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Search of human proteins with 17511435
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|17511435 roundabout homolog 4, magic roundabout [Homo
sapiens]
(1007 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens] 2058 0.0
gi|224994171 roundabout 1 isoform c [Homo sapiens] 197 5e-50
gi|19743806 roundabout 1 isoform b [Homo sapiens] 192 1e-48
gi|4506569 roundabout 1 isoform a [Homo sapiens] 192 1e-48
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 192 2e-48
gi|224994173 roundabout 1 isoform d [Homo sapiens] 191 3e-48
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 182 2e-45
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 176 1e-43
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 157 5e-38
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 157 5e-38
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 115 2e-25
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 115 2e-25
gi|109150416 peroxidasin [Homo sapiens] 103 1e-21
gi|119220552 sidekick 1 [Homo sapiens] 101 3e-21
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 100 5e-21
gi|126517478 peroxidasin homolog-like [Homo sapiens] 99 2e-20
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 98 4e-20
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 97 6e-20
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 97 6e-20
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 97 8e-20
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 97 8e-20
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 96 1e-19
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 96 1e-19
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 96 1e-19
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 96 1e-19
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 96 1e-19
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 96 1e-19
gi|7657359 contactin 5 isoform long [Homo sapiens] 95 3e-19
gi|28373129 contactin 5 isoform short [Homo sapiens] 95 3e-19
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 94 5e-19
>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
Length = 1007
Score = 2058 bits (5331), Expect = 0.0
Identities = 1007/1007 (100%), Positives = 1007/1007 (100%)
Query: 1 MGSGGDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPP 60
MGSGGDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPP
Sbjct: 1 MGSGGDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPP 60
Query: 61 PTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRL 120
PTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRL
Sbjct: 61 PTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRL 120
Query: 121 GTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLAL 180
GTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLAL
Sbjct: 121 GTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLAL 180
Query: 181 QPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAV 240
QPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAV
Sbjct: 181 QPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAV 240
Query: 241 RIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEE 300
RIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEE
Sbjct: 241 RIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEE 300
Query: 301 LLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGN 360
LLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGN
Sbjct: 301 LLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGN 360
Query: 361 GTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIATHMPGSYCVQV 420
GTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIATHMPGSYCVQV
Sbjct: 361 GTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIATHMPGSYCVQV 420
Query: 421 AAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRPEVIATCGVALWL 480
AAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRPEVIATCGVALWL
Sbjct: 421 AAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRPEVIATCGVALWL 480
Query: 481 LLLGTAVCIHRRRRARVHLGPGLYRYTSEDAILKHRMDHSDSQWLADTWRSTSGSRDLSS 540
LLLGTAVCIHRRRRARVHLGPGLYRYTSEDAILKHRMDHSDSQWLADTWRSTSGSRDLSS
Sbjct: 481 LLLGTAVCIHRRRRARVHLGPGLYRYTSEDAILKHRMDHSDSQWLADTWRSTSGSRDLSS 540
Query: 541 SSSLSSRLGADARDPLDCRRSLLSWDSRSPGVPLLPDTSTFYGSLIAELPSSTPARPSPQ 600
SSSLSSRLGADARDPLDCRRSLLSWDSRSPGVPLLPDTSTFYGSLIAELPSSTPARPSPQ
Sbjct: 541 SSSLSSRLGADARDPLDCRRSLLSWDSRSPGVPLLPDTSTFYGSLIAELPSSTPARPSPQ 600
Query: 601 VPAVRRLPPQLAQLSSPCSSSDSLCSRRGLSSPRLSLAPAEAWKAKKKQELQHANSSPLL 660
VPAVRRLPPQLAQLSSPCSSSDSLCSRRGLSSPRLSLAPAEAWKAKKKQELQHANSSPLL
Sbjct: 601 VPAVRRLPPQLAQLSSPCSSSDSLCSRRGLSSPRLSLAPAEAWKAKKKQELQHANSSPLL 660
Query: 661 RGSHSLELRACELGNRGSKNLSQSPGAVPQALVAWRALGPKLLSSSNELVTRHLPPAPLF 720
RGSHSLELRACELGNRGSKNLSQSPGAVPQALVAWRALGPKLLSSSNELVTRHLPPAPLF
Sbjct: 661 RGSHSLELRACELGNRGSKNLSQSPGAVPQALVAWRALGPKLLSSSNELVTRHLPPAPLF 720
Query: 721 PHETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSS 780
PHETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSS
Sbjct: 721 PHETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSS 780
Query: 781 SLSSLGEDQDSVLTPEEVALCLELSEGEETPRNSVSPMPRAPSPPTTYGYISVPTASEFT 840
SLSSLGEDQDSVLTPEEVALCLELSEGEETPRNSVSPMPRAPSPPTTYGYISVPTASEFT
Sbjct: 781 SLSSLGEDQDSVLTPEEVALCLELSEGEETPRNSVSPMPRAPSPPTTYGYISVPTASEFT 840
Query: 841 DMGRTGGGVGPKGGVLLCPPRPCLTPTPSEGSLANGWGSASEDNAASARASLVSSSDGSF 900
DMGRTGGGVGPKGGVLLCPPRPCLTPTPSEGSLANGWGSASEDNAASARASLVSSSDGSF
Sbjct: 841 DMGRTGGGVGPKGGVLLCPPRPCLTPTPSEGSLANGWGSASEDNAASARASLVSSSDGSF 900
Query: 901 LADAHFARALAVAVDSFGFGLEPREADCVFIDASSPPSPRDEIFLTPNLSLPLWEWRPDW 960
LADAHFARALAVAVDSFGFGLEPREADCVFIDASSPPSPRDEIFLTPNLSLPLWEWRPDW
Sbjct: 901 LADAHFARALAVAVDSFGFGLEPREADCVFIDASSPPSPRDEIFLTPNLSLPLWEWRPDW 960
Query: 961 LEDMEVSHTQRLGRGMPPWPPDSQISSQRSQLHCRMPKAGASPVDYS 1007
LEDMEVSHTQRLGRGMPPWPPDSQISSQRSQLHCRMPKAGASPVDYS
Sbjct: 961 LEDMEVSHTQRLGRGMPPWPPDSQISSQRSQLHCRMPKAGASPVDYS 1007
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 197 bits (500), Expect = 5e-50
Identities = 277/1075 (25%), Positives = 417/1075 (38%), Gaps = 145/1075 (13%)
Query: 26 MAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85
+A PP I P +Q G +SC A+G P PTI W +G +S D
Sbjct: 413 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST---------QD 463
Query: 86 GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQI---- 141
+ L+ G A D G YTC AS G A S + ++F +
Sbjct: 464 SRIKQLE---NGVLQIRYAKLGDTGRYTCIASTPSGEAT-----WSAYIEVQEFGVPVQP 515
Query: 142 -QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLA------LQPGRHTVSGGSLLM 194
+P D + E T+SW + A ++ H +
Sbjct: 516 PRPTDPNLIPSAPSKPEVTDV-SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 574
Query: 195 ARAEKSDEGTYMCVATNSAGHRESRAARV-SIQEPQDYTEPV------------------ 235
A K++ + N+ RAA I +P ++PV
Sbjct: 575 AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 634
Query: 236 -ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQG 294
EL + L N T+L+ E + W V + Q Y L+R A G+
Sbjct: 635 RELGNAVLHLHNPTVLSSSSIE---------VHWTVDQQSQYIQGYKILYRPSGANHGE- 684
Query: 295 APWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ 352
+ W E S + L G +YE K RP +G DS + + E+ PSAPPQ
Sbjct: 685 SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 744
Query: 353 EVTLKP--GNGT-VFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIA 409
VT+ GNGT + VSW PPP + NG+++ Y+VW LGN + N TV G + I
Sbjct: 745 GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 804
Query: 410 THMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468
+PG Y V+VAA TGAG+G S P + L+ + E +Q+ +K+P
Sbjct: 805 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS---LAQQISDVVKQP 861
Query: 469 EVIATCGVALWLLLLGTAVCIHRRRRARVHLG---PGLYRYTSE---DAI-------LKH 515
IA G A W++L+ ++ ++R R+ R L G+ + T + +A+ L +
Sbjct: 862 AFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQRGGEAVSSGGRPGLLN 921
Query: 516 RMDHSDSQWLADTWRSTSGS-RDLSSSSSLSSRLGADAR-----DPLDCRRSLLSWDSRS 569
+ + WLADTW +T + D S S + +D+ P DC + +
Sbjct: 922 ISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNK 981
Query: 570 PGVPLLPDTSTFYGSL-IAELPSSTPARPSPQVPAVRRLPPQLAQLSSPCSSSDSLCSRR 628
+LP+ ST YG + ++ + SP + R + P + +P +++ + S
Sbjct: 982 QTNLMLPE-STVYGDVDLSNKINEMKTFNSPNLKDGRFVNP--SGQPTPYATTQLIQSNL 1038
Query: 629 GLSSPRLSLAPAEA-WK--AKKKQELQHANSSPLLRGSHSLELRACEL------------ 673
+ S E WK ++KQE+ + + + + + RA +
Sbjct: 1039 SNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYD 1098
Query: 674 GNRGSKNLSQSPGAVPQALVAWR--ALGPKLLSSSNELVTRHLPPAPLFPHETPPTQSQQ 731
N G S G+ + A PK+ LPP P H P + S++
Sbjct: 1099 QNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP--AHPPPHSNSEE 1156
Query: 732 TQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSSSLSSLGEDQDS 791
V + P P + + P SS + S +
Sbjct: 1157 YNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTA 1216
Query: 792 VLTP---EEVALCLE--------LSEGEETPRNSVS--PMPRAPSPPTTYGYISVPTASE 838
LTP EE+ L+ + + R VS P PR SPP TYGYIS P S+
Sbjct: 1217 TLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSD 1276
Query: 839 F-TDMGRTGGGVGPKGGVLLCPPRPCL-----TPTPS--------EGSLANGWGSASEDN 884
TD + R L TP S GS+ NGWGSASE++
Sbjct: 1277 MDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEED 1336
Query: 885 AASARASLVSSSDGSFLADAHFARALAVAVDSFGFGLEPRE----ADCVFIDASSPPSPR 940
S+ S VSSSDGSF DA FA+A+A A + G + R+ A AS P P
Sbjct: 1337 NISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPT 1396
Query: 941 DEIFLTPNLSLPLWE-WRPDWLEDMEVSHTQR--LGRGMPPWP-PDSQISSQRSQ 991
+ N+S + + RP + H +R +PP P P I S +Q
Sbjct: 1397 SPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQ 1451
Score = 176 bits (446), Expect = 1e-43
Identities = 92/218 (42%), Positives = 123/218 (56%), Gaps = 9/218 (4%)
Query: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
+D PP+I+ HP D + PA ++C+A G+P PTI W G+ + DP LLP
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
G+L L+ G+ D GVY C A N LG AVS A L VA+LR+DF+ P
Sbjct: 85 SGSLFFLR------IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
D++ VGE +EC PP GHPEPT+SW KDG PL + R T+ GG L++ KSD G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRI 242
Y+CV TN G RES A +++ E + + LAV +
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Score = 80.5 bits (197), Expect = 7e-15
Identities = 103/425 (24%), Positives = 160/425 (37%), Gaps = 59/425 (13%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P + P + A C+A G P PT+RW + L P + + D TL +
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIR 279
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRE--DFQIQPRDMVAV 149
+ A D+G YTC A N +G A A L+V V E F ++PRD V
Sbjct: 280 KVTA-----------GDMGSYTCVAENMVGKA-EASATLTVQVGSEPPHFVVKPRDQVVA 327
Query: 150 VGEQFTLECGPPWGHPEPTVSWWKDGKP---LALQP----GRHTVS-GGSLLMARAEKSD 201
+G T +C G+P+P + W ++G + QP R +VS G L + ++SD
Sbjct: 328 LGRTVTFQC-EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 386
Query: 202 EGTYMCVATNSAGHRESRAARVSIQEPQDYTEPV---ELLAVRIQLENVTLLNPDPAEGP 258
G Y+C N AG ++A D PV + + ++ +L+ P
Sbjct: 387 VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSP 446
Query: 259 KPRPAVWLSWKVSGPAAPAQS------YTALFRTQTAPGGQGAPWAEELLAGWQSAELGG 312
P + W+ G Q + + + A G + +A S E
Sbjct: 447 VPT----ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT--CIASTPSGEATW 500
Query: 313 LHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPA 372
+ + EF V R P+ +PSAP + TV +SW P
Sbjct: 501 SAYIEVQEFGVPVQPPRPTDPN----------LIPSAPSKPEVTDVSRNTVTLSW--QPN 548
Query: 373 ENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE---IATHMPGS-YCVQVAAVTGAGA 428
N Y + + + S ++W V E + E I P + Y V A G
Sbjct: 549 LNSGATPTSYIIEAFSHAS--GSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGI 606
Query: 429 GEPSR 433
+PS+
Sbjct: 607 SDPSQ 611
Score = 69.3 bits (168), Expect = 2e-11
Identities = 65/227 (28%), Positives = 90/227 (39%), Gaps = 25/227 (11%)
Query: 37 HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95
+P D + PA M CQ G P PTI W +G PL D + G L++
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD--DKDERITIRGGKLMITY--- 190
Query: 96 RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155
+D G Y C +N +G S A L+V + R F +P ++ V +
Sbjct: 191 --------TRKSDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAE 241
Query: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMAR-AEKSDEGTYMCVATNSAG 214
+C G P PTV W KD L R+ + L R D G+Y CVA N G
Sbjct: 242 FKCEAR-GDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 215 HRESRA---ARVSIQEPQDYTEP---VELLAVRIQLENVTLLNPDPA 255
E+ A +V + P +P V L + + NP PA
Sbjct: 299 KAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 345
Score = 68.2 bits (165), Expect = 4e-11
Identities = 81/320 (25%), Positives = 121/320 (37%), Gaps = 54/320 (16%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP +V P+DQ+ C+A+G P P I W G L
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS--------------QNLLFS 359
Query: 91 LQPP---------ARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED--- 138
QPP G +D+G Y C+ N G+ +++ A L V + D
Sbjct: 360 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK-AYLEVTDVIADRPP 418
Query: 139 --FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMA 195
+ P + V F L C G P PT+ W KDG ++ Q R + G L +
Sbjct: 419 PVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477
Query: 196 RAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPA 255
A+ D G Y C+A+ +G + +A + +QE V +Q T N P+
Sbjct: 478 YAKLGDTGRYTCIASTPSG-EATWSAYIEVQE----------FGVPVQPPRPTDPNLIPS 526
Query: 256 EGPKP------RPAVWLSWK--VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQS 307
KP R V LSW+ ++ A P F A G AE + ++
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF--SHASGSSWQTVAENVKT--ET 582
Query: 308 AELGGLHWGQDYEFKVRPSS 327
+ + GL Y F VR ++
Sbjct: 583 SAIKGLKPNAIYLFLVRAAN 602
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 192 bits (489), Expect = 1e-48
Identities = 276/1084 (25%), Positives = 414/1084 (38%), Gaps = 154/1084 (14%)
Query: 26 MAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85
+A PP I P +Q G +SC A+G P PTI W +G +S D
Sbjct: 410 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST---------QD 460
Query: 86 GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQI---- 141
+ L+ G A D G YTC AS G A S + ++F +
Sbjct: 461 SRIKQLE---NGVLQIRYAKLGDTGRYTCIASTPSGEAT-----WSAYIEVQEFGVPVQP 512
Query: 142 -QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLA------LQPGRHTVSGGSLLM 194
+P D + E T+SW + A ++ H +
Sbjct: 513 PRPTDPNLIPSAPSKPEVTDV-SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 571
Query: 195 ARAEKSDEGTYMCVATNSAGHRESRAARV-SIQEPQDYTEPV------------------ 235
A K++ + N+ RAA I +P ++PV
Sbjct: 572 AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 631
Query: 236 -ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQG 294
EL + L N T+L+ E + W V + Q Y L+R A G+
Sbjct: 632 RELGNAVLHLHNPTVLSSSSIE---------VHWTVDQQSQYIQGYKILYRPSGANHGE- 681
Query: 295 APWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ 352
+ W E S + L G +YE K RP +G DS + + E+ PSAPPQ
Sbjct: 682 SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 741
Query: 353 EVTLKP--GNGT-VFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIA 409
VT+ GNGT + VSW PPP + NG+++ Y+VW LGN + N TV G + I
Sbjct: 742 GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 801
Query: 410 THMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468
+PG Y V+VAA TGAG+G S P + L+ + E +Q+ +K+P
Sbjct: 802 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS---LAQQISDVVKQP 858
Query: 469 EVIATCGVALWLLLLGTAVCIHRRRRARVHL---------------GPGLYRYTSEDAI- 512
IA G A W++L+ ++ ++R R+ R L P + +A+
Sbjct: 859 AFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVS 918
Query: 513 ------LKHRMDHSDSQWLADTWRSTSGS-RDLSSSSSLSSRLGADAR-----DPLDCRR 560
L + + + WLADTW +T + D S S + +D+ P DC
Sbjct: 919 SGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIA 978
Query: 561 SLLSWDSRSPGVPLLPDTSTFYGSL-IAELPSSTPARPSPQVPAVRRLPPQLAQLSSPCS 619
+ + +LP+ ST YG + ++ + SP + R + P + +P +
Sbjct: 979 NYNNQLDNKQTNLMLPE-STVYGDVDLSNKINEMKTFNSPNLKDGRFVNP--SGQPTPYA 1035
Query: 620 SSDSLCSRRGLSSPRLSLAPAEA-WK--AKKKQELQHANSSPLLRGSHSLELRACEL--- 673
++ + S + S E WK ++KQE+ + + + + + RA +
Sbjct: 1036 TTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPP 1095
Query: 674 ---------GNRGSKNLSQSPGAVPQALVAWR--ALGPKLLSSSNELVTRHLPPAPLFPH 722
N G S G+ + A PK+ LPP P H
Sbjct: 1096 TIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP--AH 1153
Query: 723 ETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSSSL 782
P + S++ V + P P + + P SS +
Sbjct: 1154 PPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAA 1213
Query: 783 SSLGEDQDSVLTP---EEVALCLE--------LSEGEETPRNSVS--PMPRAPSPPTTYG 829
S + LTP EE+ L+ + + R VS P PR SPP TYG
Sbjct: 1214 VSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYG 1273
Query: 830 YISVPTASEF-TDMGRTGGGVGPKGGVLLCPPRPCL-----TPTPS--------EGSLAN 875
YIS P S+ TD + R L TP S GS+ N
Sbjct: 1274 YISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMIN 1333
Query: 876 GWGSASEDNAASARASLVSSSDGSFLADAHFARALAVAVDSFGFGLEPRE----ADCVFI 931
GWGSASE++ S+ S VSSSDGSF DA FA+A+A A + G + R+ A
Sbjct: 1334 GWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHF 1393
Query: 932 DASSPPSPRDEIFLTPNLSLPLWE-WRPDWLEDMEVSHTQR--LGRGMPPWP-PDSQISS 987
AS P P + N+S + + RP + H +R +PP P P I S
Sbjct: 1394 HASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKS 1453
Query: 988 QRSQ 991
+Q
Sbjct: 1454 PTAQ 1457
Score = 176 bits (446), Expect = 1e-43
Identities = 92/218 (42%), Positives = 123/218 (56%), Gaps = 9/218 (4%)
Query: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
+D PP+I+ HP D + PA ++C+A G+P PTI W G+ + DP LLP
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
G+L L+ G+ D GVY C A N LG AVS A L VA+LR+DF+ P
Sbjct: 85 SGSLFFLR------IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
D++ VGE +EC PP GHPEPT+SW KDG PL + R T+ GG L++ KSD G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRI 242
Y+CV TN G RES A +++ E + + LAV +
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Score = 77.4 bits (189), Expect = 6e-14
Identities = 101/423 (23%), Positives = 158/423 (37%), Gaps = 58/423 (13%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P + P + A C+A G P PT+RW + L P + + D TL +
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIR 279
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVG 151
+ A D+G YTC A N +G A A L+V F ++PRD V +G
Sbjct: 280 KVTA-----------GDMGSYTCVAENMVGKA-EASATLTVQE-PPHFVVKPRDQVVALG 326
Query: 152 EQFTLECGPPWGHPEPTVSWWKDGKP---LALQP----GRHTVS-GGSLLMARAEKSDEG 203
T +C G+P+P + W ++G + QP R +VS G L + ++SD G
Sbjct: 327 RTVTFQC-EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 385
Query: 204 TYMCVATNSAGHRESRAARVSIQEPQDYTEPV---ELLAVRIQLENVTLLNPDPAEGPKP 260
Y+C N AG ++A D PV + + ++ +L+ P P
Sbjct: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 445
Query: 261 RPAVWLSWKVSGPAAPAQS------YTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLH 314
+ W+ G Q + + + A G + +A S E
Sbjct: 446 T----ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT--CIASTPSGEATWSA 499
Query: 315 WGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAEN 374
+ + EF V R P+ +PSAP + TV +SW P N
Sbjct: 500 YIEVQEFGVPVQPPRPTDPN----------LIPSAPSKPEVTDVSRNTVTLSW--QPNLN 547
Query: 375 HNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE---IATHMPGS-YCVQVAAVTGAGAGE 430
Y + + + S ++W V E + E I P + Y V A G +
Sbjct: 548 SGATPTSYIIEAFSHAS--GSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD 605
Query: 431 PSR 433
PS+
Sbjct: 606 PSQ 608
Score = 73.6 bits (179), Expect = 9e-13
Identities = 65/225 (28%), Positives = 93/225 (41%), Gaps = 24/225 (10%)
Query: 37 HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95
+P D + PA M CQ G P PTI W +G PL D + G L++
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD--DKDERITIRGGKLMITY--- 190
Query: 96 RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155
+D G Y C +N +G S A L+V + R F +P ++ V +
Sbjct: 191 --------TRKSDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAE 241
Query: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMAR-AEKSDEGTYMCVATNSAG 214
+C G P PTV W KD L R+ + L R D G+Y CVA N G
Sbjct: 242 FKCEAR-GDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 215 HRESRAARVSIQEPQDYT----EPVELLAVRIQLENVTLLNPDPA 255
E+ +A +++QEP + + V L + + NP PA
Sbjct: 299 KAEA-SATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 342
Score = 68.2 bits (165), Expect = 4e-11
Identities = 81/320 (25%), Positives = 121/320 (37%), Gaps = 54/320 (16%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP +V P+DQ+ C+A+G P P I W G L
Sbjct: 311 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS--------------QNLLFS 356
Query: 91 LQPP---------ARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED--- 138
QPP G +D+G Y C+ N G+ +++ A L V + D
Sbjct: 357 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK-AYLEVTDVIADRPP 415
Query: 139 --FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMA 195
+ P + V F L C G P PT+ W KDG ++ Q R + G L +
Sbjct: 416 PVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 474
Query: 196 RAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPA 255
A+ D G Y C+A+ +G + +A + +QE V +Q T N P+
Sbjct: 475 YAKLGDTGRYTCIASTPSG-EATWSAYIEVQE----------FGVPVQPPRPTDPNLIPS 523
Query: 256 EGPKP------RPAVWLSWK--VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQS 307
KP R V LSW+ ++ A P F A G AE + ++
Sbjct: 524 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF--SHASGSSWQTVAENVKT--ET 579
Query: 308 AELGGLHWGQDYEFKVRPSS 327
+ + GL Y F VR ++
Sbjct: 580 SAIKGLKPNAIYLFLVRAAN 599
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 192 bits (489), Expect = 1e-48
Identities = 276/1084 (25%), Positives = 414/1084 (38%), Gaps = 154/1084 (14%)
Query: 26 MAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85
+A PP I P +Q G +SC A+G P PTI W +G +S D
Sbjct: 449 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST---------QD 499
Query: 86 GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQI---- 141
+ L+ G A D G YTC AS G A S + ++F +
Sbjct: 500 SRIKQLE---NGVLQIRYAKLGDTGRYTCIASTPSGEAT-----WSAYIEVQEFGVPVQP 551
Query: 142 -QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLA------LQPGRHTVSGGSLLM 194
+P D + E T+SW + A ++ H +
Sbjct: 552 PRPTDPNLIPSAPSKPEVTDV-SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 610
Query: 195 ARAEKSDEGTYMCVATNSAGHRESRAARV-SIQEPQDYTEPV------------------ 235
A K++ + N+ RAA I +P ++PV
Sbjct: 611 AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 670
Query: 236 -ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQG 294
EL + L N T+L+ E + W V + Q Y L+R A G+
Sbjct: 671 RELGNAVLHLHNPTVLSSSSIE---------VHWTVDQQSQYIQGYKILYRPSGANHGE- 720
Query: 295 APWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ 352
+ W E S + L G +YE K RP +G DS + + E+ PSAPPQ
Sbjct: 721 SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 780
Query: 353 EVTLKP--GNGT-VFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIA 409
VT+ GNGT + VSW PPP + NG+++ Y+VW LGN + N TV G + I
Sbjct: 781 GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 840
Query: 410 THMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468
+PG Y V+VAA TGAG+G S P + L+ + E +Q+ +K+P
Sbjct: 841 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS---LAQQISDVVKQP 897
Query: 469 EVIATCGVALWLLLLGTAVCIHRRRRARVHL---------------GPGLYRYTSEDAI- 512
IA G A W++L+ ++ ++R R+ R L P + +A+
Sbjct: 898 AFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVS 957
Query: 513 ------LKHRMDHSDSQWLADTWRSTSGS-RDLSSSSSLSSRLGADAR-----DPLDCRR 560
L + + + WLADTW +T + D S S + +D+ P DC
Sbjct: 958 SGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIA 1017
Query: 561 SLLSWDSRSPGVPLLPDTSTFYGSL-IAELPSSTPARPSPQVPAVRRLPPQLAQLSSPCS 619
+ + +LP+ ST YG + ++ + SP + R + P + +P +
Sbjct: 1018 NYNNQLDNKQTNLMLPE-STVYGDVDLSNKINEMKTFNSPNLKDGRFVNP--SGQPTPYA 1074
Query: 620 SSDSLCSRRGLSSPRLSLAPAEA-WK--AKKKQELQHANSSPLLRGSHSLELRACEL--- 673
++ + S + S E WK ++KQE+ + + + + + RA +
Sbjct: 1075 TTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPP 1134
Query: 674 ---------GNRGSKNLSQSPGAVPQALVAWR--ALGPKLLSSSNELVTRHLPPAPLFPH 722
N G S G+ + A PK+ LPP P H
Sbjct: 1135 TIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP--AH 1192
Query: 723 ETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSSSL 782
P + S++ V + P P + + P SS +
Sbjct: 1193 PPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAA 1252
Query: 783 SSLGEDQDSVLTP---EEVALCLE--------LSEGEETPRNSVS--PMPRAPSPPTTYG 829
S + LTP EE+ L+ + + R VS P PR SPP TYG
Sbjct: 1253 VSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYG 1312
Query: 830 YISVPTASEF-TDMGRTGGGVGPKGGVLLCPPRPCL-----TPTPS--------EGSLAN 875
YIS P S+ TD + R L TP S GS+ N
Sbjct: 1313 YISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMIN 1372
Query: 876 GWGSASEDNAASARASLVSSSDGSFLADAHFARALAVAVDSFGFGLEPRE----ADCVFI 931
GWGSASE++ S+ S VSSSDGSF DA FA+A+A A + G + R+ A
Sbjct: 1373 GWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHF 1432
Query: 932 DASSPPSPRDEIFLTPNLSLPLWE-WRPDWLEDMEVSHTQR--LGRGMPPWP-PDSQISS 987
AS P P + N+S + + RP + H +R +PP P P I S
Sbjct: 1433 HASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKS 1492
Query: 988 QRSQ 991
+Q
Sbjct: 1493 PTAQ 1496
Score = 176 bits (446), Expect = 1e-43
Identities = 92/218 (42%), Positives = 123/218 (56%), Gaps = 9/218 (4%)
Query: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
+D PP+I+ HP D + PA ++C+A G+P PTI W G+ + DP LLP
Sbjct: 64 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 123
Query: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
G+L L+ G+ D GVY C A N LG AVS A L VA+LR+DF+ P
Sbjct: 124 SGSLFFLR------IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
D++ VGE +EC PP GHPEPT+SW KDG PL + R T+ GG L++ KSD G
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 237
Query: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRI 242
Y+CV TN G RES A +++ E + + LAV +
Sbjct: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 275
Score = 77.4 bits (189), Expect = 6e-14
Identities = 101/423 (23%), Positives = 158/423 (37%), Gaps = 58/423 (13%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P + P + A C+A G P PT+RW + L P + + D TL +
Sbjct: 262 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIR 318
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVG 151
+ A D+G YTC A N +G A A L+V F ++PRD V +G
Sbjct: 319 KVTA-----------GDMGSYTCVAENMVGKA-EASATLTVQE-PPHFVVKPRDQVVALG 365
Query: 152 EQFTLECGPPWGHPEPTVSWWKDGKP---LALQP----GRHTVS-GGSLLMARAEKSDEG 203
T +C G+P+P + W ++G + QP R +VS G L + ++SD G
Sbjct: 366 RTVTFQC-EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 424
Query: 204 TYMCVATNSAGHRESRAARVSIQEPQDYTEPV---ELLAVRIQLENVTLLNPDPAEGPKP 260
Y+C N AG ++A D PV + + ++ +L+ P P
Sbjct: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 484
Query: 261 RPAVWLSWKVSGPAAPAQS------YTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLH 314
+ W+ G Q + + + A G + +A S E
Sbjct: 485 T----ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT--CIASTPSGEATWSA 538
Query: 315 WGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAEN 374
+ + EF V R P+ +PSAP + TV +SW P N
Sbjct: 539 YIEVQEFGVPVQPPRPTDPN----------LIPSAPSKPEVTDVSRNTVTLSW--QPNLN 586
Query: 375 HNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE---IATHMPGS-YCVQVAAVTGAGAGE 430
Y + + + S ++W V E + E I P + Y V A G +
Sbjct: 587 SGATPTSYIIEAFSHAS--GSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD 644
Query: 431 PSR 433
PS+
Sbjct: 645 PSQ 647
Score = 73.6 bits (179), Expect = 9e-13
Identities = 65/225 (28%), Positives = 93/225 (41%), Gaps = 24/225 (10%)
Query: 37 HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95
+P D + PA M CQ G P PTI W +G PL D + G L++
Sbjct: 175 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD--DKDERITIRGGKLMITY--- 229
Query: 96 RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155
+D G Y C +N +G S A L+V + R F +P ++ V +
Sbjct: 230 --------TRKSDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAE 280
Query: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMAR-AEKSDEGTYMCVATNSAG 214
