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Search of human proteins with 189011586
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189011586 amyotrophic lateral sclerosis 2 (juvenile)
chromosome region, candidate 12 isoform a [Homo sapiens]
(445 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189011586 amyotrophic lateral sclerosis 2 (juvenile) chromoso... 894 0.0
gi|189011592 amyotrophic lateral sclerosis 2 (juvenile) chromoso... 830 0.0
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 74 3e-13
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 71 2e-12
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 71 2e-12
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 69 1e-11
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 65 1e-10
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens] 64 3e-10
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 64 4e-10
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 64 4e-10
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 62 1e-09
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 62 1e-09
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 61 2e-09
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 61 2e-09
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 61 2e-09
gi|221219020 NYD-SP11 protein [Homo sapiens] 61 2e-09
gi|71061468 centromere protein E [Homo sapiens] 60 3e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 58 2e-08
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 58 2e-08
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 57 3e-08
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 57 3e-08
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 57 3e-08
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 57 3e-08
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 57 3e-08
gi|156104908 myosin heavy chain 6 [Homo sapiens] 57 3e-08
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 57 3e-08
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 57 4e-08
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 57 4e-08
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 56 8e-08
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 55 1e-07
>gi|189011586 amyotrophic lateral sclerosis 2 (juvenile) chromosome
region, candidate 12 isoform a [Homo sapiens]
Length = 445
Score = 894 bits (2310), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 1 MYPNPLIYCTCWDPWNLGPRKLIKTPQLPRKNSTGSSKLTPLVPAPKNHNYLQPTKPVVS 60
MYPNPLIYCTCWDPWNLGPRKLIKTPQLPRKNSTGSSKLTPLVPAPKNHNYLQPTKPVVS
Sbjct: 1 MYPNPLIYCTCWDPWNLGPRKLIKTPQLPRKNSTGSSKLTPLVPAPKNHNYLQPTKPVVS 60
Query: 61 PKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGR 120
PKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGR
Sbjct: 61 PKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGR 120
Query: 121 FSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEA 180
FSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEA
Sbjct: 121 FSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEA 180
Query: 181 HEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQK 240
HEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQK
Sbjct: 181 HEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQK 240
Query: 241 AKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQ 300
AKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQ
Sbjct: 241 AKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQ 300
Query: 301 SDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYT 360
SDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYT
Sbjct: 301 SDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYT 360
Query: 361 QLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSG 420
QLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSG
Sbjct: 361 QLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSG 420
Query: 421 RLASITVSKDDSDTVQDGSKKGQES 445
RLASITVSKDDSDTVQDGSKKGQES
Sbjct: 421 RLASITVSKDDSDTVQDGSKKGQES 445
>gi|189011592 amyotrophic lateral sclerosis 2 (juvenile) chromosome
region, candidate 12 isoform b [Homo sapiens]
Length = 422
Score = 830 bits (2145), Expect = 0.0
Identities = 422/445 (94%), Positives = 422/445 (94%), Gaps = 23/445 (5%)
Query: 1 MYPNPLIYCTCWDPWNLGPRKLIKTPQLPRKNSTGSSKLTPLVPAPKNHNYLQPTKPVVS 60
MYPNPLIYCTCWDPWNLGPRKLIKTPQLPRKNSTGSSKLTPLVPAPKNHNYLQPTKPVVS
Sbjct: 1 MYPNPLIYCTCWDPWNLGPRKLIKTPQLPRKNSTGSSKLTPLVPAPKNHNYLQPTKPVVS 60
Query: 61 PKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGR 120
PKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGR
Sbjct: 61 PKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGR 120
Query: 121 FSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEA 180
FSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEA
Sbjct: 121 FSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEA 180
Query: 181 HEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQK 240
HEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQK
Sbjct: 181 HEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQK 240
Query: 241 AKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQ 300
AKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQ
Sbjct: 241 AKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQ 300
Query: 301 SDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYT 360
SDTLQLEELRKTKE VMQEELHAQALILESLNTNLYYT
Sbjct: 301 SDTLQLEELRKTKE-----------------------VMQEELHAQALILESLNTNLYYT 337
Query: 361 QLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSG 420
QLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSG
Sbjct: 338 QLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSG 397
Query: 421 RLASITVSKDDSDTVQDGSKKGQES 445
RLASITVSKDDSDTVQDGSKKGQES
Sbjct: 398 RLASITVSKDDSDTVQDGSKKGQES 422
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 73.6 bits (179), Expect = 3e-13
Identities = 66/292 (22%), Positives = 144/292 (49%), Gaps = 16/292 (5%)
Query: 130 LEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELE 189
+E + SE+ ++++ R + A KLL + L+ E ++ K + E +EL
Sbjct: 233 VESEKSEIQLNVKELKRKLERA-KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291
Query: 190 NNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKF 249
N + + +EK++E ++ + + R ++ I ++ E+ +++ W+K+EK
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 250 ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFE-NFIQEKEELLKQHQSDTLQLEE 308
R+ ++ +K++ ++ E E+++KI E + E I+E+EE K+ + + ++ +E
Sbjct: 352 RRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEE--KRQEEEKIREQE 409
Query: 309 LRKTKEVP-WRRDQ-INRHWHDVLQQLLLMQVMQEELHAQALILE----SLNTNLYYTQL 362
R+ +E WR+++ I + +Q M +E++H Q I E ++ +
Sbjct: 410 KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 469
Query: 363 ELQKEKAIVGNLEKM-LQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEE 413
++++++ I EKM Q K + EEK EE +H +++ I + EE
Sbjct: 470 KIREQEEIWRQKEKMHEQEKIRKQEEKVWR-----QEEKMHDQEEKIREQEE 516
Score = 67.4 bits (163), Expect = 2e-11
Identities = 70/360 (19%), Positives = 167/360 (46%), Gaps = 32/360 (8%)
Query: 69 RQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIIS 128
RQEE + + E I + +R +E+ + +E R++ E +K R + ++
Sbjct: 304 RQEEKIQEWEEKIQEQE--EKIREQEE-KIREQEEKMRRQEEMMWEKEEKMR-RQEEMMW 359
Query: 129 DLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSEL 188
+ EE++ L ++ + + ++ + + +R E K+ E K RE ++ E E
Sbjct: 360 EKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 419
Query: 189 ENNYKAALKAEKLAAQEKL-----EEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKW 243
K + EK+ QEK E++ ++ K + R Q+ ++ + EEK +Q+ W
Sbjct: 420 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ-EEKIREQEEIW 478
Query: 244 KKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDT 303
++ EK + + +Q++K+ ++ E + ++++KI E E +++E++ +Q +
Sbjct: 479 RQKEKMHEQEKIRKQEEKVWRQ-EEKMHDQEEKIREQ----EEKMWRQEEKIREQEEKIR 533
Query: 304 LQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLE 363
Q E++R+ +E+ +++ + +Q+ M+ +E++ Q + + + +
Sbjct: 534 EQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEK 593
Query: 364 LQKEKAIVGNLEKMLQT-----------------KFAETEEKYKHTIQILTEENIHLKQK 406
+ +++ + E+M+Q K E EEK + + + E+ + L+Q+
Sbjct: 594 IWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 653
Score = 61.6 bits (148), Expect = 1e-09
Identities = 68/297 (22%), Positives = 130/297 (43%), Gaps = 29/297 (9%)
Query: 53 QPTKPVVSPKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWE 112
Q K K++ RQE+ K + + + + +R +E+ +++ +++K E
Sbjct: 395 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 454
Query: 113 SEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFEN 172
E + + EE+I E I Q + H+ + E R E + E
Sbjct: 455 EE-----KRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEE 509
Query: 173 KNRELKEAHEAELSELENNYKAALKAEKLAAQE-KLEEMGKEYKYLKNMFRTYQDSIYDE 231
K RE +E K + EK+ QE K+ E ++ + + M + ++ + E
Sbjct: 510 KIREQEE-------------KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKM-GE 555
Query: 232 MEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQE 291
EEK +Q+ +++EK + ++++K+ ++ E + E+++KI E E +QE
Sbjct: 556 QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQ-----EEMMQE 610
Query: 292 KEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHD---VLQQLLLMQVMQEELHA 345
+EE + + + + EE + +E RR Q + W + QQ MQ QE L A
Sbjct: 611 QEEKMWEQEEKMCEQEEKMQEQEEKMRR-QEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 59.3 bits (142), Expect = 7e-09
Identities = 101/424 (23%), Positives = 182/424 (42%), Gaps = 79/424 (18%)
Query: 20 RKLIKTPQLPRKNSTGSSKLTPLVPAPKNHNYLQPTKPVVSPKMKIHSAR--------QE 71
R I +L KN+ KL LV + K+ L V K K+ A+ Q
Sbjct: 211 RNTITDEELKEKNAKLQEKLQ-LVESEKSEIQLN----VKELKRKLERAKLLLPQQQLQA 265
Query: 72 ETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLE 131
E + E+ +VS Q ++ L + ++ R E +I + I + E
Sbjct: 266 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEW-----EEKIQEQE 320
Query: 132 EQISELTAIIEQMNRDHQSAQKLL--SSEMDLRCAEMKQNFENKNRELKEA---HEAELS 186
E+I E I + + ++++ E R EM E K R L+E E ++
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIR 380
Query: 187 ELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAK-WKK 245
ELE EK+ QEK+ E ++ R ++ I ++ EK +Q+AK W++
Sbjct: 381 ELE---------EKMHEQEKIREQEEK--------RQEEEKIREQ--EKRQEQEAKMWRQ 421
Query: 246 DEKF-ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEK--EELLKQHQSD 302
+EK E+E + +Q+KKM + +++KI+E QEK EE +Q Q +
Sbjct: 422 EEKIREQEEKIREQEKKMWR--------QEEKIHE----------QEKIREEEKRQEQEE 463
Query: 303 TLQLEELRKTKEVPWR-------RDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNT 355
+ EE + +E WR +++I + V +Q M +E++ Q +
Sbjct: 464 MWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEE 523
Query: 356 NLYYTQLELQKEKAIVGNLEKMLQ---TKFAETEEKYKHTIQILTEENIHLKQKIISKNE 412
+ + ++++++ + E+M+Q K E EEK + ++ +E +KI + E
Sbjct: 524 KIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE-----EKIREQEE 578
Query: 413 EICE 416
+I E
Sbjct: 579 KIRE 582
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 71.2 bits (173), Expect = 2e-12
Identities = 74/359 (20%), Positives = 170/359 (47%), Gaps = 29/359 (8%)
Query: 53 QPTKPVVSPKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWE 112
Q K K++ RQE+ K + + + + +R +E+ +++ +++K E
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 468
Query: 113 SEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDL-RCAEMKQNFE 171
E + + EE+I E I Q + H+ +K+ E + R E + E
Sbjct: 469 EE-----KRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQE 523
Query: 172 NKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDE 231
K RE +E + ++ + + EK+ QEK+ E K + M+R ++ I ++
Sbjct: 524 EKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ-EEKIREQ 582
Query: 232 MEEKW-SKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFEN--F 288
E+ W ++K + +++++ E+E + +Q++K+ ++ E + E+++KI E + E
Sbjct: 583 EEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ-EEKIQEQEEKIREQEEKIREQEEM 641
Query: 289 IQEKEELLKQHQSDTLQLEE-LRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQA 347
QE+EE + + + + EE +++ +E WR+++ + +Q ++ +E++ Q
Sbjct: 642 TQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEE------KIREQEKKIREQEEKIREQE 695
Query: 348 LILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQK 406
+++ ++ ++E+ + EKM E EEK + + + E+ + L+Q+
Sbjct: 696 EMMQEQEEKMW------EQEEKMCEQEEKM-----QEQEEKMRRQEEKMWEQEVRLRQQ 743
Score = 68.2 bits (165), Expect = 1e-11
Identities = 56/285 (19%), Positives = 135/285 (47%), Gaps = 8/285 (2%)
Query: 130 LEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELE 189
+E + SE+ ++++ R + A KLL + L+ E ++ K + E +EL
Sbjct: 233 VESEKSEIQLNVKELKRKLERA-KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291
Query: 190 NNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKF 249
N + + +EK++E ++ + + R ++ I ++ E+ +++ W+K+EK
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 250 ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEEL 309
R+ ++ +K++ ++ E E+++K+ E + EKEE +++ + + E++
Sbjct: 352 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ-----EEMMWEKEEKIRELEEKMHEQEKI 406
Query: 310 RKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKA 369
R+ +E ++I R +Q M +E++ Q + ++ + ++ +++
Sbjct: 407 REQEEKRQEEEKI-REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 465
Query: 370 IVGNLEKMLQTKFAETEEKYKHTIQILTE-ENIHLKQKIISKNEE 413
I ++ Q + EEK +I + E +H +++ I K EE
Sbjct: 466 IREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Score = 59.3 bits (142), Expect = 7e-09
Identities = 71/327 (21%), Positives = 145/327 (44%), Gaps = 35/327 (10%)
Query: 102 DEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDL 161
+EM K+ E+ +K I + EE+ E I EQ R Q A K+ E +
Sbjct: 383 EEMMWEKEEKIRELEEK--MHEQEKIREQEEKRQEEEKIREQEKRQEQEA-KMWRQEEKI 439
Query: 162 RCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNM- 220
R E K + K +E E ++ K + E +EK+ E + ++ + M
Sbjct: 440 REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMH 499
Query: 221 -----FRTYQDSIYD------EMEEKWSKQKAK-WKKDEKFERENILLQQKKKMTKKFEM 268
R ++ ++ E EEK +Q+ K W+++EK + + ++++KM ++ ++
Sbjct: 500 EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKI 559
Query: 269 ESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHD 328
E+ ++ + E +++E++ +Q + Q E+ ++ +E W++++ R +
Sbjct: 560 WEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEE 619
Query: 329 VLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEK 388
+Q+ +E++ Q E + TQ + +K +G E+ K E EEK
Sbjct: 620 KIQE------QEEKIREQE---EKIREQEEMTQEQEEK----MGEQEE----KMCEQEEK 662
Query: 389 YKHTIQIL--TEENIHLKQKIISKNEE 413
+ + + EE I ++K I + EE
Sbjct: 663 MQEQEETMWRQEEKIREQEKKIREQEE 689
Score = 58.5 bits (140), Expect = 1e-08
Identities = 90/366 (24%), Positives = 158/366 (43%), Gaps = 61/366 (16%)
Query: 100 LGDEMFDRKKRWESEIPDKGRFSRTNIISD-----LEEQISELTAII-EQMNRDHQSAQK 153
LG E+ + ++++ + ++R N + EE+I E I EQ + + +K
Sbjct: 270 LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK 329
Query: 154 LLSSEMDLRCAE--MKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEK----- 206
+ E +R E M + E R+ + E E K EK+ QE+
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 389
Query: 207 ------LEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAK-WKKDEKF-ERENILLQQ 258
LEE E + ++ Q+ +EK +Q+AK W+++EK E+E + +Q
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 449
Query: 259 KKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQ----HQSDTL---------Q 305
+KKM + + E E +KI E E QE+EE+ +Q H+ + + Q
Sbjct: 450 EKKMWR--QEEKIHEQEKIRE------EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQ 501
Query: 306 LEELRKTKEVPWR------------RDQINRHW--HDVLQQLLLMQVMQEELHAQALILE 351
E++RK +E WR R+Q + W + +++ M +E++H Q I E
Sbjct: 502 EEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWE 561
Query: 352 SLNTNLYYTQLELQKEKAIVGNLEKM--LQTKFAETEEKYKHTIQIL--TEENIHLKQKI 407
++ Q+EK I EK+ + K E EEK + + + EE I +++
Sbjct: 562 EEKRQEQEDKMWRQEEK-IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620
Query: 408 ISKNEE 413
I + EE
Sbjct: 621 IQEQEE 626
Score = 53.5 bits (127), Expect = 4e-07
Identities = 55/216 (25%), Positives = 104/216 (48%), Gaps = 21/216 (9%)
Query: 131 EEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELEN 190
EE++ E I E+ R Q K+ E +R E ++ + +++E E + E
Sbjct: 550 EEKMHEQEKIWEEEKRQEQE-DKMWRQEEKIR--EQEEKVWRQEEKIREQEEKRQEQEEK 606
Query: 191 NYKAALKAEKLAAQE-KLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKW-KKDEK 248
+K + EK+ QE K++E ++ + + R Q+ + E EEK +Q+ K +++EK
Sbjct: 607 MWK---QEEKIREQEEKIQEQEEKIREQEEKIRE-QEEMTQEQEEKMGEQEEKMCEQEEK 662
Query: 249 F-ERENILLQQKKKMTKKFEMESGEEDKKINESCSAV--FENFIQEKEELLKQHQSDTLQ 305
E+E + +Q++K+ E++KKI E + E +QE+EE + + + +
Sbjct: 663 MQEQEETMWRQEEKIR--------EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 714
Query: 306 LEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQE 341
EE + +E RR Q + W ++ + MQE
Sbjct: 715 QEEKMQEQEEKMRR-QEEKMWEQEVRLRQQEEKMQE 749
Score = 49.7 bits (117), Expect = 5e-06
Identities = 50/206 (24%), Positives = 99/206 (48%), Gaps = 14/206 (6%)
Query: 102 DEMFDRKKRWESEIPDKGR---FSRTNIISDLEEQI-SELTAIIEQMNRDHQSAQKLLSS 157
++M +++K WE E + + + I + EE++ + I EQ + + +K+
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610
Query: 158 EMDLRCAEMK-QNFENKNRELKEA-HEAELSELENNYKAALKAEKLAAQEKLEEMGKEYK 215
E +R E K Q E K RE +E E E E K + EK+ QE+ + +E
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670
Query: 216 YLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEK--FERENILLQQKKKMTKKFEMESGEE 273
+ + Q+ E EEK +Q+ ++ E+ +E+E + +Q++KM ++ E +E
Sbjct: 671 WRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 730
Query: 274 DKKINESCSAVFENFIQEKEELLKQH 299
+K + E ++++EE +++H
Sbjct: 731 EKMWEQ------EVRLRQQEEKMQEH 750
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 71.2 bits (173), Expect = 2e-12
Identities = 65/291 (22%), Positives = 144/291 (49%), Gaps = 13/291 (4%)
Query: 130 LEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELE 189
+E + SE+ ++++ R + A KLL + L+ E ++ K + E +EL
Sbjct: 294 VESEKSEIQLNVKELKRKLERA-KLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 352
Query: 190 NNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKF 249
N + + +EK++E ++ + + R ++ I ++ E+ +++ W+K+EK
Sbjct: 353 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 412
Query: 250 ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFE-NFIQEKEELLKQHQSDTLQLEE 308
R+ ++ +K++ ++ E E+++KI E + E I+E+EE K+ + + ++ +E
Sbjct: 413 RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE--KRQEEEKIREQE 470
Query: 309 LRKTKEVP-WRRDQ-INRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQK 366
R+ +E WR+++ I + +Q M +E++H Q I E Q E+ +
Sbjct: 471 KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQ---EQEEMWR 527
Query: 367 EKAIVGNLEKM--LQTKFAETEEKYKHTIQIL--TEENIHLKQKIISKNEE 413
++ + E++ + K E EEK + + + EE +H +++ I + EE
Sbjct: 528 QEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEE 578
Score = 68.2 bits (165), Expect = 1e-11
Identities = 71/357 (19%), Positives = 166/357 (46%), Gaps = 31/357 (8%)
Query: 69 RQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIIS 128
RQEE + + E I + +R +E+ + +E R++ E +K R + ++
Sbjct: 365 RQEEKIQEWEEKIQEQE--EKIREQEE-KIREQEEKMRRQEEMMWEKEEKMR-RQEEMMW 420
Query: 129 DLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSEL 188
+ EE++ ++ + + ++ + + +R E K+ E K RE ++ E E
Sbjct: 421 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW 480
Query: 189 ENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSK------QKAK 242
K + EK+ QE E+M ++ + + + ++ E EE W + Q+
Sbjct: 481 RQEEKIREQEEKIREQE--EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEI 538
Query: 243 WKKDEKF-ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVF--ENFIQEKEELLKQH 299
W++ EK E+E + +Q++KM ++ E + ++++KI E V+ E I+E+EE +++
Sbjct: 539 WRQKEKIHEQEEKIRKQEEKMWRQ-EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQ 597
