Guide to the Human Genome
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Search of human proteins with 17738292

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor
[Homo sapiens]
         (343 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...   691   0.0  
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...   691   0.0  
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H...   691   0.0  
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]   193   2e-49
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...   189   4e-48
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo...   188   5e-48
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom...   188   5e-48
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom...   188   5e-48
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo...   188   5e-48
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                  182   5e-46
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...   170   1e-42
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]    168   6e-42
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi...   162   3e-40
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          93   4e-19
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    91   1e-18
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    87   2e-17
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    82   9e-16
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom...    74   1e-13
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]    70   4e-12
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    69   5e-12
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    67   2e-11
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    67   3e-11
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           59   5e-09
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo...    59   6e-09
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...    58   1e-08
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho...    57   3e-08
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho...    57   3e-08
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      56   4e-08
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       56   4e-08
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           55   9e-08

>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score =  691 bits (1783), Expect = 0.0
 Identities = 343/343 (100%), Positives = 343/343 (100%)

Query: 1   MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60
           MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV
Sbjct: 1   MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60

Query: 61  TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120
           TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV
Sbjct: 61  TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120

Query: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180
           EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL
Sbjct: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180

Query: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240
           PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN
Sbjct: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240

Query: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300
           FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID
Sbjct: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300

Query: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343
           AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR
Sbjct: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343


>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score =  691 bits (1783), Expect = 0.0
 Identities = 343/343 (100%), Positives = 343/343 (100%)

Query: 1   MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60
           MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV
Sbjct: 1   MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60

Query: 61  TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120
           TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV
Sbjct: 61  TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120

Query: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180
           EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL
Sbjct: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180

Query: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240
           PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN
Sbjct: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240

Query: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300
           FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID
Sbjct: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300

Query: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343
           AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR
Sbjct: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343


>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
           sapiens]
          Length = 343

 Score =  691 bits (1783), Expect = 0.0
 Identities = 343/343 (100%), Positives = 343/343 (100%)

Query: 1   MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60
           MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV
Sbjct: 1   MLATRLSRPLSRLPGKTLSACDRENGARRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLV 60

Query: 61  TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120
           TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV
Sbjct: 61  TGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEV 120

Query: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180
           EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL
Sbjct: 121 EKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFL 180

Query: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240
           PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN
Sbjct: 181 PLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGN 240

Query: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300
           FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID
Sbjct: 241 FIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVID 300

Query: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343
           AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR
Sbjct: 301 AVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISDMIYIR 343


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score =  193 bits (491), Expect = 2e-49
 Identities = 117/291 (40%), Positives = 173/291 (59%), Gaps = 15/291 (5%)

Query: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
           K V +TGCDSGFG  LA+ L ++G  V A CL +     G ++L    SDRL TV L+V 
Sbjct: 30  KYVFITGCDSGFGNLLARQLDARGLRVLAACLTEK----GAEQLRGQTSDRLETVTLDVT 85

Query: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWGTVR 174
             E +    + V+  + D  +G+WGLVNNAGI T     E+ + E    + +VNL G ++
Sbjct: 86  KMESIAAATQWVKEHVGD--RGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQ 143

Query: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
           +T S LPL+RRA+GR+VN+SS+LGR+A      YC++K+GVEAFSD LR E+   GVK+S
Sbjct: 144 VTLSMLPLVRRARGRIVNVSSILGRVAFFV-GGYCVSKYGVEAFSDILRREIQHFGVKIS 202

Query: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTD 294
           +VEPG F   T + +        K+ W+E P+ +++ YG++YFD     M+    + ST+
Sbjct: 203 IVEPGYF--RTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTN 260

Query: 295 TSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQI--MTHLPGAISDMIYIR 343
            + V D + HALT+  P TRY      W  +     +++LP +++D I  R
Sbjct: 261 LNLVTDCMEHALTSVHPRTRY---SAGWDAKFFFIPLSYLPTSLADYILTR 308


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score =  189 bits (479), Expect = 4e-48
 Identities = 105/266 (39%), Positives = 159/266 (59%), Gaps = 10/266 (3%)