+C G P PTV W KD L R+ + L R D G+Y CVA N G
Sbjct: 281 FKCEAR-GDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 337
Query: 215 HRESRAARVSIQEPQDYT----EPVELLAVRIQLENVTLLNPDPA 255
E+ +A +++QEP + + V L + + NP PA
Sbjct: 338 KAEA-SATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 381
Score = 68.2 bits (165), Expect = 4e-11
Identities = 81/320 (25%), Positives = 121/320 (37%), Gaps = 54/320 (16%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP +V P+DQ+ C+A+G P P I W G L
Sbjct: 350 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS--------------QNLLFS 395
Query: 91 LQPP---------ARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED--- 138
QPP G +D+G Y C+ N G+ +++ A L V + D
Sbjct: 396 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK-AYLEVTDVIADRPP 454
Query: 139 --FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMA 195
+ P + V F L C G P PT+ W KDG ++ Q R + G L +
Sbjct: 455 PVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 513
Query: 196 RAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPA 255
A+ D G Y C+A+ +G + +A + +QE V +Q T N P+
Sbjct: 514 YAKLGDTGRYTCIASTPSG-EATWSAYIEVQE----------FGVPVQPPRPTDPNLIPS 562
Query: 256 EGPKP------RPAVWLSWK--VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQS 307
KP R V LSW+ ++ A P F A G AE + ++
Sbjct: 563 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF--SHASGSSWQTVAENVKT--ET 618
Query: 308 AELGGLHWGQDYEFKVRPSS 327
+ + GL Y F VR ++
Sbjct: 619 SAIKGLKPNAIYLFLVRAAN 638
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 192 bits (487), Expect = 2e-48
Identities = 276/1084 (25%), Positives = 413/1084 (38%), Gaps = 154/1084 (14%)
Query: 26 MAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85
+A PP I P +Q G +SC A+G P PTI W +G +S D
Sbjct: 413 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST---------QD 463
Query: 86 GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQI---- 141
+ L+ G A D G YTC AS G A S + ++F +
Sbjct: 464 SRIKQLE---NGVLQIRYAKLGDTGRYTCIASTPSGEAT-----WSAYIEVQEFGVPVQP 515
Query: 142 -QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLA------LQPGRHTVSGGSLLM 194
+P D + E T+SW + A ++ H +
Sbjct: 516 PRPTDPNLIPSAPSKPEVTDV-SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 574
Query: 195 ARAEKSDEGTYMCVATNSAGHRESRAARV-SIQEPQDYTEPV------------------ 235
A K++ + N+ RAA I +P ++PV
Sbjct: 575 AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 634
Query: 236 -ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQG 294
EL + L N T+L+ E + W V + Q Y L+R A G+
Sbjct: 635 RELGNAVLHLHNPTVLSSSSIE---------VHWTVDQQSQYIQGYKILYRPSGANHGE- 684
Query: 295 APWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ 352
+ W E S + L G +YE K RP +G DS + + E+ PSAPPQ
Sbjct: 685 SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 744
Query: 353 EVTLKP--GNGT-VFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIA 409
VT+ GNGT + VSW PPP + NG+++ Y+VW LGN + N TV G + I
Sbjct: 745 GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 804
Query: 410 THMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468
+PG Y V+VAA TGAG+G S P + L+ + E +Q+ +K+P
Sbjct: 805 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS---LAQQISDVVKQP 861
Query: 469 EVIATCGVALWLLLLGTAVCIHRRRRARVHL---------------GPGLYRYTSEDAI- 512
IA G A W++L+ ++ ++R R+ R L P + +A+
Sbjct: 862 AFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVS 921
Query: 513 ------LKHRMDHSDSQWLADTWRSTSGS-RDLSSSSSLSSRLGADAR-----DPLDCRR 560
L + + + WLADTW +T + D S S + +D+ P DC
Sbjct: 922 SGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIA 981
Query: 561 SLLSWDSRSPGVPLLPDTSTFYGSL-IAELPSSTPARPSPQVPAVRRLPPQLAQLSSPCS 619
+ + +LP+ ST YG + ++ + SP + R + P + +P +
Sbjct: 982 NYNNQLDNKQTNLMLPE-STVYGDVDLSNKINEMKTFNSPNLKDGRFVNP--SGQPTPYA 1038
Query: 620 SSDSLCSRRGLSSPRLSLAPAEA-WK--AKKKQELQHANSSPLLRGSHSLELRACEL--- 673
++ + S + S E WK ++KQE+ + + + + + RA +
Sbjct: 1039 TTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPP 1098
Query: 674 ---------GNRGSKNLSQSPGAVPQALVAWR--ALGPKLLSSSNELVTRHLPPAPLFPH 722
N G S G+ + A PK+ LPP P H
Sbjct: 1099 TIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP--AH 1156
Query: 723 ETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSSSL 782
P + S++ V + P P + P SS +
Sbjct: 1157 PPPHSNSEEYNISVDESYDQEMPCPVPPARTYLQQDELEEEEDERGPTPPVRGAASSPAA 1216
Query: 783 SSLGEDQDSVLTP---EEVALCLE--------LSEGEETPRNSVS--PMPRAPSPPTTYG 829
S + LTP EE+ L+ + + R VS P PR SPP TYG
Sbjct: 1217 VSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYG 1276
Query: 830 YISVPTASEF-TDMGRTGGGVGPKGGVLLCPPRPCL-----TPTPS--------EGSLAN 875
YIS P S+ TD + R L TP S GS+ N
Sbjct: 1277 YISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMIN 1336
Query: 876 GWGSASEDNAASARASLVSSSDGSFLADAHFARALAVAVDSFGFGLEPRE----ADCVFI 931
GWGSASE++ S+ S VSSSDGSF DA FA+A+A A + G + R+ A
Sbjct: 1337 GWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHF 1396
Query: 932 DASSPPSPRDEIFLTPNLSLPLWE-WRPDWLEDMEVSHTQR--LGRGMPPWP-PDSQISS 987
AS P P + N+S + + RP + H +R +PP P P I S
Sbjct: 1397 HASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKS 1456
Query: 988 QRSQ 991
+Q
Sbjct: 1457 PTAQ 1460
Score = 176 bits (446), Expect = 1e-43
Identities = 92/218 (42%), Positives = 123/218 (56%), Gaps = 9/218 (4%)
Query: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
+D PP+I+ HP D + PA ++C+A G+P PTI W G+ + DP LLP
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
G+L L+ G+ D GVY C A N LG AVS A L VA+LR+DF+ P
Sbjct: 85 SGSLFFLR------IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
D++ VGE +EC PP GHPEPT+SW KDG PL + R T+ GG L++ KSD G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRI 242
Y+CV TN G RES A +++ E + + LAV +
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Score = 80.5 bits (197), Expect = 7e-15
Identities = 103/425 (24%), Positives = 160/425 (37%), Gaps = 59/425 (13%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P + P + A C+A G P PT+RW + L P + + D TL +
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIR 279
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRE--DFQIQPRDMVAV 149
+ A D+G YTC A N +G A A L+V V E F ++PRD V
Sbjct: 280 KVTA-----------GDMGSYTCVAENMVGKA-EASATLTVQVGSEPPHFVVKPRDQVVA 327
Query: 150 VGEQFTLECGPPWGHPEPTVSWWKDGKP---LALQP----GRHTVS-GGSLLMARAEKSD 201
+G T +C G+P+P + W ++G + QP R +VS G L + ++SD
Sbjct: 328 LGRTVTFQC-EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 386
Query: 202 EGTYMCVATNSAGHRESRAARVSIQEPQDYTEPV---ELLAVRIQLENVTLLNPDPAEGP 258
G Y+C N AG ++A D PV + + ++ +L+ P
Sbjct: 387 VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSP 446
Query: 259 KPRPAVWLSWKVSGPAAPAQS------YTALFRTQTAPGGQGAPWAEELLAGWQSAELGG 312
P + W+ G Q + + + A G + +A S E
Sbjct: 447 VPT----ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT--CIASTPSGEATW 500
Query: 313 LHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPA 372
+ + EF V R P+ +PSAP + TV +SW P
Sbjct: 501 SAYIEVQEFGVPVQPPRPTDPN----------LIPSAPSKPEVTDVSRNTVTLSW--QPN 548
Query: 373 ENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE---IATHMPGS-YCVQVAAVTGAGA 428
N Y + + + S ++W V E + E I P + Y V A G
Sbjct: 549 LNSGATPTSYIIEAFSHAS--GSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGI 606
Query: 429 GEPSR 433
+PS+
Sbjct: 607 SDPSQ 611
Score = 69.3 bits (168), Expect = 2e-11
Identities = 65/227 (28%), Positives = 90/227 (39%), Gaps = 25/227 (11%)
Query: 37 HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95
+P D + PA M CQ G P PTI W +G PL D + G L++
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD--DKDERITIRGGKLMITY--- 190
Query: 96 RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155
+D G Y C +N +G S A L+V + R F +P ++ V +
Sbjct: 191 --------TRKSDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAE 241
Query: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMAR-AEKSDEGTYMCVATNSAG 214
+C G P PTV W KD L R+ + L R D G+Y CVA N G
Sbjct: 242 FKCEAR-GDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 215 HRESRA---ARVSIQEPQDYTEP---VELLAVRIQLENVTLLNPDPA 255
E+ A +V + P +P V L + + NP PA
Sbjct: 299 KAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 345
Score = 68.2 bits (165), Expect = 4e-11
Identities = 81/320 (25%), Positives = 121/320 (37%), Gaps = 54/320 (16%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP +V P+DQ+ C+A+G P P I W G L
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS--------------QNLLFS 359
Query: 91 LQPP---------ARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED--- 138
QPP G +D+G Y C+ N G+ +++ A L V + D
Sbjct: 360 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK-AYLEVTDVIADRPP 418
Query: 139 --FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMA 195
+ P + V F L C G P PT+ W KDG ++ Q R + G L +
Sbjct: 419 PVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477
Query: 196 RAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPA 255
A+ D G Y C+A+ +G + +A + +QE V +Q T N P+
Sbjct: 478 YAKLGDTGRYTCIASTPSG-EATWSAYIEVQE----------FGVPVQPPRPTDPNLIPS 526
Query: 256 EGPKP------RPAVWLSWK--VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQS 307
KP R V LSW+ ++ A P F A G AE + ++
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF--SHASGSSWQTVAENVKT--ET 582
Query: 308 AELGGLHWGQDYEFKVRPSS 327
+ + GL Y F VR ++
Sbjct: 583 SAIKGLKPNAIYLFLVRAAN 602
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 191 bits (485), Expect = 3e-48
Identities = 271/1054 (25%), Positives = 405/1054 (38%), Gaps = 158/1054 (14%)
Query: 26 MAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85
+A PP I P +Q G +SC A+G P PTI W +G +S D
Sbjct: 413 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST---------QD 463
Query: 86 GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQI---- 141
+ L+ G A D G YTC AS G A S + ++F +
Sbjct: 464 SRIKQLE---NGVLQIRYAKLGDTGRYTCIASTPSGEAT-----WSAYIEVQEFGVPVQP 515
Query: 142 -QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLA------LQPGRHTVSGGSLLM 194
+P D + E T+SW + A ++ H +
Sbjct: 516 PRPTDPNLIPSAPSKPEVTDV-SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 574
Query: 195 ARAEKSDEGTYMCVATNSAGHRESRAARV-SIQEPQDYTEPV------------------ 235
A K++ + N+ RAA I +P ++PV
Sbjct: 575 AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 634
Query: 236 -ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQG 294
EL + L N T+L+ E + W V + Q Y L+R A G+
Sbjct: 635 RELGNAVLHLHNPTVLSSSSIE---------VHWTVDQQSQYIQGYKILYRPSGANHGE- 684
Query: 295 APWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ 352
+ W E S + L G +YE K RP +G DS + + E+ PSAPPQ
Sbjct: 685 SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 744
Query: 353 EVTLKP--GNGT-VFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIA 409
VT+ GNGT + VSW PPP + NG+++ Y+VW LGN + N TV G + I
Sbjct: 745 GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 804
Query: 410 THMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468
+PG Y V+VAA TGAG+G S P + L+ + E +Q+ +K+P
Sbjct: 805 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS---LAQQISDVVKQP 861
Query: 469 EVIATCGVALWLLLLGTAVCIHRRRRARVHLGP---GLYRYTSE---DAI-------LKH 515
IA G A W++L+ ++ ++R R+ R L G+ + T + +A+ L +
Sbjct: 862 AFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQRGGEAVSSGGRPGLLN 921
Query: 516 RMDHSDSQWLADTWRSTSGSR-DLSSSSSLSSRLGADARDPLDCRRSLLSWDSRSPGVPL 574
+ + WLADTW +T + D S S + +D+ L+ SR PG P
Sbjct: 922 ISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSN---------LTTYSR-PGQPT 971
Query: 575 -LPDTSTFYGSLIAELPSSTPARPSPQVPAVRRLPPQLAQLSSPCSSSDSLCSRRGLSSP 633
T +L + + + + + ++A + + L +
Sbjct: 972 PYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRAND- 1030
Query: 634 RLSLAPAEAWKAKKKQELQHA-NSSPLLRGSHSLELRACELGNRGSKNLSQSPGAVPQAL 692
++ P + Q + NSS RGS + G++G K +++P Q
Sbjct: 1031 --TVPPTIPYNQSYDQNTGGSYNSSD--RGSSTS-------GSQGHKKGARTPKVPKQGG 1079
Query: 693 VAWRALGPKLLSSSNELVTRHLPPAPLFPHETPPTQSQQTQPPVAPQAPSSILLPAAPIP 752
+ W L LPP P H P + S++ V + P P
Sbjct: 1080 MNWADL---------------LPPPPA--HPPPHSNSEEYNISVDESYDQEMPCPVPPAR 1122
Query: 753 ILSPCSPPSPQASSLSGPSPASSRLSSSSLSSLGEDQDSVLTP---EEVALCLE------ 803
+ + P SS + S + LTP EE+ L+
Sbjct: 1123 MYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEET 1182
Query: 804 --LSEGEETPRNSVSPMP--RAPSPPTTYGYISVPTASEF-TDMGRTGGGVGPKGGVLLC 858
+ + R VSP P R SPP TYGYIS P S+ TD +
Sbjct: 1183 GHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQ 1242
Query: 859 PPRPCL-----TPTPS--------EGSLANGWGSASEDNAASARASLVSSSDGSFLADAH 905
R L TP S GS+ NGWGSASE++ S+ S VSSSDGSF DA
Sbjct: 1243 TRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDAD 1302
Query: 906 FARALAVAVDSFGFGLEPRE----ADCVFIDASSPPSPRDEIFLTPNLSLPLWE-WRPDW 960
FA+A+A A + G + R+ A AS P P + N+S + + RP
Sbjct: 1303 FAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAK 1362
Query: 961 LEDMEVSHTQR--LGRGMPPWP-PDSQISSQRSQ 991
+ H +R +PP P P I S +Q
Sbjct: 1363 KLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQ 1396
Score = 176 bits (446), Expect = 1e-43
Identities = 92/218 (42%), Positives = 123/218 (56%), Gaps = 9/218 (4%)
Query: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
+D PP+I+ HP D + PA ++C+A G+P PTI W G+ + DP LLP
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
G+L L+ G+ D GVY C A N LG AVS A L VA+LR+DF+ P
Sbjct: 85 SGSLFFLR------IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
D++ VGE +EC PP GHPEPT+SW KDG PL + R T+ GG L++ KSD G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRI 242
Y+CV TN G RES A +++ E + + LAV +
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Score = 80.5 bits (197), Expect = 7e-15
Identities = 103/425 (24%), Positives = 160/425 (37%), Gaps = 59/425 (13%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P + P + A C+A G P PT+RW + L P + + D TL +
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIR 279
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRE--DFQIQPRDMVAV 149
+ A D+G YTC A N +G A A L+V V E F ++PRD V
Sbjct: 280 KVTA-----------GDMGSYTCVAENMVGKA-EASATLTVQVGSEPPHFVVKPRDQVVA 327
Query: 150 VGEQFTLECGPPWGHPEPTVSWWKDGKP---LALQP----GRHTVS-GGSLLMARAEKSD 201
+G T +C G+P+P + W ++G + QP R +VS G L + ++SD
Sbjct: 328 LGRTVTFQC-EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 386
Query: 202 EGTYMCVATNSAGHRESRAARVSIQEPQDYTEPV---ELLAVRIQLENVTLLNPDPAEGP 258
G Y+C N AG ++A D PV + + ++ +L+ P
Sbjct: 387 VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSP 446
Query: 259 KPRPAVWLSWKVSGPAAPAQS------YTALFRTQTAPGGQGAPWAEELLAGWQSAELGG 312
P + W+ G Q + + + A G + +A S E
Sbjct: 447 VPT----ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT--CIASTPSGEATW 500
Query: 313 LHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPA 372
+ + EF V R P+ +PSAP + TV +SW P
Sbjct: 501 SAYIEVQEFGVPVQPPRPTDPN----------LIPSAPSKPEVTDVSRNTVTLSW--QPN 548
Query: 373 ENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE---IATHMPGS-YCVQVAAVTGAGA 428
N Y + + + S ++W V E + E I P + Y V A G
Sbjct: 549 LNSGATPTSYIIEAFSHAS--GSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGI 606
Query: 429 GEPSR 433
+PS+
Sbjct: 607 SDPSQ 611
Score = 69.3 bits (168), Expect = 2e-11
Identities = 65/227 (28%), Positives = 90/227 (39%), Gaps = 25/227 (11%)
Query: 37 HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95
+P D + PA M CQ G P PTI W +G PL D + G L++
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD--DKDERITIRGGKLMITY--- 190
Query: 96 RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155
+D G Y C +N +G S A L+V + R F +P ++ V +
Sbjct: 191 --------TRKSDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAE 241
Query: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMAR-AEKSDEGTYMCVATNSAG 214
+C G P PTV W KD L R+ + L R D G+Y CVA N G
Sbjct: 242 FKCEAR-GDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 215 HRESRA---ARVSIQEPQDYTEP---VELLAVRIQLENVTLLNPDPA 255
E+ A +V + P +P V L + + NP PA
Sbjct: 299 KAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 345
Score = 68.2 bits (165), Expect = 4e-11
Identities = 81/320 (25%), Positives = 121/320 (37%), Gaps = 54/320 (16%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP +V P+DQ+ C+A+G P P I W G L
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS--------------QNLLFS 359
Query: 91 LQPP---------ARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED--- 138
QPP G +D+G Y C+ N G+ +++ A L V + D
Sbjct: 360 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK-AYLEVTDVIADRPP 418
Query: 139 --FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMA 195
+ P + V F L C G P PT+ W KDG ++ Q R + G L +
Sbjct: 419 PVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477
Query: 196 RAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPA 255
A+ D G Y C+A+ +G + +A + +QE V +Q T N P+
Sbjct: 478 YAKLGDTGRYTCIASTPSG-EATWSAYIEVQE----------FGVPVQPPRPTDPNLIPS 526
Query: 256 EGPKP------RPAVWLSWK--VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQS 307
KP R V LSW+ ++ A P F A G AE + ++
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF--SHASGSSWQTVAENVKT--ET 582
Query: 308 AELGGLHWGQDYEFKVRPSS 327
+ + GL Y F VR ++
Sbjct: 583 SAIKGLKPNAIYLFLVRAAN 602
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 182 bits (461), Expect = 2e-45
Identities = 150/409 (36%), Positives = 186/409 (45%), Gaps = 46/409 (11%)
Query: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
+D+ P+I+ P D L PA + C+A G+P P I W NG ++ V DP LLP
Sbjct: 60 EDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLP 119
Query: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
G L P H G+ D GVYTC A N LG A SR A L VAVLR+DF+ P
Sbjct: 120 SGALFF---PRIVH---GRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG 173
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
++V VGE LEC PP GHPEP+VSW KDG L + GR T+ GG L+M+ KSD G
Sbjct: 174 NVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGM 233
Query: 205 YMCVATNSAGHRESRAARVSIQE-PQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Y+CVA+N AG RES AA V + E P PV V + VT L + P PR
Sbjct: 234 YVCVASNMAGERESAAAEVMVLERPSFLRRPVN--QVVLADAPVTFLCEVKGD-PPPR-- 288
Query: 264 VWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKV 323
L W+ P Y R+ L G SAE G Y
Sbjct: 289 --LRWRKEDGELPTGRYE--IRSD-----------HSLWIGHVSAEDEG-----TYTCVA 328
Query: 324 RPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVF---VSWVPPPAENHNGIIR 380
S GRA S L + +P ++ + PQ+ PG F PPPA
Sbjct: 329 ENSVGRAEA--SGSLSVHVPPQLVT-QPQDQMAAPGESVAFQCETKGNPPPAIFWQK--E 383
Query: 381 GYQVWSLGNTSLPPANWTVVGEQTQLEIATHMPGS---YCVQVAAVTGA 426
G QV + SL P V + QL I G Y Q +V G+
Sbjct: 384 GSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGS 432
Score = 152 bits (383), Expect = 2e-36
Identities = 233/964 (24%), Positives = 337/964 (34%), Gaps = 126/964 (13%)
Query: 19 LLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPD 78
LL I G PP IL P +Q + C+ +G P P++RW +GQ L
Sbjct: 438 LLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQ----- 492
Query: 79 PHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED 138
G L + A G + D+G Y+C A + G A G +RED
Sbjct: 493 -------GDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWSGW----LKMRED 541
Query: 139 FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW-WKDGKPLALQPGRHTVSGGSLLMARA 197
+ + P + T PP +P V+ K+ L +P T + + + A
Sbjct: 542 WGVSP--------DPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIEA 593
Query: 198 EKSDEG-TYMCVA------TNSAGHRESRAARV---------SIQEPQDYTEPVE----- 236
G T+ VA T++ + + + EP +EPV
Sbjct: 594 FSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDSS 653
Query: 237 --------------LLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTA 282
L V ++L+ +L P + +SW V GP Q +
Sbjct: 654 PSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQ---------VSWTVDGPVQLVQGFRV 704
Query: 283 LFRTQTAPGGQGAPWAEELLAG--WQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLL 340
+R G +G W L QS L GL G + KV+ G +S +
Sbjct: 705 SWRVA---GPEGGSWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTR 761
Query: 341 RLPEKVPSAPPQEVTLK---PGNGTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANW 397
+PE+ PS PPQ V + GN ++ VSW PP NG+I YQ+W LGN S N
Sbjct: 762 SIPEEAPSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNR 821
Query: 398 TVVGEQTQLEIATHMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPS-EHGP 455
+ G + +PG Y VAA T AG G PS PV L Q EP E G
Sbjct: 822 SAAGWARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPV---LVQLPSPPDLEPGLEVGA 878
Query: 456 WTLEQLRATLKRPEVIATCGVALWLLLLGTAVCIHRRRRARVHLGPGLYRYTSEDAILKH 515
+L L+ P +A G A LLLG ++ RR+ R L + A+
Sbjct: 879 GLAVRLARVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAV--- 935
Query: 516 RMDHSDS-----------------QWLADTW--RSTSGSRDLSSSSSLSSRLGADARDPL 556
HS+ WLAD+W S S S S S D R
Sbjct: 936 SFPHSEGLSGASSRPPMGLGPAPYSWLADSWPHPSRSPSAQEPRGSCCPSNPDPDDRYYN 995
Query: 557 DCRRSL-LSWDSR---SPGVPLLPDTSTFYGSLIAELPSSTPARPSPQV-PAVRRLPPQL 611
+ SL L+ +R +PG + T G + P PS + P + PP+
Sbjct: 996 EAGISLYLAQTARGTAAPGEGPVYSTIDPAGEELQTFHGGFPQHPSGDLGPWSQYAPPEW 1055
Query: 612 AQLSSPCSSSDSLCSRRGLSSPRLSLAPAEAWKAKKKQELQHANSSPLLRGSHSLELRAC 671
+Q S + + P L+ A + L GS E
Sbjct: 1056 SQGDSGAKGGKVKLLGKPVQMPSLNWPEALPPPPPSCELSCLEGPEEELEGSSEPEEWCP 1115
Query: 672 ELGNRGSKNLSQSPGA--VPQALVAWRALGPKLLSSSNELVTRHLPPAPLFPHETPPTQS 729
+ R S G V + + P S +T P P P + P
Sbjct: 1116 PMPERSHLTEPSSSGGCLVTPSRRETPSPTPSYGQQSTATLTPSPPDPPQPPTDMPHLHQ 1175
Query: 730 QQTQPPVAPQAPSSILLPAAPIPILSPCS-PPSPQASSLSGPSPASSRLSSSSLSSLGED 788
+ P+ P +P S+ P I P P AS PSPA S +SS+ +
Sbjct: 1176 MPRRVPLGPSSPLSVSQPMLGIREARPAGLGAGPAASPHLSPSPAPS-TASSAPGRTWQG 1234
Query: 789 QDSVLTPEEVALCLELSEGEETP---RNSVSPMPRAPSPP---TTYGYISVPTASEFTDM 842
+ P + + + P NS +P P PP + + A + +
Sbjct: 1235 NGEMTPPLQGPRARFRKKPKALPYRRENSPGDLPPPPLPPPEEEASWALELRAAGSMSSL 1294
Query: 843 GRTGGG-------VGPKGGVLLCPPRPCLTPTPSEGSLANGWGSASEDNAASARASLVSS 895
R G V +L P P L+ G G+++ A S + SS
Sbjct: 1295 ERERSGERKAVQAVPLAAQRVLHPDEEAWLPYSRPSFLSRGQGTSTCSTAGSNSSRGSSS 1354
Query: 896 SDGS 899
S GS
Sbjct: 1355 SRGS 1358
Score = 94.0 bits (232), Expect = 6e-19
Identities = 124/472 (26%), Positives = 183/472 (38%), Gaps = 80/472 (16%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P L P +Q+ P C+ G PPP +RW L P + + D +L +
Sbjct: 258 PSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGEL---PTGRYEIRSDHSLWI- 313
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVG 151
G + D G YTC A N +G A + G+ LSV V + QP+D +A G
Sbjct: 314 ----------GHVSAEDEGTYTCVAENSVGRAEASGS-LSVHVPPQ-LVTQPQDQMAAPG 361
Query: 152 EQFTLECGPPWGHPEPTVSWWKDGKPLALQP-------GRHTVSG-GSLLMARAEKSDEG 203
E +C G+P P + W K+G + L P GR +VS G L + ++ D G
Sbjct: 362 ESVAFQCETK-GNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAG 420
Query: 204 TYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Y+C A + AG ++A D PV L N TL+ +
Sbjct: 421 YYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPA----NQTLVLGS---------S 467
Query: 264 VWLSWKVSGPAAPA----------QSYTALFRTQTAPGGQGAPWAEELLAGWQS----AE 309
VWL +V+G P+ Q F+T A G +E+ G+ S +
Sbjct: 468 VWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTM-ANGTLYIANVQEMDMGFYSCVAKSS 526
Query: 310 LGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVP 369
G W K+R G + P + P P AP Q V + ++ ++W P
Sbjct: 527 TGEATWSG--WLKMREDWGVSPDPPTE------PSSPPGAPSQPVVTEITKNSITLTWKP 578
Query: 370 PPAENHNGIIRGYQVWSLGNTSLPPA---NWTVVGEQTQLE---IATHMPGS-YCVQVAA 422
P G V S + PA W V + QLE ++ P + Y V A
Sbjct: 579 NPQ-------TGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRA 631
Query: 423 VTGAGAGEP---SRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRPEVI 471
V G EP S PV + + R ++P G L ++ L+ P V+
Sbjct: 632 VGAWGLSEPSPVSEPV-RTQDSSPSRPVEDP-WRGQQGLAEVAVRLQEPIVL 681
Score = 79.0 bits (193), Expect = 2e-14
Identities = 56/196 (28%), Positives = 87/196 (44%), Gaps = 11/196 (5%)
Query: 24 GGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLL 83
G ++ PPQ++ PQDQ+ C+ G PPP I W G + + P L
Sbjct: 339 GSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFP--SQSLQ 396
Query: 84 PDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRG----ARLSVAVLREDF 139
P G + RG + D G Y C+A + G+ +++ S+ L
Sbjct: 397 PTGRFSV---SPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVI 453
Query: 140 QIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMARAE 198
P + V+G L C G+P+P+V W KDG+ L + T++ G+L +A +
Sbjct: 454 LQGPANQTLVLGSSVWLPCRVT-GNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQ 512
Query: 199 KSDEGTYMCVATNSAG 214
+ D G Y CVA +S G
Sbjct: 513 EMDMGFYSCVAKSSTG 528
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 176 bits (446), Expect = 1e-43
Identities = 92/218 (42%), Positives = 123/218 (56%), Gaps = 9/218 (4%)
Query: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
+D PP+I+ HP D + PA ++C+A G+P PTI W G+ + DP LLP
Sbjct: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
Query: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
G+L L+ G+ D GVY C A N LG AVS A L VA+LR+DF+ P
Sbjct: 85 SGSLFFLR------IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
D++ VGE +EC PP GHPEPT+SW KDG PL + R T+ GG L++ KSD G
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
Query: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRI 242
Y+CV TN G RES A +++ E + + LAV +
Sbjct: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Score = 135 bits (341), Expect = 1e-31
Identities = 153/583 (26%), Positives = 231/583 (39%), Gaps = 90/583 (15%)
Query: 26 MAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85
+A PP I P +Q G +SC A+G P PTI W +G +S D
Sbjct: 413 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST---------QD 463
Query: 86 GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQI---- 141
+ L+ G A D G YTC AS G A S + ++F +
Sbjct: 464 SRIKQLE---NGVLQIRYAKLGDTGRYTCIASTPSGEAT-----WSAYIEVQEFGVPVQP 515
Query: 142 -QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLA------LQPGRHTVSGGSLLM 194
+P D + E T+SW + A ++ H +
Sbjct: 516 PRPTDPNLIPSAPSKPEVTDV-SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 574
Query: 195 ARAEKSDEGTYMCVATNSAGHRESRAARV-SIQEPQDYTEPV------------------ 235
A K++ + N+ RAA I +P ++PV
Sbjct: 575 AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 634
Query: 236 -ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQG 294
EL + L N T+L+ E + W V + Q Y L+R A G+
Sbjct: 635 RELGNAVLHLHNPTVLSSSSIE---------VHWTVDQQSQYIQGYKILYRPSGANHGE- 684
Query: 295 APWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ 352
+ W E S + L G +YE K RP +G DS + + E+ PSAPPQ
Sbjct: 685 SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 744
Query: 353 EVTLKP--GNGT-VFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIA 409
VT+ GNGT + VSW PPP + NG+++ Y+VW LGN + N TV G + I
Sbjct: 745 GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 804
Query: 410 THMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468
+PG Y V+VAA TGAG+G S P + L+ + E +Q+ +K+P
Sbjct: 805 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS---LAQQISDVVKQP 861
Query: 469 EVIATCGVALWLLLLGTAVCIHRRRRARVHL---------------GPGLYRYTSEDAI- 512
IA G A W++L+ ++ ++R R+ R L P + +A+
Sbjct: 862 AFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVS 921
Query: 513 ------LKHRMDHSDSQWLADTWRSTSGSRDLSSSSSLSSRLG 549
L + + + WLADTW +T + + S S ++ G
Sbjct: 922 SGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNG 964
Score = 80.5 bits (197), Expect = 7e-15
Identities = 103/425 (24%), Positives = 160/425 (37%), Gaps = 59/425 (13%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P + P + A C+A G P PT+RW + L P + + D TL +
Sbjct: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIR 279
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRE--DFQIQPRDMVAV 149
+ A D+G YTC A N +G A A L+V V E F ++PRD V
Sbjct: 280 KVTA-----------GDMGSYTCVAENMVGKA-EASATLTVQVGSEPPHFVVKPRDQVVA 327
Query: 150 VGEQFTLECGPPWGHPEPTVSWWKDGKP---LALQP----GRHTVS-GGSLLMARAEKSD 201
+G T +C G+P+P + W ++G + QP R +VS G L + ++SD
Sbjct: 328 LGRTVTFQC-EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 386
Query: 202 EGTYMCVATNSAGHRESRAARVSIQEPQDYTEPV---ELLAVRIQLENVTLLNPDPAEGP 258
G Y+C N AG ++A D PV + + ++ +L+ P
Sbjct: 387 VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSP 446
