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Search of human proteins with 16945972
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16945972 kelch domain containing 3 [Homo sapiens]
(382 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16945972 kelch domain containing 3 [Homo sapiens] 822 0.0
gi|7019405 host cell factor C2 [Homo sapiens] 114 1e-25
gi|98986457 host cell factor 1 [Homo sapiens] 114 2e-25
gi|44917619 kelch domain containing 10 [Homo sapiens] 85 1e-16
gi|7657301 kelch domain containing 2 [Homo sapiens] 84 3e-16
gi|46410931 attractin-like 1 [Homo sapiens] 80 3e-15
gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens] 80 3e-15
gi|26190616 kelch domain containing 1 [Homo sapiens] 74 2e-13
gi|47717139 leucine-zipper-like transcription regulator 1 [Homo ... 74 3e-13
gi|21314675 kelch domain containing 4 [Homo sapiens] 70 2e-12
gi|21450863 attractin isoform 2 [Homo sapiens] 68 2e-11
gi|21450861 attractin isoform 1 [Homo sapiens] 68 2e-11
gi|62955044 F-box protein 42 [Homo sapiens] 67 2e-11
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 62 1e-09
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 62 1e-09
gi|40255071 kelch-like 23 [Homo sapiens] 58 1e-08
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens] 56 5e-08
gi|148664209 kelch-like 10 [Homo sapiens] 55 1e-07
gi|158508542 kelch-like 33 [Homo sapiens] 54 3e-07
gi|31542246 kelch-like 36 [Homo sapiens] 54 3e-07
gi|24308181 kelch-like 9 [Homo sapiens] 54 3e-07
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 52 7e-07
gi|166235129 kelch-like 3 [Homo sapiens] 52 7e-07
gi|45643138 kelch-like 13 [Homo sapiens] 51 2e-06
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 51 2e-06
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 51 2e-06
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 51 2e-06
gi|11056006 kelch-like 12 [Homo sapiens] 50 3e-06
gi|23397572 kelch-like 34 [Homo sapiens] 50 4e-06
gi|38194229 kelch-like 17 [Homo sapiens] 48 1e-05
>gi|16945972 kelch domain containing 3 [Homo sapiens]
Length = 382
Score = 822 bits (2123), Expect = 0.0
Identities = 382/382 (100%), Positives = 382/382 (100%)
Query: 1 MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLP 60
MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLP
Sbjct: 1 MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLP 60
Query: 61 PVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRV 120
PVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRV
Sbjct: 61 PVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRV 120
Query: 121 SGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWR 180
SGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWR
Sbjct: 121 SGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWR 180
Query: 181 DFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRR 240
DFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRR
Sbjct: 181 DFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRR 240
Query: 241 SHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVG 300
SHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVG
Sbjct: 241 SHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVG 300
Query: 301 DKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDI 360
DKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDI
Sbjct: 301 DKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDI 360
Query: 361 RWELNAMTTNSNISRPIVSSHG 382
RWELNAMTTNSNISRPIVSSHG
Sbjct: 361 RWELNAMTTNSNISRPIVSSHG 382
>gi|7019405 host cell factor C2 [Homo sapiens]
Length = 792
Score = 114 bits (285), Expect = 1e-25
Identities = 77/258 (29%), Positives = 124/258 (48%), Gaps = 22/258 (8%)
Query: 73 VPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHS 132
VP R+GH V I + ++++GG N EG + L+ ++ T++WF P V G +P H
Sbjct: 19 VPRARHGHRAVAIRELMIIFGGGN--EGIADELHVYNTATNQWFLPAVRGDIPPGCAAHG 76
Query: 133 ACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICT----KGSPARWRDFHSATML 188
G + +FGG + +SN++++L S W + G P R HS ++
Sbjct: 77 FVCDGTRILVFGGMVEYGR-YSNELYELQASRWLWKKVKPHPPPSGLPPCPRLGHSFSLY 135
Query: 189 GSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTR----TEAWLDCPPTPVLPEGRRSHSA 244
G+ Y+FGG A+ ++N Y N + + W V+P R SH+A
Sbjct: 136 GNKCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVTKGVVPSPRESHTA 195
Query: 245 FGY------NGELYIFGGY-NARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCC 297
Y + ++Y+FGG ARL+ DLW+ + + +W K E KG P PR
Sbjct: 196 VIYCKKDSGSPKMYVFGGMCGARLD----DLWQLDLETMSWSKPETKGTVPLPRSLHTAS 251
Query: 298 IVGDKIVLFGGTSPSPEE 315
++G+K+ +FGG P E
Sbjct: 252 VIGNKMYIFGGWVPHKGE 269
Score = 61.2 bits (147), Expect = 1e-09
Identities = 63/245 (25%), Positives = 101/245 (41%), Gaps = 36/245 (14%)
Query: 14 RVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKS-AIRGQAPV 72
R+ H+ G++ Y FGG + E ++ + ++ + L V +I V
Sbjct: 127 RLGHSFSLYGNKCYLFGGLAN-ESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVTKGV 185
Query: 73 VPYMRYGHSTVLI------DDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPG 126
VP R H+ V+ + ++GG + L+ D+ T W P GTVP
Sbjct: 186 VPSPRESHTAVIYCKKDSGSPKMYVFGGMCGAR--LDDLWQLDLETMSWSKPETKGTVPL 243
Query: 127 ARDGHSACVLGKIMYIFGGY---------EQQADC---FSNDIHKLDTSTMTWTLICT-- 172
R H+A V+G MYIFGG+ DC ++ L+ T WT + +
Sbjct: 244 PRSLHTASVIGNKMYIFGGWVPHKGENTETSPHDCEWRCTSSFSYLNLDTTEWTTLVSDS 303
