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Search of human proteins with 187937176
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
(1037 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 2110 0.0
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 2033 0.0
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 1905 0.0
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 1219 0.0
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 577 e-164
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 474 e-133
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 468 e-131
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 460 e-129
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 452 e-126
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 444 e-124
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 433 e-121
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 433 e-121
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 421 e-117
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 394 e-109
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 392 e-109
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 360 3e-99
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 359 7e-99
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 316 8e-86
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 316 8e-86
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 316 8e-86
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 312 9e-85
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 312 9e-85
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 244 3e-64
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 219 1e-56
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 145 2e-34
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 145 2e-34
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 145 2e-34
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 145 2e-34
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 145 2e-34
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 145 2e-34
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 2110 bits (5466), Expect = 0.0
Identities = 1037/1037 (100%), Positives = 1037/1037 (100%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
Query: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA
Sbjct: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
Query: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS
Sbjct: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
Query: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT
Sbjct: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
Query: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG
Sbjct: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
Query: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA
Sbjct: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
Query: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY
Sbjct: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
Query: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE
Sbjct: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
Query: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA
Sbjct: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
Query: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ
Sbjct: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
Query: 901 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 960
EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK
Sbjct: 901 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 960
Query: 961 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI
Sbjct: 961 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
Query: 1021 DCNASGATAPPCCDFFC 1037
DCNASGATAPPCCDFFC
Sbjct: 1021 DCNASGATAPPCCDFFC 1037
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform 1
[Homo sapiens]
Length = 1009
Score = 2033 bits (5267), Expect = 0.0
Identities = 1009/1037 (97%), Positives = 1009/1037 (97%), Gaps = 28/1037 (2%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
Query: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA
Sbjct: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
Query: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS
Sbjct: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
Query: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT
Sbjct: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
Query: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG
Sbjct: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
Query: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA
Sbjct: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE----------------- 643
Query: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY
Sbjct: 644 -----------SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 692
Query: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE
Sbjct: 693 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 752
Query: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA
Sbjct: 753 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 812
Query: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ
Sbjct: 813 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 872
Query: 901 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 960
EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK
Sbjct: 873 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 932
Query: 961 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI
Sbjct: 933 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
Query: 1021 DCNASGATAPPCCDFFC 1037
DCNASGATAPPCCDFFC
Sbjct: 993 DCNASGATAPPCCDFFC 1009
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 1905 bits (4934), Expect = 0.0
Identities = 938/938 (100%), Positives = 938/938 (100%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
Query: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA
Sbjct: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
Query: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS
Sbjct: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
Query: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT
Sbjct: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
Query: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG
Sbjct: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
Query: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA
Sbjct: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
Query: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY
Sbjct: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
Query: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE
Sbjct: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
Query: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA
Sbjct: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
Query: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ
Sbjct: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
Query: 901 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRL 938
EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRL
Sbjct: 901 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRL 938
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 1219 bits (3153), Expect = 0.0
Identities = 656/1060 (61%), Positives = 767/1060 (72%), Gaps = 56/1060 (5%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
++S Q+ + LQ LLEQL++DEL FK L+ F L LQK P EV++ADGK+L EIL
Sbjct: 2 VSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTT 61
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQ------------VQEIDNPELGDA 108
W+ A++ + E+M+ +L + AK E+ E + + P L D
Sbjct: 62 HCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPL-DV 120
Query: 109 EEDSELAKP---------------------GEKEGWRNSME-----KQSLVWKNTFWQGD 142
+E E K G+K N K +WK+ W GD
Sbjct: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKS--WPGD 178
Query: 143 IDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSP 202
+ R + IPF NPR YTVVL+GPAG+GKTTLA+K MLDW + NL
Sbjct: 179 SKEVQV-MAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH 237
Query: 203 TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPP 262
+YAFYLSC+ELSR+GPCSFAEL+ +DWPELQDDIP ILAQA++ILFV+DG DEL P
Sbjct: 238 KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAP 297
Query: 263 GALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVE 322
GALI+DICGDWEKKKPVPVLLGSLL R MLP+AALLVTTRPRALRDL++LA++PIY+RVE
Sbjct: 298 GALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVE 357
Query: 323 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 382
GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED
Sbjct: 358 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 417
Query: 383 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE 442
PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQ SV HREDLERLGVQE
Sbjct: 418 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQE 477
Query: 443 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQK 502
SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY LEKEE EDRDGH WDIGDVQK
Sbjct: 478 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQK 537
Query: 503 LLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKP 562
LLSG ERL+NPDLIQ G++ FGLANEKRAKELEATFGCRMSPDIKQELL+C
Sbjct: 538 LLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHS 597
Query: 563 LSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSL 622
+VTDL+E+LGCLYESQEEEL K V+A FKEIS+HL N +V+ SF +KHC++LQK+SL
Sbjct: 598 -TVTDLQELLGCLYESQEEELVKEVMAQFKEISLHL-NAVDVVPSSFCVKHCRNLQKMSL 655
Query: 623 QVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEV 682
QV K EN E D E ER ++ D L WTD CS+F SN +L L +
Sbjct: 656 QVIKENLPENVTASESDAEVER---------SQDDQHMLPFWTDLCSIFGSNKDLMGLAI 706
