Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 170650670

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|170650670 Leber congenital amaurosis 5 [Homo sapiens]
         (697 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|170650672 Leber congenital amaurosis 5 [Homo sapiens]             1378   0.0  
gi|170650670 Leber congenital amaurosis 5 [Homo sapiens]             1378   0.0  
gi|22749049 Leber congenital amaurosis 5-like [Homo sapiens]          204   2e-52
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    80   5e-15
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    77   4e-14
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    74   3e-13
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    72   2e-12
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    71   3e-12
gi|118498356 kinectin 1 isoform a [Homo sapiens]                       71   4e-12
gi|118498368 kinectin 1 isoform c [Homo sapiens]                       71   4e-12
gi|33620775 kinectin 1 isoform a [Homo sapiens]                        71   4e-12
gi|148746195 trichohyalin [Homo sapiens]                               71   4e-12
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    71   4e-12
gi|118498362 kinectin 1 isoform b [Homo sapiens]                       69   1e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     69   1e-11
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    67   6e-11
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         67   7e-11
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         67   7e-11
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    66   1e-10
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]    66   1e-10
gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]        65   2e-10
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                65   3e-10
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    64   4e-10
gi|4503509 eukaryotic translation initiation factor 3, subunit 1...    63   1e-09
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                    63   1e-09
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    62   2e-09
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    62   2e-09
gi|41872583 Rho-associated, coiled-coil containing protein kinas...    62   2e-09
gi|58530840 desmoplakin isoform I [Homo sapiens]                       61   3e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    61   3e-09

>gi|170650672 Leber congenital amaurosis 5 [Homo sapiens]
          Length = 697

 Score = 1378 bits (3566), Expect = 0.0
 Identities = 697/697 (100%), Positives = 697/697 (100%)

Query: 1   MGERAGSPGTDQERKAGKHHYSYLSDFETPQSSGRSSLVSSSPASVRRKNPKRQTSDGQV 60
           MGERAGSPGTDQERKAGKHHYSYLSDFETPQSSGRSSLVSSSPASVRRKNPKRQTSDGQV
Sbjct: 1   MGERAGSPGTDQERKAGKHHYSYLSDFETPQSSGRSSLVSSSPASVRRKNPKRQTSDGQV 60

Query: 61  HHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVS 120
           HHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVS
Sbjct: 61  HHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVS 120

Query: 121 ELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQE 180
           ELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQE
Sbjct: 121 ELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQE 180

Query: 181 KERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIK 240
           KERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIK
Sbjct: 181 KERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIK 240

Query: 241 ELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSN 300
           ELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSN
Sbjct: 241 ELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSN 300

Query: 301 RLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEE 360
           RLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEE
Sbjct: 301 RLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEE 360

Query: 361 PGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKK 420
           PGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKK
Sbjct: 361 PGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKK 420

Query: 421 QKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQD 480
           QKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQD
Sbjct: 421 QKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQD 480

Query: 481 SRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSG 540
           SRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSG
Sbjct: 481 SRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSG 540

Query: 541 NVRSPASPNEFAFGSYVPSFAKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITRKEK 600
           NVRSPASPNEFAFGSYVPSFAKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITRKEK
Sbjct: 541 NVRSPASPNEFAFGSYVPSFAKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITRKEK 600

Query: 601 KANLMEQLFGASGSSTISSKSSDPNSVASSKGDIDPLNFLPGNKGSRDQEHDEDEGFFLS 660
           KANLMEQLFGASGSSTISSKSSDPNSVASSKGDIDPLNFLPGNKGSRDQEHDEDEGFFLS
Sbjct: 601 KANLMEQLFGASGSSTISSKSSDPNSVASSKGDIDPLNFLPGNKGSRDQEHDEDEGFFLS 660

Query: 661 EGRSFNPNRHRLKHADDKPAVKAADSVEDEIEEVALR 697
           EGRSFNPNRHRLKHADDKPAVKAADSVEDEIEEVALR
Sbjct: 661 EGRSFNPNRHRLKHADDKPAVKAADSVEDEIEEVALR 697


>gi|170650670 Leber congenital amaurosis 5 [Homo sapiens]
          Length = 697

 Score = 1378 bits (3566), Expect = 0.0
 Identities = 697/697 (100%), Positives = 697/697 (100%)

Query: 1   MGERAGSPGTDQERKAGKHHYSYLSDFETPQSSGRSSLVSSSPASVRRKNPKRQTSDGQV 60
           MGERAGSPGTDQERKAGKHHYSYLSDFETPQSSGRSSLVSSSPASVRRKNPKRQTSDGQV
Sbjct: 1   MGERAGSPGTDQERKAGKHHYSYLSDFETPQSSGRSSLVSSSPASVRRKNPKRQTSDGQV 60

Query: 61  HHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVS 120
           HHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVS
Sbjct: 61  HHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVS 120

Query: 121 ELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQE 180
           ELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQE
Sbjct: 121 ELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQE 180

Query: 181 KERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIK 240
           KERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIK
Sbjct: 181 KERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIK 240

Query: 241 ELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSN 300
           ELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSN
Sbjct: 241 ELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSN 300

Query: 301 RLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEE 360
           RLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEE
Sbjct: 301 RLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEE 360

Query: 361 PGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKK 420
           PGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKK
Sbjct: 361 PGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKK 420

Query: 421 QKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQD 480
           QKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQD
Sbjct: 421 QKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQD 480

Query: 481 SRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSG 540
           SRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSG
Sbjct: 481 SRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSG 540

Query: 541 NVRSPASPNEFAFGSYVPSFAKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITRKEK 600
           NVRSPASPNEFAFGSYVPSFAKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITRKEK
Sbjct: 541 NVRSPASPNEFAFGSYVPSFAKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITRKEK 600

Query: 601 KANLMEQLFGASGSSTISSKSSDPNSVASSKGDIDPLNFLPGNKGSRDQEHDEDEGFFLS 660
           KANLMEQLFGASGSSTISSKSSDPNSVASSKGDIDPLNFLPGNKGSRDQEHDEDEGFFLS
Sbjct: 601 KANLMEQLFGASGSSTISSKSSDPNSVASSKGDIDPLNFLPGNKGSRDQEHDEDEGFFLS 660

Query: 661 EGRSFNPNRHRLKHADDKPAVKAADSVEDEIEEVALR 697
           EGRSFNPNRHRLKHADDKPAVKAADSVEDEIEEVALR
Sbjct: 661 EGRSFNPNRHRLKHADDKPAVKAADSVEDEIEEVALR 697


>gi|22749049 Leber congenital amaurosis 5-like [Homo sapiens]
          Length = 670

 Score =  204 bits (519), Expect = 2e-52
 Identities = 165/546 (30%), Positives = 278/546 (50%), Gaps = 62/546 (11%)

Query: 98  DLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEI 157
           D +  RILSARL KI  L+NE++++  KL  +L EN+ LK+LQ R  KA+ K+E+++N +
Sbjct: 137 DAMAHRILSARLHKIKGLKNELADMHHKLEAILTENQFLKQLQLRHLKAIGKYENSQNNL 196

Query: 158 SQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPE 217
            Q++ +H NE+  L++ LRKSQEKER   +++++T+S+L +TK  LQ L+++SE ++L E
Sbjct: 197 PQIMAKHQNEVKNLRQLLRKSQEKERTLSRKLRETDSQLLKTKDILQALQKLSEDKNLAE 256

Query: 218 RDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKE 277
           R++L  KL     K+D  +++I+ L K L L+  +F RQL  E ++   A    K LQ E
Sbjct: 257 REELTHKLSIITTKMDANDKKIQSLEKQLRLNCRAFSRQLAIETRKTLAAQTATKTLQVE 316

Query: 278 VQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTME 337
           V+ L  KLKEK+REL+IKNIYS+R+ K+  + E    +    + Q+D   L    ++   
Sbjct: 317 VKHLQQKLKEKDRELEIKNIYSHRILKNLHDTEDYPKVSSTKSVQADRKILPFTSMRHQG 376

Query: 338 DFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQD-RHGEAGILNPIMEREE-----K 391
             K +  PLT +      N         +D + +  +  H     +N + ++E+     +
Sbjct: 377 TQKSDVPPLTTKGKKATGN---------IDHKEKSTEINHEIPHCVNKLPKQEDSKRKYE 427

Query: 392 FVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNM 451
            ++ EE H+   EV+ L +   R++  K+ +EK ++  +EE+ E      ++ ++P +  
Sbjct: 428 DLSGEEKHL---EVQILLENTGRQKDKKEDQEKKNIFVKEEQ-ELPPKIIEV-IHPERES 482

Query: 452 DKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRF 511
           ++      E+ KR M   + N +D  L       Y   PL            R  + Y F
Sbjct: 483 NQEDVLVREKFKRSM---QRNGVDDTLGKG-TAPYTKGPL------------RQRRHYSF 526

Query: 512 SESSERLFNGHHLQDISFSTPKGEGQNSGNVRSPASPNEFAFGSYVPSFAKTSERSNPFS 571
           +E++E L +G            G   N+GN+R            Y  S  K         
Sbjct: 527 TEATENLHHG--------LPASGGPANAGNMR------------YSHSTGKHLSNREEME 566

Query: 572 QKSSFLDFQRNSMEKLSKDGVDLITRKEKKANLMEQLFGASGSSTISSKSSDPNSVASSK 631
            + S   ++  S  K S+  V   T ++KK++LME+LFG+          +D +S   +K
Sbjct: 567 LEHSDSGYEP-SFGKSSRIKVKDTTFRDKKSSLMEELFGSG-----YVLKTDQSSPGVAK 620

Query: 632 GDIDPL 637
           G  +PL
Sbjct: 621 GSEEPL 626


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 93/457 (20%), Positives = 213/457 (46%), Gaps = 40/457 (8%)

Query: 83  FRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKL--AELLK---ENKSLK 137
           +R+   N E  +K+ +L  K  L+    + +E+Q  V EL+ KL  A+ L    +  +L+
Sbjct: 176 YRNTITNEELKKKNAELQEKLRLAES--EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ 233

Query: 138 RLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELF 197
              +RQE+ L + E    +  + ++R    +   + ++R+ +EK R  EKR+++ E EL 
Sbjct: 234 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKEL- 292

Query: 198 RTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQL 257
                 ++ KE+ E + L E+++   ++   E K+ + E +++E  + +         Q 
Sbjct: 293 -----REQEKELREQKKLREQEE---QMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE 344

Query: 258 LAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRK 317
              R++  +  D+ + + ++ +RL  K +E+ RE +       ++ +    +E+E  +R+
Sbjct: 345 KQMREQEQKMRDQEERMWEQDERLREK-EERMREQEKMWEQEEKMQEEERIREREKKMRE 403

Query: 318 NAACQSDFADLCTKGVQTM-----EDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQK 372
                 +  +   K  + M     ++++ +  P   E +   + K +E      + + + 
Sbjct: 404 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW-EQEKMQEQEEKIWEQEEKI 462

Query: 373 QDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDE----WERE----ELDKKQKEK 424
           +D+    G     M R+EK + ++E  + +QE EK+ D+    W++E    E D++ +EK
Sbjct: 463 RDQEEMWG-QEKKMWRQEK-MREQEDQMWEQE-EKMRDQEQKMWDQEERMWEQDERLREK 519

Query: 425 ASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNL 484
              + RE+K  W+           Q  +K   ++EE+++ E    ++ E ++++++   +
Sbjct: 520 EERM-REQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE---ERMREREKKMREEEEM 575

Query: 485 KYPVLPLLPDFESKLHSPERS--PKTYRFSESSERLF 519
                  + + E K+   E     +  +  E  E+++
Sbjct: 576 MREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMW 612



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 74/401 (18%), Positives = 190/401 (47%), Gaps = 40/401 (9%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           ++ E + E+ E + +L E  K  +  +++Q ++EK   + E+   E  + ++R    +  
Sbjct: 284 RLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQ-EEKMREQEEKMWRQEERLWE 342

Query: 171 LKERLRKSQEKERATEKRV-------KDTESELFRTKFSLQKLKEISEARHLPERDDLAK 223
            ++++R+ ++K R  E+R+       ++ E  +   +   ++ +++ E   + ER+   K
Sbjct: 343 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRERE---K 399

Query: 224 KLVSAELKLDDTERRIKELSKNL-ELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLY 282
           K+   E  + + E ++++  +N+ E     +Q+Q L E+K   E   E + +Q++ ++++
Sbjct: 400 KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK---EKLWEQEKMQEQEEKIW 456

Query: 283 HKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPE 342
            + +EK R+ +       ++ +    +E+E  + +      D         + M + + E
Sbjct: 457 EQ-EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWE-QDE 514

Query: 343 EYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVK 402
                 E +   +  W++   +  + ++Q+Q++           ++EEK   +E +   +
Sbjct: 515 RLREKEERMREQKKMWQQEEKMREEKKTQEQEKK--------TWDQEEKMREEERMRERE 566

Query: 403 QEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERL 462
           +++ + E+E  RE+ +K Q+++  + E+EEK  WE              +K+Q +EE+  
Sbjct: 567 KKMRE-EEEMMREQEEKMQEQEEKMREQEEK-MWE------------QEEKMQEQEEKMW 612

Query: 463 KREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPE 503
           ++E  + +  E D+ +Q+   + +     + + E K+   E
Sbjct: 613 EQEEKMWEQEEEDK-MQEQEEMMWEQEEKMQEQEEKMWEQE 652



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 72/391 (18%), Positives = 172/391 (43%), Gaps = 26/391 (6%)

Query: 114 ELQNEVSELQVKLAELLKENKSLKRLQYRQEKAL-NKFEDAENEISQLIFRHNNEITALK 172
           E   E   ++ +  ++ +E ++++  + + +K   N +E  E E  Q       E    +
Sbjct: 386 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 445

Query: 173 ERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKL 232
           E++++ +EK    E++++D E    + K   ++ K   +   + E+++   K+   E K+
Sbjct: 446 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE---KMRDQEQKM 502

Query: 233 DDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKEREL 292
            D E R+ E  + L       + + + E+K+ ++        Q+E  R   K +E+E++ 
Sbjct: 503 WDQEERMWEQDERLRE-----KEERMREQKKMWQ--------QEEKMREEKKTQEQEKKT 549

Query: 293 DIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIM 352
             +     ++ +    +E+E  +R+      +  +   +  + M + + + +    +   
Sbjct: 550 WDQE---EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQE 606

Query: 353 CYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEW 412
             E  WE+   +    +  K     E      + E+EEK    EE    ++E  + ++E 
Sbjct: 607 QEEKMWEQEEKMWEQEEEDKMQEQEEM-----MWEQEEKMQEQEEKMWEQEEKMREQEEK 661

Query: 413 EREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNM-DKLQGEEEERLKREMLLAKL 471
            RE+ +K Q ++  + E+EEK + +  + +     ++   +K+ G+EE+   +E  +   
Sbjct: 662 MREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 721

Query: 472 NEIDRELQDSRNLKYPVLPLLPDFESKLHSP 502
            E+  + +  R+ K  +   LP+ E +   P
Sbjct: 722 EEMREKEERIRDQKEKMQERLPEHEERCSEP 752



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 82/431 (19%), Positives = 190/431 (44%), Gaps = 53/431 (12%)

Query: 84  RSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQ 143
           R +   +E   ++ +L  ++ L  +  ++ E + ++ E + K+ E  ++    +   + Q
Sbjct: 284 RLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 343

Query: 144 EKALNKFEDAENEISQLIFRHNNEITALKERLR----------KSQEKERATE--KRVKD 191
           EK + + E    +  + ++  +  +   +ER+R          K QE+ER  E  K++++
Sbjct: 344 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMRE 403

Query: 192 TESELFRTKFSLQKLKEIS--------EARHLPERDDLA---KKLVSAELKLDDTERRIK 240
            E  +   +  +QK +E          + + LPE+ +     +K+   E K+ + E +I+
Sbjct: 404 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 463

Query: 241 ELSKNLELSTNSFQRQLLAERK-RAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYS 299
           +  +        ++++ + E++ + +E  ++ +  ++++     ++ E++  L  K    
Sbjct: 464 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE--- 520

Query: 300 NRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWE 359
            R+ +     ++E  +R+    Q           Q  + +  EE     E +   E K  
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQE----------QEKKTWDQEEKMREEERMREREKKMR 570

Query: 360 EPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEV--EKLEDEWEREEL 417
           E   +  + + + Q++  +      + E+EEK    EE    ++E   E+ E  WE+EE 
Sbjct: 571 EEEEMMREQEEKMQEQEEK------MREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624

Query: 418 DKKQKEKASLLEREEKPE------WETGRYQLGMYP--IQNMDKLQGEEEERLKREMLLA 469
           DK Q+++  + E+EEK +      WE             +  +K+QG+EE+  ++E  + 
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQ 684

Query: 470 KLNEIDRELQD 480
              E  RE ++
Sbjct: 685 GQEEKMREQEE 695


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 98/485 (20%), Positives = 212/485 (43%), Gaps = 64/485 (13%)

Query: 83  FRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKL--AELLK---ENKSLK 137
           +R+   N E  +K+ +L  K  L+    + +E+Q  V EL+ KL  A+ L    +  +L+
Sbjct: 214 YRNTITNEELKKKNAELQEKLPLAES--EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ 271

Query: 138 RLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELF 197
              +RQE+ L + E    +  + ++R    +   + ++R+ +EK    EKR+++ E EL 
Sbjct: 272 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELR 331

Query: 198 RTKFSLQKLKEISEARHLPERD-----DLAKKLVSAELKLDDTERRIKELSKNL---ELS 249
             +  L++ KE+ E     +       +  +K+   E K+   E R+ E  K +   E  
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391

Query: 250 TNSFQRQLLAERKRAYEAHD---ENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSS 306
               + ++  + +R  E  +   E + + ++V+++  + K +E+E   ++    ++ +  
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRD-QEEKMQEEE 450

Query: 307 PNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEY--PLTPETIMCYENKWEEPGHL 364
             +E+E  +R+      +  +   K  + M + + +E+     PE     E  WE+    
Sbjct: 451 RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ---KEKLWEQE--- 504

Query: 365 TLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEV---EKLEDE----WEREEL 417
              +Q Q++           I E+EEK    EE+   ++++   EK+ ++    WE+EE 
Sbjct: 505 --KMQEQEE----------KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552

Query: 418 DKKQKEK--------ASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLA 469
            + Q++K            + +EK  W+          ++  +K   EEEE ++ +    
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE--E 610

Query: 470 KLNEIDRELQDSRNLKYPVLPLLPDFESKL--------HSPERSPKTYRFSESSERLFNG 521
           K+ E + ++Q+     +     + + E K+           E+  +  R  E  E+L+  
Sbjct: 611 KMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 670

Query: 522 HHLQD 526
             +Q+
Sbjct: 671 EKMQE 675



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 81/393 (20%), Positives = 177/393 (45%), Gaps = 42/393 (10%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           ++ E + ++ E + K+ E  ++ +  +   +RQE+ L + E    E  Q +      +  
Sbjct: 342 ELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 401

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLA---KKLVS 227
             ERLR+ +E+ R  EK  +  E      K   Q+ K   +   + E + +    KK+  
Sbjct: 402 QDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE 461

Query: 228 AELKLDDTERRIKELSKNL-ELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLK 286
            E  + + E ++++  +N+ E     +Q+Q L E+K   E   E + +Q++ ++++ + +
Sbjct: 462 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQK---EKLWEQEKMQEQEEKIWEQ-E 517

Query: 287 EKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPL 346
           EK R+ +       ++ +    +E+E  + +      D         + ME    E+   
Sbjct: 518 EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKK 577

Query: 347 TPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVE 406
           T          W++   +  + + +++++          M  EE+ + ++E  + +QE +
Sbjct: 578 T----------WDQEEKMREEERMREREKK---------MREEEEMMREQEEKMQEQEEK 618

Query: 407 KLEDE---WEREELDKKQKEKA-----SLLEREEKPEWETGRY-----QLGMY-PIQNMD 452
             E E   WE+EE  ++Q+EK       + E+EEK  WE  R      +L  +  +Q  +
Sbjct: 619 MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM-WEQQRLPEQKEKLWEHEKMQEQE 677

Query: 453 KLQGEEEERLKREMLLAKLNEIDRELQDSRNLK 485
           K+Q +EE+  ++E +  K  E +++  D   ++
Sbjct: 678 KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMR 710



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 68/361 (18%), Positives = 169/361 (46%), Gaps = 31/361 (8%)

Query: 114 ELQNEVSELQVKLAELLKENKSLKRLQYRQEKAL-NKFEDAENEISQLIFRHNNEITALK 172
           E   E   ++ +  ++ +E ++++  + + +K   N +E  E E  Q       E    +
Sbjct: 444 EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503

Query: 173 ERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKL 232
           E++++ +EK    E++++D E    + K   ++ K   +   + E+++   K+   E K+
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE---KMRDQEQKM 560

Query: 233 DDTERRIKELSKNLELSTNSFQRQLLAE---RKRAYEAHDENKVLQKEVQRLYH---KLK 286
            D E R+++ ++  E  T   + ++  E   R+R  +  +E ++++++ +++     K++
Sbjct: 561 WDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQ 620

Query: 287 EKEREL-DIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTK-----GVQTMEDFK 340
           E+E ++ + +     +  K    +EK     +    Q    +   K      +Q  E  +
Sbjct: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680

Query: 341 PEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHV 400
            +E  +  +  M  E K +E    T D +  +++          + ERE+K   +EE+  
Sbjct: 681 EQEEKIWEQEKM--EKKTQEQEKKTWDQEKMREEES--------MREREKKMREEEEM-- 728

Query: 401 VKQEVEKLEDEWER--EELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEE 458
           ++++ EK++++ E+  E+ ++  +++  + E+EEK  WE  R       +   +K+Q +E
Sbjct: 729 MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM-WEQQRLPEQKEKLWEHEKMQEQE 787

Query: 459 E 459
           +
Sbjct: 788 K 788



 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 73/371 (19%), Positives = 168/371 (45%), Gaps = 56/371 (15%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           K+ E + ++ E + K+ +  +E    ++  +RQEK + + ED   E  + +     ++  
Sbjct: 505 KMQEQEEKIWEQEEKIRDQ-EEMWGQEKKMWRQEK-MREQEDQMWEQEEKMRDQEQKMWD 562

Query: 171 LKERL-RKSQEKERAT---------EKRVKDTESELFRTKFSLQKLKEISEARHLPERDD 220
            +ER+ +K+QE+E+ T         E+R+++ E ++ R +  + + +E        +  +
Sbjct: 563 QEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM-REEEEMMREQEEKMQEQEEKMQE 621

Query: 221 LAKKLVSAELKLDDTERRIKELSKNL-ELSTNSFQRQLLAERKRAYEAHD---ENKVLQK 276
             +K+   E K+ + E ++ E  + + E     +++Q L E+K     H+   E + +Q+
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681

Query: 277 EVQRLYH--KLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQ 334
           + ++++   K+++K +E + K     ++ +    +E+E  +R+      +  +   +  +
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741

Query: 335 TMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVT 394
            M++ + E +    +     E  WE+                        + E++EK   
Sbjct: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQ----------------------QRLPEQKEKLWE 779

Query: 395 DEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKL 454
            E++    QE EK+   WE+EE  + Q+EK    E + + + E  R Q         +K+
Sbjct: 780 HEKM----QEQEKI---WEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ--------EEKM 824

Query: 455 QGEEEERLKRE 465
            G+EE+   +E
Sbjct: 825 WGQEEKMWGQE 835


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 104/443 (23%), Positives = 188/443 (42%), Gaps = 53/443 (11%)

Query: 82   GFRSQSLNRE--PLRKDTDLVTKRILSARLL--KINELQNEVSELQVKLAELLKENKSLK 137
            G R++ L  E   L K+ +L+ K+I + ++   KI  L+ E SEL+ +  +L K   S K
Sbjct: 624  GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683

Query: 138  RLQYRQEKALNKFEDAENEISQLIFRHNNE---ITALKERLRKSQEKERATEKRVKDTES 194
             L ++ E +L K E+++ +   L  R N E     ++K    + + KE  +EK       
Sbjct: 684  NLTFQLE-SLEK-ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741

Query: 195  ELFRTKFSLQKLKEIS------EARHLPER-DDLAKKLVSAELKLDDTERRIKELSKNLE 247
            EL +  F   +  E+S      E + L +  ++  KK+   E +L D E   + L KNLE
Sbjct: 742  ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801

Query: 248  -LSTNSFQRQLLAERKRAYEAHD-----ENKVLQKEVQRLYHKLKEKERELDIKNIYSNR 301
             L  +S + + L +  ++ E        + K L+KE +RL  + + K+  L+  N+    
Sbjct: 802  ELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861

Query: 302  LPKSSPNKEKELALRKNAACQ--------SDFADLCTKGVQTM----EDFKPEEYPLTPE 349
            L K +    KE+ + K +  +         +     T  ++T+    ED   E+   T +
Sbjct: 862  LEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK-TQQ 920

Query: 350  TIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLE 409
                 E    E   + L+ +    D          ++E + +    + L + ++++  LE
Sbjct: 921  MNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE 980

Query: 410  DEWE---------REELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEE 460
               E         R+EL   +K   +L +R+++      R      PI   D     E +
Sbjct: 981  ARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE-----RMVQSSPPISGEDNKWERESQ 1035

Query: 461  RLKREMLLAKLNEIDRELQDSRN 483
               RE+L  K    DR ++  RN
Sbjct: 1036 ETTRELLKVK----DRLIEVERN 1054



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 97/412 (23%), Positives = 181/412 (43%), Gaps = 69/412 (16%)

Query: 85  SQSLNREPLRKDTDLVTKRILSARLLKINELQNE-----VSEL--------QVKLAELLK 131
           S+ L +E  + +  + T R  S R +KI E +NE     VS L        + ++ ++ K
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587

Query: 132 ENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKD 191
           ENK L          L+K E  + +I +       E+   KE+  +++E E   E    +
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKK-------ELEHYKEKGERAEELE--NELHHLE 638

Query: 192 TESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTN 251
            E+EL + K +  K+                +K+ + E +  + ER  ++L K L+ S  
Sbjct: 639 KENELLQKKITNLKI--------------TCEKIEALEQENSELERENRKLKKTLD-SFK 683

Query: 252 SFQRQLLAERKRAYEAHDENKVLQKEVQRL-YHKLKEKERELDIKNIYSNRLPKSSPNKE 310
           +   QL +  K   +  +EN  L++ V+ L    +K  + +L+ K + S +        +
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK-----EQLK 738

Query: 311 KELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQS 370
           K L L K +  +++  ++  +G+    D + +    T E      NK  +       L+S
Sbjct: 739 KGLELLKASFKKTERLEVSYQGL----DIENQRLQKTLEN----SNKKIQ------QLES 784

Query: 371 QKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLER 430
           + QD   E   L   +  EE  ++ + L  +++E + LE E  + E DKKQ EK +   R
Sbjct: 785 ELQDLEMENQTLQKNL--EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842

Query: 431 EEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAK-----LNEIDRE 477
           ++  E +    +     I N++K    E + L +E+ + K     L E+++E
Sbjct: 843 QQ-AEIKDTTLEENNVKIGNLEK----ENKTLSKEIGIYKESCVRLKELEKE 889



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 105/462 (22%), Positives = 203/462 (43%), Gaps = 87/462 (18%)

Query: 91  EPLRKDTDLV--TKRILS-------ARLLKINELQNEVSELQVKL--------------A 127
           E L++D  ++  TK +L        AR  K++EL+ E  +L+ KL               
Sbjct: 347 EELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE 406

Query: 128 ELLKENKSLKRLQYR-QEKALNKFEDAE--------NEISQLIFRHN-NEITALK----- 172
           EL++EN +L+  Q +  +++L+   + E        +E  Q    H  NE+T+ +     
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466

Query: 173 ---ERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE---------ISEARHLPERDD 220
              + L K+ E+ R T   V+   S++ + +   Q+L +         + E + L    +
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526

Query: 221 LAKKLVSAELKLDDT--------ERRIKEL---SKNLELSTNSF-QRQLLAERKRAYEAH 268
           L+K L+  + +L+ T        ER+IK L   +++L  + +S  QR  ++   R  +  
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586

Query: 269 DENKVLQKEVQRLYHKLKEKERE-LDIKNIYSNRLPKSSPNKEKELAL----RKNAACQS 323
            ENK+L + ++    KL + E E   IK    +   K    +E E  L    ++N   Q 
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQK 646

Query: 324 DFADL---CTKGVQTMEDFKPE---EYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHG 377
              +L   C K ++ +E    E   E     +T+  ++N       LT  L+S +++ + 
Sbjct: 647 KITNLKITCEK-IEALEQENSELERENRKLKKTLDSFKN-------LTFQLESLEKE-NS 697

Query: 378 EAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWE 437
           +    N  + R  + +    + + + ++E  E E E+E+L K  +   +  ++ E+ E  
Sbjct: 698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757

Query: 438 TGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQ 479
              YQ G+  I+N    +  E    K + L ++L +++ E Q
Sbjct: 758 ---YQ-GL-DIENQRLQKTLENSNKKIQQLESELQDLEMENQ 794



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 62/239 (25%), Positives = 97/239 (40%), Gaps = 33/239 (13%)

Query: 85   SQSLNREPLRKDTDLVTKRILSARLLKINE-LQNEVS---ELQVKLAELLKENKSL-KRL 139
            ++ L ++   KDT L    +    L K N+ L  E+    E  V+L EL KENK L KR 
Sbjct: 838  NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRA 897

Query: 140  QYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRK---SQEKERATEKRVKDTESEL 196
                +  +   ED  +E  +   + NN++  L   L K   ++E+    E+   D+  +L
Sbjct: 898  TIDIKTLVTLREDLVSEKLKTQ-QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956

Query: 197  FRTKF--SLQKLKEISEAR----------------HLPERDDLAKKLVSAELKLDDTERR 238
              +K   +L+K  EI E +                 L +     KK   A  +  D ER 
Sbjct: 957  LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016

Query: 239  IKEL------SKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERE 291
            ++            E  +    R+LL  + R  E    N  LQ E Q L  +LK+ E +
Sbjct: 1017 VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 50/231 (21%), Positives = 97/231 (41%), Gaps = 37/231 (16%)

Query: 105  LSARLLKINE----LQNEVSELQVKLAELLKENKSLKR----LQYRQEKALNKFEDAENE 156
            L A++L +      LQ + + LQ + A+L  EN +L      L  +  + L +    ENE
Sbjct: 1079 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1138

Query: 157  ISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLP 216
             ++ + +   ++ +L + L K  EK     +R       L     +L+   +  E  H  
Sbjct: 1139 -NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR- 1196

Query: 217  ERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQ------RQLLAERKRAYEAHD- 269
            + +D   +L+  + +L+D E+ +K   + + L   + +      ++L  E  R    +  
Sbjct: 1197 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1256

Query: 270  ---ENKVLQKEVQRL-----------------YHKLKEKERELDIKNIYSN 300
               E +VLQ + + L                 + KLKE+ ++LDI +   N
Sbjct: 1257 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1307


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 78/361 (21%), Positives = 166/361 (45%), Gaps = 35/361 (9%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           KI E + ++ E + K+ E  ++ +  +    RQE+ + + E+      ++++    ++  
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAEL 230
           L+E + + +EK R  E+++ + E    + +   +K +E  + R   +R +   K+   E 
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQE----KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 423

