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Search of human proteins with 112799847
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]
(4967 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens] 9993 0.0
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 6628 0.0
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 6623 0.0
gi|126032338 ryanodine receptor 3 [Homo sapiens] 4946 0.0
gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo s... 164 2e-39
gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo ... 162 8e-39
gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isofor... 162 1e-38
gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isofor... 162 1e-38
gi|37588869 ring finger protein 123 [Homo sapiens] 82 1e-14
gi|45387949 ring finger and SPRY domain containing 1 [Homo sapiens] 69 1e-10
gi|4826686 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [Homo sapiens] 58 3e-07
gi|157412282 ash2-like isoform b [Homo sapiens] 49 1e-04
gi|157412280 ash2-like isoform a [Homo sapiens] 49 1e-04
gi|39812378 RAN binding protein 9 [Homo sapiens] 45 0.001
gi|209862789 microtubule associated monoxygenase, calponin and L... 45 0.001
gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2 [H... 45 0.001
gi|17975763 myelin transcription factor 1 [Homo sapiens] 45 0.002
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 44 0.003
gi|40538736 RAN binding protein 10 [Homo sapiens] 44 0.003
gi|221219020 NYD-SP11 protein [Homo sapiens] 44 0.004
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 44 0.004
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 44 0.005
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 44 0.005
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 44 0.005
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 44 0.005
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 0.005
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 0.005
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 0.005
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 0.005
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 44 0.005
>gi|112799847 cardiac muscle ryanodine receptor [Homo sapiens]
Length = 4967
Score = 9993 bits (25933), Expect = 0.0
Identities = 4967/4967 (100%), Positives = 4967/4967 (100%)
Query: 1 MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP 60
MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP
Sbjct: 1 MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP 60
Query: 61 DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL 120
DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL
Sbjct: 61 DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL 120
Query: 121 LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD 180
LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD
Sbjct: 121 LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD 180
Query: 181 LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH 240
LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH
Sbjct: 181 LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH 240
Query: 241 MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV 300
MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV
Sbjct: 241 MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV 300
Query: 301 TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV 360
TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV
Sbjct: 301 TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV 360
Query: 361 CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIR 420
CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIR
Sbjct: 361 CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIR 420
Query: 421 STVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR 480
STVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR
Sbjct: 421 STVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR 480
Query: 481 ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL 540
ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL
Sbjct: 481 ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL 540
Query: 541 IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL 600
IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL
Sbjct: 541 IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL 600
Query: 601 LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF 660
LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF
Sbjct: 601 LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF 660
Query: 661 LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD 720
LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD
Sbjct: 661 LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD 720
Query: 721 DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE 780
DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE
Sbjct: 721 DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE 780
Query: 781 NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY 840
NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY
Sbjct: 781 NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY 840
Query: 841 KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL 900
KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL
Sbjct: 841 KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL 900
Query: 901 GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDK 960
GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDK
Sbjct: 901 GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDK 960
Query: 961 VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI 1020
VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI
Sbjct: 961 VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI 1020
Query: 1021 QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG 1080
QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG
Sbjct: 1021 QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG 1080
Query: 1081 TGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF 1140
TGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF
Sbjct: 1081 TGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF 1140
Query: 1141 KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG 1200
KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG
Sbjct: 1141 KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG 1200
Query: 1201 FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ 1260
FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ
Sbjct: 1201 FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ 1260
Query: 1261 VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG 1320
VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG
Sbjct: 1261 VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG 1320
Query: 1321 GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK 1380
GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK
Sbjct: 1321 GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK 1380
Query: 1381 PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPAN 1440
PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPAN
Sbjct: 1381 PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPAN 1440
Query: 1441 VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR 1500
VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR
Sbjct: 1441 VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR 1500
Query: 1501 NNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI 1560
NNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI
Sbjct: 1501 NNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI 1560
Query: 1561 KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ 1620
KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ
Sbjct: 1561 KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ 1620
Query: 1621 CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV 1680
CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV
Sbjct: 1621 CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV 1680
Query: 1681 DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFP 1740
DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFP
Sbjct: 1681 DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFP 1740
Query: 1741 DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVK 1800
DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVK
Sbjct: 1741 DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVK 1800
Query: 1801 EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEE 1860
EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEE
Sbjct: 1801 EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEE 1860
Query: 1861 SDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH 1920
SDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH
Sbjct: 1861 SDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH 1920
Query: 1921 RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK 1980
RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK
Sbjct: 1921 RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK 1980
Query: 1981 DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK 2040
DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK
Sbjct: 1981 DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK 2040
Query: 2041 KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR 2100
KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR
Sbjct: 2041 KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR 2100
Query: 2101 ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN 2160
ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN
Sbjct: 2101 ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN 2160
Query: 2161 LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY 2220
LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY
Sbjct: 2161 LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY 2220
Query: 2221 LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML 2280
LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML
Sbjct: 2221 LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML 2280
Query: 2281 VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG 2340
VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG
Sbjct: 2281 VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG 2340
Query: 2341 NGLLAAMEEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLG 2400
NGLLAAMEEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLG
Sbjct: 2341 NGLLAAMEEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLG 2400
Query: 2401 RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF 2460
RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF
Sbjct: 2401 RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF 2460
Query: 2461 CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL 2520
CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL
Sbjct: 2461 CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL 2520
Query: 2521 CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL 2580
CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL
Sbjct: 2521 CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL 2580
Query: 2581 RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL 2640
RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL
Sbjct: 2581 RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL 2640
Query: 2641 SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN 2700
SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN
Sbjct: 2641 SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN 2700
Query: 2701 FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY 2760
FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY
Sbjct: 2701 FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY 2760
Query: 2761 KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG 2820
KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG
Sbjct: 2761 KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG 2820
Query: 2821 YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK 2880
YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK
Sbjct: 2821 YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK 2880
Query: 2881 EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI 2940
EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI
Sbjct: 2881 EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI 2940
Query: 2941 LEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE 3000
LEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE
Sbjct: 2941 LEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE 3000
Query: 3001 KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF 3060
KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF
Sbjct: 3001 KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF 3060
Query: 3061 LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED 3120
LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED
Sbjct: 3061 LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED 3120
Query: 3121 LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI 3180
LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI
Sbjct: 3121 LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI 3180
Query: 3181 YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP 3240
YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP
Sbjct: 3181 YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP 3240
Query: 3241 MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA 3300
MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA
Sbjct: 3241 MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA 3300
Query: 3301 VFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFT 3360
VFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFT
Sbjct: 3301 VFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFT 3360
Query: 3361 TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFV 3420
TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFV
Sbjct: 3361 TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFV 3420
Query: 3421 VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI 3480
VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI
Sbjct: 3421 VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI 3480
Query: 3481 CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDD 3540
CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDD
Sbjct: 3481 CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDD 3540
Query: 3541 TSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVV 3600
TSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVV
Sbjct: 3541 TSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVV 3600
Query: 3601 ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKR 3660
ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKR
Sbjct: 3601 ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKR 3660