Query: 683 KQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHI 742
SFLS S VRILC+ + TCHLQ+V KN++P A+R+ CLA G KT+T+LTL G+
Sbjct: 707 NDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGND 766
Query: 743 EWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLL 802
+ + M LC++LR+ +CNL+YL L AT +QWA+ L+ NQSL + LS N LL
Sbjct: 767 QDD--MFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELL 824
Query: 803 DEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTG 862
DEGA LLY T+ PK FLQ LSLENC LTEA+CKDLAAVLVVS++LTHLCLAKNPIG+TG
Sbjct: 825 DEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTG 884
Query: 863 VKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWI 921
VKFLCEGL YP+CKLQTLVL C IT GC L++ LQE SL LDL +N I +G+
Sbjct: 885 VKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKF 944
Query: 922 LCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFG 981
LC+AL P CNL+ L LW CS+ PF C+ L SAL NQ L TLDLGQN L SG+ LF
Sbjct: 945 LCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFE 1004
Query: 982 VLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTID 1021
L +G+L+ LRLK + N E+ KLLEE++EKNP+L ID
Sbjct: 1005 TLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLIID 1044
Score = 63.9 bits (154), Expect = 7e-10
Identities = 59/201 (29%), Positives = 85/201 (42%), Gaps = 1/201 (0%)
Query: 837 DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 896
DL ++ +K L L + + + + V+ LCE ++ C LQ +V + S R L
Sbjct: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLC 748
Query: 897 EALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALL 956
AL+ ++T L L N LC+ L +P CNL++L L SCS L AL
Sbjct: 749 LALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
Query: 957 SNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNP 1016
NQ L ++L N L G L+ LR L+ L L+ K L V +
Sbjct: 809 VNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSR 868
Query: 1017 KLTIDCNASGATAPPCCDFFC 1037
+LT C A F C
Sbjct: 869 ELTHLCLAKNPIGNTGVKFLC 889
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 577 bits (1487), Expect = e-164
Identities = 386/1093 (35%), Positives = 559/1093 (51%), Gaps = 100/1093 (9%)
Query: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
++ L LE+LN++EL +FK L +E TPW+EV++A + LA ++
Sbjct: 12 DFGLLLYLEELNKEELNTFKLFLKE-TMEPEHGLTPWNEVKKARREDLANLMKKYYPGEK 70
Query: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNS 126
+ ++ I +MNL +LC+ AK E+ Q D+ + G+ +ED E A G+ +RN
Sbjct: 71 AWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQE-AVLGDGTEYRNR 129
Query: 127 M-EKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFL-NPRTPRKLTPYTVVLHGPAGVGK 184
+ EK + W G ++FH + ++++ + L + P VVL G AGVGK
Sbjct: 130 IKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGK 189
Query: 185 TTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILA 243
TTL +K MLDW + +L +Y FYL+ +E++++ SFA+LISKDWP + I I+
Sbjct: 190 TTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMY 249
Query: 244 QAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRP 303
Q +LF++D DEL +C DW ++ PV L+ SLL++ MLP A+LLVTTR
Sbjct: 250 QPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRL 309
Query: 304 RALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAP 363
+ L+ L + YV + G E+ R Y + F D+ AM+ F ++SN LF + P
Sbjct: 310 TTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVP 369
Query: 364 AVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF----------PQGAQLRGALR 413
VCW CT LK QMEKG D TC T T LF ++ S F P AQLR
Sbjct: 370 LVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLR---- 425
Query: 414 TLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQ 473
L +AA+G+W VF+RE+L RLG+ +SD+ F+D +I+++D + CY F HL Q+
Sbjct: 426 RLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQE 485
Query: 474 FLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKE 533
F A+FY L K E + D++ LL K+P L Q+ FLFGL NE R K+
Sbjct: 486 FFAAMFYML-KGSWEAGNPSCQPFEDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQ 543
Query: 534 LEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK--EVLGCLYESQEEELAKVVVAPF 591
LE TF C+MS IK +LLQC L N S + L E+ CLYE+Q++ + F
Sbjct: 544 LERTFNCKMSLKIKSKLLQCMEVL-GNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCF 602
Query: 592 KEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLT-I 650
+++I++ ++ SF LKHC+ L+ + L V + FE+ T +
Sbjct: 603 PKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVT--------------VVFEKKILKTSL 648
Query: 651 PNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVE 710
P R W D CS+ +N +L+ L++ S L S++ IL + C LQK+
Sbjct: 649 PTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLL 708
Query: 711 IKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGG 770
+K +T +D + I K L HL L G + + LC+ L++ +C LQ LRL
Sbjct: 709 LKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVK-SLCEALKHPECKLQTLRLES 767
Query: 771 HCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRL 830
T L +QSL L LS N LLD+G LL + + PK +L+ LSLE+C L
Sbjct: 768 CNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGL 827
Query: 831 TEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKL 890
TEA C+ L+ L+ +K+LTHLCLA N +GD GVK + + L + C L++LVL++C T L
Sbjct: 828 TEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSL 887
Query: 891 GCRYLSEALQE---------------------------------------ACSLTN---- 907
YLS +L C LTN
Sbjct: 888 SSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCL 947
Query: 908 --------------LDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLG 952
LDL N + G+ ILC AL PNCN++ L L C L CQ L
Sbjct: 948 DLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLS 1007
Query: 953 SALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVK 1012
SAL+ N++L ++L QN L GI+KL+ VL+ L++L L + E +KLLE V
Sbjct: 1008 SALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVG 1067
Query: 1013 EKNPKLTI--DCN 1023
NP L I DCN
Sbjct: 1068 VSNPHLIIKPDCN 1080
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 474 bits (1220), Expect = e-133
Identities = 336/1048 (32%), Positives = 530/1048 (50%), Gaps = 99/1048 (9%)
Query: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
++ L LE+L ++E + FK L L+ L++ PW+EV++A ++LA +L+ E
Sbjct: 8 DFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQ 67
Query: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRN- 125
N T+ I ++M+ +LC E G + AK W +
Sbjct: 68 AWNITLRIFQKMDRKDLCMKVMRE-------------RTGYTKTYQAHAKQKFSRLWSSK 114
Query: 126 SMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKT 185
S+ + L ++ Q + D+ ++ F P + PR TV++ GP G+GKT
Sbjct: 115 SVTEIHLYFEEEVKQEECDHL-------DRLFAPKEAGKQPR-----TVIIQGPQGIGKT 162
Query: 186 TLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQ 244
TL K M+ W+D + Y FY C+EL + P S A+LIS++WP+ I I++Q
Sbjct: 163 TLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQ 222
Query: 245 AQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTR-- 302
+R+LFV+D +EL+ D+CGD +K+PV VLL SLL++KMLP A+LL+ +
Sbjct: 223 PERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPV 282
Query: 303 -PRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGS 361
P+ LRD +++ IY + GF E DR YF F D +AM AF L+R + LF +
Sbjct: 283 CPKELRDQVTISE--IY-QPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQ 339
Query: 362 APAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-----QLRGALRTL 415
P +CWI+CT+LK +M+KG+D TC + T ++ F+ + F P+GA Q + L+ L
Sbjct: 340 IPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKAL 399
Query: 416 SLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFL 475
LAA+G+W F +DL R GV ++D+ L IL + + Y F+H+ Q+F
Sbjct: 400 CSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFC 459
Query: 476 TALFYALEKEEGEDRDGHAWDIGDVQKLL-SGEERLKNPDLIQVGHFLFGLANEKRAKEL 534
ALFY L+ + VQ+LL + E+ + I +G FL GL N+K ++L
Sbjct: 460 AALFYLLKSHLDHPHPA----VRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKL 515
Query: 535 EATFGCRMSPDIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKE 593
+A FG ++S +IKQ++ QC L P D + CL+E Q+ K V +E
Sbjct: 516 DAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQE 575
Query: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNW 653
+ H+ + +++ ++ LK+C L+KL V + VF + D Y
Sbjct: 576 ANFHIIDNVDLVVSAYCLKYCSSLRKLCFSV-QNVFKKE------DEHSSTSDY------ 622
Query: 654 ARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKN 713
SL W CS+ +++ +L+ L+V+ S LS+S+ C+ + +C LQK+ I N
Sbjct: 623 ------SLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINN 676
Query: 714 VT---------------PDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRN 758
V+ PD Y F TLT L+ R + LCD L
Sbjct: 677 VSFSGQSVLLFEVLFYQPDLKYLSF--------TLTKLS--------RDDIRSLCDALNY 720
Query: 759 HKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKH 818
N++ L L +P +L N+ L +L +S N LD G LL + + P
Sbjct: 721 PAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCN-QLDTGVPLLCEALCSPDT 779
Query: 819 FLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ 878
L L L C L+E C+ ++ +L+ +K + +L L+ N + D G+K LCE L +PDC L
Sbjct: 780 VLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLD 839
Query: 879 TLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLR 937
+L L +C IT GC L+ AL +L L + N+I G+ +LC+AL + +C L+ L
Sbjct: 840 SLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILG 899
Query: 938 LWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKT 997
L C L C+ L S L ++ L+ L+L N L +G++ L LR +L++L L+
Sbjct: 900 LEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRK 959
Query: 998 YETNLEIKKLLEEVKEKNPKLTI--DCN 1023
+ + E + LL +E+NP LTI DC+
Sbjct: 960 TDFDEETQALLTAEEERNPNLTITDDCD 987
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 468 bits (1205), Expect = e-131
Identities = 336/1045 (32%), Positives = 508/1045 (48%), Gaps = 88/1045 (8%)
Query: 14 LEQLNEDELKSFKSLL--------WAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSEN 65