Query: 53  VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQL 112
           +  K V +TGCDSGFG  LAK L  +G  V A C  ++    G ++L    S RL+T  L
Sbjct: 23  LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEE----GSQKLQRDTSYRLQTTLL 78

Query: 113 NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWG 171
           +V  SE ++   + VR   K  E+G+W LVNNAG+    G  E+ + + + +V  VNL G
Sbjct: 79  DVTKSESIKAAAQWVRD--KVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVG 136

Query: 172 TVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGV 231
            + +T   LP+++RA+GRVVN+SS  GR+A      YC++KFGVEAFSD +R E+Y  GV
Sbjct: 137 LIEVTLHMLPMVKRARGRVVNMSSSGGRVA-VIGGGYCVSKFGVEAFSDSIRRELYYFGV 195

Query: 232 KVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSG 291
           KV ++EPGN+   T++   E++++  +K+WE LP+  R  YG+ YF     K++      
Sbjct: 196 KVCIIEPGNY--RTAILGKENLESRMRKLWERLPQETRDSYGEDYFRIYTDKLKNIMQVA 253

Query: 292 STDTSPVIDAVTHALTATTPYTRYHP 317
                 VI+++ HA+ + +P  RY+P
Sbjct: 254 EPRVRDVINSMEHAIVSRSPRIRYNP 279


>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  188 bits (478), Expect = 5e-48
 Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)

Query: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
           E +  K + +TGCDSGFG   A+    KGF V A CL +     G   L +  S+RLRTV
Sbjct: 25  EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80

Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
            L+V   E V++  + V++ +   EKG+WGL+NNAG+       ++ +LE Y++  EVNL
Sbjct: 81  LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138

Query: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
           +G + +T + LPL+++A+GRV+N+SS+ GR+A      Y  +K+ VE F+D LR +M   
Sbjct: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197

Query: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
           GV VS +EPG F   T+L  P  ++ I KK+  WE+L   +++ YG+ Y ++ + K++  
Sbjct: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253

Query: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
            S  + D SPV++ + HALT+  P T Y        +W+    ++H+P A+ D + ++
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308


>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  188 bits (478), Expect = 5e-48
 Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)

Query: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
           E +  K + +TGCDSGFG   A+    KGF V A CL +     G   L +  S+RLRTV
Sbjct: 25  EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80

Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
            L+V   E V++  + V++ +   EKG+WGL+NNAG+       ++ +LE Y++  EVNL
Sbjct: 81  LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138

Query: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
           +G + +T + LPL+++A+GRV+N+SS+ GR+A      Y  +K+ VE F+D LR +M   
Sbjct: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197

Query: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
           GV VS +EPG F   T+L  P  ++ I KK+  WE+L   +++ YG+ Y ++ + K++  
Sbjct: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253

Query: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
            S  + D SPV++ + HALT+  P T Y        +W+    ++H+P A+ D + ++
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308


>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  188 bits (478), Expect = 5e-48
 Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)

Query: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
           E +  K + +TGCDSGFG   A+    KGF V A CL +     G   L +  S+RLRTV
Sbjct: 25  EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80

Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
            L+V   E V++  + V++ +   EKG+WGL+NNAG+       ++ +LE Y++  EVNL
Sbjct: 81  LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138

Query: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
           +G + +T + LPL+++A+GRV+N+SS+ GR+A      Y  +K+ VE F+D LR +M   
Sbjct: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197

Query: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
           GV VS +EPG F   T+L  P  ++ I KK+  WE+L   +++ YG+ Y ++ + K++  
Sbjct: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253

Query: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
            S  + D SPV++ + HALT+  P T Y        +W+    ++H+P A+ D + ++
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308


>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score =  188 bits (478), Expect = 5e-48
 Identities = 110/298 (36%), Positives = 177/298 (59%), Gaps = 19/298 (6%)

Query: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
           E +  K + +TGCDSGFG   A+    KGF V A CL +     G   L +  S+RLRTV
Sbjct: 25  EDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTES----GSTALKAETSERLRTV 80

Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI-STFGEVEFTSLETYKQVAEVNL 169
            L+V   E V++  + V++ +   EKG+WGL+NNAG+       ++ +LE Y++  EVNL
Sbjct: 81  LLDVTDPENVKRTAQWVKNQVG--EKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNL 138

Query: 170 WGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
           +G + +T + LPL+++A+GRV+N+SS+ GR+A      Y  +K+ VE F+D LR +M   
Sbjct: 139 FGLISVTLNMLPLVKKAQGRVINVSSVGGRLA-IVGGGYTPSKYAVEGFNDSLRRDMKAF 197

Query: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKM--WEELPEVVRKDYGKKYFDEKIAKMETY 287
           GV VS +EPG F   T+L  P  ++ I KK+  WE+L   +++ YG+ Y ++ + K++  
Sbjct: 198 GVHVSCIEPGLF--KTNLADP--VKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGN 253

Query: 288 CSSGSTDTSPVIDAVTHALTATTPYTRYHPMD--YYWWLRMQIMTHLPGAISDMIYIR 343
            S  + D SPV++ + HALT+  P T Y        +W+    ++H+P A+ D + ++
Sbjct: 254 KSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIP---LSHMPAALQDFLLLK 308


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score =  182 bits (461), Expect = 5e-46
 Identities = 110/264 (41%), Positives = 159/264 (60%), Gaps = 16/264 (6%)

Query: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
           K V +TGCDSGFG  LA+ L ++G  V A CL +     G ++L    SDRL TV L+V 
Sbjct: 30  KYVFITGCDSGFGKLLARQLDARGLRVLAACLTEK----GAEQLRGQTSDRLETVTLDVT 85

Query: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIST-FGEVEFTSLETYKQVAEVNLWGTVR 174
            +E V    + V+  ++D  KG+WGLVNNAGIS      E  + + +  + +VNL G + 
Sbjct: 86  KTESVAAAAQWVKECVRD--KGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVID 143

Query: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
           +T S LPL+RRA+GRVVN+SS++GR+ +     YCI+K+GVEAFSD LR E+   GVKV+
Sbjct: 144 VTLSLLPLVRRARGRVVNVSSVMGRV-SLFGGGYCISKYGVEAFSDSLRRELSYFGVKVA 202

Query: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKY---FDEKIAKMETYCSSG 291
           ++EPG F   T++ S E       ++W+     V++ YG+K+   + +   +ME  C+  
Sbjct: 203 MIEPGYF--KTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQ- 259

Query: 292 STDTSPVIDAVTHALTATTPYTRY 315
             D S V + + HAL A  P TRY
Sbjct: 260 --DLSLVTNCMEHALIACHPRTRY 281


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score =  170 bits (431), Expect = 1e-42
 Identities = 102/271 (37%), Positives = 153/271 (56%), Gaps = 17/271 (6%)

Query: 52  PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ 111
           P  +  V +TGCDSGFG  LA  L  +GF V A CL       G ++L  + S RL T  
Sbjct: 25  PASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPS----GAEDLQRVASSRLHTTL 80

Query: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLW 170
           L++   + V++  + V   +K  E G++GLVNNAG++   G   + + + +++V  VN  
Sbjct: 81  LDITDPQSVQQAAKWVEMHVK--EAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTM 138

Query: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
           G + +T + LPL+++A+GRV+NI+S+LGR+A      YC++KFG+EAFSD LR ++   G
Sbjct: 139 GPIGVTLALLPLLQQARGRVINITSVLGRLAANGGG-YCVSKFGLEAFSDSLRRDVAHFG 197

Query: 231 VKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYG----KKYFDEKIAKMET 286
           ++VS+VEPG F   T + + ES++   +  W  LP   +  YG     KY   +   M  
Sbjct: 198 IRVSIVEPGFF--RTPVTNLESLEKTLQACWARLPPATQAHYGGAFLTKYLKMQQRIMNL 255

