Guide to the Human Genome
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Search of human proteins with 189083786

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189083786 leukemia inhibitory factor receptor precursor
[Homo sapiens]
         (1097 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504993 leukemia inhibitory factor receptor precursor [Homo s...  2254   0.0  
gi|189083786 leukemia inhibitory factor receptor precursor [Homo...  2254   0.0  
gi|4557040 oncostatin M receptor [Homo sapiens]                       411   e-114
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ...   187   5e-47
gi|115430248 gp130-like monocyte receptor [Homo sapiens]              135   2e-31
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]   126   1e-28
gi|27437045 colony stimulating factor 3 receptor isoform d precu...   102   3e-21
gi|24496783 colony stimulating factor 3 receptor isoform c precu...   102   3e-21
gi|4503081 colony stimulating factor 3 receptor isoform a precur...   102   3e-21
gi|27437042 colony stimulating factor 3 receptor isoform b precu...    96   1e-19
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ...    84   1e-15
gi|51093381 leptin receptor isoform 3 [Homo sapiens]                   74   6e-13
gi|51093379 leptin receptor isoform 2 [Homo sapiens]                   74   6e-13
gi|40254464 leptin receptor isoform 1 [Homo sapiens]                   74   6e-13
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...    68   5e-11
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...    68   5e-11
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...    67   7e-11
gi|81158224 neuronal cell adhesion molecule isoform B precursor ...    65   4e-10
gi|148806908 fibronectin type III domain containing 1 [Homo sapi...    64   1e-09
gi|27894376 cell adhesion molecule with homology to L1CAM precur...    64   1e-09
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]              64   1e-09
gi|81158226 neuronal cell adhesion molecule isoform A precursor ...    63   1e-09
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...    63   2e-09
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...    63   2e-09
gi|24430212 interleukin 23 receptor precursor [Homo sapiens]           62   2e-09
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...    59   3e-08
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...    59   3e-08
gi|75709184 contactin 3 [Homo sapiens]                                 58   4e-08
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom...    58   6e-08
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...    55   3e-07

>gi|4504993 leukemia inhibitory factor receptor precursor [Homo
            sapiens]
          Length = 1097

 Score = 2254 bits (5840), Expect = 0.0
 Identities = 1097/1097 (100%), Positives = 1097/1097 (100%)

Query: 1    MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL 60
            MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL
Sbjct: 1    MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL 60

Query: 61   QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS 120
            QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS
Sbjct: 61   QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS 120

Query: 121  STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE 180
            STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE
Sbjct: 121  STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE 180

Query: 181  SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP 240
            SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP
Sbjct: 181  SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP 240

Query: 241  VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK 300
            VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK
Sbjct: 241  VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK 300

Query: 301  IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360
            IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA
Sbjct: 301  IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360

Query: 361  LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ 420
            LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ
Sbjct: 361  LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ 420

Query: 421  STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR 480
            STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR
Sbjct: 421  STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR 480

Query: 481  NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD 540
            NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD
Sbjct: 481  NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD 540

Query: 541  TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK 600
            TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK
Sbjct: 541  TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK 600

Query: 601  NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK 660
            NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK
Sbjct: 601  NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK 660

Query: 661  WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE 720
            WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE
Sbjct: 661  WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE 720

Query: 721  ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR 780
            ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR
Sbjct: 721  ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR 780

Query: 781  SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI 840
            SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI
Sbjct: 781  SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI 840

Query: 841  LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM 900
            LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM
Sbjct: 841  LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM 900

Query: 901  NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN 960
            NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN
Sbjct: 901  NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN 960

Query: 961  PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE 1020
            PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE
Sbjct: 961  PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE 1020

Query: 1021 DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS 1080
            DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS
Sbjct: 1021 DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS 1080

Query: 1081 NGGGWSFTNFFQNKPND 1097
            NGGGWSFTNFFQNKPND
Sbjct: 1081 NGGGWSFTNFFQNKPND 1097


>gi|189083786 leukemia inhibitory factor receptor precursor [Homo
            sapiens]
          Length = 1097

 Score = 2254 bits (5840), Expect = 0.0
 Identities = 1097/1097 (100%), Positives = 1097/1097 (100%)

Query: 1    MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL 60
            MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL
Sbjct: 1    MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL 60

Query: 61   QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS 120
            QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS
Sbjct: 61   QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS 120

Query: 121  STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE 180
            STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE
Sbjct: 121  STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE 180

Query: 181  SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP 240
            SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP
Sbjct: 181  SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP 240

Query: 241  VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK 300
            VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK
Sbjct: 241  VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK 300

Query: 301  IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360
            IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA
Sbjct: 301  IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360

Query: 361  LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ 420
            LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ
Sbjct: 361  LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ 420

Query: 421  STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR 480
            STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR
Sbjct: 421  STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR 480

Query: 481  NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD 540
            NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD
Sbjct: 481  NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD 540

Query: 541  TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK 600
            TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK
Sbjct: 541  TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK 600

Query: 601  NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK 660
            NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK
Sbjct: 601  NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK 660

Query: 661  WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE 720
            WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE
Sbjct: 661  WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE 720

Query: 721  ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR 780
            ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR
Sbjct: 721  ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR 780

Query: 781  SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI 840
            SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI
Sbjct: 781  SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI 840

Query: 841  LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM 900
            LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM
Sbjct: 841  LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM 900

Query: 901  NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN 960
            NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN
Sbjct: 901  NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN 960

Query: 961  PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE 1020
            PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE
Sbjct: 961  PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE 1020

Query: 1021 DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS 1080
            DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS
Sbjct: 1021 DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS 1080

Query: 1081 NGGGWSFTNFFQNKPND 1097
            NGGGWSFTNFFQNKPND
Sbjct: 1081 NGGGWSFTNFFQNKPND 1097


>gi|4557040 oncostatin M receptor [Homo sapiens]
          Length = 979

 Score =  411 bits (1056), Expect = e-114
 Identities = 264/806 (32%), Positives = 421/806 (52%), Gaps = 54/806 (6%)

Query: 135 IPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTL 194
           +P TP  L +S + +  +L+L+W      +     ++++I++ R E+  ++ +  ++TT+
Sbjct: 30  LPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTV 89

Query: 195 NGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTK- 253
                LH WSW S++PLECA HFV I+  +D+  F     WS+WS  + +S + DS  + 
Sbjct: 90  KWNQVLH-WSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVS-VQDSTGQD 147

Query: 254 ---VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPL----IH---LDGENVAIKIRN 303
              VFP+DK++  G+++T C VS+      +  + +C L    IH   LD    A  + +
Sbjct: 148 ILFVFPKDKLVEEGTNVTICYVSRN-----IQNNVSCYLEGKQIHGEQLDPHVTAFNLNS 202

Query: 304 ISVSASSGTNVVF-----TTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRV 358
           +    + GTN+          + + G V+F     + P+  +CET D K + C+W+PG  
Sbjct: 203 VPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTD 262

Query: 359 TALVGPR--ATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPL 416
           TAL   +  + SYTL ESFSG+       +  T++++        +QE YNFTL A N L
Sbjct: 263 TALGWSKQPSQSYTLFESFSGE------KKLCTHKNWCNWQITQDSQETYNFTLIAENYL 316

Query: 417 GRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSV 476
            +    IL N+T +VY   P S   +++N+T   ++W +        +LC+IE+     +
Sbjct: 317 RKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKM 376

Query: 477 QEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQHLTTEASP 535
             Q NV+IK   N  Y   L +L P T Y  R+RC+  + FWKWS+WS +    T EA+P
Sbjct: 377 M-QYNVSIK--VNGEYF--LSELEPATEYMARVRCADASHFWKWSEWSGQN-FTTLEAAP 430

Query: 536 SKGPDTWREWSSDGKN--LIIYWKPLPINEANGKILSYNVSCSSDEETQS--LSEIPDPQ 591
           S+ PD WR  S +  N  + ++WKPL    ANGKIL YNV   + ++  S  L  IP P 
Sbjct: 431 SEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPA 490

Query: 592 HKAEIRLDKNDYIISVVAKNSVGSSPPSKIA-SMEIPNDDLKIEQVVGMGKGILLTWHYD 650
           +  ++ LD+  Y I V+A NSVG+SP S I  S +  N +++ E++ G   G  L+W   
Sbjct: 491 NSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQ 550

Query: 651 PNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQ 710
           P     YV+ WC+ ++       W+ V  N+T TVI +D FRPG+RY+F +YG   +   
Sbjct: 551 PGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIA 610

Query: 711 -LLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERD 769
            LL    GY +ELAP   P+  V+  ++ S  + W+D   E   GF++GY  Y     R 
Sbjct: 611 CLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQ 670

Query: 770 TS---KMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSM- 825
                +  VL  G    K K I +  +K L + +L+ ++ Y   +  +T  G GP  +  
Sbjct: 671 CHPRFEKAVLSDGSECCKYK-IDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFT 729

Query: 826 YVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQ 885
            V T +    ++I IL+P+   V+   +  ++CY K +WIKET YPDIP+P     L   
Sbjct: 730 KVTTPDEHSSMLIHILLPMVFCVL---LIMVMCYLKSQWIKETCYPDIPDPYKSSILSLI 786

Query: 886 KSVCEGSSALKTLEMNPCTPNNVEVL 911
           K   + +  L  + ++ C P+ +EV+
Sbjct: 787 K--FKENPHLIIMNVSDCIPDAIEVV 810


>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
           [Homo sapiens]
          Length = 918

 Score =  187 bits (475), Expect = 5e-47
 Identities = 166/667 (24%), Positives = 282/667 (42%), Gaps = 67/667 (10%)

Query: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313
           + P+  V+ + S+ T  CV +EK +     H N   I     +  I     ++   + ++
Sbjct: 31  ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88

Query: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355
           V FT                   E N++G  I +G PP+ P+ L+C  ++ K++ C W+ 
Sbjct: 89  VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148

Query: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413
           GR T L     T++TL   + + K+   K + + PT+ +         N E++   + A 
Sbjct: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201

Query: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470
           N LG+  S  I  +   KV P+ P +  V   +  S+ +KL+W  P   + I     I+ 
Sbjct: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261

Query: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528
           + K  S   Q          SS+ V    L P+T Y FRIRC  E     WS WS +   
Sbjct: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319

Query: 529 LTTEASPSKGPDTWRE----WSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSL 584
           +T E  PSK P  W +     +   + + + WK LP  EANGKIL Y V+ +       L
Sbjct: 320 ITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--RWKSHL 377

Query: 585 SEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKG-- 642
                   K  + L  + Y+ ++  +N VG    S  A + IP  D +    V   K   
Sbjct: 378 QNYTVNATKLTVNLTNDRYLATLTVRNLVGK---SDAAVLTIPACDFQATHPVMDLKAFP 434

Query: 643 ----ILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYN 698
               + + W         Y+++WC  S   PC+ DW++       T +  +       Y 
Sbjct: 435 KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN-LAESKCYL 493

Query: 699 FFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRG 758
             +      G     S+  Y+++  P   P    +    +  +++W+ +PV+   GF+R 
Sbjct: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRN 553

Query: 759 YLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGG 818
           Y  ++          R +    + + V    D S     ++ L   T Y + + AYTD G
Sbjct: 554 YTIFY----------RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599

Query: 819 VGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSIL-CYRKREWIKETFYPDIPNPE 877
                     T + + G I AI++PV +A ++  +  +L C+ KR+ IK+  +P++P+P 
Sbjct: 600 GKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPS 659

Query: 878 NCKALQF 884
                Q+
Sbjct: 660 KSHIAQW 666


>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
          Length = 764

 Score =  135 bits (340), Expect = 2e-31
 Identities = 130/569 (22%), Positives = 235/569 (41%), Gaps = 55/569 (9%)

Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFS-GKYVRLKRAEAPTNE 391
           P  P+ ++C  +  K + C+W+PG+ T+      T YT+  +++ G+        + T+E
Sbjct: 54  PAKPENISCVYYYRKNLTCTWSPGKETSY-----TQYTVKRTYAFGEKHDNCTTNSSTSE 108

Query: 392 SYQLLFQMLPNQEI---YNFTLNAHNPLGRSQSTILVNITEKVYPHTPTS-FKVKDINST 447
           +       LP   I   Y   + A N  G  +S +     E +    P   F+VK +   
Sbjct: 109 NRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGI 168

Query: 448 A--VKLSW---HLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPY 502
              +++ W    L    + + +        S S  E      +  +N +Y   L  L P+
Sbjct: 169 KRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTY--NLTGLQPF 226

Query: 503 TLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWR---EWSSDGKNLI-IYWKP 558
           T Y   +RC+ +    WS WS +K  +T E +P  G + WR      +DG+  + + WK 
Sbjct: 227 TEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPC-GLELWRVLKPAEADGRRPVRLLWKK 285

Query: 559 LPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPP 618
                   K L YN+    +  T     +     + E+ L    + +S+++ NS+G SP 
Sbjct: 286 ARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSP- 344

Query: 619 SKIASMEIPNDDLKIEQVVGMGKG------ILLTWHYDPNMTCDYVIKWCNSSRSEPCLM 672
             +A++ IP    K  Q + + +       +++ W         ++I+W     SEP  +
Sbjct: 345 --VATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTL 402

Query: 673 DWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTV 732
            W  V S +T   I+ D+ +P   YN  +Y   +       S+  Y +E  P   P   V
Sbjct: 403 SWESV-SQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKV 461

Query: 733 EDTSADSILVKWEDIPVEELRGFLRGYLFYF----GKGERDTSKMRVLESGRSDIKVKNI 788
           E+    ++ + W++IP  E +G +  Y  ++    GKG   T    +L+ G         
Sbjct: 462 ENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYG--------- 512

Query: 789 TDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAV 848
                    +  L+ KTSY + + A T  G     S+   T   SV  II I   +   +
Sbjct: 513 ---------LESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGL 563

Query: 849 IVGVVTSILC-YRKREWIKETFYPDIPNP 876
           ++ ++ ++    +K   +    +P +PNP
Sbjct: 564 LILIILTVAYGLKKPNKLTHLCWPTVPNP 592


