Search of human proteins with 188219549

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|188219549 ankyrin repeat domain 32 [Homo sapiens]
         (1058 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|188219549 ankyrin repeat domain 32 [Homo sapiens]                 2133   0.0  
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                   101   3e-21
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]         97   1e-19
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]         97   1e-19
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]        94   7e-19
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]             92   3e-18
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]        92   3e-18
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]        92   3e-18
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]        92   3e-18
gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo sapi...    79   3e-14
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    74   6e-13
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    72   2e-12
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ...    70   1e-11
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        70   1e-11
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         70   1e-11
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         70   1e-11
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ...    69   2e-11
gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens]    68   5e-11
gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens]    68   5e-11
gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens]    68   5e-11
gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens]     68   5e-11
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        66   2e-10
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         66   2e-10
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         66   2e-10
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         66   2e-10
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         66   2e-10
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                     65   3e-10
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         64   1e-09
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]       63   2e-09
gi|18079216 CASK interacting protein 1 [Homo sapiens]                  62   2e-09

>gi|188219549 ankyrin repeat domain 32 [Homo sapiens]
          Length = 1058

 Score = 2133 bits (5528), Expect = 0.0
 Identities = 1058/1058 (100%), Positives = 1058/1058 (100%)

Query: 1    MEDGTPKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAA 60
            MEDGTPKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAA
Sbjct: 1    MEDGTPKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAA 60

Query: 61   CAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQSAPKRWREELKRTGA 120
            CAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQSAPKRWREELKRTGA
Sbjct: 61   CAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQSAPKRWREELKRTGA 120

Query: 121  PGAFHRWKVVLLVRTDKRSDSLIRVLEAGKANVILPKSSPSGITHVIASNARIKAEKEKD 180
            PGAFHRWKVVLLVRTDKRSDSLIRVLEAGKANVILPKSSPSGITHVIASNARIKAEKEKD
Sbjct: 121  PGAFHRWKVVLLVRTDKRSDSLIRVLEAGKANVILPKSSPSGITHVIASNARIKAEKEKD 180

Query: 181  NFKAPFYPIQYLGDFLLEKEIQNDEDSQTNSVWTEHSNEETNKDFRKDAGFLEMKGALRE 240
            NFKAPFYPIQYLGDFLLEKEIQNDEDSQTNSVWTEHSNEETNKDFRKDAGFLEMKGALRE
Sbjct: 181  NFKAPFYPIQYLGDFLLEKEIQNDEDSQTNSVWTEHSNEETNKDFRKDAGFLEMKGALRE 240

Query: 241  TMYRTQKEMQNHEDVNVGSILIQHHKKEKFSGSSKDLKFVKMRNTFGSHTYENQKEIKKK 300
            TMYRTQKEMQNHEDVNVGSILIQHHKKEKFSGSSKDLKFVKMRNTFGSHTYENQKEIKKK
Sbjct: 241  TMYRTQKEMQNHEDVNVGSILIQHHKKEKFSGSSKDLKFVKMRNTFGSHTYENQKEIKKK 300

Query: 301  DEDIQRSYTLRRKRKKGKESNCKKGVEHEKIKSTLRRHIYNRDQKEMKNSIFAEYAKESK 360
            DEDIQRSYTLRRKRKKGKESNCKKGVEHEKIKSTLRRHIYNRDQKEMKNSIFAEYAKESK
Sbjct: 301  DEDIQRSYTLRRKRKKGKESNCKKGVEHEKIKSTLRRHIYNRDQKEMKNSIFAEYAKESK 360

Query: 361  AMAIKTDVDVVEIKNTLRKHIYRAQAVRYNCIRIDKQPVYNVEVKNAEFPRGVLNLIESL 420
            AMAIKTDVDVVEIKNTLRKHIYRAQAVRYNCIRIDKQPVYNVEVKNAEFPRGVLNLIESL
Sbjct: 361  AMAIKTDVDVVEIKNTLRKHIYRAQAVRYNCIRIDKQPVYNVEVKNAEFPRGVLNLIESL 420

Query: 421  IEGHFFKEAIEELSTLQAHYIPPVCVLHALLENVLQDNIDTFSGRYFHILSALLHLHPPW 480
            IEGHFFKEAIEELSTLQAHYIPPVCVLHALLENVLQDNIDTFSGRYFHILSALLHLHPPW
Sbjct: 421  IEGHFFKEAIEELSTLQAHYIPPVCVLHALLENVLQDNIDTFSGRYFHILSALLHLHPPW 480

Query: 481  KSPAMSRYYLELFQCPTCMKGAWSLVEVLIRSCLFNESFCHQISENIGSKVLHLTLLKFF 540
            KSPAMSRYYLELFQCPTCMKGAWSLVEVLIRSCLFNESFCHQISENIGSKVLHLTLLKFF
Sbjct: 481  KSPAMSRYYLELFQCPTCMKGAWSLVEVLIRSCLFNESFCHQISENIGSKVLHLTLLKFF 540

Query: 541  FNLIESEVQHLSQKLYDWSDSQNLKITGKAMLLEIFWSGSETSGLLTKPVNMLLEWTIYS 600
            FNLIESEVQHLSQKLYDWSDSQNLKITGKAMLLEIFWSGSETSGLLTKPVNMLLEWTIYS
Sbjct: 541  FNLIESEVQHLSQKLYDWSDSQNLKITGKAMLLEIFWSGSETSGLLTKPVNMLLEWTIYS 600

Query: 601  HKEKFKSNDVFKHELAYLLAGILGAAIDYWIFLGLKMGRNVMRHMSDDLGSYVSLSCDDF 660
            HKEKFKSNDVFKHELAYLLAGILGAAIDYWIFLGLKMGRNVMRHMSDDLGSYVSLSCDDF
Sbjct: 601  HKEKFKSNDVFKHELAYLLAGILGAAIDYWIFLGLKMGRNVMRHMSDDLGSYVSLSCDDF 660

Query: 661  SSQELEIFICSFSSSWLQMFVAEAVFKKLCLQSSGSVSSEPLSLQKMVYSYLPALGKTGV 720
            SSQELEIFICSFSSSWLQMFVAEAVFKKLCLQSSGSVSSEPLSLQKMVYSYLPALGKTGV
Sbjct: 661  SSQELEIFICSFSSSWLQMFVAEAVFKKLCLQSSGSVSSEPLSLQKMVYSYLPALGKTGV 720

Query: 721  LGSGKIQVSKKIGQRPCFDSQRTLLMLNGTKQKQVEGLPELLDLNLAKCSSSLKKLKKKS 780
            LGSGKIQVSKKIGQRPCFDSQRTLLMLNGTKQKQVEGLPELLDLNLAKCSSSLKKLKKKS
Sbjct: 721  LGSGKIQVSKKIGQRPCFDSQRTLLMLNGTKQKQVEGLPELLDLNLAKCSSSLKKLKKKS 780

Query: 781  EGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNA 840
            EGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNA
Sbjct: 781  EGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNA 840

Query: 841  GWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGP 900
            GWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGP
Sbjct: 841  GWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGP 900

Query: 901  VLLQQRNAKGELPLDYVVSPQIKEELFAITKIEDTVENFHAQAEKHFHYQQLEFGSFLLS 960
            VLLQQRNAKGELPLDYVVSPQIKEELFAITKIEDTVENFHAQAEKHFHYQQLEFGSFLLS
Sbjct: 901  VLLQQRNAKGELPLDYVVSPQIKEELFAITKIEDTVENFHAQAEKHFHYQQLEFGSFLLS 960

Query: 961  RMLLNFCSIFDLSSEFILASKGLTHLNELLMACKSHKETTSVHTDWLLDLYAGNIKTLQK 1020
            RMLLNFCSIFDLSSEFILASKGLTHLNELLMACKSHKETTSVHTDWLLDLYAGNIKTLQK
Sbjct: 961  RMLLNFCSIFDLSSEFILASKGLTHLNELLMACKSHKETTSVHTDWLLDLYAGNIKTLQK 1020

Query: 1021 LPHILKELPENLKVCPGVHTEALMITLEMMCRSVMEFS 1058
            LPHILKELPENLKVCPGVHTEALMITLEMMCRSVMEFS
Sbjct: 1021 LPHILKELPENLKVCPGVHTEALMITLEMMCRSVMEFS 1058


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score =  101 bits (252), Expect = 3e-21
 Identities = 63/136 (46%), Positives = 79/136 (58%), Gaps = 5/136 (3%)

Query: 786 CSKENCPSVVK-KMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTP 844
           C K    S  K K   +K N +GET LHRA I     ++  L+S  G D+NVKD AGWT 
Sbjct: 146 CQKGTPNSASKTKDKVNKRNERGETRLHRAAIRGDARRIKELIS-EGADVNVKDFAGWTA 204

Query: 845 LHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQ 904
           LHEACN G     +++L    EV+    +D  TPLHDA +NGH ++ KLLL++GG    Q
Sbjct: 205 LHEACNRGYYDVAKQLLAAGAEVN-TKGLDDDTPLHDAANNGHYKVVKLLLRYGGNP--Q 261

Query: 905 QRNAKGELPLDYVVSP 920
           Q N KGE PL    SP
Sbjct: 262 QSNRKGETPLKVANSP 277



 Score = 33.9 bits (76), Expect = 0.83
 Identities = 32/169 (18%), Positives = 76/169 (44%), Gaps = 29/169 (17%)

Query: 201 IQNDEDSQTNSVWTEHSNEETNKDFRKDAGFLEMKGALRETMYRTQKEMQNHEDVNVGSI 260
           ++ND  ++      +H  +     F+K+    +MK   +E +++ +K ++  +D N    
Sbjct: 674 LENDLSTENKLKVLKHDRDH----FKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDIS 729

Query: 261 LIQHHKKEKFSGSSKDLKFVKMRNTFGSHTYENQKEIKKKDEDIQRSYTLRRKRKKGKES 320
                +K++ + + K+                + KE   K+E ++     R+K+ K + S
Sbjct: 730 RSFREEKDRSNKAEKE---------------RSLKEKSPKEEKLRLYKEERKKKSKDRPS 774

Query: 321 NCKK--GVEHEKIKSTLRRHIYNRDQKEMK-------NSIFAEYAKESK 360
             +K   ++ +KI S  +  I+  D++++K       +S F EY  +++
Sbjct: 775 KLEKKNDLKEDKI-SKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQ 822


>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
          Length = 2039

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 60/145 (41%), Positives = 86/145 (59%), Gaps = 6/145 (4%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           +K   +K N +GET LH A I   V+++  L+SL G ++NVKD AGWTPLHEACN G   
Sbjct: 151 QKDKVNKRNERGETPLHMAAIRGDVKQVKELISL-GANVNVKDFAGWTPLHEACNVGYYD 209

Query: 856 CVQEILQRCPEVDLLTQ-VDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
             + ++      D+ TQ +D  TPLHD+ S+GH +I KLLL+HGG     Q N  GE P+
Sbjct: 210 VAKILI--AAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPF--QANKHGERPV 265

Query: 915 DYVVSPQIKEELFAITKIEDTVENF 939
           D   + +++  L     + D  E++
Sbjct: 266 DVAETEELELLLKREVPLSDDDESY 290


>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
          Length = 2062

 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 60/145 (41%), Positives = 86/145 (59%), Gaps = 6/145 (4%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           +K   +K N +GET LH A I   V+++  L+SL G ++NVKD AGWTPLHEACN G   
Sbjct: 174 QKDKVNKRNERGETPLHMAAIRGDVKQVKELISL-GANVNVKDFAGWTPLHEACNVGYYD 232

Query: 856 CVQEILQRCPEVDLLTQ-VDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
             + ++      D+ TQ +D  TPLHD+ S+GH +I KLLL+HGG     Q N  GE P+
Sbjct: 233 VAKILI--AAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPF--QANKHGERPV 288

Query: 915 DYVVSPQIKEELFAITKIEDTVENF 939
           D   + +++  L     + D  E++
Sbjct: 289 DVAETEELELLLKREVPLSDDDESY 313


>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
          Length = 1378

 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 54/122 (44%), Positives = 74/122 (60%), Gaps = 5/122 (4%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K   +++ N  GET LHRACI  Q+ ++  L+   G  +N +D  GWTPLHEACNYG+  
Sbjct: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVR-QGHPLNPRDYCGWTPLHEACNYGHLE 576

Query: 856 CVQEILQRCPEVDLL--TQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELP 913
            V+ +L     VD       +G+TPLHDAL+ GH E+ +LLL+ G  V L+ R  KG  P
Sbjct: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTR--KGLSP 634

Query: 914 LD 915
           L+
Sbjct: 635 LE 636


>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
          Length = 777

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 60/137 (43%), Positives = 75/137 (54%), Gaps = 10/137 (7%)