L L++ +L+ FK L W+ P + + PW+ + AD L+ +L +
Sbjct: 21 LMALDQYQLEEFKLCLEPQQLMDFWSAP-QGHFPRIPWANLRAADPLNLSFLLDEHFPKG 79
Query: 66 WIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNP---------------------- 103
+ I + MNLT LC+ +AEM E+ Q QE+ +P
Sbjct: 80 QAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQD 139
Query: 104 ----ELGDAEEDSE-----------------LAKPGEKEGWRNSMEKQSL-VWKNTFWQG 141
EL + EE++ L + + +R +M+ + L W N W
Sbjct: 140 PNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPK 199
Query: 142 DIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
D + ++ L+P R T+VL G AGVGKTTLA + ML W + L
Sbjct: 200 DHVYIRNTSKDEHEELQRLLDPNRTRAQAQ-TIVLVGRAGVGKTTLAMQAMLHWANGVLF 258
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FYLSC ++ M +FAELIS DWP+ I ++Q +++LF++DG +E+ +
Sbjct: 259 QQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIII 318
Query: 261 PPGALIQ----DICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQP 316
C DW ++ PV +L SLLK++++P A LL+T + +RDL+ P
Sbjct: 319 SESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNP 378
Query: 317 IYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQ 376
+V++ GF +D R YF+RHF D + + + +R N LF SAP VCW VC+ LK
Sbjct: 379 CFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQP 438
Query: 377 MEKGEDPVPTCLTRTGLFLRFLCSRFPQGA------QLRGALRTLSLLAAQGLWAQMSVF 430
+ D T T L+ F + F G R L LA +GLW+ F
Sbjct: 439 KVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTF 498
Query: 431 HREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDR 490
++ED E G++ + + +IL++ GC +F HLSFQ+F A+ + L EE +
Sbjct: 499 NKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVL--EEPREF 556
Query: 491 DGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQEL 550
H+ +++ LL K V F FGL N+ A+ELE T C++SP + +EL
Sbjct: 557 PPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEEL 616
Query: 551 LQCKAHLHANKPLSVT-DLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSF 609
L+ L + S+ + + CL+ESQEE+ K ++ E+ +++ E+ SF
Sbjct: 617 LKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSF 676
Query: 610 SLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCS 669
LKHC+ L KL L V+ + E D+E I ++ D R + W CS
Sbjct: 677 CLKHCKRLNKLRLSVSSHI-------LERDLE--------ILETSKFDSR-MHAWNSICS 720
Query: 670 LFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIG 729
+N NL L++ S L SSV+ LC + C +QK+ K+VTP+ +D +A G
Sbjct: 721 TLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQG 780
Query: 730 KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQ 789
LTHL + + + T+ L+L LR+ CNL+YL L + + L + Q
Sbjct: 781 NSKLTHLNFSSN-KLGMTVPLIL-KALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQ 838
Query: 790 SLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLT 849
+ L L N L D+G LL +T PK L+ L L C+L +CK L+ L+ ++ LT
Sbjct: 839 HVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLT 898
Query: 850 HLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLD 909
HL L+KN + D GVKFLCE L PD LQ+L L CS T+ GC L+ AL ++ LD
Sbjct: 899 HLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILD 958
Query: 910 LSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQ 968
L N + G+ +LC+AL+ P+ L L L C+L CQHL S L S++ L L+L
Sbjct: 959 LGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLG 1017
Query: 969 NHLWKSGIIKLFGVLRQRTGSLKIL 993
N L G+ L L++ T L+ L
Sbjct: 1018 NELDTDGVKMLCKALKKSTCRLQKL 1042
Score = 101 bits (251), Expect = 4e-21
Identities = 70/219 (31%), Positives = 109/219 (49%), Gaps = 3/219 (1%)
Query: 778 WAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 837
W L N++L L LS + L L + P+ +Q L+ ++ E +D
Sbjct: 715 WNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQD 773
Query: 838 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 897
L L + KLTHL + N +G T V + + L + C L+ L L++C+++ C+ L+
Sbjct: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
Query: 898 ALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALL 956
L +T L L N++ G+ +LC AL +P C L+ L LW C L C+HL ALL
Sbjct: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
Query: 957 SNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 995
N+ L L+L +N L G+ L L + G+L+ L L
Sbjct: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNL 931
Score = 70.9 bits (172), Expect = 6e-12
Identities = 57/182 (31%), Positives = 87/182 (47%), Gaps = 1/182 (0%)
Query: 838 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 897
+ + LV ++ L L L+ + + + VK LC L P CK+Q L + + + + L
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQDLII 776
Query: 898 ALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLS 957
ALQ LT+L+ S N++ + ++ +AL + CNLK+L L C+L CQ L L S
Sbjct: 777 ALQGNSKLTHLNFSSNKLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTS 836
Query: 958 NQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPK 1017
Q + L LG N L GI L L +L+ L L + K L + +N
Sbjct: 837 IQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRS 896
Query: 1018 LT 1019
LT
Sbjct: 897 LT 898
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 460 bits (1183), Expect = e-129
Identities = 308/978 (31%), Positives = 496/978 (50%), Gaps = 33/978 (3%)
Query: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
+ ++ +EL+ FK LL L W +VE A ++ +L+ + T N
Sbjct: 45 MRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSN 103
Query: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWR-NSMEKQSL 132
I MN ++C + + E+ E ++ +G+ + + E + G+ ++ N MEK
Sbjct: 104 IFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFP 163
Query: 133 VWKNTFWQGDIDNFHDDVTLRNQRFIP-FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
+W T W G+ +F R++ ++P L P+ P+ P TV + G G+GKT LAKK
Sbjct: 164 IWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKV 223
Query: 192 MLDWTDCNLSPTLRY-AFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
M +W R+ AFY C+E+++ SF+ELI + WP QD + I+++ ++L
Sbjct: 224 MFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLL 283
Query: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
++DG +EL ++D+ DW +K P VLL SLL + MLP A LL+ R + + +
Sbjct: 284 LLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCK 343
Query: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
L + P V + GF ++ YF +FG ++ + N LF + P VCW+VC
Sbjct: 344 PLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVC 403
Query: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ------LRGALRTLSLLAAQGLW 424
+ LK QME+G + +C T +F+R++ S FP A+ + L L LAA +W
Sbjct: 404 SGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMW 463
Query: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
+ V +EDLE + ++ + FL ILR+ + Y F ++FQ+F ALFY L
Sbjct: 464 HRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCF 523
Query: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
+ ++ H ++Q+L++ K+ L +G FLFG NE A +E +F C++S
Sbjct: 524 PQ-RLKNFHVLSHVNIQRLIASPRGSKS-YLSHMGLFLFGFLNEACASAVEQSFQCKVSF 581
Query: 545 DIKQELLQCKAHLH-ANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
K++LL+ LH + P + + ++ CL+E +EE + + ++ + + N E
Sbjct: 582 GNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKE 641
Query: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSL-R 662
V +F LK CQ L ++ L V N+M+ + + + P + L R
Sbjct: 642 VQVSAFCLKRCQYLHEVELTVTL-----NFMN------VWKLSSSSHPGSEAPESNGLHR 690
Query: 663 LWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRD 722
W D CS+F++N L+ L + S L ++ L + C LQK+ ++ V +D
Sbjct: 691 WWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQD 750
Query: 723 FCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
G + L +L + H+E E + +LC +LR+ +C LQ LRL ATP W +
Sbjct: 751 LIGVLTGNQHLRYLEIQ-HVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLG 809
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
L+ N LK L L N L + GA L L+ LS+ENC LT+ +C+ LA+ L
Sbjct: 810 NNLQGNGHLKTLILRKNSLENCGAYYLSVAQ------LERLSIENCNLTQLTCESLASCL 863
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
SK LTHL LA+N + D G K + L + C LQ LVL++C +T C+ + AL +
Sbjct: 864 RQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKN 923
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKL 961
+L +LDLS N + G+ +LC+AL+NP+C L+ L L +C CQ + S L NQ L
Sbjct: 924 KTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHL 983
Query: 962 ETLDLGQNHLWKSGIIKL 979
LDL +N + GI+ L
Sbjct: 984 RHLDLSKNAIGVYGILTL 1001
Score = 100 bits (248), Expect = 9e-21
Identities = 84/281 (29%), Positives = 133/281 (47%), Gaps = 15/281 (5%)
Query: 720 YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWA 779
++D C F L LT+ + + L LR+ +C LQ L L +T
Sbjct: 692 WQDLCSVFATNDKLEVLTMTNSVLGP-PFLKALAAALRHPQCKLQKLLLRRVNSTMLN-Q 749
Query: 780 EFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLA 839
+ VL NQ L++L + + + LL + + P+ LQ L LE+C T DL
Sbjct: 750 DLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLG 809
Query: 840 AVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEAL 899
L + L L L KN + + G +L +L+ L ++ C++T+L C L+ L
Sbjct: 810 NNLQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCL 863
Query: 900 QEACSLTNLDLSINQI----ARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSAL 955
+++ LT+L L+ N + A+ +W AL + C L+ L L C L CQ + SAL
Sbjct: 864 RQSKMLTHLSLAENALKDEGAKHIW---NALPHLRCPLQRLVLRKCDLTFNCCQDMISAL 920
Query: 956 LSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLK 996
N+ L++LDL N L G+I L L+ +L+IL L+
Sbjct: 921 CKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELE 961
Score = 87.8 bits (216), Expect = 5e-17
Identities = 72/234 (30%), Positives = 108/234 (46%), Gaps = 14/234 (5%)
Query: 645 CTYLTIPNWARQDLR------SLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDH 698
C L P Q LR + R+WTD + N +LK L ++++ L + C
Sbjct: 780 CRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLEN------CGA 833
Query: 699 VTRSTCHLQKVEIKNVT-PDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLR 757