Query: 173 ----KGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLD 228
K S R R H A +G+ +Y + GR D + N+++ C + DT +
Sbjct: 304 QEDKKNSRPRPRAGHCAVAIGTRLYFWSGR-DGYKK-ALNSQVCCKDLWYLDT------E 355
Query: 229 CPPTP 233
PP P
Sbjct: 356 KPPAP 360
>gi|98986457 host cell factor 1 [Homo sapiens]
Length = 2035
Score = 114 bits (284), Expect = 2e-25
Identities = 84/269 (31%), Positives = 128/269 (47%), Gaps = 24/269 (8%)
Query: 59 LPPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTP 118
L P + G + VP R+GH V I + ++++GG N EG + L+ ++ T++WF P
Sbjct: 15 LQPRWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGN--EGIVDELHVYNTATNQWFIP 72
Query: 119 RVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTK----G 174
V G +P + G + +FGG + +SND+++L S W + K G
Sbjct: 73 AVRGDIPPGCAAYGFVCDGTRLLVFGGMVEYGK-YSNDLYELQASRWEWKRLKAKTPKNG 131
Query: 175 SPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTR----TEAWLDCP 230
P R HS +++G+ Y+FGG A+ +N Y N + + + R AW D P
Sbjct: 132 PPPCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAW-DIP 190
Query: 231 PT-PVLPEGRRSHSAFGYN------GELYIFGGYNA-RLNRHFHDLWKFNPVSFTWKKIE 282
T VLP R SH+A Y +L I+GG + RL DLW + + TW K
Sbjct: 191 ITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLG----DLWTLDIDTLTWNKPS 246
Query: 283 PKGKGPCPRRRQCCCIVGDKIVLFGGTSP 311
G P PR +G+K+ +FGG P
Sbjct: 247 LSGVAPLPRSLHSATTIGNKMYVFGGWVP 275
Score = 73.2 bits (178), Expect = 4e-13
Identities = 80/281 (28%), Positives = 106/281 (37%), Gaps = 42/281 (14%)
Query: 20 VAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMRYG 79
V G R+ FGG Y D++ A W +L K+ G P R G
Sbjct: 88 VCDGTRLLVFGGMVEYGKYSN----DLYELQASRWEWKRLK-AKTPKNGPPPCP---RLG 139
Query: 80 HSTVLIDDTVLLWGG-RNDTEGA-------CNVLYAFDVNTHK----WFTPRVSGTVPGA 127
HS L+ + L+GG ND+E N LY ++ W P G +P
Sbjct: 140 HSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLPPP 199
Query: 128 RDGHSACVLGKI------MYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRD 181
R+ H+A V + + I+GG + C D+ LD T+TW G R
Sbjct: 200 RESHTAVVYTEKDNKKSKLVIYGG---MSGCRLGDLWTLDIDTLTWNKPSLSGVAPLPRS 256
Query: 182 FHSATMLGSHMYVFGG-----RADRFGPFHSNNEIYCNRIRVFDTRTEAW---LDCPPTP 233
HSAT +G+ MYVFGG D H N + + T AW L
Sbjct: 257 LHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLED 316
Query: 234 VLPEGRRSHSAFGYNGELYIFG---GYNARLNRHF--HDLW 269
+P R H A N LYI+ GY N DLW
Sbjct: 317 NIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLW 357
Score = 65.1 bits (157), Expect = 1e-10
Identities = 63/248 (25%), Positives = 106/248 (42%), Gaps = 45/248 (18%)
Query: 14 RVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAP-- 71
R+ H+ VG++ Y FGG + D E + N L +L P + P
Sbjct: 137 RLGHSFSLVGNKCYLFGGLAN--DSEDPKNNIPRYLN--DLYILELRPGSGVVAWDIPIT 192
Query: 72 --VVPYMRYGHSTVLIDD------TVLLWGGRNDTEGACNV--LYAFDVNTHKWFTPRVS 121
V+P R H+ V+ + ++++GG + C + L+ D++T W P +S
Sbjct: 193 YGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMS----GCRLGDLWTLDIDTLTWNKPSLS 248
Query: 122 GTVPGARDGHSACVLGKIMYIFGG-------------YEQQADCFSNDIHKLDTSTMTWT 168
G P R HSA +G MY+FGG +E++ C +N + L+ TM W
Sbjct: 249 GVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKC-TNTLACLNLDTMAWE 307
Query: 169 LI---CTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEA 225
I + + R R H A + + +Y++ GR + NN++ C + +T
Sbjct: 308 TILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAW--NNQVCCKDLWYLET---- 361
Query: 226 WLDCPPTP 233
+ PP P
Sbjct: 362 --EKPPPP 367
Score = 57.0 bits (136), Expect = 3e-08
Identities = 44/167 (26%), Positives = 72/167 (43%), Gaps = 17/167 (10%)
Query: 174 GSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTP 233
G R R H A + + VFGG NE + + V++T T W
Sbjct: 27 GPVPRPRHGHRAVAIKELIVVFGG----------GNEGIVDELHVYNTATNQWFIPAVRG 76
Query: 234 VLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPK----GKGPC 289
+P G ++ L +FGG ++ +DL++ + WK+++ K G PC
Sbjct: 77 DIPPGCAAYGFVCDGTRLLVFGGM-VEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPC 135
Query: 290 PRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSP 336
PR +VG+K LFGG + E+ + + +DL+IL+ P
Sbjct: 136 PRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYL--NDLYILELRP 180
>gi|44917619 kelch domain containing 10 [Homo sapiens]
Length = 442
Score = 84.7 bits (208), Expect = 1e-16
Identities = 76/291 (26%), Positives = 113/291 (38%), Gaps = 45/291 (15%)
Query: 12 PRRVNHAAVAVGHRVYSFGGY---------CSGEDYETLRQI-DVHIFNAVSLRWTKLPP 61
P R H VA +Y FGGY EDY R++ H V W ++
Sbjct: 90 PARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGV---WHQM-- 144
Query: 62 VKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGAC--NVLYAFDVNTHKWFTPR 119
G +P S VL + +L++GG G N ++ +V +W
Sbjct: 145 ------GTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLS 198
Query: 120 VSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKG----- 174
G P G + ++ +Y+FGG +S D+HKLD +T WT +
Sbjct: 199 CRGKKPSRIYGQAMAIINGSLYVFGG--TTGYIYSTDLHKLDLNTREWTQLKPNNLSCDL 256
Query: 175 SPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTP- 233
R+R H G +Y+ GG S N+I ++ T AW + P
Sbjct: 257 PEERYR--HEIAHDGQRIYILGGGT-------SWTAYSLNKIHAYNLETNAWEEIATKPH 307
Query: 234 ---VLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKI 281
P RR HS +++I GGYN + D+WK N +F W K+
Sbjct: 308 EKIGFPAARRCHSCVQIKNDVFICGGYNGEV--ILGDIWKLNLQTFQWVKL 356
Score = 64.7 bits (156), Expect = 1e-10
Identities = 72/274 (26%), Positives = 115/274 (41%), Gaps = 38/274 (13%)