>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
          Length = 862

 Score =  126 bits (316), Expect = 1e-28
 Identities = 156/596 (26%), Positives = 251/596 (42%), Gaps = 70/596 (11%)

Query: 319 EDNIFGTVIFAGYPPDTPQQLNC-ETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSG 377
           E  I G  IF G  P+ PQ L+C +  +   + C+W  GR T L     T YTL  S   
Sbjct: 110 EIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLY----TEYTLQLSGPK 165

Query: 378 KYVRLKRAEAPTNESYQLLFQMLPNQEIYNFT--LNAHNPLGRSQST-ILVNITEKVYPH 434
                K+ +    +       + P     NFT  + A N LG S S        + V P 
Sbjct: 166 NLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPL 225

Query: 435 TPTSFKVKDINSTAVK--LSWHLPGNFAKINFLCEIEIKKSNS-VQEQRNVT-IKGVENS 490
            P   ++K   ++  +  L W   G    +  L  +  + SNS +    NVT  KG  + 
Sbjct: 226 PPWDIRIKFQKASVSRCTLYWRDEG----LVLLNRLRYRPSNSRLWNMVNVTKAKGRHD- 280

Query: 491 SYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW---REWS 546
                L  L P+T Y F+I      +   WS WS   +  T E  P+   D W   R   
Sbjct: 281 -----LLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHID 335

Query: 547 SDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSE-IPDPQHKAEIRLDKNDYII 605
              + + ++WK L ++EA GKIL Y V+       +++++ I        +     ++ +
Sbjct: 336 YSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAV 395

Query: 606 SVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGK----GILLTWH---YDPNMTCDYV 658
           +V A NS GSS P++I  M +    L   + V         IL+TW     DP+   +YV
Sbjct: 396 AVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYV 455

Query: 659 IKW--CNSSRSEPCLMDW-RKVPSNSTETVIESDEFRPGIRYNFFLYGCR-NQGYQLLRS 714
           ++W   +        ++W R  P N +  +  S+  +  I Y   +Y    +QG     S
Sbjct: 456 VEWRELHPGGDTQVPLNWLRSRPYNVSALI--SENIKSYICYEIRVYALSGDQGG--CSS 511

Query: 715 MIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMR 774
           ++G  +  AP+  P+         SIL+ W  IPV+E  G L  Y  Y+   ERD++   
Sbjct: 512 ILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYW--KERDSNSQP 569

Query: 775 VLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGV---GPEKSMYVVTKE 831
            L     +I  +    +SQ +  I  LQ + +Y L + A T  G    G E+   +  K 
Sbjct: 570 QL----CEIPYR----VSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKA 621

Query: 832 NSVGLIIAILIPVAVAVIVGVVTS---------ILCYRKREWIKETFYPDIPNPEN 878
           N +   +A  I +A+ ++VG+ ++         +L   + +W       +IP+P N
Sbjct: 622 NWMA-FVAPSICIAI-IMVGIFSTHYFQQKVFVLLAALRPQWCSR----EIPDPAN 671


>gi|27437045 colony stimulating factor 3 receptor isoform d
           precursor [Homo sapiens]
          Length = 783

 Score =  102 bits (253), Expect = 3e-21
 Identities = 133/582 (22%), Positives = 221/582 (37%), Gaps = 69/582 (11%)

Query: 329 AGYPPDTPQQLNCETH-DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEA 387
           AGYPP  P  L+C  +     +IC W PG  T L     TS+TL +SF  +     + ++
Sbjct: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHL----PTSFTL-KSFKSRGNCQTQGDS 173

Query: 388 PTN-------------ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH 434
             +               + LL+Q   N  I+   + A N LG S S  L      V   
Sbjct: 174 ILDCVPKDGQSHCCIPRKHLLLYQ---NMGIW---VQAENALGTSMSPQLCLDPMDVVKL 227

Query: 435 TPTSFKVKDINSTA-------VKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV 487
            P   +  D +  A       ++L W        IN  CE+  K          V    +
Sbjct: 228 EPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287

Query: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW-REW 545
           E   Y   L  L P T YT +IRC        WS WS   +  TTE +P+   DTW R+ 
Sbjct: 288 EALQY--ELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQR 345

Query: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD-PQHKAEIRLDKNDYI 604
             D + + ++WKP+P+ E +G+I  Y VS     +  ++  + +  +      L      
Sbjct: 346 QLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQE 405

Query: 605 ISVVAKNSVGSSPPSKIASMEIPNDDL-KIEQVVGMGKGILLTWHYDPNMTCDYVIKW-- 661
           +++VA NS G+S P+ +   E     L ++  +      + + W         YVI+W  
Sbjct: 406 VALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL 465

Query: 662 -----CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
                 NS+++      WR   +      +  +  RP   Y   +           + + 
Sbjct: 466 GPPSASNSNKT------WRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519

Query: 717 GYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVL 776
            Y +E+AP  AP   ++        ++W   P E  +  L  Y  ++   +  +      
Sbjct: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS------ 573

Query: 777 ESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGV--GPEKSMYVVTKENSV 834
                      I + S +   +  L+  + YH+ L A +  G       ++  +T E S 
Sbjct: 574 --------FSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSE 625

Query: 835 GLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNP 876
             II  L  + + +     T+ LC       K   +P +P+P
Sbjct: 626 LHIILGLFGLLLLLTCLCGTAWLCCSPNR--KNPLWPSVPDP 665


>gi|24496783 colony stimulating factor 3 receptor isoform c
           precursor [Homo sapiens]
          Length = 863

 Score =  102 bits (253), Expect = 3e-21
 Identities = 133/582 (22%), Positives = 221/582 (37%), Gaps = 69/582 (11%)

Query: 329 AGYPPDTPQQLNCETH-DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEA 387
           AGYPP  P  L+C  +     +IC W PG  T L     TS+TL +SF  +     + ++
Sbjct: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHL----PTSFTL-KSFKSRGNCQTQGDS 173

Query: 388 PTN-------------ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH 434
             +               + LL+Q   N  I+   + A N LG S S  L      V   
Sbjct: 174 ILDCVPKDGQSHCCIPRKHLLLYQ---NMGIW---VQAENALGTSMSPQLCLDPMDVVKL 227

Query: 435 TPTSFKVKDINSTA-------VKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV 487
            P   +  D +  A       ++L W        IN  CE+  K          V    +
Sbjct: 228 EPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287

Query: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW-REW 545
           E   Y   L  L P T YT +IRC        WS WS   +  TTE +P+   DTW R+ 
Sbjct: 288 EALQY--ELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQR 345

Query: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD-PQHKAEIRLDKNDYI 604
             D + + ++WKP+P+ E +G+I  Y VS     +  ++  + +  +      L      
Sbjct: 346 QLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQE 405

Query: 605 ISVVAKNSVGSSPPSKIASMEIPNDDL-KIEQVVGMGKGILLTWHYDPNMTCDYVIKW-- 661
           +++VA NS G+S P+ +   E     L ++  +      + + W         YVI+W  
Sbjct: 406 VALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL 465

Query: 662 -----CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
                 NS+++      WR   +      +  +  RP   Y   +           + + 
Sbjct: 466 GPPSASNSNKT------WRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519

Query: 717 GYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVL 776
            Y +E+AP  AP   ++        ++W   P E  +  L  Y  ++   +  +      
Sbjct: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS------ 573

Query: 777 ESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGV--GPEKSMYVVTKENSV 834
                      I + S +   +  L+  + YH+ L A +  G       ++  +T E S 
Sbjct: 574 --------FSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSE 625

Query: 835 GLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNP 876
             II  L  + + +     T+ LC       K   +P +P+P
Sbjct: 626 LHIILGLFGLLLLLTCLCGTAWLCCSPNR--KNPLWPSVPDP 665


>gi|4503081 colony stimulating factor 3 receptor isoform a precursor
           [Homo sapiens]
          Length = 836

 Score =  102 bits (253), Expect = 3e-21
 Identities = 133/582 (22%), Positives = 221/582 (37%), Gaps = 69/582 (11%)

Query: 329 AGYPPDTPQQLNCETH-DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEA 387
           AGYPP  P  L+C  +     +IC W PG  T L     TS+TL +SF  +     + ++
Sbjct: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHL----PTSFTL-KSFKSRGNCQTQGDS 173

Query: 388 PTN-------------ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH 434
             +               + LL+Q   N  I+   + A N LG S S  L      V   
Sbjct: 174 ILDCVPKDGQSHCCIPRKHLLLYQ---NMGIW---VQAENALGTSMSPQLCLDPMDVVKL 227

Query: 435 TPTSFKVKDINSTA-------VKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV 487
            P   +  D +  A       ++L W        IN  CE+  K          V    +
Sbjct: 228 EPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287

Query: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW-REW 545
           E   Y   L  L P T YT +IRC        WS WS   +  TTE +P+   DTW R+ 
Sbjct: 288 EALQY--ELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQR 345

Query: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD-PQHKAEIRLDKNDYI 604
             D + + ++WKP+P+ E +G+I  Y VS     +  ++  + +  +      L      
Sbjct: 346 QLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQE 405

Query: 605 ISVVAKNSVGSSPPSKIASMEIPNDDL-KIEQVVGMGKGILLTWHYDPNMTCDYVIKW-- 661
           +++VA NS G+S P+ +   E     L ++  +      + + W         YVI+W  
Sbjct: 406 VALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL 465

Query: 662 -----CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
                 NS+++      WR   +      +  +  RP   Y   +           + + 
Sbjct: 466 GPPSASNSNKT------WRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519

Query: 717 GYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVL 776
            Y +E+AP  AP   ++        ++W   P E  +  L  Y  ++   +  +      
Sbjct: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS------ 573

Query: 777 ESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGV--GPEKSMYVVTKENSV 834
                      I + S +   +  L+  + YH+ L A +  G       ++  +T E S 
Sbjct: 574 --------FSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSE 625

Query: 835 GLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNP 876
             II  L  + + +     T+ LC       K   +P +P+P
Sbjct: 626 LHIILGLFGLLLLLTCLCGTAWLCCSPNR--KNPLWPSVPDP 665


>gi|27437042 colony stimulating factor 3 receptor isoform b
           precursor [Homo sapiens]
          Length = 769

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 120/522 (22%), Positives = 198/522 (37%), Gaps = 65/522 (12%)

Query: 329 AGYPPDTPQQLNCETH-DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEA 387
           AGYPP  P  L+C  +     +IC W PG  T L     TS+TL +SF  +     + ++
Sbjct: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHL----PTSFTL-KSFKSRGNCQTQGDS 173

Query: 388 PTN-------------ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH 434
             +               + LL+Q   N  I+   + A N LG S S  L      V   
Sbjct: 174 ILDCVPKDGQSHCCIPRKHLLLYQ---NMGIW---VQAENALGTSMSPQLCLDPMDVVKL 227

Query: 435 TPTSFKVKDINSTA-------VKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV 487
            P   +  D +  A       ++L W        IN  CE+  K          V    +
Sbjct: 228 EPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287

Query: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW-REW 545
           E   Y   L  L P T YT +IRC        WS WS   +  TTE +P+   DTW R+ 
Sbjct: 288 EALQY--ELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQR 345

Query: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD-PQHKAEIRLDKNDYI 604
             D + + ++WKP+P+ E +G+I  Y VS     +  ++  + +  +      L      
Sbjct: 346 QLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQE 405

Query: 605 ISVVAKNSVGSSPPSKIASMEIPNDDL-KIEQVVGMGKGILLTWHYDPNMTCDYVIKW-- 661
           +++VA NS G+S P+ +   E     L ++  +      + + W         YVI+W  
Sbjct: 406 VALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL 465

Query: 662 -----CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
                 NS+++      WR   +      +  +  RP   Y   +           + + 
Sbjct: 466 GPPSASNSNKT------WRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519

Query: 717 GYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVL 776
            Y +E+AP  AP   ++        ++W   P E  +  L  Y  ++   +  +      
Sbjct: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS------ 573

Query: 777 ESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGG 818
                      I + S +   +  L+  + YH+ L A +  G
Sbjct: 574 --------FSAILNASSRGFVLHGLEPASLYHIHLMAASQAG 607


>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
           [Homo sapiens]
          Length = 329

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 81/304 (26%), Positives = 132/304 (43%), Gaps = 36/304 (11%)

Query: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313
           + P+  V+ + S+ T  CV +EK +     H N   I     +  I     ++   + ++
Sbjct: 31  ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88

Query: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355
           V FT                   E N++G  I +G PP+ P+ L+C  ++ K++ C W+ 
Sbjct: 89  VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148

Query: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413
           GR T L     T++TL   + + K+   K + + PT+ +         N E++   + A 
Sbjct: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201

Query: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470
           N LG+  S  I  +   KV P+ P +  V   +  S+ +KL+W  P   + I     I+ 
Sbjct: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261

Query: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528
           + K  S   Q          SS+ V    L P+T Y FRIRC  E     WS WS +   
Sbjct: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319

Query: 529 LTTE 532
           +T E
Sbjct: 320 ITYE 323


>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
          Length = 958

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 108/508 (21%), Positives = 210/508 (41%), Gaps = 54/508 (10%)

Query: 235 WSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCV--SQEKVLSA--LIGHTNC--- 287
           WSDWS  +  +         FP   +  VGS+++F C+   + K++ +  ++   N    
Sbjct: 319 WSDWSTPRVFT---TQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEK 375

Query: 288 -PLIHLD--GENVA-IKIRNISVSASSGT---NVVFTTEDNIFGTVIFAGYPPDTPQQLN 340
            P    D   ++V+ +   N++ +   G    + V+   ++         Y  D    ++
Sbjct: 376 IPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINIS 435

Query: 341 CETHD-LKEIICSWNPGRVTALVGP-------RATSYTLVESFSGKYVRLKRAEAPTNES 392
           CET   L ++ C W+   + +L          R++ Y             K     ++  
Sbjct: 436 CETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGF 495

Query: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVY-PHTPTSFKVK-DINSTAVK 450
           Y+ +FQ +     Y   +  ++ LG   S     + + V  P  P+S K +  IN   +K
Sbjct: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555