S L+++ I+N K LTHL+LA + + + + L
Sbjct: 834 YYLSVAQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAK-HIWNALP 892
Query: 758 NHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPK 817
+ +C LQ L L T + L N++LK L LS N L D+G +LL + + P
Sbjct: 893 HLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPD 952
Query: 818 HFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLS 871
LQ+L LENC T C+ +A++L ++ L HL L+KN IG G+ LCE S
Sbjct: 953 CTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFS 1006
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 452 bits (1162), Expect = e-126
Identities = 315/1021 (30%), Positives = 518/1021 (50%), Gaps = 75/1021 (7%)
Query: 14 LEQLNEDELKSFKSLLWAFPLEDV-LQKTPWSEVEEADGKKLAEILVNTSSENWIRNATV 72
L++L ++E FK LL PLE L+ PW+E+++A + +A++L T+
Sbjct: 15 LKELRKEEFWKFKELLKQ-PLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
Query: 73 NILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQ-S 131
N+ ++N +L A+ EM NP +R M++
Sbjct: 74 NLFLQINRKDLWTKAQEEMRNKL------NP-------------------YRKHMKETFQ 108
Query: 132 LVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
L+W+ ++F+ + T++N+ LN +TVVL GP G+GKTTL +K
Sbjct: 109 LIWEKETCLHVPEHFYKE-TMKNE--YKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKV 165
Query: 192 MLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
MLDW + NL + F+L+ E++ + S EL+S+DWPE + I I +Q +RILF
Sbjct: 166 MLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILF 225
Query: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
++DG ++LK L D+ DW +++P+P++L SLL++KMLP ++LL+ A++
Sbjct: 226 IMDGFEQLKFNL-QLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHY 284
Query: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
+ + P +++ GF E ++++YF FG++ +A++ F +R N LF L P CW+VC
Sbjct: 285 FMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVC 344
Query: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQL------RGALRTLSLLAAQGLW 424
T +K ++E+GED T L+ FL + F G+Q R L++L LAA+G+W
Sbjct: 345 TCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIW 404
Query: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
VF DL R G+ ES+ +++ +L++ C++F+HL Q+F A+FY L++
Sbjct: 405 TYTFVFSHGDLRRNGLSESEGVMWVGMRLLQR---RGDCFAFMHLCIQEFCAAMFYLLKR 461
Query: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
+ + IG + +L+ L QVG F+FG++ E+ LE +FG +S
Sbjct: 462 PKDDPNPA----IGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSK 517
Query: 545 DIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
D+KQE+ QC L +E+ L+E+QE+E V+ F+E+ I++ N
Sbjct: 518 DLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEH 577
Query: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLEN---YMDFELDIEFERCTYLTIPNWARQDLRS 660
++ SF LKHCQ L L + V + +F ++ D+ E+ Y
Sbjct: 578 LVIASFCLKHCQHLTTLRMCV-ENIFPDDSGCISDYN-----EKLVY------------- 618
Query: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
W + CS+F +N N + L+++ + L D S+ ILC + + C L+K+ +V
Sbjct: 619 ---WRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDS 675
Query: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
F A + L L+L G ++ + LC+ L++ C ++ L LG + E +
Sbjct: 676 ELF-KAVLHNPHLKLLSLYG-TSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCED 733
Query: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
VL N LKHL L N L DEG LL + + L+ L L C LT SC ++
Sbjct: 734 IASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISE 793
Query: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
VL+ SK L+ L L N + D GV LC L +P C ++ L L C +T C+ ++ L
Sbjct: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
Query: 901 EACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQ 959
L L L N+I G+ LC AL++P+C L+ L L +C + C + +AL++ +
Sbjct: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
Query: 960 KLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLT 1019
L +L+L L ++ L L +L++L L + E +K+L V+EK P LT
Sbjct: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLT 973
Query: 1020 I 1020
I
Sbjct: 974 I 974
Score = 97.8 bits (242), Expect = 5e-20
Identities = 76/257 (29%), Positives = 117/257 (45%), Gaps = 10/257 (3%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRD-FC 724
D S+ + NS LK L + ++ L D + +LC+ + S C L+++ + + D
Sbjct: 733 DIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSIS 792
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
+ K+L+ L L G E + LC L++ C+++ L L G T + + V
Sbjct: 793 EVLLCSKSLSLLDL-GSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAV 851
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N LK L+L N + D G L + P L+ L L+ C +T A C D+AA L+
Sbjct: 852 LICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIA 911
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACS 904
K L L L + V LCE LS+PDC LQ L L + + + L ++
Sbjct: 912 CKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPH 971
Query: 905 LTNLDLSINQIARGLWI 921
LT I+ G WI
Sbjct: 972 LT--------ISHGPWI 980
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 444 bits (1142), Expect = e-124
Identities = 343/1062 (32%), Positives = 506/1062 (47%), Gaps = 62/1062 (5%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L T LE+L ELK FK L E K PW +E+A ++A++L+
Sbjct: 13 LSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWR 71
Query: 70 ATVNILEEMNLTELCKMAKAE-MMED---GQVQEIDNPELGDAEEDSELAKPGEKEGWRN 125
++ E +N +L + + E ++ D G + N E + +E +R+
Sbjct: 72 LALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRD 131
Query: 126 SMEKQ-SLVWKNTFWQGDIDNF------------HDDVTLRNQRFIP------------- 159
+ ++ L+ G+ N H + Q+ +
Sbjct: 132 YVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQA 191
Query: 160 -------FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLS 211
P R P TVV+ G AG+GK+ LA K MLDW D L Y FY++
Sbjct: 192 SPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYIN 251
Query: 212 CKELSRMGP-CSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDIC 270
C+E+++ CS +LI WPE + ++ +R+LF++DG DELK C
Sbjct: 252 CREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWC 311
Query: 271 GDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRR 330
WE+K+P +LL SL+++K+LP +LL+TTRP AL L L + P +V + GF E +R+
Sbjct: 312 LCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERK 371
Query: 331 AYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTR 390
YF ++F + +QA + F +R N LF + P VCW+VCT L+ Q+E G T T
Sbjct: 372 EYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTT 431
Query: 391 TGLFLRFLCSRF---PQGAQLRGA--LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDL 445
T +++ +L S P +L+ R L LAA GLW Q +F +DL + G+ D+
Sbjct: 432 TAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
Query: 446 RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS 505
FL+ +I ++D + YSFIHLSFQ+F A++Y L +EGE G A DV +LL+
Sbjct: 492 SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYIL--DEGE---GGAGPDQDVTRLLT 546
Query: 506 GEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQ-CKAHLHANKPLS 564
+ L FLFGL NE+ LE + ++SP IK +LLQ ++ ++
Sbjct: 547 EYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTL 606
Query: 565 VTDLKEVLGCLYESQEEELAKVVVAPFKEISI-HLTNTSEVMHCSFSLKHCQDLQKLSLQ 623
E CLYE QEEE + ++ F+ I + ++ + E M SF LK C+ Q L L
Sbjct: 607 QQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLY 666
Query: 624 VAKGVFLENYMDFELDIEFERCTYLTIP-NWARQDLRSLRLWTDFCSLFSSNSNLKFLEV 682
A + + D + +P D S L C +N NL L +
Sbjct: 667 GA--TYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALC----TNPNLIELSL 720
Query: 683 KQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGH 741
++ L V++LC + C LQ + +K +A D A I K LT + L+G+
Sbjct: 721 YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN 780
Query: 742 IEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVL 801
MML LC+ LR+ +C LQ ++L E VL N L L L+ N L
Sbjct: 781 GVGFPGMML-LCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL 839
Query: 802 LDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDT 861
D G LL + + P L+ L L+ CRLT A+C +LA+ L V++ L L L+ N +GD
Sbjct: 840 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL 899
Query: 862 GVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLW 920
GV LCEGL +P CKLQTL L C + C LS LQ +L LDLS N + GLW
Sbjct: 900 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW 959
Query: 921 ILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLF 980
+L + L++P C L+ L L SC L C++L L NQ L L L N L +G+ L
Sbjct: 960 LLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLC 1019
Query: 981 GVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDC 1022
L L++L L + N L ++ P L I C
Sbjct: 1020 KRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC 1061
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 433 bits (1114), Expect = e-121
Identities = 342/1071 (31%), Positives = 511/1071 (47%), Gaps = 110/1071 (10%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDIG--DVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 QCKAHLHANKPLSVTDLK-EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ K L + + E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670
+++C ++ LSL FL N M E + E + +L + C L
Sbjct: 670 IENCHRVESLSLG-----FLHN-MPKEEEEEEKEGRHLDMVQ---------------CVL 708
Query: 671 FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730
SS+ + S ++ H+T S C R
Sbjct: 709 PSSSH------------AACSHGLVNSHLTSSFC----------------RGLFSVLSTS 740
Query: 731 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790
++LT L L+ + + M + LC+ L++ CN++ L LG + E + VL +NQ
Sbjct: 741 QSLTELDLSDNSLGDPGMRV-LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
L L LS N L D G LL + L+ L L +C LT A C+DLA+VL S LT
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
Query: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 910
L + +N +GD+GV LCE P C LQ L L +T + C LS L +LT+L L
