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Search of human proteins with 113204615
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
(5038 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 1.018e+04 0.0
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 1.017e+04 0.0
gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens] 6623 0.0
gi|126032338 ryanodine receptor 3 [Homo sapiens] 4771 0.0
gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo s... 167 2e-40
gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isofor... 166 7e-40
gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isofor... 166 7e-40
gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo ... 161 2e-38
gi|17975763 myelin transcription factor 1 [Homo sapiens] 78 2e-13
gi|37588869 ring finger protein 123 [Homo sapiens] 71 3e-11
gi|45387949 ring finger and SPRY domain containing 1 [Homo sapiens] 69 2e-10
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 67 4e-10
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 67 4e-10
gi|169210053 PREDICTED: hypothetical protein [Homo sapiens] 66 8e-10
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens] 62 1e-08
gi|148839339 nexilin (F actin binding protein) [Homo sapiens] 62 1e-08
gi|189409130 zinc finger E-box binding homeobox 1 isoform a [Hom... 60 4e-08
gi|189409128 zinc finger E-box binding homeobox 1 isoform b [Hom... 60 4e-08
gi|22749303 hypothetical protein LOC196477 [Homo sapiens] 60 4e-08
gi|221219020 NYD-SP11 protein [Homo sapiens] 60 7e-08
gi|4508005 tripartite motif-containing 26 [Homo sapiens] 59 9e-08
gi|21735569 claspin [Homo sapiens] 59 2e-07
gi|148746195 trichohyalin [Homo sapiens] 59 2e-07
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)... 58 2e-07
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens] 58 2e-07
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens] 58 2e-07
gi|60498973 myelin transcription factor 1-like [Homo sapiens] 58 3e-07
gi|21735415 centromere protein B [Homo sapiens] 57 4e-07
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 57 4e-07
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 57 4e-07
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 1.018e+04 bits (26426), Expect = 0.0
Identities = 5038/5038 (100%), Positives = 5038/5038 (100%)
Query: 1 MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD 60
MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
Sbjct: 1 MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD 60
Query: 61 LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120
LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL
Sbjct: 61 LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120
Query: 121 TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180
TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH
Sbjct: 121 TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180
Query: 181 LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ 240
LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ
Sbjct: 181 LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ 240
Query: 241 RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV 300
RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV
Sbjct: 241 RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV 300
Query: 301 VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA 360
VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA
Sbjct: 301 VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA 360
Query: 361 PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420
PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF
Sbjct: 361 PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420
Query: 421 SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480
SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE
Sbjct: 421 SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480
Query: 481 GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS 540
GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS
Sbjct: 481 GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS 540
Query: 541 TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD 600
TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD
Sbjct: 541 TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD 600
Query: 601 VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK 660
VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK
Sbjct: 601 VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK 660
Query: 661 WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL 720
WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL
Sbjct: 661 WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL 720
Query: 721 WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV 780
WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV
Sbjct: 721 WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV 780
Query: 781 SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG 840
SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG
Sbjct: 781 SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG 840
Query: 841 PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK 900
PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK
Sbjct: 841 PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK 900
Query: 901 RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM 960
RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM
Sbjct: 901 RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM 960
Query: 961 SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL 1020
SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL
Sbjct: 961 SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL 1020
Query: 1021 VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY 1080
VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY
Sbjct: 1021 VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY 1080
Query: 1081 TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR 1140
TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR
Sbjct: 1081 TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR 1140
Query: 1141 PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH 1200
PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH
Sbjct: 1141 PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH 1200
Query: 1201 LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD 1260
LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD
Sbjct: 1201 LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD 1260
Query: 1261 GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED 1320
GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED
Sbjct: 1261 GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED 1320
Query: 1321 EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT 1380
EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT
Sbjct: 1321 EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT 1380
Query: 1381 EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA 1440
EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA
Sbjct: 1381 EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA 1440
Query: 1441 GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV 1500
GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV
Sbjct: 1441 GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV 1500
Query: 1501 SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV 1560
SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV
Sbjct: 1501 SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV 1560
Query: 1561 IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG 1620
IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG
Sbjct: 1561 IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG 1620
Query: 1621 ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV 1680
ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV
Sbjct: 1621 ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV 1680
Query: 1681 AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE 1740
AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE
Sbjct: 1681 AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE 1740
Query: 1741 TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP 1800
TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP
Sbjct: 1741 TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP 1800
Query: 1801 AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK 1860
AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK
Sbjct: 1801 AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK 1860
Query: 1861 QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE
Sbjct: 1861 QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
Query: 1921 GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL 1980
GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL
Sbjct: 1921 GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL 1980
Query: 1981 IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA 2040
IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA
Sbjct: 1981 IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA 2040
Query: 2041 HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH 2100
HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH
Sbjct: 2041 HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH 2100
Query: 2101 MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG 2160
MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG
Sbjct: 2101 MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG 2160
Query: 2161 QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES 2220
QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES
Sbjct: 2161 QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES 2220
Query: 2221 KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV 2280
KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV
Sbjct: 2221 KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV 2280
Query: 2281 IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF 2340
IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF
Sbjct: 2281 IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF 2340
Query: 2341 VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD 2400
VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD
Sbjct: 2341 VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD 2400
Query: 2401 RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL 2460
RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL
Sbjct: 2401 RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL 2460
Query: 2461 VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH 2520
VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH
Sbjct: 2461 VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH 2520
Query: 2521 VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD 2580
VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD
Sbjct: 2521 VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD 2580
Query: 2581 SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP 2640
SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP
Sbjct: 2581 SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP 2640
Query: 2641 LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM 2700
LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM
Sbjct: 2641 LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM 2700
Query: 2701 PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE 2760
PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE
Sbjct: 2701 PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE 2760
Query: 2761 YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE 2820
YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE
Sbjct: 2761 YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE 2820
Query: 2821 WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE 2880
WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE
Sbjct: 2821 WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE 2880
Query: 2881 NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG 2940
NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG
Sbjct: 2881 NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG 2940
Query: 2941 LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK 3000
LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK
Sbjct: 2941 LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK 3000
Query: 3001 ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD 3060
ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD
Sbjct: 3001 ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD 3060
Query: 3061 APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART 3120
APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART
Sbjct: 3061 APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART 3120
Query: 3121 QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN 3180
QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN
Sbjct: 3121 QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN 3180
Query: 3181 TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC 3240
TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC
Sbjct: 3181 TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC 3240
Query: 3241 PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA 3300
PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA
Sbjct: 3241 PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA 3300
Query: 3301 PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP 3360
PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP
Sbjct: 3301 PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP 3360
Query: 3361 TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR 3420
TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR
Sbjct: 3361 TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR 3420
Query: 3421 AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK 3480
AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK
Sbjct: 3421 AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK 3480
Query: 3481 AGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY 3540
AGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY
Sbjct: 3481 AGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY 3540
Query: 3541 ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS 3600
ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS
Sbjct: 3541 ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS 3600
Query: 3601 AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA 3660
AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA
Sbjct: 3601 AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA 3660
Query: 3661 WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY 3720
WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY
Sbjct: 3661 WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY 3720
Query: 3721 LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ 3780
LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ
Sbjct: 3721 LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ 3780
Query: 3781 MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV 3840
MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV
Sbjct: 3781 MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV 3840
Query: 3841 LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN 3900
LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN
Sbjct: 3841 LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN 3900
Query: 3901 YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV 3960
YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV
Sbjct: 3901 YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV 3960
Query: 3961 FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK 4020
FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK
Sbjct: 3961 FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK 4020
Query: 4021 DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV 4080
DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV
Sbjct: 4021 DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV 4080
Query: 4081 TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF 4140
TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF
Sbjct: 4081 TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF 4140
Query: 4141 NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN 4200
NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN
Sbjct: 4141 NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN 4200
Query: 4201 RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD 4260
RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD
Sbjct: 4201 RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD 4260
Query: 4261 EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL 4320
EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL
Sbjct: 4261 EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL 4320
Query: 4321 RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL 4380
RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL
Sbjct: 4321 RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL 4380
Query: 4381 AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV 4440
AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV
Sbjct: 4381 AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV 4440
Query: 4441 TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE 4500
TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE
Sbjct: 4441 TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE 4500
Query: 4501 PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF 4560
PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF
Sbjct: 4501 PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF 4560
Query: 4561 YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA 4620
YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA
Sbjct: 4561 YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA 4620
Query: 4621 EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR 4680
EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR
Sbjct: 4621 EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR 4680
Query: 4681 KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE 4740
KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE
Sbjct: 4681 KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE 4740
Query: 4741 LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS 4800
LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS
Sbjct: 4741 LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS 4800
Query: 4801 LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF 4860
LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF
Sbjct: 4801 LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF 4860
Query: 4861 RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT 4920
RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT
Sbjct: 4861 RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT 4920
Query: 4921 FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT 4980
FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT
Sbjct: 4921 FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT 4980
Query: 4981 LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5038
LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS
Sbjct: 4981 LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5038
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 1.017e+04 bits (26385), Expect = 0.0
Identities = 5033/5038 (99%), Positives = 5033/5038 (99%), Gaps = 5/5038 (0%)
Query: 1 MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD 60
MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD
Sbjct: 1 MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPD 60
Query: 61 LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120
LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL
Sbjct: 61 LAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120
Query: 121 TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180
TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH
Sbjct: 121 TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180
Query: 181 LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ 240
LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ
Sbjct: 181 LSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHVLRLFHGHMDECLTISPADSDDQ 240
Query: 241 RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV 300
RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV
Sbjct: 241 RRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQGLVV 300
Query: 301 VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA 360
VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA
Sbjct: 301 VDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA 360
Query: 361 PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420
PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF
Sbjct: 361 PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420
Query: 421 SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480
SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE
Sbjct: 421 SGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480
Query: 481 GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS 540
GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS
Sbjct: 481 GMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFS 540
Query: 541 TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD 600
TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD
Sbjct: 541 TNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD 600
Query: 601 VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK 660
VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK
Sbjct: 601 VLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSK 660
Query: 661 WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL 720
WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL
Sbjct: 661 WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHL 720
Query: 721 WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV 780
WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV
Sbjct: 721 WTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVV 780
Query: 781 SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG 840
SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG
Sbjct: 781 SFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVG 840
Query: 841 PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK 900
PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK
Sbjct: 841 PSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNK 900
Query: 901 RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM 960
RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM
Sbjct: 901 RLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMM 960
Query: 961 SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL 1020
SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL
Sbjct: 961 SNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRL 1020
Query: 1021 VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY 1080
VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY
Sbjct: 1021 VPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSY 1080
Query: 1081 TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR 1140
TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR
Sbjct: 1081 TVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGR 1140
Query: 1141 PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH 1200
PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH
Sbjct: 1141 PWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGH 1200
Query: 1201 LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD 1260
LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD
Sbjct: 1201 LNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVD 1260
Query: 1261 GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED 1320
GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED
Sbjct: 1261 GTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED 1320
Query: 1321 EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT 1380
EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT
Sbjct: 1321 EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGGEAQPARAENEKDATT 1380
Query: 1381 EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA 1440
EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA
Sbjct: 1381 EKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVRVFA 1440
Query: 1441 GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV 1500
GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV
Sbjct: 1441 GQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVWGGDFV 1500
Query: 1501 SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV 1560
SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV
Sbjct: 1501 SPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNV 1560
Query: 1561 IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG 1620
IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG
Sbjct: 1561 IQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHFLQVETRRAG 1620
Query: 1621 ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV 1680
ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV
Sbjct: 1621 ERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLYRAVCALGNNRV 1680
Query: 1681 AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE 1740
AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE
Sbjct: 1681 AHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPE 1740
Query: 1741 TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP 1800
TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP
Sbjct: 1741 TRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGAAEAPARLSP 1800
Query: 1801 AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK 1860
AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK
Sbjct: 1801 AIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVK 1860
Query: 1861 QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE
Sbjct: 1861 QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
Query: 1921 GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL 1980
GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL
Sbjct: 1921 GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL 1980
Query: 1981 IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA 2040
IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA
Sbjct: 1981 IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA 2040
Query: 2041 HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH 2100
HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH
Sbjct: 2041 HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSH 2100
Query: 2101 MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG 2160
MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG
Sbjct: 2101 MVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLG 2160
Query: 2161 QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES 2220
QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES
Sbjct: 2161 QIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGES 2220
Query: 2221 KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV 2280
KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV
Sbjct: 2221 KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV 2280
Query: 2281 IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF 2340
IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF
Sbjct: 2281 IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAKGYPDIGWNPCGGERYLDFLRFAVF 2340
Query: 2341 VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD 2400
VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD
Sbjct: 2341 VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRD 2400
Query: 2401 RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL 2460
RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL
Sbjct: 2401 RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL 2460
Query: 2461 VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH 2520
VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH
Sbjct: 2461 VPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH 2520
Query: 2521 VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD 2580
VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD
Sbjct: 2521 VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD 2580
Query: 2581 SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP 2640
SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP
Sbjct: 2581 SMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMP 2640
Query: 2641 LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM 2700
LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM
Sbjct: 2641 LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAM 2700
Query: 2701 PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE 2760
PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE
Sbjct: 2701 PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE 2760
Query: 2761 YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE 2820
YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE
Sbjct: 2761 YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE 2820
Query: 2821 WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE 2880
WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE
Sbjct: 2821 WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAE 2880
Query: 2881 NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG 2940
NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG
Sbjct: 2881 NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG 2940
Query: 2941 LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK 3000
LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK
Sbjct: 2941 LKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK 3000
Query: 3001 ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD 3060
ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD
Sbjct: 3001 ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD 3060
Query: 3061 APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART 3120
APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART
Sbjct: 3061 APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART 3120
Query: 3121 QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN 3180
QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN
Sbjct: 3121 QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN 3180
Query: 3181 TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC 3240
TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC
Sbjct: 3181 TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNSVEEMC 3240
Query: 3241 PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA 3300
PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA
Sbjct: 3241 PDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPSALPAGA 3300
Query: 3301 PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP 3360
PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP
Sbjct: 3301 PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLQSHFIP 3360
Query: 3361 TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR 3420
TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR
Sbjct: 3361 TIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR 3420
Query: 3421 AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK 3480
AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK
Sbjct: 3421 AQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK 3480
Query: 3481 AGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY 3540
SGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY
Sbjct: 3481 -----SGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQDLITLAKTRY 3535
Query: 3541 ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS 3600
ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS
Sbjct: 3536 ALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS 3595
Query: 3601 AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA 3660
AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA
Sbjct: 3596 AVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAA 3655
Query: 3661 WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY 3720
WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY
Sbjct: 3656 WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY 3715
Query: 3721 LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ 3780
LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ
Sbjct: 3716 LYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQ 3775
Query: 3781 MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV 3840
MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV
Sbjct: 3776 MISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSV 3835
Query: 3841 LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN 3900
LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN
Sbjct: 3836 LDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQN 3895
Query: 3901 YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV 3960
YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV
Sbjct: 3896 YLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQV 3955
Query: 3961 FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK 4020
FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK
Sbjct: 3956 FNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQK 4015
Query: 4021 DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV 4080
DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV
Sbjct: 4016 DMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYV 4075
Query: 4081 TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF 4140
TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF
Sbjct: 4076 TDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGF 4135
Query: 4141 NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN 4200
NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN
Sbjct: 4136 NVAVLLTNLSEHVPHDPRLHNFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISETN 4195
Query: 4201 RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD 4260
RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD
Sbjct: 4196 RAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETD 4255
Query: 4261 EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL 4320
EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL
Sbjct: 4256 EDEGAGAAEAGAEGAEEGAAGLEGTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRL 4315
Query: 4321 RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL 4380
RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL
Sbjct: 4316 RRLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELL 4375
Query: 4381 AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV 4440
AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV
Sbjct: 4376 AGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAV 4435
Query: 4441 TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE 4500
TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE
Sbjct: 4436 TDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELE 4495
Query: 4501 PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF 4560
PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF
Sbjct: 4496 PEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNF 4555
Query: 4561 YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA 4620
YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA
Sbjct: 4556 YTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEA 4615
Query: 4621 EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR 4680
EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR
Sbjct: 4616 EGDEDENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELAR 4675
Query: 4681 KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE 4740
KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE
Sbjct: 4676 KLEFDGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAE 4735
Query: 4741 LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS 4800
LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS
Sbjct: 4736 LLGMDLATLEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMS 4795
Query: 4801 LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF 4860
LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF
Sbjct: 4796 LLGHYNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFF 4855
Query: 4861 RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT 4920
RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT
Sbjct: 4856 RKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDIT 4915
Query: 4921 FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT 4980
FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT
Sbjct: 4916 FFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT 4975
Query: 4981 LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5038
LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS
Sbjct: 4976 LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5033
>gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]
Length = 4967
Score = 6623 bits (17183), Expect = 0.0
Identities = 3307/5078 (65%), Positives = 4025/5078 (79%), Gaps = 160/5078 (3%)
Query: 5 EGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAIC 64
EGEDE+QFLRTDDEVVLQC+AT+ KEQ KLCLAAEGFGNRLCFLE TSN++NVPPDL+IC
Sbjct: 6 EGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSIC 65
Query: 65 CFVLEQSLSVRALQEMLANTVEAG------------VESSQGGGHRTLLYGHAILLRHAH 112
FVLEQSLSVRALQEMLANTVE ++++QGGGHRTLLYGHAILLRH++
Sbjct: 66 TFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSY 125
Query: 113 SRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVS 172
S MYL CL+TSRS TDKLAFDVGLQED TGEACWWT+HPASKQRSEGEKVRVGDD+ILVS
Sbjct: 126 SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS 185
Query: 173 VSSERYLHLSTASGELQVDASFMQTLWNMNPICSRCE--EGFVTGGHVLRLFHGHMDECL 230
VSSERYLHLS +G L VDA+F QTLW++ PI S E +G++ GG VLRL HGHMDECL
Sbjct: 186 VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECL 245
Query: 231 TISPAD-SDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQY 289
T+ + ++QRR V+YEGGAV HARSLWRLE LR++WSGSH+RWGQP R+RHVTTG+Y
Sbjct: 246 TVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKY 305
Query: 290 LALTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQH 349
L+L ED+ L+++D KA K+T+F FR SKEKLDV +++V+GMG EIKYG+S+C++QH
Sbjct: 306 LSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQH 365
Query: 350 VASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGL 409
V +GLWLTY + D K++R+G +++KA++H EGHMDD +SL+R Q EES+ AR+I ST L
Sbjct: 366 VDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFL 425
Query: 410 YNQFIKSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRS 469
+N+FI+ LD+ S K + S LPIE V LSLQDLI YF PP E L+HE+KQ++LR+
Sbjct: 426 FNRFIRGLDALSKKAKAST----VDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRA 481
Query: 470 LRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLI 529
L+NRQ+LFQEEGM+++VL CIDRL+VY++AAHFA+ AG EA ESWK I+N LYELLA+LI
Sbjct: 482 LKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALI 541
Query: 530 RGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLL 589
RGNR NCA FS +LDWL+S+L+RLEASSGILEVL+CVL+ESPE LNII+E HIKSIISLL
Sbjct: 542 RGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLL 601
Query: 590 DKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFV 649
DKHGRNHKVLDVLCSLCVC+GVAVRSNQ LI +NLLPGR+LLLQT L+N+V+S+RPNIF+
Sbjct: 602 DKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFL 661
Query: 650 GRAEGTTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDD 709
G +EG+ QY KWY+E+MVD PF+TA+ATHLRVGWA TEGY+PYPG GE WGGNGVGDD
Sbjct: 662 GVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDD 721
Query: 710 LYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFES 769
L+SYGFDGLHLW+G +AR V+SP QHLL +DVISCCLDLS PSISFRING PVQG+FE+
Sbjct: 722 LFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFEN 781
Query: 770 FNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYR 829
FN+DGLFFPVVSFSAG+KVRFLLGGRHGEFKFLPPPGYAPC+EAVLP+E+L +E +EY+
Sbjct: 782 FNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYK 841
Query: 830 REGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQG 889
+E L+GP+ L+ F P PVDT QIVLPPHLERIREKLAENIHELW + +IE G
Sbjct: 842 QERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELG 901
Query: 890 WTYGPVRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNL 949
W YGPVRDDNKR HPCLV+F LPE ERNYNLQMS ETLKTLLALGCHVG++DE AED +
Sbjct: 902 WQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKV 961
Query: 950 KKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAV 1009
KK KLPK Y +++GYKPAP+DLS ++LTP+Q +VD+LAEN HNVWARDR+ QGW+Y
Sbjct: 962 KKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQ 1021
Query: 1010 QDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVEN--QSR 1067
QD+ RRNPRLVPY LLD+ TK+SN+DSL +AVRTLLGYGYN+E PDQ+ +
Sbjct: 1022 QDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGT 1081
Query: 1068 CDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHR 1127
+R RIFRAEK+Y V++GRWYFEFE VT G+MRVGW+RP +PD ELG+DE A+ F+G +
Sbjct: 1082 GERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFK 1141
Query: 1128 GQRWHLGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGF 1187
QRWH G+E +GR WQ GDVVGCM+D+ E+T++FTLNGE+L+ DSGSE AF++ ++GDGF
Sbjct: 1142 AQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGF 1201
Query: 1188 LPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPV 1247
+PVCSLG QVG +N G+DVS+L++F ICGLQEG+EPFA+N R +T W SK LPQF V
Sbjct: 1202 IPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQV 1261
Query: 1248 PLEHPHYEVSRVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHF-RCTAGA 1306
P H H EV+R+DGT+D+ PCL++T +++GSQNS +++F RLS+P++ + F + AG
Sbjct: 1262 PSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGG 1321
Query: 1307 TPLAPPGLQPPAEDEARAAEPDPDYENLRRSAGGW---SEAENGKEGTAKEGAPGGTPQA 1363
P A GL P D + D D+E L ++A G + KE T E
Sbjct: 1322 LPGA--GLFGPKND-LEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPE--------- 1369
Query: 1364 GGEAQPARAENEKDATTEK--NKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRD 1421
N KD EK K+ FL + K T A RL DV+ AD+RD
Sbjct: 1370 --------FNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSA-----RLTEDVL-ADDRD 1415
Query: 1422 DPEIILNTTTYYYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGN 1481
D + ++ T+TYYYSVR+F GQEP+ VW GW+T D+HQ+D FDL +VR VTVT+GDE+G
Sbjct: 1416 DYDFLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGK 1475
Query: 1482 VHSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQV 1541
VH S+K SNCYMV G+ +SPG QGR ++ L IGC+VD A+GL+TF ANGKE +T++QV
Sbjct: 1476 VHESIKRSNCYMVCAGESMSPG-QGR-NNNGLEIGCVVDAASGLLTFIANGKELSTYYQV 1533
Query: 1542 EPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMP 1601
EP+TKLFPAVF T NV QFELG+ KN+MPLSA +F+SE KNP PQCPPRL +Q L
Sbjct: 1534 EPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSH 1593
Query: 1602 VSWSRMPNHFLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRF 1661
V WSRMPN FL+V+ R ER GW VQC +PL M+LHIPEENR +DILEL+E+ +L +F
Sbjct: 1594 VLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKF 1653
Query: 1662 HSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLES 1721
H HTLRLY AVCALGN+RVAHALCSHVD+ QLL+A+E+ ++PG LRAGYYDLLI IHL S
Sbjct: 1654 HYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSS 1713
Query: 1722 ACRSRRSMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPC 1781
+R M +EYIVP+T ET++ITLFP + + +HGLPG+G++TSLRP FS P
Sbjct: 1714 YATARLMMNNEYIVPMTEETKSITLFP------DENKKHGLPGIGLSTSLRPRMQFSSPS 1767
Query: 1782 FVAALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPV 1841
FV+ + + SP PL+ L+ K ++ML EAV++G HARDPVGG+ EF FVP+
Sbjct: 1768 FVS------ISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPL 1821
Query: 1842 LKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQ 1901
+KL TLL+MGIF +ED+K IL++IEP VF E E EE D EKE ++
Sbjct: 1822 IKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPE------EESDTLEKELSVDDAKL 1875
Query: 1902 EKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAF 1961
+ EEEA G++ +EGLLQMKLPE VKLQMC LL+Y CD +++HR+E++ AF
Sbjct: 1876 QGAG----EEEAKGGKRP---KEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAF 1928
Query: 1962 AERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDC 2021
++ +V KLQ NQR RY +++A +M+AA TAR+T+EFRSPPQEQINMLL FKD D+ +C
Sbjct: 1929 SDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKD--DKSEC 1986
Query: 2022 PLPEEIRQDLLDFHQDLLAHCGIQLDGEEE-EPEEETTLGSRLMSLLEKVRLVKKKE-EK 2079
P PEEIR LLDFH+DL+ HCGI+LD + + + T+ RL+SL+EKV +KKK+ EK
Sbjct: 1987 PCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEK 2046
Query: 2080 PEEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALP 2139
P E ++ K +LQ+L+S +VRWAQE ++ PELVRAMF LLHRQYDG+G L+RALP
Sbjct: 2047 PVE---SDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALP 2103
Query: 2140 RAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMR 2199
+ YTI+ SVEDT++LL LGQIRSLL V+MG +EE LMI+ +G+IMNNKVFYQHPNLMR
Sbjct: 2104 KTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMR 2163
Query: 2200 ALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLE 2259
ALGMHETVMEVMVNVLGGGESKEI FPKMV +CCRFLCYFCRISRQNQ++MFDHLSYLLE
Sbjct: 2164 ALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLE 2223
Query: 2260 NSGIGL---GMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAK 2316
NS +GL M+GSTPLDVAAASV+DNNELALAL+E DLEKVV YLAGCGLQSC MLV+K
Sbjct: 2224 NSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSK 2283
Query: 2317 GYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGL 2376
GYPDIGWNP GERYLDFLRFAVF NGESVEENANVVVRLLIR+PECFGPALRGEGG+GL
Sbjct: 2284 GYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGL 2343
Query: 2377 LAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRC 2436
LAA+EEAI+I+EDP+RDGP + E E++ +H+G+AIM+FY+ALIDLLGRC
Sbjct: 2344 LAAMEEAIKIAEDPSRDGPSPNSGSSKT-LDTEEEEDDTIHMGNAIMTFYSALIDLLGRC 2402
Query: 2437 APEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVP 2496
APEMHLI AGKGEA+RIR+ILRSL+PL DLVG+IS+ Q+PT+ KDG +V+P MSA F P
Sbjct: 2403 APEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCP 2462
Query: 2497 DHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCL 2556
DHKA+MVLFLDRVYGIE QDFLLH+L+VGFLPD+RAAASLDTA S T+MALALNRYLC
Sbjct: 2463 DHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCT 2522
Query: 2557 AVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRP 2616
AVLPL+T+CAPLFAGTEH A ++DS+LHTVYRLS+G SLTKAQRD IE CL+S+C +RP
Sbjct: 2523 AVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRP 2582
Query: 2617 SMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTR 2676
SM+QHLLRRLVFDVP+LNE AKMPLKLLTNHYERCWKYYCLP GW NFG SEEELHL+R
Sbjct: 2583 SMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSR 2642
Query: 2677 KLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFD 2736
KLFWGIFD+L+ KKY+ EL+++A+PCL A+AGALPPDY++++Y S EK++++D+EGNF+
Sbjct: 2643 KLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFN 2702
Query: 2737 PRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKT 2796
P+PV+T N+ IPEKL+ FINK+AE++H+KW+ DK+ N W YGE + K P+++PYK
Sbjct: 2703 PQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKL 2762
Query: 2797 FSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQ-TYDPREGY 2855
SEK+KEIYRWPIKESLK M+AW W IE+ REG + +TR+ISQ++Q + D GY
Sbjct: 2763 LSEKEKEIYRWPIKESLKTMLAWGWRIERTREG-DSMALYNRTRRISQTSQVSVDAAHGY 2821
Query: 2856 NPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKE 2915
+P+ D+S VTLSR+L AMAE +AENYHN W +KKK ELE+KGGG HPLLVPYDTLTAKE
Sbjct: 2822 SPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKE 2881
Query: 2916 KARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIA 2975
KA+DREKAQ++LKFLQ+NGYAV+RG KD+ELD+ SIEKRFA+ FLQQL+R++D + ++I
Sbjct: 2882 KAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYIL 2941
Query: 2976 HLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKE 3035
+ S G+ E P+EQEIKFFAK++LPLI+QYF NH LYFLS ++ L SGGHASNKE
Sbjct: 2942 EFDG-GSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE 3000
Query: 3036 KEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSF 3095
KEM+TSLFCKL LVRHR+SLFG DA ++VNCLHIL ++LDARTVMK+G E VK+ LR+F
Sbjct: 3001 KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF 3060
Query: 3096 FESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDD 3155
++A+ED+EK +ENL+ G+ + R Q KGV Q + YTTVALLP+L++LF+HI QHQFG+D
Sbjct: 3061 LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED 3120
Query: 3156 VILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNA 3215
+IL+DVQVSCYR L S+Y+LGT+K+ YVE+ R ALGECLA A A PVAFLE L+++N
Sbjct: 3121 LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI 3180
Query: 3216 CSVYTTKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLP 3275
S+Y TKS RERA L LP +VE++CP+IP LE+LM +I LAESG RYT+MPHV+E+ LP
Sbjct: 3181 YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP 3240
Query: 3276 MLCSYLPRWWERGPEAPPSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWM 3335
MLCSY+ RWWE GPE P A CTA+ S+H+N+LLGNIL+II NNLGIDE +WM
Sbjct: 3241 MLCSYMSRWWEHGPENNPER----AEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWM 3296