Query: 802 KTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEIL 861
           K N +GET LH A I   +  +  LL   G D NVKD+AGWTPLHEACN+G+   V+ +L
Sbjct: 423 KRNHRGETLLHIASIKGDIPSVEYLLQ-NGSDPNVKDHAGWTPLHEACNHGHLKVVELLL 481

Query: 862 QRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAK---GELPLDYVV 918
           Q    V+  T     +PLHDA  NGHV+I KLLL +G       RNA    G  P+DY  
Sbjct: 482 QHKALVN-TTGYQNDSPLHDAAKNGHVDIVKLLLSYGA-----SRNAVNIFGLRPVDYTD 535

Query: 919 SPQIKEELFAITKIEDT 935
              +K  L    K E +
Sbjct: 536 DESMKSLLLLPEKNESS 552


>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
          Length = 1873

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 57/169 (33%), Positives = 95/169 (56%), Gaps = 9/169 (5%)

Query: 765  NLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLI 824
            N++K  +++ KL ++ + E+S         +K    +K N +GE+ LH A     +  L+
Sbjct: 1118 NMSKELANISKLSQREKKEISHKPG-----MKAGRINKRNARGESQLHLAVRRGNLP-LV 1171

Query: 825  LLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALS 884
              L   G D+N+ DNAGWTPLHEA N G+   + E+L+   +V+    +DG+ PLHDA++
Sbjct: 1172 KALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVN-CENIDGILPLHDAVA 1230

Query: 885  NGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEELFAITKIE 933
            N H++  ++LLQ+G      Q++ K +  LD     ++KE L +   IE
Sbjct: 1231 NNHLKAAEILLQNGANP--NQKDQKQKSALDEADDEKMKELLRSYGAIE 1277



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 41/124 (33%), Positives = 67/124 (54%), Gaps = 7/124 (5%)

Query: 795 VKKMNFH---KTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNY 851
           V K++ H   + N+ GE  +++A +++  + L+      G ++N    AGWT LHEA   
Sbjct: 474 VNKISLHSINRRNIFGENLVYKAALHDDAD-LVHHCIKKGGNVNQPSYAGWTALHEASVG 532

Query: 852 GNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGE 911
           G      E+L+   +V++      +TPLHDA+ NGH ++ +LLL +G   L   RN  G+
Sbjct: 533 GFYRTASELLKGGADVNIKGLYQ-ITPLHDAVMNGHYKVAELLLLNGADPLF--RNDDGK 589

Query: 912 LPLD 915
             LD
Sbjct: 590 CALD 593


>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
          Length = 1873

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 57/169 (33%), Positives = 95/169 (56%), Gaps = 9/169 (5%)

Query: 765  NLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLI 824
            N++K  +++ KL ++ + E+S         +K    +K N +GE+ LH A     +  L+
Sbjct: 1118 NMSKELANISKLSQREKKEISHKPG-----MKAGRINKRNARGESQLHLAVRRGNLP-LV 1171

Query: 825  LLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALS 884
              L   G D+N+ DNAGWTPLHEA N G+   + E+L+   +V+    +DG+ PLHDA++
Sbjct: 1172 KALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVN-CENIDGILPLHDAVA 1230

Query: 885  NGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEELFAITKIE 933
            N H++  ++LLQ+G      Q++ K +  LD     ++KE L +   IE
Sbjct: 1231 NNHLKAAEILLQNGANP--NQKDQKQKSALDEADDEKMKELLRSYGAIE 1277



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 41/124 (33%), Positives = 67/124 (54%), Gaps = 7/124 (5%)

Query: 795 VKKMNFH---KTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNY 851
           V K++ H   + N+ GE  +++A +++  + L+      G ++N    AGWT LHEA   
Sbjct: 474 VNKISLHSINRRNIFGENLVYKAALHDDAD-LVHHCIKKGGNVNQPSYAGWTALHEASVG 532

Query: 852 GNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGE 911
           G      E+L+   +V++      +TPLHDA+ NGH ++ +LLL +G   L   RN  G+
Sbjct: 533 GFYRTASELLKGGADVNIKGLYQ-ITPLHDAVMNGHYKVAELLLLNGADPLF--RNDDGK 589

Query: 912 LPLD 915
             LD
Sbjct: 590 CALD 593


>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
          Length = 1873

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 57/169 (33%), Positives = 95/169 (56%), Gaps = 9/169 (5%)

Query: 765  NLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLI 824
            N++K  +++ KL ++ + E+S         +K    +K N +GE+ LH A     +  L+
Sbjct: 1118 NMSKELANISKLSQREKKEISHKPG-----MKAGRINKRNARGESQLHLAVRRGNLP-LV 1171

Query: 825  LLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALS 884
              L   G D+N+ DNAGWTPLHEA N G+   + E+L+   +V+    +DG+ PLHDA++
Sbjct: 1172 KALIESGADVNLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVN-CENIDGILPLHDAVA 1230

Query: 885  NGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEELFAITKIE 933
            N H++  ++LLQ+G      Q++ K +  LD     ++KE L +   IE
Sbjct: 1231 NNHLKAAEILLQNGANP--NQKDQKQKSALDEADDEKMKELLRSYGAIE 1277



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 41/124 (33%), Positives = 67/124 (54%), Gaps = 7/124 (5%)

Query: 795 VKKMNFH---KTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNY 851
           V K++ H   + N+ GE  +++A +++  + L+      G ++N    AGWT LHEA   
Sbjct: 474 VNKISLHSINRRNIFGENLVYKAALHDDAD-LVHHCIKKGGNVNQPSYAGWTALHEASVG 532

Query: 852 GNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGE 911
           G      E+L+   +V++      +TPLHDA+ NGH ++ +LLL +G   L   RN  G+
Sbjct: 533 GFYRTASELLKGGADVNIKGLYQ-ITPLHDAVMNGHYKVAELLLLNGADPLF--RNDDGK 589

Query: 912 LPLD 915
             LD
Sbjct: 590 CALD 593


>gi|194440660 topoisomerase (DNA) II binding protein 1 [Homo sapiens]
          Length = 1522

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 57/216 (26%), Positives = 102/216 (47%), Gaps = 19/216 (8%)

Query: 2    EDGTPKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYK-NCTHLIAERLCKSEKFLAA 60
            E+   ++I Q++    +E+     L+ KL    I+ + +   CTH++     ++EK+LA+
Sbjct: 1262 EELKKQYIFQLSSLNPQERIDYCHLIEKLGGLVIEKQCFDPTCTHIVVGHPLRNEKYLAS 1321

Query: 61   CAAGKWILTKDYIIHSAKSGRWLDETTYEWGYKIEKDSRYSPQMQS-----APKRWREEL 115
             AAGKW+L + Y+     +G ++ E  YEWG     D      +Q      A  RWR+++
Sbjct: 1322 VAAGKWVLHRSYLEACRTAGHFVQEEDYEWGSSSILDVLTGINVQQRRLALAAMRWRKKI 1381

Query: 116  KRTG----APGAFHRWKVVLLVRTDKRSDSLIRVLEAGKANVILPKSSP--SGITHVIAS 169
            ++        GAF  WKV+L V    R     R+L++G A V+   S P     TH+ + 
Sbjct: 1382 QQRQESGIVEGAFSGWKVILHV-DQSREAGFKRLLQSGGAKVLPGHSVPLFKEATHLFSD 1440

Query: 170  NARIKAEKEKDNF------KAPFYPIQYLGDFLLEK 199
              ++K +    N              +Y+ D+L+++
Sbjct: 1441 LNKLKPDDSGVNIAEAAAQNVYCLRTEYIADYLMQE 1476


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 55/164 (33%), Positives = 82/164 (50%), Gaps = 8/164 (4%)

Query: 756 EGLPELLD--LNLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHR 813
           E + +LL   ++L    +  + L+    G++   K+ C   V+ +N      +  T LH 
Sbjct: 475 ENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC--TVQSVNCRDIEGRQSTPLHF 532

Query: 814 ACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQV 873
           A   N+V  +  LL   G D++ KD  G  PLH AC+YG+   V E+L +   V  +  +
Sbjct: 533 AAGYNRVSVVEYLLQ-HGADVHAKDKGGLVPLHNACSYGHYE-VAELLVKHGAVVNVADL 590

Query: 874 DGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYV 917
              TPLH+A + G  EI KLLLQHG      ++N  G  PLD V
Sbjct: 591 WKFTPLHEAAAKGKYEICKLLLQHGADP--TKKNRDGNTPLDLV 632



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 45/130 (34%), Positives = 70/130 (53%), Gaps = 6/130 (4%)

Query: 798 MNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCV 857
           +N H ++ +  T LH A   N+V K++ LL   G D++ KD     PLH AC+YG+    
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRV-KIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVT 260

Query: 858 QEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGG-PVLLQQRNAKGELPLDY 916
           + +++    V+ +  +   TPLH+A S   VE+  LLL +G  P LL   N   +  +D 
Sbjct: 261 ELLVKHGACVNAM-DLWQFTPLHEAASKNRVEVCSLLLSYGADPTLL---NCHNKSAIDL 316

Query: 917 VVSPQIKEEL 926
             +PQ+KE L
Sbjct: 317 APTPQLKERL 326



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 52/164 (31%), Positives = 76/164 (46%), Gaps = 10/164 (6%)

Query: 771 SSLKKLKKKSEGELSCSKENCPSVVKKM------NFHKTNLKGETALHRACINNQVEKLI 824
           + ++ L +     L  +K+ C + VKK+      N   T  +  T LH A   N +E   
Sbjct: 637 TDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAE 696

Query: 825 LLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALS 884
            LL   G D+N +D  G  PLH A +YG+ V V  +L +       T     TPLH+A  
Sbjct: 697 YLLQ-HGADVNAQDKGGLIPLHNAASYGH-VDVAALLIKYNACVNATDKWAFTPLHEAAQ 754

Query: 885 NGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEELFA 928
            G  ++  LLL HG    L  +N +G+ PLD V +  +   L A
Sbjct: 755 KGRTQLCALLLAHGADPTL--KNQEGQTPLDLVSADDVSALLTA 796



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 42/150 (28%), Positives = 73/150 (48%), Gaps = 5/150 (3%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           +K+N   T  +  T LH A    + + +  LL   G ++  +D+ G  PLH AC++G+  
Sbjct: 47  EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQ-NGANVQARDDGGLIPLHNACSFGHAE 105

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLD 915
            V  +L+   + +     +  TPLH+A   G +++  +LLQHG    +  RN  G   LD
Sbjct: 106 VVNLLLRHGADPNARDNWN-YTPLHEAAIKGKIDVCIVLLQHGAEPTI--RNTDGRTALD 162

Query: 916 YVVSPQIKEELFAITKIEDTVENFHAQAEK 945
            +  P  K  L    K ++ +E+  +  E+
Sbjct: 163 -LADPSAKAVLTGEYKKDELLESARSGNEE 191



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 35/90 (38%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 811 LHRACINNQVEKLILLLSLPGIDINVKDNAGW--TPLHEACNYGNTVCVQEILQRCPEVD 868
           L  AC N  VE++  L++     +N +D AG   TPLH A  +G    V+ +LQ    V 
Sbjct: 28  LFEACRNGDVERVKRLVTPE--KVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQ 85

Query: 869 LLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
                 G+ PLH+A S GH E+  LLL+HG
Sbjct: 86  ARDD-GGLIPLHNACSFGHAEVVNLLLRHG 114



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 34/96 (35%), Positives = 51/96 (53%), Gaps = 2/96 (2%)

Query: 806 KGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCP 865
           K +  L  A   N+ EK++ LL+   ++ +  D    TPLH A  Y     VQ +LQ   
Sbjct: 177 KKDELLESARSGNE-EKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGA 235

Query: 866 EVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPV 901
           +V    + D + PLH+A S GH E+ +LL++HG  V
Sbjct: 236 DVHAKDKGD-LVPLHNACSYGHYEVTELLVKHGACV 270



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 8/127 (6%)

Query: 779 KSEGELSCSKENCPSVVKK-MNFHKTNLKG----ETALHRACINNQVEK--LILLLSLPG 831
           K    L  ++E   + +KK ++    N K     ETALH A  +   ++  +  LL   G
Sbjct: 331 KGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKG 390

Query: 832 IDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIG 891
            +IN K     TPLH A    +   V+ +++   +V+ L  + G T LH A   GH++  
Sbjct: 391 ANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNL-GQTSLHRAAYCGHLQTC 449

Query: 892 KLLLQHG 898
           +LLL +G
Sbjct: 450 RLLLSYG 456


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 45/130 (34%), Positives = 72/130 (55%), Gaps = 6/130 (4%)

Query: 798 MNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCV 857
           +N H ++ +  T LH A   N+V +++ LL   G D++ KD  G  PLH AC+YG+    
Sbjct: 360 VNCHASDGRKSTPLHLAAGYNRV-RIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVT 418

Query: 858 QEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGG-PVLLQQRNAKGELPLDY 916
           + +L+    V+ +  +   TPLH+A S   VE+  LLL HG  P L+   N  G+  +D 
Sbjct: 419 ELLLKHGACVNAM-DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLV---NCHGKSAVDM 474