Query: 231 KLDDTERRIKELSKNLELSTNSF--QRQLLAERKRAYEAH---DENKVL-QKEVQRLYHK 284
           K+ + E +I+E  K +         Q ++  E KR  +      E K+  Q+E+ R   K
Sbjct: 424 KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK 483

Query: 285 LKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEY 344
           + E+E+    +     +  K    +EK     +    Q +      K  +  E  + +E 
Sbjct: 484 MHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEE------KIREQEEKIREQEE 537

Query: 345 PLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQE 404
            +  +  M  E + E+ G     +Q Q++ R  E      I E+EEK    E+   ++++
Sbjct: 538 KIREQEEMMQEQE-EKMGEQEEKMQEQEKMRRQE----EKIREQEEKI--REQKEKIREQ 590

Query: 405 VEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKR 464
            EK+   WE+EE  ++Q+E   +++ +E+  WE           +  +K+Q E+EE+++R
Sbjct: 591 EEKI---WEQEEKIREQEE---MMQEQEEKMWEQEEKMC-----EQEEKMQ-EQEEKMRR 638

Query: 465 E 465
           +
Sbjct: 639 Q 639



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 89/430 (20%), Positives = 186/430 (43%), Gaps = 65/430 (15%)

Query: 112 INELQNEVSELQVKLAELLKE----NKSLKRLQYRQEKALNKFEDAENE---ISQLIFRH 164
           + +L+ E  +L  +L +  K      ++L  +  +++KA    E+   E   +S  ++R+
Sbjct: 153 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 212

Query: 165 NNEITALKERLRKSQEKERATEKR-------VKDTESELFRTKFSLQKLKEISEARHL-- 215
                 LKE+  K QEK +  E         VK+ + +L R K  L + +  +EA HL  
Sbjct: 213 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 272

Query: 216 ------------PERDDL---------------AKKLVSAELKLDDTERRIKELSKNLEL 248
                        E ++L                +K+   E K+ + E +I+E  + +  
Sbjct: 273 ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIRE 332

Query: 249 STNSFQRQ--LLAER----KRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRL 302
                +RQ  ++ E+    +R  E   E +   + ++ +  + +EK REL+ K     ++
Sbjct: 333 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKI 392

Query: 303 PKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPG 362
            +    +++E  +R+    Q   A +  +  +  E  + E+     + +   E K  E  
Sbjct: 393 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE--QEEKIREQEKKMWRQEEKIHEQE 450

Query: 363 HLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELH----VVKQE------VEKLEDEW 412
            +  + + Q+Q+          I E+EE +   E++H    + KQE       EK+ D+ 
Sbjct: 451 KIREEEKRQEQEEMWRQE--EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE 508

Query: 413 E--REELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAK 470
           E  RE+ +K  +++  + E+EEK   +  + +     +Q  ++  GE+EE+++ +  + +
Sbjct: 509 EKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRR 568

Query: 471 LNEIDRELQD 480
             E  RE ++
Sbjct: 569 QEEKIREQEE 578



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 99/463 (21%), Positives = 193/463 (41%), Gaps = 80/463 (17%)

Query: 35  RSSLVSSSPASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLR 94
           R S ++ +   +   +P+   S G       +K    G         G  S    ++   
Sbjct: 56  RQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASH 115

Query: 95  KDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAE 154
           +  + + +R L A++  I  L  + +ELQ+ L        ++K+L+      +++  D+ 
Sbjct: 116 QHQEAL-RRELEAQVHTIRILTCQKTELQMAL---YYSQHAVKQLEGEARDLISRLHDSW 171

Query: 155 NEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTES---ELFRTKFSLQKLKEISE 211
               +L       ++A+  + +K+   +R  E+  K+ ++   EL+R   + ++LKE   
Sbjct: 172 KFAGEL----EQALSAVATQKKKA---DRYIEELTKERDALSLELYRNTITDEELKE--- 221

Query: 212 ARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDEN 271
                +   L +KL   E +  + +  +KEL + LE +     + LL +++   EA    
Sbjct: 222 -----KNAKLQEKLQLVESEKSEIQLNVKELKRKLERA-----KLLLPQQQLQAEADHLG 271

Query: 272 KVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTK 331
           K LQ    +L  +++E E          NRL     N+++E  + +             +
Sbjct: 272 KELQSVSAKLQAQVEENE--------LWNRL-----NQQQEEKMWRQE-----------E 307

Query: 332 GVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEK 391
            +Q  E+   E+     E I   E K  E        Q +K  R  E      + E+EEK
Sbjct: 308 KIQEWEEKIQEQ----EEKIREQEEKIRE--------QEEKMRRQEEM-----MWEKEEK 350

Query: 392 FVTDEELHVVKQE-VEKLEDE-WEREE----LDKKQKEKASLLEREEKPEWETG------ 439
               EE+   K+E + +LE+  WE+EE    L++K  E+  + E+EEK + E        
Sbjct: 351 MRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 410

Query: 440 RYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSR 482
           R +      +  +K++ +EE+  ++E  + +  E   E +  R
Sbjct: 411 RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR 453



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 19/102 (18%), Positives = 54/102 (52%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           K+   + ++ E + K+ E  ++ +  +   + QE+ + + E+   E  + ++    ++  
Sbjct: 565 KMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCE 624

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEA 212
            +E++++ +EK R  E+++ + E  L + +  +Q+ +E  EA
Sbjct: 625 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 38/240 (15%), Positives = 101/240 (42%), Gaps = 22/240 (9%)

Query: 46  VRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRIL 105
           +R +  K    + ++H Q   +   K     +  R          E +R+  ++  ++  
Sbjct: 432 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR--------QEEKIREQEEIWRQKEK 483

Query: 106 SARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLI---- 161
                KI + + +V   + K+ +  ++ +  +   +RQE+ + + E+   E  + I    
Sbjct: 484 MHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQE 543

Query: 162 --FRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE--ISEARHLPE 217
              +   E    +E   + QEK R  E+++++ E ++   K  +++ +E    +   + E
Sbjct: 544 EMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE 603

Query: 218 RDDL----AKKLVSAELKLDDTERRIKELSKNLELSTNSF--QRQLLAERKRAYEAHDEN 271
           ++++     +K+   E K+ + E +++E  + +         Q   L +++   + H E+
Sbjct: 604 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEH 663


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 78/399 (19%), Positives = 175/399 (43%), Gaps = 24/399 (6%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           KI E + ++ E + K+ E  ++ +  +    RQE+ + + E+      ++++    ++  
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367

Query: 171 LKERLRKSQEKERATEKRVKDTES---ELFRTKFSLQKLKEISEARHLPERDDLAKKLVS 227
            +E + + +EK R  E+ + + E    EL       +K++E  E R   E+    +K   
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 427

Query: 228 AELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKE 287
            E K+   E +I+E  + +        RQ     ++     +E +  Q+E+ R   K+ E
Sbjct: 428 QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHE 487

Query: 288 KERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLT 347
           +E     K     +  K    +EK     +    Q +      + +   E+   E+  + 
Sbjct: 488 QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW 547

Query: 348 PETIMCYENK--WEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEV 405
            E    +E +  WEE      + + +++D+          M R+E+ + ++E  V +QE 
Sbjct: 548 REEEKMHEQEKIWEE------EKRQEQEDK----------MWRQEEKIREQEEKVWRQEE 591

Query: 406 EKLEDEWEREELDKKQ-KEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKR 464
           +  E E +R+E ++K  K++  + E+EEK + +  + +     I+  +++  E+EE++  
Sbjct: 592 KIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGE 651

Query: 465 EMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPE 503
           +    K+ E + ++Q+     +     + + E K+   E
Sbjct: 652 QE--EKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE 688



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 73/411 (17%), Positives = 184/411 (44%), Gaps = 45/411 (10%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           KI E + ++ E + K+ E  ++ +  + + + +E+ + + E+   E  + + R    +  
Sbjct: 315 KIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWE 374

Query: 171 LKERLRKSQEKERATEKRVKDTESELF---RTKFSLQKLKEISEARHLPERDDLAKKLVS 227
            +E++R+ +E     E+++++ E ++    + +   +K +E  + R   +R +   K+  
Sbjct: 375 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 434

Query: 228 AELKLDDTERRIKELSKNL--------------ELSTNSFQRQLLAERKRAYEA------ 267
            E K+ + E +I+E  K +              E      Q ++  + ++ +E       
Sbjct: 435 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQ 494

Query: 268 ----HDENKVLQKEVQRLYHKLKE-KERELDIKNIYSNRLPKSSPNKEKELALRKNAACQ 322
               H++ + ++K+ ++++ + ++ +E+E  I+        +    +E+E   R+     
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMH 554

Query: 323 SDFADLCTKGVQTMEDF---KPEEYPLTPETIMCYENKWEEPGHLTLDLQSQ--KQD--- 374
                   +  Q  ED    + E+     E +   E K  E      + + +  KQ+   
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614

Query: 375 RHGEAGILNP---IMEREEKFVTDEELHVVKQEVEKLEDEWER--EELDKKQKEKASLLE 429
           R  E  I      I E+EEK    EE+   +++ EK+ ++ E+  E+ +K Q+++ ++  
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEM--TQEQEEKMGEQEEKMCEQEEKMQEQEETMWR 672

Query: 430 REEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQD 480
           +EEK   +  + +     I+  +++  E+EE++  +    K+ E + ++Q+
Sbjct: 673 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE--EKMCEQEEKMQE 721



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 72/374 (19%), Positives = 170/374 (45%), Gaps = 40/374 (10%)

Query: 114 ELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKE 173
           E + ++ EL+ K+ E   + K  ++ + RQE+   + ++   E    ++R   +I   +E
Sbjct: 388 EKEEKIRELEEKMHE---QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 444

Query: 174 RLRKSQEK-----------ERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLA 222
           ++R+ ++K           E+  E+  +  + E++R +  + + +EI   R   +  +  
Sbjct: 445 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIW--RQKEKMHEQE 502

Query: 223 KKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLY 282
           +K+   E K+   E +I+E  + +        RQ    R++     +E K+ ++E     
Sbjct: 503 EKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQE----- 557

Query: 283 HKLKEKERELDIKNIYSNRLPKSSPNKEK----ELALRKNAACQSDFADLCTKGVQTMED 338
            K+ E+E+  + ++    +  K    +EK    E  +R+    + +  +   K  + + +
Sbjct: 558 -KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIRE 616

Query: 339 FKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEEL 398
            + E+     E I   E K  E   +T     +++++ GE      + E+EEK    EE 
Sbjct: 617 -QEEKIQEQEEKIREQEEKIREQEEMT----QEQEEKMGEQE--EKMCEQEEKMQEQEET 669

Query: 399 -----HVVKQEVEKLEDEWE--REELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNM 451
                  ++++ +K+ ++ E  RE+ +  Q+++  + E+EEK   +  + Q     ++  
Sbjct: 670 MWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 729

Query: 452 DKLQGEEEERLKRE 465
           ++   E+E RL+++
Sbjct: 730 EEKMWEQEVRLRQQ 743



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 79/380 (20%), Positives = 163/380 (42%), Gaps = 52/380 (13%)

Query: 112 INELQNEVSELQVKLAELLKE----NKSLKRLQYRQEKALNKFEDAENE---ISQLIFRH 164
           + +L+ E  +L  +L +  K      ++L  +  +++KA    E+   E   +S  ++R+
Sbjct: 153 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 212

Query: 165 NNEITALKERLRKSQEKERATEKR-------VKDTESELFRTKFSLQKLKEISEARHLPE 217
                 LKE+  K QEK +  E         VK+ + +L R K  L + +  +EA H   
Sbjct: 213 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADH--- 269

Query: 218 RDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKE 277
              L K+L S   KL        ++ +N EL     Q+Q     ++ +   ++ +  +++
Sbjct: 270 ---LGKELQSVSAKLQ------AQVEEN-ELWNRLNQQQ----EEKMWRQEEKIQEWEEK 315

Query: 278 VQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTME 337
           +Q    K++E+E ++                +E+E  +R+      +  +   +  + M 
Sbjct: 316 IQEQEEKIREQEEKI----------------REQEEKMRRQEEMMWEKEEKMRRQEEMMW 359

Query: 338 DFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEE 397
           + K E+     E +   E K      +  + + + ++   +      I E+EEK   +E+
Sbjct: 360 E-KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 418

Query: 398 LHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGE 457
           +   ++  E+    W +EE  ++Q+EK   +  +EK  W           I+  +K Q E
Sbjct: 419 IREQEKRQEQEAKMWRQEEKIREQEEK---IREQEKKMWRQEEKIHEQEKIREEEKRQ-E 474

Query: 458 EEERLKREMLLAKLNEIDRE 477
           +EE  ++E  + +  EI R+
Sbjct: 475 QEEMWRQEEKIHEQEEIWRQ 494



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 27/135 (20%), Positives = 68/135 (50%), Gaps = 9/135 (6%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           KI E + ++ E + K+ E  +  +  +     QE+ + + E+   E  + ++R   +I  
Sbjct: 620 KIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIRE 679

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSL----QKLKEISEARHLPERDDLAKKLV 226
            ++++R+ +EK R  E+ +++ E +++  +  +    +K++E  E     E     +K+ 
Sbjct: 680 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE-----EKMW 734

Query: 227 SAELKLDDTERRIKE 241
             E++L   E +++E
Sbjct: 735 EQEVRLRQQEEKMQE 749



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 32/182 (17%), Positives = 88/182 (48%), Gaps = 19/182 (10%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           KI E + +V   + K+ E  ++ +  +   ++QE+ + + E+   E          +I  
Sbjct: 578 KIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQE-------QEEKIRE 630

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAEL 230
            +E++R+ +E  +  E+++ + E ++   +   +K++E  E     E     +K+   E 
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQE---EKMQEQEETMWRQE-----EKIREQEK 682

Query: 231 KLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKER 290
           K+ + E +I+E  + ++      + ++  + ++  E  ++ +  +++++R   K+ E+E 
Sbjct: 683 KIREQEEKIREQEEMMQ----EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV 738

Query: 291 EL 292
            L
Sbjct: 739 RL 740


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 90/438 (20%), Positives = 196/438 (44%), Gaps = 54/438 (12%)

Query: 99  LVTKRILSARLLKINELQ----NEVSELQVKLAELLKENKSLK-RLQ--YRQEKALNKFE 151
           LV+K+ L  RL+++ E +    N+   LQ+++ ++L++N++LK ++Q  + Q  A     
Sbjct: 540 LVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSAS 599

Query: 152 DAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISE 211
               E+ ++I   + +I   ++ L   +++  + E+ +KD ++  F  K  +QKL+    
Sbjct: 600 VLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA--- 656

Query: 212 ARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDEN 271
                    LA +  +A  +L+  ++ +      + L     Q ++  + +     +D+N
Sbjct: 657 ---------LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707

Query: 272 KVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTK 331
           K L+ EVQ+L   + E+  +  ++     ++ K    K+++L   +    ++    + TK
Sbjct: 708 KALKSEVQKLQTLVSEQPNKDVVE-----QMEKCIQEKDEKLKTVEE-LLETGLIQVATK 761

Query: 332 GVQTMEDFKPEEYPLTPET--IMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMERE 389
             + +   + E   LT E   +   +N       L  +L+    ++ G+   +  ++E E
Sbjct: 762 -EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820

Query: 390 EKFVTDEELHV--VKQEVEKLEDEWEREELDKKQ-----------------KEK-----A 425
              V ++E  V  +KQE++ L++E    +L+K Q                 KE+      
Sbjct: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 880

Query: 426 SLLEREEKPEWETGRYQLGMYPIQNMDKLQGEE--EERLKREMLLAKLNEIDRELQDSRN 483
           ++LE +EK    TG++   +       K   +E  +  LK     ++  E++  L++  N
Sbjct: 881 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 940

Query: 484 LKYPVLPLLPDFESKLHS 501
               +  +L + ES L S
Sbjct: 941 ELKRLEAMLKERESDLSS 958



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 92/453 (20%), Positives = 190/453 (41%), Gaps = 80/453 (17%)

Query: 102  KRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLI 161
            + +L A LLK+   +  V +L+ ++  L +E  +++  + +Q    +K ++ +N    L+
Sbjct: 814  EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQN----LL 869

Query: 162  FRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE--ISEARHLPERD 219
                 ++  +K  L + ++    T K ++D + E    K  +Q++ +  + EA    + +
Sbjct: 870  KGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFE 929

Query: 220  DLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQ 279
            +L   L   E +L   E  +KE   +L   T   Q           +  DENK+ + +++
Sbjct: 930  ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQ-----------DVQDENKLFKSQIE 978

Query: 280  RLYHK-----------------LKEKEREL--------DIKNIYSNRLPKSSPNKEKEL- 313
            +L  +                 + E+E+E+         +K+   ++  K++  +EK   
Sbjct: 979  QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWE 1038

Query: 314  ALRKNAACQSDFADLCTK-------GVQTME-DFKPEEYPLTP-----------ETIMCY 354
            A+   A+ +    D   K        V+ +E + K     L P           E +  +
Sbjct: 1039 AMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGF 1098

Query: 355  ENKWEEPGHLTLDLQSQKQDRH--GEAGILNPIMERE-EKF-----VTDEELHVVKQEVE 406
            E K +E    T   +  K   H   EA  ++ +++ E EK+      T+  L  +++ VE
Sbjct: 1099 EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1158

Query: 407  KLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREM 466
            + E++W + ++D+  K    +       E E  R +     I+N+ +    E E L+ E+
Sbjct: 1159 QEENKW-KVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR----EREHLEMEL 1213

Query: 467  LLAKLNEIDRELQDSRNLKYPVLPLLPDFESKL 499
              A++ E    + + R LK     LL + + KL
Sbjct: 1214 EKAEM-ERSTYVTEVRELK----DLLTELQKKL 1241



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 73/383 (19%), Positives = 144/383 (37%), Gaps = 51/383 (13%)

Query: 103  RILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFED-AENEISQLI 161
            +++S R  +I+ L NE+  L+  +    K+N  L+   +   +AL   E   ++++++  
Sbjct: 999  KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTS 1058

Query: 162  FRHNNEITAL----KERLRKSQEKE------------RATEKRVKDT---ESELFRTKFS 202
                 ++ A+    KE L+K   K                EK+ K+     S     K  
Sbjct: 1059 KERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL 1118

Query: 203  LQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERK 262
              KLKE  E   L + +    K V AE     TE  +++L +++E   N ++ ++    K
Sbjct: 1119 EHKLKEADEMHTLLQLECEKYKSVLAE-----TEGILQKLQRSVEQEENKWKVKVDESHK 1173

Query: 263  RAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQ 322
               +        ++E++RL      +    DI+N+   R       ++ E+         
Sbjct: 1174 TIKQMQSSFTSSEQELERL------RSENKDIENLRREREHLEMELEKAEMERSTYVTEV 1227

Query: 323  SDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGIL 382
             +  DL T+  + ++D   E      E  +       +       L++++ +R   AG  
Sbjct: 1228 RELKDLLTELQKKLDDSYSEAVRQNEELNLLK----AQLNETLTKLRTEQNERQKVAG-- 1281

Query: 383  NPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQ 442
                          +LH  +Q +E ++ +  +   D    E + +    E  E ET    
Sbjct: 1282 --------------DLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVS 1327

Query: 443  LGMYPIQNMDKLQGEEEERLKRE 465
            L     Q    LQ   ++  K +
Sbjct: 1328 LNQTVTQLQQLLQAVNQQLTKEK 1350


>gi|118498368 kinectin 1 isoform c [Homo sapiens]
          Length = 1300

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 90/438 (20%), Positives = 196/438 (44%), Gaps = 54/438 (12%)

Query: 99  LVTKRILSARLLKINELQ----NEVSELQVKLAELLKENKSLK-RLQ--YRQEKALNKFE 151
           LV+K+ L  RL+++ E +    N+   LQ+++ ++L++N++LK ++Q  + Q  A     
Sbjct: 540 LVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSAS 599

Query: 152 DAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISE 211
               E+ ++I   + +I   ++ L   +++  + E+ +KD ++  F  K  +QKL+    
Sbjct: 600 VLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA--- 656

Query: 212 ARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDEN 271
                    LA +  +A  +L+  ++ +      + L     Q ++  + +     +D+N
Sbjct: 657 ---------LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707

Query: 272 KVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTK 331
           K L+ EVQ+L   + E+  +  ++     ++ K    K+++L   +    ++    + TK
Sbjct: 708 KALKSEVQKLQTLVSEQPNKDVVE-----QMEKCIQEKDEKLKTVEE-LLETGLIQVATK 761

Query: 332 GVQTMEDFKPEEYPLTPET--IMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMERE 389
             + +   + E   LT E   +   +N       L  +L+    ++ G+   +  ++E E
Sbjct: 762 -EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820

Query: 390 EKFVTDEELHV--VKQEVEKLEDEWEREELDKKQ-----------------KEK-----A 425
              V ++E  V  +KQE++ L++E    +L+K Q                 KE+      
Sbjct: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 880

Query: 426 SLLEREEKPEWETGRYQLGMYPIQNMDKLQGEE--EERLKREMLLAKLNEIDRELQDSRN 483
           ++LE +EK    TG++   +       K   +E  +  LK     ++  E++  L++  N
Sbjct: 881 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 940

Query: 484 LKYPVLPLLPDFESKLHS 501
               +  +L + ES L S
Sbjct: 941 ELKRLEAMLKERESDLSS 958



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 86/435 (19%), Positives = 172/435 (39%), Gaps = 100/435 (22%)

Query: 102  KRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLI 161
            + +L A LLK+   +  V +L+ ++  L +E  +++  + +Q    +K ++ +N    L+
Sbjct: 814  EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQN----LL 869

Query: 162  FRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE--ISEARHLPERD 219
                 ++  +K  L + ++    T K ++D + E    K  +Q++ +  + EA    + +
Sbjct: 870  KGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFE 929

Query: 220  DLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQ 279
            +L   L   E +L   E  +KE   +L   T   Q           +  DENK+ + +++
Sbjct: 930  ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQ-----------DVQDENKLFKSQIE 978

Query: 280  RLYHK-----------------LKEKEREL--------DIKNIYSNRLPKSSPNKEKELA 314
            +L  +                 + E+E+E+         +K+   ++  K++  +++  A
Sbjct: 979  QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEA 1038

Query: 315  LRKNA-----------ACQSDF------------ADLCTKGVQTMEDFKPEEYPLTPETI 351
            +   A           +  S+             A  C  G    E+ K  E+ L     
Sbjct: 1039 VELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKL----- 1093

Query: 352  MCYENKWEEPGHLTLDLQSQK-----QDRHGEAGILNPIMEREE---KFVTDEELHVVK- 402
                 K  +  H  L L+ +K      +  G    L   +E+EE   K   DE    +K 
Sbjct: 1094 -----KEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQ 1148

Query: 403  ---------QEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRY-----QLGMYPI 448
                     QE+E+L    E ++++  ++E+  L    EK E E   Y     +L     
Sbjct: 1149 MQSSFTSSEQELERLRS--ENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLN 1206

Query: 449  QNMDKLQGEEEERLK 463
            + + KL+ E+ ER K
Sbjct: 1207 ETLTKLRTEQNERQK 1221



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 75/379 (19%), Positives = 145/379 (38%), Gaps = 59/379 (15%)

Query: 105  LSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRH 164
            LS++   + ++Q+E    + ++ +L ++N          E+ L    + E EIS L    
Sbjct: 956  LSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLW--- 1012

Query: 165  NNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKK 224
             NE+ +LK+ +   ++K    +++V+  E E    K  L+KL                K 
Sbjct: 1013 -NELDSLKDAVEHQRKKNNERQQQVEAVELE---AKEVLKKL--------------FPKV 1054

Query: 225  LVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHK 284
             V + L   +     ++ +K     T+  +   + E K   EA + + +LQ E ++    
Sbjct: 1055 SVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHK-LKEADEMHTLLQLECEKYKSV 1113

Query: 285  LKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAA------CQSDFADLCTKGVQTMED 338
            L E E  L        +L +S   +E +  ++ + +       QS F    T   Q +E 
Sbjct: 1114 LAETEGIL-------QKLQRSVEQEENKWKVKVDESHKTIKQMQSSF----TSSEQELER 1162

Query: 339  FKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPI------------M 386
             + E   +        EN   E  HL ++L+  + +R      +  +             
Sbjct: 1163 LRSENKDI--------ENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRT 1214

Query: 387  EREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMY 446
            E+ E+     +LH  +Q +E ++ +  +   D    E + +    E  E ET    L   
Sbjct: 1215 EQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQT 1274

Query: 447  PIQNMDKLQGEEEERLKRE 465
              Q    LQ   ++  K +
Sbjct: 1275 VTQLQQLLQAVNQQLTKEK 1293


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 90/438 (20%), Positives = 196/438 (44%), Gaps = 54/438 (12%)

Query: 99  LVTKRILSARLLKINELQ----NEVSELQVKLAELLKENKSLK-RLQ--YRQEKALNKFE 151
           LV+K+ L  RL+++ E +    N+   LQ+++ ++L++N++LK ++Q  + Q  A     
Sbjct: 540 LVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSAS 599

Query: 152 DAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISE 211
               E+ ++I   + +I   ++ L   +++  + E+ +KD ++  F  K  +QKL+    
Sbjct: 600 VLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA--- 656

Query: 212 ARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDEN 271
                    LA +  +A  +L+  ++ +      + L     Q ++  + +     +D+N
Sbjct: 657 ---------LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707

Query: 272 KVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTK 331
           K L+ EVQ+L   + E+  +  ++     ++ K    K+++L   +    ++    + TK
Sbjct: 708 KALKSEVQKLQTLVSEQPNKDVVE-----QMEKCIQEKDEKLKTVEE-LLETGLIQVATK 761

Query: 332 GVQTMEDFKPEEYPLTPET--IMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMERE 389
             + +   + E   LT E   +   +N       L  +L+    ++ G+   +  ++E E
Sbjct: 762 -EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820

Query: 390 EKFVTDEELHV--VKQEVEKLEDEWEREELDKKQ-----------------KEK-----A 425
              V ++E  V  +KQE++ L++E    +L+K Q                 KE+      
Sbjct: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 880

Query: 426 SLLEREEKPEWETGRYQLGMYPIQNMDKLQGEE--EERLKREMLLAKLNEIDRELQDSRN 483
           ++LE +EK    TG++   +       K   +E  +  LK     ++  E++  L++  N
Sbjct: 881 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 940

Query: 484 LKYPVLPLLPDFESKLHS 501
               +  +L + ES L S
Sbjct: 941 ELKRLEAMLKERESDLSS 958



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 92/453 (20%), Positives = 190/453 (41%), Gaps = 80/453 (17%)

Query: 102  KRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLI 161
            + +L A LLK+   +  V +L+ ++  L +E  +++  + +Q    +K ++ +N    L+
Sbjct: 814  EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQN----LL 869

Query: 162  FRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE--ISEARHLPERD 219
                 ++  +K  L + ++    T K ++D + E    K  +Q++ +  + EA    + +
Sbjct: 870  KGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFE 929

Query: 220  DLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQ 279
            +L   L   E +L   E  +KE   +L   T   Q           +  DENK+ + +++
Sbjct: 930  ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQ-----------DVQDENKLFKSQIE 978

Query: 280  RLYHK-----------------LKEKEREL--------DIKNIYSNRLPKSSPNKEKEL- 313
            +L  +                 + E+E+E+         +K+   ++  K++  +EK   
Sbjct: 979  QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWE 1038

Query: 314  ALRKNAACQSDFADLCTK-------GVQTME-DFKPEEYPLTP-----------ETIMCY 354
            A+   A+ +    D   K        V+ +E + K     L P           E +  +
Sbjct: 1039 AMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGF 1098

Query: 355  ENKWEEPGHLTLDLQSQKQDRH--GEAGILNPIMERE-EKF-----VTDEELHVVKQEVE 406
            E K +E    T   +  K   H   EA  ++ +++ E EK+      T+  L  +++ VE
Sbjct: 1099 EKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVE 1158

Query: 407  KLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREM 466
            + E++W + ++D+  K    +       E E  R +     I+N+ +    E E L+ E+
Sbjct: 1159 QEENKW-KVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR----EREHLEMEL 1213

Query: 467  LLAKLNEIDRELQDSRNLKYPVLPLLPDFESKL 499
              A++ E    + + R LK     LL + + KL
Sbjct: 1214 EKAEM-ERSTYVTEVRELK----DLLTELQKKL 1241



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 73/383 (19%), Positives = 144/383 (37%), Gaps = 51/383 (13%)

Query: 103  RILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFED-AENEISQLI 161
            +++S R  +I+ L NE+  L+  +    K+N  L+   +   +AL   E   ++++++  
Sbjct: 999  KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTS 1058

Query: 162  FRHNNEITAL----KERLRKSQEKE------------RATEKRVKDT---ESELFRTKFS 202
                 ++ A+    KE L+K   K                EK+ K+     S     K  
Sbjct: 1059 KERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL 1118

Query: 203  LQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERK 262
              KLKE  E   L + +    K V AE     TE  +++L +++E   N ++ ++    K
Sbjct: 1119 EHKLKEADEMHTLLQLECEKYKSVLAE-----TEGILQKLQRSVEQEENKWKVKVDESHK 1173

Query: 263  RAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQ 322
               +        ++E++RL      +    DI+N+   R       ++ E+         
Sbjct: 1174 TIKQMQSSFTSSEQELERL------RSENKDIENLRREREHLEMELEKAEMERSTYVTEV 1227

Query: 323  SDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGIL 382
             +  DL T+  + ++D   E      E  +       +       L++++ +R   AG  
Sbjct: 1228 RELKDLLTELQKKLDDSYSEAVRQNEELNLLK----AQLNETLTKLRTEQNERQKVAG-- 1281

Query: 383  NPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQ 442
                          +LH  +Q +E ++ +  +   D    E + +    E  E ET    
Sbjct: 1282 --------------DLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVS 1327

Query: 443  LGMYPIQNMDKLQGEEEERLKRE 465
            L     Q    LQ   ++  K +
Sbjct: 1328 LNQTVTQLQQLLQAVNQQLTKEK 1350


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 101/504 (20%), Positives = 208/504 (41%), Gaps = 52/504 (10%)

Query: 28   ETPQSSGRSSLVSSSPASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQS 87
            E P+   R  L+ S     RR+   R+    +   +  R+   + L  R  ++     + 
Sbjct: 623  EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR--LKREHEEER 680

Query: 88   LNREPLRKDTDLVTKRILSARLLKIN-ELQNEVSELQVKLAELLKENKSLKRLQYRQEKA 146
              +E   ++ +   +RI S R+ K   +L++E    Q K+    ++ +  +R Q ++EK 
Sbjct: 681  REQELAEEEQEQARERIKS-RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR 739

Query: 147  LNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKL 206
              +  + + +  +   R   E    +E+ R    + +A EK  +  +    R     Q+ 
Sbjct: 740  RRRESELQWQEEERAHRQQQE----EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795

Query: 207  KEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYE 266
            +++       ER    ++ +  E + +   R+ +E  K L+      Q Q    R+RA +
Sbjct: 796  RQL----RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ---RRERAQQ 848