Query: 451 LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIR 510
           +SW  P  F + N   +I    S    + +   +   ++ S  V+L   +   +Y  ++R
Sbjct: 556 ISWEKPV-FPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKS--VSLPVPDLCAVYAVQVR 612

Query: 511 CST-ETFWKWSKWSNKKQHLTTEAS-PSKGPDTWREWSSDG----KNLIIYWKPLPINEA 564
           C   +    WS WSN    +  +   P +GP+ WR  + D     KN+ + WKPL  N++
Sbjct: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDS 672

Query: 565 ----NGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSK 620
                  +++++ SC+      + SE      K      +  + ++V+A NS+G+S  + 
Sbjct: 673 LCSVQRYVINHHTSCNG-----TWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANF 727

Query: 621 IASMEIPNDDLKIEQVVGM----GKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDW 674
             +   P   + I Q +         ++++W   P+      ++I+W N   +E   + W
Sbjct: 728 NLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN--LNEDGEIKW 785

Query: 675 RKVPSNSTETVIESDEFRPGIRYNFFLY 702
            ++ S+S +     D F P  +Y F LY
Sbjct: 786 LRI-SSSVKKYYIHDHFIPIEKYQFSLY 812



 Score = 38.1 bits (87), Expect = 0.046
 Identities = 27/89 (30%), Positives = 51/89 (57%), Gaps = 14/89 (15%)

Query: 818 GVGPEKSMYVVTKEN------SVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYP 871
           GVG  K +   T+++        GL +  ++PV ++  + ++ ++L   +R  +K+ F+ 
Sbjct: 818 GVGKPKIINSFTQDDIEKHQSDAGLYV--IVPVIISSSILLLGTLLISHQR--MKKLFWE 873

Query: 872 DIPNPENC---KALQFQKSVCEGSSALKT 897
           D+PNP+NC   + L FQK + EGS  +K+
Sbjct: 874 DVPNPKNCSWAQGLNFQK-MLEGSMFVKS 901


>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
          Length = 896

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 108/508 (21%), Positives = 210/508 (41%), Gaps = 54/508 (10%)

Query: 235 WSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCV--SQEKVLSA--LIGHTNC--- 287
           WSDWS  +  +         FP   +  VGS+++F C+   + K++ +  ++   N    
Sbjct: 319 WSDWSTPRVFT---TQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEK 375

Query: 288 -PLIHLD--GENVA-IKIRNISVSASSGT---NVVFTTEDNIFGTVIFAGYPPDTPQQLN 340
            P    D   ++V+ +   N++ +   G    + V+   ++         Y  D    ++
Sbjct: 376 IPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINIS 435

Query: 341 CETHD-LKEIICSWNPGRVTALVGP-------RATSYTLVESFSGKYVRLKRAEAPTNES 392
           CET   L ++ C W+   + +L          R++ Y             K     ++  
Sbjct: 436 CETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGF 495

Query: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVY-PHTPTSFKVK-DINSTAVK 450
           Y+ +FQ +     Y   +  ++ LG   S     + + V  P  P+S K +  IN   +K
Sbjct: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555

Query: 451 LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIR 510
           +SW  P  F + N   +I    S    + +   +   ++ S  V+L   +   +Y  ++R
Sbjct: 556 ISWEKPV-FPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKS--VSLPVPDLCAVYAVQVR 612

Query: 511 CST-ETFWKWSKWSNKKQHLTTEAS-PSKGPDTWREWSSDG----KNLIIYWKPLPINEA 564
           C   +    WS WSN    +  +   P +GP+ WR  + D     KN+ + WKPL  N++
Sbjct: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDS 672

Query: 565 ----NGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSK 620
                  +++++ SC+      + SE      K      +  + ++V+A NS+G+S  + 
Sbjct: 673 LCSVQRYVINHHTSCNG-----TWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANF 727

Query: 621 IASMEIPNDDLKIEQVVGM----GKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDW 674
             +   P   + I Q +         ++++W   P+      ++I+W N   +E   + W
Sbjct: 728 NLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN--LNEDGEIKW 785

Query: 675 RKVPSNSTETVIESDEFRPGIRYNFFLY 702
            ++ S+S +     D F P  +Y F LY
Sbjct: 786 LRI-SSSVKKYYIHDHFIPIEKYQFSLY 812



 Score = 35.4 bits (80), Expect = 0.30
 Identities = 23/78 (29%), Positives = 44/78 (56%), Gaps = 13/78 (16%)

Query: 818 GVGPEKSMYVVTKEN------SVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYP 871
           GVG  K +   T+++        GL +  ++PV ++  + ++ ++L   +R  +K+ F+ 
Sbjct: 818 GVGKPKIINSFTQDDIEKHQSDAGLYV--IVPVIISSSILLLGTLLISHQR--MKKLFWE 873

Query: 872 DIPNPENC---KALQFQK 886
           D+PNP+NC   + L FQK
Sbjct: 874 DVPNPKNCSWAQGLNFQK 891


>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
          Length = 1165

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 108/508 (21%), Positives = 210/508 (41%), Gaps = 54/508 (10%)

Query: 235 WSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCV--SQEKVLSA--LIGHTNC--- 287
           WSDWS  +  +         FP   +  VGS+++F C+   + K++ +  ++   N    
Sbjct: 319 WSDWSTPRVFT---TQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEK 375

Query: 288 -PLIHLD--GENVA-IKIRNISVSASSGT---NVVFTTEDNIFGTVIFAGYPPDTPQQLN 340
            P    D   ++V+ +   N++ +   G    + V+   ++         Y  D    ++
Sbjct: 376 IPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINIS 435

Query: 341 CETHD-LKEIICSWNPGRVTALVGP-------RATSYTLVESFSGKYVRLKRAEAPTNES 392
           CET   L ++ C W+   + +L          R++ Y             K     ++  
Sbjct: 436 CETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGF 495

Query: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVY-PHTPTSFKVK-DINSTAVK 450
           Y+ +FQ +     Y   +  ++ LG   S     + + V  P  P+S K +  IN   +K
Sbjct: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555

Query: 451 LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIR 510
           +SW  P  F + N   +I    S    + +   +   ++ S  V+L   +   +Y  ++R
Sbjct: 556 ISWEKPV-FPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKS--VSLPVPDLCAVYAVQVR 612

Query: 511 CST-ETFWKWSKWSNKKQHLTTEAS-PSKGPDTWREWSSDG----KNLIIYWKPLPINEA 564
           C   +    WS WSN    +  +   P +GP+ WR  + D     KN+ + WKPL  N++
Sbjct: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDS 672

Query: 565 ----NGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSK 620
                  +++++ SC+      + SE      K      +  + ++V+A NS+G+S  + 
Sbjct: 673 LCSVQRYVINHHTSCNG-----TWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANF 727

Query: 621 IASMEIPNDDLKIEQVVGM----GKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDW 674
             +   P   + I Q +         ++++W   P+      ++I+W N   +E   + W
Sbjct: 728 NLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN--LNEDGEIKW 785

Query: 675 RKVPSNSTETVIESDEFRPGIRYNFFLY 702
            ++ S+S +     D F P  +Y F LY
Sbjct: 786 LRI-SSSVKKYYIHDHFIPIEKYQFSLY 812



 Score = 35.4 bits (80), Expect = 0.30
 Identities = 23/78 (29%), Positives = 44/78 (56%), Gaps = 13/78 (16%)

Query: 818 GVGPEKSMYVVTKEN------SVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYP 871
           GVG  K +   T+++        GL +  ++PV ++  + ++ ++L   +R  +K+ F+ 
Sbjct: 818 GVGKPKIINSFTQDDIEKHQSDAGLYV--IVPVIISSSILLLGTLLISHQR--MKKLFWE 873

Query: 872 DIPNPENC---KALQFQK 886
           D+PNP+NC   + L FQK
Sbjct: 874 DVPNPKNCSWAQGLNFQK 891


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
           precursor [Homo sapiens]
          Length = 1912

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 93/403 (23%), Positives = 168/403 (41%), Gaps = 43/403 (10%)

Query: 403 QEIYNFTLNAHNPLGRSQ-STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAK 461
           Q+ Y+  + A   +G    S+ +  IT+   P  P +FK +  + T++ LSW  P +   
Sbjct: 485 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI 544

Query: 462 INFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSK 521
            N+  E+  K     +EQR +TI+    +SY   L  L P +LY FR+   +      S 
Sbjct: 545 ANY--ELVYKDGEHGEEQR-ITIE--PGTSY--RLQGLKPNSLYYFRLAARSPQGLGAST 597

Query: 522 WSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSS---- 577
                +  T ++ PS  P      S    ++++ W+P P+ + NG I  Y++  ++    
Sbjct: 598 AEISAR--TMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655

Query: 578 DEETQSLSEIPDPQHKAEI-RLDK-NDYIISVVAKNSVGSSPPSKIASMEIPNDDL---- 631
           D++   +  IP    K  + +L+K  +Y I+V A   VG  P S ++ +   N+D+    
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES-LSVLIRTNEDVPSGP 714

Query: 632 --KIEQVVGMGKGILLTWHYD-PN----MTCDYVIKWCNSSRSEP---------CLMDWR 675
             K+E        + ++W    PN        Y + +      EP          L D +
Sbjct: 715 PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ 774

Query: 676 KVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVA-PNFTVED 734
               ++TE  +     +P   Y+  +     +G    RS    +     +   P   +  
Sbjct: 775 WEFDDTTEHDMIISGLQPETSYSLTVTAYTTKG-DGARSKPKLVSTTGAVPGKPRLVINH 833

Query: 735 TSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLE 777
           T  ++ L++W   P  +  G L+GY   FG+  +D   +  LE
Sbjct: 834 TQMNTALIQWH--PPVDTFGPLQGYRLKFGR--KDMEPLTTLE 872



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)

Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRV---TALVGPRATSYTLVESFSGKYVRLKRAEAP 388
           P   PQ ++C +     I+ SW P  V     ++   +  YT V+    K   +    + 
Sbjct: 609 PSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSD 668

Query: 389 TNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINS 446
           T +    L + L     Y  T+ AH  +G    +  +L+   E V    P   +V+ +NS
Sbjct: 669 TTK---YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 725

Query: 447 TAVKLSWHLP 456
           T+VK+SW  P
Sbjct: 726 TSVKVSWRSP 735



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 82/447 (18%), Positives = 173/447 (38%), Gaps = 30/447 (6%)

Query: 406 YNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKIN 463
           Y F + A N +GR   +  +L   +E+     P   + + ++ST + + W  P       
Sbjct: 389 YEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEE--PNG 446

Query: 464 FLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWS 523
            +    +  +    +  N  +K     S +  +  L P   Y+ ++   T         S
Sbjct: 447 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI--GDGPLS 504

Query: 524 NKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDE--ET 581
           +  Q +T    P + P  ++       ++++ W P      +  I +Y +     E  E 
Sbjct: 505 SDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP----PRSDTIANYELVYKDGEHGEE 559

Query: 582 QSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVG-SSPPSKIASMEIPNDDLKIEQVVGM- 639
           Q ++  P   ++ +     + Y   + A++  G  +  ++I++  + +      Q +   
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619

Query: 640 ---GKGILLTWHYDP-----NMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEF 691
                 IL++W   P      +  +Y IK+      +    +   +PS++T+ ++E  E 
Sbjct: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679

Query: 692 RPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEE 751
               R     +     G + L  +I   E++         VE  ++ S+ V W      +
Sbjct: 680 WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739

Query: 752 LRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKN----ITDISQKTLRIADLQGKTSY 807
             G +RGY  ++ + E    K + +     D+ + +      D ++  + I+ LQ +TSY
Sbjct: 740 QHGQIRGYQVHYVRMENGEPKGQPM---LKDVMLADAQWEFDDTTEHDMIISGLQPETSY 796

Query: 808 HLVLRAYTDGGVGPEKSMYVVTKENSV 834
            L + AYT  G G      +V+   +V
Sbjct: 797 SLTVTAYTTKGDGARSKPKLVSTTGAV 823



 Score = 31.6 bits (70), Expect = 4.3
 Identities = 34/130 (26%), Positives = 52/130 (40%), Gaps = 5/130 (3%)

Query: 332  PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLV-ESFSGKYVRLKRAEAPTN 390
            P   PQ L+ E      +  SW P  V A      T YTL+    +   + +++   P +
Sbjct: 918  PTGFPQNLHSEGTTSTSVQLSWQPP-VLAERNGIITKYTLLYRDINIPLLPMEQLIVPAD 976

Query: 391  ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNI-TEKVYPHTPTSFKVKDINSTAV 449
             +  L    L     Y+  + AH   G    +  V   T  V      +F VK +  T+V
Sbjct: 977  TTMTLTG--LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSV 1034

Query: 450  KLSWHLPGNF 459
             LSW +P N+
Sbjct: 1035 LLSWEIPENY 1044


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
           2 precursor [Homo sapiens]
          Length = 1899

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 93/403 (23%), Positives = 168/403 (41%), Gaps = 43/403 (10%)

Query: 403 QEIYNFTLNAHNPLGRSQ-STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAK 461
           Q+ Y+  + A   +G    S+ +  IT+   P  P +FK +  + T++ LSW  P +   
Sbjct: 472 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI 531

Query: 462 INFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSK 521
            N+  E+  K     +EQR +TI+    +SY   L  L P +LY FR+   +      S 
Sbjct: 532 ANY--ELVYKDGEHGEEQR-ITIE--PGTSY--RLQGLKPNSLYYFRLAARSPQGLGAST 584

Query: 522 WSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSS---- 577
                +  T ++ PS  P      S    ++++ W+P P+ + NG I  Y++  ++    
Sbjct: 585 AEISAR--TMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 642

Query: 578 DEETQSLSEIPDPQHKAEI-RLDK-NDYIISVVAKNSVGSSPPSKIASMEIPNDDL---- 631
           D++   +  IP    K  + +L+K  +Y I+V A   VG  P S ++ +   N+D+    
Sbjct: 643 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES-LSVLIRTNEDVPSGP 701

Query: 632 --KIEQVVGMGKGILLTWHYD-PN----MTCDYVIKWCNSSRSEP---------CLMDWR 675
             K+E        + ++W    PN        Y + +      EP          L D +
Sbjct: 702 PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ 761