Query: 3661 VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEME 3720
VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEME
Sbjct: 3661 VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEME 3720
Query: 3721 KQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDY 3780
KQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDY
Sbjct: 3721 KQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDY 3780
Query: 3781 LKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF 3840
LKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF
Sbjct: 3781 LKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF 3840
Query: 3841 RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE 3900
RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE
Sbjct: 3841 RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE 3900
Query: 3901 QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ 3960
QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ
Sbjct: 3901 QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ 3960
Query: 3961 DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF 4020
DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF
Sbjct: 3961 DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF 4020
Query: 4021 LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY 4080
LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY
Sbjct: 4021 LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY 4080
Query: 4081 EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG 4140
EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG
Sbjct: 4081 EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG 4140
Query: 4141 SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM 4200
SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM
Sbjct: 4141 SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM 4200
Query: 4201 QLAAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLS 4260
QLAAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLS
Sbjct: 4201 QLAAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLS 4260
Query: 4261 LKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVE 4320
LKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVE
Sbjct: 4261 LKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVE 4320
Query: 4321 GAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIF 4380
GAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIF
Sbjct: 4321 GAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIF 4380
Query: 4381 GLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPE 4440
GLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPE
Sbjct: 4381 GLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPE 4440
Query: 4441 KAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFY 4500
KAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFY
Sbjct: 4441 KAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFY 4500
Query: 4501 NMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYV 4560
NMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYV
Sbjct: 4501 NMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYV 4560
Query: 4561 LEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQ 4620
LEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQ
Sbjct: 4561 LEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQ 4620
Query: 4621 PSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFS 4680
PSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFS
Sbjct: 4621 PSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFS 4680
Query: 4681 DAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFA 4740
DAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFA
Sbjct: 4681 DAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFA 4740
Query: 4741 AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD 4800
AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD
Sbjct: 4741 AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD 4800
Query: 4801 TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLA 4860
TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLA
Sbjct: 4801 TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLA 4860
Query: 4861 IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLF 4920
IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLF
Sbjct: 4861 IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLF 4920
Query: 4921 FLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN 4967
FLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
Sbjct: 4921 FLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN 4967
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 6628 bits (17196), Expect = 0.0
Identities = 3306/5073 (65%), Positives = 4025/5073 (79%), Gaps = 155/5073 (3%)
Query: 6 EGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSIC 65
EGEDE+QFLRTDDEVVLQC+AT+ KEQ KLCLAAEGFGNRLCFLE TSN++NVPPDL+IC
Sbjct: 5 EGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAIC 64
Query: 66 TFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSY 125
FVLEQSLSVRALQEMLANTVE ++++QGGGHRTLLYGHAILLRH++
Sbjct: 65 CFVLEQSLSVRALQEMLANTVEAG------------VESSQGGGHRTLLYGHAILLRHAH 112
Query: 126 SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS 185
S MYL CL+TSRS TDKLAFDVGLQED TGEACWWT+HPASKQRSEGEKVRVGDD+ILVS
Sbjct: 113 SRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVS 172
Query: 186 VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECL 245
VSSERYLHLS +G L VDA+F QTLW++ PI S E +G++ GG VLRL HGHMDECL
Sbjct: 173 VSSERYLHLSTASGELQVDASFMQTLWNMNPICSRCE--EGFVTGGHVLRLFHGHMDECL 230
Query: 246 TVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKY 305
T+ + ++QRR V+YEGGAV HARSLWRLE LR++WSGSH+RWGQP R+RHVTTG+Y
Sbjct: 231 TISPAD-SDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQY 289
Query: 306 LSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQH 365
L+L ED+ L+++D KA K+T+F FR SKEKLDV +++V+GMG EIKYG+S+C++QH
Sbjct: 290 LALTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQH 349
Query: 366 VDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFL 425
V +GLWLTY + D K++R+G +++KA++H EGHMDD +SL+R Q EES+ AR+I ST L
Sbjct: 350 VASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGL 409
Query: 426 FNRFIRGLDALSKKAKAST----VDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRA 481
+N+FI+ LD+ S K + S LPIE V LSLQDLI YF PP E L+HE+KQ++LR+
Sbjct: 410 YNQFIKSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRS 469
Query: 482 LKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALI 541
L+NRQ+LFQEEGM+++VL CIDRL+VY++AAHFA+ AG EA ESWK I+N LYELLA+LI
Sbjct: 470 LRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLI 529
Query: 542 RGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLL 601
RGNR NCA FS +LDWL+S+L+RLEASSGILEVL+CVL+ESPE LNII+E HIKSIISLL
Sbjct: 530 RGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLL 589
Query: 602 DKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFL 661
DKHGRNHKVLDVLCSLCVC+GVAVRSNQ LI +NLLPGR+LLLQT L+N+V+S+RPNIF+
Sbjct: 590 DKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFV 649
Query: 662 GVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDD 721
G +EG+ QY KWY+E+MVD PF+TA+ATHLRVGWA TEGY+PYPG GE WGGNGVGDD
Sbjct: 650 GRAEGTTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDD 709
Query: 722 LFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFEN 781
L+SYGFDGLHLW+G +AR V+SP QHLL +DVISCCLDLS PSISFRING PVQG+FE+
Sbjct: 710 LYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFES 769
Query: 782 FNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYK 841
FN+DGLFFPVVSFSAG+KVRFLLGGRHGEFKFLPPPGYAPC+EAVLP+E+L +E +EY+
Sbjct: 770 FNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYR 829
Query: 842 QERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELG 901
+E L+GP+ L+ F P PVDT QIVLPPHLERIREKLAENIHELW + +IE G
Sbjct: 830 REGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQG 889
Query: 902 WQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKV 961
W YGPVRDDNKR HPCLV+F LPE ERNYNLQMS ETLKTLLALGCHVG++DE AED +
Sbjct: 890 WTYGPVRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNL 949
Query: 962 KKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQ 1021
KK KLPK Y +++GYKPAP+DLS ++LTP+Q +VD+LAEN HNVWARDR+ QGW+Y
Sbjct: 950 KKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAV 1009
Query: 1022 QDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGT 1081
QD+ RRNPRLVPY LLD+ TK+SN+DSL +AVRTLLGYGYN+E PDQ+ +
Sbjct: 1010 QDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVEN--QSR 1067
Query: 1082 GERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFK 1141
+R RIFRAEK+Y V++GRWYFEFE VT G+MRVGW+RP +PD ELG+DE A+ F+G +
Sbjct: 1068 CDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHR 1127
Query: 1142 AQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGF 1201
QRWH G+E +GR WQ GDVVGCM+D+ E+T++FTLNGE+L+ DSGSE AF++ ++GDGF
Sbjct: 1128 GQRWHLGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGF 1187
Query: 1202 IPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQV 1261
+PVCSLG QVG +N G+DVS+L++F ICGLQEG+EPFA+N R +T W SK LPQF V
Sbjct: 1188 LPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPV 1247
Query: 1262 PSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGG 1321
P H H EV+R+DGT+D+ PCL++T +++GSQNS +++F RLS+P++ + F + AG
Sbjct: 1248 PLEHPHYEVSRVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHF-RCTAGA 1306
Query: 1322 LPGA--GLFGPKND-LEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPE--------- 1369
P A GL P D + D D+E L ++A G + KE T E
Sbjct: 1307 TPLAPPGLQPPAEDEARAAEPDPDYENLRRSAGGW---SEAENGKEGTAKEGAPGGTPQA 1363
Query: 1370 --------FNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSA-----RLTEDVL-ADDRD 1415
N KD EK K+ FL + K T A RL DV+ AD+RD
Sbjct: 1364 GGEAQPARAENEKDATTEK--NKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRD 1421
Query: 1416 DYDFLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGK 1475
D + ++ T+TYYYSVR+F GQEP+ VW GW+T D+HQ+D FDL +VR VTVT+GDE+G
Sbjct: 1422 DPEIILNTTTYYYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGN 1481
Query: 1476 VHESIKRSNCYMVCAGESMSPG-QGR-NNNGLEIGCVVDAASGLLTFIANGKELSTYYQV 1533
VH S+K SNCYMV G+ +SPG QGR ++ L IGC+VD A+GL+TF ANGKE +T++QV
Sbjct: 1482 VHSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQV 1541
Query: 1534 EPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSH 1593
EP+TKLFPAVF T NV QFELG+ KN+MPLSA +F+SE KNP PQCPPRL +Q L
Sbjct: 1542 EPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMP 1601
Query: 1594 VLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKF 1653
V WSRMPN FL+V+ R ER GW VQC +PL M+LHIPEENR +DILEL+E+ +L +F
Sbjct: 1602 VSWSRMPNHFLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRF 1661
Query: 1654 HYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSS 1713
H HTLRLY AVCALGN+RVAHALCSHVD+ QLL+A+E+ ++PG LRAGYYDLLI IHL S
Sbjct: 1662 HSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLES 1721
Query: 1714 YATARLMMNNEYIVPMTEETKSITLFP------DENKKHGLPGIGLSTSLRPRMQFSSPS 1767
+R M +EYIVP+T ET++ITLFP + + +HGLPG+G++TSLRP FS P
Sbjct: 1722 ACRSRRSMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPC 1781
Query: 1768 FVS------ISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPL 1821
FV+ + + SP PL+ L+ K ++ML EAV++G HARDPVGG+ EF FVP+
Sbjct: 1782 FVAALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPV 1841
Query: 1822 IKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPE------EESDTLEKELSVDDAKL 1875
+KL TLL+MGIF +ED+K IL++IEP VF E E EE D EKE ++
Sbjct: 1842 LKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQ 1901
Query: 1876 QGAG----EEEAKGGKRP---KEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAF 1928
+ EEEA G++ +EGLLQMKLPE VKLQMC LL+Y CD +++HR+E++ AF
Sbjct: 1902 EKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAF 1961
Query: 1929 SDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKD--DKSEC 1986
++ +V KLQ NQR RY +++A +M+AA TAR+T+EFRSPPQEQINMLL FKD D+ +C
Sbjct: 1962 AERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDC 2021
Query: 1987 PCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEK 2046
P PEEIR LLDFH+DL+ HCGI+LD + + + T+ RL+SL+EKV +KKK+ EK
Sbjct: 2022 PLPEEIRQDLLDFHQDLLAHCGIQLDGEEE-EPEEETTLGSRLMSLLEKVRLVKKKE-EK 2079
Query: 2047 PVE---SDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALP 2103
P E ++ K +LQ+L+S +VRWAQE ++ PELVRAMF LLHRQYDG+G L+RALP
Sbjct: 2080 PEEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALP 2139
Query: 2104 KTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMR 2163
+ YTI+ SVEDT++LL LGQIRSLL V+MG +EE LMI+ +G+IMNNKVFYQHPNLMR
Sbjct: 2140 RAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMR 2199
Query: 2164 ALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLE 2223
ALGMHETVMEVMVNVLGGGESKEI FPKMV +CCRFLCYFCRISRQNQ++MFDHLSYLLE
Sbjct: 2200 ALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLE 2259
Query: 2224 NSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSK 2283
NS +GL M+GSTPLDVAAASV+DNNELALAL+E DLEKVV YLAGCGLQSC MLV+K
Sbjct: 2260 NSGIGL---GMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAK 2316
Query: 2284 GYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGL 2343
GYPDIGWNP GERYLDFLRFAVF NGESVEENANVVVRLLIR+PECFGPALRGEGG+GL
Sbjct: 2317 GYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGL 2376
Query: 2344 LAAMEEAIKIAEDPSRDGPSPNSGSSKT-LDTEEEEDDTIHMGNAIMTFYSALIDLLGRC 2402
LAA+EEAI+I+EDP+RDGP + E E++ +H+G+AIM+FY+ALIDLLGRC
Sbjct: 2377 LAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRC 2436
Query: 2403 APEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCP 2462
APEMHLI AGKGEA+RIR+ILRSL+PL DLVG+IS+ Q+PT+ KDG +V+P MSA F P
Sbjct: 2437 APEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVP 2496
Query: 2463 DHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCT 2522
DHKA+MVLFLDRVYGIE QDFLLH+L+VGFLPD+RAAASLDTA S T+MALALNRYLC
Sbjct: 2497 DHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCL 2556
Query: 2523 AVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRP 2582
AVLPL+T+CAPLFAGTEH A ++DS+LHTVYRLS+G SLTKAQRD IE CL+S+C +RP
Sbjct: 2557 AVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRP 2616
Query: 2583 SMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSR 2642
SM+QHLLRRLVFDVP+LNE AKMPLKLLTNHYERCWKYYCLP GW NFG SEEELHL+R
Sbjct: 2617 SMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTR 2676
Query: 2643 KLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFN 2702
KLFWGIFD+L+ KKY+ EL+++A+PCL A+AGALPPDY++++Y S EK++++D+EGNF+
Sbjct: 2677 KLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFD 2736
Query: 2703 PQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKL 2762
P+PV+T N+ IPEKL+ FINK+AE++H+KW+ DK+ N W YGE + K P+++PYK