Query: 267  AHDENKVLQKEVQRLYHKLK----------EKERELDIKNIYSNRLPKSSPNKEKELALR 316
              +E   LQ++ +R   + +          E+ER+     +Y+    +    KE++L   
Sbjct: 849  LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908

Query: 317  KNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRH 376
            +    Q +  +   +  Q  +  + E+     E ++  E +           + ++Q+R 
Sbjct: 909  EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREERE-----------KRRRQERE 957

Query: 377  GEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEK--- 433
             +      + ++EE+ + +E     +QE EK      REE + +Q+E+  L E  EK   
Sbjct: 958  RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY----REEEELQQEEEQLLREEREKRRR 1013

Query: 434  PEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLP 493
             EWE           +  D+LQ EEE+ L+ E    +L E +R+ ++   L+     LL 
Sbjct: 1014 QEWER--------QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065

Query: 494  DFESKLHSPERSPKTYRFSESSER 517
            + E +    +   + YR  E  ++
Sbjct: 1066 E-ERETRRRQELERQYRKEEELQQ 1088



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 97/424 (22%), Positives = 186/424 (43%), Gaps = 40/424 (9%)

Query: 105  LSAR--LLKINELQNEVSELQVKLAELL--KENKSLKRLQYRQEKALNKFEDAENEISQL 160
            LSAR  L +  E Q    E Q +    L  +E K  +R Q R+ +   +F + E ++ + 
Sbjct: 784  LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRR 843

Query: 161  IFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARH-LPERD 219
                  ++   ++ L++ QE+ R+ E+R           K+  Q  +E    RH L  + 
Sbjct: 844  --ERAQQLQEEEDGLQEDQERRRSQEQRRDQ--------KWRWQLEEERKRRRHTLYAKP 893

Query: 220  DLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQ 279
             L ++L   +  L + E          EL     +++   E++R Y    E + LQ+E +
Sbjct: 894  ALQEQLRKEQQLLQEEEE---------ELQREEREKRRRQEQERQYR---EEEQLQQEEE 941

Query: 280  RLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDF 339
            +L  + +EK R  + +  Y  R  K    KE++L   +    +    +   +  + ++  
Sbjct: 942  QLLREEREKRRRQERERQY--RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ-- 997

Query: 340  KPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELH 399
            + EE  L  E       +WE       +LQ +++    E      + ERE ++  +EEL 
Sbjct: 998  QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ 1057

Query: 400  VVKQEVEKLEDEWE---REELDKKQKEKASLLEREE---KPEWETGRYQLGMYPIQNMDK 453
              ++E + L +E E   R+EL+++ +++  L + EE   + E E  R Q      +  ++
Sbjct: 1058 --QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE 1115

Query: 454  LQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRFSE 513
            LQ EEE+ L+ E    +  E++R+ ++   ++     LL +   K    E   + YR  E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE-RQYREEE 1174

Query: 514  SSER 517
              ++
Sbjct: 1175 ELQQ 1178



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 112/520 (21%), Positives = 208/520 (40%), Gaps = 90/520 (17%)

Query: 48   RKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSA 107
            RK+ K Q  + Q+  + P K   +     K  R     Q    + LR++ +   ++    
Sbjct: 961  RKDKKLQQKEEQLLGEEPEKRRRQ--EREKKYREEEELQQEEEQLLREEREKRRRQEWER 1018

Query: 108  RLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNE 167
            +  K +ELQ E  +L       L+E +  +RLQ R E+   + E+ + E  QL+      
Sbjct: 1019 QYRKKDELQQEEEQL-------LREEREKRRLQER-ERQYREEEELQQEEEQLLGEER-- 1068

Query: 168  ITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVS 227
                + R R+  E++   E+ ++  E +L         L+E  E R   ER+   ++   
Sbjct: 1069 ----ETRRRQELERQYRKEEELQQEEEQL---------LREEPEKRRRQERERQCREEEE 1115

Query: 228  AELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKE 287
             + + +   R  +E  +  EL     + + + + +      +  K  ++E++R Y     
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQY----R 1171

Query: 288  KERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFK----PE- 342
            +E EL  +     R  +    +E+E   R+    Q        +      D K    PE 
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231

Query: 343  EYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEK----------- 391
            E  +    + C   + E+   L     SQ +DR  +  + + + E++E+           
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLE---DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQ 1288

Query: 392  ----FVTDEELHVVKQEV----------------EKLEDEWEREELDKKQKEKASLL-ER 430
                F  +E+L   +Q+                 E+ E++  R+E D+K +E+  LL ER
Sbjct: 1289 RDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER 1348

Query: 431  EEKP-----------EWETGRYQLGMYPIQNMDKLQGEEEER--LKREMLLAKLNEIDRE 477
            EE+P           E E    + G   ++   +L+ +E ER  LK E  L +  E +++
Sbjct: 1349 EEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL-RCQEREQQ 1407

Query: 478  LQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSER 517
            L+  R+ K+       + E +L   ER  K +R  E   R
Sbjct: 1408 LRQDRDRKF------REEEQQLSRQERDRK-FREEEQQVR 1440



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 99/461 (21%), Positives = 193/461 (41%), Gaps = 52/461 (11%)

Query: 84  RSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLK------ENKSLK 137
           R Q L RE   +  D + KR    R  ++   Q E  E ++K  E+ +        + LK
Sbjct: 563 REQRLKREQEER-RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621

Query: 138 RLQYRQEKA--LNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESE 195
           R +  +E+   L K E+ E    Q + R   E    ++RL++ +E+ER  ++  ++ E E
Sbjct: 622 REEPEEERRQQLLKSEEQEERRQQQLRREQQE--RREQRLKREEEEERLEQRLKREHEEE 679

Query: 196 LFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLD-DTERRIKELSKNLELSTNSFQ 254
                   ++ +E++E      R+ +  ++   + +L+ + + R  ++           +
Sbjct: 680 --------RREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731

Query: 255 RQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELA 314
           RQ   E++R      E+++  +E +R + + +E+E+  D    +  +  + S    + L+
Sbjct: 732 RQEQEEKRR----RRESELQWQEEERAHRQQQEEEQRRDFT--WQWQAEEKSERGRQRLS 785

Query: 315 LRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQD 374
            R     Q +      +  Q  + F PEE           E + +E   L  + Q Q+++
Sbjct: 786 ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE-KELQFLEEEEQLQRRE 844

Query: 375 RHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQ------------- 421
           R  +      + E E+    D+E    +++    +  W+ EE  K++             
Sbjct: 845 RAQQ------LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ 898

Query: 422 --KEKASLLEREE---KPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDR 476
             KE+  L E EE   + E E  R Q      +  ++LQ EEE+ L+ E    +  E +R
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958

Query: 477 ELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSER 517
           + +  + L+     LL +   K    ER  K YR  E  ++
Sbjct: 959 QYRKDKKLQQKEEQLLGEEPEKRRRQERE-KKYREEEELQQ 998



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 87/483 (18%), Positives = 208/483 (43%), Gaps = 54/483 (11%)

Query: 12  QERKAGKHHYSYLSDFETPQSSGRSSLVSSSPASVRRKN------PKRQTSDGQVHHQAP 65
           +ER+A +         ET +      L       +RRK        +R+  D     +  
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243

Query: 66  RKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVK 125
           ++   +    RK        +   +  L+++ + + K  L  + L+    + E  + +++
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK--LERQELRRERQEEEQQQQRLR 301

Query: 126 LAELLKENKSLKRLQYRQEKA--LNKFEDAENEISQLIFRHNNEITALKERLRKSQEKER 183
             + L+  +  +R + ++E+     + E  E    Q + R   E    +++LR+ QE+ER
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE--RREQQLRREQEEER 359

Query: 184 ATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELS 243
             ++  ++ E E  R +  L++ +++   + L     L ++    +L+ +   RR ++L 
Sbjct: 360 REQQLRREQEEE--RREQQLRREQQLRREQQLRREQQLRRE---QQLRREQQLRREQQLR 414

Query: 244 KNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLP 303
           +  +L     +R+    R++  E H++    ++  QRL  K +++ER         + L 
Sbjct: 415 REQQL-----RREQQLRREQEEERHEQKHEQERREQRL--KREQEERR--------DWLK 459

Query: 304 KSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGH 363
           +    +  E   RK    +    +   + ++  E+ + E+     + +   + +  E   
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQR- 518

Query: 364 LTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKE 423
               L+ Q+++   +  + +    R E+    E+L + ++E ++LE E   + L ++Q+E
Sbjct: 519 ----LKRQEEEERLQQRLRSEQQLRREQEERREQL-LKREEEKRLEQERREQRLKREQEE 573

Query: 424 KAS-LLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSR 482
           +   LL+REE+               +   +L+ E+EERL++ +   ++  +++E +  +
Sbjct: 574 RRDQLLKREEE---------------RRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618

Query: 483 NLK 485
            LK
Sbjct: 619 RLK 621



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 91/407 (22%), Positives = 173/407 (42%), Gaps = 35/407 (8%)

Query: 84  RSQSLNREP--------LRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKS 135
           R Q L RE         LR++ +   +     R  ++   Q    E Q++  + L+  + 
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 406

Query: 136 LKR-LQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTE- 193
           L+R  Q R+E+ L + +    E  +      +E    ++RL++ QE+ R   KR ++TE 
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER 466

Query: 194 SELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSF 253
            E  R K  L++ +E        ER +   KL   E + +  ERR ++L +  E      
Sbjct: 467 HEQERRKQQLKRDQE-------EERRERWLKLEEEE-RREQQERREQQLRREQEERREQR 518

Query: 254 QRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKEL 313
            ++   E +       E ++ +++ +R    LK +E +   +     RL +    +  +L
Sbjct: 519 LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578

Query: 314 ALRKNAACQSDFADLCTKGVQTMEDFKPEEYP-LTPETIMCYENKWEEPGHLTLD--LQS 370
             R+    Q        + ++  +  K EE   L  E       K EEP        L+S
Sbjct: 579 LKREEERRQQRLKREQEERLE--QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKS 636

Query: 371 QKQDRHGEAGILNPIME-REEKFVTDEELHVVKQEVEKLEDEWERE-ELDKKQKEKASLL 428
           ++Q+   +  +     E RE++   +EE   ++Q +++  +E  RE EL ++++E+A   
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696

Query: 429 EREEKPEW------ETGRYQLGMY----PIQNMDKLQGEEEERLKRE 465
            +   P+W      E    Q  +Y      +   + Q +EE+R +RE
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 110/472 (23%), Positives = 199/472 (42%), Gaps = 56/472 (11%)

Query: 71   KGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELL 130
            K L   + +R   R Q L ++  RK  +   +     R  K  E      E QV+  E  
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE-----EEQQVRRQE-- 1443

Query: 131  KENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVK 190
            +E K L+  Q  +++   KF + E    QL+     +    +ER RK  E+E+   ++ +
Sbjct: 1444 RERKFLEEEQQLRQERHRKFREEE----QLLQEREEQQLHRQERDRKFLEEEQQLRRQER 1499

Query: 191  DT---ESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTER-------RIK 240
            D    E EL R++   +K  E  +  H  +R    +K +  E +L   ER       R +
Sbjct: 1500 DRKFREQEL-RSQEPERKFLEEEQQLHRQQRQ---RKFLQEEQQLRRQERGQQRRQDRDR 1555

Query: 241  ELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSN 300
            +  +  +L     ++QL  + +      +E KV ++E +R   K  E E++L  +     
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER---KFMEDEQQLRRQEGQQQ 1612

Query: 301  -RLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWE 359
             R  +    +E E  L++    Q    +   K ++     + +E     +     + K+ 
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE--QQLRHDRDRKFR 1670

Query: 360  EPGHLTLD-----LQSQKQDRH-GEAGILNPIMEREEKFVTDE------ELHVVKQEVEK 407
            E   L  +     L+ Q++DR   E        ERE KF+ +E      EL    +E E+
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730

Query: 408  LEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMD-KLQGEEEERLKREM 466
            L  E E+E+L ++++ +  L E + +PE E  + +      Q  D K + EE+ R +RE 
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR-----QERDRKFREEEQLRQEREE 1785

Query: 467  LLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSERL 518
               +  E DR+ ++   L+        + E +   P++    YR+ E   +L
Sbjct: 1786 QQLRSQESDRKFREEEQLR-------QEREEQQLRPQQRDGKYRWEEEQLQL 1830



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 79/375 (21%), Positives = 162/375 (43%), Gaps = 50/375 (13%)

Query: 137  KRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESEL 196
            ++L+  ++K   + +    E  QL+     E    K R +++  K R  E+ +++ E + 
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREE----KRRRQETDRKFREEEQLLQEREEQP 1352

Query: 197  FRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQ 256
             R +   +K +E  E RH     +  +K +  E +L   ER  K L +  +L     ++Q
Sbjct: 1353 LRRQERDRKFRE-EELRH----QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407

Query: 257  LLAERKRAYEAHDENKVLQKEVQRLYHK----LKEKERELD-IKNIYSNRLPKSSPNKEK 311
            L  +R R +   +E ++ ++E  R + +    ++ +ERE   ++     R  +    +E+
Sbjct: 1408 LRQDRDRKFR-EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466

Query: 312  ELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLD---- 367
            E  L++    Q    +   K ++  +  + +E           E + +EP    L+    
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQE---RDRKFREQELRSQEPERKFLEEEQQ 1523

Query: 368  ----------LQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWER--- 414
                      LQ ++Q R  E G      +R+ KF  +E+L   ++E +    E +R   
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQQRR-QDRDRKFREEEQLRQEREEQQLSRQERDRKFR 1582

Query: 415  --EELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDK--------LQGEEEERLKR 464
              E+  ++Q+++   +E E++   + G+ QL     Q  D+        LQ  EE++L R
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR----QERDRKFREDEQLLQEREEQQLHR 1638

Query: 465  EMLLAKLNEIDRELQ 479
            +    K  E + +L+
Sbjct: 1639 QERDRKFLEEEPQLR 1653



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 78/333 (23%), Positives = 145/333 (43%), Gaps = 35/333 (10%)

Query: 115  LQNEVSELQVKLAELLKENKSLKRL----QYRQEKALNKFEDAENEISQLIFRHNNEITA 170
            L+ +    Q +  + +++ + L+R     Q RQE+   KF + E    QL+     +   
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD-RKFREDE----QLLQEREEQQLH 1637

Query: 171  LKERLRKSQEKE-----RATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKL 225
             +ER RK  E+E     +  E++++      FR +  L +  E  + R   ERD   +K 
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR-QERD---RKF 1693

Query: 226  VSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKL 285
               E +L   ER  K L +  +L     +R+   E +   E   E    Q   Q  Y K+
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE----QLRRQERYRKI 1749

Query: 286  KEKER---ELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPE 342
             E+E+   E + + +      +    +E+    R+    +S  +D   +  + +   + E
Sbjct: 1750 LEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER-E 1808

Query: 343  EYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVK 402
            E  L P+     + +WEE     L L+ Q+Q    E    +     EE+F T E+    +
Sbjct: 1809 EQQLRPQQ-RDGKYRWEEE---QLQLEEQEQRLRQER---DRQYRAEEQFATQEKSRREE 1861

Query: 403  QEVEKLEDEWEREELDKKQKEKASLLEREEKPE 435
            QE+ + E++  R+E ++K +E+   + R++K E
Sbjct: 1862 QELWQEEEQKRRQERERKLREEH--IRRQQKEE 1892



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 68/349 (19%), Positives = 149/349 (42%), Gaps = 55/349 (15%)

Query: 142 RQEKALNKFEDAENEISQLIFRHNNEITALKERL-----RKSQEKERATEKRVKDTESEL 196
           RQE+   +FE  + ++ +   +   +    +ER       +S+++ER  ++  +  + EL
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEEL 173

Query: 197 FRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQ 256
           +R +   Q+ +E  E R   E+    K   + E   D+ + R +EL +         Q+Q
Sbjct: 174 WRQR---QEWQEREERRAEEEQLQSCKGHETEEFP-DEEQLRRRELLELRRKGREEKQQQ 229

Query: 257 LLAERKRAYEAHDENK------VLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKE 310
               + R ++  +E +      VL+KE ++L  +  +++REL  +     +L +    +E
Sbjct: 230 RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289

Query: 311 KELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQS 370
           ++                  +  Q  +  + E+             K EE      + + 
Sbjct: 290 RQ------------------EEEQQQQRLRREQQ---------LRRKQEE------ERRE 316

Query: 371 QKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLER 430
           Q+++R  +        ER E+     E  + +++ E+ E +  RE+ +++++++    + 
Sbjct: 317 QQEERREQ-------QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE 369

Query: 431 EEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQ 479
           EE+ E +  R Q      Q   + Q   E++L+RE  L +  ++ RE Q
Sbjct: 370 EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 87/397 (21%), Positives = 157/397 (39%), Gaps = 42/397 (10%)

Query: 118 EVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRK 177
           E SE Q +L +  ++ +  +  + RQE    +   AE E  Q    H  E    +E+LR+
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212

Query: 178 -------------SQEKERATEKRVKDTESE---------LFRTKFSLQKLKEISEARHL 215
                         Q++ R  + RV   E E         L + +  LQ+ +E    R L
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE-EEPQRQREL 271

Query: 216 PERDDLAKKLVSAELKLDDTE--------RRIKELSKNLELSTNSFQ--RQLLAERKRAY 265
            E ++  +KL   EL+ +  E        RR ++L +  E      Q  R+   ER+   
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331

Query: 266 EAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDF 325
           E   E ++ +++ +R   +L+ ++ E         +L +    + +E  LR+    + + 
Sbjct: 332 EERREQQLRREQEERREQQLRREQEE----ERREQQLRREQEEERREQQLRREQQLRRE- 386

Query: 326 ADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPI 385
             L  +     E     E  L  E  +  E +      L  + + ++ ++  E       
Sbjct: 387 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR 446

Query: 386 MEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGM 445
           ++RE+    +E    +K+E E    E ER +   K+ ++    ER  K E E  R Q   
Sbjct: 447 LKREQ----EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502

Query: 446 YPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSR 482
              Q   + +   E+RLKR+    +L +  R  Q  R
Sbjct: 503 REQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 79/406 (19%), Positives = 165/406 (40%), Gaps = 53/406 (13%)

Query: 114  ELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKE 173
            +L+ E  E Q+   E  ++ +  ++   RQE+     ED      Q + R   +    +E
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED-----EQQLRRQEGQQQLRQE 1616

Query: 174  RLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPE----RDDLAKKLVSAE 229
            R RK +E E+  ++R    E +L R +   + L+E  + R        R D  +K    E
Sbjct: 1617 RDRKFREDEQLLQER---EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE 1673

Query: 230  LKLDDTER---RIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLK 286
              L + E    R +E  +         +RQ   ER+R +   +E ++ ++E++R + + +
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEEQQLRRQ---ERERKF-LQEEQQLRRQELERKFREEE 1729

Query: 287  EKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPL 346
            +  +E + + +      +    +E+    R+    +    D   +  + +   + E+   
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR 1789

Query: 347  TPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVE 406
            + E+    + K+ E   L  + + Q+         L P  +R+ K+  +EE   ++++ +
Sbjct: 1790 SQES----DRKFREEEQLRQEREEQQ---------LRP-QQRDGKYRWEEEQLQLEEQEQ 1835

Query: 407  KLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREM 466
            +L  E +R+   ++Q        REE+  W                    +EEE+ +R+ 
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELW--------------------QEEEQKRRQE 1875

Query: 467  LLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRFS 512
               KL E     Q     ++  +  +   E K H     P T++F+
Sbjct: 1876 RERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFA 1921



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 57/261 (21%), Positives = 116/261 (44%), Gaps = 46/261 (17%)

Query: 223 KKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLY 282
           K+ +  + + ++ +RR +   + LE      +RQ   E++R     +E    Q E Q   
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE----QSEKQ--- 158

Query: 283 HKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPE 342
            +L++++R+   + ++  R         +E   R+    + +    C KG +T E+F P+
Sbjct: 159 ERLEQRDRQRRDEELWRQR---------QEWQEREERRAEEEQLQSC-KGHET-EEF-PD 206

Query: 343 EYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVK 402
           E  L    ++    K  E      + Q Q+++R           E EEK     E  + K
Sbjct: 207 EEQLRRRELLELRRKGRE------EKQQQRRERQDRV-----FQEEEEKEWRKRETVLRK 255

Query: 403 QEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERL 462
           +E +  E+E +R+   ++++E+   LER+E               ++   + + ++++RL
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLRKLERQE---------------LRRERQEEEQQQQRL 300

Query: 463 KREMLLAKLNEID-RELQDSR 482
           +RE  L +  E + RE Q+ R
Sbjct: 301 RREQQLRRKQEEERREQQEER 321


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 102/441 (23%), Positives = 193/441 (43%), Gaps = 50/441 (11%)

Query: 82   GFRSQSLNRE--PLRKDTDLVTKRILSARLL--KINELQNEVSELQVKLAELLKENKSLK 137
            G R++ L  E   L K+ +L+ K+I + ++   KI  L+ E SEL+ +  +L K   S K
Sbjct: 624  GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683

Query: 138  RLQYRQEKALNKFEDAENEISQLIFRHNNE---ITALKERLRKSQEKERATEKRVKDTES 194
             L ++ E +L K E+++ +   L  R N E     ++K    + + KE  +EK       
Sbjct: 684  NLTFQLE-SLEK-ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741

Query: 195  ELFRTKFSLQKLKEIS------EARHLPER-DDLAKKLVSAELKLDDTERRIKELSKNLE 247
            EL +  F   +  E+S      E + L +  ++  KK+   E +L D E   + L KNLE
Sbjct: 742  ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801

Query: 248  -LSTNSFQRQLLAERKRAYEAHD-----ENKVLQKEVQRLYHKLKEKERELDIKNIYSNR 301
             L  +S + + L +  ++ E        + K L+KE +RL  + + K+  L+  N+    
Sbjct: 802  ELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861

Query: 302  LPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEP 361
            L K +    KE+ + K +  +    +   K +        +      E ++  + K ++ 
Sbjct: 862  LEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQM 921

Query: 362  GH----LTLDLQ----SQKQDRHGEAGILN--PIMEREEKFVTDEELHVVKQEVEKLEDE 411
             +    LT +L+    ++++  H E    +   ++E + +    + L + ++++  LE  
Sbjct: 922  NNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEAR 981

Query: 412  WE---------REELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERL 462
             E         R+EL   +K   +L +R+++      R      PI   D     E +  
Sbjct: 982  LEESTNYNQQLRQELKTVKKNYEALKQRQDEE-----RMVQSSPPISGEDNKWERESQET 1036

Query: 463  KREMLLAKLNEIDRELQDSRN 483
             RE+L  K    DR ++  RN
Sbjct: 1037 TRELLKVK----DRLIEVERN 1053



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 97/412 (23%), Positives = 181/412 (43%), Gaps = 69/412 (16%)

Query: 85  SQSLNREPLRKDTDLVTKRILSARLLKINELQNE-----VSEL--------QVKLAELLK 131
           S+ L +E  + +  + T R  S R +KI E +NE     VS L        + ++ ++ K
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587

Query: 132 ENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKD 191
           ENK L          L+K E  + +I +       E+   KE+  +++E E   E    +
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKK-------ELEHYKEKGERAEELE--NELHHLE 638

Query: 192 TESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTN 251
            E+EL + K +  K+                +K+ + E +  + ER  ++L K L+ S  
Sbjct: 639 KENELLQKKITNLKI--------------TCEKIEALEQENSELERENRKLKKTLD-SFK 683

Query: 252 SFQRQLLAERKRAYEAHDENKVLQKEVQRL-YHKLKEKERELDIKNIYSNRLPKSSPNKE 310
           +   QL +  K   +  +EN  L++ V+ L    +K  + +L+ K + S +        +
Sbjct: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK-----EQLK 738

Query: 311 KELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQS 370
           K L L K +  +++  ++  +G+    D + +    T E      NK  +       L+S
Sbjct: 739 KGLELLKASFKKTERLEVSYQGL----DIENQRLQKTLEN----SNKKIQ------QLES 784

Query: 371 QKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLER 430
           + QD   E   L   +  EE  ++ + L  +++E + LE E  + E DKKQ EK +   R
Sbjct: 785 ELQDLEMENQTLQKNL--EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842

Query: 431 EEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAK-----LNEIDRE 477
           ++  E +    +     I N++K    E + L +E+ + K     L E+++E
Sbjct: 843 QQ-AEIKDTTLEENNVKIGNLEK----ENKTLSKEIGIYKESCVRLKELEKE 889



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 105/462 (22%), Positives = 203/462 (43%), Gaps = 87/462 (18%)

Query: 91  EPLRKDTDLV--TKRILS-------ARLLKINELQNEVSELQVKL--------------A 127
           E L++D  ++  TK +L        AR  K++EL+ E  +L+ KL               
Sbjct: 347 EELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE 406

Query: 128 ELLKENKSLKRLQYR-QEKALNKFEDAE--------NEISQLIFRHN-NEITALK----- 172
           EL++EN +L+  Q +  +++L+   + E        +E  Q    H  NE+T+ +     
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466

Query: 173 ---ERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE---------ISEARHLPERDD 220
              + L K+ E+ R T   V+   S++ + +   Q+L +         + E + L    +
Sbjct: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526

Query: 221 LAKKLVSAELKLDDT--------ERRIKEL---SKNLELSTNSF-QRQLLAERKRAYEAH 268
           L+K L+  + +L+ T        ER+IK L   +++L  + +S  QR  ++   R  +  
Sbjct: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586

Query: 269 DENKVLQKEVQRLYHKLKEKERE-LDIKNIYSNRLPKSSPNKEKELAL----RKNAACQS 323
            ENK+L + ++    KL + E E   IK    +   K    +E E  L    ++N   Q 
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQK 646

Query: 324 DFADL---CTKGVQTMEDFKPE---EYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHG 377
              +L   C K ++ +E    E   E     +T+  ++N       LT  L+S +++ + 
Sbjct: 647 KITNLKITCEK-IEALEQENSELERENRKLKKTLDSFKN-------LTFQLESLEKE-NS 697

Query: 378 EAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWE 437
           +    N  + R  + +    + + + ++E  E E E+E+L K  +   +  ++ E+ E  
Sbjct: 698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757

Query: 438 TGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQ 479
              YQ G+  I+N    +  E    K + L ++L +++ E Q
Sbjct: 758 ---YQ-GL-DIENQRLQKTLENSNKKIQQLESELQDLEMENQ 794



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 87/383 (22%), Positives = 161/383 (42%), Gaps = 53/383 (13%)

Query: 85   SQSLNREPLRKDTDLVTKRILSARLLKINELQNE-VSELQVKLAELLKENKSLKRLQYRQ 143
            ++SL +E  + + D       + RL +  E+++  + E  VK+  L KENK+L +     
Sbjct: 817  NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876

Query: 144  EKALNKFEDAENEISQLIFRHNNEI---TALKERLRKSQEKERATEKRVKDTESELFRTK 200
            +++  + ++ E E  +L+ R   +I     L+E L   + K +     ++    EL   K
Sbjct: 877  KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL--EK 934

Query: 201  FSLQKLKEISEARHLPERDDLAKKLVSAELK--LDDTERRIKELSKNLELSTNSFQ--RQ 256
              L K + + + +   +R  L +  + + LK  L+  E +I  L   LE STN  Q  RQ
Sbjct: 935  IGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 994

Query: 257  LLAERKRAYEA----HDENKVLQ----------------KEVQRLYHKLKEKERELDIKN 296
             L   K+ YEA     DE +++Q                +E  R   K+K++  E++  N
Sbjct: 995  ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1054

Query: 297  IYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYEN 356
                   ++   + K+L  + N   Q+    L  + V   E            T +  +N
Sbjct: 1055 ATLQAEKQALKTQLKQLETQNN-NLQAQILALQRQTVSLQEQ----------NTTLQTQN 1103

Query: 357  KWEEPGHLTLDLQSQK-QDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWERE 415
               +  + TL+ QS    +++ +  I    +E E + V  E     +++++ L D     
Sbjct: 1104 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE-----REDLKSLYDSL--- 1155

Query: 416  ELDKKQKEKASLLEREEKPEWET 438
                K  EK  LL   +  E+E+
Sbjct: 1156 ---IKDHEKLELLHERQASEYES 1175



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 50/231 (21%), Positives = 97/231 (41%), Gaps = 37/231 (16%)

Query: 105  LSARLLKINE----LQNEVSELQVKLAELLKENKSLKR----LQYRQEKALNKFEDAENE 156
            L A++L +      LQ + + LQ + A+L  EN +L      L  +  + L +    ENE
Sbjct: 1078 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1137

Query: 157  ISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLP 216
             ++ + +   ++ +L + L K  EK     +R       L     +L+   +  E  H  
Sbjct: 1138 -NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR- 1195

Query: 217  ERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQ------RQLLAERKRAYEAHD- 269
            + +D   +L+  + +L+D E+ +K   + + L   + +      ++L  E  R    +  
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255

Query: 270  ---ENKVLQKEVQRL-----------------YHKLKEKERELDIKNIYSN 300
               E +VLQ + + L                 + KLKE+ ++LDI +   N
Sbjct: 1256 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1306


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 83/417 (19%), Positives = 191/417 (45%), Gaps = 35/417 (8%)

Query: 99  LVTKRILSARLLKINELQ----NEVSELQVKLAELLKENKSLK-RLQ--YRQEKALNKFE 151
           LV+K+ L  RL+++ E +    N+   LQ+++ ++L++N++LK ++Q  + Q  A     
Sbjct: 540 LVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSAS 599

Query: 152 DAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISE 211
               E+ ++I   + +I   ++ L   +++  + E+ +KD ++  F  K  +QKL+    
Sbjct: 600 VLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA--- 656

Query: 212 ARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDEN 271
                    LA +  +A  +L+  ++ +      + L     Q ++  + +     +D+N
Sbjct: 657 ---------LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707

Query: 272 KVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTK 331
           K L+ EVQ+L   + E+  +  ++     ++ K    K+++L   +    ++    + TK
Sbjct: 708 KALKSEVQKLQTLVSEQPNKDVVE-----QMEKCIQEKDEKLKTVEE-LLETGLIQVATK 761

Query: 332 GVQTMEDFKPEEYPLTPET--IMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMERE 389
             + +   + E   LT E   +   +N       L  +L+    ++ G+   +  ++E E
Sbjct: 762 -EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAE 820

Query: 390 EKFVTDEELHV---VKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMY 446
              V ++E  V   +  +V++L++  + +E  ++     ++LE +EK    TG++   + 
Sbjct: 821 LLKVANKEKTVQLSITSKVQELQNLLKGKE--EQMNTMKAVLEEKEKDLANTGKWLQDLQ 878

Query: 447 PIQNMDKLQGEE--EERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHS 501
                 K   +E  +  LK     ++  E++  L++  N    +  +L + ES L S
Sbjct: 879 EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSS 935



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 84/428 (19%), Positives = 186/428 (43%), Gaps = 48/428 (11%)

Query: 110 LKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEIT 169
           +++ E +    E+Q  + +   E+++       Q+   +KF   ENE+  L  +  + + 
Sbjct: 488 VQLQEAERRWEEVQSYIRKRTAEHEAA------QQDLQSKFVAKENEVQSLHSKLTDTLV 541

Query: 170 A---LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEA--RHLPERDDLAKK 224
           +   L++RL +  E E   +KRV   ES     +  +Q + E +EA    + +       
Sbjct: 542 SKQQLEQRLMQLMESE---QKRVNKEES----LQMQVQDILEQNEALKAQIQQFHSQIAA 594