Query: 259 KPRPAVWLSWKVSGPAAPAQS------YTALFRTQTAPGGQGAPWAEELLAGWQSAELGG 312
P + W+ G Q + + + A G + +A S E
Sbjct: 447 VPT----ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT--CIASTPSGEATW 500
Query: 313 LHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPA 372
+ + EF V R P+ +PSAP + TV +SW P
Sbjct: 501 SAYIEVQEFGVPVQPPRPTDPN----------LIPSAPSKPEVTDVSRNTVTLSW--QPN 548
Query: 373 ENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE---IATHMPGS-YCVQVAAVTGAGA 428
N Y + + + S ++W V E + E I P + Y V A G
Sbjct: 549 LNSGATPTSYIIEAFSHAS--GSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGI 606
Query: 429 GEPSR 433
+PS+
Sbjct: 607 SDPSQ 611
Score = 80.5 bits (197), Expect = 7e-15
Identities = 98/353 (27%), Positives = 134/353 (37%), Gaps = 52/353 (14%)
Query: 674 GNRGSKNLSQSPGAVPQALVAWRALGPKLLSSSNELVTRHLPPAPLFPHETPPTQSQQTQ 733
G++G K +++P Q + W L LPP P H P + S++
Sbjct: 1072 GSQGHKKGARTPKVPKQGGMNWADL---------------LPPPPA--HPPPHSNSEEYN 1114
Query: 734 PPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSSSLSSLGEDQDSVL 793
V + P P + P SS + S + L
Sbjct: 1115 ISVDESYDQEMPCPVPPARTYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTATL 1174
Query: 794 TP---EEVALCLE--------LSEGEETPRNSVSPMP--RAPSPPTTYGYISVPTASEF- 839
TP EE+ L+ + + R VSP P R SPP TYGYIS P S+
Sbjct: 1175 TPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMD 1234
Query: 840 TDMGRTGGGVGPKGGVLLCPPRPCL-----TPTPS--------EGSLANGWGSASEDNAA 886
TD + R L TP S GS+ NGWGSASE++
Sbjct: 1235 TDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNI 1294
Query: 887 SARASLVSSSDGSFLADAHFARALAVAVDSFGFGLEPRE----ADCVFIDASSPPSPRDE 942
S+ S VSSSDGSF DA FA+A+A A + G + R+ A AS P P
Sbjct: 1295 SSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSP 1354
Query: 943 IFLTPNLSLPLWE-WRPDWLEDMEVSHTQR--LGRGMPPWP-PDSQISSQRSQ 991
+ N+S + + RP + H +R +PP P P I S +Q
Sbjct: 1355 VSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQ 1407
Score = 69.3 bits (168), Expect = 2e-11
Identities = 65/227 (28%), Positives = 90/227 (39%), Gaps = 25/227 (11%)
Query: 37 HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95
+P D + PA M CQ G P PTI W +G PL D + G L++
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD--DKDERITIRGGKLMITY--- 190
Query: 96 RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155
+D G Y C +N +G S A L+V + R F +P ++ V +
Sbjct: 191 --------TRKSDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAE 241
Query: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMAR-AEKSDEGTYMCVATNSAG 214
+C G P PTV W KD L R+ + L R D G+Y CVA N G
Sbjct: 242 FKCEAR-GDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
Query: 215 HRESRA---ARVSIQEPQDYTEP---VELLAVRIQLENVTLLNPDPA 255
E+ A +V + P +P V L + + NP PA
Sbjct: 299 KAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 345
Score = 68.2 bits (165), Expect = 4e-11
Identities = 81/320 (25%), Positives = 121/320 (37%), Gaps = 54/320 (16%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP +V P+DQ+ C+A+G P P I W G L
Sbjct: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS--------------QNLLFS 359
Query: 91 LQPP---------ARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED--- 138
QPP G +D+G Y C+ N G+ +++ A L V + D
Sbjct: 360 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK-AYLEVTDVIADRPP 418
Query: 139 --FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMA 195
+ P + V F L C G P PT+ W KDG ++ Q R + G L +
Sbjct: 419 PVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477
Query: 196 RAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPA 255
A+ D G Y C+A+ +G + +A + +QE V +Q T N P+
Sbjct: 478 YAKLGDTGRYTCIASTPSG-EATWSAYIEVQE----------FGVPVQPPRPTDPNLIPS 526
Query: 256 EGPKP------RPAVWLSWK--VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQS 307
KP R V LSW+ ++ A P F A G AE + ++
Sbjct: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF--SHASGSSWQTVAENVKT--ET 582
Query: 308 AELGGLHWGQDYEFKVRPSS 327
+ + GL Y F VR ++
Sbjct: 583 SAIKGLKPNAIYLFLVRAAN 602
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 157 bits (397), Expect = 5e-38
Identities = 94/257 (36%), Positives = 131/257 (50%), Gaps = 17/257 (6%)
Query: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
+D PP+I+ HP D + P ++C+A G+P PTI W +G+ + DP LLP
Sbjct: 43 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 102
Query: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
G+L L+ G+ D G Y C A N LG AVSR A L VA+LR+DF+ P
Sbjct: 103 SGSLFFLR------IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 156
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
D+V GE LEC PP GHPEPT+ W KD + + R ++ GG L+++ KSD G
Sbjct: 157 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 216
Query: 205 YMCVATNSAGHRESRAARVSI-QEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Y CV TN G R+S A +++ + P P+ ++ LE + +G P+P
Sbjct: 217 YTCVGTNMVGERDSDPAELTVFERPTFLRRPIN----QVVLEEEAVEFRCQVQG-DPQPT 271
Query: 264 VWLSWKVSGPAAPAQSY 280
V WK P Y
Sbjct: 272 V--RWKKDDADLPRGRY 286
Score = 143 bits (361), Expect = 7e-34
Identities = 153/555 (27%), Positives = 234/555 (42%), Gaps = 91/555 (16%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP IL P +Q G A + C+A+G P P I WL G + DP + + L
Sbjct: 433 PPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG--FTFPGRDPRATIQEQGTLQ 490
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVV 150
++ +D G YTC A++ G S A L V + A +
Sbjct: 491 IK----------NLRISDTGTYTCVATSSSGET-SWSAVLDVT-----------ESGATI 528
Query: 151 GEQFTLEC--GPPWGHPEPTVSWWKDGKPLALQPGRH-TVSGGSLLMARAEKSDEGTYMC 207
+ + L GPP P+ T K+ L+ QPG T+ + ++ +S ++
Sbjct: 529 SKNYDLSDLPGPP-SKPQVT-DVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQT 586
Query: 208 VATNSA-------GHRES-------RAARVS-IQEPQDYTEPV----------------- 235
VA + G R + RA + +P ++PV
Sbjct: 587 VANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQV 646
Query: 236 --ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQ 293
EL V ++L N +L P V ++W V Q Y ++R QT+
Sbjct: 647 QKELGDVLVRLHNPVVLTPT---------TVQVTWTVDRQPQFIQGYRVMYR-QTSGLQA 696
Query: 294 GAPWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPP 351
+ W + + +SA L L G YE KVRP +G DS +R E+ PSAPP
Sbjct: 697 TSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPP 756
Query: 352 QEVTL----KPGNGTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE 407
Q VT+ + ++ VSW PPP ++ NGII+ Y++W LGN + N TV +
Sbjct: 757 QSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVI 816
Query: 408 IATHMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLK 466
I PG Y V+VAA T AG G S P +++ + E +E+ EQ+ +K
Sbjct: 817 IGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVI---TENNNSITEQITDVVK 873
Query: 467 RPEVIATCGVALWLLLLGTAVCIHRRRRARVHLGPGLYRYTSEDAILKHR------MDHS 520
+P IA G A W++L+G ++ ++ RR+ R L + D L ++
Sbjct: 874 QPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAG 933
Query: 521 DSQ--WLADTWRSTS 533
D WLAD+W +TS
Sbjct: 934 DPSYPWLADSWPATS 948
Score = 74.7 bits (182), Expect = 4e-13
Identities = 68/238 (28%), Positives = 102/238 (42%), Gaps = 26/238 (10%)
Query: 37 HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95
+P D + PA + CQ G P PTI W + + + + G L++
Sbjct: 154 NPTDVVVAAGEPAILECQPPRGHPEPTIYW--KKDKVRIDDKEERISIRGGKLMI----- 206
Query: 96 RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155
+D G+YTC +N +G S A L+V R F +P + V + E
Sbjct: 207 ------SNTRKSDAGMYTCVGTNMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVE 259
Query: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGG-SLLMARAEKSDEGTYMCVATNSAG 214
C G P+PTV W KD L GR+ + +L + + +DEGTYMC+A N G
Sbjct: 260 FRCQVQ-GDPQPTVRWKKDDADLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 316
Query: 215 HRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSG 272
E+ A PQ P + +I + T+ P +G P+PAV+ W+ G
Sbjct: 317 KMEASATLTVRAPPQFVVRPRD----QIVAQGRTVTFPCETKG-NPQPAVF--WQKEG 367
Score = 74.7 bits (182), Expect = 4e-13
Identities = 70/268 (26%), Positives = 106/268 (39%), Gaps = 41/268 (15%)
Query: 30 SPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH------LL 83
+PPQ +V P+DQ+ C+ G P P + W G + P P +
Sbjct: 328 APPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVS 387
Query: 84 PDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED----- 138
P G L + +D G Y C+A G+ +++ A+L V + D
Sbjct: 388 PTGDLTIT-----------NIQRSDAGYYICQALTVAGSILAK-AQLEVTDVLTDRPPPI 435
Query: 139 FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTV-SGGSLLMARA 197
P + V L+C G P P +SW K+G + R T+ G+L +
Sbjct: 436 ILQGPANQTLAVDGTALLKC-KATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNL 494
Query: 198 EKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEG 257
SD GTY CVAT+S+G A D TE ++ L ++ P P
Sbjct: 495 RISDTGTYTCVATSSSGETSWSAV-------LDVTESGATISKNYDLSDL----PGPPSK 543
Query: 258 PK----PRPAVWLSWKVSGPAA-PAQSY 280
P+ + +V LSW+ P PA +Y
Sbjct: 544 PQVTDVTKNSVTLSWQPGTPGTLPASAY 571
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 157 bits (397), Expect = 5e-38
Identities = 94/257 (36%), Positives = 131/257 (50%), Gaps = 17/257 (6%)
Query: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
+D PP+I+ HP D + P ++C+A G+P PTI W +G+ + DP LLP
Sbjct: 27 EDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLP 86
Query: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
G+L L+ G+ D G Y C A N LG AVSR A L VA+LR+DF+ P
Sbjct: 87 SGSLFFLR------IVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
D+V GE LEC PP GHPEPT+ W KD + + R ++ GG L+++ KSD G
Sbjct: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
Query: 205 YMCVATNSAGHRESRAARVSI-QEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Y CV TN G R+S A +++ + P P+ ++ LE + +G P+P
Sbjct: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPIN----QVVLEEEAVEFRCQVQG-DPQPT 255
Query: 264 VWLSWKVSGPAAPAQSY 280
V WK P Y
Sbjct: 256 V--RWKKDDADLPRGRY 270
Score = 143 bits (361), Expect = 7e-34
Identities = 153/555 (27%), Positives = 234/555 (42%), Gaps = 91/555 (16%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP IL P +Q G A + C+A+G P P I WL G + DP + + L
Sbjct: 417 PPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEG--FTFPGRDPRATIQEQGTLQ 474
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVV 150
++ +D G YTC A++ G S A L V + A +
Sbjct: 475 IK----------NLRISDTGTYTCVATSSSGET-SWSAVLDVT-----------ESGATI 512
Query: 151 GEQFTLEC--GPPWGHPEPTVSWWKDGKPLALQPGRH-TVSGGSLLMARAEKSDEGTYMC 207
+ + L GPP P+ T K+ L+ QPG T+ + ++ +S ++
Sbjct: 513 SKNYDLSDLPGPP-SKPQVT-DVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQT 570
Query: 208 VATNSA-------GHRES-------RAARVS-IQEPQDYTEPV----------------- 235
VA + G R + RA + +P ++PV
Sbjct: 571 VANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQV 630
Query: 236 --ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQ 293
EL V ++L N +L P V ++W V Q Y ++R QT+
Sbjct: 631 QKELGDVLVRLHNPVVLTPT---------TVQVTWTVDRQPQFIQGYRVMYR-QTSGLQA 680
Query: 294 GAPWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPP 351
+ W + + +SA L L G YE KVRP +G DS +R E+ PSAPP
Sbjct: 681 TSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPP 740
Query: 352 QEVTL----KPGNGTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE 407
Q VT+ + ++ VSW PPP ++ NGII+ Y++W LGN + N TV +
Sbjct: 741 QSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVI 800
Query: 408 IATHMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLK 466
I PG Y V+VAA T AG G S P +++ + E +E+ EQ+ +K
Sbjct: 801 IGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVI---TENNNSITEQITDVVK 857
Query: 467 RPEVIATCGVALWLLLLGTAVCIHRRRRARVHLGPGLYRYTSEDAILKHR------MDHS 520
+P IA G A W++L+G ++ ++ RR+ R L + D L ++
Sbjct: 858 QPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAG 917
Query: 521 DSQ--WLADTWRSTS 533
D WLAD+W +TS
Sbjct: 918 DPSYPWLADSWPATS 932
Score = 74.7 bits (182), Expect = 4e-13
Identities = 68/238 (28%), Positives = 102/238 (42%), Gaps = 26/238 (10%)
Query: 37 HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95
+P D + PA + CQ G P PTI W + + + + G L++
Sbjct: 138 NPTDVVVAAGEPAILECQPPRGHPEPTIYW--KKDKVRIDDKEERISIRGGKLMI----- 190
Query: 96 RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155
+D G+YTC +N +G S A L+V R F +P + V + E
Sbjct: 191 ------SNTRKSDAGMYTCVGTNMVGERDSDPAELTVFE-RPTFLRRPINQVVLEEEAVE 243
Query: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGG-SLLMARAEKSDEGTYMCVATNSAG 214
C G P+PTV W KD L GR+ + +L + + +DEGTYMC+A N G
Sbjct: 244 FRCQVQ-GDPQPTVRWKKDDADLPR--GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVG 300
Query: 215 HRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSG 272
E+ A PQ P + +I + T+ P +G P+PAV+ W+ G
Sbjct: 301 KMEASATLTVRAPPQFVVRPRD----QIVAQGRTVTFPCETKG-NPQPAVF--WQKEG 351
Score = 74.7 bits (182), Expect = 4e-13
Identities = 70/268 (26%), Positives = 106/268 (39%), Gaps = 41/268 (15%)
Query: 30 SPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH------LL 83
+PPQ +V P+DQ+ C+ G P P + W G + P P +
Sbjct: 312 APPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVS 371
Query: 84 PDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED----- 138
P G L + +D G Y C+A G+ +++ A+L V + D
Sbjct: 372 PTGDLTIT-----------NIQRSDAGYYICQALTVAGSILAK-AQLEVTDVLTDRPPPI 419
Query: 139 FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTV-SGGSLLMARA 197
P + V L+C G P P +SW K+G + R T+ G+L +
Sbjct: 420 ILQGPANQTLAVDGTALLKC-KATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNL 478
Query: 198 EKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEG 257
SD GTY CVAT+S+G A D TE ++ L ++ P P
Sbjct: 479 RISDTGTYTCVATSSSGETSWSAV-------LDVTESGATISKNYDLSDL----PGPPSK 527
Query: 258 PK----PRPAVWLSWKVSGPAA-PAQSY 280
P+ + +V LSW+ P PA +Y
Sbjct: 528 PQVTDVTKNSVTLSWQPGTPGTLPASAY 555
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 115 bits (289), Expect = 2e-25
Identities = 117/418 (27%), Positives = 173/418 (41%), Gaps = 47/418 (11%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P I + PQ ++ + A M C A G P P I W + +P DP +G + L
Sbjct: 135 PSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKD-----FLPVDP--ATSNGRIKQL 187
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLR--EDFQIQPRDMVAV 149
+ G + +D G Y C A+N GT S A L V V R F I P +
Sbjct: 188 RS---GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVM 244
Query: 150 VGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVA 209
G L C G P P V W + L + V L ++ +S Y CVA
Sbjct: 245 PGGSVNLTCVAV-GAPMPYVKWMMGAEELTKED-EMPVGRNVLELSNVVRS--ANYTCVA 300
Query: 210 TNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWK 269
+S G E+ A P+ P++L+ +VTL +W
Sbjct: 301 ISSLGMIEATAQVTVKALPKP---PIDLVVTETTATSVTL-----------------TWD 340
Query: 270 VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKVRPSSGR 329
SG + P Y +R A G +G P+ E +GGL +Y F+V +
Sbjct: 341 -SGNSEPVTYYGIQYR---AAGTEG-PFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSI 395
Query: 330 ARGPDSNVLLLRLPEKVPSAPPQEVTLKP-GNGTVFVSWVPPPAENHNGIIRGYQVWSLG 388
RGP S + R E+ PS+PP+ V + T+ V W PP E NG++RGY+V+
Sbjct: 396 GRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP--EEPNGLVRGYRVYYTP 453
Query: 389 NTSLPPANWTVVGEQTQL--EIATHMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAM 443
++ PP W L + + +PG +Y ++V A T G G PS + + +Q +
Sbjct: 454 DSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV 511
Score = 95.1 bits (235), Expect = 3e-19
Identities = 76/233 (32%), Positives = 115/233 (49%), Gaps = 31/233 (13%)
Query: 11 GRGSLPLLLLLIMGGMAQ----DSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWL 66
GR +PL+ L+M G+ DS P + P+DQ G A CQA+G+P P I W+
Sbjct: 8 GRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWM 67
Query: 67 LNGQPLSMVPPDPHHLLPD-GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVS 125
G+ +S + G++L +QP + D +Y C A+N LG ++
Sbjct: 68 KKGKKVSSQRFEVIEFDDGAGSVLRIQP---------LRVQRDEAIYECTATNSLG-EIN 117
Query: 126 RGARLSVAVLREDFQIQPRDMVAVVGEQF---------TLECGPPWGHPEPTVSWWKDGK 176
A+LSV E+ Q+ P +G Q T+ C G+P+P +SW+KD
Sbjct: 118 TSAKLSVL---EEEQLPPGFPSIDMGPQLKVVEKARTATMLCA-AGGNPDPEISWFKDFL 173
Query: 177 PL--ALQPGR-HTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQ 226
P+ A GR + G+L + +E+SD+G Y CVATNSAG R S A + ++
Sbjct: 174 PVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR 226
Score = 61.6 bits (148), Expect = 4e-09
Identities = 61/201 (30%), Positives = 83/201 (41%), Gaps = 36/201 (17%)
Query: 307 SAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGT-VFV 365
S +L GL +Y VR + GP+S+ +L+R E VPS PP++V ++P N T V V
Sbjct: 668 SWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHV 727
Query: 366 SWVPPPAENHNGIIRGYQVW-------------SLGNTSLPPANW-TVVGEQTQLEIATH 411
W P +G IRGYQV + + L A W E + I+
Sbjct: 728 YWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGL 787
Query: 412 MP-GSYCVQVAAVTGAGAGE-------------PSRPVCLLLEQAMERATQE-------P 450
P +Y V VAA T G G P RP ++ AM A + P
Sbjct: 788 TPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELP 847
Query: 451 SEHGPWTLEQLRATLKRPEVI 471
E + L+ RA RP I
Sbjct: 848 GELLGYRLQYCRADEARPNTI 868
Score = 58.9 bits (141), Expect = 2e-08
Identities = 43/136 (31%), Positives = 62/136 (45%), Gaps = 21/136 (15%)
Query: 319 YEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVT-LKPGNGTVFVSWVPPPAENHNG 377
Y F++ S G + + R + PSAPPQ+V + G+ TV VSWVPPPA++ NG
Sbjct: 578 YRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNG 637
Query: 378 IIRGYQV------------WSLGNTSLPPANWTVVGEQTQLEIATHMPGSYCVQVAAVTG 425
+I Y V + S ++W +VG + E Y V V A T
Sbjct: 638 VITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTE--------YRVWVRAHTD 689
Query: 426 AGAGEPSRPVCLLLEQ 441
G G S PV + ++
Sbjct: 690 VGPGPESSPVLVRTDE 705
Score = 40.4 bits (93), Expect = 0.008
Identities = 74/295 (25%), Positives = 111/295 (37%), Gaps = 43/295 (14%)
Query: 143 PRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTV-----SGGSLLMARA 197
P D + G + C G P+P ++W K GK ++ Q R V GS+L +
Sbjct: 39 PEDQTGLSGGVASFVCQAT-GEPKPRITWMKKGKKVSSQ--RFEVIEFDDGAGSVLRIQP 95
Query: 198 EK--SDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDP- 254
+ DE Y C ATNS G + +A++S+ E + + + QL+ V
Sbjct: 96 LRVQRDEAIYECTATNSLGEINT-SAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATM 154
Query: 255 --AEGPKPRPAVWLSW-KVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELG 311
A G P P + SW K P PA S + Q G +EE G
Sbjct: 155 LCAAGGNPDPEI--SWFKDFLPVDPATSNGRI--KQLRSGALQIESSEESDQG------- 203
Query: 312 GLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVP--SAPPQEVTLKPGNGTVFVSWVP 369
YE S+G +N L +R+ P S PP + PG G+V ++ V
Sbjct: 204 ------KYECVATNSAGTRYSAPAN-LYVRVRRVAPRFSIPPSSQEVMPG-GSVNLTCVA 255
Query: 370 PPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQT-QLEIATHMPGSYCVQVAAV 423
G Y W +G L + VG +L CV ++++
Sbjct: 256 V------GAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
Score = 33.9 bits (76), Expect = 0.79
Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 2/74 (2%)
Query: 312 GLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKP-GNGTVFVSWVPP 370
GLH G Y F++ + G + + R PE +PS PQ + + T ++W PP
Sbjct: 881 GLHKGTTYIFRLAAKNRAGLGEEFEKEI-RTPEDLPSGFPQNLHVTGLTTSTTELAWDPP 939
Query: 371 PAENHNGIIRGYQV 384
NG I Y V
Sbjct: 940 VLAERNGRIISYTV 953
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 115 bits (289), Expect = 2e-25
Identities = 117/418 (27%), Positives = 173/418 (41%), Gaps = 47/418 (11%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P I + PQ ++ + A M C A G P P I W + +P DP +G + L
Sbjct: 135 PSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKD-----FLPVDP--ATSNGRIKQL 187
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLR--EDFQIQPRDMVAV 149
+ G + +D G Y C A+N GT S A L V V R F I P +
Sbjct: 188 RS---GALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVM 244
Query: 150 VGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVA 209
G L C G P P V W + L + V L ++ +S Y CVA
Sbjct: 245 PGGSVNLTCVAV-GAPMPYVKWMMGAEELTKED-EMPVGRNVLELSNVVRS--ANYTCVA 300
Query: 210 TNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWK 269
+S G E+ A P+ P++L+ +VTL +W
Sbjct: 301 ISSLGMIEATAQVTVKALPKP---PIDLVVTETTATSVTL-----------------TWD 340
Query: 270 VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKVRPSSGR 329
SG + P Y +R A G +G P+ E +GGL +Y F+V +
Sbjct: 341 -SGNSEPVTYYGIQYR---AAGTEG-PFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSI 395
Query: 330 ARGPDSNVLLLRLPEKVPSAPPQEVTLKP-GNGTVFVSWVPPPAENHNGIIRGYQVWSLG 388
RGP S + R E+ PS+PP+ V + T+ V W PP E NG++RGY+V+
Sbjct: 396 GRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPP--EEPNGLVRGYRVYYTP 453
Query: 389 NTSLPPANWTVVGEQTQL--EIATHMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAM 443
++ PP W L + + +PG +Y ++V A T G G PS + + +Q +
Sbjct: 454 DSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGV 511
Score = 95.1 bits (235), Expect = 3e-19
Identities = 76/233 (32%), Positives = 115/233 (49%), Gaps = 31/233 (13%)
Query: 11 GRGSLPLLLLLIMGGMAQ----DSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWL 66
GR +PL+ L+M G+ DS P + P+DQ G A CQA+G+P P I W+
Sbjct: 8 GRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWM 67
Query: 67 LNGQPLSMVPPDPHHLLPD-GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVS 125
G+ +S + G++L +QP + D +Y C A+N LG ++
Sbjct: 68 KKGKKVSSQRFEVIEFDDGAGSVLRIQP---------LRVQRDEAIYECTATNSLG-EIN 117
Query: 126 RGARLSVAVLREDFQIQPRDMVAVVGEQF---------TLECGPPWGHPEPTVSWWKDGK 176
A+LSV E+ Q+ P +G Q T+ C G+P+P +SW+KD
Sbjct: 118 TSAKLSVL---EEEQLPPGFPSIDMGPQLKVVEKARTATMLCA-AGGNPDPEISWFKDFL 173
Query: 177 PL--ALQPGR-HTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQ 226
P+ A GR + G+L + +E+SD+G Y CVATNSAG R S A + ++
Sbjct: 174 PVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVR 226
Score = 65.5 bits (158), Expect = 2e-10
Identities = 62/192 (32%), Positives = 84/192 (43%), Gaps = 27/192 (14%)
Query: 307 SAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGT-VFV 365
S +L GL +Y VR + GP+S+ +L+R E VPS PP++V ++P N T V V
Sbjct: 668 SWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHV 727
Query: 366 SWVPPPAENHNGIIRGYQVW--SLGN---TSLPPANWTVVGEQTQLEIATHMP-GSYCVQ 419
W P +G IRGYQV L N LP ++ E + I+ P +Y V
Sbjct: 728 YWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVT 787
Query: 420 VAAVTGAGAGE-------------PSRPVCLLLEQAMERATQE-------PSEHGPWTLE 459
VAA T G G P RP ++ AM A + P E + L+
Sbjct: 788 VAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQ 847
Query: 460 QLRATLKRPEVI 471
RA RP I
Sbjct: 848 YCRADEARPNTI 859
Score = 58.9 bits (141), Expect = 2e-08
Identities = 43/136 (31%), Positives = 62/136 (45%), Gaps = 21/136 (15%)
Query: 319 YEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVT-LKPGNGTVFVSWVPPPAENHNG 377
Y F++ S G + + R + PSAPPQ+V + G+ TV VSWVPPPA++ NG
Sbjct: 578 YRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNG 637
Query: 378 IIRGYQV------------WSLGNTSLPPANWTVVGEQTQLEIATHMPGSYCVQVAAVTG 425
+I Y V + S ++W +VG + E Y V V A T
Sbjct: 638 VITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTE--------YRVWVRAHTD 689
Query: 426 AGAGEPSRPVCLLLEQ 441
G G S PV + ++
Sbjct: 690 VGPGPESSPVLVRTDE 705
Score = 40.4 bits (93), Expect = 0.008
Identities = 74/295 (25%), Positives = 111/295 (37%), Gaps = 43/295 (14%)
Query: 143 PRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTV-----SGGSLLMARA 197
P D + G + C G P+P ++W K GK ++ Q R V GS+L +
Sbjct: 39 PEDQTGLSGGVASFVCQAT-GEPKPRITWMKKGKKVSSQ--RFEVIEFDDGAGSVLRIQP 95
Query: 198 EK--SDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDP- 254
+ DE Y C ATNS G + +A++S+ E + + + QL+ V
Sbjct: 96 LRVQRDEAIYECTATNSLGEINT-SAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATM 154
Query: 255 --AEGPKPRPAVWLSW-KVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELG 311
A G P P + SW K P PA S + Q G +EE G
Sbjct: 155 LCAAGGNPDPEI--SWFKDFLPVDPATSNGRI--KQLRSGALQIESSEESDQG------- 203
Query: 312 GLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVP--SAPPQEVTLKPGNGTVFVSWVP 369
YE S+G +N L +R+ P S PP + PG G+V ++ V
Sbjct: 204 ------KYECVATNSAGTRYSAPAN-LYVRVRRVAPRFSIPPSSQEVMPG-GSVNLTCVA 255
Query: 370 PPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQT-QLEIATHMPGSYCVQVAAV 423
G Y W +G L + VG +L CV ++++
Sbjct: 256 V------GAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSL 304
Score = 33.9 bits (76), Expect = 0.79
Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 2/74 (2%)
Query: 312 GLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKP-GNGTVFVSWVPP 370
GLH G Y F++ + G + + R PE +PS PQ + + T ++W PP
Sbjct: 872 GLHKGTTYIFRLAAKNRAGLGEEFEKEI-RTPEDLPSGFPQNLHVTGLTTSTTELAWDPP 930
Query: 371 PAENHNGIIRGYQV 384
NG I Y V
Sbjct: 931 VLAERNGRIISYTV 944
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 103 bits (256), Expect = 1e-21
Identities = 74/237 (31%), Positives = 101/237 (42%), Gaps = 19/237 (8%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P+I PQD +C+A G P P I WL N LSM +LL DGTL++
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMI- 304
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSV--AVLREDFQIQPRDMVAV 149
TD G+Y C A N G ++ L + R F IQP++ +
Sbjct: 305 ----------QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVL 354
Query: 150 VGEQFTLECGPPWGHPEPTVSWWK-DGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCV 208
VGE TLEC GHP P +SW + D PL + P + G L + + D G Y C
Sbjct: 355 VGESVTLECSAT-GHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACS 413
Query: 209 ATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVW 265
ATN+ + A + PQ P + R+ +E T+ A+G P W
Sbjct: 414 ATNNIDSVHATAFIIVQALPQFTVTPQD----RVVIEGQTVDFQCEAKGNPPPVIAW 466
Score = 77.4 bits (189), Expect = 6e-14
Identities = 60/184 (32%), Positives = 75/184 (40%), Gaps = 16/184 (8%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHL-LPDGTLLL 90
PQ V PQD++ C+A G PPP I W G LS+ D HL L GTL +
Sbjct: 433 PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV---DRRHLVLSSGTLRI 489
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVV 150
G AL D G Y C+A N +G+ + F P D V
Sbjct: 490 ----------SGVALH-DQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEV 538
Query: 151 GEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVAT 210
G L C G PEP ++W KDG + H G L + +D G Y CVA
Sbjct: 539 GANVQLPCSSQ-GEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVAR 597
Query: 211 NSAG 214
N+ G
Sbjct: 598 NTIG 601
Score = 77.0 bits (188), Expect = 8e-14
Identities = 61/233 (26%), Positives = 98/233 (42%), Gaps = 28/233 (12%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPH-HLLPDGTLLL 90
P ++ PQ+ + C A+G PPP I W + + +P DP ++ P G L +
Sbjct: 342 PTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDR--TPLPVDPRVNITPSGGLYI 399
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVV 150
+ D G Y C A+N + + V A + V L + F + P+D V +
Sbjct: 400 QN-----------VVQGDSGEYACSATNNIDS-VHATAFIIVQALPQ-FTVTPQDRVVIE 446
Query: 151 GEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVAT 210
G+ +C G+P P ++W K G L++ +S G+L ++ D+G Y C A
Sbjct: 447 GQTVDFQCEAK-GNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAV 505
Query: 211 NSAGHR--------ESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPA 255
N G + + R V P D T V +QL + P+PA
Sbjct: 506 NIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEV---GANVQLPCSSQGEPEPA 555
Score = 35.0 bits (79), Expect = 0.36
Identities = 21/86 (24%), Positives = 34/86 (39%), Gaps = 13/86 (15%)
Query: 38 PQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARG 97
P D + ++ C + G+P P I W +G + + H+ P+G L +
Sbjct: 531 PSDTTVEVGANVQLPCSSQGEPEPAITWNKDG--VQVTESGKFHISPEGFLTI------- 581
Query: 98 HAHDGQALSTDLGVYTCEASNRLGTA 123
D G Y C A N +G+A
Sbjct: 582 ----NDVGPADAGRYECVARNTIGSA 603
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 101 bits (252), Expect = 3e-21
Identities = 119/430 (27%), Positives = 169/430 (39%), Gaps = 75/430 (17%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTL--- 88
P P D A + C+ SG P P I W +H+L G++
Sbjct: 480 PVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRE-----------NHILASGSVRIP 528
Query: 89 --LLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDM 146
+LL+ G D G YTC A+N G+ ++ A L+V R P D