Sbjct: 2737 PRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKT 2796
Query: 2763 LSEKEKEIYRWPIKESLKTMLAWGWRIERTREG-DSMALYNRTRRISQTSQVSVDAAHGY 2821
SEK+KEIYRWPIKESLK M+AW W IE+ REG + +TR+ISQ++Q + D GY
Sbjct: 2797 FSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQ-TYDPREGY 2855
Query: 2822 SPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKE 2881
+P+ D+S VTLSR+L AMAE +AENYHN W +KKK ELE+KGGG HPLLVPYDTLTAKE
Sbjct: 2856 NPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKE 2915
Query: 2882 KAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYIL 2941
KA+DREKAQ++LKFLQ+NGYAV+RG KD+ELD+ SIEKRFA+ FLQQL+R++D + ++I
Sbjct: 2916 KARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIA 2975
Query: 2942 EFDG-GSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE 3000
+ S G+ E P+EQEIKFFAK++LPLI+QYF NH LYFLS ++ L SGGHASNKE
Sbjct: 2976 HLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKE 3035
Query: 3001 KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF 3060
KEM+TSLFCKL LVRHR+SLFG DA ++VNCLHIL ++LDARTVMK+G E VK+ LR+F
Sbjct: 3036 KEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSF 3095
Query: 3061 LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED 3120
++A+ED+EK +ENL+ G+ + R Q KGV Q + YTTVALLP+L++LF+HI QHQFG+D
Sbjct: 3096 FESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDD 3155
Query: 3121 LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI 3180
+IL+DVQVSCYR L S+Y+LGT+K+ YVE+ R ALGECLA A A PVAFLE L+++N
Sbjct: 3156 VILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNA 3215
Query: 3181 YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP 3240
S+Y TKS RERA L LP +VE++CP+IP LE+LM +I LAESG RYT+MPHV+E+ LP
Sbjct: 3216 CSVYTTKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLP 3275
Query: 3241 MLCSYMSRWWEHGPENNPER----AEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWM 3296
MLCSY+ RWWE GPE P A CTA+ S+H+N+LLGNIL+II NNLGIDE +WM
Sbjct: 3276 MLCSYLPRWWERGPEAPPSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWM 3335
Query: 3297 KRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLIL 3356
KRLAVF+QPI+++ +P+LL++HF+P + +L+K+A VVSEE+ L+ EA+ + E ELL+
Sbjct: 3336 KRLAVFAQPIVSRARPELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVR 3395
Query: 3357 DEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREE 3416
DEF+ L RDLYA YPLLIR+VD NRA+WL EPNP AEELFRMV E+FIYWSKSHNFKREE
Sbjct: 3396 DEFSVLCRDLYALYPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREE 3455
Query: 3417 QNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPI 3476
QNFVVQNEINNMSFL D KSKM+K+ SDQER K KR+GDRYS+QTSLIVA LK++LPI
Sbjct: 3456 QNFVVQNEINNMSFLTADNKSKMAKSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPI 3515
Query: 3477 GLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLE-DPAIRWQMALYKDLP 3535
GLN+CAP DQ+LI LAK R++LKDT++EVR+ + +N+HLQGK+E P++RWQMALY+ +P
Sbjct: 3516 GLNMCAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVP 3575
Query: 3536 NRTDDTSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQR 3595
R +D DPEK V RV +++ VL++L+Q EHP +SKKAVWHKLLSKQR
Sbjct: 3576 GREEDADDPEKIVRRVQEVSAVLYYLDQ------------TEHPYKSKKAVWHKLLSKQR 3623
Query: 3596 KRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEED 3655
+RAVVACFRM PLYNLP HRA N+FL+ Y+ +WI TE+H FED++I+DL+K G + EE+
Sbjct: 3624 RRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEE 3683
Query: 3656 E-GTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDE---EDDDGEEEV 3711
E K+ DPLHQL+L FSRTALTEK KL+ED+LYMAYADIMAKSCH E E+ + EEEV
Sbjct: 3684 EVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEEV 3743
Query: 3712 K-SFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGN 3770
+ SFEEK+MEKQ+LLYQQARLH RGAAEMVLQ ISA KGETG MV++TLKLGI+ILNGGN
Sbjct: 3744 EVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGN 3803
Query: 3771 STVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEG------ 3824
+ VQQKMLDYLK+KK+VGFFQS+ LMQ+CSVLDLNAFERQNKAEGLGMV E+G
Sbjct: 3804 AEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQ 3863
Query: 3825 SGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQES 3884
+GEKV+ DDEFT DLFRFLQLLCEGHN+DFQNYLRTQTGN TT+NIII TVDYLLR+QES
Sbjct: 3864 NGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQES 3923
Query: 3885 ISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAV 3944
ISDFYWYYSGKDVI+EQG+RNFSKA+ VAKQVFN+LTEYIQGPCTGNQQSLAHSRLWDAV
Sbjct: 3924 ISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAV 3983
Query: 3945 VGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLV 4004
VGFLHVFAHM MKL+QDSSQIELLKEL+DLQKDMVVMLLS+LEGNVVNG I +QMVDMLV
Sbjct: 3984 VGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLV 4043
Query: 4005 ESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETE 4064
ESS+NVEMILKFFDMFLKLKD+ S+ F++Y D +G+ISK+DF KAM+S K ++ E +
Sbjct: 4044 ESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQ 4103
Query: 4065 FLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAES 4124
FLLSC+E DENE ++ EEF RF EPA+DIGFNVAVLLTNLSEH+P+D RL FLELAES
Sbjct: 4104 FLLSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLELAES 4163
Query: 4125 VLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKE 4184
+L YF+P+LGRIEIMG+++RIER+YFEISE++R QWE PQVKESKRQFIFDVVNEGGE E
Sbjct: 4164 ILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAE 4223
Query: 4185 KMELFVNFCEDTIFEMQLAAQISESD-----LNERSANKEESEKERPEEQGPRMAFFSIL 4239
KMELFV+FCEDTIFEMQ+AAQISE + + A E+ E EE + +
Sbjct: 4224 KMELFVSFCEDTIFEMQIAAQISEPEGEPETDEDEGAGAAEAGAEGAEEGAAGLEGTAAT 4283
Query: 4240 TVRSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVA 4299
A + +R LS +SL++++++++++T ++ TA + W+ A
Sbjct: 4284 AAAGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTRAGAAGA 4343
Query: 4300 SVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAALP 4359
G ++ L GG LVEGAKK+ V ELLA MPDPT DEV G+ G +
Sbjct: 4344 GAAAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDADGEGA 4403
Query: 4360 SEDLTDLKE-LTEESDLLSD-----IFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMP 4413
SE D E +E + + + G +GG ++ + D P P
Sbjct: 4404 SEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPAEPPTP 4463
Query: 4414 E----VQEKFQEQKAKEE---EKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLH 4466
E ++ K +EE E E + E + EPEKA+ E+GEKEE E + +Q
Sbjct: 4464 EGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEE-VPEPTPEPPKKQAP 4522
Query: 4467 THRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSS 4526
+ E FW ++ + K LNY +RNFY +R LALF+AFAINFILLFYKVS S
Sbjct: 4523 PSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSP 4582
Query: 4527 VVEGKELPTRSSSENAKVTSLDSSSHRIIA------------VHYVLEESSGYMEPTLRI 4574
E ++ ++ + + S SS + A V+Y LEES+GYMEP LR
Sbjct: 4583 PGE-DDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYFLEESTGYMEPALRC 4641
Query: 4575 LAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLV 4634
L++LHT+++F CIIGY CLKVPLVIFKREKE+ARKLEFDGLYITEQP +DD+KGQWDRLV
Sbjct: 4642 LSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQWDRLV 4701
Query: 4635 INTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSL 4694
+NT SFP+NYWDKFVKRKV+DK+G+ YGR+RI+ELLGMD A L+ + A ++KP L
Sbjct: 4702 LNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEIT-AHNERKPNPPPGL 4760
Query: 4695 SAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLR 4754
L SIDVKYQ+WK GV+FTDNSFLYL WYM MS+LGHYNNFFFAAHLLDIAMG KTLR
Sbjct: 4761 LTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMGVKTLR 4820
Query: 4755 TILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYM 4814
TILSSVTHNGKQLV+TVGLLAVVVYLYTVVAFNFFRKFYNKSED D PDMKCDDM+TCY+
Sbjct: 4821 TILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYL 4880
Query: 4815 FHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELR 4874
FHMYVGVRAGGGIGDEIEDPAGDEYE+YR++FDITFFFFVIVILLAIIQGLIIDAFGELR
Sbjct: 4881 FHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELR 4940
Query: 4875 DQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHT 4934
DQQEQVKEDMETKCFICGIG+DYFDT PHGFETHTL+EHNLANY+FFLMYLINKDETEHT
Sbjct: 4941 DQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHT 5000
Query: 4935 GQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN 4967
GQESYVWKMYQERCW+FFPAGDCFRKQYEDQL+
Sbjct: 5001 GQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5033
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 6623 bits (17183), Expect = 0.0
Identities = 3307/5078 (65%), Positives = 4025/5078 (79%), Gaps = 160/5078 (3%)
Query: 6 EGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSIC 65
EGEDE+QFLRTDDEVVLQC+AT+ KEQ KLCLAAEGFGNRLCFLE TSN++NVPPDL+IC
Sbjct: 5 EGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAIC 64
Query: 66 TFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSY 125
FVLEQSLSVRALQEMLANTVE ++++QGGGHRTLLYGHAILLRH++
Sbjct: 65 CFVLEQSLSVRALQEMLANTVEAG------------VESSQGGGHRTLLYGHAILLRHAH 112
Query: 126 SGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS 185
S MYL CL+TSRS TDKLAFDVGLQED TGEACWWT+HPASKQRSEGEKVRVGDD+ILVS
Sbjct: 113 SRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDIILVS 172
Query: 186 VSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECL 245
VSSERYLHLS +G L VDA+F QTLW++ PI S E +G++ GG VLRL HGHMDECL
Sbjct: 173 VSSERYLHLSTASGELQVDASFMQTLWNMNPICSRCE--EGFVTGGHVLRLFHGHMDECL 230
Query: 246 TVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGKY 305
T+ + ++QRR V+YEGGAV HARSLWRLE LR++WSGSH+RWGQP R+RHVTTG+Y
Sbjct: 231 TISPAD-SDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRVRHVTTGQY 289
Query: 306 LSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQH 365
L+L ED+ L+++D KA K+T+F FR SKEKLDV +++V+GMG EIKYG+S+C++QH
Sbjct: 290 LALTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMGPPEIKYGESLCFVQH 349
Query: 366 VDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFL 425
V +GLWLTY + D K++R+G +++KA++H EGHMDD +SL+R Q EES+ AR+I ST L
Sbjct: 350 VASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIHSTNGL 409
Query: 426 FNRFIRGLDALSKKAKAST----VDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRA 481
+N+FI+ LD+ S K + S LPIE V LSLQDLI YF PP E L+HE+KQ++LR+
Sbjct: 410 YNQFIKSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIYFEPPSEDLQHEEKQSKLRS 469
Query: 482 LKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALI 541
L+NRQ+LFQEEGM+++VL CIDRL+VY++AAHFA+ AG EA ESWK I+N LYELLA+LI
Sbjct: 470 LRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLI 529
Query: 542 RGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLL 601
RGNR NCA FS +LDWL+S+L+RLEASSGILEVL+CVL+ESPE LNII+E HIKSIISLL
Sbjct: 530 RGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLL 589
Query: 602 DKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFL 661
DKHGRNHKVLDVLCSLCVC+GVAVRSNQ LI +NLLPGR+LLLQT L+N+V+S+RPNIF+
Sbjct: 590 DKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFV 649
Query: 662 GVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDD 721
G +EG+ QY KWY+E+MVD PF+TA+ATHLRVGWA TEGY+PYPG GE WGGNGVGDD
Sbjct: 650 GRAEGTTQYSKWYFEVMVDEVTPFLTAQATHLRVGWALTEGYTPYPGAGEGWGGNGVGDD 709
Query: 722 LFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFEN 781
L+SYGFDGLHLW+G +AR V+SP QHLL +DVISCCLDLS PSISFRING PVQG+FE+
Sbjct: 710 LYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVISCCLDLSVPSISFRINGCPVQGVFES 769
Query: 782 FNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYK 841
FN+DGLFFPVVSFSAG+KVRFLLGGRHGEFKFLPPPGYAPC+EAVLP+E+L +E +EY+
Sbjct: 770 FNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYR 829
Query: 842 QERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELG 901
+E L+GP+ L+ F P PVDT QIVLPPHLERIREKLAENIHELW + +IE G
Sbjct: 830 REGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQG 889
Query: 902 WQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDKV 961
W YGPVRDDNKR HPCLV+F LPE ERNYNLQMS ETLKTLLALGCHVG++DE AED +
Sbjct: 890 WTYGPVRDDNKRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNL 949
Query: 962 KKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQ 1021
KK KLPK Y +++GYKPAP+DLS ++LTP+Q +VD+LAEN HNVWARDR+ QGW+Y
Sbjct: 950 KKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAV 1009
Query: 1022 QDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGT 1081
QD+ RRNPRLVPY LLD+ TK+SN+DSL +AVRTLLGYGYN+E PDQ+ +
Sbjct: 1010 QDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVEN--QSR 1067
Query: 1082 GERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFK 1141
+R RIFRAEK+Y V++GRWYFEFE VT G+MRVGW+RP +PD ELG+DE A+ F+G +
Sbjct: 1068 CDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHR 1127
Query: 1142 AQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGF 1201
QRWH G+E +GR WQ GDVVGCM+D+ E+T++FTLNGE+L+ DSGSE AF++ ++GDGF
Sbjct: 1128 GQRWHLGSEPFGRPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGF 1187
Query: 1202 IPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQV 1261
+PVCSLG QVG +N G+DVS+L++F ICGLQEG+EPFA+N R +T W SK LPQF V
Sbjct: 1188 LPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPV 1247
Query: 1262 PSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAGG 1321
P H H EV+R+DGT+D+ PCL++T +++GSQNS +++F RLS+P++ + F + AG
Sbjct: 1248 PLEHPHYEVSRVDGTVDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHF-RCTAGA 1306
Query: 1322 LPGA--GLFGPKND-LEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPE--------- 1369
P A GL P D + D D+E L ++A G + KE T E
Sbjct: 1307 TPLAPPGLQPPAEDEARAAEPDPDYENLRRSAGGW---SEAENGKEGTAKEGAPGGTPQA 1363
Query: 1370 --------FNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSA-----RLTEDVL-ADDRD 1415
N KD EK K+ FL + K T A RL DV+ AD+RD
Sbjct: 1364 GGEAQPARAENEKDATTEK--NKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRD 1421
Query: 1416 DYDFLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGK 1475
D + ++ T+TYYYSVR+F GQEP+ VW GW+T D+HQ+D FDL +VR VTVT+GDE+G
Sbjct: 1422 DPEIILNTTTYYYSVRVFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGN 1481
Query: 1476 VHESIKRSNCYMVCAGESMSPG-QGR-NNNGLEIGCVVDAASGLLTFIANGKELSTYYQV 1533
VH S+K SNCYMV G+ +SPG QGR ++ L IGC+VD A+GL+TF ANGKE +T++QV
Sbjct: 1482 VHSSLKCSNCYMVWGGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQV 1541
Query: 1534 EPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSH 1593
EP+TKLFPAVF T NV QFELG+ KN+MPLSA +F+SE KNP PQCPPRL +Q L
Sbjct: 1542 EPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMP 1601
Query: 1594 VLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKF 1653
V WSRMPN FL+V+ R ER GW VQC +PL M+LHIPEENR +DILEL+E+ +L +F
Sbjct: 1602 VSWSRMPNHFLQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRF 1661
Query: 1654 HYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSS 1713
H HTLRLY AVCALGN+RVAHALCSHVD+ QLL+A+E+ ++PG LRAGYYDLLI IHL S
Sbjct: 1662 HSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLES 1721
Query: 1714 YATARLMMNNEYIVPMTEETKSITLFP------DENKKHGLPGIGLSTSLRPRMQFSSPS 1767