Query: 676 KVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVA-PNFTVED 734
               ++TE  +     +P   Y+  +     +G    RS    +     +   P   +  
Sbjct: 762 WEFDDTTEHDMIISGLQPETSYSLTVTAYTTKG-DGARSKPKLVSTTGAVPGKPRLVINH 820

Query: 735 TSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLE 777
           T  ++ L++W   P  +  G L+GY   FG+  +D   +  LE
Sbjct: 821 TQMNTALIQWH--PPVDTFGPLQGYRLKFGR--KDMEPLTTLE 859



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)

Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRV---TALVGPRATSYTLVESFSGKYVRLKRAEAP 388
           P   PQ ++C +     I+ SW P  V     ++   +  YT V+    K   +    + 
Sbjct: 596 PSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSD 655

Query: 389 TNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINS 446
           T +    L + L     Y  T+ AH  +G    +  +L+   E V    P   +V+ +NS
Sbjct: 656 TTK---YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 712

Query: 447 TAVKLSWHLP 456
           T+VK+SW  P
Sbjct: 713 TSVKVSWRSP 722



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 82/447 (18%), Positives = 173/447 (38%), Gaps = 30/447 (6%)

Query: 406 YNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKIN 463
           Y F + A N +GR   +  +L   +E+     P   + + ++ST + + W  P       
Sbjct: 376 YEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEE--PNG 433

Query: 464 FLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWS 523
            +    +  +    +  N  +K     S +  +  L P   Y+ ++   T         S
Sbjct: 434 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI--GDGPLS 491

Query: 524 NKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDE--ET 581
           +  Q +T    P + P  ++       ++++ W P      +  I +Y +     E  E 
Sbjct: 492 SDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP----PRSDTIANYELVYKDGEHGEE 546

Query: 582 QSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVG-SSPPSKIASMEIPNDDLKIEQVVGM- 639
           Q ++  P   ++ +     + Y   + A++  G  +  ++I++  + +      Q +   
Sbjct: 547 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 606

Query: 640 ---GKGILLTWHYDP-----NMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEF 691
                 IL++W   P      +  +Y IK+      +    +   +PS++T+ ++E  E 
Sbjct: 607 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 666

Query: 692 RPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEE 751
               R     +     G + L  +I   E++         VE  ++ S+ V W      +
Sbjct: 667 WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 726

Query: 752 LRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKN----ITDISQKTLRIADLQGKTSY 807
             G +RGY  ++ + E    K + +     D+ + +      D ++  + I+ LQ +TSY
Sbjct: 727 QHGQIRGYQVHYVRMENGEPKGQPM---LKDVMLADAQWEFDDTTEHDMIISGLQPETSY 783

Query: 808 HLVLRAYTDGGVGPEKSMYVVTKENSV 834
            L + AYT  G G      +V+   +V
Sbjct: 784 SLTVTAYTTKGDGARSKPKLVSTTGAV 810



 Score = 31.6 bits (70), Expect = 4.3
 Identities = 34/130 (26%), Positives = 52/130 (40%), Gaps = 5/130 (3%)

Query: 332  PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLV-ESFSGKYVRLKRAEAPTN 390
            P   PQ L+ E      +  SW P  V A      T YTL+    +   + +++   P +
Sbjct: 905  PTGFPQNLHSEGTTSTSVQLSWQPP-VLAERNGIITKYTLLYRDINIPLLPMEQLIVPAD 963

Query: 391  ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNI-TEKVYPHTPTSFKVKDINSTAV 449
             +  L    L     Y+  + AH   G    +  V   T  V      +F VK +  T+V
Sbjct: 964  TTMTLTG--LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSV 1021

Query: 450  KLSWHLPGNF 459
             LSW +P N+
Sbjct: 1022 LLSWEIPENY 1031


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
           3 precursor [Homo sapiens]
          Length = 1903

 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 89/397 (22%), Positives = 166/397 (41%), Gaps = 40/397 (10%)

Query: 403 QEIYNFTLNAHNPLGRSQ-STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAK 461
           Q+ Y+  + A   +G    S+ +  IT+   P  P +FK +  + T++ LSW  P +   
Sbjct: 485 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI 544

Query: 462 INFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSK 521
            N+  E+  K     +EQR +TI+    +SY   L  L P +LY FR+   +      S 
Sbjct: 545 ANY--ELVYKDGEHGEEQR-ITIE--PGTSY--RLQGLKPNSLYYFRLAARSPQGLGAST 597

Query: 522 WSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSS---- 577
                +  T ++ PS  P      S    ++++ W+P P+ + NG I  Y++  ++    
Sbjct: 598 AEISAR--TMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655

Query: 578 DEETQSLSEIPDPQHKAEI-RLDK-NDYIISVVAKNSVGSSPPSKIASMEIPNDDL---- 631
           D++   +  IP    K  + +L+K  +Y I+V A   VG  P S ++ +   N+D+    
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES-LSVLIRTNEDVPSGP 714

Query: 632 --KIEQVVGMGKGILLTWHYD-PN--------MTCDYVIKWCNSSRSEPCLMDWRKVPSN 680
             K+E        + ++W    PN            YV       + +P L D   + ++
Sbjct: 715 PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD--VMLAD 772

Query: 681 STETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSI 740
           + + +I   +           Y  +  G +    ++     +     P   +  T  ++ 
Sbjct: 773 AQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG--KPRLVINHTQMNTA 830

Query: 741 LVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLE 777
           L++W   P  +  G L+GY   FG+  +D   +  LE
Sbjct: 831 LIQWH--PPVDTFGPLQGYRLKFGR--KDMEPLTTLE 863



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 109/513 (21%), Positives = 187/513 (36%), Gaps = 57/513 (11%)

Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNES 392
           P  P     E      I+ SW P R   +      +Y LV    G++   +R       S
Sbjct: 516 PGQPLNFKAEPESETSILLSWTPPRSDTIA-----NYELVYK-DGEHGEEQRITIEPGTS 569

Query: 393 YQLLFQMLPNQEIYNFTLNAHNP--LGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVK 450
           Y+L  Q L    +Y F L A +P  LG S + I     +      P        +ST++ 
Sbjct: 570 YRL--QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSIL 627

Query: 451 LSWHLPGNFAKINFLCEIEIKKSN-SVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRI 509
           +SW  P    +   + E  IK +    ++ +   I G+ + +    L++L  +T Y  RI
Sbjct: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 685

Query: 510 RCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKIL 569
             +  T       S      T E  PS  P      + +  ++ + W+    N+ +G+I 
Sbjct: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745

Query: 570 SYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIIS-----------VVAKNSVGSSPP 618
            Y V     E  +   +   P  K  +  D  D IIS           V A  + G    
Sbjct: 746 GYQVHYVRMENGEPKGQ---PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGAR 802

Query: 619 SKIASME----IPNDDLKIEQVVGMGKGILLTWH-----YDPNMTCDYVIKWCNSSRSEP 669
           SK   +     +P     +     M    L+ WH     + P     Y +K+        
Sbjct: 803 SKPKLVSTTGAVPGKPRLVINHTQMNTA-LIQWHPPVDTFGPLQ--GYRLKFGRKDMEPL 859

Query: 670 CLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGY-QLLRSMIGYIEELAPIVAP 728
             +++ +   + T T I       G  Y F L      G+ + +   I   EE+      
Sbjct: 860 TTLEFSEKEDHFTATDIHK-----GASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQ 914

Query: 729 NFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNI 788
           N   E T++ S+ + W+   + E  G +  Y   +    RD +           + ++ +
Sbjct: 915 NLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY----RDINIPL--------LPMEQL 962

Query: 789 TDISQKTLRIADLQGKTSYHLVLRAYTDGGVGP 821
              +  T+ +  L+  T+Y + +RA+T  G GP
Sbjct: 963 IVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 995



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)

Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRV---TALVGPRATSYTLVESFSGKYVRLKRAEAP 388
           P   PQ ++C +     I+ SW P  V     ++   +  YT V+    K   +    + 
Sbjct: 609 PSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSD 668

Query: 389 TNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINS 446
           T +    L + L     Y  T+ AH  +G    +  +L+   E V    P   +V+ +NS
Sbjct: 669 TTK---YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 725

Query: 447 TAVKLSWHLP 456
           T+VK+SW  P
Sbjct: 726 TSVKVSWRSP 735



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 81/443 (18%), Positives = 171/443 (38%), Gaps = 31/443 (6%)

Query: 406 YNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKIN 463
           Y F + A N +GR   +  +L   +E+     P   + + ++ST + + W  P       
Sbjct: 389 YEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEE--PNG 446

Query: 464 FLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWS 523
            +    +  +    +  N  +K     S +  +  L P   Y+ ++   T         S
Sbjct: 447 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI--GDGPLS 504

Query: 524 NKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDE--ET 581
           +  Q +T    P + P  ++       ++++ W P      +  I +Y +     E  E 
Sbjct: 505 SDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP----PRSDTIANYELVYKDGEHGEE 559

Query: 582 QSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVG-SSPPSKIASMEIPNDDLKIEQVVGM- 639
           Q ++  P   ++ +     + Y   + A++  G  +  ++I++  + +      Q +   
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619

Query: 640 ---GKGILLTWHYDP-----NMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEF 691
                 IL++W   P      +  +Y IK+      +    +   +PS++T+ ++E  E 
Sbjct: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679

Query: 692 RPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEE 751
               R     +     G + L  +I   E++         VE  ++ S+ V W      +
Sbjct: 680 WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739

Query: 752 LRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVL 811
             G +RGY  ++ + E    K + +        +K++     + + I+ LQ +TSY L +
Sbjct: 740 QHGQIRGYQVHYVRMENGEPKGQPM--------LKDVMLADAQDMIISGLQPETSYSLTV 791

Query: 812 RAYTDGGVGPEKSMYVVTKENSV 834
            AYT  G G      +V+   +V
Sbjct: 792 TAYTTKGDGARSKPKLVSTTGAV 814



 Score = 31.6 bits (70), Expect = 4.3
 Identities = 34/130 (26%), Positives = 52/130 (40%), Gaps = 5/130 (3%)

Query: 332  PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLV-ESFSGKYVRLKRAEAPTN 390
            P   PQ L+ E      +  SW P  V A      T YTL+    +   + +++   P +
Sbjct: 909  PTGFPQNLHSEGTTSTSVQLSWQPP-VLAERNGIITKYTLLYRDINIPLLPMEQLIVPAD 967

Query: 391  ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNI-TEKVYPHTPTSFKVKDINSTAV 449
             +  L    L     Y+  + AH   G    +  V   T  V      +F VK +  T+V
Sbjct: 968  TTMTLTG--LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSV 1025

Query: 450  KLSWHLPGNF 459
             LSW +P N+
Sbjct: 1026 LLSWEIPENY 1035


>gi|81158224 neuronal cell adhesion molecule isoform B precursor
           [Homo sapiens]
          Length = 1183

 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 69/281 (24%), Positives = 118/281 (41%), Gaps = 24/281 (8%)

Query: 386 EAPTNESY-----QLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFK 440
           E P++E +      L+   + + +   +T  A+  L    ++ ++++ +   P+ P   +
Sbjct: 581 ELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVD--VPNPPFDLE 638

Query: 441 VKDINSTAVKLSWHLPG---NFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALD 497
           + D    +V+LSW  PG   N     F+ E E              + G + ++ L    
Sbjct: 639 LTDQLDKSVQLSW-TPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQL---- 693

Query: 498 KLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWK 557
           KL+PY  Y+FR+  +  +  K       +Q+LT  + P K P       S+  NL+I WK
Sbjct: 694 KLSPYVNYSFRVM-AVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWK 752

Query: 558 PLPINEANGKILSYNVSC---SSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVG 614
           PL   E+NG  L Y VS      D+E  S+      ++          Y+I V A N +G
Sbjct: 753 PLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMG 812

Query: 615 SSPPSKIASMEIPNDDLKI----EQVVGMGKGILLTWHYDP 651
            +P   +  M    +DL +       V +    L   H+DP
Sbjct: 813 FAPEPAVV-MGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDP 852



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 59/252 (23%), Positives = 107/252 (42%), Gaps = 26/252 (10%)

Query: 585 SEIPDPQHKAEIRLDKN-DYIISVVAKNSVGSSPPSKIASMEIPN---DDLKIEQVVGMG 640
           +E+   Q  A+++L    +Y   V+A NS+G S PS+ +   +      D     V G+G
Sbjct: 682 TEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLG 741

Query: 641 K---GILLTWH----YDPNMT-CDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFR 692
                +++TW     ++ N     Y + W      +    +W  V   +    I S    
Sbjct: 742 SEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDD----EWTSVVVANVSKYIVSGT-P 796

Query: 693 PGIRYNFFLYGCRNQGYQLLRSMI-GYIEELAPIVAP-NFTVEDTSADSILVKWEDIPVE 750
             + Y   +    + G+    +++ G+  E  P+VAP N  V   ++    V W+ +P++
Sbjct: 797 TFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLK 856

Query: 751 ELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTL-RIADLQGKTSYHL 809
            +RG L+GY  Y+ K +  + +       R  I+ K +T    KT   +  L+  + Y L
Sbjct: 857 SIRGHLQGYRIYYWKTQSSSKR------NRRHIEKKILTFQGSKTHGMLPGLEPFSHYTL 910

Query: 810 VLRAYTDGGVGP 821
            +R     G GP
Sbjct: 911 NVRVVNGKGEGP 922



 Score = 31.2 bits (69), Expect = 5.6
 Identities = 38/188 (20%), Positives = 73/188 (38%), Gaps = 21/188 (11%)

Query: 554  IYWKPLPINEANGKILSYNV----SCSSDE------ETQSLSEIPDPQHKAEIRLDK-ND 602
            ++W P+P+    G +  Y +    + SS +      E + L+      H     L+  + 
Sbjct: 848  VHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSH 907

Query: 603  YIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGIL--LTWHYDP-----NMTC 655
            Y ++V   N  G  P S       P         + +    L  LT  +DP      +  
Sbjct: 908  YTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILT 967