Query: 287 YCSSGSTDTSPVIDAVTHALTATTPYTRYHP 317
            C    T  S  ++   HALTA  P TRY P
Sbjct: 256 ICDPDLTKVSRCLE---HALTARHPRTRYSP 283


>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
          Length = 387

 Score =  168 bits (426), Expect = 6e-42
 Identities = 107/287 (37%), Positives = 160/287 (55%), Gaps = 15/287 (5%)

Query: 45  TYASAAE--PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSL 102
           TY S  E  PV  KAVLVTG D G G +L K+L   GF VFAG L  ++   G +EL   
Sbjct: 70  TYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVL--NENGPGAEELRRT 127

Query: 103 NSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFG-EVEFTSLETY 161
            S RL  +Q+++    +++     V + L+D  +G+W ++NNAG+  F  + E   +  Y
Sbjct: 128 CSPRLSVLQMDITKPVQIKDAYSKVAAMLQD--RGLWAVINNAGVLGFPTDGELLLMTDY 185

Query: 162 KQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDC 221
           KQ   VN +GTV +TK+FLPL+R++KGR+VN+SSM G       + Y  +K  V  FS  
Sbjct: 186 KQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSV 245

Query: 222 LRYEMYPLGVKVSVVEPGNF---IAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFD 278
           +R E+   G+KV+ ++PG F   IA TS    +  + + K + + LP  V++DYG+ Y  
Sbjct: 246 MRLELSKWGIKVASIQPGGFLTNIAGTS----DKWEKLEKDILDHLPAEVQEDYGQDYIL 301

Query: 279 EKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHP-MDYYWWL 324
            +   +    S  S D SPV+  + HA+ A +P+  Y P    Y W+
Sbjct: 302 AQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWI 348


>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
           sapiens]
          Length = 405

 Score =  162 bits (411), Expect = 3e-40
 Identities = 97/275 (35%), Positives = 147/275 (53%), Gaps = 22/275 (8%)

Query: 52  PVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQ 111
           PV ++AVL+TGCDSGFG   AK L S GF V A  L  +    G  EL +  S RLR +Q
Sbjct: 79  PVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVL--ELNSPGAIELRTCCSPRLRLLQ 136

Query: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGIS-TFGEVEFTSLETYKQVAEVNLW 170
           +++    ++ +V+E  ++       G+WGLVNNAG +    + E + + T++   EVN +
Sbjct: 137 MDLTKPGDISRVLEFTKAHTTST--GLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFF 194

Query: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
           G + +TK  LPL+R ++GR+V + S  G M  P    Y  +K  V    D    E+ P G
Sbjct: 195 GALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWG 254

Query: 231 VKVSVVEPGNFIAATSLYSPESIQAIAKKMWEE--------LPEVVRKDYGKKYFDEKIA 282
           VKVS+++PG F         ES++ + +  WE+        LP+ + + YGK Y +    
Sbjct: 255 VKVSIIQPGCF-------KTESVRNVGQ--WEKRKQLLLANLPQELLQAYGKDYIEHLHG 305

Query: 283 KMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHP 317
           +         +D +PV+DA+T AL A  P  RY+P
Sbjct: 306 QFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYP 340


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 92.8 bits (229), Expect = 4e-19
 Identities = 77/267 (28%), Positives = 123/267 (46%), Gaps = 26/267 (9%)

Query: 56  KAVLVTGCDSGFGFSLA---KHLHSKGFLVFAGCLMKDKGHDGVKELDSLNS--DRLRTV 110
           + VL++GC SG G  LA    H   K + V A   M+D G     E  +  +    L   
Sbjct: 6   RTVLISGCSSGIGLELAVQLAHDPKKRYQVVA--TMRDLGKKETLEAAAGEALGQTLTVA 63

Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLW 170
           QL+VCS E V + +  ++  +         LVNNAG+   G +E  SL   + V + N +
Sbjct: 64  QLDVCSDESVAQCLSCIQGEVDV-------LVNNAGMGLVGPLEGLSLAAMQNVFDTNFF 116