+R M +EYIVP+T ET++ITLFP + + +HGLPG+G++TSLRP FS P
Sbjct: 1722 ACRSRRSMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPC 1781
Query: 1768 FVS------ISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPL 1821
FV+ + + SP PL+ L+ K ++ML EAV++G HARDPVGG+ EF FVP+
Sbjct: 1782 FVAALPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPV 1841
Query: 1822 IKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPE------EESDTLEKELSVDDAKL 1875
+KL TLL+MGIF +ED+K IL++IEP VF E E EE D EKE ++
Sbjct: 1842 LKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQ 1901
Query: 1876 QGAG----EEEAKGGKRP---KEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAF 1928
+ EEEA G++ +EGLLQMKLPE VKLQMC LL+Y CD +++HR+E++ AF
Sbjct: 1902 EKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAF 1961
Query: 1929 SDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKD--DKSEC 1986
++ +V KLQ NQR RY +++A +M+AA TAR+T+EFRSPPQEQINMLL FKD D+ +C
Sbjct: 1962 AERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDC 2021
Query: 1987 PCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEK 2046
P PEEIR LLDFH+DL+ HCGI+LD + + + T+ RL+SL+EKV +KKK+ EK
Sbjct: 2022 PLPEEIRQDLLDFHQDLLAHCGIQLDGEEE-EPEEETTLGSRLMSLLEKVRLVKKKE-EK 2079
Query: 2047 PVE---SDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALP 2103
P E ++ K +LQ+L+S +VRWAQE ++ PELVRAMF LLHRQYDG+G L+RALP
Sbjct: 2080 PEEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALP 2139
Query: 2104 KTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMR 2163
+ YTI+ SVEDT++LL LGQIRSLL V+MG +EE LMI+ +G+IMNNKVFYQHPNLMR
Sbjct: 2140 RAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMR 2199
Query: 2164 ALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLE 2223
ALGMHETVMEVMVNVLGGGESKEI FPKMV +CCRFLCYFCRISRQNQ++MFDHLSYLLE
Sbjct: 2200 ALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLE 2259
Query: 2224 NSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSK 2283
NS +GL M+GSTPLDVAAASV+DNNELALAL+E DLEKVV YLAGCGLQSC MLV+K
Sbjct: 2260 NSGIGL---GMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQSCPMLVAK 2316
Query: 2284 GYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGL 2343
GYPDIGWNP GERYLDFLRFAVF NGESVEENANVVVRLLIR+PECFGPALRGEGG+GL
Sbjct: 2317 GYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPALRGEGGSGL 2376
Query: 2344 LAAMEEAIKIAEDPSRDGPSPNSGSSKT-LDTEEEEDDTIHMGNAIMTFYSALIDLLGRC 2402
LAA+EEAI+I+EDP+RDGP + E E++ +H+G+AIM+FY+ALIDLLGRC
Sbjct: 2377 LAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRC 2436
Query: 2403 APEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCP 2462
APEMHLI AGKGEA+RIR+ILRSL+PL DLVG+IS+ Q+PT+ KDG +V+P MSA F P
Sbjct: 2437 APEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGKDGALVQPKMSASFVP 2496
Query: 2463 DHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCT 2522
DHKA+MVLFLDRVYGIE QDFLLH+L+VGFLPD+RAAASLDTA S T+MALALNRYLC
Sbjct: 2497 DHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCL 2556
Query: 2523 AVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRP 2582
AVLPL+T+CAPLFAGTEH A ++DS+LHTVYRLS+G SLTKAQRD IE CL+S+C +RP
Sbjct: 2557 AVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMSLCRYIRP 2616
Query: 2583 SMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSR 2642
SM+QHLLRRLVFDVP+LNE AKMPLKLLTNHYERCWKYYCLP GW NFG SEEELHL+R
Sbjct: 2617 SMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTR 2676
Query: 2643 KLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFN 2702
KLFWGIFD+L+ KKY+ EL+++A+PCL A+AGALPPDY++++Y S EK++++D+EGNF+
Sbjct: 2677 KLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFD 2736
Query: 2703 PQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKL 2762
P+PV+T N+ IPEKL+ FINK+AE++H+KW+ DK+ N W YGE + K P+++PYK
Sbjct: 2737 PRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKT 2796
Query: 2763 LSEKEKEIYRWPIKESLKTMLAWGWRIERTREG-DSMALYNRTRRISQTSQVSVDAAHGY 2821
SEK+KEIYRWPIKESLK M+AW W IE+ REG + +TR+ISQ++Q + D GY
Sbjct: 2797 FSEKDKEIYRWPIKESLKAMIAWEWTIEKAREGEEEKTEKKKTRKISQSAQ-TYDPREGY 2855
Query: 2822 SPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKE 2881
+P+ D+S VTLSR+L AMAE +AENYHN W +KKK ELE+KGGG HPLLVPYDTLTAKE
Sbjct: 2856 NPQPPDLSAVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKE 2915
Query: 2882 KAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYIL 2941
KA+DREKAQ++LKFLQ+NGYAV+RG KD+ELD+ SIEKRFA+ FLQQL+R++D + ++I
Sbjct: 2916 KARDREKAQELLKFLQMNGYAVTRGLKDMELDSSSIEKRFAFGFLQQLLRWMDISQEFIA 2975
Query: 2942 EFDG-GSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE 3000
+ S G+ E P+EQEIKFFAK++LPLI+QYF NH LYFLS ++ L SGGHASNKE
Sbjct: 2976 HLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKE 3035
Query: 3001 KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF 3060
KEM+TSLFCKL LVRHR+SLFG DA ++VNCLHIL ++LDARTVMK+G E VK+ LR+F
Sbjct: 3036 KEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSF 3095
Query: 3061 LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED 3120
++A+ED+EK +ENL+ G+ + R Q KGV Q + YTTVALLP+L++LF+HI QHQFG+D
Sbjct: 3096 FESASEDIEKMVENLRLGKVSQARTQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDD 3155
Query: 3121 LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI 3180
+IL+DVQVSCYR L S+Y+LGT+K+ YVE+ R ALGECLA A A PVAFLE L+++N
Sbjct: 3156 VILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNA 3215
Query: 3181 YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP 3240
S+Y TKS RERA L LP +VE++CP+IP LE+LM +I LAESG RYT+MPHV+E+ LP
Sbjct: 3216 CSVYTTKSPRERAILGLPNSVEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLP 3275
Query: 3241 MLCSYMSRWWEHGPENNPER----AEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWM 3296
MLCSY+ RWWE GPE P A CTA+ S+H+N+LLGNIL+II NNLGIDE +WM
Sbjct: 3276 MLCSYLPRWWERGPEAPPSALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWM 3335
Query: 3297 KRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLIL 3356
KRLAVF+QPI+++ +P+LL++HF+P + +L+K+A VVSEE+ L+ EA+ + E ELL+
Sbjct: 3336 KRLAVFAQPIVSRARPELLQSHFIPTIGRLRKRAGKVVSEEEQLRLEAKAEAQEGELLVR 3395
Query: 3357 DEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREE 3416
DEF+ L RDLYA YPLLIR+VD NRA+WL EPNP AEELFRMV E+FIYWSKSHNFKREE
Sbjct: 3396 DEFSVLCRDLYALYPLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREE 3455
Query: 3417 QNFVVQNEINNMSFLITDTKSKMSKA-----AVSDQERKKMKRKGDRYSMQTSLIVAALK 3471
QNFVVQNEINNMSFL D KSKM+KA SDQER K KR+GDRYS+QTSLIVA LK
Sbjct: 3456 QNFVVQNEINNMSFLTADNKSKMAKAGDIQSGGSDQERTKKKRRGDRYSVQTSLIVATLK 3515
Query: 3472 RLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLE-DPAIRWQMAL 3530
++LPIGLN+CAP DQ+LI LAK R++LKDT++EVR+ + +N+HLQGK+E P++RWQMAL
Sbjct: 3516 KMLPIGLNMCAPTDQDLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMAL 3575
Query: 3531 YKDLPNRTDDTSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKL 3590
Y+ +P R +D DPEK V RV +++ VL++L+Q EHP +SKKAVWHKL
Sbjct: 3576 YRGVPGREEDADDPEKIVRRVQEVSAVLYYLDQ------------TEHPYKSKKAVWHKL 3623
Query: 3591 LSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAE 3650
LSKQR+RAVVACFRM PLYNLP HRA N+FL+ Y+ +WI TE+H FED++I+DL+K G +
Sbjct: 3624 LSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQ 3683
Query: 3651 PPEEDE-GTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDE---EDDD 3706
EE+E K+ DPLHQL+L FSRTALTEK KL+ED+LYMAYADIMAKSCH E E+ +
Sbjct: 3684 EEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGE 3743
Query: 3707 GEEEVK-SFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAI 3765
EEEV+ SFEEK+MEKQ+LLYQQARLH RGAAEMVLQ ISA KGETG MV++TLKLGI+I
Sbjct: 3744 AEEEVEVSFEEKQMEKQRLLYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISI 3803
Query: 3766 LNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEG- 3824
LNGGN+ VQQKMLDYLK+KK+VGFFQS+ LMQ+CSVLDLNAFERQNKAEGLGMV E+G
Sbjct: 3804 LNGGNAEVQQKMLDYLKDKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGT 3863
Query: 3825 -----SGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLL 3879
+GEKV+ DDEFT DLFRFLQLLCEGHN+DFQNYLRTQTGN TT+NIII TVDYLL
Sbjct: 3864 VINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLL 3923
Query: 3880 RVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSR 3939
R+QESISDFYWYYSGKDVI+EQG+RNFSKA+ VAKQVFN+LTEYIQGPCTGNQQSLAHSR
Sbjct: 3924 RLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSR 3983
Query: 3940 LWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQM 3999
LWDAVVGFLHVFAHM MKL+QDSSQIELLKEL+DLQKDMVVMLLS+LEGNVVNG I +QM
Sbjct: 3984 LWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQM 4043
Query: 4000 VDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYT 4059
VDMLVESS+NVEMILKFFDMFLKLKD+ S+ F++Y D +G+ISK+DF KAM+S K ++
Sbjct: 4044 VDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFS 4103
Query: 4060 QSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFL 4119
E +FLLSC+E DENE ++ EEF RF EPA+DIGFNVAVLLTNLSEH+P+D RL FL
Sbjct: 4104 GPEIQFLLSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFL 4163
Query: 4120 ELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNE 4179
ELAES+L YF+P+LGRIEIMG+++RIER+YFEISE++R QWE PQVKESKRQFIFDVVNE
Sbjct: 4164 ELAESILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNE 4223
Query: 4180 GGEKEKMELFVNFCEDTIFEMQLAAQISESD-----LNERSANKEESEKERPEEQGPRMA 4234
GGE EKMELFV+FCEDTIFEMQ+AAQISE + + A E+ E EE +
Sbjct: 4224 GGEAEKMELFVSFCEDTIFEMQIAAQISEPEGEPETDEDEGAGAAEAGAEGAEEGAAGLE 4283
Query: 4235 FFSILTVRSALFALRYNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTL 4294
+ A + +R LS +SL++++++++++T ++ TA + W+
Sbjct: 4284 GTAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTRA 4343
Query: 4295 LHFVASVFRGFFRIICSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGERKPL 4354
A G ++ L GG LVEGAKK+ V ELLA MPDPT DEV G+ G
Sbjct: 4344 GAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPGGDA 4403
Query: 4355 EAALPSEDLTDLKE-LTEESDLLSD-----IFGLDLKREGGQYKLIPHNPNAGLSDLMSN 4408
+ SE D E +E + + + G +GG ++ + D
Sbjct: 4404 DGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMGDTTPA 4463
Query: 4409 PVPMPE----VQEKFQEQKAKEE---EKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQK 4461
P PE ++ K +EE E E + E + EPEKA+ E+GEKEE E +
Sbjct: 4464 EPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEE-VPEPTPEPP 4522
Query: 4462 LRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYK 4521
+Q + E FW ++ + K LNY +RNFY +R LALF+AFAINFILLFYK
Sbjct: 4523 KKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYK 4582
Query: 4522 VSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIA------------VHYVLEESSGYME 4569
VS S E ++ ++ + + S SS + A V+Y LEES+GYME
Sbjct: 4583 VSDSPPGE-DDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYFLEESTGYME 4641
Query: 4570 PTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQ 4629
P LR L++LHT+++F CIIGY CLKVPLVIFKREKE+ARKLEFDGLYITEQP +DD+KGQ
Sbjct: 4642 PALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPEDDDVKGQ 4701
Query: 4630 WDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPK 4689
WDRLV+NT SFP+NYWDKFVKRKV+DK+G+ YGR+RI+ELLGMD A L+ + A ++KP
Sbjct: 4702 WDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLATLEIT-AHNERKPN 4760
Query: 4690 KDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMG 4749
L L SIDVKYQ+WK GV+FTDNSFLYL WYM MS+LGHYNNFFFAAHLLDIAMG
Sbjct: 4761 PPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAMG 4820
Query: 4750 FKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDM 4809
KTLRTILSSVTHNGKQLV+TVGLLAVVVYLYTVVAFNFFRKFYNKSED D PDMKCDDM
Sbjct: 4821 VKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDM 4880
Query: 4810 LTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDA 4869
+TCY+FHMYVGVRAGGGIGDEIEDPAGDEYE+YR++FDITFFFFVIVILLAIIQGLIIDA
Sbjct: 4881 MTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDA 4940
Query: 4870 FGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKD 4929
FGELRDQQEQVKEDMETKCFICGIG+DYFDT PHGFETHTL+EHNLANY+FFLMYLINKD
Sbjct: 4941 FGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKD 5000
Query: 4930 ETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN 4967
ETEHTGQESYVWKMYQERCW+FFPAGDCFRKQYEDQL+
Sbjct: 5001 ETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS 5038
>gi|126032338 ryanodine receptor 3 [Homo sapiens]
Length = 4870
Score = 4946 bits (12829), Expect = 0.0
Identities = 2469/3613 (68%), Positives = 2939/3613 (81%), Gaps = 86/3613 (2%)
Query: 1398 STSHSARLTEDVLADDRDDYDFLMQTSTY-YYSVRIFPGQEPANVWVGWITSDFHQYDTG 1456
S SHS L + + + L T+T YY++RIF GQ+P+ VWVGW+T D+H Y
Sbjct: 1299 SFSHSPCLDSEAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEK 1358
Query: 1457 FDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQ--GRNNNGLEIGCVVDAA 1514
FDL++ TVTVTLGDE+G+VHES+KRSNCYMV G+ ++ Q R+N LEIGC+VD A
Sbjct: 1359 FDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVASSQRSNRSNVDLEIGCLVDLA 1418
Query: 1515 SGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSE 1574
G+L+F ANGKEL T YQVEP+TK+FPAVF Q TS ++FQFELG++KN MPLSA +F+SE
Sbjct: 1419 MGMLSFSANGKELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFRSE 1478
Query: 1575 HKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPE 1634
KNPVPQCPPRL VQ + VLWSRMPN FLKV+ R+SER GW+VQCL+PLQ M+LHIPE
Sbjct: 1479 EKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPE 1538
Query: 1635 ENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYM 1694
ENR VDILEL EQE+L++FHYHTLRLYSAVCALGN RVA+ALCSHVD QL YAI+NKY+
Sbjct: 1539 ENRCVDILELCEQEDLMRFHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYL 1598
Query: 1695 PGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFPDENKKHGLPGIGLS 1754
PGLLR+G+YDLLI IHL+S +LMM NEYI+P+T T++I LFPDE+K+HGLPG+GL
Sbjct: 1599 PGLLRSGFYDLLISIHLASAKERKLMMKNEYIIPITSTTRNIRLFPDESKRHGLPGVGLR 1658
Query: 1755 TSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVKEGSLHARDPVGGTT 1814
T L+P +FS+P FV + + SPE PL+ L++K + MLTEAV+ H RDPVGG+
Sbjct: 1659 TCLKPGFRFSTPCFVVTGEDHQKQSPEIPLESLRTKALSMLTEAVQCSGAHIRDPVGGSV 1718
Query: 1815 EFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEESDTLEKELSVDDAK 1874
EF FVP++KL TLL+MG+F ++D++ IL LI+PSVF E + EE E+ V++
Sbjct: 1719 EFQFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSAGTEEGAEKEEVTQVEEKA 1778
Query: 1875 LQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVA 1934
++ AGE+ K + P +GLLQ +LPE VKLQMC LL YLCDC+++HR+EAIVAF D +V+
Sbjct: 1779 VE-AGEKAGK--EAPVKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVS 1835
Query: 1935 KLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRD 1994
KLQ NQ+FRYNE+MQALNMSAALTARKTKEFRSPPQEQINMLLNF+ ++ CPCPEEIR+
Sbjct: 1836 KLQANQKFRYNELMQALNMSAALTARKTKEFRSPPQEQINMLLNFQLGEN-CPCPEEIRE 1894
Query: 1995 QLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKK 2054
+L DFHEDL+ HCG+ L+E+ + ++ T G+L +LV K+ K + E+P E + +
Sbjct: 1895 ELYDFHEDLLLHCGVPLEEEEEEEEDTSWT--GKLCALVYKIKGPPKPEKEQPTEEEERC 1952