Query: 656  DYVIKW--CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLR 713
            +Y +K+   NS+     L+D  K+P+N T   +++  F    ++ F+       G Q+  
Sbjct: 968  EYTLKYQPINSTHELGPLVDL-KIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITE 1026

Query: 714  SMIGYIEE 721
              +  ++E
Sbjct: 1027 EAVTTVDE 1034


>gi|148806908 fibronectin type III domain containing 1 [Homo
           sapiens]
          Length = 1894

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 74/321 (23%), Positives = 126/321 (39%), Gaps = 49/321 (15%)

Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRAT-SYTLVESFSGK---YVRLKRAEAP 388
           P+ P ++   + D   +  +W   R++    PR +  + L    SG+   YV L R E  
Sbjct: 158 PNKPLRVRVRSSD-DRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDER- 215

Query: 389 TNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH-----TPTSFKVKD 443
           T+E      + L ++ +Y  +L + N  GRSQ      +T++          P    V+ 
Sbjct: 216 THE-----IKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRV 270

Query: 444 INSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYL---------- 493
           ++S +V +SW  P             ++K   V   R  T++  E               
Sbjct: 271 MSSQSVLVSWVDP------------VLEKQKKVVASRQYTVRYREKGELARWDYKQIANR 318

Query: 494 -VALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNL 552
            V ++ L P T+Y F +R S     +  KWS      T E++P+  P+    W  +GK  
Sbjct: 319 RVLIENLIPDTVYEFAVRISQGE--RDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPT 376

Query: 553 II--YWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLD----KNDYIIS 606
           ++   W  LP  E  GK+  Y +S +   +      +  P       +D       Y+  
Sbjct: 377 VVAASWDALP--ETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFK 434

Query: 607 VVAKNSVGSSPPSKIASMEIP 627
           + A N  G  P SK   + +P
Sbjct: 435 IRATNRRGLGPHSKAFIVAMP 455


>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
            [Homo sapiens]
          Length = 1224

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 101/453 (22%), Positives = 170/453 (37%), Gaps = 44/453 (9%)

Query: 400  LPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPG-- 457
            L +Q IY    +AH  L  +     V + +   P  P +  + +  + +V+L+W      
Sbjct: 599  LEDQGIY--CCSAHTALDSAADITQVTVLD--VPDPPENLHLSERQNRSVRLTWEAGADH 654

Query: 458  NFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFW 517
            N     ++ E E  K    + +    ++G + +  L     L P+  Y FR+    E   
Sbjct: 655  NSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVIL----PLAPFVRYQFRVIAVNEV-G 709

Query: 518  KWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSS 577
            +         H T  A+P + P   R  +S  K +II W+PL   E NG  L Y V+   
Sbjct: 710  RSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKP 769

Query: 578  DEETQSLSEIPDPQHKAEIRLDK--NDYIISVVAKNSVGSSPPSKIASM----EIPNDDL 631
                    E     H   +        Y + V A N +GS P  +  ++    + P+   
Sbjct: 770  QGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAP 829

Query: 632  KIEQVVGMGKGIL-LTWHYDP-----NMTCDYVIKWCNS-----SRSEPCLMDWRKVPSN 680
             I  V  +   ++ +TW   P          Y I W  +      R+ P  ++  +    
Sbjct: 830  VIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQ 889

Query: 681  STETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSI 740
                ++ S +           Y  +  G +     I    E  P       V     D+ 
Sbjct: 890  RNSGMVPSLDAFSEFHLTVLAYNSKGAGPE-SEPYIFQTPEGVPEQPTFLKVIKVDKDTA 948

Query: 741  LVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIAD 800
             + W  +P ++L G L GYL  + +   DT ++  L    +DI   NIT  S+ +  +++
Sbjct: 949  TLSW-GLP-KKLNGNLTGYLLQY-QIINDTYEIGEL----NDI---NITTPSKPSWHLSN 998

Query: 801  LQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENS 833
            L   T Y   LRA T  G G       +T+E+S
Sbjct: 999  LNATTKYKFYLRACTSQGCGKP-----ITEESS 1026



 Score = 35.4 bits (80), Expect = 0.30
 Identities = 34/124 (27%), Positives = 52/124 (41%), Gaps = 6/124 (4%)

Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNE 391
           P   PQ +  +    KE+I  W P +     GP    Y +     G  V  +  E  TN 
Sbjct: 727 PDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGP-GLEYRVTWKPQGAPVEWEE-ETVTNH 784

Query: 392 SYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNI-TEKVYPHT-PTSFKVKDINSTAV 449
           + +++   +     Y+  + A N LG       V + + + YP T P    V  INST V
Sbjct: 785 TLRVMTPAV--YAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLV 842

Query: 450 KLSW 453
           K++W
Sbjct: 843 KVTW 846


>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
          Length = 422

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 71/310 (22%), Positives = 131/310 (42%), Gaps = 41/310 (13%)

Query: 254 VFPQDKVILVGSDITFCC--------VSQEKVLSALIGHTNCPLIH--LDGENVAIKIRN 303
           + PQD  +L+GS +   C         + E +   L G    P +   L+   +A+ + N
Sbjct: 43  ISPQDPTLLIGSSLLATCSVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALAN 102

Query: 304 ISVSAS-SGTNVVFTTEDN--IFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360
           ++ S   SG N+V    D   + G+ ++ G PP+ P  ++C + ++K++ C W PG    
Sbjct: 103 LNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPG---- 158

Query: 361 LVGPRATSYTLVE-SFSGKYVRLKRAEAPTNESYQL-------LFQMLPNQEIYNFTLNA 412
                A   T +  ++S KY      +  T E Y         + + L     Y   + A
Sbjct: 159 -----AHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEA 213

Query: 413 HNPLGRSQSTIL-VNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIK 471
            N LG ++S +L ++I + V    P    V  +     +LS       A  +FL + + +
Sbjct: 214 TNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQ 273

Query: 472 KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCS------TETFWKWSKWSNK 525
               V++  +  +    ++     L  L P T+Y  ++RC+      ++    WS+WS  
Sbjct: 274 IRYRVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWS-- 331

Query: 526 KQHLTTEASP 535
             H T  ++P
Sbjct: 332 --HPTAASTP 339


>gi|81158226 neuronal cell adhesion molecule isoform A precursor
           [Homo sapiens]
          Length = 1304

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 62/229 (27%), Positives = 95/229 (41%), Gaps = 17/229 (7%)

Query: 433 PHTPTSFKVKDINSTAVKLSWHLPG---NFAKINFLCEIEIKKSNSVQEQRNVTIKGVEN 489
           P+ P   ++ D    +V+LSW  PG   N     F+ E E              + G + 
Sbjct: 647 PNPPFDLELTDQLDKSVQLSW-TPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 705

Query: 490 SSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDG 549
           ++ L    KL+PY  Y+FR+  +  +  K       +Q+LT  + P K P       S+ 
Sbjct: 706 TAQL----KLSPYVNYSFRVM-AVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEP 760

Query: 550 KNLIIYWKPLPINEANGKILSYNVSC---SSDEETQSLSEIPDPQHKAEIRLDKNDYIIS 606
            NL+I WKPL   E+NG  L Y VS      D+E  S+      ++          Y+I 
Sbjct: 761 DNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIK 820

Query: 607 VVAKNSVGSSPPSKIASMEIPNDDLKI----EQVVGMGKGILLTWHYDP 651
           V A N +G +P   +  M    +DL +       V +    L   H+DP
Sbjct: 821 VQALNDMGFAPEPAVV-MGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDP 868



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 59/252 (23%), Positives = 107/252 (42%), Gaps = 26/252 (10%)

Query: 585 SEIPDPQHKAEIRLDKN-DYIISVVAKNSVGSSPPSKIASMEIPN---DDLKIEQVVGMG 640
           +E+   Q  A+++L    +Y   V+A NS+G S PS+ +   +      D     V G+G
Sbjct: 698 TEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLG 757

Query: 641 K---GILLTWH----YDPNMT-CDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFR 692
                +++TW     ++ N     Y + W      +    +W  V   +    I S    
Sbjct: 758 SEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDD----EWTSVVVANVSKYIVSGT-P 812

Query: 693 PGIRYNFFLYGCRNQGYQLLRSMI-GYIEELAPIVAP-NFTVEDTSADSILVKWEDIPVE 750
             + Y   +    + G+    +++ G+  E  P+VAP N  V   ++    V W+ +P++
Sbjct: 813 TFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLK 872

Query: 751 ELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTL-RIADLQGKTSYHL 809
            +RG L+GY  Y+ K +  + +       R  I+ K +T    KT   +  L+  + Y L
Sbjct: 873 SIRGHLQGYRIYYWKTQSSSKR------NRRHIEKKILTFQGSKTHGMLPGLEPFSHYTL 926

Query: 810 VLRAYTDGGVGP 821
            +R     G GP
Sbjct: 927 NVRVVNGKGEGP 938



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 61/330 (18%), Positives = 129/330 (39%), Gaps = 39/330 (11%)

Query: 554  IYWKPLPINEANGKILSYNV----SCSSDE------ETQSLSEIPDPQHKAEIRLDK-ND 602
            ++W P+P+    G +  Y +    + SS +      E + L+      H     L+  + 
Sbjct: 864  VHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSH 923

Query: 603  YIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGIL--LTWHYDP-----NMTC 655
            Y ++V   N  G  P S       P         + +    L  LT  +DP      +  
Sbjct: 924  YTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILT 983

Query: 656  DYVIKW--CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLR 713
            +Y +K+   NS+     L+D  K+P+N T   +++  F    ++ F+       G Q+  
Sbjct: 984  EYTLKYQPINSTHELGPLVDL-KIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITE 1042

Query: 714  SMIGYIEE---LAP------IVAPNFTVEDTSADS----ILVKWEDIPVEELRGFLRGYL 760
              +  ++E   L P      + A N  + + +A +      + WE    E     +  Y+
Sbjct: 1043 EAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEH----VNFYV 1098

Query: 761  FYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVG 820
             Y   G ++  +  ++   RS   +K +   +   +R+  + G + +      +  G   
Sbjct: 1099 EYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAV-GDSGFVSSEDVFETGPAM 1157

Query: 821  PEKSMYVVTKENSVGLIIAILIPVAVAVIV 850
              + + + T+   +GL+ A+ + + + +IV
Sbjct: 1158 ASRQVDIATQGWFIGLMCAVALLILILLIV 1187


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
           1 precursor [Homo sapiens]
          Length = 1907

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 95/446 (21%), Positives = 164/446 (36%), Gaps = 51/446 (11%)

Query: 407 NFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLC 466
           N+T  A + LG  ++T    +T K  P  P    V +  +T+V L+W   GN   + +  
Sbjct: 295 NYTCVAISSLGMIEAT--AQVTVKALPKPPIDLVVTETTATSVTLTWD-SGNSEPVTYY- 350

Query: 467 EIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKK 526
              I+   +  E     + GV  + Y  ++  L+P++ Y FR+  +  +  +    S   
Sbjct: 351 --GIQYRAAGTEGPFQEVDGVATTRY--SIGGLSPFSEYAFRV-LAVNSIGRGPP-SEAV 404

Query: 527 QHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSE 586
           +  T E +PS  P   +        +++ W+P    E NG +  Y V  + D        
Sbjct: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPP--EEPNGLVRGYRVYYTPDSRRP---- 458

Query: 587 IPDPQHKAEIR----------LDKNDYIISVVAKNSVGSSPPSKIASME----IPNDDLK 632
            P+  HK              L    Y + V+A  +VG  PPS    ++    +P     
Sbjct: 459 -PNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPAD 517

Query: 633 IEQVVGMGKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDE 690
            +  V     I L+W   P   +    ++ W      +       KV  + T +    D 
Sbjct: 518 FQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQ-----HKVTFDPTSSYTLED- 571

Query: 691 FRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADS--ILVKWEDIP 748
            +P   Y F L    + G  +    I      +   AP   V   S  S  + V W   P
Sbjct: 572 LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPP 631

Query: 749 VEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYH 808
            +   G +  Y   +   + +     V++    +            +  +  L+  T Y 
Sbjct: 632 ADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE----------HSSWDLVGLEKWTEYR 681

Query: 809 LVLRAYTDGGVGPEKSMYVVTKENSV 834
           + +RA+TD G GPE S  +V  +  V
Sbjct: 682 VWVRAHTDVGPGPESSPVLVRTDEDV 707



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 111/515 (21%), Positives = 186/515 (36%), Gaps = 60/515 (11%)

Query: 332  PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNE 391
            P   PQ++ C +     +  SW P    +  G         E+  G+       +  + E
Sbjct: 606  PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665

Query: 392  SYQLLFQMLPNQEIYNFTLNAHNPLGRS--QSTILVNITEKVYPHTPTSFKVKDINSTAV 449
                    L     Y   + AH  +G     S +LV   E V    P   +V+ +NSTAV
Sbjct: 666  HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAV 725

Query: 450  KLSWHLP---GNFAKINFLCEIEIKKSNSVQEQRNVTI-----------KGVENSSYLVA 495
             + W LP       +I       ++  N   E R + I           +  E+  Y   
Sbjct: 726  HVYWKLPVPSKQHGQIRGYQVTYVRLENG--EPRGLPIIQDVMLAEAQWRPEESEDYETT 783

Query: 496  LDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIY 555
            +  L P T Y+  +   T         +  K  + T      G  T    ++     ++ 
Sbjct: 784  ISGLTPETTYSVTVAAYTTK----GDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQ 839

Query: 556  WKPLPINEANGKILSYNVS-CSSDEETQSLSEI-PDPQHKAEIRLDKND-YIISVVAKN- 611
            W P    E  G++L Y +  C +DE   +  +   D QH     L K   YI  + AKN 
Sbjct: 840  WHPP--KELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNR 897

Query: 612  -SVGSSPPSKIASME-IPNDDLKIEQVVGMGKGIL-LTWHYDPNMTCDYVIKWCNSSRSE 668
              +G     +I + E +P+   +   V G+      L W  DP +  +   +  + +   
Sbjct: 898  AGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW--DPPVLAERNGRIISYTVVF 955

Query: 669  PCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGY-QLLRSMIGYIEELAPIVA 727
              +   +++ + +T+T       +P   Y+  +    ++G   L  S+      +  + A
Sbjct: 956  RDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA 1015