Query: 3336 KRLAVFAQPIVSRARPELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVR 3395
KRLAVF+QPI+++ +P+LL++HF+P + +L+K+A VVSEE+ L+ EA+ + E ELL+
Sbjct: 3297 KRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLIL 3356
Query: 3396 DEFSVLCRDLYALYPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREE 3455
DEF+ L RDLYA YPLLIR+VD NRA+WL EPNP AEELFRMV E+FIYWSKSHNFKREE
Sbjct: 3357 DEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREE 3416
Query: 3456 QNFVVQNEINNMSFLTADNKSKMAKAGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLK 3515
QNFVVQNEINNMSFL D KSKM+KA SDQER K KR+GDRYS+QTSLIVA LK
Sbjct: 3417 QNFVVQNEINNMSFLITDTKSKMSKA-----AVSDQERKKMKRKGDRYSMQTSLIVAALK 3471
Query: 3516 KMLPIGLNMCAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMAL 3575
++LPIGLN+CAP DQ+LI LAK R++LKDT++EVR+ + +N+HLQGK+E P++RWQMAL
Sbjct: 3472 RLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLE-DPAIRWQMAL 3530
Query: 3576 YRGVPGREEDADDPEKIVRRVQEVSAVLYYLDQ------------TEHPYKSKKAVWHKL 3623
Y+ +P R +D DPEK V RV +++ VL++L+Q EHP +SKKAVWHKL
Sbjct: 3531 YKDLPNRTDDTSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKL 3590
Query: 3624 LSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQ 3683
LSKQR+RAVVACFRM PLYNLP HRA N+FL+ Y+ +WI TE+H FED++I+DL+K G +
Sbjct: 3591 LSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAE 3650
Query: 3684 EEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGE 3743
EE+E K+ DPLHQL+L FSRTALTEK KL+ED+LYMAYADIMAKSCH E E+ +
Sbjct: 3651 PPEEDE-GTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDE---EDDD 3706
Query: 3744 AEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISI 3803
EEEV+ SFEEK+MEKQ+LLYQQARLH RGAAEMVLQ ISA KGETG MV++TLKLGI+I
Sbjct: 3707 GEEEVK-SFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAI 3765
Query: 3804 LNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGT 3863
LNGGN+ VQQKMLDYLK+KK+VGFFQS+ LMQ+CSVLDLNAFERQNKAEGLGMV E+G
Sbjct: 3766 LNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEG- 3824
Query: 3864 VINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLL 3923
+GEKV+ DDEFT DLFRFLQLLCEGHN+DFQNYLRTQTGN TT+NIII TVDYLL
Sbjct: 3825 -----SGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLL 3879
Query: 3924 RLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSR 3983
R+QESISDFYWYYSGKDVI+EQG+RNFSKA+ VAKQVFN+LTEYIQGPCTGNQQSLAHSR
Sbjct: 3880 RVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSR 3939
Query: 3984 LWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQM 4043
LWDAVVGFLHVFAHM MKL+QDSSQIELLKEL+DLQKDMVVMLLS+LEGNVVNG I +QM
Sbjct: 3940 LWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQM 3999
Query: 4044 VDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFS 4103
VDMLVESS+NVEMILKFFDMFLKLKD+ S+ F++Y D +G+ISK+DF KAM+S K ++
Sbjct: 4000 VDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYT 4059
Query: 4104 GPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFL 4163
E +FLLSC+E DENE ++ EEF RF EPA+DIGFNVAVLLTNLSEH+P+D RL FL
Sbjct: 4060 QSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFL 4119
Query: 4164 ELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNE 4223
ELAES+L YF+P+LGRIEIMG+++RIER+YFEISE++R QWE PQVKESKRQFIFDVVNE
Sbjct: 4120 ELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNE 4179
Query: 4224 GGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETDEDEGAGAAEAGAEGAEEGAAGLE 4283
GGE EKMELFV+FCEDTIFEMQ+AAQISE + + A E+ E EE +
Sbjct: 4180 GGEKEKMELFVNFCEDTIFEMQLAAQISESD-----LNERSANKEESEKERPEEQGPRMA 4234
Query: 4284 GTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTRA 4343
+ A + +R LS +SL++++++++++T ++ TA + W+
Sbjct: 4235 FFSILTVRSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTL 4294
Query: 4344 GAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDA 4403
A G ++ L GG LVEGAKK+ V ELLA MPDPT DEV G+ G
Sbjct: 4295 LHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKPL 4354
Query: 4404 DGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPA 4463
+ SE D E +E + + + G +GG ++ + D
Sbjct: 4355 EAALPSEDLTDLKE-LTEESDLLSD-----IFGLDLKREGGQYKLIPHNPNAGLSDLMSN 4408
Query: 4464 EPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEE-VPEPTPEPP 4522
P PE ++ K +EE E E + E + EPEKA+ E+GEKEE E +
Sbjct: 4409 PVPMPE----VQEKFQEQKAKEE---EKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQK 4461
Query: 4523 KKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYK 4582
+Q + E FW ++ + K LNY +RNFY +R LALF+AFAINFILLFYK
Sbjct: 4462 LRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYK 4521
Query: 4583 VSDSPPGE-DDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYFLEESTGYME 4641
VS S E ++ ++ + + S SS + A V+Y LEES+GYME
Sbjct: 4522 VSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIA------------VHYVLEESSGYME 4569
Query: 4642 PALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQ 4701
P LR L++LHT+++F CIIGY CLKVPLVIFKREKE+ARKLEFDGLYITEQP +DD+KGQ
Sbjct: 4570 PTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQ 4629
Query: 4702 WDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEIT-AHNERKPN 4760
WDRLV+NT SFP+NYWDKFVKRKV+DK+G+ YGR+RI+ELLGMD A L+ + A ++KP
Sbjct: 4630 WDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPK 4689
Query: 4761 PPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMG 4820
L L SIDVKYQ+WK GV+FTDNSFLYL WYM MS+LGHYNNFFFAAHLLDIAMG
Sbjct: 4690 KDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMG 4749
Query: 4821 VKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDM 4880
KTLRTILSSVTHNGKQLV+TVGLLAVVVYLYTVVAFNFFRKFYNKSED D PDMKCDDM
Sbjct: 4750 FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDM 4809
Query: 4881 MTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDA 4940
+TCY+FHMYVGVRAGGGIGDEIEDPAGDEYE+YR++FDITFFFFVIVILLAIIQGLIIDA
Sbjct: 4810 LTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDA 4869
Query: 4941 FGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKD 5000
FGELRDQQEQVKEDMETKCFICGIG+DYFDT PHGFETHTL+EHNLANY+FFLMYLINKD
Sbjct: 4870 FGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKD 4929
Query: 5001 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5038
ETEHTGQESYVWKMYQERCW+FFPAGDCFRKQYEDQL+
Sbjct: 4930 ETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN 4967
>gi|126032338 ryanodine receptor 3 [Homo sapiens]
Length = 4870
Score = 4771 bits (12374), Expect = 0.0
Identities = 2379/3637 (65%), Positives = 2894/3637 (79%), Gaps = 109/3637 (2%)
Query: 1424 EIILNTTTY-YYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNV 1482
EI+ +TTT YY++R+FAGQ+PSCVW GWVTPDYH + FDL+K VTVT+GDE+G V
Sbjct: 1319 EILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRV 1378
Query: 1483 HSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVE 1542
H S+K SNCYMVWGGD V+ Q+ S+ DL IGCLVDLA G+++F+ANGKE T +QVE
Sbjct: 1379 HESVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVE 1438
Query: 1543 PNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPV 1602
PNTK+FPAVF+ PT ++ QFELGK KN MPLSAA+F+SE KNP PQCPPRL++Q + PV
Sbjct: 1439 PNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSEEKNPVPQCPPRLDVQTIQPV 1498
Query: 1603 SWSRMPNHFLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFH 1662
WSRMPN FL+VET R ER GW VQC EPL MMALHIPEENRC+DILEL E+ DL RFH
Sbjct: 1499 LWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFH 1558
Query: 1663 SHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESA 1722
HTLRLY AVCALGN+RVA+ALCSHVD +QL +A+++ +LPG LR+G+YDLLISIHL SA
Sbjct: 1559 YHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLASA 1618
Query: 1723 CRSRRSMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCF 1782
+ M +EYI+P+T TR I LFP + RHGLPGVG+ T L+P FS PCF
Sbjct: 1619 KERKLMMKNEYIIPITSTTRNIRLFP------DESKRHGLPGVGLRTCLKPGFRFSTPCF 1672
Query: 1783 VAALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVL 1842
V E + SP IPLE+LR KAL ML EAV+ G H RDPVGGSVEFQFVPVL
Sbjct: 1673 VVT------GEDHQKQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVL 1726
Query: 1843 KLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQE 1902
KL+ TLLVMG+F D+DV+QIL +I+P VF E G EE E
Sbjct: 1727 KLIGTLLVMGVFDDDDVRQILLLIDPSVF-------GEHSAGTEE------------GAE 1767
Query: 1903 KEDEEKEEEEAAEGEKEEGLE---EGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLA 1959
KE+ + EE+A E ++ G E +GLLQ +LPESVKLQMC LL Y CD ELQHRVE++
Sbjct: 1768 KEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIV 1827
Query: 1960 AFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEE 2019
AF + YV KLQANQ+ RY L++A +M+AA TAR+T+EFRSPPQEQINMLL F+ G E
Sbjct: 1828 AFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTKEFRSPPQEQINMLLNFQLG---E 1884
Query: 2020 DCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEK 2079
+CP PEEIR++L DFH+DLL HCG+ L+ EEEE EE+T+ +L +L+ K+ K K
Sbjct: 1885 NCPCPEEIREELYDFHEDLLLHCGVPLE-EEEEEEEDTSWTGKLCALVYKI----KGPPK 1939
Query: 2080 PEEERSAEESK--PRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRA 2137
PE+E+ EE + P +L+EL+S ++ WAQED +Q ELVR MF+LL RQYD +GELL+A
Sbjct: 1940 PEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDSELVRMMFNLLRRQYDSIGELLQA 1999
Query: 2138 LPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNL 2197
L + YTIS +SV DT++LL LGQIRSLL V+MG +EE LMI +G+IMNNKVFYQHPNL
Sbjct: 2000 LRKTYTISHTSVSDTINLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNL 2059
Query: 2198 MRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYL 2257
MR LGMHETVMEVMVNVLG E +I FPKMV SCCRFLCYFCRISRQNQ++MF+HLSYL
Sbjct: 2060 MRVLGMHETVMEVMVNVLGT-EKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYL 2118
Query: 2258 LENSGIGLG---MQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLV 2314
LENS +GL M+GSTPLDVAA+SV+DNNELAL+L+E DLEKVV+YLAGCGLQSCPML+
Sbjct: 2119 LENSSVGLASPSMRGSTPLDVAASSVMDNNELALSLEEPDLEKVVTYLAGCGLQSCPMLL 2178
Query: 2315 AKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGS 2374
AKGYPD+GWNP GERYL FLRFAVFVN ESVEENA+VVV+LLIR+PECFGPALRGEGG+
Sbjct: 2179 AKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGN 2238
Query: 2375 GLLAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLG 2434
GLLAA++ AI+ISE+PA D P + +R G++ EE VH+G+AIMSFY+ALIDLLG
Sbjct: 2239 GLLAAMQGAIKISENPALDLPS-QGYKREVSTGDDEEEEEIVHMGNAIMSFYSALIDLLG 2297
Query: 2435 RCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASF 2494
RCAPEMHLIQ GKGEA+RIR+ILRSLVP EDLVGIIS+PL++P+L KDG++ +P M+A+F
Sbjct: 2298 RCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANF 2357
Query: 2495 VPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYL 2554
PDHKA MVLFLDRVYGI++Q FLLH+L+VGFLPD+RA+ASLDT + STTE ALALNRY+
Sbjct: 2358 CPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYI 2417
Query: 2555 CLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYI 2614
C AVLPL+T+CAPLFAGTEH ++DS L T+YRLS+GRSLTKAQRD IE+CL+++C ++
Sbjct: 2418 CSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHL 2477
Query: 2615 RPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHL 2674
RPSMLQ LLRRLVFDVP LNE+ KMPLKLLTNHYE+CWKYYCLP+GW ++G+ EEELHL
Sbjct: 2478 RPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHL 2537
Query: 2675 TRKLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGN 2734
T KLFWGIFDSL+HKKYDP+L+RMA+PCL AIAGALPPDY+D ++ EK+ +VDA+GN
Sbjct: 2538 TEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQISVDADGN 2597
Query: 2735 FDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPY 2794
FDP+P+ T+N +PEKL+ + K+AE++H+KWA DK Q+ W YG ++DE +KTHP++RP+
Sbjct: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657
Query: 2795 KTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEE--EKTEKKKTRKISQSAQTYDPR 2852
KT +EK+KEIYRWP +ESLK M+A WT+E+ +EGE ++ E +K R +SQ+ Q
Sbjct: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQANQG---- 2713
Query: 2853 EGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLT 2912
Y+P P DLS V LSRELQ M E +AENYHN W +KKK ELE+KGGG+HPLLVPYDTLT
Sbjct: 2714 NSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLT 2773
Query: 2913 AKEKARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQE 2972
AKEK +DREKAQ+L KFLQ+NG V+RG+KDMELD+SS+EKRFA+ FL+++L+++D +QE
Sbjct: 2774 AKEKFKDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQE 2833
Query: 2973 FIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHAS 3032
FIAHLEA+VSSG+ EKSP +QEIKFFAK+LLPL++QYFT+HCLYFLS+P K L S G+AS
Sbjct: 2834 FIAHLEAIVSSGKTEKSPRDQEIKFFAKVLLPLVDQYFTSHCLYFLSSPLKPLSSSGYAS 2893
Query: 3033 NKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGL 3092
+KEKEM+ LFCKLAALVRHR+SLFG+D+ +V+CLHILA++LD RTVMKSG E+VKAGL
Sbjct: 2894 HKEKEMVAGLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGL 2953
Query: 3093 RSFFESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQF 3152
R+FFE+A+ED+EK ENL+LGK + +RTQ+KGV QN+ YTTVALLP+LT++F+H+ QHQF
Sbjct: 2954 RAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVTQHQF 3013
Query: 3153 GDDVILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNE 3212
G D++L DVQ+SCY LCS+YSLGT KN YVE+ RPALGECLA LAAA+PVAFLEP LN
Sbjct: 3014 GMDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNR 3073
Query: 3213 YNACSVYTTKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEI 3272
YN SV+ TK+PRER+ILG+P++VE+MCPDIP LE LM +I LAESGARYTEMPHVIE+
Sbjct: 3074 YNPLSVFNTKTPRERSILGMPDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEV 3133
Query: 3273 TLPMLCSYLPRWWERGPEAPPSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEA 3332
LPMLC+YL WWERGPE LP P CT VTS+HL+ +LGNIL+II NNLGIDEA
Sbjct: 3134 ILPMLCNYLSYWWERGPEN----LPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEA 3189
Query: 3333 SWMKRLAVFAQPIVSRARPELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGEL 3392
SWMKR+AV+AQPI+S+ARP+LL+SHFIPT+ +L+K+A K V EEEQL+ + K + QE EL
Sbjct: 3190 SWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLKADGKGDTQEAEL 3249
Query: 3393 LVRDEFSVLCRDLYALYPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFK 3452
L+ DEF+VLCRDLYA YP+LIRYVDNNR+ WL P+ +++LFRMV E+FI W KSHNFK
Sbjct: 3250 LILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFK 3309
Query: 3453 REEQNFVVQNEINNMSFLTADNKSKMAKAGDIQSGGSDQERTKKKRRGDRYSVQTSLIVA 3512
REEQNFV+QNEINN++FLT D+KSKM+KA ++SGG DQER K KRRGD YS+QTSLIVA
Sbjct: 3310 REEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVA 3369
Query: 3513 TLKKMLPIGLNMCAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQ 3572
LKKMLPIGLNMC P DQ+LI+LAK+RY+ +DTDEEVRE L NNLHLQ K + P+++WQ
Sbjct: 3370 ALKKMLPIGLNMCTPGDQELISLAKSRYSHRDTDEEVREHLRNNLHLQEKSD-DPAVKWQ 3428
Query: 3573 MALYRGVPGREEDADDPEKIVRRVQEVSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAV 3632
+ LY+ V + E+ +PEK V RVQ +SA +++L+Q E P +SKKAVWHKLLSKQR+RAV
Sbjct: 3429 LNLYKDVL-KSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAV 3487
Query: 3633 VACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEE 3692
VACFRM PLYNLP HR+ N+FL Y+ WI TE++SFE++++ DL+K+ + EEEEEE E
Sbjct: 3488 VACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEETE 3547
Query: 3693 KKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEEVEVSF 3752
K+PDPLHQ++L+FSR ALTE+SKL++D LY +Y+ +MAKSC + GE+ E +E+ E +F
Sbjct: 3548 KQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSC---QSGEDEEEDEDKEKTF 3604
Query: 3753 EEKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQ 3812
EEK+MEKQ+ LYQQARLH RGAAEMVLQMISA KGE MV TLKLGI+ILNGGNA VQ
Sbjct: 3605 EEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQ 3664
Query: 3813 QKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEK 3872
QKMLDYLK+KK+ GFFQS+ LMQ+CSVLDLNAFERQNKAEGLGMV E+GT+I R+ GEK
Sbjct: 3665 QKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEK 3724
Query: 3873 VMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDF 3932
V+ +DEFT+DLFRFLQLLCEGHN+DFQN+LRTQ GNTTT+N+II TVDYLLRLQESISDF
Sbjct: 3725 VLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDF 3784
Query: 3933 YWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFL 3992
YWYYSGKD+I+E G+ NFSKA++V KQ+FNSLTEYIQGPC GNQQSLAHSRLWDAVVGFL
Sbjct: 3785 YWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFL 3844
Query: 3993 HVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSS 4052
HVFA+M MKL+QDSSQIELLKELLDL +DMVVMLLSLLEGNVVNG I +QMVD LVESS+
Sbjct: 3845 HVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESST 3904
Query: 4053 NVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLS 4112
NVEMILKFFDMFLKLKD+ S+ F++Y D +G+ISKK+FQKAM+ QKQ++ EI FLLS
Sbjct: 3905 NVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLS 3964
Query: 4113 CSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLELAESILEY 4172
C+EADEN+M N +F +RF EPA+DIGFNVAVLLTNLSEH+P+D RL L+ AES+L Y
Sbjct: 3965 CAEADENDMFNYVDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNY 4024
Query: 4173 FRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMEL 4232
F PYLGRIEIMG +++IER+YFEISE++R QWE PQVKESKRQFIFDVVNEGGE EKMEL
Sbjct: 4025 FEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMEL 4084
Query: 4233 FVSFCEDTIFEMQIAAQISEPEG--EPETDEDEGAGAAEAGAEGAEEGAAGLEGTAATAA 4290
FV+FCEDTIFEMQ+A+QISE + PE +E++ + G EE LE A+A
Sbjct: 4085 FVNFCEDTIFEMQLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLE--PASAF 4142
Query: 4291 AGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTRAGAAGAGA 4350
A A A V L+ + ++LR++ R ++++TA+E + + W
Sbjct: 4143 AMACASVKRNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLFTI 4202
Query: 4351 AAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDADGEGASE 4410
G +LW ++FGGGLVEGAK + VT++L MPDPT +H + + G +
Sbjct: 4203 LGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGITT 4262
Query: 4411 GAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTT-PAEPPTPE 4469
+G + + + + + G + GLGD+ + EPPT E
Sbjct: 4263 ELVHFIKGEKGDTDIMSDL------FGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLE 4316
Query: 4470 GSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPE--------- 4520
+ KRK + + E E ++E EKAD E+GEKE+ + +
Sbjct: 4317 STVQKKRK------AQAAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVT 4370
Query: 4521 PPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLF 4580
KK+ K E F+ LE+ + K L+YL+RNFY LRFLALF+AFAINFILLF
Sbjct: 4371 KKKKRRCGQKVEKPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLF 4430
Query: 4581 YKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYFLEESTGYM 4640
YKV++ P E+ DV+ W EE E+E MV++ L+ESTGYM
Sbjct: 4431 YKVTEEPLEEE------TEDVANL-------WNSFNDEE----EEEAMVFFVLQESTGYM 4473
Query: 4641 EPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKG 4700
P LR L+++HT+++ +C++GY CLKVPLV+FKREKE+ARKLEFDGLYITEQP +DD+KG
Sbjct: 4474 APTLRALAIIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKG 4533
Query: 4701 QWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEITAHNERKPN 4760
QWDRLV+NTPSFP+NYWDKFVKRKV++K+GD+YG ERIAELLG+D L+ + E K
Sbjct: 4534 QWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAE 4593
Query: 4761 PPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMG 4820
L++WL SID+KY IWK GV+FTDNSFLYL WY MS+LGHYNNFFFAAHLLDIAMG
Sbjct: 4594 -AASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMG 4652
Query: 4821 VKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDM 4880
KTLRTILSSVTHNGKQLV+TVGLLAVVVYLYTVVAFNFFRKFYNKSED+DEPDMKCDDM
Sbjct: 4653 FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDM 4712
Query: 4881 MTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDA 4940
MTCYLFHMYVGVRAGGGIGDEIEDPAGD YE+YR+VFDITFFFFVIVILLAIIQGLIIDA
Sbjct: 4713 MTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDA 4772
Query: 4941 FGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKD 5000
FGELRDQQEQV+EDMETKCFICGIG+DYFDTTPHGFETHTL+EHNLANY+FFLMYLINKD
Sbjct: 4773 FGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKD 4832
Query: 5001 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL 5037
ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL
Sbjct: 4833 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQL 4869
Score = 1896 bits (4911), Expect = 0.0
Identities = 906/1308 (69%), Positives = 1084/1308 (82%), Gaps = 20/1308 (1%)
Query: 2 GDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDL 61
G GEDE+QFLRT+DEVVLQC AT+ KEQ K CLAAEG GNRLCFLEPTS A+ +PPDL
Sbjct: 4 GGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDL 63
Query: 62 AICCFVLEQSLSVRALQEMLANTVEAGVE-SSQGGGHRTLLYGHAILLRHAHSRMYLSCL 120
+C FVLEQSLSVRALQEMLANT E G E ++QGGGHRTLLYGHA+LLRH+ S MYL+CL
Sbjct: 64 CVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAVLLRHSFSGMYLTCL 123
Query: 121 TTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVSVSSERYLH 180
TTSRS TDKLAFDVGL+E ATGEACWWT+HPASKQRSEGEKVR+GDD+ILVSVSSERYLH
Sbjct: 124 TTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLH 183
Query: 181 LSTASGELQVDASFMQTLWNMNPICS--RCEEGFVTGGHVLRLFHGHMDECLTISPADSD 238
LS ++G +QVDASFMQTLWN++P CS EEG++ GGHV+RLFHGH DECLTI D +
Sbjct: 184 LSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGH-DECLTIPSTDQN 242
Query: 239 D-QRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQYLALTEDQG 297
D Q R ++YE G T ARSLWR+EPLRISWSGS++RWGQ R+RH+TTG YLALTEDQG
Sbjct: 243 DSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQG 302
Query: 298 LVVVDASKAHTKATSFCFRISKE---KLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGL 354
L++ D +K+ TK+T+F FR SKE KLD + KRD+EGMG PEIKYG+S+CFVQH+ASGL
Sbjct: 303 LILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIASGL 362
Query: 355 WLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFI 414
W+TY A D K RLG LK+K +LHQEGHMDD L+L RCQ+EESQAAR+I +T L++QF+
Sbjct: 363 WVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFV 422
Query: 415 KSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQ 474
SG R + P LPIE V+ +LQDLI YF+PP E+++HE+KQ+KLRSL+NRQ
Sbjct: 423 ------SGNNRTAAP---ITLPIEEVLQTLQDLIAYFQPPEEEMRHEDKQNKLRSLKNRQ 473
Query: 475 SLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRS 534
+LF+EEGML++VLNCIDRLNVY + AHFA A EE+ +WKEI+NLLY+LLA+LIRGNR+
Sbjct: 474 NLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRN 533
Query: 535 NCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGR 594
NCA FS NLDWL+SKLDRLE+SSGILEVL+C+L ESPE LN+I E HIKSIISLLDKHGR
Sbjct: 534 NCAQFSNNLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGR 593
Query: 595 NHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEG 654
NHKVLD+LCSLC+CNGVAVR+NQ+LI +NLLP R LLLQT LIN VTSIRPNIF+G AEG
Sbjct: 594 NHKVLDILCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEG 653
Query: 655 TTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYG 714
+ QY KWYFE+++D+V PFLTA+ THLRVGWA + GY PYPG GEGWGGNGVGDDLYSYG
Sbjct: 654 SAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYG 713
Query: 715 FDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFESFNLDG 774
FDGLHLW+G + R V S QHLL +DV+SCCLDL VPSISFRING PVQG+FE+FN DG
Sbjct: 714 FDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDG 773
Query: 775 LFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPR 834
LFFPV+SFSAGVKVRFL+GGRHGEFKFLPP GYAPC+EA+LP+E++ LEP+KEY+R+
Sbjct: 774 LFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADG 833
Query: 835 GPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGP 894
L+G ++ LS F+PCPVDT Q++LPPHLE+IR++LAENIHELW + +IE GWT+G
Sbjct: 834 IRDLLGTTQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGK 893
Query: 895 VRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKL 954
+RDDNKR HPCLV+F LPE E+NYNLQMS ETLKTLLALGCH+ + AE++LKK KL
Sbjct: 894 IRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKL 953
Query: 955 PKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPA 1014
PK YMMSNGYKPAPLDLS V+L P Q LVD+LAEN HNVWA+DR+ QGW+Y QD+
Sbjct: 954 PKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKN 1013
Query: 1015 RRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQE--PSQVENQSRCDRVR 1072
+RNPRLVPY LLDE TK+SNRDSL +AVRT +GYGYNIEP DQE S VE S D++R
Sbjct: 1014 KRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSAVEKVS-IDKIR 1072
Query: 1073 IFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWH 1132
FR E+SY V+SG+WYFEFE VT G+MRVGWARP RPDVELGAD+ A+VF G+RGQRWH
Sbjct: 1073 FFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGNRGQRWH 1132
Query: 1133 LGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCS 1192
GS FGR WQPGDVVGCMI+L + ++IFTLNGE+L+++ GSE AF + EI +GF+P+C
Sbjct: 1133 QGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICC 1192
Query: 1193 LGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHP 1252
LG Q+G +NLG D S+ +F+ +CGLQEGFEPFA+NM R V WFSK LP F VP +HP
Sbjct: 1193 LGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHP 1252
Query: 1253 HYEVSRVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHF 1300