Sbjct: 529 RFMLLES---GGLQIAPVFIQDAGNYTCYAANTEGS-LNASATLTVWN-RTSIVHPPEDH 583
Query: 147 VAVVGEQFTLECGPPWGHPEPTVS----WWKDGKPLALQPGRHTV--SGGSLLMARAEKS 200
V + G TL CG +P VS W KD L V GSLL+++
Sbjct: 584 VVIKGTTATLHCGATH---DPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSG 640
Query: 201 DEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKP 260
D G Y C + G+ +SR AR+ + E + + L++P+ +
Sbjct: 641 DIGDYSCEIVSEGGN-DSRMARLEVIELPHSPQNL-------------LVSPNSSHSH-- 684
Query: 261 RPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELL---AGWQSAELGGLHWGQ 317
AV LSW P + + +PW L + GL +
Sbjct: 685 --AVVLSW-----VRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPAR 737
Query: 318 DYEFKVRPSSGRARGPDS-NVLLLRLPEKVPSAPPQEVTLKPG-NGTVFVSWVPPPAENH 375
Y+F+V + RG S L LPE+ PSAPP+ + N ++ V W PPP H
Sbjct: 738 TYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEH 797
Query: 376 NGIIRGYQV----------WSLGNTSLPPANWTVVGEQTQLEIATHMPGSYCVQVAAVTG 425
NG++RGY + + N + P N+ +V T L I T Y +QVAA G
Sbjct: 798 NGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLV---TDLIIWT----QYEIQVAAYNG 850
Query: 426 AGAGEPSRPV 435
AG G SR V
Sbjct: 851 AGLGVFSRAV 860
Score = 60.1 bits (144), Expect = 1e-08
Identities = 103/427 (24%), Positives = 161/427 (37%), Gaps = 67/427 (15%)
Query: 31 PPQILVHPQDQLF-QGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLL 89
PP P+ ++ + + CQA G P PT++W + +S + + +L G L
Sbjct: 385 PPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGGLR 444
Query: 90 L--LQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMV 147
+ L+P D G++ C ASN G + L V + F +P D
Sbjct: 445 IQKLRP-------------EDSGIFQCFASNE-GGEIQTHTYLDVTNIAPVFTQRPVDTT 490
Query: 148 AVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQ----PGRHTVSGGSLLMARAEKSDEG 203
G L C G P+P ++W ++ LA P + G L +A D G
Sbjct: 491 VTDGMTAILRCEVS-GAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAG 549
Query: 204 TYMCVATNSAGHRESRAA-----RVSI-QEPQDYTEPVELLAVRIQLENVTLLNPDPAEG 257
Y C A N+ G + A R SI P+D+ V I+ TL
Sbjct: 550 NYTCYAANTEGSLNASATLTVWNRTSIVHPPEDH--------VVIKGTTATL---HCGAT 598
Query: 258 PKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQ 317
PR ++ WK A S + + + L++ S ++G
Sbjct: 599 HDPRVSLRYVWKKDNVALTPSSTSRIVVEKD---------GSLLISQTWSGDIG------ 643
Query: 318 DYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNG---TVFVSWVPPPAEN 374
DY ++ G DS + L + E S PQ + + P + V +SWV P +
Sbjct: 644 DYSCEIVSEGGN----DSRMARLEVIELPHS--PQNLLVSPNSSHSHAVVLSWVRP--FD 695
Query: 375 HNGIIRGYQVWSLGNTSLPPANWTVVG-EQTQLEIATHMPG-SYCVQVAAVTGAGAGEPS 432
N I Y V N S + + VG E T + ++ P +Y +V AV G G+ S
Sbjct: 696 GNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYS 755
Query: 433 RPVCLLL 439
L+
Sbjct: 756 AETSRLM 762
Score = 58.5 bits (140), Expect = 3e-08
Identities = 43/137 (31%), Positives = 68/137 (49%), Gaps = 6/137 (4%)
Query: 318 DYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGT-VFVSWVPPPAENHN 376
+YE +++ + GP S V+ R E VPSA P+ V+ + + T + ++W P ++ N
Sbjct: 1247 EYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQN 1306
Query: 377 GIIRGYQVWSLGNTSLP-PANWTVVGEQTQLEIATHMPG--SYCVQVAAVTGAGAGEPSR 433
G+I GY++ P P + V G TQ + + Y +QV A T G G PS
Sbjct: 1307 GLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPST 1366
Query: 434 PVCLLLEQAMERATQEP 450
P L+LE+ + A P
Sbjct: 1367 P--LILERTKDDAPGPP 1381
Score = 48.9 bits (115), Expect = 2e-05
Identities = 49/229 (21%), Positives = 82/229 (35%), Gaps = 23/229 (10%)
Query: 10 GGRG--SLPLLLLLIMGGMAQDS-PPQILVHPQ-DQLFQGPGPARMSCQASGQPPPTIRW 65
G RG +L L L ++ +AQD P P Q+ ++C A G P +W
Sbjct: 79 GRRGWWALLALQLHLLRALAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKW 138
Query: 66 LLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVS 125
+ + L+ + +++P L D G Y C NR+G +
Sbjct: 139 MRDDSELTTYSSEYKYIIPSLQKL------------------DAGFYRCVVRNRMGALLQ 180
Query: 126 RGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRH 185
R + + VA + R V+ G L P +P P V+W+++G +
Sbjct: 181 RKSEVQVAYMGSFMDTDQRKTVS-QGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIA 239
Query: 186 TVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEP 234
L++ SD G Y A N + + + +D P
Sbjct: 240 ITLENQLVILATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTP 288
Score = 45.4 bits (106), Expect = 3e-04
Identities = 41/130 (31%), Positives = 55/130 (42%), Gaps = 15/130 (11%)
Query: 315 WGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNG-TVFVSWVPPPAE 373
W Q YE +V +G G S + + VP+APPQ V + N T+ W PPP +
Sbjct: 838 WTQ-YEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQ 896
Query: 374 NHNGIIRGYQV--WSLGN-------TSLPPANWTVVGEQTQLEIATHMPGSYCVQVAAVT 424
NGI +GY++ W T P + G T L+ T +Y V T
Sbjct: 897 FINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFT----AYFTSVLCFT 952
Query: 425 GAGAGEPSRP 434
G G PS P
Sbjct: 953 TPGDGPPSTP 962
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/140 (30%), Positives = 64/140 (45%), Gaps = 6/140 (4%)
Query: 306 QSAELGGLHWGQDYEFKVRPSSGRARG-PDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVF 364
QSA L GL YE +V + G P + ++L R + P P + V + +V
Sbjct: 1336 QSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVR 1395
Query: 365 VSWVPPPAENHNGIIRGYQV-WSLGNTSLPPANWTVVGEQTQLEIATHM--PGSYCVQVA 421
+ W PP E NGII GYQ+ + L ++S VG + AT + +Y +++
Sbjct: 1396 IVWQPP--EEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLS 1453
Query: 422 AVTGAGAGEPSRPVCLLLEQ 441
A T G GEP + E+
Sbjct: 1454 AKTRQGWGEPLEATVITTEK 1473
Score = 39.3 bits (90), Expect = 0.019
Identities = 28/97 (28%), Positives = 42/97 (43%), Gaps = 8/97 (8%)
Query: 344 EKVPSAPPQEVTLKPGNGTVF-VSWVPPPAENHNGIIRGYQVW-----SLGNTSLPPANW 397
E P+ PQ V + P + V+W PPP E+ NG I+GY+++ S T +
Sbjct: 1698 EAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLF 1757
Query: 398 TVVGEQTQLEIATHMPGSYCVQVAAVTGAGAGEPSRP 434
+ +H Y V ++A AG G S P
Sbjct: 1758 LPEPVVRLKNLTSHT--KYLVSISAFNAAGDGPKSDP 1792
Score = 37.4 bits (85), Expect = 0.072
Identities = 15/43 (34%), Positives = 26/43 (60%), Gaps = 1/43 (2%)
Query: 344 EKVPSAPPQEVTLKPGN-GTVFVSWVPPPAENHNGIIRGYQVW 385
+ VP PP V+ P +V + W PP E+ NG+++GY+++
Sbjct: 1575 QDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIY 1617
Score = 30.4 bits (67), Expect = 8.7
Identities = 33/111 (29%), Positives = 44/111 (39%), Gaps = 26/111 (23%)
Query: 332 GPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGIIRGYQVWSLGNTS 391
GP S L+ E P A + + ++ VSW P +N GII GYQ+
Sbjct: 957 GPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKN--GIITGYQI------- 1007
Query: 392 LPPANWTVVGEQTQ-----LEIATH---MPG-----SYCVQVAAVTGAGAG 429
+W V G L TH + G +Y + VAAVT G G
Sbjct: 1008 ----SWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTG 1054
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 100 bits (250), Expect = 5e-21
Identities = 108/434 (24%), Positives = 169/434 (38%), Gaps = 66/434 (15%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P I + PQ ++ + A M C ASG P P I W + +P DP +G + L
Sbjct: 135 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKD-----FLPVDPS--ASNGRIKQL 187
Query: 92 QP------PARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRE------DF 139
+ P RG + TD G Y C A+N G S A L V LRE F
Sbjct: 188 RSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRF 247
Query: 140 QIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEK 199
I P + G + C G P P V W + + L + + G ++ +
Sbjct: 248 SILPMSHEIMPGGNVNITC-VAVGSPMPYVKWMQGAEDLTPE---DDMPVGRNVLELTDV 303
Query: 200 SDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPK 259
D Y CVA +S G E+ A +I ++++ P
Sbjct: 304 KDSANYTCVAMSSLGVIEAVA--------------------QITVKSLPKAPGTPMVTEN 343
Query: 260 PRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDY 319
++ ++W SG P Y +++++ Q P+ + +GGL +Y
Sbjct: 344 TATSITITWD-SGNPDPVSYYVIEYKSKS----QDGPYQIKEDITTTRYSIGGLSPNSEY 398
Query: 320 EFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGII 379
E V + +GP S ++ R E+ P++ P+ V + + T + P E NG+I
Sbjct: 399 EIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVE-PNGLI 457
Query: 380 RGYQVWSLGNTSLPPANW----------TVVGEQTQLEIATHMPGSYCVQVAAVTGAGAG 429
RGY+V+ P NW T VG + E +Y V+V A T G G
Sbjct: 458 RGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDE-------TYTVRVLAFTSVGDG 510
Query: 430 EPSRPVCLLLEQAM 443
S P+ + +Q +
Sbjct: 511 PLSDPIQVKTQQGV 524
Score = 94.0 bits (232), Expect = 6e-19
Identities = 72/248 (29%), Positives = 110/248 (44%), Gaps = 42/248 (16%)
Query: 5 GDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIR 64
G ++ G + LL++L++GG A + PP+ + P+DQ+ G A CQA+G P P +
Sbjct: 6 GPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVT 65
Query: 65 W-----LLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNR 119
W +N Q + D G +L +QP D VY C A N
Sbjct: 66 WNKKGKKVNSQRFETIEFDE----SAGAVLRIQP---------LRTPRDENVYECVAQNS 112
Query: 120 LGTAVSRGARLSVAVLRED--------FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW 171
+G + VLRED + P+ V T+ C G+P+P ++W
Sbjct: 113 VGEIT---VHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS-GNPDPEITW 168
Query: 172 WKDGKP------------LALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESR 219
+KD P L + T G+L + +E++D+G Y CVATNSAG R S
Sbjct: 169 FKDFLPVDPSASNGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSS 228
Query: 220 AARVSIQE 227
A + ++E
Sbjct: 229 PANLYVRE 236
Score = 55.5 bits (132), Expect = 3e-07
Identities = 45/156 (28%), Positives = 64/156 (41%), Gaps = 5/156 (3%)
Query: 318 DYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGT-VFVSWVPPPAENHN 376
+Y F++ S + G + V+ R + PSAPPQ+V T + VSW PPP E HN
Sbjct: 589 EYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHN 648
Query: 377 GIIRGYQV--WSLGNTSLPPANWTVVGEQTQ--LEIATHMPGSYCVQVAAVTGAGAGEPS 432
G + GY V LG+ P + T L A Y + A T G G S
Sbjct: 649 GALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPES 708
Query: 433 RPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468
PV + ++ + A E +R + P
Sbjct: 709 SPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSP 744
Score = 50.8 bits (120), Expect = 6e-06
Identities = 38/128 (29%), Positives = 59/128 (46%), Gaps = 16/128 (12%)
Query: 332 GPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVF-VSWVPPPAENHNGIIRGYQVW----- 385
GP+S+ +++R E VPSAPP++V + N T V W P +G IRGYQV
Sbjct: 705 GPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRME 764
Query: 386 --------SLGNTSLPPANWTVVGEQTQLEIATHM--PGSYCVQVAAVTGAGAGEPSRPV 435
+ + L A W + T++ +Y + VAA T G G S+P
Sbjct: 765 GAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPK 824
Query: 436 CLLLEQAM 443
++ + A+
Sbjct: 825 VVVTKGAV 832
Score = 47.8 bits (112), Expect = 5e-05
Identities = 42/133 (31%), Positives = 57/133 (42%), Gaps = 10/133 (7%)
Query: 312 GLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ--EVTLKPGNGTVFVSWVP 369
G+H G Y F++ S G ++ +L +PE P PQ E GTV + W+P
Sbjct: 894 GVHKGATYVFRLAARSRGGLGEEA-AEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLP 952
Query: 370 PPAENHNGIIRGYQVWSLGNTSLPPANWTVV------GEQTQLEIATHMPG-SYCVQVAA 422
P NG I Y V +L PA T + G + L + P +Y +QV A
Sbjct: 953 PVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRA 1012
Query: 423 VTGAGAGEPSRPV 435
T G G S PV
Sbjct: 1013 HTRRGPGPFSPPV 1025
Score = 40.0 bits (92), Expect = 0.011
Identities = 29/93 (31%), Positives = 43/93 (46%), Gaps = 6/93 (6%)
Query: 142 QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR---HTVSGGSLLMARAE 198
+P+D + V G + C G P+P V+W K GK + Q S G++L +
Sbjct: 38 EPKDQIGVSGGVASFVCQAT-GDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPL 96
Query: 199 KS--DEGTYMCVATNSAGHRESRAARVSIQEPQ 229
++ DE Y CVA NS G A ++E Q
Sbjct: 97 RTPRDENVYECVAQNSVGEITVHAKLTVLREDQ 129
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 99.4 bits (246), Expect = 2e-20
Identities = 63/203 (31%), Positives = 92/203 (45%), Gaps = 16/203 (7%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P+I PQD +C+A G P P I W+ N L + ++ DGTL++
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIR 293
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVL--REDFQIQPRDMVAV 149
+D GVY C A N G A ++ A L + L + F IQP+D +
Sbjct: 294 N-----------TRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVL 342
Query: 150 VGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVA 209
+G TLEC GHP P ++W +D L L RH + L + + D G + C A
Sbjct: 343 IGTSTTLECMAT-GHPHPLITWTRDNG-LELDGSRHVATSSGLYLQNITQRDHGRFTCHA 400
Query: 210 TNSAGHRESRAARVSIQEPQDYT 232
NS G ++ AA + +Q P +T
Sbjct: 401 NNSHGTVQA-AANIIVQAPPQFT 422
Score = 79.3 bits (194), Expect = 2e-14
Identities = 58/186 (31%), Positives = 81/186 (43%), Gaps = 16/186 (8%)
Query: 30 SPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLL 89
+PPQ V P+DQ+ C+A G PPP I W G L + H +L GTL
Sbjct: 417 APPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--EGQHTVLSSGTLR 474
Query: 90 LLQPPARGHAHDGQALSTDLGVYTCEASNRLGTA-VSRGARLSVAVLREDFQIQPRDMVA 148
+ +A D G Y C+A + LG VS + L Q+ P+D
Sbjct: 475 I-----------DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQL-PQDTSV 522
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCV 208
VG+ + C G P+P ++W K+G + H G+L + A D+G Y CV
Sbjct: 523 EVGKNINISCHAQ-GEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECV 581
Query: 209 ATNSAG 214
A NS G
Sbjct: 582 ARNSFG 587
Score = 70.5 bits (171), Expect = 8e-12
Identities = 61/209 (29%), Positives = 86/209 (41%), Gaps = 29/209 (13%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLL-NGQPLSMVPPDPHHLLPDGTLLL 90
P ++ PQD + C A+G P P I W NG L H+ L L
Sbjct: 330 PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELD----GSRHVATSSGLYL 385
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVV 150
R H G +TC A+N GT + A + F + P+D V +
Sbjct: 386 QNITQRDH-----------GRFTCHANNSHGTV--QAAANIIVQAPPQFTVTPKDQVVLE 432
Query: 151 GEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTV-SGGSLLMARAEKSDEGTYMCVA 209
C G+P P + W K G L ++ G+HTV S G+L + RA + D+G Y C A
Sbjct: 433 EHAVEWLCEAD-GNPPPVIVWTKTGGQLPVE-GQHTVLSSGTLRIDRAAQHDQGQYECQA 490
Query: 210 TNSAGHR--------ESRAARVSIQEPQD 230
+S G + + +A V Q PQD
Sbjct: 491 VSSLGVKKVSVQLTVKPKALAVFTQLPQD 519
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 97.8 bits (242), Expect = 4e-20
Identities = 105/428 (24%), Positives = 168/428 (39%), Gaps = 63/428 (14%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P I + PQ ++ + A M C ASG P P I W + +P DP +G + L
Sbjct: 135 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKD-----FLPVDPS--ASNGRIKQL 187
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVV- 150
+ G + TD G Y C A+N G S A L V LRE ++ PR + +
Sbjct: 188 RS---GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSILPMS 244
Query: 151 -----GEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTY 205
G + C G P P V W + + L + G ++ + D Y
Sbjct: 245 HEIMPGGNVNITCVAV-GSPMPYVKWMQGAEDLTPEDDMPV---GRNVLELTDVKDSANY 300
Query: 206 MCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVW 265
CVA +S G E+ A +I ++++ P ++
Sbjct: 301 TCVAMSSLGVIEAVA--------------------QITVKSLPKAPGTPMVTENTATSIT 340
Query: 266 LSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKVRP 325
++W SG P Y +++++ G P+ + +GGL +YE V
Sbjct: 341 ITWD-SGNPDPVSYYVIEYKSKSQDG----PYQIKEDITTTRYSIGGLSPNSEYEIWVSA 395
Query: 326 SSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGIIRGYQVW 385
+ +GP S ++ R E+ P++ P+ V + + T + P E NG+IRGY+V+
Sbjct: 396 VNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVE-PNGLIRGYRVY 454
Query: 386 SLGNTSLPPANW----------TVVGEQTQLEIATHMPGSYCVQVAAVTGAGAGEPSRPV 435
P NW T VG + E +Y V+V A T G G S P+
Sbjct: 455 YTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDE-------TYTVRVLAFTSVGDGPLSDPI 507
Query: 436 CLLLEQAM 443
+ +Q +
Sbjct: 508 QVKTQQGV 515
Score = 97.4 bits (241), Expect = 6e-20
Identities = 72/239 (30%), Positives = 112/239 (46%), Gaps = 33/239 (13%)
Query: 5 GDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIR 64
G ++ G + LL++L++GG A + PP+ + P+DQ+ G A CQA+G P P +
Sbjct: 6 GPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVT 65
Query: 65 W-----LLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNR 119
W +N Q + D G +L +QP D VY C A N
Sbjct: 66 WNKKGKKVNSQRFETIEFDE----SAGAVLRIQP---------LRTPRDENVYECVAQNS 112
Query: 120 LGTAVSRGARLSVAVLRED--------FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW 171
+G + VLRED + P+ V T+ C G+P+P ++W
Sbjct: 113 VGEIT---VHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS-GNPDPEITW 168
Query: 172 WKDGKPL--ALQPGR-HTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQE 227
+KD P+ + GR + G+L + +E++D+G Y CVATNSAG R S A + ++E
Sbjct: 169 FKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRE 227
Score = 40.0 bits (92), Expect = 0.011
Identities = 29/93 (31%), Positives = 43/93 (46%), Gaps = 6/93 (6%)
Query: 142 QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR---HTVSGGSLLMARAE 198
+P+D + V G + C G P+P V+W K GK + Q S G++L +
Sbjct: 38 EPKDQIGVSGGVASFVCQAT-GDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPL 96
Query: 199 KS--DEGTYMCVATNSAGHRESRAARVSIQEPQ 229
++ DE Y CVA NS G A ++E Q
Sbjct: 97 RTPRDENVYECVAQNSVGEITVHAKLTVLREDQ 129
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 97.4 bits (241), Expect = 6e-20
Identities = 66/201 (32%), Positives = 94/201 (46%), Gaps = 27/201 (13%)
Query: 25 GMAQDSPPQILVHPQDQLFQGP----GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPH 80
G+ + PP+I + P GP P R++C A+G P PT+ WL +G P+S
Sbjct: 1970 GLRVNVPPRITLPPS---LPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGL 2026
Query: 81 HLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLG---TAVSRGARLSVAVLRE 137
+ P G +L L A ++D G Y+C A + +G V + ++L E
Sbjct: 2027 QVFPGGRVLTL----------ASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGE 2076
Query: 138 DFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMA-R 196
+ + V E LEC P P +SWWKDG+PL +PG H + +LL R
Sbjct: 2077 ELNVS-----VVANESVALEC-QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDR 2130
Query: 197 AEKSDEGTYMCVATNSAGHRE 217
A+ D G Y C A N AGH E
Sbjct: 2131 ADVWDAGHYTCEALNQAGHSE 2151
Score = 88.6 bits (218), Expect = 3e-17
Identities = 60/185 (32%), Positives = 83/185 (44%), Gaps = 20/185 (10%)
Query: 47 GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALS 106
G ++ C G P P I W+ +G PL H L +G+L + +
Sbjct: 4234 GSIQLDCVVRGDPVPDIHWIKDGLPLR--GSHLRHQLQNGSLTIHRTER----------- 4280
Query: 107 TDLGVYTCEASNRLGTAVSRGARLSVAVLRED--FQIQPRDMVAVVGEQFTLECGPPWGH 164
D G Y C A N +G A ++ + VL+ FQ++P+DM G+ L C G
Sbjct: 4281 DDAGRYQCLAENEMGVA----KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT-GE 4335
Query: 165 PEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVS 224
P PT+ W + G+PL T+ GSL + E D GTY CVA N G +RA V
Sbjct: 4336 PTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 4395
Query: 225 IQEPQ 229
EPQ
Sbjct: 4396 RGEPQ 4400
Score = 86.3 bits (212), Expect = 1e-16
Identities = 60/174 (34%), Positives = 84/174 (48%), Gaps = 22/174 (12%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
P + C+A G PPP IRW +P+S P + +LL G +L + Q
Sbjct: 2369 PLTLLCEAMGIPPPAIRWFRGEEPVS--PGEDTYLLAGGWMLKMT----------QTQEQ 2416
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVV----GEQFTLECGPPWG 163
D G+Y+C ASN G A SV VL I+ D+ V+ G+ L C G
Sbjct: 2417 DSGLYSCLASNEAGEA---RRNFSVEVLVPP-SIENEDLEEVIKVLDGQTAHLMCNVT-G 2471
Query: 164 HPEPTVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGHR 216
HP+P ++W+KDG+PLA H G LL + +A S G Y C+A N+ G +
Sbjct: 2472 HPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 2525
Score = 85.9 bits (211), Expect = 2e-16
Identities = 67/186 (36%), Positives = 91/186 (48%), Gaps = 16/186 (8%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
P +SC+ G P P I W +GQPL H+ G LL L GQA
Sbjct: 2179 PTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYL----------GQAQLA 2228
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAVLRE-DFQIQPRDMVAVVGEQF-TLECGPPWGHP 165
G YTCE SN +G + S+ +L V V + +P V+VV + TLEC G P
Sbjct: 2229 QEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKP 2286
Query: 166 EPTVSWWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVS 224
PTV+W +DG+P+ + G + G SL + RA+ + G Y CVA N AG R R +S
Sbjct: 2287 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELS 2345
Query: 225 IQEPQD 230
+ P +
Sbjct: 2346 VLVPPE 2351
Score = 85.1 bits (209), Expect = 3e-16
Identities = 80/255 (31%), Positives = 110/255 (43%), Gaps = 45/255 (17%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPH-HLLPDGTLLLLQPPARGHAHDGQALSTDL 109
+ C A G P PTI WL NG P S P P +L DG +L + A D
Sbjct: 2865 LQCPALGNPVPTISWLQNGLPFS---PSPRLQVLEDGQVLQV----------STAEVADA 2911
Query: 110 GVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTV 169
Y C A N+ G+A + L V V + + A++ +L C HP P V
Sbjct: 2912 ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPC-DVHAHPNPEV 2969
Query: 170 SWWKD------GKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARV 223
+W+KD G+ + L PG HT L + RA SD G Y C A N+AG R+ + ++
Sbjct: 2970 TWYKDSQALSLGEEVFLLPGTHT-----LQLGRARLSDSGMYTCEALNAAG-RDQKLVQL 3023
Query: 224 SIQEPQDYTE----PVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSG-PAAPAQ 278
S+ P + + P + + VR+ + V D P P V +W G P AQ
Sbjct: 3024 SVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL----PEPTV--TWYKDGQPLVLAQ 3077
Query: 279 SYTALFRTQTAPGGQ 293
RTQ GGQ
Sbjct: 3078 ------RTQALRGGQ 3086
Score = 83.2 bits (204), Expect = 1e-15
Identities = 89/302 (29%), Positives = 127/302 (42%), Gaps = 55/302 (18%)
Query: 50 RMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDL 109
++ C+A G P P I W +G LLP T ++ R G+A S+D
Sbjct: 1521 QLLCEARGVPTPNITWFKDGA-----------LLPTSTKVVYTRGGR-QLQLGRAQSSDA 1568
Query: 110 GVYTCEASNRLGTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHPEP 167
GVYTC+ASN +G A + RL V V E +P + AV G LEC GHP P
Sbjct: 1569 GVYTCKASNAVG-AAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC-VARGHPSP 1626
Query: 168 TVSWWKDGKPLALQPGRHTVSGGSLLMARAE-KSDEGTYMCVATNSAGHRESRAARVSIQ 226
T+SW +G P+A + GS+L + ++ G Y CVA++ AG + + V +Q
Sbjct: 1627 TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYS-VEVQ 1685
Query: 227 EPQDYTEPVELLAVRIQLENVTLLNPDPAEGP-----KPRPAV-WL-----SWKVSGPAA 275
P L V L VT + P E P P P + WL + +++G
Sbjct: 1686 VPPQ-------LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQV 1738
Query: 276 PAQ-----------SYTALFRTQTAPGGQGAPWAE-------ELLAGWQSAELGGLHWGQ 317
+Q ++ LF Q A G AE E G +G HWG
Sbjct: 1739 ASQGTTLHIDHVELDHSGLFACQ-ATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGX 1797
Query: 318 DY 319
++
Sbjct: 1798 EH 1799
Score = 80.9 bits (198), Expect = 6e-15
Identities = 81/239 (33%), Positives = 112/239 (46%), Gaps = 32/239 (13%)
Query: 50 RMSCQASGQPPPTIRWLLNGQPLSM-VPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTD 108
R+ C+A GQPPP + WL +G PL + P L G+L+L +G ++D
Sbjct: 3236 RLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVL-----KG------LRASD 3284
Query: 109 LGVYTCEASNRLGTAVSRGARL-SVAVLREDFQIQPRD----MVAVVGEQFTLECGPPWG 163
G YTC A N G ARL +V VL Q D +V+ GE T+ C P G
Sbjct: 3285 AGAYTCVAHNPAG----EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC-PVRG 3339
Query: 164 HPEPTVSWWKDGKPLALQPGRHTV---SGGSLLMARAEKSDEGTYMCVATNSAGHRESRA 220
P VSW KDG PL L + T+ SG +L +++ + +D G + CVA + AG + R
Sbjct: 3340 SPPIHVSWLKDGLPLPL--SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVAD-RN 3396
Query: 221 ARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQS 279
+ +Q P EPVE + + + P A G P P V SW G +QS
Sbjct: 3397 FTLQVQVP-PVLEPVEFQNDVVVVRGSLVELPCEARG-VPLPLV--SWMKDGEPLLSQS 3451
Score = 80.5 bits (197), Expect = 7e-15
Identities = 64/188 (34%), Positives = 89/188 (47%), Gaps = 19/188 (10%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C P P + W + Q LS+ + LLP L L G+A +D G
Sbjct: 2957 LPCDVHAHPNPEVTWYKDSQALSL--GEEVFLLPGTHTLQL----------GRARLSDSG 3004
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQIQ--PRDMVAV-VGEQFTLECGPPWGHPEP 167
+YTCEA N G + +LSV V Q P+D V V VG++ L C PEP
Sbjct: 3005 MYTCEALNAAGRD-QKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETD-ALPEP 3062
Query: 168 TVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGHRESRAARVSIQ 226
TV+W+KDG+PL L + GG L + A+ SD+G Y C +N AG R +++Q
Sbjct: 3063 TVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQ 3121
Query: 227 EPQDYTEP 234
P + P
Sbjct: 3122 VPPTFENP 3129
Score = 80.1 bits (196), Expect = 1e-14
Identities = 87/288 (30%), Positives = 115/288 (39%), Gaps = 59/288 (20%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP+I + PA + C ASG P PTI W L+ P +++ +GTLL+
Sbjct: 975 PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH-YNVSKEGTLLI 1033
Query: 91 LQPPAR------------------------------------------GHAHDGQALSTD 108
QP A+ G Q D
Sbjct: 1034 AQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGD 1093
Query: 109 LGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPT 168
G Y C ASN G+A R L V V Q PR + +VGE L C G+PEP
Sbjct: 1094 SGHYECTASNPAGSASHRYV-LGVQV-PPQVQPGPRVLKVLVGEALDLNCVAE-GNPEPQ 1150
Query: 169 VSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEP 228
+SW KDG L GR GS+ A SD G Y C A+NSAG ++ P
Sbjct: 1151 LSWSKDGVVL---QGRG--PQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPP 1205
Query: 229 QDYTEPVELLAVRIQLENVTLLNPDPAEG-PKPRPAVWLSWKVSGPAA 275
+ L R+ EN +L P PA G PKP+ ++W+ GP++
Sbjct: 1206 HWGADETSGLLERVAGENASL--PCPARGTPKPQ----VTWR-KGPSS 1246
Score = 79.3 bits (194), Expect = 2e-14
Identities = 72/254 (28%), Positives = 116/254 (45%), Gaps = 38/254 (14%)
Query: 5 GDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGP------------GPARMS 52
G + L G+ ++G +QD ++ V PQ GP G A +
Sbjct: 2223 GQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ---IAGPREPPTQVSVVQDGVATLE 2279
Query: 53 CQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHA-HDGQALSTDLGV 111
C A+G+PPPT+ W +GQP+ G L LQ +G + H +A + G
Sbjct: 2280 CNATGKPPPTVTWERDGQPV-------------GAELGLQLQNQGQSLHVERAQAAHTGR 2326
Query: 112 YTCEASNRLGTAVSRGARLSVAVLREDF-QIQP-RDMVAVVGEQFTLECGPPWGHPEPTV 169
Y+C A N G A R LSV V E + P ++ A + TL C G P P +
Sbjct: 2327 YSCVAENLAGRA-ERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLC-EAMGIPPPAI 2384
Query: 170 SWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGH-RESRAARVSIQ- 226
W++ +P++ + ++GG +L M + ++ D G Y C+A+N AG R + + V +
Sbjct: 2385 RWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPP 2444
Query: 227 --EPQDYTEPVELL 238
E +D E +++L
Sbjct: 2445 SIENEDLEEVIKVL 2458
Score = 79.0 bits (193), Expect = 2e-14
Identities = 65/235 (27%), Positives = 100/235 (42%), Gaps = 33/235 (14%)
Query: 17 LLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVP 76
LL I+GG + ++ V + P + C+A P P I W+ +G P
Sbjct: 2534 LLAPTILGGAEDSADEEVTVTVNN-------PISLICEALAFPSPNITWMKDGAPFEA-- 2584
Query: 77 PDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSR---GARLSVA 133
+ L P G A D G YTC +N LG AV + +
Sbjct: 2585 ---------SRNIQLLPGTHG-LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 2634
Query: 134 VLRED--FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGS 191
+ ++D ++ +++ V TLEC W P PT+ W+KDG+P+ + G
Sbjct: 2635 ISKDDPLGEVGVKEVKTKVNSTLTLEC-ESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 2693
Query: 192 LLMAR-AEKSDEGTYMCVATNSAGHRESRAARVSIQEPQ------DYTEPVELLA 239
LL + + SD G Y+CVATN AG + + V IQ P D++ E+L+
Sbjct: 2694 LLQIQPTQVSDSGRYLCVATNVAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILS 2747
Score = 79.0 bits (193), Expect = 2e-14
Identities = 60/200 (30%), Positives = 84/200 (42%), Gaps = 20/200 (10%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP I D P ++C ++G P PT+ W G L + + P G L +
Sbjct: 3856 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG-ARGSGYRVSPSGALEI 3914
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMV--A 148
GQAL G YTC A N G A ++ ++P V A
Sbjct: 3915 -----------GQALPIHAGRYTCSARNSAGVAHKH----VFLTVQASPVVKPLPSVVRA 3959
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCV 208
V E+ L C G P PT++W K+G +A + GG L +A A D G Y+C+
Sbjct: 3960 VAEEEVLLPCEAS-GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCI 4018
Query: 209 ATNSAGHRESRAARVSIQEP 228
A NSAG + R+ +Q P
Sbjct: 4019 AKNSAGSAMGK-TRLVVQVP 4037
Score = 78.6 bits (192), Expect = 3e-14