Query: 225 LVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHK 284
             SA +  ++  + I E  K ++ + +S    L +ER R     +E     K++Q +   
Sbjct: 595 QTSASVLAEELHKVIAEKDKQIKQTEDS----LASERDRLTSKEEE----LKDIQNMNFL 646

Query: 285 LKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEY 344
           LK + ++L      +N    ++   EK   ++++   + D   L  + +Q     K EE+
Sbjct: 647 LKAEVQKL---QALANEQAAAAHELEK---MQQSVYVKDDKIRLLEEQLQHEISNKMEEF 700

Query: 345 PLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQE 404
            +  +     +++ ++       L S++ ++     +   I E++EK  T EEL     E
Sbjct: 701 KILNDQNKALKSEVQK----LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEEL----LE 752

Query: 405 VEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLK- 463
              ++   + EEL+  + E +SL +  +  + +          ++ + K+  E++ ++K 
Sbjct: 753 TGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 812

Query: 464 -REMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYR--FSESSERLFN 520
             E+L A+L ++  +    + ++  +   + + ++ L   E    T +    E  + L N
Sbjct: 813 VEELLEAELLKVANK---EKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLAN 869

Query: 521 -GHHLQDI 527
            G  LQD+
Sbjct: 870 TGKWLQDL 877



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 45/213 (21%), Positives = 98/213 (46%), Gaps = 21/213 (9%)

Query: 79  VRVGFRSQSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKR 138
           ++V  + + LN   +R +   +TK +       +   QN+    QV  A L++E K +  
Sbjct: 756 IQVATKEEELNA--IRTENSSLTKEVQD-----LKAKQND----QVSFASLVEELKKVIH 804

Query: 139 LQYRQEKALNKFEDAE-----NEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTE 193
            +  + K++ +  +AE     N+   +     +++  L+  L+  +E+    +  +++ E
Sbjct: 805 EKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKE 864

Query: 194 SELFRTKFSLQKLKEISEA--RHLPERDDLAKKLVSAELKLDDTERRIKELS---KNLEL 248
            +L  T   LQ L+E +E+   H+ E      K  S+  + ++ E  +KE     K LE 
Sbjct: 865 KDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEA 924

Query: 249 STNSFQRQLLAERKRAYEAHDENKVLQKEVQRL 281
                +  L ++ +   +  DENK+ + ++++L
Sbjct: 925 MLKERESDLSSKTQLLQDVQDENKLFKSQIEQL 957



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 81/382 (21%), Positives = 144/382 (37%), Gaps = 77/382 (20%)

Query: 103  RILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKAL----NKFEDAENEIS 158
            +++S R  +I+ L NE+  L+  +    K+N  L+   +   +AL       +D  N+ S
Sbjct: 976  KVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTS 1035

Query: 159  QLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPE- 217
                         KER    Q++  A E   K+   +LF  K S+       E  H  E 
Sbjct: 1036 -------------KER----QQQVEAVELEAKEVLKKLF-PKVSVPSNLSYGEWLHGFEK 1077

Query: 218  --RDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQ 275
              ++ +A    S E+K+   E ++KE  +   L       QL  E+ ++  A  E  +LQ
Sbjct: 1078 KAKECMAGTSGSEEVKV--LEHKLKEADEMHTL------LQLECEKYKSVLAETEG-ILQ 1128

Query: 276  KEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQT 335
            K    L   ++++E +  +K   S++  K                 QS F    T   Q 
Sbjct: 1129 K----LQRSVEQEENKWKVKVDESHKTIKQ---------------MQSSF----TSSEQE 1165

Query: 336  MEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPI---------- 385
            +E  + E   +        EN   E  HL ++L+  + +R      +  +          
Sbjct: 1166 LERLRSENKDI--------ENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTK 1217

Query: 386  --MEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQL 443
               E+ E+     +LH  +Q +E ++ +  +   D    E + +    E  E ET    L
Sbjct: 1218 LRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSL 1277

Query: 444  GMYPIQNMDKLQGEEEERLKRE 465
                 Q    LQ   ++  K +
Sbjct: 1278 NQTVTQLQQLLQAVNQQLTKEK 1299


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 91/418 (21%), Positives = 182/418 (43%), Gaps = 57/418 (13%)

Query: 114  ELQNEVSELQVKLAELLKENKSL--------KRLQYRQEKALNKFEDAENEISQL----- 160
            EL ++V +L  K+  L KE  S          +    ++KA ++F   +N + +L     
Sbjct: 1409 ELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLE 1468

Query: 161  -----IFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHL 215
                  +  + +I  LKE L +  ++    +  ++D +S++ + + +L+   +   AR +
Sbjct: 1469 LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIM 1528

Query: 216  PERDDLAKKLVSAE-----LKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDE 270
               D + +K +  E     LK  + ++ I+   K L      FQ     +  R  EA ++
Sbjct: 1529 ELEDHITQKTIEIESLNEVLKNYNQQKDIEH--KELVQKLQHFQELGEEKDNRVKEAEEK 1586

Query: 271  NKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCT 330
               L+ +V  +  +L+ K++EL+    + N   KS   + K L  R  +   +  A+L  
Sbjct: 1587 ILTLENQVYSMKAELETKKKELE----HVNLSVKSKEEELKALEDRLESESAAKLAELKR 1642

Query: 331  KGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREE 390
            K  Q +   K +      E    Y+   E   HL+ +L ++ Q+R  E  IL   ++  E
Sbjct: 1643 KAEQKIAAIKKQLLSQMEEKEEQYKKGTE--SHLS-ELNTKLQEREREVHILEEKLKSVE 1699

Query: 391  KFVTDEELHVVKQEVEKLEDEWEREELD------KKQKEKASLLER-------------E 431
               +  E  +V +  + +    E+EE D      K  +EK S+L+R             +
Sbjct: 1700 S--SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQ 1757

Query: 432  EKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVL 489
            EK E  +  +++     + + KL+  E ++ + + ++  L E   EL++ +N KY ++
Sbjct: 1758 EKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE---ELEE-KNKKYSLI 1811



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 109/459 (23%), Positives = 190/459 (41%), Gaps = 69/459 (15%)

Query: 95  KDTDLVTKRILSARLLKINELQNE-------VSELQVKLAELLKENKS-LKRLQYRQEKA 146
           ++ +L  K IL+    K+ +LQ E       + EL+  L + L+ENK+  K L    E  
Sbjct: 538 EELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAE 597

Query: 147 LNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKF----- 201
            NK      EI+ ++ +H  E+ +LK +      ++    K+   TE E  R K      
Sbjct: 598 KNKH---NKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKE 654

Query: 202 SLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNL--------ELS---- 249
           +L K KEI    H+ E ++  K L   ++K  + E    ELS+ L        ELS    
Sbjct: 655 TLLKDKEIIFQAHIEEMNE--KTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712

Query: 250 -TNSFQRQLLAERKRAYEAHDE----------------NKVLQKEVQRLYHKLKEKEREL 292
            T+  +++L A+       H +                 K L+ ++ +L   LKE+++ L
Sbjct: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHL 772

Query: 293 DIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIM 352
                +   L       E EL   + A+ + D                 E+     + ++
Sbjct: 773 KEHQAHVENLEADIKRSEGEL---QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829

Query: 353 CYENKWEEPGHLTLDLQSQKQDRHGEAGI----LNPIMEREEKFVTDEELHV--VKQEVE 406
             E +         ++++QK+D   E       +  +M++ EK  ++ E  V  + Q  E
Sbjct: 830 DLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYE 889

Query: 407 -KLEDEWEREELDKK---QKEKASLLERE-EKPEWETGRYQLGMYPIQNMDKLQGEEEER 461
            KLED  + +E  K+   +KE   L  RE +K E E    +L      ++  L  E E +
Sbjct: 890 SKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKE-DSIHILNEEYETK 948

Query: 462 LK-REMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKL 499
            K +E  + K+ +  +E+Q++   K      L D E+KL
Sbjct: 949 FKNQEKKMEKVKQKAKEMQETLKKK------LLDQEAKL 981



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 74/354 (20%), Positives = 154/354 (43%), Gaps = 37/354 (10%)

Query: 90  REPLRKDTDLV----TKRILSARLLKINELQNEVSELQVKLAELLKENKSLKR-LQYRQE 144
           +E L KD +++     + +    L K++  Q E+  L  +L+E+LK    L+  L   ++
Sbjct: 653 KETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKD 712

Query: 145 KALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQ 204
           +     ++ E ++ +    H  ++ ++   +++ +   + TEK +KD  ++L        
Sbjct: 713 QTDKMKQELEAKMDEQKNHHQQQVDSI---IKEHEVSIQRTEKALKDQINQLELL----- 764

Query: 205 KLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLEL----------STNSFQ 254
            LKE    +HL E     + L   E  +  +E  +++ S  L++           T +++
Sbjct: 765 -LKE--RDKHLKEHQAHVENL---EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYE 818

Query: 255 RQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELA 314
            QL   +++  +   E  +L K+V  +  + K+   ELD   I    L +    +  E+ 
Sbjct: 819 EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME 878

Query: 315 LRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQD 374
            +  +  Q  +      G +  E  K          +   E + +E   LT  L +++  
Sbjct: 879 QKVKSLTQV-YESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS 937

Query: 375 RHGEAGILNPIMEREEKFVTDE-ELHVVKQEVEKLEDEWEREELDKKQKEKASL 427
            H    ILN   E E KF   E ++  VKQ+ +++++  +++ LD++ K K  L
Sbjct: 938 IH----ILNE--EYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKEL 985



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 113/524 (21%), Positives = 201/524 (38%), Gaps = 87/524 (16%)

Query: 31  QSSGRSSLVSSSPASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNR 90
           +SS + SLV +S     R++  R   D       P    P  + +     VG  S SLN+
Sbjct: 86  RSSSKESLVRTSS----RESLNRLDLDSSTASFDP----PSDMDSEAEDLVG-NSDSLNK 136

Query: 91  EPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKR-LQYRQEKALNK 149
           E L +    + + + S R         + SEL      L +E K L+  L   Q+K+L +
Sbjct: 137 EQLIQRLRRMERSLSSYR--------GKYSELVTAYQMLQREKKKLQGILSQSQDKSLRR 188

Query: 150 FEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLK-- 207
             +   E+             + ++ +K  ++E       KD    + +T+ SL K +  
Sbjct: 189 IAELREELQ------------MDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR 236

Query: 208 ----EISEARHLPERDDLAKKLVSAELKLDDTERRIKELS--KNLELSTNSFQRQ--LLA 259
                +   + LP+ +  A+     E    D E  +++ +  K LE      +RQ  LL 
Sbjct: 237 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLK 296

Query: 260 ERKRAYEAHDEN-KVLQKEVQRLYHKLKEKERELD-IKNIY--------------SNRLP 303
             K   ++H E   +L  E + L  +L E+ +EL+ IK+++               N + 
Sbjct: 297 RCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIE 356

Query: 304 KSSPNKEKELALRKN-------------AACQSDFADLCTKGVQTMEDFKPEEYPLTPET 350
           +   +K   +A  K              A  +S    + T+G +  E  +  E     E 
Sbjct: 357 QLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL 416

Query: 351 IMCYENKWE-EPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLE 409
                   + E     L  +  +Q +  E          EE+    +EL  VKQEV  + 
Sbjct: 417 EKALSTAQKTEEARRKLKAEMDEQIKTIEK------TSEEERISLQQELSRVKQEVVDVM 470

Query: 410 DEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLA 469
            +   E++ K QK     L R+E+   +  + +   +  Q    L+  + E LK      
Sbjct: 471 KKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQ--- 527

Query: 470 KLNEIDRELQDS---RNLKYPVLPLLPDFESKLHSPERSPKTYR 510
                ++E Q+S     L+     +L + E+KL   ++  +TYR
Sbjct: 528 -----EKEQQESLALEELELQKKAILTESENKLRDLQQEAETYR 566



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 101/445 (22%), Positives = 187/445 (42%), Gaps = 74/445 (16%)

Query: 111  KINELQNEV----SELQVKLAELLKENKSLKRLQYRQEKALNKFEDAEN--EISQLIFRH 164
            KI  L+N+V    +EL+ K  EL   N S+K  +  + KAL    ++E+  ++++L  + 
Sbjct: 1586 KILTLENQVYSMKAELETKKKELEHVNLSVKSKE-EELKALEDRLESESAAKLAELKRKA 1644

Query: 165  NNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKK 224
              +I A+K++L    E++   E+  K TES L        KL+E     H+     L +K
Sbjct: 1645 EQKIAAIKKQLLSQMEEKE--EQYKKGTESHLSELN---TKLQEREREVHI-----LEEK 1694

Query: 225  LVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHK 284
            L S E    +T   +   +KN+   T         E++ A       K  ++++  L   
Sbjct: 1695 LKSVESSQSET-LIVPRSAKNVAAYT---------EQEEADSQGCVQKTYEEKISVLQRN 1744

Query: 285  LKEKEREL-----DIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDF 339
            L EKE+ L     + +   S+        +E+ + L    A Q +   +     + +E+ 
Sbjct: 1745 LTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE- 1803

Query: 340  KPEEYPLTPETIMCYENKWEEPGHLTL-----------DLQSQKQDRHGEAGIL-NPIME 387
            K ++Y     +++  ++  +E G   +           D+Q   Q++     IL   I E
Sbjct: 1804 KNKKY-----SLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKE 1858

Query: 388  REEKFVTDEELHVVKQEVEKLEDEWER----EELDKKQKEKASLLEREEKPEWETGRYQL 443
             +   V  +E+H V  E+E+L  ++E+    +++D + K    L   EE  E ++  + +
Sbjct: 1859 LDSCLVRQKEVHRV--EMEELTSKYEKLQALQQMDGRNKPTELL---EENTEEKSKSHLV 1913

Query: 444  GMYPIQNMD--------KLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDF 495
                + NM+        KL G E E+ K    + +L +  R L+     +  +L      
Sbjct: 1914 QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL------ 1967

Query: 496  ESKLHSPERSPKTYRFSESSERLFN 520
              K +  ER  K  +  E  E   N
Sbjct: 1968 -KKEYDQEREEKIKQEQEDLELKHN 1991



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 99/525 (18%), Positives = 200/525 (38%), Gaps = 62/525 (11%)

Query: 116  QNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERL 175
            + ++++LQ KL +L  E   L        K + + E  + ++   +  H  ++  L ++L
Sbjct: 818  EEQLAQLQQKLLDLETERILLT-------KQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870

Query: 176  RK-SQEKERATEKRVKDTESELFRTKFSLQKLKEI---SEARHLPERDDLAKKLVSAELK 231
             K + E E+  +   +  ES+L       ++ K+I    E   L  R+   K++     K
Sbjct: 871  EKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQK 930

Query: 232  LDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAH--------DENKVLQKEVQRLYH 283
            L   E  I  L++  E    + ++++   +++A E          D+   L+KE++    
Sbjct: 931  LSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTAL 990

Query: 284  KLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEE 343
            +L +KE++ + K +              E+A   +A      + L T   + +E      
Sbjct: 991  ELSQKEKQFNAKML--------------EMAQANSAGISDAVSRLETNQKEQIESLTEVH 1036

Query: 344  YPLTPETIMCYENKWEEPGHLTLDL-QSQKQDRHGEAGILNP--IMEREEKFVTDEELHV 400
                 + I  +E K  +      ++ + Q Q++  E   L    ++   EK   ++E+  
Sbjct: 1037 RRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITW 1096

Query: 401  VKQEVEKLEDEWE--REELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGE- 457
            +K+E  K +      +E+L +K     SL + E K +    + ++ +      +    E 
Sbjct: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156

Query: 458  --------EEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPD--FESKLHSPERSPK 507
                    EE++ K   L +KL   D E Q  ++        L D   E K  S E + +
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQ 1216

Query: 508  TYRFSESSERLFNGHHLQDISFSTPKGEG---------QNSGNVRSPASPNEFAFGSYVP 558
                 + +E L      + I+ S+ K              +  V+               
Sbjct: 1217 LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEA 1276

Query: 559  SFAKTSERSN----PFSQKSSFLDFQRNSMEKLSKDGVDLITRKE 599
               + +E  N     F Q +  L+ + N ++ +  D   L+T KE
Sbjct: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKE 1321



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 88/448 (19%), Positives = 185/448 (41%), Gaps = 39/448 (8%)

Query: 88   LNREPLRKDTDL-VTKRILSARLLKINELQNEVSELQVKLAELLKE-NKSLKRLQYRQEK 145
            L  E +++DT L   +  L  +   +N L  + ++L+  L +L  + NKSLK   + QE+
Sbjct: 1097 LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156

Query: 146  ALNK---FEDAENEISQLIFR---HNNEITALKERLRKSQEKERATEKRVKDTESEL-FR 198
             +      E+ + ++S+L  +    + E  +LK    KS +         K    EL  +
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQ 1216

Query: 199  TKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLL 258
                 +K + + EA+     +  + K  +   ++   + R  ++ + L + T +   +L 
Sbjct: 1217 LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS-ELE 1275

Query: 259  AERKRAYEAHDENKVLQKEVQRLYHKLKEKEREL-----DIKNIYSNRLPKSSPNKEKEL 313
            A+ ++  E   E   L    Q+  H+L+EKE ++     DI+++ + +         ++ 
Sbjct: 1276 AQLRQLTE---EQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQ 1332

Query: 314  ALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQ 373
            A  +  +C +      ++ +  +   K E      E  +   +  ++   L + LQ+   
Sbjct: 1333 AASEKESCITQLKKELSENINAVTLMKEE----LKEKKVEISSLSKQLTDLNVQLQNSIS 1388

Query: 374  DRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEK 433
                EA I +   +       DEE   +  +V+ L       ++D   KEK S LE+ + 
Sbjct: 1389 LSEKEAAISSLRKQ------YDEEKCELLDQVQDLS-----FKVDTLSKEKISALEQVDD 1437

Query: 434  -----PEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPV 488
                  EW+             + +LQ + E + K      +   + +E  D +N ++  
Sbjct: 1438 WSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC 1497

Query: 489  LP-LLPDFESKLHSPERSPKTYRFSESS 515
            L   + D +SK+   E + +T   S+++
Sbjct: 1498 LKGEMEDDKSKMEKKESNLETELKSQTA 1525



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 63/316 (19%), Positives = 138/316 (43%), Gaps = 25/316 (7%)

Query: 108  RLLKINELQNEVSELQVK-LAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNN 166
            + L+  EL  ++ E ++K L   L   K + R++   E+  +K+E  +    Q +   N 
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVE--MEELTSKYEKLQ--ALQQMDGRNK 1895

Query: 167  EITALKERLRKSQEKERATEKRVKDTESELFRTKFSL-----QKLKEISEARHLPERDDL 221
                L+E   +  +      K + + E++    +F L     +K K   E   L +   +
Sbjct: 1896 PTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRM 1955

Query: 222  AKKLVSAELKL------DDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQ 275
             +K    EL++       + E +IK+  ++LEL  NS  +QL+ E     +   + + L+
Sbjct: 1956 LRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNT--QLAQKEQELE 2013

Query: 276  KEVQRLYHKLKEKERE-LDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQ 334
              ++   +K +E E E L+     +N+L K    K+ +  L++ A    +  D   + + 
Sbjct: 2014 MTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDD--LKRTAKRYEEILDAREEEMT 2071

Query: 335  T-MEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFV 393
              + D + +   L  +     E + E PG+  + +   +     +  +++    +E++F 
Sbjct: 2072 AKVRDLQTQLEELQKKYQQKLEQE-ENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEF- 2129

Query: 394  TDEELHVVKQEVEKLE 409
              E++H ++  ++K E
Sbjct: 2130 -REQIHNLEDRLKKYE 2144



 Score = 34.3 bits (77), Expect = 0.40
 Identities = 88/378 (23%), Positives = 145/378 (38%), Gaps = 73/378 (19%)

Query: 116  QNEVSELQVKLAELLKENKSLKRL-QYRQEKALNKFEDAENEISQLIFRHNNEITALKER 174
            + ++S LQ  L E   + K L+R+ Q ++E   + FE       +LI   + E    +++
Sbjct: 1735 EEKISVLQRNLTE---KEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQ 1791

Query: 175  LRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPER--DDLAKKLVSAELKL 232
                  +E   EK  K   S +       +  K   +A+   E   DD+ K L   EL  
Sbjct: 1792 SMIGHLQEELEEKNKK--YSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTC 1849

Query: 233  DDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKEREL 292
               E++IKEL   L                R  E H   +V  +E+   Y KL+  + ++
Sbjct: 1850 QILEQKIKELDSCL---------------VRQKEVH---RVEMEELTSKYEKLQALQ-QM 1890

Query: 293  DIKNIYSNRLPKSSPNKEK----ELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTP 348
            D +N  +  L +++  K K    +  L  N   Q +  +    G +       E+  L  
Sbjct: 1891 DGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAER------EKQKLGK 1944

Query: 349  ETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNP--IMEREEKFVTDEELHVVKQEVE 406
            E +            L  DL+  +++   E  IL      EREEK         +KQ   
Sbjct: 1945 EIV-----------RLQKDLRMLRKEHQQELEILKKEYDQEREEK---------IKQ--- 1981

Query: 407  KLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERL---- 462
                  E+E+L+ K       L RE   +      +L M   + ++K Q  E E L    
Sbjct: 1982 ------EQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQ 2035

Query: 463  -KREMLLAKLNEIDRELQ 479
             +   LL K+ E D +L+
Sbjct: 2036 EETNQLLKKIAEKDDDLK 2053


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 74/355 (20%), Positives = 163/355 (45%), Gaps = 28/355 (7%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           KI E + ++ E + K+ E  ++ +  +    RQE+ + + E+      ++++    ++  
Sbjct: 369 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 428

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAEL 230
            +E + + +EK R  E+++ + E    + +   +K +E  + R   +R +   K+   E 
Sbjct: 429 QEEMMWEKEEKIRELEEKMHEQE----KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 484

Query: 231 KLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKER 290
           K+ + E +I+E  + +       Q + + E+++  E  +E +  Q+E+ R   K++E+E 
Sbjct: 485 KIREQEEKIREQEEKMWR-----QEEKIHEQEKIRE--EEKRQEQEEMWRQEEKIREQEE 537

Query: 291 ELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPET 350
               K     +  K    +EK     +    Q +      + V   E+   E+     E 
Sbjct: 538 IWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQ----EEK 593

Query: 351 IMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLED 410
           I   E K  E   +T     +++++ GE      + E+EEK    EE  + +QE +  E 
Sbjct: 594 IREQEEKIREQEEMT----QEQEEKMGEQE--EKMCEQEEKMQEQEE-KMRRQEEKIREQ 646

Query: 411 EWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKRE 465
           E +  E ++K +E+  +++ +E+  WE           +  +K+Q E+EE+++R+
Sbjct: 647 EKKIREQEEKIREQEEMMQEQEEKMWEQEEKM-----CEQEEKMQ-EQEEKMRRQ 695



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 85/446 (19%), Positives = 197/446 (44%), Gaps = 49/446 (10%)

Query: 35  RSSLVSSSPASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLR 94
           R S ++ +   +   +P+   S G       +K    G         G  S    ++   
Sbjct: 117 RQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQKASH 176

Query: 95  KDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAE 154
           +  + + +R L A++  I  L  + +ELQ+ L        ++K+L+      +++  D+ 
Sbjct: 177 QHQEAL-RRELEAQVHTIRILTCQKTELQMAL---YYSQHAVKQLEGEARDLISRLHDSW 232

Query: 155 NEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTES---ELFRTKFSLQKLKEISE 211
               +L       ++A+  + +K+   +R  E+  K+ ++   EL+R   + ++LKE   
Sbjct: 233 KFAGEL----EQALSAVATQKKKA---DRYIEELTKERDALSLELYRNTITDEELKE--- 282

Query: 212 ARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDEN 271
                +   L +KL   E +  + +  +KEL + LE +     + LL +++   EA    
Sbjct: 283 -----KNAKLQEKLQLVESEKSEIQLNVKELKRKLERA-----KLLLPQQQLQAEADH-- 330

Query: 272 KVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTK 331
             L KE+Q +  KL+ +  E ++ N  + +  +    +E+++   +    + +      K
Sbjct: 331 --LGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE-----EK 383

Query: 332 GVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEK 391
             +  E  + +E  +  +  M +E   EE      ++  +K+++          M R+E+
Sbjct: 384 IREQEEKIREQEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEK----------MRRQEE 431

Query: 392 FVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNM 451
            + ++E  + + E +  E E  RE+ +K+Q+E+  + E+E++ E E   ++      +  
Sbjct: 432 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE-KIREQEKRQEQEAKMWRQEEKIREQE 490

Query: 452 DKLQGEEEERLKREMLLAKLNEIDRE 477
           +K++ +EE+  ++E  + +  +I  E
Sbjct: 491 EKIREQEEKMWRQEEKIHEQEKIREE 516



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 28/150 (18%), Positives = 72/150 (48%), Gaps = 13/150 (8%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           KI E + +V   + K+ E  ++ +  +     QE+   + E+   E  + +     ++  
Sbjct: 572 KIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 631

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE---------ISEARHLPERDDL 221
            +E++R+ +EK R  EK++++ E ++   +  +Q+ +E           +   + E+++ 
Sbjct: 632 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 691

Query: 222 AK----KLVSAELKLDDTERRIKELSKNLE 247
            +    K+   E++L   E +++E  ++LE
Sbjct: 692 MRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 23/163 (14%), Positives = 78/163 (47%), Gaps = 10/163 (6%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           K+++ + ++ E + K+    ++ +  +     QE+ + + E+   E  + +     ++  
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE 624

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAEL 230
            +E++++ +EK R  E+++++ E ++   +  +++ +E+ + +         +K+   E 
Sbjct: 625 QEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE--------EKMWEQEE 676

Query: 231 KLDDTERRIKELSKNLELSTNSF--QRQLLAERKRAYEAHDEN 271
           K+ + E +++E  + +         Q   L +++   + H E+
Sbjct: 677 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEH 719



 Score = 33.5 bits (75), Expect = 0.68
 Identities = 28/171 (16%), Positives = 80/171 (46%), Gaps = 4/171 (2%)

Query: 46  VRRKNPKRQTSDGQVHHQAP--RKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKR 103
           +R++  K    + ++H Q    R+   K     + +R          E +R+  ++  ++
Sbjct: 552 IRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQ 611

Query: 104 I--LSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLI 161
              +  +  K+ E + ++ E + K+    ++ +  ++    QE+ + + E+   E  + +
Sbjct: 612 EEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 671

Query: 162 FRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEA 212
           +    ++   +E++++ +EK R  E+++ + E  L + +  +Q+ +E  EA
Sbjct: 672 WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 105/491 (21%), Positives = 202/491 (41%), Gaps = 76/491 (15%)

Query: 35  RSSLVSSSPASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLR 94
           R+S  SS+ A + +   +  T   Q+  Q       +       +++ F  + +    + 
Sbjct: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME 311

Query: 95  KDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAE 154
           +D     K++ ++   +I E +  + EL  K+ E  K+   LK      +K L       
Sbjct: 312 QD-----KKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG------ 360

Query: 155 NEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARH 214
            E+ + I + N EI  +K  L  S++KER + + +K    +L  T   LQK       + 
Sbjct: 361 -ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIK----QLMGTVEELQKRNH----KD 411

Query: 215 LPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDE---- 270
                D+ +++        +T+R++++L   L+        Q+  E  R + A  E    
Sbjct: 412 SQFETDIVQRME------QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKT 465

Query: 271 -NKVLQKEVQRLYHKLKEKERELDIKNIYSNRL---------PKSSPNKEKELALRKNAA 320
            +K   +   R Y  +   E ++ + N+  N L          K    +E  L L +  A
Sbjct: 466 RHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCA 525

Query: 321 CQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTL----DLQSQ----- 371
            Q    DL  +       F  E+     +TI   E+K  E  H +L    DL+++     
Sbjct: 526 LQRQLEDLVEE-----LSFSREQIQRARQTIAEQESKLNE-AHKSLSTVEDLKAEIVSAS 579

Query: 372 ----KQDRHGEAGILN-----PIMEREEKFVTDEELHVVKQEVEKLEDEW---EREELDK 419
               + +   EA + N      ++E+E+  V D      + E+E+L  +      EEL K
Sbjct: 580 ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK 639

Query: 420 KQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERL-----KREMLLAKLNEI 474
            +++    LE E +   E  +  LG++  Q +D LQ E  +++     +++ L+ K N++
Sbjct: 640 LKED----LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQL 695

Query: 475 DRELQDSRNLK 485
             E+   ++L+
Sbjct: 696 ILEISKLKDLQ 706



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 92/394 (23%), Positives = 173/394 (43%), Gaps = 70/394 (17%)

Query: 141  YRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQ------EKERATEKRVKDT-- 192
            Y  EK L  FE    E + +I R   E+     RL++ +      ++ER    R K+   
Sbjct: 1927 YADEKTL--FERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMK 1984

Query: 193  ------ESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELS--K 244
                  E +L +    L K K   + +    RDDL K++ + E+ +++   R  EL   K
Sbjct: 1985 AEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK 2044

Query: 245  NLEL-----STNSFQRQLLAERK----RAYEAHDENKVLQKEVQRLYHKLKEKERELDIK 295
            N EL        + ++QL   RK    +A +   E  V Q+E+Q+L  +LK   R   I 
Sbjct: 2045 NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104

Query: 296  NIYSNRLP------KSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYP---- 345
               +  +       K   +K  EL L K    Q D  +   + ++ +E F+  E      
Sbjct: 2105 EHQTREVEQLANHLKEKTDKCSELLLSKE-QLQRDIQER-NEEIEKLE-FRVRELEQALL 2161

Query: 346  LTPETIMCYENK-----WEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVT--DEEL 398
            ++ +T    E++      E    L+L++Q Q +            ++R+EK +T  +E+L
Sbjct: 2162 VSADTFQKVEDRKHFGAVEAKPELSLEVQLQAE---------RDAIDRKEKEITNLEEQL 2212

Query: 399  HVVKQEVEKLEDEWER--EELDKKQKEKASLLE--REEKPEWETGRYQLGMYPIQNMDKL 454
               ++E+E   +E ++   +L+ ++KE  + L+   +E   ++    +LG+  I+  D +
Sbjct: 2213 EQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGL-AIKESDAM 2271

Query: 455  QGEEEERL---------KREMLLAKLNEIDRELQ 479
              +++  L         ++E+ + +LNE   +LQ
Sbjct: 2272 STQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2305



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 86/403 (21%), Positives = 164/403 (40%), Gaps = 75/403 (18%)

Query: 119  VSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKS 178
            +SE+Q   A++     +LKR Q  ++ +    E    +    +     E++++K+R  + 
Sbjct: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150

Query: 179  QEKERATEKRVKDTESELFRTKFSLQ--------KLKEISEARHLPERD----------- 219
            QE+  + +  V + +SEL +TK  L+         LKE+ EA  L  +D           
Sbjct: 3151 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL-EAFRLEVKDKTDEVHLLNDT 3209

Query: 220  ---------DLAKKLVSAELKLDDTERRIKELSKNLELSTNS-----FQRQLLAERKRAY 265
                     +L   L   + KL  +E R KE  ++L+ S  S      Q  LL E+++  
Sbjct: 3210 LASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL 3269