H EV R+DGT+D+PPCL++TH+T+G+QNS +M++ RLS+PV+ H F
Sbjct: 1253 HIEVMRIDGTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSF 1300
Score = 109 bits (273), Expect = 6e-23
Identities = 71/232 (30%), Positives = 111/232 (47%), Gaps = 20/232 (8%)
Query: 2731 AEGNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPM 2790
++ +F P PV+T VI+P L+ ++ AE HE W +KI+ W++G+ D+ + HP
Sbjct: 845 SQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPC 904
Query: 2791 LRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQTYD 2850
L + E +K E+LK ++A I EE +K K K Y
Sbjct: 905 LVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPK------NYM 958
Query: 2851 PREGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKK---------KQELEAKGGGT 2901
GY P P DLS V L + + ++LAEN HN W + + +Q+L+ K
Sbjct: 959 MSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNK---R 1015
Query: 2902 HPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEK 2953
+P LVPY L + K +R+ +E ++ GY + D EL S++EK
Sbjct: 1016 NPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEP--SDQELADSAVEK 1065
Score = 103 bits (258), Expect = 3e-21
Identities = 66/193 (34%), Positives = 101/193 (52%), Gaps = 12/193 (6%)
Query: 849 DFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVD 908
+F P P++T+ LP LE I K AE+ H+ WA + + GW YG D+N + HP +
Sbjct: 2597 NFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRP 2656
Query: 909 FHSLPEPERNYNLQMSGETLKTLLALGCHV-----GMADEKAEDNLKKTKLPKTYMMSNG 963
F +L E E+ + E+LKT+LA+G V G A + +N +K + N
Sbjct: 2657 FKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQREN-EKLRSVSQANQGNS 2715
Query: 964 YKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPY 1023
Y PAPLDLS+V L+ +V+ +AEN HN+WA+ + + ++ +P LVPY
Sbjct: 2716 YSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLE------LESKGGGSHPLLVPY 2769
Query: 1024 RLLDEATKRSNRD 1036
L K +R+
Sbjct: 2770 DTLTAKEKFKDRE 2782
Score = 52.0 bits (123), Expect = 1e-05
Identities = 25/102 (24%), Positives = 50/102 (49%)
Query: 964 YKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPY 1023
+ P P++ + L +V + AE+ H+ WA D+ GW Y D + +P + P+
Sbjct: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657
Query: 1024 RLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQ 1065
+ L E K R ++++T+L G+ +E + + V+ +
Sbjct: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQR 2699
>gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo
sapiens]
Length = 2701
Score = 167 bits (423), Expect = 2e-40
Identities = 93/292 (31%), Positives = 157/292 (53%), Gaps = 49/292 (16%)
Query: 4781 FGVIFTDNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLV 4839
+ + D +FLY Y+++ +LG + + FF++ L D+ +TL ++ SVT NG+ ++
Sbjct: 2337 YRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSII 2396
Query: 4840 MTVGLLAVVVYLYTVVAFNFFRKFYNKSED------------------------------ 4869
+T L ++VYL++++ F F + + D
Sbjct: 2397 LTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKEN 2456
Query: 4870 ---------------EDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELY- 4913
ED + CD ++ C + + G+R GGG+GD + P+ DE L+
Sbjct: 2457 CSPTIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDE-PLFA 2515
Query: 4914 -RVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTT 4972
RVV+D+ F+F VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD
Sbjct: 2516 ARVVYDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNK 2575
Query: 4973 PHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
FE H EHN+ +Y++F++ + KD TE+TG ESYV +M E+ D+FP
Sbjct: 2576 TVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFP 2627
Score = 101 bits (252), Expect = 2e-20
Identities = 138/595 (23%), Positives = 235/595 (39%), Gaps = 97/595 (16%)
Query: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATG-EACWWTMHPASKQRSEGE 160
Y + I L H S YL+ ++ +K A V L DA G E W+ +HP K RSEG+
Sbjct: 117 YSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSL--DAAGNEGSWFYIHPFWKLRSEGD 174
Query: 161 KVRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFV 213
+ VGD ++L+ V++ + LH S G +V+A T W + S E +
Sbjct: 175 NIVVGDKVVLMPVNAGQPLHASNIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVL 234
Query: 214 TGGHVLRLFHGHMDECLTISPADSDDQ--RRLVYYEGGAVCTHARSLWRLEPLRIS-WSG 270
GG V+RLFH ++ LT + R + T +++LW +E + G
Sbjct: 235 KGGDVVRLFHAEQEKFLTCDEYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRG 294
Query: 271 SHLRWGQPLRVRHVTTGQYLAL--------TEDQGLVVVD-----ASKAHTKATSFCFRI 317
+W R +H+ TG YLA +++G V D + K + +
Sbjct: 295 GAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTL 354
Query: 318 ----------SKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAA------- 360
S +LD + + + P S ++H+ + W+T +
Sbjct: 355 VSVPHGNDIASLFELDATTLQRADCLVP-----RNSYVRLRHLCTNTWVTSTSIPIDTDE 409
Query: 361 PDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSF 420
P L++G + K +A ++ E + + N + +K L++
Sbjct: 410 ERPVMLKIGTCQTK-------EDKEAFAIVSVPLSEVRDLDFANDANKVLATTVKKLEN- 461
Query: 421 SGKPRGSGPPAGTALPIEG--VILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQ 478
GT E V L+DLI + + Q + R RQ L +
Sbjct: 462 -----------GTITQNERRFVTKLLEDLIFFVADVPNNGQEVLDVVITKPNRERQKLMR 510
Query: 479 EEGMLSMVLNCIDRLNVYTTAAHFAEFAGE-----------EAAESWKEIVNLLYELLAS 527
E+ +L+ V + A F E AGE + +K ++ L Y +L
Sbjct: 511 EQNILAQVFGIL--------KAPFKEKAGEGSMLRLEDLGDQRYAPYKYMLRLCYRVLRH 562
Query: 528 LIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSI 585
+ R N + N + S++ + E L+ + L I I++
Sbjct: 563 SQQDYRKNQEYIAKNFCVMQSQI----GYDILAEDTITALLHNNRKLLEKHITAKEIETF 618
Query: 586 ISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLL-PGR-ELLLQTNLIN 638
+SLL + R + LD L LCV N A+ Q+LI + +L PG ++L+QT +++
Sbjct: 619 VSLL-RRNREPRFLDYLSDLCVSNTTAIPVTQELICKFMLSPGNADILIQTKVVS 672
Score = 74.3 bits (181), Expect = 3e-12
Identities = 127/548 (23%), Positives = 209/548 (38%), Gaps = 153/548 (27%)
Query: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKD-KKE 3824
Q L GA+E+V+ +I K + + S + LGI++L GGN + Q L + KK
Sbjct: 1746 QCLLDKEGASELVIDVIVNTKNDR--IFSEGIFLGIALLEGGNTQTQYSFYQQLHEQKKS 1803
Query: 3825 VGFFQSIQALMQTC-----SVLDLNAFERQNKA------------------------EGL 3855
FF+ + M+ S + +N + NK EG+
Sbjct: 1804 EKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTSGPRMRVRDSTLHLKEGM 1863
Query: 3856 -GMVNEDGTVINRQ----------------------NGEKVMADD-------EFTQDLFR 3885
G + E + ++ N E+ A++ Q + R
Sbjct: 1864 KGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSAEEVTMSPAIAIMQPILR 1923
Query: 3886 FLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQ 3945
FLQLLCE HN + QN+LR Q N T N++ T+ +L + S + G ++
Sbjct: 1924 FLQLLCENHNRELQNFLRNQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL--- 1973
Query: 3946 GKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLA--HSRLWDAVVGFLHVFAHMMMKLA 4003
G K +++ Q SLTEY QGPC NQ +A S D ++ + + + K
Sbjct: 1974 GLYINEKNVALVNQNLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYR 2033
Query: 4004 QDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDM 4063
D +L L+ + +LL+++E S N E IL F+M
Sbjct: 2034 MDL--------VLQLKNNASKLLLAIMESR---------------HDSENAERIL--FNM 2068
Query: 4064 FLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMIN 4123
PR L+ D K +Q L C D
Sbjct: 2069 ------------------RPRELV---DVMKNAYNQG----------LECDHGD------ 2091
Query: 4124 CEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFL------ELAESILEYFRPYL 4177
+E + P +D+G N+ +L L+ H+ L L + + L+Y+ +
Sbjct: 2092 -DEGGDDGVSP-KDVGHNIYILAHQLAR---HNKLLQQMLKPGSDPDEGDEALKYYANHT 2146
Query: 4178 GRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFC 4237
+IEI+ R +E+I F + N ++ +ESK + +F+ + K+ F
Sbjct: 2147 AQIEIVRHDRTMEQIVFPV--PNICEY---LTRESKCR-VFNTTERDEQGSKVNDFFQQT 2200
Query: 4238 EDTIFEMQ 4245
ED EM+
Sbjct: 2201 EDLYNEMK 2208
Score = 46.6 bits (109), Expect = 6e-04
Identities = 32/143 (22%), Positives = 66/143 (46%), Gaps = 6/143 (4%)
Query: 490 IDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFSTNLDWLVSK 549
+ + ++ + E+ E E++NL + L + RGN N L +L+ ++
Sbjct: 1207 LKNMGAHSVVLDLLQIPYEKNDEKMNEVMNLAHTFLQNFCRGNPQNQVLLHKHLNLFLTP 1266
Query: 550 LDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCN 609
LEA E + + + + + N I E ++ + ++ HGR+ + L L ++ +
Sbjct: 1267 -GLLEA-----ETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKAD 1320
Query: 610 GVAVRSNQDLITENLLPGRELLL 632
G V+ QD++ L+ G E +L
Sbjct: 1321 GKYVKKCQDMVMTELINGGEDVL 1343
Score = 34.7 bits (78), Expect = 2.5
Identities = 20/74 (27%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 2185 IMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISR 2244
+ N K QH L++ +G H V++++ E + + +++ FL FCR +
Sbjct: 1194 VQNKKCRNQHQRLLKNMGAHSVVLDLLQIPY---EKNDEKMNEVMNLAHTFLQNFCRGNP 1250
Query: 2245 QNQRSMFDHLSYLL 2258
QNQ + HL+ L
Sbjct: 1251 QNQVLLHKHLNLFL 1264
>gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isoform 1
[Homo sapiens]
Length = 2710
Score = 166 bits (419), Expect = 7e-40
Identities = 93/289 (32%), Positives = 156/289 (53%), Gaps = 52/289 (17%)
Query: 4787 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4845
D FLY Y+V+ +G + + FF++ L D+ +TL ++ SVT NG+ +++T L
Sbjct: 2349 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2408
Query: 4846 AVVVYLYTVVAFNFFR-------------------------------------------- 4861
++VYL+++V + FF+
Sbjct: 2409 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2468
Query: 4862 ----KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELY--RV 4915
+ E E + + C+ ++ C + + G+R+GGG+GD + P+ +E L+ RV
Sbjct: 2469 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE-PLFAARV 2527
Query: 4916 VFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHG 4975
++D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD
Sbjct: 2528 IYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVT 2587
Query: 4976 FETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
FE H EEHN+ +Y+ F++ + KD TE+TG ESYV +M +ER D+FP
Sbjct: 2588 FEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2636
Score = 82.4 bits (202), Expect = 1e-14
Identities = 129/585 (22%), Positives = 232/585 (39%), Gaps = 79/585 (13%)
Query: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEK 161
YG+ I L H S YL+ ++ +K A V L E A E W+ + P K RS G+
Sbjct: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
Query: 162 VRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFVT 214
V +GD ++L V++ + LH S+ G +V++ T W + S ++ +
Sbjct: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
Query: 215 GGHVLRLFHGHMDECLTISPADSDDQRRLVYY-----EGGAVCTHARSLWRLEPLRIS-W 268
GG V+RLFH ++ LT D +++ V+ + T +++LW +E ++
Sbjct: 236 GGDVVRLFHAEQEKFLT---CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPC 292
Query: 269 SGSHLRWGQPLRVRHVTTGQYLALT-----EDQGLVVVDASKAHTKATSFCFRISKEKL- 322
G W R +H+ TG YLA E++ L + A+ R ++EK+
Sbjct: 293 RGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMV 352
Query: 323 ----DVAPKRDVEG---MGPPEIKYGESL------CFVQHVASGLW-------LTYAAPD 362
V D+ + P ++ G+SL ++H+ + W +
Sbjct: 353 YSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEK 412
Query: 363 PKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSFSG 422
P L++G K +A ++ E + N K L S +G
Sbjct: 413 PVMLKIGTSPVK-------EDKEAFAIVPVSPAEVRDL-------DFANDASKVLGSIAG 458
Query: 423 KPRGSGPPAGTALPIE--GVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEE 480
K GT E V L+DL+ + + Q + + R RQ L +E+
Sbjct: 459 KLE-----KGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQ 513
Query: 481 GMLSMVLNCIDRLNVYTTAAH----FAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNC 536
+L + + +T E G++ ++ I L Y +L + R N
Sbjct: 514 NILKQIFKLLQA--PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQ 571
Query: 537 ALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSIISLLDKHGR 594
+ ++ ++ + E L+ + L I I + +SL+ K+ R
Sbjct: 572 EYIAKQFGFMQKQI----GYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKN-R 626
Query: 595 NHKVLDVLCSLCVCNGVAVRSNQDLITENLL--PGRELLLQTNLI 637
+ LD L LCV ++ Q+LI + +L ++L++T L+
Sbjct: 627 EPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 671
Score = 70.9 bits (172), Expect = 3e-11
Identities = 120/542 (22%), Positives = 205/542 (37%), Gaps = 146/542 (26%)
Query: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3824
Q L GA+ +V+ +I + + ++ L I++L GGN +Q L +DKK
Sbjct: 1756 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1813
Query: 3825 VGFFQSI--------QALMQTCSV-------------LDLNAFERQNKAEGLGMVNEDG- 3862
FF+ Q + T +V +D +A R+ E + E+
Sbjct: 1814 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1873
Query: 3863 --------------TVINR--------QNGEKVMADDEFTQD-------------LFRFL 3887
T R Q GE A + +D + RFL
Sbjct: 1874 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1933
Query: 3888 QLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGK 3947
QLLCE HN D QN+LR Q N T N++ T+ +L + S + G ++ G
Sbjct: 1934 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1983
Query: 3948 RNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSS 4007
K +++ Q SLTEY QGPC NQ +A +S+
Sbjct: 1984 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2021
Query: 4008 QIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKL 4067
I+++ L+ N +N + ++ +D+++E +N +L
Sbjct: 2022 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2056
Query: 4068 KDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEF 4127
+ E+ D R L + + + +K + E++F ++ E N E+
Sbjct: 2057 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-------EDGE--NGEDG 2105
Query: 4128 ANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLEL-----AESILEYFRPYLGRIEI 4182
A R++G N+ +L L+ H+ L + L+ + LE++ + +IEI
Sbjct: 2106 A----ASPRNVGHNIYILAHQLAR---HNKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2158
Query: 4183 MGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIF 4242
+ R +E+I F + KESK + I+ + K+ F ED
Sbjct: 2159 VRLDRTMEQIVFPVPSICEF-----LTKESKLR-IYYTTERDEQGSKINDFFLRSEDLFN 2212
Query: 4243 EM 4244
EM
Sbjct: 2213 EM 2214
Score = 43.9 bits (102), Expect = 0.004
Identities = 38/175 (21%), Positives = 81/175 (46%), Gaps = 24/175 (13%)
Query: 461 EEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAES-WKEIVN 519
+E S +S + +Q L + G ++VL + + E+A ++ +EI+
Sbjct: 1190 QESASVRKSRKQQQRLLRNMGAHAVVLELL-------------QIPYEKAEDTKMQEIMR 1236
Query: 520 LLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYC--VLIESPEVLNII 577
L +E L + GN+ N AL +++ L + GILE + + + + ++ + I
Sbjct: 1237 LAHEFLQNFCAGNQQNQALLHKHIN--------LFLNPGILEAVTMQHIFMNNFQLCSEI 1288
Query: 578 QENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLL 632
E ++ + ++ HGRN + + L ++ G ++ QD++ L+ E +L
Sbjct: 1289 NERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVL 1343
>gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isoform 2
[Homo sapiens]
Length = 2695
Score = 166 bits (419), Expect = 7e-40
Identities = 93/289 (32%), Positives = 156/289 (53%), Gaps = 52/289 (17%)
Query: 4787 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4845
D FLY Y+V+ +G + + FF++ L D+ +TL ++ SVT NG+ +++T L
Sbjct: 2334 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2393
Query: 4846 AVVVYLYTVVAFNFFR-------------------------------------------- 4861
++VYL+++V + FF+
Sbjct: 2394 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2453
Query: 4862 ----KFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELY--RV 4915
+ E E + + C+ ++ C + + G+R+GGG+GD + P+ +E L+ RV
Sbjct: 2454 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE-PLFAARV 2512
Query: 4916 VFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHG 4975
++D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD
Sbjct: 2513 IYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVT 2572
Query: 4976 FETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
FE H EEHN+ +Y+ F++ + KD TE+TG ESYV +M +ER D+FP
Sbjct: 2573 FEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2621
Score = 84.0 bits (206), Expect = 4e-15
Identities = 130/580 (22%), Positives = 231/580 (39%), Gaps = 84/580 (14%)
Query: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEK 161
YG+ I L H S YL+ ++ +K A V L E A E W+ + P K RS G+
Sbjct: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
Query: 162 VRVGDDIILVSVSSERYLHLSTAS-----GELQVDASFMQTLWNMNPIC--SRCEEGFVT 214
V +GD ++L V++ + LH S+ G +V++ T W + S ++ +
Sbjct: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
Query: 215 GGHVLRLFHGHMDECLTISPADSDDQRRLVYY-----EGGAVCTHARSLWRLEPLRIS-W 268
GG V+RLFH ++ LT D +++ V+ + T +++LW +E ++
Sbjct: 236 GGDVVRLFHAEQEKFLT---CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPC 292
Query: 269 SGSHLRWGQPLRVRHVTTGQYLALTEDQGLVVVDASKAHTKATSFCFRISKEKL-----D 323
G W R +H+ TG YLA D DAS++ R ++EK+
Sbjct: 293 RGGAGYWNSLFRFKHLATGHYLAAEVDPD---QDASRSR-------LRNAQEKMVYSLVS 342
Query: 324 VAPKRDVEG---MGPPEIKYGESL------CFVQHVASGLW-------LTYAAPDPKALR 367
V D+ + P ++ G+SL ++H+ + W + P L+
Sbjct: 343 VPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLK 402
Query: 368 LGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQFIKSLDSFSGKPRGS 427
+G K +A ++ E + N K L S +GK
Sbjct: 403 IGTSPVK-------EDKEAFAIVPVSPAEVRDL-------DFANDASKVLGSIAGKLE-- 446
Query: 428 GPPAGTALPIE--GVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEGMLSM 485
GT E V L+DL+ + + Q + + R RQ L +E+ +L
Sbjct: 447 ---KGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQ 503
Query: 486 VLNCIDRLNVYTTAAH----FAEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFST 541
+ + +T E G++ ++ I L Y +L + R N +
Sbjct: 504 IFKLLQA--PFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAK 561
Query: 542 NLDWLVSKLDRLEASSGILEVLYCVLIESPEVL--NIIQENHIKSIISLLDKHGRNHKVL 599
++ ++ + E L+ + L I I + +SL+ K+ R + L
Sbjct: 562 QFGFMQKQI----GYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKN-REPRFL 616
Query: 600 DVLCSLCVCNGVAVRSNQDLITENLL--PGRELLLQTNLI 637
D L LCV ++ Q+LI + +L ++L++T L+
Sbjct: 617 DYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 656
Score = 70.9 bits (172), Expect = 3e-11
Identities = 120/542 (22%), Positives = 205/542 (37%), Gaps = 146/542 (26%)
Query: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3824
Q L GA+ +V+ +I + + ++ L I++L GGN +Q L +DKK
Sbjct: 1741 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1798
Query: 3825 VGFFQSI--------QALMQTCSV-------------LDLNAFERQNKAEGLGMVNEDG- 3862
FF+ Q + T +V +D +A R+ E + E+
Sbjct: 1799 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1858
Query: 3863 --------------TVINR--------QNGEKVMADDEFTQD-------------LFRFL 3887
T R Q GE A + +D + RFL
Sbjct: 1859 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1918
Query: 3888 QLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGK 3947
QLLCE HN D QN+LR Q N T N++ T+ +L + S + G ++ G
Sbjct: 1919 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1968
Query: 3948 RNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSS 4007
K +++ Q SLTEY QGPC NQ +A +S+
Sbjct: 1969 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2006
Query: 4008 QIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKL 4067
I+++ L+ N +N + ++ +D+++E +N +L
Sbjct: 2007 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2041
Query: 4068 KDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFLLSCSEADENEMINCEEF 4127
+ E+ D R L + + + +K + E++F ++ E N E+
Sbjct: 2042 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-------EDGE--NGEDG 2090
Query: 4128 ANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLEL-----AESILEYFRPYLGRIEI 4182
A R++G N+ +L L+ H+ L + L+ + LE++ + +IEI
Sbjct: 2091 A----ASPRNVGHNIYILAHQLAR---HNKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2143
Query: 4183 MGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIF 4242
+ R +E+I F + KESK + I+ + K+ F ED
Sbjct: 2144 VRLDRTMEQIVFPVPSICEF-----LTKESKLR-IYYTTERDEQGSKINDFFLRSEDLFN 2197
Query: 4243 EM 4244
EM
Sbjct: 2198 EM 2199
Score = 43.9 bits (102), Expect = 0.004
Identities = 38/175 (21%), Positives = 81/175 (46%), Gaps = 24/175 (13%)
Query: 461 EEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAES-WKEIVN 519
+E S +S + +Q L + G ++VL + + E+A ++ +EI+
Sbjct: 1175 QESASVRKSRKQQQRLLRNMGAHAVVLELL-------------QIPYEKAEDTKMQEIMR 1221
Query: 520 LLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYC--VLIESPEVLNII 577
L +E L + GN+ N AL +++ L + GILE + + + + ++ + I
Sbjct: 1222 LAHEFLQNFCAGNQQNQALLHKHIN--------LFLNPGILEAVTMQHIFMNNFQLCSEI 1273
Query: 578 QENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLL 632
E ++ + ++ HGRN + + L ++ G ++ QD++ L+ E +L
Sbjct: 1274 NERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVL 1328
>gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo
sapiens]
Length = 2671
Score = 161 bits (407), Expect = 2e-38
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 51/288 (17%)
Query: 4787 DNSFLYLGWYMVMSLLGHY-NNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLL 4845
D FLY Y++ S+LG + + F++ L D+ +TL ++ SVT NG+ +++T L
Sbjct: 2317 DMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLA 2376
Query: 4846 AVVVYLYTVVAFNFFRKFY----------------------------------------- 4864
++VYL+++V F F + +
Sbjct: 2377 LILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGL 2436
Query: 4865 ------NKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELY--RVV 4916
+ + D + CD ++ C + M G+R GGG+GD + P+ DE L+ RVV
Sbjct: 2437 SVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDE-SLFPARVV 2495
Query: 4917 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGF 4976
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 2496 YDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSF 2555
Query: 4977 ETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 5024
E H EHN+ NY++F++ + K++T++TG ESYV +M + + D+FP
Sbjct: 2556 EEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFP 2603
Score = 88.2 bits (217), Expect = 2e-16
Identities = 137/589 (23%), Positives = 233/589 (39%), Gaps = 90/589 (15%)
Query: 102 YGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATG-EACWWTMHPASKQRSEGE 160
YG I L H S YL+ ++ +K A V L DATG E W + P K RS G+
Sbjct: 118 YGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTL--DATGNEGSWLFIQPFWKLRSNGD 175
Query: 161 KVRVGDDIILVSVSSERYLH-----LSTASGELQVDASFMQTLWNMNPICSRCE--EGFV 213
V VGD +IL V++ + LH LS +G +V++ T W +N + E +
Sbjct: 176 NVVVGDKVILNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVL 235
Query: 214 TGGHVLRLFHGHMDECLTISPADSDDQ--RRLVYYEGGAVCTHARSLWRLEPLRIS-WSG 270
GG V+RLFH ++ LT Q R + T + +LW +E + G
Sbjct: 236 KGGDVVRLFHAEQEKFLTCDEYKGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRG 295
Query: 271 SHLRWGQPLRVRHVTTGQYLALTEDQGLVVVDASKAHT---------------KATSFCF 315
W R +H+ TG YLA E+ DAS + +C
Sbjct: 296 GAGHWNGLYRFKHLATGNYLA-AEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCL 354
Query: 316 RISKEKLDVAPKRDVEGMGPPEIKYGESLC------FVQHVASGLWL--TYAAPD----- 362
D+A +++ P ++ +S ++H+ + W+ T D
Sbjct: 355 VAVPHGNDIASLFELD---PTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEER 411
Query: 363 PKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGLYNQ-FIKSLDSFS 421
P L LG K + +S R + A+ M+ S N+ FI D
Sbjct: 412 PIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDR-- 469
Query: 422 GKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRSLRNRQSLFQEEG 481
VI L+DL+ + + Q+ + R RQ L +E+
Sbjct: 470 ----------------RFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQN 513
Query: 482 MLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNL-------LYELLASLIRGNRS 534
+L V + A F E GE +E+ + ++ L ++R ++
Sbjct: 514 ILKQVFGILK--------APFREKGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQE 565
Query: 535 NCALFSTNLDWLVSKLDRLEASSG---ILEVLYCVLIESPEVL--NIIQENHIKSIISLL 589
+ + N + + + +++ G + E L+ + L I + +++ +SL+
Sbjct: 566 D---YRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLV 622
Query: 590 DKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGR--ELLLQTNL 636
K+ R + LD L LCV N +A+ Q+LI + +L + ++L++T L
Sbjct: 623 RKN-REPRFLDYLSDLCVSNHIAIPVTQELICKCVLDPKNSDILIRTEL 670
Score = 72.4 bits (176), Expect = 1e-11
Identities = 68/247 (27%), Positives = 108/247 (43%), Gaps = 51/247 (20%)
Query: 3766 QARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYL-KDKKE 3824
Q RL GA ++V +I++ K E + ++ L I +L+GGN E+Q+ + + DKK
Sbjct: 1725 QCRLDKEGATKLVCDLITSTKNEK--IFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKS 1782
Query: 3825 VGFFQSI-----QALMQTCSVLDLNAFERQNKAE--------------------GLGMVN 3859
FF+ + +A +T S + +N + ++ G
Sbjct: 1783 ERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRY 1842
Query: 3860 EDGTVINRQN--GEKVMADDEFT-----QDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTI 3912
G + R + E+V + + T Q + RFLQLLCE HN D QN+LR Q N T
Sbjct: 1843 SLGPSLRRGHEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NNKTNY 1901