Identities = 69/207 (33%), Positives = 95/207 (45%), Gaps = 15/207 (7%)
Query: 26 MAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLL-NGQPLSMVPPDPHHLLP 84
+A PQ+ P+D + A ++C+A+G+PPPT+ W +GQPL + L
Sbjct: 780 LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGL-------RLG 832
Query: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
G + P G D Y CEA N G V ARL V
Sbjct: 833 AGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGK-VQAEARLIVTGHAPPQIASSA 891
Query: 145 DMVAVV-GEQFTLECGPPWGHPEPTVSWWKDGKPLALQPG-RHTV-SGGSLLMARAEKSD 201
V V+ G+ +L C G P P W KDG+PL PG RH++ + GSL + RA +
Sbjct: 892 PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLP--PGSRHSIRADGSLHLDRALQEH 949
Query: 202 EGTYMCVATNSAGHRESRAARVSIQEP 228
G Y CVATN+AG + R + +Q P
Sbjct: 950 AGRYSCVATNTAG-SQHRDVELVVQVP 975
Score = 75.9 bits (185), Expect = 2e-13
Identities = 112/438 (25%), Positives = 155/438 (35%), Gaps = 63/438 (14%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PPQ+ P+ ++C A G P P + W DG +L
Sbjct: 1119 PPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWS-----------------KDGVVLQ 1161
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRD---MV 147
+ P +G H ++D G Y CEASN G + + VL +
Sbjct: 1162 GRGP-QGSVHFAAIRTSDAGRYRCEASNSAGVDAWE---VELRVLEPPHWGADETSGLLE 1217
Query: 148 AVVGEQFTLECGPPWGHPEPTVSWWK--DGKPLALQPGRHTVSGGSLLMARAEKSDEGTY 205
V GE +L C P G P+P V+W K +PL QPG + GSL +A +D G Y
Sbjct: 1218 RVAGENASLPC-PARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDY 1276
Query: 206 MCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVW 265
C ATN G SR A++ + P E V L D P P VW
Sbjct: 1277 ECQATNEVG-STSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE-IVW 1334
Query: 266 L--SWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQD--YEF 321
L + V P A L G G LL QS + G Y
Sbjct: 1335 LKDAQLVGVPLGWAGYGWDL--------GWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSC 1386
Query: 322 KVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGIIRG 381
+ +G A+ D ++L+L P + + QEV G
Sbjct: 1387 RAENQAGTAQ-RDFHLLVLTPPSVLGAGAAQEVLGLAGADVEL----------------- 1428
Query: 382 YQVWSLGNTSLPPANWTVVGEQTQLEIATHMPGSYCVQVAAVTGAGAGEPSRPVCLLLEQ 441
Q W+ G P WT Q L H+ QV +TG+ G+ R C+
Sbjct: 1429 -QCWTSG-VPTPQVEWT-KDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 1485
Query: 442 AMERATQ-EPSEHGPWTL 458
A ++A + H P T+
Sbjct: 1486 AGQQARDFQLRVHAPPTI 1503
Score = 75.9 bits (185), Expect = 2e-13
Identities = 59/170 (34%), Positives = 78/170 (45%), Gaps = 17/170 (10%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C+ASG P PTI W G L++ +LP G L + AH A D G
Sbjct: 3967 LPCEASGIPRPTITWQKEG--LNVATGVSTQVLPGGQLRI--------AH---ASPEDAG 4013
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVS 170
Y C A N G+A+ + RL V V P D+ G L C G PEP ++
Sbjct: 4014 NYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLP-DLSTTEGSHAFLPCKAR-GSPEPNIT 4070
Query: 171 WWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEGTYMCVATNSAGHRESR 219
W KDG+P++ G+ T+ G LL+ E D GTY C A N+ G R
Sbjct: 4071 WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRR 4120
Score = 74.7 bits (182), Expect = 4e-13
Identities = 60/177 (33%), Positives = 81/177 (45%), Gaps = 16/177 (9%)
Query: 38 PQDQLFQGPGP-ARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPAR 96
PQD + G A +SC+ P PT+ W +GQPL V L G L +Q
Sbjct: 3038 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPL--VLAQRTQALRGGQRLEIQ---- 3091
Query: 97 GHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTL 156
+A +D G+Y+C+ SN G AV R L+V V + + V G L
Sbjct: 3092 ------EAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVL 3144
Query: 157 ECGPPWGHPEPTVSWWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEGTYMCVATNS 212
C G P PTV+W KD P+ VS GG L ++R + + GTY CVA N+
Sbjct: 3145 TCDVS-GVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENT 3200
Score = 74.3 bits (181), Expect = 5e-13
Identities = 80/270 (29%), Positives = 109/270 (40%), Gaps = 38/270 (14%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSM-VPPDPHHLLPDGTLL 89
PP I P + PA + C+ASG P P + W +GQ L + + LLP LL
Sbjct: 3763 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 3822
Query: 90 LLQPPARGHAHDGQALSTDLGVYTCEASNRLGTA-----VSRGARLSVAVLREDFQIQPR 144
L P + D + C SN +G A V+ ++A + DF +
Sbjct: 3823 LTAPGPQ-----------DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTV--- 3868
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEG 203
M+A V L C G P PTVSW K G L + + VS G+L + +A G
Sbjct: 3869 TMMAPV----VLTCHST-GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAG 3923
Query: 204 TYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Y C A NSAG P +P+ + + E V L P A G PRP
Sbjct: 3924 RYTCSARNSAGVAHKHVFLTVQASP--VVKPLPSVVRAVAEEEVLL--PCEASG-IPRPT 3978
Query: 264 VWLSWKVSGPAAPAQSYTALFRTQTAPGGQ 293
+ +W+ G + TQ PGGQ
Sbjct: 3979 I--TWQKEG-----LNVATGVSTQVLPGGQ 4001
Score = 74.3 bits (181), Expect = 5e-13
Identities = 64/211 (30%), Positives = 93/211 (44%), Gaps = 22/211 (10%)
Query: 49 ARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTD 108
A + C+A G P P I W +GQP+S + P G LL+ +GQ D
Sbjct: 4055 AFLPCKARGSPEPNITWDKDGQPVSGA-EGKFTIQPSGELLVKN-------LEGQ----D 4102
Query: 109 LGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPT 168
G YTC A N +G A R L++ VL F P D +G++ L C G P P
Sbjct: 4103 AGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDRLWLRCAAR-GSPTPR 4159
Query: 169 VSWWKDGKPLALQPGRHTVSGGSLLM-ARAEKSDEGTYMCVATNSAGHRES----RAARV 223
+ W + +P+ G GGS L A + D GTY+C A N G ++
Sbjct: 4160 IGWTVNDRPVT--EGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 4217
Query: 224 SIQEPQDYTEPVELLAVRIQLENVTLLNPDP 254
+ + + ++ VE + IQL+ V +P P
Sbjct: 4218 PVLQGEAFSYLVEPVGGSIQLDCVVRGDPVP 4248
Score = 73.6 bits (179), Expect = 9e-13
Identities = 53/173 (30%), Positives = 82/173 (47%), Gaps = 16/173 (9%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
PA + C + PPP + W QPLS D +L G +L + P R +
Sbjct: 2767 PAYLYCDTNAIPPPDLTWYREDQPLS--AGDEVSVLQGGRVLQI-PLVR---------AE 2814
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVA--VLREDFQIQPRDMVAVVGEQFTLECGPPWGHP 165
+ G Y+C+ASN +G L + V+ D + ++ +L+C P G+P
Sbjct: 2815 NAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-PALGNP 2873
Query: 166 EPTVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGHRE 217
PT+SW ++G P + P + G +L ++ AE +D +YMCVA N AG E
Sbjct: 2874 VPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE 2926
Score = 73.6 bits (179), Expect = 9e-13
Identities = 66/195 (33%), Positives = 85/195 (43%), Gaps = 30/195 (15%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHD---GQALST 107
M C G PP + WL +G PL L TLL G H +
Sbjct: 3333 MVCPVRGSPPIHVSWLKDGLPLP---------LSQRTLL------HGSGHTLRISKVQLA 3377
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHP 165
D G++TC A++ G A R L V V + E + Q D+V V G L C G P
Sbjct: 3378 DAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQ-NDVVVVRGSLVELPCEAR-GVP 3434
Query: 166 EPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSI 225
P VSW KDG+PL Q G SL + D GTY CVA + AG R ++++
Sbjct: 3435 LPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR-RHFQLTV 3490
Query: 226 QEP---QDYTEPVEL 237
EP +D +P EL
Sbjct: 3491 MEPPHIEDSGQPTEL 3505
Score = 72.8 bits (177), Expect = 2e-12
Identities = 76/256 (29%), Positives = 104/256 (40%), Gaps = 44/256 (17%)
Query: 31 PPQILVHP---QDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGT 87
PPQ+LV Q G P + CQASG P PTI+WL NG+P + + GT
Sbjct: 1687 PPQLLVAEGLGQVTTIVGQ-PLELPCQASGSPVPTIQWLQNGRPAEELA--GVQVASQGT 1743
Query: 88 LLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMV 147
L + H+ G++ C+A+N GTA GA + V+V E P +
Sbjct: 1744 TLHIDHVELDHS----------GLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLE 1787
Query: 148 AVVGE---------QFTLECGPP----WG-HPE-PTVSWWKDGKPLALQPGRHTVSGG-- 190
+G+ F C PP WG HP+ P V W L +P V+
Sbjct: 1788 VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 1847
Query: 191 -SLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTL 249
L + + + DEG Y C ATN AG + A + P PV + LEN ++
Sbjct: 1848 PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVN----KAVLENASV 1903
Query: 250 LNPDPAEGPKPRPAVW 265
A G P W
Sbjct: 1904 TLECLASGVPPPDVSW 1919
Score = 72.4 bits (176), Expect = 2e-12
Identities = 77/265 (29%), Positives = 108/265 (40%), Gaps = 52/265 (19%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST-DL 109
+ C A G P P I W +N +P++ + DG G A+S D
Sbjct: 4148 LRCAARGSPTPRIGWTVNDRPVTEGVSEQ-----DG----------GSTLQRAAVSREDS 4192
Query: 110 GVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRD---MVAVVGEQFTLECGPPWGHPE 166
G Y C A NR+G R +S ++E +Q +V VG L+C G P
Sbjct: 4193 GTYVCWAENRVG----RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR-GDPV 4247
Query: 167 PTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRES------RA 220
P + W KDG PL RH + GSL + R E+ D G Y C+A N G + ++
Sbjct: 4248 PDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQS 4307
Query: 221 ARVSIQEPQDYT-EPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQS 279
A V EPQD T + +A+R Q +P P + W +G Q
Sbjct: 4308 APVFQVEPQDMTVRSGDDVALRCQATG------------EPTPTI--EWLQAG-----QP 4348
Query: 280 YTALFRTQTAPGGQGAPWAEELLAG 304
A R +T P G+ W E + G
Sbjct: 4349 LRASRRLRTLP--DGSLWLENVETG 4371
Score = 72.0 bits (175), Expect = 3e-12
Identities = 71/241 (29%), Positives = 98/241 (40%), Gaps = 36/241 (14%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
PQ+ +H Q F ++SC ASG P P I W Q L H+ GTL++
Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ--EDSRIHVDAQGTLII- 664
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAV-- 149
+G A + D G Y+C+A+N +GT +V + D P + AV
Sbjct: 665 ----QGVAPE------DAGNYSCQATNEVGTDQE-----TVTLYYTD----PPSVSAVNA 705
Query: 150 -----VGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
VGE+ L C G P P V W++ G + L P S G L + A++ D GT
Sbjct: 706 VVLVAVGEEAVLVCEAS-GVPPPRVIWYRGGLEMILAP--EGSSSGKLRIPAAQERDAGT 762
Query: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAV 264
Y C A N G + PQ P + V ++L LL A G P
Sbjct: 763 YTCRAVNELGDASAEIQLAVGHAPQLTELPRD---VTVELGRSALL-ACRATGRPPPTVT 818
Query: 265 W 265
W
Sbjct: 819 W 819
Score = 71.6 bits (174), Expect = 3e-12
Identities = 74/252 (29%), Positives = 100/252 (39%), Gaps = 31/252 (12%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP I P ++ + C ASG PPP + W QP+S + DG +L
Sbjct: 1885 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVT--VSVDGRVLR 1942
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLG-TAVSRGARLSVAVLREDFQIQPR-DMVA 148
++ QA +D G Y C ASN G T + G R++V + P
Sbjct: 1943 IE----------QAQLSDAGSYRCVASNVAGSTELRYGLRVNVP---PRITLPPSLPGPV 1989
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPL--ALQPGRHTVSGGSLL-MARAEKSDEGTY 205
+V L C G P PT+ W KDG P+ A PG GG +L +A A SD G Y
Sbjct: 1990 LVNTPVRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 2048
Query: 206 MCVATNSAGHRESRAARVSIQEPQDYTEPVELLAV---RIQLENVTLLNPDP-------A 255
CVA ++ G P E + + V + LE + P P
Sbjct: 2049 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDG 2108
Query: 256 EGPKPRPAVWLS 267
+PRP V LS
Sbjct: 2109 RPLEPRPGVHLS 2120
Score = 71.2 bits (173), Expect = 4e-12
Identities = 57/176 (32%), Positives = 82/176 (46%), Gaps = 30/176 (17%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
P + C A G P PT+ W G P++ + L DG++L L+ P G+A S
Sbjct: 1613 PVALECVARGHPSPTLSWHHEGLPVA--ESNESRLETDGSVLRLESP-------GEASS- 1662
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVA--------VVGEQFTLECG 159
G+Y+C AS+ G AV + SV V Q+ P+ +VA +VG+ L C
Sbjct: 1663 --GLYSCVASSPAGEAV---LQYSVEV-----QVPPQLLVAEGLGQVTTIVGQPLELPCQ 1712
Query: 160 PPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAG 214
G P PT+ W ++G+P G S G+ L + E G + C ATN AG
Sbjct: 1713 AS-GSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 1767
Score = 68.6 bits (166), Expect = 3e-11
Identities = 63/205 (30%), Positives = 94/205 (45%), Gaps = 33/205 (16%)
Query: 30 SPPQILVH-PQDQLFQGPGPARMSCQA-SGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGT 87
+PPQI P ++ +G P + C +G+P P WL +G+PL P H + DG+
Sbjct: 883 APPQIASSAPTVRVLEGQ-PVSLPCIVLAGRPLPERHWLKDGRPLP--PGSRHSIRADGS 939
Query: 88 LLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR--- 144
L H +AL G Y+C A+N G+ R L V Q+ PR
Sbjct: 940 L-----------HLDRALQEHAGRYSCVATNTAGSQ-HRDVELVV-------QVPPRIHP 980
Query: 145 ---DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSG-GSLLMARAEKS 200
+ G +L C G P PT++W K+ L + + VS G+LL+A+
Sbjct: 981 TATHHITNEGVPASLPCVAS-GVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQ 1039
Query: 201 DEGTYMCVATNSAGHRESRAARVSI 225
D G Y+C ATN+ G S+ R+S+
Sbjct: 1040 DAGAYVCTATNTVGF-SSQEMRLSV 1063
Score = 68.6 bits (166), Expect = 3e-11
Identities = 89/296 (30%), Positives = 121/296 (40%), Gaps = 38/296 (12%)
Query: 30 SPPQILVHPQDQLFQ---GPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDG 86
+PP I V P+ F PG + C +P P I W +G L D H
Sbjct: 3578 APPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQ---EDAH------ 3627
Query: 87 TLLLLQPPARGHAHDGQALST-DLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRD 145
Q P RG QALST D G Y+C A N G+ S R+ + + + P
Sbjct: 3628 ----TQFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTV-PTIRSGPPA 3681
Query: 146 MVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTV-SGGSLLMARAEKSDEGT 204
+ V + L C G P P VSW KD PL + R + GSL + D G
Sbjct: 3682 VNVSVNQTALLPCQAD-GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 3740
Query: 205 YMCVATNSAG-HRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Y+C+A+NSAG R+ R RV ++ P P L + LL + + PKP
Sbjct: 3741 YLCLASNSAGSDRQGRDLRV-LEPPAIAPSPSNL---TLTAHTPALLPCEASGSPKPLVV 3796
Query: 264 VW-----LSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLH 314
W L +++ A AL TAPG Q + E ++ S E+G H
Sbjct: 3797 WWKDGQKLDFRLQQGAYRLLPSNALL--LTAPGPQDSAQFECVV----SNEVGEAH 3846
Score = 57.4 bits (137), Expect = 7e-08
Identities = 61/261 (23%), Positives = 99/261 (37%), Gaps = 20/261 (7%)
Query: 29 DSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTL 88
D PPQ++ P + G A +SC+ G+ P + W+ + + +LP T
Sbjct: 515 DPPPQLVPAPNVTVSPGE-TAVLSCRVLGEAPYNLTWVRDWR-----------VLPASTG 562
Query: 89 LLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVA 148
+ Q G + TD G Y C ASN G V+R + + I
Sbjct: 563 RVAQLADLSLEISG-IIPTDGGRYQCVASNANG--VTRASVWLLVREAPQVSIHTSSQHF 619
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCV 208
G + + C G+P P +SW ++ + L H + G+L++ D G Y C
Sbjct: 620 SQGVEVKVSCSAS-GYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ 678
Query: 209 ATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSW 268
ATN G + + +P + ++ V + E V + A G P +W
Sbjct: 679 ATNEVG-TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCE---ASGVPPPRVIWYRG 734
Query: 269 KVSGPAAPAQSYTALFRTQTA 289
+ AP S + R A
Sbjct: 735 GLEMILAPEGSSSGKLRIPAA 755
Score = 57.0 bits (136), Expect = 9e-08
Identities = 48/184 (26%), Positives = 72/184 (39%), Gaps = 24/184 (13%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C+A G P P + W+ +G+PL L G L L+ G D G
Sbjct: 3426 LPCEARGVPLPLVSWMKDGEPLLS------QSLEQGPSLQLEAVGAG----------DSG 3469
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVS 170
Y+C A + G A + + QP ++ G L C G P+P ++
Sbjct: 3470 TYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ-GTPQPNIT 3528
Query: 171 WWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQD 230
W KDG+ L + S D G Y C+A + AG E ++ RV +Q P +
Sbjct: 3529 WHKDGQALT------RLENNSRATRVLRVRDAGLYTCLAESPAGAIE-KSFRVRVQAPPN 3581
Query: 231 YTEP 234
P
Sbjct: 3582 IVGP 3585
Score = 56.6 bits (135), Expect = 1e-07
Identities = 36/97 (37%), Positives = 44/97 (45%), Gaps = 13/97 (13%)
Query: 30 SPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLL 89
S P V PQD + + CQA+G+P PTI WL GQPL LPDG+L
Sbjct: 4307 SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLR--ASRRLRTLPDGSLW 4364
Query: 90 LLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSR 126
L + D G Y C A N LG+A +R
Sbjct: 4365 L-----------ENVETGDAGTYDCVAHNLLGSATAR 4390
Score = 30.8 bits (68), Expect = 6.7
Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 2/47 (4%)
Query: 184 RHTVSGG--SLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEP 228
RH G S + RA K++EGTY C A + AG ++A V P
Sbjct: 471 RHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPP 517
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 97.4 bits (241), Expect = 6e-20
Identities = 66/201 (32%), Positives = 94/201 (46%), Gaps = 27/201 (13%)
Query: 25 GMAQDSPPQILVHPQDQLFQGP----GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPH 80
G+ + PP+I + P GP P R++C A+G P PT+ WL +G P+S
Sbjct: 688 GLRVNVPPRITLPPS---LPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGL 744
Query: 81 HLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLG---TAVSRGARLSVAVLRE 137
+ P G +L L A ++D G Y+C A + +G V + ++L E
Sbjct: 745 QVFPGGRVLTL----------ASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGE 794
Query: 138 DFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMA-R 196
+ + V E LEC P P +SWWKDG+PL +PG H + +LL R
Sbjct: 795 ELNVS-----VVANESVALEC-QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDR 848
Query: 197 AEKSDEGTYMCVATNSAGHRE 217
A+ D G Y C A N AGH E
Sbjct: 849 ADVWDAGHYTCEALNQAGHSE 869
Score = 89.0 bits (219), Expect = 2e-17
Identities = 60/185 (32%), Positives = 83/185 (44%), Gaps = 20/185 (10%)
Query: 47 GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALS 106
G ++ C G P P I W+ +G PL H L +G+L + +
Sbjct: 2952 GSIQLDCVVRGDPVPDIHWIKDGLPLR--GSHLRHQLQNGSLTIRRTER----------- 2998
Query: 107 TDLGVYTCEASNRLGTAVSRGARLSVAVLRED--FQIQPRDMVAVVGEQFTLECGPPWGH 164
D G Y C A N +G A ++ + VL+ FQ++P+DM G+ L C G
Sbjct: 2999 DDAGRYQCLAENEMGVA----KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT-GE 3053
Query: 165 PEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVS 224
P PT+ W + G+PL T+ GSL + E D GTY CVA N G +RA V
Sbjct: 3054 PTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 3113
Query: 225 IQEPQ 229
EPQ
Sbjct: 3114 RGEPQ 3118
Score = 88.2 bits (217), Expect = 4e-17
Identities = 68/186 (36%), Positives = 92/186 (49%), Gaps = 16/186 (8%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
P R+SC+ G P P I W +GQPL H+ G LL L GQA
Sbjct: 897 PTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYL----------GQAQLA 946
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAVLRE-DFQIQPRDMVAVVGEQF-TLECGPPWGHP 165
G YTCE SN +G + S+ +L V V + +P V+VV + TLEC G P
Sbjct: 947 QEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKP 1004
Query: 166 EPTVSWWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVS 224
PTV+W +DG+P+ + G + G SL + RA+ + G Y CVA N AG R R +S
Sbjct: 1005 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELS 1063
Query: 225 IQEPQD 230
+ P +
Sbjct: 1064 VLVPPE 1069
Score = 86.3 bits (212), Expect = 1e-16
Identities = 60/174 (34%), Positives = 84/174 (48%), Gaps = 22/174 (12%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
P + C+A G PPP IRW +P+S P + +LL G +L + Q
Sbjct: 1087 PLTLLCEAMGIPPPAIRWFRGEEPVS--PGEDTYLLAGGWMLKMT----------QTQEQ 1134
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVV----GEQFTLECGPPWG 163
D G+Y+C ASN G A SV VL I+ D+ V+ G+ L C G
Sbjct: 1135 DSGLYSCLASNEAGEA---RRNFSVEVLVPP-SIENEDLEEVIKVLDGQTAHLMCNVT-G 1189
Query: 164 HPEPTVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGHR 216
HP+P ++W+KDG+PLA H G LL + +A S G Y C+A N+ G +
Sbjct: 1190 HPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 1243
Score = 85.1 bits (209), Expect = 3e-16
Identities = 80/255 (31%), Positives = 110/255 (43%), Gaps = 45/255 (17%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPH-HLLPDGTLLLLQPPARGHAHDGQALSTDL 109
+ C A G P PTI WL NG P S P P +L DG +L + A D
Sbjct: 1583 LQCPALGNPVPTISWLQNGLPFS---PSPRLQVLEDGQVLQV----------STAEVADA 1629
Query: 110 GVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTV 169
Y C A N+ G+A + L V V + + A++ +L C HP P V
Sbjct: 1630 ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPC-DVHAHPNPEV 1687
Query: 170 SWWKD------GKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARV 223
+W+KD G+ + L PG HT L + RA SD G Y C A N+AG R+ + ++
Sbjct: 1688 TWYKDSQALSLGEEVFLLPGTHT-----LQLGRARLSDSGMYTCEALNAAG-RDQKLVQL 1741
Query: 224 SIQEPQDYTE----PVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSG-PAAPAQ 278
S+ P + + P + + VR+ + V D P P V +W G P AQ
Sbjct: 1742 SVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL----PEPTV--TWYKDGQPLVLAQ 1795
Query: 279 SYTALFRTQTAPGGQ 293
RTQ GGQ
Sbjct: 1796 ------RTQALRGGQ 1804
Score = 83.2 bits (204), Expect = 1e-15
Identities = 89/302 (29%), Positives = 127/302 (42%), Gaps = 55/302 (18%)
Query: 50 RMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDL 109
++ C+A G P P I W +G LLP T ++ R G+A S+D
Sbjct: 239 QLLCEARGVPTPNITWFKDGA-----------LLPTSTKVVYTRGGR-QLQLGRAQSSDA 286
Query: 110 GVYTCEASNRLGTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHPEP 167
GVYTC+ASN +G A + RL V V E +P + AV G LEC GHP P
Sbjct: 287 GVYTCKASNAVG-AAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC-VARGHPSP 344
Query: 168 TVSWWKDGKPLALQPGRHTVSGGSLLMARAE-KSDEGTYMCVATNSAGHRESRAARVSIQ 226
T+SW +G P+A + GS+L + ++ G Y CVA++ AG + + V +Q
Sbjct: 345 TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYS-VEVQ 403
Query: 227 EPQDYTEPVELLAVRIQLENVTLLNPDPAEGP-----KPRPAV-WL-----SWKVSGPAA 275
P L V L VT + P E P P P + WL + +++G
Sbjct: 404 VPPQ-------LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQV 456
Query: 276 PAQ-----------SYTALFRTQTAPGGQGAPWAE-------ELLAGWQSAELGGLHWGQ 317
+Q ++ LF Q A G AE E G +G HWG
Sbjct: 457 ASQGTTLHIDHVELDHSGLFACQ-ATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGX 515
Query: 318 DY 319
++
Sbjct: 516 EH 517
Score = 80.9 bits (198), Expect = 6e-15
Identities = 81/239 (33%), Positives = 112/239 (46%), Gaps = 32/239 (13%)
Query: 50 RMSCQASGQPPPTIRWLLNGQPLSM-VPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTD 108
R+ C+A GQPPP + WL +G PL + P L G+L+L +G ++D
Sbjct: 1954 RLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVL-----KG------LRASD 2002
Query: 109 LGVYTCEASNRLGTAVSRGARL-SVAVLREDFQIQPRD----MVAVVGEQFTLECGPPWG 163
G YTC A N G ARL +V VL Q D +V+ GE T+ C P G
Sbjct: 2003 AGAYTCVAHNPAG----EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC-PVRG 2057
Query: 164 HPEPTVSWWKDGKPLALQPGRHTV---SGGSLLMARAEKSDEGTYMCVATNSAGHRESRA 220
P VSW KDG PL L + T+ SG +L +++ + +D G + CVA + AG + R
Sbjct: 2058 SPPIHVSWLKDGLPLPL--SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVAD-RN 2114
Query: 221 ARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQS 279
+ +Q P EPVE + + + P A G P P V SW G +QS
Sbjct: 2115 FTLQVQVP-PVLEPVEFQNDVVVVRGSLVELPCEARG-VPLPLV--SWMKDGEPLLSQS 2169
Score = 80.5 bits (197), Expect = 7e-15
Identities = 64/188 (34%), Positives = 89/188 (47%), Gaps = 19/188 (10%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C P P + W + Q LS+ + LLP L L G+A +D G
Sbjct: 1675 LPCDVHAHPNPEVTWYKDSQALSL--GEEVFLLPGTHTLQL----------GRARLSDSG 1722
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQIQ--PRDMVAV-VGEQFTLECGPPWGHPEP 167
+YTCEA N G + +LSV V Q P+D V V VG++ L C PEP
Sbjct: 1723 MYTCEALNAAGRD-QKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETD-ALPEP 1780
Query: 168 TVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGHRESRAARVSIQ 226
TV+W+KDG+PL L + GG L + A+ SD+G Y C +N AG R +++Q
Sbjct: 1781 TVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQ 1839
Query: 227 EPQDYTEP 234
P + P
Sbjct: 1840 VPPTFENP 1847
Score = 79.3 bits (194), Expect = 2e-14
Identities = 72/254 (28%), Positives = 116/254 (45%), Gaps = 38/254 (14%)
Query: 5 GDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGP------------GPARMS 52
G + L G+ ++G +QD ++ V PQ GP G A +
Sbjct: 941 GQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ---IAGPREPPTQVSVVQDGVATLE 997
Query: 53 CQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHA-HDGQALSTDLGV 111
C A+G+PPPT+ W +GQP+ G L LQ +G + H +A + G
Sbjct: 998 CNATGKPPPTVTWERDGQPV-------------GAELGLQLQNQGQSLHVERAQAAHTGR 1044
Query: 112 YTCEASNRLGTAVSRGARLSVAVLREDF-QIQP-RDMVAVVGEQFTLECGPPWGHPEPTV 169
Y+C A N G A R LSV V E + P ++ A + TL C G P P +
Sbjct: 1045 YSCVAENLAGRA-ERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLC-EAMGIPPPAI 1102
Query: 170 SWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGH-RESRAARVSIQ- 226
W++ +P++ + ++GG +L M + ++ D G Y C+A+N AG R + + V +
Sbjct: 1103 RWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPP 1162
Query: 227 --EPQDYTEPVELL 238
E +D E +++L
Sbjct: 1163 SIENEDLEEVIKVL 1176
Score = 79.3 bits (194), Expect = 2e-14
Identities = 65/235 (27%), Positives = 100/235 (42%), Gaps = 33/235 (14%)
Query: 17 LLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVP 76
LL I+GG + ++ V + P + C+A P P I W+ +G P
Sbjct: 1252 LLAPTILGGAEDSADEEVTVTVNN-------PISLICEALAFPSPNITWMKDGAPFEA-- 1302
Query: 77 PDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSR---GARLSVA 133
+ L P G A D G YTC +N LG AV + +
Sbjct: 1303 ---------SRNIQLLPGTHG-LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1352
Query: 134 VLRED--FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGS 191
+ ++D ++ +++ V TLEC W P PT+ W+KDG+P+ + G
Sbjct: 1353 ISKDDPLAEVGVKEVKTKVNSTLTLEC-ESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 1411
Query: 192 LLMAR-AEKSDEGTYMCVATNSAGHRESRAARVSIQEPQ------DYTEPVELLA 239
LL + + SD G Y+CVATN AG + + V IQ P D++ E+L+
Sbjct: 1412 LLQIQPTQVSDSGRYLCVATNVAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILS 1465
Score = 79.0 bits (193), Expect = 2e-14
Identities = 60/200 (30%), Positives = 84/200 (42%), Gaps = 20/200 (10%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP I D P ++C ++G P PT+ W G L + + P G L +
Sbjct: 2574 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG-ARGSGYRVSPSGALEI 2632
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMV--A 148
GQAL G YTC A N G A ++ ++P V A
Sbjct: 2633 -----------GQALPIHAGRYTCSARNSAGVAHKH----VFLTVQASPVVKPLPSVVRA 2677
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCV 208
V E+ L C G P PT++W K+G +A + GG L +A A D G Y+C+
Sbjct: 2678 VAEEEVLLPCEAS-GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCI 2736
Query: 209 ATNSAGHRESRAARVSIQEP 228
A NSAG + R+ +Q P
Sbjct: 2737 AKNSAGSAMGK-TRLVVQVP 2755
Score = 75.9 bits (185), Expect = 2e-13
Identities = 59/170 (34%), Positives = 78/170 (45%), Gaps = 17/170 (10%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C+ASG P PTI W G L++ +LP G L + AH A D G
Sbjct: 2685 LPCEASGIPRPTITWQKEG--LNVATGVSTQVLPGGQLRI--------AH---ASPEDAG 2731
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVS 170
Y C A N G+A+ + RL V V P D+ G L C G PEP ++
Sbjct: 2732 NYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLP-DLSTTEGSHAFLPCKAR-GSPEPNIT 2788
Query: 171 WWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEGTYMCVATNSAGHRESR 219
W KDG+P++ G+ T+ G LL+ E D GTY C A N+ G R
Sbjct: 2789 WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRR 2838
Score = 74.7 bits (182), Expect = 4e-13
Identities = 60/177 (33%), Positives = 81/177 (45%), Gaps = 16/177 (9%)
Query: 38 PQDQLFQGPGP-ARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPAR 96
PQD + G A +SC+ P PT+ W +GQPL V L G L +Q
Sbjct: 1756 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPL--VLAQRTQALRGGQRLEIQ---- 1809
Query: 97 GHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTL 156
+A +D G+Y+C+ SN G AV R L+V V + + V G L
Sbjct: 1810 ------EAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVL 1862
Query: 157 ECGPPWGHPEPTVSWWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEGTYMCVATNS 212
C G P PTV+W KD P+ VS GG L ++R + + GTY CVA N+
Sbjct: 1863 TCDVS-GVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENT 1918
Score = 74.3 bits (181), Expect = 5e-13
Identities = 80/270 (29%), Positives = 109/270 (40%), Gaps = 38/270 (14%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSM-VPPDPHHLLPDGTLL 89
PP I P + PA + C+ASG P P + W +GQ L + + LLP LL
Sbjct: 2481 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2540
Query: 90 LLQPPARGHAHDGQALSTDLGVYTCEASNRLGTA-----VSRGARLSVAVLREDFQIQPR 144
L P + D + C SN +G A V+ ++A + DF +