Query: 917 VVSPQIKEEL 926
             +P+++E L
Sbjct: 475 APTPELRERL 484



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 58/184 (31%), Positives = 90/184 (48%), Gaps = 10/184 (5%)

Query: 738 FDSQRTLLMLNGTKQKQV--EGLPELLDLNLAKCSSSL--KKLKKKSEGELSCSKENCPS 793
           + S  +++ L G    Q+  E + ++L  +    +S +  + L+    G+L   K+ C S
Sbjct: 613 YGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSS 672

Query: 794 VVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGN 853
             + +N      +  T LH A   N+V  +  LL   G D++ KD  G  PLH AC+YG+
Sbjct: 673 --QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH-HGADVHAKDKGGLVPLHNACSYGH 729

Query: 854 TVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELP 913
              V E+L R      +  +   TPLH+A + G  EI KLLL+HG      ++N  G  P
Sbjct: 730 YE-VAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADP--TKKNRDGNTP 786

Query: 914 LDYV 917
           LD V
Sbjct: 787 LDLV 790



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 61/209 (29%), Positives = 94/209 (44%), Gaps = 16/209 (7%)

Query: 744 LLMLNG---TKQKQVEGLPELLDLNLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKM-- 798
           LL+ +G   TK+ +    P  LDL + +  + ++ L +     L  +K+ C + V+K+  
Sbjct: 768 LLLKHGADPTKKNRDGNTP--LDL-VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCT 824

Query: 799 ----NFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNT 854
               N   T  +  T LH A   N +E    LL   G D+N +D  G  PLH A +YG+ 
Sbjct: 825 PENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLE-HGADVNAQDKGGLIPLHNAASYGH- 882

Query: 855 VCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           V +  +L +       T     TPLH+A   G  ++  LLL HG    +  +N +G+ PL
Sbjct: 883 VDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM--KNQEGQTPL 940

Query: 915 DYVVSPQIKEELFAITKIEDTVENFHAQA 943
           D   +  I+  L      E     F  QA
Sbjct: 941 DLATADDIRALLIDAMPPEALPTCFKPQA 969



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 34/91 (37%), Positives = 48/91 (52%), Gaps = 1/91 (1%)

Query: 811 LHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLL 870
           L  A  +   EKL+ LL+   ++ +  D    TPLH A  Y     VQ +LQ   +V   
Sbjct: 339 LLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398

Query: 871 TQVDGVTPLHDALSNGHVEIGKLLLQHGGPV 901
            +  G+ PLH+A S GH E+ +LLL+HG  V
Sbjct: 399 DK-GGLVPLHNACSYGHYEVTELLLKHGACV 428



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 34/108 (31%), Positives = 56/108 (51%), Gaps = 6/108 (5%)

Query: 831 GIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVD-GVTPLHDALSNGHVE 889
           G +++ +D+ G  PLH AC++G+   V  +L  C   D   + +   TPLH+A   G ++
Sbjct: 239 GANVHARDDGGLIPLHNACSFGHAEVVSLLL--CQGADPNARDNWNYTPLHEAAIKGKID 296

Query: 890 IGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEELFAITKIEDTVE 937
           +  +LLQHG    +  RN  G+  LD +  P  K  L    K ++ +E
Sbjct: 297 VCIVLLQHGADPNI--RNTDGKSALD-LADPSAKAVLTGEYKKDELLE 341



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 33/90 (36%), Positives = 45/90 (50%), Gaps = 5/90 (5%)

Query: 811 LHRACINNQVEKLILLLSLPGIDINVKDNAGW--TPLHEACNYGNTVCVQEILQRCPEVD 868
           L  AC N  V ++  L+     ++N KD AG   +PLH A  +G    V+ +LQ    V 
Sbjct: 186 LLEACRNGDVSRVKRLVD--AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 243

Query: 869 LLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
                 G+ PLH+A S GH E+  LLL  G
Sbjct: 244 ARDD-GGLIPLHNACSFGHAEVVSLLLCQG 272



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 25/60 (41%), Positives = 30/60 (50%), Gaps = 2/60 (3%)

Query: 799 NFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGN-TVCV 857
           N H  +  G   LH AC     E + LLL   G D N +DN  +TPLHEA   G   VC+
Sbjct: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLC-QGADPNARDNWNYTPLHEAAIKGKIDVCI 299



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 37/128 (28%), Positives = 63/128 (49%), Gaps = 10/128 (7%)

Query: 779 KSEGELSCSKENCPSVVKK------MNFHKTNLKGETALHRAC--INNQVEKLILLLSLP 830
           K    L  ++E   + VKK      +NF K     ETALH A   ++ + +++  LL   
Sbjct: 489 KGHSLLQAAREADLAKVKKTLALEIINF-KQPQSHETALHCAVASLHPKRKQVTELLLRK 547

Query: 831 GIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEI 890
           G ++N K+    TPLH A    +   ++ + +   +++ L  + G T LH A   GH++ 
Sbjct: 548 GANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL-GQTALHRAALAGHLQT 606

Query: 891 GKLLLQHG 898
            +LLL +G
Sbjct: 607 CRLLLSYG 614


>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
           sapiens]
          Length = 226

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 57/179 (31%), Positives = 85/179 (47%), Gaps = 18/179 (10%)

Query: 769 CSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLS 828
           C S+L        G+L   KE+   +  K    +T+    TALH AC     E +  LL 
Sbjct: 4   CVSNLMVCNLAYSGKLEELKESI--LADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61

Query: 829 LPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHV 888
           L G+ +N KD+AGW+PLH A + G    V+ +L +  +V+ + Q +G TPLH A S    
Sbjct: 62  L-GVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQ-NGCTPLHYAASKNRH 119

Query: 889 EIGKLLLQHGG---------PVLLQQRNAKGELPLDYVVSPQIKEELFAITKIEDTVEN 938
           EI  +LL+ G             + +  AKG L + +++         A T I+DT  N
Sbjct: 120 EIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILL-----YYKASTNIQDTEGN 173



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 2/117 (1%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K    +  N  G T LH A   N+ E  ++LL   G + + KD+   T +H A   GN  
Sbjct: 95  KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE-GGANPDAKDHYEATAMHRAAAKGNLK 153

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGEL 912
            +  +L      ++    +G TPLH A     VE  KLL+  G  + ++ +  K  L
Sbjct: 154 MIHILLYYKASTNI-QDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPL 209


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 45/119 (37%), Positives = 64/119 (53%), Gaps = 2/119 (1%)

Query: 794 VVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGN 853
           V  KM  ++T   G T LH A     V    LLL+  G  ++     G TPLH A   GN
Sbjct: 199 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGN 257

Query: 854 TVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGEL 912
           T  V+ +L R  ++D  T+ DG+TPLH A  +GH ++ +LLL+ G P+L + +N    L
Sbjct: 258 TNMVKLLLDRGGQIDAKTR-DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 315



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 39/103 (37%), Positives = 56/103 (54%), Gaps = 2/103 (1%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K  N H +   G T+LH A   ++V  +  +L+  G D +     G+TPL  AC+YGN  
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVN-VADILTKHGADQDAHTKLGYTPLIVACHYGNVK 721

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V  +L++   V+  T+ +G TPLH A   GH  I  +LLQHG
Sbjct: 722 MVNFLLKQGANVNAKTK-NGYTPLHQAAQQGHTHIINVLLQHG 763



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 43/112 (38%), Positives = 57/112 (50%), Gaps = 4/112 (3%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           TN++GETALH A    QVE +  LL   G  ++ +     TPLH A   G T  VQ +LQ
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLR-NGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 497

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
                D  T  +G TPLH +   G V++  +LL+ G    L  +  KG  PL
Sbjct: 498 HMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPL 546



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 40/119 (33%), Positives = 60/119 (50%), Gaps = 4/119 (3%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K+ N +   L G T LH AC  N+++ + LL+   G  I     +G TP+H A   G+  
Sbjct: 366 KRANPNARALNGFTPLHIACKKNRIKVMELLVKY-GASIQAITESGLTPIHVAAFMGHLN 424

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
            V  +LQ     D+ T + G T LH A   G VE+ + LL++G   L+  R  + + PL
Sbjct: 425 IVLLLLQNGASPDV-TNIRGETALHMAARAGQVEVVRCLLRNG--ALVDARAREEQTPL 480



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 43/132 (32%), Positives = 62/132 (46%), Gaps = 12/132 (9%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           T   G T LH A        + LLL   G  I+ K   G TPLH A   G+   V+ +L+
Sbjct: 241 TARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLE 299

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQI 922
           R   +   T+ +G++PLH A    HVE  K LLQH  PV         ++ LDY+ +  +
Sbjct: 300 RGAPLLARTK-NGLSPLHMAAQGDHVECVKHLLQHKAPV--------DDVTLDYLTALHV 350

Query: 923 KEEL--FAITKI 932
                 + +TK+
Sbjct: 351 AAHCGHYRVTKL 362



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 60/254 (23%), Positives = 106/254 (41%), Gaps = 20/254 (7%)

Query: 749 GTKQKQVEGLPELLDLNLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGE 808
           G   K VE L   +D+N    +          EG +   +E    + +  +      KG 
Sbjct: 21  GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE---LLGRGSSVDSATKKGN 77

Query: 809 TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVD 868
           TALH A +  Q E ++ +L   G +IN +   G+TPL+ A    +   V+ +L+      
Sbjct: 78  TALHIASLAGQAE-VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 136

Query: 869 LLTQVDGVTPLHDALSNGHVEIGKLLLQHG--GPVLL--------QQRNAKGELPLDYVV 918
             T+ DG TPL  AL  GH +   +LL++   G V L        +       L L    
Sbjct: 137 TATE-DGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH 195

Query: 919 SPQIKEELFAITKIEDTVENFHAQAEKHFHYQQLEFGSFLLSR-MLLNFCSIFDLSSEFI 977
           +  ++ ++      E      H  A    HY  +   + LL+R   ++F +   ++   +
Sbjct: 196 NADVQSKMMVNRTTESGFTPLHIAA----HYGNVNVATLLLNRGAAVDFTARNGITPLHV 251

Query: 978 LASKGLTHLNELLM 991
            + +G T++ +LL+
Sbjct: 252 ASKRGNTNMVKLLL 265



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 33/98 (33%), Positives = 48/98 (48%), Gaps = 2/98 (2%)

Query: 801 HKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           H T   G T LH A   NQ++    LL+  G + N+    G TPLH A   G+T  V  +
Sbjct: 602 HATAKNGYTPLHIAAKKNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLL 660

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           L +   + + T+  G+T LH A     V +  +L +HG
Sbjct: 661 LDKGANIHMSTK-SGLTSLHLAAQEDKVNVADILTKHG 697



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 34/95 (35%), Positives = 48/95 (50%), Gaps = 2/95 (2%)

Query: 813 RACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQ 872
           RA     ++K++  L   GIDIN  +  G   LH A   G+   VQE+L R   VD  T+
Sbjct: 16  RAARAGNLDKVVEYLK-GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74

Query: 873 VDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRN 907
             G T LH A   G  E+ K+L++ G  +  Q +N
Sbjct: 75  -KGNTALHIASLAGQAEVVKVLVKEGANINAQSQN 108



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 20/156 (12%)

Query: 766 LAKCSSSLKKLKKKSEGE-LSCSKENCPSVVKKMNFHKTNLKGETALHRA--CINNQVEK 822
           LA+  + L  L   ++G+ + C K     +  K       L   TALH A  C + +V K
Sbjct: 305 LARTKNGLSPLHMAAQGDHVECVKH---LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 361

Query: 823 LILLLSLPGIDINVKDNA----GWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTP 878
           L+L       D     NA    G+TPLH AC       ++ +++    +  +T+  G+TP
Sbjct: 362 LLL-------DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE-SGLTP 413

Query: 879 LHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           +H A   GH+ I  LLLQ+G        N +GE  L
Sbjct: 414 IHVAAFMGHLNIVLLLLQNGASP--DVTNIRGETAL 447



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 2/108 (1%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A   +  +K+ LLL   G   +     G+TPLH A           +L    E
Sbjct: 575 GLTPLHVAAHYDN-QKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 633

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
            +++T+  GVTPLH A   GH ++  LLL  G  + +  ++    L L
Sbjct: 634 TNIVTK-QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 680



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 2/92 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH +    QV+   +LL   G   ++    G+TPLH A  YG+    + +LQR   
Sbjct: 509 GYTPLHISAREGQVDVASVLLEA-GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 567

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            D   + +G+TPLH A    + ++  LLL+ G
Sbjct: 568 ADSAGK-NGLTPLHVAAHYDNQKVALLLLEKG 598



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T L  AC    V K++  L   G ++N K   G+TPLH+A   G+T  +  +LQ   +
Sbjct: 707 GYTPLIVACHYGNV-KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765

