVKL---HDKVHTVVASNNGSVFSVEV 559
A ++F H E R V+ D + V+L K VA + ++F + +
Sbjct: 783 ADAMFRTCMTDFLHSLE--RGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIM 840
Query: 560 DGSKLNVTSTWNLASPLLSVSVDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAE 619
+G + + L L +S +G T + E Y++ I +
Sbjct: 841 NGCHIEI-DAHRLNDGGLLLSYNGNSYTTY-MKEEVDS----------YRITIGNKTC-- 886
Query: 620 LNKFMLEKVTEDTSSVLRSPMPGVVVAVSVKPGDAVAEGQEICVIEAMKMQNSMTAGKTG 679
+ EK E+ +VLRSP G + +V+ G V G +E MKM ++ + G
Sbjct: 887 ----VFEK--ENDPTVLRSPSAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERG 940
Query: 680 TVKSVHCQAGDTVGEGDLLVELE 702
VK + + G + G ++ LE
Sbjct: 941 RVKYIK-RPGAVLEAGCVVARLE 962
>gi|18105007 carbamoylphosphate synthetase 2/aspartate
transcarbamylase/dihydroorotase [Homo sapiens]
Length = 2225
Score = 62.8 bits (151), Expect = 1e-09
Identities = 71/316 (22%), Positives = 133/316 (42%), Gaps = 28/316 (8%)
Query: 51 RVIRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRA 110
+ I+ K+ I+T+ I+ ++ +AD+ + P + Y + + I+ R
Sbjct: 418 QAIKALKEENIQTLLINPNIATVQTSQGLADKVYFL---PITPHY-----VTQVIRNERP 469
Query: 111 QAVHPGYG---FLSENKEFARC--LAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNT 165
V +G L+ E + LA V +G I+ D+ A+ AE+
Sbjct: 470 DGVLLTFGGQTALNCGVELTKAGVLARYGVRVLGTPVETIELTEDR--RAFAARMAEIGE 527
Query: 166 IPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAAS 225
E+A A +GYPV+++A+ GG G A + EE LS+ A +
Sbjct: 528 HVAPSEAANSLEQAQAAAERLGYPVLVRAAFALGGLGSGFASNREE------LSALVAPA 581
Query: 226 SFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERE----CSIQRRNQKVVEEAPSIF 281
++L++K + + IE +V+ D +GN + + E I VV APS
Sbjct: 582 FAHTSQVLVDKSLKGWKEIEYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVV--APSQT 639
Query: 282 LDAETRRAMGEQAVALARAVKYSSAGTVEFLVD-SKKNFYFLEMNTRLQVEHPVTECITG 340
L+ + + + A+ + + + V++ ++ + +Y +E+N RL + TG
Sbjct: 640 LNDREYQLLRQTAIKVTQHLGIVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATG 699
Query: 341 LDLVQEMIRVAKGYPL 356
L ++A G PL
Sbjct: 700 YPLAYVAAKLALGIPL 715
Score = 46.6 bits (109), Expect = 8e-05
Identities = 65/305 (21%), Positives = 117/305 (38%), Gaps = 23/305 (7%)
Query: 53 IRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQA 112
I+ +KMG KT+ ++ + + S M D ++ + +M+ + +
Sbjct: 959 IQQLRKMGYKTIMVNYNPETVSTDYDMCDRLYF--------DEISFEVVMDIYELENPEG 1010
Query: 113 VHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGV 172
V G N A L + +G AI + ++ + L ++ +
Sbjct: 1011 VILSMGGQLPN-NMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRE-- 1067
Query: 173 VKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRL 232
+ D E A + + +GYP +++ S G M +A+ D + R S AA S + +
Sbjct: 1068 LSDLESARQFCQTVGYPCVVRPSYVLSGAAMNVAYTDGDLE---RFLSSAAAVS-KEHPV 1123
Query: 233 LIEKFIDNPRHIEIQ-VLGDKHGNALWLNERECSIQRRNQKVVEEAPSIFLDAETRRAMG 291
+I KFI + I++ V D A+ ++E + + P + A+T
Sbjct: 1124 VISKFIQEAKEIDVDAVASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTL---- 1179
Query: 292 EQAVALARAVKYSSAGTVEF---LVDSKKNFYFLEMNTRLQVEHPVTECITGLDLVQEMI 348
E+ A+ AV T F L+ +E N R+ P G+DLV
Sbjct: 1180 ERIKAIVHAVGQELQVTGPFNLQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALAT 1239
Query: 349 RVAKG 353
RV G
Sbjct: 1240 RVIMG 1244
>gi|169790915 carbamoyl-phosphate synthetase 1 isoform a precursor
[Homo sapiens]
Length = 1506
Score = 56.2 bits (134), Expect = 1e-07
Identities = 77/320 (24%), Positives = 138/320 (43%), Gaps = 33/320 (10%)