Query: 300 QSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYY 359
+ + EE+ + +E +++ + +Q MQ +E++ Q + +
Sbjct: 598 EEKIREQEEMTQEQE-----EKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652
Query: 360 TQLELQKEKAIVGNLEKML----------QTKFAETEEKYKHTIQILTEENIHLKQK 406
+ ++++++ ++ E+ + + K E EEK + + + E+ + L+Q+
Sbjct: 653 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 709
Score = 60.8 bits (146), Expect = 2e-09
Identities = 66/297 (22%), Positives = 133/297 (44%), Gaps = 34/297 (11%)
Query: 53 QPTKPVVSPKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWE 112
Q K K++ RQE+ K + + + + +R +E+ +++ +++K E
Sbjct: 456 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIRE 515
Query: 113 SEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFEN 172
E + + EE+I E I Q + H+ +K+ E E
Sbjct: 516 EE-----KRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE------------EK 558
Query: 173 KNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEM 232
R+ ++ H+ E E K + EK+ QE E++ ++ + ++ Q+ + E
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIREQE--EKIREQEEKIRE-----QEEMTQEQ 611
Query: 233 EEKWSKQKAKW-KKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQE 291
EEK +Q+ K +++EK + + ++++++ ++ E + E+++KI E E +QE
Sbjct: 612 EEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-----EEMMQE 666
Query: 292 KEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHD---VLQQLLLMQVMQEELHA 345
+EE + + + + EE + +E RR Q + W + QQ MQ QE L A
Sbjct: 667 QEEKMWEQEEKMCEQEEKMQEQEEKMRR-QEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 54.7 bits (130), Expect = 2e-07
Identities = 64/305 (20%), Positives = 141/305 (46%), Gaps = 30/305 (9%)
Query: 102 DEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDL 161
+EM K+ E+ +K I + EE+ E I EQ R Q A K+ E +
Sbjct: 430 EEMMWEKEEKIRELEEK--MHEQEKIREQEEKRQEEEKIREQEKRQEQEA-KMWRQEEKI 486
Query: 162 RCAEMK--QNFENKNRELKEAHEAELSELENNYKAA----LKAEKLAAQEKL-------- 207
R E K + E R+ ++ HE E E + + EK+ QE++
Sbjct: 487 REQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIH 546
Query: 208 EEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKF-ERENILLQQKKKMTKKF 266
E+ K K + M+R ++ ++D+ E+ +++ W+++EK E+E + +Q++K+ ++
Sbjct: 547 EQEEKIRKQEEKMWRQ-EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQE 605
Query: 267 EMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHW 326
EM +E+K + E +++E++ +Q + Q E++R+ ++ +I
Sbjct: 606 EMTQEQEEKMGEQE-----EKMCEQEEKMQEQEEKMRRQEEKIREQEK------KIREQE 654
Query: 327 HDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETE 386
+ +Q +MQ +E++ Q + + + ++++++ + E L+ + + +
Sbjct: 655 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714
Query: 387 EKYKH 391
E +H
Sbjct: 715 EHQEH 719
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 68.6 bits (166), Expect = 1e-11
Identities = 80/403 (19%), Positives = 173/403 (42%), Gaps = 54/403 (13%)
Query: 20 RKLIKTPQLPRKNSTGSSKLTPLVPAPKNHNYLQPTKPVVSPKMKIHSAR--------QE 71
R I +L KN+ KL LV + K+ L V K K+ A+ Q
Sbjct: 199 RNTITDEELKEKNAKLQEKLQ-LVESEKSEIQLN----VKELKRKLERAKLLLPQQQLQA 253
Query: 72 ETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLE 131
E + E+ +VS Q ++ L + ++ R E +I + R I + E
Sbjct: 254 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE-----REEKIQEQE 308
Query: 132 EQISELTAII--------EQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEA 183
E+I E + E+ + + + + E +R E K + + K RE +E +
Sbjct: 309 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE 368
Query: 184 ELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKW 243
E E + +A+ +EK+ E ++ + + M + ++ + ++ E+ W +++
Sbjct: 369 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQ 428
Query: 244 KKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDT 303
+++EK R+ +++++K + E+++KI E E +QE+EE + + +
Sbjct: 429 EQEEKMRRQEEKIREQEKKIR-------EQEEKIREQ-----EEMMQEQEEKMGEQEGKM 476
Query: 304 LQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLE 363
+ E + +E RR + + +Q ++ +E++ Q +++ ++
Sbjct: 477 CEQEAKMQEQEEKMRRQE-----EKIREQEKKIREQEEKIREQEEMMQEQEEKMW----- 526
Query: 364 LQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQK 406
++E+ + EKM E EEK + + + E+ + L+Q+
Sbjct: 527 -EQEEKMCEQEEKM-----QEQEEKMRRQEEKMREQEVRLRQQ 563
Score = 49.3 bits (116), Expect = 7e-06
Identities = 46/233 (19%), Positives = 107/233 (45%), Gaps = 31/233 (13%)
Query: 53 QPTKPVVSPKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRK-KRW 111
Q K K++ RQE+ K + + + + +R +E++ ++M +++ K W
Sbjct: 362 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMW 421
Query: 112 ESEIPDKGRFSRTNIISDLEEQISELTA----IIEQMNRDHQSAQKLLSSEMDLRCAEMK 167
E E +++EQ ++ I EQ + + +K+ E EM
Sbjct: 422 EQE-------------EEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE------EMM 462
Query: 168 QNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQE-KLEEMGKEYKYLKNMFRTYQD 226
Q E K E E ++ E E K + EK+ QE K+ E K+ + + R ++
Sbjct: 463 QEQEEKMGE----QEGKMCEQEA--KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 227 SIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINE 279
+ ++ E+ W +++ +++EK + + ++++++ ++ E+ ++++K+ E
Sbjct: 517 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 65.1 bits (157), Expect = 1e-10
Identities = 76/348 (21%), Positives = 162/348 (46%), Gaps = 49/348 (14%)
Query: 93 REQISVTLGDEMFDRKKRWESEIPDKGRFSRTNI-ISDLEEQISELTAIIEQMNRDHQSA 151
+ Q+ V + + + ++K+ +S +K + + ++ ++EQ+ + ++Q ++ Q
Sbjct: 898 KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 152 QKLLSSEMDLRCAEMKQNFENKNRELKEAHEAEL-------SELENNYKAALK--AEKLA 202
Q ++ E+KQ+ E K +++ EA + EL +ELEN + L A++LA
Sbjct: 958 QGNIN--------ELKQSSEQKKKQI-EALQGELKIAVLQKTELENKLQQQLTQAAQELA 1008
Query: 203 AQ-EKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFE----------- 250
A+ EK+ + Y+ + F+ Q Y E + ++ +EK
Sbjct: 1009 AEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRN 1068
Query: 251 ---RENILLQQKKKMTKKFEMESGEEDKKINESCSAV----FENFIQEKEELLKQHQSDT 303
+N L+Q+ K E +S ++++++ E C A+ E ++EKE L +S
Sbjct: 1069 QIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKE--LVNEKSKL 1126
Query: 304 LQLEEL--RKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALIL----ESLNTNL 357
++EE+ R+ KE+ +++ H + ++++ ++ ++ L Q L L +SL +
Sbjct: 1127 AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV 1186
Query: 358 YYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQ 405
+ Q K V E+ L+ +F E E K I+ E+ + +K+
Sbjct: 1187 EQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIK---EKEVGMKK 1231
Score = 51.6 bits (122), Expect = 1e-06
Identities = 69/321 (21%), Positives = 145/321 (45%), Gaps = 22/321 (6%)
Query: 131 EEQISE--LTAIIEQMNRDHQSAQKLLS-SEMDLRCAEMKQNFENK-NRELKEAHEAELS 186
EE +S+ + A + Q + D Q Q LS SE L ++ + + + ++LKE ELS
Sbjct: 327 EESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE----ELS 382
Query: 187 ELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKD 246
E+E Y+ LKAE Q++ EE + L++ + E E + + + K+
Sbjct: 383 EVETKYQH-LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLL-ETERQLGEAHGRLKEQ 440
Query: 247 EKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSD-TLQ 305
+ E ++ ++++ + ++ EE K + S ++ + + ++ QHQ LQ
Sbjct: 441 RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ---QHQEQQALQ 497
Query: 306 LEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQ 365
K +E +Q+ R D Q++ ++ + ++ +LE +LY +
Sbjct: 498 QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGE 557
Query: 366 KEKAIVGNLEK---MLQTKFAETEEKYKHTIQI--LTEENIHLKQKIISKNEEICEGCSG 420
E A++ L++ LQ + + EK K+ + +EN+H + + + +
Sbjct: 558 GETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ---VQEQKAHLRAAQD 614
Query: 421 RLASITVSKDDSDTVQDGSKK 441
R+ S+ S ++ ++ + SK+
Sbjct: 615 RVLSLETSVNELNSQLNESKE 635
Score = 50.8 bits (120), Expect = 2e-06
Identities = 92/382 (24%), Positives = 163/382 (42%), Gaps = 60/382 (15%)
Query: 88 QLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRD 147
Q ++ + Q++ L + K+ E E K S T + DL+++ L +I +++ +
Sbjct: 751 QDLQQQRQLNTDLELRATELSKQLEME---KEIVSSTRL--DLQKKSEALESIKQKLTKQ 805
Query: 148 HQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKL 207
+ Q L KQ+FE ++E K HE EL N + + + EK
Sbjct: 806 EEEKQIL------------KQDFETLSQETKIQHE----ELNNRIQTTVTELQKVKMEK- 848
Query: 208 EEMGKEYKYLKNMFRTYQDSIYD---EMEEKWSKQKA----------KWKKDEKFERENI 254
E + E +K+ DS+ + E E++ K KA + K + + EN
Sbjct: 849 EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENT 908
Query: 255 LLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLE----ELR 310
L +Q K++ K E E E ++ +++ E IQ + LKQ++ + QL+ EL+
Sbjct: 909 LKEQ-KELKKSLEKEK-EASHQLKLELNSMQEQLIQ-AQNTLKQNEKEEQQLQGNINELK 965
Query: 311 KTKEVPWRRDQINRHWHD----VLQQLLLMQVMQEEL--HAQALILESLNTNLYYTQLEL 364
++ E ++ QI + VLQ+ L +Q++L AQ L E ++ E
Sbjct: 966 QSSE--QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023
Query: 365 QKEKAIVGNLEKMLQTKFAETEEKYKHTIQIL--TEENIHLKQKIISKNEEICEGCSGRL 422
+E K LQ+ F E + T Q L EE + L Q+ + N + +
Sbjct: 1024 SQETF------KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLI 1077
Query: 423 ASITVSKDDSDTVQDGSKKGQE 444
+ +K + QD +KK Q+
Sbjct: 1078 QELKTAK--ATLEQDSAKKEQQ 1097
Score = 49.3 bits (116), Expect = 7e-06
Identities = 77/298 (25%), Positives = 131/298 (43%), Gaps = 62/298 (20%)
Query: 130 LEEQISELTAIIEQMNRDHQSAQKLLSSEMD-----LRCAE-----MKQNFENKNRELKE 179
L+EQ+++LT ++ + H+ AQ+ L ++ LR A+ ++ + N +L E
Sbjct: 573 LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632
Query: 180 AHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQ 239
+ E ++S+L+ KA K E L + E + + L+N T Q+++ D+ +E
Sbjct: 633 SKE-KVSQLDIQIKA--KTELLLSAEAAKT--AQRADLQNHLDTAQNALQDKQQEL---- 683
Query: 240 KAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQH 299
N + Q ++T K +DK+ E CS + E LK++
Sbjct: 684 -------------NKITTQLDQVTAKL------QDKQ--EHCS--------QLESHLKEY 714
Query: 300 QSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYY 359
+ L LE+ KT+E+ QI + D L+ + ++L Q LNT+L
Sbjct: 715 KEKYLSLEQ--KTEEL---EGQIKKLEADSLEVKASKEQALQDLQQQ----RQLNTDLEL 765
Query: 360 TQLELQK----EKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEE 413
EL K EK IV + LQ K +E E K + EE LKQ + ++E
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKK-SEALESIKQKLTKQEEEKQILKQDFETLSQE 822
Score = 42.0 bits (97), Expect = 0.001
Identities = 60/312 (19%), Positives = 128/312 (41%), Gaps = 48/312 (15%)
Query: 107 RKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEM--DLRCA 164
++++W SE K L++Q ++ ++ + + QS ++ L +
Sbjct: 100 KEEKWYSEELKK----ELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIK 155
Query: 165 EMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTY 224
+MK FE K +L E++++++ Y ++ + AA++K+ + +E L
Sbjct: 156 QMKDLFEQKAAQLA----TEIADIKSKYDEE-RSLREAAEQKVTRLTEE---LNKEATVI 207
Query: 225 QDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAV 284
QD + ++ + A KK+ L Q + + +E E +K+ + C +
Sbjct: 208 QDLKTELLQRPGIEDVAVLKKE---------LVQVQTLMDNMTLERERESEKLKDECKKL 258
Query: 285 FENFI-------QEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVL------- 330
+ Q + EL K Q + ++EL+K K Q N+ + L
Sbjct: 259 QSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDY 318
Query: 331 --------QQLLLMQVMQEELHAQALILESLNTNLYYTQLELQK---EKAIVGNLEKMLQ 379
++ + + +Q LH + L + L + L ++ L + E + G + L+
Sbjct: 319 TKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLK 378
Query: 380 TKFAETEEKYKH 391
+ +E E KY+H
Sbjct: 379 EELSEVETKYQH 390
Score = 33.9 bits (76), Expect = 0.31
Identities = 36/168 (21%), Positives = 75/168 (44%), Gaps = 23/168 (13%)
Query: 129 DLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENK----NRELKE----- 179
+L+ + L A +EQ R+ Q++L ++ E+K+ F K + E+KE
Sbjct: 1174 ELQGKADSLKAAVEQEKRN----QQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGM 1229
Query: 180 -AHEAELSELE------NNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEM 232
HE ++L N +K E ++Q ++ E+ K+ L+ + ++ +
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQ 1289
Query: 233 EEKWSKQKAKWKKD---EKFERENILLQQKKKMTKKFEMESGEEDKKI 277
+E+ + + K + EK + + + LQ+K T E G E++ +
Sbjct: 1290 DERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSL 1337
>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
Length = 495
Score = 63.9 bits (154), Expect = 3e-10
Identities = 70/287 (24%), Positives = 132/287 (45%), Gaps = 39/287 (13%)
Query: 133 QISELTAI-IEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENN 191
QI+E AI EQM RD + A+ ++ E R + + E+K + K + +L +
Sbjct: 140 QIAEKDAIKYEQMKRDAEIAKTMM--EEHKRIIKEENAAEDKRNKAKAQYYLDLEK---- 193
Query: 192 YKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFER 251
L+ ++ QE E++ KE + + R + E ++K K A + E+F++
Sbjct: 194 ---QLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQK 250
Query: 252 ENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEE----LLKQHQSDTLQL- 306
E L ++KK+ EME EE++KI E F N Q++EE +++++ LQL
Sbjct: 251 EQALWRKKKRE----EME--EENRKIIE-----FANMQQQREEDRMAKVQENEEKRLQLQ 299
Query: 307 --------EELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLY 358
E LR+ +++ R ++ + + + L + +++L Q + + +
Sbjct: 300 NALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMA 359
Query: 359 YTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQ 405
+L LQ K N K + KFAE + I+++ + +KQ
Sbjct: 360 LKELVLQAAKEEEENFRKTMLAKFAEDDR-----IELMNAQKQRMKQ 401
Score = 56.2 bits (134), Expect = 6e-08
Identities = 64/266 (24%), Positives = 124/266 (46%), Gaps = 33/266 (12%)
Query: 129 DLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNF--ENKNRELKEAHEAELS 186
D+EE I + + N+ + Q ++ + A++K + K R+ + EL
Sbjct: 68 DMEEAIQKA-----EENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELR 122
Query: 187 ELENNYKAALKAEKLAAQ------EKLEEMGKEYKYLKNMFRTYQDSIYDE--MEEKWSK 238
ELE KAA ++ AAQ K E+M ++ + K M ++ I +E E+K +K
Sbjct: 123 ELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNK 182
Query: 239 QKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQ 298
KA++ D E L +Q+KK + +E + +E I+E ++E EK++ L++
Sbjct: 183 AKAQYYLD----LEKQLEEQEKKKQEAYE-QLLKEKLMIDEIVRKIYEEDQLEKQQKLEK 237
Query: 299 HQSDTLQLEELRKTKEVPWR---RDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNT 355
+ +EE +K ++ WR R+++ +++ + Q +E+ A+ E
Sbjct: 238 MNAMRRYIEEFQK-EQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENE---- 292
Query: 356 NLYYTQLELQKEKAIVGNLEKMLQTK 381
+ LQ + A+ LE+ML+ +
Sbjct: 293 -----EKRLQLQNALTQKLEEMLRQR 313
Score = 41.6 bits (96), Expect = 0.001
Identities = 39/197 (19%), Positives = 87/197 (44%), Gaps = 19/197 (9%)
Query: 104 MFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRC 163
++ +KKR E E ++ N+ EE + A +++ Q L+ +++
Sbjct: 254 LWRKKKREEMEEENRKIIEFANMQQQREE---DRMAKVQENEEKRLQLQNALTQKLE-EM 309
Query: 164 AEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRT 223
+++ E +EL + +AE+ YK+ LK E K +EM ++++ +
Sbjct: 310 LRQREDLEQVRQELYQEEQAEI------YKSKLKEEAEKKLRKQKEMKQDFEEQMALKEL 363
Query: 224 YQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSA 283
+ +E E AK+ +D++ E N Q+ K++ + +E E+++
Sbjct: 364 VLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERR------- 416
Query: 284 VFENFIQEKEELLKQHQ 300
+ F+ +K+ L++ Q
Sbjct: 417 --QQFLADKQRELEEWQ 431
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 63.5 bits (153), Expect = 4e-10
Identities = 76/331 (22%), Positives = 161/331 (48%), Gaps = 40/331 (12%)
Query: 117 DKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRE 176
DK + ++ +LE++++++ + + ++ + Q+ +++E+++ E KQ+ ++K E
Sbjct: 255 DKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEK-QQCMATELEMTVKEAKQD-KSKEAE 312
Query: 177 LKEAHEAELSELENNYKAALKAEKLAAQEKL---EEMGKEYKYLKNMFRTYQDSIYDEME 233
K A +AE+ +L+N+ + A + E+LAAQ+ EE +L++ R Q +
Sbjct: 313 CK-ALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLL---- 367
Query: 234 EKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKE 293
KQKA ++ +RE +LQ++ M +K E K++ E E
Sbjct: 368 --LDKQKA--DTIQELQRELQMLQKESSMAEK---EQTSNRKRV--------EELSLELS 412
Query: 294 ELLKQHQSDTLQLEELRKT--KEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILE 351
E L++ ++ + +L+KT ++ D ++R H +Q + ++E+L +LE
Sbjct: 413 EALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLE 472
Query: 352 SLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKN 411
L ++ + EK + G LE + Q +F + ++ K + L EEN +L+ ++
Sbjct: 473 DKREQLKKSK---EHEKLMEGELEALRQ-EFKKKDKTLKENSRKLEEENENLRAEL---- 524
Query: 412 EEICEGCSGRL-ASITVSKDDSDTVQDGSKK 441
+ CS +L +S+ +QD +K+
Sbjct: 525 ----QCCSTQLESSLNKYNTSQQVIQDLNKE 551
Score = 43.9 bits (102), Expect = 3e-04
Identities = 52/238 (21%), Positives = 109/238 (45%), Gaps = 22/238 (9%)
Query: 88 QLVRNREQISVTLGD-----EMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIE 142
QL +++E + G+ + F +K + E K N+ ++L+ ++L + +
Sbjct: 477 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 536
Query: 143 QMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNREL-KEAHEAELSELENNYKAALKAEKL 201
+ N Q Q L + E+ L+ + ++ L KE H + + + Y A L +
Sbjct: 537 KYNTSQQVIQDL-NKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDA-LSRKSA 594
Query: 202 AAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKK 261
A Q+ L + ++ ++ + ++ Q S+ E+K ++ +E+ ++ N L++ +
Sbjct: 595 ACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRG 654
Query: 262 MTKKFEMESGEEDKKINE-SCSAVFENFIQEKEELLKQHQSDTLQL----EELRKTKE 314
++ E+E DKK+ E SC + + KQHQ+D L E+LR+ +E
Sbjct: 655 FHQESELEVHAFDKKLEEMSCQVL---------QWQKQHQNDLKMLAAKEEQLREFQE 703
Score = 35.4 bits (80), Expect = 0.11
Identities = 64/292 (21%), Positives = 121/292 (41%), Gaps = 32/292 (10%)
Query: 147 DHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEK 206
D + K L + D +C +++ ++N ++L+ EA + N K +K E L
Sbjct: 158 DIKKILKHLQEQKDSQCLHVEE-YQNLVKDLRVELEAVSEQKRNIMKDMMKLE-LDLHGL 215
Query: 207 LEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQ-KKKMTKK 265
EE + Q + + E QK KKD+ + ++ +LQ+ +KK+T+
Sbjct: 216 REETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQV 275
Query: 266 FEMESGEEDKKINESCSAV-FENFIQE-KEELLKQHQSDTLQLEELRKTKEVPWRRDQIN 323
+E + + C A E ++E K++ K+ + LQ E + + + Q
Sbjct: 276 QNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQ-- 333
Query: 324 RHWHDVLQQLLLMQVMQ--EELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTK 381
++L Q Q EE LE TQ +LQK +L +
Sbjct: 334 -------ERLAAQQAAQCKEEAALAGCHLED-------TQRKLQK--------GLLLDKQ 371
Query: 382 FAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSGRLASITVSKDDSD 433
A+T ++ + +Q+L +E+ + +K + N + E S L+ ++SD
Sbjct: 372 KADTIQELQRELQMLQKES-SMAEKEQTSNRKRVEELSLELSEALRKLENSD 422
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 63.5 bits (153), Expect = 4e-10
Identities = 76/331 (22%), Positives = 161/331 (48%), Gaps = 40/331 (12%)
Query: 117 DKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRE 176
DK + ++ +LE++++++ + + ++ + Q+ +++E+++ E KQ+ ++K E
Sbjct: 400 DKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEK-QQCMATELEMTVKEAKQD-KSKEAE 457
Query: 177 LKEAHEAELSELENNYKAALKAEKLAAQEKL---EEMGKEYKYLKNMFRTYQDSIYDEME 233
K A +AE+ +L+N+ + A + E+LAAQ+ EE +L++ R Q +
Sbjct: 458 CK-ALQAEVQKLKNSLEEAKQQERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLL---- 512
Query: 234 EKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKE 293
KQKA ++ +RE +LQ++ M +K E K++ E E
Sbjct: 513 --LDKQKA--DTIQELQRELQMLQKESSMAEK---EQTSNRKRV--------EELSLELS 557
Query: 294 ELLKQHQSDTLQLEELRKT--KEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILE 351
E L++ ++ + +L+KT ++ D ++R H +Q + ++E+L +LE
Sbjct: 558 EALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQEATKLLE 617
Query: 352 SLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKN 411
L ++ + EK + G LE + Q +F + ++ K + L EEN +L+ ++
Sbjct: 618 DKREQLKKSK---EHEKLMEGELEALRQ-EFKKKDKTLKENSRKLEEENENLRAEL---- 669
Query: 412 EEICEGCSGRL-ASITVSKDDSDTVQDGSKK 441
+ CS +L +S+ +QD +K+
Sbjct: 670 ----QCCSTQLESSLNKYNTSQQVIQDLNKE 696
Score = 43.9 bits (102), Expect = 3e-04
Identities = 52/238 (21%), Positives = 109/238 (45%), Gaps = 22/238 (9%)