Query: 867 VDLLTQVDGVTPLHDALSNGHVEI 890
            +  T  +G T L  A   G++ +
Sbjct: 766 PN-ATTANGNTALAIAKRLGYISV 788


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 45/119 (37%), Positives = 64/119 (53%), Gaps = 2/119 (1%)

Query: 794 VVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGN 853
           V  KM  ++T   G T LH A     V    LLL+  G  ++     G TPLH A   GN
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGN 278

Query: 854 TVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGEL 912
           T  V+ +L R  ++D  T+ DG+TPLH A  +GH ++ +LLL+ G P+L + +N    L
Sbjct: 279 TNMVKLLLDRGGQIDAKTR-DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 39/103 (37%), Positives = 56/103 (54%), Gaps = 2/103 (1%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K  N H +   G T+LH A   ++V  +  +L+  G D +     G+TPL  AC+YGN  
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVN-VADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V  +L++   V+  T+ +G TPLH A   GH  I  +LLQHG
Sbjct: 743 MVNFLLKQGANVNAKTK-NGYTPLHQAAQQGHTHIINVLLQHG 784



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 43/112 (38%), Positives = 57/112 (50%), Gaps = 4/112 (3%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           TN++GETALH A    QVE +  LL   G  ++ +     TPLH A   G T  VQ +LQ
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLR-NGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
                D  T  +G TPLH +   G V++  +LL+ G    L  +  KG  PL
Sbjct: 519 HMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPL 567



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 40/119 (33%), Positives = 60/119 (50%), Gaps = 4/119 (3%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K+ N +   L G T LH AC  N+++ + LL+   G  I     +G TP+H A   G+  
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKY-GASIQAITESGLTPIHVAAFMGHLN 445

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
            V  +LQ     D+ T + G T LH A   G VE+ + LL++G   L+  R  + + PL
Sbjct: 446 IVLLLLQNGASPDV-TNIRGETALHMAARAGQVEVVRCLLRNG--ALVDARAREEQTPL 501



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 43/132 (32%), Positives = 62/132 (46%), Gaps = 12/132 (9%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           T   G T LH A        + LLL   G  I+ K   G TPLH A   G+   V+ +L+
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLE 320

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQI 922
           R   +   T+ +G++PLH A    HVE  K LLQH  PV         ++ LDY+ +  +
Sbjct: 321 RGAPLLARTK-NGLSPLHMAAQGDHVECVKHLLQHKAPV--------DDVTLDYLTALHV 371

Query: 923 KEEL--FAITKI 932
                 + +TK+
Sbjct: 372 AAHCGHYRVTKL 383



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 60/254 (23%), Positives = 106/254 (41%), Gaps = 20/254 (7%)

Query: 749 GTKQKQVEGLPELLDLNLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGE 808
           G   K VE L   +D+N    +          EG +   +E    + +  +      KG 
Sbjct: 42  GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE---LLGRGSSVDSATKKGN 98

Query: 809 TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVD 868
           TALH A +  Q E ++ +L   G +IN +   G+TPL+ A    +   V+ +L+      
Sbjct: 99  TALHIASLAGQAE-VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 869 LLTQVDGVTPLHDALSNGHVEIGKLLLQHG--GPVLL--------QQRNAKGELPLDYVV 918
             T+ DG TPL  AL  GH +   +LL++   G V L        +       L L    
Sbjct: 158 TATE-DGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH 216

Query: 919 SPQIKEELFAITKIEDTVENFHAQAEKHFHYQQLEFGSFLLSR-MLLNFCSIFDLSSEFI 977
           +  ++ ++      E      H  A    HY  +   + LL+R   ++F +   ++   +
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAA----HYGNVNVATLLLNRGAAVDFTARNGITPLHV 272

Query: 978 LASKGLTHLNELLM 991
            + +G T++ +LL+
Sbjct: 273 ASKRGNTNMVKLLL 286



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 33/98 (33%), Positives = 48/98 (48%), Gaps = 2/98 (2%)

Query: 801 HKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           H T   G T LH A   NQ++    LL+  G + N+    G TPLH A   G+T  V  +
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLL 681

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           L +   + + T+  G+T LH A     V +  +L +HG
Sbjct: 682 LDKGANIHMSTK-SGLTSLHLAAQEDKVNVADILTKHG 718



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 34/95 (35%), Positives = 48/95 (50%), Gaps = 2/95 (2%)

Query: 813 RACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQ 872
           RA     ++K++  L   GIDIN  +  G   LH A   G+   VQE+L R   VD  T+
Sbjct: 37  RAARAGNLDKVVEYLK-GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95

Query: 873 VDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRN 907
             G T LH A   G  E+ K+L++ G  +  Q +N
Sbjct: 96  -KGNTALHIASLAGQAEVVKVLVKEGANINAQSQN 129



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 20/156 (12%)

Query: 766 LAKCSSSLKKLKKKSEGE-LSCSKENCPSVVKKMNFHKTNLKGETALHRA--CINNQVEK 822
           LA+  + L  L   ++G+ + C K     +  K       L   TALH A  C + +V K
Sbjct: 326 LARTKNGLSPLHMAAQGDHVECVKH---LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 382

Query: 823 LILLLSLPGIDINVKDNA----GWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTP 878
           L+L       D     NA    G+TPLH AC       ++ +++    +  +T+  G+TP
Sbjct: 383 LLL-------DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE-SGLTP 434

Query: 879 LHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           +H A   GH+ I  LLLQ+G        N +GE  L
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASP--DVTNIRGETAL 468



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 2/108 (1%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A   +  +K+ LLL   G   +     G+TPLH A           +L    E
Sbjct: 596 GLTPLHVAAHYDN-QKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
            +++T+  GVTPLH A   GH ++  LLL  G  + +  ++    L L
Sbjct: 655 TNIVTK-QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 2/92 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH +    QV+   +LL   G   ++    G+TPLH A  YG+    + +LQR   
Sbjct: 530 GYTPLHISAREGQVDVASVLLEA-GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            D   + +G+TPLH A    + ++  LLL+ G
Sbjct: 589 ADSAGK-NGLTPLHVAAHYDNQKVALLLLEKG 619



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 38/137 (27%), Positives = 62/137 (45%), Gaps = 10/137 (7%)

Query: 770 SSSLKKLKKKSEGELSCSKE----NCPSVVKKM----NFHKTNLKGETALHRACINNQVE 821
           SS  +K  KKS+   S  +     N   VV+ +    + +  N  G  ALH A     V 
Sbjct: 19  SSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVG 78

Query: 822 KLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHD 881
            +  LL   G  ++     G T LH A   G    V+ +++    ++  +Q +G TPL+ 
Sbjct: 79  LVQELLGR-GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ-NGFTPLYM 136

Query: 882 ALSNGHVEIGKLLLQHG 898
           A    H+++ K LL++G
Sbjct: 137 AAQENHIDVVKYLLENG 153



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T L  AC    V K++  L   G ++N K   G+TPLH+A   G+T  +  +LQ   +
Sbjct: 728 GYTPLIVACHYGNV-KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786

Query: 867 VDLLTQVDGVTPLHDALSNGHVEI 890
            +  T  +G T L  A   G++ +
Sbjct: 787 PN-ATTANGNTALAIAKRLGYISV 809


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 45/119 (37%), Positives = 64/119 (53%), Gaps = 2/119 (1%)

Query: 794 VVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGN 853
           V  KM  ++T   G T LH A     V    LLL+  G  ++     G TPLH A   GN
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR-GAAVDFTARNGITPLHVASKRGN 278

Query: 854 TVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGEL 912
           T  V+ +L R  ++D  T+ DG+TPLH A  +GH ++ +LLL+ G P+L + +N    L
Sbjct: 279 TNMVKLLLDRGGQIDAKTR-DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPL 336



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 39/103 (37%), Positives = 56/103 (54%), Gaps = 2/103 (1%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K  N H +   G T+LH A   ++V  +  +L+  G D +     G+TPL  AC+YGN  
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVN-VADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V  +L++   V+  T+ +G TPLH A   GH  I  +LLQHG
Sbjct: 743 MVNFLLKQGANVNAKTK-NGYTPLHQAAQQGHTHIINVLLQHG 784



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 43/112 (38%), Positives = 57/112 (50%), Gaps = 4/112 (3%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           TN++GETALH A    QVE +  LL   G  ++ +     TPLH A   G T  VQ +LQ
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLR-NGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
                D  T  +G TPLH +   G V++  +LL+ G    L  +  KG  PL
Sbjct: 519 HMAHPDAAT-TNGYTPLHISAREGQVDVASVLLEAGAAHSLATK--KGFTPL 567



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 40/119 (33%), Positives = 60/119 (50%), Gaps = 4/119 (3%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K+ N +   L G T LH AC  N+++ + LL+   G  I     +G TP+H A   G+  
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKY-GASIQAITESGLTPIHVAAFMGHLN 445

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
            V  +LQ     D+ T + G T LH A   G VE+ + LL++G   L+  R  + + PL
Sbjct: 446 IVLLLLQNGASPDV-TNIRGETALHMAARAGQVEVVRCLLRNG--ALVDARAREEQTPL 501



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 43/132 (32%), Positives = 62/132 (46%), Gaps = 12/132 (9%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           T   G T LH A        + LLL   G  I+ K   G TPLH A   G+   V+ +L+
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGG-QIDAKTRDGLTPLHCAARSGHDQVVELLLE 320

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQI 922
           R   +   T+ +G++PLH A    HVE  K LLQH  PV         ++ LDY+ +  +
Sbjct: 321 RGAPLLARTK-NGLSPLHMAAQGDHVECVKHLLQHKAPV--------DDVTLDYLTALHV 371

Query: 923 KEEL--FAITKI 932
                 + +TK+
Sbjct: 372 AAHCGHYRVTKL 383



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 60/254 (23%), Positives = 106/254 (41%), Gaps = 20/254 (7%)

Query: 749 GTKQKQVEGLPELLDLNLAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGE 808
           G   K VE L   +D+N    +          EG +   +E    + +  +      KG 
Sbjct: 42  GNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE---LLGRGSSVDSATKKGN 98

Query: 809 TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVD 868
           TALH A +  Q E ++ +L   G +IN +   G+TPL+ A    +   V+ +L+      
Sbjct: 99  TALHIASLAGQAE-VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQS 157

Query: 869 LLTQVDGVTPLHDALSNGHVEIGKLLLQHG--GPVLL--------QQRNAKGELPLDYVV 918
             T+ DG TPL  AL  GH +   +LL++   G V L        +       L L    
Sbjct: 158 TATE-DGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH 216

Query: 919 SPQIKEELFAITKIEDTVENFHAQAEKHFHYQQLEFGSFLLSR-MLLNFCSIFDLSSEFI 977
           +  ++ ++      E      H  A    HY  +   + LL+R   ++F +   ++   +
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAA----HYGNVNVATLLLNRGAAVDFTARNGITPLHV 272

Query: 978 LASKGLTHLNELLM 991
            + +G T++ +LL+
Sbjct: 273 ASKRGNTNMVKLLL 286



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 33/98 (33%), Positives = 48/98 (48%), Gaps = 2/98 (2%)

Query: 801 HKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           H T   G T LH A   NQ++    LL+  G + N+    G TPLH A   G+T  V  +
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNY-GAETNIVTKQGVTPLHLASQEGHTDMVTLL 681

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           L +   + + T+  G+T LH A     V +  +L +HG
Sbjct: 682 LDKGANIHMSTK-SGLTSLHLAAQEDKVNVADILTKHG 718



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 34/95 (35%), Positives = 48/95 (50%), Gaps = 2/95 (2%)

Query: 813 RACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQ 872
           RA     ++K++  L   GIDIN  +  G   LH A   G+   VQE+L R   VD  T+
Sbjct: 37  RAARAGNLDKVVEYLK-GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95

Query: 873 VDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRN 907
             G T LH A   G  E+ K+L++ G  +  Q +N
Sbjct: 96  -KGNTALHIASLAGQAEVVKVLVKEGANINAQSQN 129



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 47/156 (30%), Positives = 71/156 (45%), Gaps = 20/156 (12%)

Query: 766 LAKCSSSLKKLKKKSEGE-LSCSKENCPSVVKKMNFHKTNLKGETALHRA--CINNQVEK 822
           LA+  + L  L   ++G+ + C K     +  K       L   TALH A  C + +V K
Sbjct: 326 LARTKNGLSPLHMAAQGDHVECVKH---LLQHKAPVDDVTLDYLTALHVAAHCGHYRVTK 382

Query: 823 LILLLSLPGIDINVKDNA----GWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTP 878
           L+L       D     NA    G+TPLH AC       ++ +++    +  +T+  G+TP
Sbjct: 383 LLL-------DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE-SGLTP 434

Query: 879 LHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           +H A   GH+ I  LLLQ+G        N +GE  L
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASP--DVTNIRGETAL 468