Query: 2055 SSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVE 2114
+TL++LIS+TM+ WAQE I+D ELVR MF LL RQYD IG L++AL KTYTI+ SV
Sbjct: 1953 PTTLKELISQTMICWAQEDQIQDSELVRMMFNLLRRQYDSIGELLQALRKTYTISHTSVS 2012
Query: 2115 DTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEV 2174
DTINLLA+LGQIRSLLSVRMGKEEE LMI GLGDIMNNKVFYQHPNLMR LGMHETVMEV
Sbjct: 2013 DTINLLAALGQIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEV 2072
Query: 2175 MVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAM 2234
MVNVLG E +I FPKMVA+CCRFLCYFCRISRQNQKAMF+HLSYLLENSSVGLASP+M
Sbjct: 2073 MVNVLGT-EKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSM 2131
Query: 2235 RGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVE 2294
RGSTPLDVAA+SVMDNNELAL+L EPDLEKVV YLAGCGLQSC ML++KGYPD+GWNP+E
Sbjct: 2132 RGSTPLDVAASSVMDNNELALSLEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIE 2191
Query: 2295 GERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIA 2354
GERYL FLRFAVF N ESVEENA+VVV+LLIRRPECFGPALRGEGGNGLLAAM+ AIKI+
Sbjct: 2192 GERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKIS 2251
Query: 2355 EDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKG 2414
E+P+ D PS + +EEE++ +HMGNAIM+FYSALIDLLGRCAPEMHLI GKG
Sbjct: 2252 ENPALDLPSQGYKREVSTGDDEEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKG 2311
Query: 2415 EAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDR 2474
EAIRIRSILRSL+P DLVG+ISI ++P++ KDG+V EPDM+A FCPDHKA MVLFLDR
Sbjct: 2312 EAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDR 2371
Query: 2475 VYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPL 2534
VYGI+ Q FLLHLLEVGFLPDLRA+ASLDT +LS T+ ALALNRY+C+AVLPLLTRCAPL
Sbjct: 2372 VYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRYICSAVLPLLTRCAPL 2431
Query: 2535 FAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVF 2594
FAGTEH SLIDS L T+YRLSKG SLTKAQRD+IE CLL+IC LRPSM+Q LLRRLVF
Sbjct: 2432 FAGTEHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVF 2491
Query: 2595 DVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQ 2654
DVP LNE+ KMPLKLLTNHYE+CWKYYCLP GWG++G A EEELHL+ KLFWGIFD+LS
Sbjct: 2492 DVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSH 2551
Query: 2655 KKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIP 2714
KKY+ +LF++ALPCLSA+AGALPPDY+++ + +EKQ S+D++GNF+P+P++T N ++P
Sbjct: 2552 KKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQISVDADGNFDPKPINTMNFSLP 2611
Query: 2715 EKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWP 2774
EKLEY + KYAEHSHDKW+ DK +GW YG ++ K PL++P+K L+EKEKEIYRWP
Sbjct: 2612 EKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWP 2671
Query: 2775 IKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLS 2834
+ESLKTMLA GW +ERT+EG+++ ++ SQ + + YSP +D+SNV LS
Sbjct: 2672 ARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQ--ANQGNSYSPAPLDLSNVVLS 2729
Query: 2835 RDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILK 2894
R+L M E++AENYHNIWAKKKK+ELESKGGG+HPLLVPYDTLTAKEK KDREKAQD+ K
Sbjct: 2730 RELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKFKDREKAQDLFK 2789
Query: 2895 FLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDG-GSRGKGEH 2953
FLQ+NG VSRG KD+ELD S+EKRFAY FL+++++YVD A ++I + S GK E
Sbjct: 2790 FLQVNGIIVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEK 2849
Query: 2954 FPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGV 3013
P +QEIKFFAKV+LPL+DQYF +H LYFLS+ +PL S G+AS+KEKEMV LFCKL
Sbjct: 2850 SPRDQEIKFFAKVLLPLVDQYFTSHCLYFLSSPLKPLSSSGYASHKEKEMVAGLFCKLAA 2909
Query: 3014 LVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTME 3073
LVRHRISLFG+D+T++V+CLHIL QTLD RTVMK+G E VK+ LRAF +NAAEDLEKT E
Sbjct: 2910 LVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSE 2969
Query: 3074 NLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRI 3133
NLK G+FTH+R Q KGV+Q INYTTVALLP+L+S+FEH+ QHQFG DL+L DVQ+SCY I
Sbjct: 2970 NLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVTQHQFGMDLLLGDVQISCYHI 3029
Query: 3134 LTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERA 3193
L SLY+LGT K+IYVERQR ALGECLA+ A A PVAFLE L+++N S++NTK+ RER+
Sbjct: 3030 LCSLYSLGTGKNIYVERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERS 3089
Query: 3194 ALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWEHG 3253
L +P VED+CP+IP LE LM+EI +LAESG RYT+MPHV+EVILPMLC+Y+S WWE G
Sbjct: 3090 ILGMPDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERG 3149
Query: 3254 PENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQ 3313
PEN P CCT + SEH++ +LGNILKII NNLGIDE +WMKR+AV++QPII+K +P
Sbjct: 3150 PENLPPSTGPCCTKVTSEHLSLILGNILKIINNNLGIDEASWMKRIAVYAQPIISKARPD 3209
Query: 3314 LLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLL 3373
LL++HF+P +EKLKKKA V EE+ LKA+ +GD EAELLILDEF L RDLYAFYP+L
Sbjct: 3210 LLRSHFIPTLEKLKKKAVKTVQEEEQLKADGKGDTQEAELLILDEFAVLCRDLYAFYPML 3269
Query: 3374 IRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLIT 3433
IR+VD NR+ WLK P+ ++++LFRMVAEVFI W KSHNFKREEQNFV+QNEINN++FL
Sbjct: 3270 IRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTG 3329
Query: 3434 DTKSKMSKA-----AVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQEL 3488
D+KSKMSKA DQERKK KR+GD YS+QTSLIVAALK++LPIGLN+C PGDQEL
Sbjct: 3330 DSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQEL 3389
Query: 3489 IALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDDTSDPEKTV 3548
I+LAK+R+S +DT++EVR+ +R+N+HLQ K +DPA++WQ+ LYKD+ ++++ +PEKTV
Sbjct: 3390 ISLAKSRYSHRDTDEEVREHLRNNLHLQEKSDDPAVKWQLNLYKDV-LKSEEPFNPEKTV 3448
Query: 3549 ERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPL 3608
ERV I+ +FHLEQ VE P RSKKAVWHKLLSKQRKRAVVACFRMAPL
Sbjct: 3449 ERVQRISAAVFHLEQ------------VEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPL 3496
Query: 3609 YNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAK-PGAEPPEEDEGTKRVDPLHQL 3667
YNLPRHR++NLFL GY++ WIETEE+ FE+KL++DLAK P E EE+E K+ DPLHQ+
Sbjct: 3497 YNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEETEKQPDPLHQI 3556
Query: 3668 ILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHD-EEDDDGEEEVKSFEEKEMEKQKLLY 3726
IL FSR ALTE+ KLE+D LY +Y+ +MAKSC E++++ E++ K+FEEKEMEKQK LY
Sbjct: 3557 ILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLY 3616
Query: 3727 QQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKD 3786
QQARLH+RGAAEMVLQ ISASKGE PMV TLKLGIAILNGGN+ VQQKMLDYLKEKKD
Sbjct: 3617 QQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKD 3676
Query: 3787 VGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGS------GEKVLQDDEFTCDLF 3840
GFFQSL+GLMQSCSVLDLNAFERQNKAEGLGMVTEEG+ GEKVLQ+DEFT DLF
Sbjct: 3677 AGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLF 3736
Query: 3841 RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE 3900
RFLQLLCEGHNSDFQN+LRTQ GN TTVN+IISTVDYLLR+QESISDFYWYYSGKD+IDE
Sbjct: 3737 RFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDE 3796
Query: 3901 QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ 3960
GQ NFSKA+ V KQ+FN+LTEYIQGPC GNQQSLAHSRLWDAVVGFLHVFA+MQMKLSQ
Sbjct: 3797 SGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQ 3856
Query: 3961 DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF 4020
DSSQIELLKEL+DL +DMVVMLLS+LEGNVVNGTIGKQMVD LVESS NVEMILKFFDMF
Sbjct: 3857 DSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMF 3916
Query: 4021 LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY 4080
LKLKDLTSSDTFKEYDPDGKG+ISK++F KAME K YTQSE +FLLSCAE DEN+ +Y
Sbjct: 3917 LKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNY 3976
Query: 4081 EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG 4140
+FV RFHEPAKDIGFNVAVLLTNLSEHMPND+RL+ L+ AESVLNYF+P+LGRIEIMG
Sbjct: 3977 VDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMG 4036
Query: 4141 SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM 4200
AK+IERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGE+EKMELFVNFCEDTIFEM
Sbjct: 4037 GAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEM 4096
Query: 4201 QLAAQISESDLNERSANKEESEKE--------RPEEQG---PRMAFFSILTVRSALFALR 4249
QLA+QISESD +R +EE E EE G P AF A +++
Sbjct: 4097 QLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSLEPASAF------AMACASVK 4150
Query: 4250 YNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRII 4309
N+ ++ +LK+L+KQ + VKKMT K++V FS +W +F+ L + ++ G F+I+
Sbjct: 4151 RNVTDFLKRATLKNLRKQYRNVKKMTAKELVKVLFSFFWMLFVGLFQLLFTILGGIFQIL 4210
Query: 4310 CSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGER-KPLEAALPSEDLTDLKE 4368
S + GG LVEGAK I+V ++L +MPDPTQ + D E ER + +E + +E + +K
Sbjct: 4211 WSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGITTELVHFIKG 4270
Query: 4369 LTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDL-----MSNPVPMPEVQEKFQEQK 4423
++D++SD+FGL K+EG + H P GL DL P + +K ++ +
Sbjct: 4271 EKGDTDIMSDLFGLHPKKEGS----LKHGPEVGLGDLSEIIGKDEPPTLESTVQKKRKAQ 4326
Query: 4424 AKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQ--------KLRQLHTHRYGEPEV 4475
A E + + E K E EKA+ EDGEKE+K KE++ + K ++ + +PE
Sbjct: 4327 AAEMKAANEAEGKVESEKADMEDGEKEDKDKEEEQAEYLWTEVTKKKKRRCGQKVEKPEA 4386
Query: 4476 PESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVVEGKELPT 4535
+ F+K + YQ KLL+Y ARNFYN+R LALFVAFAINFILLFYKV+ E P
Sbjct: 4387 FTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVT--------EEPL 4438
Query: 4536 RSSSENAK--VTSLDSSSHRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCL 4593
+E+ S + V +VL+ES+GYM PTLR LAI+HT+IS C++GYYCL
Sbjct: 4439 EEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCL 4498
Query: 4594 KVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKV 4653
KVPLV+FKREKE+ARKLEFDGLYITEQPSEDDIKGQWDRLVINT SFPNNYWDKFVKRKV
Sbjct: 4499 KVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKV 4558
Query: 4654 MDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVV 4713
++KYG+ YG +RI+ELLG+DK ALDFS E K + +SL + L+SID+KY +WKLGVV
Sbjct: 4559 INKYGDLYGAERIAELLGLDKNALDFSPVEETK--AEAASLVSWLSSIDMKYHIWKLGVV 4616
Query: 4714 FTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL 4773
FTDNSFLYLAWY TMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL
Sbjct: 4617 FTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL 4676
Query: 4774 LAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIED 4833
LAVVVYLYTVVAFNFFRKFYNKSED D PDMKCDDM+TCY+FHMYVGVRAGGGIGDEIED
Sbjct: 4677 LAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIED 4736
Query: 4834 PAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGI 4893
PAGD YE+YRI+FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQV+EDMETKCFICGI
Sbjct: 4737 PAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGI 4796
Query: 4894 GNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP 4953
GNDYFDT PHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCW+FFP
Sbjct: 4797 GNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFP 4856
Query: 4954 AGDCFRKQYEDQL 4966
AGDCFRKQYEDQL
Sbjct: 4857 AGDCFRKQYEDQL 4869
Score = 1956 bits (5068), Expect = 0.0
Identities = 920/1320 (69%), Positives = 1113/1320 (84%), Gaps = 24/1320 (1%)
Query: 1 MADGGEG-EDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVP 59
MA+GGEG EDEIQFLRT+DEVVLQC ATIHKEQ+K CLAAEG GNRLCFLE TS +K +P
Sbjct: 1 MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP 60
Query: 60 PDLSICTFVLEQSLSVRALQEMLANTVEKS-EGQVDVEKWKFMMKTAQGGGHRTLLYGHA 118
PDL +C FVLEQSLSVRALQEMLANT E EG AQGGGHRTLLYGHA
Sbjct: 61 PDLCVCNFVLEQSLSVRALQEMLANTGENGGEG------------AAQGGGHRTLLYGHA 108
Query: 119 ILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVG 178
+LLRHS+SGMYL CL+TSRS TDKLAFDVGL+E TGEACWWTIHPASKQRSEGEKVR+G
Sbjct: 109 VLLRHSFSGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIG 168
Query: 179 DDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLH 238
DDLILVSVSSERYLHLS NG++ VDA+F QTLW+V P SGS +GYL+GG V+RL H
Sbjct: 169 DDLILVSVSSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFH 228
Query: 239 GHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLR 298
GH DECLT+PS + + Q R + YE G ARSLWR+E LR++WSGS+IRWGQ FRLR
Sbjct: 229 GH-DECLTIPSTDQNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLR 287
Query: 299 HVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKE---KLDVGVRKEVDGMGTSEIK 355
H+TTG YL+L ED+ L+L D+ K+D KSTAF+FR+SKE KLD +++++GMG EIK
Sbjct: 288 HLTTGHYLALTEDQGLILQDRAKSDTKSTAFSFRASKELKEKLDSSHKRDIEGMGVPEIK 347
Query: 356 YGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRT 415
YGDSVC++QH+ +GLW+TY++ D K+ R+G ++RK I+H EGHMDDG++L R Q EES+
Sbjct: 348 YGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQA 407
Query: 416 ARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDK 475
AR+IR+T LF++F+ G A+ + LPIE V +LQDLI YF PP+E + HEDK
Sbjct: 408 ARIIRNTTALFSQFVSG-----NNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMRHEDK 462
Query: 476 QNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYE 535
QN+LR+LKNRQNLF+EEGM+ LVL CIDRL+VY+S AHFA +A E+G +WK ILN LY+
Sbjct: 463 QNKLRSLKNRQNLFKEEGMLALVLNCIDRLNVYNSVAHFAGIAREESGMAWKEILNLLYK 522
Query: 536 LLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIK 595
LLAALIRGNR NCAQFS +LDWLIS+L+RLE+SSGILEVLHC+L ESPEALN+I EGHIK
Sbjct: 523 LLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIK 582
Query: 596 SIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSM 655
SIISLLDKHGRNHKVLD+LCSLC+C+GVAVR+NQ+LICDNLLP R+LLLQTRL+N V+S+
Sbjct: 583 SIISLLDKHGRNHKVLDILCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSI 642
Query: 656 RPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGG 715
RPNIFLGV+EGSAQYKKWY+EL++D +PF+TAE THLRVGWAS+ GY+PYPGGGE WGG
Sbjct: 643 RPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGG 702
Query: 716 NGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPV 775
NGVGDDL+SYGFDGLHLWSG I R V+S NQHLLR+DDV+SCCLDL PSISFRINGQPV
Sbjct: 703 NGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPV 762
Query: 776 QGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVE 835
QGMFENFN DGLFFPV+SFSAG+KVRFL+GGRHGEFKFLPP GYAPCYEA+LPKEK+++E
Sbjct: 763 QGMFENFNTDGLFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLE 822
Query: 836 HSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVM 895
+EYK++ RDLLG T L+QA+F P PVDTSQ++LPPHLE+IR++LAENIHELW M
Sbjct: 823 PVKEYKRDADGIRDLLGTTQFLSQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGM 882
Query: 896 NKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDE 955
NKIELGW +G +RDDNKRQHPCLVEFSKLPE E+NYNLQMS ETLKTLLALGCH+ +
Sbjct: 883 NKIELGWTFGKIRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNP 942
Query: 956 HAEDKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQG 1015
AE+ +KK+KLPKNY +++GYKPAP+DLS +KL P QE +VDKLAENAHNVWA+DRI+QG
Sbjct: 943 AAEEDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQG 1002
Query: 1016 WTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARA 1075