Query: 88 QLVRNREQISVTLGD-----EMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIE 142
QL +++E + G+ + F +K + E K N+ ++L+ ++L + +
Sbjct: 622 QLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCSTQLESSLN 681
Query: 143 QMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNREL-KEAHEAELSELENNYKAALKAEKL 201
+ N Q Q L + E+ L+ + ++ L KE H + + + Y A L +
Sbjct: 682 KYNTSQQVIQDL-NKEIALQKESLMSLQAQLDKALQKEKHYLQTTITKEAYDA-LSRKSA 739
Query: 202 AAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKK 261
A Q+ L + ++ ++ + ++ Q S+ E+K ++ +E+ ++ N L++ +
Sbjct: 740 ACQDDLTQALEKLNHVTSETKSLQQSLTQTQEKKAQLEEEIIAYEERMKKLNTELRKLRG 799
Query: 262 MTKKFEMESGEEDKKINE-SCSAVFENFIQEKEELLKQHQSDTLQL----EELRKTKE 314
++ E+E DKK+ E SC + + KQHQ+D L E+LR+ +E
Sbjct: 800 FHQESELEVHAFDKKLEEMSCQVL---------QWQKQHQNDLKMLAAKEEQLREFQE 848
Score = 35.4 bits (80), Expect = 0.11
Identities = 64/292 (21%), Positives = 121/292 (41%), Gaps = 32/292 (10%)
Query: 147 DHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEK 206
D + K L + D +C +++ ++N ++L+ EA + N K +K E L
Sbjct: 303 DIKKILKHLQEQKDSQCLHVEE-YQNLVKDLRVELEAVSEQKRNIMKDMMKLE-LDLHGL 360
Query: 207 LEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQ-KKKMTKK 265
EE + Q + + E QK KKD+ + ++ +LQ+ +KK+T+
Sbjct: 361 REETSAHIERKDKDITILQCRLQELQLEFTETQKLTLKKDKFLQEKDEMLQELEKKLTQV 420
Query: 266 FEMESGEEDKKINESCSAV-FENFIQE-KEELLKQHQSDTLQLEELRKTKEVPWRRDQIN 323
+E + + C A E ++E K++ K+ + LQ E + + + Q
Sbjct: 421 QNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAECKALQAEVQKLKNSLEEAKQQ-- 478
Query: 324 RHWHDVLQQLLLMQVMQ--EELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTK 381
++L Q Q EE LE TQ +LQK +L +
Sbjct: 479 -------ERLAAQQAAQCKEEAALAGCHLED-------TQRKLQK--------GLLLDKQ 516
Query: 382 FAETEEKYKHTIQILTEENIHLKQKIISKNEEICEGCSGRLASITVSKDDSD 433
A+T ++ + +Q+L +E+ + +K + N + E S L+ ++SD
Sbjct: 517 KADTIQELQRELQMLQKES-SMAEKEQTSNRKRVEELSLELSEALRKLENSD 567
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/323 (25%), Positives = 147/323 (45%), Gaps = 47/323 (14%)
Query: 130 LEEQISELTAIIEQMNRDHQS----------AQKLLSSEMDLRCAEMKQNFENKNRELKE 179
LE+ + EL+ EQ+ R Q+ A K LS+ DL+ + + K ELK
Sbjct: 530 LEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK- 588
Query: 180 AHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQ 239
HEAE++ NYK L+ + L+ M + + RT + EE+ SK
Sbjct: 589 -HEAEVT----NYKIKLEMLEKEKNAVLDRMAESQEAELERLRT---QLLFSHEEELSKL 640
Query: 240 KAKWKKDEKFE----RENILLQQKKK-------MTKKFEMESGEEDKKINESCSAVFE-N 287
K + + + ++N+ + K++ M++K E E+D I + + E +
Sbjct: 641 KEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS 700
Query: 288 FIQEKEELLKQHQSD--TLQLEELRKTKEVPWRRDQINRHWHDVLQQLLL--------MQ 337
+++ ++ L +S+ TLQ+ EL+K E+ + ++ +Q+L L M+
Sbjct: 701 KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMK 760
Query: 338 VMQEELHAQALILESLNTNLYYTQLELQKEKAI---VGNLEKMLQTKFAETEEK---YKH 391
+ +L + LE+ N+ L + L+ I V E+++ +++ K ++
Sbjct: 761 EKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEK 820
Query: 392 TIQILTEENIHLKQKIISKNEEI 414
I+IL EEN LKQ+ I NEEI
Sbjct: 821 EIEILIEENEDLKQQCIQLNEEI 843
Score = 53.1 bits (126), Expect = 5e-07
Identities = 62/302 (20%), Positives = 131/302 (43%), Gaps = 20/302 (6%)
Query: 125 NIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAE 184
N + + ++ SEL EQ+ RD Q + + +++ R E++Q ++ + +
Sbjct: 2116 NHLKEKTDKCSELLLSKEQLQRDIQERNEEIE-KLEFRVRELEQALLVSADTFQKVEDRK 2174
Query: 185 -LSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWS------ 237
+E + +L+ + A ++ ++ KE L+ +++ + ++ EE
Sbjct: 2175 HFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLE 2234
Query: 238 -KQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENF---IQEKE 293
++K + ++ E+EN L K +K + E D + +F F IQEKE
Sbjct: 2235 IQKKESTTRLQELEQENKLF---KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKE 2291
Query: 294 ELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHA-QALILES 352
+ Q +L++ K ++ N D+ Q+ + QE + + +E
Sbjct: 2292 VEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQ 2351
Query: 353 LNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNE 412
LN + +LQ+E A +G M +E + KH + ++ E + L+Q++ + NE
Sbjct: 2352 LNEVIE----KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANE 2407
Query: 413 EI 414
E+
Sbjct: 2408 EM 2409
Score = 49.3 bits (116), Expect = 7e-06
Identities = 76/341 (22%), Positives = 151/341 (44%), Gaps = 35/341 (10%)
Query: 91 RNREQISVTLG------DEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQM 144
R REQ++V L D D K +E +I +K T+II LE+++ + ++++
Sbjct: 1908 RAREQLAVELSKAEGVIDGYADEKTLFERQIQEK-----TDIIDRLEQELLCASNRLQEL 1962
Query: 145 NRDHQSAQK---LLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKL 201
+ Q Q+ LLS + + AE + + L+E + +LE +A + L
Sbjct: 1963 EAEQQQIQEERELLSRQKEAMKAEAGPV---EQQLLQETEKLMKEKLEVQCQAEKVRDDL 2019
Query: 202 AAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQ--KAKWKKDEKFERENILLQQK 259
Q K E+ E + + Q+ + M+ + Q + + +K KF E + ++
Sbjct: 2020 QKQVKALEIDVE-EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH 2078
Query: 260 KKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKE----- 314
++ + E++ E+ K+ + E+ +E E+L + T + EL +KE
Sbjct: 2079 ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRD 2138
Query: 315 VPWRRDQINRHWHDV--LQQLLLM-----QVMQEELHAQALILE---SLNTNLYYTQLEL 364
+ R ++I + V L+Q LL+ Q +++ H A+ + SL L + +
Sbjct: 2139 IQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAI 2198
Query: 365 QKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQ 405
+++ + NLE+ L+ E E K + Q+ + I K+
Sbjct: 2199 DRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE 2239
Score = 45.4 bits (106), Expect = 1e-04
Identities = 77/340 (22%), Positives = 137/340 (40%), Gaps = 61/340 (17%)
Query: 131 EEQISELTAIIEQMNRDH--QSAQKLLSSEMDLR-----CAEMKQNFENKNRELKEAHEA 183
+ +I EL +E+M + + Q+L E ++ ++ N + RE E
Sbjct: 168 QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227
Query: 184 ELSELENNYKAALKAEKLAAQEKLEEM-----GKEYKYLKNMFRTYQDSIYDEMEEKWSK 238
L E + K ++ ++L A E L + K T+Q ++EE+
Sbjct: 228 FLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQ----QLEEQDHL 283
Query: 239 QKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQ 298
+ KK E F + LQ+K K+ +EME ++ + N+ E I+E + +
Sbjct: 284 LEDYQKKKEDFTMQISFLQEKIKV---YEMEQDKKVENSNKEEIQEKETIIEELNTKIIE 340
Query: 299 HQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNT--- 355
+ TL+L++ T D L L Q++Q+ + + LE N+
Sbjct: 341 EEKKTLELKDKLTTA--------------DKLLGELQEQIVQKNQEIKNMKLELTNSKQK 386
Query: 356 ---------NLYYTQLELQK--------EKAIVGNLEKMLQTKF----AETEEKYKHTIQ 394
L T ELQK E IV +E+ Q K AE +E Y I
Sbjct: 387 ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIV 446
Query: 395 ILTEENI--HLKQ--KIISKNEEICEGCSGRLASITVSKD 430
+ +E I H+ Q ++ ++++ E ++ITV++D
Sbjct: 447 QMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNED 486
Score = 45.4 bits (106), Expect = 1e-04
Identities = 67/344 (19%), Positives = 159/344 (46%), Gaps = 30/344 (8%)
Query: 79 EVINVSPGYQLVRNREQISVT---LGDEMFDRKKRW------ESEIPDKGRFSRTNIISD 129
E+++ S + + + + VT + EM +++K ES+ + R RT ++
Sbjct: 574 EIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL-RTQLLFS 632
Query: 130 LEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELE 189
EE++S+L E + +H+ + L + + KQ + E+ + + E + E
Sbjct: 633 HEEELSKLK---EDLEIEHRINIEKLKDNLGIH---YKQQIDGLQNEMSQ--KIETMQFE 684
Query: 190 NNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQ-DSIYDEMEEKWSKQKAKWKKDEK 248
+ + + + KL+++ + K+ T Q + + E+E ++K K +++
Sbjct: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744
Query: 249 FERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQH-----QSDT 303
+ + + +K K+ E + E+ ++ E+ +++ ++ + E++LK H +
Sbjct: 745 VQELQLKTELLEKQMKEKENDLQEKFAQL-EAENSILKDEKKTLEDMLKIHTPVSQEERL 803
Query: 304 LQLEELR-KTKEVPWRRD-QINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQ 361
+ L+ ++ K+K+ W ++ +I ++ L+Q + + EE+ Q N
Sbjct: 804 IFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ--LNEEIEKQRNTFSFAEKNFEVNY 861
Query: 362 LELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQ 405
ELQ+E A + ++ L+ + E +YK ++ L EE +HL++
Sbjct: 862 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEE-LHLQR 904
Score = 45.4 bits (106), Expect = 1e-04
Identities = 75/369 (20%), Positives = 168/369 (45%), Gaps = 48/369 (13%)
Query: 88 QLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRD 147
Q+++ +E L +++ +++ + +K + +I DLE QI L + E + R+
Sbjct: 2285 QIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN 2344
Query: 148 HQSAQKLLSSEMDLRCAEMKQNFENKNRELK-EAHEAELSELENNYKAALK---AEKLAA 203
+ + L+ ++ +++Q N ++ AH LSE ++ K L AEKLA
Sbjct: 2345 REEEIEQLNEVIE----KLQQELANIGQKTSMNAHS--LSEEADSLKHQLDVVIAEKLAL 2398
Query: 204 QEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFE-----RENILLQQ 258
++++E +E ++KN+ + + +E +S ++ + + EK + N+ +
Sbjct: 2399 EQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER-ESVEKIQSIPENSVNVAIDH 2457
Query: 259 KKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLE------ELRKT 312
K + E+ E+ K E+ F++F + + + ++ LQLE +L T
Sbjct: 2458 LSKDKPELEVVLTEDALKSLEN-QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELT 2516
Query: 313 ---KEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALI----LESLNTNLYYTQ---- 361
K++ ++Q + ++++ +Q + EE A AL+ LE++ + Q
Sbjct: 2517 QCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2576
Query: 362 LELQKEKAIVGNLEKM-----------LQTKFAETEEKY--KHTIQILTEENIHLKQK-I 407
+ + E+ + NL ++ L + +E E + HT IL +E + + +K +
Sbjct: 2577 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2636
Query: 408 ISKNEEICE 416
+ K +++ E
Sbjct: 2637 LEKEKKLLE 2645
Score = 44.3 bits (103), Expect = 2e-04
Identities = 54/260 (20%), Positives = 119/260 (45%), Gaps = 36/260 (13%)
Query: 88 QLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRD 147
+++R E+ TL E+ ++ + ++E+ +K + N DL+E+ ++L A + +
Sbjct: 729 EILRQEEKEKGTLEQEV--QELQLKTELLEKQMKEKEN---DLQEKFAQLEAENSILKDE 783
Query: 148 HQSAQKLLSSEMDLRCAE---MKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQ 204
++ + +L + E + ++K+++ E E+ EN LK + +
Sbjct: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE---DLKQQCIQLN 840
Query: 205 EKLEEMGKEYKYLKNMFRT-YQD---------SIYDEMEEKWSKQKAKWKKDEKFERENI 254
E++E+ + + + F YQ+ + D++E+ +KQ+ ++K K E +
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 255 LLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQL-EELRKTK 313
LQ+ T K + +EDK F+ E E+ + + DT +L E+L TK
Sbjct: 901 HLQRINPTTVKMKSSVFDEDK-----------TFVAETLEMGEVVEKDTTELMEKLEVTK 949
Query: 314 EVPWRRDQINRHWHDVLQQL 333
+ ++++ D+ +QL
Sbjct: 950 R---EKLELSQRLSDLSEQL 966
Score = 40.4 bits (93), Expect = 0.003
Identities = 76/337 (22%), Positives = 153/337 (45%), Gaps = 49/337 (14%)
Query: 108 KKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMN------RDHQSAQKLLSSEMDL 161
K+ ESE P + I + Q+ E+ + M ++ S++K++ +E+
Sbjct: 3109 KREQESEKPSQELLEYN--IQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKS 3166
Query: 162 RCAEMKQNFEN----KNRELKEAHEAELSELENNYKAALKAEKLAA-QEKLEEMGKEYKY 216
A+ K E +++ LKE L + + L + LA+ Q+K E+ +
Sbjct: 3167 ELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK 3226
Query: 217 LKNMFRTYQDSIYDEMEE-KWSKQKAKWKKDEKFERENILLQQKKKM----TKKFEMESG 271
K ++ +E+E+ K+S + K ++ + N+LL+Q+K++ +K E +
Sbjct: 3227 EKAKLGRSEERDKEELEDLKFSLESQK----QRNLQLNLLLEQQKQLLNESQQKIESQRM 3282
Query: 272 EEDKKINESCSAVFE-NFIQEKEELLKQHQSDTLQLE-----ELRKTKEVPWRRDQINRH 325
D +++E E + E E++ + S TL E +L+ + R +
Sbjct: 3283 LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS- 3341
Query: 326 WHDVLQQLLLMQVMQEELHAQALILESLNTNLYY------TQLELQKEKAIVGNLEKMLQ 379
D+L++L Q EE H++ I+E LN Y T+ +++K++ + K LQ
Sbjct: 3342 -EDLLKEL---QKQLEEKHSR--IVELLNETEKYKLDSLQTRQQMEKDRQV---HRKTLQ 3392
Query: 380 T-KFAETE-EKYKHTIQILTEENIHLKQKIISKNEEI 414
T + A TE +K H +Q E+ L++++ K +++
Sbjct: 3393 TEQEANTEGQKKMHELQSKVED---LQRQLEEKRQQV 3426
Score = 35.0 bits (79), Expect = 0.14
Identities = 43/182 (23%), Positives = 84/182 (46%), Gaps = 16/182 (8%)
Query: 98 VTLGDEMFDRKKRW--ESEIPDKGRFSRTNIISDL---EEQISELTAIIEQMNRDHQSAQ 152
+T+ +EMF + K + I D+ S + L EEQ+ ++ + + ++HQ A
Sbjct: 1546 LTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQAT 1605
Query: 153 KLLSSEMDLRCAEMKQNFENKNRELKEAHE--AELSELEN----NYKAALKAEKLAAQEK 206
+LL + +++ E E+K + A+ S ++N + + + E+L A ++
Sbjct: 1606 ELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQ 1665
Query: 207 LEEMGKEYK--YLKNMFRTYQDSIYD--EMEEKWSKQKAKWKKDEKFERENILLQQKKKM 262
L G+E L+N Q+ + E+EE+ K+K +K E E IL ++ +
Sbjct: 1666 LSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPE-ILSNERYAL 1724
Query: 263 TK 264
K
Sbjct: 1725 QK 1726
Score = 33.9 bits (76), Expect = 0.31
Identities = 62/347 (17%), Positives = 151/347 (43%), Gaps = 36/347 (10%)
Query: 106 DRKKRWESEIPDKGRFSRTNIISDLEEQIS-ELTAIIEQMNRDHQSAQKLLSSEMDLRCA 164
++ K SE DK + ++Q + +L ++EQ + +Q+ + S+ L A
Sbjct: 3227 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3286
Query: 165 EMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQ-EKLEEMGKEYKYLKNMFRT 223
++ + + +N EL+ E+E + + +L AQ + + G+ L +
Sbjct: 3287 QLSEE-QGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS--ED 3343
Query: 224 YQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSA 283
+ ++EEK S+ + EK++ ++ LQ +++M E+D++++
Sbjct: 3344 LLKELQKQLEEKHSRIVELLNETEKYKLDS--LQTRQQM---------EKDRQVHRKTLQ 3392
Query: 284 VFENFIQEKEELLKQHQSDTLQLE-ELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEE 342
+ E ++ + + QS L+ +L + ++ ++ D + ++Q+ ++ +EE
Sbjct: 3393 TEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREE 3452
Query: 343 -LHAQALILESLN-----------TNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYK 390
++ ++ ++LN T + Q +++ E N K+++ T
Sbjct: 3453 KRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETK-ESNYAKLIEMNGGGT--GCN 3509
Query: 391 HTIQILTEENIHLKQKIISKNEEICEGCSGRLASITVSKDDSDTVQD 437
H ++++ ++ Q + SK + + + S RL T +D VQ+
Sbjct: 3510 HELEMIRQK----LQCVASKLQVLPQKASERLQFETADDEDFIWVQE 3552
Score = 30.4 bits (67), Expect = 3.4
Identities = 47/258 (18%), Positives = 110/258 (42%), Gaps = 30/258 (11%)
Query: 130 LEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELE 189
L+++I L I+E+ L S++ L + F N+ + E E + ++
Sbjct: 2536 LQKKIVNLQKIVEE------KVAAALVSQIQLEAVQEYAKFCQDNQTISS--EPERTNIQ 2587
Query: 190 NNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKF 249
N + L+ ++L + + + L++ S+ E E+ +K +K++K
Sbjct: 2588 NLNQ--LREDELGSD--ISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKL 2643
Query: 250 ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEEL 309
LL+ +K ++ E + +D ++ ++ + +F + EE ++ + L+ E +
Sbjct: 2644 LELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHS----NEESGFFNELEALRAESV 2699
Query: 310 RKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKA 369
E+ +++ + +QEEL + + SL +L + L + K
Sbjct: 2700 ATKAELASYKEKAEK--------------LQEELLVKETNMTSLQKDLSQVRDHLAEAKE 2745
Query: 370 IVGNLEKMLQTKFAETEE 387
+ LEK +T+ E+++
Sbjct: 2746 KLSILEKEDETEVQESKK 2763
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/323 (25%), Positives = 147/323 (45%), Gaps = 47/323 (14%)
Query: 130 LEEQISELTAIIEQMNRDHQS----------AQKLLSSEMDLRCAEMKQNFENKNRELKE 179
LE+ + EL+ EQ+ R Q+ A K LS+ DL+ + + K ELK
Sbjct: 530 LEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELK- 588
Query: 180 AHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQ 239
HEAE++ NYK L+ + L+ M + + RT + EE+ SK
Sbjct: 589 -HEAEVT----NYKIKLEMLEKEKNAVLDRMAESQEAELERLRT---QLLFSHEEELSKL 640
Query: 240 KAKWKKDEKFE----RENILLQQKKK-------MTKKFEMESGEEDKKINESCSAVFE-N 287
K + + + ++N+ + K++ M++K E E+D I + + E +
Sbjct: 641 KEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEIS 700
Query: 288 FIQEKEELLKQHQSD--TLQLEELRKTKEVPWRRDQINRHWHDVLQQLLL--------MQ 337
+++ ++ L +S+ TLQ+ EL+K E+ + ++ +Q+L L M+
Sbjct: 701 KLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMK 760
Query: 338 VMQEELHAQALILESLNTNLYYTQLELQKEKAI---VGNLEKMLQTKFAETEEK---YKH 391
+ +L + LE+ N+ L + L+ I V E+++ +++ K ++
Sbjct: 761 EKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEK 820
Query: 392 TIQILTEENIHLKQKIISKNEEI 414
I+IL EEN LKQ+ I NEEI
Sbjct: 821 EIEILIEENEDLKQQCIQLNEEI 843
Score = 54.3 bits (129), Expect = 2e-07
Identities = 65/301 (21%), Positives = 133/301 (44%), Gaps = 26/301 (8%)
Query: 125 NIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAE 184
N + + ++ SEL EQ+ RD Q + + +++ R E++Q ++R+ A EA+
Sbjct: 2116 NHLKEKTDKCSELLLSKEQLQRDIQERNEEIE-KLEFRVRELEQALLVEDRKHFGAVEAK 2174
Query: 185 LSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWS------- 237
+ +L+ + A ++ ++ KE L+ +++ + ++ EE
Sbjct: 2175 P-------ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2227
Query: 238 KQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENF---IQEKEE 294
++K + ++ E+EN L K +K + E D + +F F IQEKE
Sbjct: 2228 QKKESTTRLQELEQENKLF---KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2284
Query: 295 LLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHA-QALILESL 353
+ Q +L++ K ++ N D+ Q+ + QE + + +E L
Sbjct: 2285 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQL 2344
Query: 354 NTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEE 413
N + +LQ+E A +G M +E + KH + ++ E + L+Q++ + NEE
Sbjct: 2345 NEVIE----KLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEE 2400
Query: 414 I 414
+
Sbjct: 2401 M 2401
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/335 (22%), Positives = 151/335 (45%), Gaps = 35/335 (10%)
Query: 91 RNREQISVTLG------DEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQM 144
R REQ++V L D D K +E +I +K T+II LE+++ + ++++
Sbjct: 1908 RAREQLAVELSKAEGVIDGYADEKTLFERQIQEK-----TDIIDRLEQELLCASNRLQEL 1962
Query: 145 NRDHQSAQK---LLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKL 201
+ Q Q+ LLS + + AE + + L+E + +LE +A + L
Sbjct: 1963 EAEQQQIQEERELLSRQKEAMKAEAGPV---EQQLLQETEKLMKEKLEVQCQAEKVRDDL 2019
Query: 202 AAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQ--KAKWKKDEKFERENILLQQK 259
Q K E+ E + + Q+ + M+ + Q + + +K KF E + ++
Sbjct: 2020 QKQVKALEIDVE-EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREH 2078
Query: 260 KKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRR 319
++ + E++ E+ K+ + E+ +E E+L + T + EL +KE
Sbjct: 2079 ERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKE----- 2133
Query: 320 DQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQ 379
Q+ R + +++ ++ EL QAL++E ++ +E + E +LE LQ
Sbjct: 2134 -QLQRDIQERNEEIEKLEFRVRELE-QALLVED---RKHFGAVEAKPEL----SLEVQLQ 2184
Query: 380 TKFAETEEKYKHTIQILTEENIHLKQKIISKNEEI 414
+ + K K I L E+ ++++ +KNEE+
Sbjct: 2185 AERDAIDRKEKE-ITNLEEQLEQFREELENKNEEV 2218
Score = 45.4 bits (106), Expect = 1e-04
Identities = 77/340 (22%), Positives = 137/340 (40%), Gaps = 61/340 (17%)
Query: 131 EEQISELTAIIEQMNRDH--QSAQKLLSSEMDLR-----CAEMKQNFENKNRELKEAHEA 183
+ +I EL +E+M + + Q+L E ++ ++ N + RE E
Sbjct: 168 QHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMRE 227
Query: 184 ELSELENNYKAALKAEKLAAQEKLEEM-----GKEYKYLKNMFRTYQDSIYDEMEEKWSK 238
L E + K ++ ++L A E L + K T+Q ++EE+
Sbjct: 228 FLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQ----QLEEQDHL 283
Query: 239 QKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQ 298
+ KK E F + LQ+K K+ +EME ++ + N+ E I+E + +
Sbjct: 284 LEDYQKKKEDFTMQISFLQEKIKV---YEMEQDKKVENSNKEEIQEKETIIEELNTKIIE 340
Query: 299 HQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNT--- 355
+ TL+L++ T D L L Q++Q+ + + LE N+
Sbjct: 341 EEKKTLELKDKLTTA--------------DKLLGELQEQIVQKNQEIKNMKLELTNSKQK 386
Query: 356 ---------NLYYTQLELQK--------EKAIVGNLEKMLQTKF----AETEEKYKHTIQ 394
L T ELQK E IV +E+ Q K AE +E Y I
Sbjct: 387 ERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIV 446
Query: 395 ILTEENI--HLKQ--KIISKNEEICEGCSGRLASITVSKD 430
+ +E I H+ Q ++ ++++ E ++ITV++D
Sbjct: 447 QMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNED 486
Score = 45.4 bits (106), Expect = 1e-04
Identities = 67/344 (19%), Positives = 159/344 (46%), Gaps = 30/344 (8%)