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 2/108 (1%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A   +  +K+ LLL   G   +     G+TPLH A           +L    E
Sbjct: 596 GLTPLHVAAHYDN-QKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
            +++T+  GVTPLH A   GH ++  LLL  G  + +  ++    L L
Sbjct: 655 TNIVTK-QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 701



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 2/92 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH +    QV+   +LL   G   ++    G+TPLH A  YG+    + +LQR   
Sbjct: 530 GYTPLHISAREGQVDVASVLLEA-GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAA 588

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            D   + +G+TPLH A    + ++  LLL+ G
Sbjct: 589 ADSAGK-NGLTPLHVAAHYDNQKVALLLLEKG 619



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 38/137 (27%), Positives = 62/137 (45%), Gaps = 10/137 (7%)

Query: 770 SSSLKKLKKKSEGELSCSKE----NCPSVVKKM----NFHKTNLKGETALHRACINNQVE 821
           SS  +K  KKS+   S  +     N   VV+ +    + +  N  G  ALH A     V 
Sbjct: 19  SSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVG 78

Query: 822 KLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHD 881
            +  LL   G  ++     G T LH A   G    V+ +++    ++  +Q +G TPL+ 
Sbjct: 79  LVQELLGR-GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ-NGFTPLYM 136

Query: 882 ALSNGHVEIGKLLLQHG 898
           A    H+++ K LL++G
Sbjct: 137 AAQENHIDVVKYLLENG 153



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 2/84 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T L  AC    V K++  L   G ++N K   G+TPLH+A   G+T  +  +LQ   +
Sbjct: 728 GYTPLIVACHYGNV-KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786

Query: 867 VDLLTQVDGVTPLHDALSNGHVEI 890
            +  T  +G T L  A   G++ +
Sbjct: 787 PN-ATTANGNTALAIAKRLGYISV 809


>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
           sapiens]
          Length = 151

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 47/130 (36%), Positives = 68/130 (52%), Gaps = 4/130 (3%)

Query: 769 CSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLS 828
           C S+L        G+L   KE+   +  K    +T+    TALH AC     E +  LL 
Sbjct: 4   CVSNLMVCNLAYSGKLEELKESI--LADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61

Query: 829 LPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHV 888
           L G+ +N KD+AGW+PLH A + G    V+ +L +  +V+ + Q +G TPLH A S    
Sbjct: 62  L-GVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQ-NGCTPLHYAASKNRH 119

Query: 889 EIGKLLLQHG 898
           EI  +LL+ G
Sbjct: 120 EIAVMLLEGG 129



 Score = 31.2 bits (69), Expect = 5.4
 Identities = 21/49 (42%), Positives = 24/49 (48%), Gaps = 2/49 (4%)

Query: 871 TQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVS 919
           T  D  T LH A S GH EI + LLQ G PV    ++  G  PL    S
Sbjct: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPV--NDKDDAGWSPLHIAAS 82


>gi|183396783 BCL-6 interacting corepressor isoform a [Homo sapiens]
          Length = 1721

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 39/92 (42%), Positives = 53/92 (57%), Gaps = 1/92 (1%)

Query: 807  GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
            GET L RA      E ++  L     D+N +DNAG+  LHEAC  G    V+ +L+   +
Sbjct: 1429 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1488

Query: 867  VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V+   Q DG  PLHDA+ N H+EI +LLL +G
Sbjct: 1489 VNCSAQ-DGTRPLHDAVENDHLEIVRLLLSYG 1519


>gi|183396787 BCL-6 interacting corepressor isoform c [Homo sapiens]
          Length = 1755

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 39/92 (42%), Positives = 53/92 (57%), Gaps = 1/92 (1%)

Query: 807  GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
            GET L RA      E ++  L     D+N +DNAG+  LHEAC  G    V+ +L+   +
Sbjct: 1463 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1522

Query: 867  VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V+   Q DG  PLHDA+ N H+EI +LLL +G
Sbjct: 1523 VNCSAQ-DGTRPLHDAVENDHLEIVRLLLSYG 1553


>gi|183396785 BCL-6 interacting corepressor isoform b [Homo sapiens]
          Length = 1703

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 39/92 (42%), Positives = 53/92 (57%), Gaps = 1/92 (1%)

Query: 807  GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
            GET L RA      E ++  L     D+N +DNAG+  LHEAC  G    V+ +L+   +
Sbjct: 1411 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1470

Query: 867  VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V+   Q DG  PLHDA+ N H+EI +LLL +G
Sbjct: 1471 VNCSAQ-DGTRPLHDAVENDHLEIVRLLLSYG 1501


>gi|21071037 BCL-6 interacting corepressor isoform a [Homo sapiens]
          Length = 1721

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 39/92 (42%), Positives = 53/92 (57%), Gaps = 1/92 (1%)

Query: 807  GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
            GET L RA      E ++  L     D+N +DNAG+  LHEAC  G    V+ +L+   +
Sbjct: 1429 GETLLQRAARLGYEEVVLYCLENKICDVNHRDNAGYCALHEACARGWLNIVRHLLEYGAD 1488

Query: 867  VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V+   Q DG  PLHDA+ N H+EI +LLL +G
Sbjct: 1489 VNCSAQ-DGTRPLHDAVENDHLEIVRLLLSYG 1519


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 39/101 (38%), Positives = 55/101 (54%), Gaps = 2/101 (1%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A     +    LLL+  G  +N     G TPLH A   GN + V+ +L R  +
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRN 907
           ++  T+ D +TPLH A  NGHV I ++LL HG P+  + +N
Sbjct: 298 IETKTK-DELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/103 (34%), Positives = 55/103 (53%), Gaps = 2/103 (1%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K+ N +  N  G T LH       V    +L+   G+ ++     G+TPLH A +YGN  
Sbjct: 690 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIK 748

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V+ +LQ   +V+  T++ G +PLH A   GH +I  LLL++G
Sbjct: 749 LVKFLLQHQADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNG 790



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 39/97 (40%), Positives = 50/97 (51%), Gaps = 2/97 (2%)

Query: 805 LKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRC 864
           L G T LH AC  N V  + LLL   G  I+    +G TPLH A   G+   V+ +LQR 
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 460

Query: 865 PEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPV 901
              ++ + V   TPLH A   GH E+ K LLQ+   V
Sbjct: 461 ASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKV 496



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 39/114 (34%), Positives = 52/114 (45%), Gaps = 4/114 (3%)

Query: 801 HKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           H     G T LH A   NQVE    LL   G   N +   G TPLH A   G+   V  +
Sbjct: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEGHAEMVALL 687

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           L +    +L  +  G+TPLH     GHV +  +L++HG  V++      G  PL
Sbjct: 688 LSKQANGNLGNK-SGLTPLHLVAQEGHVPVADVLIKHG--VMVDATTRMGYTPL 738



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 56/222 (25%), Positives = 94/222 (42%), Gaps = 25/222 (11%)

Query: 796  KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
            K++    T  KG TALH A +  Q E +  L++  G ++N +   G+TPL+ A    +  
Sbjct: 100  KEIILETTTKKGNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQENHLE 158

Query: 856  CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLD 915
             V+ +L+     ++ T+ DG TPL  AL  GH  +   L+ +G          K  LP  
Sbjct: 159  VVKFLLENGANQNVATE-DGFTPLAVALQQGHENVVAHLINYG-------TKGKVRLPAL 210

Query: 916  YVVSPQIKEELFAITKIEDTVENFHAQAEKHF-------HYQQLEFGSFLLSR-MLLNFC 967
            ++ +        A+    D   N    ++  F       HY+ L     LL+R   +NF 
Sbjct: 211  HIAARNDDTRTAAVLLQND--PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268

Query: 968  SIFDLSSEFILASKGLTHLNELLM------ACKSHKETTSVH 1003
                ++   I + +G   +  LL+        K+  E T +H
Sbjct: 269  PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 310



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 37/98 (37%), Positives = 50/98 (51%), Gaps = 3/98 (3%)

Query: 802 KTNLKGE-TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           +T  K E T LH A  N  V    +LL   G  I  K   G +P+H A    +  CV+ +
Sbjct: 299 ETKTKDELTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 357

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           LQ   E+D +T +D +TPLH A   GH  + K+LL  G
Sbjct: 358 LQYDAEIDDIT-LDHLTPLHVAAHCGHHRVAKVLLDKG 394



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 7/109 (6%)

Query: 804 NLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQR 863
           +++G T LH A      E + LLLS    + N+ + +G TPLH     G+      +++ 
Sbjct: 665 SVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723

Query: 864 CPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGEL 912
              VD  T++ G TPLH A   G++++ K LLQH   V     NAK +L
Sbjct: 724 GVMVDATTRM-GYTPLHVASHYGNIKLVKFLLQHQADV-----NAKTKL 766



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 39/108 (36%), Positives = 57/108 (52%), Gaps = 8/108 (7%)

Query: 809 TALHRA--CINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           T LH A  C +++V K++L     G   N +   G+TPLH AC   +   ++ +L+    
Sbjct: 373 TPLHVAAHCGHHRVAKVLLD---KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           +D +T+  G+TPLH A   GH+ I K LLQ G    +   N K E PL
Sbjct: 430 IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPL 474



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 35/94 (37%), Positives = 44/94 (46%), Gaps = 2/94 (2%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           +N+K ET LH A      E    LL      +N K     TPLH A   G+T  V+ +L+
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQ 896
                +L T   G TPLH A   GHVE    LL+
Sbjct: 525 NNANPNLATTA-GHTPLHIAAREGHVETVLALLE 557



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 47/153 (30%), Positives = 69/153 (45%), Gaps = 9/153 (5%)

Query: 766 LAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLK---GETALHRACINNQVEK 822
           +A+ +  LKK+K      L   KE   S  K+ N  +   K     T+  RA  +  ++K
Sbjct: 1   MAQAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDK 60

Query: 823 LILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDL-LTQVDGVTPLHD 881
            +  L   G+DIN  +  G   LH A   G+   V E+L +  E+ L  T   G T LH 
Sbjct: 61  ALDHLR-NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHI 117

Query: 882 ALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           A   G  E+ + L+ +G  V  Q +  KG  PL
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQ--KGFTPL 148



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 37/109 (33%), Positives = 48/109 (44%), Gaps = 4/109 (3%)

Query: 806 KGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCP 865
           KG T LH A    +V    LLL       N     G TPLH A ++ N   V+ +L R  
Sbjct: 568 KGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626

Query: 866 EVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
                   +G TPLH A     VE+ + LLQ+GG       + +G  PL
Sbjct: 627 SPHSPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPL 672



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 33/89 (37%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A  +N ++ + LLL   G   +   N G+TPLH A         + +LQ    
Sbjct: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGS 660

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLL 895
            +    V GVTPLH A   GH E+  LLL
Sbjct: 661 ANA-ESVQGVTPLHLAAQEGHAEMVALLL 688



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 2/101 (1%)

Query: 798 MNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCV 857
           ++ +  N  G   LH A     V+ ++ LL    I +      G T LH A   G    V
Sbjct: 69  VDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVV 127

Query: 858 QEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           +E++     V+  +Q  G TPL+ A    H+E+ K LL++G
Sbjct: 128 RELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENG 167


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 39/101 (38%), Positives = 55/101 (54%), Gaps = 2/101 (1%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A     +    LLL+  G  +N     G TPLH A   GN + V+ +L R  +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRN 907
           ++  T+ D +TPLH A  NGHV I ++LL HG P+  + +N
Sbjct: 265 IETKTK-DELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/103 (34%), Positives = 55/103 (53%), Gaps = 2/103 (1%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K+ N +  N  G T LH       V    +L+   G+ ++     G+TPLH A +YGN  
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V+ +LQ   +V+  T++ G +PLH A   GH +I  LLL++G
Sbjct: 716 LVKFLLQHQADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNG 757



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 39/97 (40%), Positives = 50/97 (51%), Gaps = 2/97 (2%)

Query: 805 LKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRC 864
           L G T LH AC  N V  + LLL   G  I+    +G TPLH A   G+   V+ +LQR 
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 865 PEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPV 901
              ++ + V   TPLH A   GH E+ K LLQ+   V
Sbjct: 428 ASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 39/114 (34%), Positives = 52/114 (45%), Gaps = 4/114 (3%)

Query: 801 HKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           H     G T LH A   NQVE    LL   G   N +   G TPLH A   G+   V  +
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEGHAEMVALL 654

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           L +    +L  +  G+TPLH     GHV +  +L++HG  V++      G  PL
Sbjct: 655 LSKQANGNLGNK-SGLTPLHLVAQEGHVPVADVLIKHG--VMVDATTRMGYTPL 705



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 56/222 (25%), Positives = 94/222 (42%), Gaps = 25/222 (11%)

Query: 796  KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
            K++    T  KG TALH A +  Q E +  L++  G ++N +   G+TPL+ A    +  
Sbjct: 67   KEIILETTTKKGNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQENHLE 125