Sbjct: 2541 LTAPGPQ-----------DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTV--- 2586
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEG 203
M+A V L C G P PTVSW K G L + + VS G+L + +A G
Sbjct: 2587 TMMAPV----VLTCHST-GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAG 2641
Query: 204 TYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Y C A NSAG P +P+ + + E V L P A G PRP
Sbjct: 2642 RYTCSARNSAGVAHKHVFLTVQASP--VVKPLPSVVRAVAEEEVLL--PCEASG-IPRPT 2696
Query: 264 VWLSWKVSGPAAPAQSYTALFRTQTAPGGQ 293
+ +W+ G + TQ PGGQ
Sbjct: 2697 I--TWQKEG-----LNVATGVSTQVLPGGQ 2719
Score = 74.3 bits (181), Expect = 5e-13
Identities = 64/211 (30%), Positives = 93/211 (44%), Gaps = 22/211 (10%)
Query: 49 ARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTD 108
A + C+A G P P I W +GQP+S + P G LL+ +GQ D
Sbjct: 2773 AFLPCKARGSPEPNITWDKDGQPVSGA-EGKFTIQPSGELLVKN-------LEGQ----D 2820
Query: 109 LGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPT 168
G YTC A N +G A R L++ VL F P D +G++ L C G P P
Sbjct: 2821 AGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDRLWLRCAAR-GSPTPR 2877
Query: 169 VSWWKDGKPLALQPGRHTVSGGSLLM-ARAEKSDEGTYMCVATNSAGHRES----RAARV 223
+ W + +P+ G GGS L A + D GTY+C A N G ++
Sbjct: 2878 IGWTVNDRPVT--EGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 2935
Query: 224 SIQEPQDYTEPVELLAVRIQLENVTLLNPDP 254
+ + + ++ VE + IQL+ V +P P
Sbjct: 2936 PVLQGEAFSYLVEPVGGSIQLDCVVRGDPVP 2966
Score = 73.6 bits (179), Expect = 9e-13
Identities = 53/173 (30%), Positives = 82/173 (47%), Gaps = 16/173 (9%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
PA + C + PPP + W QPLS D +L G +L + P R +
Sbjct: 1485 PAYLYCDTNAIPPPDLTWYREDQPLS--AGDEVSVLQGGRVLQI-PLVR---------AE 1532
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVA--VLREDFQIQPRDMVAVVGEQFTLECGPPWGHP 165
+ G Y+C+ASN +G L + V+ D + ++ +L+C P G+P
Sbjct: 1533 NAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-PALGNP 1591
Query: 166 EPTVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGHRE 217
PT+SW ++G P + P + G +L ++ AE +D +YMCVA N AG E
Sbjct: 1592 VPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE 1644
Score = 73.6 bits (179), Expect = 9e-13
Identities = 66/195 (33%), Positives = 85/195 (43%), Gaps = 30/195 (15%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHD---GQALST 107
M C G PP + WL +G PL L TLL G H +
Sbjct: 2051 MVCPVRGSPPIHVSWLKDGLPLP---------LSQRTLL------HGSGHTLRISKVQLA 2095
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHP 165
D G++TC A++ G A R L V V + E + Q D+V V G L C G P
Sbjct: 2096 DAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQ-NDVVVVRGSLVELPCEAR-GVP 2152
Query: 166 EPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSI 225
P VSW KDG+PL Q G SL + D GTY CVA + AG R ++++
Sbjct: 2153 LPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR-RHFQLTV 2208
Query: 226 QEP---QDYTEPVEL 237
EP +D +P EL
Sbjct: 2209 MEPPHIEDSGQPTEL 2223
Score = 72.8 bits (177), Expect = 2e-12
Identities = 76/256 (29%), Positives = 104/256 (40%), Gaps = 44/256 (17%)
Query: 31 PPQILVHP---QDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGT 87
PPQ+LV Q G P + CQASG P PTI+WL NG+P + + GT
Sbjct: 405 PPQLLVAEGLGQVTTIVGQ-PLELPCQASGSPVPTIQWLQNGRPAEELA--GVQVASQGT 461
Query: 88 LLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMV 147
L + H+ G++ C+A+N GTA GA + V+V E P +
Sbjct: 462 TLHIDHVELDHS----------GLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLE 505
Query: 148 AVVGE---------QFTLECGPP----WG-HPE-PTVSWWKDGKPLALQPGRHTVSGG-- 190
+G+ F C PP WG HP+ P V W L +P V+
Sbjct: 506 VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 565
Query: 191 -SLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTL 249
L + + + DEG Y C ATN AG + A + P PV + LEN ++
Sbjct: 566 PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVN----KAVLENASV 621
Query: 250 LNPDPAEGPKPRPAVW 265
A G P W
Sbjct: 622 TLECLASGVPPPDVSW 637
Score = 72.8 bits (177), Expect = 2e-12
Identities = 77/265 (29%), Positives = 108/265 (40%), Gaps = 52/265 (19%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST-DL 109
+ C A G P P I W +N +P++ + DG G A+S D
Sbjct: 2866 LRCAARGSPTPRIGWTVNDRPVTEGVSEQ-----DG----------GSTLQRAAVSREDS 2910
Query: 110 GVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRD---MVAVVGEQFTLECGPPWGHPE 166
G Y C A NR+G R +S ++E +Q +V VG L+C G P
Sbjct: 2911 GTYVCWAENRVG----RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR-GDPV 2965
Query: 167 PTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRES------RA 220
P + W KDG PL RH + GSL + R E+ D G Y C+A N G + ++
Sbjct: 2966 PDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQS 3025
Query: 221 ARVSIQEPQDYT-EPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQS 279
A V EPQD T + +A+R Q +P P + W +G Q
Sbjct: 3026 APVFQVEPQDMTVRSGDDVALRCQATG------------EPTPTI--EWLQAG-----QP 3066
Query: 280 YTALFRTQTAPGGQGAPWAEELLAG 304
A R +T P G+ W E + G
Sbjct: 3067 LRASRRLRTLP--DGSLWLENVETG 3089
Score = 71.6 bits (174), Expect = 3e-12
Identities = 74/252 (29%), Positives = 100/252 (39%), Gaps = 31/252 (12%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP I P ++ + C ASG PPP + W QP+S + DG +L
Sbjct: 603 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVT--VSVDGRVLR 660
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLG-TAVSRGARLSVAVLREDFQIQPR-DMVA 148
++ QA +D G Y C ASN G T + G R++V + P
Sbjct: 661 IE----------QAQLSDAGSYRCVASNVAGSTELRYGLRVNVP---PRITLPPSLPGPV 707
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPL--ALQPGRHTVSGGSLL-MARAEKSDEGTY 205
+V L C G P PT+ W KDG P+ A PG GG +L +A A SD G Y
Sbjct: 708 LVNTPVRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 766
Query: 206 MCVATNSAGHRESRAARVSIQEPQDYTEPVELLAV---RIQLENVTLLNPDP-------A 255
CVA ++ G P E + + V + LE + P P
Sbjct: 767 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDG 826
Query: 256 EGPKPRPAVWLS 267
+PRP V LS
Sbjct: 827 RPLEPRPGVHLS 838
Score = 71.2 bits (173), Expect = 4e-12
Identities = 57/176 (32%), Positives = 82/176 (46%), Gaps = 30/176 (17%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
P + C A G P PT+ W G P++ + L DG++L L+ P G+A S
Sbjct: 331 PVALECVARGHPSPTLSWHHEGLPVA--ESNESRLETDGSVLRLESP-------GEASS- 380
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVA--------VVGEQFTLECG 159
G+Y+C AS+ G AV + SV V Q+ P+ +VA +VG+ L C
Sbjct: 381 --GLYSCVASSPAGEAV---LQYSVEV-----QVPPQLLVAEGLGQVTTIVGQPLELPCQ 430
Query: 160 PPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAG 214
G P PT+ W ++G+P G S G+ L + E G + C ATN AG
Sbjct: 431 AS-GSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 485
Score = 68.6 bits (166), Expect = 3e-11
Identities = 89/296 (30%), Positives = 121/296 (40%), Gaps = 38/296 (12%)
Query: 30 SPPQILVHPQDQLFQ---GPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDG 86
+PP I V P+ F PG + C +P P I W +G L D H
Sbjct: 2296 APPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQ---EDAH------ 2345
Query: 87 TLLLLQPPARGHAHDGQALST-DLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRD 145
Q P RG QALST D G Y+C A N G+ S R+ + + + P
Sbjct: 2346 ----TQFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTV-PTIRSGPPA 2399
Query: 146 MVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTV-SGGSLLMARAEKSDEGT 204
+ V + L C G P P VSW KD PL + R + GSL + D G
Sbjct: 2400 VNVSVNQTALLPCQAD-GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2458
Query: 205 YMCVATNSAG-HRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Y+C+A+NSAG R+ R RV ++ P P L + LL + + PKP
Sbjct: 2459 YLCLASNSAGSDRQGRDLRV-LEPPAIAPSPSNL---TLTAHTPALLPCEASGSPKPLVV 2514
Query: 264 VW-----LSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLH 314
W L +++ A AL TAPG Q + E ++ S E+G H
Sbjct: 2515 WWKDGQKLDFRLQQGAYRLLPSNALL--LTAPGPQDSAQFECVV----SNEVGEAH 2564
Score = 63.2 bits (152), Expect = 1e-09
Identities = 60/206 (29%), Positives = 89/206 (43%), Gaps = 24/206 (11%)
Query: 30 SPPQILVH--PQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPH-HLLPDG 86
+PP +L Q+ L + C SG P P + W + QP ++P PH + DG
Sbjct: 123 TPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQP--VLPGGPHLQVQEDG 180
Query: 87 TLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDM 146
+L + +H G D G Y C A + G +R +L V +
Sbjct: 181 QVLRIT-----GSHVG-----DEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGE 229
Query: 147 VAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR----HTVSGGSLLMARAEKSDE 202
VAV+ + G P P ++W+KDG AL P +T G L + RA+ SD
Sbjct: 230 VAVMEDHLVQLLCEARGVPTPNITWFKDG---ALLPTSTKVVYTRGGRQLQLGRAQSSDA 286
Query: 203 GTYMCVATNSAGHRESRAARVSIQEP 228
G Y C A+N+ G E +A R+ + P
Sbjct: 287 GVYTCKASNAVGAAE-KATRLDVYVP 311
Score = 58.5 bits (140), Expect = 3e-08
Identities = 67/249 (26%), Positives = 100/249 (40%), Gaps = 41/249 (16%)
Query: 51 MSCQASGQPPPTIRWL----LNGQPLSMV---------PPDPHHLLPDGTLLLLQPPARG 97
+ C A+G P P I WL L G PL H LL +G L
Sbjct: 38 LECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSL-------- 89
Query: 98 HAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSV----AVLREDFQIQPRDMVAVVGEQ 153
H + D G+Y+C A N+ GTA R L V +VL ++++ + G
Sbjct: 90 --HFPRIQEGDSGLYSCRAENQAGTA-QRDFHLLVLTPPSVLGAG---AAQEVLGLAGAD 143
Query: 154 FTLECGPPWGHPEPTVSWWKDGKPLALQPGRH---TVSGGSLLMARAEKSDEGTYMCVAT 210
L+C G P P V W KD +P+ L G H G L + + DEG Y CVA
Sbjct: 144 VELQCWTS-GVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF 201
Query: 211 NSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKV 270
+ AG +++R ++ + P E V + +++ L + P P ++W
Sbjct: 202 SPAG-QQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN----ITWFK 256
Query: 271 SGPAAPAQS 279
G P +
Sbjct: 257 DGALLPTST 265
Score = 57.0 bits (136), Expect = 9e-08
Identities = 48/184 (26%), Positives = 72/184 (39%), Gaps = 24/184 (13%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C+A G P P + W+ +G+PL L G L L+ G D G
Sbjct: 2144 LPCEARGVPLPLVSWMKDGEPLLS------QSLEQGPSLQLEAVGAG----------DSG 2187
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVS 170
Y+C A + G A + + QP ++ G L C G P+P ++
Sbjct: 2188 TYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ-GTPQPNIT 2246
Query: 171 WWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQD 230
W KDG+ L + S D G Y C+A + AG E ++ RV +Q P +
Sbjct: 2247 WHKDGQALT------RLENNSRATRVLRVRDAGLYTCLAESPAGAIE-KSFRVRVQAPPN 2299
Query: 231 YTEP 234
P
Sbjct: 2300 IVGP 2303
Score = 56.6 bits (135), Expect = 1e-07
Identities = 36/97 (37%), Positives = 44/97 (45%), Gaps = 13/97 (13%)
Query: 30 SPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLL 89
S P V PQD + + CQA+G+P PTI WL GQPL LPDG+L
Sbjct: 3025 SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLR--ASRRLRTLPDGSLW 3082
Query: 90 LLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSR 126
L + D G Y C A N LG+A +R
Sbjct: 3083 L-----------ENVETGDAGTYDCVAHNLLGSATAR 3108
Score = 39.3 bits (90), Expect = 0.019
Identities = 32/96 (33%), Positives = 42/96 (43%), Gaps = 19/96 (19%)
Query: 135 LREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKD----GKPLAL---------- 180
+RED + ++ + G+ TLEC G P P + W KD G PL
Sbjct: 19 IREDGR--KANVSGMAGQSLTLECDAN-GFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75
Query: 181 QPGRHTV--SGGSLLMARAEKSDEGTYMCVATNSAG 214
Q G H + G SL R ++ D G Y C A N AG
Sbjct: 76 QVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG 111
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 97.1 bits (240), Expect = 8e-20
Identities = 105/424 (24%), Positives = 165/424 (38%), Gaps = 59/424 (13%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P I + PQ ++ + A M C ASG P P I W + +P DP +G + L
Sbjct: 135 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKD-----FLPVDPS--ASNGRIKQL 187
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLR--EDFQIQPRDMVAV 149
+ G + TD G Y C A+N G S A L V V R F I P +
Sbjct: 188 RS---GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIM 244
Query: 150 VGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVA 209
G + C G P P V W + + L + G ++ + D Y CVA
Sbjct: 245 PGGNVNITCVAV-GSPMPYVKWMQGAEDLTPEDDMPV---GRNVLELTDVKDSANYTCVA 300
Query: 210 TNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWK 269
+S G E+ A +I ++++ P ++ ++W
Sbjct: 301 MSSLGVIEAVA--------------------QITVKSLPKAPGTPMVTENTATSITITWD 340
Query: 270 VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKVRPSSGR 329
SG P Y +++++ G P+ + +GGL +YE V +
Sbjct: 341 -SGNPDPVSYYVIEYKSKSQDG----PYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSI 395
Query: 330 ARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGIIRGYQVWSLGN 389
+GP S ++ R E+ P++ P+ V + + T + P E NG+IRGY+V+
Sbjct: 396 GQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVE-PNGLIRGYRVYYTME 454
Query: 390 TSLPPANW----------TVVGEQTQLEIATHMPGSYCVQVAAVTGAGAGEPSRPVCLLL 439
P NW T VG + E +Y V+V A T G G S P+ +
Sbjct: 455 PEHPVGNWQKHNVDDSLLTTVGSLLEDE-------TYTVRVLAFTSVGDGPLSDPIQVKT 507
Query: 440 EQAM 443
+Q +
Sbjct: 508 QQGV 511
Score = 95.5 bits (236), Expect = 2e-19
Identities = 71/238 (29%), Positives = 111/238 (46%), Gaps = 33/238 (13%)
Query: 5 GDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIR 64
G ++ G + LL++L++GG A + PP+ + P+DQ+ G A CQA+G P P +
Sbjct: 6 GPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVT 65
Query: 65 W-----LLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNR 119
W +N Q + D G +L +QP D VY C A N
Sbjct: 66 WNKKGKKVNSQRFETIEFDE----SAGAVLRIQP---------LRTPRDENVYECVAQNS 112
Query: 120 LGTAVSRGARLSVAVLRED--------FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW 171
+G + VLRED + P+ V T+ C G+P+P ++W
Sbjct: 113 VGEIT---VHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS-GNPDPEITW 168
Query: 172 WKDGKPL--ALQPGR-HTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQ 226
+KD P+ + GR + G+L + +E++D+G Y CVATNSAG R S A + ++
Sbjct: 169 FKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR 226
Score = 55.5 bits (132), Expect = 3e-07
Identities = 45/156 (28%), Positives = 64/156 (41%), Gaps = 5/156 (3%)
Query: 318 DYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGT-VFVSWVPPPAENHN 376
+Y F++ S + G + V+ R + PSAPPQ+V T + VSW PPP E HN
Sbjct: 576 EYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHN 635
Query: 377 GIIRGYQV--WSLGNTSLPPANWTVVGEQTQ--LEIATHMPGSYCVQVAAVTGAGAGEPS 432
G + GY V LG+ P + T L A Y + A T G G S
Sbjct: 636 GALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPES 695
Query: 433 RPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468
PV + ++ + A E +R + P
Sbjct: 696 SPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSP 731
Score = 53.5 bits (127), Expect = 1e-06
Identities = 39/119 (32%), Positives = 60/119 (50%), Gaps = 7/119 (5%)
Query: 332 GPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVF-VSWVPPPAENHNGIIRGYQVWSL--- 387
GP+S+ +++R E VPSAPP++V + N T V W P +G IRGYQV +
Sbjct: 692 GPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRME 751
Query: 388 -GNTSLPPANWTVVGEQTQLEIATHM--PGSYCVQVAAVTGAGAGEPSRPVCLLLEQAM 443
PP V+ Q + T++ +Y + VAA T G G S+P ++ + A+
Sbjct: 752 GAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAV 810
Score = 47.8 bits (112), Expect = 5e-05
Identities = 42/133 (31%), Positives = 57/133 (42%), Gaps = 10/133 (7%)
Query: 312 GLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ--EVTLKPGNGTVFVSWVP 369
G+H G Y F++ S G ++ +L +PE P PQ E GTV + W+P
Sbjct: 872 GVHKGATYVFRLAARSRGGLGEEA-AEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLP 930
Query: 370 PPAENHNGIIRGYQVWSLGNTSLPPANWTVV------GEQTQLEIATHMPG-SYCVQVAA 422
P NG I Y V +L PA T + G + L + P +Y +QV A
Sbjct: 931 PVPAERNGAIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRA 990
Query: 423 VTGAGAGEPSRPV 435
T G G S PV
Sbjct: 991 HTRRGPGPFSPPV 1003
Score = 40.0 bits (92), Expect = 0.011
Identities = 29/93 (31%), Positives = 43/93 (46%), Gaps = 6/93 (6%)
Query: 142 QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR---HTVSGGSLLMARAE 198
+P+D + V G + C G P+P V+W K GK + Q S G++L +
Sbjct: 38 EPKDQIGVSGGVASFVCQAT-GDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPL 96
Query: 199 KS--DEGTYMCVATNSAGHRESRAARVSIQEPQ 229
++ DE Y CVA NS G A ++E Q
Sbjct: 97 RTPRDENVYECVAQNSVGEITVHAKLTVLREDQ 129
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 97.1 bits (240), Expect = 8e-20
Identities = 105/424 (24%), Positives = 165/424 (38%), Gaps = 59/424 (13%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P I + PQ ++ + A M C ASG P P I W + +P DP +G + L
Sbjct: 135 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKD-----FLPVDPS--ASNGRIKQL 187
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLR--EDFQIQPRDMVAV 149
+ G + TD G Y C A+N G S A L V V R F I P +
Sbjct: 188 RS---GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIM 244
Query: 150 VGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVA 209
G + C G P P V W + + L + G ++ + D Y CVA
Sbjct: 245 PGGNVNITCVAV-GSPMPYVKWMQGAEDLTPEDDMPV---GRNVLELTDVKDSANYTCVA 300
Query: 210 TNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWK 269
+S G E+ A +I ++++ P ++ ++W
Sbjct: 301 MSSLGVIEAVA--------------------QITVKSLPKAPGTPMVTENTATSITITWD 340
Query: 270 VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKVRPSSGR 329
SG P Y +++++ G P+ + +GGL +YE V +
Sbjct: 341 -SGNPDPVSYYVIEYKSKSQDG----PYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSI 395
Query: 330 ARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGIIRGYQVWSLGN 389
+GP S ++ R E+ P++ P+ V + + T + P E NG+IRGY+V+
Sbjct: 396 GQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVE-PNGLIRGYRVYYTME 454
Query: 390 TSLPPANW----------TVVGEQTQLEIATHMPGSYCVQVAAVTGAGAGEPSRPVCLLL 439
P NW T VG + E +Y V+V A T G G S P+ +
Sbjct: 455 PEHPVGNWQKHNVDDSLLTTVGSLLEDE-------TYTVRVLAFTSVGDGPLSDPIQVKT 507
Query: 440 EQAM 443
+Q +
Sbjct: 508 QQGV 511
Score = 95.5 bits (236), Expect = 2e-19
Identities = 71/238 (29%), Positives = 111/238 (46%), Gaps = 33/238 (13%)
Query: 5 GDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIR 64
G ++ G + LL++L++GG A + PP+ + P+DQ+ G A CQA+G P P +
Sbjct: 6 GPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVT 65
Query: 65 W-----LLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNR 119
W +N Q + D G +L +QP D VY C A N
Sbjct: 66 WNKKGKKVNSQRFETIEFDE----SAGAVLRIQP---------LRTPRDENVYECVAQNS 112
Query: 120 LGTAVSRGARLSVAVLRED--------FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW 171
+G + VLRED + P+ V T+ C G+P+P ++W
Sbjct: 113 VGEIT---VHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS-GNPDPEITW 168
Query: 172 WKDGKPL--ALQPGR-HTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQ 226
+KD P+ + GR + G+L + +E++D+G Y CVATNSAG R S A + ++
Sbjct: 169 FKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR 226
Score = 40.0 bits (92), Expect = 0.011
Identities = 29/93 (31%), Positives = 43/93 (46%), Gaps = 6/93 (6%)
Query: 142 QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR---HTVSGGSLLMARAE 198
+P+D + V G + C G P+P V+W K GK + Q S G++L +
Sbjct: 38 EPKDQIGVSGGVASFVCQAT-GDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPL 96
Query: 199 KS--DEGTYMCVATNSAGHRESRAARVSIQEPQ 229
++ DE Y CVA NS G A ++E Q
Sbjct: 97 RTPRDENVYECVAQNSVGEITVHAKLTVLREDQ 129
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 96.3 bits (238), Expect = 1e-19
Identities = 70/222 (31%), Positives = 112/222 (50%), Gaps = 24/222 (10%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P L P++ + R+ C+A+G P PT++W++NG+PL PP+P+ + T++
Sbjct: 348 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF- 406
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLR-EDFQIQPRDMV--A 148
D Q S VY C SN G + A V+VL + PR+ +
Sbjct: 407 --------RDTQISSR--AVYQCNTSNEHGYLL---ANAFVSVLDVPPRMLSPRNQLIRV 453
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMARAEKSDEGTYMC 207
++ + L+C P +G P PT+ W+K+G+ L G H GSL + K D+G Y C
Sbjct: 454 ILYNRTRLDC-PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 512
Query: 208 VATNSAGHRESRAARVSIQEP-QDYTEPVELLAVR---IQLE 245
VATN G E++ R+ +++P + Y P + +A R +QLE
Sbjct: 513 VATNILGKAENQ-VRLEVKDPTRIYRMPEDQVARRGTTVQLE 553
Score = 70.1 bits (170), Expect = 1e-11
Identities = 68/233 (29%), Positives = 104/233 (44%), Gaps = 20/233 (8%)
Query: 29 DSPPQILVHPQDQLFQGP--GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDG 86
D PP++L P++QL + R+ C G P PT+RW NGQ S + +H+ +G
Sbjct: 438 DVPPRML-SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG-SNLDGGNYHVYENG 495
Query: 87 TLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDM 146
+L + D G+YTC A+N LG A ++ RL V +++ P D
Sbjct: 496 SLEIKM-----------IRKEDQGIYTCVATNILGKAENQ-VRLEVKDPTRIYRM-PEDQ 542
Query: 147 VAVVGEQFTLECGPPWGHP-EPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTY 205
VA G LEC + TVSW KD +PL + R SL + + D+G+Y
Sbjct: 543 VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKKEDDSLTIFGVAERDQGSY 601
Query: 206 MCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGP 258
CVA+ ++A + P D +EL + + +T + D P
Sbjct: 602 TCVASTELDQDLAKAYLTVLGRP-DRPRDLELTDLAERSVRLTWIPGDANNSP 653
Score = 61.2 bits (147), Expect = 5e-09
Identities = 58/204 (28%), Positives = 86/204 (42%), Gaps = 26/204 (12%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C ASG P P I W G L P D L + D G
Sbjct: 277 LECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNKALRIT----------NVSEEDSG 323
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQI-QPRDMVAVVGEQFTLECGPPWGHPEPTV 169
Y C ASN++G S +SV V + + +P++++ GE L C G+P+PTV
Sbjct: 324 EYFCLASNKMG---SIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN-GNPKPTV 379
Query: 170 SWWKDGKPLALQP--GRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQE 227
W +G+PL P V+G +++ + S Y C +N G+ + A VS+ +
Sbjct: 380 QWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAF-VSVLD 438
Query: 228 PQDYTEPVELLAVRIQLENVTLLN 251
P +L+ R QL V L N
Sbjct: 439 -----VPPRMLSPRNQLIRVILYN 457
Score = 57.8 bits (138), Expect = 5e-08
Identities = 51/173 (29%), Positives = 75/173 (43%), Gaps = 36/173 (20%)
Query: 17 LLLLLIMGG-----MAQDSPPQI--------LVHPQDQLFQGPGPARMSCQASGQPPPTI 63
LL LL +GG M PP I +V P+D + + C+A G P P+
Sbjct: 15 LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNIL-------IECEAKGNPAPSF 67
Query: 64 RWLLNGQPLSMVPPDPHHLLP--DGTLLL-LQPPARGHAHDGQALSTDLGVYTCEASNRL 120
W N + + + DP + GTL++ + R ++G+ Y C A N+
Sbjct: 68 HWTRNSRFFN-IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE--------YQCFARNKF 118
Query: 121 GTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW 171
GTA+S RL V+ L + P +V G TL+C PP G P P + W
Sbjct: 119 GTALSNRIRLQVSKSPLWPKENLDP--VVVQEGAPLTLQCNPPPGLPSPVIFW 169
Score = 45.4 bits (106), Expect = 3e-04
Identities = 59/221 (26%), Positives = 88/221 (39%), Gaps = 46/221 (20%)
Query: 318 DYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNG 377
+Y+ ++ +GR GP S PE VPSAP + +P T+ + W P E+ NG
Sbjct: 899 NYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHP--EHPNG 956
Query: 378 IIRGYQVWSLGNTSLPPANWTVVGE---------QTQLEIATHMPGS-YCVQVAAVTGAG 427
I+ GY + N T VG+ QT+ + P S Y ++A T G
Sbjct: 957 IMIGYTL------KYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVG 1010
Query: 428 AGEPSRPVCLLLEQAMERATQEPSEHGP---WTLEQLRATLKRPEVIATCGVALWLLLLG 484
+G E E + P+E P +T Q + + C +AL +L+L
Sbjct: 1011 SG----------EAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILL 1060
Query: 485 TAVCIHR--------RRRARVHLGP-------GLYRYTSED 510
I R R + V LGP G + Y+ ED
Sbjct: 1061 IVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDED 1101
Score = 37.7 bits (86), Expect = 0.055
Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 151 GEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVAT 210
G LEC G P P ++W+K G L + +L + + D G Y C+A+
Sbjct: 272 GMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLAS 330
Query: 211 NSAGH-RESRAARVSIQEPQDYTEPVELL 238
N G R + + RV P EP L+
Sbjct: 331 NKMGSIRHTISVRVK-AAPYWLDEPKNLI 358
Score = 37.7 bits (86), Expect = 0.055
Identities = 87/426 (20%), Positives = 149/426 (34%), Gaps = 65/426 (15%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPP--TIRWLLNGQPLSMVPPDPHHLLPDGTL 88
P +I P+DQ+ + ++ C+ P T+ WL + +PL + D +L
Sbjct: 532 PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI---GNRMKKEDDSL 588
Query: 89 LLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVA 148
+ R D G YTC AS L + A+ + VL + + ++
Sbjct: 589 TIFGVAER-----------DQGSYTCVASTELDQDL---AKAYLTVLGRPDRPRDLELTD 634
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPG---RHTVSGGSLLMARAEKSDEGTY 205
+ L P + P + + QPG H+ GS+ A S Y
Sbjct: 635 LAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNY 694
Query: 206 M--CVATNSAGHRE----SRAARVSIQEPQDYTEPVELLAVRIQLENVTL--LNPDPAEG 257
+A N G S R S P+ V+ R +T +N A G
Sbjct: 695 QFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFG 754
Query: 258 PKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAP-WAEELLAGWQSAELGGLHWG 316
P R V W+ R +T W + G +
Sbjct: 755 PNLRYIV--KWR---------------RRETREAWNNVTVWGSRYVVGQTPVYV------ 791
Query: 317 QDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGT-VFVSWVPPPAENH 375
YE +V+ + +GP+ ++ E P A P EV ++ N T + + W ++
Sbjct: 792 -PYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTV 850
Query: 376 NGIIRGYQVWSLGNTSLPPANW--------TVVGEQTQLEIATHMP-GSYCVQVAAVTGA 426
G +R Y+ + +SL W + G++ + ++ P +Y +++ V G
Sbjct: 851 QGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGR 910
Query: 427 GAGEPS 432
G G S
Sbjct: 911 GDGPRS 916
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 96.3 bits (238), Expect = 1e-19
Identities = 70/222 (31%), Positives = 112/222 (50%), Gaps = 24/222 (10%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P L P++ + R+ C+A+G P PT++W++NG+PL PP+P+ + T++
Sbjct: 348 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF- 406
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLR-EDFQIQPRDMV--A 148
D Q S VY C SN G + A V+VL + PR+ +
Sbjct: 407 --------RDTQISSR--AVYQCNTSNEHGYLL---ANAFVSVLDVPPRMLSPRNQLIRV 453
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMARAEKSDEGTYMC 207
++ + L+C P +G P PT+ W+K+G+ L G H GSL + K D+G Y C
Sbjct: 454 ILYNRTRLDC-PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 512
Query: 208 VATNSAGHRESRAARVSIQEP-QDYTEPVELLAVR---IQLE 245
VATN G E++ R+ +++P + Y P + +A R +QLE
Sbjct: 513 VATNILGKAENQ-VRLEVKDPTRIYRMPEDQVARRGTTVQLE 553
Score = 68.6 bits (166), Expect = 3e-11
Identities = 60/185 (32%), Positives = 88/185 (47%), Gaps = 19/185 (10%)
Query: 29 DSPPQILVHPQDQLFQGP--GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDG 86
D PP++L P++QL + R+ C G P PT+RW NGQ S + +H+ +G
Sbjct: 438 DVPPRML-SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG-SNLDGGNYHVYENG 495
Query: 87 TLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDM 146
+L + D G+YTC A+N LG A ++ RL V +++ P D
Sbjct: 496 SLEIKM-----------IRKEDQGIYTCVATNILGKAENQ-VRLEVKDPTRIYRM-PEDQ 542
Query: 147 VAVVGEQFTLECGPPWGHP-EPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTY 205
VA G LEC + TVSW KD +PL + R SL + + D+G+Y
Sbjct: 543 VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKKEDDSLTIFGVAERDQGSY 601
Query: 206 MCVAT 210
CVA+
Sbjct: 602 TCVAS 606
Score = 61.2 bits (147), Expect = 5e-09
Identities = 58/204 (28%), Positives = 86/204 (42%), Gaps = 26/204 (12%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C ASG P P I W G L P D L + D G
Sbjct: 277 LECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNKALRIT----------NVSEEDSG 323
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQI-QPRDMVAVVGEQFTLECGPPWGHPEPTV 169
Y C ASN++G S +SV V + + +P++++ GE L C G+P+PTV
Sbjct: 324 EYFCLASNKMG---SIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN-GNPKPTV 379
Query: 170 SWWKDGKPLALQP--GRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQE 227
W +G+PL P V+G +++ + S Y C +N G+ + A VS+ +
Sbjct: 380 QWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAF-VSVLD 438
Query: 228 PQDYTEPVELLAVRIQLENVTLLN 251
P +L+ R QL V L N
Sbjct: 439 -----VPPRMLSPRNQLIRVILYN 457
Score = 57.8 bits (138), Expect = 5e-08
Identities = 51/173 (29%), Positives = 75/173 (43%), Gaps = 36/173 (20%)
Query: 17 LLLLLIMGG-----MAQDSPPQI--------LVHPQDQLFQGPGPARMSCQASGQPPPTI 63
LL LL +GG M PP I +V P+D + + C+A G P P+
Sbjct: 15 LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNIL-------IECEAKGNPAPSF 67