Sbjct: 860 LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
Query: 911 SINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQN 969
N + +G+ +LC+ L +P+C L+ L L +C+L C L + L S+Q L L LG N
Sbjct: 920 RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
Query: 970 HLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
L G++ VL+Q++ L+ L L N E K LE ++E+ P+LT+
Sbjct: 980 DLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 433 bits (1114), Expect = e-121
Identities = 342/1071 (31%), Positives = 511/1071 (47%), Gaps = 110/1071 (10%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDIG--DVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 QCKAHLHANKPLSVTDLK-EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ K L + + E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670
+++C ++ LSL FL N M E + E + +L + C L
Sbjct: 670 IENCHRVESLSLG-----FLHN-MPKEEEEEEKEGRHLDMVQ---------------CVL 708
Query: 671 FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730
SS+ + S ++ H+T S C R
Sbjct: 709 PSSSH------------AACSHGLVNSHLTSSFC----------------RGLFSVLSTS 740
Query: 731 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790
++LT L L+ + + M + LC+ L++ CN++ L LG + E + VL +NQ
Sbjct: 741 QSLTELDLSDNSLGDPGMRV-LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
L L LS N L D G LL + L+ L L +C LT A C+DLA+VL S LT
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
Query: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 910
L + +N +GD+GV LCE P C LQ L L +T + C LS L +LT+L L
Sbjct: 860 LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
Query: 911 SINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQN 969
N + +G+ +LC+ L +P+C L+ L L +C+L C L + L S+Q L L LG N
Sbjct: 920 RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
Query: 970 HLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
L G++ VL+Q++ L+ L L N E K LE ++E+ P+LT+
Sbjct: 980 DLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 421 bits (1083), Expect = e-117
Identities = 315/1065 (29%), Positives = 507/1065 (47%), Gaps = 105/1065 (9%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
LQ L +L+++E ++FK LL E P E+E A+ + LA +L +
Sbjct: 65 LQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWA 124
Query: 70 ATVNILEEMNLTELCKMAKAEMM----EDGQVQEIDN-------PELGDA-EEDS----- 112
+++I E MNL L + A+ +M ED + D P + A ++DS
Sbjct: 125 TSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAE 184
Query: 113 ----ELAKPGEKEGWR----------NSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFI 158
E+++ E+EG +ME++ T QG + D + +F
Sbjct: 185 TKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFA 244
Query: 159 PFLNPRTPRKLT----------------------PYTVVLHGPAGVGKTTLAKKCMLDWT 196
+ R + T P TVVLHG +G+GK+ LA++ +L W
Sbjct: 245 EEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWA 304
Query: 197 DCNLSPTL-RYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGL 255
L + Y F+L +E+ R S E IS++WP+ Q + I+++ +R+LF++DG
Sbjct: 305 QGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGF 364
Query: 256 DELKVPPGALIQD---ICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLL 312
D+L G+++ + +C DW +K+P L+ SLL++ +LP + L+VT R L+
Sbjct: 365 DDL----GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSE 420
Query: 313 AQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTT 372
P Y+ V G E R L E Q + + +N L PAV ++C
Sbjct: 421 VVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVA 480
Query: 373 LKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-------QLRGALRTLSLLAAQGLW 424
L+LQ GE P T TGL F+ + P+G + R L+ +A +G+W
Sbjct: 481 LQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW 540
Query: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
+ SVF +DL G+ ES+LR +IL D + Y+F HLS Q F AL+Y LE
Sbjct: 541 NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEG 600
Query: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVG---------HFLFGLANEKRAKELE 535
E I L E+ ++ +L Q G FLFGL +E + LE
Sbjct: 601 LE----------IEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLE 650
Query: 536 ATFGCRMSPDIKQELLQCKAHLHANKPLSVT--DLKEVLGCLYESQEEELAKVVVAPFKE 593
GC + +KQ+LL + L +P + T D + CL+E+Q++E ++ + F+E
Sbjct: 651 VLLGCPVPLGVKQKLLHWVSLL-GQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQE 709
Query: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNW 653
+ + + +++ SF L+HC L+K+ + V KG+F D E C +P W
Sbjct: 710 VWLPINQNLDLIASSFCLQHCPYLRKIRVDV-KGIFPR-------DESAEACP--VVPLW 759
Query: 654 ARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKN 713
R W DFCS+ ++ +L+ L++ S L++ +++ LC + TC +Q + +N
Sbjct: 760 MRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRN 819
Query: 714 VTPDTAYRDFCLAFIGKKTLTHLTLAG-HIEWERTMMLMLCDLLRNHKCNLQYLRLGGHC 772
+ + + L L L G H++ E M C+ L++ KC L+ LRL
Sbjct: 820 AQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMA--CEALKHPKCLLESLRLDCCG 877
Query: 773 ATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTE 832
T + + +L + SLK L L+ N + D+G M L + + LQ L LE+C +T
Sbjct: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
Query: 833 ASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGC 892
C+ LA+ LV ++ LTHLCL+ N +G+ GV LC + P C LQ L+L QC + GC
Sbjct: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
Query: 893 RYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHL 951
+L+ AL LT+L LS+N + G+ +LC+ + P+C+L+ L L C L C+ L
Sbjct: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESL 1057
Query: 952 GSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLK 996
+ ++ L++LDL N L G+ L L+Q+ L L LK
Sbjct: 1058 SCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLK 1102
Score = 124 bits (312), Expect = 4e-28
Identities = 101/296 (34%), Positives = 141/296 (47%), Gaps = 18/296 (6%)
Query: 658 LRSLRLWTDFCSL-----------FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHL 706
L SLRL D C L +++ +LK L + + ++D V L D + S C L
Sbjct: 868 LESLRL--DCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCAL 925
Query: 707 QKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQY 765
QK+ +++ T + A + ++LTHL L+ + + L LC +R C+LQ
Sbjct: 926 QKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNL-LCRSMRLPHCSLQR 984
Query: 766 LRLGGHCATPEQWAEFFYV-LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLS 824
L L C F + L N L HL LS N + D G LL + M P LQ L
Sbjct: 985 LMLN-QCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLE 1043
Query: 825 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 884
L C LT A C+ L+ V+ S+ L L L N +GD GV LCEGL + L L L+
Sbjct: 1044 LVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKA 1103
Query: 885 CSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLW 939
C +T C LS AL LT+L+L N + +G+ LC A P NL+ + LW
Sbjct: 1104 CGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLW 1159
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 394 bits (1012), Expect = e-109
Identities = 312/989 (31%), Positives = 458/989 (46%), Gaps = 110/989 (11%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDIG--DVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 QCKAHLHANKPLSVTDLK-EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ K L + + E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670
+++C ++ LSL FL N E + E E
Sbjct: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEG-------------------------- 698
Query: 671 FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730
+ L++ Q L SS C H C L D L
Sbjct: 699 -------RHLDMVQCVLPSSS-HAACSHGL-GRCGLSH---------ECCFDISLVLSSN 740
Query: 731 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790
+ L L L+ + + + L LC L++ CNL+ L L C T + VL + S
Sbjct: 741 QKLVELDLSDNALGDFGIRL-LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHS 799
Query: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
L L + N L D G +L + P+ LQ L L N LT C L++VL ++ LTH
Sbjct: 800 LTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTH 859
Query: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 910
L L N +GD G+K LCEGL +PDCKLQ L L C++T C LS L + SL L L
Sbjct: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919
Query: 911 SINQIA-RGLWILCQALENPNCNLKHLRL 938
N + G+ + C+ L+ +C L++L L
Sbjct: 920 GNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
Score = 147 bits (370), Expect = 7e-35
Identities = 93/238 (39%), Positives = 130/238 (54%), Gaps = 1/238 (0%)
Query: 784 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 843
VL +NQ L L LS N L D G LL + L+ L L +C LT A C+DLA+VL
Sbjct: 736 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 795
Query: 844 VSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEAC 903
S LT L + +N +GD+GV LCE P C LQ L L +T + C LS L
Sbjct: 796 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 855
Query: 904 SLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLE 962
+LT+L L N + +G+ +LC+ L +P+C L+ L L +C+L C L + L S+Q L
Sbjct: 856 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 915
Query: 963 TLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
L LG N L G++ VL+Q++ L+ L L N E K LE ++E+ P+LT+
Sbjct: 916 KLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
Score = 97.8 bits (242), Expect = 5e-20
Identities = 63/172 (36%), Positives = 88/172 (51%), Gaps = 1/172 (0%)
Query: 825 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 884
L C L+ C D++ VL ++KL L L+ N +GD G++ LC GL + C L+ L L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
Query: 885 CSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSL 943
C +T C+ L+ L + SLT L + N + G+ ILC+ +NP CNL+ L L + L
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
Query: 944 MPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 995
C L S L +NQ L L L N L GI L L L++L L
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 891
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 392 bits (1008), Expect = e-109