Query: 856  CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLD 915
             V+ +L+     ++ T+ DG TPL  AL  GH  +   L+ +G          K  LP  
Sbjct: 126  VVKFLLENGANQNVATE-DGFTPLAVALQQGHENVVAHLINYG-------TKGKVRLPAL 177

Query: 916  YVVSPQIKEELFAITKIEDTVENFHAQAEKHF-------HYQQLEFGSFLLSR-MLLNFC 967
            ++ +        A+    D   N    ++  F       HY+ L     LL+R   +NF 
Sbjct: 178  HIAARNDDTRTAAVLLQND--PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 968  SIFDLSSEFILASKGLTHLNELLM------ACKSHKETTSVH 1003
                ++   I + +G   +  LL+        K+  E T +H
Sbjct: 236  PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 37/98 (37%), Positives = 50/98 (51%), Gaps = 3/98 (3%)

Query: 802 KTNLKGE-TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           +T  K E T LH A  N  V    +LL   G  I  K   G +P+H A    +  CV+ +
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           LQ   E+D +T +D +TPLH A   GH  + K+LL  G
Sbjct: 325 LQYDAEIDDIT-LDHLTPLHVAAHCGHHRVAKVLLDKG 361



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 7/109 (6%)

Query: 804 NLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQR 863
           +++G T LH A      E + LLLS    + N+ + +G TPLH     G+      +++ 
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 864 CPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGEL 912
              VD  T++ G TPLH A   G++++ K LLQH   V     NAK +L
Sbjct: 691 GVMVDATTRM-GYTPLHVASHYGNIKLVKFLLQHQADV-----NAKTKL 733



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 39/108 (36%), Positives = 57/108 (52%), Gaps = 8/108 (7%)

Query: 809 TALHRA--CINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           T LH A  C +++V K++L     G   N +   G+TPLH AC   +   ++ +L+    
Sbjct: 340 TPLHVAAHCGHHRVAKVLLD---KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           +D +T+  G+TPLH A   GH+ I K LLQ G    +   N K E PL
Sbjct: 397 IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPL 441



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 35/94 (37%), Positives = 44/94 (46%), Gaps = 2/94 (2%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           +N+K ET LH A      E    LL      +N K     TPLH A   G+T  V+ +L+
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQ 896
                +L T   G TPLH A   GHVE    LL+
Sbjct: 492 NNANPNLATTA-GHTPLHIAAREGHVETVLALLE 524



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 37/109 (33%), Positives = 48/109 (44%), Gaps = 4/109 (3%)

Query: 806 KGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCP 865
           KG T LH A    +V    LLL       N     G TPLH A ++ N   V+ +L R  
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593

Query: 866 EVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
                   +G TPLH A     VE+ + LLQ+GG       + +G  PL
Sbjct: 594 SPHSPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPL 639



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 33/89 (37%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A  +N ++ + LLL   G   +   N G+TPLH A         + +LQ    
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLL 895
            +    V GVTPLH A   GH E+  LLL
Sbjct: 628 ANA-ESVQGVTPLHLAAQEGHAEMVALLL 655



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 2/101 (1%)

Query: 798 MNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCV 857
           ++ +  N  G   LH A     V+ ++ LL    I +      G T LH A   G    V
Sbjct: 36  VDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVV 94

Query: 858 QEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           +E++     V+  +Q  G TPL+ A    H+E+ K LL++G
Sbjct: 95  RELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENG 134



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 35/107 (32%), Positives = 51/107 (47%), Gaps = 6/107 (5%)

Query: 809 TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVD 868
           T+  RA  +  ++K +  L   G+DIN  +  G   LH A   G+   V E+L +  E+ 
Sbjct: 14  TSFLRAARSGNLDKALDHLR-NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK--EII 70

Query: 869 L-LTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           L  T   G T LH A   G  E+ + L+ +G  V  Q +  KG  PL
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQ--KGFTPL 115


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 39/101 (38%), Positives = 55/101 (54%), Gaps = 2/101 (1%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A     +    LLL+  G  +N     G TPLH A   GN + V+ +L R  +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRN 907
           ++  T+ D +TPLH A  NGHV I ++LL HG P+  + +N
Sbjct: 265 IETKTK-DELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/103 (34%), Positives = 55/103 (53%), Gaps = 2/103 (1%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K+ N +  N  G T LH       V    +L+   G+ ++     G+TPLH A +YGN  
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V+ +LQ   +V+  T++ G +PLH A   GH +I  LLL++G
Sbjct: 716 LVKFLLQHQADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNG 757



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 39/97 (40%), Positives = 50/97 (51%), Gaps = 2/97 (2%)

Query: 805 LKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRC 864
           L G T LH AC  N V  + LLL   G  I+    +G TPLH A   G+   V+ +LQR 
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 865 PEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPV 901
              ++ + V   TPLH A   GH E+ K LLQ+   V
Sbjct: 428 ASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 39/114 (34%), Positives = 52/114 (45%), Gaps = 4/114 (3%)

Query: 801 HKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           H     G T LH A   NQVE    LL   G   N +   G TPLH A   G+   V  +
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEGHAEMVALL 654

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           L +    +L  +  G+TPLH     GHV +  +L++HG  V++      G  PL
Sbjct: 655 LSKQANGNLGNK-SGLTPLHLVAQEGHVPVADVLIKHG--VMVDATTRMGYTPL 705



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 56/222 (25%), Positives = 94/222 (42%), Gaps = 25/222 (11%)

Query: 796  KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
            K++    T  KG TALH A +  Q E +  L++  G ++N +   G+TPL+ A    +  
Sbjct: 67   KEIILETTTKKGNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQENHLE 125

Query: 856  CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLD 915
             V+ +L+     ++ T+ DG TPL  AL  GH  +   L+ +G          K  LP  
Sbjct: 126  VVKFLLENGANQNVATE-DGFTPLAVALQQGHENVVAHLINYG-------TKGKVRLPAL 177

Query: 916  YVVSPQIKEELFAITKIEDTVENFHAQAEKHF-------HYQQLEFGSFLLSR-MLLNFC 967
            ++ +        A+    D   N    ++  F       HY+ L     LL+R   +NF 
Sbjct: 178  HIAARNDDTRTAAVLLQND--PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 968  SIFDLSSEFILASKGLTHLNELLM------ACKSHKETTSVH 1003
                ++   I + +G   +  LL+        K+  E T +H
Sbjct: 236  PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 37/98 (37%), Positives = 50/98 (51%), Gaps = 3/98 (3%)

Query: 802 KTNLKGE-TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           +T  K E T LH A  N  V    +LL   G  I  K   G +P+H A    +  CV+ +
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           LQ   E+D +T +D +TPLH A   GH  + K+LL  G
Sbjct: 325 LQYDAEIDDIT-LDHLTPLHVAAHCGHHRVAKVLLDKG 361



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 7/109 (6%)

Query: 804 NLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQR 863
           +++G T LH A      E + LLLS    + N+ + +G TPLH     G+      +++ 
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 864 CPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGEL 912
              VD  T++ G TPLH A   G++++ K LLQH   V     NAK +L
Sbjct: 691 GVMVDATTRM-GYTPLHVASHYGNIKLVKFLLQHQADV-----NAKTKL 733



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 39/108 (36%), Positives = 57/108 (52%), Gaps = 8/108 (7%)

Query: 809 TALHRA--CINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           T LH A  C +++V K++L     G   N +   G+TPLH AC   +   ++ +L+    
Sbjct: 340 TPLHVAAHCGHHRVAKVLLD---KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           +D +T+  G+TPLH A   GH+ I K LLQ G    +   N K E PL
Sbjct: 397 IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPL 441



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 35/94 (37%), Positives = 44/94 (46%), Gaps = 2/94 (2%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           +N+K ET LH A      E    LL      +N K     TPLH A   G+T  V+ +L+
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQ 896
                +L T   G TPLH A   GHVE    LL+
Sbjct: 492 NNANPNLATTA-GHTPLHIAAREGHVETVLALLE 524



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 37/109 (33%), Positives = 48/109 (44%), Gaps = 4/109 (3%)

Query: 806 KGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCP 865
           KG T LH A    +V    LLL       N     G TPLH A ++ N   V+ +L R  
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593

Query: 866 EVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
                   +G TPLH A     VE+ + LLQ+GG       + +G  PL
Sbjct: 594 SPHSPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPL 639



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 33/89 (37%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A  +N ++ + LLL   G   +   N G+TPLH A         + +LQ    
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLL 895
            +    V GVTPLH A   GH E+  LLL
Sbjct: 628 ANA-ESVQGVTPLHLAAQEGHAEMVALLL 655



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 2/101 (1%)

Query: 798 MNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCV 857
           ++ +  N  G   LH A     V+ ++ LL    I +      G T LH A   G    V
Sbjct: 36  VDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVV 94

Query: 858 QEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           +E++     V+  +Q  G TPL+ A    H+E+ K LL++G
Sbjct: 95  RELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENG 134



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 35/107 (32%), Positives = 51/107 (47%), Gaps = 6/107 (5%)

Query: 809 TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVD 868
           T+  RA  +  ++K +  L   G+DIN  +  G   LH A   G+   V E+L +  E+ 
Sbjct: 14  TSFLRAARSGNLDKALDHLR-NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK--EII 70

Query: 869 L-LTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           L  T   G T LH A   G  E+ + L+ +G  V  Q +  KG  PL
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQ--KGFTPL 115


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 39/101 (38%), Positives = 55/101 (54%), Gaps = 2/101 (1%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A     +    LLL+  G  +N     G TPLH A   GN + V+ +L R  +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRN 907
           ++  T+ D +TPLH A  NGHV I ++LL HG P+  + +N
Sbjct: 265 IETKTK-DELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/103 (34%), Positives = 55/103 (53%), Gaps = 2/103 (1%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K+ N +  N  G T LH       V    +L+   G+ ++     G+TPLH A +YGN  
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V+ +LQ   +V+  T++ G +PLH A   GH +I  LLL++G
Sbjct: 716 LVKFLLQHQADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNG 757



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 39/97 (40%), Positives = 50/97 (51%), Gaps = 2/97 (2%)

Query: 805 LKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRC 864
           L G T LH AC  N V  + LLL   G  I+    +G TPLH A   G+   V+ +LQR 
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 865 PEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPV 901
              ++ + V   TPLH A   GH E+ K LLQ+   V
Sbjct: 428 ASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 39/114 (34%), Positives = 52/114 (45%), Gaps = 4/114 (3%)

Query: 801 HKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           H     G T LH A   NQVE    LL   G   N +   G TPLH A   G+   V  +
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEGHAEMVALL 654

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           L +    +L  +  G+TPLH     GHV +  +L++HG  V++      G  PL
Sbjct: 655 LSKQANGNLGNK-SGLTPLHLVAQEGHVPVADVLIKHG--VMVDATTRMGYTPL 705



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 56/222 (25%), Positives = 94/222 (42%), Gaps = 25/222 (11%)

Query: 796  KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
            K++    T  KG TALH A +  Q E +  L++  G ++N +   G+TPL+ A    +  
Sbjct: 67   KEIILETTTKKGNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQENHLE 125

Query: 856  CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLD 915
             V+ +L+     ++ T+ DG TPL  AL  GH  +   L+ +G          K  LP  
Sbjct: 126  VVKFLLENGANQNVATE-DGFTPLAVALQQGHENVVAHLINYG-------TKGKVRLPAL 177

Query: 916  YVVSPQIKEELFAITKIEDTVENFHAQAEKHF-------HYQQLEFGSFLLSR-MLLNFC 967
            ++ +        A+    D   N    ++  F       HY+ L     LL+R   +NF 
Sbjct: 178  HIAARNDDTRTAAVLLQND--PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 968  SIFDLSSEFILASKGLTHLNELLM------ACKSHKETTSVH 1003
                ++   I + +G   +  LL+        K+  E T +H
Sbjct: 236  PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 37/98 (37%), Positives = 50/98 (51%), Gaps = 3/98 (3%)

Query: 802 KTNLKGE-TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           +T  K E T LH A  N  V    +LL   G  I  K   G +P+H A    +  CV+ +
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           LQ   E+D +T +D +TPLH A   GH  + K+LL  G
Sbjct: 325 LQYDAEIDDIT-LDHLTPLHVAAHCGHHRVAKVLLDKG 361



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 7/109 (6%)

Query: 804 NLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQR 863
           +++G T LH A      E + LLLS    + N+ + +G TPLH     G+      +++ 
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 864 CPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGEL 912
              VD  T++ G TPLH A   G++++ K LLQH   V     NAK +L
Sbjct: 691 GVMVDATTRM-GYTPLHVASHYGNIKLVKFLLQHQADV-----NAKTKL 733



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 39/108 (36%), Positives = 57/108 (52%), Gaps = 8/108 (7%)