Query: 266  EAHDENKVLQKEVQRLYHKL---KEKERELDIKNIYSN-----RLPKSSPNKEKELALRK 317
                + K+   E QR+ +     +E+ R L+++ +  +     R   S+ ++E+EL    
Sbjct: 3270 LNESQQKI---ESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL---- 3322

Query: 318  NAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHG 377
            +A  QS      ++     ED   E      E          E     LD    +Q    
Sbjct: 3323 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEK 3382

Query: 378  EAGILNPIMEREEKFVTD--EELHVVKQEVEKLEDEWERE-----ELDKKQKEKASLLER 430
            +  +    ++ E++  T+  +++H ++ +VE L+ + E +     +LD + +    +++ 
Sbjct: 3383 DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQE 3442

Query: 431  EEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNE 473
             +K E E                    EE+R  R +L   LNE
Sbjct: 3443 FQKQELE-------------------REEKRESRRILYQNLNE 3466



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 65/326 (19%), Positives = 130/326 (39%), Gaps = 29/326 (8%)

Query: 110  LKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEIT 169
            L+INELQ E+  L+ +  E     + ++ LQ + E    + ++ EN++ +   +   E +
Sbjct: 719  LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778

Query: 170  ALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEAR---HLPERDDLAKKLV 226
             LK+  +K+ E        V   E  +F      +    + E      + E +DL ++ +
Sbjct: 779  ILKDE-KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCI 837

Query: 227  SAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLK 286
                +++          KN E++    Q +     K   +  D     + E +    KLK
Sbjct: 838  QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK---SKLK 894

Query: 287  EKERELDIKNIYSNRLP-KSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYP 345
                EL ++ I    +  KSS   E +  + +            T+ ++ +E  K E+  
Sbjct: 895  ALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE 954

Query: 346  LTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIME--REEKFVTDEELHVVKQ 403
            L+                   DL  Q + +HGE   LN  ++  ++EK    E++ +  +
Sbjct: 955  LSQR---------------LSDLSEQLKQKHGEISFLNEEVKSLKQEK----EQVSLRCR 995

Query: 404  EVEKLEDEWEREELDKKQKEKASLLE 429
            E+E + +    E +     + +SLL+
Sbjct: 996  ELEIIINHNRAENVQSCDTQVSSLLD 1021



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 121/592 (20%), Positives = 244/592 (41%), Gaps = 106/592 (17%)

Query: 86  QSLNREPLRKDTDLVTKRILSARLLKINELQNEVSEL------QVKLAELLKENKSLKRL 139
           Q  N +  + +TD+V +R+      K+ +L+ E+ E+      Q+K   + +    ++ +
Sbjct: 405 QKRNHKDSQFETDIV-QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM 463

Query: 140 QYRQ----EKALNKFED-------------AENEISQLIFRHNNEITALKERLRKSQEKE 182
           + R     E AL  + +             A NE++  +   N++   LKE L    E++
Sbjct: 464 KTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEK 523

Query: 183 RATEKRVKDTESELFRTKFSLQKLKE--------ISEA-RHLPERDDLAKKLVSAELKLD 233
            A +++++D   EL  ++  +Q+ ++        ++EA + L   +DL  ++VSA     
Sbjct: 524 CALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSAS---- 579

Query: 234 DTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELD 293
              R+  EL    E++    + ++L + K        N VL +  +    +L+    +L 
Sbjct: 580 -ESRKELELKHEAEVTNYKIKLEMLEKEK--------NAVLDRMAESQEAELERLRTQL- 629

Query: 294 IKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTK----GVQTMEDFKPEEYPLTPE 349
              ++S+    S   ++ E+  R N     D   +  K    G+Q     K E      +
Sbjct: 630 ---LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD 686

Query: 350 TIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILN--------PIMEREEKFVTDEELHVV 401
            ++  +N+         DLQ    +   E   L          I+ +EEK     E   +
Sbjct: 687 NLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK-----EKGTL 741

Query: 402 KQEVEKLEDEWEREELDKKQKEKAS-LLEREEKPEWETGRYQLGMYPIQNMDKLQ---GE 457
           +QEV++L+   + E L+K+ KEK + L E+  + E E    +     +++M K+     +
Sbjct: 742 EQEVQELQ--LKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ 799

Query: 458 EEERLKREMLLAKL------NEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRF 511
           EE  +  + + +K        EI+  ++++ +LK   + L  +        E+   T+ F
Sbjct: 800 EERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-------EKQRNTFSF 852

Query: 512 SESSERLFNGHHLQ-----------DISFSTPKGEGQNSGNVRSPASPNEFAFGSYVPSF 560
           +E +  + N   LQ           D+  S  K E +    ++  A   E       P+ 
Sbjct: 853 AEKNFEV-NYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK--ALNEELHLQRINPTT 909

Query: 561 AKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITR----KEKKANLMEQL 608
            K   +S+ F +  +F+       E + KD  +L+ +    K +K  L ++L
Sbjct: 910 VKM--KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRL 959



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 71/358 (19%), Positives = 149/358 (41%), Gaps = 72/358 (20%)

Query: 116  QNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERL 175
            ++E    Q ++ +L ++ K + R Q   E    + E   N + +   + +  + + ++  
Sbjct: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQ 2136

Query: 176  RKSQEKERATEK---RVKDTESELFRTKFSLQKLK------------EIS-EARHLPERD 219
            R  QE+    EK   RV++ E  L  +  + QK++            E+S E +   ERD
Sbjct: 2137 RDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERD 2196

Query: 220  DLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQR---QLLAERK----RAYEAHDENK 272
             + +K    E ++ + E ++++  + LE      Q+   QL  ++K    R  E   ENK
Sbjct: 2197 AIDRK----EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK 2252

Query: 273  VLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKG 332
            + + ++++L   +KE +               +   +++ +   K       FA +  + 
Sbjct: 2253 LFKDDMEKLGLAIKESD---------------AMSTQDQHVLFGK-------FAQIIQEK 2290

Query: 333  VQTMEDFKPEEYPLTPETIMCYENK-WEEPGHLTLDLQSQ-----------KQDRHGEAG 380
               ++    +   L  +  +  +NK  EE   L  DL++Q           K++R  E  
Sbjct: 2291 EVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIE 2350

Query: 381  ILNPIMEREEKFV------TDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREE 432
             LN ++E+ ++ +      T    H + +E + L     + +LD    EK +L ++ E
Sbjct: 2351 QLNEVIEKLQQELANIGQKTSMNAHSLSEEADSL-----KHQLDVVIAEKLALEQQVE 2403



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 84/393 (21%), Positives = 162/393 (41%), Gaps = 37/393 (9%)

Query: 78   GVRVGFRSQSLNREP--LRKDTDLVT--KRILSARLLKINE----LQNEVSELQVKLAEL 129
            G +    + SL+ E   L+   D+V   K  L  ++   NE    ++N + E   K+ +L
Sbjct: 2367 GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQL 2426

Query: 130  LKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEI-TALKERLRKSQEKERATEKR 188
             +E  SLKR +   EK  +  E++ N     + +   E+   L E   KS E +   +  
Sbjct: 2427 TQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF 2486

Query: 189  VKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVS----AELKLDDTERRIKELSK 244
             ++ +  +   +  L +L+    A+ L E     K++       + + +  +++I  L K
Sbjct: 2487 EENGKGSIINLETRLLQLESTVSAKDL-ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQK 2545

Query: 245  NLELSTNSF---QRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNR 301
             +E    +    Q QL A ++ A    D N+ +  E +R   +   + RE ++ +  S  
Sbjct: 2546 IVEEKVAAALVSQIQLEAVQEYAKFCQD-NQTISSEPERTNIQNLNQLREDELGSDISAL 2604

Query: 302  LPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTP--ETIMCYENKWE 359
              + S  + + + +  +   + +  ++  K V   E    E   L    E     + K  
Sbjct: 2605 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2664

Query: 360  EPGHL-TLDLQSQKQDRHGEAGILNPIME-REEKFVTDEELHVVKQEVEKLEDEWEREEL 417
             P  +  L   ++    + E+G  N +   R E   T  EL   K++ EKL++E   +E 
Sbjct: 2665 SPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKET 2724

Query: 418  DK---------------KQKEKASLLEREEKPE 435
            +                + KEK S+LE+E++ E
Sbjct: 2725 NMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2757



 Score = 37.0 bits (84), Expect = 0.062
 Identities = 75/370 (20%), Positives = 160/370 (43%), Gaps = 62/370 (16%)

Query: 111  KINELQNE-VSELQVKLAELLKENKSLKRLQYRQEKALNK-FEDAENEISQL-------- 160
            K+ E +NE + +L+ ++  L+ + + +KR +  + + LN+  E  + E++ +        
Sbjct: 2315 KVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNA 2374

Query: 161  --------IFRHNNEITALKERLRKSQEKERATEKR------VKDTE---SELFRTKFSL 203
                      +H  ++  + E+L   Q+ E A E+       +K+T    ++L +  FSL
Sbjct: 2375 HSLSEEADSLKHQLDVV-IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2433

Query: 204  QKLKE-ISEARHLPER------DDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQ 256
            ++ +E + + + +PE       D L+K     E+ L +   +  E     +    + +  
Sbjct: 2434 KRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGS 2493

Query: 257  LLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALR 316
            ++    R  +          E+ + Y ++K+ + +   +   +  L K   N +K +  +
Sbjct: 2494 IINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFE---TEMLQKKIVNLQKIVEEK 2550

Query: 317  KNAACQS--------DFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTL-- 366
              AA  S        ++A  C    QT+   +PE   +     +  +    +   LTL  
Sbjct: 2551 VAAALVSQIQLEAVQEYAKFCQDN-QTISS-EPERTNIQNLNQLREDELGSDISALTLRI 2608

Query: 367  -DLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKA 425
             +L+SQ  + H        I+E+E+  V   E +V+++E + LE +   E  +KKQ+EK 
Sbjct: 2609 SELESQVVEMHTSL-----ILEKEQ--VEIAEKNVLEKEKKLLELQKLLEGNEKKQREK- 2660

Query: 426  SLLEREEKPE 435
               E++  P+
Sbjct: 2661 ---EKKRSPQ 2667



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 83/412 (20%), Positives = 169/412 (41%), Gaps = 59/412 (14%)

Query: 109  LLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKA-------------LNKFEDAE- 154
            L K+ E  N++  LQ +L+++  +     +L++ +E               +   ED + 
Sbjct: 1260 LNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDV 1319

Query: 155  NEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQK-LKEISEAR 213
            N  S+L    + E T L+E++++ +    + ++++K+TE         LQK L+ +SE+ 
Sbjct: 1320 NHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSEST 1379

Query: 214  HLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKV 273
              P        +V  E     T      + KN++  T  F  +   +     E  +  K+
Sbjct: 1380 VPPSLP--VDSVVITESDAQRTMYPGSCVKKNID-GTIEFSGEFGVK-----EETNIVKL 1431

Query: 274  LQKEVQ-RLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRK-NAACQSD---FADL 328
            L+K+ Q +L  ++ +    + I       L + S  KE   + ++ +A CQ +   F ++
Sbjct: 1432 LEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEM 1491

Query: 329  CTK----GVQTME----DFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAG 380
                   G QT E     FK E  PL+           +E G    ++     D H    
Sbjct: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLS-----------KELGEHGKEILLSNSDPHDIPE 1540

Query: 381  ILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGR 440
              + ++   E+  + ++  +V+Q +    DE     +D  ++   +  + E+  +    +
Sbjct: 1541 SKDCVLTISEEMFSKDKTFIVRQSI---HDEISVSSMDASRQLMLNEEQLEDMRQELVRQ 1597

Query: 441  YQ--------LGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNL 484
            YQ        L    ++ M++ Q E++E+L+ E+         R   D+ NL
Sbjct: 1598 YQEHQQATELLRQAHMRQMER-QREDQEQLQEEIKRLNRQLAQRSSIDNENL 1648



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 36/174 (20%), Positives = 75/174 (43%), Gaps = 12/174 (6%)

Query: 45   SVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNRE-----PLRKDTDL 99
            S ++   +R   D Q+  +  R    + L   + VR+   S +L+RE      L+     
Sbjct: 3273 SQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGT 3332

Query: 100  VTKR--ILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEI 157
               R  + S  LLK  ELQ ++ E   ++ ELL E +  K    +  + + K      + 
Sbjct: 3333 GQSRPPLPSEDLLK--ELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3390

Query: 158  SQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISE 211
             Q     N E    ++++ + Q K    ++++++   ++++     Q+L+ I +
Sbjct: 3391 LQTEQEANTE---GQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ 3441



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 82/435 (18%), Positives = 182/435 (41%), Gaps = 67/435 (15%)

Query: 114  ELQNEVSELQVKLAELLKENKSLKRLQYRQE-KALNK------------------FEDAE 154
            ELQ E + L +K+ + L+++K+ + L+Y+ + KALN+                  F++ +
Sbjct: 863  ELQEEYACL-LKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921

Query: 155  NEISQLIFRHN---NEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISE 211
              +++ +        + T L E+L  ++ ++    +R+ D   +L +    +  L E  E
Sbjct: 922  TFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNE--E 979

Query: 212  ARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAH--- 268
             + L +  +    L   EL++     R + + ++ +   +S    ++    R  E     
Sbjct: 980  VKSLKQEKEQVS-LRCRELEIIINHNRAENV-QSCDTQVSSLLDGVVTMTSRGAEGSVSK 1037

Query: 269  ------DENKVLQKE---VQRLYHKLKEKERELDIKNIYS--------NRLPKSSPNKEK 311
                  +E+K++ ++    + +    + K+ +L + ++ S           P  +   +K
Sbjct: 1038 VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQK 1097

Query: 312  ELALRKNAA----CQSDFADLCTKGVQTMEDFKPEEY----------PLTPETIMCYENK 357
            EL + K+       Q +   +C   V +    +  EY           L  E I   E K
Sbjct: 1098 ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK 1157

Query: 358  WEEPGHL-TLDLQSQKQDRHGEAGI-LNPIMEREEKFVTDEELHVVKQEVEKLEDEWE-- 413
             +E   +  L+LQ+ K    G+ G  L+ ++ + +K V++E  + ++     L + +   
Sbjct: 1158 IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPA 1217

Query: 414  -REELDKKQKEKAS-LLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKL 471
             + E++ + KE +   +   E PE +  RY++  +       L    EE  K  +L  +L
Sbjct: 1218 LKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRL 1277

Query: 472  NEIDRELQDSRNLKY 486
            ++I  +  D   L++
Sbjct: 1278 SKIWGQQTDGMKLEF 1292



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 50/228 (21%), Positives = 95/228 (41%), Gaps = 45/228 (19%)

Query: 105  LSARLLKINELQNEVSEL---------QVKLAE--LLKENKSLKRLQYRQEKALNKFEDA 153
            +SA  L+I+EL+++V E+         QV++AE  +L++ K L  LQ   E    K  + 
Sbjct: 2601 ISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2660

Query: 154  ENEISQL----------IFRHN------NEITAL--------------KERLRKSQEKER 183
            E + S            +F  N      NE+ AL              KE+  K QE+  
Sbjct: 2661 EKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL 2720

Query: 184  ATEKRVKDTESELFRTKFSLQKLKE---ISEARHLPERDDLAKKLVSAELKLDDTERRIK 240
              E  +   + +L + +  L + KE   I E     E  +  K  +   L +  ++    
Sbjct: 2721 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIAS 2780

Query: 241  ELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEK 288
            +    L++S+++   Q+L  +    + + +++   +EV  +  +  EK
Sbjct: 2781 QTDGTLKISSSNQTPQILV-KNAGIQINLQSECSSEEVTEIISQFTEK 2827


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 105/491 (21%), Positives = 202/491 (41%), Gaps = 76/491 (15%)

Query: 35  RSSLVSSSPASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLR 94
           R+S  SS+ A + +   +  T   Q+  Q       +       +++ F  + +    + 
Sbjct: 252 RNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEME 311

Query: 95  KDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAE 154
           +D     K++ ++   +I E +  + EL  K+ E  K+   LK      +K L       
Sbjct: 312 QD-----KKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLG------ 360

Query: 155 NEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARH 214
            E+ + I + N EI  +K  L  S++KER + + +K    +L  T   LQK       + 
Sbjct: 361 -ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIK----QLMGTVEELQKRNH----KD 411

Query: 215 LPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDE---- 270
                D+ +++        +T+R++++L   L+        Q+  E  R + A  E    
Sbjct: 412 SQFETDIVQRME------QETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKT 465

Query: 271 -NKVLQKEVQRLYHKLKEKERELDIKNIYSNRL---------PKSSPNKEKELALRKNAA 320
            +K   +   R Y  +   E ++ + N+  N L          K    +E  L L +  A
Sbjct: 466 RHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCA 525

Query: 321 CQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTL----DLQSQ----- 371
            Q    DL  +       F  E+     +TI   E+K  E  H +L    DL+++     
Sbjct: 526 LQRQLEDLVEE-----LSFSREQIQRARQTIAEQESKLNE-AHKSLSTVEDLKAEIVSAS 579

Query: 372 ----KQDRHGEAGILN-----PIMEREEKFVTDEELHVVKQEVEKLEDEW---EREELDK 419
               + +   EA + N      ++E+E+  V D      + E+E+L  +      EEL K
Sbjct: 580 ESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSK 639

Query: 420 KQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERL-----KREMLLAKLNEI 474
            +++    LE E +   E  +  LG++  Q +D LQ E  +++     +++ L+ K N++
Sbjct: 640 LKED----LEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQL 695

Query: 475 DRELQDSRNLK 485
             E+   ++L+
Sbjct: 696 ILEISKLKDLQ 706



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 91/389 (23%), Positives = 171/389 (43%), Gaps = 68/389 (17%)

Query: 141  YRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQ------EKERATEKRVKDT-- 192
            Y  EK L  FE    E + +I R   E+     RL++ +      ++ER    R K+   
Sbjct: 1927 YADEKTL--FERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMK 1984

Query: 193  ------ESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELS--K 244
                  E +L +    L K K   + +    RDDL K++ + E+ +++   R  EL   K
Sbjct: 1985 AEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEK 2044

Query: 245  NLEL-----STNSFQRQLLAERK----RAYEAHDENKVLQKEVQRLYHKLKEKERELDIK 295
            N EL        + ++QL   RK    +A +   E  V Q+E+Q+L  +LK   R   I 
Sbjct: 2045 NTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPIS 2104

Query: 296  NIYSNRLP------KSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPE 349
               +  +       K   +K  EL L K    Q D  +   + ++ +E F+  E     +
Sbjct: 2105 EHQTREVEQLANHLKEKTDKCSELLLSKE-QLQRDIQER-NEEIEKLE-FRVRE---LEQ 2158

Query: 350  TIMCYENKW----EEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVT--DEELHVVKQ 403
             ++  + K     E    L+L++Q Q +            ++R+EK +T  +E+L   ++
Sbjct: 2159 ALLVEDRKHFGAVEAKPELSLEVQLQAE---------RDAIDRKEKEITNLEEQLEQFRE 2209

Query: 404  EVEKLEDEWER--EELDKKQKEKASLLE--REEKPEWETGRYQLGMYPIQNMDKLQGEEE 459
            E+E   +E ++   +L+ ++KE  + L+   +E   ++    +LG+  I+  D +  +++
Sbjct: 2210 ELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGL-AIKESDAMSTQDQ 2268

Query: 460  ERL---------KREMLLAKLNEIDRELQ 479
              L         ++E+ + +LNE   +LQ
Sbjct: 2269 HVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2297



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 86/403 (21%), Positives = 164/403 (40%), Gaps = 75/403 (18%)

Query: 119  VSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKS 178
            +SE+Q   A++     +LKR Q  ++ +    E    +    +     E++++K+R  + 
Sbjct: 3083 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3142

Query: 179  QEKERATEKRVKDTESELFRTKFSLQ--------KLKEISEARHLPERD----------- 219
            QE+  + +  V + +SEL +TK  L+         LKE+ EA  L  +D           
Sbjct: 3143 QEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL-EAFRLEVKDKTDEVHLLNDT 3201

Query: 220  ---------DLAKKLVSAELKLDDTERRIKELSKNLELSTNS-----FQRQLLAERKRAY 265
                     +L   L   + KL  +E R KE  ++L+ S  S      Q  LL E+++  
Sbjct: 3202 LASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQL 3261

Query: 266  EAHDENKVLQKEVQRLYHKL---KEKERELDIKNIYSN-----RLPKSSPNKEKELALRK 317
                + K+   E QR+ +     +E+ R L+++ +  +     R   S+ ++E+EL    
Sbjct: 3262 LNESQQKI---ESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDREREL---- 3314

Query: 318  NAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHG 377
            +A  QS      ++     ED   E      E          E     LD    +Q    
Sbjct: 3315 HAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEK 3374

Query: 378  EAGILNPIMEREEKFVTD--EELHVVKQEVEKLEDEWERE-----ELDKKQKEKASLLER 430
            +  +    ++ E++  T+  +++H ++ +VE L+ + E +     +LD + +    +++ 
Sbjct: 3375 DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQE 3434

Query: 431  EEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNE 473
             +K E E                    EE+R  R +L   LNE
Sbjct: 3435 FQKQELE-------------------REEKRESRRILYQNLNE 3458



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 65/326 (19%), Positives = 130/326 (39%), Gaps = 29/326 (8%)

Query: 110  LKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEIT 169
            L+INELQ E+  L+ +  E     + ++ LQ + E    + ++ EN++ +   +   E +
Sbjct: 719  LQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778

Query: 170  ALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEAR---HLPERDDLAKKLV 226
             LK+  +K+ E        V   E  +F      +    + E      + E +DL ++ +
Sbjct: 779  ILKDE-KKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCI 837

Query: 227  SAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLK 286
                +++          KN E++    Q +     K   +  D     + E +    KLK
Sbjct: 838  QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK---SKLK 894

Query: 287  EKERELDIKNIYSNRLP-KSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYP 345
                EL ++ I    +  KSS   E +  + +            T+ ++ +E  K E+  
Sbjct: 895  ALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLE 954

Query: 346  LTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIME--REEKFVTDEELHVVKQ 403
            L+                   DL  Q + +HGE   LN  ++  ++EK    E++ +  +
Sbjct: 955  LSQR---------------LSDLSEQLKQKHGEISFLNEEVKSLKQEK----EQVSLRCR 995

Query: 404  EVEKLEDEWEREELDKKQKEKASLLE 429
            E+E + +    E +     + +SLL+
Sbjct: 996  ELEIIINHNRAENVQSCDTQVSSLLD 1021



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 121/592 (20%), Positives = 244/592 (41%), Gaps = 106/592 (17%)

Query: 86  QSLNREPLRKDTDLVTKRILSARLLKINELQNEVSEL------QVKLAELLKENKSLKRL 139
           Q  N +  + +TD+V +R+      K+ +L+ E+ E+      Q+K   + +    ++ +
Sbjct: 405 QKRNHKDSQFETDIV-QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEM 463

Query: 140 QYRQ----EKALNKFED-------------AENEISQLIFRHNNEITALKERLRKSQEKE 182
           + R     E AL  + +             A NE++  +   N++   LKE L    E++
Sbjct: 464 KTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEK 523

Query: 183 RATEKRVKDTESELFRTKFSLQKLKE--------ISEA-RHLPERDDLAKKLVSAELKLD 233
            A +++++D   EL  ++  +Q+ ++        ++EA + L   +DL  ++VSA     
Sbjct: 524 CALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSAS---- 579

Query: 234 DTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELD 293
              R+  EL    E++    + ++L + K        N VL +  +    +L+    +L 
Sbjct: 580 -ESRKELELKHEAEVTNYKIKLEMLEKEK--------NAVLDRMAESQEAELERLRTQL- 629

Query: 294 IKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTK----GVQTMEDFKPEEYPLTPE 349
              ++S+    S   ++ E+  R N     D   +  K    G+Q     K E      +
Sbjct: 630 ---LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD 686

Query: 350 TIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILN--------PIMEREEKFVTDEELHVV 401
            ++  +N+         DLQ    +   E   L          I+ +EEK     E   +
Sbjct: 687 NLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK-----EKGTL 741

Query: 402 KQEVEKLEDEWEREELDKKQKEKAS-LLEREEKPEWETGRYQLGMYPIQNMDKLQ---GE 457
           +QEV++L+   + E L+K+ KEK + L E+  + E E    +     +++M K+     +
Sbjct: 742 EQEVQELQ--LKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQ 799

Query: 458 EEERLKREMLLAKL------NEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRF 511
           EE  +  + + +K        EI+  ++++ +LK   + L  +        E+   T+ F
Sbjct: 800 EERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEI-------EKQRNTFSF 852

Query: 512 SESSERLFNGHHLQ-----------DISFSTPKGEGQNSGNVRSPASPNEFAFGSYVPSF 560
           +E +  + N   LQ           D+  S  K E +    ++  A   E       P+ 
Sbjct: 853 AEKNFEV-NYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLK--ALNEELHLQRINPTT 909

Query: 561 AKTSERSNPFSQKSSFLDFQRNSMEKLSKDGVDLITR----KEKKANLMEQL 608
            K   +S+ F +  +F+       E + KD  +L+ +    K +K  L ++L
Sbjct: 910 VKM--KSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRL 959



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 72/350 (20%), Positives = 147/350 (42%), Gaps = 64/350 (18%)

Query: 116  QNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERL 175
            ++E    Q ++ +L ++ K + R Q   E    + E   N + +   + +  + + ++  
Sbjct: 2077 EHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQ 2136

Query: 176  RKSQEKERATEK---RVKDTESELF---RTKFSLQKLK-EIS-EARHLPERDDLAKKLVS 227
            R  QE+    EK   RV++ E  L    R  F   + K E+S E +   ERD + +K   
Sbjct: 2137 RDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRK--- 2193

Query: 228  AELKLDDTERRIKELSKNLELSTNSFQR---QLLAERK----RAYEAHDENKVLQKEVQR 280
             E ++ + E ++++  + LE      Q+   QL  ++K    R  E   ENK+ + ++++
Sbjct: 2194 -EKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEK 2252

Query: 281  LYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFK 340
            L   +KE +               +   +++ +   K       FA +  +    ++   
Sbjct: 2253 LGLAIKESD---------------AMSTQDQHVLFGK-------FAQIIQEKEVEIDQLN 2290

Query: 341  PEEYPLTPETIMCYENK-WEEPGHLTLDLQSQ-----------KQDRHGEAGILNPIMER 388
             +   L  +  +  +NK  EE   L  DL++Q           K++R  E   LN ++E+
Sbjct: 2291 EQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEK 2350

Query: 389  EEKFV------TDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREE 432
             ++ +      T    H + +E + L     + +LD    EK +L ++ E
Sbjct: 2351 LQQELANIGQKTSMNAHSLSEEADSL-----KHQLDVVIAEKLALEQQVE 2395



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 84/393 (21%), Positives = 162/393 (41%), Gaps = 37/393 (9%)

Query: 78   GVRVGFRSQSLNREP--LRKDTDLVT--KRILSARLLKINE----LQNEVSELQVKLAEL 129
            G +    + SL+ E   L+   D+V   K  L  ++   NE    ++N + E   K+ +L
Sbjct: 2359 GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQL 2418

Query: 130  LKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEI-TALKERLRKSQEKERATEKR 188
             +E  SLKR +   EK  +  E++ N     + +   E+   L E   KS E +   +  
Sbjct: 2419 TQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF 2478

Query: 189  VKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVS----AELKLDDTERRIKELSK 244
             ++ +  +   +  L +L+    A+ L E     K++       + + +  +++I  L K
Sbjct: 2479 EENGKGSIINLETRLLQLESTVSAKDL-ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQK 2537

Query: 245  NLELSTNSF---QRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNR 301
             +E    +    Q QL A ++ A    D N+ +  E +R   +   + RE ++ +  S  
Sbjct: 2538 IVEEKVAAALVSQIQLEAVQEYAKFCQD-NQTISSEPERTNIQNLNQLREDELGSDISAL 2596

Query: 302  LPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTP--ETIMCYENKWE 359
              + S  + + + +  +   + +  ++  K V   E    E   L    E     + K  
Sbjct: 2597 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKR 2656

Query: 360  EPGHL-TLDLQSQKQDRHGEAGILNPIME-REEKFVTDEELHVVKQEVEKLEDEWEREEL 417
             P  +  L   ++    + E+G  N +   R E   T  EL   K++ EKL++E   +E 
Sbjct: 2657 SPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKET 2716

Query: 418  DK---------------KQKEKASLLEREEKPE 435
            +                + KEK S+LE+E++ E
Sbjct: 2717 NMTSLQKDLSQVRDHLAEAKEKLSILEKEDETE 2749



 Score = 37.0 bits (84), Expect = 0.062
 Identities = 75/370 (20%), Positives = 160/370 (43%), Gaps = 62/370 (16%)

Query: 111  KINELQNE-VSELQVKLAELLKENKSLKRLQYRQEKALNK-FEDAENEISQL-------- 160
            K+ E +NE + +L+ ++  L+ + + +KR +  + + LN+  E  + E++ +        
Sbjct: 2307 KVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNA 2366

Query: 161  --------IFRHNNEITALKERLRKSQEKERATEKR------VKDTE---SELFRTKFSL 203
                      +H  ++  + E+L   Q+ E A E+       +K+T    ++L +  FSL
Sbjct: 2367 HSLSEEADSLKHQLDVV-IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSL 2425

Query: 204  QKLKE-ISEARHLPER------DDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQ 256
            ++ +E + + + +PE       D L+K     E+ L +   +  E     +    + +  
Sbjct: 2426 KRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGS 2485

Query: 257  LLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALR 316
            ++    R  +          E+ + Y ++K+ + +   +   +  L K   N +K +  +
Sbjct: 2486 IINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFE---TEMLQKKIVNLQKIVEEK 2542

Query: 317  KNAACQS--------DFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTL-- 366
              AA  S        ++A  C    QT+   +PE   +     +  +    +   LTL  
Sbjct: 2543 VAAALVSQIQLEAVQEYAKFCQDN-QTISS-EPERTNIQNLNQLREDELGSDISALTLRI 2600

Query: 367  -DLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKA 425
             +L+SQ  + H        I+E+E+  V   E +V+++E + LE +   E  +KKQ+EK 
Sbjct: 2601 SELESQVVEMHTSL-----ILEKEQ--VEIAEKNVLEKEKKLLELQKLLEGNEKKQREK- 2652

Query: 426  SLLEREEKPE 435
               E++  P+
Sbjct: 2653 ---EKKRSPQ 2659



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 83/412 (20%), Positives = 169/412 (41%), Gaps = 59/412 (14%)

Query: 109  LLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKA-------------LNKFEDAE- 154
            L K+ E  N++  LQ +L+++  +     +L++ +E               +   ED + 
Sbjct: 1260 LNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDV 1319

Query: 155  NEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQK-LKEISEAR 213
            N  S+L    + E T L+E++++ +    + ++++K+TE         LQK L+ +SE+ 
Sbjct: 1320 NHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSEST 1379

Query: 214  HLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKV 273
              P        +V  E     T      + KN++  T  F  +   +     E  +  K+
Sbjct: 1380 VPPSLP--VDSVVITESDAQRTMYPGSCVKKNID-GTIEFSGEFGVK-----EETNIVKL 1431