Query: 23 GHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMRYGHST 82
G+ + FGG +G + DVH+ N RW L + RG+ P YG +
Sbjct: 163 GNNLLVFGG--TGIPFGESNGNDVHVCNVKYKRWALL-----SCRGKKPS---RIYGQAM 212
Query: 83 VLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPR---VSGTVPGARDGHSACVLGKI 139
+I+ ++ ++GG + + L+ D+NT +W + +S +P R H G+
Sbjct: 213 AIINGSLYVFGGTTGYIYSTD-LHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQR 271
Query: 140 MYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTK-----GSPARWRDFHSATMLGSHMYV 194
+YI GG N IH + T W I TK G PA R HS + + +++
Sbjct: 272 IYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAA-RRCHSCVQIKNDVFI 330
Query: 195 FGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSH-SAFGYNGELYI 253
GG N E+ I + +T W+ P T +PE H +A G +YI
Sbjct: 331 CGG---------YNGEVILGDIWKLNLQTFQWVKLPAT--MPEPVYFHCAAVTPAGCMYI 379
Query: 254 FGG-YNARLNRHFHDLWKF-----NPVSFTWKKI 281
GG N N+ L+K + + W+K+
Sbjct: 380 HGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKL 413
Score = 62.0 bits (149), Expect = 9e-10
Identities = 65/263 (24%), Positives = 103/263 (39%), Gaps = 32/263 (12%)
Query: 66 IRGQAPVVPYMRYGHSTVLIDDTVLLWGGRN----DTEGACNV-------LYAFDVNTHK 114
+RG P P R GH V + + ++GG N ++ G N L+ + T
Sbjct: 83 LRGHRP--PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGV 140
Query: 115 WFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQ-ADCFSNDIHKLDTSTMTWTLICTK 173
W G +P S + G + +FGG + ND+H + W L+ +
Sbjct: 141 WHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCR 200
Query: 174 GS-PARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPT 232
G P+R A + GS +YVFGG + IY + D T W P
Sbjct: 201 GKKPSRIYGQAMAIINGS-LYVFGG---------TTGYIYSTDLHKLDLNTREWTQLKPN 250
Query: 233 PV---LPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKI--EPKGKG 287
+ LPE R H +YI GG + + + +N + W++I +P K
Sbjct: 251 NLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKI 310
Query: 288 PCPRRRQC--CCIVGDKIVLFGG 308
P R+C C + + + + GG
Sbjct: 311 GFPAARRCHSCVQIKNDVFICGG 333
Score = 42.7 bits (99), Expect = 5e-04
Identities = 24/95 (25%), Positives = 40/95 (42%), Gaps = 10/95 (10%)
Query: 236 PEGRRSHSAFGYNGELYIFGGYNARLNRH----------FHDLWKFNPVSFTWKKIEPKG 285
P R H N LY+FGGYN + F +LW+++ + W ++ G
Sbjct: 89 PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDG 148
Query: 286 KGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDE 320
P + G+ +++FGGT E G++
Sbjct: 149 YMPRELASMSLVLHGNNLLVFGGTGIPFGESNGND 183
Score = 38.5 bits (88), Expect = 0.010
Identities = 43/190 (22%), Positives = 70/190 (36%), Gaps = 17/190 (8%)
Query: 176 PARWRDFHSATMLGSHMYVFGGRADRF----GPFHSNNEIYCNRIRVFDTRTEAWLDCPP 231
P R H +++YVFGG + GP + + ++ R + T W
Sbjct: 88 PPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWR-YHFATGVWHQMGT 146
Query: 232 TPVLPEGRRSHSAFGYNGELYIFGGYNARLNR-HFHDLWKFNPVSFTWKKIEPKGKGPCP 290
+P S S + L +FGG + +D+ N W + +GK P
Sbjct: 147 DGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSR 206
Query: 291 RRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYN 350
Q I+ + +FGGT+ I +DLH LD + T K + +
Sbjct: 207 IYGQAMAIINGSLYVFGGTT-----------GYIYSTDLHKLDLNTREWTQLKPNNLSCD 255
Query: 351 LDQSCLPHDI 360
L + H+I
Sbjct: 256 LPEERYRHEI 265
>gi|7657301 kelch domain containing 2 [Homo sapiens]
Length = 406
Score = 83.6 bits (205), Expect = 3e-16
Identities = 101/403 (25%), Positives = 158/403 (39%), Gaps = 72/403 (17%)
Query: 14 RVNHAAVAVGHRVYSFGGYCSGE-----DYETLRQIDVHIFNAVSLRWTKLPPVKSAIRG 68
R H AV+ G ++ +GGY S + D+ R+ ++ I+N + RW K I
Sbjct: 32 RSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPRE-ELWIYNMETGRWKK-------INT 83
Query: 69 QAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTH----KWFTPRVSGTV 124
+ V P M G V +D + L+GG + + G N Y D + +W G
Sbjct: 84 EGDVPPSMS-GSCAVCVDRVLYLFGGHH-SRGNTNKFYMLDSRSTDRVLQWERIDCQGIP 141
Query: 125 PGARDGHSACVLGKIMYIFGGY------------EQQADCFSND---------IHKLDTS 163
P ++D V + FGGY E F N +H LDT
Sbjct: 142 PSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTE 201
Query: 164 TMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRT 223
T TW+ T G R H+ +G+ +VFGGR + N + + T
Sbjct: 202 TFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGR---------YRDARMNDLHYLNLDT 252
Query: 224 EAWLDCPPTPVLPEGRRSHSAFGYNGE-LYIFGGYNARLNRHFHDLWKFNPVSFTWKKI- 281
W + P + P GR HS + + L++FGG+ + D W + W +
Sbjct: 253 WEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTD-KQPLSDAWTYCISKNEWIQFN 311
Query: 282 EPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLH---ILDFSPSL 338
P + P C G+ +++FGG + + L+ H H IL FS
Sbjct: 312 HPYTEKPRLWHTACASDEGE-VIVFGGCANNL---------LVHHRAAHSNEILIFSVQP 361
Query: 339 KTLCKL---AVIQYN----LDQSCLPHDIRWELNAMTTNSNIS 374
K+L +L AVI + +CLP + +N ++N S
Sbjct: 362 KSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTS 404
Score = 58.5 bits (140), Expect = 1e-08
Identities = 56/217 (25%), Positives = 81/217 (37%), Gaps = 43/217 (19%)
Query: 125 PGARDGHSACVLGKIMYIFGGYEQQA-----DCF--SNDIHKLDTSTMTWTLICTKGSPA 177
P R GH A G+ M+++GGY+ D + ++ + T W I T+G
Sbjct: 29 PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVP 88
Query: 178 RWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAW--LDCPPTPVL 235
A + +Y+FGG R + N+ Y R D R W +DC P
Sbjct: 89 PSMSGSCAVCVDRVLYLFGGHHSR----GNTNKFYMLDSRSTD-RVLQWERIDCQGIP-- 141
Query: 236 PEGRRSHSAFGYNGELYIFGGYN------------------------ARLNRHFHDLWKF 271
