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Search of human proteins with 112789555
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112789555 ADAM metallopeptidase with thrombospondin type 1
motif, 19 preproprotein [Homo sapiens]
(1207 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 2568 0.0
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 1282 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 590 e-168
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 584 e-166
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 565 e-160
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 560 e-159
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 535 e-152
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 496 e-140
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 455 e-127
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 446 e-125
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 440 e-123
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 438 e-122
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 436 e-122
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 436 e-122
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 403 e-112
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 369 e-101
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 343 7e-94
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 340 6e-93
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 309 9e-84
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 282 1e-75
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 282 1e-75
gi|145309328 papilin [Homo sapiens] 281 2e-75
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 275 2e-73
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 273 6e-73
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 265 2e-70
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 259 1e-68
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 256 9e-68
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 251 4e-66
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 217 6e-56
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 185 3e-46
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 2568 bits (6656), Expect = 0.0
Identities = 1207/1207 (100%), Positives = 1207/1207 (100%)
Query: 1 MRLTHICCCCLLYQLGFLSNGIVSELQFAPDREEWEVVFPALWRREPVDPAGGSGGSADP 60
MRLTHICCCCLLYQLGFLSNGIVSELQFAPDREEWEVVFPALWRREPVDPAGGSGGSADP
Sbjct: 1 MRLTHICCCCLLYQLGFLSNGIVSELQFAPDREEWEVVFPALWRREPVDPAGGSGGSADP 60
Query: 61 GWVRGVGGGGSARAQAAGSSREVRSVAPVPLEEPVEGRSESRLRPPPPSEGEEDEELESQ 120
GWVRGVGGGGSARAQAAGSSREVRSVAPVPLEEPVEGRSESRLRPPPPSEGEEDEELESQ
Sbjct: 61 GWVRGVGGGGSARAQAAGSSREVRSVAPVPLEEPVEGRSESRLRPPPPSEGEEDEELESQ 120
Query: 121 ELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLL 180
ELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLL
Sbjct: 121 ELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLL 180
Query: 181 RRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCG 240
RRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCG
Sbjct: 181 RRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCG 240
Query: 241 GGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDK 300
GGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDK
Sbjct: 241 GGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDK 300
Query: 301 GRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNL 360
GRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNL
Sbjct: 301 GRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNL 360
Query: 361 FQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMST 420
FQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMST
Sbjct: 361 FQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMST 420
Query: 421 NWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTI 480
NWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTI
Sbjct: 421 NWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTI 480
Query: 481 AHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNC 540
AHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNC
Sbjct: 481 AHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNC 540
Query: 541 LLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKE 600
LLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKE
Sbjct: 541 LLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKE 600
Query: 601 CRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC 660
CRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC
Sbjct: 601 CRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC 660
Query: 661 PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEE 720
PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEE
Sbjct: 661 PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEE 720
Query: 721 KPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCG 780
KPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCG
Sbjct: 721 KPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCG 780
Query: 781 VCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSIN 840
VCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSIN
Sbjct: 781 VCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSIN 840
Query: 841 SDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIP 900
SDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIP
Sbjct: 841 SDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIP 900
Query: 901 SDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKY 960
SDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKY
Sbjct: 901 SDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKY 960
Query: 961 LTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC 1020
LTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC
Sbjct: 961 LTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC 1020
Query: 1021 IGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAE 1080
IGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAE
Sbjct: 1021 IGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAE 1080
Query: 1081 DCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHL 1140
DCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHL
Sbjct: 1081 DCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHL 1140
Query: 1141 QPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYA 1200
QPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYA
Sbjct: 1141 QPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYA 1200
Query: 1201 QKLQQKS 1207
QKLQQKS
Sbjct: 1201 QKLQQKS 1207
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 1282 bits (3317), Expect = 0.0
Identities = 592/1080 (54%), Positives = 761/1080 (70%), Gaps = 56/1080 (5%)
Query: 142 PPPPPQPPP-------SPPPAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVE 194
PP P P P +PP A A P +LL +PAF RDLYL LRRD RFL+ F VE
Sbjct: 51 PPLPAAPGPRRRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVE 110
Query: 195 QRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCG--GGLMGFIQLNED 252
+ A A + P CFY+G VL HPGSL S S CG GGL+G IQL ++
Sbjct: 111 E-----------AGAARRRGRPAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQE 159
Query: 253 FIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKIAESG 312
+ I+PLN++ + R+K S+ + ++ C ++++K +P + +
Sbjct: 160 QVLIQPLNNSQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDW 219
Query: 313 RGKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNL 372
R +R + +L E+ +ET+VVAD MV YHGA+AA+RFILT++NMV+N+FQH+SL +++N+
Sbjct: 220 RERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINI 279
Query: 373 RVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAA 432
+V KL+LL + P +L IGHHGE+ LESFC WQ+EE+G + +D VDAA
Sbjct: 280 QVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAA 339
Query: 433 ILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINH 492
+ +TR DFCVHKDEPCDTVGIAYL G+CS KRKC++AEDNGLNLAFTIAHE+GHN+G+NH
Sbjct: 340 VFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNH 399
Query: 493 DNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSV 552
D+DH SCA HIMSGEW+KG+N D+SWS CS++DLE FL+SK S CLL T+P+S ++V
Sbjct: 400 DDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTV 459
Query: 553 MVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGT 612
+P KLPGM Y+A+EQCQILFG A+FC+ M+H++C GLWC VEG+ C+TKLDPP+DGT
Sbjct: 460 RLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGT 519
Query: 613 DCDLGKWCKAGECTSRTSAPEHLAGEWS---LWSPCSRTCSAGISSRERKC--PGLDSEA 667
+C KWC+AGEC S+T PEH+ G+WS WS CSRTC G R+RKC P
Sbjct: 520 ECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGG 579
Query: 668 RDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFC 727
C G ++ +CEN PCP GLP FRD QCQA+ + K +L AV+ ++KPC L+C
Sbjct: 580 THCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLT--AVVVDDKPCELYC 637
Query: 728 SPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGK 787
SP+GKE P+L++++V+DGT CG D+C +G+CQK+GCDG++GS A+ED CGVC+G+GK
Sbjct: 638 SPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGK 697
Query: 788 SCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEH 847
+C ++KGDF+H RG AL+D+GK SINSDWKIE
Sbjct: 698 TCHLVKGDFSHARGT---------------------------ALKDSGKGSINSDWKIEL 730
Query: 848 SGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPEN 907
G F +AGTTV YVRRGLWEKISAKGPT PLHL+VLLF DQ+YG+HYEYT+P + EN
Sbjct: 731 PGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAEN 790
Query: 908 QSS--KAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPE 965
QS K + LF+WTH+ WE C CGGGER+T VSCT+I++K ++V++ C ++PE
Sbjct: 791 QSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPE 850
Query: 966 PQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKP 1025
PQ+R+CN PCQ+RW+ W+PCS TC KG Q R+V C QL NGT + R C GP+P
Sbjct: 851 PQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRP 910
Query: 1026 ASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDY 1085
A+ Q CEGQDC+++WEA WS+CS CGKG+ RTV CTN + KC STRPR E CEDY
Sbjct: 911 AAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTRPRAEEACEDY 970
Query: 1086 SKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNE 1145
S CY W+ GDWS CS TCGKG+QSRV+QCMHK+TGRHG+EC + KPA YR C+ + CN+
Sbjct: 971 SGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCND 1030
Query: 1146 KINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQKLQQ 1205
+IN NTITSPRLAALT+KC DQW VYCRVIREKNLCQDMRWYQRCC+TCRDFYA K++Q
Sbjct: 1031 RINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKMRQ 1090
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 590 bits (1521), Expect = e-168
Identities = 371/1079 (34%), Positives = 526/1079 (48%), Gaps = 93/1079 (8%)
Query: 164 EVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYT 223
++ ++ A+ + +L L + F++ F VE GP Q C YT
Sbjct: 84 KLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGP---------QWKHDFLDNCHYT 134
Query: 224 GAVL-RHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAIT-------GHPHRVYRQ 275
G + + + + S C G L G I ++ FIEPL +T + GHPH +Y++
Sbjct: 135 GYLQDQRSTTKVALSNCVG-LHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKK 193
Query: 276 KRSMEEKVTEKSALHSHYCGI--ISDKGRP----------RSRKIAESGRGKRYSYKLPQ 323
+ + + HSH CG+ + G+P S I + R +
Sbjct: 194 SALQQRHLYD----HSH-CGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSI 248
Query: 324 EYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHET 383
E +ET+VVAD MV YHG +IL+++N+V L++ SL VN+ V +LI+L E
Sbjct: 249 ERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTED 308
Query: 384 PPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVH 443
P L I HH +K L+SFCKWQ ++D +T + D A+LITR D C +
Sbjct: 309 QPNLEINHHADKSLDSFCKWQKSILSHQSD----GNTIPENGIAHHDNAVLITRYDICTY 364
Query: 444 KDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGL 503
K++PC T+G+A ++GMC +R C I ED GL AFTIAHE+GHN G+NHD SC
Sbjct: 365 KNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKG 424
Query: 504 H----IMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLP 559
H +M+ N SWS CS++ + FL S CL P+ + P+ P
Sbjct: 425 HEAAKLMAAHIT--ANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPK--RDFLYPAVAP 480
Query: 560 GMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGK- 618
G Y ADEQC+ +G + C+ + +C LWC + C T P +GT C G
Sbjct: 481 GQVYDADEQCRFQYGATSRQCKYGE--VCRELWC-LSKSNRCVTNSIPAAEGTLCQTGNI 537
Query: 619 ---WCKAGECTSRTSAPEHLA---GEWSLWSPCSRTCSAGISSRERKC--PGLDSEARDC 670
WC G+C + P+ + G WSLW CSRTC G+SS R C P + C
Sbjct: 538 EKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYC 597
Query: 671 NGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPV 730
G RK+YR C PCP G FR+ QC + K+ KPCAL C
Sbjct: 598 LGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAE 657
Query: 731 GKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCK 790
G + V+DGT C LDIC NG C+ VGCD +LGS ARED C VC G+G +C
Sbjct: 658 GYNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCD 717
Query: 791 IIKGDFNHT--RGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQ-SINSDWKIEH 847
I+G FN + RG GY+EV+ IP G+ I+V E + +Y+AL+ G IN W I+
Sbjct: 718 AIEGFFNDSLPRG-GYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDW 776
Query: 848 SGAFNLAGTTVHYVR-RGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPE 906
F++AGT HY R E + A GPT+ L ++VLL Q+QN G+ Y++ +P
Sbjct: 777 PRKFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLL-QEQNLGIRYKFNVPI----T 831
Query: 907 NQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEP 966
S E F W H W +C ATC GG ++ V C ++ + SIV N C +KP
Sbjct: 832 RTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRL--DDNSIVQNNYCDPDSKPPE 889
Query: 967 QIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPA 1026
R CN +PC W + +W CS+TC GM++R V C +++ C+ +P
Sbjct: 890 NQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPV 949
Query: 1027 SAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC-------TNPRKKCVLSTRPREA 1079
+ C Q C W A WSEC+ KCG G +HR V C T P +C ++P
Sbjct: 950 EKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVR 1009
Query: 1080 EDCEDYSKCYV--WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRP 1137
C +C W GDW +CS CG G Q R +QC+ TG+ ++C + RP
Sbjct: 1010 IRC-SLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCL-SYTGQASSDCLET-----VRP 1062
Query: 1138 CHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCR 1196
+Q C K + I++ T +C YC ++ + C + Q CC+TC+
Sbjct: 1063 PSMQQCESKCDSTPISN------TEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQ 1115
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 584 bits (1505), Expect = e-166
Identities = 349/920 (37%), Positives = 482/920 (52%), Gaps = 65/920 (7%)
Query: 174 RDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVL--RHPG 231
R+L L + LAP F E R G G A PA C G V G
Sbjct: 89 RELRFNLTANQHLLAPGFVSETRRRGGLGR--AHIRAHTPA-----CHLLGEVQDPELEG 141
Query: 232 SLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITGH--PHRVYRQKRSMEEKVTEKSAL 289
LA+ S C G L G QL+ + FIEPL+ A GH PH VY KR E++ ++
Sbjct: 142 GLAAISACDG-LKGVFQLSNEDYFIEPLDSAPARPGHAQPHVVY--KRQAPERLAQRGDS 198
Query: 290 HS-HYCGII------SDKGRPRSRKIAESGRGKR-YSYKLPQEYNIETVVVADPAMVSYH 341
+ CG+ S + R R+ R +R + + +E +ET+VVAD MV YH
Sbjct: 199 SAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYH 258
Query: 342 GADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFC 401
G ++LTI+NMV LF S+ +++ +++L+LL + +L I HH + L+SFC
Sbjct: 259 GQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFC 318
Query: 402 KWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCS 461
KWQ + K D H D AIL+TRKD C + PC+T+G+++++GMC
Sbjct: 319 KWQ-KSINMKGDAH----------PLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQ 367
Query: 462 EKRKCIIAEDNGLNLAFTIAHEMGHNMGINHD---NDHPSCADGLHIMSGEWIKGQNLGD 518
R C I ED GL LAFT+AHE+GH+ GI HD ND IMS + + +
Sbjct: 368 PHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLL--YDAAP 425
Query: 519 VSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLAS 578
++WSRCS++ + RFL CL +P + + + PS PG+ Y QC++ +G ++
Sbjct: 426 LTWSRCSRQYITRFLDRGWGLCL--DDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSA 483
Query: 579 FCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGE 638
FC++M +V C LWC V C +KLD +DGT C KWC +GEC PE + G
Sbjct: 484 FCEDMDNV-CHTLWCSVG--TTCHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGG 540
Query: 639 WS---LWSPCSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGLPGFR 693
WS WS CSR+C G+ S ER+C P + R C G RK++R+C CPAG P FR
Sbjct: 541 WSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFR 600
Query: 694 DWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQ-- 751
QC + + + W V+++ PC L C P + L + V+DGT C YQ
Sbjct: 601 HVQCSHFDAMLYKGQ-LHTWVPVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPC-YQVR 658
Query: 752 -GLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVI 810
D+C NG C+ VGCD + S A ED CGVC+GNG +C + G F G GYV+V +I
Sbjct: 659 ASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLI 718
Query: 811 PAGARRIKVVEEKPAHSYLALR--DAGKQSINSDWKIEHSGAFNLAGTTVHYVRRGLWEK 868
PAGAR I++ E A ++LALR D K +N W I+ +G + +AGTT Y RRG WE
Sbjct: 719 PAGAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWEN 778
Query: 869 ISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCD 928
+++ GPT P+ + LLFQ+ N G+HYEYTI + + P P+F W + W C
Sbjct: 779 LTSPGPTKEPV-WIQLLFQESNPGVHYEYTIHRE---AGGHDEVPPPVFSWHYGPWTKCT 834
Query: 929 ATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPC 988
TCG G ++ V C + + VD E C L +P+ Q RKC+EQPC RW EW C
Sbjct: 835 VTCGRGVQRQNVYC---LERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLC 891
Query: 989 SRTCGK-GMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQ-DCMTVWEAGVW 1045
S +CG G+ R V C + + C P+P + C C W G W
Sbjct: 892 SSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNW 951
Query: 1046 SECSVKCGKGIRHRTVRCTN 1065
S+CSV CG+G + R V CTN
Sbjct: 952 SQCSVTCGEGTQRRNVLCTN 971
Score = 131 bits (329), Expect = 4e-30
Identities = 91/302 (30%), Positives = 129/302 (42%), Gaps = 43/302 (14%)
Query: 900 PSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCK 959
P+DPL + W +W +C TCG G V C S +E C
Sbjct: 1404 PADPLVVRNAG--------WQAGNWSECSTTCGLGAVWRPVRC--------SSGRDEDCA 1447
Query: 960 YLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERD 1019
+P+P R+C+ +PC T W W+ CSR+CG G R V C + L R
Sbjct: 1448 PAGRPQPA-RRCHLRPCAT-WHSGNWSKCSRSCGGGSSVRDVQC---VDTRDLRPLRPFH 1502
Query: 1020 CI-GP-KPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPR 1077
C GP KP + + C Q C++ W W ECS CG G + R V C P C + RP
Sbjct: 1503 CQPGPAKPPAHRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPEPGL-CEEALRPN 1560
Query: 1078 EAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITG---RHGNECFSSEKPAA 1134
C + C W +G W +CS CG G+Q R+++C++ TG ++C P +
Sbjct: 1561 TTRPCNTHP-CTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPES 1619
Query: 1135 YRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPV-YCRVIREKNLCQDMRWYQRCCE 1193
RPC + C + PR C D+ +C +R CQ +CC
Sbjct: 1620 SRPCGTEDC------EPVEPPR-------CERDRLSFGFCETLRLLGRCQLPTIRTQCCR 1666
Query: 1194 TC 1195
+C
Sbjct: 1667 SC 1668
Score = 93.6 bits (231), Expect = 1e-18
Identities = 54/176 (30%), Positives = 77/176 (43%), Gaps = 18/176 (10%)
Query: 980 WMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTV 1039
W WT C+ TCG+G+Q + V C ++ + + D +G ++C Q C
Sbjct: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGP--VDEEHCDPLGRPDDQQRKCSEQPCPAR 882
Query: 1040 WEAGVWSECSVKCGKG-IRHRTVRCTNP----------RKKCVLSTRPREAEDCEDYSKC 1088
W AG W CS CG G + R V C C RP C + C
Sbjct: 883 WWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPC 942
Query: 1089 -YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
W +G+WS+CS+TCG+G Q R + C T G C +++PA+ C L C
Sbjct: 943 PATWAVGNWSQCSVTCGEGTQRRNVLC----TNDTGVPCDEAQQPASEVTCSLPLC 994