Query: 809 TALHRA--CINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           T LH A  C +++V K++L     G   N +   G+TPLH AC   +   ++ +L+    
Sbjct: 340 TPLHVAAHCGHHRVAKVLLD---KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           +D +T+  G+TPLH A   GH+ I K LLQ G    +   N K E PL
Sbjct: 397 IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPL 441



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 35/94 (37%), Positives = 44/94 (46%), Gaps = 2/94 (2%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           +N+K ET LH A      E    LL      +N K     TPLH A   G+T  V+ +L+
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQ 896
                +L T   G TPLH A   GHVE    LL+
Sbjct: 492 NNANPNLATTA-GHTPLHIAAREGHVETVLALLE 524



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 37/109 (33%), Positives = 48/109 (44%), Gaps = 4/109 (3%)

Query: 806 KGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCP 865
           KG T LH A    +V    LLL       N     G TPLH A ++ N   V+ +L R  
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593

Query: 866 EVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
                   +G TPLH A     VE+ + LLQ+GG       + +G  PL
Sbjct: 594 SPHSPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPL 639



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 33/89 (37%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A  +N ++ + LLL   G   +   N G+TPLH A         + +LQ    
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLL 895
            +    V GVTPLH A   GH E+  LLL
Sbjct: 628 ANA-ESVQGVTPLHLAAQEGHAEMVALLL 655



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 2/101 (1%)

Query: 798 MNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCV 857
           ++ +  N  G   LH A     V+ ++ LL    I +      G T LH A   G    V
Sbjct: 36  VDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVV 94

Query: 858 QEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           +E++     V+  +Q  G TPL+ A    H+E+ K LL++G
Sbjct: 95  RELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENG 134



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 35/107 (32%), Positives = 51/107 (47%), Gaps = 6/107 (5%)

Query: 809 TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVD 868
           T+  RA  +  ++K +  L   G+DIN  +  G   LH A   G+   V E+L +  E+ 
Sbjct: 14  TSFLRAARSGNLDKALDHLR-NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK--EII 70

Query: 869 L-LTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           L  T   G T LH A   G  E+ + L+ +G  V  Q +  KG  PL
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQ--KGFTPL 115


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 39/101 (38%), Positives = 55/101 (54%), Gaps = 2/101 (1%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A     +    LLL+  G  +N     G TPLH A   GN + V+ +L R  +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRN 907
           ++  T+ D +TPLH A  NGHV I ++LL HG P+  + +N
Sbjct: 265 IETKTK-DELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/103 (34%), Positives = 55/103 (53%), Gaps = 2/103 (1%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           K+ N +  N  G T LH       V    +L+   G+ ++     G+TPLH A +YGN  
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK-HGVMVDATTRMGYTPLHVASHYGNIK 715

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
            V+ +LQ   +V+  T++ G +PLH A   GH +I  LLL++G
Sbjct: 716 LVKFLLQHQADVNAKTKL-GYSPLHQAAQQGHTDIVTLLLKNG 757



 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 39/97 (40%), Positives = 50/97 (51%), Gaps = 2/97 (2%)

Query: 805 LKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRC 864
           L G T LH AC  N V  + LLL   G  I+    +G TPLH A   G+   V+ +LQR 
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKT-GASIDAVTESGLTPLHVASFMGHLPIVKNLLQRG 427

Query: 865 PEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPV 901
              ++ + V   TPLH A   GH E+ K LLQ+   V
Sbjct: 428 ASPNV-SNVKVETPLHMAARAGHTEVAKYLLQNKAKV 463



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 39/114 (34%), Positives = 52/114 (45%), Gaps = 4/114 (3%)

Query: 801 HKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           H     G T LH A   NQVE    LL   G   N +   G TPLH A   G+   V  +
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGG-SANAESVQGVTPLHLAAQEGHAEMVALL 654

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           L +    +L  +  G+TPLH     GHV +  +L++HG  V++      G  PL
Sbjct: 655 LSKQANGNLGNK-SGLTPLHLVAQEGHVPVADVLIKHG--VMVDATTRMGYTPL 705



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 56/222 (25%), Positives = 94/222 (42%), Gaps = 25/222 (11%)

Query: 796  KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
            K++    T  KG TALH A +  Q E +  L++  G ++N +   G+TPL+ A    +  
Sbjct: 67   KEIILETTTKKGNTALHIAALAGQDEVVRELVNY-GANVNAQSQKGFTPLYMAAQENHLE 125

Query: 856  CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLD 915
             V+ +L+     ++ T+ DG TPL  AL  GH  +   L+ +G          K  LP  
Sbjct: 126  VVKFLLENGANQNVATE-DGFTPLAVALQQGHENVVAHLINYG-------TKGKVRLPAL 177

Query: 916  YVVSPQIKEELFAITKIEDTVENFHAQAEKHF-------HYQQLEFGSFLLSR-MLLNFC 967
            ++ +        A+    D   N    ++  F       HY+ L     LL+R   +NF 
Sbjct: 178  HIAARNDDTRTAAVLLQND--PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 968  SIFDLSSEFILASKGLTHLNELLM------ACKSHKETTSVH 1003
                ++   I + +G   +  LL+        K+  E T +H
Sbjct: 236  PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH 277



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 37/98 (37%), Positives = 50/98 (51%), Gaps = 3/98 (3%)

Query: 802 KTNLKGE-TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEI 860
           +T  K E T LH A  N  V    +LL   G  I  K   G +P+H A    +  CV+ +
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLD-HGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324

Query: 861 LQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           LQ   E+D +T +D +TPLH A   GH  + K+LL  G
Sbjct: 325 LQYDAEIDDIT-LDHLTPLHVAAHCGHHRVAKVLLDKG 361



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 37/109 (33%), Positives = 56/109 (51%), Gaps = 7/109 (6%)

Query: 804 NLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQR 863
           +++G T LH A      E + LLLS    + N+ + +G TPLH     G+      +++ 
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQA-NGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690

Query: 864 CPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGEL 912
              VD  T++ G TPLH A   G++++ K LLQH   V     NAK +L
Sbjct: 691 GVMVDATTRM-GYTPLHVASHYGNIKLVKFLLQHQADV-----NAKTKL 733



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 39/108 (36%), Positives = 57/108 (52%), Gaps = 8/108 (7%)

Query: 809 TALHRA--CINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           T LH A  C +++V K++L     G   N +   G+TPLH AC   +   ++ +L+    
Sbjct: 340 TPLHVAAHCGHHRVAKVLLD---KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           +D +T+  G+TPLH A   GH+ I K LLQ G    +   N K E PL
Sbjct: 397 IDAVTE-SGLTPLHVASFMGHLPIVKNLLQRGASPNVS--NVKVETPL 441



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 35/94 (37%), Positives = 44/94 (46%), Gaps = 2/94 (2%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           +N+K ET LH A      E    LL      +N K     TPLH A   G+T  V+ +L+
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKA-KVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQ 896
                +L T   G TPLH A   GHVE    LL+
Sbjct: 492 NNANPNLATTA-GHTPLHIAAREGHVETVLALLE 524



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 37/109 (33%), Positives = 48/109 (44%), Gaps = 4/109 (3%)

Query: 806 KGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCP 865
           KG T LH A    +V    LLL       N     G TPLH A ++ N   V+ +L R  
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHP-NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593

Query: 866 EVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
                   +G TPLH A     VE+ + LLQ+GG       + +G  PL
Sbjct: 594 SPHSPAW-NGYTPLHIAAKQNQVEVARSLLQYGGSA--NAESVQGVTPL 639



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 33/89 (37%), Positives = 43/89 (48%), Gaps = 2/89 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH A  +N ++ + LLL   G   +   N G+TPLH A         + +LQ    
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN-GYTPLHIAAKQNQVEVARSLLQYGGS 627

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLL 895
            +    V GVTPLH A   GH E+  LLL
Sbjct: 628 ANA-ESVQGVTPLHLAAQEGHAEMVALLL 655



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 30/101 (29%), Positives = 47/101 (46%), Gaps = 2/101 (1%)

Query: 798 MNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCV 857
           ++ +  N  G   LH A     V+ ++ LL    I +      G T LH A   G    V
Sbjct: 36  VDINTCNQNGLNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVV 94

Query: 858 QEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHG 898
           +E++     V+  +Q  G TPL+ A    H+E+ K LL++G
Sbjct: 95  RELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENG 134



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 35/107 (32%), Positives = 51/107 (47%), Gaps = 6/107 (5%)

Query: 809 TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVD 868
           T+  RA  +  ++K +  L   G+DIN  +  G   LH A   G+   V E+L +  E+ 
Sbjct: 14  TSFLRAARSGNLDKALDHLR-NGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK--EII 70

Query: 869 L-LTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           L  T   G T LH A   G  E+ + L+ +G  V  Q +  KG  PL
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQ--KGFTPL 115


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 81/315 (25%), Positives = 140/315 (44%), Gaps = 33/315 (10%)

Query: 718  TGVLGSGKIQVSKKIGQRPCFDSQRTLLMLNGTKQKQVEGLPELLDLNLAKCSSSLKKLK 777
            T  LG+  +Q  K +      D+ + + +L           P+ +DL L   +S L    
Sbjct: 397  TSDLGTTDVQKKKLVDAIVSGDTSKLMKILQ----------PQDVDLALDSGASLLHLAV 446

Query: 778  KKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVK 837
            +  + E  C+K     ++   N + +N +G T LH A +  +V  ++ LL    I +N K
Sbjct: 447  EAGQEE--CAKW---LLLNNANPNLSNRRGSTPLHMA-VERRVRGVVELLLARKISVNAK 500

Query: 838  DNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQH 897
            D   WT LH A   G+    + +L++   V+ +   +G TP+H A  +G   I ++LL+ 
Sbjct: 501  DEDQWTALHFAAQNGDESSTRLLLEKNASVNEV-DFEGRTPMHVACQHGQENIVRILLRR 559

Query: 898  GGPVLLQQRNA---------KGELPLDYVVSPQIKEELFAITKIEDTVENFHAQAEKHFH 948
            G  V LQ ++A         +G LP+  +++ Q    + A T   D     H  A++  H
Sbjct: 560  GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTL--DGRTPLHLAAQRG-H 616

Query: 949  YQQLEFGSFLLSRMLLNFCSIFDLSSEFILASKGLTHLNELLMACKSHKE--TTSVHTDW 1006
            Y+       L S   +N CS+   +   + A  G T    LL+   + KE  T+  +T  
Sbjct: 617  YRVARILIDLCSD--VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTAL 674

Query: 1007 LLDLYAGNIKTLQKL 1021
             L    G++ T++ L
Sbjct: 675  HLAARNGHLATVKLL 689



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 35/98 (35%), Positives = 46/98 (46%), Gaps = 2/98 (2%)

Query: 805 LKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRC 864
           L G T LH A          +L+ L   D+NV      TPLH A   G+T   + +L R 
Sbjct: 602 LDGRTPLHLAAQRGHYRVARILIDLCS-DVNVCSLLAQTPLHVAAETGHTSTARLLLHRG 660

Query: 865 PEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVL 902
              + +T  DG T LH A  NGH+   KLL++    VL
Sbjct: 661 AGKEAMTS-DGYTALHLAARNGHLATVKLLVEEKADVL 697



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 31/104 (29%), Positives = 51/104 (49%), Gaps = 3/104 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G TALH A  N  +  + LL+     D+  +     T LH A  +G++  V+E++     
Sbjct: 670 GYTALHLAARNGHLATVKLLVEEKA-DVLARGPLNQTALHLAAAHGHSEVVEELVS-ADV 727

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKG 910
           +DL  +  G++ LH A    H +  + LL+HG  + LQ    +G
Sbjct: 728 IDLFDE-QGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQG 770


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 36/102 (35%), Positives = 56/102 (54%), Gaps = 2/102 (1%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           +  N + +N  G T LH A   ++V    +L++  G  ++ +   G+TPLH  C+YGN  
Sbjct: 686 RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN-QGAHVDAQTKMGYTPLHVGCHYGNIK 744

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQH 897
            V  +LQ   +V+  T+ +G TPLH A   GH  I  +LLQ+
Sbjct: 745 IVNFLLQHSAKVNAKTK-NGYTPLHQAAQQGHTHIINVLLQN 785



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 56/218 (25%), Positives = 102/218 (46%), Gaps = 24/218 (11%)

Query: 787 SKENCPSVVKKMNFHKTNL-----KGETALHRACINNQVEKLILLLSLPGIDINVKDNAG 841
           SKE    VV ++   + N+     KG TALH A +  Q E ++ +L   G ++N +   G
Sbjct: 82  SKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAE-VVKVLVTNGANVNAQSQNG 140

Query: 842 WTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPV 901
           +TPL+ A    +   V+ +L       L T+ DG TPL  AL  GH ++  LLL++    
Sbjct: 141 FTPLYMAAQENHLEVVKFLLDNGASQSLATE-DGFTPLAVALQQGHDQVVSLLLEN---- 195