P + + Y +L FGGY N H H L
Sbjct: 142 PSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHIL--- 198
Query: 272 NPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGG 308
+ +FTW + GK P PR C VG++ +FGG
Sbjct: 199 DTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGG 235
>gi|46410931 attractin-like 1 [Homo sapiens]
Length = 1379
Score = 80.1 bits (196), Expect = 3e-15
Identities = 67/276 (24%), Positives = 117/276 (42%), Gaps = 27/276 (9%)
Query: 11 GP-RRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRW-TKLPPVKSAIRG 68
GP +R H+ ++ +GG D ++ +FN S W TK P V G
Sbjct: 351 GPLQRYGHSLALYQENIFMYGGRIETNDGNVTDEL--WVFNIHSQSWSTKTPTVLG--HG 406
Query: 69 QAPVVPYMRYGHSTVLI-----DDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGT 123
Q Y GHS ++ D +++ G + G + + + ++++ W P G
Sbjct: 407 QQ----YAVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHISSNTWLVPETKGA 462
Query: 124 VPGARDGHSACV--LGKIMYIFGGYEQQADC---FSNDIHKLDTSTMTWTLICTKGSPAR 178
+ GH++ + K +Y+ GGY+ +D++K + +T TWT++ G
Sbjct: 463 IVQGGYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFA-- 520
Query: 179 WRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCP-PTPVLPE 237
R HSA ++ M +FGG + + + +D + W P P
Sbjct: 521 -RYLHSAVLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKILPKPNLHRDV 579
Query: 238 GRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNP 273
R HSA NG +YIFGG+++ L +D+ + P
Sbjct: 580 NRFGHSAVVINGSMYIFGGFSSVL---LNDILVYKP 612
Score = 64.7 bits (156), Expect = 1e-10
Identities = 68/258 (26%), Positives = 111/258 (43%), Gaps = 39/258 (15%)
Query: 14 RVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVV 73
R +H AV G ++ GGY +Y + + V +N S W P +
Sbjct: 305 RASHKAVLHGKFMWVIGGYTF--NYSSFQM--VLNYNLESSIWNVGTPSRG--------- 351
Query: 74 PYMRYGHSTVLIDDTVLLWGGRNDTE--GACNVLYAFDVNTHKWF--TPRVSG-TVPGAR 128
P RYGHS L + + ++GGR +T + L+ F++++ W TP V G A
Sbjct: 352 PLQRYGHSLALYQENIFMYGGRIETNDGNVTDELWVFNIHSQSWSTKTPTVLGHGQQYAV 411
Query: 129 DGHSACVL-----GKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFH 183
+GHSA ++ +M I GY +++ I + S+ TW + TKG+ + H
Sbjct: 412 EGHSAHIMELDSRDVVMIIIFGYSAIYG-YTSSIQEYHISSNTWLVPETKGAIVQGGYGH 470
Query: 184 SATM--LGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPE---G 238
++ + +YV GG + N + + ++ T+ W +L E
Sbjct: 471 TSVYDEITKSIYVHGG----YKALPGNKYGLVDDLYKYEVNTKTW------TILKESGFA 520
Query: 239 RRSHSAFGYNGELYIFGG 256
R HSA NG + IFGG
Sbjct: 521 RYLHSAVLINGAMLIFGG 538
Score = 34.7 bits (78), Expect = 0.15
Identities = 39/156 (25%), Positives = 61/156 (39%), Gaps = 16/156 (10%)
Query: 131 HSACVL-GKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKG-SPARWRDFHSATML 188
H C L G+ + + Q DC N + ++ W L K SP+ R H A +
Sbjct: 258 HGYCDLTGEKLCVCNDSWQGPDCSLN----VPSTESYWILPNVKPFSPSVGRASHKAVLH 313
Query: 189 GSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYN 248
G M+V GG + F + ++ + W P+ P R HS Y
Sbjct: 314 GKFMWVIGGYTFNYSSF--------QMVLNYNLESSIWNVGTPSRG-PLQRYGHSLALYQ 364
Query: 249 GELYIFGGYNARLNRHFHD-LWKFNPVSFTWKKIEP 283
++++GG + + D LW FN S +W P
Sbjct: 365 ENIFMYGGRIETNDGNVTDELWVFNIHSQSWSTKTP 400
Score = 30.0 bits (66), Expect = 3.6
Identities = 24/95 (25%), Positives = 40/95 (42%), Gaps = 11/95 (11%)
Query: 4 WTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGE----DYETLRQIDVHIFNAVSLRWTKL 59
WT+ E G R H+AV + + FGG + + D ++ W L
Sbjct: 511 WTILKESGFARYLHSAVLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKIL 570
Query: 60 PPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGG 94
P K + R+GHS V+I+ ++ ++GG
Sbjct: 571 P--KPNLHRDV-----NRFGHSAVVINGSMYIFGG 598
>gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]
Length = 372
Score = 80.1 bits (196), Expect = 3e-15
Identities = 69/256 (26%), Positives = 103/256 (40%), Gaps = 36/256 (14%)
Query: 74 PYMRYGHSTVLIDDT-------VLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPG 126
P R GHS + V + GG N +V + D+ H+W G +P
Sbjct: 28 PCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDV-HTMDLGKHQWDLDTCKGLLP- 85
Query: 127 ARDGHSA----CVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDF 182
R H++ C +I ++FGG Q + N + L+ T TWT P R F
Sbjct: 86 -RYEHASFIPSCTPDRI-WVFGGANQSGN--RNCLQVLNPETRTWTTPEVTSPPPSPRTF 141
Query: 183 H-SATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAW-----LDCPPTPVLP 236
H S+ +G+ +YVFGG P ++ VFD T W L PP+P
Sbjct: 142 HTSSAAIGNQLYVFGGGERGAQPVQDT------KLHVFDANTLTWSQPETLGNPPSP--- 192
Query: 237 EGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCC 296
R H +L+I GG +R + DL + W+K+ P G P
Sbjct: 193 --RHGHVMVAAGTKLFIHGGLAG--DRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSA 248
Query: 297 CIVGDKIVLFGGTSPS 312
+G + +FGG +P+
Sbjct: 249 VAMGKHVYIFGGMTPA 264
Score = 75.1 bits (183), Expect = 1e-13
Identities = 60/220 (27%), Positives = 89/220 (40%), Gaps = 23/220 (10%)
Query: 25 RVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMRYGHSTVL 84
R++ FGG + L+ + N + WT P V S P P + S +
Sbjct: 100 RIWVFGGANQSGNRNCLQ-----VLNPETRTWTT-PEVTSP-----PPSPRTFHTSSAAI 148
Query: 85 IDDTVLLWGGRNDTEGACNV-LYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIF 143
+ + GG + + L+ FD NT W P G P R GH G ++I
Sbjct: 149 GNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIH 208
Query: 144 GGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFG 203
GG D F +D+H +D S M W + G+ HSA +G H+Y+FGG