Query: 64 RWLLNGQPLSMVPPDPHHLLP--DGTLLL-LQPPARGHAHDGQALSTDLGVYTCEASNRL 120
W N + + + DP + GTL++ + R ++G+ Y C A N+
Sbjct: 68 HWTRNSRFFN-IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE--------YQCFARNKF 118
Query: 121 GTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW 171
GTA+S RL V+ L + P +V G TL+C PP G P P + W
Sbjct: 119 GTALSNRIRLQVSKSPLWPKENLDP--VVVQEGAPLTLQCNPPPGLPSPVIFW 169
Score = 45.4 bits (106), Expect = 3e-04
Identities = 59/221 (26%), Positives = 88/221 (39%), Gaps = 46/221 (20%)
Query: 318 DYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNG 377
+Y+ ++ +GR GP S PE VPSAP + +P T+ + W P E+ NG
Sbjct: 914 NYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHP--EHPNG 971
Query: 378 IIRGYQVWSLGNTSLPPANWTVVGE---------QTQLEIATHMPGS-YCVQVAAVTGAG 427
I+ GY + N T VG+ QT+ + P S Y ++A T G
Sbjct: 972 IMIGYTL------KYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVG 1025
Query: 428 AGEPSRPVCLLLEQAMERATQEPSEHGP---WTLEQLRATLKRPEVIATCGVALWLLLLG 484
+G E E + P+E P +T Q + + C +AL +L+L
Sbjct: 1026 SG----------EAVTEESPAPPNEATPTAAYTNNQADIATQGWFIGLMCAIALLVLILL 1075
Query: 485 TAVCIHR--------RRRARVHLGP-------GLYRYTSED 510
I R R + V LGP G + Y+ ED
Sbjct: 1076 IVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDED 1116
Score = 37.7 bits (86), Expect = 0.055
Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 151 GEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVAT 210
G LEC G P P ++W+K G L + +L + + D G Y C+A+
Sbjct: 272 GMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLAS 330
Query: 211 NSAGH-RESRAARVSIQEPQDYTEPVELL 238
N G R + + RV P EP L+
Sbjct: 331 NKMGSIRHTISVRVK-AAPYWLDEPKNLI 358
Score = 35.8 bits (81), Expect = 0.21
Identities = 92/439 (20%), Positives = 154/439 (35%), Gaps = 76/439 (17%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPP--TIRWLLNGQPLSMVPPDPHHLLPDGTL 88
P +I P+DQ+ + ++ C+ P T+ WL + +PL + D +L
Sbjct: 532 PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI---GNRMKKEDDSL 588
Query: 89 LLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSV-----------AVLRE 137
+ R D G YTC AS L +++ A L+V A L +
Sbjct: 589 TIFGVAER-----------DQGSYTCVASTELDQDLAK-AYLTVLADQATPTNRLAALPK 636
Query: 138 DFQIQPRDM--VAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPG---RHTVSGGSL 192
+PRD+ + L P + P + + QPG H+ GS+
Sbjct: 637 GRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV 696
Query: 193 LMARAEKSDEGTYM--CVATNSAGHRE----SRAARVSIQEPQDYTEPVELLAVRIQLEN 246
A S Y +A N G S R S P+ V+ R
Sbjct: 697 NSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNME 756
Query: 247 VTL--LNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAP-WAEELLA 303
+T +N A GP R V W+ R +T W +
Sbjct: 757 ITWTPMNATSAFGPNLRYIV--KWR---------------RRETREAWNNVTVWGSRYVV 799
Query: 304 GWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGT- 362
G + YE +V+ + +GP+ ++ E P A P EV ++ N T
Sbjct: 800 GQTPVYV-------PYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTA 852
Query: 363 VFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANW--------TVVGEQTQLEIATHMP- 413
+ + W ++ G +R Y+ + +SL W + G++ + ++ P
Sbjct: 853 ISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPY 912
Query: 414 GSYCVQVAAVTGAGAGEPS 432
+Y +++ V G G G S
Sbjct: 913 SNYKLEMVVVNGRGDGPRS 931
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 96.3 bits (238), Expect = 1e-19
Identities = 70/222 (31%), Positives = 112/222 (50%), Gaps = 24/222 (10%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P L P++ + R+ C+A+G P PT++W++NG+PL PP+P+ + T++
Sbjct: 348 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF- 406
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLR-EDFQIQPRDMV--A 148
D Q S VY C SN G + A V+VL + PR+ +
Sbjct: 407 --------RDTQISSR--AVYQCNTSNEHGYLL---ANAFVSVLDVPPRMLSPRNQLIRV 453
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMARAEKSDEGTYMC 207
++ + L+C P +G P PT+ W+K+G+ L G H GSL + K D+G Y C
Sbjct: 454 ILYNRTRLDC-PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 512
Query: 208 VATNSAGHRESRAARVSIQEP-QDYTEPVELLAVR---IQLE 245
VATN G E++ R+ +++P + Y P + +A R +QLE
Sbjct: 513 VATNILGKAENQ-VRLEVKDPTRIYRMPEDQVARRGTTVQLE 553
Score = 70.1 bits (170), Expect = 1e-11
Identities = 68/233 (29%), Positives = 104/233 (44%), Gaps = 20/233 (8%)
Query: 29 DSPPQILVHPQDQLFQGP--GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDG 86
D PP++L P++QL + R+ C G P PT+RW NGQ S + +H+ +G
Sbjct: 438 DVPPRML-SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG-SNLDGGNYHVYENG 495
Query: 87 TLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDM 146
+L + D G+YTC A+N LG A ++ RL V +++ P D
Sbjct: 496 SLEIKM-----------IRKEDQGIYTCVATNILGKAENQ-VRLEVKDPTRIYRM-PEDQ 542
Query: 147 VAVVGEQFTLECGPPWGHP-EPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTY 205
VA G LEC + TVSW KD +PL + R SL + + D+G+Y
Sbjct: 543 VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKKEDDSLTIFGVAERDQGSY 601
Query: 206 MCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGP 258
CVA+ ++A + P D +EL + + +T + D P
Sbjct: 602 TCVASTELDQDLAKAYLTVLGRP-DRPRDLELTDLAERSVRLTWIPGDANNSP 653
Score = 61.2 bits (147), Expect = 5e-09
Identities = 58/204 (28%), Positives = 86/204 (42%), Gaps = 26/204 (12%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C ASG P P I W G L P D L + D G
Sbjct: 277 LECIASGVPTPDIAWYKKGGDL---PSDKAKFENFNKALRIT----------NVSEEDSG 323
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQI-QPRDMVAVVGEQFTLECGPPWGHPEPTV 169
Y C ASN++G S +SV V + + +P++++ GE L C G+P+PTV
Sbjct: 324 EYFCLASNKMG---SIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRAN-GNPKPTV 379
Query: 170 SWWKDGKPLALQP--GRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQE 227
W +G+PL P V+G +++ + S Y C +N G+ + A VS+ +
Sbjct: 380 QWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAF-VSVLD 438
Query: 228 PQDYTEPVELLAVRIQLENVTLLN 251
P +L+ R QL V L N
Sbjct: 439 -----VPPRMLSPRNQLIRVILYN 457
Score = 57.8 bits (138), Expect = 5e-08
Identities = 51/173 (29%), Positives = 75/173 (43%), Gaps = 36/173 (20%)
Query: 17 LLLLLIMGG-----MAQDSPPQI--------LVHPQDQLFQGPGPARMSCQASGQPPPTI 63
LL LL +GG M PP I +V P+D + + C+A G P P+
Sbjct: 15 LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNIL-------IECEAKGNPAPSF 67
Query: 64 RWLLNGQPLSMVPPDPHHLLP--DGTLLL-LQPPARGHAHDGQALSTDLGVYTCEASNRL 120
W N + + + DP + GTL++ + R ++G+ Y C A N+
Sbjct: 68 HWTRNSRFFN-IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE--------YQCFARNKF 118
Query: 121 GTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW 171
GTA+S RL V+ L + P +V G TL+C PP G P P + W
Sbjct: 119 GTALSNRIRLQVSKSPLWPKENLDP--VVVQEGAPLTLQCNPPPGLPSPVIFW 169
Score = 44.3 bits (103), Expect = 6e-04
Identities = 58/218 (26%), Positives = 87/218 (39%), Gaps = 45/218 (20%)
Query: 318 DYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNG 377
+Y+ ++ +GR GP S PE VPSAP + +P T+ + W P E+ NG
Sbjct: 899 NYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHP--EHPNG 956
Query: 378 IIRGYQVWSLGNTSLPPANWTVVGE---------QTQLEIATHMPGS-YCVQVAAVTGAG 427
I+ GY + N T VG+ QT+ + P S Y ++A T G
Sbjct: 957 IMIGYTL------KYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVG 1010
Query: 428 AGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRPEVIATCGVALWLLLLGTAV 487
+G E E + P+E +T Q + + C +AL +L+L
Sbjct: 1011 SG----------EAVTEESPAPPNE--AYTNNQADIATQGWFIGLMCAIALLVLILLIVC 1058
Query: 488 CIHR--------RRRARVHLGP-------GLYRYTSED 510
I R R + V LGP G + Y+ ED
Sbjct: 1059 FIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDED 1096
Score = 37.7 bits (86), Expect = 0.055
Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 3/89 (3%)
Query: 151 GEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVAT 210
G LEC G P P ++W+K G L + +L + + D G Y C+A+
Sbjct: 272 GMDLLLECIAS-GVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLAS 330
Query: 211 NSAGH-RESRAARVSIQEPQDYTEPVELL 238
N G R + + RV P EP L+
Sbjct: 331 NKMGSIRHTISVRVK-AAPYWLDEPKNLI 358
Score = 37.7 bits (86), Expect = 0.055
Identities = 87/426 (20%), Positives = 149/426 (34%), Gaps = 65/426 (15%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPP--TIRWLLNGQPLSMVPPDPHHLLPDGTL 88
P +I P+DQ+ + ++ C+ P T+ WL + +PL + D +L
Sbjct: 532 PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI---GNRMKKEDDSL 588
Query: 89 LLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVA 148
+ R D G YTC AS L + A+ + VL + + ++
Sbjct: 589 TIFGVAER-----------DQGSYTCVASTELDQDL---AKAYLTVLGRPDRPRDLELTD 634
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPG---RHTVSGGSLLMARAEKSDEGTY 205
+ L P + P + + QPG H+ GS+ A S Y
Sbjct: 635 LAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNY 694
Query: 206 M--CVATNSAGHRE----SRAARVSIQEPQDYTEPVELLAVRIQLENVTL--LNPDPAEG 257
+A N G S R S P+ V+ R +T +N A G
Sbjct: 695 QFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFG 754
Query: 258 PKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAP-WAEELLAGWQSAELGGLHWG 316
P R V W+ R +T W + G +
Sbjct: 755 PNLRYIV--KWR---------------RRETREAWNNVTVWGSRYVVGQTPVYV------ 791
Query: 317 QDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGT-VFVSWVPPPAENH 375
YE +V+ + +GP+ ++ E P A P EV ++ N T + + W ++
Sbjct: 792 -PYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTV 850
Query: 376 NGIIRGYQVWSLGNTSLPPANW--------TVVGEQTQLEIATHMP-GSYCVQVAAVTGA 426
G +R Y+ + +SL W + G++ + ++ P +Y +++ V G
Sbjct: 851 QGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGR 910
Query: 427 GAGEPS 432
G G S
Sbjct: 911 GDGPRS 916
>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
Length = 613
Score = 96.3 bits (238), Expect = 1e-19
Identities = 70/222 (31%), Positives = 112/222 (50%), Gaps = 24/222 (10%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P L P++ + R+ C+A+G P PT++W++NG+PL PP+P+ + T++
Sbjct: 331 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF- 389
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLR-EDFQIQPRDMV--A 148
D Q S VY C SN G + A V+VL + PR+ +
Sbjct: 390 --------RDTQISSR--AVYQCNTSNEHGYLL---ANAFVSVLDVPPRMLSPRNQLIRV 436
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMARAEKSDEGTYMC 207
++ + L+C P +G P PT+ W+K+G+ L G H GSL + K D+G Y C
Sbjct: 437 ILYNRTRLDC-PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 495
Query: 208 VATNSAGHRESRAARVSIQEP-QDYTEPVELLAVR---IQLE 245
VATN G E++ R+ +++P + Y P + +A R +QLE
Sbjct: 496 VATNILGKAENQ-VRLEVKDPTRIYRMPEDQVARRGTTVQLE 536
Score = 68.6 bits (166), Expect = 3e-11
Identities = 60/185 (32%), Positives = 88/185 (47%), Gaps = 19/185 (10%)
Query: 29 DSPPQILVHPQDQLFQGP--GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDG 86
D PP++L P++QL + R+ C G P PT+RW NGQ S + +H+ +G
Sbjct: 421 DVPPRML-SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG-SNLDGGNYHVYENG 478
Query: 87 TLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDM 146
+L + D G+YTC A+N LG A ++ RL V +++ P D
Sbjct: 479 SLEIKM-----------IRKEDQGIYTCVATNILGKAENQ-VRLEVKDPTRIYRM-PEDQ 525
Query: 147 VAVVGEQFTLECGPPWGHP-EPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTY 205
VA G LEC + TVSW KD +PL + R SL + + D+G+Y
Sbjct: 526 VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKKEDDSLTIFGVAERDQGSY 584
Query: 206 MCVAT 210
CVA+
Sbjct: 585 TCVAS 589
Score = 61.6 bits (148), Expect = 4e-09
Identities = 66/241 (27%), Positives = 101/241 (41%), Gaps = 32/241 (13%)
Query: 18 LLLLIMGGMAQDSPPQILVHPQ----DQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLS 73
L +L G+A+ +P ++PQ Q+ + C ASG P P I W G L
Sbjct: 225 LKVLTTRGVAERTPS--FMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL- 281
Query: 74 MVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVA 133
P D L + D G Y C ASN++G S +SV
Sbjct: 282 --PSDKAKFENFNKALRIT----------NVSEEDSGEYFCLASNKMG---SIRHTISVR 326
Query: 134 VLREDFQI-QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQP--GRHTVSGG 190
V + + +P++++ GE L C G+P+PTV W +G+PL P V+G
Sbjct: 327 VKAAPYWLDEPKNLILAPGEDGRLVCRAN-GNPKPTVQWMVNGEPLQSAPPNPNREVAGD 385
Query: 191 SLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLL 250
+++ + S Y C +N G+ + A VS+ + P +L+ R QL V L
Sbjct: 386 TIIFRDTQISSRAVYQCNTSNEHGYLLANAF-VSVLD-----VPPRMLSPRNQLIRVILY 439
Query: 251 N 251
N
Sbjct: 440 N 440
Score = 57.8 bits (138), Expect = 5e-08
Identities = 51/173 (29%), Positives = 75/173 (43%), Gaps = 36/173 (20%)
Query: 17 LLLLLIMGG-----MAQDSPPQI--------LVHPQDQLFQGPGPARMSCQASGQPPPTI 63
LL LL +GG M PP I +V P+D + + C+A G P P+
Sbjct: 15 LLCLLSLGGAIEIPMDLTQPPTITKQSAKDHIVDPRDNIL-------IECEAKGNPAPSF 67
Query: 64 RWLLNGQPLSMVPPDPHHLLP--DGTLLL-LQPPARGHAHDGQALSTDLGVYTCEASNRL 120
W N + + + DP + GTL++ + R ++G+ Y C A N+
Sbjct: 68 HWTRNSRFFN-IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE--------YQCFARNKF 118
Query: 121 GTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW 171
GTA+S RL V+ L + P +V G TL+C PP G P P + W
Sbjct: 119 GTALSNRIRLQVSKSPLWPKENLDP--VVVQEGAPLTLQCNPPPGLPSPVIFW 169
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 96.3 bits (238), Expect = 1e-19
Identities = 70/222 (31%), Positives = 112/222 (50%), Gaps = 24/222 (10%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P L P++ + R+ C+A+G P PT++W++NG+PL PP+P+ + T++
Sbjct: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF- 395
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLR-EDFQIQPRDMV--A 148
D Q S VY C SN G + A V+VL + PR+ +
Sbjct: 396 --------RDTQISSR--AVYQCNTSNEHGYLL---ANAFVSVLDVPPRMLSPRNQLIRV 442
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMARAEKSDEGTYMC 207
++ + L+C P +G P PT+ W+K+G+ L G H GSL + K D+G Y C
Sbjct: 443 ILYNRTRLDC-PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 501
Query: 208 VATNSAGHRESRAARVSIQEP-QDYTEPVELLAVR---IQLE 245
VATN G E++ R+ +++P + Y P + +A R +QLE
Sbjct: 502 VATNILGKAENQ-VRLEVKDPTRIYRMPEDQVARRGTTVQLE 542
Score = 68.6 bits (166), Expect = 3e-11
Identities = 60/185 (32%), Positives = 88/185 (47%), Gaps = 19/185 (10%)
Query: 29 DSPPQILVHPQDQLFQGP--GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDG 86
D PP++L P++QL + R+ C G P PT+RW NGQ S + +H+ +G
Sbjct: 427 DVPPRML-SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG-SNLDGGNYHVYENG 484
Query: 87 TLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDM 146
+L + D G+YTC A+N LG A ++ RL V +++ P D
Sbjct: 485 SLEIKM-----------IRKEDQGIYTCVATNILGKAENQ-VRLEVKDPTRIYRM-PEDQ 531
Query: 147 VAVVGEQFTLECGPPWGHP-EPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTY 205
VA G LEC + TVSW KD +PL + R SL + + D+G+Y
Sbjct: 532 VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKKEDDSLTIFGVAERDQGSY 590
Query: 206 MCVAT 210
CVA+
Sbjct: 591 TCVAS 595
Score = 61.6 bits (148), Expect = 4e-09
Identities = 66/241 (27%), Positives = 101/241 (41%), Gaps = 32/241 (13%)
Query: 18 LLLLIMGGMAQDSPPQILVHPQ----DQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLS 73
L +L G+A+ +P ++PQ Q+ + C ASG P P I W G L
Sbjct: 231 LKVLTTRGVAERTPS--FMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL- 287
Query: 74 MVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVA 133
P D L + D G Y C ASN++G S +SV
Sbjct: 288 --PSDKAKFENFNKALRIT----------NVSEEDSGEYFCLASNKMG---SIRHTISVR 332
Query: 134 VLREDFQI-QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQP--GRHTVSGG 190
V + + +P++++ GE L C G+P+PTV W +G+PL P V+G
Sbjct: 333 VKAAPYWLDEPKNLILAPGEDGRLVCRAN-GNPKPTVQWMVNGEPLQSAPPNPNREVAGD 391
Query: 191 SLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLL 250
+++ + S Y C +N G+ + A VS+ + P +L+ R QL V L
Sbjct: 392 TIIFRDTQISSRAVYQCNTSNEHGYLLANAF-VSVLD-----VPPRMLSPRNQLIRVILY 445
Query: 251 N 251
N
Sbjct: 446 N 446
Score = 55.1 bits (131), Expect = 3e-07
Identities = 50/179 (27%), Positives = 75/179 (41%), Gaps = 42/179 (23%)
Query: 17 LLLLLIMGGMAQ-----------DSPPQI--------LVHPQDQLFQGPGPARMSCQASG 57
LL LL +GG + PP I +V P+D + + C+A G
Sbjct: 15 LLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL-------IECEAKG 67
Query: 58 QPPPTIRWLLNGQPLSMVPPDPHHLLP--DGTLLL-LQPPARGHAHDGQALSTDLGVYTC 114
P P+ W N + + + DP + GTL++ + R ++G+ Y C
Sbjct: 68 NPAPSFHWTRNSRFFN-IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE--------YQC 118
Query: 115 EASNRLGTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW 171
A N+ GTA+S RL V+ L + P +V G TL+C PP G P P + W
Sbjct: 119 FARNKFGTALSNRIRLQVSKSPLWPKENLDP--VVVQEGAPLTLQCNPPPGLPSPVIFW 175
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 96.3 bits (238), Expect = 1e-19
Identities = 70/222 (31%), Positives = 112/222 (50%), Gaps = 24/222 (10%)
Query: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
P L P++ + R+ C+A+G P PT++W++NG+PL PP+P+ + T++
Sbjct: 337 PYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIF- 395
Query: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLR-EDFQIQPRDMV--A 148
D Q S VY C SN G + A V+VL + PR+ +
Sbjct: 396 --------RDTQISSR--AVYQCNTSNEHGYLL---ANAFVSVLDVPPRMLSPRNQLIRV 442
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMARAEKSDEGTYMC 207
++ + L+C P +G P PT+ W+K+G+ L G H GSL + K D+G Y C
Sbjct: 443 ILYNRTRLDC-PFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTC 501
Query: 208 VATNSAGHRESRAARVSIQEP-QDYTEPVELLAVR---IQLE 245
VATN G E++ R+ +++P + Y P + +A R +QLE
Sbjct: 502 VATNILGKAENQ-VRLEVKDPTRIYRMPEDQVARRGTTVQLE 542
Score = 68.6 bits (166), Expect = 3e-11
Identities = 60/185 (32%), Positives = 88/185 (47%), Gaps = 19/185 (10%)
Query: 29 DSPPQILVHPQDQLFQGP--GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDG 86
D PP++L P++QL + R+ C G P PT+RW NGQ S + +H+ +G
Sbjct: 427 DVPPRML-SPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQG-SNLDGGNYHVYENG 484
Query: 87 TLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDM 146
+L + D G+YTC A+N LG A ++ RL V +++ P D
Sbjct: 485 SLEIKM-----------IRKEDQGIYTCVATNILGKAENQ-VRLEVKDPTRIYRM-PEDQ 531
Query: 147 VAVVGEQFTLECGPPWGHP-EPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTY 205
VA G LEC + TVSW KD +PL + R SL + + D+G+Y
Sbjct: 532 VARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI-GNRMKKEDDSLTIFGVAERDQGSY 590
Query: 206 MCVAT 210
CVA+
Sbjct: 591 TCVAS 595
Score = 61.6 bits (148), Expect = 4e-09
Identities = 66/241 (27%), Positives = 101/241 (41%), Gaps = 32/241 (13%)
Query: 18 LLLLIMGGMAQDSPPQILVHPQ----DQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLS 73
L +L G+A+ +P ++PQ Q+ + C ASG P P I W G L
Sbjct: 231 LKVLTTRGVAERTPS--FMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDL- 287
Query: 74 MVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVA 133
P D L + D G Y C ASN++G S +SV
Sbjct: 288 --PSDKAKFENFNKALRIT----------NVSEEDSGEYFCLASNKMG---SIRHTISVR 332
Query: 134 VLREDFQI-QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQP--GRHTVSGG 190
V + + +P++++ GE L C G+P+PTV W +G+PL P V+G
Sbjct: 333 VKAAPYWLDEPKNLILAPGEDGRLVCRAN-GNPKPTVQWMVNGEPLQSAPPNPNREVAGD 391
Query: 191 SLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLL 250
+++ + S Y C +N G+ + A VS+ + P +L+ R QL V L
Sbjct: 392 TIIFRDTQISSRAVYQCNTSNEHGYLLANAF-VSVLD-----VPPRMLSPRNQLIRVILY 445
Query: 251 N 251
N
Sbjct: 446 N 446
Score = 55.1 bits (131), Expect = 3e-07
Identities = 50/179 (27%), Positives = 75/179 (41%), Gaps = 42/179 (23%)
Query: 17 LLLLLIMGGMAQ-----------DSPPQI--------LVHPQDQLFQGPGPARMSCQASG 57
LL LL +GG + PP I +V P+D + + C+A G
Sbjct: 15 LLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL-------IECEAKG 67
Query: 58 QPPPTIRWLLNGQPLSMVPPDPHHLLP--DGTLLL-LQPPARGHAHDGQALSTDLGVYTC 114
P P+ W N + + + DP + GTL++ + R ++G+ Y C
Sbjct: 68 NPAPSFHWTRNSRFFN-IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGE--------YQC 118
Query: 115 EASNRLGTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSW 171
A N+ GTA+S RL V+ L + P +V G TL+C PP G P P + W
Sbjct: 119 FARNKFGTALSNRIRLQVSKSPLWPKENLDP--VVVQEGAPLTLQCNPPPGLPSPVIFW 175
Score = 38.1 bits (87), Expect = 0.042
Identities = 98/437 (22%), Positives = 154/437 (35%), Gaps = 84/437 (19%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPP--TIRWLLNGQPLSMVPPDPHHLLPDGTL 88
P +I P+DQ+ + ++ C+ P T+ WL + +PL + D +L
Sbjct: 521 PTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYI---GNRMKKEDDSL 577
Query: 89 LLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSV-----------AVLRE 137
+ R D G YTC AS L +++ A L+V A L +
Sbjct: 578 TIFGVAER-----------DQGSYTCVASTELDQDLAK-AYLTVLADQATPTNRLAALPK 625
Query: 138 DFQIQPRDM--VAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPG---RHTVSGGSL 192
+PRD+ + L P + P + + QPG H+ GS+
Sbjct: 626 GRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSV 685
Query: 193 LMARAEKSDEGTYM--CVATNSAGHRE----SRAARVSIQEPQDYTEPVELLAVRIQLEN 246
A S Y +A N G S R S P+ V+ R
Sbjct: 686 NSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNME 745
Query: 247 VTL--LNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQGAP-WAEELLA 303
+T +N A GP R V W+ R +T W +
Sbjct: 746 ITWTPMNATSAFGPNLRYIV--KWR---------------RRETREAWNNVTVWGSRYVV 788
Query: 304 GWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTV 363
G + YE +V+ + +GP+ ++ E +PSAP + +P T+
Sbjct: 789 GQTPVYV-------PYEIRVQAENDFGKGPEPESVIGYSGEDLPSAPRRFRVRQPNLETI 841
Query: 364 FVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGE---------QTQLEIATHMPG 414
+ W P E+ NGI+ GY + N T VG+ QT+ + P
Sbjct: 842 NLEWDHP--EHPNGIMIGYTL------KYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPV 893
Query: 415 S-YCVQVAAVTGAGAGE 430
S Y ++A T G+GE
Sbjct: 894 SRYRFTLSARTQVGSGE 910
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 95.1 bits (235), Expect = 3e-19
Identities = 102/405 (25%), Positives = 166/405 (40%), Gaps = 50/405 (12%)
Query: 40 DQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHA 99
D P R C+A+G+P PT RWL NG PLS P + +G L++
Sbjct: 398 DTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMI--------- 445
Query: 100 HDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQP--RDMVAVVGEQFTLE 157
+D G+Y C A N+ G A+ A L + F + + ++ ++ +E
Sbjct: 446 --HNVNQSDAGMYQCLAENKYG-AIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIE 502
Query: 158 CGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRE 217
C P G P+PT+SW K + + + GSL + A KSDEG Y+C N G E
Sbjct: 503 CKPQ-GSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAE 561
Query: 218 SRAARVSIQEPQDYTEPVELLAVRIQL---ENVTLLNPDPAEGPKPRPAVWLSWKVSGPA 274
A +S++EP +EL R +L E++ L + V W + G
Sbjct: 562 I-IASLSVKEP----TRIELTPKRTELTVGESIVLNCKAIHDASLD---VTFYWTLKGQP 613
Query: 275 APAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPD 334
+ F + A +L +H G+ Y +V+ ++ D
Sbjct: 614 IDFEEEGGHFESIRAQASSADLMIRNILL---------MHAGR-YGCRVQTTADSV--SD 661
Query: 335 SNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGI----IRGYQVWSLGNT 390
LL+R P P P + + T +SW P A+NH+ I ++ +SLG
Sbjct: 662 EAELLVRGP---PGPPGIVIVEEITESTATLSW-SPAADNHSPISSYNLQARSPFSLGWQ 717
Query: 391 SLPPANWTVVGE-QTQLEIATHMPGSYCVQVAAVTGAGAGEPSRP 434
++ + G+ ++ + + + Y +V A G G+PS P
Sbjct: 718 TVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 762
Score = 76.6 bits (187), Expect = 1e-13
Identities = 56/191 (29%), Positives = 91/191 (47%), Gaps = 19/191 (9%)
Query: 29 DSPPQILVHPQDQLFQGPGPAR---MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85
D P + P D +F + ++C+ G P P+ RWL NG + + D + L D
Sbjct: 96 DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDL-ESDYRYSLID 154
Query: 86 GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRD 145
GT ++ P + + D G Y C A+N +G+ +SR A L A L +F + R
Sbjct: 155 GTFIISNP----------SEAKDSGHYQCLATNTVGSILSREATLQFAYL-GNFSGRTRS 203
Query: 146 MVAV-VGEQFTLECGPPWGHPEPTVSW-WKDGKPLALQPGRHTVS--GGSLLMARAEKSD 201
V+V G+ L C PP PE SW + + + R +S G+L +++ + SD
Sbjct: 204 AVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSD 263
Query: 202 EGTYMCVATNS 212
G+Y+C+ N+
Sbjct: 264 VGSYICLVKNT 274
Score = 60.5 bits (145), Expect = 8e-09
Identities = 68/265 (25%), Positives = 98/265 (36%), Gaps = 39/265 (14%)
Query: 14 SLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPA-RMSCQASGQPPPTIRWL-LNGQP 71
S P L L G+ + P+I VH + G +M C A G P PTI W+ +NG
Sbjct: 282 SPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYI 341
Query: 72 LSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST-------DLGVYTCEASNRLGTAV 124
P++ QA+ D G+Y C A N G
Sbjct: 342 ----------------------PSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNS 379
Query: 125 SRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR 184
RG +L V + + D G EC G P PT W K+G PL+ Q R
Sbjct: 380 FRG-QLQVYTYPHWVE-KLNDTQLDSGSPLRWEC-KATGKPRPTYRWLKNGVPLSPQ-SR 435
Query: 185 HTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQL 244
+ G L++ +SD G Y C+A N G + A + + + +
Sbjct: 436 VEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTK 495
Query: 245 ENVTLLNPDPAEGPKPRPAVWLSWK 269
+ ++ P PKP +SWK
Sbjct: 496 DQEVVIECKPQGSPKPT----ISWK 516
Score = 39.7 bits (91), Expect = 0.014
Identities = 24/99 (24%), Positives = 48/99 (48%), Gaps = 2/99 (2%)
Query: 163 GHPEPTVSWWKDGKPLALQPG-RHTVSGGSLLMAR-AEKSDEGTYMCVATNSAGHRESRA 220
G+P P+ W ++G + L+ R+++ G+ +++ +E D G Y C+ATN+ G SR
Sbjct: 127 GNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSRE 186
Query: 221 ARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPK 259
A + +++ + + V L+ P P+
Sbjct: 187 ATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPE 225
Score = 39.7 bits (91), Expect = 0.014
Identities = 57/235 (24%), Positives = 84/235 (35%), Gaps = 31/235 (13%)
Query: 44 QGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQ 103
+G G M P W+ N P S V D + T G+ + +
Sbjct: 209 EGQGVVLMCSPPPHSPEIIYSWVFNEFP-SFVAEDSRRFISQET---------GNLYISK 258
Query: 104 ALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQ---------PRDMVAVVGEQF 154
++D+G Y C N + A + + + + P + A G
Sbjct: 259 VQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTV 318
Query: 155 TLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAG 214
+EC G+P PT++W K + R S L + + D G Y C A NS G
Sbjct: 319 KMECFA-LGNPVPTITWMKVNGYIP-SKARLRKSQAVLEIPNVQLDDAGIYECRAENSRG 376
Query: 215 HRESRAARVSIQEPQDYTEP--VELLAVRIQLENVTLLNPDPAEGPKPRPAV-WL 266
R + Q YT P VE L QL++ + L + KPRP WL
Sbjct: 377 KNSFRG------QLQVYTYPHWVEKLN-DTQLDSGSPLRWECKATGKPRPTYRWL 424
Score = 37.7 bits (86), Expect = 0.055
Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 12/131 (9%)
Query: 310 LGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVP 369
L GL Y F VR +G GP S+ + + PS P + + V + W P
Sbjct: 937 LTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEP 996
Query: 370 P-PAENHNGIIRGYQVW--SLGNTSLPPANWTVVGEQTQLEIATHMP--GSYCVQVAAVT 424
P N + ++ GY+V+ G+++ + V E +L+ +P G Y ++V A +
Sbjct: 997 VIPLANESEVV-GYKVFYRQEGHSN------SQVIETQKLQAVVPLPDAGVYIIEVRAYS 1049
Query: 425 GAGAGEPSRPV 435
G G S +
Sbjct: 1050 EGGDGTASSQI 1060
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 95.1 bits (235), Expect = 3e-19
Identities = 102/405 (25%), Positives = 166/405 (40%), Gaps = 50/405 (12%)
Query: 40 DQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHA 99
D P R C+A+G+P PT RWL NG PLS P + +G L++
Sbjct: 324 DTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLS---PQSRVEMVNGVLMI--------- 371
Query: 100 HDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQP--RDMVAVVGEQFTLE 157
+D G+Y C A N+ G A+ A L + F + + ++ ++ +E
Sbjct: 372 --HNVNQSDAGMYQCLAENKYG-AIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIE 428
Query: 158 CGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRE 217
C P G P+PT+SW K + + + GSL + A KSDEG Y+C N G E
Sbjct: 429 CKPQ-GSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAE 487
Query: 218 SRAARVSIQEPQDYTEPVELLAVRIQL---ENVTLLNPDPAEGPKPRPAVWLSWKVSGPA 274
A +S++EP +EL R +L E++ L + V W + G
Sbjct: 488 I-IASLSVKEP----TRIELTPKRTELTVGESIVLNCKAIHDASLD---VTFYWTLKGQP 539
Query: 275 APAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPD 334
+ F + A +L +H G+ Y +V+ ++ D
Sbjct: 540 IDFEEEGGHFESIRAQASSADLMIRNILL---------MHAGR-YGCRVQTTADSV--SD 587
Query: 335 SNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGI----IRGYQVWSLGNT 390
LL+R P P P + + T +SW P A+NH+ I ++ +SLG
Sbjct: 588 EAELLVRGP---PGPPGIVIVEEITESTATLSW-SPAADNHSPISSYNLQARSPFSLGWQ 643
Query: 391 SLPPANWTVVGE-QTQLEIATHMPGSYCVQVAAVTGAGAGEPSRP 434
++ + G+ ++ + + + Y +V A G G+PS P