Score = 45.4 bits (106), Expect = 3e-04
Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 1089 YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE-CFSSEKP-AAYRPCHLQPC 1143
+ W G W+KC++TCG+G+Q + + C+ + G E C +P R C QPC
Sbjct: 823 FSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPC 879
Score = 41.6 bits (96), Expect = 0.005
Identities = 29/110 (26%), Positives = 47/110 (42%), Gaps = 12/110 (10%)
Query: 1096 WSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNE-KINVNTITS 1154
WS CS +CG G+QS QC G C K +R C+LQ C + + +
Sbjct: 547 WSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERK--RFRLCNLQACPAGRPSFRHVQC 604
Query: 1155 PRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQKLQ 1204
A+ +K Q + V+ + N C + C +++A+KL+
Sbjct: 605 SHFDAMLYK---GQLHTWVPVVNDVNPC------ELHCRPANEYFAEKLR 645
Score = 32.0 bits (71), Expect = 3.7
Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 10/70 (14%)
Query: 94 PVEGRSESRLRPPPPSEGEEDEELESQELPRGSSGAAALSPGAPASWQPPPPPQPPPSPP 153
PV S+S+L PPP +E + E P+G GAP P PP SP
Sbjct: 1197 PVGKDSQSQL--PPPWRDRTNEVFKDDEEPKGR--------GAPHLPPRPSSTLPPLSPV 1246
Query: 154 PAQHAEPDGD 163
+ H+ P D
Sbjct: 1247 GSTHSSPSPD 1256
Score = 30.8 bits (68), Expect = 8.1
Identities = 42/163 (25%), Positives = 58/163 (35%), Gaps = 20/163 (12%)
Query: 87 APVPLEEPVEGRSESRL--------------RPPPPSEGEEDEELESQELPRGSSGAAAL 132
+PVP EP + E L PPPPSE L LP + A
Sbjct: 1109 SPVPATEPPAAKEEGVLGPWSPSPWPSQAGRSPPPPSEQTPGNPL-INFLPEEDTPIGAP 1167
Query: 133 SPGAPA-SW-QPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPR 190
G P+ SW + P+ P +Q+ P G + ++P RD + +D R
Sbjct: 1168 DLGLPSLSWPRVSTDGLQTPATPESQNDFPVGKDSQSQLPPPWRDRTNEVFKDDEEPKGR 1227
Query: 191 FAVEQRPNPG---PGPTGAASAPQPPAPPDAGCFYTGAVLRHP 230
A P P P + S P+P A + G V P
Sbjct: 1228 GAPHLPPRPSSTLPPLSPVGSTHSSPSPDVAELWTGGTVAWEP 1270
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 565 bits (1455), Expect = e-160
Identities = 371/1129 (32%), Positives = 536/1129 (47%), Gaps = 140/1129 (12%)
Query: 119 SQELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQH-------AEPDGDEVL----- 166
+++ P + G AA +PG+P+ +PPPP + P ++ + GD V
Sbjct: 22 AEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDHRGDYVSHEIMH 81
Query: 167 -----------------LRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASA 209
LR+ D ++ LR +AP F V+ G TG S
Sbjct: 82 HQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTL-----GKTGTKSV 136
Query: 210 PQPPAPPDAGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAI---- 265
PP+ CFY G++ H S + STC GL G I+ E F+ PL ++
Sbjct: 137 QT--LPPEDFCFYQGSLRSHRNSSVALSTC-QGLSGMIRTEEADYFLRPLPSHLSWKLGR 193
Query: 266 ----TGHPHRVYRQKR------SMEEKVTEKSALHSHYCGIISDKGRPRSRKIAESGRGK 315
+ H +Y++ + E VT ++ +H SD +K GR K
Sbjct: 194 AAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRK 253
Query: 316 RYS--------YKLPQEY-------------------NIETVVVADPAMVSYHGADAARR 348
+Y + LP EY N+ET+VV D M+ HG +
Sbjct: 254 KYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITT 313
Query: 349 FILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEF 408
++LTILNMV LF+ ++ +N+ ++ LILL + P L I HH + L SFC+WQ
Sbjct: 314 YVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQ---- 369
Query: 409 GKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCII 468
S G+D T D AIL+T D C K+EPCDT+G A +SGMCS+ R C I
Sbjct: 370 ----------SGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTI 419
Query: 469 AEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKED 528
ED GL LAFTIAHE GHN G+ HD + C + + G+N G SWS CS++
Sbjct: 420 NEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRN-GVFSWSPCSRQY 478
Query: 529 LERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQ-EMQHVI 587
L +FL + + CL P+ V P KLPG Y A+ QC+ FG A C + + I
Sbjct: 479 LHKFLSTAQAICLAD-QPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDI 537
Query: 588 CTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTS-RTSAPEHLAG---EWSLWS 643
C LWC G K C TK P +GT C WC+ G+C P+ G +WS WS
Sbjct: 538 CKALWCHRIGRK-CETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWS 596
Query: 644 PCSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYS 701
PCSRTC G+S R R C P + C G + ++C + CP FR QC ++
Sbjct: 597 PCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHN 656
Query: 702 VRTSSPKHILQWQ--AVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANG 759
R +H +W+ ++++ C L+C G + LS KV DGT C ++C +G
Sbjct: 657 SRRFRGRH-YKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDG 715
Query: 760 RCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDF-NHTRGAGYVEVLVIPAGARRIK 818
C++VGCD +LGS A ED CGVCNGN +C I +G + H Y ++ IP+GAR I+
Sbjct: 716 ICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIR 775
Query: 819 VVEEKPAHSYLALRDA-GKQSINSDWKIEHSGAFNLAGTTVHYVRR-GLWEKISAKGPTT 876
+ E + SY+++R+A + +N W ++ G + +GTT Y R E + A GPT
Sbjct: 776 IYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTN 835
Query: 877 APLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGER 936
L ++ LLFQ +N G+ +EY++P + +P + W +C +CGGG+
Sbjct: 836 ETL-IVELLFQGRNPGVAWEYSMPR---LGTEKQPPAQPSYTWAIVR-SECSVSCGGGQM 890
Query: 937 KTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGM 996
C + + +++ C T+P + C C W + W+ CSRTCG G
Sbjct: 891 TVREGCYRDLKFQVNM---SFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGA 947
Query: 997 QSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGI 1056
QSR V CT+++ + C P P+S Q C Q C W AG W+ECS CGKG
Sbjct: 948 QSRPVQCTRRVHYDS-EPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGW 1006
Query: 1057 RHRTVRC--TNPRKK--------CVLSTRPREAEDCEDYSKCY-----VWRMGDWSKCSI 1101
R R V C TNP + C +PR E C +C+ W + WS+CS+
Sbjct: 1007 RKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACL-LQRCHKPKKLQWLVSAWSQCSV 1065
Query: 1102 TCGKGMQSRVIQCMHK-ITGRH----GNECFSSEKPA--AYRPCHLQPC 1143
TC +G Q R ++C K ++G++ +C KP+ R C PC
Sbjct: 1066 TCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPC 1114
Score = 124 bits (312), Expect = 4e-28
Identities = 85/309 (27%), Positives = 124/309 (40%), Gaps = 52/309 (16%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRK-CNEQPCQ 977
W+ +W C TCGGG + V CT+ + + V C +P P R+ CN Q C
Sbjct: 931 WSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCP---QPAPSSRQACNSQSCP 987
Query: 978 TRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQDC 1036
W W CS TCGKG + R VAC + + C PKP + C Q C
Sbjct: 988 PAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRC 1047
Query: 1037 ----MTVWEAGVWSECSVKCGKGIRHRTVRCTNP----------RKKCVLSTRPR-EAED 1081
W WS+CSV C +G + R ++C KKC +P E E
Sbjct: 1048 HKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
Query: 1082 CEDYSKCY-------------VWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFS 1128
C W WS+C+ +CG G+Q+R +QC+ GR + C
Sbjct: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL--AGGRPASGCLL 1165
Query: 1129 SEKPAAYRPC--HLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMR 1186
+KP+A C H P EK + + +C ++ + +C
Sbjct: 1166 HQKPSASLACNTHFCPIAEKKD---------------AFCKDYFHWCYLVPQHGMCSHKF 1210
Query: 1187 WYQRCCETC 1195
+ ++CC+TC
Sbjct: 1211 YGKQCCKTC 1219
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 560 bits (1442), Expect = e-159
Identities = 358/958 (37%), Positives = 495/958 (51%), Gaps = 87/958 (9%)
Query: 161 DGDE--VLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQR-PNPGPGPTGAASAPQPPAPPD 217
DG E V RI +DL+ L + FL+ + +E+R N A+SAP
Sbjct: 85 DGSEDWVYYRISHEEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPL------ 138
Query: 218 AGCFYTGAVLRHPGSL--ASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITG--HPHRVY 273
C +G VL+ + A+ S C G L GF QL FIEP+ + G HPH VY
Sbjct: 139 --CHLSGTVLQQGTRVGTAALSACHG-LTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVY 195
Query: 274 RQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKIAESGRGKRYSYKLP----------Q 323
R+++ E K CG+ K + E R K + LP +
Sbjct: 196 RRQKVPETKEPT--------CGL---KDSVNISQKQELWREKWERHNLPSRSLSRRSISK 244
Query: 324 EYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHET 383
E +ET+VVAD M+ YHG++ +ILTI+NMV LF + S+ +++ V++LILL E
Sbjct: 245 ERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEE 304
Query: 384 PPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSV--DAAILITRKDFC 441
L I HH EK L SFCKWQ S N D+ V D A+L+TRKD C
Sbjct: 305 EQGLKIVHHAEKTLSSFCKWQK-------------SINPKSDLNPVHHDVAVLLTRKDIC 351
Query: 442 VHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCAD 501
+ PC+T+G+++LSGMC R C I ED+GL LAFTIAHE+GH+ GI HD C
Sbjct: 352 AGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEP 411
Query: 502 -GLH--IMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQ-TNPQSVNSVMVPSK 557
G H IMS + + ++WS+CS+E + RFL CL + + S ++
Sbjct: 412 VGRHPYIMSRQ--LQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVI--- 466
Query: 558 LPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLG 617
PG+ Y QCQ+ +GP A+FCQE+++V C LWC V+G CR+KLD DGT C
Sbjct: 467 APGVIYDVHHQCQLQYGPNATFCQEVENV-CQTLWCSVKG--FCRSKLDAAADGTQCGEK 523
Query: 618 KWCKAGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNG 672
KWC AG+C + PE + G W WSP CSRTC AG+ S ER C P + C G
Sbjct: 524 KWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTG 583
Query: 673 PRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGK 732
RK+YR+C PC + P FR QC + + W + + PC L+C P+
Sbjct: 584 ERKRYRLCNVHPCRSEAPTFRQMQCSEFDT-VPYKNELYHWFPIFNPAHPCELYCRPIDG 642
Query: 733 EQPILLSEKVMDGTSC--GYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCK 790
+ + + V+DGT C G ++C NG C+ VGCD + S A ED CGVC G+G SC+
Sbjct: 643 QFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQ 702
Query: 791 IIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALR--DAGKQSINSDWKIEHS 848
++ F G+GYV++ +IP GAR I+V+E + A ++LA+R D K +N + I+ +
Sbjct: 703 TVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWN 762
Query: 849 GAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQ 908
G + LAGT Y R+G EK+ A GPT + + LLFQ N G+ YEYTI D L
Sbjct: 763 GNYKLAGTVFQYDRKGDLEKLMATGPTNESV-WIQLLFQVTNPGIKYEYTIQKDGL---- 817
Query: 909 SSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQI 968
+ + ++ W + W +C TCG G R+ T C K K +V C T+P +
Sbjct: 818 DNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIK---KGRGMVKATFCDPETQPNGRQ 874
Query: 969 RKCNEQPCQTRWMMTEWTPCSRTCG-KGMQSRQVACTQQLSNGTLIRARERDCIG-PKPA 1026
+KC+E+ C RW EW CS TCG G + R V C Q + + DC KP
Sbjct: 875 KKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQ-ALPPTDCQHLLKPK 933
Query: 1027 SAQRCEGQD-CMTVWEAGVWSECSVKCGKGIRHRTVRCT-NPRKKCVLSTRPREAEDC 1082
+ C C + W G WSECSV CG G+R R+V C N + C ++ +P C
Sbjct: 934 TLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALC 991
Score = 129 bits (325), Expect = 1e-29
Identities = 74/292 (25%), Positives = 125/292 (42%), Gaps = 30/292 (10%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
W +W +C TCG G V C+ M + C + +P+P ++C+ +PC
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMDSD--------CAAIQRPDPA-KRCHLRPC-A 1366
Query: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMT 1038
W + W+ CSR C G + R++ C + L + G P + C + C
Sbjct: 1367 GWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC-E 1425
Query: 1039 VWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWSK 1098
W+ WS+CS CG G++ R V C P C + RP C ++ C+ W G+W
Sbjct: 1426 AWQVEPWSQCSRSCGGGVQERGVFC--PGGLCDWTKRPTSTMSCNEHLCCH-WATGNWDL 1482
Query: 1099 CSITCGKGMQSRVIQCM----HKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTITS 1154
CS +CG G Q R +QC+ +K + C +P ++ C+ Q C + ++ T
Sbjct: 1483 CSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSADL-LCTK 1541
Query: 1155 PRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQKLQQK 1206
+L+A +C+ ++ C CC +C + Q++
Sbjct: 1542 DKLSA-----------SFCQTLKAMKKCSVPTVRAECCFSCPQTHITHTQRQ 1582
Score = 90.1 bits (222), Expect = 1e-17
Identities = 54/182 (29%), Positives = 78/182 (42%), Gaps = 27/182 (14%)
Query: 915 PLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTK-PEPQIRKCNE 973
P W +W C C GG + + C + S++ + C++L P P CN
Sbjct: 1364 PCAGWKVGNWSKCSRNCSGGFKIREIQC--VDSRDHRNLRPFHCQFLAGIPPPLSMSCNP 1421
Query: 974 QPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEG 1033
+PC+ W + W+ CSR+CG G+Q R V C L + T +P S C
Sbjct: 1422 EPCEA-WQVEPWSQCSRSCGGGVQERGVFCPGGLCDWT-----------KRPTSTMSCNE 1469
Query: 1034 QDCMTVWEAGVWSECSVKCGKGIRHRTVRC-------TNPRKKCVLSTRPREAEDCEDYS 1086
C W G W CS CG G + RTV+C T + +C+ +PR E +
Sbjct: 1470 HLCCH-WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPE----FK 1524
Query: 1087 KC 1088
KC
Sbjct: 1525 KC 1526
Score = 85.9 bits (211), Expect = 2e-16
Identities = 51/175 (29%), Positives = 75/175 (42%), Gaps = 17/175 (9%)
Query: 980 WMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTV 1039
W WT CS TCG G++ + C ++ +++A D ++C + C
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKK--GRGMVKATFCDPETQPNGRQKKCHEKACPPR 885
Query: 1040 WEAGVWSECSVKCGK-GIRHRTVRCTN---------PRKKCVLSTRPREAEDCEDYSKCY 1089
W AG W CS CG G + RTV C P C +P+ C C
Sbjct: 886 WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCP 945
Query: 1090 V-WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
W +G+WS+CS++CG G++ R + C H C + KP + C LQ C
Sbjct: 946 SDWTVGNWSECSVSCGGGVRIRSVTC----AKNHDEPCDVTRKPNSRALCGLQQC 996
Score = 62.0 bits (149), Expect = 3e-09
Identities = 39/135 (28%), Positives = 51/135 (37%), Gaps = 19/135 (14%)
Query: 905 PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKP 964
P S PEP W W C +CGGG ++ V C C + +P
Sbjct: 1413 PPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFC-----------PGGLCDWTKRP 1461
Query: 965 EPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCI--- 1021
+ CNE C W W CS +CG G Q R V C N T + C+
Sbjct: 1462 TSTM-SCNEHLC-CHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKT---EDQDQCLCDH 1516
Query: 1022 GPKPASAQRCEGQDC 1036
P+P ++C Q C
Sbjct: 1517 KPRPPEFKKCNQQAC 1531
Score = 43.1 bits (100), Expect = 0.002
Identities = 23/82 (28%), Positives = 40/82 (48%), Gaps = 3/82 (3%)
Query: 1064 TNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGR-H 1122
TNP K + + ++ D + + Y W+ G W++CS+TCG G++ + C+ K G
Sbjct: 802 TNPGIKYEYTIQ-KDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVK 860
Query: 1123 GNECFSSEKP-AAYRPCHLQPC 1143
C +P + CH + C
Sbjct: 861 ATFCDPETQPNGRQKKCHEKAC 882
Score = 38.9 bits (89), Expect = 0.030
Identities = 20/55 (36%), Positives = 25/55 (45%), Gaps = 2/55 (3%)
Query: 1092 RMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEK 1146
R WS CS TCG G+QS C + G C K YR C++ PC +
Sbjct: 547 RWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERK--RYRLCNVHPCRSE 599
Score = 32.7 bits (73), Expect = 2.1
Identities = 21/65 (32%), Positives = 30/65 (46%), Gaps = 16/65 (24%)
Query: 612 TDCDLGKWCKAGECTSRTSA-------PE-----HL--AGEWSL--WSPCSRTCSAGISS 655
T C LG + + EC+++ + P+ HL W + WS CSR CS G
Sbjct: 1327 TTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKI 1386
Query: 656 RERKC 660
RE +C
Sbjct: 1387 REIQC 1391
Score = 31.6 bits (70), Expect = 4.8
Identities = 11/21 (52%), Positives = 13/21 (61%)
Query: 642 WSPCSRTCSAGISSRERKCPG 662
WS CSR+C G+ R CPG
Sbjct: 1432 WSQCSRSCGGGVQERGVFCPG 1452
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 535 bits (1379), Expect = e-152
Identities = 348/1024 (33%), Positives = 476/1024 (46%), Gaps = 115/1024 (11%)
Query: 168 RIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVL 227
R AF ++L+L L+ L+ F V+ G GA+ +P CFY G +
Sbjct: 100 RFSAFGQELHLELKPSA-ILSSHFIVQVL-----GKDGASETQKPEVQQ---CFYQGFIR 150
Query: 228 RHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMA--------ITGHPHRVYRQKRSM 279
S + STC G L G I+ ++ I PL +A HPH +Y KR+
Sbjct: 151 NDSSSSVAVSTCAG-LSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLY--KRTA 207
Query: 280 EEKV--------------------------TEKSALH------SHYCGIISDKGRP---- 303
EEK+ + ++ H H+CG K P
Sbjct: 208 EEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGR-RKKYAPKPPT 266
Query: 304 -----RSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVF 358
R + SGR +R + K + N+ET+VVAD MV HG +ILT++NMV
Sbjct: 267 EDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVS 326
Query: 359 NLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEM 418
LF+ ++ +N+ V+ LILL + P L I HH ++ L SFC+WQ GK H
Sbjct: 327 GLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRH--- 383
Query: 419 STNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAF 478
D AIL+T D C K+EPCDT+G A +SGMCS+ R C I ED GL LAF
Sbjct: 384 -----------DHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAF 432
Query: 479 TIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKAS 538
TIAHE GHN G+ HD + C + + G N G SWS CS++ L++FL + +
Sbjct: 433 TIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNN-GVFSWSSCSRQYLKKFLSTPQA 491
Query: 539 NCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQ-EMQHVICTGLWCKVEG 597
CL+ P+ P KLPG Y AD QC+ FG A C IC LWC G
Sbjct: 492 GCLVD-EPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVG 550
Query: 598 EKECRTKLDPPMDGTDCDLGKWCKAGECTS-RTSAPEHLAGEWSL---WSPCSRTCSAGI 653
+ C TK P +GT C L WC+ G+C P + G+WS WS CSRTC G+
Sbjct: 551 HR-CETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGV 609
Query: 654 SSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKH-- 709
+ER C P C G + Y++C PC FR QC Y+ S P
Sbjct: 610 KFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYN---SKPFRGW 666
Query: 710 ILQWQ--AVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCD 767
QW+ ++EE C L+C E +S KV DGT C D+C +G C+ VGCD
Sbjct: 667 FYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCD 726
Query: 768 GLLGSLAREDHCGVCNGNGKSCKIIKGDF-NHTRGAGYVEVLVIPAGARRIKVVEEKPAH 826
LGS A D CGVC G+ +CK KG + N + Y V++IPAGAR I++ E + +
Sbjct: 727 HELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSS 786
Query: 827 SYLALRD-AGKQSINSDWKIEHSGAFNLAGTTVHYVRR-GLWEKISAKGPTTAPLHLLVL 884
SYLA+R + K + W I+ G F AGTT Y R E++ A GPT L + +
Sbjct: 787 SYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETL-VFEI 845
Query: 885 LFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTK 944
L Q +N G+ ++Y +P + P + W+ +C +CGGG C +
Sbjct: 846 LMQGKNPGIAWKYALPK--VMNGTPPATKRPAYTWSIVQ-SECSVSCGGGYINVKAICLR 902
Query: 945 IMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACT 1004
+ V++ C TKP + + CN C WM EW+ CS+ C G QSR++ C
Sbjct: 903 DQNTQ---VNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCV 959
Query: 1005 QQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC- 1063
Q+ C P Q C C W G WS+CS CG+G+R R + C
Sbjct: 960 QKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCK 1019
Query: 1064 -----TNPRKKCVLSTRPREAEDCEDYSKC-----YVWRMGDWSKCSITCGKGMQSRVIQ 1113
T P +C RP E C +C W WS+CS TCG G++ R ++
Sbjct: 1020 GSAAETLPESQCTSLPRPELQEGCV-LGRCPKNSRLQWVASSWSECSATCGLGVRKREMK 1078
Query: 1114 CMHK 1117
C K
Sbjct: 1079 CSEK 1082
Score = 89.7 bits (221), Expect = 1e-17
Identities = 57/215 (26%), Positives = 96/215 (44%), Gaps = 24/215 (11%)
Query: 886 FQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKI 945
FQ + LH + + + +S A P W+ W C TCG G RK + C
Sbjct: 964 FQKEEAVLHSLCPVSTPTQVQACNSHACPP--QWSLGPWSQCSKTCGRGVRKRELLCKGS 1021
Query: 946 MSKNISIVDNEKCKYLTKPEPQ----IRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQV 1001
++ + +C L +PE Q + +C + + +W+ + W+ CS TCG G++ R++
Sbjct: 1022 AAETLP---ESQCTSLPRPELQEGCVLGRCPKNS-RLQWVASSWSECSATCGLGVRKREM 1077
Query: 1002 ACTQQLSNGTLIRARERDCIGPKPAS---AQRCEGQDC--------MTVWEAGVWSECSV 1050
C+++ G LI ER C K + + C + C + W + W +C+V
Sbjct: 1078 KCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTV 1137
Query: 1051 KCGKGIRHRTVRCT---NPRKKCVLSTRPREAEDC 1082
CG G++ R+V C P C+L +P C
Sbjct: 1138 TCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRAC 1172
Score = 45.4 bits (106), Expect = 3e-04
Identities = 47/189 (24%), Positives = 73/189 (38%), Gaps = 36/189 (19%)