Identities = 314/989 (31%), Positives = 467/989 (47%), Gaps = 110/989 (11%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDIG--DVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 QCKAHLHANKPLSVTDLK-EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ K L + + E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670
+++C ++ LSL FL N M E + E + +L + C L
Sbjct: 670 IENCHRVESLSLG-----FLHN-MPKEEEEEEKEGRHLDMVQ---------------CVL 708
Query: 671 FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730
SS+ + S ++ H+T S C R
Sbjct: 709 PSSSH------------AACSHGLVNSHLTSSFC----------------RGLFSVLSTS 740
Query: 731 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790
++LT L L+ + + M + LC+ L++ CN++ L LG + E + VL +NQ
Sbjct: 741 QSLTELDLSDNSLGDPGMRV-LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
L L LS N L D G LL + L+ L L N LT C L++VL ++ LTH
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTH 859
Query: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 910
L L N +GD G+K LCEGL +PDCKLQ L L C++T C LS L + SL L L
Sbjct: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919
Query: 911 SINQIA-RGLWILCQALENPNCNLKHLRL 938
N + G+ + C+ L+ +C L++L L
Sbjct: 920 GNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
Score = 142 bits (357), Expect = 2e-33
Identities = 88/240 (36%), Positives = 132/240 (55%), Gaps = 1/240 (0%)
Query: 782 FYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAV 841
F VL +QSL L LS N L D G +L +T+ P ++ L L C L+ C D++ V
Sbjct: 734 FSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLV 793
Query: 842 LVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQE 901
L ++KL L L+ N +GD G++ LC GL + C L+ L L +T + C LS L
Sbjct: 794 LSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLST 853
Query: 902 ACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 960
+LT+L L N + +G+ +LC+ L +P+C L+ L L +C+L C L + L S+Q
Sbjct: 854 NQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQS 913
Query: 961 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
L L LG N L G++ VL+Q++ L+ L L N E K LE ++E+ P+LT+
Sbjct: 914 LRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 360 bits (925), Expect = 3e-99
Identities = 297/1030 (28%), Positives = 464/1030 (45%), Gaps = 71/1030 (6%)
Query: 3 SPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTS 62
S ++ L LE L++ E +SFK L L+ L + P ++ + ++LA +L +
Sbjct: 4 SDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTK---EELANVLPISY 60
Query: 63 SENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEG 122
+I N +I M +LC+ +G + E K +
Sbjct: 61 EGQYIWNMLFSIFSMMRKEDLCRKI-----------------IGRRNRNQEACKAVMRR- 102
Query: 123 WRNSMEKQSLVWKN-TFWQGDIDNFHD---DVTLRNQRFIPFLNPRTPRKLTPYTVVLHG 178
K L W++ TF + F D DV Q + + L V L G
Sbjct: 103 ------KFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLN---VFLMG 153
Query: 179 PAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDD 237
GKT + +L W + + Y +L+ E+++M S AELI+KDWP+ Q
Sbjct: 154 ERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAP 213
Query: 238 IPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAAL 297
I IL+ +++LF+++ LD ++ +C + +K P+PVLL SLLKRKM P
Sbjct: 214 IADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWF 273
Query: 298 LVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALF 357
L+++RP +++ ++ R YF F D +A A +L+ + L
Sbjct: 274 LISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILV 333
Query: 358 QLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLR------GA 411
L +CWI CT LK QM+KG D C T T L FL A L G
Sbjct: 334 GLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGL 393
Query: 412 LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSF 471
L+ L LLAA GL+ F EDL +G E+D+ + +IL K Y FIHL+
Sbjct: 394 LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNV 453
Query: 472 QQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRA 531
Q+F TA+ + + G E+R + D QV F+FGL N R
Sbjct: 454 QEFCTAIAFLMAVPNYLIPSG---------SREYKEKREQYSDFNQVFTFIFGLLNANRR 504
Query: 532 KELEATFGCR--MSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVA 589
K LE +FG + M K + HL + P +T + CLYE++EEE K +V
Sbjct: 505 KILETSFGYQLPMVDSFKWYSVGYMKHLDRD-PEKLTHHMPLFYCLYENREEEFVKTIVD 563
Query: 590 PFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLT 649
E++++L + ++M + L +C L+ L L V + F+ L
Sbjct: 564 ALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQR--------------IFQNKEPLI 609
Query: 650 IPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKV 709
P ++SL W + CSLF + +L+ L + + L+ S RIL + S+C L+ +
Sbjct: 610 RP--TASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTL 667
Query: 710 EIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLG 769
++ V+ + + D A ++LT+L++ M +L D+L C + +L L
Sbjct: 668 KLSYVSTASGFEDLLKALARNRSLTYLSI-NCTSISLNMFSLLHDILHEPTCQISHLSLM 726
Query: 770 GHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCR 829
+ E +L + SL+ L LS+N L +G +L + P L L L C
Sbjct: 727 KCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCC 786
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
LTE C L VL+ S L L L N + + GV + L +P C+L+ L L C +
Sbjct: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948
C+Y++ + L +L++ N+I G+ +LC L +PNC L ++ L C L C
Sbjct: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACC 906
Query: 949 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLL 1008
+ L S L +N+ LE L+L QNHL G+ KL L LK++ L N + ++LL
Sbjct: 907 RSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLL 966
Query: 1009 EEVKEKNPKL 1018
VKE+ P L
Sbjct: 967 MTVKERKPSL 976
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 359 bits (922), Expect = 7e-99
Identities = 292/934 (31%), Positives = 426/934 (45%), Gaps = 109/934 (11%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDIG--DVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 QCKAHLHANKPLSVTDLK-EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ K L + + E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670
+++C ++ LSL FL N E + E E
Sbjct: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEG-------------------------- 698
Query: 671 FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730
+ L++ Q L SS C H C L D L
Sbjct: 699 -------RHLDMVQCVLPSSS-HAACSHGL-GRCGLSH---------ECCFDISLVLSSN 740
Query: 731 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790
+ L L L+ + + + L LC L++ CNL+ L L T + VL NQ+
Sbjct: 741 QKLVELDLSDNALGDFGIRL-LCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQN 799
Query: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
L HL L N L D+G LL + + P LQ+L L+NC LT C DL+ +L S+ L
Sbjct: 800 LTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRK 859
Query: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 884
L L N +GD GV CE L C LQ L L +
Sbjct: 860 LSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 893
Score = 119 bits (299), Expect = 1e-26
Identities = 71/197 (36%), Positives = 109/197 (55%), Gaps = 1/197 (0%)
Query: 825 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 884
L C L+ C D++ VL ++KL L L+ N +GD G++ LC GL + C L+ L L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 885 CSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSL 943
+T + C LS L +LT+L L N + +G+ +LC+ L +P+C L+ L L +C+L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 944 MPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLE 1003
C L + L S+Q L L LG N L G++ VL+Q++ L+ L L N E
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYE 899
Query: 1004 IKKLLEEVKEKNPKLTI 1020
K LE ++E+ P+LT+
Sbjct: 900 TKSALETLQEEKPELTV 916
Score = 106 bits (264), Expect = 1e-22
Identities = 65/156 (41%), Positives = 86/156 (55%), Gaps = 1/156 (0%)
Query: 784 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 843
VL +NQ L L LS N L D G LL + L+ L L N LT C L++VL
Sbjct: 736 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLS 795
Query: 844 VSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEAC 903
++ LTHL L N +GD G+K LCEGL +PDCKLQ L L C++T C LS L +
Sbjct: 796 TNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQ 855
Query: 904 SLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
SL L L N + G+ + C+ L+ +C L++L L
Sbjct: 856 SLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 316 bits (809), Expect = 8e-86
Identities = 251/743 (33%), Positives = 362/743 (48%), Gaps = 107/743 (14%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMG--------------------------------- 742
Query: 629 FLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSN-SNLKFLEVKQSFL 687
M E D+E CT FC FS + L+ +E +Q
Sbjct: 743 -----MCVETDMELLVCT--------------------FCIKFSRHVKKLQLIEGRQH-- 775
Query: 688 SDSSVRILCDHVTRSTCHLQKVEIKNVTPDT-AYRDFCLAFIG-KKTLTHLTLAGHIEWE 745
RST V + P T AY + + + L L L+G+
Sbjct: 776 -------------RSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGN-SLS 821
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
+ + LC LR +C L+ LRL G T E + + L+ANQ+L L LS NVL D G
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAG 881
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
A L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+
Sbjct: 882 AKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRL 941
Query: 866 LCEGLSYPDCKLQTLVLQQCSIT 888
LCEGL +P CKL L L Q +++
Sbjct: 942 LCEGLRHPACKLIRLGLDQTTLS 964
Score = 113 bits (282), Expect = 1e-24
Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 1/166 (0%)
Query: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRL 938
L+ L + SL LDL N + G+ +LC+ L +P C L L L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 105 bits (263), Expect = 2e-22
Identities = 72/194 (37%), Positives = 109/194 (56%), Gaps = 5/194 (2%)
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 949 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNL--EIKK 1006