Query: 3913 NIIICTVDYLLRLQESIS---DFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQ 3969
N++ T+ +L + S + Y +D + + Q +LTEY Q
Sbjct: 1902 NLVCETLQFLDIMCGSTTGGLGLLGLYINEDNV------------GLVIQTLETLTEYCQ 1949
Query: 3970 GPCTGNQ 3976
GPC NQ
Sbjct: 1950 GPCHENQ 1956
Score = 37.7 bits (86), Expect = 0.29
Identities = 29/109 (26%), Positives = 51/109 (46%), Gaps = 6/109 (5%)
Query: 516 EIVNLLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLN 575
EI+ ++ L GN N AL +L ++ LEA E + + + + ++ +
Sbjct: 1223 EILRYTHQFLQKFCAGNPGNQALLHKHLHLFLTP-GLLEA-----ETMQHIFLNNYQLCS 1276
Query: 576 IIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENL 624
I E ++ + LL HGR+ + LD L ++ G V+ QD+I L
Sbjct: 1277 EISEPVLQHFVHLLATHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTEL 1325
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 78.2 bits (191), Expect = 2e-13
Identities = 55/148 (37%), Positives = 75/148 (50%), Gaps = 16/148 (10%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQ---- 1928
EE+EEE+EEEE EEEDEEE+EE+EEE +E+E+EE+EEEE E E+EE + + Q
Sbjct: 259 EEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTS 318
Query: 1929 ----MKLPE-------SVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRY 1977
K PE S K + ++E D + S + + R
Sbjct: 319 HTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNL 378
Query: 1978 GLLIKAFSMTAAETARRTREFRSPPQEQ 2005
GLL +A ++ AE R E PP EQ
Sbjct: 379 GLLEQAIAL-KAEQVRTVCEPGCPPAEQ 405
Score = 58.2 bits (139), Expect = 2e-07
Identities = 30/61 (49%), Positives = 41/61 (67%), Gaps = 4/61 (6%)
Query: 1868 PEVFTEEEEEEDEEEEG----EEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLE 1923
P+ + EE +++G EEEDEEE+EE+EEE E+E+EE+EEEE E E+EE E
Sbjct: 237 PQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEE 296
Query: 1924 E 1924
E
Sbjct: 297 E 297
Score = 38.1 bits (87), Expect = 0.22
Identities = 40/131 (30%), Positives = 54/131 (41%), Gaps = 13/131 (9%)
Query: 4405 GEGASEGAG------DAAEGAGDEE-EAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDM 4457
G+ A G G +AAEGA EE E P A+ V VT E + L
Sbjct: 185 GQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTT------ERSQDLCPQ 238
Query: 4458 GDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEP 4517
A + + IL + + EEE E E E E E E E+ + E E+EE E
Sbjct: 239 SLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEE 298
Query: 4518 TPEPPKKQAPP 4528
E +++A P
Sbjct: 299 EEEEEEEEAAP 309
Score = 37.0 bits (84), Expect = 0.50
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 6/68 (8%)
Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG 1916
ED ++++++ T E ++ + E+ EE + + + E+EDEE+EEEE E
Sbjct: 219 EDAEEVVEV------TTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEE 272
Query: 1917 EKEEGLEE 1924
E EE EE
Sbjct: 273 EDEEEEEE 280
Score = 34.3 bits (77), Expect = 3.2
Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 14/66 (21%)
Query: 4484 EEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPE--------------PPKKQAPPS 4529
+EE E E E E E E E+ + E E+EE E P+ P+ + P S
Sbjct: 274 DEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPES 333
Query: 4530 PPPKKE 4535
P PK E
Sbjct: 334 PSPKPE 339
>gi|37588869 ring finger protein 123 [Homo sapiens]
Length = 1314
Score = 70.9 bits (172), Expect = 3e-11
Identities = 39/127 (30%), Positives = 65/127 (51%), Gaps = 10/127 (7%)
Query: 1082 VQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADEL--AYVFNGHRGQRWHLGSEPFG 1139
V G+W +E + G M++GW R + E G + +Y ++G+R ++W++ + +G
Sbjct: 130 VYKGKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYG 189
Query: 1140 RPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIE--IGDGFLPVCSLGPGQ 1197
+ W GD+V C+IDL + T+ F LNG L TAF + +G + P SL +
Sbjct: 190 KAWAAGDIVSCLIDLDDGTLSFCLNGVSL------GTAFENLSRGLGMAYFPAISLSFKE 243
Query: 1198 VGHLNLG 1204
N G
Sbjct: 244 SVAFNFG 250
Score = 49.3 bits (116), Expect = 1e-04
Identities = 36/110 (32%), Positives = 54/110 (49%), Gaps = 8/110 (7%)
Query: 705 GVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQ 764
GVGD SY +DG + +V T+ G+ A D++SC +DL ++SF +NG +
Sbjct: 163 GVGDTHNSYAYDGNRVRKWNVT--TTNYGK-AWAAGDIVSCLIDLDDGTLSFCLNGVSLG 219
Query: 765 GVFESFN--LDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHE 812
FE+ + L +FP +S S V F G R + P GY P +
Sbjct: 220 TAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRY---PVAGYRPLQD 266
>gi|45387949 ring finger and SPRY domain containing 1 [Homo sapiens]
Length = 576
Score = 68.6 bits (166), Expect = 2e-10
Identities = 38/110 (34%), Positives = 59/110 (53%), Gaps = 6/110 (5%)
Query: 1065 QSRCDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELR----PDVELGADELA 1120
++RCD ++ V +G WY+E VT+G M++GWA + + +G DE +
Sbjct: 339 EARCDASSFESVRCTFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYS 398
Query: 1121 YVFNGHRGQRWH-LGSEPFGRP-WQPGDVVGCMIDLTENTIIFTLNGEVL 1168
++G R W+ S+P P W+ GD VG ++DL E +IF LNG L
Sbjct: 399 CAYDGCRQLIWYNARSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQL 448
Score = 40.8 bits (94), Expect = 0.034
Identities = 45/173 (26%), Positives = 71/173 (41%), Gaps = 35/173 (20%)
Query: 661 WYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLH- 719
WY+EV V + +++GWA + G G+GDD YS +DG
Sbjct: 361 WYYEVTV--------VTSGVMQIGWATRDSKFL------NHEGYGIGDDEYSCAYDGCRQ 406
Query: 720 -LWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRING---CPVQGVFESFNLDGL 775
+W ++P P D + LDL+ + F +NG P + VF S + G
Sbjct: 407 LIWYNARSKPHIHP---CWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSS-TVSG- 461
Query: 776 FFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHE---------AVLPRER 819
FF SF + + F G + FK+ P ++ ++ +LPR R
Sbjct: 462 FFAAASFMSYQQCEFNFGAK--PFKYPPSMKFSTFNDYAFLTAEEKIILPRHR 512
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 67.0 bits (162), Expect = 4e-10
Identities = 43/80 (53%), Positives = 54/80 (67%), Gaps = 3/80 (3%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG-LEEG 1925
E E EEEEEE+EEEE EEED EE+EEDEEE +E+E+EE+E EE E E+EEG LEE
Sbjct: 888 EEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEE--EFEEEEGELEEE 945
Query: 1926 LLQMKLPESVKLQMCHLLEY 1945
+ E +L+ LE+
Sbjct: 946 EEEEDEEEEEELEEVEDLEF 965
Score = 64.7 bits (156), Expect = 2e-09
Identities = 37/74 (50%), Positives = 49/74 (66%)
Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
G +++ L +I EEEEEE+EEEE EEE+EEE+E+ EEE E+E E+EEEE
Sbjct: 870 GPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEE 929
Query: 1915 EGEKEEGLEEGLLQ 1928
E E+E EEG L+
Sbjct: 930 EFEEEFEEEEGELE 943
Score = 62.0 bits (149), Expect = 1e-08
Identities = 40/86 (46%), Positives = 55/86 (63%), Gaps = 5/86 (5%)
Query: 1844 LVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDE--EEKEEDEEETAQ 1901
L L V+ I ++ ++ + E E EEEEEED EEE E+E+E EE+EE+EEE +
Sbjct: 874 LEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEE 933
Query: 1902 EKEDEE---KEEEEAAEGEKEEGLEE 1924
E E+EE +EEEE + E+EE LEE
Sbjct: 934 EFEEEEGELEEEEEEEDEEEEEELEE 959
Score = 60.1 bits (144), Expect = 5e-08
Identities = 34/61 (55%), Positives = 44/61 (72%), Gaps = 2/61 (3%)
Query: 1867 EPEVFTEEEEEEDE--EEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
E E F EEEE+E+E EEE EEE+E E+E +EEE E+E+EE++EEE E E+ E LE
Sbjct: 906 EEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEF 965
Query: 1925 G 1925
G
Sbjct: 966 G 966
Score = 56.2 bits (134), Expect = 8e-07
Identities = 32/59 (54%), Positives = 40/59 (67%), Gaps = 4/59 (6%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEE----AAEGEKEEG 1921
E E F EEEEEE+E EE EE+E E EE+EEE +E+E+E +E E+ A GE EEG
Sbjct: 917 EEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEG 975
Score = 42.4 bits (98), Expect = 0.012
Identities = 38/132 (28%), Positives = 53/132 (40%), Gaps = 8/132 (6%)
Query: 4410 EGAGDAAEGAGDEEEA-----VHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAE 4464
EG + E DEEE V + G A G V +G P P L ++ P
Sbjct: 939 EGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVE--EGAPPPPTLPPALPPP-ESPPKV 995
Query: 4465 PPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEPPKK 4524
P PE P L ++ G EEE + P PE P + + E + P P+ +
Sbjct: 996 QPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVE 1055
Query: 4525 QAPPSPPPKKEE 4536
+ P +PP EE
Sbjct: 1056 EEPSAPPTLLEE 1067
Score = 35.0 bits (79), Expect = 1.9
Identities = 26/93 (27%), Positives = 45/93 (48%), Gaps = 8/93 (8%)
Query: 3670 EDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIM 3729
ED + +++ + E+EEEEEE EE++ + + E+ + +E+Y +
Sbjct: 876 EDLTVININSSDEEEEEEEEEEEEEEEEEEE------EEDFEEEEEDEEEYFEEEEEEEE 929
Query: 3730 AKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRL 3762
EE E GE EEE E EE++ E + +
Sbjct: 930 EFEEEFEE--EEGELEEEEEEEDEEEEEELEEV 960
Score = 33.1 bits (74), Expect = 7.2
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 1/51 (1%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDE 1906
+E+ ++ + E E EEEEE+E+EE EEE+ EE E+ E TA + +E
Sbjct: 925 EEEEEEFEEEFEEEEGELEEEEEEEDEE-EEEELEEVEDLEFGTAGGEVEE 974
Score = 33.1 bits (74), Expect = 7.2
Identities = 25/66 (37%), Positives = 29/66 (43%), Gaps = 1/66 (1%)
Query: 4484 EEELPPEPEPEPEPELEPEKADAENGEKEE-VPEPTPEPPKKQAPPSPPPKKEEAGGEFW 4542
EEE E E E E+E + GE EE P P PP P SPP + E E
Sbjct: 945 EEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPG 1004
Query: 4543 GELEVQ 4548
LEV+
Sbjct: 1005 LLLEVE 1010
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 67.0 bits (162), Expect = 4e-10
Identities = 30/52 (57%), Positives = 44/52 (84%)
Query: 1863 LKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
L ++P+ +EEEEE+EE+E EEE++EE+EE+EEE +E+E+EE+EEEEAA
Sbjct: 722 LAPVQPQANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAA 773
Score = 65.1 bits (157), Expect = 2e-09
Identities = 30/42 (71%), Positives = 38/42 (90%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
EEEEEE+E+EE EEEDEEE+EE+EEE +E+E+EE+EEE AA
Sbjct: 733 EEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAA 774
Score = 45.8 bits (107), Expect = 0.001
Identities = 31/86 (36%), Positives = 42/86 (48%), Gaps = 6/86 (6%)
Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEE------ETAQEKEDEEK 1908
G E+ ++ + E E EEEEEE+EEEE EEE+EEE+EE+ E +
Sbjct: 731 GKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAAAAVALGEVLGPRSGSSS 790
Query: 1909 EEEEAAEGEKEEGLEEGLLQMKLPES 1934
E E + +EG LL ES
Sbjct: 791 EGSERSTDRSQEGAPSTLLADDQKES 816
>gi|169210053 PREDICTED: hypothetical protein [Homo sapiens]
Length = 185
Score = 66.2 bits (160), Expect = 8e-10
Identities = 36/54 (66%), Positives = 41/54 (75%), Gaps = 2/54 (3%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEK--EEGLEE 1924
EEE EE+EEE EEE EEEKEEDEEE +E+E EE EEEE EG+K EE +EE
Sbjct: 120 EEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEE 173
Score = 59.7 bits (143), Expect = 7e-08
Identities = 30/64 (46%), Positives = 47/64 (73%)
Query: 1860 KQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKE 1919
+Q L + E EV EEEE E+EE+E E+E++EE+EE EEE +++E+EEKE ++ E + E
Sbjct: 113 QQGLPVEEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVE 172
Query: 1920 EGLE 1923
E ++
Sbjct: 173 EEID 176
Score = 54.7 bits (130), Expect = 2e-06
Identities = 29/67 (43%), Positives = 48/67 (71%), Gaps = 1/67 (1%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
+E+V++ + +E E EEE+EEDEEEE +EE++EE EE+EE+ ++ E+E+ EEE E
Sbjct: 120 EEEVEEEEEEVEEEE-KEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEEEIDTE 178
Query: 1916 GEKEEGL 1922
++ + L
Sbjct: 179 IQRTQYL 185
Score = 49.7 bits (117), Expect = 7e-05
Identities = 30/65 (46%), Positives = 40/65 (61%), Gaps = 3/65 (4%)
Query: 1877 EEDEEEEG---EEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPE 1933
EE ++G EEE+ EE+EE+ EE +E+E EE EEEE E EKEE EE + K E
Sbjct: 108 EECSAQQGLPVEEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKME 167
Query: 1934 SVKLQ 1938
K++
Sbjct: 168 EEKVE 172
Score = 35.0 bits (79), Expect = 1.9
Identities = 27/76 (35%), Positives = 35/76 (46%), Gaps = 6/76 (7%)
Query: 4479 GVDGVEEELPPEPEPEPEPELEPEKA-DAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEA 4537
G+ EEE+ E E E E E EK D E EKEE E E +K+ K EE
Sbjct: 115 GLPVEEEEVEEEEEEVEEEEKEEEKEEDEEEEEKEEEKEEDEEEEEKEGKKMEEEKVEEE 174
Query: 4538 GGEFWGELEVQRVKFL 4553
+ E+QR ++L
Sbjct: 175 I-----DTEIQRTQYL 185
>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
Length = 587
Score = 62.4 bits (150), Expect = 1e-08
Identities = 33/74 (44%), Positives = 50/74 (67%), Gaps = 6/74 (8%)
Query: 1851 MGIFGDEDVKQIL------KMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKE 1904
+G G E ++++L K++ E+EEEE+E EE EEE EEE+EEDEEE +E+E
Sbjct: 333 LGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEE 392
Query: 1905 DEEKEEEEAAEGEK 1918
+EE+E ++ +GEK
Sbjct: 393 EEEEEPQQRGQGEK 406
Score = 58.5 bits (140), Expect = 2e-07
Identities = 29/71 (40%), Positives = 48/71 (67%), Gaps = 4/71 (5%)
Query: 1855 GDEDVKQILKMIE----PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
G+E +Q+ +++E +V ++EDEEEE E E+EEE+ E+EEE +E+E+EE+EE
Sbjct: 334 GEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEE 393
Query: 1911 EEAAEGEKEEG 1921
EE ++ +G
Sbjct: 394 EEEEPQQRGQG 404
Score = 45.8 bits (107), Expect = 0.001
Identities = 25/62 (40%), Positives = 36/62 (58%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
DED ++ + E E EEEEEEDEEEE EEE+EEE+E + ++ ++ +
Sbjct: 360 DEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNT 419
Query: 1916 GE 1917
GE
Sbjct: 420 GE 421
>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
Length = 675
Score = 62.4 bits (150), Expect = 1e-08
Identities = 63/249 (25%), Positives = 111/249 (44%), Gaps = 17/249 (6%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
D+D ++ K I E T + E + EE +++ EEEK EEE + E E++E E+ +
Sbjct: 354 DDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQ 413
Query: 1916 --GEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQ 1973
GE+EE E L + E +KL+ ++ + L+ + E + +E+ + K +
Sbjct: 414 EMGEEEEENETFGLSREYEELIKLKRSGSIQ---AKNLKSKFEKIGQLSEKEIQKKIEEE 470
Query: 1974 RSRYGLLIKAFSMTAAET--------ARRTREFRSPPQEQINMLLQFKD---GTDEEDCP 2022
R+R + AE R R+ +P ++NM +F+ +EE+
Sbjct: 471 RARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQR 530
Query: 2023 LPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEE 2082
EE + + F Q + +Q EEEE EE + + E+ R +KP +
Sbjct: 531 RIEEQKLLRMQFEQREI-DAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLK 589
Query: 2083 ERSAEESKP 2091
S +S+P
Sbjct: 590 NTSVVDSEP 598
Score = 41.2 bits (95), Expect = 0.026
Identities = 59/243 (24%), Positives = 104/243 (42%), Gaps = 37/243 (15%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLP 1932
+E ++ EEE + EEEK EE Q ++E+ ++ A + +G G L++
Sbjct: 259 QENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTA---KIFKGYRPGKLKLSF- 314
Query: 1933 ESVKLQMCHLLEYFCDQELQHRV-ESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAET 1991
E ++ Q + ++E + R+ E AFAE +R +++ S +T
Sbjct: 315 EEMERQRREDEKRKAEEEARRRIEEEKKAFAE-----------ARRNMVVDDDSPEMYKT 363
Query: 1992 ARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEE 2051
++EF +P + +IN K +EE EE R+ L+ + ++ EEE
Sbjct: 364 I--SQEFLTPGKLEINFEELLKQKMEEEKRRTEEE-RKHKLEMEKQEFEQLRQEMGEEEE 420
Query: 2052 EPE--------EE--------TTLGSRLMSLLEKVRLVKKKE--EKPEEERSAEESKPRS 2093
E E EE + L S EK+ + +KE +K EEER+ +
Sbjct: 421 ENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLE 480
Query: 2094 LQE 2096
++E
Sbjct: 481 IKE 483
Score = 33.5 bits (75), Expect = 5.5
Identities = 60/284 (21%), Positives = 109/284 (38%), Gaps = 22/284 (7%)
Query: 1828 DPVGGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEE 1887
+ V VE +VP KL T V G F + + K + E + + E+E + E+
Sbjct: 84 EDVSSKVEKAYVP--KLTGT--VKGRFAEME-----KQRQEE---QRKRTEEERKRRIEQ 131
Query: 1888 DEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFC 1947
D EK + + E A+ E E E EEG ++ LL +P + + F
Sbjct: 132 DMLEKRKIQRELAKRAEQIEDINNTGTESASEEG-DDSLLITVVPVKSYKTSGKMKKNFE 190
Query: 1948 DQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQIN 2007
D E + + + E + + + S + M + +E SP + ++
Sbjct: 191 DLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLT 250
Query: 2008 MLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTL------GS 2061
+ + EE R+ L+ + Q+ E+EE ++ + G
Sbjct: 251 FEELERQRQENRKKQAEEEARK-RLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGK 309
Query: 2062 RLMSL--LEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMVV 2103
+S +E+ R +K + EE R E + ++ E +MVV
Sbjct: 310 LKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVV 353
>gi|189409130 zinc finger E-box binding homeobox 1 isoform a [Homo
sapiens]
Length = 1108
Score = 60.5 bits (145), Expect = 4e-08
Identities = 37/81 (45%), Positives = 49/81 (60%), Gaps = 1/81 (1%)
Query: 1855 GDEDVKQILKMIEPEVFT-EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEA 1913
GD D ++ L E E EEEEE+ E EE +EE E EK + +EE +E+E+ E+EE E
Sbjct: 1004 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE 1063
Query: 1914 AEGEKEEGLEEGLLQMKLPES 1934
AE E EE EGL++ ES
Sbjct: 1064 AENEGEEAKTEGLMKDDRAES 1084
Score = 42.7 bits (99), Expect = 0.009
Identities = 22/63 (34%), Positives = 39/63 (61%)
Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKL 1931
++ + +E E EE+++ EKEE+EE+ E+ EEKE E+ E+EE EE + + ++
Sbjct: 1002 SQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEV 1061
Query: 1932 PES 1934
E+
Sbjct: 1062 EEA 1064
Score = 42.4 bits (98), Expect = 0.012
Identities = 23/62 (37%), Positives = 36/62 (58%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLP 1932
EEEEEE+EE E EE +E E E +E +T +D+ E + ++ G+K E + + K
Sbjct: 1047 EEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTN 1106
Query: 1933 ES 1934
E+
Sbjct: 1107 EA 1108
Score = 36.2 bits (82), Expect = 0.85
Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 4/57 (7%)
Query: 1872 TEEEEEEDE----EEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
TE+EE E E G + + DE E+ +EDE+ E+EE E ++ E L+E
Sbjct: 980 TEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQE 1036
Score = 34.3 bits (77), Expect = 3.2
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 5/62 (8%)
Query: 1868 PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEE-----EAAEGEKEEGL 1922
PE+ + E + DE E EE+ EKE+EE+++E E E EK +G
Sbjct: 987 PEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGD 1046
Query: 1923 EE 1924
EE
Sbjct: 1047 EE 1048
>gi|189409128 zinc finger E-box binding homeobox 1 isoform b [Homo
sapiens]
Length = 1124
Score = 60.5 bits (145), Expect = 4e-08
Identities = 37/81 (45%), Positives = 49/81 (60%), Gaps = 1/81 (1%)
Query: 1855 GDEDVKQILKMIEPEVFT-EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEA 1913
GD D ++ L E E EEEEE+ E EE +EE E EK + +EE +E+E+ E+EE E
Sbjct: 1020 GDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEVEE 1079
Query: 1914 AEGEKEEGLEEGLLQMKLPES 1934
AE E EE EGL++ ES
Sbjct: 1080 AENEGEEAKTEGLMKDDRAES 1100
Score = 42.7 bits (99), Expect = 0.009
Identities = 22/63 (34%), Positives = 39/63 (61%)
Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKL 1931
++ + +E E EE+++ EKEE+EE+ E+ EEKE E+ E+EE EE + + ++
Sbjct: 1018 SQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGDEEEEEEEEEVEEEEV 1077
Query: 1932 PES 1934
E+
Sbjct: 1078 EEA 1080
Score = 42.4 bits (98), Expect = 0.012
Identities = 23/62 (37%), Positives = 36/62 (58%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLP 1932
EEEEEE+EE E EE +E E E +E +T +D+ E + ++ G+K E + + K
Sbjct: 1063 EEEEEEEEEVEEEEVEEAENEGEEAKTEGLMKDDRAESQASSLGQKVGESSEQVSEEKTN 1122
Query: 1933 ES 1934
E+
Sbjct: 1123 EA 1124
Score = 36.2 bits (82), Expect = 0.85
Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 4/57 (7%)
Query: 1872 TEEEEEEDE----EEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
TE+EE E E G + + DE E+ +EDE+ E+EE E ++ E L+E
Sbjct: 996 TEQEEAGPEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQE 1052
Score = 34.3 bits (77), Expect = 3.2
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 5/62 (8%)
Query: 1868 PEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEE-----EAAEGEKEEGL 1922
PE+ + E + DE E EE+ EKE+EE+++E E E EK +G
Sbjct: 1003 PEILSNEHVGARASPSQGDSDERESLTREEDEDSEKEEEEEDKEMEELQEEKECEKPQGD 1062
Query: 1923 EE 1924
EE
Sbjct: 1063 EE 1064
>gi|22749303 hypothetical protein LOC196477 [Homo sapiens]
Length = 406
Score = 60.5 bits (145), Expect = 4e-08
Identities = 36/69 (52%), Positives = 45/69 (65%), Gaps = 2/69 (2%)
Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDE--EETAQEKEDEEKEEEEAAEGEKEEGLEEGL 1926
E EEEE EDEEEE E+E+EEE EE E EE +E E+EE EEEE E E+ EE
Sbjct: 299 EASEEEEEVEDEEEEVEDEEEEEVEEAEYVEEGEEELEEEELEEEEEVLEENEQRGEEFH 358
Query: 1927 LQMKLPESV 1935
L +++P S+
Sbjct: 359 LPLEMPLSI 367
Score = 54.7 bits (130), Expect = 2e-06
Identities = 61/201 (30%), Positives = 86/201 (42%), Gaps = 28/201 (13%)
Query: 1748 PPGRSTENG--------HPRHGLPG---VGVTTSLRP--------PHHFSPPCFVAALPA 1788
PPGR G HPRH P V+T RP P +PP +
Sbjct: 136 PPGRKKRWGRRGRGLRHHPRHSYPRSPPADVSTLPRPVKLYEWREPGMRAPPNTTQFIMN 195
Query: 1789 AGAAEAPARLSPAIPLEALRDKALRMLGEA--VRDGGQHARDPVGGSVEFQFVP--VLKL 1844
+ + EALR + + GEA R G A P GGS E + +
Sbjct: 196 QIYEDMRQQEKVERQQEALRAQKATVSGEASPARSSGNDA--PPGGSKETWGLQETLYGF 253
Query: 1845 VSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKE 1904
V + E+ + + ++ E EEE++ D+EEE ++E + KE EEE E E
Sbjct: 254 VQNPSLAFSPNPEENQSLAPLLVEE---EEEKKNDDEEEYDQEVCDAKEASEEEEEVEDE 310
Query: 1905 DEEKEEEEAAEGEKEEGLEEG 1925
+EE E+EE E E+ E +EEG
Sbjct: 311 EEEVEDEEEEEVEEAEYVEEG 331
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 59.7 bits (143), Expect = 7e-08
Identities = 49/171 (28%), Positives = 84/171 (49%), Gaps = 6/171 (3%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
+E+ ++ + E E EEEEE EEEEGEE+ E++EE++++ +EK+ EE +E+E
Sbjct: 2247 EEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVF 2306
Query: 1916 GEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRS 1975
EKEE + E + E + + C L E ++ + E E+ L+ +R
Sbjct: 2307 EEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERV 2366
Query: 1976 RYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEE 2026
L I A R +SP ++ ++ L+ K+ T P+PE+
Sbjct: 2367 ---LSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEMKEKT---PVPVPEK 2411
Score = 45.8 bits (107), Expect = 0.001
Identities = 36/99 (36%), Positives = 51/99 (51%), Gaps = 7/99 (7%)
Query: 1831 GGSVEFQFVPVLKLVSTLLVMGIFGDEDVKQILKMIEP----EVFTEEEEEE-DEEEEGE 1885
GG E + +P LK GD+ ++ ++ E F+EE E DE E+ E
Sbjct: 2182 GGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQE 2241
Query: 1886 EEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
EE+EE EEE +E+E+EE EEE E+EEG E+
Sbjct: 2242 SLSSEEEEEREEE--EEREEEEVREEEEERKEEEEGEEK 2278
Score = 42.7 bits (99), Expect = 0.009
Identities = 66/279 (23%), Positives = 118/279 (42%), Gaps = 60/279 (21%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEET----------AQEKEDEE-----KEEE 1911
E EV EEE + EE+ ++ EE++ EE A++K +E +EEE
Sbjct: 1541 EEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEE 1600
Query: 1912 EAAEGEKEEGLEEGLL---QMKLPESVKLQMCHLLEYFCDQE--LQHRVESLAAFAERYV 1966
+ A+ E++ EE L +K+ + + +M F +E L R E L+ AE+
Sbjct: 1601 KLAQEERQLAQEERKLAQAYVKITQDDR-EMAQAEGKFAQKEETLAQRGEKLSQEAEKLA 1659
Query: 1967 DKLQANQRSRYGLLIKAFSMTAAETAR------RTREFRSPPQEQINMLLQFKDGTDEED 2020
K + L K + A E + + E ++ +++ L Q + D ++
Sbjct: 1660 QKRKK--------LAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQE 1711
Query: 2021 CPLPEEIRQDLLDFHQDLLAHCGIQLD-------------GEEEE---------PEEETT 2058
L +E+ + L++ + L+ +L+ EEEE EEET
Sbjct: 1712 KELAQELEE--LEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETK 1769
Query: 2059 LGSRLMSLL-EKVRLVKKKEEKPEEERSAEESKPRSLQE 2096
L L+ EK +L + KE+ PEEE + + +++
Sbjct: 1770 LAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEK 1808
Score = 38.1 bits (87), Expect = 0.22
Identities = 35/150 (23%), Positives = 66/150 (44%)
Query: 3665 EDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMA 3724
E+ E+ + ++ + E+EE EE+ EK+ + + + + EK ++ E+ +
Sbjct: 2254 EEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIM 2313
Query: 3725 YADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQMISA 3784
+ EE E+ EEEV+ E + EKQ L +Q R RG ++ +
Sbjct: 2314 SEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGV 2373
Query: 3785 CKGETGAMVSSTLKLGISILNGGNAEVQQK 3814
G+ A+ LK + L E+++K
Sbjct: 2374 PHGKGRAIRLGVLKSPLKKLMSTALEMKEK 2403
Score = 36.6 bits (83), Expect = 0.65
Identities = 64/278 (23%), Positives = 115/278 (41%), Gaps = 49/278 (17%)
Query: 1856 DEDVKQILKMIEPEVFTEEE----EEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEE 1911