Query: 510 WIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQC 569
W+ G+ WS CSK +S+ C+ Q P ++ S P T T + C
Sbjct: 935 WMPGE------WSTCSKA-CAGGQQSRKIQCV-QKKPFQKEEAVLHSLCPVSTPTQVQAC 986
Query: 570 -------QILFGPLASFCQ------EMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDL 616
Q GP + + + ++C G + E +C T L P +L
Sbjct: 987 NSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQC-TSLPRP------EL 1039
Query: 617 GKWCKAGECTSRTSAPEHLAGEW--SLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPR 674
+ C G C P++ +W S WS CS TC G+ RE KC + + P
Sbjct: 1040 QEGCVLGRC------PKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPE 1093
Query: 675 KQYRICENP 683
++ R + P
Sbjct: 1094 RRCRNIKKP 1102
Score = 38.5 bits (88), Expect = 0.039
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 4/89 (4%)
Query: 1096 WSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNE-KINVNTITS 1154
WS+CS TCG G++ + C + G C S + Y+ C++ PCNE ++
Sbjct: 598 WSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSR--IYQLCNINPCNENSLDFRAQQC 655
Query: 1155 PRLAALTFKCLGDQWPVYCRVIREKNLCQ 1183
+ F+ QW Y +V E++ C+
Sbjct: 656 AEYNSKPFRGWFYQWKPYTKV-EEEDRCK 683
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 496 bits (1278), Expect = e-140
Identities = 368/1134 (32%), Positives = 519/1134 (45%), Gaps = 111/1134 (9%)
Query: 113 EDEELESQELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAF 172
+DE L S E + GA ++ PPPP + + + ++ +
Sbjct: 29 QDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESR-----LFYKVASP 83
Query: 173 SRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPG- 231
S L L R R LA +VE G A Q A P C Y G +
Sbjct: 84 STHFLLNLTRSSRLLAGHVSVEYWTREG-------LAWQRAARPH--CLYAGHLQGQAST 134
Query: 232 SLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSAL-H 290
S + STCGG L G I +E+ IEPL+ G P + S V ++S+L H
Sbjct: 135 SHVAISTCGG-LHGLIVADEEEYLIEPLH------GGPKGSRSPEESGPHVVYKRSSLRH 187
Query: 291 SHY---CGIISDK---GRP---------RSRKIA-ESGRGKR-YSYKLPQEYNIETVVVA 333
H CG+ +K GRP +R + E+ RG+ + +E +ET+VVA
Sbjct: 188 PHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVA 247
Query: 334 DPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHG 393
D MV+YHG +++L I+N+V LFQ SL VN+ V +LILL E P L I HH
Sbjct: 248 DKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITHHA 307
Query: 394 EKMLESFCKWQHE---EFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDT 450
K L+SFCKWQ G N I N D A+LITR D C++K++PC T
Sbjct: 308 GKSLDSFCKWQKSIVNHSGHGNAIPENGVANH-------DTAVLITRYDICIYKNKPCGT 360
Query: 451 VGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCA----DGLHIM 506
+G+A + GMC +R C + ED GL AFTIAHE+GH G+NHD SC D +M
Sbjct: 361 LGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLM 420
Query: 507 SGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTAD 566
+ N WS CS++ + FL S CL P+ + P+ PG Y AD
Sbjct: 421 AAHITMKTN--PFVWSSCSRDYITSFLDSGLGLCLNNRPPRQ--DFVYPTVAPGQAYDAD 476
Query: 567 EQCQILFGPLASFCQEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDC-----DLGKWCK 621
EQC+ G + C+ + +C+ LWC + + C T P +GT C D G WC
Sbjct: 477 EQCRFQHGVKSRQCKYGE--VCSELWCLSKSNR-CITNSIPAAEGTLCQTHTIDKG-WCY 532
Query: 622 AGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQ 676
C S PE + G W W+P CSRTC G+SS R C P + C G R++
Sbjct: 533 KRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRR 592
Query: 677 YRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEE-KPCALFCSPVGKEQP 735
+R C CP G FR+ QC + K +W+ K C+L C G
Sbjct: 593 HRSCNTDDCPPGSQDFREVQCSEFDSIPFRGK-FYKWKTYRGGGVKACSLTCLAEGFNFY 651
Query: 736 ILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGD 795
+ V+DGT C +DIC +G C+ VGCD +LGS RED C VC G+G +C+ I+G
Sbjct: 652 TERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGV 711
Query: 796 FNHTR-GAGYVEVLVIPAGARRIKVVEEKPAHSYLALR-DAGKQSINSDWKIEHSGAFNL 853
F+ GAGY +V+ IP G+ I + + + S+LAL+ D + L
Sbjct: 712 FSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPL 771
Query: 854 AGTTVHYVRRG--LWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSK 911
AGTT +R+G + + A GP A L ++VL + + L Y + P ++
Sbjct: 772 AGTTFQ-LRQGPDQVQSLEALGPINASLIVMVLA-RTELPALRYRFNAPI--------AR 821
Query: 912 APEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKC 971
P + W + W C A C GG + V C + S V C +K + R C
Sbjct: 822 DSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDS--SAVAPHYCSAHSKLPKRQRAC 879
Query: 972 NEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRC 1031
N +PC W++ W+ CSR+C G++SR V C +++S + C P+P + C
Sbjct: 880 NTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEAC 939
Query: 1032 EGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC-------TNPRKKCVLSTRPREAEDCED 1084
G C W A WSEC+ CG G+RHR V C T P C + +P C +
Sbjct: 940 HGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC-N 998
Query: 1085 YSKC--YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQP 1142
+C W G+W +CS CG G + R ++C TG+ +EC A RP Q
Sbjct: 999 LRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSH-TGQASHEC-----TEALRPPTTQQ 1052
Query: 1143 CNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCR 1196
C K + SP +C YC ++ + C + Q CC+TC+
Sbjct: 1053 CEAKCD-----SPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTCQ 1101
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 455 bits (1171), Expect = e-127
Identities = 315/1038 (30%), Positives = 484/1038 (46%), Gaps = 103/1038 (9%)
Query: 168 RIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVL 227
R A+ + L L D FLA + P G + + P CFY G V
Sbjct: 81 RFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRH----CFYRGQVN 136
Query: 228 RHPGSLASFSTCGGGLMGFIQLNEDFIFIEPL-----NDTMAITGHPHRVYRQKRS---- 278
A S CGG L G + F+EP+ N+ PH +YRQ +
Sbjct: 137 SQEDYKAVVSLCGG-LTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFL 195
Query: 279 --------MEEKVTEKSALHSHYCGIISDKGRPRSRKIAESGRG------KRYSYK---L 321
E ++ E S Y + D + R + + + +R+S K +
Sbjct: 196 QTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLI 255
Query: 322 PQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLH 381
IE +V AD +VS HG++ + +ILT++++V +++ S+ +++ V+KL+++H
Sbjct: 256 SYPRYIEIMVTADAKVVSAHGSNL-QNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIH 314
Query: 382 ETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFC 441
I G L++FC WQ + +D+H + D A+LITR+D C
Sbjct: 315 REEEGPVINFDGATTLKNFCSWQQTQ-NDLDDVH----------PSHHDTAVLITREDIC 363
Query: 442 VHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCAD 501
K E C+ +G++YL +C + C I E+ GL AFTIAHE+GH +G+ HD D+P C +
Sbjct: 364 SSK-EKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHD-DNPRCKE 421
Query: 502 ----GLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSK 557
H+M+ ++ SWS CS++ + FL + CLL + + ++ PS+
Sbjct: 422 MKVTKYHVMAPAL--SFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNL--PSE 477
Query: 558 LPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGE--KECRTKLDPPMDGTDCD 615
LPG Y ++QC++ FGP + C + IC LWC + K C T+ PP DGTDC
Sbjct: 478 LPGSRYDGNKQCELAFGPGSQMCPHIN--ICMHLWCTSTEKLHKGCFTQHVPPADGTDCG 535
Query: 616 LGKWCKAGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERKC--PGLDSEARDC 670
G C+ G C ++ + + GEW W P CSRTC GI S R+C P + C
Sbjct: 536 PGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYC 595
Query: 671 NGPRKQYRICENPPCPAGLPGFRDWQCQAYSVR-------TSSPKHILQWQAVLDEEKPC 723
G R ++R C CP G FR+ QC ++ + S+ + + ++ + +++ C
Sbjct: 596 VGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDR-C 654
Query: 724 ALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCN 783
L+C G LL + V DGT CG + DIC G+C GCD +L S A+ D CGVC
Sbjct: 655 KLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCG 714
Query: 784 GNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKV----VEEKPAHSYLALRDA-GKQS 838
G+ SCK I G FN + GY V+ IPAGA + + +P SYLAL DA G
Sbjct: 715 GDNSSCKTITGVFNSSH-YGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFL 773
Query: 839 INSDWKIEHS-GAFNLAG--TTVHYV-RRGLWEKISAKGPTTAPLHLLVLLFQD-QNYGL 893
N ++ + S N+ G T + Y E+I++ L L VL + N +
Sbjct: 774 FNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDV 833
Query: 894 HYEYTIPSDPLPENQSSKAPEPLFMW-THTSWEDCDATCGGGERKTTVSCTKIMSKNISI 952
HY + IP + + +F W + WE C C G +R+ + T I + S+
Sbjct: 834 HYSFNIPLEERSD---------MFTWDPYGPWEGCTKMCQGLQRR---NITCIHKSDHSV 881
Query: 953 VDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQ-QLSNGT 1011
V +++C +L P + CN C+ RW + + CS CG+G ++ + C + + G
Sbjct: 882 VSDKECDHLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQ 940
Query: 1012 LIRARERDCIGP-KPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKC 1070
++ + C KP + + C G T W WS+CS CG G R R C N
Sbjct: 941 TVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHR 1000
Query: 1071 VLSTRPRE-----AEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE 1125
+ +E E+C ++S C W +WS+C +TCGKG + R + C +
Sbjct: 1001 LADNECQELSRVTRENCNEFS-CPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGF 1059
Query: 1126 CFSSEKPAAYRPCHLQPC 1143
C SS KP + PC L C
Sbjct: 1060 CNSSTKPESLSPCELHTC 1077
Score = 128 bits (322), Expect = 3e-29
Identities = 75/250 (30%), Positives = 107/250 (42%), Gaps = 36/250 (14%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
W + W +C TCG G ++ V C N+ + + C TKPE + C C +
Sbjct: 1025 WAASEWSECLVTCGKGTKQRQVWC----QLNVDHLSDGFCNSSTKPE-SLSPCELHTCAS 1079
Query: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCI-GPKPASAQRCEGQDC- 1036
W + W PC+ TCG G Q R V C +L++ L + +C +P+ Q C C
Sbjct: 1080 -WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVL---EDTECHEASRPSDRQSCVLTPCS 1135
Query: 1037 -----------------MTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKK------CVLS 1073
M W G W+ CSV CG+G + R V C + + C
Sbjct: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHL 1195
Query: 1074 TRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPA 1133
RP E DC ++ C W+ GDWS CS +CG G +R + CM+ N C +P
Sbjct: 1196 PRPAEIWDC--FTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPL 1253
Query: 1134 AYRPCHLQPC 1143
+ C L C
Sbjct: 1254 MEQECSLAAC 1263
Score = 125 bits (315), Expect = 2e-28
Identities = 72/234 (30%), Positives = 109/234 (46%), Gaps = 20/234 (8%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
W W C ++C GG + V C ++ S C +KP P++++C PC
Sbjct: 1308 WRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASY-----CDAASKP-PELQQCGPGPCP- 1360
Query: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMT 1038
+W W CS+TCG G++SR V C Q NG ++ + + KP S +C C
Sbjct: 1361 QWNYGNWGECSQTCGGGIKSRLVIC--QFPNGQILEDHNCEIVN-KPPSVIQCHMHACPA 1417
Query: 1039 --VWEAGVWSECSVKCGKGIRHRTVRCTNPRKK------CVLSTRPREAEDCEDYSKCYV 1090
W W+ CS CGKG ++R V C + ++ C +P + C +C
Sbjct: 1418 DVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSV-RCPS 1476
Query: 1091 WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE-CFSSEKPAAYRPCHLQPC 1143
W+ W++CS+TCG G+Q R + C K G+ E C S +P + R C Q C
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
Score = 121 bits (303), Expect = 5e-27
Identities = 147/660 (22%), Positives = 250/660 (37%), Gaps = 81/660 (12%)
Query: 521 WSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFC 580
WS+CS+ RS+ S C+ + + ++ ++ E C P +
Sbjct: 975 WSQCSRS-CGGGERSRESYCM-----NNFGHRLADNECQELSRVTRENCNEFSCPSWAAS 1028
Query: 581 QEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPE-HLAGEW 639
+ + ++ G K + + C+ +D DG +C + S E H W
Sbjct: 1029 EWSECLVTCGKGTK-QRQVWCQLNVDHLSDG-------FCNSSTKPESLSPCELHTCASW 1080
Query: 640 SL--WSPCSRTCSAGISSRERKCPGL-------DSEARDCNGPRKQYRICENPPCPAGLP 690
+ W PC+ TC G R+ KC D+E + + P + + C PC
Sbjct: 1081 QVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDR-QSCVLTPC----- 1134
Query: 691 GFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSE---KVMDGTS 747
F + + + T K + QW+ PC++ C + + + + ++ D +
Sbjct: 1135 SFIS-KLETALLPTVLIKKMAQWRH--GSWTPCSVSCGRGTQARYVSCRDALDRIADESY 1191
Query: 748 CGYQGLDICANGRCQKVGCDGLLGSLAREDH--CGVCNGNGKSCK-IIKGDFNHTRGAGY 804
C + + C G D C G+GK+ + ++ +++ Y
Sbjct: 1192 CAHLPRP------AEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENY 1245
Query: 805 VEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQS-INSDWKIEHSGAFNLAGTTVHYVRR 863
+ V P + + PAHS+ ++++ + N VR
Sbjct: 1246 CDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRG 1305
Query: 864 GLWEKI---SAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWT 920
W S + L ++ QD+N G Y + PE Q P P W
Sbjct: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDEN-GQSASYCDAASKPPELQQC-GPGPCPQWN 1363
Query: 921 HTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPC--QT 978
+ +W +C TCGGG + V C N I+++ C+ + KP P + +C+ C
Sbjct: 1364 YGNWGECSQTCGGGIKSRLVIC---QFPNGQILEDHNCEIVNKP-PSVIQCHMHACPADV 1419
Query: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQDCM 1037
W WT CS +CGKG + R+V C Q + + +C KP + + C C
Sbjct: 1420 SWHQEPWTSCSASCGKGRKYREVFCIDQFQR----KLEDTNCSQVQKPPTHKACRSVRCP 1475
Query: 1038 TVWEAGVWSECSVKCGKGIRHRTVRCTNP------RKKCVLSTRPRE-----AEDCEDYS 1086
+ W+A W+ECSV CG G++ R V C + C STRP ++DC +
Sbjct: 1476 S-WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHK 1534
Query: 1087 KCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECF--SSEKPAAYRPCHLQPCN 1144
R+ CS +C + + ++C R NE SS + C PCN
Sbjct: 1535 GMERGRL----NCSTSCERKDSHQRMECTDNQI-RQVNEIVYNSSTISLTSKNCRNPPCN 1589
Score = 95.1 bits (235), Expect = 4e-19
Identities = 65/241 (26%), Positives = 99/241 (41%), Gaps = 24/241 (9%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPC-Q 977
W SW +C TCG G ++ V C K + V E C T+P Q R+C Q C Q
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRL---KGVGQVVEEMCDQSTRPCSQ-RRCWSQDCVQ 1532
Query: 978 TRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM 1037
+ M CS +C + +++ CT I +++ C C
Sbjct: 1533 HKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTIS---LTSKNCRNPPCN 1589
Query: 1038 TVWEAGVWSECSVKCGKGIRHRTVRCT---NPRKKCVLSTRPREAEDCEDYSKCYV---- 1090
+ S+C+ CG R R CT + +K + RP ++C V
Sbjct: 1590 YIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCI 1649
Query: 1091 --------WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQP 1142
W++G WSKCS+TCG G+ R ++C+ K G + C + KP A + C+
Sbjct: 1650 NSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITK-HGLSSDLCLNHLKPGAQKKCYAND 1708
Query: 1143 C 1143
C
Sbjct: 1709 C 1709
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 446 bits (1146), Expect = e-125
Identities = 325/1098 (29%), Positives = 491/1098 (44%), Gaps = 143/1098 (13%)
Query: 146 PQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTG 205
P PS P EP G + + F RDL+L LR + R +AP +E + G
Sbjct: 91 PVRTPSFPGGNEEEP-GSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRV- 148
Query: 206 AASAPQPPAPPDAGCFYTGAV--LRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTM 263
P C Y G V L S+A S C G L G I++ E+ FIEPL +
Sbjct: 149 --------EPLLGSCLYVGDVAGLAEASSVA-LSNCDG-LAGLIRMEEEEFFIEPLEKGL 198
Query: 264 AIT----GHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKI------AESGR 313
A G H VYR+ + + AL + G D SR + A S R
Sbjct: 199 AAQEAEQGRVHVVYRRPPT-SPPLGGPQALDT---GASLDSLDSLSRALGVLEEHANSSR 254
Query: 314 GKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLR 373
+ + +YNIE ++ D ++V +HG + ++++LT++N+V ++ +SL +N+
Sbjct: 255 RRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVV 314
Query: 374 VIKLILLH--ETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDA 431
++++ILL ++ + IG+ + LE+ C+W + L+ + G D D
Sbjct: 315 LVRIILLSYGKSMSLIEIGNPSQS-LENVCRWAY----------LQQKPDTGHDEYH-DH 362
Query: 432 AILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGIN 491
AI +TR+DF P G A ++GMC R C + ++G + AF +AHE GH +G+
Sbjct: 363 AIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGME 417
Query: 492 HDNDHPSCADGLHIMS--GEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSV 549
HD C D + + S ++ WSRCS+++L R+L S +CLL +P +
Sbjct: 418 HDGQGNRCGDEVRLGSIMAPLVQAA-FHRFHWSRCSQQELSRYLHSY--DCLLD-DPFAH 473
Query: 550 NSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVI-CTGLWCK-VEGEKECRTKLDP 607
+ +P +LPG+ Y+ +EQC+ FG C + C LWC + C+TK P
Sbjct: 474 DWPALP-QLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGP 532
Query: 608 PMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERKC--PG 662
P+DGT C GK C G C T G W WSP CSRTC G+ R R+C P
Sbjct: 533 PLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPH 592
Query: 663 LDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQW--QAVLDEE 720
+ R C+G +++C CP L FR+ QC+ + + W D +
Sbjct: 593 PANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAK 652
Query: 721 KPCALFCSPVGKEQPILLSEKVMDGTSCGYQ-GLDICANGRCQKVGCDGLLGSLAREDHC 779
+ C L+C + + + V DGT C Y+ +C G C+KVGCDG++GS +ED C
Sbjct: 653 ERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKC 712
Query: 780 GVCNGNGKSCKIIKGDFNHT-RGAGYVEVLVIPAGARRIKVVEEKPAHSYLALR--DAGK 836
GVC G+ CK++KG F + + GY+++ IPAGAR + + E +LA++ + GK
Sbjct: 713 GVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGK 772
Query: 837 QSINSDWKIEHSG-AFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHY 895
+N + ++ S F G Y E + GP + +LV+ D L Y
Sbjct: 773 FILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTY 832
Query: 896 EYTIPSDPL--PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIV 953
+Y I D L +N + ++ W W C CGGG + T C + + +V
Sbjct: 833 KYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDH--KMV 890
Query: 954 DNEKCKYLTKPEPQIRKCNEQPC-QTRWMMTEWTPCSRTCGK-GMQSRQVACTQQLSNGT 1011
C L+KP+ R CN Q C Q W+ EW PCS+TCG+ GMQ R V C Q L + T
Sbjct: 891 HRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNT 950
Query: 1012 LIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCV 1071
+ C +P S + C + C W AG WS+CSV CG G + R V C
Sbjct: 951 TRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC-------- 1002
Query: 1072 LSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEK 1131
R A+D + C E+
Sbjct: 1003 -----RTADD--SFGIC---------------------------------------QEER 1016
Query: 1132 PAAYRPCHLQPCNEKIN--------VNTITSP------RLAALTFKCLGDQWPVYCRVIR 1177
P R C L PC I+ V ++ P R + C GD+ ++CR+
Sbjct: 1017 PETARTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDK-SIFCRMEV 1075
Query: 1178 EKNLCQDMRWYQRCCETC 1195
C + + CC++C
Sbjct: 1076 LSRYCSIPGYNKLCCKSC 1093
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 440 bits (1132), Expect = e-123
Identities = 313/1050 (29%), Positives = 483/1050 (46%), Gaps = 116/1050 (11%)
Query: 168 RIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVL 227
R+ AF + L + F+AP F V PG T S + CFY G V
Sbjct: 101 RLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKH---CFYKGYVN 157
Query: 228 RHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLN-----DTMAITGHPHRVYRQKRSMEEK 282
+ A S C G ++G + ++ FIEPL + PH +YR+ E
Sbjct: 158 TNSEHTAVISLCSG-MLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREP 216
Query: 283 VTEKSALHS--HYCGIISDKGRPRSRKIAE----------------------------SG 312
T + A + H DK + R+RK E +
Sbjct: 217 STGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNT 276
Query: 313 RGKRYSYKLPQEYN----IETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSV 368
R KR + + + +E +VVAD MVSYHG + + +ILT++++V ++++ S+
Sbjct: 277 REKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENL-QHYILTLMSIVASIYKDPSIGN 335
Query: 369 QVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTS 428
+N+ ++ LI++H I + + L++FC+WQH + H
Sbjct: 336 LINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHH------------- 382
Query: 429 VDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNM 488
D A+L+TR+D C D+ CDT+G+A L +C R C I+ED+GL+ AFTIAHE+GH
Sbjct: 383 -DTAVLLTRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVF 440
Query: 489 GINHDNDHPSCADGLHIMSGEWIKGQNLGDVS----WSRCSKEDLERFLRSKASNCLLQT 544
+ HD+++ +G + S + + L + WS+CS++ + FL + CLL
Sbjct: 441 NMPHDDNNKCKEEG--VKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLN- 497