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL +T L E+++
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRLGLDQTTLSDEMRQ 969
Query: 1007 LLEEVKEKNPKLTI 1020
L ++++ P+L I
Sbjct: 970 ELRALEQEKPQLLI 983
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 316 bits (809), Expect = 8e-86
Identities = 251/743 (33%), Positives = 362/743 (48%), Gaps = 107/743 (14%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMG--------------------------------- 742
Query: 629 FLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSN-SNLKFLEVKQSFL 687
M E D+E CT FC FS + L+ +E +Q
Sbjct: 743 -----MCVETDMELLVCT--------------------FCIKFSRHVKKLQLIEGRQH-- 775
Query: 688 SDSSVRILCDHVTRSTCHLQKVEIKNVTPDT-AYRDFCLAFIG-KKTLTHLTLAGHIEWE 745
RST V + P T AY + + + L L L+G+
Sbjct: 776 -------------RSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGN-SLS 821
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
+ + LC LR +C L+ LRL G T E + + L+ANQ+L L LS NVL D G
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAG 881
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
A L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+
Sbjct: 882 AKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRL 941
Query: 866 LCEGLSYPDCKLQTLVLQQCSIT 888
LCEGL +P CKL L L Q +++
Sbjct: 942 LCEGLRHPACKLIRLGLDQTTLS 964
Score = 113 bits (282), Expect = 1e-24
Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 1/166 (0%)
Query: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRL 938
L+ L + SL LDL N + G+ +LC+ L +P C L L L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 105 bits (263), Expect = 2e-22
Identities = 72/194 (37%), Positives = 109/194 (56%), Gaps = 5/194 (2%)
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 949 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNL--EIKK 1006
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL +T L E+++
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRLGLDQTTLSDEMRQ 969
Query: 1007 LLEEVKEKNPKLTI 1020
L ++++ P+L I
Sbjct: 970 ELRALEQEKPQLLI 983
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 316 bits (809), Expect = 8e-86
Identities = 251/743 (33%), Positives = 362/743 (48%), Gaps = 107/743 (14%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMG--------------------------------- 742
Query: 629 FLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSN-SNLKFLEVKQSFL 687
M E D+E CT FC FS + L+ +E +Q
Sbjct: 743 -----MCVETDMELLVCT--------------------FCIKFSRHVKKLQLIEGRQH-- 775
Query: 688 SDSSVRILCDHVTRSTCHLQKVEIKNVTPDT-AYRDFCLAFIG-KKTLTHLTLAGHIEWE 745
RST V + P T AY + + + L L L+G+
Sbjct: 776 -------------RSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGN-SLS 821
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
+ + LC LR +C L+ LRL G T E + + L+ANQ+L L LS NVL D G
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAG 881
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
A L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+
Sbjct: 882 AKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRL 941
Query: 866 LCEGLSYPDCKLQTLVLQQCSIT 888
LCEGL +P CKL L L Q +++
Sbjct: 942 LCEGLRHPACKLIRLGLDQTTLS 964
Score = 113 bits (282), Expect = 1e-24
Identities = 68/166 (40%), Positives = 87/166 (52%), Gaps = 1/166 (0%)
Query: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRL 938
L+ L + SL LDL N + G+ +LC+ L +P C L L L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 105 bits (263), Expect = 2e-22
Identities = 72/194 (37%), Positives = 109/194 (56%), Gaps = 5/194 (2%)
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 949 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNL--EIKK 1006
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL +T L E+++
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRLGLDQTTLSDEMRQ 969
Query: 1007 LLEEVKEKNPKLTI 1020
L ++++ P+L I
Sbjct: 970 ELRALEQEKPQLLI 983
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 312 bits (800), Expect = 9e-85
Identities = 248/732 (33%), Positives = 356/732 (48%), Gaps = 107/732 (14%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMG--------------------------------- 742
Query: 629 FLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSN-SNLKFLEVKQSFL 687
M E D+E CT FC FS + L+ +E +Q
Sbjct: 743 -----MCVETDMELLVCT--------------------FCIKFSRHVKKLQLIEGRQH-- 775
Query: 688 SDSSVRILCDHVTRSTCHLQKVEIKNVTPDT-AYRDFCLAFIG-KKTLTHLTLAGHIEWE 745
RST V + P T AY + + + L L L+G+
Sbjct: 776 -------------RSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGN-SLS 821
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
+ + LC LR +C L+ LRL G T E + + L+ANQ+L L LS NVL D G
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAG 881
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
A L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+
Sbjct: 882 AKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRL 941
Query: 866 LCEGLSYPDCKL 877
LCEGL +P CKL
Sbjct: 942 LCEGLRHPACKL 953
Score = 113 bits (282), Expect = 1e-24
Identities = 70/172 (40%), Positives = 91/172 (52%), Gaps = 3/172 (1%)
Query: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLM 944
L+ L + SL LDL N + G+ +LC+ L +P C L +RL S+M
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLGKPSVM 962
Score = 97.8 bits (242), Expect = 5e-20
Identities = 65/167 (38%), Positives = 93/167 (55%), Gaps = 3/167 (1%)
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 949 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 995
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRL 956
Score = 53.9 bits (128), Expect = 8e-07
Identities = 48/156 (30%), Positives = 71/156 (45%), Gaps = 3/156 (1%)
Query: 866 LCEGLSYPDCKLQTLVL--QQCSITKLGCRYLSEALQEACSLTNLDLSINQIARG-LWIL 922
L EG + T+V+ + +T + L L+ +L LDLS N ++ + L
Sbjct: 769 LIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL 828
Query: 923 CQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGV 982
C+ L P C L+ LRL C L C+ L L +NQ L LDL N L +G L
Sbjct: 829 CKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQR 888
Query: 983 LRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKL 1018
LRQ + L+ L+L + + + L V +P L
Sbjct: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 312 bits (800), Expect = 9e-85
Identities = 248/732 (33%), Positives = 356/732 (48%), Gaps = 107/732 (14%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMG--------------------------------- 742
Query: 629 FLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSN-SNLKFLEVKQSFL 687
M E D+E CT FC FS + L+ +E +Q
Sbjct: 743 -----MCVETDMELLVCT--------------------FCIKFSRHVKKLQLIEGRQH-- 775
Query: 688 SDSSVRILCDHVTRSTCHLQKVEIKNVTPDT-AYRDFCLAFIG-KKTLTHLTLAGHIEWE 745
RST V + P T AY + + + L L L+G+
Sbjct: 776 -------------RSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGN-SLS 821
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
+ + LC LR +C L+ LRL G T E + + L+ANQ+L L LS NVL D G
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAG 881
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
A L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+
Sbjct: 882 AKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRL 941
Query: 866 LCEGLSYPDCKL 877
LCEGL +P CKL
Sbjct: 942 LCEGLRHPACKL 953
Score = 113 bits (282), Expect = 1e-24
Identities = 70/172 (40%), Positives = 91/172 (52%), Gaps = 3/172 (1%)
Query: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLM 944
L+ L + SL LDL N + G+ +LC+ L +P C L +RL S+M
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL--IRLGKPSVM 962
Score = 97.8 bits (242), Expect = 5e-20
Identities = 65/167 (38%), Positives = 93/167 (55%), Gaps = 3/167 (1%)
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYC 948
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L SC L C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 949 QHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 995
Q L S L ++ L+ LDL QN+L G+ L LR + K++RL
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH--PACKLIRL 956
Score = 53.9 bits (128), Expect = 8e-07
Identities = 48/156 (30%), Positives = 71/156 (45%), Gaps = 3/156 (1%)
Query: 866 LCEGLSYPDCKLQTLVL--QQCSITKLGCRYLSEALQEACSLTNLDLSINQIARG-LWIL 922
L EG + T+V+ + +T + L L+ +L LDLS N ++ + L
Sbjct: 769 LIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL 828
Query: 923 CQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGV 982
C+ L P C L+ LRL C L C+ L L +NQ L LDL N L +G L
Sbjct: 829 CKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQR 888
Query: 983 LRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKL 1018
LRQ + L+ L+L + + + L V +P L
Sbjct: 889 LRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSL 924
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 244 bits (623), Expect = 3e-64
Identities = 225/726 (30%), Positives = 325/726 (44%), Gaps = 77/726 (10%)
Query: 171 PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL-SRMGPCSFAELIS 228
P TVVL GPAG+GKT AKK + DW L + +AF++ C EL R G S A+LI
Sbjct: 195 PLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLIL 254
Query: 229 KDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLK 288
P+ +P +LAQ QR+LF++DG DEL G +E VL G LL
Sbjct: 255 DQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVL-GGLLS 313
Query: 289 RKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFE 348
+ +LP A LLVTTR A LQ P V GF ++D++ YF + F DE +A RA+
Sbjct: 314 KALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYR 373
Query: 349 LMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCS-----RFP 403
++ N LF L P VCWIVCT L+ Q+E G D T T T ++L F+ S
Sbjct: 374 FVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVA 433
Query: 404 QGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLR-LFLDGDILRQDRVSKG 462
G +L+G LR L LA +G+ + + F ++LE+L ++ S ++ LFL L ++
Sbjct: 434 DGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEV 493