Query: 171 GTVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL 229
           G VR+ K+ LP + RR +G +V ISS++G         Y  +KF +E F + L  ++   
Sbjct: 117 GAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQF 176

Query: 230 GVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKI--AKMETY 287
            + +S+VEPG  +  T        Q    +     PE +       YF +    A  + +
Sbjct: 177 NIFISLVEPGPVV--TEFEGKLLAQVSMAEFPGTDPETLH------YFRDLYLPASRKLF 228

Query: 288 CSSGSTDTSPVIDAVTHALTATTPYTR 314
           CS G  +   V+ A+ + +++T P  R
Sbjct: 229 CSVGQ-NPQDVVQAIVNVISSTRPPLR 254


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 62/187 (33%), Positives = 107/187 (57%), Gaps = 8/187 (4%)

Query: 58  VLVTGCDSGFGFSLAKHLHSKGF-LVFAGCLMKDKG--HDGVKELDSLNSDRLRTVQLNV 114
           V++TG  SG G   AK  ++ G  LV  G   ++ G   + ++EL + ++ +++T +  +
Sbjct: 55  VVITGATSGLGKECAKVFYAAGAKLVLCG---RNGGALEELIRELTASHATKVQTHKPYL 111

Query: 115 CSSEEVEK-VVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTV 173
            + +  +   +    + +      +  LVNNAGIS  G +  T+++  K+V E N +G V
Sbjct: 112 VTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPV 171

Query: 174 RMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVK 232
            +TK+ LP +I+R +G +V ISS+ G+M+ P RS Y  +K   +AF DCLR EM    ++
Sbjct: 172 ALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIE 231

Query: 233 VSVVEPG 239
           V+V+ PG
Sbjct: 232 VTVISPG 238


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 72/206 (34%), Positives = 101/206 (49%), Gaps = 17/206 (8%)

Query: 58  VLVTGCDSGFGFSLAKHLHS---KGFLVFAGCL-MKDKGH--DGVKELDSLNSDRLRTVQ 111
           VL+TGC SG G  LA  L S   + F V+A    +K +G   +  + L +     L T+Q
Sbjct: 6   VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARAL-ACPPGSLETLQ 64

Query: 112 LNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWG 171
           L+V  S+ V    E V     D       LV NAG+   G +E    +    V +VN+ G
Sbjct: 65  LDVRDSKSVAAARERVTEGRVDV------LVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118

Query: 172 TVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
           TVRM ++FLP + RR  GRV+   S+ G M  P    YC +KF +E   + L   + P G
Sbjct: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178

Query: 231 VKVSVVEPGNFIAA---TSLYSPESI 253
           V +S++E G    A     L SPE +
Sbjct: 179 VHLSLIECGPVHTAFMEKVLGSPEEV 204


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 81.6 bits (200), Expect = 9e-16
 Identities = 62/210 (29%), Positives = 104/210 (49%), Gaps = 25/210 (11%)

Query: 56  KAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVC 115
           K V+VTG   G G  + +   + G    A  ++ DK   G + L+      L      +C
Sbjct: 10  KVVVVTGGGRGIGAGIVRAFVNSG----ARVVICDKDESGGRALEQ----ELPGAVFILC 61

Query: 116 SSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGE-VEFTSLETYKQVAEVNLWGTVR 174
              + + V  +V  +++   + +  +VNNAG     +  E TS + ++Q+ E+NL GT  
Sbjct: 62  DVTQEDDVKTLVSETIRRFGR-LDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYT 120

Query: 175 MTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVS 234
           +TK  LP +R+++G V+NISS++G +      PY  TK  V A +  L  +  P GV+V+
Sbjct: 121 LTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180

Query: 235 VVEPGNFIAATSLYSPESIQAIAKKMWEEL 264
            + PGN      +++P         +WEEL
Sbjct: 181 CISPGN------IWTP---------LWEEL 195


>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
           sapiens]
          Length = 311

 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 17/227 (7%)

Query: 31  LLLGSTSFIPIGR---RTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCL 87
           LLLG +  + I +   R ++ +A  V +K V++T   SG G   A+  H+ G    A  +
Sbjct: 12  LLLGISGLLFIYQEVSRLWSKSA--VQNKVVVITDAISGLGKECARVFHTGG----ARLV 65