Sbjct: 209 GGLA--GDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMT---- 262
Query: 204 PFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHS 243
P + + +Y + T + W +LP GR HS
Sbjct: 263 PAGALDTMY-----QYHTEEQHWTLLKFDTLLPPGRLDHS 297
Score = 68.9 bits (167), Expect = 7e-12
Identities = 65/235 (27%), Positives = 95/235 (40%), Gaps = 40/235 (17%)
Query: 115 WFTPRVSGTVPGARDGHSACVL--------GKIMYIFGGYEQQADCFSNDIHKLDTSTMT 166
W+T V G P AR GHS L GK+ + G ++ +D+H +D
Sbjct: 18 WYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRS---FSDVHTMDLGKHQ 74
Query: 167 WTLICTKGSPARWRDFHSA---TMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRT 223
W L KG R+ H++ + ++VFGG +N N ++V + T
Sbjct: 75 WDLDTCKGLLPRYE--HASFIPSCTPDRIWVFGG---------ANQSGNRNCLQVLNPET 123
Query: 224 EAWLDCPPTPVLPEGRRSH-SAFGYNGELYIFGGYNARLNRHFHD--LWKFNPVSFTWKK 280
W T P R H S+ +LY+FGG R + D L F+ + TW +
Sbjct: 124 RTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG-GERGAQPVQDTKLHVFDANTLTWSQ 182
Query: 281 IEPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFS 335
E G P PR G K+ + GG + GD F + DLH +D S
Sbjct: 183 PETLGNPPSPRHGHVMVAAGTKLFIHGGLA-------GDRF----YDDLHCIDIS 226
Score = 61.2 bits (147), Expect = 1e-09
Identities = 41/159 (25%), Positives = 75/159 (47%), Gaps = 13/159 (8%)
Query: 12 PRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAP 71
PR + ++ A+G+++Y FGG G + ++ +H+F+A +L W++ + +
Sbjct: 138 PRTFHTSSAAIGNQLYVFGGGERGA--QPVQDTKLHVFDANTLTWSQPETLGNP------ 189
Query: 72 VVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGH 131
P R+GH V + + GG + + L+ D++ KW +G P H
Sbjct: 190 --PSPRHGHVMVAAGTKLFIHGGLAG-DRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAH 246
Query: 132 SACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLI 170
SA +GK +YIFGG + +++ T WTL+
Sbjct: 247 SAVAMGKHVYIFGGMTPAGAL--DTMYQYHTEEQHWTLL 283
Score = 50.4 bits (119), Expect = 3e-06
Identities = 32/123 (26%), Positives = 51/123 (41%), Gaps = 14/123 (11%)
Query: 14 RVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVV 73
R H VA G +++ GG Y+ D+H + ++W KL P +A G A
Sbjct: 193 RHGHVMVAAGTKLFIHGGLAGDRFYD-----DLHCIDISDMKWQKLNPTGAAPAGCA--- 244
Query: 74 PYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSA 133
HS V + V ++GG GA + +Y + W + +P R HS
Sbjct: 245 -----AHSAVAMGKHVYIFGGMTPA-GALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSM 298
Query: 134 CVL 136
C++
Sbjct: 299 CII 301
>gi|26190616 kelch domain containing 1 [Homo sapiens]
Length = 406
Score = 74.3 bits (181), Expect = 2e-13
Identities = 72/261 (27%), Positives = 115/261 (44%), Gaps = 32/261 (12%)
Query: 77 RYGHSTVLIDDTVLLWGGR-----NDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGH 131
R GH V+ + + +WGG N+ + ++ +D+++ W + G +P + G
Sbjct: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGS 72
Query: 132 -SACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTK-----GSPARWRDFHSA 185
AC+ GK+ YIFGGY+ + +SN ++ ++ T T I K G P RD S
Sbjct: 73 CGACINGKL-YIFGGYDDKG--YSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSC 129
Query: 186 TMLGSHMYVFGGRA--------DRFGPFHSNNEI-----YCNRIRVFDTRTEAWLDCP-P 231
+ + FGG D F ++ E + N + +FDT+T+ W
Sbjct: 130 WVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWFQPEIK 189
Query: 232 TPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWK-KIEPKGKGPCP 290
V P+ R +H+ + YIFGG L +DL N ++TW +I G+ P
Sbjct: 190 GGVPPQPRAAHTCAVLGNKGYIFGG--RVLQTRMNDLHYLNLDTWTWSGRITINGESPKH 247
Query: 291 RR-RQCCCIVGDKIVLFGGTS 310
R I DK+ L GG S
Sbjct: 248 RSWHTLTPIADDKLFLCGGLS 268
Score = 68.9 bits (167), Expect = 7e-12
Identities = 86/328 (26%), Positives = 136/328 (41%), Gaps = 54/328 (16%)
Query: 14 RVNHAAVAVGHRVYSFGGYCSGEDYET-LRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPV 72
R H AV G+ +Y +GGY S ED E L ++ ++ S W + G+
Sbjct: 13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWR-----MHLMEGE--- 64
Query: 73 VPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNT--HKWFTPRVS---GTVPGA 127
+P G I+ + ++GG +D +G N LY ++ T + +++ G P
Sbjct: 65 LPASMSGSCGACINGKLYIFGGYDD-KGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTP 123
Query: 128 RDGHSACVLGKIMYIFGGY-----EQQADCFS---------------NDIHKLDTSTMTW 167
RD S V + FGGY + DCF ND+H DT T TW
Sbjct: 124 RDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTW 183
Query: 168 TLICTKGS-PARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAW 226
KG P + R H+ +LG+ Y+FGGR + N + + T W
Sbjct: 184 FQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRV---------LQTRMNDLHYLNLDTWTW 234
Query: 227 LD-CPPTPVLPEGRRSHSAFGY-NGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIE-- 282
P+ R H+ + +L++ GG +A N D W N + WK++
Sbjct: 235 SGRITINGESPKHRSWHTLTPIADDKLFLCGGLSAD-NIPLSDGWIHNVTTNCWKQLTHL 293
Query: 283 PKGKGPCPRRRQCCCI-VGDKIVLFGGT 309
PK + PR C+ ++I++FGG+
Sbjct: 294 PKTR---PRLWHTACLGKENEIMVFGGS 318
Score = 66.2 bits (160), Expect = 5e-11
Identities = 53/185 (28%), Positives = 81/185 (43%), Gaps = 27/185 (14%)
Query: 177 ARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYC--NRIRVFDTRTEAWLDCPPTPV 234
A R H A + G+ +YV+GG +NE+Y + I +D + W
Sbjct: 10 AEERSGHCAVVDGNFLYVWGGYVSI-----EDNEVYLPNDEIWTYDIDSGLWRMHLMEGE 64
Query: 235 LPEGRRSHSAFGYNGELYIFGGYNAR--LNRHFHDLWKFNPVSFTWKKIEP-KGKGPCPR 291
LP NG+LYIFGGY+ + NR + + ++ W+KI +G+ P PR
Sbjct: 65 LPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPR 124
Query: 292 RRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLID-----------HSDLHILD------F 334