Query: 79 EVINVSPGYQLVRNREQISVT---LGDEMFDRKKRW------ESEIPDKGRFSRTNIISD 129
E+++ S + + + + VT + EM +++K ES+ + R RT ++
Sbjct: 574 EIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL-RTQLLFS 632
Query: 130 LEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELE 189
EE++S+L E + +H+ + L + + KQ + E+ + + E + E
Sbjct: 633 HEEELSKLK---EDLEIEHRINIEKLKDNLGIH---YKQQIDGLQNEMSQ--KIETMQFE 684
Query: 190 NNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQ-DSIYDEMEEKWSKQKAKWKKDEK 248
+ + + + KL+++ + K+ T Q + + E+E ++K K +++
Sbjct: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744
Query: 249 FERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQH-----QSDT 303
+ + + +K K+ E + E+ ++ E+ +++ ++ + E++LK H +
Sbjct: 745 VQELQLKTELLEKQMKEKENDLQEKFAQL-EAENSILKDEKKTLEDMLKIHTPVSQEERL 803
Query: 304 LQLEELR-KTKEVPWRRD-QINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQ 361
+ L+ ++ K+K+ W ++ +I ++ L+Q + + EE+ Q N
Sbjct: 804 IFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQ--LNEEIEKQRNTFSFAEKNFEVNY 861
Query: 362 LELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQ 405
ELQ+E A + ++ L+ + E +YK ++ L EE +HL++
Sbjct: 862 QELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEE-LHLQR 904
Score = 45.4 bits (106), Expect = 1e-04
Identities = 75/369 (20%), Positives = 168/369 (45%), Gaps = 48/369 (13%)
Query: 88 QLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRD 147
Q+++ +E L +++ +++ + +K + +I DLE QI L + E + R+
Sbjct: 2277 QIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRN 2336
Query: 148 HQSAQKLLSSEMDLRCAEMKQNFENKNRELK-EAHEAELSELENNYKAALK---AEKLAA 203
+ + L+ ++ +++Q N ++ AH LSE ++ K L AEKLA
Sbjct: 2337 REEEIEQLNEVIE----KLQQELANIGQKTSMNAHS--LSEEADSLKHQLDVVIAEKLAL 2390
Query: 204 QEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFE-----RENILLQQ 258
++++E +E ++KN+ + + +E +S ++ + + EK + N+ +
Sbjct: 2391 EQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRER-ESVEKIQSIPENSVNVAIDH 2449
Query: 259 KKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLE------ELRKT 312
K + E+ E+ K E+ F++F + + + ++ LQLE +L T
Sbjct: 2450 LSKDKPELEVVLTEDALKSLEN-QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELT 2508
Query: 313 ---KEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALI----LESLNTNLYYTQ---- 361
K++ ++Q + ++++ +Q + EE A AL+ LE++ + Q
Sbjct: 2509 QCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQT 2568
Query: 362 LELQKEKAIVGNLEKM-----------LQTKFAETEEKY--KHTIQILTEENIHLKQK-I 407
+ + E+ + NL ++ L + +E E + HT IL +E + + +K +
Sbjct: 2569 ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNV 2628
Query: 408 ISKNEEICE 416
+ K +++ E
Sbjct: 2629 LEKEKKLLE 2637
Score = 44.3 bits (103), Expect = 2e-04
Identities = 54/260 (20%), Positives = 119/260 (45%), Gaps = 36/260 (13%)
Query: 88 QLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRD 147
+++R E+ TL E+ ++ + ++E+ +K + N DL+E+ ++L A + +
Sbjct: 729 EILRQEEKEKGTLEQEV--QELQLKTELLEKQMKEKEN---DLQEKFAQLEAENSILKDE 783
Query: 148 HQSAQKLLSSEMDLRCAE---MKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQ 204
++ + +L + E + ++K+++ E E+ EN LK + +
Sbjct: 784 KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENE---DLKQQCIQLN 840
Query: 205 EKLEEMGKEYKYLKNMFRT-YQD---------SIYDEMEEKWSKQKAKWKKDEKFERENI 254
E++E+ + + + F YQ+ + D++E+ +KQ+ ++K K E +
Sbjct: 841 EEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL 900
Query: 255 LLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQL-EELRKTK 313
LQ+ T K + +EDK F+ E E+ + + DT +L E+L TK
Sbjct: 901 HLQRINPTTVKMKSSVFDEDK-----------TFVAETLEMGEVVEKDTTELMEKLEVTK 949
Query: 314 EVPWRRDQINRHWHDVLQQL 333
+ ++++ D+ +QL
Sbjct: 950 R---EKLELSQRLSDLSEQL 966
Score = 40.4 bits (93), Expect = 0.003
Identities = 76/337 (22%), Positives = 153/337 (45%), Gaps = 49/337 (14%)
Query: 108 KKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMN------RDHQSAQKLLSSEMDL 161
K+ ESE P + I + Q+ E+ + M ++ S++K++ +E+
Sbjct: 3101 KREQESEKPSQELLEYN--IQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKS 3158
Query: 162 RCAEMKQNFEN----KNRELKEAHEAELSELENNYKAALKAEKLAA-QEKLEEMGKEYKY 216
A+ K E +++ LKE L + + L + LA+ Q+K E+ +
Sbjct: 3159 ELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEK 3218
Query: 217 LKNMFRTYQDSIYDEMEE-KWSKQKAKWKKDEKFERENILLQQKKKM----TKKFEMESG 271
K ++ +E+E+ K+S + K ++ + N+LL+Q+K++ +K E +
Sbjct: 3219 EKAKLGRSEERDKEELEDLKFSLESQK----QRNLQLNLLLEQQKQLLNESQQKIESQRM 3274
Query: 272 EEDKKINESCSAVFE-NFIQEKEELLKQHQSDTLQLE-----ELRKTKEVPWRRDQINRH 325
D +++E E + E E++ + S TL E +L+ + R +
Sbjct: 3275 LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS- 3333
Query: 326 WHDVLQQLLLMQVMQEELHAQALILESLNTNLYY------TQLELQKEKAIVGNLEKMLQ 379
D+L++L Q EE H++ I+E LN Y T+ +++K++ + K LQ
Sbjct: 3334 -EDLLKEL---QKQLEEKHSR--IVELLNETEKYKLDSLQTRQQMEKDRQV---HRKTLQ 3384
Query: 380 T-KFAETE-EKYKHTIQILTEENIHLKQKIISKNEEI 414
T + A TE +K H +Q E+ L++++ K +++
Sbjct: 3385 TEQEANTEGQKKMHELQSKVED---LQRQLEEKRQQV 3418
Score = 35.0 bits (79), Expect = 0.14
Identities = 43/182 (23%), Positives = 84/182 (46%), Gaps = 16/182 (8%)
Query: 98 VTLGDEMFDRKKRW--ESEIPDKGRFSRTNIISDL---EEQISELTAIIEQMNRDHQSAQ 152
+T+ +EMF + K + I D+ S + L EEQ+ ++ + + ++HQ A
Sbjct: 1546 LTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQAT 1605
Query: 153 KLLSSEMDLRCAEMKQNFENKNRELKEAHE--AELSELEN----NYKAALKAEKLAAQEK 206
+LL + +++ E E+K + A+ S ++N + + + E+L A ++
Sbjct: 1606 ELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQ 1665
Query: 207 LEEMGKEYK--YLKNMFRTYQDSIYD--EMEEKWSKQKAKWKKDEKFERENILLQQKKKM 262
L G+E L+N Q+ + E+EE+ K+K +K E E IL ++ +
Sbjct: 1666 LSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPE-ILSNERYAL 1724
Query: 263 TK 264
K
Sbjct: 1725 QK 1726
Score = 33.9 bits (76), Expect = 0.31
Identities = 62/347 (17%), Positives = 151/347 (43%), Gaps = 36/347 (10%)
Query: 106 DRKKRWESEIPDKGRFSRTNIISDLEEQIS-ELTAIIEQMNRDHQSAQKLLSSEMDLRCA 164
++ K SE DK + ++Q + +L ++EQ + +Q+ + S+ L A
Sbjct: 3219 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3278
Query: 165 EMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQ-EKLEEMGKEYKYLKNMFRT 223
++ + + +N EL+ E+E + + +L AQ + + G+ L +
Sbjct: 3279 QLSEE-QGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPS--ED 3335
Query: 224 YQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSA 283
+ ++EEK S+ + EK++ ++ LQ +++M E+D++++
Sbjct: 3336 LLKELQKQLEEKHSRIVELLNETEKYKLDS--LQTRQQM---------EKDRQVHRKTLQ 3384
Query: 284 VFENFIQEKEELLKQHQSDTLQLE-ELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEE 342
+ E ++ + + QS L+ +L + ++ ++ D + ++Q+ ++ +EE
Sbjct: 3385 TEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREE 3444
Query: 343 -LHAQALILESLN-----------TNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYK 390
++ ++ ++LN T + Q +++ E N K+++ T
Sbjct: 3445 KRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETK-ESNYAKLIEMNGGGT--GCN 3501
Query: 391 HTIQILTEENIHLKQKIISKNEEICEGCSGRLASITVSKDDSDTVQD 437
H ++++ ++ Q + SK + + + S RL T +D VQ+
Sbjct: 3502 HELEMIRQK----LQCVASKLQVLPQKASERLQFETADDEDFIWVQE 3544
Score = 30.4 bits (67), Expect = 3.4
Identities = 47/258 (18%), Positives = 110/258 (42%), Gaps = 30/258 (11%)
Query: 130 LEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELE 189
L+++I L I+E+ L S++ L + F N+ + E E + ++
Sbjct: 2528 LQKKIVNLQKIVEE------KVAAALVSQIQLEAVQEYAKFCQDNQTISS--EPERTNIQ 2579
Query: 190 NNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKF 249
N + L+ ++L + + + L++ S+ E E+ +K +K++K
Sbjct: 2580 NLNQ--LREDELGSD--ISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKL 2635
Query: 250 ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEEL 309
LL+ +K ++ E + +D ++ ++ + +F + EE ++ + L+ E +
Sbjct: 2636 LELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHS----NEESGFFNELEALRAESV 2691
Query: 310 RKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKA 369
E+ +++ + +QEEL + + SL +L + L + K
Sbjct: 2692 ATKAELASYKEKAEK--------------LQEELLVKETNMTSLQKDLSQVRDHLAEAKE 2737
Query: 370 IVGNLEKMLQTKFAETEE 387
+ LEK +T+ E+++
Sbjct: 2738 KLSILEKEDETEVQESKK 2755
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 61.2 bits (147), Expect = 2e-09
Identities = 63/345 (18%), Positives = 155/345 (44%), Gaps = 33/345 (9%)
Query: 62 KMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVT---LGDEMFDRKKRWESEIPDK 118
K+++ + + E + ++ QL+ ++Q+ V LG E+ + ++++ +
Sbjct: 226 KLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEEN 285
Query: 119 GRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELK 178
+ N+++ +E+ + Q + + +K+ E+ +R E E R+ +
Sbjct: 286 ELW---NLLNQQQEE-----KMWRQEEKIQEQEEKMCEQELKIREQE-----EKMWRQEE 332
Query: 179 EAHEAELSELENNYKAALKAEKLAAQE-KLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWS 237
+ HE E E K + EK+ QE K+ E ++ + R + I ++ EE W
Sbjct: 333 KMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW- 391
Query: 238 KQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLK 297
+Q+ K ++ E+ +E + Q+KK + ++ EE+ E E +Q++EE L+
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLR 451
Query: 298 -------------QHQSDTLQLEE--LRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEE 342
Q Q + +Q +E +++ +E WR++++ + + +Q M +E+
Sbjct: 452 EVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK 511
Query: 343 LHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEE 387
+ Q ++ + + ++++++ + E+ +Q + +E
Sbjct: 512 MWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556
Score = 57.4 bits (137), Expect = 3e-08
Identities = 67/352 (19%), Positives = 157/352 (44%), Gaps = 38/352 (10%)
Query: 84 SPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNI------ISDLEEQISEL 137
+P +L RN T+ DE K +E+ +K R + + DL+ ++
Sbjct: 201 APSLELYRN------TITDEELKEKN---AELQEKLRLVESEKSEIQLNVKDLKRKLERA 251
Query: 138 TAIIEQ---------MNRDHQSAQKLLSSEMD---LRCAEMKQNFENKNRELKEAHEAEL 185
++ Q + ++ QS L ++++ L +Q E R+ ++ E E
Sbjct: 252 QLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEE 311
Query: 186 SELENNYKAALKAEKLAAQE-KLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWK 244
E K + EK+ QE K+ E ++ + ++ ++ I ++ E+ +++ W+
Sbjct: 312 KMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWR 371
Query: 245 KDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTL 304
++EK ++ +Q++++ + E + E+++K E + ++ E++ +Q +
Sbjct: 372 QEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431
Query: 305 QLEELRKTKEVPWRRDQINRHWHDVLQ-QLLLMQVMQEELHAQALILESLNTNLYYTQLE 363
Q E++R+ +E+ +++ R + +Q + MQ +E++ Q ++ + +
Sbjct: 432 QEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491
Query: 364 LQKEKAIVGNLEKM---------LQTKFAETEEKYKHTIQILTEENIHLKQK 406
L++E+ I EKM + K E EEK + + + E+ + L Q+
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543
Score = 55.1 bits (131), Expect = 1e-07
Identities = 39/157 (24%), Positives = 84/157 (53%), Gaps = 14/157 (8%)
Query: 142 EQMNRDHQSAQKLLSSEMDLR-CAEMKQNFENKNRELKEAHEAELSEL-ENNYKAALKAE 199
EQ + + +++ E +R EM Q+ E K RE++E + E ++ E K + E
Sbjct: 417 EQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEE 476
Query: 200 KLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQK 259
K+ QE E+ ++ K LK ++ I+++ E+ W +++ W+++EK + + +Q++
Sbjct: 477 KIQEQE--EKTWRQEKLLKQ-----EEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ 529
Query: 260 KKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELL 296
++ ++ E+ ++++K+ E E +QE EE L
Sbjct: 530 EEKMREQEVRLWQQEEKMQEQ-----EVRLQELEERL 561
Score = 44.7 bits (104), Expect = 2e-04
Identities = 46/203 (22%), Positives = 92/203 (45%), Gaps = 12/203 (5%)
Query: 108 KKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMK 167
+K W E +K R I EE + I EQ + + +K+ E +R + K
Sbjct: 367 EKMWRQE--EKIREQDEKIQEQEEEMWRQEEKIREQ---EEKRQEKMWRQEKKMREQDEK 421
Query: 168 QNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDS 227
+ + +E EL E+ + + L+ + QE+ E+M ++ + ++ Q+
Sbjct: 422 IREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQR-----QEE 476
Query: 228 IYDEMEEKWSKQKAKWKKDEKF--ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVF 285
E EEK +Q+ K++EK + E + Q++K ++ +M+ EE + E
Sbjct: 477 KIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQ 536
Query: 286 ENFIQEKEELLKQHQSDTLQLEE 308
E + ++EE +++ + +LEE
Sbjct: 537 EVRLWQQEEKMQEQEVRLQELEE 559
Score = 43.5 bits (101), Expect = 4e-04
Identities = 47/210 (22%), Positives = 102/210 (48%), Gaps = 11/210 (5%)
Query: 131 EEQISELTAII-EQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSEL- 188
EE+I E I EQ + + +K+ E D + E ++ + +++E E ++
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKI--REQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 189 ENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYD--EMEEKWSKQKAKWKK- 245
K + EK+ QE EEM ++ + ++ + QD E+EEK +++ K ++
Sbjct: 410 RQEKKMREQDEKIREQE--EEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQ 467
Query: 246 DEKFER--ENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDT 303
+EK +R E I Q++K ++ ++ E+ + E E +++E++ +Q +
Sbjct: 468 EEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQ 527
Query: 304 LQLEELRKTKEVPWRRDQINRHWHDVLQQL 333
Q E++R+ + W++++ + LQ+L
Sbjct: 528 RQEEKMREQEVRLWQQEEKMQEQEVRLQEL 557
Score = 42.4 bits (98), Expect = 9e-04
Identities = 46/189 (24%), Positives = 88/189 (46%), Gaps = 31/189 (16%)
Query: 131 EEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELEN 190
EE+I EL E+M +D + +KL E E Q E K +E +E + + +++
Sbjct: 433 EEKIREL----EEMMQDQE--EKLREVE------EKMQEEEEKMQEQEEKIQRQEEKIQE 480
Query: 191 NYKAALKAEKLAAQEKL--EEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAK------ 242
+ + EKL QE+ E+ K ++ + M+ Q+ E EEK +Q+ K
Sbjct: 481 QEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE--QEEKMQEQEEKMQRQEEKMREQEV 538
Query: 243 --WKKDEKFERENILLQQKK----KMTKKFEMESG---EEDKKINESCSAVFENFIQEKE 293
W+++EK + + + LQ+ + K+ +K E+ G E + + + + + ++ +E
Sbjct: 539 RLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQE 598
Query: 294 ELLKQHQSD 302
Q Q D
Sbjct: 599 AQSLQQQQD 607
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 61.2 bits (147), Expect = 2e-09
Identities = 63/345 (18%), Positives = 155/345 (44%), Gaps = 33/345 (9%)
Query: 62 KMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVT---LGDEMFDRKKRWESEIPDK 118
K+++ + + E + ++ QL+ ++Q+ V LG E+ + ++++ +
Sbjct: 226 KLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEEN 285
Query: 119 GRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELK 178
+ N+++ +E+ + Q + + +K+ E+ +R E E R+ +
Sbjct: 286 ELW---NLLNQQQEE-----KMWRQEEKIQEQEEKMCEQELKIREQE-----EKMWRQEE 332
Query: 179 EAHEAELSELENNYKAALKAEKLAAQE-KLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWS 237
+ HE E E K + EK+ QE K+ E ++ + R + I ++ EE W
Sbjct: 333 KMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW- 391
Query: 238 KQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLK 297
+Q+ K ++ E+ +E + Q+KK + ++ EE+ E E +Q++EE L+
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLR 451
Query: 298 -------------QHQSDTLQLEE--LRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEE 342
Q Q + +Q +E +++ +E WR++++ + + +Q M +E+
Sbjct: 452 EVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK 511
Query: 343 LHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEE 387
+ Q ++ + + ++++++ + E+ +Q + +E
Sbjct: 512 MWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQE 556
Score = 56.6 bits (135), Expect = 4e-08
Identities = 54/285 (18%), Positives = 134/285 (47%), Gaps = 14/285 (4%)
Query: 136 ELTAIIEQMNRDHQSAQKLLSSEMD---LRCAEMKQNFENKNRELKEAHEAELSELENNY 192
+L +++ ++ QS L ++++ L +Q E R+ ++ E E E
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQEL 318
Query: 193 KAALKAEKLAAQE-KLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFER 251
K + EK+ QE K+ E ++ + ++ ++ I ++ E+ +++ W+++EK
Sbjct: 319 KIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIRE 378
Query: 252 ENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRK 311
++ +Q++++ + E + E+++K E + ++ E++ +Q + Q E++R+
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 312 TKEVPWRRDQINRHWHDVLQ-QLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAI 370
+E+ +++ R + +Q + MQ +E++ Q ++ + + L++E+ I
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKI 498
Query: 371 VGNLEKM---------LQTKFAETEEKYKHTIQILTEENIHLKQK 406
EKM + K E EEK + + + E+ + L Q+
Sbjct: 499 WEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543
Score = 55.1 bits (131), Expect = 1e-07
Identities = 39/157 (24%), Positives = 84/157 (53%), Gaps = 14/157 (8%)
Query: 142 EQMNRDHQSAQKLLSSEMDLR-CAEMKQNFENKNRELKEAHEAELSEL-ENNYKAALKAE 199
EQ + + +++ E +R EM Q+ E K RE++E + E ++ E K + E
Sbjct: 417 EQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEE 476
Query: 200 KLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQK 259
K+ QE E+ ++ K LK ++ I+++ E+ W +++ W+++EK + + +Q++
Sbjct: 477 KIQEQE--EKTWRQEKLLKQ-----EEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ 529
Query: 260 KKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELL 296
++ ++ E+ ++++K+ E E +QE EE L
Sbjct: 530 EEKMREQEVRLWQQEEKMQEQ-----EVRLQELEERL 561
Score = 44.7 bits (104), Expect = 2e-04
Identities = 46/203 (22%), Positives = 92/203 (45%), Gaps = 12/203 (5%)
Query: 108 KKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMK 167
+K W E +K R I EE + I EQ + + +K+ E +R + K
Sbjct: 367 EKMWRQE--EKIREQDEKIQEQEEEMWRQEEKIREQ---EEKRQEKMWRQEKKMREQDEK 421
Query: 168 QNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDS 227
+ + +E EL E+ + + L+ + QE+ E+M ++ + ++ Q+
Sbjct: 422 IREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQR-----QEE 476
Query: 228 IYDEMEEKWSKQKAKWKKDEKF--ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVF 285
E EEK +Q+ K++EK + E + Q++K ++ +M+ EE + E
Sbjct: 477 KIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQ 536
Query: 286 ENFIQEKEELLKQHQSDTLQLEE 308
E + ++EE +++ + +LEE
Sbjct: 537 EVRLWQQEEKMQEQEVRLQELEE 559
Score = 43.5 bits (101), Expect = 4e-04
Identities = 47/210 (22%), Positives = 102/210 (48%), Gaps = 11/210 (5%)
Query: 131 EEQISELTAII-EQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSEL- 188
EE+I E I EQ + + +K+ E D + E ++ + +++E E ++
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKI--REQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 189 ENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYD--EMEEKWSKQKAKWKK- 245
K + EK+ QE EEM ++ + ++ + QD E+EEK +++ K ++
Sbjct: 410 RQEKKMREQDEKIREQE--EEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQ 467
Query: 246 DEKFER--ENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDT 303
+EK +R E I Q++K ++ ++ E+ + E E +++E++ +Q +
Sbjct: 468 EEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQ 527
Query: 304 LQLEELRKTKEVPWRRDQINRHWHDVLQQL 333
Q E++R+ + W++++ + LQ+L
Sbjct: 528 RQEEKMREQEVRLWQQEEKMQEQEVRLQEL 557
Score = 42.4 bits (98), Expect = 9e-04
Identities = 46/189 (24%), Positives = 88/189 (46%), Gaps = 31/189 (16%)
Query: 131 EEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELEN 190
EE+I EL E+M +D + +KL E E Q E K +E +E + + +++
Sbjct: 433 EEKIREL----EEMMQDQE--EKLREVE------EKMQEEEEKMQEQEEKIQRQEEKIQE 480
Query: 191 NYKAALKAEKLAAQEKL--EEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAK------ 242
+ + EKL QE+ E+ K ++ + M+ Q+ E EEK +Q+ K
Sbjct: 481 QEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE--QEEKMQEQEEKMQRQEEKMREQEV 538
Query: 243 --WKKDEKFERENILLQQKK----KMTKKFEMESG---EEDKKINESCSAVFENFIQEKE 293
W+++EK + + + LQ+ + K+ +K E+ G E + + + + + ++ +E
Sbjct: 539 RLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQE 598
Query: 294 ELLKQHQSD 302
Q Q D
Sbjct: 599 AQSLQQQQD 607
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 61.2 bits (147), Expect = 2e-09
Identities = 72/355 (20%), Positives = 155/355 (43%), Gaps = 49/355 (13%)
Query: 99 TLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSE 158
TL +EM+ R E E+ ++ + I E+ + + EQ + + +K+ E
Sbjct: 231 TLQEEMW----RQEEELREQEK----KIRKQEEKMWRQEERLREQEGKMREQEEKMRRQE 282