D K++ + +E + EE EEE +EEG+ +E++K +EEE + ++ EEE
Sbjct: 1708 DWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEE 1767
Query: 1912 EAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQA 1971
E EE L+Q K E LA E+ ++ +
Sbjct: 1768 TKLAQE-----EELLIQEK-------------------------EKLAQHKEKMPEEEER 1797
Query: 1972 NQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQIN-MLLQFKDGTDEEDCPLPEE---- 2026
R R L+ K + +R R S + N M+L K +E L +E
Sbjct: 1798 LGRKREQLIEKKMKL----AQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKL 1853
Query: 2027 -IRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLL--EKVRLVKKKEEKPEEE 2083
R++ L ++++ L H QL + + + +++ L EK ++KKKE+ E E
Sbjct: 1854 AQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETE 1913
Query: 2084 R---SAEESKPRSLQELVSHMVVRWAQEDFVQSPELVR 2118
+ E+S + ++L + ++ VQ + +R
Sbjct: 1914 KKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLR 1951
Score = 35.0 bits (79), Expect = 1.9
Identities = 48/224 (21%), Positives = 98/224 (43%), Gaps = 22/224 (9%)
Query: 1864 KMIEPEVFTEEEEEEDEEEEGEE--EDEEEKEEDEEETAQEKEDEEKEEEEAAEGEK-EE 1920
+MI E EEE + + E +DEEE +EEE + ++ +EA G+K +E
Sbjct: 2152 RMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKE 2211
Query: 1921 GLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLL 1980
+ +++ E +M LL+ EL+ + ESL++ E ++ + +
Sbjct: 2212 KFSSQVDEVESEEHFSEEMESLLD-----ELE-KQESLSSEEEEEREEEEEREEEE---- 2261
Query: 1981 IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLA 2040
E +E ++Q+ + K +E + ++++ + +++++
Sbjct: 2262 -------VREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMS 2314
Query: 2041 HCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEER 2084
+ +EEE EE +L + EK L K+K+ K +E+R
Sbjct: 2315 EEETESLSDEEEEEESCSLEEEVDR--EKEILKKEKQFKLQEQR 2356
>gi|4508005 tripartite motif-containing 26 [Homo sapiens]
Length = 539
Score = 59.3 bits (142), Expect = 9e-08
Identities = 31/62 (50%), Positives = 41/62 (66%), Gaps = 12/62 (19%)
Query: 1866 IEPEVFTEEEEEEDEEEEGEEEDEEEK------------EEDEEETAQEKEDEEKEEEEA 1913
+E E ++E+EEE DEEEEGEEE+EEE+ +EDEE E+E+EE+EEEE
Sbjct: 374 VEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESLGDEEEEEEEEEEEV 433
Query: 1914 AE 1915
E
Sbjct: 434 LE 435
Score = 48.9 bits (115), Expect = 1e-04
Identities = 30/65 (46%), Positives = 39/65 (60%), Gaps = 10/65 (15%)
Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETA--------QEKEDEEK--EEEEAAEGEK 1918
EV E E ++EEEG+EE+E E+EE+EEE + EDEE +EEE E E+
Sbjct: 371 EVEVEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESLGDEEEEEEEEE 430
Query: 1919 EEGLE 1923
EE LE
Sbjct: 431 EEVLE 435
Score = 41.6 bits (96), Expect = 0.020
Identities = 24/62 (38%), Positives = 37/62 (59%), Gaps = 6/62 (9%)
Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEK------EDEEKEEEEAAEGEKEEGL 1922
+V+ E E E + E EEE +EE+E +EEE +E +D E +E+E + G++EE
Sbjct: 367 KVYWEVEVEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESLGDEEEEE 426
Query: 1923 EE 1924
EE
Sbjct: 427 EE 428
>gi|21735569 claspin [Homo sapiens]
Length = 1339
Score = 58.5 bits (140), Expect = 2e-07
Identities = 29/58 (50%), Positives = 39/58 (67%)
Query: 1862 ILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKE 1919
+ K+ + F EEEEEE+E + EED EEK E EE+ + +E+EEKEEEE EG +E
Sbjct: 619 LFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQE 676
Score = 48.1 bits (113), Expect = 2e-04
Identities = 28/54 (51%), Positives = 37/54 (68%), Gaps = 4/54 (7%)
Query: 1875 EEEEDEEEEGEEEDE--EEKEEDEEETA--QEKEDEEKEEEEAAEGEKEEGLEE 1924
+ E+ EEE EEE+E +E EED EE +EKE+E +EEEE E E+EEG +E
Sbjct: 623 DNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQE 676
Score = 45.1 bits (105), Expect = 0.002
Identities = 33/102 (32%), Positives = 54/102 (52%), Gaps = 14/102 (13%)
Query: 1854 FGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQ------------ 1901
F +E+ ++ E E EE+ E++E+EE EE+EE++EE+EEE Q
Sbjct: 628 FEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEI 687
Query: 1902 EKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLL 1943
E +DE++ ++E +G E G G L +P+S+ LL
Sbjct: 688 ETKDEKEMDKENNDGSSEIGKAVGFL--SVPKSLSSDSTLLL 727
Score = 39.3 bits (90), Expect = 0.10
Identities = 25/62 (40%), Positives = 33/62 (53%), Gaps = 8/62 (12%)
Query: 1871 FTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKED--------EEKEEEEAAEGEKEEGL 1922
F E ++ + + E+ EE+EE+EEE E E+ EEKEEE E EKEE
Sbjct: 610 FEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEE 669
Query: 1923 EE 1924
EE
Sbjct: 670 EE 671
Score = 36.2 bits (82), Expect = 0.85
Identities = 51/227 (22%), Positives = 90/227 (39%), Gaps = 14/227 (6%)
Query: 1889 EEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLE---EGLLQMKLPESVKLQMCHLLEY 1945
E E ++ EET ++ E+ E++ + +A G E+ + L Q+ + S+K ++ +
Sbjct: 457 EGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDS 516
Query: 1946 FCDQELQHRVESLAAFAERY------VDKLQANQRSRYGLLIKAFSMTAAETARRTREFR 1999
F E + E L A +R+ K +A Q +++K E +
Sbjct: 517 FVILEPETNRE-LEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPV 575
Query: 2000 SPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGE----EEEPEE 2055
+ ++++ K G + + L F + +LD E EEE EE
Sbjct: 576 TLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEE 635
Query: 2056 ETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMV 2102
E EKV +K+EE EEE EE + QE ++
Sbjct: 636 EEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLL 682
Score = 34.7 bits (78), Expect = 2.5
Identities = 19/72 (26%), Positives = 36/72 (50%), Gaps = 10/72 (13%)
Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGE----------EEDEEEKEEDEEETAQEKEDE 1906
+ +++ L + T++EEE++EEE G+ + DE+E + + A E ++
Sbjct: 972 DPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHED 1031
Query: 1907 EKEEEEAAEGEK 1918
+ EEE EK
Sbjct: 1032 DDEEELLKRSEK 1043
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 58.5 bits (140), Expect = 2e-07
Identities = 63/257 (24%), Positives = 115/257 (44%), Gaps = 27/257 (10%)
Query: 1866 IEPEVFTEEEEEE--------DEEEEGEEE----DEEEKEEDEEETAQE--KEDEEKEEE 1911
++ E TE E+E D+EEE E +EEE+ E +E Q+ +E EE+ E+
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 1912 EAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQA 1971
E+EE L++ +++ + ++ + E +E + R+E ER +L+
Sbjct: 518 RLKRQEEEERLQQ---RLRSEQQLRREQEERREQLLKREEEKRLEQ-----ERREQRLKR 569
Query: 1972 NQRSRYGLLIKAFSMTAAETARRTREFRSP---PQEQINMLLQFKDGTDEEDCPLPEEIR 2028
Q R L+K + +R +E R +E++ L Q + PEE R
Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629
Query: 2029 QDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEE 2088
+ L ++ QL E++E E+ LE+ RL ++ EE+ E+ AEE
Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ-RLKREHEEERREQELAEE 688
Query: 2089 SKPRSLQELVSHMVVRW 2105
+ ++ +E + + +W
Sbjct: 689 EQEQA-RERIKSRIPKW 704
Score = 55.1 bits (131), Expect = 2e-06
Identities = 56/246 (22%), Positives = 106/246 (43%), Gaps = 21/246 (8%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLP 1932
EEE E +EE E+++ E++E+ E +E EE+ E++ ++EE E+ L + +
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 1933 ESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETA 1992
E + Q+ + +Q+L+ + R +L+ Q+ R +
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-----------REQQL 419
Query: 1993 RRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAH------CGIQL 2046
RR ++ R QE+ + + E+ +E R+D L ++ H ++
Sbjct: 420 RREQQLRR-EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478
Query: 2047 DGEEEEPEEETTLGS---RLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMVV 2103
D EEE E L R + +L +++EE+ E+ +E + R Q L S +
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 2104 RWAQED 2109
R QE+
Sbjct: 539 RREQEE 544
Score = 49.3 bits (116), Expect = 1e-04
Identities = 55/239 (23%), Positives = 106/239 (44%), Gaps = 14/239 (5%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE--KEEEEAAEGEKEEGLEE 1924
EP ++ +E E E E E++ EK+E E+ +++ DEE ++ +E E E+ EE
Sbjct: 132 EPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE 191
Query: 1925 GLLQMK------LPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYG 1978
L K P+ +L+ LLE + + + + ++ + R R
Sbjct: 192 QLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRET 251
Query: 1979 LLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDL 2038
+L K E +R RE + +EQ+ L + + + ++ EE +Q L Q L
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQE-EEEQLRKLERQELRRERQE----EEQQQQRLRREQQL 306
Query: 2039 LAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQEL 2097
+ ++EE E+ + E+ +L +++EE+ E++ E+ + R Q+L
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQ-QLRREQEERREQQLRREQEEERREQQL 364
Score = 48.5 bits (114), Expect = 2e-04
Identities = 61/263 (23%), Positives = 116/263 (44%), Gaps = 37/263 (14%)
Query: 1853 IFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEE 1912
+ G+E K+ + E + EEE +++EE+ EE E+ + ++ E ++K++ ++EEE+
Sbjct: 973 LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032
Query: 1913 AAEGEKEE-GLEEGLLQMKLPESVKLQMCHLL--------------EYFCDQELQHRVES 1957
E+E+ L+E Q + E ++ + LL +Y ++ELQ E
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092
Query: 1958 LAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTD 2017
L +K + +R R + + R RE R ++++ + ++
Sbjct: 1093 L---LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR--RQELERQYREEEEVQ 1147
Query: 2018 EEDCPL----PEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLV 2073
+E+ L PE+ R+ L+ Q EEE +EE L L EK R
Sbjct: 1148 QEEEQLLREEPEKRRRQELE----------RQYREEEELQQEEEQL---LREEQEKRRQE 1194
Query: 2074 KKKEEKPEEERSAEESKPRSLQE 2096
++++ + EEE ++ K R E
Sbjct: 1195 RERQYREEEELQRQKRKQRYRDE 1217
Score = 47.4 bits (111), Expect = 4e-04
Identities = 54/240 (22%), Positives = 97/240 (40%), Gaps = 6/240 (2%)
Query: 1871 FTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMK 1930
+ EEE+ + EEE+ E+ E++ E E K+ + +++EE GE+ E + K
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 1931 LPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAE 1990
E +LQ ++E + R E + +Y K + Q L + E
Sbjct: 990 YREEEELQQEEEQLLREEREKRRRQE----WERQYRKKDELQQEEEQLLREEREKRRLQE 1045
Query: 1991 TARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEE 2050
R+ RE QE+ +L + ++ ++ ++L + LL + +E
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105
Query: 2051 EEPE--EETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMVVRWAQE 2108
E + EE L LL + R ++++E + R EE + Q L R QE
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQE 1165
Score = 47.0 bits (110), Expect = 5e-04
Identities = 61/288 (21%), Positives = 120/288 (41%), Gaps = 34/288 (11%)
Query: 1856 DEDVKQILKMIEPEVFTEEEE-------EEDEEEEGEEEDEEEKEEDEEETAQEKEDEEK 1908
+E ++Q LK E E +EE EE EEE ++ + E++E+ + +E +E+
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654
Query: 1909 EEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDK 1968
E+ E+EE LE+ L + E + ++ ++E + E + + ++ +
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERREQEL-------AEEEQEQARERIKSRIPKWQWQ 707
Query: 1969 LQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIR 2028
L++ +R K +S + +R R+ + + + LQ+++ EE R
Sbjct: 708 LESEADARQS---KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764
Query: 2029 QDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEER---S 2085
+D Q EE+ L +R ++ R ++ +E + E+R
Sbjct: 765 RDFT-----------WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 2086 AEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGE 2133
EE + R Q +++ +E+ Q RA L + DGL E
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEE-EQLQRRERA--QQLQEEEDGLQE 858
Score = 47.0 bits (110), Expect = 5e-04
Identities = 58/265 (21%), Positives = 115/265 (43%), Gaps = 28/265 (10%)
Query: 1860 KQILKMIEPEVFTEEEEEED-EEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEK 1918
+Q+L+ E E+ EE E+ +E+E + +EE+ +++EE+ +E+ ++ + +E + K
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962
Query: 1919 EEGLEEGLLQM--KLPESVKLQMCHLLEYFCDQELQHRVESLAA----------FAERYV 1966
++ L++ Q+ + PE + Q +Y ++ELQ E L + +Y
Sbjct: 963 DKKLQQKEEQLLGEEPEKRRRQEREK-KYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021
Query: 1967 DKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEE 2026
K + Q L + E R+ RE QE+ +L + ++ ++
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 2027 IRQDLLDFHQDLLAHCGIQLDGEEEEPE--EETTLGSRLMSLLEKVRLVKKKEE------ 2078
++L + LL + +E E + EE L LL + R ++++E
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 2079 ------KPEEERSAEESKPRSLQEL 2097
+ EE+ EE + R QEL
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQEL 1166
Score = 45.4 bits (106), Expect = 0.001
Identities = 57/257 (22%), Positives = 114/257 (44%), Gaps = 22/257 (8%)
Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPE 1933
EEE+ + EE+ E + + K ++E++ +E+ +E++ +E +E EE LLQ + E
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE---EEQLLQER--E 1349
Query: 1934 SVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETAR 1993
L+ F ++EL+H+ + E +L+ +R R L + + E +
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEE--QRLRRQERER-KFLKEEQQLRCQEREQ 1406
Query: 1994 RTREFRS----PPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGE 2049
+ R+ R ++Q++ + + +EE +E + L+ Q L + E
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Query: 2050 E----EEPEEETTLGSRLMSLLEKVRLVKKKEE----KPEEERSAEESKPRSLQELVSHM 2101
E E E++ R LE+ + ++++E + +E RS E + +E H
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526
Query: 2102 VVRWAQEDFVQSPELVR 2118
R Q F+Q + +R
Sbjct: 1527 QQR--QRKFLQEEQQLR 1541
Score = 44.7 bits (104), Expect = 0.002
Identities = 58/275 (21%), Positives = 108/275 (39%), Gaps = 42/275 (15%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE-KEEEEAA 1914
+E +Q+LK E E +++ +++E E+ + E+EE+ E ++E EE + E+E A
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686
Query: 1915 EGEKEEGLEE----------------GLLQMKLPESVKLQMCHLLEYFCDQELQHRVESL 1958
E E+E+ E Q K+ + Q +++ + R L
Sbjct: 687 EEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746
Query: 1959 AAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDE 2018
E + Q + R + + +E R+ R P +EQ L+ ++
Sbjct: 747 QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806
Query: 2019 EDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEE 2078
E LPEE ++ Q + E E+E + LE+ ++++E
Sbjct: 807 EQRFLPEEEEKE--------------QRRRQRREREKE-------LQFLEEEEQLQRRER 845
Query: 2079 ----KPEEERSAEESKPRSLQELVSHMVVRWAQED 2109
+ EE+ E+ + R QE RW E+
Sbjct: 846 AQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE 880
Score = 44.3 bits (103), Expect = 0.003
Identities = 56/258 (21%), Positives = 109/258 (42%), Gaps = 27/258 (10%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEE-----EEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
+E+ Q K E E F +EE+ E +G EE ++++ E ++ QE+E++E +
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248
Query: 1911 EEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQ 1970
E ++EE L+E Q + +ELQ E L + + + +
Sbjct: 249 RETVLRKEEEKLQEEEPQRQ------------------RELQEEEEQLRKLERQELRRER 290
Query: 1971 ANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQD 2030
+ + L + + + R RE + +EQ Q ++ +++ EE R+
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEER-REQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 2031 LLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESK 2090
L Q+ QL E+EE E L R L + + ++++++ E++ E +
Sbjct: 350 QLRREQE-EERREQQLRREQEEERREQQL--RREQQLRREQQLRREQQLRREQQLRREQQ 406
Query: 2091 PRSLQELVSHMVVRWAQE 2108
R Q+L +R Q+
Sbjct: 407 LRREQQLRREQQLRREQQ 424
Score = 43.5 bits (101), Expect = 0.005
Identities = 55/231 (23%), Positives = 99/231 (42%), Gaps = 30/231 (12%)
Query: 1863 LKMIEPEVFTEEEEEEDEEE-EGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
L+ E ++ EE E+ +E E + +EEE +++EE+ +E+ ++ + +E + +EE
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175
Query: 1922 LEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLI 1981
L++ Q+ E K + +Y ++ELQ + +RY D+ +QRS +
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK-----QRYRDE---DQRSD----L 1223
Query: 1982 KAFSMTAAETARRTREF--RSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLL 2039
K E A R + + EQ L ED L + Q QDL
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQL---------EDSQLRDRQSQ------QDLQ 1268
Query: 2040 AHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESK 2090
G Q + + E+ R E++ ++KE K + +S EE +
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319
Score = 43.1 bits (100), Expect = 0.007
Identities = 56/244 (22%), Positives = 105/244 (43%), Gaps = 20/244 (8%)
Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
G E+ +Q + + VF EEEE+E + E EEEK ++EE Q + EE+E+
Sbjct: 222 GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281
Query: 1915 EGE--KEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQ-ELQHRVESLAAFAERYVDKLQA 1971
E + + E EE Q +L +L+ E Q E + + E ER +L+
Sbjct: 282 ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341
Query: 1972 NQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDL 2031
Q R ++ E RR ++ R +E+ E+ +++R++
Sbjct: 342 EQEERREQQLR----REQEEERREQQLRREQEEE----------RREQQLRREQQLRRE- 386
Query: 2032 LDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKP 2091
++ QL E++ E+ R L + +L +++EE+ E++ +E +
Sbjct: 387 QQLRREQQLRREQQLRREQQLRREQQL--RREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 2092 RSLQ 2095
+ L+
Sbjct: 445 QRLK 448
Score = 42.4 bits (98), Expect = 0.012
Identities = 69/296 (23%), Positives = 119/296 (40%), Gaps = 54/296 (18%)
Query: 1857 EDVKQILKMIEPEVFTEEE----EEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEE 1912
++ +Q L+ F E+E E E+++ +E D + EE+ + QE+E + + + +
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRD 1666
Query: 1913 AAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQAN 1972
E+E+ L+EG E +L+ F ++E Q R + ER LQ
Sbjct: 1667 RKFREEEQLLQEG-------EEQQLRRQERDRKFREEEQQLRRQ------ERERKFLQEE 1713
Query: 1973 QRSRYGLLIKAF-------SMTAAETARRTREFRS--------PPQEQINMLLQFKDGTD 2017
Q+ R L + F T E RR +R P +E+ + Q +D
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKF 1773
Query: 2018 EEDCPLPEE-IRQDLLDFHQDLLAHCGIQLDGEEEEPE------------EETTLGSRLM 2064
E+ L +E Q L D QL E EE + EE L +L
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL--QLE 1831
Query: 2065 SLLEKVRLVKKKEEKPEEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAM 2120
+++R + ++ + EE+ + +E R QEL W +E+ + E R +
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFATQEKSRREEQEL-------WQEEEQKRRQERERKL 1880
Score = 40.8 bits (94), Expect = 0.034
Identities = 57/236 (24%), Positives = 95/236 (40%), Gaps = 38/236 (16%)
Query: 1875 EEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPES 1934
E++ E++ E EEE+ E + E + ++ ++E+EE + K E E Q + +
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475
Query: 1935 VKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKAFSMTAAETARR 1994
+K DQE + R ER++ KL+ +R + E R
Sbjct: 476 LKR----------DQEEERR--------ERWL-KLEEEERREQQERREQQLRREQEERRE 516
Query: 1995 TREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPE 2054
R R +E++ L+ + E EE R+ LL EEE+
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQ----EERREQLLK--------------REEEKRL 558
Query: 2055 EETTLGSRLMSLLEKVR-LVKKKEEKPEEERSAEESKPRSLQELVSHMVVRWAQED 2109
E+ RL E+ R + K+EE+ ++R E + R Q L V R QE+
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEE 614
Score = 40.8 bits (94), Expect = 0.034
Identities = 28/98 (28%), Positives = 50/98 (51%), Gaps = 13/98 (13%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDE----EETAQEKEDEEKEEEEAAEGEKEEG- 1921
E + T+E+ +E+E +EE+++ ++E E EE + ++ EE+ + E + +EG
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
Query: 1922 -----LEEGLLQMKLPESVKLQMCHLLEYFCDQELQHR 1954
LE G Q SV ++ L EY +Q Q+R
Sbjct: 1908 GHGRLLEPGTHQF---ASVPVRSSPLYEYIQEQRSQYR 1942
Score = 38.5 bits (88), Expect = 0.17
Identities = 54/257 (21%), Positives = 109/257 (42%), Gaps = 10/257 (3%)
Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
G+E ++ ++ + + +EE + +E +E +E EE++ ++ + E EE +EE
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE-- 208
Query: 1915 EGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQR 1974
+ + E LE L+ K E + Q + +E + + +KLQ +
Sbjct: 209 QLRRRELLE---LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265
Query: 1975 SRYGLL---IKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDL 2031
R L + + RR R+ Q+++ Q + +EE EE R++
Sbjct: 266 QRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE-RREQ 324
Query: 2032 LDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKP 2091
+ + QL E+EE E+ + E+ +L +++EE+ E++ E +
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQ-QLRREQEEERREQQLRREQQL 383
Query: 2092 RSLQELVSHMVVRWAQE 2108
R Q+L +R Q+
Sbjct: 384 RREQQLRREQQLRREQQ 400
Score = 38.1 bits (87), Expect = 0.22
Identities = 53/256 (20%), Positives = 111/256 (43%), Gaps = 35/256 (13%)
Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE------KEE 1910
E+ +++ + + E E+EE E+ + E+E+ E++ E ++E EE K E
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 1911 EEAAE----GEKEEGLEEGLLQMKLP--ESVKLQMCHLLEYFCDQELQHRVESLAAFAER 1964
EE + E+EE LE+ L + ++ E + + L ++E + ++ ER
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 1965 YVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLP 2024
+L+ Q+ R R R R +E++ L+ + + + L
Sbjct: 643 RQQQLRREQQER----------------REQRLKREEEEERLEQRLKREHEEERREQELA 686
Query: 2025 EEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEER 2084
EE ++ + + + QL+ E + + S++ S K ++++E+ EE+R
Sbjct: 687 EEEQEQARERIKSRIPKWQWQLESEADARQ------SKVYSRPRKQEGQRRRQEQ-EEKR 739
Query: 2085 SAEESKPRSLQELVSH 2100
ES+ + +E +H
Sbjct: 740 RRRESELQWQEEERAH 755
Score = 37.7 bits (86), Expect = 0.29
Identities = 50/244 (20%), Positives = 105/244 (43%), Gaps = 23/244 (9%)
Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEE--KEEDEEETAQEKEDEE--KEEEE 1912
E+ +Q+ + F EEE++ +E + +EE+ +E +E++ +++ D + +EE++
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493
Query: 1913 AAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQAN 1972
E++ E L+ + PE L+ +++ HR + F + +L+
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLE---------EEQQLHRQQRQRKFLQE-EQQLRRQ 1543
Query: 1973 QRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLL 2032
+R + + E R+ RE ++Q++ + + EE +E + +
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQERE-----EQQLSRQERDRKFRLEEQKVRRQEQERKFM 1598
Query: 2033 DFHQDLLAHCGIQLDGEEEE---PEEETTLGSRLMSLLEKVRLVKK-KEEKPEEERSAEE 2088
+ Q L G Q +E + E+E L R L + +K EE+P+ R E
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658
Query: 2089 SKPR 2092
+ R
Sbjct: 1659 QQLR 1662
Score = 37.4 bits (85), Expect = 0.38
Identities = 53/251 (21%), Positives = 97/251 (38%), Gaps = 33/251 (13%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEED-------EEEKEEDEEETAQEKEDEEKEEEEAAEGEKE 1919
E EEEE+E + E + EEE+ + E Q +E+E+ +E+ +
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ 866
Query: 1920 EGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGL 1979
E + + +L E K + H L + LQ ++ + ++LQ +R +
Sbjct: 867 EQRRDQKWRWQLEEERKRRR-HTL--YAKPALQEQLRKEQQLLQEEEEELQREEREK--- 920
Query: 1980 LIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQDLL 2039
E R+ RE QE+ +L + ++ ++ + L + LL
Sbjct: 921 ------RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL 974
Query: 2040 AHCGIQLDGEEEEPE--EETTLGSRLMSLLEKVRLVKKKEE------------KPEEERS 2085
+ +E E + EE L LL + R ++++E + EE+
Sbjct: 975 GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLL 1034
Query: 2086 AEESKPRSLQE 2096
EE + R LQE
Sbjct: 1035 REEREKRRLQE 1045
Score = 37.4 bits (85), Expect = 0.38
Identities = 52/272 (19%), Positives = 112/272 (41%), Gaps = 47/272 (17%)
Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEE--EDEEEKEEDEEETAQEKEDE-------- 1906
E+ +Q+ + F +EE++ +E G++ +D + K +EE+ QE+E++
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578
Query: 1907 ------------EKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHR 1954
+++E + E E++ +EG Q++ K + L +++ HR
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638
Query: 1955 VESLAAFAER--YVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQ-----EQIN 2007
E F E + + + Q+ R+ R R+FR Q E+
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLRHD---------------RDRKFREEEQLLQEGEEQQ 1683
Query: 2008 MLLQFKDGT-DEEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSL 2066
+ Q +D EE+ L + R+ + L ++ EEE + T +L
Sbjct: 1684 LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQ 1743
Query: 2067 LEKVRLVKKKEEKP--EEERSAEESKPRSLQE 2096
+++++++ +P EE++ + + R +E
Sbjct: 1744 ERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Score = 35.8 bits (81), Expect = 1.1