Query: 51 RVIRTCKKMGIKTVAIH---SDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKK 107
+ ++ K+ +KTV ++ + V + V +K AD + P + E IK
Sbjct: 453 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITP--------QFVTEVIKA 504
Query: 108 TRAQAVHPGYG---FLSENKE-FARCLAAE-DVVFIGPDTHAIQAMGDKIESKLLAKKA- 161
+ + G G L+ E F R + E V +G +I A D+ +L + K
Sbjct: 505 EQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDR---QLFSDKLN 561
Query: 162 EVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQ 221
E+N V+ E+A++ A IGYPVMI+++ GG G I + E D LS++
Sbjct: 562 EINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMD---LSTK 618
Query: 222 EAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWL----NERECSIQRRNQKVVEEA 277
A + +++L+EK + + IE +V+ D N + + N + + VV A
Sbjct: 619 AFAMT---NQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--A 673
Query: 278 PSIFLDAETRRAMGEQAVALARAVKYSSAGTVEF-LVDSKKNFYFLEMNTRLQVEHPVTE 336
P+ L + + ++ + R + ++F L + + +E+N RL +
Sbjct: 674 PAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALAS 733
Query: 337 CITGLDLVQEMIRVAKGYPL 356
TG L ++A G PL
Sbjct: 734 KATGYPLAFIAAKIALGIPL 753
Score = 43.9 bits (102), Expect = 5e-04
Identities = 60/311 (19%), Positives = 117/311 (37%), Gaps = 35/311 (11%)
Query: 53 IRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQA 112
IRT +++G KTV ++ + + S D+ L+++ I++ +
Sbjct: 1006 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 1057
Query: 113 VHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGV 172
G N A L V +G I D+ + + +V P
Sbjct: 1058 CIISVGGQIPNN-LAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPW--KA 1114
Query: 173 VKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRL 232
V EA+ A+ + YP +++ S G M + + ++E + +EA + +
Sbjct: 1115 VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFL----EEATRVSQEHPV 1170
Query: 233 LIEKFIDNPRHIEIQVLG----------DKHGNALWLNERECSIQRRNQKVVEEAPSIFL 282
++ KF++ R +E+ +G +H ++ + ++ Q + + A
Sbjct: 1171 VLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVK 1230
Query: 283 DAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD 342
DA TR+ +A+A S V+FLV + +E N R P G+D
Sbjct: 1231 DA-TRK--------IAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVD 1280
Query: 343 LVQEMIRVAKG 353
+ +V G
Sbjct: 1281 FIDVATKVMIG 1291
>gi|21361331 carbamoyl-phosphate synthetase 1 isoform b precursor
[Homo sapiens]
Length = 1500
Score = 56.2 bits (134), Expect = 1e-07
Identities = 77/320 (24%), Positives = 138/320 (43%), Gaps = 33/320 (10%)
Query: 51 RVIRTCKKMGIKTVAIH---SDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKK 107
+ ++ K+ +KTV ++ + V + V +K AD + P + E IK
Sbjct: 447 QAVKAMKEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITP--------QFVTEVIKA 498
Query: 108 TRAQAVHPGYG---FLSENKE-FARCLAAE-DVVFIGPDTHAIQAMGDKIESKLLAKKA- 161
+ + G G L+ E F R + E V +G +I A D+ +L + K
Sbjct: 499 EQPDGLILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDR---QLFSDKLN 555
Query: 162 EVNTIPGFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQ 221
E+N V+ E+A++ A IGYPVMI+++ GG G I + E D LS++
Sbjct: 556 EINEKIAPSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMD---LSTK 612
Query: 222 EAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWL----NERECSIQRRNQKVVEEA 277
A + +++L+EK + + IE +V+ D N + + N + + VV A
Sbjct: 613 AFAMT---NQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--A 667