Query: 159 MDLRCAEMKQNFENKN-RELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYL 217
LR E + + K RE K+ E E E K + EK+ QE E+M ++ + L
Sbjct: 283 KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQE--EKMWRQEERL 340
Query: 218 ---KNMFRTYQDSIYDEMEEKWS-------------KQKAKWKKDEKFERENILLQQKKK 261
+ R + + D+ E W +Q+ W+++EK + E + +++KK
Sbjct: 341 WEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKK 400
Query: 262 MTKKFEMESGEEDK-------------------KINESCSAVFE-NFIQEKEELLKQHQS 301
M ++ E +E+K ++ E ++E +QE+EE + + +
Sbjct: 401 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 460
Query: 302 DTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQ 361
EE+ ++ WR++++ + +Q M+ ++++ Q + + L +
Sbjct: 461 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE 520
Query: 362 LELQKEKAIVGNLEKMLQTKFAETEEK--YKHTIQILTEENIHLKQKIISKNEEI 414
++++K + EKM + K + +EK + ++ EE + ++K + + EE+
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM 575
Score = 58.5 bits (140), Expect = 1e-08
Identities = 71/375 (18%), Positives = 165/375 (44%), Gaps = 39/375 (10%)
Query: 102 DEMFDRKKRWESE--IPDKGRF-SRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSE 158
+ M +++K WE E + ++ R R + + EE + E E+M + ++ + E
Sbjct: 373 ERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQE---EKMQKQEENMWEQEEKE 429
Query: 159 -MDLRCAEMKQNF--ENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYK 215
R E K+ + K +E +E + ++ + + + +K+ QEK+ E +
Sbjct: 430 WQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW 489
Query: 216 YLKNMFRTYQDSIYDEMEEKWSK-------------QKAKWKKDEKF-------ERENIL 255
+ R + ++D+ E W + QK W+++EK E+E
Sbjct: 490 EQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKT 549
Query: 256 LQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEE-LRKTKE 314
Q++KM ++ M E+ + E E +QE+EE +++ + + EE +++ +E
Sbjct: 550 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEE 609
Query: 315 VPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNL 374
W +++ + W ++ MQ +E + Q ++ ++ + ++++++ +
Sbjct: 610 KMWEQEE--KMWEQ--EEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQ 665
Query: 375 EKMLQ---TKFAETEEKYKHTIQIL--TEENIHLKQKIISKNEEICEGCSGRLASITVSK 429
E+ +Q K E EEK + + + EE + +++ + EE G ++ +
Sbjct: 666 EEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMR 725
Query: 430 DDSDTVQDGSKKGQE 444
+ + ++D +K QE
Sbjct: 726 EKEERIRDQKEKMQE 740
Score = 55.1 bits (131), Expect = 1e-07
Identities = 66/360 (18%), Positives = 155/360 (43%), Gaps = 20/360 (5%)
Query: 62 KMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRF 121
KM+ R E K E + +R +E+ ++M++++++ + ++ +
Sbjct: 277 KMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQ--EEKMW 334
Query: 122 SRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAH 181
+ + + E+Q+ E EQ RD + +++ + LR E + + K E +E
Sbjct: 335 RQEERLWEQEKQMREQ----EQKMRDQE--ERMWEQDERLREKEERMREQEKMWEQEEKM 388
Query: 182 EAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKA 241
+ E E K + E + QE+ + +E + + Q + ++ E+ W ++K
Sbjct: 389 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 448
Query: 242 K------WKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEEL 295
+ W+++EK + + Q+KKM ++ +M E+ E E + ++EE
Sbjct: 449 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508
Query: 296 LKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNT 355
+ + + EE + ++ W++++ R +Q +E++ + + E
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK 568
Query: 356 NLYYTQLELQKEKAIVGNLEKM--LQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEE 413
++ ++E+ + EKM + K E EEK + + + E+ ++K+ + EE
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQ----EEKMWEQEEE 624
Score = 53.1 bits (126), Expect = 5e-07
Identities = 59/287 (20%), Positives = 137/287 (47%), Gaps = 31/287 (10%)
Query: 136 ELTAIIEQMNRDHQSAQKL---LSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNY 192
EL + ++ H+ A + L+ E D E+ +N N ELK+ + +EL+
Sbjct: 142 ELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTIT-NEELKKKN----AELQEKL 196
Query: 193 KAALKAEKLAAQEKLEEMGKEYKYLKNMF-----RTYQDSIYDEMEEKWSKQKAKWKKDE 247
+ A ++EK Q ++E+ ++ + K + T Q+ ++ + EE ++K K++E
Sbjct: 197 RLA-ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 255
Query: 248 KFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLE 307
K R+ L++++ ++ E + ++K++ E E ++E+E+ L++ + Q E
Sbjct: 256 KMWRQEERLREQEGKMREQEEKMRRQEKRLREQ-----EKELREQEKELREQKKLREQEE 310
Query: 308 ELRKTKEVPWRRDQINRHWHDVL-QQLLLMQVMQEELHAQALILESLNTNLYYTQLELQK 366
++++ +E W +++ R + + +Q + ++++ Q + ++ L++
Sbjct: 311 QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLRE 370
Query: 367 EKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEE 413
++ + EKM E EEK + EE I ++K + + EE
Sbjct: 371 KEERMREQEKMW-----EQEEKMQE------EERIREREKKMREEEE 406
Score = 48.5 bits (114), Expect = 1e-05
Identities = 39/197 (19%), Positives = 95/197 (48%), Gaps = 20/197 (10%)
Query: 88 QLVRNREQISVTLGDEMFDRK-KRWESEIPDKGRFSRTNIISDLEEQISELTAII-EQMN 145
+++R +E+ ++M +++ K WE E + + EE++ E + EQ
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQE----------EKMQEQEEKMWEQEEKMWEQEE 623
Query: 146 RDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQE 205
D Q+ + E + + E ++ + +++E E ++ E E + + EK+ QE
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEE-KMREQEEKMQG--QEEKMREQE 680
Query: 206 -KLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTK 264
K++ ++ + + R ++ ++ + E+ W +++ W ++E E+E + QK+KM +
Sbjct: 681 EKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740
Query: 265 KFEMESGEEDKKINESC 281
+ E +++ +E C
Sbjct: 741 RLP----EHEERCSEPC 753
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 60.8 bits (146), Expect = 2e-09
Identities = 77/339 (22%), Positives = 141/339 (41%), Gaps = 51/339 (15%)
Query: 117 DKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRE 176
+K R ++ EE++++ + Q R A ++ + D A+ + F K
Sbjct: 1585 EKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQD-DREMAQAEGKFAQKEET 1643
Query: 177 LKEAHEAELSELEN----NYKAALKAEKLAAQE-KLEEMGKEYKYLKNMFRT-------- 223
L + E E E K A K EK+A +E KL + G + +KN+
Sbjct: 1644 LAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQR 1703
Query: 224 ------YQDSIYDEMEE-KWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKK 276
+ + E+EE +W ++ WK++E + E L+++KKK+ ++ E + + +K
Sbjct: 1704 EQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKL 1763
Query: 277 INESCSAVFEN--FIQEKEELLKQHQSDTLQLEELRKTK----EVPWRRDQINRHWHDVL 330
E E IQEKE+L + + + E L + + E + Q W + +
Sbjct: 1764 SEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSM 1823
Query: 331 QQLLLMQVM----------QEELHAQALILESLNTNLYYTQLEL---QKEKAIVGNLEKM 377
++L +++ ++ L + L NL Y + L +K+ V N M
Sbjct: 1824 EELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGM 1883
Query: 378 LQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEICE 416
A+ EEK LT+E K+ +I K E++ E
Sbjct: 1884 FNKILAQVEEK-------LTQE----KETVIKKKEKLAE 1911
Score = 50.8 bits (120), Expect = 2e-06
Identities = 48/205 (23%), Positives = 93/205 (45%), Gaps = 43/205 (20%)
Query: 108 KKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMK 167
+KR E++ DK + ++ + ++E + E + + +S L + L E +
Sbjct: 2198 RKRKEAKRGDKPKEKFSSQVDEVESE--------EHFSEEMESLLDELEKQESLSSEEEE 2249
Query: 168 QNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDS 227
+ E + RE +E E E + K EE G+E +
Sbjct: 2250 EREEEEEREEEEVREEE------------------EERKEEEEGEEKQV----------- 2280
Query: 228 IYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFEN 287
E EE+ K+K K KK E+ + + + ++K+++ + E ES ++++ ESCS E
Sbjct: 2281 ---EKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCS--LEE 2335
Query: 288 FIQEKEELLKQHQSDTLQLEELRKT 312
+ ++E+LK+ + LQ E+ RK+
Sbjct: 2336 EVDREKEILKKEKQFKLQ-EQRRKS 2359
Score = 42.4 bits (98), Expect = 9e-04
Identities = 68/332 (20%), Positives = 141/332 (42%), Gaps = 46/332 (13%)
Query: 95 QISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDH----QS 150
++ T G +F + +R ++ K + +S +++++ ++++ RD Q
Sbjct: 2035 KLEFTRGQRIFVQGQRKLAKASRK-LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQE 2093
Query: 151 AQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAEL-SELENNYKAALKAEKLAAQEKLEE 209
K+ + L E + + E ++KE +E SEL + K + ++ A +
Sbjct: 2094 EIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRM 2153
Query: 210 MGKEYKYLKN---MFRTYQDSIYDEMEE--------------KWSKQKAKWKKD---EKF 249
+ KE K + + R + + I D+ EE +W K+K + D EKF
Sbjct: 2154 INKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKF 2213
Query: 250 -------ERENILLQQKKKMTKKFEME---SGEEDKKINESCSAVFENFIQEKEELLKQH 299
E E ++ + + + E + S EE+++ E E +E+EE ++
Sbjct: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273
Query: 300 QSDTLQL---EELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTN 356
+ + Q+ EE +K K+ +++++ +V ++ ++M EE ++L E
Sbjct: 2274 EGEEKQVEKEEEEKKKKKKEKKKEEVQEK-EEVFEE--KEEIMSEE-ETESLSDEEEEEE 2329
Query: 357 LYYTQLELQKEKAIVGNLEKMLQTKFAETEEK 388
+ E+ +EK I L+K Q K E K
Sbjct: 2330 SCSLEEEVDREKEI---LKKEKQFKLQEQRRK 2358
Score = 38.9 bits (89), Expect = 0.010
Identities = 63/341 (18%), Positives = 142/341 (41%), Gaps = 44/341 (12%)
Query: 77 FYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSR--TNIISDLEEQI 134
F E NV+ G ++ + E+ + + + + E ++ G+ R T D+ E++
Sbjct: 1375 FLEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKV---GKIKREMTKEERDMSEEV 1431
Query: 135 SELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKA 194
E+ + E++ + KL+ E + K+ ++ E K+ H E + +K
Sbjct: 1432 EEMATLEEKVVKQEG---KLVMIERTPSWQDWKKAWD----EWKQVH-GETRKSWKAWKE 1483
Query: 195 ALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENI 254
+ L +EKL + G++ + M + + ++E ++ W + K+++++ E
Sbjct: 1484 EWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE-- 1541
Query: 255 LLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQH----QSDTLQLEELR 310
++ + ++ E E+++++ E + IQE+ + + H +++ + +E R
Sbjct: 1542 ---EEVTLEEEVSREGEEKEQQVTEE-----QRHIQEEHKWARIHRKRARAEKKRAQEER 1593
Query: 311 KTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLE---LQKE 367
K + + Q R Q+ QEE ++ + Q E QKE
Sbjct: 1594 KLAQEEEKLAQEER------------QLAQEERKLAQAYVKITQDDREMAQAEGKFAQKE 1641
Query: 368 KAIVGNLEKMLQ--TKFAETEEKYKHTIQILTEENIHLKQK 406
+ + EK+ Q K A+ +K + + E L +K
Sbjct: 1642 ETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKK 1682
Score = 38.5 bits (88), Expect = 0.012
Identities = 45/201 (22%), Positives = 90/201 (44%), Gaps = 16/201 (7%)
Query: 126 IISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKE------ 179
+I + E+ + E+ R + ++L+ +M L A+ ++ + N EL +
Sbjct: 1777 LIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKL--AQKRERWINSMEELTKNKMILY 1834
Query: 180 -----AHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEE 234
A E + E A K L +E+L K+ +KN + + I ++EE
Sbjct: 1835 QKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMF-NKILAQVEE 1893
Query: 235 KWSKQKAKW-KKDEKF-ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEK 292
K +++K KK EK E E L+Q + + KK E + E+ K E + ++ +
Sbjct: 1894 KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGE 1953
Query: 293 EELLKQHQSDTLQLEELRKTK 313
++ K+ ++ L+++ L + K
Sbjct: 1954 LDIAKEEKALNLEMKRLAEEK 1974
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 60.5 bits (145), Expect = 3e-09
Identities = 76/347 (21%), Positives = 155/347 (44%), Gaps = 65/347 (18%)
Query: 122 SRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAH 181
S+ ++ + E+QI +L I+ +QKL + +MDL + ++ E+ + +
Sbjct: 579 SKVELLREKEDQIKKLQEYID--------SQKLENIKMDLSYS--LESIEDPKQMKQTLF 628
Query: 182 EAELSELENNYKAA-LKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQK 240
+AE L+ ++A L++E L +EK++E+ YK ++N + YQ S+ +
Sbjct: 629 DAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQ-----------SQLE 677
Query: 241 AKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQ 300
AK K E+E L ++TK + G+ K + C+ E I + ++ L +
Sbjct: 678 AKKKMQVDLEKE--LQSAFNEITKLTSLIDGKVPKDL--LCNLELEGKITDLQKELNKEV 733
Query: 301 SDTLQLEE----LRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTN 356
+ L E L + K +P +++ + D ++L ++ +++L ++
Sbjct: 734 EENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEV--------- 784
Query: 357 LYYTQLELQKEKAIVGNLEKMLQTK--FAETEEKYKHTIQ-----------------ILT 397
+ KE + G LE++ +TK A T+ YK T Q ++
Sbjct: 785 -------VHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVL 837
Query: 398 EENIHLKQKIISKNEEICEGCSGRLASITVSKDDSDTVQDGSKKGQE 444
EEN + Q+I++ ++E + S A T + +Q+ +++ QE
Sbjct: 838 EENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Score = 48.5 bits (114), Expect = 1e-05
Identities = 66/319 (20%), Positives = 148/319 (46%), Gaps = 15/319 (4%)
Query: 127 ISDLEEQISELTAIIEQMNRDHQSA-QKLLSSEMDLRCAEMKQNFENKN--RELKEAHEA 183
+S+ E +IS + +E +N Q+ Q++ E ++ + E N ++ KE +A
Sbjct: 1500 LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA 1559
Query: 184 ELSELENNYKAALKAEKLA--AQEKLEEMGKEYKYLKNMFRTYQ---DSIYDEMEEKWSK 238
+ S L++ L+ +QE+++ M KE + +K + Q D + + +E +K
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK 1619
Query: 239 QKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKIN-ESCSAVFENFIQEKEELLK 297
K +K+ +F + + + ++KM + ++ E +K+N E+ Q E L+
Sbjct: 1620 MKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE 1679
Query: 298 QHQSDTLQLEELRKTKE-VPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTN 356
+ +S T + ++LR +E + RDQ+ + + + + L QEEL + L+
Sbjct: 1680 EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL---EKQEELKIVHMHLKEHQET 1736
Query: 357 LYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLK--QKIISKNEEI 414
+ + + ++ + N++K L+ + + + L ++HLK Q+ I K I
Sbjct: 1737 IDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGI 1796
Query: 415 CEGCSGRLASITVSKDDSD 433
+ +L+++ ++S+
Sbjct: 1797 VSEKTDKLSNMQKDLENSN 1815
Score = 42.0 bits (97), Expect = 0.001
Identities = 57/298 (19%), Positives = 129/298 (43%), Gaps = 42/298 (14%)
Query: 128 SDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSE 187
+++ EQ ++ ++I++ N Q + +++ + L+ ++K+N E + ++ EL
Sbjct: 1036 NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLK-TDLKENIE-----MTIENQEELRL 1089
Query: 188 LENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDE 247
L + K K +++ AQEK + KE + + R + +E
Sbjct: 1090 LGDELK---KQQEIVAQEKNHAIKKEGELSRTCDRLAE-------------------VEE 1127
Query: 248 KFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQL- 306
K + ++ LQ+K++ + E E KKINE + +N ++ KE L+ +++ L+L
Sbjct: 1128 KLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIEN--LKNELKNKELTLEHMETERLELA 1185
Query: 307 ----EELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQL 362
E + K + R + + ++ E+ A L L +
Sbjct: 1186 QKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGL---QTKEELKIAHI 1242
Query: 363 ELQKEKAIVGNLEKMLQTKFAE---TEEKYKHTIQILTE-ENIHLKQKIISKNEEICE 416
L++ + + L + + K A+ T++ K ++ E +H +Q+++ +E+ E
Sbjct: 1243 HLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSE 1300
Score = 42.0 bits (97), Expect = 0.001
Identities = 71/323 (21%), Positives = 134/323 (41%), Gaps = 61/323 (18%)
Query: 123 RTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHE 182
R I DLE+Q E I+ ++HQ L + +E N ++L+ +++
Sbjct: 1710 RETITRDLEKQ--EELKIVHMHLKEHQETIDKLRGIV----SEKTNEISNMQKDLEHSND 1763
Query: 183 AELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAK 242
A LKA+ L Q EE+ + +LK T D + + EK K +
Sbjct: 1764 A------------LKAQDLKIQ---EELRIAHMHLKEQQETI-DKLRGIVSEKTDK-LSN 1806
Query: 243 WKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSD 302
+KD E N LQ+K + K E + K +NE+ + + E E+L KQ +
Sbjct: 1807 MQKD--LENSNAKLQEKIQELKANEHQLITLKKDVNET-----QKKVSEMEQLKKQIKDQ 1859
Query: 303 TLQL---------------EELRKTKEVPWRRDQINR----------HWHDVLQQLLLMQ 337
+L L E L + K V RD + R + LQ+
Sbjct: 1860 SLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARD 1919
Query: 338 V-MQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEK----YKHT 392
+ +Q+EL ++ + + + ++ ++ + +++K L E ++K K
Sbjct: 1920 LEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKE 1979
Query: 393 IQIL-TEENIHLKQKIISKNEEI 414
+Q+L +E++++ K I++ E++
Sbjct: 1980 LQLLRVKEDVNMSHKKINEMEQL 2002
Score = 40.8 bits (94), Expect = 0.003
Identities = 78/330 (23%), Positives = 135/330 (40%), Gaps = 32/330 (9%)
Query: 127 ISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELS 186
++ L L EQ+ + + + L + DL E + K++E++ H E+S
Sbjct: 500 LNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIH--EIS 557
Query: 187 ELENNYKAA------LKAEKLAAQEKLEEMGKEYKYLKNMF--RTYQDSIYDEMEEKWSK 238
L+N K A L+ E + E L E + K L+ + ++ D S
Sbjct: 558 NLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESI 617
Query: 239 QKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAV--FENFIQEKEELL 296
+ K K F+ E + L K++ + E+ E +K+ E + EN IQ + L
Sbjct: 618 EDPKQMKQTLFDAETVALDAKRE-SAFLRSENLELKEKMKELATTYKQMENDIQLYQSQL 676
Query: 297 KQHQSDTLQLE-ELRKT-KEVPWRRDQIN-RHWHDVLQQLLL---MQVMQEELHAQALIL 350
+ + + LE EL+ E+ I+ + D+L L L + +Q+EL+ +
Sbjct: 677 EAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN 736
Query: 351 ESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISK 410
E+L + EL+ + V L K +Q K E + I+T E L +++ K
Sbjct: 737 EALREEVILLS-ELKSLPSEVERLRKEIQDKSEE--------LHIITSEKDKLFSEVVHK 787
Query: 411 NEEICEGCSGRLASITVSKDDSDTVQDGSK 440
+ G L I +KDD T Q K
Sbjct: 788 ESRV----QGLLEEIGKTKDDLATTQSNYK 813
Score = 37.7 bits (86), Expect = 0.021
Identities = 64/341 (18%), Positives = 138/341 (40%), Gaps = 48/341 (14%)
Query: 125 NIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRE-LKEAHEA 183
+ I ++E+Q EL I+ + +D + +LR ++ QN + E LK+ E+
Sbjct: 2197 DFIDEVEKQ-KELLIKIQHLQQDCDVPSR------ELRDLKLNQNMDLHIEEILKDFSES 2249
Query: 184 ELSELENNYKAALKAEKLAAQEKLEEMGKEY--KYLKNMFRTYQDSIYD----------- 230
E ++ ++ L K Q E + + + LKN + D I
Sbjct: 2250 EFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIA 2309
Query: 231 ------EMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAV 284
E EE+ + +W++D K +E K T K + SG + +N +
Sbjct: 2310 IMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQ---VNPT---- 2362
Query: 285 FENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELH 344
Q+ + ++ L E++R+ + + ++ + + + MQ+EL
Sbjct: 2363 ----TQDNKNPHVTSRATQLTTEKIRELE------NSLHEAKESAMHKESKIIKMQKELE 2412
Query: 345 AQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLK 404
I+ L ++ + L+K K + ++LQ K A + YK I+ L + + +
Sbjct: 2413 VTNDIIAKLQAKVHESNKCLEKTKETI----QVLQDKVALGAKPYKEEIEDLKMKLVKID 2468
Query: 405 QKIISKNEEICEGCSGRLASITVSKDDSDTVQDGSKKGQES 445
+ + +E + S A++ K+ +++ ++ Q++
Sbjct: 2469 LEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQA 2509
Score = 35.0 bits (79), Expect = 0.14
Identities = 60/292 (20%), Positives = 130/292 (44%), Gaps = 38/292 (13%)
Query: 124 TNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEA 183
T++ +L +++ E A+ E++ S K L SE++ +++ ++K+ EL
Sbjct: 723 TDLQKELNKEVEENEALREEVIL--LSELKSLPSEVE----RLRKEIQDKSEEL----HI 772
Query: 184 ELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKW 243
SE + + + E Q LEE+GK K+ T Q + Y ++++ K
Sbjct: 773 ITSEKDKLFSEVVHKES-RVQGLLEEIGKT----KDDLATTQSN-YKSTDQEFQNFKTLH 826
Query: 244 KKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDT 303
E ++ ++L++ ++M ++ + +E +K + S A+ + +EL ++ +
Sbjct: 827 MDFE--QKYKMVLEENERMNQEI-VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQ 883
Query: 304 LQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLE 363
+L E+ + KE RD +Q ++ E + LI E L L +
Sbjct: 884 ERLNEMEQLKEQLENRDS-------------TLQTVERE---KTLITEKLQQTLEEVK-T 926
Query: 364 LQKEKAIVGNLEKMLQTKFAETEEKYKHTI--QILTEENIHLKQKIISKNEE 413
L +EK + L++ LQ + + + T+ I T+E + + + +++E
Sbjct: 927 LTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 57.8 bits (138), Expect = 2e-08
Identities = 66/298 (22%), Positives = 134/298 (44%), Gaps = 29/298 (9%)
Query: 126 IISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQ--NFENKNRELKEAHEA 183
++ + Q L++ I Q+ + S Q+ E + R KQ +++ + K+ +