Query: 545 NPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCK-VEG-EKECR 602
P+S +P +LPG+ Y ++QC+++FGP + C M C LWC V G K CR
Sbjct: 498 EPES-RPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVNGVHKGCR 554
Query: 603 TKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERK 659
T+ P DGT+C+ GK CK G C + G W WSP CSRTC GI + R+
Sbjct: 555 TQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRE 614
Query: 660 C--PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHIL------ 711
C P + + C G R +++ C PC FRD QC + + + +L
Sbjct: 615 CNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWV 674
Query: 712 -QWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLL 770
++ +L +++ C LFC G L ++V+DGT CG DIC G C++ GCD +L
Sbjct: 675 PKYSGILMKDR-CKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVL 733
Query: 771 GSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVE-----EKPA 825
S AR D CGVC G+ SCK + G FN T GY V+ IPAGA I V + E
Sbjct: 734 NSKARRDKCGVCGGDNSSCKTVAGTFN-TVHYGYNTVVRIPAGATNIDVRQHSFSGETDD 792
Query: 826 HSYLALRDA-GKQSINSDWKIEHS-GAFNLAGTTVHYV-RRGLWEKISAKGPTTAPLHLL 882
+YLAL + G+ +N ++ + + + V Y E+I++ L L
Sbjct: 793 DNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQ 852
Query: 883 VL-LFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMW-THTSWEDCDATCGGGERKTTV 940
VL + + N + Y + IP + P+ F W +H W+ C C GERK +
Sbjct: 853 VLSVGKLYNPDVRYSFNIPIEDKPQQ---------FYWNSHGPWQACSKPC-QGERKRKL 902
Query: 941 SCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQ 1000
CT+ + V +++C L +P C C RW + + CS CG G ++
Sbjct: 903 VCTR--ESDQLTVSDQRCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRTLD 959
Query: 1001 VACTQ-QLSNGTLIRARERDCIG-PKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRH 1058
+ C + +G + + C PKP++ ++C G+ W W+ECS C G +
Sbjct: 960 IYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQR 1019
Query: 1059 RTVRCTNPRKKCVLSTRPREAED-----CEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQ 1113
R C N R + ++ E C ++ C W+ GDWS+C +TCGKG + R +
Sbjct: 1020 RRAICVNTRNDVLDDSKCTHQEKVTIQRCSEF-PCPQWKSGDWSECLVTCGKGHKHRQVW 1078
Query: 1114 CMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
C + C KP + + C C
Sbjct: 1079 CQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
Score = 156 bits (395), Expect = 1e-37
Identities = 85/241 (35%), Positives = 126/241 (52%), Gaps = 26/241 (10%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
W+ W C +CG G ++ V C M+K+ S ++++ CK+L KP RKC C
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYC---MAKDGSHLESDYCKHLAKPHGH-RKCRGGRCP- 1499
Query: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQDC- 1036
+W W+ CS +CG+G+Q R V C GT ARE +C +P S + C+G C
Sbjct: 1500 KWKAGAWSQCSVSCGRGVQQRHVGC----QIGTHKIARETECNPYTRPESERDCQGPRCP 1555
Query: 1037 MTVWEAGVWSECSVKCGKGIRHRTVRCTNPRK------KCVLSTRPREAEDCEDYSKCYV 1090
+ W A W EC+ CG+G R+R V C + K +C +S RP + E C YV
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615
Query: 1091 WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE--------CFSSEKPAAYRPCHLQP 1142
W G+WS+CS+TCGKG + R++ C TG+ E C ++ P+ + PC+L+
Sbjct: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVH-PCYLRD 1674
Query: 1143 C 1143
C
Sbjct: 1675 C 1675
Score = 142 bits (358), Expect = 2e-33
Identities = 145/583 (24%), Positives = 221/583 (37%), Gaps = 77/583 (13%)
Query: 591 LWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCS 650
+WC+ ++ DP T C+ EC S + P W CS TC
Sbjct: 1077 VWCQFGEDRLNDRMCDPETKPTSMQT---CQQPECASWQAGP---------WGQCSVTCG 1124
Query: 651 AGISSRERKC------PGLDSEARDCNGPRK--QYRICENPPC--PAGLPGFRDWQCQAY 700
G R KC +D DCN + + CE P C P P R
Sbjct: 1125 QGYQLRAVKCIIGTYMSVVDDN--DCNAATRPTDTQDCELPSCHPPPAAPETR------- 1175
Query: 701 SVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEK---VMDGTSCGYQGLDICA 757
R++ QW+ PC+ C + + + ++ V D ++C + A
Sbjct: 1176 --RSTYSAPRTQWR--FGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPV-A 1230
Query: 758 NGRCQKVGCDGLLGSLARED--HCGVCNGNGKSCKIIK--GDFNHTRGAGYVEVLVIPAG 813
C C G D C V G G++ + + +H + IP
Sbjct: 1231 KEECSVTPC----GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPET 1286
Query: 814 ARRIKV--VEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAGTTVHYVRRGLWEKISA 871
+ + ++ S LA N D++ + + R G W S+
Sbjct: 1287 DQDCSMSPCPQRTPDSGLAQHPFQ----NEDYRPRSASPSRTHVLGGNQWRTGPWGACSS 1342
Query: 872 KGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCDATC 931
+ ++V QD+N + P + P P W + +W +C C
Sbjct: 1343 TCAGGSQRRVVVC--QDENGYTANDCVERIKPDEQRACESGPCP--QWAYGNWGECTKLC 1398
Query: 932 GGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPC--QTRWMMTEWTPCS 989
GGG R V C + N + C+ L KP P +CN C W W+ CS
Sbjct: 1399 GGGIRTRLVVCQR---SNGERFPDLSCEILDKP-PDREQCNTHACPHDAAWSTGPWSSCS 1454
Query: 990 RTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECS 1049
+CG+G + R V C +G+ + + + KP ++C G C W+AG WS+CS
Sbjct: 1455 VSCGRGHKQRNVYC--MAKDGSHLESDYCKHLA-KPHGHRKCRGGRC-PKWKAGAWSQCS 1510
Query: 1050 VKCGKGIRHRTVRCTNPRKK------CVLSTRPREAEDCEDYSKC--YVWRMGDWSKCSI 1101
V CG+G++ R V C K C TRP DC+ +C Y WR +W +C+
Sbjct: 1511 VSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQG-PRCPLYTWRAEEWQECTK 1569
Query: 1102 TCGKGMQSRVIQCMHKITGR-HGNECFSSEKPAAYRPCHLQPC 1143
TCG+G + R + C+ HG C S++P C LQPC
Sbjct: 1570 TCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 121 bits (304), Expect = 4e-27
Identities = 71/236 (30%), Positives = 100/236 (42%), Gaps = 25/236 (10%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
W +W C +CG G ++ V C K I +C T+PE + R C C
Sbjct: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHK---IARETECNPYTRPESE-RDCQGPRCPL 1556
Query: 979 -RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM 1037
W EW C++TCG+G + R+V C N R + +P + C Q C
Sbjct: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEV---HGARCDVSKRPVDRESCSLQPCE 1613
Query: 1038 TVWEAGVWSECSVKCGKGIRHRTVRCTN-------------PRKKCVLSTRPREAEDC-- 1082
VW G WSECSV CGKG + R V C+ C T+P C
Sbjct: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP-GTQPPSVHPCYL 1672
Query: 1083 EDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPC 1138
D WR+G+W CS++CG G+ R +QC+ + + C + KP + C
Sbjct: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTN-EDQPSHLCHTDLKPEERKTC 1727
Score = 115 bits (289), Expect = 2e-25
Identities = 74/259 (28%), Positives = 106/259 (40%), Gaps = 39/259 (15%)
Query: 915 PLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQ 974
P W W +C TCG G + V C + +++ C TKP ++ C +
Sbjct: 1052 PCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDR----LNDRMCDPETKPT-SMQTCQQP 1106
Query: 975 PCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC-IGPKPASAQRCEG 1033
C + W W CS TCG+G Q R V C + + + DC +P Q CE
Sbjct: 1107 ECAS-WQAGPWGQCSVTCGQGYQLRAVKC---IIGTYMSVVDDNDCNAATRPTDTQDCEL 1162
Query: 1034 QDC-----------------MTVWEAGVWSECSVKCGKGIRHRTVRCTN------PRKKC 1070
C T W G W+ CS CGKG R R V C + C
Sbjct: 1163 PSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESAC 1222
Query: 1071 VLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMH---KITGRHGNECF 1127
RP E+C + C W+ DWS CS+TCG+G +R + C++ + R +EC
Sbjct: 1223 ATLPRPVAKEEC-SVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDR--SECD 1279
Query: 1128 SSEKPAAYRPCHLQPCNEK 1146
P + C + PC ++
Sbjct: 1280 QDYIPETDQDCSMSPCPQR 1298
Score = 113 bits (283), Expect = 1e-24
Identities = 61/183 (33%), Positives = 87/183 (47%), Gaps = 13/183 (7%)
Query: 915 PLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQ 974
PL+ W W++C TCG G R V C + N + V +C +P + C+ Q
Sbjct: 1555 PLYTWRAEEWQECTKTCGEGSRYRKVVC---VDDNKNEVHGARCDVSKRPVDR-ESCSLQ 1610
Query: 975 PCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLS---NGTLIRARERDCIGPKPASAQRC 1031
PC+ W+ EW+ CS TCGKG + R V+C++ + N +C G +P S C
Sbjct: 1611 PCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPC 1670
Query: 1032 EGQDC--MTVWEAGVWSECSVKCGKGIRHRTVRC-TN---PRKKCVLSTRPREAEDCEDY 1085
+DC W G W CSV CG G+ R+V+C TN P C +P E + C +
Sbjct: 1671 YLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNV 1730
Query: 1086 SKC 1088
C
Sbjct: 1731 YNC 1733
Score = 38.9 bits (89), Expect = 0.030
Identities = 51/207 (24%), Positives = 77/207 (37%), Gaps = 49/207 (23%)
Query: 538 SNCLLQTNPQSVNSVMVPSKLPG--------MTYTADEQCQILFG---PLASFCQE---M 583
++C T P +PS P TY+A + Q FG P ++ C + M
Sbjct: 1146 NDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAP-RTQWRFGSWTPCSATCGKGTRM 1204
Query: 584 QHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSL-- 641
++V C V E C T L P+ +C + G+W
Sbjct: 1205 RYVSCRDENGSVADESACAT-LPRPVAKEECSVTP-----------------CGQWKALD 1246
Query: 642 WSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQY-----RICENPPCPAGLP----GF 692
WS CS TC G ++R+ C D + + Y + C PCP P
Sbjct: 1247 WSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQ 1306
Query: 693 RDWQCQAYSVRTSSPK--HIL---QWQ 714
+Q + Y R++SP H+L QW+
Sbjct: 1307 HPFQNEDYRPRSASPSRTHVLGGNQWR 1333
Score = 34.7 bits (78), Expect = 0.56
Identities = 29/106 (27%), Positives = 36/106 (33%), Gaps = 23/106 (21%)
Query: 590 GLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSL-------- 641
G + V + +C P D DC+L C +APE +S
Sbjct: 1137 GTYMSVVDDNDCNAATRPT-DTQDCELPS------CHPPPAAPETRRSTYSAPRTQWRFG 1189
Query: 642 -WSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCP 686
W+PCS TC G R C RD NG C P P
Sbjct: 1190 SWTPCSATCGKGTRMRYVSC-------RDENGSVADESACATLPRP 1228
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 438 bits (1127), Expect = e-122
Identities = 324/1124 (28%), Positives = 500/1124 (44%), Gaps = 140/1124 (12%)
Query: 127 SGAAALSPGAPASWQPPPPPQPPPSPPPAQHA-EPDGD---------EVLLRIPAFSRDL 176
SG AA S G+ PP P+ A+ P G + + F ++L
Sbjct: 58 SGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKEL 117
Query: 177 YLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASF 236
+L LR + R + P +VE + + P C YTG V PG+ +
Sbjct: 118 HLRLRPNRRLVVPGSSVEWQED---------FRELFRQPLRQECVYTGGVTGMPGAAVAI 168
Query: 237 STCGGGLMGFIQLNEDFIFIEPLN---DTMAITGHPHRVYRQKRSMEEKVTEKSALHS-- 291
S C G L G I+ + FIEPL +G H VYR++ +E LH+
Sbjct: 169 SNCDG-LAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEA 227
Query: 292 -------HYCGIISDKGRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGAD 344
+ G++ D+ + ++ R +R++ P Y+IE ++V D ++V +HG +
Sbjct: 228 FGLGDLPNLLGLVGDQ-------LGDTERKRRHAK--PGSYSIEVLLVVDDSVVRFHGKE 278
Query: 345 AARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILL-HETPPELYIGHHGEKMLESFCKW 403
+ ++LT++N+V ++ +SL V +N+ +++LI++ + L + + LE C+W
Sbjct: 279 HVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRW 338
Query: 404 QHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEK 463
H + +++ H E D + +TR+DF P G A ++GMC
Sbjct: 339 AHSQ-QRQDPSHAEHH----------DHVVFLTRQDF-----GPSGMQGYAPVTGMCHPL 382
Query: 464 RKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCAD--GLHIMSGEWIKGQNLGDVSW 521
R C + ++G + AF IAHE GH +G+ HD CAD L + ++ W
Sbjct: 383 RSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAA-FHRFHW 441
Query: 522 SRCSKEDLERFLRSKASNCLLQTN-----PQSVNSVMVPSKLPGMTYTADEQCQILFGPL 576
SRCSK +L R+L S +CLL PQ P +LPG+ Y+ DEQC+ FG
Sbjct: 442 SRCSKLELSRYLPSY--DCLLDDPFDPAWPQ-------PPELPGINYSMDEQCRFDFGSG 492
Query: 577 ASFCQEMQHVI-CTGLWCK-VEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEH 634
C + C LWC + C+TK PP+DGT+C GKWC G C ++ PE
Sbjct: 493 YQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKS--PEQ 550
Query: 635 LAGE---WSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCP 686
G+ WS W+ CSR+C G+ SR R C P R C GP +Y++C + CP
Sbjct: 551 TYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610
Query: 687 AGLPGFRDWQC---QAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVM 743
FR QC +Y V ++ + ++ D +K C L C + +++ V
Sbjct: 611 GTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQK-CELICQSADTGDVVFMNQVVH 669
Query: 744 DGTSCGYQG-LDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNH-TRG 801
DGT C Y+ +CA G C VGCD +GS+ +D CGVC G+ C+ +KG ++
Sbjct: 670 DGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQ 729
Query: 802 AGYVEVLVIPAGARRIKV--VEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAGTTVH 859
AG ++++ IPAGAR I++ +E+ P + + G +N K S F G
Sbjct: 730 AGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWE 789
Query: 860 YVRRGLWEKISAKGPTTAPLHLLVLLFQD--QNYGLHYEYTIPSDPLP---ENQSSKAPE 914
E + GP + +L L + L Y+Y I D LP N
Sbjct: 790 DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEM 849
Query: 915 PLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQ 974
+ W SW C CGGG + T C + ++ +V C + +P+P R+CN+
Sbjct: 850 DTYEWALKSWAPCSKACGGGIQFTKYGCRR--RRDHHMVQRHLCDHKKRPKPIRRRCNQH 907
Query: 975 PC-QTRWMMTEWTPCSRTCGK-GMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCE 1032
PC Q W+ EW CSR+CGK G+Q+R + C LSNGT + C G +P + + C
Sbjct: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 967
Query: 1033 GQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWR 1092
C W G WS+CS CG+GI+ R V C + C R
Sbjct: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRT---------------NANSLGHCEGDR 1012
Query: 1093 MGDWSKCSI-TCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNT 1151
CS+ CG Q+ ++ G + +P L P +N
Sbjct: 1013 PDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEP-------LHP------INK 1059
Query: 1152 ITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETC 1195
I+S T C GD+ V+C++ C +++ CC +C
Sbjct: 1060 ISS------TEPCTGDR-SVFCQMEVLDRYCSIPGYHRLCCVSC 1096
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 436 bits (1121), Expect = e-122
Identities = 310/1089 (28%), Positives = 487/1089 (44%), Gaps = 156/1089 (14%)
Query: 155 AQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQR-----------PNPGPGP 203
A+ + +++ I AF +D +L L+ + + +AP VE P P
Sbjct: 70 ARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQP 129
Query: 204 TGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTM 263
A + P C Y G ++ PG+ + S C G L G I+ + + FIEPL
Sbjct: 130 GSATYRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDG-LAGMIKSDNEEYFIEPLERGK 188
Query: 264 AIT---GHPHRVYRQKRSMEEKVTEKSALHSHYCGI--ISDKGRPRS---RKIAESGRGK 315
+ G H VY++ + + H + + D G +++ E+ R +
Sbjct: 189 QMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRR 248
Query: 316 RYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVI 375
R++ + +YNIE ++ D ++V +HG + + ++LT++N+V ++ +SL V +N+ ++
Sbjct: 249 RHAGE--NDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLV 306
Query: 376 KLILL-HETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAIL 434
++I+L + L + + LE+ C+W ++ +++D+ N E D AI
Sbjct: 307 RMIMLGYAKSISLIERGNPSRSLENVCRWASQQ--QRSDL------NHSEHH---DHAIF 355
Query: 435 ITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDN 494
+TR+DF P G A ++GMC R C + ++G + AF +AHE GH +G+ HD
Sbjct: 356 LTRQDF-----GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 410
Query: 495 DHPSCADGLHIMSGEWIKGQNLGDV--------SWSRCSKEDLERFLRSKASNCLLQTNP 546
C D E G + + WSRCS ++L+R++ S +CLL +P
Sbjct: 411 QGNRCGD-------ETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLD-DP 460
Query: 547 QSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVI-CTGLWCK-VEGEKECRTK 604
+ +P +LPG+ Y+ DEQC+ FG C + C LWC + C+TK
Sbjct: 461 FDHDWPKLP-ELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTK 519
Query: 605 LDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERKC- 660
PP+DGT+C GKWC G C + + + G W W+ CSRTC G+ R R+C
Sbjct: 520 KGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCN 579
Query: 661 -PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQ---AYSVRTSSPKHILQWQAV 716
P + +DC G +Y++C C FR QCQ ++ ++ H L ++
Sbjct: 580 NPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHP 639
Query: 717 LDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQG-LDICANGRCQKVGCDGLLGSLAR 775
D +K C L+C + + V DGT C Y+ IC G C KVGCD +GS
Sbjct: 640 -DPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKV 698
Query: 776 EDHCGVCNGNGKSCKIIKGDFNHT-RGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRD- 833
ED CGVC G+ C+ +KG F T R GY+++ IP GAR + + E++ + LA+++
Sbjct: 699 EDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQ 758
Query: 834 -AGKQSINSDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQ-DQNY 891
G +N + S F G Y E + GP P+ +L++ + D
Sbjct: 759 ATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRS 818
Query: 892 GLHYEYTIPSDPLPE-NQSSKAPEPL--FMWTHTSWEDCDATCGGGERKTTVSCTKIMSK 948
L Y+Y I D +P N ++ E L F W SW C CGGG + T C +
Sbjct: 819 SLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRR--KS 876
Query: 949 NISIVDNEKCKYLTKPEPQIRKCNEQPC-QTRWMMTEWTPCSRTCGK-GMQSRQVACTQQ 1006
+ +V C+ KP+P R CN Q C W+ EW C++TCG G Q R V C Q
Sbjct: 877 DNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQP 936
Query: 1007 LSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNP 1066
L +GT + C+G +P S + C C W+ G WSECSV CG+G R V C
Sbjct: 937 LLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC--- 993
Query: 1067 RKKCVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNEC 1126
R + C+
Sbjct: 994 ----------RAGDHCD------------------------------------------- 1000
Query: 1127 FSSEKPAAYRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMR 1186
EKP + R C L PCN++ CLGD+ ++C++ C
Sbjct: 1001 --GEKPESVRACQLPPCNDE----------------PCLGDK-SIFCQMEVLARYCSIPG 1041
Query: 1187 WYQRCCETC 1195
+ + CCE+C
Sbjct: 1042 YNKLCCESC 1050
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 436 bits (1120), Expect = e-122
Identities = 323/1124 (28%), Positives = 499/1124 (44%), Gaps = 143/1124 (12%)
Query: 127 SGAAALSPGAPASWQPPPPPQPPPSPPPAQHA-EPDGD---------EVLLRIPAFSRDL 176
SG AA S G+ PP P+ A+ P G + + F ++L
Sbjct: 58 SGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKEL 117
Query: 177 YLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASF 236
+L LR + R + P +VE + + P C YTG V PG+ +
Sbjct: 118 HLRLRPNRRLVVPGSSVEWQED---------FRELFRQPLRQECVYTGGVTGMPGAAVAI 168
Query: 237 STCGGGLMGFIQLNEDFIFIEPLN---DTMAITGHPHRVYRQKRSMEEKVTEKSALHS-- 291
S C G L G I+ + FIEPL +G H VYR++ +E LH+
Sbjct: 169 SNCDG-LAGLIRTDSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEA 227
Query: 292 -------HYCGIISDKGRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGAD 344
+ G++ D+ + ++ R +R++ P Y+IE ++V D ++V +HG +
Sbjct: 228 FGLGDLPNLLGLVGDQ-------LGDTERKRRHAK--PGSYSIEVLLVVDDSVVRFHGKE 278
Query: 345 AARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILL-HETPPELYIGHHGEKMLESFCKW 403
+ ++LT++N+V ++ +SL V +N+ +++LI++ + L + + LE C+W
Sbjct: 279 HVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRW 338
Query: 404 QHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEK 463
H + +++ H E D + +TR+DF G A ++GMC
Sbjct: 339 AHSQ-QRQDPSHAEHH----------DHVVFLTRQDF--------GPSGYAPVTGMCHPL 379
Query: 464 RKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCAD--GLHIMSGEWIKGQNLGDVSW 521
R C + ++G + AF IAHE GH +G+ HD CAD L + ++ W
Sbjct: 380 RSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAA-FHRFHW 438
Query: 522 SRCSKEDLERFLRSKASNCLLQTN-----PQSVNSVMVPSKLPGMTYTADEQCQILFGPL 576
SRCSK +L R+L S +CLL PQ P +LPG+ Y+ DEQC+ FG
Sbjct: 439 SRCSKLELSRYLPSY--DCLLDDPFDPAWPQ-------PPELPGINYSMDEQCRFDFGSG 489
Query: 577 ASFCQEMQHVI-CTGLWCK-VEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEH 634
C + C LWC + C+TK PP+DGT+C GKWC G C ++ PE
Sbjct: 490 YQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKS--PEQ 547
Query: 635 LAGE---WSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCP 686
G+ WS W+ CSR+C G+ SR R C P R C GP +Y++C + CP
Sbjct: 548 TYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 607
Query: 687 AGLPGFRDWQC---QAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVM 743
FR QC +Y V ++ + ++ D +K C L C + +++ V
Sbjct: 608 GTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQK-CELICQSADTGDVVFMNQVVH 666
Query: 744 DGTSCGYQG-LDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNH-TRG 801