Query: 88  MKDKGHDGVKEL-DSLNS----DRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLV 142
           +  K  + ++ L D+L S     +  T +L +    ++  V ++ +  L D    +  L+
Sbjct: 66  LCGKNWERLENLYDALISVADPSKTFTPKLVLLDLSDISCVPDVAKEVL-DCYGCVDILI 124

Query: 143 NNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMA 201
           NNA +   G     SLE  K++ + N +G + +TK+ LP +I R  G++V ++++ G+  
Sbjct: 125 NNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNNIQGKFG 184

Query: 202 NPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLY 248
            P R+ Y  +K     F DCLR E+    V +S V P  FI +  +Y
Sbjct: 185 IPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSP-TFIRSYHVY 230


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 60/194 (30%), Positives = 89/194 (45%), Gaps = 13/194 (6%)

Query: 59  LVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSE 118
           +VTG   G G S A+ L   G  V      KDK      E+        RT+ ++  S +
Sbjct: 54  VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASED 113

Query: 119 EVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSL----ETYKQVAEVNLWGTVR 174
             +K+    ++ L   E G+  LVNN G+S      F  +       K++  +N+    +
Sbjct: 114 IYDKI----KTGLAGLEIGI--LVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167

Query: 175 MTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKV 233
           MT+  LP ++ R+KG ++NISS  G +  P  + Y  TK  V+ FS CL  E    GV V
Sbjct: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFV 227

Query: 234 SVVEPGNFIAATSL 247
             V P  +  AT L
Sbjct: 228 QSVLP--YFVATKL 239


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 61/190 (32%), Positives = 95/190 (50%), Gaps = 15/190 (7%)

Query: 58  VLVTGCDSGFGFSLAKHLHSKGF-LVFAGCLMKDKGHDGVK----ELDSLNSDRLRTVQL 112
           V VTG  SG G  LA  L   G  LV +   + +   + VK    E  +L    +  + L
Sbjct: 53  VWVTGASSGIGEELAYQLSKLGVSLVLSARRVHEL--ERVKRRCLENGNLKEKDILVLPL 110

Query: 113 NVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGT 172
           ++  +   E   + V       +     LVNN G+S       TSL+ Y+++ E+N  GT
Sbjct: 111 DLTDTGSHEAATKAVLQEFGRIDI----LVNNGGMSQRSLCMDTSLDVYRKLIELNYLGT 166

Query: 173 VRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEM--YPL 229
           V +TK  LP +I R +G++V ++S+LG ++ P    YC +K  +  F + LR E+  YP 
Sbjct: 167 VSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYP- 225

Query: 230 GVKVSVVEPG 239
           G+ VS + PG
Sbjct: 226 GIIVSNICPG 235


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 49/191 (25%), Positives = 93/191 (48%), Gaps = 7/191 (3%)

Query: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
           +P+ +K  LVT    G GF++A+ L   G    A  ++  +    V +  +       +V
Sbjct: 28  DPLANKVALVTASTDGIGFAIARRLAQDG----AHVVVSSRKQQNVDQAVATLQGEGLSV 83

Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTF-GEVEFTSLETYKQVAEVNL 169
              VC   + E    +V +++K    G+  LV+NA ++ F G +   + E + +  ++N+
Sbjct: 84  TGTVCHVGKAEDRERLVATAVK-LHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINV 142

Query: 170 WGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYP 228
                MTK+ +P + +R  G VV +SS+     +P  SPY ++K  +   +  L  E+ P
Sbjct: 143 KAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAP 202

Query: 229 LGVKVSVVEPG 239
             ++V+ + PG
Sbjct: 203 RNIRVNCLAPG 213


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 46/185 (24%), Positives = 94/185 (50%), Gaps = 7/185 (3%)

Query: 58  VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117
           V+VTG  SG G  +A   + +G  +      +DK     KE++  +   +   Q+ +C S
Sbjct: 35  VVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHS---INDKQVVLCIS 91