Query: 728  PNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKG-ERDTSKMRVLESGRSDIKVK 786
             NF V      S+L+ WE +P +  +  +   + Y G+  E D   MR L          
Sbjct: 1016 KNFRVAAAMKTSVLLSWE-VP-DSYKSAVPFKILYNGQSVEVDGHSMRKL---------- 1063

Query: 787  NITDISQKTLRIADLQGKTSYHLVL--RAYTDGGV 819
                       IADLQ  T Y  VL  R  + GG+
Sbjct: 1064 -----------IADLQPNTEYSFVLMNRGSSAGGL 1087



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 115/500 (23%), Positives = 194/500 (38%), Gaps = 63/500 (12%)

Query: 388  PTNESYQLLFQMLPNQEIYNFTLNAHNPLGRS--QSTILVNITEKVYPHTPTSFKVKDIN 445
            PT+ SY L  + L    +Y F L A + +G      TI     +      P       + 
Sbjct: 563  PTS-SYTL--EDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG 619

Query: 446  STAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNV-TIKGV--ENSSY-LVALDKLNP 501
            ST V++SW  P   ++   + +  +       E R    + G+  E+SS+ LV L+K   
Sbjct: 620  STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTE 679

Query: 502  YTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWK-PLP 560
            Y ++   +R  T+        S+     T E  PS  P        +   + +YWK P+P
Sbjct: 680  YRVW---VRAHTDV--GPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVP 734

Query: 561  INEANGKILSYNVSCSSDE--ETQSLSEIPDPQ-HKAEIRLDKND--------------Y 603
             ++ +G+I  Y V+    E  E + L  I D    +A+ R ++++              Y
Sbjct: 735  -SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTY 793

Query: 604  IISVVAKNSVGSSPPSK----IASMEIPNDDLKIEQVVGMGKGILLTWHYD---PNMTCD 656
             ++V A  + G    SK      +  +P     +     M    LL WH     P     
Sbjct: 794  SVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTA-LLQWHPPKELPGELLG 852

Query: 657  YVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGY-QLLRSM 715
            Y +++C +  + P  +D+ K   + T T +       G  Y F L      G  +     
Sbjct: 853  YRLQYCRADEARPNTIDFGKDDQHFTVTGLHK-----GTTYIFRLAAKNRAGLGEEFEKE 907

Query: 716  IGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRV 775
            I   E+L      N  V   +  +  + W+   + E  G +  Y   F    RD +  + 
Sbjct: 908  IRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVF----RDINSQQE 963

Query: 776  LESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVG 835
            L+         NIT  ++ TL    L+  T+Y + +RA+T  G GP  S  + ++   V 
Sbjct: 964  LQ---------NITTDTRFTL--TGLKPDTTYDIKVRAWTSKGSGP-LSPSIQSRTMPVE 1011

Query: 836  LIIAILIPVAVAVIVGVVTS 855
             + A    VA A+   V+ S
Sbjct: 1012 QVFAKNFRVAAAMKTSVLLS 1031


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
           2 precursor [Homo sapiens]
          Length = 1898

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 95/446 (21%), Positives = 164/446 (36%), Gaps = 51/446 (11%)

Query: 407 NFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLC 466
           N+T  A + LG  ++T    +T K  P  P    V +  +T+V L+W   GN   + +  
Sbjct: 295 NYTCVAISSLGMIEAT--AQVTVKALPKPPIDLVVTETTATSVTLTWD-SGNSEPVTYY- 350

Query: 467 EIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKK 526
              I+   +  E     + GV  + Y  ++  L+P++ Y FR+  +  +  +    S   
Sbjct: 351 --GIQYRAAGTEGPFQEVDGVATTRY--SIGGLSPFSEYAFRV-LAVNSIGRGPP-SEAV 404

Query: 527 QHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSE 586
           +  T E +PS  P   +        +++ W+P    E NG +  Y V  + D        
Sbjct: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPP--EEPNGLVRGYRVYYTPDSRRP---- 458

Query: 587 IPDPQHKAEIR----------LDKNDYIISVVAKNSVGSSPPSKIASME----IPNDDLK 632
            P+  HK              L    Y + V+A  +VG  PPS    ++    +P     
Sbjct: 459 -PNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPAD 517

Query: 633 IEQVVGMGKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDE 690
            +  V     I L+W   P   +    ++ W      +       KV  + T +    D 
Sbjct: 518 FQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQ-----HKVTFDPTSSYTLED- 571

Query: 691 FRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADS--ILVKWEDIP 748
            +P   Y F L    + G  +    I      +   AP   V   S  S  + V W   P
Sbjct: 572 LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPP 631

Query: 749 VEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYH 808
            +   G +  Y   +   + +     V++    +            +  +  L+  T Y 
Sbjct: 632 ADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE----------HSSWDLVGLEKWTEYR 681

Query: 809 LVLRAYTDGGVGPEKSMYVVTKENSV 834
           + +RA+TD G GPE S  +V  +  V
Sbjct: 682 VWVRAHTDVGPGPESSPVLVRTDEDV 707



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 115/492 (23%), Positives = 190/492 (38%), Gaps = 56/492 (11%)

Query: 388  PTNESYQLLFQMLPNQEIYNFTLNAHNPLGRS--QSTILVNITEKVYPHTPTSFKVKDIN 445
            PT+ SY L  + L    +Y F L A + +G      TI     +      P       + 
Sbjct: 563  PTS-SYTL--EDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG 619

Query: 446  STAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNV-TIKGV--ENSSY-LVALDKLNP 501
            ST V++SW  P   ++   + +  +       E R    + G+  E+SS+ LV L+K   
Sbjct: 620  STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTE 679

Query: 502  YTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWK-PLP 560
            Y ++   +R  T+        S+     T E  PS  P        +   + +YWK P+P
Sbjct: 680  YRVW---VRAHTDV--GPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVP 734

Query: 561  INEANGKILSYNVSCSSDE--ETQSLSEIPDPQHKAEIR-------LDKNDYIISVVAKN 611
             ++ +G+I  Y V+    E  E + L  I D    AE +         +  Y ++V A  
Sbjct: 735  -SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVM-LAEAQETTISGLTPETTYSVTVAAYT 792

Query: 612  SVGSSPPSK----IASMEIPNDDLKIEQVVGMGKGILLTWHYD---PNMTCDYVIKWCNS 664
            + G    SK      +  +P     +     M    LL WH     P     Y +++C +
Sbjct: 793  TKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTA-LLQWHPPKELPGELLGYRLQYCRA 851

Query: 665  SRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGY-QLLRSMIGYIEELA 723
              + P  +D+ K   + T T +       G  Y F L      G  +     I   E+L 
Sbjct: 852  DEARPNTIDFGKDDQHFTVTGLHK-----GTTYIFRLAAKNRAGLGEEFEKEIRTPEDLP 906

Query: 724  PIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDI 783
                 N  V   +  +  + W+   + E  G +  Y   F    RD +  + L+      
Sbjct: 907  SGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVF----RDINSQQELQ------ 956

Query: 784  KVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIP 843
               NIT  ++ TL    L+  T+Y + +RA+T  G GP  S  + ++   V  + A    
Sbjct: 957  ---NITTDTRFTL--TGLKPDTTYDIKVRAWTSKGSGP-LSPSIQSRTMPVEQVFAKNFR 1010

Query: 844  VAVAVIVGVVTS 855
            VA A+   V+ S
Sbjct: 1011 VAAAMKTSVLLS 1022



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 106/504 (21%), Positives = 181/504 (35%), Gaps = 47/504 (9%)

Query: 332  PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNE 391
            P   PQ++ C +     +  SW P    +  G         E+  G+       +  + E
Sbjct: 606  PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665

Query: 392  SYQLLFQMLPNQEIYNFTLNAHNPLGRS--QSTILVNITEKVYPHTPTSFKVKDINSTAV 449
                    L     Y   + AH  +G     S +LV   E V    P   +V+ +NSTAV
Sbjct: 666  HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAV 725

Query: 450  KLSWHLP---GNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYT 506
             + W LP       +I       ++  N       +    +   +    +  L P T Y+
Sbjct: 726  HVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYS 785

Query: 507  FRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANG 566
              +   T         +  K  + T      G  T    ++     ++ W P    E  G
Sbjct: 786  VTVAAYTTK----GDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPP--KELPG 839

Query: 567  KILSYNVS-CSSDEETQSLSEI-PDPQHKAEIRLDKND-YIISVVAKN--SVGSSPPSKI 621
            ++L Y +  C +DE   +  +   D QH     L K   YI  + AKN   +G     +I
Sbjct: 840  ELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 899

Query: 622  ASME-IPNDDLKIEQVVGMGKGIL-LTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPS 679
             + E +P+   +   V G+      L W  DP +  +   +  + +     +   +++ +
Sbjct: 900  RTPEDLPSGFPQNLHVTGLTTSTTELAW--DPPVLAERNGRIISYTVVFRDINSQQELQN 957

Query: 680  NSTETVIESDEFRPGIRYNFFLYGCRNQGY-QLLRSMIGYIEELAPIVAPNFTVEDTSAD 738
             +T+T       +P   Y+  +    ++G   L  S+      +  + A NF V      
Sbjct: 958  ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKT 1017

Query: 739  SILVKWEDIPVEELRGFLRGYLFYFGKG-ERDTSKMRVLESGRSDIKVKNITDISQKTLR 797
            S+L+ WE +P +  +  +   + Y G+  E D   MR L                     
Sbjct: 1018 SVLLSWE-VP-DSYKSAVPFKILYNGQSVEVDGHSMRKL--------------------- 1054

Query: 798  IADLQGKTSYHLVL--RAYTDGGV 819
            IADLQ  T Y  VL  R  + GG+
Sbjct: 1055 IADLQPNTEYSFVLMNRGSSAGGL 1078


>gi|24430212 interleukin 23 receptor precursor [Homo sapiens]
          Length = 629

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 61/242 (25%), Positives = 98/242 (40%), Gaps = 38/242 (15%)

Query: 319 EDNIFGTVIFAGYPPDTPQQLNCETHDLK-EIICSWNPGRVTALVGPRATSYTLVESFSG 377
           E  I G  I +GYPPD P ++ C  ++    + C+WN G++T +     T Y        
Sbjct: 111 ETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYI----DTKYV------- 159

Query: 378 KYVRLKRAEAPTNESY------QLLFQMLPNQEIYNFTLNAHNPLGRSQSTIL-VNITEK 430
             V +K  E    + Y       +    L   + Y   + A N LG  +S  L +++ + 
Sbjct: 160 --VHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDI 217

Query: 431 VYPHTPTSFKVKDINSTAVK--LSWHLPGNFAKINFLCEIEIKKSNSVQ---EQRNVTIK 485
           V P      + + IN+T  K  + W       K++  CE+  K + +     ++ +    
Sbjct: 218 VIPSAAVISRAETINATVPKTIIYWDSQTTIEKVS--CEMRYKATTNQTWNVKEFDTNFT 275

Query: 486 GVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASP---SKG--PD 540
            V+ S +      L P   Y F++RC       W  WS+   H T E  P   SK    D
Sbjct: 276 YVQQSEFY-----LEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHD 330

Query: 541 TW 542
           TW
Sbjct: 331 TW 332


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform
           5 precursor [Homo sapiens]
          Length = 1502

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 87/350 (24%), Positives = 142/350 (40%), Gaps = 31/350 (8%)

Query: 407 NFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLC 466
           N+T  A + LG  ++  +  IT K  P  P +  V +  +T++ L+W   GN   +++  
Sbjct: 296 NYTCVAMSTLGVIEA--IAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPVSYYI 352

Query: 467 EIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKK 526
            I+ K  NS  E+    I GV  + Y VA   L+PY+ Y FR+  +     +    S   
Sbjct: 353 -IQHKPKNS--EELYKEIDGVATTRYSVA--GLSPYSDYEFRV-VAVNNIGRGPP-SEPV 405

Query: 527 QHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSE 586
              T+E +PS  P   +        +++ WK     E NG+I  Y V  + D  TQ ++ 
Sbjct: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP--EEPNGQIQGYRVYYTMDP-TQHVNN 462

Query: 587 -----IPDPQHKAEIRL-DKNDYIISVVAKNSVGSSPPSK----IASMEIPNDDLKIEQV 636
                + D Q      L  +  Y + V+A  S+G  P S     I    +P   L  +  
Sbjct: 463 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAE 522

Query: 637 VGMGKGILLTWHYDPNMT-CDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGI 695
                 ILL+W    + T  +Y + + +    E    + R      T   ++    +P  
Sbjct: 523 PESETSILLSWTPPRSDTIANYELVYKDGEHGE----EQRITIEPGTSYRLQG--LKPNS 576

Query: 696 RYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWE 745
            Y F L     QG     + I     +  + A NF V+     S+L+ WE
Sbjct: 577 LYYFRLAARSPQGLGASTAEIS-ARTMQSMFAKNFHVKAVMKTSVLLSWE 625



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 36/127 (28%), Positives = 53/127 (41%), Gaps = 9/127 (7%)

Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNES 392
           P  P     E      I+ SW P R   +      +Y LV    G++   +R       S
Sbjct: 513 PGQPLNFKAEPESETSILLSWTPPRSDTIA-----NYELVYK-DGEHGEEQRITIEPGTS 566

Query: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLS 452
           Y+L  Q L    +Y F L A +P G   ST  ++    +      +F VK +  T+V LS
Sbjct: 567 YRL--QGLKPNSLYYFRLAARSPQGLGASTAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 623

Query: 453 WHLPGNF 459
           W +P N+
Sbjct: 624 WEIPENY 630



 Score = 37.4 bits (85), Expect = 0.078
 Identities = 33/108 (30%), Positives = 54/108 (50%), Gaps = 8/108 (7%)

Query: 403 QEIYNFTLNAHNPLGRSQ-STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAK 461
           Q+ Y+  + A   +G    S+ +  IT+   P  P +FK +  + T++ LSW  P +   
Sbjct: 482 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI 541