Sbjct: 644 TVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 688
Score = 76.6 bits (187), Expect = 1e-13
Identities = 56/191 (29%), Positives = 91/191 (47%), Gaps = 19/191 (9%)
Query: 29 DSPPQILVHPQDQLFQGPGPAR---MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85
D P + P D +F + ++C+ G P P+ RWL NG + + D + L D
Sbjct: 22 DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDL-ESDYRYSLID 80
Query: 86 GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRD 145
GT ++ P + + D G Y C A+N +G+ +SR A L A L +F + R
Sbjct: 81 GTFIISNP----------SEAKDSGHYQCLATNTVGSILSREATLQFAYL-GNFSGRTRS 129
Query: 146 MVAV-VGEQFTLECGPPWGHPEPTVSW-WKDGKPLALQPGRHTVS--GGSLLMARAEKSD 201
V+V G+ L C PP PE SW + + + R +S G+L +++ + SD
Sbjct: 130 AVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSD 189
Query: 202 EGTYMCVATNS 212
G+Y+C+ N+
Sbjct: 190 VGSYICLVKNT 200
Score = 60.5 bits (145), Expect = 8e-09
Identities = 68/265 (25%), Positives = 98/265 (36%), Gaps = 39/265 (14%)
Query: 14 SLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPA-RMSCQASGQPPPTIRWL-LNGQP 71
S P L L G+ + P+I VH + G +M C A G P PTI W+ +NG
Sbjct: 208 SPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYI 267
Query: 72 LSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST-------DLGVYTCEASNRLGTAV 124
P++ QA+ D G+Y C A N G
Sbjct: 268 ----------------------PSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNS 305
Query: 125 SRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR 184
RG +L V + + D G EC G P PT W K+G PL+ Q R
Sbjct: 306 FRG-QLQVYTYPHWVE-KLNDTQLDSGSPLRWEC-KATGKPRPTYRWLKNGVPLSPQ-SR 361
Query: 185 HTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQL 244
+ G L++ +SD G Y C+A N G + A + + + +
Sbjct: 362 VEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTK 421
Query: 245 ENVTLLNPDPAEGPKPRPAVWLSWK 269
+ ++ P PKP +SWK
Sbjct: 422 DQEVVIECKPQGSPKPT----ISWK 442
Score = 39.7 bits (91), Expect = 0.014
Identities = 24/99 (24%), Positives = 48/99 (48%), Gaps = 2/99 (2%)
Query: 163 GHPEPTVSWWKDGKPLALQPG-RHTVSGGSLLMAR-AEKSDEGTYMCVATNSAGHRESRA 220
G+P P+ W ++G + L+ R+++ G+ +++ +E D G Y C+ATN+ G SR
Sbjct: 53 GNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSRE 112
Query: 221 ARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPK 259
A + +++ + + V L+ P P+
Sbjct: 113 ATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPE 151
Score = 39.7 bits (91), Expect = 0.014
Identities = 57/235 (24%), Positives = 84/235 (35%), Gaps = 31/235 (13%)
Query: 44 QGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQ 103
+G G M P W+ N P S V D + T G+ + +
Sbjct: 135 EGQGVVLMCSPPPHSPEIIYSWVFNEFP-SFVAEDSRRFISQET---------GNLYISK 184
Query: 104 ALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQ---------PRDMVAVVGEQF 154
++D+G Y C N + A + + + + P + A G
Sbjct: 185 VQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTV 244
Query: 155 TLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAG 214
+EC G+P PT++W K + R S L + + D G Y C A NS G
Sbjct: 245 KMECFA-LGNPVPTITWMKVNGYIP-SKARLRKSQAVLEIPNVQLDDAGIYECRAENSRG 302
Query: 215 HRESRAARVSIQEPQDYTEP--VELLAVRIQLENVTLLNPDPAEGPKPRPAV-WL 266
R + Q YT P VE L QL++ + L + KPRP WL
Sbjct: 303 KNSFRG------QLQVYTYPHWVEKLN-DTQLDSGSPLRWECKATGKPRPTYRWL 350
Score = 37.7 bits (86), Expect = 0.055
Identities = 34/131 (25%), Positives = 57/131 (43%), Gaps = 12/131 (9%)
Query: 310 LGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVP 369
L GL Y F VR +G GP S+ + + PS P + + V + W P
Sbjct: 863 LTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEP 922
Query: 370 P-PAENHNGIIRGYQVW--SLGNTSLPPANWTVVGEQTQLEIATHMP--GSYCVQVAAVT 424
P N + ++ GY+V+ G+++ + V E +L+ +P G Y ++V A +
Sbjct: 923 VIPLANESEVV-GYKVFYRQEGHSN------SQVIETQKLQAVVPLPDAGVYIIEVRAYS 975
Query: 425 GAGAGEPSRPV 435
G G S +
Sbjct: 976 EGGDGTASSQI 986
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 94.4 bits (233), Expect = 5e-19
Identities = 65/201 (32%), Positives = 93/201 (46%), Gaps = 27/201 (13%)
Query: 25 GMAQDSPPQILVHPQDQLFQGP----GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPH 80
G+ + PP+I + P GP P R++C A+G P PT+ WL +G P+S
Sbjct: 779 GLRVNVPPRITLPPS---LPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGL 835
Query: 81 HLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLG---TAVSRGARLSVAVLRE 137
+ P G +L L A ++D G Y+C A + +G V + ++L E
Sbjct: 836 QVFPGGRVLTL----------ASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGE 885
Query: 138 DFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMA-R 196
+ + V E LEC P P +SWWKDG+PL +PG H + +LL R
Sbjct: 886 ELNVS-----VVANESVALEC-QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDR 939
Query: 197 AEKSDEGTYMCVATNSAGHRE 217
A+ D G Y C A N AG E
Sbjct: 940 ADVWDAGHYTCEALNQAGRSE 960
Score = 88.6 bits (218), Expect = 3e-17
Identities = 60/185 (32%), Positives = 83/185 (44%), Gaps = 20/185 (10%)
Query: 47 GPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALS 106
G ++ C G P P I W+ +G PL H L +G+L + +
Sbjct: 3043 GSIQLDCVVRGDPVPDIHWIKDGLPLR--GSHLRHQLQNGSLTIHRTER----------- 3089
Query: 107 TDLGVYTCEASNRLGTAVSRGARLSVAVLRED--FQIQPRDMVAVVGEQFTLECGPPWGH 164
D G Y C A N +G A ++ + VL+ FQ++P+DM G+ L C G
Sbjct: 3090 DDAGRYQCLAENEMGVA----KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT-GE 3144
Query: 165 PEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVS 224
P PT+ W + G+PL T+ GSL + E D GTY CVA N G +RA V
Sbjct: 3145 PTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 3204
Query: 225 IQEPQ 229
EPQ
Sbjct: 3205 RGEPQ 3209
Score = 86.3 bits (212), Expect = 1e-16
Identities = 60/174 (34%), Positives = 84/174 (48%), Gaps = 22/174 (12%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
P + C+A G PPP IRW +P+S P + +LL G +L + Q
Sbjct: 1178 PLTLLCEAMGIPPPAIRWFRGEEPVS--PGEDTYLLAGGWMLKMT----------QTQEQ 1225
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVV----GEQFTLECGPPWG 163
D G+Y+C ASN G A SV VL I+ D+ V+ G+ L C G
Sbjct: 1226 DSGLYSCLASNEAGEA---RRNFSVEVLVPP-SIENEDLEEVIKVLDGQTAHLMCNVT-G 1280
Query: 164 HPEPTVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGHR 216
HP+P ++W+KDG+PLA H G LL + +A S G Y C+A N+ G +
Sbjct: 1281 HPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 1334
Score = 85.9 bits (211), Expect = 2e-16
Identities = 67/186 (36%), Positives = 91/186 (48%), Gaps = 16/186 (8%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
P +SC+ G P P I W +GQPL H+ G LL L GQA
Sbjct: 988 PTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYL----------GQAQLA 1037
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAVLRE-DFQIQPRDMVAVVGEQF-TLECGPPWGHP 165
G YTCE SN +G + S+ +L V V + +P V+VV + TLEC G P
Sbjct: 1038 QEGTYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNAT-GKP 1095
Query: 166 EPTVSWWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVS 224
PTV+W +DG+P+ + G + G SL + RA+ + G Y CVA N AG R R +S
Sbjct: 1096 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELS 1154
Query: 225 IQEPQD 230
+ P +
Sbjct: 1155 VLVPPE 1160
Score = 85.1 bits (209), Expect = 3e-16
Identities = 80/255 (31%), Positives = 110/255 (43%), Gaps = 45/255 (17%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPH-HLLPDGTLLLLQPPARGHAHDGQALSTDL 109
+ C A G P PTI WL NG P S P P +L DG +L + A D
Sbjct: 1674 LQCPALGNPVPTISWLQNGLPFS---PSPRLQVLEDGQVLQV----------STAEVADA 1720
Query: 110 GVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTV 169
Y C A N+ G+A + L V V + + A++ +L C HP P V
Sbjct: 1721 ASYMCVAENQAGSA-EKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPC-DVHAHPNPEV 1778
Query: 170 SWWKD------GKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARV 223
+W+KD G+ + L PG HT L + RA SD G Y C A N+AG R+ + ++
Sbjct: 1779 TWYKDSQALSLGEEVFLLPGTHT-----LQLGRARLSDSGMYTCEALNAAG-RDQKLVQL 1832
Query: 224 SIQEPQDYTE----PVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSG-PAAPAQ 278
S+ P + + P + + VR+ + V D P P V +W G P AQ
Sbjct: 1833 SVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL----PEPTV--TWYKDGQPLVLAQ 1886
Query: 279 SYTALFRTQTAPGGQ 293
RTQ GGQ
Sbjct: 1887 ------RTQALRGGQ 1895
Score = 83.2 bits (204), Expect = 1e-15
Identities = 89/302 (29%), Positives = 127/302 (42%), Gaps = 55/302 (18%)
Query: 50 RMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDL 109
++ C+A G P P I W +G LLP T ++ R G+A S+D
Sbjct: 330 QLLCEARGVPTPNITWFKDGA-----------LLPTSTKVVYTRGGR-QLQLGRAQSSDA 377
Query: 110 GVYTCEASNRLGTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHPEP 167
GVYTC+ASN +G A + RL V V E +P + AV G LEC GHP P
Sbjct: 378 GVYTCKASNAVG-AAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALEC-VARGHPSP 435
Query: 168 TVSWWKDGKPLALQPGRHTVSGGSLLMARAE-KSDEGTYMCVATNSAGHRESRAARVSIQ 226
T+SW +G P+A + GS+L + ++ G Y CVA++ AG + + V +Q
Sbjct: 436 TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYS-VEVQ 494
Query: 227 EPQDYTEPVELLAVRIQLENVTLLNPDPAEGP-----KPRPAV-WL-----SWKVSGPAA 275
P L V L VT + P E P P P + WL + +++G
Sbjct: 495 VPPQ-------LLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQV 547
Query: 276 PAQ-----------SYTALFRTQTAPGGQGAPWAE-------ELLAGWQSAELGGLHWGQ 317
+Q ++ LF Q A G AE E G +G HWG
Sbjct: 548 ASQGTTLHIDHVELDHSGLFACQ-ATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGX 606
Query: 318 DY 319
++
Sbjct: 607 EH 608
Score = 80.9 bits (198), Expect = 6e-15
Identities = 81/239 (33%), Positives = 112/239 (46%), Gaps = 32/239 (13%)
Query: 50 RMSCQASGQPPPTIRWLLNGQPLSM-VPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTD 108
R+ C+A GQPPP + WL +G PL + P L G+L+L +G ++D
Sbjct: 2045 RLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVL-----KG------LRASD 2093
Query: 109 LGVYTCEASNRLGTAVSRGARL-SVAVLREDFQIQPRD----MVAVVGEQFTLECGPPWG 163
G YTC A N G ARL +V VL Q D +V+ GE T+ C P G
Sbjct: 2094 AGAYTCVAHNPAG----EDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVC-PVRG 2148
Query: 164 HPEPTVSWWKDGKPLALQPGRHTV---SGGSLLMARAEKSDEGTYMCVATNSAGHRESRA 220
P VSW KDG PL L + T+ SG +L +++ + +D G + CVA + AG + R
Sbjct: 2149 SPPIHVSWLKDGLPLPL--SQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVAD-RN 2205
Query: 221 ARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQS 279
+ +Q P EPVE + + + P A G P P V SW G +QS
Sbjct: 2206 FTLQVQVP-PVLEPVEFQNDVVVVRGSLVELPCEARG-VPLPLV--SWMKDGEPLLSQS 2260
Score = 80.5 bits (197), Expect = 7e-15
Identities = 64/188 (34%), Positives = 89/188 (47%), Gaps = 19/188 (10%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C P P + W + Q LS+ + LLP L L G+A +D G
Sbjct: 1766 LPCDVHAHPNPEVTWYKDSQALSL--GEEVFLLPGTHTLQL----------GRARLSDSG 1813
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQIQ--PRDMVAV-VGEQFTLECGPPWGHPEP 167
+YTCEA N G + +LSV V Q P+D V V VG++ L C PEP
Sbjct: 1814 MYTCEALNAAGRD-QKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETD-ALPEP 1871
Query: 168 TVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGHRESRAARVSIQ 226
TV+W+KDG+PL L + GG L + A+ SD+G Y C +N AG R +++Q
Sbjct: 1872 TVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTVQ 1930
Query: 227 EPQDYTEP 234
P + P
Sbjct: 1931 VPPTFENP 1938
Score = 79.3 bits (194), Expect = 2e-14
Identities = 72/254 (28%), Positives = 116/254 (45%), Gaps = 38/254 (14%)
Query: 5 GDSLLGGRGSLPLLLLLIMGGMAQDSPPQILVHPQDQLFQGP------------GPARMS 52
G + L G+ ++G +QD ++ V PQ GP G A +
Sbjct: 1032 GQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ---IAGPREPPTQVSVVQDGVATLE 1088
Query: 53 CQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHA-HDGQALSTDLGV 111
C A+G+PPPT+ W +GQP+ G L LQ +G + H +A + G
Sbjct: 1089 CNATGKPPPTVTWERDGQPV-------------GAELGLQLQNQGQSLHVERAQAAHTGR 1135
Query: 112 YTCEASNRLGTAVSRGARLSVAVLREDF-QIQP-RDMVAVVGEQFTLECGPPWGHPEPTV 169
Y+C A N G A R LSV V E + P ++ A + TL C G P P +
Sbjct: 1136 YSCVAENLAGRA-ERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLC-EAMGIPPPAI 1193
Query: 170 SWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGH-RESRAARVSIQ- 226
W++ +P++ + ++GG +L M + ++ D G Y C+A+N AG R + + V +
Sbjct: 1194 RWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPP 1253
Query: 227 --EPQDYTEPVELL 238
E +D E +++L
Sbjct: 1254 SIENEDLEEVIKVL 1267
Score = 79.0 bits (193), Expect = 2e-14
Identities = 65/235 (27%), Positives = 100/235 (42%), Gaps = 33/235 (14%)
Query: 17 LLLLLIMGGMAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVP 76
LL I+GG + ++ V + P + C+A P P I W+ +G P
Sbjct: 1343 LLAPTILGGAEDSADEEVTVTVNN-------PISLICEALAFPSPNITWMKDGAPFEA-- 1393
Query: 77 PDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSR---GARLSVA 133
+ L P G A D G YTC +N LG AV + +
Sbjct: 1394 ---------SRNIQLLPGTHG-LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPS 1443
Query: 134 VLRED--FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGS 191
+ ++D ++ +++ V TLEC W P PT+ W+KDG+P+ + G
Sbjct: 1444 ISKDDPLGEVGVKEVKTKVNSTLTLEC-ESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGR 1502
Query: 192 LLMAR-AEKSDEGTYMCVATNSAGHRESRAARVSIQEPQ------DYTEPVELLA 239
LL + + SD G Y+CVATN AG + + V IQ P D++ E+L+
Sbjct: 1503 LLQIQPTQVSDSGRYLCVATNVAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILS 1556
Score = 79.0 bits (193), Expect = 2e-14
Identities = 60/200 (30%), Positives = 84/200 (42%), Gaps = 20/200 (10%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP I D P ++C ++G P PT+ W G L + + P G L +
Sbjct: 2665 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG-ARGSGYRVSPSGALEI 2723
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMV--A 148
GQAL G YTC A N G A ++ ++P V A
Sbjct: 2724 -----------GQALPIHAGRYTCSARNSAGVAHKH----VFLTVQASPVVKPLPSVVRA 2768
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCV 208
V E+ L C G P PT++W K+G +A + GG L +A A D G Y+C+
Sbjct: 2769 VAEEEVLLPCEAS-GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCI 2827
Query: 209 ATNSAGHRESRAARVSIQEP 228
A NSAG + R+ +Q P
Sbjct: 2828 AKNSAGSAMGK-TRLVVQVP 2846
Score = 75.9 bits (185), Expect = 2e-13
Identities = 59/170 (34%), Positives = 78/170 (45%), Gaps = 17/170 (10%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C+ASG P PTI W G L++ +LP G L + AH A D G
Sbjct: 2776 LPCEASGIPRPTITWQKEG--LNVATGVSTQVLPGGQLRI--------AH---ASPEDAG 2822
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVS 170
Y C A N G+A+ + RL V V P D+ G L C G PEP ++
Sbjct: 2823 NYLCIAKNSAGSAMGK-TRLVVQVPPVIENGLP-DLSTTEGSHAFLPCKAR-GSPEPNIT 2879
Query: 171 WWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEGTYMCVATNSAGHRESR 219
W KDG+P++ G+ T+ G LL+ E D GTY C A N+ G R
Sbjct: 2880 WDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRR 2929
Score = 74.7 bits (182), Expect = 4e-13
Identities = 60/177 (33%), Positives = 81/177 (45%), Gaps = 16/177 (9%)
Query: 38 PQDQLFQGPGP-ARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPAR 96
PQD + G A +SC+ P PT+ W +GQPL V L G L +Q
Sbjct: 1847 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPL--VLAQRTQALRGGQRLEIQ---- 1900
Query: 97 GHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTL 156
+A +D G+Y+C+ SN G AV R L+V V + + V G L
Sbjct: 1901 ------EAQVSDKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVL 1953
Query: 157 ECGPPWGHPEPTVSWWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEGTYMCVATNS 212
C G P PTV+W KD P+ VS GG L ++R + + GTY CVA N+
Sbjct: 1954 TCDVS-GVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENT 2009
Score = 74.3 bits (181), Expect = 5e-13
Identities = 80/270 (29%), Positives = 109/270 (40%), Gaps = 38/270 (14%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSM-VPPDPHHLLPDGTLL 89
PP I P + PA + C+ASG P P + W +GQ L + + LLP LL
Sbjct: 2572 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALL 2631
Query: 90 LLQPPARGHAHDGQALSTDLGVYTCEASNRLGTA-----VSRGARLSVAVLREDFQIQPR 144
L P + D + C SN +G A V+ ++A + DF +
Sbjct: 2632 LTAPGPQ-----------DSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTV--- 2677
Query: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVS-GGSLLMARAEKSDEG 203
M+A V L C G P PTVSW K G L + + VS G+L + +A G
Sbjct: 2678 TMMAPV----VLTCHST-GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAG 2732
Query: 204 TYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Y C A NSAG P +P+ + + E V L P A G PRP
Sbjct: 2733 RYTCSARNSAGVAHKHVFLTVQASP--VVKPLPSVVRAVAEEEVLL--PCEASG-IPRPT 2787
Query: 264 VWLSWKVSGPAAPAQSYTALFRTQTAPGGQ 293
+ +W+ G + TQ PGGQ
Sbjct: 2788 I--TWQKEG-----LNVATGVSTQVLPGGQ 2810
Score = 74.3 bits (181), Expect = 5e-13
Identities = 64/211 (30%), Positives = 93/211 (44%), Gaps = 22/211 (10%)
Query: 49 ARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTD 108
A + C+A G P P I W +GQP+S + P G LL+ +GQ D
Sbjct: 2864 AFLPCKARGSPEPNITWDKDGQPVSGA-EGKFTIQPSGELLVKN-------LEGQ----D 2911
Query: 109 LGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPT 168
G YTC A N +G A R L++ VL F P D +G++ L C G P P
Sbjct: 2912 AGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDRLWLRCAAR-GSPTPR 2968
Query: 169 VSWWKDGKPLALQPGRHTVSGGSLLM-ARAEKSDEGTYMCVATNSAGHRES----RAARV 223
+ W + +P+ G GGS L A + D GTY+C A N G ++
Sbjct: 2969 IGWTVNDRPVT--EGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEA 3026
Query: 224 SIQEPQDYTEPVELLAVRIQLENVTLLNPDP 254
+ + + ++ VE + IQL+ V +P P
Sbjct: 3027 PVLQGEAFSYLVEPVGGSIQLDCVVRGDPVP 3057
Score = 73.6 bits (179), Expect = 9e-13
Identities = 53/173 (30%), Positives = 82/173 (47%), Gaps = 16/173 (9%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
PA + C + PPP + W QPLS D +L G +L + P R +
Sbjct: 1576 PAYLYCDTNAIPPPDLTWYREDQPLS--AGDEVSVLQGGRVLQI-PLVR---------AE 1623
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVA--VLREDFQIQPRDMVAVVGEQFTLECGPPWGHP 165
+ G Y+C+ASN +G L + V+ D + ++ +L+C P G+P
Sbjct: 1624 NAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-PALGNP 1682
Query: 166 EPTVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAGHRE 217
PT+SW ++G P + P + G +L ++ AE +D +YMCVA N AG E
Sbjct: 1683 VPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE 1735
Score = 73.6 bits (179), Expect = 9e-13
Identities = 66/195 (33%), Positives = 85/195 (43%), Gaps = 30/195 (15%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHD---GQALST 107
M C G PP + WL +G PL L TLL G H +
Sbjct: 2142 MVCPVRGSPPIHVSWLKDGLPLP---------LSQRTLL------HGSGHTLRISKVQLA 2186
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAV--LREDFQIQPRDMVAVVGEQFTLECGPPWGHP 165
D G++TC A++ G A R L V V + E + Q D+V V G L C G P
Sbjct: 2187 DAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQ-NDVVVVRGSLVELPCEAR-GVP 2243
Query: 166 EPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSI 225
P VSW KDG+PL Q G SL + D GTY CVA + AG R ++++
Sbjct: 2244 LPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEAR-RHFQLTV 2299
Query: 226 QEP---QDYTEPVEL 237
EP +D +P EL
Sbjct: 2300 MEPPHIEDSGQPTEL 2314
Score = 72.8 bits (177), Expect = 2e-12
Identities = 76/256 (29%), Positives = 104/256 (40%), Gaps = 44/256 (17%)
Query: 31 PPQILVHP---QDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGT 87
PPQ+LV Q G P + CQASG P PTI+WL NG+P + + GT
Sbjct: 496 PPQLLVAEGLGQVTTIVGQ-PLELPCQASGSPVPTIQWLQNGRPAEELA--GVQVASQGT 552
Query: 88 LLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMV 147
L + H+ G++ C+A+N GTA GA + V+V E P +
Sbjct: 553 TLHIDHVELDHS----------GLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLE 596
Query: 148 AVVGE---------QFTLECGPP----WG-HPE-PTVSWWKDGKPLALQPGRHTVSGG-- 190
+G+ F C PP WG HP+ P V W L +P V+
Sbjct: 597 VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 656
Query: 191 -SLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTL 249
L + + + DEG Y C ATN AG + A + P PV + LEN ++
Sbjct: 657 PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVN----KAVLENASV 712
Query: 250 LNPDPAEGPKPRPAVW 265
A G P W
Sbjct: 713 TLECLASGVPPPDVSW 728
Score = 72.4 bits (176), Expect = 2e-12
Identities = 77/265 (29%), Positives = 108/265 (40%), Gaps = 52/265 (19%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST-DL 109
+ C A G P P I W +N +P++ + DG G A+S D
Sbjct: 2957 LRCAARGSPTPRIGWTVNDRPVTEGVSEQ-----DG----------GSTLQRAAVSREDS 3001
Query: 110 GVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRD---MVAVVGEQFTLECGPPWGHPE 166
G Y C A NR+G R +S ++E +Q +V VG L+C G P
Sbjct: 3002 GTYVCWAENRVG----RTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR-GDPV 3056
Query: 167 PTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRES------RA 220
P + W KDG PL RH + GSL + R E+ D G Y C+A N G + ++
Sbjct: 3057 PDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQS 3116
Query: 221 ARVSIQEPQDYT-EPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQS 279
A V EPQD T + +A+R Q +P P + W +G Q
Sbjct: 3117 APVFQVEPQDMTVRSGDDVALRCQATG------------EPTPTI--EWLQAG-----QP 3157
Query: 280 YTALFRTQTAPGGQGAPWAEELLAG 304
A R +T P G+ W E + G
Sbjct: 3158 LRASRRLRTLP--DGSLWLENVETG 3180
Score = 71.6 bits (174), Expect = 3e-12
Identities = 74/252 (29%), Positives = 100/252 (39%), Gaps = 31/252 (12%)
Query: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
PP I P ++ + C ASG PPP + W QP+S + DG +L
Sbjct: 694 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVT--VSVDGRVLR 751
Query: 91 LQPPARGHAHDGQALSTDLGVYTCEASNRLG-TAVSRGARLSVAVLREDFQIQPR-DMVA 148
++ QA +D G Y C ASN G T + G R++V + P
Sbjct: 752 IE----------QAQLSDAGSYRCVASNVAGSTELRYGLRVNVP---PRITLPPSLPGPV 798
Query: 149 VVGEQFTLECGPPWGHPEPTVSWWKDGKPL--ALQPGRHTVSGGSLL-MARAEKSDEGTY 205
+V L C G P PT+ W KDG P+ A PG GG +L +A A SD G Y
Sbjct: 799 LVNTPVRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 857
Query: 206 MCVATNSAGHRESRAARVSIQEPQDYTEPVELLAV---RIQLENVTLLNPDP-------A 255
CVA ++ G P E + + V + LE + P P
Sbjct: 858 SCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDG 917
Query: 256 EGPKPRPAVWLS 267
+PRP V LS
Sbjct: 918 RPLEPRPGVHLS 929
Score = 71.2 bits (173), Expect = 4e-12
Identities = 57/176 (32%), Positives = 82/176 (46%), Gaps = 30/176 (17%)
Query: 48 PARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALST 107
P + C A G P PT+ W G P++ + L DG++L L+ P G+A S
Sbjct: 422 PVALECVARGHPSPTLSWHHEGLPVA--ESNESRLETDGSVLRLESP-------GEASS- 471
Query: 108 DLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVA--------VVGEQFTLECG 159
G+Y+C AS+ G AV + SV V Q+ P+ +VA +VG+ L C
Sbjct: 472 --GLYSCVASSPAGEAV---LQYSVEV-----QVPPQLLVAEGLGQVTTIVGQPLELPCQ 521
Query: 160 PPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLL-MARAEKSDEGTYMCVATNSAG 214
G P PT+ W ++G+P G S G+ L + E G + C ATN AG
Sbjct: 522 AS-GSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAG 576
Score = 68.6 bits (166), Expect = 3e-11
Identities = 89/296 (30%), Positives = 121/296 (40%), Gaps = 38/296 (12%)
Query: 30 SPPQILVHPQDQLFQ---GPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDG 86
+PP I V P+ F PG + C +P P I W +G L D H
Sbjct: 2387 APPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQ---EDAH------ 2436
Query: 87 TLLLLQPPARGHAHDGQALST-DLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRD 145
Q P RG QALST D G Y+C A N G+ S R+ + + + P
Sbjct: 2437 ----TQFPERGRFLQLQALSTADSGDYSCTARNAAGST-SVAFRVEIHTV-PTIRSGPPA 2490
Query: 146 MVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTV-SGGSLLMARAEKSDEGT 204
+ V + L C G P P VSW KD PL + R + GSL + D G
Sbjct: 2491 VNVSVNQTALLPCQAD-GVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGH 2549
Query: 205 YMCVATNSAG-HRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPA 263
Y+C+A+NSAG R+ R RV ++ P P L + LL + + PKP
Sbjct: 2550 YLCLASNSAGSDRQGRDLRV-LEPPAIAPSPSNL---TLTAHTPALLPCEASGSPKPLVV 2605
Query: 264 VW-----LSWKVSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLH 314
W L +++ A AL TAPG Q + E ++ S E+G H
Sbjct: 2606 WWKDGQKLDFRLQQGAYRLLPSNALL--LTAPGPQDSAQFECVV----SNEVGEAH 2655
Score = 63.2 bits (152), Expect = 1e-09
Identities = 60/206 (29%), Positives = 89/206 (43%), Gaps = 24/206 (11%)
Query: 30 SPPQILVH--PQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPH-HLLPDG 86
+PP +L Q+ L + C SG P P + W + QP ++P PH + DG
Sbjct: 214 APPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQP--VLPGGPHLQVQEDG 271
Query: 87 TLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDM 146
+L + +H G D G Y C A + G +R +L V +
Sbjct: 272 QVLRIT-----GSHVG-----DEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGE 320
Query: 147 VAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR----HTVSGGSLLMARAEKSDE 202
VAV+ + G P P ++W+KDG AL P +T G L + RA+ SD
Sbjct: 321 VAVMEDHLVQLLCEARGVPTPNITWFKDG---ALLPTSTKVVYTRGGRQLQLGRAQSSDA 377
Query: 203 GTYMCVATNSAGHRESRAARVSIQEP 228
G Y C A+N+ G E +A R+ + P
Sbjct: 378 GVYTCKASNAVGAAE-KATRLDVYVP 402
Score = 57.0 bits (136), Expect = 9e-08
Identities = 48/184 (26%), Positives = 72/184 (39%), Gaps = 24/184 (13%)
Query: 51 MSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLG 110
+ C+A G P P + W+ +G+PL L G L L+ G D G
Sbjct: 2235 LPCEARGVPLPLVSWMKDGEPLLS------QSLEQGPSLQLEAVGAG----------DSG 2278
Query: 111 VYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVS 170
Y+C A + G A + + QP ++ G L C G P+P ++
Sbjct: 2279 TYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQ-GTPQPNIT 2337
Query: 171 WWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQD 230
W KDG+ L + S D G Y C+A + AG E ++ RV +Q P +
Sbjct: 2338 WHKDGQALT------RLENNSRATRVLRVRDAGLYTCLAESPAGAIE-KSFRVRVQAPPN 2390
Query: 231 YTEP 234
P
Sbjct: 2391 IVGP 2394
Score = 56.6 bits (135), Expect = 1e-07
Identities = 36/97 (37%), Positives = 44/97 (45%), Gaps = 13/97 (13%)
Query: 30 SPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLL 89
S P V PQD + + CQA+G+P PTI WL GQPL LPDG+L
Sbjct: 3116 SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLR--ASRRLRTLPDGSLW 3173
Query: 90 LLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSR 126
L + D G Y C A N LG+A +R
Sbjct: 3174 L-----------ENVETGDAGTYDCVAHNLLGSATAR 3199
Score = 50.4 bits (119), Expect = 8e-06
Identities = 80/309 (25%), Positives = 107/309 (34%), Gaps = 37/309 (11%)
Query: 163 GHPEPTVSWWK--DGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSAGHRESRA 220
G P+P V+W K +PL QPG + GSL +A +D G Y C ATN G SR
Sbjct: 28 GTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG-STSRR 86
Query: 221 ARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSY 280
A++ + P E V L D P P VWL AQ
Sbjct: 87 AKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE-IVWLK--------DAQ-- 135
Query: 281 TALFRTQTAPGGQGAPWAEELLAGWQSAELGG---LHWGQDYEF-KVRPS-SGRARGPDS 335
G G W GW ++GG L GQ F +++P SGR
Sbjct: 136 ----LVGVPLGWAGYGWD----LGW--GQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAG 185
Query: 336 NVLLLRLPEKVPSA-----PPQEVTLKPGNGTVFVSWVPPPAENHNGIIRGYQVWSLGNT 390
+ P A P P +V + G Q W+ G
Sbjct: 186 GSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSG-V 244
Query: 391 SLPPANWTVVGEQTQLEIATHMPGSYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQ-E 449
P WT Q L H+ QV +TG+ G+ R C+ A ++A +
Sbjct: 245 PTPQVEWT-KDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQ 303
Query: 450 PSEHGPWTL 458
H P T+
Sbjct: 304 LRVHAPPTI 312
Score = 45.8 bits (107), Expect = 2e-04
Identities = 42/141 (29%), Positives = 61/141 (43%), Gaps = 32/141 (22%)
Query: 53 CQASGQPPPTIRWL-------LNGQPLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQAL 105
C G P P + W L+GQP V L +G+L L
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAV-------LEEGSLFL-----------ASVS 65
Query: 106 STDLGVYTCEASNRLGTAVSRGARLSVAV---LREDFQIQPRDMVAVVGEQFTLECGPPW 162
D G Y C+A+N +G + SR A+L V V +RED + ++ + G+ TLEC
Sbjct: 66 PADSGDYECQATNEVG-STSRRAKLVVYVPPSIREDG--RKANVSGMAGQSLTLECDAN- 121
Query: 163 GHPEPTVSWWKDGKPLALQPG 183
G P P + W KD + + + G
Sbjct: 122 GFPVPEIVWLKDAQLVGVPLG 142
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,275,352
Number of Sequences: 37866
Number of extensions: 3082183
Number of successful extensions: 21046
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 331
Number of HSP's successfully gapped in prelim test: 998
Number of HSP's that attempted gapping in prelim test: 12200
Number of HSP's gapped (non-prelim): 6670
length of query: 1007
length of database: 18,247,518
effective HSP length: 112
effective length of query: 895
effective length of database: 14,006,526
effective search space: 12535840770
effective search space used: 12535840770
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.