+ C + D+++ FGG L D FD+ D H+D+HI D F
Sbjct: 125 DKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTWF 184
Query: 335 SPSLK 339
P +K
Sbjct: 185 QPEIK 189
>gi|47717139 leucine-zipper-like transcription regulator 1 [Homo
sapiens]
Length = 840
Score = 73.6 bits (179), Expect = 3e-13
Identities = 67/269 (24%), Positives = 113/269 (42%), Gaps = 31/269 (11%)
Query: 55 RWTKLPPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHK 114
RW +LPP + + R H+ V D + ++GG N + N L FDV
Sbjct: 53 RWRRLPPCDEFVGAR-------RSKHTVVAYKDAIYVFGGDNG-KTMLNDLLRFDVKDCS 104
Query: 115 WFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFS-------NDIHKLDTSTMTW 167
W +GT P R HSA V G M++FGGY D +S ND+ + +T W
Sbjct: 105 WCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGY--TGDIYSNSNLKNKNDLFEYKFATGQW 162
Query: 168 TLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWL 227
T +G R H AT+ +++F G + N+++ I + D W
Sbjct: 163 TEWKIEGRLPVARSAHGATVYSDKLWIFAG----YDGNARLNDMW--TIGLQDRELTCWE 216
Query: 228 DCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEP---- 283
+ + +P + ++++F G + + ++L++F TW +I
Sbjct: 217 EVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGA--KITNNLFQFEFKDKTWTRIPTEHLL 274
Query: 284 KGKGPCPRRRQCCCIVG--DKIVLFGGTS 310
+G P P+RR +V + +FGG +
Sbjct: 275 RGSPPPPQRRYGHTMVAFDRHLYVFGGAA 303
Score = 65.1 bits (157), Expect = 1e-10
Identities = 73/310 (23%), Positives = 126/310 (40%), Gaps = 35/310 (11%)
Query: 14 RVNHAAVAVGHRVYSFGGYCSGEDYETLR---QIDVHIFNAVSLRWTKLPPVKSAIRGQA 70
R +H+AV G ++ FGGY +G+ Y + D+ + + +WT+ I G+
Sbjct: 118 RYHHSAVVYGSSMFVFGGY-TGDIYSNSNLKNKNDLFEYKFATGQWTEWK-----IEGRL 171
Query: 71 PVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHK---WFTPRVSGTVPGA 127
PV R H + D + ++ G D N ++ + + W SG +P +
Sbjct: 172 PVA---RSAHGATVYSDKLWIFAGY-DGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPS 227
Query: 128 RDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICT----KGSPA--RWRD 181
V M++F G Q +N++ + + TWT I T +GSP + R
Sbjct: 228 CCNFPVAVCRDKMFVFSG--QSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRY 285
Query: 182 FHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRS 241
H+ H+YVFGG AD P NE++C +D + W P+ G
Sbjct: 286 GHTMVAFDRHLYVFGGAADNTLP----NELHC-----YDVDFQTWEVVQPSSDSEVGGAE 336
Query: 242 HSAFGYNGELYIFGGYNARLN-RHFHDLWKFNPVSFTWKK-IEPKGKGPCPRRRQCCCIV 299
E Y R+ + D++ + + + K+ +P + P R ++
Sbjct: 337 VPERACASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVI 396
Query: 300 GDKIVLFGGT 309
D + +FGGT
Sbjct: 397 SDAMYIFGGT 406
Score = 55.5 bits (132), Expect = 8e-08
Identities = 52/193 (26%), Positives = 78/193 (40%), Gaps = 14/193 (7%)
Query: 12 PRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAP 71
P N +++ F G + L Q F WT++P + +RG P
Sbjct: 226 PSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQ-----FEFKDKTWTRIP-TEHLLRGSPP 279
Query: 72 VVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKW--FTPRVSGTVPGARD 129
P RYGH+ V D + ++GG D N L+ +DV+ W P V GA
Sbjct: 280 P-PQRRYGHTMVAFDRHLYVFGGAADNT-LPNELHCYDVDFQTWEVVQPSSDSEVGGAEV 337
Query: 130 GHSACVLGKIMYIFGGYEQQADCF-SNDIHKLDTSTMTWTLICTKGSPA-RWRDFHSATM 187
AC ++ + YE++ S D+ LD T + S R FH+A +
Sbjct: 338 PERACASEEVPTLT--YEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAV 395
Query: 188 LGSHMYVFGGRAD 200
+ MY+FGG D
Sbjct: 396 ISDAMYIFGGTVD 408
>gi|21314675 kelch domain containing 4 [Homo sapiens]
Length = 520
Score = 70.5 bits (171), Expect = 2e-12
Identities = 52/179 (29%), Positives = 82/179 (45%), Gaps = 13/179 (7%)
Query: 140 MYIFGG--YEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATML---GSHMYV 194
+ +FGG + Q N+++ +T TWT + P R R H A ++ G ++V
Sbjct: 78 LILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPPR-RCAHQAVVVPQGGGQLWV 136
Query: 195 FGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIF 254
FGG F + + + V T+ W T P GR H + +L +F
Sbjct: 137 FGGE---FASPNGEQFYHYKDLWVLHLATKTWEQVKSTGG-PSGRSGHRMVAWKRQLILF 192
Query: 255 GGYN--ARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRR-QCCCIVGDKIVLFGGTS 310
GG++ R +++D++ FN +FTW K+ P G GP PR Q IV++GG S
Sbjct: 193 GGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYS 251
Score = 53.5 bits (127), Expect = 3e-07
Identities = 66/275 (24%), Positives = 104/275 (37%), Gaps = 42/275 (15%)
Query: 87 DTVLLWGGR---NDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVL---GKIM 140
D ++L+GG N LY ++ W + P R H A V+ G +
Sbjct: 76 DELILFGGEYFNGQKTFLYNELYVYNTRKDTWTKVDIPSPPP-RRCAHQAVVVPQGGGQL 134
Query: 141 YIFGGY--EQQADCFSN--DIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFG 196
++FGG + F + D+ L +T TW + + G P+ R H + +FG
Sbjct: 135 WVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGGPSG-RSGHRMVAWKRQLILFG 193
Query: 197 GRADRFGPFHSNNE--IYCNRIRVFDTRTEAWLDCPPTPVLPEGRRS-HSAFGYNGELYI 253
G FH + IY N + F+ T W P+ P R + G + +
Sbjct: 194 G-------FHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVV 246
Query: 254 FGGYNARL--------NRHFHDLWKFNPVS-----FTWKKIEPKGKGPCPRRRQCCCIVG 300
+GGY+ + RH D++ P + W ++ P G P PR +
Sbjct: 247 YGGYSKQRVKKDVDKGTRH-SDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAMAP 305
Query: 301 DKIVLF--GGTSPSPEEGLGDEFDLIDHSDLHILD 333
+ LF G EE L EF +DL+ D
Sbjct: 306 NHQTLFFGGVCDEEEEESLSGEF----FNDLYFYD 336
Score = 48.1 bits (113), Expect = 1e-05
Identities = 58/239 (24%), Positives = 92/239 (38%), Gaps = 33/239 (13%)