Query: 902 LLQQRNAKGELPLDYVVSPQIKEELFAITKIEDTVENFHAQAEKHF-------HYQQLEF 954
                + KG++ L  +     K++  A   +     N   +++  F       HY  +  
Sbjct: 196 -----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINV 250

Query: 955 GSFLLSR-MLLNFCSIFDLSSEFILASKGLTHLNELLM 991
            + LL+R   ++F +  D++   + + +G  ++ +LL+
Sbjct: 251 ATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL 288



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 39/112 (34%), Positives = 56/112 (50%), Gaps = 4/112 (3%)

Query: 803 TNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQ 862
           TN++GETALH A  + Q E ++  L   G  +  K     TPLH +   G    VQ++LQ
Sbjct: 462 TNVRGETALHMAARSGQAE-VVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ 520

Query: 863 RCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           +    +  T   G TPLH +   GH ++   LL HG  + +  +  KG  PL
Sbjct: 521 QGASPNAAT-TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK--KGFTPL 569



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 35/107 (32%), Positives = 55/107 (51%), Gaps = 4/107 (3%)

Query: 807 GETALHRACINNQVEKLILLLS-LPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCP 865
           G T LH A     +    LLL+    +D   +++   TPLH A   GN   V+ +L R  
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDI--TPLHVASKRGNANMVKLLLDRGA 292

Query: 866 EVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGEL 912
           ++D  T+ DG+TPLH    +GH ++ ++LL    P+L + +N    L
Sbjct: 293 KIDAKTR-DGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPL 338



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 34/98 (34%), Positives = 50/98 (51%), Gaps = 2/98 (2%)

Query: 810 ALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDL 869
           ALH A   +  +   LLL     + +V+  +G+TPLH A +YGN      +L R   VD 
Sbjct: 205 ALHIAARKDDTKAAALLLQNDN-NADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDF 263

Query: 870 LTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRN 907
             + D +TPLH A   G+  + KLLL  G  +  + R+
Sbjct: 264 TARND-ITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 44/153 (28%), Positives = 72/153 (47%), Gaps = 14/153 (9%)

Query: 766 LAKCSSSLKKLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGE--TALHRA--CINNQVE 821
           L+K  + L  L   ++G+      NC  ++ + N    ++  +  TALH A  C + +V 
Sbjct: 328 LSKTKNGLSPLHMATQGD----HLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVA 383

Query: 822 KLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHD 881
           K++L       + N K   G+TPLH AC       ++ +L+    +  +T+  G+TP+H 
Sbjct: 384 KVLLDKKA---NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTE-SGLTPIHV 439

Query: 882 ALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           A   GHV I   L+ HG        N +GE  L
Sbjct: 440 AAFMGHVNIVSQLMHHGASP--NTTNVRGETAL 470



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 42/137 (30%), Positives = 66/137 (48%), Gaps = 8/137 (5%)

Query: 775 KLKKKSEGELSCSKENCPSVVKKMNFHKTNLKGETALH----RACINNQVEKLILLLSLP 830
           +LKK  + E++  +E  P   +K      + K ++  +    RA     +EK +  +   
Sbjct: 7   QLKKNRDLEINAEEE--PEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIK-N 63

Query: 831 GIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEI 890
           G+DIN+ +  G   LH A   G+   V E+LQR   VD  T+  G T LH A   G  E+
Sbjct: 64  GVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK-KGNTALHIASLAGQAEV 122

Query: 891 GKLLLQHGGPVLLQQRN 907
            K+L+ +G  V  Q +N
Sbjct: 123 VKVLVTNGANVNAQSQN 139



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 33/109 (30%), Positives = 54/109 (49%), Gaps = 4/109 (3%)

Query: 806 KGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCP 865
           +G  ++H A     V+ + LLL     ++N+ + +G TPLH A         + ++ +  
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGR-NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721

Query: 866 EVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
            VD  T++ G TPLH     G+++I   LLQH   V  + +N  G  PL
Sbjct: 722 HVDAQTKM-GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN--GYTPL 767



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 33/93 (35%), Positives = 45/93 (48%), Gaps = 2/93 (2%)

Query: 809 TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVD 868
           T LH A        + LLL   G  I+ K   G TPLH     G+   V+ +L R   + 
Sbjct: 270 TPLHVASKRGNANMVKLLLDR-GAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328

Query: 869 LLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPV 901
             T+ +G++PLH A    H+   +LLLQH  PV
Sbjct: 329 SKTK-NGLSPLHMATQGDHLNCVQLLLQHNVPV 360



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 55/225 (24%), Positives = 93/225 (41%), Gaps = 17/225 (7%)

Query: 807  GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
            G T LH +      +    LL   G  +++    G+TPLH A  YG       +LQ+   
Sbjct: 532  GYTPLHLSAREGHEDVAAFLLD-HGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 590

Query: 867  VDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPLDYVVSPQIKEEL 926
             D   +  G+TPLH A    + ++  LLL  G       +N  G  PL        K ++
Sbjct: 591  PDAAGK-SGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN--GYTPLHIAAK---KNQM 644

Query: 927  FAITKIEDTVENFHAQ-----AEKHFHYQQ--LEFGSFLLSRML-LNFCSIFDLSSEFIL 978
               T + +   + +A      A  H   Q+  ++  S LL R   +N  +   L+   + 
Sbjct: 645  DIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLA 704

Query: 979  ASKGLTHLNELLMACKSH--KETTSVHTDWLLDLYAGNIKTLQKL 1021
            A +   ++ E+L+   +H   +T   +T   +  + GNIK +  L
Sbjct: 705  AQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 27/84 (32%), Positives = 41/84 (48%), Gaps = 2/84 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH  C    + K++  L      +N K   G+TPLH+A   G+T  +  +LQ    
Sbjct: 730 GYTPLHVGCHYGNI-KIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788

Query: 867 VDLLTQVDGVTPLHDALSNGHVEI 890
            + LT V+G T L  A   G++ +
Sbjct: 789 PNELT-VNGNTALGIARRLGYISV 811



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 31/89 (34%), Positives = 44/89 (49%), Gaps = 2/89 (2%)

Query: 807 GETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPE 866
           G T LH    +   E+++ +L      I  K   G +PLH A    +  CVQ +LQ    
Sbjct: 301 GLTPLHCGARSGH-EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVP 359

Query: 867 VDLLTQVDGVTPLHDALSNGHVEIGKLLL 895
           VD +T  D +T LH A   GH ++ K+LL
Sbjct: 360 VDDVTN-DYLTALHVAAHCGHYKVAKVLL 387


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 43/139 (30%), Positives = 70/139 (50%), Gaps = 6/139 (4%)

Query: 778 KKSEGELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVK 837
           +K   ++  +K       K++N +  +  G +ALH A +   +E + LLL      +++K
Sbjct: 20  QKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQAT-VDIK 78

Query: 838 DNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQH 897
           D+ G  PLH A   G    V+ +L+    V+  + +DG  PLH A   GH E+ ++LLQH
Sbjct: 79  DSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAAS-LDGQIPLHLAAQYGHYEVSEMLLQH 137

Query: 898 -GGPVLLQQRNAKGELPLD 915
              P L+   N   + PLD
Sbjct: 138 QSNPCLV---NKAKKTPLD 153



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 29/106 (27%), Positives = 51/106 (48%), Gaps = 3/106 (2%)

Query: 809 TALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVD 868
           T + +     +  K  LL S   +++N +D  G++ LH A   G+   +  +L+    VD
Sbjct: 17  TGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVD 76

Query: 869 LLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
            +   +G+ PLH A   G +E  +LLL+    V     +  G++PL
Sbjct: 77  -IKDSNGMRPLHYAAWQGRLEPVRLLLRASAAV--NAASLDGQIPL 119



 Score = 37.0 bits (84), Expect = 0.098
 Identities = 25/75 (33%), Positives = 40/75 (53%), Gaps = 4/75 (5%)

Query: 843 TPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQHGGPVL 902
           TPLH A   G+   ++++L+   E++  T+    T LH+A   G  E+ +LLL+ G  V 
Sbjct: 191 TPLHLAAKNGHREVIRQLLRAGIEINRQTKTG--TALHEAALYGKTEVVRLLLEGGVDVN 248

Query: 903 LQQRNAKGELPLDYV 917
           +  RN   +  LD V
Sbjct: 249 I--RNTYNQTALDIV 261



 Score = 34.3 bits (77), Expect = 0.64
 Identities = 33/102 (32%), Positives = 43/102 (42%), Gaps = 8/102 (7%)

Query: 804 NLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQR 863
           +L G+  LH A      E   +LL        V + A  TPL  AC +G     Q +L  
Sbjct: 112 SLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLV-NKAKKTPLDLACEFGRLKVAQLLLNS 170

Query: 864 CPEVDLLT-------QVDGVTPLHDALSNGHVEIGKLLLQHG 898
              V LL          +  TPLH A  NGH E+ + LL+ G
Sbjct: 171 HLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAG 212



 Score = 30.8 bits (68), Expect = 7.1
 Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 6/97 (6%)

Query: 806 KGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCP 865
           K  TALH A +  + E + LLL   G+D+N+++    T L     +  +   +EI Q   
Sbjct: 220 KTGTALHEAALYGKTEVVRLLLE-GGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLR 278

Query: 866 EVDLLTQVDGVTP---LHD--ALSNGHVEIGKLLLQH 897
           E   + +V  +     LHD  AL+    ++  +L QH
Sbjct: 279 EASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQH 315


>gi|18079216 CASK interacting protein 1 [Homo sapiens]
          Length = 1431

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 40/121 (33%), Positives = 65/121 (53%), Gaps = 6/121 (4%)

Query: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
           KK+N +  +  G +ALH A +N   E + LLL      +++KDN G  PLH A   G   
Sbjct: 38  KKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAA-VDIKDNKGMRPLHYAAWQGRKE 96

Query: 856 CVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQH-GGPVLLQQRNAKGELPL 914
            ++ +L+    V++ +  +G  PLH A  +GH ++ ++LLQH   P ++      G+ PL
Sbjct: 97  PMKLVLKAGSAVNIPSD-EGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDN---SGKTPL 152

Query: 915 D 915
           D
Sbjct: 153 D 153



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 53/203 (26%), Positives = 88/203 (43%), Gaps = 22/203 (10%)

Query: 806 KGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCP 865
           +G   LH A  +   +   +LL        V DN+G TPL  AC +G    VQ +L    
Sbjct: 114 EGHIPLHLAAQHGHYDVSEMLLQHQSNPCMV-DNSGKTPLDLACEFGRVGVVQLLLSSNM 172

Query: 866 EVDLL-------TQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKG-------- 910
              LL       T  +G +PLH A  NGH++I +LLLQ G  +  Q ++           
Sbjct: 173 CAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCG 232

Query: 911 -----ELPLDYVVSPQIKEELFAITKIEDTVENFHAQAEKHFHYQQLEFGSFLLSRMLLN 965
                 L LD  ++  ++   ++ T ++   +   +QA +       E  + L  R   +
Sbjct: 233 KTEVVRLLLDSGINAHVR-NTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKD 291

Query: 966 FCSIFDLSSEFILASKGLTHLNE 988
           +C+ +DL+S  + A   +T L +
Sbjct: 292 YCNNYDLTSLNVKAGDIITVLEQ 314



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 32/93 (34%), Positives = 48/93 (51%), Gaps = 3/93 (3%)

Query: 822 KLILLLSLPGIDINVKDNAGWTPLHEACNYGNTVCVQEILQRCPEVDLLTQVDGVTPLHD 881
           K  LL S   I++N +D  G++ LH A   GNT  +  +L+    VD+     G+ PLH 
Sbjct: 30  KAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDN-KGMRPLHY 88

Query: 882 ALSNGHVEIGKLLLQHGGPVLLQQRNAKGELPL 914
           A   G  E  KL+L+ G  V +   + +G +PL
Sbjct: 89  AAWQGRKEPMKLVLKAGSAVNIP--SDEGHIPL 119



 Score = 38.1 bits (87), Expect = 0.044
 Identities = 27/79 (34%), Positives = 41/79 (51%), Gaps = 2/79 (2%)

Query: 783 ELSCSKENCPSVVKKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGW 842
           +L  S   C ++++      T+  G + LH A  N  ++ +I LL   GIDIN +  +G 
Sbjct: 165 QLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHID-IIRLLLQAGIDINRQTKSG- 222

Query: 843 TPLHEACNYGNTVCVQEIL 861
           T LHEA   G T  V+ +L
Sbjct: 223 TALHEAALCGKTEVVRLLL 241


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,338,190
Number of Sequences: 37866
Number of extensions: 1769939
Number of successful extensions: 7935
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 233
Number of HSP's that attempted gapping in prelim test: 5665
Number of HSP's gapped (non-prelim): 1515
length of query: 1058
length of database: 18,247,518
effective HSP length: 113
effective length of query: 945
effective length of database: 13,968,660
effective search space: 13200383700
effective search space used: 13200383700
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.