WTYGIQQD+KN+RNPRLVPY LLD+RTKKSN+DSLREAVRT +GYGYN+E DQ+ A A
Sbjct: 1003 WTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADSA 1062
Query: 1076 EVCSGTGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAF 1135
V + ++ R FR E++YAV++G+WYFEFE VT GDMRVGW+RPGC+PD ELG+D++AF
Sbjct: 1063 -VEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAF 1121
Query: 1136 AFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDF 1195
F+G + QRWHQG+ ++GR+WQ GDVVGCM+++++ +M+FTLNGE+L+ + GSELAF D+
Sbjct: 1122 VFEGNRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADY 1181
Query: 1196 DVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRL 1255
++ +GF+P+C LG++Q+GRMN G D ST K++T+CGLQEG+EPFAVN NRD+ MW SKRL
Sbjct: 1182 EIENGFVPICCLGLSQIGRMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRL 1241
Query: 1256 PQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFS 1315
P F+ VP +H HIEV RIDGT+DS PCLKVT K+FG+QNSN D+++ RLSMP+EC FS
Sbjct: 1242 PTFVNVPKDHPHIEVMRIDGTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFS 1301
Score = 108 bits (271), Expect = 1e-22
Identities = 69/232 (29%), Positives = 116/232 (50%), Gaps = 20/232 (8%)
Query: 2697 SEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPL 2756
S+ +F P PVDTS + +P LE ++ AE+ H+ W M+K+ GW +G+I D+ + P
Sbjct: 845 SQASFIPCPVDTSQVILPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPC 904
Query: 2757 MKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVD 2816
+ + L E EK E+LKT+LA G I L + ++ + +S
Sbjct: 905 LVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDL--KKVKLPKNYMMS-- 960
Query: 2817 AAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKK---------KMELESKGGGN 2867
+GY P +D+S+V L + + +AEN HN+WAK + + +L++K
Sbjct: 961 --NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNK---R 1015
Query: 2868 HPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEK 2919
+P LVPY L + K +R+ ++ ++ GY + D EL ++EK
Sbjct: 1016 NPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEP--SDQELADSAVEK 1065
Score = 106 bits (264), Expect = 7e-22
Identities = 63/200 (31%), Positives = 105/200 (52%), Gaps = 10/200 (5%)
Query: 862 FTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEF 921
F P P++T LP LE I K AE+ H+ W +K + GW+YG D+N + HP + F
Sbjct: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657
Query: 922 SKLPEQERNYNLQMSLETLKTLLALGCHVGISDEH----AEDKVKKMKLPKNYQLTSGYK 977
L E+E+ + E+LKT+LA+G V + E + + +K++ + Y
Sbjct: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQANQGNSYS 2717
Query: 978 PAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTL 1037
PAP+DLS + L+ + MV+ +AEN HN+WA+ + + + G +P LVPY
Sbjct: 2718 PAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKG------GGSHPLLVPYDT 2771
Query: 1038 LDDRTKKSNKDSLREAVRTL 1057
L + K +++ ++ + L
Sbjct: 2772 LTAKEKFKDREKAQDLFKFL 2791
Score = 62.4 bits (150), Expect = 1e-08
Identities = 29/97 (29%), Positives = 53/97 (54%)
Query: 976 YKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPY 1035
+ P P++ L E +V K AE++H+ WA D+ + GW YGI D + +P + P+
Sbjct: 2598 FDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRPF 2657
Query: 1036 TLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHA 1072
L ++ K+ + RE+++T+L G+ +E + A
Sbjct: 2658 KTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEA 2694
Score = 41.2 bits (95), Expect = 0.026
Identities = 26/88 (29%), Positives = 44/88 (50%), Gaps = 8/88 (9%)
Query: 861 AFTPIPVDTSQIVLPPHLERIREKLAENIHELWV-MNKIELGWQYGPVRDDNKRQHPCLV 919
+++P P+D S +VL L+ + E +AEN H +W K+EL + G HP LV
Sbjct: 2715 SYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG-------GSHPLLV 2767
Query: 920 EFSKLPEQERNYNLQMSLETLKTLLALG 947
+ L +E+ + + + + K L G
Sbjct: 2768 PYDTLTAKEKFKDREKAQDLFKFLQVNG 2795
>gi|95147335 inositol 1,4,5-triphosphate receptor, type 2 [Homo
sapiens]
Length = 2701
Score = 164 bits (415), Expect = 2e-39
Identities = 92/288 (31%), Positives = 152/288 (52%), Gaps = 47/288 (16%)
Query: 4713 VFTDNSFLYLAWYMTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTV 4771
V D +FLY Y+ + +LG + + FF++ L D+ +TL ++ SVT NG+ ++LT
Sbjct: 2340 VILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTA 2399
Query: 4772 GLLAVVVYLYTVVAFNFFRKFYNKSEDG-------------------------------- 4799
L ++VYL++++ F F + + D
Sbjct: 2400 VLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGSHQVPTMTLTTMMEACAKENCSP 2459
Query: 4800 -------------DTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDE-YEIYRII 4845
D + CD +L C + + G+R GGG+GD + P+ DE R++
Sbjct: 2460 TIPASNTADEEYEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVV 2519
Query: 4846 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGF 4905
+D+ F+F VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 2520 YDLLFYFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSF 2579
Query: 4906 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP 4953
E H EHN+ +YL+F++ + KD TE+TG ESYV +M E+ ++FP
Sbjct: 2580 EEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMIVEKNLDWFP 2627
Score = 105 bits (261), Expect = 1e-21
Identities = 153/624 (24%), Positives = 261/624 (41%), Gaps = 88/624 (14%)
Query: 77 ALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTS 136
AL + L + E + Q + E K + + + Y + I L H S YL
Sbjct: 87 ALLKKLQHAAELEQKQNESENKKLLGEIVK--------YSNVIQLLHIKSNKYLTVNKRL 138
Query: 137 RSSTDKLAFDVGLQEDTTG-EACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLS 195
+ +K A V L D G E W+ IHP K RSEG+ + VGD ++L+ V++ + LH S
Sbjct: 139 PALLEKNAMRVSL--DAAGNEGSWFYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHAS 196
Query: 196 Y-----GNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSG 250
G V+A T W + S + L GGDV+RL H ++ LT
Sbjct: 197 NIELLDNPGCKEVNAVNCNTSWKITLFMKYSSYREDVLKGGDVVRLFHAEQEKFLT--CD 254
Query: 251 EHGEEQR---RTVHYEGGAVSVHARSLWRLETL-RVAWSGSHIRWGQPFRLRHVTTGKYL 306
E+ ++Q RT + + +++LW +E + G +W FR +H+ TG YL
Sbjct: 255 EYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYL 314
Query: 307 SLMEDKNLLLMDKEKADVKS----TAFTFRSSKEKL-----------DVGVRKEVDGMGT 351
+ + + E +V+ T+ R + EK+ D+ E+D
Sbjct: 315 AAELNPDYRDAQNEGKNVRDGVPPTSKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTL 374
Query: 352 SE---IKYGDSVCYIQHVDTGLWLTYQSVDVKS-------VRMGSIQRKAIMHHEGHMDD 401
+ +S ++H+ T W+T S+ + + +++G+ Q K +
Sbjct: 375 QRADCLVPRNSYVRLRHLCTNTWVTSTSIPIDTDEERPVMLKIGTCQTKEDKEAFAIVSV 434
Query: 402 GISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTV-DLPIESVSLSLQDLI 460
+S R + +V+ +TV KK + T+ V+ L+DLI
Sbjct: 435 PLSEVRDLDFANDANKVLATTV--------------KKLENGTITQNERRFVTKLLEDLI 480
Query: 461 GYF-HPPDEHLEHED----KQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFA 515
+ P+ E D K NR RQ L +E+ ++ V + + A +
Sbjct: 481 FFVADVPNNGQEVLDVVITKPNR-----ERQKLMREQNILAQVFGIL-KAPFKEKAGEGS 534
Query: 516 DVAGREAGES----WKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRL-ERLEASSG 570
+ + G+ +K +L Y +L + RKN + + + S++ + A
Sbjct: 535 MLRLEDLGDQRYAPYKYMLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDT 594
Query: 571 ILEVLH--CVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSN 628
I +LH L+E I I++ +SLL + R + LD L LCV + A+
Sbjct: 595 ITALLHNNRKLLEKH-----ITAKEIETFVSLL-RRNREPRFLDYLSDLCVSNTTAIPVT 648
Query: 629 QHLICDNLL-PGR-DLLLQTRLVN 650
Q LIC +L PG D+L+QT++V+
Sbjct: 649 QELICKFMLSPGNADILIQTKVVS 672
Score = 72.4 bits (176), Expect = 1e-11
Identities = 124/568 (21%), Positives = 211/568 (37%), Gaps = 157/568 (27%)
Query: 3713 SFEEKEMEKQKLLYQ--QARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGN 3770
SF ++ +K + Q L GA+E+V+ I +K + + + + LGIA+L GGN
Sbjct: 1729 SFSGQDSDKMGISMSDIQCLLDKEGASELVIDVIVNTKNDR--IFSEGIFLGIALLEGGN 1786
Query: 3771 STVQQKMLDYLKE-KKDVGFFQSLAGLMQSC-----SVLDLNAFERQNK----------- 3813
+ Q L E KK FF+ L M++ S + +N + NK
Sbjct: 1787 TQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGNKKRDDDNELMTS 1846
Query: 3814 -------------AEGL-GMVTE---------------------------------EGSG 3826
EG+ G +TE E S
Sbjct: 1847 GPRMRVRDSTLHLKEGMKGQLTEASSATSKAYCVYRREMDPEIDIMCTGPEAGNTEEKSA 1906
Query: 3827 EKVLQDDEFTC--DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQES 3884
E+V + RFLQLLCE HN + QN+LR Q N T N++ T+ +L + S
Sbjct: 1907 EEVTMSPAIAIMQPILRFLQLLCENHNRELQNFLRNQ-NNKTNYNLVCETLQFLDCICGS 1965
Query: 3885 ISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAV 3944
+ G ++ G K + + Q +LTEY QGPC NQ +A
Sbjct: 1966 TT------GGLGLL---GLYINEKNVALVNQNLESLTEYCQGPCHENQTCIA-------- 2008
Query: 3945 VGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLV 4004
+ +S+ I+++ + ++L N +N +GK +D+++
Sbjct: 2009 --------------THESNGIDII----------IALIL-----NDIN-PLGKYRMDLVL 2038
Query: 4005 ESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETE 4064
+ NN +L L ++ + + + + + R Y Q
Sbjct: 2039 QLKNNASKLL-----------LAIMESRHDSENAERILFNMRPRELVDVMKNAYNQG--- 2084
Query: 4065 FLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFL----- 4119
L C D+ D KD+G N+ +L L+ H + LQ L
Sbjct: 2085 --LECDHGDDEGGDD--------GVSPKDVGHNIYILAHQLARH---NKLLQQMLKPGSD 2131
Query: 4120 -ELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVN 4178
+ + L Y+ +IEI+ + +E++ F + + +ESK + +F+
Sbjct: 2132 PDEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNIC-----EYLTRESKCR-VFNTTE 2185
Query: 4179 EGGEKEKMELFVNFCEDTIFEMQLAAQI 4206
+ K+ F ED EM+ +I
Sbjct: 2186 RDEQGSKVNDFFQQTEDLYNEMKWQKKI 2213
Score = 33.1 bits (74), Expect = 7.1
Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 3/74 (4%)
Query: 2149 IMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISR 2208
+ N K QH L++ +G H V++++ E + +++ FL FCR +
Sbjct: 1194 VQNKKCRNQHQRLLKNMGAHSVVLDLLQIPY---EKNDEKMNEVMNLAHTFLQNFCRGNP 1250
Query: 2209 QNQKAMFDHLSYLL 2222
QNQ + HL+ L
Sbjct: 1251 QNQVLLHKHLNLFL 1264
>gi|153945846 inositol 1,4,5-triphosphate receptor, type 3 [Homo
sapiens]
Length = 2671
Score = 162 bits (410), Expect = 8e-39
Identities = 92/287 (32%), Positives = 152/287 (52%), Gaps = 49/287 (17%)
Query: 4716 DNSFLYLAWYMTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4774
D FLY Y+ SVLG + + F++ L D+ +TL ++ SVT NG+ ++LT L
Sbjct: 2317 DMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLA 2376
Query: 4775 AVVVYLYTVVAFNFFRKFY----------------------------------------- 4793
++VYL+++V F F + +
Sbjct: 2377 LILVYLFSIVGFLFLKDDFILEVDRLPNNHSTASPLGMPHGAAAFVDTCSGDKMDCVSGL 2436
Query: 4794 ------NKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEI-YRIIF 4846
+ + D+ + CD +L C + M G+R GGG+GD + P+ DE R+++
Sbjct: 2437 SVPEVLEEDRELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVY 2496
Query: 4847 DITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFE 4906
D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD FE
Sbjct: 2497 DLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFE 2556
Query: 4907 THTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP 4953
H EHN+ NYL+F++ + K++T++TG ESYV +M + + ++FP
Sbjct: 2557 EHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFP 2603
Score = 89.4 bits (220), Expect = 8e-17
Identities = 156/692 (22%), Positives = 264/692 (38%), Gaps = 96/692 (13%)
Query: 64 ICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAILLRH 123
I VL Q L A E N E + DV K YG I L H
Sbjct: 84 IADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVK-----------------YGSVIQLLH 126
Query: 124 SYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTG-EACWWTIHPASKQRSEGEKVRVGDDLI 182
S YL + +K A V L D TG E W I P K RS G+ V VGD +I
Sbjct: 127 MKSNKYLTVNKRLPALLEKNAMRVTL--DATGNEGSWLFIQPFWKLRSNGDNVVVGDKVI 184
Query: 183 LVSVSSERYLH-----LSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLL 237
L V++ + LH LS G V++ T W + + + L GGDV+RL
Sbjct: 185 LNPVNAGQPLHASNYELSDNAGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLF 244
Query: 238 HGHMDECLTVPSGEHGEEQ--RRTVHYEGGAVSVHARSLWRLETL-RVAWSGSHIRWGQP 294
H ++ LT + G+ Q RT + + + +LW +E + G W
Sbjct: 245 HAEQEKFLTCDEYK-GKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGL 303
Query: 295 FRLRHVTTGKYLSLMEDKNLL--LMDKEKADVKSTAFT-FRSSKEKL-----------DV 340
+R +H+ TG YL+ E+ + D + A + + T R++ EK+ D+
Sbjct: 304 YRFKHLATGNYLAAEENPSYKGDASDPKAAGMGAQGRTGRRNAGEKIKYCLVAVPHGNDI 363
Query: 341 GVRKEVDG---MGTSEIKYGDSVCYIQHVDTGLWL--TYQSVDVKSVR-----MGSIQRK 390
E+D T +S ++H+ T W+ T +D++ R +G+ K
Sbjct: 364 ASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNVPIDIEEERPIRLMLGTCPTK 423
Query: 391 AIMHHEGHMDDGISLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKASTVDLPIE 450
+ +S R + + ++ S V N +S+ + + L
Sbjct: 424 EDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNE-----GFISQNDRRFVIQL--- 475
Query: 451 SVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSS 510
L+DL+ + + ++ + + RQ L +E+ ++ V +
Sbjct: 476 -----LEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMREQNILKQVFGIL-------- 522
Query: 511 AAHFADVAGR-----------EAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLI 559
A F + G + ++ + Y +L RKN + +
Sbjct: 523 KAPFREKGGEGPLVRLEELSDQKNAPYQHMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQ 582
Query: 560 SRL-ERLEASSGILEVLH--CVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCS 616
S++ + A I +LH L+E I + +++ +SL+ K+ R + LD L
Sbjct: 583 SQIGYDILAEDTITALLHNNRKLLEKH-----ITKTEVETFVSLVRKN-REPRFLDYLSD 636
Query: 617 LCVCHGVAVRSNQHLICDNLLPGR--DLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWY 674
LCV + +A+ Q LIC +L + D+L++T L + + +L + + +
Sbjct: 637 LCVSNHIAIPVTQELICKCVLDPKNSDILIRTELRPVKEMAQSHEYLSIEYSEEEVWLTW 696
Query: 675 YELMVDHTEPFVTAEATHLRVGWASTEGYSPY 706
+ +H E V A R G A E Y
Sbjct: 697 TDKNNEHHEKSVRQLAQEARAGNAHDENVLSY 728
Score = 66.6 bits (161), Expect = 6e-10
Identities = 67/244 (27%), Positives = 105/244 (43%), Gaps = 51/244 (20%)
Query: 3728 QARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYL-KEKKD 3786
Q RL GA ++V I+++K E + ++ L I +L+GGN+ +Q+ + + +KK
Sbjct: 1725 QCRLDKEGATKLVCDLITSTKNEK--IFQESIGLAIHLLDGGNTEIQKSFHNLMMSDKKS 1782
Query: 3787 VGFFQSLAGLMQ----------SCSVLDLNAFERQNKAE--------------------- 3815
FF+ L M+ + ++ DL + +++
Sbjct: 1783 ERFFKVLHDRMKRAQQETKSTVAVNMNDLGSQPHEDREPVDPTTKGRVASFSIPGSSSRY 1842
Query: 3816 GLGMVTEEGS--GEKVLQDDEFTCDLF-----RFLQLLCEGHNSDFQNYLRTQTGNNTTV 3868
LG G E+V + T L RFLQLLCE HN D QN+LR Q N T
Sbjct: 1843 SLGPSLRRGHEVSERVQSSEMGTSVLIMQPILRFLQLLCENHNRDLQNFLRCQ-NNKTNY 1901
Query: 3869 NIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPC 3928
N++ T+ +L + S + G ++ G + + Q TLTEY QGPC
Sbjct: 1902 NLVCETLQFLDIMCGSTT------GGLGLL---GLYINEDNVGLVIQTLETLTEYCQGPC 1952
Query: 3929 TGNQ 3932
NQ
Sbjct: 1953 HENQ 1956
>gi|154354998 inositol 1,4,5-triphosphate receptor, type 1 isoform 1
[Homo sapiens]
Length = 2710
Score = 162 bits (409), Expect = 1e-38
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 50/288 (17%)
Query: 4716 DNSFLYLAWYMTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4774
D FLY Y+ + +G + + FF++ L D+ +TL ++ SVT NG+ ++LT L
Sbjct: 2349 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2408