DGT C Y+ +CA G C VGCD +GS+ +D CGVC G+ C+ +KG ++
Sbjct: 667 DGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQ 726
Query: 802 AGYVEVLVIPAGARRIKV--VEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAGTTVH 859
AG ++++ IPAGAR I++ +E+ P + + G +N K S F G
Sbjct: 727 AGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWE 786
Query: 860 YVRRGLWEKISAKGPTTAPLHLLVLLFQD--QNYGLHYEYTIPSDPLP---ENQSSKAPE 914
E + GP + +L L + L Y+Y I D LP N
Sbjct: 787 DAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEM 846
Query: 915 PLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQ 974
+ W SW C CGGG + T C + ++ +V C + +P+P R+CN+
Sbjct: 847 DTYEWALKSWAPCSKACGGGIQFTKYGCRR--RRDHHMVQRHLCDHKKRPKPIRRRCNQH 904
Query: 975 PC-QTRWMMTEWTPCSRTCGK-GMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCE 1032
PC Q W+ EW CSR+CGK G+Q+R + C LSNGT + C G +P + + C
Sbjct: 905 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 964
Query: 1033 GQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWR 1092
C W G WS+CS CG+GI+ R V C + C R
Sbjct: 965 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRT---------------NANSLGHCEGDR 1009
Query: 1093 MGDWSKCSI-TCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNT 1151
CS+ CG Q+ ++ G + +P L P +N
Sbjct: 1010 PDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEP-------LHP------INK 1056
Query: 1152 ITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETC 1195
I+S T C GD+ V+C++ C +++ CC +C
Sbjct: 1057 ISS------TEPCTGDR-SVFCQMEVLDRYCSIPGYHRLCCVSC 1093
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin type)
with thrombospondin type 1 motif, 15 preproprotein [Homo
sapiens]
Length = 950
Score = 403 bits (1035), Expect = e-112
Identities = 306/950 (32%), Positives = 438/950 (46%), Gaps = 117/950 (12%)
Query: 159 EPDGDEVLL-RIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPD 217
E GD+ L+ +I AF D YL L D +FLAP F+ E P G TG +S +
Sbjct: 46 EDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRR----- 100
Query: 218 AGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKR 277
CFY+G V P S A+ S CGG F +++ I PL + A +
Sbjct: 101 --CFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYV-ISPLPNASAPAAQRNSQGAHLL 157
Query: 278 SMEEKVTEKSALHSHYCGIIS----------DKGRPR------SRKIAESGRGKRYSYKL 321
S + CG+ S D +PR SR SGR KR+ +
Sbjct: 158 QRRGVPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRF-VSI 216
Query: 322 PQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLH 381
P+ +ET+VVAD +MV +HGAD ++LT+L L++H S+ +N+ V+K++LL
Sbjct: 217 PRY--VETLVVADESMVKFHGADL-EHYLLTLLATAARLYRHPSILNPINIVVVKVLLLR 273
Query: 382 ETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFC 441
+ + + L +FC WQ ++ K +D H E W D AIL TR+D C
Sbjct: 274 DRDSGPKVTGNAALTLRNFCAWQ-KKLNKVSDKHPEY---W-------DTAILFTRQDLC 322
Query: 442 VHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCAD 501
CDT+G+A + MC KR C + ED+GL AFT AHE+GH + HDN C +
Sbjct: 323 --GATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKV-CEE 379
Query: 502 GL------HIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVP 555
H+MS I+ WS CS + FL S +CLL Q + +P
Sbjct: 380 VFGKLRANHMMSPTLIQIDRANP--WSACSAAIITDFLDSGHGDCLLD---QPSKPISLP 434
Query: 556 SKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWC--KVEGEKECRTKLDPPMDGTD 613
LPG +YT +QC++ FG + C MQ+ CT LWC K +G+ C+T+ P DGT
Sbjct: 435 EDLPGASYTLSQQCELAFGVGSKPCPYMQY--CTKLWCTGKAKGQMVCQTRHFPWADGTS 492
Query: 614 CDLGKWCKAGECTSRTSAPEH-LAGEWSLWSP---CSRTCSAGISSRERKC--PGLDSEA 667
C GK C G C R + +H + G W+ W P CSRTC G+ R+C P +
Sbjct: 493 CGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGG 552
Query: 668 RDCNGPRKQYRICENPPCPAGLPG--FRDWQCQAYSVRTSSPKHIL-------QWQAVLD 718
+ C G R +YR C PCP+ G FR+ QC+A++ S + ++ V
Sbjct: 553 KYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSP 612
Query: 719 EEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDH 778
+K C L C G +L+ KV+DGT C +C G+C K GCDG LGS R D
Sbjct: 613 RDK-CKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDK 671
Query: 779 CGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPA-----HSYLALRD 833
CGVC G+ KSCK + G F GY V+ IPAGA I + + +YLAL++
Sbjct: 672 CGVCGGDNKSCKKVTGLFTKPMH-GYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKN 730
Query: 834 A-GKQSINSDWKIEH-SGAFNLAGTTVHYVRRGLW-EKISAKGPTTAPLHLLVLLFQDQN 890
+ GK +N + + + G+ + Y G E + A P PL + VL
Sbjct: 731 SQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMT 790
Query: 891 YG-LHYEYTIPSDPLPENQSS-KAPE----------------------PLFMWTHTSWED 926
+ Y + +P +P + S K P P W SW
Sbjct: 791 PPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGP 850
Query: 927 CDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWT 986
C A+CG G +K V C + C +P + + C E PC T W ++ W+
Sbjct: 851 CSASCGSGLQKRAVDCRGSAGQRTV----PACDAAHRPV-ETQACGE-PCPT-WELSAWS 903
Query: 987 PCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDC 1036
PCS++CG+G Q R + C + +G + AR++ + KP C + C
Sbjct: 904 PCSKSCGRGFQRRSLKC---VGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 70.9 bits (172), Expect = 7e-12
Identities = 37/110 (33%), Positives = 52/110 (47%), Gaps = 8/110 (7%)
Query: 1040 WEAGVWSECSVKCGKGIRHRTVRCTNPRKK-----CVLSTRPREAEDCEDYSKCYVWRMG 1094
W AG W CS CG G++ R V C + C + RP E + C + C W +
Sbjct: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGE--PCPTWELS 900
Query: 1095 DWSKCSITCGKGMQSRVIQCM-HKITGRHGNECFSSEKPAAYRPCHLQPC 1143
WS CS +CG+G Q R ++C+ H ++C KP C L+PC
Sbjct: 901 AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 43.1 bits (100), Expect = 0.002
Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 5/55 (9%)
Query: 1091 WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNE 1145
W G W CS +CG G+Q R + C R C AA+RP Q C E
Sbjct: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPAC-----DAAHRPVETQACGE 892
Score = 36.6 bits (83), Expect = 0.15
Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 8/56 (14%)
Query: 1094 GDWSK------CSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
G W+K CS TCG G+Q QC + G C YR C+L+PC
Sbjct: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVR--VKYRSCNLEPC 570
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif, 1
preproprotein [Homo sapiens]
Length = 967
Score = 369 bits (946), Expect = e-101
Identities = 271/922 (29%), Positives = 407/922 (44%), Gaps = 121/922 (13%)
Query: 154 PAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPP 213
P P LR+ AF + L L LR D FLAP F ++ G S + P
Sbjct: 63 PELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQN--------VGRKSGSETP 114
Query: 214 APPD--AGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPL---NDTMAITGH 268
P A CFY+G V P S A+ S C G F L E + FI+PL ++ +A
Sbjct: 115 LPETDLAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAY-FIQPLPAASERLATAAP 173
Query: 269 ------PHRVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKIAES--------GRG 314
P + + +R+ + V CG++ D+ RP + E G
Sbjct: 174 GEKPPAPLQFHLLRRNRQGDV-------GGTCGVVDDEPRPTGKAETEDEDEGTEGEDEG 226
Query: 315 KRYSYKLP---------------------QEYNIETVVVADPAMVSYHGADAARRFILTI 353
++S + P +ET++VAD +M +HG+ + ++LT+
Sbjct: 227 AQWSPQDPALQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGS-GLKHYLLTL 285
Query: 354 LNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKND 413
++ L++H S+ V+L V+K++++H+ + + L +FC WQ + +
Sbjct: 286 FSVAARLYKHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSD- 344
Query: 414 IHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNG 473
D D AIL TR+D C + CDT+G+A + +C R C + ED+G
Sbjct: 345 ----------RDAEHYDTAILFTRQDLC--GSQTCDTLGMADVGTVCDPSRSCSVIEDDG 392
Query: 474 LNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVS----WSRCSKEDL 529
L AFT AHE+GH + HD D CA + + L ++ WS CS +
Sbjct: 393 LQAAFTTAHELGHVFNMPHD-DAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMI 451
Query: 530 ERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICT 589
FL + CL+ PQ N + +P LPG +Y A+ QCQ FG + C + C+
Sbjct: 452 TSFLDNGHGECLMD-KPQ--NPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAAST-CS 507
Query: 590 GLWCKVE--GEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTS-----APEHLAGEWSLW 642
LWC G C+TK P DGT C GKWC G+C ++T P H G W +W
Sbjct: 508 TLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFH--GSWGMW 565
Query: 643 SP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGL-PGFRDWQ 696
P CSRTC G+ R+C P + + C G R +YR C CP FR+ Q
Sbjct: 566 GPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQ 625
Query: 697 CQA---YSVRTSSPKHILQW---QAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGY 750
C+A +S + ++W A + + C L C G +L KV+DGT C
Sbjct: 626 CEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSP 685
Query: 751 QGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVI 810
+C G+C K GCD ++ S + D CGVC GNG +CK I G + GY +++ I
Sbjct: 686 DSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAK-PGYHDIITI 744
Query: 811 PAGARRIKVVE-----EKPAHSYLALRDA-GKQSINSDWKIEH-SGAFNLAGTTVHYV-R 862
P GA I+V + + S+LA++ A G +N D+ + G + Y
Sbjct: 745 PTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGS 804
Query: 863 RGLWEKISAKGPTTAPLHLLVLLFQDQ-NYGLHYEYTIPSDPLPENQSSKAPEPLFMWTH 921
E+I + P PL + VL + + Y Y + + +S A W
Sbjct: 805 SAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKK----KKESFNAIPTFSAWVI 860
Query: 922 TSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWM 981
W +C +C G ++ V C I + S +C KP R C + PC +W
Sbjct: 861 EEWGECSKSCELGWQRRLVECRDINGQPAS-----ECAKEVKP-ASTRPCADHPC-PQWQ 913
Query: 982 MTEWTPCSRTCGKGMQSRQVAC 1003
+ EW+ CS+TCGKG + R + C
Sbjct: 914 LGEWSSCSKTCGKGYKKRSLKC 935
Score = 70.1 bits (170), Expect = 1e-11
Identities = 36/113 (31%), Positives = 54/113 (47%), Gaps = 7/113 (6%)
Query: 1038 TVWEAGVWSECSVKCGKGIRHRTVRCTN----PRKKCVLSTRPREAEDCEDYSKCYVWRM 1093
+ W W ECS C G + R V C + P +C +P C D+ C W++
Sbjct: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHP-CPQWQL 914
Query: 1094 GDWSKCSITCGKGMQSRVIQCMHKITGRHGNE-CFSSEKPAAYRP-CHLQPCN 1144
G+WS CS TCGKG + R ++C+ G +E C +KP + C + C+
Sbjct: 915 GEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS 967
Score = 43.5 bits (101), Expect = 0.001
Identities = 35/121 (28%), Positives = 49/121 (40%), Gaps = 26/121 (21%)
Query: 1036 CMTVWEAGV-------------WSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDC 1082
C T+W G W++ CG+G C N KCV T R+ D
Sbjct: 506 CSTLWCTGTSGGVLVCQTKHFPWAD-GTSCGEG-----KWCING--KCVNKT-DRKHFDT 556
Query: 1083 EDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQP 1142
+ +W G W CS TCG G+Q + +C + + G C K YR C+L+
Sbjct: 557 PFHGSWGMW--GPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYC--EGKRVRYRSCNLED 612
Query: 1143 C 1143
C
Sbjct: 613 C 613
Score = 41.6 bits (96), Expect = 0.005
Identities = 21/72 (29%), Positives = 31/72 (43%), Gaps = 3/72 (4%)
Query: 905 PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKP 964
P + A P W W C TCG G +K ++ C +S + ++ +E C L KP
Sbjct: 898 PASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKC---LSHDGGVLSHESCDPLKKP 954
Query: 965 EPQIRKCNEQPC 976
+ I C C
Sbjct: 955 KHFIDFCTMAEC 966
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 343 bits (879), Expect = 7e-94
Identities = 271/911 (29%), Positives = 415/911 (45%), Gaps = 112/911 (12%)
Query: 132 LSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRF 191
L+ GAPA +P Q P + G E+ L + AF + L L D FLAP F
Sbjct: 23 LARGAPA--RPAAGGQASELVVPTRLPGSAG-ELALHLSAFGKGFVLRLAPDDSFLAPEF 79
Query: 192 AVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNE 251
+E+ G G GCF++G V P SLA+ S C G F+ E
Sbjct: 80 KIERLGGSGRATGGERGL--------RGCFFSGTVNGEPESLAAVSLCRGLSGSFLLDGE 131
Query: 252 DFIFIEPLNDTMAITGHPHRVYR------------------------QKRSMEEKVTEKS 287
+F I+P ++ PHR+ R Q+R ++ +E+
Sbjct: 132 EFT-IQPQGAGGSLA-QPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEE 189
Query: 288 ALHSHYCGIISDKGRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGADAAR 347
+ G S+ P + + R KR+ + + +ET++VAD +M +++GAD +
Sbjct: 190 SQEEEAEGA-SEPPPP----LGATSRTKRF---VSEARFVETLLVADASMAAFYGADL-Q 240
Query: 348 RFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEE 407
ILT++++ +++H S+ +NL V+K++++ + + +G L +FC WQ
Sbjct: 241 NHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRR- 299
Query: 408 FGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCI 467
F + +D H E D AIL+TR++FC ++ CDT+G+A + +C + C
Sbjct: 300 FNQPSDRHPE----------HYDTAILLTRQNFC-GQEGLCDTLGVADIGTICDPNKSCS 348
Query: 468 IAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCA-----DGLHIMSGEWIKGQNLGDVSWS 522
+ ED GL A T+AHE+GH + + HD+ P H+M+ ++ + WS
Sbjct: 349 VIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQT--LPWS 406
Query: 523 RCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMT--YTADEQCQILFGPLASFC 580
CS L L +CLL ++ +P+ LPG Y D+QC+ +FGP C
Sbjct: 407 PCSAMYLTELLDGGHGDCLLDA---PAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHC 463
Query: 581 QEMQ-HVICTGLWCKVEG-EKECRTKLD--PPMDGTDCDLGKWCKAGECT--SRTSAPEH 634
+C LWC +G E C TK P DGT C G C G C P+
Sbjct: 464 PNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKP 523
Query: 635 LA-GEWSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAG 688
+A G W+ W P CSRTC G+ R+C P + R C G R +Y+ C CP
Sbjct: 524 VADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPD 583
Query: 689 LPGFRDWQCQAYSVR--TSSPKHILQW---QAVLDEEKPCALFCSPVGKEQPILLSEKVM 743
FR+ QC+ Y+ T ++LQW A + C LFC G+ + + KV+
Sbjct: 584 GKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVI 643
Query: 744 DGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAG 803
DGT CG + L IC G+C K GCD ++ S + D CGVC G G SC+ + G T G
Sbjct: 644 DGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPT-NYG 702
Query: 804 YVEVLVIPAGARRIKVVEE-----KPAHSYLALRDA-GKQSINSDWKIEH-SGAFNLAGT 856
Y +++ IPAGA I V + + +YLAL+ A G+ +N + I + GT
Sbjct: 703 YNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGT 762
Query: 857 TVHYVRR-GLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYT--IPSDPLPENQSSKAP 913
+ Y E++ + P PL + +L + + +YT +P+D QSSK
Sbjct: 763 ILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKER 822
Query: 914 ------EPLF--MWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPE 965
+PL W W +C +TCG G ++ TV C ++ S + C KPE
Sbjct: 823 ATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVEC-----RDPSGQASATCNKALKPE 877
Query: 966 PQIRKCNEQPC 976
+ C Q C
Sbjct: 878 -DAKPCESQLC 887
Score = 51.6 bits (122), Expect = 4e-06
Identities = 22/53 (41%), Positives = 30/53 (56%), Gaps = 1/53 (1%)
Query: 1091 WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
W +GDWS+CS TCG G Q R ++C +G+ C + KP +PC Q C
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDP-SGQASATCNKALKPEDAKPCESQLC 887
Score = 45.1 bits (105), Expect = 4e-04
Identities = 20/48 (41%), Positives = 27/48 (56%), Gaps = 4/48 (8%)
Query: 1040 WEAGVWSECSVKCGKGIRHRTVRCTNPRKK----CVLSTRPREAEDCE 1083
W G WSECS CG G + RTV C +P + C + +P +A+ CE
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCE 883
Score = 37.0 bits (84), Expect = 0.11
Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 2/50 (4%)
Query: 1094 GDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
G W +CS TCG G+Q +C G C + A Y+ CH + C
Sbjct: 533 GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLG--RRAKYQSCHTEEC 580
Score = 31.6 bits (70), Expect = 4.8
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 8/53 (15%)
Query: 985 WTPCSRTCGKGMQSRQVACTQ-QLSNGTLIRARERDCIGPKPASAQRCEGQDC 1036
W CSRTCG G+Q C + NG R C+G + A Q C ++C
Sbjct: 535 WGECSRTCGGGVQFSHRECKDPEPQNG------GRYCLG-RRAKYQSCHTEEC 580
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 340 bits (871), Expect = 6e-93
Identities = 262/904 (28%), Positives = 385/904 (42%), Gaps = 125/904 (13%)
Query: 127 SGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPD-------------GDEVLLRIPAFS 173
+ AAA P + +PP P P G +V + A
Sbjct: 36 TAAAAAQPRRRQGEEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGG 95
Query: 174 RDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSL 233
R L L RDG F P G T A P + CFY G V P SL
Sbjct: 96 RRFLLDLERDGSVGIAGFV------PAGGGTSA------PWRHRSHCFYRGTVDGSPRSL 143
Query: 234 ASFSTCGGGLMGFIQLNEDFIFIEPL--------------------------NDTMAITG 267
A F CGG L GF + ++PL + +
Sbjct: 144 AVFDLCGG-LDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEA 202
Query: 268 HPHRVYRQKRSMEEKVTEKSALHSHYCG--IISDKGRPRSRKIAESGRG-----KRYSYK 320
P R + + + E + HS+ G ++ + +S G G +R
Sbjct: 203 LPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRRRRRS 262
Query: 321 LPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILL 380
+ + +E ++VAD +M +G + ++LT+ ++ L+ H S+ + L V+K+++L
Sbjct: 263 ISRARQVELLLVADASMARLYGR-GLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVL 321
Query: 381 HETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDF 440
+ L + + L++FCKWQH+ + D H E DAAIL TR+D
Sbjct: 322 GDKDKSLEVSKNAATTLKNFCKWQHQH-NQLGDDHEE----------HYDAAILFTREDL 370
Query: 441 CVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCA 500
C H CDT+G+A + +CS +R C + ED+GL+ AFT+AHE+GH +G++HD D C
Sbjct: 371 CGHHS--CDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHD-DSKFCE 427
Query: 501 DGLHIMSGEWIKGQNLGDVS----WSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPS 556
+ + + L + WS+C+ + FL NCLL + + + P
Sbjct: 428 ETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI---LGPE 484
Query: 557 KLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKV--EGEKECRTKLDPPMDGTDC 614
+LPG TY A +QC + FGP S C M +C LWC V +G+ C TK P ++GT C
Sbjct: 485 ELPGQTYDATQQCNLTFGPEYSVCPGMD--VCARLWCAVVRQGQMVCLTKKLPAVEGTPC 542
Query: 615 DLGKWCKAGECTSRTSAPEHLA------GEWSLWSPCSRTCSAGISSRERKC--PGLDSE 666
G+ C G+C +T + G W W CSR+C G+ R C P +
Sbjct: 543 GKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNN 602
Query: 667 ARDCNGPRKQYRICENPPCPAGLPGFRDWQCQA---YSVRTSSPKHILQWQAVLDEEKP- 722
R C G R YR C PCP FR QC+A Y K ++W P
Sbjct: 603 GRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPA 662
Query: 723 --CALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCG 780
C L C G ++ S KV DGT C +C G+C + GCDG++GS + D CG
Sbjct: 663 DVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCG 722
Query: 781 VCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAH-----SYLALRDA- 834
VC G+ SC I G FN + GY +V+ IP GA IKV + K +YLAL+
Sbjct: 723 VCGGDNSSCTKIVGTFN-KKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKN 781
Query: 835 GKQSINSDWKIEHSGA-FNLAGTTVHYVRRGLW----EKISAKG-PTTAPLHLLVLLFQD 888
G+ IN + I S ++ GT ++Y W + + G T + ++ +L D
Sbjct: 782 GEYLINGKYMISTSETIIDINGTVMNY---SGWSHRDDFLHGMGYSATKEILIVQILATD 838
Query: 889 QNYGL--HYEYTIPSDPLPENQSSKAPEPLFMWTHTS--------WEDCDATCGGGERKT 938
L Y + +P P+ S + + +HTS W C TC G
Sbjct: 839 PTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTR 898
Query: 939 TVSC 942
TV C
Sbjct: 899 TVQC 902
Score = 45.1 bits (105), Expect = 4e-04
Identities = 38/126 (30%), Positives = 48/126 (38%), Gaps = 25/126 (19%)
Query: 1031 CEGQD-CMTVWEAGVWSE---CSVK---------CGKGIRHRTVRCTNPRKKCVLSTRPR 1077
C G D C +W A V C K CGKG +C + KK ST
Sbjct: 508 CPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYST--- 564
Query: 1078 EAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRP 1137
+ W G W +CS +CG G+Q C + +G C + K A YR
Sbjct: 565 -----SSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYC--TGKRAIYRS 615
Query: 1138 CHLQPC 1143
C L PC
Sbjct: 616 CSLMPC 621
Score = 41.6 bits (96), Expect = 0.005
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Query: 1091 WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
W G W CS TC G +R +QC + C S++P+A++ C L+ C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDG-NRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 37.0 bits (84), Expect = 0.11
Identities = 18/47 (38%), Positives = 22/47 (46%), Gaps = 4/47 (8%)
Query: 1040 WEAGVWSECSVKCGKGIRHRTVRCTNPRKK----CVLSTRPREAEDC 1082