Query: 462 INFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRI 509
            N+  E+  K     +EQR +TI+    +SY   L  L P +LY FR+
Sbjct: 542 ANY--ELVYKDGEHGEEQR-ITIE--PGTSY--RLQGLKPNSLYYFRL 582


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform
           4 precursor [Homo sapiens]
          Length = 1501

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 87/350 (24%), Positives = 142/350 (40%), Gaps = 31/350 (8%)

Query: 407 NFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLC 466
           N+T  A + LG  ++  +  IT K  P  P +  V +  +T++ L+W   GN   +++  
Sbjct: 299 NYTCVAMSTLGVIEA--IAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPVSYYI 355

Query: 467 EIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKK 526
            I+ K  NS  E+    I GV  + Y VA   L+PY+ Y FR+  +     +    S   
Sbjct: 356 -IQHKPKNS--EELYKEIDGVATTRYSVA--GLSPYSDYEFRV-VAVNNIGRGPP-SEPV 408

Query: 527 QHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSE 586
              T+E +PS  P   +        +++ WK     E NG+I  Y V  + D  TQ ++ 
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP--EEPNGQIQGYRVYYTMDP-TQHVNN 465

Query: 587 -----IPDPQHKAEIRL-DKNDYIISVVAKNSVGSSPPSK----IASMEIPNDDLKIEQV 636
                + D Q      L  +  Y + V+A  S+G  P S     I    +P   L  +  
Sbjct: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAE 525

Query: 637 VGMGKGILLTWHYDPNMT-CDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGI 695
                 ILL+W    + T  +Y + + +    E    + R      T   ++    +P  
Sbjct: 526 PESETSILLSWTPPRSDTIANYELVYKDGEHGE----EQRITIEPGTSYRLQG--LKPNS 579

Query: 696 RYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWE 745
            Y F L     QG     + I     +  + A NF V+     S+L+ WE
Sbjct: 580 LYYFRLAARSPQGLGASTAEIS-ARTMQSMFAKNFHVKAVMKTSVLLSWE 628



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 36/127 (28%), Positives = 53/127 (41%), Gaps = 9/127 (7%)

Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNES 392
           P  P     E      I+ SW P R   +      +Y LV    G++   +R       S
Sbjct: 516 PGQPLNFKAEPESETSILLSWTPPRSDTIA-----NYELVYK-DGEHGEEQRITIEPGTS 569

Query: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLS 452
           Y+L  Q L    +Y F L A +P G   ST  ++    +      +F VK +  T+V LS
Sbjct: 570 YRL--QGLKPNSLYYFRLAARSPQGLGASTAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 626

Query: 453 WHLPGNF 459
           W +P N+
Sbjct: 627 WEIPENY 633



 Score = 37.4 bits (85), Expect = 0.078
 Identities = 33/108 (30%), Positives = 54/108 (50%), Gaps = 8/108 (7%)

Query: 403 QEIYNFTLNAHNPLGRSQ-STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAK 461
           Q+ Y+  + A   +G    S+ +  IT+   P  P +FK +  + T++ LSW  P +   
Sbjct: 485 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI 544

Query: 462 INFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRI 509
            N+  E+  K     +EQR +TI+    +SY   L  L P +LY FR+
Sbjct: 545 ANY--ELVYKDGEHGEEQR-ITIE--PGTSY--RLQGLKPNSLYYFRL 585


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 85/427 (19%), Positives = 157/427 (36%), Gaps = 52/427 (12%)

Query: 433 PHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV-ENSS 491
           P  P + KV +I  T  +LSW    +         I+ +   SV  Q   T+  V +  +
Sbjct: 598 PGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKT 657

Query: 492 YLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKN 551
           +   + +LNP+  Y FR+  S +         ++K   T EA P   P            
Sbjct: 658 HTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVR-TEEAVPEVPPSEVNGGGGSRSE 716

Query: 552 LIIYWKPLPINEANGKILSYNVSCSSDEET---QSLSEIPD-PQH--KAEIRLDKNDYII 605
           L+I W P+P    NG+   Y V+      T   Q++   PD P++  + E  +  + Y +
Sbjct: 717 LVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEV 776

Query: 606 SVVAKNSVGSSP-----------------PSKIASMEIPNDDLKIEQVVGMGKGILLTWH 648
            V   N+ G  P                 PS++++  + + ++++           + W 
Sbjct: 777 KVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNT-------IPWK 829

Query: 649 YDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQG 708
                   Y +++ N    E       KV  N T   +     +  + Y   +    + G
Sbjct: 830 LSNGHLLGYEVRYWNGGGKEES-SSKMKVAGNETSARLRG--LKSNLAYYTAVRAYNSAG 886

Query: 709 YQLLRSMIGYIEELAPIVAPNFTVEDTSADS-ILVKWEDIPVEELRGFLRGYLFYFGKGE 767
                + +    +  P   P   V   + D+ +L+ WE +   E    + GY  ++    
Sbjct: 887 AGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFY---- 942

Query: 768 RDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYV 827
                     S +++++V N    + KT     L  K  Y + ++A TDGG G       
Sbjct: 943 --------RTSSQNNVQVLN----TNKTSAELVLPIKEDYIIEVKATTDGGDGTSSEQIR 990

Query: 828 VTKENSV 834
           + +  S+
Sbjct: 991 IPRITSM 997



 Score = 32.0 bits (71), Expect = 3.3
 Identities = 27/109 (24%), Positives = 49/109 (44%), Gaps = 7/109 (6%)

Query: 952  PIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINS 1011
            P +E E    A+++ GG    +    + +   +A PE    ++  GG G + ++ +  + 
Sbjct: 667  PWVEYEFRVVASNKIGGGEPSL--PSEKVRTEEAVPEVPP-SEVNGGGGSRSELVITWDP 723

Query: 1012 TVEDIAAEEDLDKTAGYRPQANVNTWN---LVSPDSPRSIDSNSEIVSF 1057
              E++   E       +RP   V TW    + SPD+PR +  N  IV +
Sbjct: 724  VPEELQNGEGFGYVVAFRP-LGVTTWIQTVVTSPDTPRYVFRNESIVPY 771


>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
           sapiens]
          Length = 2299

 Score = 57.8 bits (138), Expect = 6e-08
 Identities = 103/464 (22%), Positives = 175/464 (37%), Gaps = 79/464 (17%)

Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNES 392
           P + + +N +      I+  W+P         + T YT+              E  TN +
Sbjct: 569 PSSIKIINYKNISSSSILLYWDPPEYP---NGKITHYTIYAM-----------ELDTNRA 614

Query: 393 YQL-------LFQMLPNQEIYNFTLNAHNPLGRS----QSTILVNITEKVYPHTPTSFKV 441
           +Q+       L   L     Y   + A   +G S    ++ I V  +E     +P   +V
Sbjct: 615 FQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEV 674

Query: 442 KDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNP 501
            D+ +  ++L W  P     I    E+  K  +++  +   T          + L  L P
Sbjct: 675 IDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTD--------IILRNLRP 726

Query: 502 YTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD--TWREWSSDGKNLIIYWKPL 559
           +TLY   +R  T  F   ++ S+     T+E  P   P+  T++  SS    L      L
Sbjct: 727 HTLYNISVRSYTR-FGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSF----L 781

Query: 560 PINEANGKILSYNV----SCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAK----N 611
           P +  NG I  Y +    S  ++E T + + +       ++      YII V A      
Sbjct: 782 PPSSPNGIIQKYTIYLKRSNGNEERTINTTSL---TQNIKVLKKYTQYIIEVSASTLKGE 838

Query: 612 SVGSSPPSKIASMEIPN---DDLKIEQVVGMGKGILLTWH--YDPNMTCDY--VIKWCNS 664
            V S+P S +   + P+    D  ++Q+ G+   + L+W    +PN    Y  V  W  S
Sbjct: 839 GVRSAPISILTEEDAPDSPPQDFSVKQLSGV--TVKLSWQPPLEPNGIILYYTVYVWNRS 896

Query: 665 SRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAP 724
           S              N TET +E  +    + Y+ ++      G    RS I  I    P
Sbjct: 897 SLK----------TINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNI--ISFQTP 944

Query: 725 IVAPNFTVEDT-----SADSILVKWEDIPVEELRGFLRGYLFYF 763
             AP+   +D      S+ SI++ W   P  +  G ++ Y  Y+
Sbjct: 945 EGAPSDPPKDVYYANLSSSSIILFW--TPPSKPNGIIQYYSVYY 986



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 141/660 (21%), Positives = 248/660 (37%), Gaps = 120/660 (18%)

Query: 223  YIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALI 282
            ++ NL +  +      S   N+SW+P +Q             + + F  VS   +L    
Sbjct: 1056 FVGNLTYESIS-----STAINVSWVPPAQP------------NGLVFYYVSL--ILQQTP 1096

Query: 283  GHTNCPL------IHLDG-ENVAIKIRNISVSASSGTNVVFT------TEDNIFGTVIFA 329
             H   PL      I+ D  E     I  I+ S   G +  +T      TE+++       
Sbjct: 1097 RHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDV------- 1149

Query: 330  GYPPDTPQQLNC-ETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAP 388
               P+T   +N  +      ++ SW+P      V P     +   +  G     +     
Sbjct: 1150 ---PETSPIINTFKNLSSTSVLLSWDPP-----VKPNGAIISYDLTLQGPN---ENYSFI 1198

Query: 389  TNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPT-SFKVKDINST 447
            T+++Y +L ++ P   +Y+F   A    G   S+IL   T++  P  P  +  + +  S 
Sbjct: 1199 TSDNYIILEELSPFT-LYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSD 1257

Query: 448  AVKLSWH---LPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTL 504
             V L W    LPG   K+ +  +I   +++++  +    I G +  + LV L+   P + 
Sbjct: 1258 FVWLKWSPSPLPGGIVKV-YSFKIHEHETDTIYYKN---ISGFKTEAKLVGLE---PVST 1310

Query: 505  YTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEA 564
            Y+ R+   T+     +++SN  +  T E+ P       +  ++  +++++ W P    +A
Sbjct: 1311 YSIRVSAFTKV-GNGNQFSNVVKFTTQESVPDV-VQNMQCMATSWQSVLVKWDPP--KKA 1366

Query: 565  NGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKN-DYIISVVAKNSVGSSPPSKIAS 623
            NG I  Y V+     E  S    P       I+L  N  Y+  V A  S G    S    
Sbjct: 1367 NGIITQYMVTV----ERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHV 1422

Query: 624  MEIPNDDLKIEQVVGMGK----GILLTW---------HYDPNMTCDYVIKWCNSSRSEPC 670
              +P     +   +           LTW           +  +T     + C    SE C
Sbjct: 1423 STLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEEC 1482

Query: 671  LMDWRKVP-----SNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPI 725
            + +++K+        + ETV    +FR    Y F +    N GY    + I       P 
Sbjct: 1483 V-EYQKIQYLYEAHLTEETVYGLKKFR---WYRFQVAASTNAGYGNASNWISTKTLPGPP 1538

Query: 726  VAP--NFTVEDTSADSILVKWEDIPVEELRGFLRG---YLFYFGKGERDTSKMRVLESGR 780
              P  N  V  TS  SI + W +  V      + G   YL      + D   +  ++S  
Sbjct: 1539 DGPPENVHVVATSPFSISISWSEPAV------ITGPTCYLIDVKSVDNDEFNISFIKSNE 1592

Query: 781  SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI 840
             +           KT+ I DL+  T Y +V+ A+T    G   + YV  K ++  ++  +
Sbjct: 1593 EN-----------KTIEIKDLEIFTRYSVVITAFT----GNISAAYVEGKSSAEMIVTTL 1637



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 118/544 (21%), Positives = 193/544 (35%), Gaps = 75/544 (13%)

Query: 318  TEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWN-PGRVTALVGPRATSYTLVESFS 376
            T  NI       G P D P+ +         II  W  P +   ++   +  Y    + S
Sbjct: 934  TRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYY---RNTS 990

Query: 377  GKYVRLKRAEAPTNE----SYQLLFQMLPNQEIYNFTLNAHNPLG---RSQSTILVNITE 429
            G +++       TN+    +   +   L     Y F L A   +G   +S   I V   +
Sbjct: 991  GTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQ 1050

Query: 430  KVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNV--TIKGV 487
             +      +   + I+STA+ +SW  P     + F     I +    Q  R+V   +   
Sbjct: 1051 DIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQ----QTPRHVRPPLVTY 1106

Query: 488  ENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGP--DTWREW 545
            E S Y    D L  YT Y  +I  STE  +    ++ +    T E  P   P  +T++  
Sbjct: 1107 ERSIY---FDNLEKYTDYILKITPSTEKGFS-DTYTAQLYIKTEEDVPETSPIINTFKNL 1162

Query: 546  SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQS------------LSEIPDPQHK 593
            SS   ++++ W P P+ + NG I+SY+++     E  S            LS        
Sbjct: 1163 SS--TSVLLSWDP-PV-KPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFF 1218

Query: 594  AEIRLDKN---DYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYD 650
            A  R  K      I+      SV  +PP  +  +   +D             + L W   
Sbjct: 1219 AAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSD------------FVWLKWSPS 1266

Query: 651  PNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQ 710
            P       +        E   + ++ +    TE  +   E           +     G Q
Sbjct: 1267 PLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQ 1326

Query: 711  LLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDT 770
                +    +E  P V  N     TS  S+LVKW+  P ++  G +  Y+      ER++
Sbjct: 1327 FSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWD--PPKKANGIITQYMVTV---ERNS 1381

Query: 771  SKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTK 830
            +K+   +   + IK                L   TSY   +RA T  G G E + +V T 
Sbjct: 1382 TKVSPQDHMYTFIK----------------LLANTSYVFKVRASTSAGEGDESTCHVSTL 1425

Query: 831  ENSV 834
              +V
Sbjct: 1426 PETV 1429



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 85/406 (20%), Positives = 165/406 (40%), Gaps = 44/406 (10%)

Query: 417  GRSQSTILVNITEKVYPHTPTS-FKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNS 475
            G+++S I+   T +  P  P       +++S+++ L W  P     I     +  + ++ 
Sbjct: 932  GKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSG 991