Query: 12 PRRVNHAAVAV---GHRVYSFGG-YCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIR 67
PRR H AV V G +++ FGG + S + D+ + + + W ++
Sbjct: 117 PRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQVKSTGG--- 173
Query: 68 GQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGAC---NVLYAFDVNTHKWFTPRVSGTV 124
P R GH V ++L+GG +++ N +YAF+++T W SGT
Sbjct: 174 ------PSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTG 227
Query: 125 PGARDGHSACVL--GKIMYIFGGYEQQ------------ADCFSNDIHKLDTSTMTWTLI 170
P R G V G I+ ++GGY +Q +D F WT +
Sbjct: 228 PTPRSGCQMSVTPQGGIV-VYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVWTRM 286
Query: 171 CTKGSPARWRDFHSATMLGSHMYV-FGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLD 228
G R S M +H + FGG D + E + N + +D W +
Sbjct: 287 NPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFF-NDLYFYDATRNRWFE 344
>gi|21450863 attractin isoform 2 [Homo sapiens]
Length = 1272
Score = 67.8 bits (164), Expect = 2e-11
Identities = 58/262 (22%), Positives = 108/262 (41%), Gaps = 22/262 (8%)
Query: 13 RRVNHAAVAVGH-------RVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSA 65
R VN+ V GH ++Y +GG T HI N + T + A
Sbjct: 384 RSVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYA 443
Query: 66 IRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVP 125
+ G + + ++ G +L+ G G + + +D++ + W G +
Sbjct: 444 VVGHSAHIVTLKNGRVVMLVIF------GHCPLYGYISNVQEYDLDKNTWSILHTQGALV 497
Query: 126 GARDGHSACV--LGKIMYIFGGYEQ-QADCF--SNDIHKLDTSTMTWTLICTKGSPARWR 180
GHS+ + +Y+ GGY+ A+ + ++D+++ D T WT++ +R
Sbjct: 498 QGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTIL---KDSRFFR 554
Query: 181 DFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRR 240
H+A ++ M VFGG + + + +D + W P + + R
Sbjct: 555 YLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVNR 614
Query: 241 -SHSAFGYNGELYIFGGYNARL 261
HSA +N +Y+FGG+N+ L
Sbjct: 615 FGHSAVLHNSTMYVFGGFNSLL 636
Score = 47.0 bits (110), Expect = 3e-05
Identities = 51/244 (20%), Positives = 92/244 (37%), Gaps = 21/244 (8%)
Query: 77 RYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVL 136
R H V+ + + + GG N++ A+D+ + +W S R GHS +
Sbjct: 341 RASHKAVVNGNIMWVVGGYMFNHSDYNMVLAYDLASREWLPLNRSVNNVVVRYGHSLALY 400
Query: 137 GKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSH----- 191
+Y++GG +N++ +W L+ K HSA ++
Sbjct: 401 KDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAHIVTLKNGRVV 460
Query: 192 MYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAF--GYNG 249
M V G +G Y + ++ +D W L +G HS+
Sbjct: 461 MLVIFGHCPLYG--------YISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRTR 512
Query: 250 ELYIFGGY---NARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLF 306
LY+ GGY +A R DL++++ + W ++ R IV +++F
Sbjct: 513 ALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILK---DSRFFRYLHTAVIVSGTMLVF 569
Query: 307 GGTS 310
GG +
Sbjct: 570 GGNT 573
>gi|21450861 attractin isoform 1 [Homo sapiens]
Length = 1429
Score = 67.8 bits (164), Expect = 2e-11
Identities = 58/262 (22%), Positives = 108/262 (41%), Gaps = 22/262 (8%)
Query: 13 RRVNHAAVAVGH-------RVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSA 65
R VN+ V GH ++Y +GG T HI N + T + A
Sbjct: 384 RSVNNVVVRYGHSLALYKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYA 443
Query: 66 IRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVP 125
+ G + + ++ G +L+ G G + + +D++ + W G +
Sbjct: 444 VVGHSAHIVTLKNGRVVMLVIF------GHCPLYGYISNVQEYDLDKNTWSILHTQGALV 497
Query: 126 GARDGHSACV--LGKIMYIFGGYEQ-QADCF--SNDIHKLDTSTMTWTLICTKGSPARWR 180
GHS+ + +Y+ GGY+ A+ + ++D+++ D T WT++ +R
Sbjct: 498 QGGYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTIL---KDSRFFR 554
Query: 181 DFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRR 240
H+A ++ M VFGG + + + +D + W P + + R
Sbjct: 555 YLHTAVIVSGTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVNR 614
Query: 241 -SHSAFGYNGELYIFGGYNARL 261
HSA +N +Y+FGG+N+ L
Sbjct: 615 FGHSAVLHNSTMYVFGGFNSLL 636
Score = 47.0 bits (110), Expect = 3e-05
Identities = 51/244 (20%), Positives = 92/244 (37%), Gaps = 21/244 (8%)
Query: 77 RYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVL 136
R H V+ + + + GG N++ A+D+ + +W S R GHS +
Sbjct: 341 RASHKAVVNGNIMWVVGGYMFNHSDYNMVLAYDLASREWLPLNRSVNNVVVRYGHSLALY 400
Query: 137 GKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSH----- 191
+Y++GG +N++ +W L+ K HSA ++
Sbjct: 401 KDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKEQYAVVGHSAHIVTLKNGRVV 460
Query: 192 MYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAF--GYNG 249
M V G +G Y + ++ +D W L +G HS+
Sbjct: 461 MLVIFGHCPLYG--------YISNVQEYDLDKNTWSILHTQGALVQGGYGHSSVYDHRTR 512
Query: 250 ELYIFGGY---NARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLF 306
LY+ GGY +A R DL++++ + W ++ R IV +++F
Sbjct: 513 ALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILK---DSRFFRYLHTAVIVSGTMLVF 569
Query: 307 GGTS 310
GG +
Sbjct: 570 GGNT 573
>gi|62955044 F-box protein 42 [Homo sapiens]
Length = 717
Score = 67.4 bits (163), Expect = 2e-11
Identities = 64/248 (25%), Positives = 100/248 (40%), Gaps = 30/248 (12%)
Query: 77 RYGHSTVLIDDTVLLWGGRNDTEGACNV----LYAFDVNTHKWFTPRVSGTVPGARDGHS 132
R+ HS D ++ T+ +CN L+ D+N+ +W P SG+ P + G +
Sbjct: 119 RFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGAT 178