Query: 274  LQKEVQ-RLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRK-NAACQSD---FADL 328
            L+K+ Q +L  ++ +    + I       L + S  KE   + ++ +A CQ +   F ++
Sbjct: 1432 LEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEM 1491

Query: 329  CTK----GVQTME----DFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAG 380
                   G QT E     FK E  PL+           +E G    ++     D H    
Sbjct: 1492 KLSQDQIGFQTFETVDVKFKEEFKPLS-----------KELGEHGKEILLSNSDPHDIPE 1540

Query: 381  ILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGR 440
              + ++   E+  + ++  +V+Q +    DE     +D  ++   +  + E+  +    +
Sbjct: 1541 SKDCVLTISEEMFSKDKTFIVRQSI---HDEISVSSMDASRQLMLNEEQLEDMRQELVRQ 1597

Query: 441  YQ--------LGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNL 484
            YQ        L    ++ M++ Q E++E+L+ E+         R   D+ NL
Sbjct: 1598 YQEHQQATELLRQAHMRQMER-QREDQEQLQEEIKRLNRQLAQRSSIDNENL 1648



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 36/174 (20%), Positives = 75/174 (43%), Gaps = 12/174 (6%)

Query: 45   SVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNRE-----PLRKDTDL 99
            S ++   +R   D Q+  +  R    + L   + VR+   S +L+RE      L+     
Sbjct: 3265 SQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGT 3324

Query: 100  VTKR--ILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEI 157
               R  + S  LLK  ELQ ++ E   ++ ELL E +  K    +  + + K      + 
Sbjct: 3325 GQSRPPLPSEDLLK--ELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKT 3382

Query: 158  SQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISE 211
             Q     N E    ++++ + Q K    ++++++   ++++     Q+L+ I +
Sbjct: 3383 LQTEQEANTE---GQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQ 3433



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 82/435 (18%), Positives = 182/435 (41%), Gaps = 67/435 (15%)

Query: 114  ELQNEVSELQVKLAELLKENKSLKRLQYRQE-KALNK------------------FEDAE 154
            ELQ E + L +K+ + L+++K+ + L+Y+ + KALN+                  F++ +
Sbjct: 863  ELQEEYACL-LKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDK 921

Query: 155  NEISQLIFRHN---NEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISE 211
              +++ +        + T L E+L  ++ ++    +R+ D   +L +    +  L E  E
Sbjct: 922  TFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNE--E 979

Query: 212  ARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAH--- 268
             + L +  +    L   EL++     R + + ++ +   +S    ++    R  E     
Sbjct: 980  VKSLKQEKEQVS-LRCRELEIIINHNRAENV-QSCDTQVSSLLDGVVTMTSRGAEGSVSK 1037

Query: 269  ------DENKVLQKE---VQRLYHKLKEKERELDIKNIYS--------NRLPKSSPNKEK 311
                  +E+K++ ++    + +    + K+ +L + ++ S           P  +   +K
Sbjct: 1038 VNKSFGEESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQK 1097

Query: 312  ELALRKNAA----CQSDFADLCTKGVQTMEDFKPEEY----------PLTPETIMCYENK 357
            EL + K+       Q +   +C   V +    +  EY           L  E I   E K
Sbjct: 1098 ELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEK 1157

Query: 358  WEEPGHL-TLDLQSQKQDRHGEAGI-LNPIMEREEKFVTDEELHVVKQEVEKLEDEWE-- 413
             +E   +  L+LQ+ K    G+ G  L+ ++ + +K V++E  + ++     L + +   
Sbjct: 1158 IKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPA 1217

Query: 414  -REELDKKQKEKAS-LLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKL 471
             + E++ + KE +   +   E PE +  RY++  +       L    EE  K  +L  +L
Sbjct: 1218 LKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRL 1277

Query: 472  NEIDRELQDSRNLKY 486
            ++I  +  D   L++
Sbjct: 1278 SKIWGQQTDGMKLEF 1292



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 50/228 (21%), Positives = 95/228 (41%), Gaps = 45/228 (19%)

Query: 105  LSARLLKINELQNEVSEL---------QVKLAE--LLKENKSLKRLQYRQEKALNKFEDA 153
            +SA  L+I+EL+++V E+         QV++AE  +L++ K L  LQ   E    K  + 
Sbjct: 2593 ISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2652

Query: 154  ENEISQL----------IFRHN------NEITAL--------------KERLRKSQEKER 183
            E + S            +F  N      NE+ AL              KE+  K QE+  
Sbjct: 2653 EKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL 2712

Query: 184  ATEKRVKDTESELFRTKFSLQKLKE---ISEARHLPERDDLAKKLVSAELKLDDTERRIK 240
              E  +   + +L + +  L + KE   I E     E  +  K  +   L +  ++    
Sbjct: 2713 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIAS 2772

Query: 241  ELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEK 288
            +    L++S+++   Q+L  +    + + +++   +EV  +  +  EK
Sbjct: 2773 QTDGTLKISSSNQTPQILV-KNAGIQINLQSECSSEEVTEIISQFTEK 2819


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 67/334 (20%), Positives = 146/334 (43%), Gaps = 36/334 (10%)

Query: 113 NELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALK 172
           + L  E+  +  KL   ++EN+   RL  +QE+ + + E+   E  + I     +I   +
Sbjct: 256 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQE 315

Query: 173 ERLRKSQEKERATEKRVKDTES----------ELFRTKFSLQKLKEISEARHLPERDDLA 222
           E++R+ +E     E++++  E           EL       +K++E  E R   E+    
Sbjct: 316 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 375

Query: 223 KKLVSAELKLDDTERRIKELSKNLELSTNSFQRQ---LLAERKRAYEAHDENKVLQKEVQ 279
           +K    E K+   E +I+E  + +       Q Q   +  + ++ +E  +E +  +++++
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435

Query: 280 RLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDF 339
           R   K++E+E+++  +        +    +E+++  ++   C+ +      K  +  E  
Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQE-----AKMQEQEEKM 490

Query: 340 KPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELH 399
           + +E     E I   E K  E        Q +K     E      + E+EEK    EE  
Sbjct: 491 RRQE-----EKIREQEKKIRE--------QEEKIREQEEM-----MQEQEEKMWEQEEKM 532

Query: 400 VVKQEVEKLEDEWEREELDKKQKEKASLLEREEK 433
             ++E  + ++E  R + +K ++++  L ++EEK
Sbjct: 533 CEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 82/383 (21%), Positives = 174/383 (45%), Gaps = 52/383 (13%)

Query: 112 INELQNEVSELQVKLAELLKE----NKSLKRLQYRQEKALNKFEDAENE---ISQLIFRH 164
           + +L+ E  +L  +L +  K      ++L  +  +++KA    E+   E   +S  ++R+
Sbjct: 141 VKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRN 200

Query: 165 NNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLP-ERDDLAK 223
                 LKE+  K QEK +  E    + +  +   K  L++ K +   + L  E D L K
Sbjct: 201 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 260

Query: 224 KLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYH 283
           +L S   KL        ++ +N EL     Q+Q     ++ +   ++ +  ++++Q    
Sbjct: 261 ELQSVSAKLQ------AQVEEN-ELWNRLNQQQ----EEKMWRQEEKIQEREEKIQEQEE 309

Query: 284 KLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEE 343
           K++E+E ++        R  +    KE+++  ++    + +      + ++ +E+   E+
Sbjct: 310 KIREQEEKM-------RRQEEMMWEKEEKMRRQEEMMWEKE------EKIRELEEKMHEQ 356

Query: 344 YPLTPETIMCYENKWEEPGHLTLDLQSQKQD----RHGEAGILNPIMEREEKFVTDEELH 399
                E I   E K +E   +    + Q+Q+    R  E      I E+EEK    EE+ 
Sbjct: 357 -----EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK-----IREQEEKIREQEEMM 406

Query: 400 VVKQEV--EKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGE 457
             ++E   E+ E  WE+EE  ++Q+EK  +  +EEK   +  + +     I+  +++  E
Sbjct: 407 QEQEEKMGEQEEKMWEQEEEMQEQEEK--MRRQEEKIREQEKKIREQEEKIREQEEMMQE 464

Query: 458 EEERLKREMLLAKLNEIDRELQD 480
           +EE++  +    K+ E + ++Q+
Sbjct: 465 QEEKMGEQE--GKMCEQEAKMQE 485



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 71/325 (21%), Positives = 142/325 (43%), Gaps = 42/325 (12%)

Query: 172 KERLRKSQEKERATEKRVKDTESEL-FRTKFSLQKLKEIS-EARHLPER--------DDL 221
           +E LR+  E +  T + +   ++EL     +S   +K++  EAR L  R         +L
Sbjct: 106 QEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGEL 165

Query: 222 AKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRL 281
            + L +   +    +R I+EL+K  +  +    R  + +     E  ++N  LQ+++Q +
Sbjct: 166 EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE----ELKEKNAKLQEKLQLV 221

Query: 282 YHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKP 341
             + ++ E +L++K +      K    + K L  ++    ++D      + V      + 
Sbjct: 222 --ESEKSEIQLNVKEL------KRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQV 273

Query: 342 EEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVV 401
           EE  L        E K         + + + Q++  +      I E+EEK    EE+   
Sbjct: 274 EENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEK------IREQEEKMRRQEEMMWE 327

Query: 402 KQEVEKLEDE--WEREE----LDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQ 455
           K+E  + ++E  WE+EE    L++K  E+  + E+EEK + E          I+  +K Q
Sbjct: 328 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE--------KIREQEKRQ 379

Query: 456 GEEEERLKREMLLAKLNEIDRELQD 480
            +E +  ++E  + +  E  RE ++
Sbjct: 380 EQEAKMWRQEEKIREQEEKIREQEE 404



 Score = 37.0 bits (84), Expect = 0.062
 Identities = 30/182 (16%), Positives = 84/182 (46%), Gaps = 19/182 (10%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           KI E +  + E + K+ E  ++    +     QE+ + + E+   E  + I     +I  
Sbjct: 398 KIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 457

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAEL 230
            +E +++ +EK    E ++ + E+++   +  +++ +E               K+   E 
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE---------------KIREQEK 502

Query: 231 KLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKER 290
           K+ + E +I+E  + ++      + ++  + ++  E  ++ +  +++++R   K++E+E 
Sbjct: 503 KIREQEEKIREQEEMMQ----EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEV 558

Query: 291 EL 292
            L
Sbjct: 559 RL 560



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 22/153 (14%), Positives = 74/153 (48%), Gaps = 8/153 (5%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           K+ E + E+ E + K+    ++ +  ++    QE+ + + E+   E  + +     ++  
Sbjct: 419 KMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCE 478

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAEL 230
            + ++++ +EK R  E+++++ E ++   +  +++ +E+ + +         +K+   E 
Sbjct: 479 QEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE--------EKMWEQEE 530

Query: 231 KLDDTERRIKELSKNLELSTNSFQRQLLAERKR 263
           K+ + E +++E  + +       + Q +  R++
Sbjct: 531 KMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQ 563



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 25/146 (17%), Positives = 71/146 (48%), Gaps = 8/146 (5%)

Query: 114 ELQNEVSELQVKLAELLKENKSLKRLQYR---QEKALNKFEDAENEISQLIFRHNNEITA 170
           E+Q +  +++ +  ++ ++ K ++  + +   QE+ + + E+   E    +     ++  
Sbjct: 426 EMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQE 485

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE--ISEARHLPERDDLAKKLVSA 228
            +E++R+ +EK R  EK++++ E ++   +  +Q+ +E    +   + E+++   K+   
Sbjct: 486 QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE---KMQEQ 542

Query: 229 ELKLDDTERRIKELSKNLELSTNSFQ 254
           E K+   E +++E    L       Q
Sbjct: 543 EEKMRRQEEKMREQEVRLRQQEEKMQ 568



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 17/98 (17%), Positives = 51/98 (52%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           K+ E + ++ E + K+ E  ++ +  +     QEK + + E+   E  +++     ++  
Sbjct: 468 KMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 527

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE 208
            +E++ + +EK +  E++++  E ++   +  L++ +E
Sbjct: 528 QEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEE 565


>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
          Length = 1233

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 107/446 (23%), Positives = 200/446 (44%), Gaps = 58/446 (13%)

Query: 107 ARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNN 166
           AR++     + +++   V+L E  +E + L  L     KA N F   +  +  +  ++  
Sbjct: 95  ARVIVGGSSEYKINNKVVQLHEYSEELEKLGILI----KARN-FLVFQGAVESIAMKNPK 149

Query: 167 EITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEIS----EARHLPE----- 217
           E TAL E + +S E  +  +KR K+       T+F+  + K I+    EA+   E     
Sbjct: 150 ERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRY 209

Query: 218 ---RDDLAKKLVSAEL-KLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKV 273
              +D++ +  V  +L KL   E  I++L+K L     S  +++  ++KR  +  DE K 
Sbjct: 210 QRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELA----SKNKEIEKDKKRMDKVEDELKE 265

Query: 274 LQKEV-------QRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFA 326
            +KE+       Q++  ++KEK+ EL+ K     +  +++ +K K+L   K +   +   
Sbjct: 266 KKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKH 325

Query: 327 DLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGH-----LTLDLQSQKQDRH---GE 378
               KG   M++ + E   +  +    +E + EE        LTL+ ++Q +  H    E
Sbjct: 326 YKKRKG--DMDELEKEMLSV-EKARQEFEERMEEESQSQGRDLTLE-ENQVKKYHRLKEE 381

Query: 379 AGILNPIMERE-EKFVTDEELHVVKQEVEKLE-DEWEREELDKKQKEKASLLEREEKPEW 436
           A      + +E EKF  D+     K + ++L+ +E ++ E + K K+K   +E  +K   
Sbjct: 382 ASKRAATLAQELEKFNRDQ-----KADQDRLDLEERKKVETEAKIKQKLREIEENQKRIE 436

Query: 437 ETGRY-QLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDF 495
           +   Y       ++   KL+GE  E +  EM   +++EI++EL         V+  L D 
Sbjct: 437 KLEEYITTSKQSLEEQKKLEGELTEEV--EMAKRRIDEINKELNQ-------VMEQLGDA 487

Query: 496 ESKLHSPERSPKTYRFSESSERLFNG 521
                   R  +     ES +RL+ G
Sbjct: 488 RIDRQESSRQQRKAEIMESIKRLYPG 513



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 66/345 (19%), Positives = 145/345 (42%), Gaps = 26/345 (7%)

Query: 47  RRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTKRILS 106
           R+K   +   D Q ++   +  + +    ++      R Q L  E +R    L       
Sbjct: 171 RKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQL------- 223

Query: 107 ARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNN 166
            +L K+   + E+ +L  +LA    +NK +++ + R +K  ++ ++ + E+ +++     
Sbjct: 224 -QLFKLYHNEVEIEKLNKELAS---KNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQ 279

Query: 167 EITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISE--ARHLPERDDLAKK 224
               +KE+  +  +K     K  ++T  ++ + + + + L+   +   +   + D+L K+
Sbjct: 280 IEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKE 339

Query: 225 LVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHK 284
           ++S E    + E R++E S++        + Q+    +   EA      L +E+++    
Sbjct: 340 MLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRD 399

Query: 285 LKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEY 344
            K  +  LD++     ++   +  K+K   + +N        +  T   Q++E+ K  E 
Sbjct: 400 QKADQDRLDLEE--RKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEG 457

Query: 345 PLTPETIMCYE-----NK-----WEEPGHLTLDLQ-SQKQDRHGE 378
            LT E  M        NK      E+ G   +D Q S +Q R  E
Sbjct: 458 ELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAE 502



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 67/346 (19%), Positives = 159/346 (45%), Gaps = 48/346 (13%)

Query: 102  KRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLI 161
            KRI+ +R  ++ +L+ ++++++ ++ E       ++ ++  +E+ + +    +NEI++  
Sbjct: 752  KRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVKR----QNEIAKKR 807

Query: 162  FRHNNEITAL-------KERLRKSQEKERATEKRVKDTESELFRTKFSLQK-LKEISEAR 213
                N+ T L       K +L++ Q+K    E+ VK  E+E+ + K   Q+ +K I E  
Sbjct: 808  LEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDET- 866

Query: 214  HLPERDDLAKKLVSAELKLDDTERRIKELSKNL---ELSTNSFQRQLLA-ERKRAYEAHD 269
             + +  DL  + ++ + +++D    ++E+ K L          Q+++ A E K   +  D
Sbjct: 867  -MAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSD 925

Query: 270  ENKVLQK-EVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELA--LRKNAACQSDFA 326
             + +LQ  ++Q +   L +   + DI     +   + S +  + ++    + A  + D+ 
Sbjct: 926  RHNLLQACKMQDIKLPLSKGTMD-DISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYG 984

Query: 327  DLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIM 386
            DLC    + ++D + EE                    +  ++ + +Q  + +  +L  I 
Sbjct: 985  DLC----EDLKDAQAEE-------------------EIKQEMNTLQQKLNEQQSVLQRIA 1021

Query: 387  EREEKFVTDEELHVVKQEVEKLEDEWE-REELDKKQKEKASLLERE 431
                K +  E+L  V+ + ++  DE+E   +  KK K+    +++E
Sbjct: 1022 APNMKAM--EKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKE 1065



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 76/388 (19%), Positives = 153/388 (39%), Gaps = 85/388 (21%)

Query: 111  KINELQNEVSELQVKLAEL---LKENKSLKRLQYRQEKA-----LNKFEDAENEISQLIF 162
            ++ ++Q++   LQ++L      L++ K+       QEK+     L  F    N+I ++I 
Sbjct: 697  ELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQ 756

Query: 163  RHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLA 222
                E+  LKE++ +           V+D   E F  +  ++ ++E  E + +  ++++A
Sbjct: 757  SREREMKDLKEKMNQ-----------VEDEVFEEFCREIGVRNIREFEEEK-VKRQNEIA 804

Query: 223  KKLVSAE-------LKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKV-- 273
            KK +  E       ++LD  + ++KE    + +   + ++             DEN++  
Sbjct: 805  KKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKK-------------DENEIEK 851

Query: 274  LQKEVQRLYHKLKEKEREL-DIKNIY-SNRLPKSSPNKEKELALRKNAACQSDFADLCTK 331
            L+KE QR    + E   +L D+KN + + +   +  N E E   +K      +   L   
Sbjct: 852  LKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHL--- 908

Query: 332  GVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEK 391
                             + +   E K          L+ ++ DRH    +L     ++ K
Sbjct: 909  ----------------QKEVTAIETK----------LEQKRSDRHN---LLQACKMQDIK 939

Query: 392  FVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNM 451
                +       ++ + E   + E+     +  +S+  RE   E + G         +++
Sbjct: 940  LPLSKG---TMDDISQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDL------CEDL 990

Query: 452  DKLQGEEEERLKREMLLAKLNEIDRELQ 479
               Q EEE + +   L  KLNE    LQ
Sbjct: 991  KDAQAEEEIKQEMNTLQQKLNEQQSVLQ 1018



 Score = 35.0 bits (79), Expect = 0.24
 Identities = 55/303 (18%), Positives = 128/303 (42%), Gaps = 41/303 (13%)

Query: 144 EKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTK--- 200
           EKA++K ++ +  +++ + +   +    +  LR+ Q +    + R+K ++S+L +TK   
Sbjct: 668 EKAVDKLKEKKERLTEEL-KEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRH 726

Query: 201 --FSLQKLKEISE--ARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQ 256
              +LQ+  ++    A   P  +D+ + + S E ++ D + ++ ++   +      F R+
Sbjct: 727 LALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEV---FEEFCRE 783

Query: 257 LLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALR 316
           +     R +E  +E    Q E+ +   + + ++  L I+  +     K   +K       
Sbjct: 784 IGVRNIREFE--EEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHM---- 837

Query: 317 KNAACQSDFADLCTKGVQTMEDFKPEE---YPLTPETIMCYENKWEEPGHLTLDLQSQKQ 373
                   +     K    +E  K EE     +  ET+   +           DL++Q  
Sbjct: 838 --------WEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQ-----------DLKNQHL 878

Query: 374 DRHGEAGILNPIMEREEKFV--TDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLERE 431
            +  E    N  ME   K +   ++E+  +++EV  +E + E++  D+    +A  ++  
Sbjct: 879 AKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDI 938

Query: 432 EKP 434
           + P
Sbjct: 939 KLP 941


>gi|8922950 meiosis-specific nuclear structural 1 [Homo sapiens]
          Length = 495

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 100/403 (24%), Positives = 180/403 (44%), Gaps = 66/403 (16%)

Query: 115 LQNEVSELQVKLA-ELLKENKSLKRLQYRQEKALN------KFEDAENEISQLIFRHNN- 166
           LQNE  EL ++ A +  +ENK LK LQ +QE+ L       K E  ++E  +   R N+ 
Sbjct: 60  LQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSI 119

Query: 167 EITALKERLRKS-QEKERATEKRVKDT--------ESELFRTKFSLQK--LKEISEARHL 215
           E+  L+++L+ +   KERA +   KD         ++E+ +T     K  +KE + A   
Sbjct: 120 ELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDK 179

Query: 216 PERD------DLAKKLVSAELKLDDT-ERRIKELSKNLELSTNSFQRQLLAERKRAYEAH 268
             +       DL K+L   E K  +  E+ +KE     E+    ++   L ++++  + +
Sbjct: 180 RNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMN 239

Query: 269 DENKVLQ--KEVQRLYHKLKEKERELDIKNIY----------SNRLPKSSPNKEKELALR 316
              + ++  ++ Q L+ K K +E E + + I            +R+ K   N+EK L L 
Sbjct: 240 AMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQL- 298

Query: 317 KNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQ-KQDR 375
           +NA  Q    +   +  + +E  + E Y    E    Y++K +E     L  Q + KQD 
Sbjct: 299 QNALTQK--LEEMLRQREDLEQVRQELY--QEEQAEIYKSKLKEEAEKKLRKQKEMKQDF 354

Query: 376 HGEAG----ILNPIMEREE--------KFVTDEELHVV---KQEVEKLEDEWEREELDKK 420
             +      +L    E EE        KF  D+ + ++   KQ +++LE     E+L ++
Sbjct: 355 EEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEE 414

Query: 421 QKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLK 463
           ++++    ++ E  EW+  + + G             EEERLK
Sbjct: 415 RRQQFLADKQRELEEWQLQQRRQGFINAI-------IEEERLK 450



 Score = 37.0 bits (84), Expect = 0.062
 Identities = 55/264 (20%), Positives = 113/264 (42%), Gaps = 29/264 (10%)

Query: 227 SAELKLDDTERRIKELSKNL--ELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHK 284
           S    L  +ER  K + +N   +L   + +      R +  +  ++N+V +K+  RL   
Sbjct: 3   SKRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRL--- 59

Query: 285 LKEKERELDIKNIYSNRLPKSSPNKE-KELALRKNAACQSDFADLCTKGV------QTME 337
           L+ ++ ELD++      + K+  NK  KEL L++      + A L  + +      Q + 
Sbjct: 60  LQNEQFELDMEEA----IQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVR 115

Query: 338 DFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEE 397
           +   E   L  +    Y NK         D    +Q +  +A I   +ME  ++ + +E 
Sbjct: 116 ENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKR-DAEIAKTMMEEHKRIIKEEN 174

Query: 398 LHVVKQEVEKLEDEWERE-ELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQG 456
               K+   K +   + E +L++++K+K    E+  K +         +Y          
Sbjct: 175 AAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIY---------- 224

Query: 457 EEEERLKREMLLAKLNEIDRELQD 480
            EE++L+++  L K+N + R +++
Sbjct: 225 -EEDQLEKQQKLEKMNAMRRYIEE 247


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 114/479 (23%), Positives = 214/479 (44%), Gaps = 53/479 (11%)

Query: 43   PASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTDLVTK 102
            P S  R  P   + +G ++  +  + SP   P   G      S  L+ E +R       +
Sbjct: 1458 PGSPARDAPAEGSGEG-LNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQ 1516

Query: 103  RILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIF 162
             + SA+  + +EL+ + S L  +LAE+  E  S      + +KA+ + E+A   +   + 
Sbjct: 1517 ELRSAQRER-DELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLS 1575

Query: 163  RHNNEITALKERLRKSQEKERAT-------EKRVKDTESELFRTKFSLQKLKEISEARHL 215
                E+   +E +R+S+ + RAT       E+ ++ TESEL  ++  + K+K  +E +  
Sbjct: 1576 GVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMK-ANETKLE 1634

Query: 216  PERDDLAKKLVSAE---LKLDDTERRIK-ELSKN-LELSTNSFQRQLLAER-----KRAY 265
             ++  L + L ++E   +KL+   R ++ EL ++ L LS    Q Q L +R     ++  
Sbjct: 1635 GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVA 1694

Query: 266  EAHDENKVLQKEVQRL---YHKLKEKEREL-DIKNIYSNRLPKSSPN----KEKELALRK 317
            ++  +   LQ  V+RL     K++E E  L D     +  L +SS +    ++K L L+K
Sbjct: 1695 DSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQK 1754

Query: 318  N-AACQSD---FADLCTKGVQTMEDFKPEE-------YPLTPETIMCYENKWEEPGHLTL 366
               AC+ D     +      Q + + + +          L  E       + E  G L  
Sbjct: 1755 ALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQ 1814

Query: 367  DLQSQKQDRHGEAGILNPIME-REEKFVTDEELHVVKQEVEKLEDEWEREELD--KKQKE 423
              +  +Q + GEA  LN + + ++E+ +  E L  +++ + +LE E    E    + +K+
Sbjct: 1815 LREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKD 1874

Query: 424  KASLLEREEKPEWETGRYQLGMYPIQNMDKLQ-GEEEERLKREMLLAKLN--EIDRELQ 479
            + +L    +K E E  R         + D ++   E+ RL R +  A+L   E  R++Q
Sbjct: 1875 RVALRRTLDKVEREKLR--------SHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQ 1925



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 109/498 (21%), Positives = 193/498 (38%), Gaps = 56/498 (11%)

Query: 46   VRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNR--EPLRKDTDLVTKR 103
            +R++  K Q +  ++  Q  R    +    + G RV    +  +R  E L     ++ K 
Sbjct: 622  LRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKE 681

Query: 104  ILSAR------LLKINELQNEVSELQVKL--AELLKENKSLKRLQYRQEKALNKFEDAEN 155
            ++  R       L+ + LQ E +E+   L  AE  +    L   + R E+A    +D+ +
Sbjct: 682  LVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEA--SLQDSLS 739

Query: 156  EISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHL 215
            ++S L      +   L   + + +E++ A + R +  E E    +   ++L+E+   + +
Sbjct: 740  KLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEV 799

Query: 216  PERDDLAKKLVSAELKLDDTERRIKELS---KNLELSTNSFQRQLLAERKRAYEAHDENK 272
              R  L   L  AE   +  E+++  L      L+       RQL    +   +A  E  
Sbjct: 800  A-RQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE-- 856

Query: 273  VLQKEVQRLYHKLKEKER------ELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFA 326
              Q++V+ L    +EKE        L ++ + + R  ++   +   L L K A   S F 
Sbjct: 857  -AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLF- 914

Query: 327  DLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGE-AGILNPI 385
                            E       +     + E  G   L     K+   GE AG+   I
Sbjct: 915  ----------------EVQRQLAQLEARREQLEAEGQALL---LAKETLTGELAGLRQQI 955

Query: 386  MEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGM 445
            +  +EK   D+EL   K    + E +    E     +E    L+RE++  W     +L  
Sbjct: 956  IATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWR----ELEA 1011

Query: 446  YPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERS 505
               Q   +LQ E+EE L R  L A+  E+  E+   +  +   L L    + +  S + S
Sbjct: 1012 ERAQLQSQLQREQEELLAR--LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKES 1069

Query: 506  PKTYRFSESSERLFNGHH 523
             KT      SE+L    H
Sbjct: 1070 EKT----ALSEKLMGTRH 1083



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 57/220 (25%), Positives = 105/220 (47%), Gaps = 19/220 (8%)

Query: 89   NREPLRKDTDLVTKRILSARLL------KINELQNEVSELQVKLAELLKENKSLKR-LQY 141
            +R+ L++  D   + +  AR        ++  L+ EV++L+++  E   + + L+  L+ 
Sbjct: 1762 DRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQ 1821

Query: 142  RQE---KALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFR 198
            RQE    ALN  +  ++E   L  R  +   AL +   + +E ER+  +  KD  + L R
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA-LRR 1880

Query: 199  T--KFSLQKLKEISEARHLP-ERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQR 255
            T  K   +KL+   +   L  E+  L + L  AEL+L + +R+I++L   + +   S   
Sbjct: 1881 TLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSP 1940

Query: 256  QLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIK 295
              L       +A  +   LQ+EV+RL     + ER L+ +
Sbjct: 1941 AQLE-----VDAQQQQLELQQEVERLRSAQAQTERTLEAR 1975



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 91/421 (21%), Positives = 161/421 (38%), Gaps = 56/421 (13%)

Query: 95  KDTDLVTKRILSARLLKINELQNEVSELQV---KLAELLKENKSLKRLQYRQEKALNKFE 151
           +D     +R+ SA  L   E  N    LQV   +  EL +E + L+  Q    +  ++ E
Sbjct: 585 EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE 644

Query: 152 DAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISE 211
           + + +  Q   R   E+     +L + + K     K + +    L R       L+    
Sbjct: 645 EEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQ---- 700

Query: 212 ARHLPERDDLAKKLVSA-----ELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYE 266
                E+ ++A+ L  A     EL+L  T+ R +E S    LS  S   + LA+ K    
Sbjct: 701 ----AEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKL--- 753

Query: 267 AHDENKV---LQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQS 323
             D N++   L++E   L  + ++ E+E  +      RL        +EL L +  A Q 
Sbjct: 754 --DLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERL--------EELRLEQEVARQG 803

Query: 324 DFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLT---LDLQSQKQDRHGEAG 380
               L     Q  E  + +   L  E     E   +    L+    +L+  +++   +  
Sbjct: 804 LEGSL-RVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVE 862

Query: 381 ILNPIMEREEKFVTDE-----ELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPE 435
            L      +E    +      +L   ++E   L +E  R  L+K+  E +    + +  +
Sbjct: 863 ALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ 922

Query: 436 WETGRYQL---GMYPIQNMDKLQGE------------EEERLKREMLLAKLNEIDRELQD 480
            E  R QL   G   +   + L GE            E+  L +E++  KL + +RE Q 
Sbjct: 923 LEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQA 982

Query: 481 S 481
           S
Sbjct: 983 S 983



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 76/334 (22%), Positives = 146/334 (43%), Gaps = 50/334 (14%)

Query: 102  KRILSARLLKINELQNEVSELQVKLAELLKENKSLKR-LQYRQEKALNKFEDAENEISQL 160
            ++ LS +  +   L  ++   +  LA +  E +  KR  Q RQE+  +      +E+  L
Sbjct: 1061 QQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL 1120

Query: 161  IFRHNNEITALKERLRKSQEKERATEKRVKDT---ESELFRTKFSLQKLKEISEARHLPE 217
              +      A  + +R+ QE+ R   K+ +D+   E+E  RT+  L +            
Sbjct: 1121 RAQREEAAAAHAQEVRRLQEQARDLGKQ-RDSCLREAEELRTQLRLLE----------DA 1169