Query: 476  VQEQRNVTIKGV----ENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTT 531
               Q N T+  V    +N +    +DKL  ++ YTF +  ST +    +K S+  +  T 
Sbjct: 992  TFMQ-NFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTAST-SVGNGNKSSDIIEVYTD 1049

Query: 532  EASPS--KGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD 589
            +  P    G  T+   SS   N  + W  +P  + NG ++ Y VS    ++T      P 
Sbjct: 1050 QDIPEGFVGNLTYESISSTAIN--VSW--VPPAQPNG-LVFYYVSLIL-QQTPRHVRPPL 1103

Query: 590  PQHKAEIRLDK----NDYIISVVAKNSVGSSPPSKI-----ASMEIPNDDLKIEQVVGMG 640
              ++  I  D      DYI+ +      G S             ++P     I     + 
Sbjct: 1104 VTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLS 1163

Query: 641  K-GILLTWH--YDPN---MTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPG 694
               +LL+W     PN   ++ D  ++  N + S             +++  I  +E  P 
Sbjct: 1164 STSVLLSWDPPVKPNGAIISYDLTLQGPNENYS-----------FITSDNYIILEELSPF 1212

Query: 695  IRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAP-NFTVEDTSADSILVKWEDIPVEELR 753
              Y+FF      +G      +  Y +E  P+  P N T+ + ++D + +KW   P+    
Sbjct: 1213 TLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLP--G 1270

Query: 754  GFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIA 799
            G ++ Y F   + E DT   + +   +++ K+  +  +S  ++R++
Sbjct: 1271 GIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVS 1316



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 73/359 (20%), Positives = 134/359 (37%), Gaps = 61/359 (16%)

Query: 312  TNVV-FTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYT 370
            +NVV FTT++++          PD  Q + C     + ++  W+P +    +    T Y 
Sbjct: 1328 SNVVKFTTQESV----------PDVVQNMQCMATSWQSVLVKWDPPKKANGI---ITQYM 1374

Query: 371  L-VESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRS-QSTILVNIT 428
            + VE  S K        +P +  Y  + ++L N   Y F + A    G   +ST  V+  
Sbjct: 1375 VTVERNSTKV-------SPQDHMYTFI-KLLANTS-YVFKVRASTSAGEGDESTCHVSTL 1425

Query: 429  EKVYPHTPTSFKVKDINSTAVKLSWHLP----GNFAKINFLCEIEIKKSNSVQEQRNVTI 484
             +  P  PT+    D+ ST+  L+W  P    G F       ++  +K    + +  V  
Sbjct: 1426 PETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEY 1485

Query: 485  KGVE--NSSYLV--ALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQHLTTEASPSKGP 539
            + ++    ++L    +  L  +  Y F++  ST   +   S W + K   T    P   P
Sbjct: 1486 QKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTK---TLPGPPDGPP 1542

Query: 540  DTWREWSSDGKNLIIYW-KPLPINEANGKIL--------SYNVSCSSDEETQSLSEIPDP 590
            +     ++   ++ I W +P  I      ++         +N+S     E     EI D 
Sbjct: 1543 ENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDL 1602

Query: 591  Q---------------HKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIE 634
            +                 A     K+   + V    S    PP+ +   +IP++  K +
Sbjct: 1603 EIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQ 1661



 Score = 39.3 bits (90), Expect = 0.021
 Identities = 86/438 (19%), Positives = 159/438 (36%), Gaps = 68/438 (15%)

Query: 409 TLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSW---HLPGNFAKINFL 465
           +++A   +G    T+L   T +  P +      K+I+S+++ L W     P        +
Sbjct: 545 SVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTI 604

Query: 466 CEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNK 525
             +E+  + + Q      I  ++NS  +  L K   YT Y  R+  ST          N 
Sbjct: 605 YAMELDTNRAFQ------ITTIDNSFLITGLKK---YTKYKMRVAASTHVGESSLSEEND 655

Query: 526 KQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDE----ET 581
               T+E  P   P            + + W   P  + NG I++Y V   + +    + 
Sbjct: 656 IFVRTSEDEPESSPQDVEVIDVTADEIRLKWS--PPEKPNGIIIAYEVLYKNIDTLYMKN 713

Query: 582 QSLSEI------PDPQHKAEIRL-------DKNDYIISVVAKNSVGSSPPSKIASMEIPN 628
            S ++I      P   +   +R        ++   ++SV    +V  S P  I    I +
Sbjct: 714 TSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISS 773

Query: 629 DDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIES 688
            ++++  +       ++           Y I    S+ +E   +       N+T      
Sbjct: 774 GEIELSFLPPSSPNGIIQ---------KYTIYLKRSNGNEERTI-------NTTSLTQNI 817

Query: 689 DEFRPGIRYNFFLYGCRNQGYQLLRSMIGYI-EELAPIVAP-NFTVEDTSADSILVKWED 746
              +   +Y   +     +G  +  + I  + EE AP   P +F+V+  S  ++ + W+ 
Sbjct: 818 KVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQ- 876

Query: 747 IPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTS 806
            P  E  G +  Y  Y                 RS +K  N+T+ S   L ++DL     
Sbjct: 877 -PPLEPNGIILYYTVYVW--------------NRSSLKTINVTETS---LELSDLDYNVE 918

Query: 807 YHLVLRAYTDGGVGPEKS 824
           Y   + A T  G G  +S
Sbjct: 919 YSAYVTASTRFGDGKTRS 936



 Score = 34.3 bits (77), Expect = 0.66
 Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 7/169 (4%)

Query: 406 YNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFL 465
           Y+ T+++ +    S  T +V  T    P  P     + + S  + LSW+ P N      +
Sbjct: 30  YDITISSISTTYTSPVTRIVT-TNVTKPGPPVFLAGERVGSAGILLSWNTPPN-PNGRII 87

Query: 466 CEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNK 525
             I   K      Q   T    +  S  V L  LNP T  T+ I+ + E       +S+ 
Sbjct: 88  SYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGT--TYEIKVAAENSAGIGVFSDP 145

Query: 526 KQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVS 574
               T E++P K  +   E  +     +I++ P    + NGKI S+ +S
Sbjct: 146 FLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP---RQPNGKITSFKIS 191



 Score = 32.0 bits (71), Expect = 3.3
 Identities = 37/156 (23%), Positives = 58/156 (37%), Gaps = 9/156 (5%)

Query: 473 SNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTE 532
           S+S   Q  ++    E  S++V    L PYT Y F +  +T      + + +     T E
Sbjct: 249 SSSTLTQNEISSVWKEPISFVVT--HLRPYTTYLFEVSAATTE----AGYIDSTIVRTPE 302

Query: 533 ASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQH 592
           + P   P      +  GK+  I W P  I    GK  SY V           +   D + 
Sbjct: 303 SVPEGPPQNCVTGNITGKSFSILWDPPTI--VTGK-FSYRVELYGPSGRILDNSTKDLKF 359

Query: 593 KAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPN 628
                     Y + + A+ S G+ P S I+    P+
Sbjct: 360 AFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPD 395


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
           isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 94/462 (20%), Positives = 173/462 (37%), Gaps = 53/462 (11%)

Query: 400 LPNQEIYNFTLNAHNPLGRSQSTILVNI-TEKVYPHTPTSFKVKDINSTAVKLSWHLPGN 458
           L   E Y   + A   +G    +  + + T++  P  P + + +  + T++ LSW  P  
Sbjct: 491 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQ 550

Query: 459 FAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWK 518
            + I +  E+  ++ +     R V       +SY+V  + L P T Y FR+   +     
Sbjct: 551 ESIIKY--ELLFREGD---HGREVGRTFDPTTSYVV--EDLKPNTEYAFRLAARSPQ--G 601

Query: 519 WSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSC--- 575
              ++   +  T ++ PS  P   +  S     +++ W+P P    NG ++ Y+V     
Sbjct: 602 LGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 661

Query: 576 -SSDEETQSLSEIPDPQHKAEIR-LDK-NDYIISVVAKNSVGSSPPSKIASMEIPND--- 629
            S D E + ++ IP    +  +  L+K   Y I+ VA   VG  P S    +    D   
Sbjct: 662 GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS 721

Query: 630 --DLKIEQVVGMGKGILLTWHYDP---------NMTCDYVIKWCNSSRSEPCLMD----- 673
               K+E        I + W                  YV      +R  P + D     
Sbjct: 722 APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 781

Query: 674 --WRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFT 731
             W    +   E VI + +           Y  +  G +    ++  + + A +  P  +
Sbjct: 782 AQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVV--VTKGAVLGRPTLS 839

Query: 732 VEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDI 791
           V+ T   S+L +WE  P       + GY   FG+   D++ +  LE   S+ +       
Sbjct: 840 VQQTPEGSLLARWEP-PAGTAEDQVLGYRLQFGR--EDSTPLATLEFPPSEDR------- 889

Query: 792 SQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENS 833
                  + +    +Y   L A + GG+G E +  +   E++
Sbjct: 890 ----YTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDT 927



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 88/450 (19%), Positives = 160/450 (35%), Gaps = 48/450 (10%)

Query: 332  PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNE 391
            P   PQ + C +     I+ SW P        P  T    +  +S +Y  L   +    E
Sbjct: 618  PSAPPQDVKCVSVRSTAILVSWRP-------PPPETHNGALVGYSVRYRPLGSEDPEPKE 670

Query: 392  -------SYQLLFQMLPNQEIYNFTLNAHNPL--GRSQSTILVNITEKVYPHTPTSFKVK 442
                   + Q+L + L     Y  T  AH  +  G   S ++V   E V    P   + +
Sbjct: 671  VNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAE 730

Query: 443  DINSTAVKLSWHLPGNFAKINFL--CEIEIKKSNSVQEQRNVTIKGV----------ENS 490
             +N+TA+++ W  P    +   +   ++   +    + +    IK V          + +
Sbjct: 731  ALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTA 790

Query: 491  SYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGK 550
             Y + +  L P T Y+  +   T    K     +K + + T+ +    P    + + +G 
Sbjct: 791  EYEMVITNLQPETAYSITVAAYT---MKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEG- 846

Query: 551  NLIIYWKPLPINEANGKILSYNVSCSSDEET--QSLSEIPDPQHKAEIRLDKNDYIISVV 608
            +L+  W+P P   A  ++L Y +    ++ T   +L   P         + K    +  +
Sbjct: 847  SLLARWEP-PAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRL 905

Query: 609  AKNSVGSSPPSKIASMEIPNDDLK----IEQVVGMGKG--ILLTWHYD-PNMTCDYVIKW 661
            A  S G         + IP D  +    I +  G      +LL W    P      ++K+
Sbjct: 906  AARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKY 965

Query: 662  CNSSRSEPCLMDWRK-----VPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
              + R    L   R+           E  +     +P   Y+  +     +G       +
Sbjct: 966  TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1025

Query: 717  GYIEELAPIVAP-NFTVEDTSADSILVKWE 745
             Y   L   V+P NF V+     S+L+ WE
Sbjct: 1026 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWE 1055



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 98/512 (19%), Positives = 191/512 (37%), Gaps = 53/512 (10%)

Query: 349 IICSWNPGRVTALVGPRATSYTLVE----SFSGKYVRLKRAEAPTNESYQLLFQMLPNQE 404
           I  +W+ G       P   SY ++E    S  G Y ++K     T  S   +  + PN E
Sbjct: 348 ITITWDSGN------PDPVSYYVIEYKSKSQDGPY-QIKEDITTTRYS---IGGLSPNSE 397

Query: 405 IYNFTLNAHNPLGRS--QSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLP----GN 458
            Y   ++A N +G+     +++    E+     P + + + +++T + + W  P    G 
Sbjct: 398 -YEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGL 456

Query: 459 FAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWK 518
                    +E +      ++ NV      + S L  +  L     YT R+   T     
Sbjct: 457 IRGYRVYYTMEPEHPVGNWQKHNV------DDSLLTTVGSLLEDETYTVRVLAFTSV--G 508

Query: 519 WSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSD 578
               S+  Q  T +  P + P   R  +    ++ + W P P  E+   I+ Y +     
Sbjct: 509 DGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSP-PRQES---IIKYELLFREG 563

Query: 579 EETQSLSEIPDP--QHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEI-------PND 629
           +  + +    DP   +  E      +Y   + A++  G    + +            P  
Sbjct: 564 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQ 623

Query: 630 DLKIEQVVGMGKGILLTWHYDPNMTCD-----YVIKWCNSSRSEPCLMDWRKVPSNSTET 684
           D+K   V      IL++W   P  T +     Y +++      +P   +   +P  +T+ 
Sbjct: 624 DVKCVSV--RSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQI 681

Query: 685 VIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKW 744
           ++E+ E     R     +     G +    ++   E++          E  +A +I V W
Sbjct: 682 LLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLW 741

Query: 745 EDIPVEELRGFLRGYLFYFGK--GERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQ 802
                    G +RGY  ++ +  G       R+ +   +D + +   D ++  + I +LQ
Sbjct: 742 RSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWET-DDTAEYEMVITNLQ 800

Query: 803 GKTSYHLVLRAYTDGGVGPEKSMYVVTKENSV 834
            +T+Y + + AYT  G G      VV  + +V
Sbjct: 801 PETAYSITVAAYTMKGDGARSKPKVVVTKGAV 832



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 31/124 (25%), Positives = 44/124 (35%), Gaps = 12/124 (9%)

Query: 385  AEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH-TPTSFKVKD 443
            A A       L  Q L     Y+  + AH   G    +  V     +    +P +FKVK 
Sbjct: 985  AAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKM 1044

Query: 444  INSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYT 503
            I  T+V LSW  P N+                 + Q N     V+  +    +  L P+T
Sbjct: 1045 IMKTSVLLSWEFPDNY-----------NSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHT 1093

Query: 504  LYTF 507
             Y F
Sbjct: 1094 FYNF 1097


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,154,517
Number of Sequences: 37866
Number of extensions: 2133181
Number of successful extensions: 6132
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 5193
Number of HSP's gapped (non-prelim): 832
length of query: 1097
length of database: 18,247,518
effective HSP length: 113
effective length of query: 984
effective length of database: 13,968,660
effective search space: 13745161440
effective search space used: 13745161440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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