Query: 4775 AVVVYLYTVVAFNFFRKFY--------------------------------NKSEDGDTP 4802
++VYL+++V + FF+ + E+ +P
Sbjct: 2409 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2468
Query: 4803 ----------------DMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDE-YEIYRII 4845
+ C+ +L C + + G+R+GGG+GD + P+ +E R+I
Sbjct: 2469 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2528
Query: 4846 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGF 4905
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 2529 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2588
Query: 4906 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP 4953
E H +EHN+ +YL F++ + KD TE+TG ESYV +M +ER ++FP
Sbjct: 2589 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2636
Score = 96.7 bits (239), Expect = 5e-19
Identities = 141/589 (23%), Positives = 238/589 (40%), Gaps = 88/589 (14%)
Query: 115 YGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEK 174
YG+ I L H S YL + +K A V L E E W+ I P K RS G+
Sbjct: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
Query: 175 VRVGDDLILVSVSSERYLHLSY-----GNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLI 229
V +GD ++L V++ + LH S G V++ T W + S+ L
Sbjct: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
Query: 230 GGDVLRLLHGHMDECLTVPSGEHGEEQR---RTVHYEGGAVSVHARSLWRLETLR-VAWS 285
GGDV+RL H ++ LT EH ++Q RT + + +++LW +E ++
Sbjct: 236 GGDVVRLFHAEQEKFLT--CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCR 293
Query: 286 GSHIRWGQPFRLRHVTTGKYLSL-----MEDKNLLLMDKEKADVKSTAFTFRSSKEKLDV 340
G W FR +H+ TG YL+ E++ L D ++ R+++EK+
Sbjct: 294 GGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVY 353
Query: 341 GVRKEVDGMGTSEI--------KYGDSV------CYIQHVDTGLWLTYQSVDVKSVRMGS 386
+ +G S I + GDS+ ++H+ T W V ++ +
Sbjct: 354 SLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTW-----VHSTNIPIDK 408
Query: 387 IQRKAIMHHEGHMDDGISLSRSQHEESRTARV----IRSTVFLFNRFIRGLDALSKKAKA 442
+ K +M + G S + E V +R F N + L +++ K +
Sbjct: 409 EEEKPVM-----LKIGTSPVKEDKEAFAIVPVSPAEVRDLDFA-NDASKVLGSIAGKLEK 462
Query: 443 STV-DLPIESVSLSLQDLIGYFHPPDEHLEHE------DKQNRLRALKNRQNLFQEEGMI 495
T+ SV+ L+DL+ YF + + K NR RQ L +E+ ++
Sbjct: 463 GTITQNERRSVTKLLEDLV-YFVTGGTNSGQDVLEVVFSKPNR-----ERQKLMREQNIL 516
Query: 496 NLVLECIDRLHVYSSAAHFADVA----------GREAGESWKSILNSLYELLAALIRGNR 545
+ + + A F D G + ++ I Y +L + R
Sbjct: 517 KQIFKLLQ--------APFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYR 568
Query: 546 KNCAQFSGSLDWLISRL-ERLEASSGILEVLH--CVLVESPEALNIIKEGHIKSIISLLD 602
KN + ++ ++ + A I +LH L+E I I + +SL+
Sbjct: 569 KNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKH-----ITAAEIDTFVSLVR 623
Query: 603 KHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLL--PGRDLLLQTRLV 649
K+ R + LD L LCV ++ Q LIC +L D+L++T+LV
Sbjct: 624 KN-REPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 671
Score = 72.0 bits (175), Expect = 1e-11
Identities = 107/494 (21%), Positives = 183/494 (37%), Gaps = 146/494 (29%)
Query: 3728 QARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKE-KKD 3786
Q L GA+ +V+ I + + + ++ L IA+L GGN+T+Q L E KK
Sbjct: 1756 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1813
Query: 3787 VGFFQ---------------------SLAGLMQSCSVLDLNAFERQNKAEGLGMVTEE-- 3823
FF+ S G + +D +A R+ E +TEE
Sbjct: 1814 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1873
Query: 3824 ----------------------------------GSGEKVLQDDEFTC------DLFRFL 3843
+ +K D E + + RFL
Sbjct: 1874 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1933
Query: 3844 QLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQ 3903
QLLCE HN D QN+LR Q N T N++ T+ +L + S + G ++ G
Sbjct: 1934 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1983
Query: 3904 RNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSS 3963
K + + Q +LTEY QGPC NQ +A + +S+
Sbjct: 1984 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2021
Query: 3964 QIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKL 4023
I+++ L+ N +N +GK+ +D+++E NN +L
Sbjct: 2022 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2056
Query: 4024 KDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEF 4083
L ++ + + + + + R K Y Q E EF E EN
Sbjct: 2057 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-----EDGENG------- 2102
Query: 4084 VKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLEL-----AESVLNYFQPFLGRIEI 4138
+ +++G N+ +L L+ H + LQ+ L+ + L ++ +IEI
Sbjct: 2103 -EDGAASPRNVGHNIYILAHQLARH---NKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2158
Query: 4139 MGSAKRIERVYFEI 4152
+ + +E++ F +
Sbjct: 2159 VRLDRTMEQIVFPV 2172
>gi|154354996 inositol 1,4,5-triphosphate receptor, type 1 isoform 2
[Homo sapiens]
Length = 2695
Score = 162 bits (409), Expect = 1e-38
Identities = 92/288 (31%), Positives = 154/288 (53%), Gaps = 50/288 (17%)
Query: 4716 DNSFLYLAWYMTMSVLGHY-NNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLL 4774
D FLY Y+ + +G + + FF++ L D+ +TL ++ SVT NG+ ++LT L
Sbjct: 2334 DVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLA 2393
Query: 4775 AVVVYLYTVVAFNFFRKFY--------------------------------NKSEDGDTP 4802
++VYL+++V + FF+ + E+ +P
Sbjct: 2394 LILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVESGENCSSP 2453
Query: 4803 ----------------DMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDE-YEIYRII 4845
+ C+ +L C + + G+R+GGG+GD + P+ +E R+I
Sbjct: 2454 APREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVI 2513
Query: 4846 FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGF 4905
+D+ FFF VI+I+L +I G+IID F +LR ++++ +E ++T CFICG+ D FD F
Sbjct: 2514 YDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTF 2573
Query: 4906 ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFP 4953
E H +EHN+ +YL F++ + KD TE+TG ESYV +M +ER ++FP
Sbjct: 2574 EEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFP 2621
Score = 95.1 bits (235), Expect = 2e-18
Identities = 138/577 (23%), Positives = 235/577 (40%), Gaps = 79/577 (13%)
Query: 115 YGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEK 174
YG+ I L H S YL + +K A V L E E W+ I P K RS G+
Sbjct: 117 YGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDE-AGNEGSWFYIQPFYKLRSIGDS 175
Query: 175 VRVGDDLILVSVSSERYLHLSY-----GNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLI 229
V +GD ++L V++ + LH S G V++ T W + S+ L
Sbjct: 176 VVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILK 235
Query: 230 GGDVLRLLHGHMDECLTVPSGEHGEEQR---RTVHYEGGAVSVHARSLWRLETLR-VAWS 285
GGDV+RL H ++ LT EH ++Q RT + + +++LW +E ++
Sbjct: 236 GGDVVRLFHAEQEKFLT--CDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCR 293
Query: 286 GSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKST----AFTFRSSKEKLDVG 341
G W FR +H+ TG YL+ D + D ++ +++ ++ S E D+
Sbjct: 294 GGAGYWNSLFRFKHLATGHYLAAEVDPD---QDASRSRLRNAQEKMVYSLVSVPEGNDIS 350
Query: 342 VRKEVDG---MGTSEIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGH 398
E+D G + +S ++H+ T W V ++ + + K +M
Sbjct: 351 SIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTW-----VHSTNIPIDKEEEKPVM----- 400
Query: 399 MDDGISLSRSQHEESRTARV----IRSTVFLFNRFIRGLDALSKKAKASTV-DLPIESVS 453
+ G S + E V +R F N + L +++ K + T+ SV+
Sbjct: 401 LKIGTSPVKEDKEAFAIVPVSPAEVRDLDFA-NDASKVLGSIAGKLEKGTITQNERRSVT 459
Query: 454 LSLQDLIGYFHPPDEHLEHE------DKQNRLRALKNRQNLFQEEGMINLVLECIDRLHV 507
L+DL+ YF + + K NR RQ L +E+ ++ + + +
Sbjct: 460 KLLEDLV-YFVTGGTNSGQDVLEVVFSKPNR-----ERQKLMREQNILKQIFKLLQ---- 509
Query: 508 YSSAAHFADVA----------GREAGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDW 557
A F D G + ++ I Y +L + RKN + +
Sbjct: 510 ----APFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGF 565
Query: 558 LISRL-ERLEASSGILEVLH--CVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVL 614
+ ++ + A I +LH L+E I I + +SL+ K+ R + LD L
Sbjct: 566 MQKQIGYDVLAEDTITALLHNNRKLLEKH-----ITAAEIDTFVSLVRKN-REPRFLDYL 619
Query: 615 CSLCVCHGVAVRSNQHLICDNLL--PGRDLLLQTRLV 649
LCV ++ Q LIC +L D+L++T+LV
Sbjct: 620 SDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLV 656
Score = 72.0 bits (175), Expect = 1e-11
Identities = 107/494 (21%), Positives = 183/494 (37%), Gaps = 146/494 (29%)
Query: 3728 QARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKE-KKD 3786
Q L GA+ +V+ I + + + ++ L IA+L GGN+T+Q L E KK
Sbjct: 1741 QCHLDKEGASNLVIDLIMNASSDR--VFHESILLAIALLEGGNTTIQHSFFCRLTEDKKS 1798
Query: 3787 VGFFQ---------------------SLAGLMQSCSVLDLNAFERQNKAEGLGMVTEE-- 3823
FF+ S G + +D +A R+ E +TEE
Sbjct: 1799 EKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVR 1858
Query: 3824 ----------------------------------GSGEKVLQDDEFTC------DLFRFL 3843
+ +K D E + + RFL
Sbjct: 1859 DQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMSAVITIMQPILRFL 1918
Query: 3844 QLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQ 3903
QLLCE HN D QN+LR Q N T N++ T+ +L + S + G ++ G
Sbjct: 1919 QLLCENHNRDLQNFLRCQ-NNKTNYNLVCETLQFLDCICGSTT------GGLGLL---GL 1968
Query: 3904 RNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSS 3963
K + + Q +LTEY QGPC NQ +A + +S+
Sbjct: 1969 YINEKNVALINQTLESLTEYCQGPCHENQNCIA----------------------THESN 2006
Query: 3964 QIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKL 4023
I+++ L+ N +N +GK+ +D+++E NN +L
Sbjct: 2007 GIDIITALI---------------LNDIN-PLGKKRMDLVLELKNNASKLL--------- 2041
Query: 4024 KDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEF 4083
L ++ + + + + + R K Y Q E EF E EN
Sbjct: 2042 --LAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEF-----EDGENG------- 2087
Query: 4084 VKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLEL-----AESVLNYFQPFLGRIEI 4138
+ +++G N+ +L L+ H + LQ+ L+ + L ++ +IEI
Sbjct: 2088 -EDGAASPRNVGHNIYILAHQLARH---NKELQSMLKPGGQVDGDEALEFYAKHTAQIEI 2143
Query: 4139 MGSAKRIERVYFEI 4152
+ + +E++ F +
Sbjct: 2144 VRLDRTMEQIVFPV 2157
>gi|37588869 ring finger protein 123 [Homo sapiens]
Length = 1314
Score = 82.4 bits (202), Expect = 1e-14
Identities = 40/128 (31%), Positives = 69/128 (53%), Gaps = 6/128 (4%)
Query: 1093 TYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQE--LGSDERAFAFDGFKAQRWHQGNE 1150
T V G+W +E + G M++GW C+ +QE +G ++A+DG + ++W+
Sbjct: 127 TTCVYKGKWLYEVLISSQGLMQIGWCTISCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTT 186
Query: 1151 HYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVA 1210
+YG++W AGD+V C++D+++ T+ F LNG L G+ +G + P SL
Sbjct: 187 NYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSL----GTAFENLSRGLGMAYFPAISLSFK 242
Query: 1211 QVGRMNFG 1218
+ NFG
Sbjct: 243 ESVAFNFG 250
Score = 50.4 bits (119), Expect = 4e-05
Identities = 59/211 (27%), Positives = 87/211 (41%), Gaps = 48/211 (22%)
Query: 672 KWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDG-- 729
KW YE+++ + +++GW + EE GVGD SY +DG
Sbjct: 134 KWLYEVLI--------SSQGLMQIGWCTISCRF----NQEE----GVGDTHNSYAYDGNR 177
Query: 730 LHLWSGCIARTVSSPNQ-HLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFN--IDG 786
+ W+ V++ N D++SC +DL ++SF +NG + FEN + +
Sbjct: 178 VRKWN------VTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLNGVSLGTAFENLSRGLGM 231
Query: 787 LFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAP-----------------CYEAVLPK 829
+FP +S S V F G R + P GY P C+ AVL
Sbjct: 232 AYFPAISLSFKESVAFNFGSRPLRY---PVAGYRPLQDPPSADLVRAQRLLGCFRAVLSV 288
Query: 830 EKLKVEHSREYKQERTYTRDLLGPTVSLTQA 860
E VE R +E + R PTV LT A
Sbjct: 289 ELDPVE-GRLLDKESSKWRLRGQPTVLLTLA 318
>gi|45387949 ring finger and SPRY domain containing 1 [Homo sapiens]
Length = 576
Score = 68.9 bits (167), Expect = 1e-10
Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 6/96 (6%)
Query: 1093 TYAVKAGRWYFEFETVTAGDMRVGWSRPGCQ----PDQELGSDERAFAFDGFKAQRWH-- 1146
T+ V AG WY+E VT+G M++GW+ + +G DE + A+DG + W+
Sbjct: 353 TFCVDAGVWYYEVTVVTSGVMQIGWATRDSKFLNHEGYGIGDDEYSCAYDGCRQLIWYNA 412
Query: 1147 QGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEIL 1182
+ H W+ GD VG ++D+NE M+F LNG L
Sbjct: 413 RSKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQL 448
Score = 40.8 bits (94), Expect = 0.034
Identities = 41/146 (28%), Positives = 64/146 (43%), Gaps = 22/146 (15%)
Query: 673 WYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHL 732
WYYE+ V VT+ +++GWA+ + G G+GDD +S +DG
Sbjct: 361 WYYEVTV------VTSGV--MQIGWATRDSKFL------NHEGYGIGDDEYSCAYDGCRQ 406
Query: 733 WSGCIARTVSSPNQH-LLRTDDVISCCLDLSAPSISFRINGQ--PVQGMFENFNIDGLFF 789
AR S P+ H + D + LDL+ + F +NG P + + + G FF
Sbjct: 407 LIWYNAR--SKPHIHPCWKEGDTVGFLLDLNEKQMIFFLNGNQLPPEKQVFSSTVSG-FF 463
Query: 790 PVVSFSAGIKVRFLLGGRHGEFKFLP 815
SF + + F G + FK+ P
Sbjct: 464 AAASFMSYQQCEFNFGAK--PFKYPP 487
>gi|4826686 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 [Homo sapiens]
Length = 740
Score = 57.8 bits (138), Expect = 3e-07
Identities = 46/191 (24%), Positives = 82/191 (42%), Gaps = 8/191 (4%)
Query: 1031 RLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAE-VCSGTGERFRIFR 1089
++V TL D + K K +++ L + N A ++ +C + E
Sbjct: 62 QIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHG 121
Query: 1090 AEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGN 1149
T + G+ Y+E G RVGWS Q +LG+D+ F F G + ++
Sbjct: 122 CRATKGLMKGKHYYEVSCHDQGLCRVGWST--MQASLDLGTDKFGFGFGGTGKKSHNKQF 179
Query: 1150 EHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGV 1209
++YG + D +GC +D+++ + F+ NG+ D G P C L
Sbjct: 180 DNYGEEFTMHDTIGCYLDIDKGHVKFSKNGK----DLGLAFEIPPHMKNQALFPACVLKN 235
Query: 1210 AQVGRMNFGKD 1220
A++ + NFG++
Sbjct: 236 AEL-KFNFGEE 245
>gi|157412282 ash2-like isoform b [Homo sapiens]
Length = 534
Score = 49.3 bits (116), Expect = 1e-04
Identities = 27/87 (31%), Positives = 47/87 (54%), Gaps = 10/87 (11%)
Query: 1093 TYAVKAGRWYFEFETVTAGDM------RVGWSRPGCQPDQELGSDERAFAFDGFKAQRWH 1146
++ V+ G WYFE +T +M R+GWS+P LG D+ ++++ K ++H
Sbjct: 319 SHGVRKGAWYFE---ITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFH 375
Query: 1147 QG-NEHYGRSWQAGDVVGCMVDMNEHT 1172
Q +HY + GDV+G +++ E T
Sbjct: 376 QSIGKHYSSGYGQGDVLGFYINLPEDT 402
>gi|157412280 ash2-like isoform a [Homo sapiens]
Length = 628
Score = 49.3 bits (116), Expect = 1e-04
Identities = 27/87 (31%), Positives = 47/87 (54%), Gaps = 10/87 (11%)
Query: 1093 TYAVKAGRWYFEFETVTAGDM------RVGWSRPGCQPDQELGSDERAFAFDGFKAQRWH 1146
++ V+ G WYFE +T +M R+GWS+P LG D+ ++++ K ++H
Sbjct: 413 SHGVRKGAWYFE---ITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFH 469
Query: 1147 QG-NEHYGRSWQAGDVVGCMVDMNEHT 1172
Q +HY + GDV+G +++ E T
Sbjct: 470 QSIGKHYSSGYGQGDVLGFYINLPEDT 496
>gi|39812378 RAN binding protein 9 [Homo sapiens]
Length = 729
Score = 45.4 bits (106), Expect = 0.001
Identities = 28/99 (28%), Positives = 47/99 (47%), Gaps = 5/99 (5%)
Query: 1089 RAEKTYAVKAGRWYFEFETVTAGD---MRVGWSRPGCQPDQELGSDERAFAFDGFKAQRW 1145
RA G +YFE + V+ G M +G S G ++ G D+ ++ + G +
Sbjct: 203 RATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSF 262