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 184 ELSELENNYKAALKAEK--LAAQEKLEEMGKEYKYL---KNMFRTYQDSIYDEMEEKWSK 238
+L +E+ +A K K A ++LEE Y L KN + D + +++ +
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442
Query: 239 QKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINE------SCSAVFENFIQEK 292
KK +KF++ LL ++K ++ ++ E + + E S + E ++ K
Sbjct: 1443 ASNLEKKQKKFDQ---LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAK 1499
Query: 293 EELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILES 352
EE +Q++ +E+L +K D + ++ H++ + ++ EE+ Q LE
Sbjct: 1500 EEFERQNKQLRADMEDLMSSK------DDVGKNVHELEKSKRALEQQVEEMRTQ---LEE 1550
Query: 353 LNTNLYYTQ---LELQ-KEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQK 406
L L T+ L L+ +A+ E+ LQT+ + EEK + I+ + E L+ +
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDE 1608
Score = 55.8 bits (133), Expect = 8e-08
Identities = 81/412 (19%), Positives = 176/412 (42%), Gaps = 66/412 (16%)
Query: 64 KIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSR 123
K+ R E + E + +RN++++ ++ +E ++++ E+ +K +
Sbjct: 1002 KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL-EKAKRKL 1060
Query: 124 TNIISDLEEQISELTAIIEQMNRD--------------------HQSAQKLLSSEMDLRC 163
+DL++QI+EL A I+++ H++ + E+ +
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 164 AEMKQNFEN----------KNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKE 213
AE++++FE+ + R+L E EA +ELE+ ++L + + +E+ +
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE-QEVAEL 1179
Query: 214 YKYLKNMFRTYQDSIYD-------------EMEEKWSKQKAKWKKDEK-FERENILLQQK 259
K L+ + ++ I D E E+ + KA +K+++ E +N L +
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Query: 260 KKMTKKFEMESGEEDKKINESCSAVFENF---------IQEKEELLKQHQSDTLQLEELR 310
K+ ++ + ES + KK++ + + EK L+ + L E
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299
Query: 311 KTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAI 370
+ K + + +D + Q LL + +++L+ + I L Q + ++E+
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRI-RQLEEEKNSLQEQQEEEEEA 1358
Query: 371 VGNLEKM---LQTKFAETEEKYKH---TIQILTEENIHLKQKIISKNEEICE 416
NLEK LQ++ A+T++K TI+ L E K+K++ E + +
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE----AKKKLLKDAEALSQ 1406
Score = 43.5 bits (101), Expect = 4e-04
Identities = 45/196 (22%), Positives = 87/196 (44%), Gaps = 22/196 (11%)
Query: 91 RNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNR---- 146
R+ EQ L DE+ + + + +K R I+ LEE++ E + +E +N
Sbjct: 1704 RHAEQERDELADEITNSASGKSALLDEKRRLEAR--IAQLEEELEEEQSNMELLNDRFRK 1761
Query: 147 -----DHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYK-------A 194
D +A+ + +Q E +N+ELK A+L ELE K +
Sbjct: 1762 TTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK----AKLQELEGAVKSKFKATIS 1817
Query: 195 ALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENI 254
AL+A+ +E+LE+ KE + R + + + + +++ + E+ E+ N
Sbjct: 1818 ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANA 1877
Query: 255 LLQQKKKMTKKFEMES 270
++Q K+ ++ E E+
Sbjct: 1878 RMKQLKRQLEEAEEEA 1893
Score = 36.6 bits (83), Expect = 0.047
Identities = 64/296 (21%), Positives = 124/296 (41%), Gaps = 45/296 (15%)
Query: 121 FSRTNIISDLEEQ----ISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRE 176
F R +++ LEE+ I+++ + + R + + + + L ++ Q N
Sbjct: 769 FFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQR--NCAAY 826
Query: 177 LKEAHEAELSELENNYKAALKAEKLAAQEKLEE--MGKEYKYLKNMFRTYQDSIYDEMEE 234
LK H ++ K + L + EE K+ + LK + Q + E+EE
Sbjct: 827 LKLRHWQW-------WRVFTKVKPLLQVTRQEEELQAKDEELLK--VKEKQTKVEGELEE 877
Query: 235 KWSKQKAKWKKDEKFERENILLQQKKKMTKKF----EMESGEEDKKIN-ESCSAVFENFI 289
K + + E +NIL +Q + T+ F EM + KK E E+ +
Sbjct: 878 MERKHQ------QLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRV 931
Query: 290 QEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQE----ELHA 345
+E+EE ++ LQ E+ + + +Q++ Q+L L +V E ++
Sbjct: 932 EEEEE-----RNQILQNEKKKMQAHIQDLEEQLDEE-EGARQKLQLEKVTAEAKIKKMEE 985
Query: 346 QALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENI 401
+ L+LE N+ KEK ++ + ++ AE EEK K+ +I ++ +
Sbjct: 986 EILLLEDQNSKFI-------KEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEV 1034
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 57.8 bits (138), Expect = 2e-08
Identities = 80/373 (21%), Positives = 159/373 (42%), Gaps = 44/373 (11%)
Query: 72 ETNKSFYEVINVSPG-YQLVRNREQISVTLGDEMFDRKKRWES----------EIPDKGR 120
ET + +E + + +R+R + T G+E+ ++K++ E K
Sbjct: 368 ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTE 427
Query: 121 FSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEA 180
+R + ++++EQI + E+ + S Q+ LS MK++ E + +L++
Sbjct: 428 EARRKLKAEMDEQIKTIEKTSEE---ERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKL 484
Query: 181 HEAELSELENNYKAALKAEKLAAQEK----LEEMGKEYKYLKNMFRTYQDSIYDEME--- 233
HE EL+ E L+ + QE+ LE+ EY + + +E+E
Sbjct: 485 HEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQK 544
Query: 234 -----EKWSK-----QKAKWKKDEKFERENIL---LQQKKKMTKKFEMESGEEDKKINES 280
E +K Q+A+ + E E+ L LQ+ K +K + E K N+
Sbjct: 545 KAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKE 604
Query: 281 CSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQ 340
+ + E E E L +HQ D L E+L+ K+ + R + ++ LL
Sbjct: 605 ITVMVEKHKTELESL--KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLL---KD 659
Query: 341 EELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEEN 400
+E+ QA I E L ++ + +++ L ++L+ + K + + +L ++
Sbjct: 660 KEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR-----HKLEEELSVLKDQT 714
Query: 401 IHLKQKIISKNEE 413
+KQ++ +K +E
Sbjct: 715 DKMKQELEAKMDE 727
Score = 53.9 bits (128), Expect = 3e-07
Identities = 64/332 (19%), Positives = 141/332 (42%), Gaps = 27/332 (8%)
Query: 100 LGDEMFDRKKRWESEIP--DKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSS 157
LG+E +R K E +I + +S + ++++ + ++ + ++ + L S
Sbjct: 1572 LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631
Query: 158 EMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYL 217
E + AE+K+ E K +K+ +++ E E YK ++ KL+E +E L
Sbjct: 1632 ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHIL 1691
Query: 218 KNMFRTYQDS---------------IYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKM 262
+ ++ + S Y E EE S+ + +EK L +K+K+
Sbjct: 1692 EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL 1751
Query: 263 TKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQI 322
++ E E+ S+ FE Q +E L+K ++ Q E+ + ++
Sbjct: 1752 LQRVGQEK-------EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEK 1804
Query: 323 NRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKF 382
N+ + ++ Q + + + + A+ LE++ ++ T E + I+ K L +
Sbjct: 1805 NKKYSLIVAQHVEKEGGKNNIQAKQ-NLENVFDDVQKTLQEKELTCQILEQKIKELDSCL 1863
Query: 383 AETEEKYKHTIQILTE--ENIHLKQKIISKNE 412
+E ++ ++ LT E + Q++ +N+
Sbjct: 1864 VRQKEVHRVEMEELTSKYEKLQALQQMDGRNK 1895
Score = 53.1 bits (126), Expect = 5e-07
Identities = 66/292 (22%), Positives = 130/292 (44%), Gaps = 43/292 (14%)
Query: 130 LEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSE-- 187
LE++I EL + + + H+ + L+S+ + A + + NK EL E + E S+
Sbjct: 1852 LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSH 1911
Query: 188 -----LENNYKAA---LKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQ 239
L +N +A L+ + A+ + +++GKE L+ R + E+E K+
Sbjct: 1912 LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL--KK 1969
Query: 240 KAKWKKDEKFERENILLQQK-----KKMTKKFEMESGEEDKKINESCSAVFENFIQEKEE 294
+ +++EK ++E L+ K K++ ++F + ++++++ + + + E
Sbjct: 1970 EYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE 2029
Query: 295 LLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLN 354
LL+ HQ +T QL L+K E + + + ++L +EE+ A+ L+
Sbjct: 2030 LLESHQEETNQL--LKKIAEKDDDLKRTAKRYEEIL------DAREEEMTAKVRDLQ--- 2078
Query: 355 TNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQK 406
TQLE L+K Q K + E + I+ E L QK
Sbjct: 2079 -----TQLE---------ELQKKYQQKLEQEENPGNDNVTIM-ELQTQLAQK 2115
Score = 51.2 bits (121), Expect = 2e-06
Identities = 79/382 (20%), Positives = 162/382 (42%), Gaps = 60/382 (15%)
Query: 90 VRNREQISVTLGDEMFDRKKRWESEIPDKGRFSR---TNIISDLEEQISELTAIIEQMNR 146
+R+ +Q + T + + + E + + S+ ++ ++ + E+T ++E+
Sbjct: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614
Query: 147 DHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEK 206
+ +S + + + +KQ ++ + +L+E E E L LK +++ Q
Sbjct: 615 ELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETL-------LKDKEIIFQAH 667
Query: 207 LEEMGKEYKYLKNMFRTYQDSIYDEMEE---------------KWSKQKAKWKKDEKF-E 250
+EEM ++ ++ +T +S+ E+ E K K K + + K E
Sbjct: 668 IEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDE 727
Query: 251 RENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELR 310
++N QQ + K+ E+ +K + + + + E ++E+++ LK+HQ+ LE
Sbjct: 728 QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL-ELLLKERDKHLKEHQAHVENLEADI 786
Query: 311 KTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAI 370
K E +L + Q Q H Q T Y QL ++K +
Sbjct: 787 KRSE---------GELQQASAKLDVFQSYQSATHEQ--------TKAYEEQLAQLQQKLL 829
Query: 371 VGNLEKMLQTK-FAETEEKYKHTIQILTEENIH------LKQKIISKNEEICEGCSGRLA 423
E++L TK AE E + K + TE + H L Q++ +N E+ E L
Sbjct: 830 DLETERILLTKQVAEVEAQKK---DVCTELDAHKIQVQDLMQQLEKQNSEM-EQKVKSLT 885
Query: 424 SITVSKDDSDTVQDGSKKGQES 445
+ SK ++DG+K+ +++
Sbjct: 886 QVYESK-----LEDGNKEQEQT 902
Score = 48.1 bits (113), Expect = 2e-05
Identities = 77/365 (21%), Positives = 150/365 (41%), Gaps = 38/365 (10%)
Query: 89 LVRNREQISVTLGDEMFDRKKRWESEIPDKGRF-----SRTNIISDLEEQISELTAIIEQ 143
L +E + L + + + +K + + +K + N+I LE+ + A ++
Sbjct: 312 LTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKR 371
Query: 144 MNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAA 203
+ ++ +++ R +M E + +++ A ELE A K E+ A
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEE--A 429
Query: 204 QEKLE-EMGKEYK-----------YLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFER 251
+ KL+ EM ++ K L+ + + D M++ +Q AK +K
Sbjct: 430 RRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK----LH 485
Query: 252 ENILLQQKKKMTKKF---EMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEE 308
E L ++++++TKK E E E+ K E + + QEKE Q ++L LEE
Sbjct: 486 EKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKE------QQESLALEE 539
Query: 309 LRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNL-YYTQLELQKE 367
L K+ + + ++++ E + + E+ N + LE +K
Sbjct: 540 LELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 368 KAIVGNLEKMLQTKFAETE-EKYKHTIQILTEENIH-LKQKIISKNEEICEGCSGRLASI 425
K N E + + +TE E KH L E + LKQ+ ++ E++ E C ++
Sbjct: 600 K---HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETL 656
Query: 426 TVSKD 430
K+
Sbjct: 657 LKDKE 661
Score = 45.8 bits (107), Expect = 8e-05
Identities = 71/338 (21%), Positives = 155/338 (45%), Gaps = 69/338 (20%)
Query: 130 LEEQISELTAIIEQMNR---DHQSAQKLLS-----SEMDLRCAEMK----QNFENKNREL 177
L++QI++L ++++ ++ +HQ+ + L SE +L+ A K Q++++ E
Sbjct: 754 LKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQ 813
Query: 178 KEAHEAELSELENNYK------------------------AALKAEKLAAQEKLEEMGKE 213
+A+E +L++L+ L A K+ Q+ ++++ K+
Sbjct: 814 TKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQ 873
Query: 214 YKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEME---- 269
++ ++ +Y+ E +K++ + K+ E+EN++LQ ++ K+ E+
Sbjct: 874 NSEMEQKVKSLTQ-VYESKLEDGNKEQEQTKQI-LVEKENMILQMREGQKKEIEILTQKL 931
Query: 270 SGEEDKK--INESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWH 327
S +ED +NE F+N ++K E +KQ + ++E K K + DQ +
Sbjct: 932 SAKEDSIHILNEEYETKFKNQ-EKKMEKVKQKAKE---MQETLKKKLL----DQEAKLKK 983
Query: 328 DVLQQLLLMQVMQEELHAQALILESLNT---NLYYTQLEL-QKEKA-------------I 370
++ L + +++ +A+ L + N+ + ++LE QKE+ +
Sbjct: 984 ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDV 1043
Query: 371 VGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKII 408
+ EK L + E +E ++ +Q +E LKQKI+
Sbjct: 1044 ISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKIL 1081
Score = 43.9 bits (102), Expect = 3e-04
Identities = 69/366 (18%), Positives = 161/366 (43%), Gaps = 39/366 (10%)
Query: 53 QPTKPVVSPKMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWE 112
Q + ++ K I A EE N+ E ++V E +S L + + R K E
Sbjct: 651 QEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQ-----TELESLSSELSEVLKARHKLEE 705
Query: 113 --SEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNF 170
S + D+ + + + ++EQ + ++ + ++H+ + + + + +++
Sbjct: 706 ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLL 765
Query: 171 ENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYD 230
+ +++ LKE H+A + LE + K + + E A KL+ +F++YQ + ++
Sbjct: 766 KERDKHLKE-HQAHVENLEADIKRS-EGELQQASAKLD-----------VFQSYQSATHE 812
Query: 231 EMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQ 290
+ + + +K E E ILL ++ E+E+ ++D C+ + + IQ
Sbjct: 813 QTKAYEEQLAQLQQKLLDLETERILLTKQVA-----EVEAQKKDV-----CTELDAHKIQ 862
Query: 291 EKEELLKQHQSDTLQLEELRK--TKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQAL 348
++L++Q + ++E+ K T+ + + N+ +Q Q++ E+ +
Sbjct: 863 V-QDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK------EQEQTKQILVEKENMILQ 915
Query: 349 ILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKII 408
+ E + +L ++ + L + +TKF E+K + Q E LK+K++
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975
Query: 409 SKNEEI 414
+ ++
Sbjct: 976 DQEAKL 981
Score = 36.6 bits (83), Expect = 0.047
Identities = 59/304 (19%), Positives = 123/304 (40%), Gaps = 46/304 (15%)
Query: 131 EEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELEN 190
+EQI+ L ++Q N+ L EM+ ++M++ N ELK + A + ELE+
Sbjct: 1478 DEQINLLKEELDQQNKRFDC----LKGEMEDDKSKMEKKESNLETELK-SQTARIMELED 1532
Query: 191 -----------------NYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEME 233
NY E +KL+ + + N + ++ I
Sbjct: 1533 HITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLEN 1592
Query: 234 EKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKE 293
+ +S + K ++ E N+ ++ K++ K ED+ +ES + + E + ++
Sbjct: 1593 QVYSMKAELETKKKELEHVNLSVKSKEEELKAL------EDRLESESAAKLAELKRKAEQ 1646
Query: 294 ELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQL-LLMQVMQEELHAQALILES 352
++ + Q+EE + +Q + L +L +Q + E+H L+S
Sbjct: 1647 KIAAIKKQLLSQMEE---------KEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697
Query: 353 LNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNE 412
+ ++ Q E IV K + + E + +Q EE I + Q+ +++ E
Sbjct: 1698 VESS--------QSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE 1749
Query: 413 EICE 416
++ +
Sbjct: 1750 KLLQ 1753
Score = 35.8 bits (81), Expect = 0.081
Identities = 62/335 (18%), Positives = 135/335 (40%), Gaps = 50/335 (14%)
Query: 102 DEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDL 161
+++ + K + + K + +LE EL+ +Q N + S+ +
Sbjct: 957 EKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISD 1016
Query: 162 RCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQE----KLEEMGKEYKYL 217
+ ++ N + + L E H EL+++ + ++ L + QE +L+E +E L
Sbjct: 1017 AVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAEL 1076
Query: 218 KNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKI 277
K Q + E++ ++ W K+E +++ L + ++++ +K
Sbjct: 1077 K------QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK------------ 1118
Query: 278 NESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQ 337
+ N + + E LK H + L+++ + KE + + +QL+ ++
Sbjct: 1119 -----SAHVNSLAQDETKLKAH-LEKLEVDLNKSLKENTF-----------LQEQLVELK 1161
Query: 338 VMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILT 397
++ EE + + L + L T E Q K+ K L+ K E ++ L+
Sbjct: 1162 MLAEEDKRK---VSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK--------LS 1210
Query: 398 EENIHLKQKIISKNEEICEGCSGRLASITVSKDDS 432
EE K E + E + L +I+ SK ++
Sbjct: 1211 EELAIQLDICCKKTEALLEAKTNELINISSSKTNA 1245
Score = 35.8 bits (81), Expect = 0.081
Identities = 68/304 (22%), Positives = 120/304 (39%), Gaps = 49/304 (16%)
Query: 123 RTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHE 182
+T +S+LE Q+ +LT +N Q A L E + + MK + E+ L E
Sbjct: 1267 KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE-EKENQIKSMKADIES----LVTEKE 1321
Query: 183 AELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAK 242
A E N +AA + E Q K KE N ++ + ++ E S K
Sbjct: 1322 ALQKEGGNQQQAASEKESCITQLK-----KELSENINAVTLMKEELKEKKVEISSLSK-- 1374
Query: 243 WKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQS- 301
+ N+ LQ +++K + S++ + + +EK ELL Q Q
Sbjct: 1375 -----QLTDLNVQLQNSISLSEK------------EAAISSLRKQYDEEKCELLDQVQDL 1417
Query: 302 ----DTLQLEELRKTKEV--------PWRRDQINRHWHDVLQQLLLMQVMQEELHAQALI 349
DTL E++ ++V W++ +R Q + +Q EL ++
Sbjct: 1418 SFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQH--QNTVKELQIQLELKSKEAY 1475
Query: 350 LESLNTNLYYTQLELQKEK--AIVGNLE---KMLQTKFAETEEKYKHTIQILTEENIHLK 404
+ NL +L+ Q ++ + G +E ++ K + E + K + E H+
Sbjct: 1476 EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHIT 1535
Query: 405 QKII 408
QK I
Sbjct: 1536 QKTI 1539
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 57.4 bits (137), Expect = 3e-08
Identities = 65/298 (21%), Positives = 144/298 (48%), Gaps = 33/298 (11%)
Query: 136 ELTAIIEQMNRDHQSAQKL---LSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNY 192
EL + ++ H+ A + L+ E D E+ +N N ELK+ + +EL+
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTIT-NEELKKKN----AELQEKL 234
Query: 193 KAALKAEKLAAQEKLEEMGKEYKYLKNMF-----RTYQDSIYDEMEEKWSKQKAKWKKDE 247
A ++EK Q ++E+ ++ + K + T Q+ ++ + EE ++K K++E
Sbjct: 235 PLA-ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEE 293
Query: 248 KF--------ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFE--NFIQEKEELLK 297
K E+E + +Q++KM ++ E E++K++ E + E +++E++ +
Sbjct: 294 KMWRQEERLREQEGKMREQEEKMWRQ-EKRLREQEKELREQEKELREQKELREQEEQMQE 352
Query: 298 QHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNL 357
Q + Q E++R+ +E WR+++ R W Q M+ ++++ Q + + L
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEE--RLWEQEKQ----MREQEQKMRDQEERMWEQDERL 406
Query: 358 YYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQ--ILTEENIHLKQKIISKNEE 413
+ +++++ + +EKM + K + +EK + + EE I ++K + + EE
Sbjct: 407 REKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
Score = 56.6 bits (135), Expect = 4e-08
Identities = 65/344 (18%), Positives = 161/344 (46%), Gaps = 38/344 (11%)
Query: 103 EMFDRKKR-WESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDL 161
+M D+++R WE + + + R + EQ+ ++ + ++ ++ + + +
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEE 450
Query: 162 RCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMF 221
R E ++ + ++E E + EN ++ + EK Q++L E KE + +
Sbjct: 451 RIREREKKMREEEETMREQEEKMQKQEENMWE---QEEKEWQQQRLPEQ-KEKLWEQEKM 506
Query: 222 RTYQDSIYDE------MEEKWSKQKAKWKKDEKF-ERENILLQQKKKM----------TK 264
+ ++ I+++ EE W ++K W + EK E+E+ + +Q++KM +
Sbjct: 507 QEQEEKIWEQEEKIRDQEEMWGQEKKMW-RQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 565
Query: 265 KFEMESGEEDKKI--------NESCSAVFENFIQEKEELLKQHQSDTLQLEE-LRKTKEV 315
+ E ++ E++KK E E ++E+EE++++ + + EE +++ +E
Sbjct: 566 RMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625
Query: 316 PWRRDQ-INRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLE----LQKEKAI 370
W +++ + + +Q M +E++ Q + E + +++ +Q+++
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 371 VGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEEI 414
+ EKM + K E E+K ++ EE++ ++K + + EE+
Sbjct: 686 IWEQEKM-EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEM 728
Score = 55.8 bits (133), Expect = 8e-08
Identities = 67/334 (20%), Positives = 145/334 (43%), Gaps = 32/334 (9%)
Query: 93 REQISVTLGDEMFDRK--KRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQS 150
REQ + +E + K WE E +K R + E + + EQ +
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQE--EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ 395
Query: 151 AQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEM 210