Query: 218  RDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAY-EAHDENKVLQK 276
            RD L ++L+ A       +R+++E  +  E+     QRQ   E +R+  E   E + L++
Sbjct: 1170 RDGLRRELLEA-------QRKLRESQEGREV-----QRQEAGELRRSLGEGAKEREALRR 1217

Query: 277  EVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNA--ACQSDFADLCTKGVQ 334
              + L   +K+ E E          L  ++ +KE++LAL + A  A   +  +L T G+Q
Sbjct: 1218 SNEELRSAVKKAESE-------RISLKLANEDKEQKLALLEEARTAVGKEAGELRT-GLQ 1269

Query: 335  TME-----------DFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILN 383
             +E           + + +   L  E         E  G L L  +++K+ R    G+  
Sbjct: 1270 EVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQ 1329

Query: 384  PIMEREEKF-VTDEELHVVKQEVEKLEDEWEREE 416
             +++ E    V  +EL V ++++++ E E+   E
Sbjct: 1330 RLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRE 1363



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 43/201 (21%), Positives = 93/201 (46%), Gaps = 17/201 (8%)

Query: 90  REPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNK 149
           R+ L    + V++R+  A  L+  EL+ +     V+ +  L+     ++  YR++  L  
Sbjct: 104 RDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRK--LQA 161

Query: 150 FEDAENEISQLIFRHNNEITALKERLRKSQEK--ERATE---KRVKDTESELFRTKFSLQ 204
           +++ +   +QL+ R   +I   K+R  + +++  ER+ E   +R++DTE         ++
Sbjct: 162 YQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIR 221

Query: 205 KLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQ--RQLLAERK 262
             +E   +  L + + + ++      +LD      + LS+++   TN +   R+ L  R+
Sbjct: 222 LEEEQQRSASLAQVNAMLRE------QLDQAGSANQALSEDIRKVTNDWTRCRKELEHRE 275

Query: 263 RAYEAHDE--NKVLQKEVQRL 281
            A+   +E  N     E  RL
Sbjct: 276 AAWRREEESFNAYFSNEHSRL 296



 Score = 34.3 bits (77), Expect = 0.40
 Identities = 69/332 (20%), Positives = 133/332 (40%), Gaps = 34/332 (10%)

Query: 157 ISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEIS------ 210
           I   + +   ++  ++ R   SQ+      K++ D+ESE    +  LQ+L++ +      
Sbjct: 524 IHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQA 583

Query: 211 --EARHLPERDDLAKKLVSAEL-----KLDDTERRIKELSKNLELSTNSFQRQLLAERKR 263
             +A+   +R   A +L+S E       L   +++ +EL +  E    + Q +L  +R R
Sbjct: 584 HEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQERE-KLQAAQEELRRQRDR 642

Query: 264 AYE----AHDENKVLQKEVQRLYHKLKEKE--RELDIKNIYSNRLPKSSPNKEKELALRK 317
             E    A  +   +++E++R + +L++ E  R +  K +   R   S    ++++   +
Sbjct: 643 LEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAE 702

Query: 318 NAACQSDFADLCTKGVQ-------TMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQS 370
            A    + A+  TK          +M   + EE  L  +++       E      LDL  
Sbjct: 703 KA----EVAEALTKAEAGRVELELSMTKLRAEEASL-QDSLSKLSALNESLAQDKLDLNR 757

Query: 371 QKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQK--EKASLL 428
                  E   L     + E+  T       + E  +LE E  R+ L+   +  E+A   
Sbjct: 758 LVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA 817

Query: 429 EREEKPEWETGRYQLGMYPIQNMDKLQGEEEE 460
             ++ P     R QL     Q   +L G E+E
Sbjct: 818 LEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849



 Score = 29.6 bits (65), Expect = 9.9
 Identities = 32/137 (23%), Positives = 60/137 (43%), Gaps = 19/137 (13%)

Query: 88   LNREPLRKDTDLVT--------KRILSARLLKINELQNEVSELQVKLAELLKENKSLKRL 139
            + RE LR   D V          R L+   L++ E Q ++ +L+ ++  +L+++ S  +L
Sbjct: 1885 VEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVV-VLEQSHSPAQL 1943

Query: 140  QYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRT 199
            +           DA+ +  +L        +A  +  R  + +ERA  +RV+  E ++   
Sbjct: 1944 EV----------DAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTL 1993

Query: 200  KFSLQKLKEISEARHLP 216
            K  LQ+    S A   P
Sbjct: 1994 KGQLQQELRRSSAPFSP 2010


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 129/613 (21%), Positives = 259/613 (42%), Gaps = 82/613 (13%)

Query: 39   VSSSPASVRRKNPKRQTSDGQVHHQAPRKPSPKGLPNRKGVRVGFRSQSLNREPLRKDTD 98
            VSS+ + + +K+ +      Q++ Q     S K + +   V      Q L    L+    
Sbjct: 1325 VSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQ---- 1380

Query: 99   LVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEIS 158
                    A L  + ELQ ++ ELQ KL    +E+ S    Q      L++ E A  +I 
Sbjct: 1381 -------IAGLEHLRELQPKLDELQ-KLISKKEEDVSYLSGQ------LSEKEAALTKIQ 1426

Query: 159  QLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPER 218
              I    + I AL  +L + Q KE   ++R+K  + EL   K   QK +EI E      +
Sbjct: 1427 TEIIEQEDLIKALHTQL-EMQAKEH--DERIKQLQVELCEMK---QKPEEIGEESR--AK 1478

Query: 219  DDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQR--QLLAERKRAYEAHDENK---- 272
              + +KL +A +   +  +  K L + L L+  + +R  + LA+ +    A ++ K    
Sbjct: 1479 QQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVL 1538

Query: 273  ----VLQKEVQRLYHKLKEK--ERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFA 326
                +LQ+E  +L  ++     E +    +  S +L      ++KE  +++  + +S   
Sbjct: 1539 GRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKI 1598

Query: 327  DLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIM 386
               T+  +  ++ + +EY +  ++     N+ E   H+   ++ +KQ+ +G+        
Sbjct: 1599 AESTEWQEKHKELQ-KEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLR-----S 1652

Query: 387  EREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQK-----EKASLLEREEKPEWETGRY 441
                K  T+++L   +QE+E+++++  +    K+QK     E+   L  E  P  +T + 
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKE 1712

Query: 442  QLGMYPIQNMDKLQGEEEERLKRE---------MLLAKLNEIDRELQDSRNLKYPVLPLL 492
               M  + + +    EE ER+K E          L+++ + +  E+QD   LK+ +   +
Sbjct: 1713 --CMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQD---LKHQIEGNV 1767

Query: 493  PDFESKLHSPERSPKTYRFSESSERLFNGHHLQDISFSTPK----GEGQNSGNVRSPASP 548
               ++ L + E+       +E   +   G   +  S S        E   S    +PA  
Sbjct: 1768 SK-QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVS 1826

Query: 549  NEFA----FGSYVPSFAKTSERSNPFSQK-------SSFLDFQRNSM--EKLSKDG-VDL 594
             +F+      +Y+    +  ER     ++       S  L+ ++N++  +  +KDG + +
Sbjct: 1827 KDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKM 1886

Query: 595  ITRKEKKANLMEQ 607
            +  +  K NL+ Q
Sbjct: 1887 LQEEVTKMNLLNQ 1899



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 86/418 (20%), Positives = 175/418 (41%), Gaps = 48/418 (11%)

Query: 114  ELQNEVSELQV-KLAELLKENKSLKRLQYRQEKALNKFEDAENE---ISQLIFRHNNEIT 169
            +L  E+  L+  K+AE  +  +  K LQ   E  L  +E+  NE   I  ++     E  
Sbjct: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQ 1644

Query: 170  ALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAE 229
             L  +LR ++  ++ TEK++++ E E+   K  ++K  + S+ + + E ++   +L +  
Sbjct: 1645 ELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK-SKQQKILELEEENDRLRAEV 1703

Query: 230  LKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEA--------HDENKVLQKEVQRL 281
                DT +   E      LS+N+  ++ L   K  YE           E   L +EVQ L
Sbjct: 1704 HPAGDTAKECMETL----LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL 1759

Query: 282  YHKLK---EKERELDIKNIYSNRL------PKSSPNKEKE---LALRKNAACQSDFADLC 329
             H+++    K+  L+    + N+        +S P + +E   L++     C        
Sbjct: 1760 KHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAK 1819

Query: 330  TKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMERE 389
            +      +DF       + + I  Y  + ++       L+ +KQ         +  +E E
Sbjct: 1820 SANPAVSKDFS------SHDEINNYLQQIDQLKERIAGLEEEKQKNKE----FSQTLENE 1869

Query: 390  EKFV------TDEELHVVKQEVEKLE--DEWEREELDKKQKEKASLLEREEKPEWETGRY 441
            +  +       D EL ++++EV K+   ++  +EEL +  K K +  E ++  E E    
Sbjct: 1870 KNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLE-ERLMN 1928

Query: 442  QLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKL 499
            QL        +  Q   + ++K E+L +++  + + + +    K  ++      ES++
Sbjct: 1929 QLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEI 1986



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 78/425 (18%), Positives = 178/425 (41%), Gaps = 54/425 (12%)

Query: 86   QSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEK 145
            Q   +EP  K      + +L  +  ++ +LQ +    Q K++ L    +++K L++ Q +
Sbjct: 1995 QGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISAL---ERTVKALEFVQTE 2051

Query: 146  ALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQK 205
            +    E  +  ++Q +           E  +K+Q +  + +  + DT+SE  R      K
Sbjct: 2052 SQKDLEITKENLAQAV-----------EHRKKAQAELASFKVLLDDTQSEAARVLADNLK 2100

Query: 206  LKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAY 265
            LK+  ++     +  + +K    E +L+  E +  +  KN++   ++ +R+ +   +   
Sbjct: 2101 LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIG 2160

Query: 266  EAHDENKVLQKEVQRLYHKL------------------KEKERELDIKNIYSNRLPKSSP 307
            E         KEVQ+L   L                   +++R +D    +  +   +  
Sbjct: 2161 EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQ 2220

Query: 308  NKEKELALRKNAACQSDFADLCT--KGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLT 365
            +KE+E+ L++         D C+  K          EE  +    +   +  WE      
Sbjct: 2221 SKEEEIRLKE---------DNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271

Query: 366  LDLQSQKQDR-HGE-AGILNPIMEREEKFVTDE-ELHVVKQEVEKLEDEWE--REELDKK 420
            + LQ +  D   GE   +L+ + E    + + + EL  ++ E++ L+D+       L+K 
Sbjct: 2272 VQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC 2331

Query: 421  QKEKASL--LEREEKPEWETGR--YQLGMYPIQNMDKLQG--EEEERLKREMLLAKLNEI 474
            +++K +L  + R+++ + +  +  Y+     +Q   +L     EE  +K + +++ L+  
Sbjct: 2332 KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGK 2391

Query: 475  DRELQ 479
            +  +Q
Sbjct: 2392 EEAIQ 2396



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 106/483 (21%), Positives = 195/483 (40%), Gaps = 117/483 (24%)

Query: 86   QSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKR----LQY 141
            + LN+    KD+    K++L  +L +  EL+N+ ++L+ KL E  + N+ L+R    LQ 
Sbjct: 2538 EDLNQVITIKDSQ--QKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQE 2595

Query: 142  RQEKALNKFEDAENEISQLIFRHNNEITALKE---------RLRKSQEKER-------AT 185
             ++    + E  +  ISQL      ++TAL+E         +L+  +E+         ++
Sbjct: 2596 EKQDLSKEIESLKVSISQL----TRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS 2651

Query: 186  EKRVKDTESELFRT-KFSLQKLKEI-----SEARHLPERDDLAKKLVSAELKLDDTERRI 239
            +KR+ + E EL    K + +K+ EI      E +HL     + +       + +  E R+
Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRN------ETETAEERV 2705

Query: 240  KELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYS 299
             EL+++L       +++LL   K       ENK L  ++Q     +   +   D  N   
Sbjct: 2706 AELARDLV----EMEQKLLMVTK-------ENKGLTAQIQSFGRSMSSLQNSRDHANEEL 2754

Query: 300  NRLPKSSPNKEKELA-LRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKW 358
            + L +      KELA L++      +   L ++   +M   +        +      +K 
Sbjct: 2755 DELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKD 2814

Query: 359  EEPGHLTLDLQSQKQDRHGEAGILNPIM-----ERE------EKFVTDE----------- 396
            E+     L L SQ +D + +    +  M     ER+      EKF   E           
Sbjct: 2815 EQ----LLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPS 2870

Query: 397  ----ELHVVKQEVEKLEDEWER--EELDKKQKE--------------KASLLE------- 429
                E+  +K+ +  L+++ +R  +EL   Q++              KA L E       
Sbjct: 2871 TSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKA 2930

Query: 430  --------REEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDS 481
                    R+E   W+   +QL       M+K   E  ER  +E  L  +++ D++L   
Sbjct: 2931 FQIMQEELRQENLSWQHELHQL------RMEKSSWEIHERRMKEQYLMAISDKDQQLSHL 2984

Query: 482  RNL 484
            +NL
Sbjct: 2985 QNL 2987



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 72/330 (21%), Positives = 141/330 (42%), Gaps = 37/330 (11%)

Query: 116  QNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITAL---K 172
            Q   ++     AE+    K++  LQ  +++ L + ++ + +  Q+    N EIT L   K
Sbjct: 2863 QRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQI----NQEITELHPLK 2918

Query: 173  ERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELK- 231
             +L++ Q+K +A +   ++   E    +  L +L+    +  + ER    + L++   K 
Sbjct: 2919 AQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKD 2978

Query: 232  -----LDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQR--LYHK 284
                 L +  R ++  S   +     +QRQ   E   + +   +N V + E+ R  L   
Sbjct: 2979 QQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDG-SQNLVYETELLRTQLNDS 3037

Query: 285  LKE-KERELDIKNIYSN--RLPKSSPNKEKEL-----ALRKNAACQSDFADLCT---KGV 333
            LKE  ++EL I+ + SN  +L +       +L     +LR+N     D  + C    K V
Sbjct: 3038 LKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQV 3097

Query: 334  QTME--DFKPEEYPLTPETIMCYENKWE-----EPGHLTLDLQSQKQDRHGEAGILNPIM 386
            Q ++      +  P  P+       K +     EP     + Q Q  +   E   L  ++
Sbjct: 3098 QELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLL 3157

Query: 387  E--REEKFVTDEELHVVKQEVEKLE-DEWE 413
            E  R+++   +  L V ++++ +LE  EW+
Sbjct: 3158 EEERDQRVAAENALSVAEEQIRRLEHSEWD 3187



 Score = 43.1 bits (100), Expect = 9e-04
 Identities = 86/411 (20%), Positives = 168/411 (40%), Gaps = 51/411 (12%)

Query: 96   DTDLVTKRILSARLLK---------INELQNEVSELQVKLAELLKEN-KSLKRLQ--YRQ 143
            +TDL   R L++RL +         I+ L  +   +QV +AEL +++ K +K L+    Q
Sbjct: 2360 ETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQ 2419

Query: 144  EKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTES---ELFRTK 200
            E+  N   + EN+  + + + N  +  LK   +++ +++   +  VK   S   +  R  
Sbjct: 2420 EEEENIVLEEENK--KAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV 2477

Query: 201  FSLQKLKEISEARHLP---ERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQL 257
               Q+L+E    RHL    E+D L ++  +   KL +  R ++    +L         +L
Sbjct: 2478 GDYQQLEE----RHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL 2533

Query: 258  L--------------AERKRAYEAH-DENKVLQKEVQRLYHKLKEKERELDIKNIYSNRL 302
            +              +++K+  E    +NK L+ +  +L  KLKE E   +      N L
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593

Query: 303  PKSSPNKEKELALRKNAACQ-----SDFADLCTKGVQTME-DFKPEEYPLTPETIMCYEN 356
             +   +  KE+   K +  Q     +   +  T G+   +   K EE          + +
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEE---VHRLSALFSS 2650

Query: 357  KWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREE 416
              +    L  +L   +++   + G +   +++E K +   +  +++ E E  E+      
Sbjct: 2651 SQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHL-HHDAGIMRNETETAEERVAELA 2709

Query: 417  LDKKQKEKASLLEREEKPEWETGRYQLG--MYPIQNMDKLQGEEEERLKRE 465
             D  + E+  L+  +E           G  M  +QN      EE + LKR+
Sbjct: 2710 RDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRK 2760



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 96/495 (19%), Positives = 198/495 (40%), Gaps = 91/495 (18%)

Query: 105  LSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNK----------FEDAE 154
            LS  LL++ E Q E++ L+++L     E    + L  ++ K +            F +  
Sbjct: 559  LSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDT 618

Query: 155  NEISQLIFRHNNEITALKERLRKSQEKERATEK-RVKDTESELFRTKF----SLQKLKEI 209
             +   L+    + + A+++    ++ + R +E+  + D   EL  TK     SL  + +I
Sbjct: 619  GQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDI 678

Query: 210  SEARHLPERDDLAKKLVSAEL------------------KLDDTERRIKELSKNLELSTN 251
             +  H  E + L  +++  EL                  ++ +  + I+E  KN + +++
Sbjct: 679  GQC-HQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSS 737

Query: 252  SF------QRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERE-------------L 292
            +F      + QLL++ K      +    L+ +V++L   L E ER+             L
Sbjct: 738  AFTALSEERDQLLSQVKELSMVTE----LRAQVKQLEMNLAEAERQRRLDYESQTAHDNL 793

Query: 293  DIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCT--KGVQTMEDFKPEEYPLTPET 350
              + I+S  +   S + + E+   +    Q  F++  T  + +Q+    K  E     E 
Sbjct: 794  LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAER 853

Query: 351  IMCYENKWEEPGHLTL--DLQSQKQD-----RHGEAGILNPIMEREEKFVTDEELHVVKQ 403
            +    +K EE        +L+  K D     +  +   L   +E +++ VT+    + ++
Sbjct: 854  VRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEK 913

Query: 404  EVEKLEDEWEREELDKKQKEKASLLEREEKPEWE-------------------TGRYQLG 444
             V+  E+++      K  KE+ +LL R E+ + E                   +   Q+ 
Sbjct: 914  MVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQIS 973

Query: 445  MYPIQNMDKLQGEEEERLKREMLLAKLN------EIDRELQDSRNLKYPVLPLLPDFESK 498
               +Q+   L  +E E+ KR++  A +N       + R  ++  NLK      +P  E++
Sbjct: 974  KEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETE 1033

Query: 499  LHSPERSPKTYRFSE 513
                E   +   +SE
Sbjct: 1034 RGEVEEDKENKEYSE 1048



 Score = 38.5 bits (88), Expect = 0.021
 Identities = 56/309 (18%), Positives = 131/309 (42%), Gaps = 18/309 (5%)

Query: 111  KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
            +++++Q + SE    +  L  + ++ +       + +        E+SQ + +   EIT 
Sbjct: 818  ELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITK 877

Query: 171  LKERLRKSQEKERATEKRVKDTESELFRTKFSL-QKLKEISEARHLPERDDLAKKLVSAE 229
            + + L + +      ++ +++ + ++    FS+ +K+ +++E +       +  K +  +
Sbjct: 878  MDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKF---SLGVEIKTLKEQ 934

Query: 230  LKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKE 289
            L L       K+     +   +S  +Q   E   A +   E   LQ E   L  + ++++
Sbjct: 935  LNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEE--LQHEFDLLKKENEQRK 992

Query: 290  RELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPE 349
            R+L    I    L +     E+ELA  K+ + + +     T+  +  ED + +EY     
Sbjct: 993  RKLQAALINRKELLQRVSRLEEELANLKDES-KKEIPLSETERGEVEEDKENKEYSEKCV 1051

Query: 350  TIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELH-VVKQEVEKL 408
            T  C E          +++  ++     E  + +   + EEK   +E+   +VKQ  + L
Sbjct: 1052 TSKCQE----------IEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTL 1101

Query: 409  EDEWEREEL 417
            +D+  + +L
Sbjct: 1102 QDKTNQIDL 1110



 Score = 36.6 bits (83), Expect = 0.081
 Identities = 63/311 (20%), Positives = 123/311 (39%), Gaps = 59/311 (18%)

Query: 179 QEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERR 238
           QE+    E+ V + +  + +    LQ+  E  +       + + K  + A+ KL    + 
Sbjct: 51  QERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKY 110

Query: 239 IKELSKN--LELSTNSFQRQLLAERKRAYEAHDENKVLQK-EVQRLYHKLKEKERELDIK 295
           I+E+       L T     + L++       HD++   ++ E++++ HKL+EKE      
Sbjct: 111 IEEMKAQGGTVLPTEPQSEEQLSK-------HDKSSTEEEMEIEKIKHKLQEKE------ 157

Query: 296 NIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYE 355
                           EL     A      A+   +    ME+F            +  +
Sbjct: 158 ----------------ELISTLQAQLTQAQAEQPAQSSTEMEEF------------VMMK 189

Query: 356 NKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWERE 415
            + +E       LQ+Q      E      + E++ +F T   LH  + E+ +L  +    
Sbjct: 190 QQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLH--EDELLQLVTQ---A 244

Query: 416 ELDKKQKEKASLLER--EEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLA-KLN 472
           +++ + ++K  +L+R  EE  E   GR Q+       +D LQ E     +R  +L+ +L 
Sbjct: 245 DVETEMQQKLRVLQRKLEEHEESLVGRAQV-------VDLLQQELTAAEQRNQILSQQLQ 297

Query: 473 EIDRELQDSRN 483
           +++ E    RN
Sbjct: 298 QMEAEHNTLRN 308


>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
           theta, 150/170kDa [Homo sapiens]
          Length = 1382

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 94/391 (24%), Positives = 172/391 (43%), Gaps = 50/391 (12%)

Query: 114 ELQNEVSELQVKLAELLKENKSLKRLQYRQEK---ALNKFEDAENEISQLIFRHNNEITA 170
           +++N+++ +   LA+ L+  K    LQ ++E+   A+  +     +  Q I      I  
Sbjct: 518 QIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEE 577

Query: 171 LKERL--------RKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLA 222
            KERL        ++  E+  A  ++V+  E E  R     Q+ KE  + R L E + + 
Sbjct: 578 RKERLESLNIQREKEELEQREAELQKVRKAEEERLR-----QEAKEREKERILQEHEQIK 632

Query: 223 KKLVSAELKLDDTERRIKELSKNLELSTNSFQR---QLLAERKRAYEAHDENKVLQKEVQ 279
           KK V   L          E  K  EL   +F+    + L E    +    + + L+KE +
Sbjct: 633 KKTVRERL----------EQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKK 682

Query: 280 RLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDF 339
            L  +LK +E+++D    Y  R  +      +E+ L K+A  +    D+     Q  E+ 
Sbjct: 683 ELQERLKNQEKKID----YFERAKRL-----EEIPLIKSAYEEQRIKDMDLWEQQ--EEE 731

Query: 340 KPEEYPLTPETIMCYENKW----EEPGHLTLDLQSQKQDRHGEAGILNPIMER--EEKFV 393
           +     L  E  + ++N+     E+     + L++ +Q  + E   L    ER  EE+  
Sbjct: 732 RITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEK--LKQFEERLAEERHN 789

Query: 394 TDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDK 453
             EE    ++E  ++    E+EE ++++ E+  L EREE+   E  + +  +   Q   K
Sbjct: 790 RLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVK 849

Query: 454 LQGEEEERLKREMLLAKLNEIDRELQDSRNL 484
            + EE ER KR+  L ++ E +R  ++ R L
Sbjct: 850 -KLEEVERKKRQREL-EIEERERRREEERRL 878


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 93/401 (23%), Positives = 172/401 (42%), Gaps = 62/401 (15%)

Query: 96   DTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFE-DAE 154
            +T L T+++  +   K+ +   E   + +KL   LKE +   +   +  K LN  E   +
Sbjct: 1127 ETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLK 1186

Query: 155  NEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARH 214
             EI+QL     N +  +K  L+  +E+E    +  +  + EL  +    Q LK   + + 
Sbjct: 1187 EEITQL----TNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKE 1242

Query: 215  LPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVL 274
                +D A      + KL D +++IK++ K + +                    DE+K+L
Sbjct: 1243 ----EDYA----DLKEKLTDAKKQIKQVQKEVSVM------------------RDEDKLL 1276

Query: 275  QKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRK-NAACQSDFADLCTKGV 333
            + ++  L  K  +  +ELD+K     +L +   N++ E A+++   AC+    ++  K +
Sbjct: 1277 RIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKD--LNVKEKII 1334

Query: 334  QTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFV 393
            + M     E+     E     E K EE   L  +L+  K+  +      N    +E +  
Sbjct: 1335 EDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENN 1394

Query: 394  TDEELHVVKQEVEKLEDEWEREE----LDKKQ--KEKASLLEREEKPEWETGRYQLGMYP 447
            TD     V  ++  L+DE +  E     D+K+  +EK  L+ + ++ E            
Sbjct: 1395 TD-----VLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAE-----------N 1438

Query: 448  IQNMD-KLQGEEEERL-----KREMLLAKLNEIDRELQDSR 482
            I+N + K   E+ ER      + E+L A+L E D +LQ  R
Sbjct: 1439 IRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWR 1479



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 82/377 (21%), Positives = 161/377 (42%), Gaps = 60/377 (15%)

Query: 111  KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
            +I EL+ ++ +LQ ++     EN  LK  +++ +  L K  + E  I QL      +   
Sbjct: 1037 QIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLK--EKETLIQQLKEELQEKNVT 1094

Query: 171  LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAEL 230
            L  +++   E +RA  +  +         K  +++L+ I E + +       +   SA+L
Sbjct: 1095 LDVQIQHVVEGKRALSELTQGVTC----YKAKIKELETILETQKV-------ECSHSAKL 1143

Query: 231  KLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKER 290
            + D  E+  + +   LE +   FQ  L    K   + + +   L++E+ +L + L++ + 
Sbjct: 1144 EQDILEK--ESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKH 1201

Query: 291  ELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPET 350
             L +K        +    K KE     +A  Q+  ADL  K     ED+   +  LT   
Sbjct: 1202 LLQLKE-EEEETNRQETEKLKEELSASSARTQNLKADLQRK----EEDYADLKEKLT--- 1253

Query: 351  IMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLED 410
                            D + Q +    E  ++     R+E    D+ L +   E+EK ++
Sbjct: 1254 ----------------DAKKQIKQVQKEVSVM-----RDE----DKLLRIKINELEKKKN 1288

Query: 411  EWEREELDKKQKEKASLLER--EEKPEWETGRYQLGMYPIQNMDK--------LQGEEEE 460
            +   +ELD KQ+    L E+   +K E    +Y+     +   +K        L+ +E+ 
Sbjct: 1289 QCS-QELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQT 1347

Query: 461  RLKREMLL-AKLNEIDR 476
            +++++ +L AKL E++R
Sbjct: 1348 QVEQDQVLEAKLEEVER 1364



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 94/414 (22%), Positives = 169/414 (40%), Gaps = 58/414 (14%)

Query: 105  LSARLLKI-NELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFR 163
            L A LL I NEL+NE  E     AEL   NK +   Q     +  K      E+ Q+   
Sbjct: 847  LRAFLLTIENELKNEKEEK----AEL---NKQIVHFQQELSLSEKKNLTLSKEVQQIQSN 899

Query: 164  HNNEITALKERLRKSQEKERATEKRVKDTES------------ELFRTKFSLQKLKEISE 211
            ++  I  L  +  K+QE+E    K   + E+            +L  TK  + +L+ +  
Sbjct: 900  YDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTK--IDELRTLDS 957

Query: 212  ARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAH--- 268
               +   D L  + +S   + D+      +L  N  L +   +   + E  R    H   
Sbjct: 958  VSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSI 1017

Query: 269  ----DENKVLQKEVQRLYHKLKEKEREL-----DIKNI--YSNRLPKSSPNKEKELALRK 317
                +E K + K   +  H+++E E+++     ++K     +NRL +     + +L   K
Sbjct: 1018 EAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEK 1077

Query: 318  NAACQSDFADLCTKGV------QTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQ 371
                Q    +L  K V      Q + + K     LT + + CY+ K +E   L   L++Q
Sbjct: 1078 ETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELT-QGVTCYKAKIKE---LETILETQ 1133

Query: 372  KQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLERE 431
            K +    A +   I+E+E           +  ++E+   E++ E L    K    L  +E
Sbjct: 1134 KVECSHSAKLEQDILEKES----------IILKLERNLKEFQ-EHLQDSVKNTKDLNVKE 1182

Query: 432  EKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLK 485
             K + E  +    +  ++++ +L+ EEEE  ++E    K  E+      ++NLK
Sbjct: 1183 LKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLK-EELSASSARTQNLK 1235



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 55/241 (22%), Positives = 106/241 (43%), Gaps = 26/241 (10%)

Query: 90  REPLRKD---TDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKA 146
           RE   KD   T + T+   +   LK N+++ E+++ +    EL+K  + LK+ +   +  
Sbjct: 652 REEAAKDICATKVETEEATACLELKFNQIKAELAKTK---GELIKTKEELKKRENESDSL 708

Query: 147 LNKFEDAENEI---SQLIFRHNNEITALKERLRKSQEKERATEKRVK-----DTESELFR 198
           + + E +  +I   +Q I    N I   ++ + + Q  +   E   K     DT S +  
Sbjct: 709 IQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIIN 768

Query: 199 TKFSLQKLKEI---SEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQR 255
            K    +  E+   S+++   ER    K++   EL+ D+   +      ++ +S+   + 
Sbjct: 769 NKLICNETVEVPKDSKSKICSER----KRVNENELQQDEPPAK----KGSIHVSSAITED 820

Query: 256 QLLAERKRAYEAHDEN-KVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELA 314
           Q  +E  R   A  E+ +VLQ+  + L   L   E EL  +      L K   + ++EL+
Sbjct: 821 QKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELS 880

Query: 315 L 315
           L
Sbjct: 881 L 881



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 57/266 (21%), Positives = 98/266 (36%), Gaps = 77/266 (28%)

Query: 131 KENKSLKRLQYRQEKALNKFEDAEN---------EISQLIFRHNNEITALK--------- 172
           +++K  + + +R+ K  + F+   N          ISQ    ++  +  LK         
Sbjct: 421 EKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVC 480

Query: 173 --ERLRKSQEKERATEKRVKD------TESELFRTKFSL----QKLKEISEARHLPERDD 220
             + L  SQEK     K  +D      + S++   K +       L+++ E   L E  +
Sbjct: 481 VPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELE 540

Query: 221 LAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQR 280
            A++  + E KL D     ++L K LE               +A+ +H+E + L   ++ 
Sbjct: 541 NAEETQNVETKLLD-----EDLDKTLE-------------ENKAFISHEEKRKLLDLIED 582

Query: 281 LYHKL----KEK--------------------ERELDIKNIYSNRLPKSSPNKEKELALR 316
           L  KL    KEK                    +RE D K            N E+ LA+ 
Sbjct: 583 LKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIF 642

Query: 317 KNAACQSD-----FADLCTKGVQTME 337
           K+   + D       D+C   V+T E
Sbjct: 643 KDLVGKCDTREEAAKDICATKVETEE 668


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 78/365 (21%), Positives = 163/365 (44%), Gaps = 68/365 (18%)