Query: 278 PSIFLDAETRRAMGEQAVALARAVKYSSAGTVEF-LVDSKKNFYFLEMNTRLQVEHPVTE 336
P+ L + + ++ + R + ++F L + + +E+N RL +
Sbjct: 668 PAQTLSNAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALAS 727
Query: 337 CITGLDLVQEMIRVAKGYPL 356
TG L ++A G PL
Sbjct: 728 KATGYPLAFIAAKIALGIPL 747
Score = 43.9 bits (102), Expect = 5e-04
Identities = 60/311 (19%), Positives = 117/311 (37%), Gaps = 35/311 (11%)
Query: 53 IRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQA 112
IRT +++G KTV ++ + + S D+ L+++ I++ +
Sbjct: 1000 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 1051
Query: 113 VHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGV 172
G N A L V +G I D+ + + +V P
Sbjct: 1052 CIISVGGQIPNN-LAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPW--KA 1108
Query: 173 VKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRL 232
V EA+ A+ + YP +++ S G M + + ++E + +EA + +
Sbjct: 1109 VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFL----EEATRVSQEHPV 1164
Query: 233 LIEKFIDNPRHIEIQVLG----------DKHGNALWLNERECSIQRRNQKVVEEAPSIFL 282
++ KF++ R +E+ +G +H ++ + ++ Q + + A
Sbjct: 1165 VLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVK 1224
Query: 283 DAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD 342
DA TR+ +A+A S V+FLV + +E N R P G+D
Sbjct: 1225 DA-TRK--------IAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVD 1274
Query: 343 LVQEMIRVAKG 353
+ +V G
Sbjct: 1275 FIDVATKVMIG 1285
>gi|170295797 carbamoyl-phosphate synthetase 1 isoform c [Homo
sapiens]
Length = 1049
Score = 54.3 bits (129), Expect = 4e-07
Identities = 77/314 (24%), Positives = 135/314 (42%), Gaps = 33/314 (10%)
Query: 57 KKMGIKTVAIH---SDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQAV 113
K+ +KTV ++ + V + V +K AD + P + E IK + +
Sbjct: 2 KEENVKTVLMNPNIASVQTNEVGLKQADTVYFLPITP--------QFVTEVIKAEQPDGL 53
Query: 114 HPGYG---FLSENKE-FARCLAAE-DVVFIGPDTHAIQAMGDKIESKLLAKKA-EVNTIP 167
G G L+ E F R + E V +G +I A D+ +L + K E+N
Sbjct: 54 ILGMGGQTALNCGVELFKRGVLKEYGVKVLGTSVESIMATEDR---QLFSDKLNEINEKI 110
Query: 168 GFDGVVKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSF 227
V+ E+A++ A IGYPVMI+++ GG G I + E D LS++ A +
Sbjct: 111 APSFAVESIEDALKAADTIGYPVMIRSAYALGGLGSGICPNRETLMD---LSTKAFAMT- 166
Query: 228 GDDRLLIEKFIDNPRHIEIQVLGDKHGNALWL----NERECSIQRRNQKVVEEAPSIFLD 283
+++L+EK + + IE +V+ D N + + N + + VV AP+ L
Sbjct: 167 --NQILVEKSVTGWKEIEYEVVRDADDNCVTVCNMENVDAMGVHTGDSVVV--APAQTLS 222
Query: 284 AETRRAMGEQAVALARAVKYSSAGTVEF-LVDSKKNFYFLEMNTRLQVEHPVTECITGLD 342
+ + ++ + R + ++F L + + +E+N RL + TG
Sbjct: 223 NAEFQMLRRTSINVVRHLGIVGECNIQFALHPTSMEYCIIEVNARLSRSSALASKATGYP 282
Query: 343 LVQEMIRVAKGYPL 356
L ++A G PL
Sbjct: 283 LAFIAAKIALGIPL 296
Score = 43.9 bits (102), Expect = 5e-04
Identities = 60/311 (19%), Positives = 117/311 (37%), Gaps = 35/311 (11%)
Query: 53 IRTCKKMGIKTVAIHSDVDASSVHVKMADEAVCVGPAPTSKSYLNMDAIMEAIKKTRAQA 112
IRT +++G KTV ++ + + S D+ L+++ I++ +
Sbjct: 549 IRTLRQLGKKTVVVNCNPETVSTDFDECDKLYF--------EELSLERILDIYHQEACGG 600
Query: 113 VHPGYGFLSENKEFARCLAAEDVVFIGPDTHAIQAMGDKIESKLLAKKAEVNTIPGFDGV 172
G N A L V +G I D+ + + +V P
Sbjct: 601 CIISVGGQIPNN-LAVPLYKNGVKIMGTSPLQIDRAEDRSIFSAVLDELKVAQAPW--KA 657
Query: 173 VKDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRL 232
V EA+ A+ + YP +++ S G M + + ++E + +EA + +
Sbjct: 658 VNTLNEALEFAKSVDYPCLLRPSYVLSGSAMNVVFSEDEMKKFL----EEATRVSQEHPV 713
Query: 233 LIEKFIDNPRHIEIQVLG----------DKHGNALWLNERECSIQRRNQKVVEEAPSIFL 282