Identities = 39/167 (23%), Positives = 79/167 (47%), Gaps = 18/167 (10%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEE------DEEETAQEK------ 1903
+E K+ + +E + EEE +++EE+ EE E+ ++E +EEE ++K
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYR 1215
Query: 1904 -EDEEKEEEEAAEGEKEEGLEEGLLQMKLPESV---KLQMCHLLEYFCDQELQHRVESLA 1959
ED+ + + E EKE + + + K E+ +L+ L + Q+LQH +
Sbjct: 1216 DEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275
Query: 1960 AFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQI 2006
+R ++ + QR R+ + + A+R R+ +S ++Q+
Sbjct: 1276 E-RDREQERRRWQQRDRHFPEEEQLEREEQKEAKR-RDRKSQEEKQL 1320
Score = 35.4 bits (80), Expect = 1.4
Identities = 53/295 (17%), Positives = 126/295 (42%), Gaps = 37/295 (12%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEG----EEEDEEEKEEDEEETAQEKEDEEKEEE 1911
+ + +Q+ + F EE++ +E+ E+E + ++E +++ QE++ + +E+E
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE 1625
Query: 1912 EAAEGEKEEGLEEGLLQMKL----PESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVD 1967
+ + +E+ L K P+ + + L + D++ + + L E+ +
Sbjct: 1626 QLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685
Query: 1968 KLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEI 2027
+ + +++ R + RR R QE+ + Q + E+ L +E
Sbjct: 1686 RQERDRKFR----------EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET 1735
Query: 2028 RQDLL---DFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKP---- 2080
Q+ L + ++ +L ++ + EE++ + R E+ +L +++EE+
Sbjct: 1736 EQEQLRRQERYRKILEEEQLRPEREEQQLRRQ----ERDRKFREEEQLRQEREEQQLRSQ 1791
Query: 2081 -------EEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQY 2128
EEE+ +E + + L+ RW +E+ +Q E + + RQY
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRW-EEEQLQLEEQEQRLRQERDRQY 1845
Score = 34.7 bits (78), Expect = 2.5
Identities = 52/244 (21%), Positives = 100/244 (40%), Gaps = 17/244 (6%)
Query: 1871 FTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMK 1930
F EEEE+ E ++ EEE E++ + +++ ++++ + E+E L K
Sbjct: 833 FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Query: 1931 --LPESVKLQMCHLLEYFCDQELQHRVESLAAFAER-YVDKLQANQRSRYGLLIKAFSMT 1987
L E ++ + L E + + + R + ER Y ++ Q Q L +
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Query: 1988 AAETARRTREFRSPPQEQINML----------LQFKDGTDEEDCPLPEE--IRQDLLDFH 2035
E R+ R+ + Q++ +L + K +EE+ EE +R++
Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012
Query: 2036 QDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERS--AEESKPRS 2093
+ + D ++E E+ L E+ R +++EE +EE EE + R
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR 1072
Query: 2094 LQEL 2097
QEL
Sbjct: 1073 RQEL 1076
Score = 34.3 bits (77), Expect = 3.2
Identities = 60/278 (21%), Positives = 113/278 (40%), Gaps = 23/278 (8%)
Query: 1857 EDVKQILKMIEPEVFTEEEEE----EDEEEEGEEEDEEEKEEDEEETAQEKEDE--EKEE 1910
E+ +++ + F +EE++ E E++ ++ D + +EE+++ + QE++ + E+E+
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 1911 EEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQ 1970
+ + + + LEE E Q H +Q LQ R E ER L+
Sbjct: 1438 QVRRQERERKFLEE--------EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLE 1489
Query: 1971 ANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQD 2030
Q+ R + F + R+F Q+ Q K +E+ E +Q
Sbjct: 1490 EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549
Query: 2031 LLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESK 2090
D +D QL E EE + R K RL ++K + E+ER E +
Sbjct: 1550 RQD--RDRKFREEEQLRQEREEQQLSRQERDR------KFRLEEQKVRRQEQERKFMEDE 1601
Query: 2091 PRSLQELVSHMVVRWAQEDFVQSPELVRAM-FSLLHRQ 2127
+ ++ + + F + +L++ LHRQ
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ 1639
Score = 32.7 bits (73), Expect = 9.4
Identities = 16/58 (27%), Positives = 33/58 (56%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
E ++ EE+E+ +E + EE+ +E++ +E+++ +EEE+ E+E L E
Sbjct: 1825 EEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882
>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
[Homo sapiens]
Length = 2073
Score = 58.2 bits (139), Expect = 2e-07
Identities = 30/65 (46%), Positives = 44/65 (67%), Gaps = 5/65 (7%)
Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPE 1933
E +E EEE EEEDEEE+EE+EEE E+E+EE+EEE E+EE ++ ++ P+
Sbjct: 1063 ELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEE-----EEEENIQSSPPRLTKPQ 1117
Query: 1934 SVKLQ 1938
SV ++
Sbjct: 1118 SVAIK 1122
Score = 55.1 bits (131), Expect = 2e-06
Identities = 24/42 (57%), Positives = 35/42 (83%)
Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
E+ E EEE+EEE+ EEE+EEE+EE++EE +E+E+EE+EE
Sbjct: 1063 ELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEE 1104
Score = 55.1 bits (131), Expect = 2e-06
Identities = 26/41 (63%), Positives = 32/41 (78%)
Query: 1866 IEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDE 1906
+ E EEEEEEDEEEE EEE+EEE EE+EEE +E+E+E
Sbjct: 1064 LSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEE 1104
Score = 52.4 bits (124), Expect = 1e-05
Identities = 36/105 (34%), Positives = 53/105 (50%), Gaps = 20/105 (19%)
Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEED-------------EEEKEEDEEETAQ 1901
G++ ++K E E EEEEEE+EEEEGEEE+ +EKEE E T +
Sbjct: 1340 GEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEEPEISTEK 1399
Query: 1902 E-------KEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQM 1939
E E+EE+E+EE + E + +E M+ E K ++
Sbjct: 1400 EDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEKEEL 1444
Score = 52.0 bits (123), Expect = 1e-05
Identities = 23/45 (51%), Positives = 36/45 (80%)
Query: 1861 QILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKED 1905
Q+L++ + EEEEE++EEEE EEE+EE++EE+EEE +E+E+
Sbjct: 1060 QLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEE 1104
Score = 43.9 bits (102), Expect = 0.004
Identities = 24/60 (40%), Positives = 36/60 (60%), Gaps = 5/60 (8%)
Query: 1866 IEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDE-----EKEEEEAAEGEKEE 1920
+ P E+ E+D + EEE+EEE+EE+EEE + +E+E EK+ + A EKEE
Sbjct: 1333 VSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQEKEE 1392
Score = 40.0 bits (92), Expect = 0.059
Identities = 23/69 (33%), Positives = 39/69 (56%), Gaps = 4/69 (5%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
+E+VK+ + + P+ EE +E + E+ E++ + +E+EE+EEEE E
Sbjct: 1308 EEEVKETGEALLPQ----EENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEE 1363
Query: 1916 GEKEEGLEE 1924
E+EEG EE
Sbjct: 1364 EEEEEGEEE 1372
Score = 35.0 bits (79), Expect = 1.9
Identities = 29/91 (31%), Positives = 40/91 (43%), Gaps = 36/91 (39%)
Query: 1867 EPEVFTEEEEEEDE----------EEEGEEEDEE-----------------------EKE 1893
+ +V EE++E E EEE +E E EK
Sbjct: 1284 DEQVTVEEQKETSEGKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKP 1343
Query: 1894 EDE---EETAQEKEDEEKEEEEAAEGEKEEG 1921
ED+ E +E+E+EE+EEEE EGE+EEG
Sbjct: 1344 EDDLIKPEEEEEEEEEEEEEEEEEEGEEEEG 1374
Score = 33.9 bits (76), Expect = 4.2
Identities = 24/74 (32%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 4463 AEPPTPEGSPILK-RKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEP 4521
+ P T E +L+ K + EEE E E E E E E E+ + E E+EE P
Sbjct: 1051 SRPVTGERGQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSP 1110
Query: 4522 PKKQAPPSPPPKKE 4535
P+ P S K++
Sbjct: 1111 PRLTKPQSVAIKRK 1124
>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
Length = 709
Score = 58.2 bits (139), Expect = 2e-07
Identities = 29/57 (50%), Positives = 42/57 (73%), Gaps = 1/57 (1%)
Query: 1866 IEPEVFTEEEEEEDEEEEGE-EEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
+E +V +EE EED EE+ E +ED EE+EE+EEE +E+E+EE+E E+ +KEEG
Sbjct: 205 VEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEG 261
Score = 56.6 bits (135), Expect = 6e-07
Identities = 28/54 (51%), Positives = 38/54 (70%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
E E E+ EE++E EE EEDEE E+ EEE +E+E+EE+EEEE E E++E
Sbjct: 201 EEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDE 254
Score = 53.5 bits (127), Expect = 5e-06
Identities = 27/70 (38%), Positives = 46/70 (65%), Gaps = 1/70 (1%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
+EDV++ + +E + +EE +ED EEE EEE+EEE+EE+EEE E+++ +++EE
Sbjct: 206 EEDVEED-EEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDY 264
Query: 1916 GEKEEGLEEG 1925
+ E + G
Sbjct: 265 DTRSEASDSG 274
Score = 52.4 bits (124), Expect = 1e-05
Identities = 29/72 (40%), Positives = 42/72 (58%), Gaps = 2/72 (2%)
Query: 1856 DEDVKQILKMIEP--EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEA 1913
DE+V++ + E E EEEEEE+EEEE EEE+EEE E+DE + +E D + E +
Sbjct: 212 DEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEAS 271
Query: 1914 AEGEKEEGLEEG 1925
G + +G
Sbjct: 272 DSGSESVSFTDG 283
Score = 51.6 bits (122), Expect = 2e-05
Identities = 25/49 (51%), Positives = 35/49 (71%)
Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
TE EEE EE+ E+E+ EE E++EE ++ E+EE+EEEE E E+EE
Sbjct: 198 TENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEE 246
Score = 50.8 bits (120), Expect = 3e-05
Identities = 25/51 (49%), Positives = 35/51 (68%)
Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
E EEE EE+ EE++E E++ +E+E E +EE+EEEE E E+EE EE
Sbjct: 199 ENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEE 249
Score = 49.7 bits (117), Expect = 7e-05
Identities = 27/53 (50%), Positives = 35/53 (66%), Gaps = 1/53 (1%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKE-DEEKEEEEAAEGEKEEGLEE 1924
E+ + EEEG EED EE EE EE+ +++E DE+ EEEE E E+EE EE
Sbjct: 193 EQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEE 245
Score = 47.4 bits (111), Expect = 4e-04
Identities = 23/67 (34%), Positives = 40/67 (59%)
Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG 1916
E+ +++ + E + +E+ EE+EEEE EEE+EEE+EE+E E + + EE + +
Sbjct: 210 EEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSE 269
Query: 1917 EKEEGLE 1923
+ G E
Sbjct: 270 ASDSGSE 276
Score = 42.7 bits (99), Expect = 0.009
Identities = 22/53 (41%), Positives = 30/53 (56%)
Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
T DE+ E +EE EED EE + +ED E++EE +GE+EE EE
Sbjct: 185 TGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEE 237
Score = 42.0 bits (97), Expect = 0.015
Identities = 19/49 (38%), Positives = 31/49 (63%)
Query: 1876 EEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
+E+ E EEE EE E++EE ++ E++E+ +E+ E E+EE EE
Sbjct: 192 DEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEE 240
Score = 39.3 bits (90), Expect = 0.10
Identities = 19/55 (34%), Positives = 30/55 (54%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
E E EEEEEE+EEE ++E ++++E ++ +T E D E +G G
Sbjct: 234 EEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSG 288
Score = 33.9 bits (76), Expect = 4.2
Identities = 22/75 (29%), Positives = 34/75 (45%)
Query: 1851 MGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
+G+ D + + + EV +EE + E DE+ + EE E++ EE EE
Sbjct: 155 IGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEE 214
Query: 1911 EEAAEGEKEEGLEEG 1925
E E EE E+G
Sbjct: 215 VEEDAEEDEEVDEDG 229
>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
Length = 727
Score = 58.2 bits (139), Expect = 2e-07
Identities = 29/57 (50%), Positives = 42/57 (73%), Gaps = 1/57 (1%)
Query: 1866 IEPEVFTEEEEEEDEEEEGE-EEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
+E +V +EE EED EE+ E +ED EE+EE+EEE +E+E+EE+E E+ +KEEG
Sbjct: 205 VEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEG 261
Score = 56.6 bits (135), Expect = 6e-07
Identities = 28/54 (51%), Positives = 38/54 (70%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
E E E+ EE++E EE EEDEE E+ EEE +E+E+EE+EEEE E E++E
Sbjct: 201 EEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDE 254
Score = 53.5 bits (127), Expect = 5e-06
Identities = 27/70 (38%), Positives = 46/70 (65%), Gaps = 1/70 (1%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
+EDV++ + +E + +EE +ED EEE EEE+EEE+EE+EEE E+++ +++EE
Sbjct: 206 EEDVEED-EEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDY 264
Query: 1916 GEKEEGLEEG 1925
+ E + G
Sbjct: 265 DTRSEASDSG 274
Score = 52.4 bits (124), Expect = 1e-05
Identities = 29/72 (40%), Positives = 42/72 (58%), Gaps = 2/72 (2%)
Query: 1856 DEDVKQILKMIEP--EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEA 1913
DE+V++ + E E EEEEEE+EEEE EEE+EEE E+DE + +E D + E +
Sbjct: 212 DEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEAS 271
Query: 1914 AEGEKEEGLEEG 1925
G + +G
Sbjct: 272 DSGSESVSFTDG 283
Score = 51.6 bits (122), Expect = 2e-05
Identities = 25/49 (51%), Positives = 35/49 (71%)
Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
TE EEE EE+ E+E+ EE E++EE ++ E+EE+EEEE E E+EE
Sbjct: 198 TENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEE 246
Score = 50.8 bits (120), Expect = 3e-05
Identities = 25/51 (49%), Positives = 35/51 (68%)
Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
E EEE EE+ EE++E E++ +E+E E +EE+EEEE E E+EE EE
Sbjct: 199 ENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEE 249
Score = 49.7 bits (117), Expect = 7e-05
Identities = 27/53 (50%), Positives = 35/53 (66%), Gaps = 1/53 (1%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKE-DEEKEEEEAAEGEKEEGLEE 1924
E+ + EEEG EED EE EE EE+ +++E DE+ EEEE E E+EE EE
Sbjct: 193 EQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEE 245
Score = 47.4 bits (111), Expect = 4e-04
Identities = 23/67 (34%), Positives = 40/67 (59%)
Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG 1916
E+ +++ + E + +E+ EE+EEEE EEE+EEE+EE+E E + + EE + +
Sbjct: 210 EEDEEVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSE 269
Query: 1917 EKEEGLE 1923
+ G E
Sbjct: 270 ASDSGSE 276
Score = 42.7 bits (99), Expect = 0.009
Identities = 22/53 (41%), Positives = 30/53 (56%)
Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
T DE+ E +EE EED EE + +ED E++EE +GE+EE EE
Sbjct: 185 TGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEE 237
Score = 42.0 bits (97), Expect = 0.015
Identities = 19/49 (38%), Positives = 31/49 (63%)
Query: 1876 EEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
+E+ E EEE EE E++EE ++ E++E+ +E+ E E+EE EE
Sbjct: 192 DEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEE 240
Score = 39.3 bits (90), Expect = 0.10
Identities = 19/55 (34%), Positives = 30/55 (54%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
E E EEEEEE+EEE ++E ++++E ++ +T E D E +G G
Sbjct: 234 EEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSG 288
Score = 33.9 bits (76), Expect = 4.2
Identities = 22/75 (29%), Positives = 34/75 (45%)
Query: 1851 MGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
+G+ D + + + EV +EE + E DE+ + EE E++ EE EE
Sbjct: 155 IGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEE 214
Query: 1911 EEAAEGEKEEGLEEG 1925
E E EE E+G
Sbjct: 215 VEEDAEEDEEVDEDG 229
>gi|60498973 myelin transcription factor 1-like [Homo sapiens]
Length = 1184
Score = 57.8 bits (138), Expect = 3e-07
Identities = 28/52 (53%), Positives = 41/52 (78%), Gaps = 1/52 (1%)
Query: 1874 EEEEEDEEEEGEEEDE-EEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
+E+EEDEE + EEE+E EE++ED++E ++ EDEE+EEEE E E+EE E+
Sbjct: 119 DEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENED 170
Score = 55.5 bits (132), Expect = 1e-06
Identities = 26/52 (50%), Positives = 38/52 (73%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
E +E++E+EEG+ E+EEE EE++E+ ++ ED E EEEE E E+EE EE
Sbjct: 116 EPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEE 167
Score = 54.3 bits (129), Expect = 3e-06
Identities = 28/55 (50%), Positives = 38/55 (69%), Gaps = 1/55 (1%)
Query: 1867 EPEVFTEEEEEEDEEEEGE-EEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
EP EE+EE D EEE E EE++E+ +ED E+ E+E+EE+EEEE E E E+
Sbjct: 116 EPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENED 170
Score = 50.8 bits (120), Expect = 3e-05
Identities = 25/55 (45%), Positives = 38/55 (69%)
Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKE 1909
GDED + E E EEE+E+D+E+ + EDEEE+EE+EEE +E+E+E+ +
Sbjct: 118 GDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENEDHQ 172
Score = 48.9 bits (115), Expect = 1e-04
Identities = 27/62 (43%), Positives = 38/62 (61%), Gaps = 2/62 (3%)
Query: 1865 MIEPEVFTEEEEEEDEEEEGEE--EDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGL 1922
M E E EE ED +E G+E EDEE E+EEE +E ED++++ E+ + E+EE
Sbjct: 99 MDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEE 158
Query: 1923 EE 1924
EE
Sbjct: 159 EE 160
Score = 43.1 bits (100), Expect = 0.007
Identities = 22/55 (40%), Positives = 36/55 (65%), Gaps = 2/55 (3%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE--KEEEEAAEGEKEEGLEEG 1925
+ + ED +E+ E+E EE E+++E +++EDEE +EEEE E E E+ E+G
Sbjct: 92 DSDGTEDMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDG 146
Score = 40.0 bits (92), Expect = 0.059
Identities = 23/51 (45%), Positives = 32/51 (62%), Gaps = 4/51 (7%)
Query: 1877 EEDEEEEGEEEDEEEKEEDEEETAQEKEDE---EKEEEEAAEGEKEEGLEE 1924
+E ++ +G E D +EKEEDE E E DE E EE+E + E+EE +EE
Sbjct: 88 DECDDSDGTE-DMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEE 137
Score = 38.9 bits (89), Expect = 0.13
Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 1875 EEEEDEEEEGEEEDEEEKEEDEE---ETAQEKEDEEKEEEEAAEGEKEEGL 1922
E+EE+EEEE EEE+EEE+ ED + + +D EK++ E + + L
Sbjct: 150 EDEEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDEL 200
Score = 38.1 bits (87), Expect = 0.22
Identities = 25/71 (35%), Positives = 40/71 (56%), Gaps = 2/71 (2%)
Query: 3663 LTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTAL-TEKSKLDEDYL 3721
+ E+ +D +D+ E+EEEEEE EE++ + HQ+ H +R TEK + D
Sbjct: 135 IEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDE- 193
Query: 3722 YMAYADIMAKS 3732
Y Y +++AKS
Sbjct: 194 YDNYDELVAKS 204
Score = 37.7 bits (86), Expect = 0.29
Identities = 20/61 (32%), Positives = 34/61 (55%)
Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGLLQ 1928
+V EEEEEE+EEEE EEE+ E+ + + T ++ E+ + +E + + LL
Sbjct: 148 DVEDEEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLN 207
Query: 1929 M 1929
+
Sbjct: 208 L 208
Score = 37.4 bits (85), Expect = 0.38
Identities = 21/51 (41%), Positives = 32/51 (62%), Gaps = 2/51 (3%)
Query: 1876 EEEDEEEEGEEEDEEEKEEDEE--ETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
+E D+ + E+ DE+E++E EE E E DE++E+EE E+EE EE
Sbjct: 88 DECDDSDGTEDMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEE 138
>gi|21735415 centromere protein B [Homo sapiens]
Length = 599
Score = 57.4 bits (137), Expect = 4e-07
Identities = 29/52 (55%), Positives = 37/52 (71%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
EEEEEE+EEEEGE E+EEE+ E+EEE E E+ +EEE EG+ + EE
Sbjct: 409 EEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEE 460
Score = 55.5 bits (132), Expect = 1e-06
Identities = 36/72 (50%), Positives = 43/72 (59%), Gaps = 11/72 (15%)
Query: 1863 LKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDE-----EETAQEKEDEEK------EEE 1911
LK E EEEEEE+EE EGEEE+EE +EE+E EE +E+E EE+ EEE
Sbjct: 401 LKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEE 460
Query: 1912 EAAEGEKEEGLE 1923
E E EGLE
Sbjct: 461 EEDEESSSEGLE 472
Score = 53.5 bits (127), Expect = 5e-06
Identities = 29/52 (55%), Positives = 34/52 (65%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
EEEEEE+EEEE E E EEE+EE EEE + E EE EEE E E + +E
Sbjct: 407 EEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDE 458
Score = 52.8 bits (125), Expect = 9e-06
Identities = 27/44 (61%), Positives = 33/44 (75%)
Query: 1881 EEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
+ EGEEE+EEE+EE+EEE E+E+EE EEEE GE EE EE
Sbjct: 402 KSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEE 445
Score = 52.4 bits (124), Expect = 1e-05
Identities = 29/71 (40%), Positives = 43/71 (60%), Gaps = 9/71 (12%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDE---------EEKEEDEEETAQEKEDEEKEEEEAAEGE 1917
E E EE E E+EEEEGEEE+E EE+E +EE E+EE++EE ++EG
Sbjct: 412 EEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEGDVDSDEEEEEDEESSSEGL 471
Query: 1918 KEEGLEEGLLQ 1928
+ E +G+++
Sbjct: 472 EAEDWAQGVVE 482
Score = 50.8 bits (120), Expect = 3e-05
Identities = 27/56 (48%), Positives = 37/56 (66%)
Query: 1870 VFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
+ T + E +EEEE EEE+EEE+ E EEE + +E+EE+ E GE+EE EEG
Sbjct: 397 ITTSLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEEEG 452
Score = 38.5 bits (88), Expect = 0.17
Identities = 56/209 (26%), Positives = 77/209 (36%), Gaps = 35/209 (16%)
Query: 4322 RLTAREAATAVAALLWAAVTRAGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELLA 4381
+L EA VAA W AV + A AG FGGG T L +
Sbjct: 358 QLGLTEALHFVAAA-WQAVEPSDIAACFREAG---------FGGG----PNATITTSLKS 403
Query: 4382 GMPDPTSDEVHGEQPAGPGGDADGEGASEGA-GDAAEGAGDEEEAVHEAGPGGADG---- 4436
+ +E E+ G G + + EG E G E G+EEE V E G +D
Sbjct: 404 EGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEE-VEEEGDVDSDEEEEE 462
Query: 4437 -------AVAVTDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPP 4489
+ D E G G G A+ PT L G + + +
Sbjct: 463 DEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPT------LHFLEGGEDSDSDSEE 516
Query: 4490 EPEPEPEPELEPEKADAENGEKEEVPEPT 4518
E + E + E E + D E+G+ EVP P+
Sbjct: 517 EDDEEEDDEDEDDDDDEEDGD--EVPVPS 543
Score = 38.5 bits (88), Expect = 0.17
Identities = 19/41 (46%), Positives = 28/41 (68%)
Query: 1886 EEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEGL 1926
+ + EE+EE+EEE +E+ + E+EEEE E E+E G E L
Sbjct: 402 KSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEEL 442
Score = 37.7 bits (86), Expect = 0.29
Identities = 14/27 (51%), Positives = 23/27 (85%)
Query: 1872 TEEEEEEDEEEEGEEEDEEEKEEDEEE 1898
++ EEE+DEEE+ E+ED+++ EED +E
Sbjct: 512 SDSEEEDDEEEDDEDEDDDDDEEDGDE 538
Score = 37.4 bits (85), Expect = 0.38
Identities = 15/34 (44%), Positives = 23/34 (67%)
Query: 1882 EEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
E GE+ D + +EED+EE E ED++ +EE+ E
Sbjct: 505 EGGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDE 538
Score = 35.0 bits (79), Expect = 1.9
Identities = 15/51 (29%), Positives = 30/51 (58%)
Query: 1852 GIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQE 1902
G +G ++ Q + E + + + +EE++ EE+DE+E ++D+EE E
Sbjct: 488 GAYGAQEEAQCPTLHFLEGGEDSDSDSEEEDDEEEDDEDEDDDDDEEDGDE 538
Score = 35.0 bits (79), Expect = 1.9
Identities = 16/37 (43%), Positives = 25/37 (67%), Gaps = 1/37 (2%)
Query: 1871 FTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEE 1907
F E E+ D + E EE+DEEE +EDE++ E++ +E
Sbjct: 503 FLEGGEDSDSDSE-EEDDEEEDDEDEDDDDDEEDGDE 538
Score = 34.7 bits (78), Expect = 2.5
Identities = 23/88 (26%), Positives = 39/88 (44%), Gaps = 30/88 (34%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEE------------------------------EKEEDE 1896
E +V ++EEEEEDEE E + E E ED
Sbjct: 451 EGDVDSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGEDS 510
Query: 1897 EETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
+ ++E++DEE+++E+ + + EE +E
Sbjct: 511 DSDSEEEDDEEEDDEDEDDDDDEEDGDE 538
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 57.4 bits (137), Expect = 4e-07
Identities = 62/261 (23%), Positives = 117/261 (44%), Gaps = 20/261 (7%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
+E +++ +M E E EEEE E+E + +++EEK +++EE E+E++ +E+EE
Sbjct: 582 EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMW 641
Query: 1916 GEKE---EGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQAN 1972
++E E E+ Q +LPE + H E +QE E E+ K Q
Sbjct: 642 EQEEKMWEQEEKMWEQQRLPEQKEKLWEH--EKMQEQEKMQEQEEKIWEQEKMEKKTQEQ 699
Query: 1973 QRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEE----IR 2028
++ + + E ++ RE +EQ + + ++ E++ + E+
Sbjct: 700 EKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWE 759
Query: 2029 QDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEE 2088
Q+ + Q L +L E+ E+E ++ EK+R ++K EE+ +E
Sbjct: 760 QEEKMWEQQRLPEQKEKLWEHEKMQEQE-----KIWEQEEKMRDQEEKMRGQEEKMRGQE 814
Query: 2089 SKPRSLQELVSHMVVRWAQED 2109
K R +E + W QE+
Sbjct: 815 EKMRGQEEKM------WGQEE 829
Score = 53.5 bits (127), Expect = 5e-06
Identities = 61/259 (23%), Positives = 116/259 (44%), Gaps = 45/259 (17%)
Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG 1916
E +++ KM E E T ++EE+ +EEE E E++ E+EE +++E +K+EE E
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483
Query: 1917 EKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSR 1976
E++E Q +LPE + + + +++Q + E + E+ D Q
Sbjct: 484 EEKE-----WQQQRLPEQKE-------KLWEQEKMQEQEEKIWEQEEKIRD-----QEEM 526
Query: 1977 YGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQ 2036
+G + + R+ + QE M Q + D+E +E R + Q