W G W CS C G RTV+C + +K C LS RP + C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQC 925
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 309 bits (792), Expect = 9e-84
Identities = 244/793 (30%), Positives = 347/793 (43%), Gaps = 90/793 (11%)
Query: 165 VLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTG 224
+L R+ AF L L L +D V+ AP+ + G + TG
Sbjct: 81 LLCRLQAFGETLLLELEQDSGVQVEGLTVQY----------LGQAPELLGGAEPGTYLTG 130
Query: 225 AVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLND-TMAITGHPHRVYRQKRSMEEKV 283
+ P S+AS GG L+G +Q + ++PL T G P +++S
Sbjct: 131 TINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKS----- 185
Query: 284 TEKSALHSHYCGIISDKGRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGA 343
++ C + + G P R R KR++ +ET+VVAD M ++HGA
Sbjct: 186 --PASGQGPMCNVKAPLGSPSPRP----RRAKRFA---SLSRFVETLVVADDKMAAFHGA 236
Query: 344 DAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKW 403
+R++LT++ F+H S+ V+L V +L++L +G + L SFC W
Sbjct: 237 -GLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAW 295
Query: 404 QHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEK 463
Q ++T D D AIL TR+D C CDT+G+A + +C
Sbjct: 296 QRG-----------LNTPEDSDPDHFDTAILFTRQDLC--GVSTCDTLGMADVGTVCDPA 342
Query: 464 RKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVS--- 520
R C I ED+GL AFT AHE+GH + HDN P + + + + + V
Sbjct: 343 RSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEE 402
Query: 521 -WSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASF 579
WS CS + FL + +CLL P++ + +P PG Y AD QCQ+ FGP +
Sbjct: 403 PWSPCSARFITDFLDNGYGHCLLD-KPEA--PLHLPVTFPGKDYDADRQCQLTFGPDSRH 459
Query: 580 CQEMQHVICTGLWCK--VEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEH--- 634
C ++ C LWC + G C+TK P DGT C + C G C +
Sbjct: 460 CPQLPPP-CAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIP 518
Query: 635 LAGEWSLWSP---CSRTCSAGISSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGL 689
AG W W P CSRTC G+ R C P + + C G R ++R C CP G
Sbjct: 519 QAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGS 578
Query: 690 P-GFRDWQCQAYSVRTSSPKHI---LQWQAVLDEEKP---CALFCSPVGKEQPILLSEKV 742
FR+ QC AY+ RT K + W P C L C +L +V
Sbjct: 579 ALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRV 638
Query: 743 MDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGA 802
+DGT C +C GRC GCD ++GS + D C VC G+G C G F R
Sbjct: 639 VDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR-Y 697
Query: 803 GYVEVLVIPAGARRIKVVEE-KPAHS--YLALR-DAGKQSINSDWKIEHS-------GAF 851
GY V+ IPAGA I V ++ P H YLAL+ G ++N ++ + S GA
Sbjct: 698 GYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAV 757
Query: 852 NL--AGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLF-QDQNYGLHYEYTIPSDPLPENQ 908
+L +G T E +S GP PL L VL+ Q+ L Y + +P P P
Sbjct: 758 SLRYSGAT------AASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPR-PTP--- 807
Query: 909 SSKAPEPLFMWTH 921
S+ P P W H
Sbjct: 808 STPRPTPQ-DWLH 819
Score = 38.9 bits (89), Expect = 0.030
Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 7/60 (11%)
Query: 924 WEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMT 983
W DC TCGGG + ++ CT+ + +N KY + R CN + C T +T
Sbjct: 529 WGDCSRTCGGGVQFSSRDCTRPVPRNGG-------KYCEGRRTRFRSCNTEDCPTGSALT 581
Score = 34.3 bits (77), Expect = 0.74
Identities = 20/70 (28%), Positives = 28/70 (40%), Gaps = 13/70 (18%)
Query: 1094 GDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTIT 1153
G W CS TCG G+Q C + G C + +R C+ + C
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYC--EGRRTRFRSCNTEDC---------- 574
Query: 1154 SPRLAALTFK 1163
P +ALTF+
Sbjct: 575 -PTGSALTFR 583
Score = 30.8 bits (68), Expect = 8.1
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 6/54 (11%)
Query: 985 WTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMT 1038
W CSRTCG G+Q CT+ + R + C G + + C +DC T
Sbjct: 529 WGDCSRTCGGGVQFSSRDCTRPVP-----RNGGKYCEG-RRTRFRSCNTEDCPT 576
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 282 bits (722), Expect = 1e-75
Identities = 219/777 (28%), Positives = 326/777 (41%), Gaps = 65/777 (8%)
Query: 326 NIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPP 385
++E +V P + H D R++LT LN+ L + SL Q + ++K+++L E
Sbjct: 81 HLELLVAVGPDVFQAHQEDT-ERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEG 139
Query: 386 ELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKD 445
I + L S C W I+ E T+ G D + ITR D + D
Sbjct: 140 APNITANLTSSLLSVCGWSQT-------INPEDDTDPGH----ADLVLYITRFDLEL-PD 187
Query: 446 EPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPS-CADGLH 504
G+ L G CS C+I ED G +L TIAHE+GH+ G+ HD S C H
Sbjct: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGH 247
Query: 505 IMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQT-NPQSVNSVMVPSKLPGMTY 563
+M+ + + ++WS CS+ L L + + C+ PQ ++ P PG+ Y
Sbjct: 248 VMASDGAAPR--AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYY 305
Query: 564 TADEQCQILFGPLASFCQ-EMQHV-ICTGLWCKVE--GEKECRTKLDPPMDGTDCDLGKW 619
+A+EQC++ FGP A C +H+ +C L C + + C L P +DGT+C + KW
Sbjct: 306 SANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKW 365
Query: 620 CKAGECTSRTSAPEHLA--GEWSLW---SPCSRTCSAGISSRERKC--PGLDSEARDCNG 672
C G C S A G WS W SPCSR+C G+ +R R+C P R C G
Sbjct: 366 CSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG 425
Query: 673 PRKQYRICENPPCPAGLPGFRDWQCQAYSVRT--SSP--KHILQWQAVLDEEKPCAL--- 725
Q +C C F QC + SSP W A + + AL
Sbjct: 426 ADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRH 485
Query: 726 FCSPVGKEQPILLSEKVMDGTSCGYQG------LDICANGRCQKVGCDGLLGSLAREDHC 779
C +G+ + + +DGT C G L +C +G C+ GCDG + S D C
Sbjct: 486 MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRC 545
Query: 780 GVCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSI 839
VC G+ +C KG F R YV L + + + +P ++LA+R G+ +
Sbjct: 546 QVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVV 605
Query: 840 NSDWKIEHSGAFN--LAGTTVHY------VRRGLWEKISAKGPTTAPLHLLVLLFQDQNY 891
I + + L V Y R E+I GP + V + Y
Sbjct: 606 AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEY 665
Query: 892 GLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWE-DCDATCGGGERKTTVSCTKIMSKNI 950
G T P Q P+P W + C +CG G R SC K
Sbjct: 666 G---NLTRPDITFTYFQ----PKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARK-- 716
Query: 951 SIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNG 1010
+V+ +C+ +P C +PC W + ++ PCS +CG G++ R V C + + G
Sbjct: 717 ELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVE--AQG 774
Query: 1011 TLIR----ARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC 1063
+L++ AR R + + C Q C WE S C+ G G+ C
Sbjct: 775 SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETC 831
Score = 96.7 bits (239), Expect = 1e-19
Identities = 57/174 (32%), Positives = 82/174 (47%), Gaps = 11/174 (6%)
Query: 927 CDATCGGGERKTTVSCTKIMSKNIS--IVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTE 984
C +CG G + + C + ++ I+ + +C+ L +PEPQ C+ +PC RW +
Sbjct: 962 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQ-EACSLEPCPPRWKVMS 1020
Query: 985 WTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQDCMTVWEAG 1043
PCS +CG G R VAC Q L G + E C +P ++ C DC W G
Sbjct: 1021 LGPCSASCGLGTARRSVACVQ-LDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1079
Query: 1044 VWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWS 1097
W ECSV CG GI+ R C P+ + P A+ C+ K R G W+
Sbjct: 1080 TWMECSVSCGDGIQRRRDTCLGPQAQA-----PVPADFCQHLPKPVTVR-GCWA 1127
Score = 94.0 bits (232), Expect = 8e-19
Identities = 67/256 (26%), Positives = 97/256 (37%), Gaps = 21/256 (8%)
Query: 903 PLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISI-VDNEKCKYL 961
P P + +WT + C +CG G + C M + + V E C
Sbjct: 881 PSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLC---MDSALRVPVQEELCGLA 936
Query: 962 TKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLS--NGTLIRARERD 1019
+KP + C PC RW + CS +CG+G+ R + C + +G I +
Sbjct: 937 SKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILL-DTQ 994
Query: 1020 CIG-PKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTN---------PRKK 1069
C G P+P + C + C W+ CS CG G R+V C
Sbjct: 995 CQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAA 1054
Query: 1070 CVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCM--HKITGRHGNECF 1127
C RP + C Y W +G W +CS++CG G+Q R C+ + C
Sbjct: 1055 CAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQ 1114
Query: 1128 SSEKPAAYRPCHLQPC 1143
KP R C PC
Sbjct: 1115 HLPKPVTVRGCWAGPC 1130
Score = 84.7 bits (208), Expect = 5e-16
Identities = 59/276 (21%), Positives = 98/276 (35%), Gaps = 42/276 (15%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKY-LTKPEPQIRKCNEQPCQ 977
W + C A+CGGG R+ V C + + + +C+ +P + CN QPC
Sbjct: 746 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 805
Query: 978 TRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM 1037
RW ++E + C+ G G+ C + K + + C G C
Sbjct: 806 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCP 865
Query: 1038 TVW------------------------EAGVWS----ECSVKCGKGIRHRTVRCTNPRKK 1069
W A VW+ CSV CG+G+ C + +
Sbjct: 866 PGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALR 925
Query: 1070 -------CVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRH 1122
C L+++P + C + CS++CG+G+ R++ C
Sbjct: 926 VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDD 985
Query: 1123 GNE------CFSSEKPAAYRPCHLQPCNEKINVNTI 1152
G E C +P C L+PC + V ++
Sbjct: 986 GEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSL 1021
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 282 bits (722), Expect = 1e-75
Identities = 219/777 (28%), Positives = 326/777 (41%), Gaps = 65/777 (8%)
Query: 326 NIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPP 385
++E +V P + H D R++LT LN+ L + SL Q + ++K+++L E
Sbjct: 81 HLELLVAVGPDVFQAHQEDT-ERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEG 139
Query: 386 ELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKD 445
I + L S C W I+ E T+ G D + ITR D + D
Sbjct: 140 APNITANLTSSLLSVCGWSQT-------INPEDDTDPGH----ADLVLYITRFDLEL-PD 187
Query: 446 EPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPS-CADGLH 504
G+ L G CS C+I ED G +L TIAHE+GH+ G+ HD S C H
Sbjct: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGH 247
Query: 505 IMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQT-NPQSVNSVMVPSKLPGMTY 563
+M+ + + ++WS CS+ L L + + C+ PQ ++ P PG+ Y
Sbjct: 248 VMASDGAAPR--AGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYY 305
Query: 564 TADEQCQILFGPLASFCQ-EMQHV-ICTGLWCKVE--GEKECRTKLDPPMDGTDCDLGKW 619
+A+EQC++ FGP A C +H+ +C L C + + C L P +DGT+C + KW
Sbjct: 306 SANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKW 365
Query: 620 CKAGECTSRTSAPEHLA--GEWSLW---SPCSRTCSAGISSRERKC--PGLDSEARDCNG 672
C G C S A G WS W SPCSR+C G+ +R R+C P R C G
Sbjct: 366 CSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG 425
Query: 673 PRKQYRICENPPCPAGLPGFRDWQCQAYSVRT--SSP--KHILQWQAVLDEEKPCAL--- 725
Q +C C F QC + SSP W A + + AL
Sbjct: 426 ADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRH 485
Query: 726 FCSPVGKEQPILLSEKVMDGTSCGYQG------LDICANGRCQKVGCDGLLGSLAREDHC 779
C +G+ + + +DGT C G L +C +G C+ GCDG + S D C
Sbjct: 486 MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRC 545
Query: 780 GVCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSI 839
VC G+ +C KG F R YV L + + + +P ++LA+R G+ +
Sbjct: 546 QVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVV 605
Query: 840 NSDWKIEHSGAFN--LAGTTVHY------VRRGLWEKISAKGPTTAPLHLLVLLFQDQNY 891
I + + L V Y R E+I GP + V + Y
Sbjct: 606 AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEY 665
Query: 892 GLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWE-DCDATCGGGERKTTVSCTKIMSKNI 950
G T P Q P+P W + C +CG G R SC K
Sbjct: 666 G---NLTRPDITFTYFQ----PKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARK-- 716
Query: 951 SIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNG 1010
+V+ +C+ +P C +PC W + ++ PCS +CG G++ R V C + + G
Sbjct: 717 ELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVE--AQG 774
Query: 1011 TLIR----ARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC 1063
+L++ AR R + + C Q C WE S C+ G G+ C
Sbjct: 775 SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETC 831
Score = 97.1 bits (240), Expect = 9e-20
Identities = 61/188 (32%), Positives = 88/188 (46%), Gaps = 13/188 (6%)
Query: 927 CDATCGGGERKTTVSCTKIMSKNIS--IVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTE 984
C +CG G + + C + ++ I+ + +C+ L +PEPQ C+ +PC RW +
Sbjct: 962 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQ-EACSLEPCPPRWKVMS 1020
Query: 985 WTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQDCMTVWEAG 1043
PCS +CG G R VAC Q L G + E C +P ++ C DC W G
Sbjct: 1021 LGPCSASCGLGTARRSVACVQ-LDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1079
Query: 1044 VWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITC 1103
W ECSV CG GI+ R C P+ + P A+ C+ K R G W+ +
Sbjct: 1080 TWMECSVSCGDGIQRRRDTCLGPQAQA-----PVPADFCQHLPKPVTVR-GCWAGPCV-- 1131
Query: 1104 GKGMQSRV 1111
G+G S V
Sbjct: 1132 GQGTPSLV 1139
Score = 94.0 bits (232), Expect = 8e-19
Identities = 67/256 (26%), Positives = 97/256 (37%), Gaps = 21/256 (8%)
Query: 903 PLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISI-VDNEKCKYL 961
P P + +WT + C +CG G + C M + + V E C
Sbjct: 881 PSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLC---MDSALRVPVQEELCGLA 936
Query: 962 TKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLS--NGTLIRARERD 1019
+KP + C PC RW + CS +CG+G+ R + C + +G I +
Sbjct: 937 SKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILL-DTQ 994
Query: 1020 CIG-PKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTN---------PRKK 1069
C G P+P + C + C W+ CS CG G R+V C
Sbjct: 995 CQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAA 1054
Query: 1070 CVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCM--HKITGRHGNECF 1127
C RP + C Y W +G W +CS++CG G+Q R C+ + C
Sbjct: 1055 CAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQ 1114
Query: 1128 SSEKPAAYRPCHLQPC 1143
KP R C PC
Sbjct: 1115 HLPKPVTVRGCWAGPC 1130
Score = 84.7 bits (208), Expect = 5e-16
Identities = 59/276 (21%), Positives = 98/276 (35%), Gaps = 42/276 (15%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKY-LTKPEPQIRKCNEQPCQ 977
W + C A+CGGG R+ V C + + + +C+ +P + CN QPC
Sbjct: 746 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 805
Query: 978 TRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM 1037
RW ++E + C+ G G+ C + K + + C G C
Sbjct: 806 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCP 865
Query: 1038 TVW------------------------EAGVWS----ECSVKCGKGIRHRTVRCTNPRKK 1069
W A VW+ CSV CG+G+ C + +
Sbjct: 866 PGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALR 925
Query: 1070 -------CVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRH 1122
C L+++P + C + CS++CG+G+ R++ C
Sbjct: 926 VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDD 985
Query: 1123 GNE------CFSSEKPAAYRPCHLQPCNEKINVNTI 1152
G E C +P C L+PC + V ++
Sbjct: 986 GEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSL 1021
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 281 bits (720), Expect = 2e-75
Identities = 181/536 (33%), Positives = 235/536 (43%), Gaps = 81/536 (15%)
Query: 637 GEWSLWSPCSRTCSAGISSRERKCPGLDSEARD----CNGPRKQYRICENPPCPAGLPGF 692
G WS WSPCSRTC G+S RER C S+ RD C GP + +R C CP G F
Sbjct: 30 GPWSQWSPCSRTCGGGVSFRERPCY---SQRRDGGSSCVGPARSHRSCRTESCPDGARDF 86
Query: 693 RDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQG 752
R QC + + +W C L C P G+ E V+DGT C
Sbjct: 87 RAEQCAEFDGAEFQGRRY-RWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGK 145
Query: 753 LDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPA 812
D+C +G C+ VGCD L S +ED C C G+G +C + G F+
Sbjct: 146 RDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDAN------------D 193
Query: 813 GARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAGTTVHYVRRG----LWEK 868
+R +K V G+ +N W IE + A A T +HY R E+
Sbjct: 194 LSRAVKNVR-------------GEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPER 240
Query: 869 ISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCD 928
+ A+GPT+ PL ++ L+ Q+ N G+HYEY +P + P P F W+H SW DC
Sbjct: 241 LHARGPTSEPL-VIELISQEPNPGVHYEYHLP---------LRRPSPGFSWSHGSWSDCS 290
Query: 929 ATCGGGERKTTVSCTKIMSKNISIVDNE-----KCKYLTKPEPQIRKCNEQPC--QTRWM 981
A CGGG + V CT +D+E C+ +P + R CN PC RW
Sbjct: 291 AECGGGHQSRLVFCT---------IDHEAYPDHMCQRQPRPADR-RSCNLHPCPETKRWK 340
Query: 982 MTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG--PKPASAQRCEGQDCMTV 1039
W PCS +CG G QSR V C G E +C G KP + Q C Q C
Sbjct: 341 AGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-AA 399
Query: 1040 WEAGVWSECSVKCGKGIRHRTVRCTNPR------KKCVLSTRPREAEDCEDYSKC----- 1088
W W ECSV CG G+R R+V C R C L RP E C + C
Sbjct: 400 WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV-HEDCPLLSD 458
Query: 1089 YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCN 1144
W +G W CS +C G + R + C G+ KP PC+ QPC+
Sbjct: 459 QAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGS--LQHSKPVDVEPCNTQPCH 512
Score = 49.3 bits (116), Expect = 2e-05
Identities = 22/57 (38%), Positives = 28/57 (49%)
Query: 1089 YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNE 1145
+ W G WS CS CG G QSR++ C + C +PA R C+L PC E
Sbjct: 279 FSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPE 335
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 275 bits (703), Expect = 2e-73
Identities = 181/594 (30%), Positives = 269/594 (45%), Gaps = 100/594 (16%)
Query: 626 TSRTSAPEH----LAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICE 681
+SRT+ E L W WS CSRTC G S R+C ++ C G +YR C
Sbjct: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC----LSSKSCEGRNIRYRTCS 77
Query: 682 NPPCPAGLPGFRDWQCQAYSVRTSSPKH---ILQWQAVL-DEEKPCALFCSPVGKEQPIL 737
N CP FR QC A++ KH +W V D + PC+L C G +
Sbjct: 78 NVDCPPEAGDFRAQQCSAHN----DVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVE 133
Query: 738 LSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFN 797
L+ KV+DGT C + LD+C +G CQ VGCD LGS +ED+CGVCNG+G +C++++G +
Sbjct: 134 LAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYK 193
Query: 798 HTRGAGYVE--VLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAG 855
A + V+ IP G+R I++V + P H YL + Q + + +G F +
Sbjct: 194 SQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTL--QGTKGENSLSSTGTFLVDN 251
Query: 856 TTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEP 915
++V + + E + GP TA + + + + + + P
Sbjct: 252 SSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPI-------------- 297
Query: 916 LFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLT---KPEPQIRKCN 972
+ W T + C ATCGGG + T+ C + S + V ++ C Y KP+P++++CN
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRV--VADQYCHYYPENIKPKPKLQECN 355
Query: 973 EQPCQT-----------------RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRA 1015
PC RW T WT CS +CG G+QSR V+C ++ G +
Sbjct: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
Query: 1016 RERDCI-GPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKK----C 1070
E C+ PK AQ C DC W A WS C+V CG+G+R+R V C + R C
Sbjct: 416 EEWKCMYTPKMPIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
Query: 1071 VLSTRPREAEDCEDYSKCYVWRMG-------------------------------DWSKC 1099
T+P E+C + CY + WS C
Sbjct: 475 SPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSAC 534
Query: 1100 SITCGKGMQSRVIQCM------HKITGRHGNECFSSEKPAAYRPCHLQPCNEKI 1147
++TCG G Q R+++C + +EC KPA+ R C+ PC+ +I
Sbjct: 535 TVTCGVGTQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPCSGEI 587
Score = 142 bits (359), Expect = 1e-33
Identities = 82/264 (31%), Positives = 123/264 (46%), Gaps = 22/264 (8%)