++ KF++ R +E+ +G +H ++ + ++ Q + + A
Sbjct: 714 VLTKFVEGAREVEMDAVGKDGRVISHAISEHVEDAGVHSGDATLMLPTQTISQGAIEKVK 773
Query: 283 DAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLEMNTRLQVEHPVTECITGLD 342
DA TR+ +A+A S V+FLV + +E N R P G+D
Sbjct: 774 DA-TRK--------IAKAFAISGPFNVQFLVKG-NDVLVIECNLRASRSFPFVSKTLGVD 823
Query: 343 LVQEMIRVAKG 353
+ +V G
Sbjct: 824 FIDVATKVMIG 834
>gi|110671329 dihydrolipoamide branched chain transacylase precursor
[Homo sapiens]
Length = 482
Score = 33.1 bits (74), Expect = 0.90
Identities = 16/54 (29%), Positives = 29/54 (53%)
Query: 649 VKPGDAVAEGQEICVIEAMKMQNSMTAGKTGTVKSVHCQAGDTVGEGDLLVELE 702
VK GD V++ IC +++ K ++T+ G +K ++ D G LV++E
Sbjct: 86 VKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNLDDIAYVGKPLVDIE 139
>gi|212549738 anaphase-promoting complex subunit 7 isoform b [Homo
sapiens]
Length = 537
Score = 32.3 bits (72), Expect = 1.5
Identities = 23/99 (23%), Positives = 46/99 (46%), Gaps = 1/99 (1%)
Query: 268 RRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLE-MNT 326
++ Q +V A S+F D E R A+ + +AL + S V + + + + +
Sbjct: 75 QKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPS 134
Query: 327 RLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIRI 365
++V++ + EC T L ++ I + G P R + I +
Sbjct: 135 EIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINM 173
>gi|212549736 anaphase-promoting complex subunit 7 isoform a [Homo
sapiens]
Length = 599
Score = 32.3 bits (72), Expect = 1.5
Identities = 23/99 (23%), Positives = 46/99 (46%), Gaps = 1/99 (1%)
Query: 268 RRNQKVVEEAPSIFLDAETRRAMGEQAVALARAVKYSSAGTVEFLVDSKKNFYFLE-MNT 326
++ Q +V A S+F D E R A+ + +AL + S V + + + + +
Sbjct: 75 QKYQLLVYHADSLFHDKEYRNAVSKYTMALQQKKALSKTSKVRPSTGNSASTPQSQCLPS 134
Query: 327 RLQVEHPVTECITGLDLVQEMIRVAKGYPLRHKQADIRI 365
++V++ + EC T L ++ I + G P R + I +
Sbjct: 135 EIEVKYKMAECYTMLKQDKDAIAILDGIPSRQRTPKINM 173
>gi|28416899 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 2 [Homo
sapiens]
Length = 433
Score = 30.4 bits (67), Expect = 5.8
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 177 EEAVRIAREIGYPVMI-KASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIE 235
EEA +P ++ KAS GKG+ +A EE + QE A + ++IE
Sbjct: 131 EEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIE 190
Query: 236 KFID 239
+ +D
Sbjct: 191 ELLD 194
>gi|4503915 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 30.4 bits (67), Expect = 5.8
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 177 EEAVRIAREIGYPVMI-KASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIE 235
EEA +P ++ KAS GKG+ +A EE + QE A + ++IE
Sbjct: 131 EEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIE 190
Query: 236 KFID 239
+ +D
Sbjct: 191 ELLD 194
>gi|209869995 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 30.4 bits (67), Expect = 5.8
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 177 EEAVRIAREIGYPVMI-KASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIE 235
EEA +P ++ KAS GKG+ +A EE + QE A + ++IE
Sbjct: 131 EEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIE 190
Query: 236 KFID 239
+ +D
Sbjct: 191 ELLD 194
>gi|209869993 phosphoribosylglycinamide formyltransferase,
phosphoribosylglycinamide synthetase,
phosphoribosylaminoimidazole synthetase isoform 1 [Homo
sapiens]
Length = 1010
Score = 30.4 bits (67), Expect = 5.8
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 1/64 (1%)