Query: 110 LKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEIT 169
           ++ + L  E+  +  KL   ++EN+    L  +QE+ + + E+   E  + +     +I 
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321

Query: 170 ALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAE 229
             +E++ + +EK    E+++++ E +++R +   +K++E  E            K+   E
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQE---EKIREQEE------------KIREQE 366

Query: 230 LKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKE 289
            K+   E +I+E  + ++       RQ    R++  +  ++    +K+++    K++E+E
Sbjct: 367 EKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQE 426

Query: 290 RELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPE 349
            E+  +      L +   ++E++L                    + +E+   EE      
Sbjct: 427 EEMWRQEEKIRELEEMMQDQEEKL--------------------REVEEKMQEE------ 460

Query: 350 TIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLE 409
                E K +E        Q +K  R  E      I E+EEK    E+L  +KQE    E
Sbjct: 461 -----EEKMQE--------QEEKIQRQEE-----KIQEQEEKTWRQEKL--LKQE----E 496

Query: 410 DEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMD-KLQGEEEERLKREMLL 468
             WE+EE   +Q+EK  + E+EEK + +  + Q     ++  + +L  +EE+  ++E+ L
Sbjct: 497 KIWEQEEKMWRQEEK--MWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRL 554

Query: 469 AKLNE 473
            +L E
Sbjct: 555 QELEE 559



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 53/227 (23%), Positives = 110/227 (48%), Gaps = 20/227 (8%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           KI E + E+   + K+ E  +E K  +++ +RQEK + + ++   E  + ++R   +I  
Sbjct: 382 KIQEQEEEMWRQEEKIRE--QEEKRQEKM-WRQEKKMREQDEKIREQEEEMWRQEEKIRE 438

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE-ISEARHLPERDD----LAKKL 225
           L+E ++  +EK R  E+++++ E ++   +  +Q+ +E I E      R +      +K+
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKI 498

Query: 226 VSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEA---HDENKVLQKEV--QR 280
              E K+   E ++ E  + ++      QRQ   E+ R  E      E K+ ++EV  Q 
Sbjct: 499 WEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ--EEKMREQEVRLWQQEEKMQEQEVRLQE 556

Query: 281 LYHKLKEKERELDI-----KNIYSNRLPKSSPNKEKELALRKNAACQ 322
           L  +L +  ++ ++     +   S RLP  +P  + EL  ++  + Q
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQ 603



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 102/481 (21%), Positives = 199/481 (41%), Gaps = 33/481 (6%)

Query: 75  NRKGVRVGFRSQSLNREPLRKDTDLVTKRILSAR-LLKINELQNEVSELQVKLAELLKEN 133
           N   V+  F+ +   +E + +      KR++  +  L++ E+  +       L E L  +
Sbjct: 127 NSDEVKSSFKKR---QEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFD 183

Query: 134 KSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTE 193
            +++   Y ++  L K  DA    S  ++R+      LKE+  + QEK R  E    + +
Sbjct: 184 HAVRMGTYIEK--LTKERDAP---SLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQ 238

Query: 194 SELFRTKFSLQKLKEISEARHLP-ERDDLAKKL--VSAELKLDDTERRIKELSKNLELST 250
             +   K  L++ + +   + L  E D L K+L  VSA+L+    E  +  L    +   
Sbjct: 239 LNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEK 298

Query: 251 NSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKE 310
              Q + + E++       E K+ ++E +    + K  E+E  I+        +    +E
Sbjct: 299 MWRQEEKIQEQEEKM-CEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIRE 357

Query: 311 KELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQS 370
           +E  +R+         +   +  + +++ + EE     E I   E K +E     +  Q 
Sbjct: 358 QEEKIREQEEKMWRQEEKIREQDEKIQE-QEEEMWRQEEKIREQEEKRQEK----MWRQE 412

Query: 371 QKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLER 430
           +K     E      I E+EE+    EE     +E+ + ++E  RE  +K Q+E+  + E+
Sbjct: 413 KKMREQDEK-----IREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQ 467

Query: 431 EEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLL----AKLNEIDRELQDSRNLKY 486
           EEK + +  + Q         +KL  +EE+  ++E  +     K+ E + ++Q+      
Sbjct: 468 EEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQ 527

Query: 487 PVLPLLPDFESKLHSPER--SPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSGNVRS 544
                + + E +L   E     +  R  E  ERL       ++      G G+ SG+ R 
Sbjct: 528 RQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELL----GGAGRESGSQRL 583

Query: 545 P 545
           P
Sbjct: 584 P 584


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 78/365 (21%), Positives = 163/365 (44%), Gaps = 68/365 (18%)

Query: 110 LKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEIT 169
           ++ + L  E+  +  KL   ++EN+    L  +QE+ + + E+   E  + +     +I 
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321

Query: 170 ALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAE 229
             +E++ + +EK    E+++++ E +++R +   +K++E  E            K+   E
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQE---EKIREQEE------------KIREQE 366

Query: 230 LKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKE 289
            K+   E +I+E  + ++       RQ    R++  +  ++    +K+++    K++E+E
Sbjct: 367 EKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQE 426

Query: 290 RELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKPEEYPLTPE 349
            E+  +      L +   ++E++L                    + +E+   EE      
Sbjct: 427 EEMWRQEEKIRELEEMMQDQEEKL--------------------REVEEKMQEE------ 460

Query: 350 TIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLE 409
                E K +E        Q +K  R  E      I E+EEK    E+L  +KQE    E
Sbjct: 461 -----EEKMQE--------QEEKIQRQEE-----KIQEQEEKTWRQEKL--LKQE----E 496

Query: 410 DEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMD-KLQGEEEERLKREMLL 468
             WE+EE   +Q+EK  + E+EEK + +  + Q     ++  + +L  +EE+  ++E+ L
Sbjct: 497 KIWEQEEKMWRQEEK--MWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRL 554

Query: 469 AKLNE 473
            +L E
Sbjct: 555 QELEE 559



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 53/227 (23%), Positives = 110/227 (48%), Gaps = 20/227 (8%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           KI E + E+   + K+ E  +E K  +++ +RQEK + + ++   E  + ++R   +I  
Sbjct: 382 KIQEQEEEMWRQEEKIRE--QEEKRQEKM-WRQEKKMREQDEKIREQEEEMWRQEEKIRE 438

Query: 171 LKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE-ISEARHLPERDD----LAKKL 225
           L+E ++  +EK R  E+++++ E ++   +  +Q+ +E I E      R +      +K+
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKI 498

Query: 226 VSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEA---HDENKVLQKEV--QR 280
              E K+   E ++ E  + ++      QRQ   E+ R  E      E K+ ++EV  Q 
Sbjct: 499 WEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQ--EEKMREQEVRLWQQEEKMQEQEVRLQE 556

Query: 281 LYHKLKEKERELDI-----KNIYSNRLPKSSPNKEKELALRKNAACQ 322
           L  +L +  ++ ++     +   S RLP  +P  + EL  ++  + Q
Sbjct: 557 LEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQ 603



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 87/408 (21%), Positives = 168/408 (41%), Gaps = 24/408 (5%)

Query: 147 LNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKL 206
           + K     + +S  ++R+      LKE+  + QEK R  E    + +  +   K  L++ 
Sbjct: 192 IEKLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERA 251

Query: 207 KEISEARHLP-ERDDLAKKL--VSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKR 263
           + +   + L  E D L K+L  VSA+L+    E  +  L    +      Q + + E++ 
Sbjct: 252 QLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEE 311

Query: 264 AYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQS 323
                 E K+ ++E +    + K  E+E  I+        +    +E+E  +R+      
Sbjct: 312 KM-CEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMW 370

Query: 324 DFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILN 383
              +   +  + +++ + EE     E I   E K +E     +  Q +K     E     
Sbjct: 371 RQEEKIREQDEKIQE-QEEEMWRQEEKIREQEEKRQEK----MWRQEKKMREQDEK---- 421

Query: 384 PIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQL 443
            I E+EE+    EE     +E+ + ++E  RE  +K Q+E+  + E+EEK + +  + Q 
Sbjct: 422 -IREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQE 480

Query: 444 GMYPIQNMDKLQGEEEERLKREMLL----AKLNEIDRELQDSRNLKYPVLPLLPDFESKL 499
                   +KL  +EE+  ++E  +     K+ E + ++Q+           + + E +L
Sbjct: 481 QEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRL 540

Query: 500 HSPER--SPKTYRFSESSERLFNGHHLQDISFSTPKGEGQNSGNVRSP 545
              E     +  R  E  ERL       ++      G G+ SG+ R P
Sbjct: 541 WQQEEKMQEQEVRLQELEERLGKLGQKAELL----GGAGRESGSQRLP 584


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
            [Homo sapiens]
          Length = 1388

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 87/420 (20%), Positives = 177/420 (42%), Gaps = 35/420 (8%)

Query: 112  INELQNEVSELQVKLAELLKENKSL-KRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
            IN+LQ  +  L+    E LK  K L  +++  + +   +F D E E S +      ++  
Sbjct: 641  INDLQGRICGLE----EDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKV 696

Query: 171  LKERLRKSQEKERATEKRVKDTES-----ELFRTKFSLQKLKEISEARHLPERD-----D 220
            +++ L + + + +AT+ R+ D        E  +++   +  K++ E R L ++      +
Sbjct: 697  IQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLE 756

Query: 221  LAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVLQKEVQR 280
              K+    +  L  ++++I EL K  ++     +   L   +   +       L+ + Q+
Sbjct: 757  AEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQ 816

Query: 281  LYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFK 340
            + + LK  E++L  +N   N L +   N EK+     NA  + +  D   +  +  +  +
Sbjct: 817  V-NTLKMSEKQLKQEN---NHLMEMKMNLEKQ-----NAELRKERQDADGQMKELQDQLE 867

Query: 341  PEEY--PLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEEL 398
             E+Y   L    +   + + EE   L  +LQ +KQ+   E   L   +E        E+L
Sbjct: 868  AEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQL 927

Query: 399  --HVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQG 456
               + +++   LE E   +EL+ K+       E  EK        +       ++  L  
Sbjct: 928  ARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLAN 987

Query: 457  EEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKTYRFSESSE 516
            E+EE      L  KL ++  +L   ++ +     +   FE +L + ER+ KT   ++ +E
Sbjct: 988  EKEE------LNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLT-ERTLKTQAVNKLAE 1040



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 98/408 (24%), Positives = 174/408 (42%), Gaps = 58/408 (14%)

Query: 111 KINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITA 170
           K   L+N+V+ L+ +L +L K N++    Q   EK +N+ +   +E + L+   ++    
Sbjct: 525 KKRNLENDVNSLKDQLEDLKKRNQN---SQISTEK-VNQLQRQLDETNALLRTESDTAAR 580

Query: 171 LKERLRKSQEKERATEKRVKDTESE---LFRTKFSLQK-LKEISEARHLPERDDLAKKLV 226
           L++   +S ++ +  E   +D + +   L   K  L+K    +  A     RD    +  
Sbjct: 581 LRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRD----RTH 636

Query: 227 SAELKLDDTERRIKELSKNLE-----LSTNSFQRQLLAERKRAYEAHDEN---------K 272
            +E+ ++D + RI  L ++L+     L+    +++ L ER    E    N         K
Sbjct: 637 GSEI-INDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLK 695

Query: 273 VLQK--EVQRLYHKLKEKERELDIKNIY-SNRLPKSSPNKEKELALRKNAACQSDFADLC 329
           V+Q+  E +   HK   K R  D   IY S    KS   KE E  L +    +    +L 
Sbjct: 696 VIQQSLEQEEAEHK-ATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLL 754

Query: 330 TKGVQTME----DFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGEAGILN-- 383
            +  +       D K  +  +  E +   +   E+  +LTL ++ + Q R      L   
Sbjct: 755 LEAEKRCSLLDCDLKQSQQKIN-ELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQ 813

Query: 384 ----PIMEREEKFVTDEELHV--VKQEVEKLEDEW--EREELDKKQKEKASLLEREEKPE 435
                 ++  EK +  E  H+  +K  +EK   E   ER++ D + KE    LE E+   
Sbjct: 814 TQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQ--- 870

Query: 436 WETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRN 483
                Y   +Y  Q + +L+ E EE+ K   L  +L +  +ELQD R+
Sbjct: 871 -----YFSTLYKTQ-VRELKEECEEKTK---LGKELQQKKQELQDERD 909


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 83/387 (21%), Positives = 165/387 (42%), Gaps = 35/387 (9%)

Query: 86   QSLNREPLRKDTDLVTKRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEK 145
            + LNR       D   ++ L   L     ++  + E  +K+  L ++ +    ++ R E 
Sbjct: 1575 EELNRLKRTASEDSCKRKKLEEEL---EGMRRSLKEQAIKITNLTQQLEQASIVKKRSED 1631

Query: 146  ALNKFEDA-------ENEISQLIFRHNNEITALKERLRKSQEKERAT-------EKRVKD 191
             L +  D        +    + + R ++E+ AL+ +L + QE  +         +K ++D
Sbjct: 1632 DLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED 1691

Query: 192  TESELFRTKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTN 251
                L  +K  +++L+ ++E     E   L ++L +  L+ DD  R   E   +   +  
Sbjct: 1692 KSRSLNESKIEIERLQSLTE-NLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATIL 1750

Query: 252  SFQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERE-LDIKN-IYSNRLPKSSPNK 309
              + QL     R  E       LQ+E + L  ++++ +++ L+  N I  ++   +   +
Sbjct: 1751 ELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ 1810

Query: 310  EKELALRKNAACQSDFADLCTKGVQTMED-FKPEEYPLTPETIMCYENKWEEPGHLTLDL 368
            E+E  L K    + D A L     Q +ED     +  L  ET +    + E+   +  DL
Sbjct: 1811 ERESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLEAETRVKQRLECEKQ-QIQNDL 1864

Query: 369  QSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLL 428
               K     +   +  I    EK  ++ E + ++ E+E+L+ E +R E   ++K + S  
Sbjct: 1865 NQWKTQYSRKEEAIRKIESEREK--SEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTR 1922

Query: 429  EREEKPEWETGRYQLGMYPIQNMDKLQ 455
            E + + E E  RYQ      + +DKL+
Sbjct: 1923 ETQSQLETERSRYQ------REIDKLR 1943



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 108/492 (21%), Positives = 201/492 (40%), Gaps = 96/492 (19%)

Query: 78   GVRVGFRSQSLNREPLRKDTDLVT------KRILSARLLKINELQNEVSELQVKLAE--- 128
            G  V  R Q L  E LR+ T + T      K+ L      I +   E+  L+  + +   
Sbjct: 1437 GSEVSQRKQQLEVE-LRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETN 1495

Query: 129  ----LLKENKSLKRLQYRQEKA-------LNKFEDAENEISQL----------------- 160
                L  EN  L+R+QY  +KA       +NK +  E E+++L                 
Sbjct: 1496 DRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQD 1555

Query: 161  IFRHNNEITALKERLRKSQEK---------ERATEKRVKDTESELFRTKFSLQKLK---- 207
            I R  N +  L+ + +K +E+         E + +++  + E E  R     Q +K    
Sbjct: 1556 ITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNL 1615

Query: 208  --EISEARHLPER--DDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKR 263
              ++ +A  + +R  DDL ++    +  L + +R  +EL + L     + +RQLL E++ 
Sbjct: 1616 TQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEEL-RRLSSEVEALRRQLLQEQES 1674

Query: 264  AYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQS 323
              +AH  N+  QK ++     L E + E++     +  L K     E+EL   +N   + 
Sbjct: 1675 VKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEEL---RNLRLEY 1731

Query: 324  DFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQD--------- 374
            D  DL  +G    +  K          +    N+  E   L  DLQ ++++         
Sbjct: 1732 D--DL-RRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQ 1788

Query: 375  ----------RHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWERE----ELDKK 420
                      +  +      + ERE   V  + L   K  +++LEDE  R     E + +
Sbjct: 1789 KQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETR 1848

Query: 421  QKEKASLLERE---EKPEWET--GRYQLGMYPIQNMDKLQGEEEERLKREM--LLAKLNE 473
             K++    +++   +  +W+T   R +  +  I++  +    E+  L+ E+  L A++  
Sbjct: 1849 VKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR 1908

Query: 474  ID----RELQDS 481
            I+    R+L+DS
Sbjct: 1909 IEERCRRKLEDS 1920



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 47/194 (24%), Positives = 90/194 (46%), Gaps = 27/194 (13%)

Query: 90   REPLRKDTDLVTKRILSARLLKINELQNEVSE-------LQVKLAELLKENKSLKRLQYR 142
            RE LR++ +   K+ L A   +I E +N+ ++       L VK+  L ++   L+RL+  
Sbjct: 1777 RENLRQEIEKFQKQALEASN-RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDE 1835

Query: 143  QEKALNKFEDAENEISQLIF----RHNNEITALKERLRKSQEKERATEKRVKDTESELFR 198
              +A +  E AE  + Q +     +  N++   K +  + +E  R  E   + +E E   
Sbjct: 1836 LNRAKSTLE-AETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1894

Query: 199  TKFSLQKLKEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLL 258
             +  +++L+  +E + + ER            KL+D+ R   E    LE   + +QR++ 
Sbjct: 1895 LRSEIERLQ--AEIKRIEER---------CRRKLEDSTR---ETQSQLETERSRYQREID 1940

Query: 259  AERKRAYEAHDENK 272
              R+R Y +H E +
Sbjct: 1941 KLRQRPYGSHRETQ 1954



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 88/415 (21%), Positives = 175/415 (42%), Gaps = 66/415 (15%)

Query: 132  ENKSLKRLQYR-QEKALNKFEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVK 190
            +NK ++RL+   QE+A  ++E  ENE+S++   ++ EI +LK +                
Sbjct: 1323 KNKEIERLKAEFQEEAKRRWE-YENELSKVRNNYDEEIISLKNQF--------------- 1366

Query: 191  DTESELFRTKFSLQKL---KEISEARHLPERDDLAKKLVSAELKLDDTERRIKELSKNLE 247
              E+E+  TK ++ +L   KE   + +  + D+L ++  S   ++   +  + + ++NL 
Sbjct: 1367 --ETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLR 1424

Query: 248  LSTNSFQRQL-----LAERKRAYEA--HDENKVLQKEVQRLYHKLKEKERELDIKNIYSN 300
                  Q+Q      +++RK+  E       ++  +E  R    L +  + +  KN    
Sbjct: 1425 RVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIE 1484

Query: 301  RLPK--SSPNKEKELALRKNAACQS---DFADLCTKGVQTMEDFKPEEYPLTPETIMCYE 355
            RL +       +++    +NA  Q    D     +   +T+   K +E  LT        
Sbjct: 1485 RLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELT-------- 1536

Query: 356  NKWEEPGHLTLDLQSQKQDR----HGEAGILNPIMERE-EKFVTDEELHVVKQEVEKLED 410
                    L +D +   Q+R           N + E + +K   +EEL+ +K+     ED
Sbjct: 1537 -------RLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTAS--ED 1587

Query: 411  EWEREELDKK-QKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLA 469
              +R++L+++ +  + SL E+  K    T + +       ++ K + E++ R +R++L  
Sbjct: 1588 SCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQA-----SIVKKRSEDDLRQQRDVLDG 1642

Query: 470  KLNEIDRELQDSRNLKYPV----LPLLPDFESKLHSPERSPKTYRFSESSERLFN 520
             L E  R  ++ R L   V      LL + ES   +  R+    +  E   R  N
Sbjct: 1643 HLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN 1697



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 90/425 (21%), Positives = 166/425 (39%), Gaps = 53/425 (12%)

Query: 111  KINELQNEVSELQVKLAELLKEN---------KSLKRLQYR--------QEKALNKFEDA 153
            + ++ +N+  +LQ K  +  KEN         K++K  +Y         QE+   K E  
Sbjct: 1131 RFDQQKNDYDQLQ-KARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKRE-Y 1188

Query: 154  ENEISQLIFRHNNEITALKER------LRKSQEKERATEKR--VKDTESELFRTKFSLQK 205
            ENE++++   +N E++ L+ +      + K+  KE + +K    K+  ++L R     + 
Sbjct: 1189 ENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRD 1248

Query: 206  LK-----------EISEARHLPERDDLAKKLVSAEL--KLDDTERRIKELSKNLELSTNS 252
            LK           + +E R   E + L +K   +E+  K    E  +K++ +        
Sbjct: 1249 LKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNAR 1308

Query: 253  FQRQLLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELD-IKNIYSNRLPKSSPNKEK 311
             ++ L    K   + + E + L+ E Q    +  E E EL  ++N Y   +       E 
Sbjct: 1309 HKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFET 1368

Query: 312  ELALRKNAACQSDF-ADLCTKGVQTMEDFKPEEYPLTPETIMCYEN----KWEEPGHLTL 366
            E+ + K    Q     +  T G +   D    E     E I   +N      E    +  
Sbjct: 1369 EINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEE 1428

Query: 367  DLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWER-EELDKKQKEKA 425
            D+Q QK     E       +E E + VT        +  + L+D  +  ++ +K+ +   
Sbjct: 1429 DIQQQKA-TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLK 1487

Query: 426  SLLEREEKP----EWETGRYQLGMYPIQNMDKLQGEEEERLK-REMLLAKLNEIDRELQD 480
             L+++E       E E  R Q   Y +Q  +    E   +LK +E  L +L      +  
Sbjct: 1488 QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQ 1547

Query: 481  SRNLK 485
             R +K
Sbjct: 1548 ERTVK 1552


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 91/425 (21%), Positives = 187/425 (44%), Gaps = 51/425 (12%)

Query: 111  KINELQNEV-------SELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFR 163
            K+++LQNEV       +E + K  +L K+  SL       ++ L +    +  +S  + +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 164  HNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEISEA------RHLPE 217
               E  +L+++L +  E ++  E+ +     +L  +K  LQ      EA      R   E
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400

Query: 218  RDDLAKKL---VSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENKVL 274
             ++L ++     +A  KL+ T+ R+++   +L +  ++ QRQL++  ++     D+    
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN-QRQLVSNLEKKQRKFDQLLAE 1459

Query: 275  QKEVQRLY----HKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCT 330
            +K +   Y     + + + RE + K +   R  + +   ++EL  R N   +++  DL +
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE-RTNKMLKAEMEDLVS 1518

Query: 331  ------KGVQTMEDFKP------EEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRHGE 378
                  K V  +E  K       EE     E +   E++ +      L L+   Q   G+
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEEL---EDELQATEDAKLRLEVNMQALKGQ 1575

Query: 379  AGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWET 438
                    ER+ +   DE+    ++++++   E+E E L+ ++K++A     ++K E + 
Sbjct: 1576 -------FERDLQ-ARDEQNEEKRRQLQRQLHEYETE-LEDERKQRALAAAAKKKLEGDL 1626

Query: 439  GRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESK 498
               +L     Q    ++G EE   +   L A++ +  REL+D+R  +  +     + E K
Sbjct: 1627 KDLEL-----QADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681

Query: 499  LHSPE 503
              S E
Sbjct: 1682 AKSLE 1686



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 95/408 (23%), Positives = 166/408 (40%), Gaps = 51/408 (12%)

Query: 114  ELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLIFRHNNEITALKE 173
            +L + + + Q K  +LL E K++   +Y  E+   + E  E E   L         AL+E
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISS-KYADERDRAEAEAREKETKALSLAR-----ALEE 1494

Query: 174  RLRKSQEKERATEKRVKDTESELFRTKFSLQK-LKEISEARHLPER--DDLAKKLVSAEL 230
             L   +E ER T K +K    +L  +K  + K + E+ +++   E   +++  +L   E 
Sbjct: 1495 ALEAKEELER-TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553

Query: 231  KLDDTERRIKELSKNLELSTNSFQRQLLA-----ERKRAY---EAHDENKVLQKE-VQRL 281
            +L  TE     L  N++     F+R L A     E KR     + H+    L+ E  QR 
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613

Query: 282  YHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAACQSDFADLCTKGVQTMEDFKP 341
                 +K+ E D+K++    L   S  K +E A+++    Q+   D      + +ED + 
Sbjct: 1614 LAAAAKKKLEGDLKDL---ELQADSAIKGREEAIKQLRKLQAQMKDF----QRELEDARA 1666

Query: 342  EEYPLTPETIMCYENKWEEPGHLTLDLQSQKQD-RHGEAGILNPIMEREEKFVTDEELHV 400
                   E     +   ++   L  DL   ++D    E       +E+EE     EEL  
Sbjct: 1667 SR----DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE---LAEELAS 1719

Query: 401  VKQEVEKLEDEWEREELDKKQKEKASLLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEE 460
                   L+DE        K++ +A + + EE+ E E G  +     ++   +   +   
Sbjct: 1720 SLSGRNALQDE--------KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771

Query: 461  RLKREMLLAKLNEIDRELQDSRNLKYPVLPLLPDFESKLHSPERSPKT 508
             L  E   A+ NE  R+  + +N          +  SKLH  E + K+
Sbjct: 1772 ELATERSTAQKNESARQQLERQN---------KELRSKLHEMEGAVKS 1810



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 90/414 (21%), Positives = 167/414 (40%), Gaps = 57/414 (13%)

Query: 102  KRILSARLLKINELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQLI 161
            K +L  +L    EL  E  E++V+LA   +E   L+ + +  E  L + ED   ++    
Sbjct: 889  KNLLQEQLQAETELYAEAEEMRVRLAAKKQE---LEEILHEMEARLEEEEDRGQQLQAER 945

Query: 162  FRHNNEITALKERL-------RKSQEKERATEKRVKDTESELF---RTKFSLQKLKEISE 211
             +   ++  L+E+L       +K Q ++   E ++K  E E+         L K +++ E
Sbjct: 946  KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLE 1005

Query: 212  AR------HLPERDDLAKKLVSAELKLDDTERRIKELSKNLELSTNSFQRQLLAERKRAY 265
             R      +L E ++ AK L   + K    E  I EL   L+    S  RQ L + KR  
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNK---HESMISELEVRLKKEEKS--RQELEKLKRKL 1060

Query: 266  EA-----HDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALRKNAA 320
            E      H++   LQ ++  L  +L +KE EL        RL      K    AL+K   
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAA---LARLDDEIAQKNN--ALKKIRE 1115

Query: 321  CQSDFADLCTKGVQTMEDFKPEEYPLTP---------ETIMCYENKWEEPGHLTLDLQSQ 371
             +   +DL        ED   E               E +   + + E+    T   Q  
Sbjct: 1116 LEGHISDL-------QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168

Query: 372  KQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKEKASLLERE 431
            +  R  E  +L   ++ E +    +   + ++  + +E+    E+L++ ++ KA+L + +
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEE--LTEQLEQFKRAKANLDKNK 1226

Query: 432  EKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNEIDRELQDSRNLK 485
            +  E E       +  +      Q ++E   K++ L A++ E+  +  D    +
Sbjct: 1227 QTLEKENADLAGELRVLG-----QAKQEVEHKKKKLEAQVQELQSKCSDGERAR 1275



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 82/406 (20%), Positives = 167/406 (41%), Gaps = 49/406 (12%)

Query: 94   RKDTDLVTKRILSARLLKINELQN-EVSELQVKLAELLKENKSLKRLQYRQE---KALNK 149
            ++   L   +++        +L+N +   L  K+  LL+  +  + +Q +++   K   +
Sbjct: 808  KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867

Query: 150  FEDAENEISQLIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKEI 209
             + AENE+ +L  +H +++T  K  L++  + E       ++    L   K  L+++   
Sbjct: 868  QQKAENELKELEQKH-SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE 926

Query: 210  SEARHLPERD----------DLAKKLVSAELKLDDTE--RRIKELSK-NLELSTNSFQRQ 256
             EAR   E D           +A++++  E +L++ E  R+  +L K   E      + +
Sbjct: 927  MEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 986

Query: 257  LLAERKRAYEAHDENKVLQKEVQRLYHKLKEKERELDIKNIYSNRLPKSSPNKEKELALR 316
            +L    +  +   E K+L++ +  L   L E+E +   KN+   +    S   E E+ L+
Sbjct: 987  ILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK--AKNLTKLKNKHESMISELEVRLK 1044

Query: 317  KNAACQSDFADLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGHLTLDLQSQKQDRH 376
            K    + +   L  K      DF  +   L  +                L +Q  K++  
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI-------------AELKMQLAKKEEE 1091

Query: 377  GEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEW--EREELDKKQKEKASLLEREE-- 432
             +A +     E  +K    +++  ++  +  L+++   ER   +K +K+K  L E  E  
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151

Query: 433  KPEWETGRYQLGMYPIQNMDKLQGEEEERLKREMLLAKLNE-IDRE 477
            K E E             +D    ++E R KRE  +  L + +D E
Sbjct: 1152 KTELE-----------DTLDSTATQQELRAKREQEVTVLKKALDEE 1186



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 88/408 (21%), Positives = 174/408 (42%), Gaps = 61/408 (14%)

Query: 101  TKRILSARLLKIN-ELQNEVSELQVKLAELLKENKSLKRLQYRQEKALNKFEDAENEISQ 159
            +KR L  ++ ++  +L+    ELQ      L+   +++ L+ + E+ L   ++   E  +
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1592

Query: 160  LIFRHNNEITALKERLRKSQEKERATEKRVKDTESELFRTKFSLQKLKE--ISEARHLP- 216
             + R  +E     E  RK +    A +K+++    +L     S  K +E  I + R L  
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652

Query: 217  ERDDLAKKLVSAELKLDD---TERRIKELSKNLELSTNSFQRQLLAERKRAYEAHDENK- 272
            +  D  ++L  A    D+   T +  ++ +K+LE      Q  L A  +   +A  E + 
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712

Query: 273  -------------VLQKEVQRLYHKLKEKERELDIKN----IYSNRLPKSSPNKEK---E 312
                          LQ E +RL  ++ + E EL+ +       S+R+ K++   E+   E
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE 1772

Query: 313  LALRKNAACQSDFA---------DLCTKGVQTMEDFKPEEYPLTPETIMCYENKWEEPGH 363
            LA  ++ A +++ A         +L +K +  ME     ++     TI   E K  +   
Sbjct: 1773 LATERSTAQKNESARQQLERQNKELRSK-LHEMEGAVKSKFK---STIAALEAKIAQ--- 1825

Query: 364  LTLDLQSQKQDRHGEAGILNPIMEREEKFVTDEELHVVKQEVEKLEDEWEREELDKKQKE 423
              L+ Q +++ R  +A   + + ++++K         +K+ + ++EDE +  E  K+Q E
Sbjct: 1826 --LEEQVEQEAREKQAATKS-LKQKDKK---------LKEILLQVEDERKMAEQYKEQAE 1873

Query: 424  KAS-----LLEREEKPEWETGRYQLGMYPIQNMDKLQGEEEERLKREM 466
            K +     L  + E+ E E+ R       +Q       E  E + RE+
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.128    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,189,817
Number of Sequences: 37866
Number of extensions: 1381923
Number of successful extensions: 13352
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 255
Number of HSP's successfully gapped in prelim test: 1013
Number of HSP's that attempted gapping in prelim test: 7085
Number of HSP's gapped (non-prelim): 4218
length of query: 697
length of database: 18,247,518
effective HSP length: 109
effective length of query: 588
effective length of database: 14,120,124
effective search space: 8302632912
effective search space used: 8302632912
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press