Query: 118 EEVEKVVEIVRSSLKDPEKGMWG---LVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVR 174
            +V +    V + +K  ++ +     LVN AG++  G+ E   + T++++  +N  G+V 
Sbjct: 92  VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVY 151

Query: 175 MTKSFLPLIR-RAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKV 233
            +++ +  ++ R  GR+V +SS  G++     + Y  +KF +   ++ L+ E+ P  V +
Sbjct: 152 PSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYI 211

Query: 234 SVVEP 238
           +V  P
Sbjct: 212 TVAYP 216


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 57/225 (25%), Positives = 96/225 (42%), Gaps = 13/225 (5%)

Query: 31  LLLGSTSFIPIGRRTYASAAEP---VGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCL 87
           + LG + F  +    +A   +P   V  + VL+TG  SG G  LA      G ++    +
Sbjct: 13  IFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDI 72

Query: 88  MKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGI 147
            K+   +  K      + R+     +    E V +V + V+  + D       L+NNAGI
Sbjct: 73  NKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSI----LINNAGI 128

Query: 148 STFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARS 206
            T  +      E  ++  +VN    +   K+FLP +I    G +V ISS  G       +
Sbjct: 129 VTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLA 188

Query: 207 PYCITKFGVEAFSDCLRYEMY---PLGVKVSVVEPGNFIAATSLY 248
            YC +KF    F++ +  E +     G+K ++V P  F   T ++
Sbjct: 189 DYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCP--FFIKTGMF 231


>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
           sapiens]
          Length = 330

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 65/231 (28%), Positives = 102/231 (44%), Gaps = 38/231 (16%)

Query: 38  FIP-IGRRTYASAAEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGV 96
           FIP +G R  A   +  G  AV V+G   G G + A+ L S+G  +              
Sbjct: 52  FIPRLGSR--ADLIKQYGRWAV-VSGATDGIGKAYAEELASRGLNII------------- 95

Query: 97  KELDSLNSDRLRTVQLNVCSSEEVEKVVEI------------VRSSLKDPEKGMWGLVNN 144
             L S N ++L+ V  ++  + +VE  + +            +R +LKD + G+  LVNN
Sbjct: 96  --LISRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGI--LVNN 151

Query: 145 AGISTFGEVEFTSLETYK--QVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMA 201
            G+       FT L   K   +  VN+     M    LP ++ R KG +V ISS      
Sbjct: 152 VGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKP 211

Query: 202 NPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLYSPES 252
            P  + +  +K  ++ FS  L+YE    G+ V  + P  F  ATS+ +P +
Sbjct: 212 TPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIP--FYVATSMTAPSN 260


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 49/194 (25%), Positives = 90/194 (46%), Gaps = 23/194 (11%)

Query: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRL--- 107
           +P+ +K  LVT    G GF++A+ L             +D+ H  V      N D+    
Sbjct: 28  DPLTNKVALVTASTDGIGFAIARRL------------AQDRAHVVVSSRKQQNVDQAVAT 75

Query: 108 -----RTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTF-GEVEFTSLETY 161
                 +V   VC   + E    +V  ++K    G+  LV+NA ++ F G +   + E +
Sbjct: 76  LQGEGLSVTGTVCHVGKAEDRERLVAMAVK-LHGGIDILVSNAAVNPFFGSLMDVTEEVW 134

Query: 162 KQVAEVNLWGTVRMTKSFLP-LIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSD 220
            +  ++N+     MTK+ +P + +R  G VV +SS+     +P  SPY ++K  +   ++
Sbjct: 135 DKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNN 194

Query: 221 CLRYEMYPLGVKVS 234
            L  E+ P  ++V+
Sbjct: 195 TLAIELAPRNIRVN 208


>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
           sapiens]
          Length = 315

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 46/178 (25%), Positives = 82/178 (46%), Gaps = 4/178 (2%)

Query: 58  VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117
           VL+TG ++G G  LA H    G  +      +      V     L + ++  +  ++ S 
Sbjct: 32  VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91