Query: 177 EEAVRIAREIGYPVMI-KASAGGGGKGMRIAWDDEETRDGFRLSSQEAASSFGDDRLLIE 235
EEA +P ++ KAS GKG+ +A EE + QE A + ++IE
Sbjct: 131 EEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAFGAAGETIVIE 190
Query: 236 KFID 239
+ +D
Sbjct: 191 ELLD 194
>gi|157885806 chromosome 12 open reading frame 51 [Homo sapiens]
Length = 3996
Score = 30.4 bits (67), Expect = 5.8
Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 6/69 (8%)
Query: 581 VDGTQRTVQCLSREAGGNMSIQFLGTVYKVNILTRLAAELNKFMLEKVTEDTSSVLRSPM 640
VD ++TV+ L E GG +L T+ + E NKF ++KV + + V RSP
Sbjct: 2291 VDIARQTVEFLYEENGGIPRDLYLPTIEDIK------DEANKFTIDKVRKGLTVVTRSPD 2344
Query: 641 PGVVVAVSV 649
V + +V
Sbjct: 2345 SNNVASSAV 2353
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 30.0 bits (66), Expect = 7.6
Identities = 17/42 (40%), Positives = 22/42 (52%), Gaps = 6/42 (14%)
Query: 46 GEIACRVIRTCKKMGIKTVAIHSDVDASSV------HVKMAD 81
GEIA ++R + + K IH DV S+V HVKM D
Sbjct: 172 GEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCD 213
>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
kinase 3 [Homo sapiens]
Length = 198
Score = 30.0 bits (66), Expect = 7.6
Identities = 17/42 (40%), Positives = 22/42 (52%), Gaps = 6/42 (14%)
Query: 46 GEIACRVIRTCKKMGIKTVAIHSDVDASSV------HVKMAD 81
GEIA ++R + + K IH DV S+V HVKM D
Sbjct: 59 GEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCD 100
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 30.0 bits (66), Expect = 7.6
Identities = 17/42 (40%), Positives = 22/42 (52%), Gaps = 6/42 (14%)
Query: 46 GEIACRVIRTCKKMGIKTVAIHSDVDASSV------HVKMAD 81
GEIA ++R + + K IH DV S+V HVKM D
Sbjct: 138 GEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCD 179
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 30.0 bits (66), Expect = 7.6
Identities = 17/42 (40%), Positives = 22/42 (52%), Gaps = 6/42 (14%)
Query: 46 GEIACRVIRTCKKMGIKTVAIHSDVDASSV------HVKMAD 81
GEIA ++R + + K IH DV S+V HVKM D
Sbjct: 167 GEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCD 208
>gi|4505941 DNA directed RNA polymerase II polypeptide B [Homo
sapiens]
Length = 1174
Score = 30.0 bits (66), Expect = 7.6
Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 21/85 (24%)
Query: 208 DDEETRDGFRLSSQEAASSFGDDRLLIEKFIDNPRHIEIQVLGDKHGNALWLNERECSIQ 267
DDE T D ++ + SS+ D++ L+ + +D+ IQ
Sbjct: 14 DDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEF---------------------IQ 52
Query: 268 RRNQKVVEEAPSIFLDAETRRAMGE 292
Q++VE+AP I L AE + A GE
Sbjct: 53 MSVQRIVEDAPPIDLQAEAQHASGE 77
>gi|164663810 ribosomal modification protein rimK-like family member
A [Homo sapiens]
Length = 391
Score = 29.6 bits (65), Expect = 10.0
Identities = 13/41 (31%), Positives = 23/41 (56%)
Query: 174 KDAEEAVRIAREIGYPVMIKASAGGGGKGMRIAWDDEETRD 214
+D + + A +GYPV++K++ G GK + +A D D
Sbjct: 135 EDFSKMIDEAEPLGYPVVVKSTRGHRGKAVFLARDKHHLSD 175
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,289,886
Number of Sequences: 37866
Number of extensions: 979500
Number of successful extensions: 2509
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2421
Number of HSP's gapped (non-prelim): 58
length of query: 702
length of database: 18,247,518
effective HSP length: 109
effective length of query: 593
effective length of database: 14,120,124
effective search space: 8373233532
effective search space used: 8373233532
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.