+++ + LR E + + K E E E E K + EK+ +E++ E
Sbjct: 396 EERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER 455
Query: 211 GKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMES 270
K+ + + R ++ + + E W +++ +W++ L +QK+K+ ++ +M+
Sbjct: 456 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR-------LPEQKEKLWEQEKMQ- 507
Query: 271 GEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWR-----RDQINRH 325
E+++KI E E I+++EE+ Q + Q E++R+ ++ W RDQ +
Sbjct: 508 -EQEEKIWEQ-----EEKIRDQEEMWGQEKKMWRQ-EKMREQEDQMWEQEEKMRDQEQKM 560
Query: 326 WHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQ---TKF 382
W + Q +++ Q + + + ++++E+ ++ E+ +Q K
Sbjct: 561 WDQEERMEKKTQEQEKKTWDQEEKMRE-EERMREREKKMREEEEMMREQEEKMQEQEEKM 619
Query: 383 AETEEKYKHTIQILTEENIHLKQKIISKNEEICE 416
E EEK + + E+ ++K+ + E++ E
Sbjct: 620 QEQEEKMWEQEEKMQEQ----EEKMWEQEEKMWE 649
Score = 54.3 bits (129), Expect = 2e-07
Identities = 60/292 (20%), Positives = 127/292 (43%), Gaps = 21/292 (7%)
Query: 102 DEMFDR-KKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMD 160
+EM+ + KK W E + + +Q ++ E+M + Q +K + +
Sbjct: 524 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE 583
Query: 161 LRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQE-KLEEMGKEYKYLKN 219
+M++ + RE K E E+ E K + EK+ QE K+ E ++ + +
Sbjct: 584 ----KMREEERMREREKKMREEEEMMR-EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE 638
Query: 220 MFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINE 279
++ ++++ E+ W +Q+ +K++ +E E + Q+K + ++ E + +KK E
Sbjct: 639 KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE 698
Query: 280 SCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVM 339
++ +EE +++ + + EE+ + +E + +Q MQ
Sbjct: 699 QEKKTWDQEKMREEESMREREKKMREEEEMMREQE------------EKMQEQEEKMQEQ 746
Query: 340 QEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKML-QTKFAETEEKYK 390
+EE+ Q + + + Q L ++K + EKM Q K E EEK +
Sbjct: 747 EEEMWEQEEKMWEQEEKM-WEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMR 797
Score = 52.8 bits (125), Expect = 6e-07
Identities = 55/242 (22%), Positives = 115/242 (47%), Gaps = 23/242 (9%)
Query: 88 QLVRNREQISVTLGDEMFDRK-KRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNR 146
+++R +E+ ++M +++ K WE E + + + + + EE++ E + + R
Sbjct: 603 EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK---MWEQEEKMWEQEEKMWEQQR 659
Query: 147 DHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEK 206
+ +KL E ++ E Q E K E +E E + E E K EK+ +E
Sbjct: 660 LPEQKEKLWEHEK-MQEQEKMQEQEEKIWE-QEKMEKKTQEQE---KKTWDQEKMREEES 714
Query: 207 LEEMGKEYKYLKNMFRTYQDSIYDEME-------EKWSKQKAKWKKDEKFERENILLQQK 259
+ E K+ + + M R ++ + ++ E E W +++ W+++EK + L +QK
Sbjct: 715 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK 774
Query: 260 KKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRR 319
+K+ +E E +E +KI E E ++E++ Q + Q E++R +E W +
Sbjct: 775 EKL---WEHEKMQEQEKIWEQ----EEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQ 827
Query: 320 DQ 321
++
Sbjct: 828 EE 829
Score = 51.2 bits (121), Expect = 2e-06
Identities = 58/288 (20%), Positives = 126/288 (43%), Gaps = 20/288 (6%)
Query: 131 EEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAE--MKQNFENKNRELKEAHEAELSEL 188
EE + + EQ + + +K+ E LR E M++ E R+ K E E
Sbjct: 272 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR 331
Query: 189 ENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEK 248
E + + E +E+++E ++ + R ++ ++ + E W ++K ++++K
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 249 F-ERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLE 307
++E + +Q +++ +K E E +K+ E + E +++E + Q + +Q E
Sbjct: 392 MRDQEERMWEQDERLREK--EERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE 449
Query: 308 ELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKE 367
E + +E R ++ + +Q MQ +E + Q + Q L ++
Sbjct: 450 ERIREREKKMREEE-----ETMREQEEKMQKQEENMWEQ--------EEKEWQQQRLPEQ 496
Query: 368 KAIVGNLEKM--LQTKFAETEEKYKHTIQILTEENIHLKQKIISKNEE 413
K + EKM + K E EEK + ++ +E +Q+ + + E+
Sbjct: 497 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Score = 40.0 bits (92), Expect = 0.004
Identities = 31/176 (17%), Positives = 81/176 (46%), Gaps = 8/176 (4%)
Query: 108 KKRWESEI--PDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAE 165
KK W+ E ++ R + + EE + E +++ Q ++ + + + +
Sbjct: 701 KKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQ 760
Query: 166 MKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQE-KLEEMGKEYKYLKNMFRTY 224
++ +E + ++ E +++ K + EK+ QE K+ ++ + + R
Sbjct: 761 EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820
Query: 225 QDSIYDEMEEKWSKQKAKWKKDEKF-----ERENILLQQKKKMTKKFEMESGEEDK 275
++ ++ + E+ W +++ W ++EK + E + Q++KM ++ E G+E+K
Sbjct: 821 EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEK 876
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 57.4 bits (137), Expect = 3e-08
Identities = 36/197 (18%), Positives = 97/197 (49%), Gaps = 13/197 (6%)
Query: 131 EEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELEN 190
EEQ+ E +++ Q ++ + + + + +Q E + + LK+ + E E
Sbjct: 233 EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTG 292
Query: 191 NYKAALKAEKLAAQEKLEEMGKEYKYLKNM---FRTYQDSIYDEMEEKWSKQKAKWKKDE 247
+ ++ ++ +E+ E+M ++ + ++ ++ ++++ E+ W +++ WK++E
Sbjct: 293 EQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEE 352
Query: 248 KF-ERENILLQQKKKMTKKFEMESGEED---------KKINESCSAVFENFIQEKEELLK 297
+ E+E + +Q++++ K+ E +E+ +K E E ++KE++ +
Sbjct: 353 QMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMRE 412
Query: 298 QHQSDTLQLEELRKTKE 314
Q + Q E++RK +E
Sbjct: 413 QEEQMGEQKEQMRKQEE 429
Score = 46.6 bits (109), Expect = 5e-05
Identities = 43/285 (15%), Positives = 131/285 (45%), Gaps = 28/285 (9%)
Query: 127 ISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELS 186
+ + E Q+ E + + Q+ E + + E ++ + + ++ E E
Sbjct: 173 VREQEGQVREQEGQVREQE-GQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK 231
Query: 187 ELEN--NYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWK 244
+ E + ++ ++ Q++ E+M K+ + ++ Q+ E EE+ KQK + +
Sbjct: 232 QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMRE-----QEEQMREQEEQMLKQKEQTE 286
Query: 245 KDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTL 304
++E+ + ++++++ ++ E + E+++++ E ++E++ KQ +
Sbjct: 287 QEEQTGEQEEQMREQEEQMREQEEQMREQEEQMRE-----------QEEQMGKQEEQMWE 335
Query: 305 QLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLEL 364
Q E++ + KE W++++ + +Q MQ +E++ Q + + + ++
Sbjct: 336 QKEQMWEQKEQMWKQEE------QMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389
Query: 365 QKEKAIVGNLEKML---QTKFAETEEKYKHTIQILTEENIHLKQK 406
+K++ +G ++ + + + E EE+ + + ++ H+ ++
Sbjct: 390 RKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQ 434
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 57.4 bits (137), Expect = 3e-08
Identities = 85/382 (22%), Positives = 159/382 (41%), Gaps = 58/382 (15%)
Query: 69 RQEETNKSFYE--------VINVSPG------YQLVRNREQISVTLGD---------EMF 105
RQ ET K+ E ++N S G +Q+ R Q++ GD ++
Sbjct: 275 RQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQIS 334
Query: 106 DRKKRWESEIPDKGRFSR--TNIISDLEEQISELTAIIEQMNRDHQSAQ----KLLSSEM 159
++ ++ E + RF R DLE+Q+S+L Q+N +++ K
Sbjct: 335 KQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRV---QLNFSAMASELEEVKRCMERK 391
Query: 160 DLRCAEMKQNFENKNRELKEAHEAELSELEN-----NYKAALKAEKLAAQEKLEEMGKEY 214
D A + EN REL+ + +L L+ N+ +AE+ A ++ E+ +
Sbjct: 392 DKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHA 451
Query: 215 KYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEED 274
+ Y + + E ++ K ++D K + + + Q K K KK E ++
Sbjct: 452 EDATKQAERYLSEL--QQSEALKEEAEKRREDLKLKAQESIRQWKLKH-KKLERALEKQS 508
Query: 275 KKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLL 334
+ ++E + ++EK+EL Q + Q+E LRK +DVL +
Sbjct: 509 ETVDE-LTGKNNQILKEKDELKTQLYAALQQIENLRK-------------ELNDVLTKRA 554
Query: 335 LMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQ 394
L +EELH++ L + ++ +LE++ + LE L+ K ++ + + K
Sbjct: 555 L---QEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELK-KQSKIQSQMKVEKA 610
Query: 395 ILTEENIHLKQKIISKNEEICE 416
L EE LK+ ++ E
Sbjct: 611 HLEEEIAELKKSQAQDKAKLLE 632
Score = 36.2 bits (82), Expect = 0.062
Identities = 60/236 (25%), Positives = 106/236 (44%), Gaps = 48/236 (20%)
Query: 128 SDLEEQISELTA-IIEQMN--RDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAE 184
S+ E I L A +E+ N + H+ + L S+ D E+ QN EN+N++LK ++
Sbjct: 727 SEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQN-ENENKKLKLKYQCL 785
Query: 185 LSELENNYK-AALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIY-------------- 229
+LE K +++ E L ++EE + K T Q+SI
Sbjct: 786 KDQLEEREKHISIEEEHL---RRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTF 842
Query: 230 --DEMEE---------------KW---SKQKAKWKKDEKFERENILLQQKKK-MTKKFEM 268
D +E+ +W SK K +W +E EREN + + M + ++
Sbjct: 843 SKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREKNLRHQLMLCRQQL 902
Query: 269 ESGEEDKKINESCSAVFENFIQEKEELLKQ-HQSDTLQLEEL-RKTKEVPWRRDQI 322
+ E+K+ C +F+ I+ +E+LL + H+ LEE RK +E+ +D++
Sbjct: 903 RNLTENKESELQC--LFQQ-IERQEQLLDEIHREKRDLLEETQRKDEEMGSLQDRV 955
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 57.0 bits (136), Expect = 3e-08
Identities = 93/425 (21%), Positives = 174/425 (40%), Gaps = 77/425 (18%)
Query: 64 KIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGD-------EMFDRKKRWES--- 113
KIH+ E TN +S Y V+ E++ +TL D E+ D KK++E
Sbjct: 827 KIHALTSENTNLKKM----MSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQ 882
Query: 114 ---EIPDKGRFSRTNIIS----------DLEEQISELTAIIEQMNRDHQSAQKLLSS--- 157
+I DK + N+ + L E ++++++ + M + S ++L++
Sbjct: 883 EFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRK 942
Query: 158 ---EMDLRCAEMKQNFENKNR-----ELKEAHEAELSELENNYKAALKAEK--------- 200
E+ AE+K + + ++K A E E +KA K K
Sbjct: 943 GQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQK 1002
Query: 201 -LAAQEKLEEMGKEYKYLKNMFRTYQDSIYDE---MEEKWSKQKAKWKKDEKFERENILL 256
++E++++ +E LK T Q + D+ +E+ ++A +K ++ ++ L
Sbjct: 1003 YSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1062
Query: 257 QQKKKMTKKFEMESGEEDKKINESCSAVFENFIQ------EKEELLKQHQSDTLQ--LEE 308
QK K + + EE+ K AV +N +Q E+ E LK+ + T++ EE
Sbjct: 1063 SQKYTEVKNVKEKLVEENAKQTSEILAV-QNLLQKQHVPLEQVEALKKSLNGTIENLKEE 1121
Query: 309 LRKTKEVPWRRDQINRHWHDVLQQ-----------LLLMQVMQEELHAQALILESLNTNL 357
L+ + + Q H +L+ L + + ++E+ L
Sbjct: 1122 LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEES 1181
Query: 358 YYTQLELQKEKAIVGNLE---KMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKN--- 411
E+ K ++ V N + K L+T+ KYK T L + L +K+ + N
Sbjct: 1182 QNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKY 1241
Query: 412 EEICE 416
EE+CE
Sbjct: 1242 EEVCE 1246
Score = 40.0 bits (92), Expect = 0.004
Identities = 75/362 (20%), Positives = 148/362 (40%), Gaps = 90/362 (24%)
Query: 127 ISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHE---A 183
+ D+++++ E ++QM + ++ L+SE + + +++ ++LK +E A
Sbjct: 486 LKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASA 545
Query: 184 ELSELENNYK-------------AALKAEKLAAQEKLE--EMGKEYKYLK---------- 218
E+ +L N K L E Q++L EM +E K K
Sbjct: 546 EVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKE 605
Query: 219 -----------NMFRTYQDSIYDEMEEKWSKQKAKWKKDEKF---------ERENILL-- 256
F + S+ +E+ EK K ++ EK E EN+
Sbjct: 606 LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKL 665
Query: 257 ------QQKKKMTKKFEMESGEEDKKI------NESCSAVFENFIQEKEELLKQHQSDTL 304
++ +++ + E +SGE KKI N++ E + + L +Q + T+
Sbjct: 666 AQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTI 725
Query: 305 QL----------EELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLN 354
++ E+++K+ + D +NR DV Q + +++L + L+LE+ +
Sbjct: 726 EMKNHYVPLKVSEDMKKSHDA--IIDDLNRKLLDVTQ-----KYTEKKLEMEKLLLENDS 778
Query: 355 TNLYYTQLEL------QKEKAIVGNLEKMLQTKFAETEEKYK-----HTIQILTEENIHL 403
+ ++LE + EK I+ +++ K +E K K I LT EN +L
Sbjct: 779 LSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNL 838
Query: 404 KQ 405
K+
Sbjct: 839 KK 840
Score = 30.4 bits (67), Expect = 3.4
Identities = 31/178 (17%), Positives = 71/178 (39%), Gaps = 20/178 (11%)
Query: 108 KKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSA--QKLLSSEMDLRCAE 165
KK E+ D ++ T SDLE QIS L + +NR ++ + L + + ++ +
Sbjct: 1203 KKLETREVVDLSKYKATK--SDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD 1260
Query: 166 MKQ----NFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMF 221
K+ + E + ++ KE + L+ + Q +++E K+ + N
Sbjct: 1261 EKELLHFSIEQEIKDQKERCDKSLTTITE------------LQRRIQESAKQIEAKDNKI 1308
Query: 222 RTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINE 279
+ + + + + +R++ L+ + K E + + D++ E
Sbjct: 1309 TELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQE 1366
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 57.0 bits (136), Expect = 3e-08
Identities = 93/425 (21%), Positives = 174/425 (40%), Gaps = 77/425 (18%)
Query: 64 KIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGD-------EMFDRKKRWES--- 113
KIH+ E TN +S Y V+ E++ +TL D E+ D KK++E
Sbjct: 840 KIHALTSENTNLKKM----MSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQ 895
Query: 114 ---EIPDKGRFSRTNIIS----------DLEEQISELTAIIEQMNRDHQSAQKLLSS--- 157
+I DK + N+ + L E ++++++ + M + S ++L++
Sbjct: 896 EFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRK 955
Query: 158 ---EMDLRCAEMKQNFENKNR-----ELKEAHEAELSELENNYKAALKAEK--------- 200
E+ AE+K + + ++K A E E +KA K K
Sbjct: 956 GQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQK 1015
Query: 201 -LAAQEKLEEMGKEYKYLKNMFRTYQDSIYDE---MEEKWSKQKAKWKKDEKFERENILL 256
++E++++ +E LK T Q + D+ +E+ ++A +K ++ ++ L
Sbjct: 1016 YSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDL 1075
Query: 257 QQKKKMTKKFEMESGEEDKKINESCSAVFENFIQ------EKEELLKQHQSDTLQ--LEE 308
QK K + + EE+ K AV +N +Q E+ E LK+ + T++ EE
Sbjct: 1076 SQKYTEVKNVKEKLVEENAKQTSEILAV-QNLLQKQHVPLEQVEALKKSLNGTIENLKEE 1134
Query: 309 LRKTKEVPWRRDQINRHWHDVLQQ-----------LLLMQVMQEELHAQALILESLNTNL 357
L+ + + Q H +L+ L + + ++E+ L
Sbjct: 1135 LKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEES 1194
Query: 358 YYTQLELQKEKAIVGNLE---KMLQTKFAETEEKYKHTIQILTEENIHLKQKIISKN--- 411
E+ K ++ V N + K L+T+ KYK T L + L +K+ + N
Sbjct: 1195 QNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKY 1254
Query: 412 EEICE 416
EE+CE
Sbjct: 1255 EEVCE 1259
Score = 40.0 bits (92), Expect = 0.004
Identities = 75/362 (20%), Positives = 148/362 (40%), Gaps = 90/362 (24%)
Query: 127 ISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHE---A 183
+ D+++++ E ++QM + ++ L+SE + + +++ ++LK +E A
Sbjct: 499 LKDVQKRMYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASA 558
Query: 184 ELSELENNYK-------------AALKAEKLAAQEKLE--EMGKEYKYLK---------- 218
E+ +L N K L E Q++L EM +E K K
Sbjct: 559 EVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKE 618
Query: 219 -----------NMFRTYQDSIYDEMEEKWSKQKAKWKKDEKF---------ERENILL-- 256
F + S+ +E+ EK K ++ EK E EN+
Sbjct: 619 LSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKL 678
Query: 257 ------QQKKKMTKKFEMESGEEDKKI------NESCSAVFENFIQEKEELLKQHQSDTL 304
++ +++ + E +SGE KKI N++ E + + L +Q + T+
Sbjct: 679 AQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTI 738
Query: 305 QL----------EELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLN 354
++ E+++K+ + D +NR DV Q + +++L + L+LE+ +
Sbjct: 739 EMKNHYVPLKVSEDMKKSHDA--IIDDLNRKLLDVTQ-----KYTEKKLEMEKLLLENDS 791
Query: 355 TNLYYTQLEL------QKEKAIVGNLEKMLQTKFAETEEKYK-----HTIQILTEENIHL 403
+ ++LE + EK I+ +++ K +E K K I LT EN +L
Sbjct: 792 LSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNL 851
Query: 404 KQ 405
K+
Sbjct: 852 KK 853
Score = 30.4 bits (67), Expect = 3.4
Identities = 31/178 (17%), Positives = 71/178 (39%), Gaps = 20/178 (11%)
Query: 108 KKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSA--QKLLSSEMDLRCAE 165
KK E+ D ++ T SDLE QIS L + +NR ++ + L + + ++ +
Sbjct: 1216 KKLETREVVDLSKYKATK--SDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKD 1273
Query: 166 MKQ----NFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMF 221
K+ + E + ++ KE + L+ + Q +++E K+ + N
Sbjct: 1274 EKELLHFSIEQEIKDQKERCDKSLTTITE------------LQRRIQESAKQIEAKDNKI 1321
Query: 222 RTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINE 279
+ + + + + +R++ L+ + K E + + D++ E
Sbjct: 1322 TELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQE 1379
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 57.0 bits (136), Expect = 3e-08
Identities = 78/353 (22%), Positives = 151/353 (42%), Gaps = 45/353 (12%)
Query: 38 KLTPLVPAPKNHNYLQPTKPV---VSPKMKIHSARQEETNKSFYEVINVSPGYQLVRNRE 94
K+ PL+ + + + K + ++ AR++E + ++ QL E
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 896
Query: 95 QISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNRDHQSAQKL 154
Q D + D ++R + I +K + + ++ E++ + E+MN + + ++
Sbjct: 897 Q------DNLNDAEERCDQLIKNKIQLEAK--VKEMNERLEDE----EEMNAELTAKKRK 944
Query: 155 LSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEY 214
L E C+E+K++ ++ L + E E EN K L E E + ++ KE
Sbjct: 945 LEDE----CSELKKDIDDLELTLAKV-EKEKHATENKVKN-LTEEMAGLDEIIAKLTKEK 998
Query: 215 KYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEED 274
K L+ + D + E ++ S K+K K +++ + L+Q+KK+ E +
Sbjct: 999 KALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRK-- 1056
Query: 275 KKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLL 334
E ++ +E + ++D LQLEE K KE + +Q N D +Q+L
Sbjct: 1057 ----------LEGDLKLTQESIMDLENDKLQLEEKLKKKE--FDINQQNSKIED--EQVL 1102
Query: 335 LMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEE 387
+Q+ ++ QA I E + EL+ E+ +EK+ E EE
Sbjct: 1103 ALQLQKKLKENQARIEE--------LEEELEAERTARAKVEKLRSDLSRELEE 1147
Score = 40.8 bits (94), Expect = 0.003
Identities = 68/356 (19%), Positives = 155/356 (43%), Gaps = 58/356 (16%)
Query: 88 QLVRNREQISVTLGD--EMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMN 145
QL++N+ Q+ + + E + ++ +E+ K R + S+L++ I +L + ++
Sbjct: 909 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKR-KLEDECSELKKDIDDLELTLAKVE 967
Query: 146 RDHQSAQ---KLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELE---------NNYK 193
++ + + K L+ EM E+ + + L+EAH+ L +L+ + K
Sbjct: 968 KEKHATENKVKNLTEEM-AGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSK 1026
Query: 194 AALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFEREN 253
L+ + + LE+ K L+ R + + E + K + +EK +++
Sbjct: 1027 VKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKE 1086
Query: 254 ILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEEL---- 309
+ Q+ + ++ + + KK+ E+ + I+E EE L+ ++ ++E+L
Sbjct: 1087 FDINQQNSKIEDEQVLALQLQKKLKEN-----QARIEELEEELEAERTARAKVEKLRSDL 1141
Query: 310 -RKTKEVPWRRD----------QINRHWHDVLQQL---LLMQVMQEELHAQALILESLNT 355
R+ +E+ R + ++N+ Q++ L +Q E A AL + ++
Sbjct: 1142 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1201
Query: 356 ---------NLYYTQLELQKEKA--------IVGNLEKMLQTKFAETEEKYKHTIQ 394
NL + +L+KEK+ + N+E++++ K EK T++
Sbjct: 1202 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAK--ANLEKVSRTLE 1255
Score = 39.3 bits (90), Expect = 0.007
Identities = 70/340 (20%), Positives = 139/340 (40%), Gaps = 70/340 (20%)
Query: 126 IISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAEL 185
I +++E +++E +EQ R+HQ L + +D AE + N+ +K+ E +L
Sbjct: 1570 IKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLD---AETRS--RNEVLRVKKKMEGDL 1624
Query: 186 SELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYD--------------- 230
+E+E A ++AA E K+ K L+++ + Q + D
Sbjct: 1625 NEMEIQLS---HANRMAA-----EAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1676
Query: 231 ---------EMEE--------KWSKQKAKWKKDEKFERENI-------LLQQKKKMTKKF 266
E+EE + S++ A+ + E ER + L+ QKKKM
Sbjct: 1677 ERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDL 1736
Query: 267 EMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHW 326