Sbjct: 527 WG-----------QEKKMWRQEKMREQED-QMWEQEEKMRDQEQKMWDQEERMEKKTQEQ 574
Query: 2037 DLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRSLQE 2096
+ + +EE+ EE + R + E+ +++++EEK +E +E K + +E
Sbjct: 575 EK------KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE----QEEKMQEQEE 624
Query: 2097 LVSHMVVRWAQEDFVQSPE 2115
+ W QE+ +Q E
Sbjct: 625 KM------WEQEEKMQEQE 637
Score = 49.3 bits (116), Expect = 1e-04
Identities = 59/264 (22%), Positives = 113/264 (42%), Gaps = 19/264 (7%)
Query: 1864 KMIEPEVFTE-------EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG 1916
K + P+V T +EEE E+E + +EEK +EE +E+E + +E+EE
Sbjct: 259 KFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKM-W 317
Query: 1917 EKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSR 1976
+E+ L E +++ E + L E ++++Q + E + E+ ++ + R
Sbjct: 318 RQEKRLREQEKELREQEKELREQKELREQ--EEQMQEQEEKMWEQEEKMREQEEKMWRQE 375
Query: 1977 YGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQ 2036
L + M E R +E R Q++ + + E+ E++R++ Q
Sbjct: 376 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
Query: 2037 DLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEE---KPEEERSAEESKPRS 2093
+ + +EE+ +EE + R + E+ ++++EE K EE +E K
Sbjct: 436 EK------KTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
Query: 2094 LQELVSHMVVRWAQEDFVQSPELV 2117
Q L W QE + E +
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEEKI 513
Score = 48.1 bits (113), Expect = 2e-04
Identities = 67/278 (24%), Positives = 116/278 (41%), Gaps = 51/278 (18%)
Query: 1864 KMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLE 1923
KM E E E+EE+ +E+E + +++EEK ++EE QE+E++ E+EE E+EE +
Sbjct: 597 KMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKM-WEQEEKMW 655
Query: 1924 EGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRSRYGLLIKA 1983
E Q +LPE + H E +QE E E+ K Q ++ +
Sbjct: 656 E---QQRLPEQKEKLWEH--EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710
Query: 1984 FSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEI------------RQDL 2031
+ E ++ RE +EQ + + ++ E++ + E+ +Q L
Sbjct: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRL 770
Query: 2032 LDFHQDLLAHCGIQLDG---EEEEP---EEETTLGS--RLMSLLEKVRLVKKK------- 2076
+ + L H +Q E+EE +EE G ++ EK+R ++K
Sbjct: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
Query: 2077 ------------------EEKPEEERSAEESKPRSLQE 2096
EEK EE+ +E K R +E
Sbjct: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE 868
Score = 45.4 bits (106), Expect = 0.001
Identities = 60/255 (23%), Positives = 111/255 (43%), Gaps = 42/255 (16%)
Query: 1864 KMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGE-----K 1918
KM E E+E+E E+E E +++E E EE+ +++E ++EE+ E E +
Sbjct: 315 KMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ 374
Query: 1919 EEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERY--VDKLQANQRSR 1976
EE L E QM+ E K++ + D+ L+ + E + + + V+K++ ++ +
Sbjct: 375 EERLWEQEKQMREQEQ-KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQ 433
Query: 1977 YGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLDFHQ 2036
E ++TR+ QE+ + + K +EE+ +E +
Sbjct: 434 -------------EQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK-------- 472
Query: 2037 DLLAHCGIQLDGEEE---EPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKPRS 2093
+ +EE E EE+ RL EK+ +K +E+ EE+ +E K R
Sbjct: 473 ---------MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ-EEKIWEQEEKIRD 522
Query: 2094 LQELVSHMVVRWAQE 2108
+E+ W QE
Sbjct: 523 QEEMWGQEKKMWRQE 537
Score = 45.1 bits (105), Expect = 0.002
Identities = 51/267 (19%), Positives = 123/267 (46%), Gaps = 12/267 (4%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
++++++ ++ E E +E+EE+ E+E + ++EEK +EE E+E + +E+E+
Sbjct: 334 EKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMR 393
Query: 1916 GEKEEGLEEGLLQMKLPESVKLQ--MCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQ 1973
++E E+ + E ++ Q M +E +++ E E +K+Q +
Sbjct: 394 DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQE---EKMQEEE 450
Query: 1974 RSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEE--IRQDL 2031
R R + M E R +E + QE+ NM Q + ++ P +E Q+
Sbjct: 451 RIRE----REKKMREEEETMREQEEKMQKQEE-NMWEQEEKEWQQQRLPEQKEKLWEQEK 505
Query: 2032 LDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESKP 2091
+ ++ + ++ +EE +E + + ++ ++ +++E+ ++E+ + +
Sbjct: 506 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 565
Query: 2092 RSLQELVSHMVVRWAQEDFVQSPELVR 2118
R ++ W QE+ ++ E +R
Sbjct: 566 RMEKKTQEQEKKTWDQEEKMREEERMR 592
Score = 37.4 bits (85), Expect = 0.38
Identities = 18/56 (32%), Positives = 38/56 (67%), Gaps = 2/56 (3%)
Query: 1867 EPEVFTEEEEEEDEEEEGEE--EDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEE 1920
E +++ +EE+ +EE+ EE + +EEK ++EE + +E++ +E+EE G++E+
Sbjct: 835 EEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEK 890
Score = 36.6 bits (83), Expect = 0.65
Identities = 22/62 (35%), Positives = 39/62 (62%), Gaps = 4/62 (6%)
Query: 1867 EPEVFTEEEEEEDEEEE--GEEEDEEEKEEDEEETAQEKEDEEKEEEEAA--EGEKEEGL 1922
E +++ +EE+ +EE+ G+EE EEK + +EE +E+E++ + +EE + EK G
Sbjct: 828 EEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887
Query: 1923 EE 1924
EE
Sbjct: 888 EE 889
Score = 36.2 bits (82), Expect = 0.85
Identities = 20/60 (33%), Positives = 38/60 (63%), Gaps = 2/60 (3%)
Query: 1867 EPEVFTEEEEEEDEEEE--GEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
E +++ +EE+ +EE+ G+EE +EE EE Q +E++ +E+EE G++E+ E+
Sbjct: 821 EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 57.4 bits (137), Expect = 4e-07
Identities = 31/57 (54%), Positives = 38/57 (66%)
Query: 1869 EVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
EV + E E+EEEEGE E+EE + E+EE +E+E E K EEE EGE EE EEG
Sbjct: 818 EVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEG 874
Score = 57.4 bits (137), Expect = 4e-07
Identities = 35/66 (53%), Positives = 40/66 (60%), Gaps = 7/66 (10%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKE-------EEEAAEGEKE 1919
E E EE E E EEEEGEEE EEE E +EE + +E+EE E EE EGE+E
Sbjct: 978 EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEE 1037
Query: 1920 EGLEEG 1925
EG EEG
Sbjct: 1038 EGEEEG 1043
Score = 53.9 bits (128), Expect = 4e-06
Identities = 30/53 (56%), Positives = 34/53 (64%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
EE E E EEEEGE E EEE E + EE E + EE+ EE EGE+EEG EG
Sbjct: 889 EEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941
Score = 53.9 bits (128), Expect = 4e-06
Identities = 30/53 (56%), Positives = 34/53 (64%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
E EEEE E E EEE E E EE+ E +E E E +EEE EGE+EEG EEG
Sbjct: 947 EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEG 999
Score = 53.9 bits (128), Expect = 4e-06
Identities = 32/62 (51%), Positives = 42/62 (67%), Gaps = 2/62 (3%)
Query: 1866 IEPEVFTEEEEEEDEEEEGEEEDEE-EKEEDEEETAQEKEDEEKEEEEAAE-GEKEEGLE 1923
+E EV EE E E EEEEGEEE EE EKE + EE + +E+EE+EE + E GE+E +
Sbjct: 1021 VEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQ 1080
Query: 1924 EG 1925
+G
Sbjct: 1081 DG 1082
Score = 53.5 bits (127), Expect = 5e-06
Identities = 33/63 (52%), Positives = 38/63 (60%), Gaps = 4/63 (6%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEE----DEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGL 1922
E E EE E E+EE EGEEE +EEE E EE +E E EE+ EE EGE+EEG
Sbjct: 825 EREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGE 884
Query: 1923 EEG 1925
EG
Sbjct: 885 GEG 887
Score = 53.5 bits (127), Expect = 5e-06
Identities = 35/62 (56%), Positives = 39/62 (62%), Gaps = 4/62 (6%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDE-EETAQEKEDEEKEEEEAAEGEKE---EGL 1922
E E EEEE E EEEEGE + EEE EE E EE +E E E +EEE EGE+E EG
Sbjct: 837 EEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE 896
Query: 1923 EE 1924
EE
Sbjct: 897 EE 898
Score = 52.4 bits (124), Expect = 1e-05
Identities = 33/71 (46%), Positives = 42/71 (59%)
Query: 1855 GDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAA 1914
G+E+ ++ E E E EEE+ E EGEEE E E EE+E E E+E E + EEE
Sbjct: 858 GEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 917
Query: 1915 EGEKEEGLEEG 1925
EG+ EE EEG
Sbjct: 918 EGKGEEEGEEG 928
Score = 52.0 bits (123), Expect = 1e-05
Identities = 32/67 (47%), Positives = 43/67 (64%), Gaps = 9/67 (13%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEK--------EEDEEETAQEKEDEEKEEEEAAEGEK 1918
E E EEE E EEEEG+ E+EEEK E +E E +EKE+ E+++EE A G++
Sbjct: 726 EMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERA-GKE 784
Query: 1919 EEGLEEG 1925
E+G EEG
Sbjct: 785 EKGEEEG 791
Score = 52.0 bits (123), Expect = 1e-05
Identities = 30/53 (56%), Positives = 35/53 (66%), Gaps = 1/53 (1%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
EE E E EE EGE E+EE + E EEE +E+ +EE E EE EGE EE EEG
Sbjct: 968 EEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEE-EEG 1019
Score = 51.2 bits (121), Expect = 3e-05
Identities = 29/59 (49%), Positives = 37/59 (62%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
E E E E E EE +GE E+EEE+ E EEE + +E+E + EEE EG+ EE EEG
Sbjct: 807 EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEG 865
Score = 51.2 bits (121), Expect = 3e-05
Identities = 31/56 (55%), Positives = 35/56 (62%), Gaps = 3/56 (5%)
Query: 1873 EEEEEEDEEEEGEEEDEE---EKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
EE E E EEEEGE E E+ E EE+E E E+E+ E E EE EGE EEG EG
Sbjct: 926 EEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG 981
Score = 50.4 bits (119), Expect = 4e-05
Identities = 27/59 (45%), Positives = 38/59 (64%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
E E EE+EE E E GE E+ + + E+EEE + +E+E + EEE EGE+EEG +G
Sbjct: 800 ETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKG 858
Score = 50.1 bits (118), Expect = 6e-05
Identities = 30/58 (51%), Positives = 36/58 (62%), Gaps = 5/58 (8%)
Query: 1873 EEEEEEDEEEEGEEEDEEEK-----EEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
EEEE E E E+GE E EEE+ EE+E E E+E E + EE EGE+EEG EG
Sbjct: 933 EEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEG 990
Score = 49.7 bits (117), Expect = 7e-05
Identities = 29/53 (54%), Positives = 32/53 (60%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
EEE E + EEEGE E EEE+ E E E E E EE+E E E E EEG EG
Sbjct: 880 EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEG 932
Score = 49.7 bits (117), Expect = 7e-05
Identities = 34/63 (53%), Positives = 38/63 (60%), Gaps = 4/63 (6%)
Query: 1867 EPEVFTEEEEEEDE-EEEGEEEDEEEKEEDEEETAQEKEDEEKE---EEEAAEGEKEEGL 1922
E E E E EE+E E EGEEE E E EE+E E E+E EE E EEE EGE E+G
Sbjct: 886 EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGE 945
Query: 1923 EEG 1925
EG
Sbjct: 946 GEG 948
Score = 49.7 bits (117), Expect = 7e-05
Identities = 31/62 (50%), Positives = 38/62 (61%), Gaps = 3/62 (4%)
Query: 1867 EPEVFTEEEEEEDE---EEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLE 1923
E E E EEEE E EEEGEE + E +EE+ E ++ E E +EEE EGE+EEG
Sbjct: 905 EEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEG 964
Query: 1924 EG 1925
EG
Sbjct: 965 EG 966
Score = 49.3 bits (116), Expect = 1e-04
Identities = 31/54 (57%), Positives = 36/54 (66%), Gaps = 2/54 (3%)
Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEA-AEGEKE-EGLEEG 1925
E EEE+ E EGEEE E E EE E E +E+ + E EEEE EGE+E EG EEG
Sbjct: 956 EGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEG 1009
Score = 49.3 bits (116), Expect = 1e-04
Identities = 32/55 (58%), Positives = 36/55 (65%), Gaps = 2/55 (3%)
Query: 1873 EEEEEEDEEEEGEEEDEE-EKEEDEEETAQEKEDEEKEEEEAAEGE-KEEGLEEG 1925
EEE E + EEEGE E EE E E +EEE E E+EE EEE EGE +EEG EG
Sbjct: 959 EEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEG 1013
Score = 49.3 bits (116), Expect = 1e-04
Identities = 29/59 (49%), Positives = 35/59 (59%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
E E EEE E +EE EGE E+EEE E + E +E E E +EEE EGE+ E EG
Sbjct: 994 EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052
Score = 48.9 bits (115), Expect = 1e-04
Identities = 44/147 (29%), Positives = 62/147 (42%), Gaps = 8/147 (5%)
Query: 4394 EQPAGPGGDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGG 4453
E+ G G + +GEG E G+ EG G+EEE E G +G + G + E G
Sbjct: 906 EEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGE---EEEGEWEGEEEEG 962
Query: 4454 LGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEE 4513
G+ + E EG + G +G EEE E E E E E E+ GE+EE
Sbjct: 963 EGEGEEEGEGEGEEGEGEGEEEEGEG-EGEEEE----GEEEGEEEGEGEEEGEGEGEEEE 1017
Query: 4514 VPEPTPEPPKKQAPPSPPPKKEEAGGE 4540
E E ++ ++ E GE
Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGE 1044
Score = 48.5 bits (114), Expect = 2e-04
Identities = 32/64 (50%), Positives = 37/64 (57%), Gaps = 5/64 (7%)
Query: 1867 EPEVFTEEEEEED----EEEEGEE-EDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
E E EEEEE++ EE EGEE E E EKEE E + + EEK EEE +GE EE
Sbjct: 740 EEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEE 799
Query: 1922 LEEG 1925
EG
Sbjct: 800 ETEG 803
Score = 48.5 bits (114), Expect = 2e-04
Identities = 30/59 (50%), Positives = 33/59 (55%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
E E E EEE E E EEE E E EE+ E +E+E E K EEE EGE E EEG
Sbjct: 879 EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEG 937
Score = 48.5 bits (114), Expect = 2e-04
Identities = 28/53 (52%), Positives = 35/53 (66%), Gaps = 1/53 (1%)
Query: 1874 EEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGE-KEEGLEEG 1925
EEE E+ E EGEEE+ E + ED E +E+E E + EEE EGE +EEG EG
Sbjct: 922 EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEG 974
Score = 48.1 bits (113), Expect = 2e-04
Identities = 68/268 (25%), Positives = 92/268 (34%), Gaps = 48/268 (17%)
Query: 4365 GGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDADGEGASEGAGDAAEGAGDEEE 4424
GG VE K E G + +E GE+ G G + +GEG E G+ EG + EE
Sbjct: 816 GGEVEEGKGEREEEEEEG--EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEE 873
Query: 4425 AVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGV-DGV 4483
E +G G E G G+ E EG + + G +G
Sbjct: 874 GEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGE 933
Query: 4484 EEELPPEPE------PEPEPELEPEKADAENGEKEEVPEPTPEPPKKQAPPSPPPKKEEA 4537
EEE E E E E E E E+ + E +EE E + + EE
Sbjct: 934 EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE 993
Query: 4538 GGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPGEDDMEGSA 4597
GE GE E + + GE++ EG
Sbjct: 994 EGEEEGEEEGEG--------------------------------EEEGEGEGEEEEEGEV 1021
Query: 4598 AGDVSGAGSGGSSGWGLGAGEEAEGDED 4625
G+V G G G GEE EG+E+
Sbjct: 1022 EGEVEGEE-------GEGEGEEEEGEEE 1042
Score = 47.8 bits (112), Expect = 3e-04
Identities = 25/49 (51%), Positives = 31/49 (63%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEG 1921
+E EE EEE GE E+EE E+EEE E ++E + EE E EKEEG
Sbjct: 725 QEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEG 773
Score = 47.8 bits (112), Expect = 3e-04
Identities = 25/56 (44%), Positives = 36/56 (64%), Gaps = 7/56 (12%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEE-------TAQEKEDEEKEEEEAAEGEKEEG 1921
E+ EEE ++ EGEEE+ E + E++EE +E + E +EEEE EGE+EEG
Sbjct: 785 EKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG 840
Score = 47.8 bits (112), Expect = 3e-04
Identities = 65/247 (26%), Positives = 87/247 (35%), Gaps = 50/247 (20%)
Query: 4389 DEVHGEQPAGPG-GDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFR 4447
D+ GE+ G G+ EG G+ EG G+ EE E +G +G
Sbjct: 792 DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE 851
Query: 4448 PEGAGGLGDMGDTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAE 4507
EG G + G+ E EG +G EEE E E E E E E E+ +
Sbjct: 852 EEGEGKGEEEGEEGEGEEEGEEGEG--------EGEEEEGEGEGEEEGEGEGEEEEGE-- 901
Query: 4508 NGEKEEVPEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLA 4567
GE EE E E + + K EE G E GE E + +
Sbjct: 902 -GEGEEEGEGEGEEEEGEG------KGEEEGEEGEGEGEEEEGEGEGEDGEG-------- 946
Query: 4568 LFLAFAINFILLFYKVSDSPPGE---DDMEGSAAGDVSGAGSG------GSSGWGLGAGE 4618
+ GE ++ EG G+ G G G G G G GE
Sbjct: 947 ---------------EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGE 991
Query: 4619 EAEGDED 4625
E EG+E+
Sbjct: 992 EEEGEEE 998
Score = 47.8 bits (112), Expect = 3e-04
Identities = 29/58 (50%), Positives = 34/58 (58%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEE 1924
E EV E E EE E E EEE EEE EE E+E E+ +EEEE EG+ +E EE
Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEE 1075
Score = 47.4 bits (111), Expect = 4e-04
Identities = 28/59 (47%), Positives = 35/59 (59%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
E E E EEE + EEEGE E EEE+E + E + +E E + EEE E E EE +EG
Sbjct: 992 EEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEG 1050
Score = 47.0 bits (110), Expect = 5e-04
Identities = 29/82 (35%), Positives = 46/82 (56%), Gaps = 1/82 (1%)
Query: 1856 DEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAE 1915
+E+ ++ +E E E EEE+ EEEGEE ++E + E+ +E+E+EE + +E E
Sbjct: 1015 EEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGE 1074
Query: 1916 GEKE-EGLEEGLLQMKLPESVK 1936
E E + EE K+ SVK
Sbjct: 1075 EENERQDGEEYKKVSKIKGSVK 1096
Score = 46.2 bits (108), Expect = 8e-04
Identities = 28/60 (46%), Positives = 35/60 (58%), Gaps = 1/60 (1%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEE-EKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
E E ++E ++ EE GEEE E E+EE + E +EKE E KEE E E E E EEG
Sbjct: 714 EREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEG 773
Score = 46.2 bits (108), Expect = 8e-04
Identities = 29/65 (44%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEK---EEGLE 1923
E E E EEEE+ E EGE E EE + E EEE +E+ +E ++E E E + EE E
Sbjct: 1006 EEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEE 1065
Query: 1924 EGLLQ 1928
EG Q
Sbjct: 1066 EGKYQ 1070
Score = 45.8 bits (107), Expect = 0.001
Identities = 25/53 (47%), Positives = 33/53 (62%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
E E EE+ E EGEEE+ E K E+E E + + +EE+ E E +GE E EEG
Sbjct: 901 EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEG 953
Score = 45.8 bits (107), Expect = 0.001
Identities = 29/61 (47%), Positives = 35/61 (57%), Gaps = 9/61 (14%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEE---------ETAQEKEDEEKEEEEAAEGEKEEGLE 1923
E EEE +EE EGEEE E E EE+EE E + + +EE+ EEE E EKE E
Sbjct: 994 EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGE 1053
Query: 1924 E 1924
E
Sbjct: 1054 E 1054
Score = 45.1 bits (105), Expect = 0.002
Identities = 29/73 (39%), Positives = 38/73 (52%), Gaps = 9/73 (12%)
Query: 1857 EDVKQILKMIEPEVFTEEEEEEDEEEEG---------EEEDEEEKEEDEEETAQEKEDEE 1907
E K++ + E + EE+E+ E E+G EE EEE E EEE +E+EE
Sbjct: 691 EGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEE 750
Query: 1908 KEEEEAAEGEKEE 1920
KE E EGE EE
Sbjct: 751 KEGEGKEEGEGEE 763
Score = 45.1 bits (105), Expect = 0.002
Identities = 63/233 (27%), Positives = 79/233 (33%), Gaps = 50/233 (21%)
Query: 4406 EGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEG-------AGGL---G 4455
EG E G+ E GD EE + G G +G +G + EG AG
Sbjct: 729 EGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGE 788
Query: 4456 DMGDTTPAEPPTPEGSPILKRKLG-VDGVEEELPPEPEPEPEPELEPEKADAENGEKEEV 4514
+ GD E EG K + G V+G E E E E E E E+ + E GE+EE
Sbjct: 789 EEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE-GEEEEG 847
Query: 4515 PEPTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAI 4574
E K + EE G E GE E
Sbjct: 848 EGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE---------------------------- 879
Query: 4575 NFILLFYKVSDSPPGEDDMEGSAAG-DVSGAGSGGSSGWGLGAGEEAEGDEDE 4626
+ GE + EG G + G G G G G G EE EG +E
Sbjct: 880 ---------EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEE 923
Score = 45.1 bits (105), Expect = 0.002
Identities = 36/69 (52%), Positives = 41/69 (59%), Gaps = 10/69 (14%)
Query: 1867 EPEVFTEEEE-----EEDEEE-EGEEEDEE---EKEEDEEETAQEKEDEEKEEEEAAEGE 1917
E E EEEE EE+ EE EGEEE EE E EE+E E E+E E + EEE EGE
Sbjct: 844 EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGE 903
Query: 1918 -KEEGLEEG 1925
+EEG EG
Sbjct: 904 GEEEGEGEG 912
Score = 44.3 bits (103), Expect = 0.003
Identities = 26/56 (46%), Positives = 34/56 (60%), Gaps = 4/56 (7%)
Query: 1873 EEEEEEDEEEEGEEEDEEEKEEDEEETAQEKED----EEKEEEEAAEGEKEEGLEE 1924
E E+E E+EE ++ D EE+E+ E E +KE EE EEE EGE+EEG E
Sbjct: 691 EGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDRE 746
Score = 43.9 bits (102), Expect = 0.004
Identities = 30/59 (50%), Positives = 36/59 (61%), Gaps = 2/59 (3%)
Query: 1867 EPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
E E E E E EEEEGE + EEE EE E E +E+E E + E+ EGE+EEG EG
Sbjct: 901 EGEGEEEGEGE-GEEEEGEGKGEEEGEEGEGE-GEEEEGEGEGEDGEGEGEEEEGEWEG 957
Score = 42.4 bits (98), Expect = 0.012
Identities = 27/58 (46%), Positives = 34/58 (58%), Gaps = 8/58 (13%)
Query: 1874 EEEEEDEEEEGEEEDEE-----EKEEDEEETAQEKEDEEKEEEEAAEG---EKEEGLE 1923
+EE E EE EGE E EE E+ +EE +E+ D+ + EEE EG EKEEG E
Sbjct: 756 KEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGE 813
Score = 42.0 bits (97), Expect = 0.015
Identities = 24/62 (38%), Positives = 37/62 (59%), Gaps = 1/62 (1%)
Query: 1860 KQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKE 1919
K+ K + E ++E E+ ++E +E EE EE+ E +E+ D E+EEE+ EG KE
Sbjct: 699 KEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEG-KE 757
Query: 1920 EG 1921
EG
Sbjct: 758 EG 759
Score = 40.8 bits (94), Expect = 0.034
Identities = 47/155 (30%), Positives = 62/155 (40%), Gaps = 12/155 (7%)
Query: 4364 GGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGG----DADGEGASEGAGDAAEGA 4419
G G EG + E G + E GE+ G + +GEG EG G+ EG
Sbjct: 919 GKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGE 978
Query: 4420 GDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAEPPTPEGSPILKRKLG 4479
G+ EE E G G + +G EG G G+ E EG + G
Sbjct: 979 GEGEE---EEGEGEGEEEEGEEEG---EEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEG 1032
Query: 4480 VDGVEEELPPE-PEPEPEPELEPEKADAENGEKEE 4513
+G EEE E E E E E E + + E E+EE
Sbjct: 1033 -EGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066
Score = 40.0 bits (92), Expect = 0.059
Identities = 24/66 (36%), Positives = 39/66 (59%), Gaps = 5/66 (7%)
Query: 1864 KMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKE---- 1919
++ E E + + + EE E++E E+ ++E+ ++ EE +E E E EEEE E+E
Sbjct: 695 ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEE-EHGEGEEEEGDREEEEEKEG 753
Query: 1920 EGLEEG 1925
EG EEG
Sbjct: 754 EGKEEG 759
Score = 38.5 bits (88), Expect = 0.17
Identities = 22/64 (34%), Positives = 40/64 (62%), Gaps = 7/64 (10%)
Query: 1869 EVFTEEEEEEDEEEEG----EEEDEEEKEEDEEETAQEKEDEEKEEEEAAEG---EKEEG 1921
E + +EE E+ E+++G E E EKE E+E ++++ EE+E++E +G E+ +
Sbjct: 667 EHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQE 726
Query: 1922 LEEG 1925
+EEG
Sbjct: 727 MEEG 730
Score = 33.5 bits (75), Expect = 5.5
Identities = 30/118 (25%), Positives = 46/118 (38%), Gaps = 5/118 (4%)
Query: 1793 EAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMG 1852
E +LSP + K + +GE +D D E + K + G
Sbjct: 512 EKSLKLSPV-----QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQG 566
Query: 1853 IFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEE 1910
IF + I + EV EE+E E+ +G +E+E E +EE +EK E
Sbjct: 567 IFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTE 624
Score = 32.7 bits (73), Expect = 9.4
Identities = 35/135 (25%), Positives = 53/135 (39%), Gaps = 5/135 (3%)
Query: 4406 EGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAEP 4465
EG ++ G+A +G + E G GA+ D + E G G+M E
Sbjct: 638 EGKAKSVGEAEDGPEGRGDGTCEEGSSGAE---HWQDEEREKGEKDKGRGEMERPGEGEK 694
Query: 4466 PTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPEPTPEPPKKQ 4525
E KR G + ++E + E E+E E + E+GE EE E +K+
Sbjct: 695 ELAEKEEWKKRD-GEEQEQKEREQGHQKERNQEME-EGGEEEHGEGEEEEGDREEEEEKE 752
Query: 4526 APPSPPPKKEEAGGE 4540
+ EE GE
Sbjct: 753 GEGKEEGEGEEVEGE 767
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 208,535,304
Number of Sequences: 37866
Number of extensions: 10791165
Number of successful extensions: 144652
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 866
Number of HSP's successfully gapped in prelim test: 970
Number of HSP's that attempted gapping in prelim test: 66469
Number of HSP's gapped (non-prelim): 42813
length of query: 5038
length of database: 18,247,518
effective HSP length: 124
effective length of query: 4914
effective length of database: 13,552,134
effective search space: 66595186476
effective search space used: 66595186476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.