Query: 463 CYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFL 522
Y FI SFQ+FL AL Y LE + G R G V LL G+ + + L+ FL
Sbjct: 494 TYQFIDQSFQEFLAALSYLLE-DGGVPRTA----AGGVGTLLRGDAQ-PHSHLVLTTRFL 547
Query: 523 FGLANEKRAKELEATFGCRMSPDIKQELLQ------------CKAHLHANKPLSVTDLK- 569
FGL + +R +++E FGC +S +KQE L+ K L T+
Sbjct: 548 FGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPE 607
Query: 570 ------------EVLGCLYESQEEELAKVVVAPFKEISIHLTN--TSEVMHCSFSLKHCQ 615
E+L CLYE+QE+ + + F E+++ +V S+ ++ C
Sbjct: 608 EEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCP 667
Query: 616 DLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNS 675
Q L L C + ++ L RL SS
Sbjct: 668 AGQALRL--------------------ISCRLVAAQEKKKKSL-GKRLQASLGGGSSSQG 706
Query: 676 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLT 734
K L S + L +T CHL + + + PD RD A LT
Sbjct: 707 TTKQLPA-------SLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALT 759
Query: 735 HLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFY-VLKANQSLKH 793
L L H + ML + L +C +Q +R+ P++ ++ +L+ + +L
Sbjct: 760 ELGLL-HNRLSEAGLRMLSEGLAWPQCRVQTVRV--QLPDPQRGLQYLVGMLRQSPALTT 816
Query: 794 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKL--THL 851
L LS L L + LQ LSL + L+E S ++L AV L TH
Sbjct: 817 LDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHP 876
Query: 852 CLAKNP 857
L +P
Sbjct: 877 ALDGHP 882
Score = 84.0 bits (206), Expect = 7e-16
Identities = 53/144 (36%), Positives = 81/144 (56%), Gaps = 2/144 (1%)
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
L++ MT P L L+L +C+L +A C+DL+ L + LT L L N + + G++ L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL++P C++QT V Q + G +YL L+++ +LT LDLS Q+ A + LC L+
Sbjct: 779 GLAWPQCRVQT-VRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 928 NPNCNLKHLRLWSCSLMPFYCQHL 951
+ C L+ L L S L Q L
Sbjct: 838 HQGCGLQTLSLASVELSEQSLQEL 861
Score = 61.2 bits (147), Expect = 5e-09
Identities = 53/168 (31%), Positives = 80/168 (47%), Gaps = 3/168 (1%)
Query: 866 LCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQ 924
L + ++ P C L +L L C + CR LSEAL+ A +LT L L N+++ GL +L +
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 925 ALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLR 984
L P C ++ +R+ Q+L L + L TLDL L + L VL+
Sbjct: 779 GLAWPQCRVQTVRVQLPDPQRGL-QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 985 QRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTIDCNA-SGATAPP 1031
+ L+ L L + E + + + L+ VK P L I A G PP
Sbjct: 838 HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHPQPP 885
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 219 bits (557), Expect = 1e-56
Identities = 181/621 (29%), Positives = 287/621 (46%), Gaps = 52/621 (8%)
Query: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
L L E++ K K L L + E+E LAE+L++ E +
Sbjct: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
Query: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKE-----GWRNSME 128
L+ MNL EL + D +E+ + EE E G +S
Sbjct: 77 GLKVMNLLELVDQLSHICLHD--YREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSES 134
Query: 129 KQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLA 188
+SL F + ++++ VT+ + L P VVL G AG GKTTLA
Sbjct: 135 PESLACP--FPEQELES----VTVE-----ALFDSGEKPSLAPSLVVLQGSAGTGKTTLA 183
Query: 189 KKCMLDWTDCNLSP-TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQR 247
+K +LDW L P Y FY+SCKE+ + +L+ + Q + IL Q +R
Sbjct: 184 RKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPER 243
Query: 248 ILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALR 307
+LF++DG DEL+ P ++ P LL L++R LP +LL+TTRP ALR
Sbjct: 244 LLFILDGFDELQRPFEEKLKK-----RGLSPKESLLHLLIRRHTLPTCSLLITTRPLALR 298
Query: 308 DLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCW 367
+L+ L +Q +V + GF EE+R YF +F DE QA RAF++++ N L++ P +CW
Sbjct: 299 NLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICW 358
Query: 368 IVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP-------QGAQLRGALRTLSLLAA 420
+VC+ L+ QME+G+ + T T +F+ ++ + P LR+L LAA
Sbjct: 359 VVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAA 418
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
+G+ Q +F +L + + L FL + + K YSF H+SFQ F A+ Y
Sbjct: 419 EGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSY 478
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
+ +E + R G +VQ+LL +E+ N ++ FL ++ + LE F
Sbjct: 479 LV--KEDQSRLGKE-SRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCF 535
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
R+SP + Q+L K + + K DL+ LYE++ + L K +
Sbjct: 536 RISPCLAQDLKHFKEQMESMKHNRTWDLE---FSLYEAKIKNLVKGI------------- 579
Query: 601 TSEVMHCSFSLKHCQDLQKLS 621
++ + SF +KH + + S
Sbjct: 580 --QMNNVSFKIKHSNEKKSQS 598
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 145 bits (366), Expect = 2e-34
Identities = 102/359 (28%), Positives = 173/359 (48%), Gaps = 7/359 (1%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKL 961
L L +S N++ G+ LCQ L P L+ L L C + C L + LL+N L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 962 ETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
LDL N L +GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 987
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 988 GSLKIL 993
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 3e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 994
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 995 LKT 997
+K+
Sbjct: 320 VKS 322
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 145 bits (366), Expect = 2e-34
Identities = 102/359 (28%), Positives = 173/359 (48%), Gaps = 7/359 (1%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKL 961
L L +S N++ G+ LCQ L P L+ L L C + C L + LL+N L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 962 ETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
LDL N L +GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 987
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 988 GSLKIL 993
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 3e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 994
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 995 LKT 997
+K+
Sbjct: 320 VKS 322
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 145 bits (366), Expect = 2e-34
Identities = 102/359 (28%), Positives = 173/359 (48%), Gaps = 7/359 (1%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKL 961
L L +S N++ G+ LCQ L P L+ L L C + C L + LL+N L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 962 ETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
LDL N L +GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 987
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 988 GSLKIL 993
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 3e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 994
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 995 LKT 997
+K+
Sbjct: 320 VKS 322
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 145 bits (366), Expect = 2e-34
Identities = 102/359 (28%), Positives = 173/359 (48%), Gaps = 7/359 (1%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKL 961
L L +S N++ G+ LCQ L P L+ L L C + C L + LL+N L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 962 ETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
LDL N L +GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 987
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 988 GSLKIL 993
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 3e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 994
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 995 LKT 997
+K+
Sbjct: 320 VKS 322
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 145 bits (366), Expect = 2e-34
Identities = 102/359 (28%), Positives = 173/359 (48%), Gaps = 7/359 (1%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKL 961
L L +S N++ G+ LCQ L P L+ L L C + C L + LL+N L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 962 ETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
LDL N L +GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 987
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 988 GSLKIL 993
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 3e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 994
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 995 LKT 997
+K+
Sbjct: 320 VKS 322
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 145 bits (366), Expect = 2e-34
Identities = 102/359 (28%), Positives = 173/359 (48%), Gaps = 7/359 (1%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKL 961
L L +S N++ G+ LCQ L P L+ L L C + C L + LL+N L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Query: 962 ETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
LDL N L +GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 119 bits (299), Expect = 1e-26
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 987
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
Query: 988 GSLKIL 993
L+ L
Sbjct: 256 SRLRTL 261
Score = 118 bits (296), Expect = 3e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 994
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
Query: 995 LKT 997
+K+
Sbjct: 320 VKS 322
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,925,215
Number of Sequences: 37866
Number of extensions: 1780171
Number of successful extensions: 5501
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 4677
Number of HSP's gapped (non-prelim): 283
length of query: 1037
length of database: 18,247,518
effective HSP length: 112
effective length of query: 925
effective length of database: 14,006,526
effective search space: 12956036550
effective search space used: 12956036550
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.