Query: 914 EPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNE 973
+ L+ W + + C +CGGG ++ VSC ++ + + C +P ++ CN
Sbjct: 606 DELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPA--EENLCVTSRRPPQLLKSCNL 663
Query: 974 QPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLS---NGTLIRARERDCIGPKPASAQR 1030
PC RW + +W+PCS TCG G+Q+R V C+ LS N T+I A E C PKP++ Q
Sbjct: 664 DPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADEL-CRQPKPSTVQA 722
Query: 1031 CEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTN----------PRKKCVLSTRPREAE 1080
C +C W W CS CG G++ R V C P C S +P +
Sbjct: 723 CNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS-KPACQQ 781
Query: 1081 DCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKI-----TGRHGNECFSSEKPAAY 1135
C+ W + DW++CS +CG+G Q+R C + T + C ++
Sbjct: 782 ACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI 841
Query: 1136 RPCHLQPCNEKINVNTITSPRLAA 1159
RPC L C +T SP +AA
Sbjct: 842 RPCMLATCARPGRPSTKHSPHIAA 865
Score = 139 bits (349), Expect = 2e-32
Identities = 83/294 (28%), Positives = 134/294 (45%), Gaps = 38/294 (12%)
Query: 917 FMWTHTSWEDCDATCGG-GERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQP 975
+ W+ C A+CG G ++ + C N + V+ C +P Q CN +
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLL----NSTEVNPAHCAGKVRPAVQPIACNRRD 1544
Query: 976 CQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC--IGPKPASAQRCEG 1033
C +RWM+T W+ C+R+CG G+Q+R+V C + ++G C + +P Q C
Sbjct: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
Query: 1034 QDCMTVWEAGVWSECSVKC---GKGIRHRTVRC------TNPRKKCVLSTRPREAEDCED 1084
Q C+ W W +C+ C ++HR V C T P ++C RP ++C
Sbjct: 1605 QLCVE-WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWS 1663
Query: 1085 YSKCYVWRMGDWSKCSITCGK-GMQSRVIQCMHKITGRHGNE--CFSSEKPAAYRPCHLQ 1141
+ WR+ W+ C+ TCG G QSR ++C+H T + E C +PA ++ C++
Sbjct: 1664 EACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
Query: 1142 PCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETC 1195
PC E + T YC +++ LCQ ++ RCC TC
Sbjct: 1724 PC-ENMECRDTTR-----------------YCEKVKQLKLCQLSQFKSRCCGTC 1759
Score = 107 bits (268), Expect = 5e-23
Identities = 86/314 (27%), Positives = 128/314 (40%), Gaps = 76/314 (24%)
Query: 902 DPLPENQSSKAP------EPLFMWTHTSWEDCDATCGGGERKTTVSCTKI-MSKNISIVD 954
DP P + K PL W T W C ++CGGG + VSC + + +++ V+
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 955 NEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVAC-------TQQL 1007
KC Y K P + CN C +W+ EW+PC+ TCG+G++ R V C T
Sbjct: 417 EWKCMYTPKM-PIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
Query: 1008 SNGTLIRARERDCIGPKPA-----------------SAQRCEGQDCMTVWEAGV---WSE 1047
S T +E +CI P P AQ E ++ + + WS
Sbjct: 475 SPKTKPHIKE-ECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSA 533
Query: 1048 CSVKCGKGIRHRTVRCTN-----------PRKKCVLSTRPREAEDC-------------- 1082
C+V CG G + R VRC P +C +P C
Sbjct: 534 CTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE-GPKPASQRACYAGPCSGEIPEFNP 592
Query: 1083 ----------EDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE--CFSSE 1130
+D+ + Y W ++KCS +CG G+Q V+ C++K T E C +S
Sbjct: 593 DETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSR 652
Query: 1131 K-PAAYRPCHLQPC 1143
+ P + C+L PC
Sbjct: 653 RPPQLLKSCNLDPC 666
Score = 36.6 bits (83), Expect = 0.15
Identities = 38/159 (23%), Positives = 55/159 (34%), Gaps = 50/159 (31%)
Query: 598 EKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRE 657
E C T PP L K C C +R E WSPCS TC G+ +R+
Sbjct: 645 ENLCVTSRRPPQ------LLKSCNLDPCPARW--------EIGKWSPCSLTCGVGLQTRD 690
Query: 658 RKCPGLDSEARD---------CNGPR-KQYRICENPPCPAGLPGFRDWQCQAYSVRTSSP 707
C L S + C P+ + C CP W
Sbjct: 691 VFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPA------W------------ 732
Query: 708 KHILQWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGT 746
+ QWQ PC+ C +++ +L +++ DG+
Sbjct: 733 -YPAQWQ-------PCSRTCGGGVQKREVLCKQRMADGS 763
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 273 bits (699), Expect = 6e-73
Identities = 181/586 (30%), Positives = 258/586 (44%), Gaps = 100/586 (17%)
Query: 634 HLAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCPAGLPGFR 693
H + WSL++P S C+G +Q R C PCP P R
Sbjct: 347 HASSLWSLFAP-------------------SSPIPRCSGESEQLRACSQAPCPPEQPDPR 387
Query: 694 DWQCQAYSVRTSSPKHILQWQAVLDEE--KPCALFCSPVGKEQPILLSEKVMDGTSCGYQ 751
QC A++ + + + QW+ + + + C L C P G + +EKV DGT C
Sbjct: 388 ALQCAAFNSQEFMGQ-LYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPG 446
Query: 752 GLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRG-AGYVEVLVI 810
DIC GRC GCDG+LGS R D CGVC G+ +C+++ G+ G GY ++L I
Sbjct: 447 APDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWI 506
Query: 811 PAGARRIKVVEEKPAHSYLALRDAGKQS-INSDWKIEHSGAFNLAGTTVHYVR----RGL 865
PAGA R+++ + +P+ +YLALR G +S IN +W ++ G++ GT Y R G
Sbjct: 507 PAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGK 566
Query: 866 WEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPS-DPLPENQSSKAP----------- 913
E +SA+GPTT P+ + ++FQ++N G+ Y+Y I S P+ EN + + P
Sbjct: 567 GESLSAEGPTTQPVD-VYMIFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRV 625
Query: 914 -------------------------------------EPLFMWTHTSWEDCDATCGGGER 936
P W C A+CG G
Sbjct: 626 EPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVW 685
Query: 937 KTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGM 996
+ C I ++ +D C +P C+ PC W EWT CSR+CG G
Sbjct: 686 RPIFLC--ISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGT 743
Query: 997 QSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAG-VWSECSVKCGKG 1055
Q RQ+ C Q+ G ER P+P Q C+ + C WE G WS+CSV+CG+G
Sbjct: 744 QHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-GHWEVGSPWSQCSVRCGRG 802
Query: 1056 IRHRTVRCTN------PRKKCVLS-TRPREAEDCEDYSKCYVWRMGDW-SKCSITCGKGM 1107
R R VRC ++C +P E C+ W DW SKCS CG G+
Sbjct: 803 QRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGI 862
Query: 1108 QSRVIQCM----------HKITGRHGNECFSSEKPAAYRPCHLQPC 1143
Q R + C+ + G C + +P R C L PC
Sbjct: 863 QRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPC 908
Score = 122 bits (305), Expect = 3e-27
Identities = 91/333 (27%), Positives = 133/333 (39%), Gaps = 44/333 (13%)
Query: 900 PSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCK 959
P+ P P + + P W W C +CG G + + C + S V E+C
Sbjct: 712 PASPEPCHGTPCPP----YWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG 767
Query: 960 YLTKPEPQI-RKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARER 1018
+L P P I + C + C + + W+ CS CG+G +SRQV C +NG + +E
Sbjct: 768 HL--PRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVG--NNGDEVSEQEC 823
Query: 1019 DCIGPKPASAQRCEGQDCMTVWEAGVWS-ECSVKCGKGIRHRTVRC-------------- 1063
P+P S + C+ C T W WS +CS +CG GI+ R+V C
Sbjct: 824 ASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEA 883
Query: 1064 -TNPRKKCVLSTRPREAEDCE--DYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITG 1120
+ C +RP + C + + W G W +CS CG G Q R I C+ K+
Sbjct: 884 GAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGT 943
Query: 1121 RHG----NECFSSEKPAAYRPCHLQ------------PCNEKINVNTITSPRLAALTFKC 1164
+ C +P A +PC Q PC+ T T T +
Sbjct: 944 EFNVTSPSNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQT 1003
Query: 1165 LGDQWPVYCRVIREKNLCQDMRWYQRCCETCRD 1197
L + P R R K C QR + C+D
Sbjct: 1004 LSTRCPPQLRPSR-KRPCNSQPCSQRPDDQCKD 1035
Score = 117 bits (294), Expect = 5e-26
Identities = 78/306 (25%), Positives = 118/306 (38%), Gaps = 45/306 (14%)
Query: 924 WEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMT 983
W C CG G+R V C + N V ++C P C+ PC T W +
Sbjct: 792 WSQCSVRCGRGQRSRQVRC---VGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHS 848
Query: 984 EWTP-CSRTCGKGMQSRQVACTQQLSNGTLIRARERDC---------IGPKPASAQRCEG 1033
+W+ CS CG G+Q R V C L +G + + + G +P + C
Sbjct: 849 DWSSKCSAECGTGIQRRSVVC---LGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSL 905
Query: 1034 QDCMTVWE--AGVWSECSVKCGKGIRHRTVRC----------TNPRKKCVLSTRPREAED 1081
C W G W ECS +CG G + R + C T+P C RP +
Sbjct: 906 GPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSP-SNCSHLPRPPALQP 964
Query: 1082 CEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQ 1141
C+ + W WS CS +C G Q+R +QC+ C +P+ RPC+ Q
Sbjct: 965 CQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCL-STNQTLSTRCPPQLRPSRKRPCNSQ 1023
Query: 1142 PCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYAQ 1201
PC+++ + S +C ++ + LC + CC +C +
Sbjct: 1024 PCSQRPDDQCKDSSP---------------HCPLVVQARLCVYPYYTATCCRSCAHVLER 1068
Query: 1202 KLQQKS 1207
Q S
Sbjct: 1069 SPQDPS 1074
Score = 36.2 bits (82), Expect = 0.19
Identities = 13/35 (37%), Positives = 17/35 (48%)
Query: 626 TSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC 660
T PE + G W W+ CS+ C G+ R R C
Sbjct: 37 TEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
Score = 34.7 bits (78), Expect = 0.56
Identities = 16/47 (34%), Positives = 23/47 (48%), Gaps = 3/47 (6%)
Query: 642 WSPCSRTCSAGISSRERKCPGLDSEARDCNGPR---KQYRICENPPC 685
WSPCSR+C G +RE +C + P+ + R C + PC
Sbjct: 979 WSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPC 1025
Score = 31.2 bits (69), Expect = 6.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 1032 EGQDCMTVWEAGV-WSECSVKCGKGIRHRTVRCTNP 1066
EGQ VW V W+ CS CG G++ R+ C P
Sbjct: 39 EGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 265 bits (678), Expect = 2e-70
Identities = 182/594 (30%), Positives = 261/594 (43%), Gaps = 104/594 (17%)
Query: 626 TSR-TSAPEHLAGEWSLW---SPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICE 681
TSR T + E G W W S CSRTC G S R+C R+C G +Y+ C
Sbjct: 64 TSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRC----LTGRNCEGQNIRYKTCS 119
Query: 682 NPPCPAGLPGFRDWQCQAYSVRTSSPKHILQW-QAVLDEEKPCALFCSPVGKEQPILLSE 740
N CP FR QC AY+ H +W D PCAL C G+ + L+
Sbjct: 120 NHDCPPDAEDFRAQQCSAYN-DVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAP 178
Query: 741 KVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDF-NHT 799
KV+DGT C LD+C +G CQ VGCD LGS A+ED+CGVC G+G +C++++G +H
Sbjct: 179 KVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHV 238
Query: 800 RGAGYVE-VLVIPAGARRIKVVEEKPAHSYLALR----DAGKQSINSDWKIEHSGAFNLA 854
E V+ +P G+R +++ + PAH ++ + G+ S NS G F +
Sbjct: 239 SPEKREENVIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNS------PGVFLVE 292
Query: 855 GTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPE 914
TTV + R + GP A ++ YT D + + +
Sbjct: 293 NTTVEFQRGSERQTFKIPGPLMA------------DFIFKTRYTAAKDSVVQ---FFFYQ 337
Query: 915 PL-FMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYL---TKPEPQIRK 970
P+ W T + C TCGGG + + C I K +V + C Y KP+P++++
Sbjct: 338 PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKR--VVPDHYCHYYPENVKPKPKLKE 395
Query: 971 CNEQPCQT-----------------RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLI 1013
C+ PC + RW WT CS +CG G+Q R C ++ +G ++
Sbjct: 396 CSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEIL 455
Query: 1014 RARERDCI-GPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVL 1072
+ E C+ PKP Q C DC W A WS+C+V CG+G+R+R V C N R + V
Sbjct: 456 QVEEWKCMYAPKPKVMQTCNLFDC-PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVG 514
Query: 1073 STRPR----EAEDCEDYSKCY-------------------------------VWRMGDWS 1097
P+ E+C CY + WS
Sbjct: 515 GCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWS 574
Query: 1098 KCSITCGKGMQSRVIQCMHKITGRH------GNECFSSEKPAAYRPCHLQPCNE 1145
CS TCG G+Q R ++C +T EC + P RPC L+ C+E
Sbjct: 575 ACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTE-RPCLLEACDE 627
Score = 142 bits (359), Expect = 1e-33
Identities = 97/345 (28%), Positives = 142/345 (41%), Gaps = 48/345 (13%)
Query: 872 KGPTTAPLHLLVLLFQDQNYGL---HYEYTIPSDPLPENQSSKAPEPLFM---WTHTSWE 925
K T+ LHLL + + H +Y + + N + EP W +W
Sbjct: 1375 KAVATSVLHLLERRWPESRIVFLQGHKKYILQATNTRTNSNDPTGEPPPQEPFWEPGNWS 1434
Query: 926 DCDATCGG-GERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTE 984
C ATCG G R C + +S C +L KP CN + C RW +
Sbjct: 1435 HCSATCGHLGARIQRPQCVMANGQEVS---EALCDHLQKPLAGFEPCNIRDCPARWFTSV 1491
Query: 985 WTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPK--PASAQRCEGQDCMTVWEA 1042
W+ CS +CG+G SRQV C + +NGT+ R C PK P + C G C+ WE
Sbjct: 1492 WSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC-APKDRPLGRKPCFGHPCVQ-WEP 1549
Query: 1043 GVWSECSVKC-GKGI----RHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWS 1097
G + C +C G+ + RH + + C RP +C + W G W
Sbjct: 1550 G--NRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCWHTGPWK 1607
Query: 1098 KCSITCGKGMQSRVIQCMH-----KITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTI 1152
C+ CG+G QSR + C+H + RH C +KP ++R C C+ T
Sbjct: 1608 PCTAACGRGFQSRKVDCIHTRSCKPVAKRH---CVQKKKPISWRHCLGPSCDRDCTDTT- 1663
Query: 1153 TSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRD 1197
YC ++ NLC R+ QRCC++C++
Sbjct: 1664 ------------------HYCMFVKHLNLCSLDRYKQRCCQSCQE 1690
Score = 123 bits (308), Expect = 1e-27
Identities = 70/221 (31%), Positives = 99/221 (44%), Gaps = 20/221 (9%)
Query: 903 PLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLT 962
PLPE+ E + W + + C ATC GG ++ C I ++ V++ C +
Sbjct: 637 PLPEDS-----ETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQT--VNDSLCDMVH 689
Query: 963 KPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG 1022
+P + CN +PC RW + W PCS TCG G+Q+R V C L G A +C
Sbjct: 690 RPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYC---LHPGE-TPAPPEECRD 745
Query: 1023 PKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC---------TNPRKKCVLS 1073
KP + Q C DC W W +CS CG G ++R V C N +
Sbjct: 746 EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQG 805
Query: 1074 TRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQC 1114
+ + C +GDWSKCS++CG G+Q R C
Sbjct: 806 PKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
Score = 101 bits (252), Expect = 4e-21
Identities = 70/263 (26%), Positives = 106/263 (40%), Gaps = 41/263 (15%)
Query: 914 EPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMS--KNISIVDNEKC---KYLTKPEPQI 968
EP F+ W C TCG G + V C +++ + + + E+C K T+ +
Sbjct: 565 EPTFI--PEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLL 622
Query: 969 RKCNEQPCQTR--------------WMMTEWTPCSRTCGKGMQSRQVAC----TQQLSNG 1010
C+E P W +TPC+ TC G Q C TQQ N
Sbjct: 623 EACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVND 682
Query: 1011 TLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRK-- 1068
+L D + PA +Q C + C W G W CS CG GI+ R V C +P +
Sbjct: 683 SLC-----DMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETP 737
Query: 1069 ----KCVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITG---- 1120
+C +P + C + W + +W +CS TCG G Q+R + C +T
Sbjct: 738 APPEEC-RDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFL 796
Query: 1121 RHGNECFSSEKPAAYRPCHLQPC 1143
+E K ++++ C C
Sbjct: 797 NLSDELCQGPKASSHKSCARTDC 819
Score = 81.6 bits (200), Expect = 4e-15
Identities = 68/279 (24%), Positives = 105/279 (37%), Gaps = 55/279 (19%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTK----PEPQIRKCNEQ 974
W W C TCG G R V C +++ + + ++ + P P + +
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKS 541
Query: 975 PCQTR--WMM-----------TE--------WTPCSRTCGKGMQSRQVACTQQLS-NGTL 1012
P + + W+ TE W+ CS TCG G+Q R+V C L+ T
Sbjct: 542 PVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTE 601
Query: 1013 IRARERDCIGPKPASAQRC-------------------EGQDCMTVWEAGVWSECSVKCG 1053
E +C GPK + + C E + WE ++ C+ C
Sbjct: 602 TELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCV 661
Query: 1054 KGIRHRTVRCTNPRKK-------CVLSTRPREAEDCEDYSKCYV-WRMGDWSKCSITCGK 1105
G + C + + + C + RP + C W +G W CS TCG
Sbjct: 662 GGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGV 721
Query: 1106 GMQSRVIQCMHK-ITGRHGNECFSSEKPAAYRPCHLQPC 1143
G+Q+R + C+H T EC EKP A + C+ C
Sbjct: 722 GIQTRDVYCLHPGETPAPPEEC-RDEKPHALQACNQFDC 759
Score = 58.5 bits (140), Expect = 4e-08
Identities = 36/139 (25%), Positives = 62/139 (44%), Gaps = 11/139 (7%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISI-VDNEKCKYLTKPEPQIRK-CNEQPC 976
W W+ C TCGGG + V+C ++++ + + +E C+ P+ K C C
Sbjct: 763 WHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQ---GPKASSHKSCARTDC 819
Query: 977 QTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQD 1035
+ +W+ CS +CG G+Q R+ C + + G I E C P + C+ +
Sbjct: 820 PPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPE 879
Query: 1036 CMTVWEAGVWSECSVKCGK 1054
C + + SE K G+
Sbjct: 880 C-----SKIKSEMKTKLGE 893
Score = 35.8 bits (81), Expect = 0.25
Identities = 65/252 (25%), Positives = 97/252 (38%), Gaps = 41/252 (16%)
Query: 627 SRTSAPEHLA-GEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPC 685
+RT P HLA G+WS CS +C GI R++ C L ++ R P + +C + P
Sbjct: 815 ARTDCPPHLAVGDWS---KCSVSCGVGIQRRKQVCQRLAAKGRRI--PLSE-MMCRDLP- 867
Query: 686 PAGLPGFRDWQCQAYSVRTSSPK--------HILQWQAVLDEEKPCALFCSPVGKEQPIL 737
GLP R Q S S K IL Q V + + +G +L
Sbjct: 868 --GLPLVRSCQMPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRINLTIGSRAYLL 925
Query: 738 LSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFN 797
+ V + C R QK SL + + G C N K I K
Sbjct: 926 PNTSV----------IIKCPVRRFQK--------SLIQWEKDGRCLQNSKRLGITKSGSL 967
Query: 798 HTRGAGYVEVLV---IPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLA 854
G ++ V I A+ V++ + L R A ++ + ++HS A N
Sbjct: 968 KIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEA-NSL 1026
Query: 855 GTTVHYVRRGLW 866
G T H +R+ +W
Sbjct: 1027 GVTWHKMRQ-MW 1037
Score = 33.9 bits (76), Expect = 0.96
Identities = 22/76 (28%), Positives = 30/76 (39%), Gaps = 8/76 (10%)
Query: 625 CTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC--PG-LDSEARDCNGPRKQ-YRIC 680
C + P G W PCS TC GI +R+ C PG + +C + + C
Sbjct: 698 CNTEPCPPRWHVGSWG---PCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQAC 754
Query: 681 ENPPCPAGLPGFRDWQ 696
CP G +WQ
Sbjct: 755 NQFDCPPGW-HIEEWQ 769
Score = 33.1 bits (74), Expect = 1.6
Identities = 19/62 (30%), Positives = 25/62 (40%), Gaps = 9/62 (14%)
Query: 642 WSPCSRTCSAGISSRERKCPGLDSEA-------RDCNGPR-KQYRICENPPCPAGLPGFR 693
W CSRTC G +R C L ++ C GP+ ++ C CP L
Sbjct: 768 WQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHL-AVG 826
Query: 694 DW 695
DW
Sbjct: 827 DW 828
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 259 bits (661), Expect = 1e-68
Identities = 211/776 (27%), Positives = 312/776 (40%), Gaps = 94/776 (12%)
Query: 326 NIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPP 385
++E +V P + H D R++LT LN+ L + SL Q + ++K+++L E
Sbjct: 81 HLELLVAVGPDVFQAHQEDT-ERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEG 139
Query: 386 ELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKD 445
I + L S C W I+ E T+ G D + ITR D + D
Sbjct: 140 APNITANLTSSLLSVCGWSQT-------INPEDDTDPGH----ADLVLYITRFDLEL-PD 187
Query: 446 EPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPS-CADGLH 504
G+ L G CS C+I ED G +L TIAHE+GH+ G+ HD S C H
Sbjct: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGH 247
Query: 505 IMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYT 564
+M+ + + ++WS CS+ L L +
Sbjct: 248 VMASDGAAPR--AGLAWSPCSRRQLLSLL------------------------------S 275
Query: 565 ADEQCQILFGPLASFCQ-EMQHV-ICTGLWCKVE--GEKECRTKLDPPMDGTDCDLGKWC 620
A+EQC++ FGP A C +H+ +C L C + + C L P +DGT+C + KWC
Sbjct: 276 ANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWC 335
Query: 621 KAGECTSRTSAPEHLA--GEWSLW---SPCSRTCSAGISSRERKC--PGLDSEARDCNGP 673
G C S A G WS W SPCSR+C G+ +R R+C P R C G
Sbjct: 336 SKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGA 395
Query: 674 RKQYRICENPPCPAGLPGFRDWQCQAYSVR--TSSP--KHILQWQAVLDEEKP---CALF 726
Q +C C F QC + SSP W A + + C
Sbjct: 396 DLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHM 455