Query: 1146 HQGN--EHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEIL 1182
+ YG ++ GDV+GC V++ +T +T NG L
Sbjct: 263 CSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSL 301
>gi|209862789 microtubule associated monoxygenase, calponin and LIM
domain containing 3 isoform 1 [Homo sapiens]
Length = 2002
Score = 45.4 bits (106), Expect = 0.001
Identities = 45/183 (24%), Positives = 77/183 (42%), Gaps = 20/183 (10%)
Query: 4316 GSLVEGAKKIKVAELLANMPDPTQDE---VRGDGEEGERKPLEAALPSEDLTDLKELTEE 4372
GS V G ++ +A+ L P+ + E + E ++ E +L+ + + E
Sbjct: 869 GSGVNGLEEPSIAKRLRGTPERIELENYRLSLRQAEALQEVPEETQAEHNLSSVLDTGAE 928
Query: 4373 SDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEK--- 4429
D+ S +++ EG + + P P + L VP E K K EE+
Sbjct: 929 EDVASSSSESEMEEEGEEEEEEPRLPPSDLGG-----VPWKEAVRIHALLKGKSEEELEA 983
Query: 4430 --------EEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFW 4481
EE+EE + E E+ E ED ++EE+ + G Q+L+Q+ H E+ W
Sbjct: 984 SKSFGPGNEEEEEEEEEYEEEEEEDYDEEEEESSEAGNQRLQQV-MHAADPLEIQADVHW 1042
Query: 4482 KKI 4484
I
Sbjct: 1043 THI 1045
>gi|118601081 heterogeneous nuclear ribonucleoprotein U-like 2 [Homo
sapiens]
Length = 747
Score = 45.4 bits (106), Expect = 0.001
Identities = 33/105 (31%), Positives = 49/105 (46%), Gaps = 14/105 (13%)
Query: 1090 AEKTYAVKAGRWYFEFETVTAGDM----------RVGWSRPGCQPDQELGSDERAFAFDG 1139
A TY V G+ FE + M RVGWS +P +LG DE ++ FDG
Sbjct: 281 ARSTYGVTKGKVCFEAKVTQNLPMKEGCTEVSLLRVGWSVDFSRP--QLGEDEFSYGFDG 338
Query: 1140 FKAQRWHQGNEHYGRSWQAGDVVGCMV--DMNEHTMMFTLNGEIL 1182
+ + E +G+++ DV+GC + E + F+ NGE L
Sbjct: 339 RGLKAENGQFEEFGQTFGENDVIGCFANFETEEVELSFSKNGEDL 383
>gi|17975763 myelin transcription factor 1 [Homo sapiens]
Length = 1121
Score = 44.7 bits (104), Expect = 0.002
Identities = 22/64 (34%), Positives = 39/64 (60%)
Query: 4414 EVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEP 4473
E +E+ +E++ +EEE+EE+EE + E E+ E E+ E+EE+ +E+ + Q T
Sbjct: 264 EEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQ 323
Query: 4474 EVPE 4477
+ PE
Sbjct: 324 KAPE 327
Score = 42.0 bits (97), Expect = 0.015
Identities = 26/80 (32%), Positives = 46/80 (57%), Gaps = 6/80 (7%)
Query: 4405 LMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKL-- 4462
++S+ E +E+ +E++ EEE+EE+EE + E E+ E E+ E+EE+ +E++ +
Sbjct: 254 ILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIF 313
Query: 4463 --RQLHTHRYGEPEV--PES 4478
HT PE+ PES
Sbjct: 314 QEDTSHTSAQKAPELRGPES 333
Score = 41.2 bits (95), Expect = 0.026
Identities = 21/69 (30%), Positives = 42/69 (60%)
Query: 4393 LIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEK 4452
L P + S+ S + +E+ +E++ +EEE+EE EE + E E+ E E+ E+EE+
Sbjct: 235 LCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEE 294
Query: 4453 AKEDKGKQK 4461
+E++ +++
Sbjct: 295 EEEEEEEEE 303
Score = 36.6 bits (83), Expect = 0.64
Identities = 17/56 (30%), Positives = 33/56 (58%)
Query: 4425 KEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAF 4480
+EE++EE+EE + E E E E+ E+EE+ +E++ +++ + E P+ F
Sbjct: 258 EEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIF 313
Score = 35.4 bits (80), Expect = 1.4
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 3/70 (4%)
Query: 4417 EKFQEQK---AKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEP 4473
E+ +QK + EEE EE+EE + E E+ E E+ E+EE+ +E++ +++ + E
Sbjct: 246 EESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEE 305
Query: 4474 EVPESAFWKK 4483
E +++
Sbjct: 306 EAAPDVIFQE 315
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 44.3 bits (103), Expect = 0.003
Identities = 22/47 (46%), Positives = 34/47 (72%), Gaps = 3/47 (6%)
Query: 4416 QEKFQEQKAKEEE---KEEKEETKSEPEKAEGEDGEKEEKAKEDKGK 4459
+E+ +E++A EEE KEE EE K E E EGE+GE+ ++A+E++ K
Sbjct: 483 KEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKK 529
Score = 36.6 bits (83), Expect = 0.64
Identities = 32/117 (27%), Positives = 51/117 (43%), Gaps = 6/117 (5%)
Query: 4351 RKPLEAALPSEDLTDLKELTEESDLLSDIFGLDLKR--EGGQYKLIPHN-PNAGLSDLMS 4407
RK LE T + +T S +FG + Y + + P+ S +
Sbjct: 390 RKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQE 449
Query: 4408 NPVPMPEVQEKFQEQKAKEE---EKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQK 4461
+ + E E + ++AK+E E E +EE K + E E E E+EE AKE+ + K
Sbjct: 450 EQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAK 506
>gi|40538736 RAN binding protein 10 [Homo sapiens]
Length = 620
Score = 44.3 bits (103), Expect = 0.003
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 5/99 (5%)
Query: 1089 RAEKTYAVKAGRWYFEFETVTAGD---MRVGWSRPGCQPDQELGSDERAFAFDGFKAQRW 1145
RA G +YFE + V+ G M +G S G ++ G D+ ++ + G +
Sbjct: 91 RATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSF 150
Query: 1146 HQGN--EHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEIL 1182
+ YG ++ GDV+GC V++ T +T NG L
Sbjct: 151 CSSGTGQPYGPTFTTGDVIGCCVNLINGTCFYTKNGHSL 189
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 43.9 bits (102), Expect = 0.004
Identities = 20/51 (39%), Positives = 35/51 (68%)
Query: 4414 EVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQKLRQ 4464
E +E+ +E++ +EEE E+EE + E E+ E + EKEE+ K+ K K+K ++
Sbjct: 2247 EEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKE 2297
Score = 43.5 bits (101), Expect = 0.005
Identities = 19/47 (40%), Positives = 34/47 (72%)
Query: 4414 EVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQ 4460
E +E+ +E++ +EEE+E KEE + E ++ E E+ EK++K KE K ++
Sbjct: 2252 EEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEE 2298
Score = 38.5 bits (88), Expect = 0.17
Identities = 25/83 (30%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 4403 SDLMSNPVPMPEVQEKF--QEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKAKEDKGKQ 4460
S+ M + + E QE +E++ +EEE+E +EE E E+ E+ E EEK E + ++
Sbjct: 2227 SEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEE 2286
Query: 4461 KLRQLHTHRYGEPEVPESAFWKK 4483
K ++ + E + E F +K
Sbjct: 2287 KKKKKKEKKKEEVQEKEEVFEEK 2309
Score = 32.7 bits (73), Expect = 9.2
Identities = 23/79 (29%), Positives = 41/79 (51%), Gaps = 2/79 (2%)
Query: 4407 SNPVPMPEVQEKFQEQKAKEEEKEEKEETKS--EPEKAEGEDGEKEEKAKEDKGKQKLRQ 4464
S+ V E +E F E+ ++ EK+E+ S E E+ E E+ +EE+ +E++ ++K +
Sbjct: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEE 2273
Query: 4465 LHTHRYGEPEVPESAFWKK 4483
+ E E E KK
Sbjct: 2274 EGEEKQVEKEEEEKKKKKK 2292
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 43.9 bits (102), Expect = 0.004
Identities = 30/106 (28%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 4349 GERKPLEAALPSEDLT-DLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMS 4407
G + + +LP +D DL + E + LL+ + +R G + L+ P L+ +
Sbjct: 674 GLPRAVPLSLPYQDFKRDLSDYRERARLLNRV-----RRVGFSHMLLT-TPQVPLAPVQP 727
Query: 4408 NPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKA 4453
E +E+ ++++ +EE++EE+EE + E E+ E E+ E+EE A
Sbjct: 728 QANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEAA 773
Score = 42.7 bits (99), Expect = 0.009
Identities = 26/85 (30%), Positives = 51/85 (60%), Gaps = 6/85 (7%)
Query: 4383 DLKREGGQYK----LIPHNPNAGLSD-LMSNP-VPMPEVQEKFQEQKAKEEEKEEKEETK 4436
D KR+ Y+ L+ G S L++ P VP+ VQ + ++ +EEE+E++EE +
Sbjct: 687 DFKRDLSDYRERARLLNRVRRVGFSHMLLTTPQVPLAPVQPQANGKEEEEEEEEDEEEEE 746
Query: 4437 SEPEKAEGEDGEKEEKAKEDKGKQK 4461
+ E+ E E+ E+EE+ +E++ +++
Sbjct: 747 EDEEEEEEEEEEEEEEEEEEEEEEE 771
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [Homo
sapiens]
Length = 759
Score = 43.5 bits (101), Expect = 0.005
Identities = 34/139 (24%), Positives = 65/139 (46%), Gaps = 3/139 (2%)
Query: 4325 IKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTE-ESDLLSDIFGLD 4383
I + MP+ ++ + E + +D E +E E+ F
Sbjct: 79 INTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYK 138
Query: 4384 LKREGGQYKLIPHNPNA-GLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKA 4442
R+GG + + P A L ++ ++ E +EK +++K K+ + ++K E K++PEK
Sbjct: 139 SLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKK 198
Query: 4443 EGEDGEKEEKAKEDKGKQK 4461
+ + +KE+K KE+K K K
Sbjct: 199 K-KKKDKEKKKKEEKSKDK 216
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 43.5 bits (101), Expect = 0.005
Identities = 34/139 (24%), Positives = 65/139 (46%), Gaps = 3/139 (2%)
Query: 4325 IKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTE-ESDLLSDIFGLD 4383
I + MP+ ++ + E + +D E +E E+ F
Sbjct: 10 INTQQSFVTMPNVIVPDIEKEIRRMENGACSSFSEDDDSASTSEESENENPHARGSFSYK 69
Query: 4384 LKREGGQYKLIPHNPNA-GLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEKA 4442
R+GG + + P A L ++ ++ E +EK +++K K+ + ++K E K++PEK
Sbjct: 70 SLRKGGPSQREQYLPGAIALFNVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKK 129
Query: 4443 EGEDGEKEEKAKEDKGKQK 4461
+ + +KE+K KE+K K K
Sbjct: 130 K-KKKDKEKKKKEEKSKDK 147
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 43.5 bits (101), Expect = 0.005
Identities = 42/159 (26%), Positives = 71/159 (44%), Gaps = 21/159 (13%)
Query: 4324 KIKVAELLANMPDPTQDEVR-GDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGL 4382
K+K + + P P ++ GDG RKP++ +E EE DLLSD+ +
Sbjct: 213 KVKASHWSRSPPRPPRERFELGDG----RKPVK-----------EEKMEERDLLSDLQDI 257
Query: 4383 -DLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEK 4441
D +R+ + +G S+ E + E+ +EEE+EE+EE ++
Sbjct: 258 SDSERKTSSAESSSAESGSG-SEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 316
Query: 4442 AEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAF 4480
E + EE ++E+ + + R+ H VPES F
Sbjct: 317 EEASEQSAEEVSEEEMSEDEERENENHLL---VVPESRF 352
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 43.5 bits (101), Expect = 0.005
Identities = 42/159 (26%), Positives = 71/159 (44%), Gaps = 21/159 (13%)
Query: 4324 KIKVAELLANMPDPTQDEVR-GDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGL 4382
K+K + + P P ++ GDG RKP++ +E EE DLLSD+ +
Sbjct: 223 KVKASHWSRSPPRPPRERFELGDG----RKPVK-----------EEKMEERDLLSDLQDI 267
Query: 4383 -DLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEK 4441
D +R+ + +G S+ E + E+ +EEE+EE+EE ++
Sbjct: 268 SDSERKTSSAESSSAESGSG-SEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 326
Query: 4442 AEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAF 4480
E + EE ++E+ + + R+ H VPES F
Sbjct: 327 EEASEQSAEEVSEEEMSEDEERENENHLL---VVPESRF 362
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform 9
[Homo sapiens]
Length = 771
Score = 43.5 bits (101), Expect = 0.005
Identities = 42/159 (26%), Positives = 71/159 (44%), Gaps = 21/159 (13%)
Query: 4324 KIKVAELLANMPDPTQDEVR-GDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGL 4382
K+K + + P P ++ GDG RKP++ +E EE DLLSD+ +
Sbjct: 214 KVKASHWSRSPPRPPRERFELGDG----RKPVK-----------EEKMEERDLLSDLQDI 258
Query: 4383 -DLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEK 4441
D +R+ + +G S+ E + E+ +EEE+EE+EE ++
Sbjct: 259 SDSERKTSSAESSSAESGSG-SEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 317
Query: 4442 AEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAF 4480
E + EE ++E+ + + R+ H VPES F
Sbjct: 318 EEASEQSAEEVSEEEMSEDEERENENHLL---VVPESRF 353
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform 8
[Homo sapiens]
Length = 780
Score = 43.5 bits (101), Expect = 0.005
Identities = 42/159 (26%), Positives = 71/159 (44%), Gaps = 21/159 (13%)
Query: 4324 KIKVAELLANMPDPTQDEVR-GDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGL 4382
K+K + + P P ++ GDG RKP++ +E EE DLLSD+ +
Sbjct: 223 KVKASHWSRSPPRPPRERFELGDG----RKPVK-----------EEKMEERDLLSDLQDI 267
Query: 4383 -DLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEK 4441
D +R+ + +G S+ E + E+ +EEE+EE+EE ++
Sbjct: 268 SDSERKTSSAESSSAESGSG-SEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 326
Query: 4442 AEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAF 4480
E + EE ++E+ + + R+ H VPES F
Sbjct: 327 EEASEQSAEEVSEEEMSEDEERENENHLL---VVPESRF 362
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform 5
[Homo sapiens]
Length = 748
Score = 43.5 bits (101), Expect = 0.005
Identities = 42/159 (26%), Positives = 71/159 (44%), Gaps = 21/159 (13%)
Query: 4324 KIKVAELLANMPDPTQDEVR-GDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGL 4382
K+K + + P P ++ GDG RKP++ +E EE DLLSD+ +
Sbjct: 191 KVKASHWSRSPPRPPRERFELGDG----RKPVK-----------EEKMEERDLLSDLQDI 235
Query: 4383 -DLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEK 4441
D +R+ + +G S+ E + E+ +EEE+EE+EE ++
Sbjct: 236 SDSERKTSSAESSSAESGSG-SEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 294
Query: 4442 AEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAF 4480
E + EE ++E+ + + R+ H VPES F
Sbjct: 295 EEASEQSAEEVSEEEMSEDEERENENHLL---VVPESRF 330
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform 4
[Homo sapiens]
Length = 737
Score = 43.5 bits (101), Expect = 0.005
Identities = 42/159 (26%), Positives = 71/159 (44%), Gaps = 21/159 (13%)
Query: 4324 KIKVAELLANMPDPTQDEVR-GDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGL 4382
K+K + + P P ++ GDG RKP++ +E EE DLLSD+ +
Sbjct: 180 KVKASHWSRSPPRPPRERFELGDG----RKPVK-----------EEKMEERDLLSDLQDI 224
Query: 4383 -DLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEK 4441
D +R+ + +G S+ E + E+ +EEE+EE+EE ++
Sbjct: 225 SDSERKTSSAESSSAESGSG-SEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 283
Query: 4442 AEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAF 4480
E + EE ++E+ + + R+ H VPES F
Sbjct: 284 EEASEQSAEEVSEEEMSEDEERENENHLL---VVPESRF 319
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform 2
[Homo sapiens]
Length = 782
Score = 43.5 bits (101), Expect = 0.005
Identities = 42/159 (26%), Positives = 71/159 (44%), Gaps = 21/159 (13%)
Query: 4324 KIKVAELLANMPDPTQDEVR-GDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIFGL 4382
K+K + + P P ++ GDG RKP++ +E EE DLLSD+ +
Sbjct: 225 KVKASHWSRSPPRPPRERFELGDG----RKPVK-----------EEKMEERDLLSDLQDI 269
Query: 4383 -DLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPEK 4441
D +R+ + +G S+ E + E+ +EEE+EE+EE ++
Sbjct: 270 SDSERKTSSAESSSAESGSG-SEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 328
Query: 4442 AEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAF 4480
E + EE ++E+ + + R+ H VPES F
Sbjct: 329 EEASEQSAEEVSEEEMSEDEERENENHLL---VVPESRF 364
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 186,408,214
Number of Sequences: 37866
Number of extensions: 8531877
Number of successful extensions: 46231
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 204
Number of HSP's successfully gapped in prelim test: 206
Number of HSP's that attempted gapping in prelim test: 35235
Number of HSP's gapped (non-prelim): 7556
length of query: 4967
length of database: 18,247,518
effective HSP length: 124
effective length of query: 4843
effective length of database: 13,552,134
effective search space: 65632984962
effective search space used: 65632984962
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.