Query: 118 EEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTK 177
           E  E VV+     L   +   + ++N+ G +  G     S +  + + +VN    V++T 
Sbjct: 92  EAPESVVQFALDKLGGLD---YLVLNHIGGAPAG-TRARSPQATRWLMQVNFVSYVQLTS 147

Query: 178 SFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSV 235
             LP +  +KG +V +SS+LGR+     +PY   KF ++ F   LR E+    V V++
Sbjct: 148 RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAI 205


>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
           sapiens]
          Length = 286

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 46/178 (25%), Positives = 82/178 (46%), Gaps = 4/178 (2%)

Query: 58  VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117
           VL+TG ++G G  LA H    G  +      +      V     L + ++  +  ++ S 
Sbjct: 32  VLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADMASP 91

Query: 118 EEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTK 177
           E  E VV+     L   +   + ++N+ G +  G     S +  + + +VN    V++T 
Sbjct: 92  EAPESVVQFALDKLGGLD---YLVLNHIGGAPAG-TRARSPQATRWLMQVNFVSYVQLTS 147

Query: 178 SFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSV 235
             LP +  +KG +V +SS+LGR+     +PY   KF ++ F   LR E+    V V++
Sbjct: 148 RALPSLTDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNVAI 205


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 43/185 (23%), Positives = 79/185 (42%), Gaps = 4/185 (2%)

Query: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
           E +  K V+VTG   G G  +A HL   G  V      K+     V     L +     +
Sbjct: 30  EMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYI 89

Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLW 170
              +      E+ V      +   +  +   + N  ++ F +     +   ++  EVN  
Sbjct: 90  AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHD----DIHHVRKSMEVNFL 145

Query: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
             V +T + LP+++++ G +V +SS+ G++A P  + Y  +KF ++ F   +R E     
Sbjct: 146 SYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSR 205

Query: 231 VKVSV 235
           V VS+
Sbjct: 206 VNVSI 210


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 43/185 (23%), Positives = 79/185 (42%), Gaps = 4/185 (2%)

Query: 51  EPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTV 110
           E +  K V+VTG   G G  +A HL   G  V      K+     V     L +     +
Sbjct: 30  EMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYI 89

Query: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVNLW 170
              +      E+ V      +   +  +   + N  ++ F +     +   ++  EVN  
Sbjct: 90  AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHD----DIHHVRKSMEVNFL 145

Query: 171 GTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLG 230
             V +T + LP+++++ G +V +SS+ G++A P  + Y  +KF ++ F   +R E     
Sbjct: 146 SYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSR 205

Query: 231 VKVSV 235
           V VS+
Sbjct: 206 VNVSI 210


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 56/219 (25%), Positives = 100/219 (45%), Gaps = 14/219 (6%)

Query: 55  SKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDR------LR 108
           S   LVTG  SG G +++  L  +G  V A  L +    + V+ L    S          
Sbjct: 11  SALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHA 70

Query: 109 TVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVAEVN 168
             Q +V  +     ++E V++    P   +   V+ AGI+    +   S + + +V  VN
Sbjct: 71  AFQADVSEARAARCLLEQVQACFSRPPSVV---VSCAGITQDEFLLHMSEDDWDKVIAVN 127

Query: 169 LWGTVRMTKSFLPLI--RRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEM 226
           L GT  +T++    +     +G ++NISS++G++ N  ++ Y  +K GV   +     E+
Sbjct: 128 LKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAREL 187

Query: 227 YPLGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELP 265
              G++ + V PG FIA     + +  Q +  K+ E +P
Sbjct: 188 GRHGIRCNSVLPG-FIATP--MTQKVPQKVVDKITEMIP 223


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,447,079
Number of Sequences: 37866
Number of extensions: 518686
Number of successful extensions: 1440
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 1302
Number of HSP's gapped (non-prelim): 79
length of query: 343
length of database: 18,247,518
effective HSP length: 103
effective length of query: 240
effective length of database: 14,347,320
effective search space: 3443356800
effective search space used: 3443356800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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