Query: 727 CSPVGKEQPILLSEKVMDGTSCGYQG------LDICANGRCQKVGCDGLLGSLAREDHCG 780
C +G+ + + +DGT C G L +C +G C+ GCDG + S D C
Sbjct: 456 CRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQ 515
Query: 781 VCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSIN 840
VC G+ +C KG F R YV L + + + +P ++LA+R G+ +
Sbjct: 516 VCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVA 575
Query: 841 SDWKIEHSGAFN--LAGTTVHY------VRRGLWEKISAKGPTTAPLHLLVLLFQDQNYG 892
I + + L V Y R E+I GP + V + YG
Sbjct: 576 GKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYG 635
Query: 893 LHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWE-DCDATCGGGERKTTVSCTKIMSKNIS 951
T P Q P+P W + C +CG G R SC K
Sbjct: 636 ---NLTRPDITFTYFQ----PKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARK--E 686
Query: 952 IVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGT 1011
+V+ +C+ +P C +PC W + ++ PCS +CG G++ R V C + + G+
Sbjct: 687 LVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVE--AQGS 744
Query: 1012 LIR----ARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC 1063
L++ AR R + + C Q C WE S C+ G G+ C
Sbjct: 745 LLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETC 800
Score = 96.7 bits (239), Expect = 1e-19
Identities = 57/174 (32%), Positives = 82/174 (47%), Gaps = 11/174 (6%)
Query: 927 CDATCGGGERKTTVSCTKIMSKNIS--IVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTE 984
C +CG G + + C + ++ I+ + +C+ L +PEPQ C+ +PC RW +
Sbjct: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQ-EACSLEPCPPRWKVMS 989
Query: 985 WTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQDCMTVWEAG 1043
PCS +CG G R VAC Q L G + E C +P ++ C DC W G
Sbjct: 990 LGPCSASCGLGTARRSVACVQ-LDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1048
Query: 1044 VWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWS 1097
W ECSV CG GI+ R C P+ + P A+ C+ K R G W+
Sbjct: 1049 TWMECSVSCGDGIQRRRDTCLGPQAQA-----PVPADFCQHLPKPVTVR-GCWA 1096
Score = 94.0 bits (232), Expect = 8e-19
Identities = 67/256 (26%), Positives = 97/256 (37%), Gaps = 21/256 (8%)
Query: 903 PLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISI-VDNEKCKYL 961
P P + +WT + C +CG G + C M + + V E C
Sbjct: 850 PSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLC---MDSALRVPVQEELCGLA 905
Query: 962 TKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLS--NGTLIRARERD 1019
+KP + C PC RW + CS +CG+G+ R + C + +G I +
Sbjct: 906 SKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILL-DTQ 963
Query: 1020 CIG-PKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTN---------PRKK 1069
C G P+P + C + C W+ CS CG G R+V C
Sbjct: 964 CQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAA 1023
Query: 1070 CVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCM--HKITGRHGNECF 1127
C RP + C Y W +G W +CS++CG G+Q R C+ + C
Sbjct: 1024 CAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQ 1083
Query: 1128 SSEKPAAYRPCHLQPC 1143
KP R C PC
Sbjct: 1084 HLPKPVTVRGCWAGPC 1099
Score = 84.7 bits (208), Expect = 5e-16
Identities = 59/276 (21%), Positives = 98/276 (35%), Gaps = 42/276 (15%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKY-LTKPEPQIRKCNEQPCQ 977
W + C A+CGGG R+ V C + + + +C+ +P + CN QPC
Sbjct: 715 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 774
Query: 978 TRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM 1037
RW ++E + C+ G G+ C + K + + C G C
Sbjct: 775 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCP 834
Query: 1038 TVW------------------------EAGVWS----ECSVKCGKGIRHRTVRCTNPRKK 1069
W A VW+ CSV CG+G+ C + +
Sbjct: 835 PGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALR 894
Query: 1070 -------CVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRH 1122
C L+++P + C + CS++CG+G+ R++ C
Sbjct: 895 VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDD 954
Query: 1123 GNE------CFSSEKPAAYRPCHLQPCNEKINVNTI 1152
G E C +P C L+PC + V ++
Sbjct: 955 GEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSL 990
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 256 bits (654), Expect = 9e-68
Identities = 161/499 (32%), Positives = 237/499 (47%), Gaps = 62/499 (12%)
Query: 626 TSRTSAPEH----LAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICE 681
+SRT+ E L W WS CSRTC G S R+C ++ C G +YR C
Sbjct: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRC----LSSKSCEGRNIRYRTCS 77
Query: 682 NPPCPAGLPGFRDWQCQAYSVRTSSPKH---ILQWQAVL-DEEKPCALFCSPVGKEQPIL 737
N CP FR QC A++ KH +W V D + PC+L C G +
Sbjct: 78 NVDCPPEAGDFRAQQCSAHN----DVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVE 133
Query: 738 LSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFN 797
L+ KV+DGT C + LD+C +G CQ VGCD LGS +ED+CGVCNG+G +C++++G +
Sbjct: 134 LAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYK 193
Query: 798 HTRGAGYVE--VLVIPAGARRIKVVEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAG 855
A + V+ IP G+R I++V + P H YL + Q + + +G F +
Sbjct: 194 SQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTL--QGTKGENSLSSTGTFLVDN 251
Query: 856 TTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEP 915
++V + + E + GP TA + + + + + + P
Sbjct: 252 SSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPI-------------- 297
Query: 916 LFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYL---TKPEPQIRKCN 972
+ W T + C ATCGGG + T+ C + S +V ++ C Y KP+P++++CN
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNR--VVADQYCHYYPENIKPKPKLQECN 355
Query: 973 EQPCQT-----------------RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRA 1015
PC RW T WT CS +CG G+QSR V+C ++ G +
Sbjct: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
Query: 1016 RERDCI-GPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKK----C 1070
E C+ PK AQ C DC W A WS C+V CG+G+R+R V C + R C
Sbjct: 416 EEWKCMYTPKMPIAQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
Query: 1071 VLSTRPREAEDCEDYSKCY 1089
T+P E+C + CY
Sbjct: 475 SPKTKPHIKEECIVPTPCY 493
Score = 89.0 bits (219), Expect = 3e-17
Identities = 61/204 (29%), Positives = 83/204 (40%), Gaps = 40/204 (19%)
Query: 974 QPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC------IGPKPAS 1027
QP RW T++ PCS TCG G Q C SN + ++ C I PKP
Sbjct: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA---DQYCHYYPENIKPKP-K 350
Query: 1028 AQRCEGQDC-----------------MTVWEAGVWSECSVKCGKGIRHRTVRCTNP---- 1066
Q C C + WEA W+ CS CG GI+ R V C
Sbjct: 351 LQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQG 410
Query: 1067 ------RKKCVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITG 1120
KC+ + + A+ C + C W +WS C++TCG+G++ RV+ C+ G
Sbjct: 411 HVTSVEEWKCMYTPKMPIAQPCNIFD-CPKWLAQEWSPCTVTCGQGLRYRVVLCIDH-RG 468
Query: 1121 RHGNECFSSEKPAAYRPCHL-QPC 1143
H C KP C + PC
Sbjct: 469 MHTGGCSPKTKPHIKEECIVPTPC 492
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 251 bits (640), Expect = 4e-66
Identities = 167/537 (31%), Positives = 248/537 (46%), Gaps = 69/537 (12%)
Query: 634 HLAGEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCPAGLPGFR 693
H + WSL++P S C+G +Q R C PCP P R
Sbjct: 347 HASSLWSLFAP-------------------SSPIPRCSGESEQLRACSQAPCPPEQPDPR 387
Query: 694 DWQCQAYSVRTSSPKHILQWQAVLDEE--KPCALFCSPVGKEQPILLSEKVMDGTSCGYQ 751
QC A++ + + + QW+ + + + C L C P G + +EKV DGT C
Sbjct: 388 ALQCAAFNSQEFMGQ-LYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLCQPG 446
Query: 752 GLDICANGRCQKVGCDGLLGSLAREDHCGVCNGNGKSCKIIKGDFNHTRGA-GYVEVLVI 810
DIC GRC GCDG+LGS R D CGVC G+ +C+++ G+ G GY ++L I
Sbjct: 447 APDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWI 506
Query: 811 PAGARRIKVVEEKPAHSYLALRDAGKQSI-NSDWKIEHSGAFNLAGTTVHYVR----RGL 865
PAGA R+++ + +P+ +YLALR G +SI N +W ++ G++ GT Y R G
Sbjct: 507 PAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGK 566
Query: 866 WEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDP-LPENQSSKAPEPLFMWTHTSW 924
E +SA+GPTT P+ + ++FQ++N G+ Y+Y I S P + EN + + P P
Sbjct: 567 GESLSAEGPTTQPVDVY-MIFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRV 625
Query: 925 EDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTE 984
E A R + + + I P P + W
Sbjct: 626 EPPLAPAPRPARTPGT-----LQRQVRIPQ--------MPAPPHPRTPLGSPAAYWKRVG 672
Query: 985 WTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPK--PASAQRCEGQDCMTVWEA 1042
+ CS +CGKG+ C + S L ER C PAS + C G C WEA
Sbjct: 673 HSACSASCGKGVWRPIFLCISRESGEEL---DERSCAAGARPPASPEPCHGTPCPPYWEA 729
Query: 1043 GVWSECSVKCGKGIRHRTVRCTN---------PRKKCVLSTRPREAEDCEDYSKCYVWRM 1093
G W+ CS CG G +HR ++C P ++C RP + C+ C W +
Sbjct: 730 GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQ-LRLCGHWEV 788
Query: 1094 GD-WSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSE------KPAAYRPCHLQPC 1143
G WS+CS+ CG+G +SR ++C+ G +G+E E +P + C + PC
Sbjct: 789 GSPWSQCSVRCGRGQRSRQVRCV----GNNGDEVSEQECASGPPQPPSREACDMGPC 841
Score = 36.2 bits (82), Expect = 0.19
Identities = 13/35 (37%), Positives = 17/35 (48%)
Query: 626 TSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC 660
T PE + G W W+ CS+ C G+ R R C
Sbjct: 37 TEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTC 71
Score = 31.2 bits (69), Expect = 6.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 1032 EGQDCMTVWEAGV-WSECSVKCGKGIRHRTVRCTNP 1066
EGQ VW V W+ CS CG G++ R+ C P
Sbjct: 39 EGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 217 bits (552), Expect = 6e-56
Identities = 149/514 (28%), Positives = 223/514 (43%), Gaps = 41/514 (7%)
Query: 665 SEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQ--AVLDEEKP 722
S A C G +QY++C CP R+ QC +Y+ + + +W+ A + +
Sbjct: 286 STAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGR-FYEWEPFAEVKGNRK 344
Query: 723 CALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVC 782
C L C +G + +EKV+DGT C G IC +G+C+ +GCD LGS D CGVC
Sbjct: 345 CELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVC 404
Query: 783 NGNGKSCKIIKGDFNHT-RGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRD-AGKQSIN 840
G+ C+++ G F H GY V+ IP GA +I + E +++YLALR +G+ IN
Sbjct: 405 GGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIIN 464
Query: 841 SDWKIEHSGAFNLAGTTVHYVRRG-----LWEKISAKGPTTAPLHLLVLLFQDQNYGLHY 895
+W I+ G + GT Y R E A+GPT L + ++ Q N G+HY
Sbjct: 465 GNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILD-VYMIHQQPNPGVHY 523
Query: 896 EYTIP-----SDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERK-----------TT 939
EY I S +P ++ P M T ++ G E K T+
Sbjct: 524 EYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTS 583
Query: 940 VSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSR 999
S ++ + L P PQ + + W T CS TCGKG Q
Sbjct: 584 ESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSR---DHNWKQLGTTECSTTCGKGSQYP 640
Query: 1000 QVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHR 1059
C + ++ + + P P + C C W+ G WSECS CG G++HR
Sbjct: 641 IFRCVHRSTHEEAPESYCDSSMKPTP-EEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHR 699
Query: 1060 TVRCTNPRKKCVLSTRPREAEDCE--------DYSKCYVWRM-GDWSKCSITCGKGMQSR 1110
V C L+ +P + E C W++ DW+ CS+ CG G ++R
Sbjct: 700 QVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTR 759
Query: 1111 VIQCMHKITG-RHGNECFSSEKPAAYRPCHLQPC 1143
++C+ I EC +P C + PC
Sbjct: 760 DVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC 793
Score = 137 bits (345), Expect = 6e-32
Identities = 88/259 (33%), Positives = 122/259 (47%), Gaps = 22/259 (8%)
Query: 903 PLPENQSSKA-PEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYL 961
P PE + P P F W W +C TCG G + V C ++ + V +C++L
Sbjct: 664 PTPEEEPCNIFPCPAF-WDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHL 722
Query: 962 TKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCI 1021
KPE C + C + T+WT CS CG G ++R V C + G ++ E + +
Sbjct: 723 EKPETT-STCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNI--GDVVDDEECN-M 778
Query: 1022 GPKPASAQRCEGQDCMTVWEAGVWSE-CSVKCGKGIRHRTVRC-TN-----PRKKCVLST 1074
+P + C+ C W WSE CS +CG G+R R+V C TN P + C +
Sbjct: 779 KLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NN 837
Query: 1075 RPREAEDCEDYSKC---YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGR----HGNECF 1127
RP EA C D C W G WS+CSI CG G Q R + C+ K +EC
Sbjct: 838 RPAEATPC-DNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECS 896
Query: 1128 SSEKPAAYRPCHLQPCNEK 1146
EKP + + CHL+PC K
Sbjct: 897 FLEKPPSQQSCHLKPCGAK 915
Score = 132 bits (333), Expect = 2e-30
Identities = 79/256 (30%), Positives = 114/256 (44%), Gaps = 16/256 (6%)
Query: 905 PENQSSKAPEPL-----FMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCK 959
P+N AP+P W +C TCG G + C + C
Sbjct: 602 PDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRC--VHRSTHEEAPESYCD 659
Query: 960 YLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERD 1019
KP P+ CN PC W + EW+ CS+TCG GMQ RQV C Q +N +L R
Sbjct: 660 SSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRC 719
Query: 1020 CIGPKPASAQRCEGQDCMTVWEAGV-WSECSVKCGKGIRHRTVRCTN------PRKKCVL 1072
KP + C+ + C + W+ W+ CSV CG G R R V+C + ++C +
Sbjct: 720 QHLEKPETTSTCQLKIC-SEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNM 778
Query: 1073 STRPREAEDCEDYSKCYVWRMGDWS-KCSITCGKGMQSRVIQCMHKITGRHGNECFSSEK 1131
RP + E+C+ W + +WS +CS CG G+++R + CM E + +
Sbjct: 779 KLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNR 838
Query: 1132 PAAYRPCHLQPCNEKI 1147
PA PC PC K+
Sbjct: 839 PAEATPCDNGPCTGKV 854
Score = 125 bits (314), Expect = 2e-28
Identities = 80/287 (27%), Positives = 118/287 (41%), Gaps = 38/287 (13%)
Query: 922 TSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWM 981
T W C CG G+R V C + +VD+E+C +P I C+ PC W
Sbjct: 743 TDWTSCSVPCGVGQRTRDVKCVSNIG---DVVDDEECNMKLRPN-DIENCDMGPCAKSWF 798
Query: 982 MTEWTP-CSRTCGKGMQSRQVAC-TQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM-- 1037
+TEW+ CS CG G+++R V C T +S+ L C +PA A C+ C
Sbjct: 799 LTEWSERCSAECGAGVRTRSVVCMTNHVSSLPL-----EGCGNNRPAEATPCDNGPCTGK 853
Query: 1038 TVWEAGVWSECSVKCGKGIRHRTVRCTNPR---------KKCVLSTRPREAEDCEDYSKC 1088
W AG WS+CS++CG G + R V C +C +P + C
Sbjct: 854 VEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCG 913
Query: 1089 YVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNEKIN 1148
W +WS CS +C G + R ++C+ N C KP C+ Q C +++
Sbjct: 914 AKWFSTEWSMCSKSCQGGFRVREVRCLSD-DMTLSNLCDPQLKPEERESCNPQDCVPEVD 972
Query: 1149 VNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETC 1195
N C + C V+ + LC + CC +C
Sbjct: 973 EN-------------CKDKYY--NCNVVVQARLCVYNYYKTACCASC 1004
Score = 86.7 bits (213), Expect = 1e-16
Identities = 53/171 (30%), Positives = 72/171 (42%), Gaps = 12/171 (7%)
Query: 919 WTHTSW-EDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPC- 976
W T W E C A CG G R +V C M+ ++S + E C + C+ PC
Sbjct: 797 WFLTEWSERCSAECGAGVRTRSVVC---MTNHVSSLPLEGCG--NNRPAEATPCDNGPCT 851
Query: 977 -QTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQD 1035
+ W W+ CS CG G Q R+V C ++ ++ + KP S Q C +
Sbjct: 852 GKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKP 911
Query: 1036 CMTVWEAGVWSECSVKCGKGIRHRTVRCTNP----RKKCVLSTRPREAEDC 1082
C W + WS CS C G R R VRC + C +P E E C
Sbjct: 912 CGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESC 962
Score = 79.3 bits (194), Expect = 2e-14
Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 6/119 (5%)
Query: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
W SW C CG G ++ V C + + ++D +C +L KP P + C+ +PC
Sbjct: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKP-PSQQSCHLKPCGA 914
Query: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM 1037
+W TEW+ CS++C G + R+V C + TL + KP + C QDC+
Sbjct: 915 KWFSTEWSMCSKSCQGGFRVREVRCLS--DDMTLSNLCDPQL---KPEERESCNPQDCV 968
Score = 36.6 bits (83), Expect = 0.15
Identities = 28/73 (38%), Positives = 31/73 (42%), Gaps = 14/73 (19%)
Query: 637 GEWSLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQ 696
G W WS CSR+CS G+ + R C L R G R P PA F D
Sbjct: 57 GAWGPWSACSRSCSGGVMEQTRPC--LPRSYRLRGGQR--------PGAPA--RAFADHV 104
Query: 697 CQAYSVRTSSPKH 709
A VRTS P H
Sbjct: 105 VSA--VRTSVPLH 115
Score = 35.8 bits (81), Expect = 0.25
Identities = 34/117 (29%), Positives = 45/117 (38%), Gaps = 20/117 (17%)
Query: 581 QEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWS 640
Q + V C V ++EC KL P D +CD+G K+ T EWS
Sbjct: 756 QRTRDVKCVSNIGDVVDDEECNMKLRPN-DIENCDMGPCAKSWFLT-----------EWS 803
Query: 641 LWSPCSRTCSAGISSRERKC-----PGLDSEARDCNGPRKQYRICENPPCPAGLPGF 692
CS C AG+ +R C L E N P + C+N PC + F
Sbjct: 804 --ERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRP-AEATPCDNGPCTGKVEWF 857
Score = 33.9 bits (76), Expect = 0.96
Identities = 22/72 (30%), Positives = 30/72 (41%), Gaps = 6/72 (8%)
Query: 905 PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKP 964
P QS W T W C +C GG R V C +S ++++ + C KP
Sbjct: 902 PSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRC---LSDDMTL--SNLCDPQLKP 956
Query: 965 EPQIRKCNEQPC 976
E + CN Q C
Sbjct: 957 EER-ESCNPQDC 967
Score = 31.2 bits (69), Expect = 6.2
Identities = 23/77 (29%), Positives = 31/77 (40%), Gaps = 13/77 (16%)
Query: 608 PMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKCPGLDSEA 667
P + T CD G CT + E AG WS CS C +G RE C +++
Sbjct: 839 PAEATPCD------NGPCTGKV---EWFAGSWS---QCSIECGSGTQQREVICVRKNADT 886
Query: 668 RDCNGPRKQYRICENPP 684
+ P + E PP
Sbjct: 887 FEVLDP-SECSFLEKPP 902
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 185 bits (469), Expect = 3e-46
Identities = 149/491 (30%), Positives = 234/491 (47%), Gaps = 54/491 (10%)
Query: 146 PQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTG 205
P PS P EP G + + F RDL+L LR + R +AP +E + G
Sbjct: 91 PVRTPSFPGGNEEEP-GSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRV- 148
Query: 206 AASAPQPPAPPDAGCFYTGAV--LRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTM 263
P C Y G V L S+A S C G L G I++ E+ FIEPL +
Sbjct: 149 --------EPLLGSCLYVGDVAGLAEASSVA-LSNCDG-LAGLIRMEEEEFFIEPLEKGL 198
Query: 264 AIT----GHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKI------AESGR 313
A G H VYR+ + + AL + G D SR + A S R
Sbjct: 199 AAQEAEQGRVHVVYRRPPT-SPPLGGPQALDT---GASLDSLDSLSRALGVLEEHANSSR 254
Query: 314 GKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLR 373
+ + +YNIE ++ D ++V +HG + ++++LT++N+V ++ +SL +N+
Sbjct: 255 RRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVV 314
Query: 374 VIKLILLH--ETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDA 431
++++ILL ++ + IG+ + LE+ C+W +L+ + G D D
Sbjct: 315 LVRIILLSYGKSMSLIEIGNPSQS-LENVCRW----------AYLQQKPDTGHDEYH-DH 362
Query: 432 AILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGIN 491
AI +TR+DF P G A ++GMC R C + ++G + AF +AHE GH +G+
Sbjct: 363 AIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGME 417
Query: 492 HDNDHPSCADGLHIMS-GEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVN 550
HD C D + + S + WSRCS+++L R+L S +CLL +P + +
Sbjct: 418 HDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLD-DPFAHD 474
Query: 551 SVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHV-ICTGLWCK-VEGEKECRTKLDPP 608
+P +LPG+ Y+ +EQC+ FG C + C LWC + C+TK PP
Sbjct: 475 WPALP-QLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPP 533
Query: 609 MDGTDCDLGKW 619
+DGT C GK+
Sbjct: 534 LDGTMCAPGKF 544
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,614,241
Number of Sequences: 37866
Number of extensions: 3491167
Number of successful extensions: 45373
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 501
Number of HSP's successfully gapped in prelim test: 1041
Number of HSP's that attempted gapping in prelim test: 24484
Number of HSP's gapped (non-prelim): 11540
length of query: 1207
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1093
effective length of database: 13,930,794
effective search space: 15226357842
effective search space used: 15226357842
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.