E ++ + E +A +E+ K + EEL+K ++ +++ ++
Sbjct: 1737 TQLQSEVEEAVQECRNA--------EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1788
Query: 327 HDVLQQL--LLMQVMQEELHAQALILESLNTNLYYTQLELQKE-----KAIVG--NLEKM 377
++ L L + Q L L+ L + + EL+ E +++ G E+
Sbjct: 1789 EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERR 1848
Query: 378 LQTKFAETEEKYKHTIQIL-TEENIHLKQKIISKNEEICE 416
++ +TEE K+ +++ + + LK K + E E
Sbjct: 1849 IKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAE 1888
Score = 38.5 bits (88), Expect = 0.012
Identities = 73/308 (23%), Positives = 127/308 (41%), Gaps = 45/308 (14%)
Query: 130 LEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELE 189
L+ +I +L +E+ N + K ++NF+ E K+ +E SELE
Sbjct: 1423 LQNEIEDLMVDVERSNAAAAALDK------------KQRNFDKILAEWKQKYEESQSELE 1470
Query: 190 NNYKAA--LKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEE--KWSKQKAKWKK 245
++ K A L E + EE + + K + Q+ I D E+ + K + +K
Sbjct: 1471 SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEK 1530
Query: 246 DEK-FERENILLQQK-KKMTKKFEMESGEEDKKINE--SCSAVFENFIQEKEELLKQ--- 298
K E E + LQ ++ E E G+ + E A E + EK+E ++Q
Sbjct: 1531 VRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1590
Query: 299 -HQS--DTLQLE---ELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILES 352
HQ D+LQ E R EV + ++ +++ QL M E Q L+S
Sbjct: 1591 NHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQS 1650
Query: 353 LNTNLYYTQL----------ELQKEKAIVGNLEKMLQTKFAETE---EKYKHTIQILTEE 399
L L TQ+ +L++ AIV +LQ + E E+ + + ++ +E
Sbjct: 1651 L---LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQE 1707
Query: 400 NIHLKQKI 407
I +++
Sbjct: 1708 LIETSERV 1715
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 57.0 bits (136), Expect = 3e-08
Identities = 78/403 (19%), Positives = 159/403 (39%), Gaps = 56/403 (13%)
Query: 31 KNSTGSSKLTPLVPAPKNHNYLQPTKPVVSPKMKIHSARQEETNKSFYEVINVSPGYQLV 90
K GS T + P++ N PK + + T + +N+S L
Sbjct: 723 KEEIGSLSKTETILPPESEN----------PKENDNDSGTGSTADTSSIDLNLSISSFLS 772
Query: 91 RNREQISVTLGDEMFDRK--KRWESEIPDKGRFSRTN--IISDLEEQISELTAIIEQ--- 143
+ ++ S++L + +K K+ I D S T I++D + + EL + Q
Sbjct: 773 KTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELR 832
Query: 144 ----MNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAE 199
+ ++ Q AQ+ L+S++ + ++ + FE + K ++ E+ LE K ++
Sbjct: 833 ELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERL 892
Query: 200 KLAAQEKLE--------EMGKEYKYLKNMFRTYQDSIYDEME---EKWSKQKAKWKKDEK 248
+ +L E KE +NM + + + +E+E ++ K+ K +K+E
Sbjct: 893 EQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEEL 952
Query: 249 FERENI-------------------LLQQKKKMTKKFEMESGEEDKKINESCSAVF---- 285
+ ++ ++QQ+K E E +++ + A
Sbjct: 953 AQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELE 1012
Query: 286 ENFIQEKEELLKQHQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHA 345
E +QEK +LLKQ D ++ + K +Q+ R+ ++++L Q QE
Sbjct: 1013 ERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQT-QERARL 1071
Query: 346 QALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEK 388
+ T + + L+ + ++ +FA EEK
Sbjct: 1072 PKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEK 1114
Score = 38.1 bits (87), Expect = 0.016
Identities = 33/173 (19%), Positives = 79/173 (45%), Gaps = 3/173 (1%)
Query: 144 MNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNY-KAALKAEKLA 202
+ HQ ++ L + ++ ++ + E + +++ ++ + EL+N + + K+
Sbjct: 1016 LQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQ 1075
Query: 203 AQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKM 262
E M K L+ D D++++ ++ Q+ K +K+E+ + Q + +
Sbjct: 1076 RSEAKTRMAMFKKSLRINSTATPDQDRDKIKQ-FAAQEEKRQKNERMAQHQKHENQMRDL 1134
Query: 263 TKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQ-LEELRKTKE 314
+ E E + NE C + E+ Q+ +EL ++H + + E+LR K+
Sbjct: 1135 QLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKK 1187
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 56.6 bits (135), Expect = 4e-08
Identities = 81/377 (21%), Positives = 160/377 (42%), Gaps = 63/377 (16%)
Query: 84 SPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQ 143
SPG + +R+ +SV L D + +R E+ +K T + D ++++ ++ +++
Sbjct: 237 SPGMKRTESRQHLSVELADAKA-KIRRLRQELEEK-----TEQLLDCKQELEQMEIELKR 290
Query: 144 MNRDHQS------AQKLLSSEMD------LRCAEMKQNFENKNRELK--EAHEAELSELE 189
+ +++ + + ++ E+D +R +++ L E ++A + EL+
Sbjct: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 190 NNYKAALKAEKL---------AAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQK 240
+ + L+ + + A +KL E+ KE LK EME +
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM------EMERDMDR-- 402
Query: 241 AKWKKDEKFERENILLQQKKKMTKKFEMESG---EEDKKINESCSAVFENFIQEKEELLK 297
KK E+ EN+ L+ +K + + G E+ + +E A ++ E EL
Sbjct: 403 ---KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459
Query: 298 --------QHQSDTLQLEELRKTKE-VPWRRDQINRHWHDVLQQLLLMQVMQEELHAQAL 348
++QS T +EELR T + V +I + + + +++++ E+ +
Sbjct: 460 SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQ 519
Query: 349 ILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKII 408
L+ N +L KEKA LEK ++T E + I+IL +EN HL Q +
Sbjct: 520 SLQ----NCQNLSKDLMKEKA---QLEKTIET----LRENSERQIKILEQENEHLNQTVS 568
Query: 409 SKNEEICEGCSGRLASI 425
S + R+ I
Sbjct: 569 SLRQRSQISAEARVKDI 585
Score = 52.0 bits (123), Expect = 1e-06
Identities = 65/302 (21%), Positives = 138/302 (45%), Gaps = 37/302 (12%)
Query: 128 SDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSE 187
S L+E+ EL +E + ++ K+ +++ + E ++ K EL +A +
Sbjct: 697 SQLDEENLELRRNVESLKC---ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 188 LENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDE 247
LE +Y+ L E Q+ LE K+ + L++ + + +++ + K K+ E
Sbjct: 754 LEVSYQG-LDIENQRLQKTLENSNKKIQQLESELQDLEME-NQTLQKNLEELKISSKRLE 811
Query: 248 KFERENILLQQKKKMTKKFEMESGEEDKKIN----------ESCSAVFENFIQEKEELLK 297
+ E+EN L+Q+ +K + + +E+K++ E + N +E + L K
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 298 Q---HQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLN 354
+ ++ ++L+EL K + +R I+ + + ++E+L ++ L + +N
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATID---------IKTLVTLREDLVSEKLKTQQMN 922
Query: 355 TNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIH--LKQKIISKNE 412
+L EL+K I N E++L + + + +YK L E + LK+ + K E
Sbjct: 923 NDLEKLTHELEK---IGLNKERLLHDEQSTDDSRYK-----LLESKLESTLKKSLEIKEE 974
Query: 413 EI 414
+I
Sbjct: 975 KI 976
Score = 46.6 bits (109), Expect = 5e-05
Identities = 71/340 (20%), Positives = 145/340 (42%), Gaps = 48/340 (14%)
Query: 62 KMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRF 121
++KI S R E+ K + + QL ++++Q+ E +++ R ++EI D
Sbjct: 802 ELKISSKRLEQLEKENKSLEQETS--QLEKDKKQL------EKENKRLRQQAEIKDTTLE 853
Query: 122 SRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDL---RCAEMKQNFENKNRELK 178
I +LE++ K LS E+ + C +K+ E +N+EL
Sbjct: 854 ENNVKIGNLEKE------------------NKTLSKEIGIYKESCVRLKE-LEKENKELV 894
Query: 179 EAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSK 238
+ ++ L + L +EKL Q+ ++ K L+ + + ++DE S+
Sbjct: 895 KRATIDIKTLVT-LREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSR 953
Query: 239 QKAKWKKDEKFERENILLQQKKKMTKKFEME-SGEEDKKINESCSAVFENFIQEKEELLK 297
K K E ++++ ++++K + +E S ++++ + V +N+ E LK
Sbjct: 954 YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY-----EALK 1008
Query: 298 QHQSDTLQLEELRKT--KEVPWRRD--QINRHWHDVLQQLL-------LMQVMQEELHAQ 346
Q Q + ++ ++ W R+ + R V +L+ +Q ++ L Q
Sbjct: 1009 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1068
Query: 347 ALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETE 386
LE+ N NL L LQ++ + LQT+ A+ +
Sbjct: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1108
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 56.6 bits (135), Expect = 4e-08
Identities = 81/377 (21%), Positives = 160/377 (42%), Gaps = 63/377 (16%)
Query: 84 SPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQ 143
SPG + +R+ +SV L D + +R E+ +K T + D ++++ ++ +++
Sbjct: 237 SPGMKRTESRQHLSVELADAKA-KIRRLRQELEEK-----TEQLLDCKQELEQMEIELKR 290
Query: 144 MNRDHQS------AQKLLSSEMD------LRCAEMKQNFENKNRELK--EAHEAELSELE 189
+ +++ + + ++ E+D +R +++ L E ++A + EL+
Sbjct: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 190 NNYKAALKAEKL---------AAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQK 240
+ + L+ + + A +KL E+ KE LK EME +
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDM------EMERDMDR-- 402
Query: 241 AKWKKDEKFERENILLQQKKKMTKKFEMESG---EEDKKINESCSAVFENFIQEKEELLK 297
KK E+ EN+ L+ +K + + G E+ + +E A ++ E EL
Sbjct: 403 ---KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTS 459
Query: 298 --------QHQSDTLQLEELRKTKE-VPWRRDQINRHWHDVLQQLLLMQVMQEELHAQAL 348
++QS T +EELR T + V +I + + + +++++ E+ +
Sbjct: 460 SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQ 519
Query: 349 ILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIHLKQKII 408
L+ N +L KEKA LEK ++T E + I+IL +EN HL Q +
Sbjct: 520 SLQ----NCQNLSKDLMKEKA---QLEKTIET----LRENSERQIKILEQENEHLNQTVS 568
Query: 409 SKNEEICEGCSGRLASI 425
S + R+ I
Sbjct: 569 SLRQRSQISAEARVKDI 585
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/302 (21%), Positives = 139/302 (46%), Gaps = 38/302 (12%)
Query: 128 SDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELSE 187
S L+E+ EL +E + ++ K+ +++ + E ++ K EL +A +
Sbjct: 697 SQLDEENLELRRNVESLKC---ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER 753
Query: 188 LENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDE 247
LE +Y+ L E Q+ LE K+ + L++ + + +++ + K K+ E
Sbjct: 754 LEVSYQG-LDIENQRLQKTLENSNKKIQQLESELQDLEME-NQTLQKNLEELKISSKRLE 811
Query: 248 KFERENILLQQKKKMTKKFEMESGEEDKKIN----------ESCSAVFENFIQEKEELLK 297
+ E+EN L+Q+ +K + + +E+K++ E + N +E + L K
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 298 Q---HQSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQALILESLN 354
+ ++ ++L+EL K + +R I+ + + ++E+L ++ L + +N
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATID---------IKTLVTLREDLVSEKLKTQQMN 922
Query: 355 TNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIH--LKQKIISKNE 412
+L EL+K I N E++L + T+++YK L E + LK+ + K E
Sbjct: 923 NDLEKLTHELEK---IGLNKERLLHDE-QSTDDRYK-----LLESKLESTLKKSLEIKEE 973
Query: 413 EI 414
+I
Sbjct: 974 KI 975
Score = 43.9 bits (102), Expect = 3e-04
Identities = 69/340 (20%), Positives = 151/340 (44%), Gaps = 49/340 (14%)
Query: 62 KMKIHSARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRF 121
++KI S R E+ K + + QL ++++Q+ E +++ R ++EI D
Sbjct: 802 ELKISSKRLEQLEKENKSLEQETS--QLEKDKKQL------EKENKRLRQQAEIKDTTLE 853
Query: 122 SRTNIISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDL---RCAEMKQNFENKNRELK 178
I +LE++ K LS E+ + C +K+ E +N+EL
Sbjct: 854 ENNVKIGNLEKE------------------NKTLSKEIGIYKESCVRLKE-LEKENKELV 894
Query: 179 EAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEM--EEKW 236
+ ++ L + L +EKL Q+ ++ K L+ + + ++DE ++++
Sbjct: 895 KRATIDIKTLVT-LREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRY 953
Query: 237 ----SKQKAKWKKDEKFERENIL-LQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQE 291
SK ++ KK + + E I L+ + + + + + +E K + ++ A+ + Q+
Sbjct: 954 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR--QD 1011
Query: 292 KEELLKQH-----QSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQVMQEELHAQ 346
+E +++ + + + E T+E+ +D++ +V + +Q ++ L Q
Sbjct: 1012 EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI----EVERNNATLQAEKQALKTQ 1067
Query: 347 ALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETE 386
LE+ N NL L LQ++ + LQT+ A+ +
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1107
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 55.8 bits (133), Expect = 8e-08
Identities = 83/359 (23%), Positives = 171/359 (47%), Gaps = 67/359 (18%)
Query: 87 YQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNIISDLEEQISELTAIIEQMNR 146
++L N +I L E+ + K E DK R + +E+++ E + +M R
Sbjct: 226 FKLYHNEVEIE-KLNKELASKNKEIEK---DKKRMDK------VEDELKEKKKELGKMMR 275
Query: 147 DHQSAQKLLS---SEMDLRCAEMKQNFENKNRELK--EAHEAELSELENNYKAA------ 195
+ Q +K + SE++ + + + EN + ++K EA + L + +YK
Sbjct: 276 EQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDE 335
Query: 196 LKAEKLA---AQEKLEEMGKEYKYLKNMFRTYQDSI---YDEMEEKWSKQKA-------K 242
L+ E L+ A+++ EE +E + T +++ Y ++E+ SK+ A K
Sbjct: 336 LEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEK 395
Query: 243 WKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLKQHQSD 302
+ +D+K +++ + L+++KK+ E + KI + + EN Q++ E L+++ +
Sbjct: 396 FNRDQKADQDRLDLEERKKV---------ETEAKIKQKLREIEEN--QKRIEKLEEYITT 444
Query: 303 TLQ-LEELRK-----TKEVPW---RRDQINRHWHDVLQQLLLMQVMQEELHAQ---ALIL 350
+ Q LEE +K T+EV R D+IN+ + V++QL ++ ++E Q A I+
Sbjct: 445 SKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIM 504
Query: 351 ESLNT----NLYYTQLEL------QKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEE 399
ES+ ++Y ++L + + A+ L K + ++E+ + IQ + E+
Sbjct: 505 ESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQ 563
Score = 43.5 bits (101), Expect = 4e-04
Identities = 69/350 (19%), Positives = 145/350 (41%), Gaps = 60/350 (17%)
Query: 107 RKKRWESEIPDKGRFSRTNIISDLEEQIS---ELTAIIEQMNRDHQSAQKLLSSEMDLRC 163
+ +RW+ + DK + + + +L+EQ+ + + + ++ H +L S+ DL
Sbjct: 662 KARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLE- 720
Query: 164 AEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMFRT 223
+ K N + K E+EL+ N+ + K Q + EM K LK
Sbjct: 721 -QTKTRHLALNLQEKSKLESELA----NFGPRINDIKRIIQSREREM----KDLKEKMNQ 771
Query: 224 YQDSIYDEMEEKWSKQKAKWKKDEKFERENILLQQKKKMTKKFEMESGEEDKKINESCSA 283
+D +++E + + + ++EK +R+N + +++ + E++K
Sbjct: 772 VEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEF----------ENQKTRLGIQL 821
Query: 284 VFENFIQEKEELLKQH------QSDTLQLEELRKTKEVPWRRDQINRHWHDVLQQLLLMQ 337
FE Q KE+ K H + D ++E+L+K ++ RH + + + +Q
Sbjct: 822 DFEK-NQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQ---------RHMKIIDETMAQLQ 871
Query: 338 VMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILT 397
+L Q L +S + + E++K K ++ H + +T
Sbjct: 872 ----DLKNQHLAKKSEVNDKNHEMEEIRK--------------KLGGANKEMTHLQKEVT 913
Query: 398 EENIHLKQKIISKNEEICEGCSGRLASITVSKDDSDTV--QDGSKKGQES 445
L+QK S + + C + + +SK D + ++GS +G++S
Sbjct: 914 AIETKLEQK-RSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDS 962
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 55.5 bits (132), Expect = 1e-07
Identities = 66/326 (20%), Positives = 143/326 (43%), Gaps = 25/326 (7%)
Query: 127 ISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELS 186
I ++E + +++ D ++ K + E+ ++K + E LKE H+ EL
Sbjct: 812 IQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEIT---LKEKHQKELL 868
Query: 187 ELENNYKAALKA---EKLAAQEKLEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQKAKW 243
L+N Y+ L E + K++++ E L+ + + + EK + +
Sbjct: 869 SLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQN 928
Query: 244 KKDEK-FERENILLQQ-----KKKMTKKFEMESGEEDKKINESCSAVFENFIQEKEELLK 297
+KD+K E ENI+ Q + K +++ +E ++ N+ + +Q E+
Sbjct: 929 EKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHL 988
Query: 298 QHQSDTLQLEELRKTKEVPWRR----DQINRHWHDVLQQLL-----LMQVMQEELHAQAL 348
+ DTLQ+ +++ ++V +++ + ++ Q+ ++Q +++L L
Sbjct: 989 KELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKL 1048
Query: 349 ILESLNTNLYYTQLELQKEKAIVGNLEKMLQTKFAETEEKYKHTIQILTE----ENIHLK 404
+ L+ ++EL ++A ++ +L+ A+ +E K ++ TE E L
Sbjct: 1049 KVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLN 1108
Query: 405 QKIISKNEEICEGCSGRLASITVSKD 430
QKI NE G + +T+ KD
Sbjct: 1109 QKIQDNNENYQVGLAELRTLMTIEKD 1134
Score = 48.9 bits (115), Expect = 9e-06
Identities = 80/371 (21%), Positives = 156/371 (42%), Gaps = 71/371 (19%)
Query: 103 EMFDRKKRWESEIPD--KGRFSRTNIISDLEEQISELTAIIEQMNRD------HQSAQKL 154
E+ K +E ++ K N I L+ ++ L +++ + + + A
Sbjct: 866 ELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVIC 925
Query: 155 LSSEMDLRCAEMKQNFENKNRELKEAHEAELSELENNYKAALKAEKLAAQEKLEEMGKEY 214
L +E D + EM+ ++N E+KE ++ LE+ K ++ ++ + E E
Sbjct: 926 LQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQ 985
Query: 215 KYLKNMFRTYQDSIYDEMEEKWSKQKAKWKKDEKFERENI---------LLQQKKKMTK- 264
+LK + T Q E E+ + + ++ +K ++ I ++Q+K+K +
Sbjct: 986 SHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQE 1045
Query: 265 -------------KFEMESGEEDKKINESCSAVFENFIQEKEEL--LKQHQSDTLQLE-- 307
K E+E ++ + +E + E+ Q+KE L L + +++ L+ E
Sbjct: 1046 LKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEIS 1105
Query: 308 ------------------ELRKTKEVPWRRDQ-----INRHWHDVLQQLLLMQVMQ-EEL 343
ELR + +DQ I+RH + +L ++ + L
Sbjct: 1106 KLNQKIQDNNENYQVGLAELRTLMTI--EKDQCISELISRHEEE--SNILKAELNKVTSL 1161
Query: 344 HAQALILESLNTNLYYTQLELQ-KEKAIVGNLEKMLQTKFAETEEKYKHTIQILTEENIH 402
H QA +E NL +ELQ K + + LE+ K + EEKY+ IQ L ++
Sbjct: 1162 HNQAFEIEK---NLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKD--- 1215
Query: 403 LKQKIISKNEE 413
+QK++S E+
Sbjct: 1216 -RQKLVSSQEQ 1225
Score = 42.0 bits (97), Expect = 0.001
Identities = 68/290 (23%), Positives = 125/290 (43%), Gaps = 72/290 (24%)
Query: 67 SARQEETNKSFYEVINVSPGYQLVRNREQISVTLGDEMFDRKKRWESEIPDKGRFSRTNI 126
S +EE+N E+ V+ L +I L +++ + + + +SE+ R I
Sbjct: 1142 SRHEEESNILKAELNKVT---SLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKI 1198
Query: 127 ISDLEEQISELTAIIEQMNRDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAELS 186
+Q + AII+ + +D Q KL+SS+ R +Q + N E EA
Sbjct: 1199 T----QQEEKYEAIIQNLEKDRQ---KLVSSQEQDR----EQLIQKLNCEKDEA------ 1241
Query: 187 ELENNYKAALKAEKLAAQEKLEEMGKEYKYLKNMF---------RTYQDSIYDEMEEKWS 237
+ ALK KL + +E+ ++ K+L+N R S+ E++EK
Sbjct: 1242 -----IQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQ 1296
Query: 238 KQKAKW---------KKDEKFE--RENILLQQ---------KKKMTK-----------KF 266
++KAK+ +K+E+ + R +++ +Q ++KM K K
Sbjct: 1297 EEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKS 1356
Query: 267 EMESGEEDKKINESCSAVFENFIQEKEELLKQHQSDTLQLEELRKTKEVP 316
M+ E DK + ES S ++EK++L + ++ +LR + VP
Sbjct: 1357 TMQQQERDKDLIESLSEDRARLLEEKKKLEE-------EVSKLRSSSFVP 1399
Score = 41.6 bits (96), Expect = 0.001
Identities = 70/338 (20%), Positives = 141/338 (41%), Gaps = 57/338 (16%)
Query: 128 SDLEEQISELTAIIEQMN---RDHQSAQKLLSSEMDLRCAEMKQNFENKNRELKEAHEAE 184
++ ++++ E+ I+ N ++ + +++++ ++ E + + EL+ ++
Sbjct: 928 NEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSH 987
Query: 185 LSELENNYKAA--LKAEKLAAQEK--LEEMGKEYKYLKNMFRTYQDSIYDEMEEKWSKQK 240
L ELE+ + + EK+ + LEE+ KE + + N + I E E++ + K
Sbjct: 988 LKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELK 1047
Query: 241 AKWK---------------KDEKFERENILL-----QQKKKMTKKFEMESGE---EDKKI 277
K K+ + + ILL QQK+ + E E+ E K+
Sbjct: 1048 LKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKL 1107
Query: 278 NESCSAVFENF------------IQEKE---ELLKQHQSDTLQLE-ELRKTKEVPWRRDQ 321
N+ EN+ I++ + EL+ +H+ ++ L+ EL K + + +
Sbjct: 1108 NQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFE 1167
Query: 322 INRHWHDVLQQLLLMQVMQEELHAQALILESLNTNLYYTQLELQKEKAIVGNLEKMLQTK 381
I ++ + + +L Q +L ++ LE Q E K +AI+ NLEK Q
Sbjct: 1168 IEKNLKEQIIEL------QSKLDSELSALERQKDEKITQQEE--KYEAIIQNLEKDRQKL 1219
Query: 382 FAETEEKYKHTIQILT---EENIHLKQKIISKNEEICE 416
+ E+ + IQ L +E I K E+ E
Sbjct: 1220 VSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVE 1257
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,751,851
Number of Sequences: 37866
Number of extensions: 794344
Number of successful extensions: 6621
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 139
Number of HSP's successfully gapped in prelim test: 793
Number of HSP's that attempted gapping in prelim test: 3932
Number of HSP's gapped (non-prelim): 2205
length of query: 445
length of database: 18,247,518
effective HSP length: 105
effective length of query: 340
effective length of database: 14,271,588
effective search space: 4852339920
effective search space used: 4852339920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.