Query: 133 ACVLGKIMYIFGGYEQ-------QADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSA 185
V ++ +FGG+ + Q + F ++IH S W I T P HS+
Sbjct: 179 LVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAG-HSS 237
Query: 186 TMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLD---CPPTPVLPEGRRSH 242
++ M VFGG G +N+++ V D AW P+P P G +S
Sbjct: 238 CVIDDKMIVFGG---SLGSRQMSNDVW-----VLDLEQWAWSKPNISGPSP-HPRGGQSQ 288
Query: 243 SAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWK----KIEPKGKGPCPRRRQCCCI 298
+ + I GG N F D W + S W K+E + G C
Sbjct: 289 IVID-DATILILGGCGGP-NALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACR 346
Query: 299 VGDKIVLF 306
VG +V+F
Sbjct: 347 VGQCVVVF 354
Score = 59.3 bits (142), Expect = 6e-09
Identities = 53/210 (25%), Positives = 89/210 (42%), Gaps = 7/210 (3%)
Query: 122 GTVPGARDGHSACVL--GKIMYIFGGYEQQA-DCFSNDIHKLDTSTMTWTLICTKGSPAR 178
GT R HSAC + MY+FGG Q + + ND+ +LD ++ W GS
Sbjct: 113 GTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPS 172
Query: 179 WRDFHSATMLGSHMYVFGGRADRFGPFHSNN-EIYCNRIRVFDTRTEAWLDCPPTPVLPE 237
+ + + + +FGG R P+ + E + + I + ++ W +C T P
Sbjct: 173 PKAGATLVVYKDLLVLFGGWT-RPSPYPLHQPERFFDEIHTYSP-SKNWWNCIVTTHGPP 230
Query: 238 GRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCC 297
HS+ + ++ +FGG + + +D+W + + W K G P PR Q
Sbjct: 231 PMAGHSSCVIDDKMIVFGG-SLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQI 289
Query: 298 IVGDKIVLFGGTSPSPEEGLGDEFDLIDHS 327
++ D +L G P D + L HS
Sbjct: 290 VIDDATILILGGCGGPNALFKDAWLLHMHS 319
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/88 (38%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 230 PPTPVLPEGRRSHSAFGY--NGELYIFGGYN-ARLNRHFHDLWKFNPVSFTWKKIEPKGK 286
P TP+ R SHSA Y N +Y+FGG + N F+DLW+ + S W + G
Sbjct: 112 PGTPITQ--RFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGS 169
Query: 287 GPCPRRRQCCCIVGDKIVLFGG-TSPSP 313
P P+ + D +VLFGG T PSP
Sbjct: 170 YPSPKAGATLVVYKDLLVLFGGWTRPSP 197
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 61.6 bits (148), Expect = 1e-09
Identities = 55/236 (23%), Positives = 91/236 (38%), Gaps = 28/236 (11%)
Query: 77 RYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVL 136
R +ID+ + + GGR+ + N + F+ W V + R G L
Sbjct: 466 RLQFGVAVIDNKLYVVGGRDGLK-TLNTVECFNPVGKIW---TVMPPMSTHRHGLGVATL 521
Query: 137 GKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFG 196
MY GG++ + + N + + D W + + +P R L + +Y G
Sbjct: 522 EGPMYAVGGHDGWS--YLNTVERWDPEGRQWNYVASMSTP---RSTVGVVALNNKLYAIG 576
Query: 197 GRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGG 256
GR + + FD T W C P + + R YNG LY+ GG
Sbjct: 577 GR---------DGSSCLKSMEYFDPHTNKWSLCAP---MSKRRGGVGVATYNGFLYVVGG 624
Query: 257 YNARLNRHFHDL----WKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGG 308
++A + H L +++P +W + P PR C +GDK+ + GG
Sbjct: 625 HDAPASNHCSRLSDCVERYDPKGDSWSTVAPLS---VPRDAVAVCPLGDKLYVVGG 677
Score = 44.7 bits (104), Expect = 1e-04
Identities = 54/256 (21%), Positives = 93/256 (36%), Gaps = 65/256 (25%)
Query: 13 RRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRG---- 68
RR+ + +++Y GG + +TL ++ FN V WT +PP+ + G
Sbjct: 465 RRLQFGVAVIDNKLYVVGGR---DGLKTLNTVEC--FNPVGKIWTVMPPMSTHRHGLGVA 519
Query: 69 --QAPVVPYMRYGHSTVLIDDTVLLW--------------------------------GG 94
+ P+ Y GH +TV W GG
Sbjct: 520 TLEGPM--YAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGG 577
Query: 95 RNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQAD--C 152
R+ + ++ Y FD +T+KW + + R G +Y+ GG++ A C
Sbjct: 578 RDGSSCLKSMEY-FDPHTNKW---SLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
Query: 153 --FSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNE 210
S+ + + D +W+ + P RD + LG +YV GG +
Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVP---RDAVAVCPLGDKLYVVGG---------YDGH 681
Query: 211 IYCNRIRVFDTRTEAW 226
Y N + +D + W
Sbjct: 682 TYLNTVESYDAQRNEW 697
Score = 33.1 bits (74), Expect = 0.43
Identities = 36/170 (21%), Positives = 60/170 (35%), Gaps = 26/170 (15%)
Query: 3 RWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPV 62
+W R VA+ +++Y+ GG +++ D H + +W+ P+
Sbjct: 549 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPH-----TNKWSLCAPM 603
Query: 63 KSAIRGQAPVVPYMRY-----GHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFT 117
S RG V Y + GH N + + +D W T
Sbjct: 604 -SKRRGGVGVATYNGFLYVVGGHDAP----------ASNHCSRLSDCVERYDPKGDSWST 652
Query: 118 PRVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTW 167
+VP RD + C LG +Y+ GGY+ + N + D W
Sbjct: 653 VAPL-SVP--RDAVAVCPLGDKLYVVGGYD--GHTYLNTVESYDAQRNEW 697
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 61.6 bits (148), Expect = 1e-09
Identities = 55/236 (23%), Positives = 91/236 (38%), Gaps = 28/236 (11%)
Query: 77 RYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVL 136
R +ID+ + + GGR+ + N + F+ W V + R G L
Sbjct: 466 RLQFGVAVIDNKLYVVGGRDGLK-TLNTVECFNPVGKIW---TVMPPMSTHRHGLGVATL 521
Query: 137 GKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFG 196
MY GG++ + + N + + D W + + +P R L + +Y G
Sbjct: 522 EGPMYAVGGHDGWS--YLNTVERWDPEGRQWNYVASMSTP---RSTVGVVALNNKLYAIG 576
Query: 197 GRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGG 256
GR + + FD T W C P + + R YNG LY+ GG
Sbjct: 577 GR---------DGSSCLKSMEYFDPHTNKWSLCAP---MSKRRGGVGVATYNGFLYVVGG 624
Query: 257 YNARLNRHFHDL----WKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGG 308
++A + H L +++P +W + P PR C +GDK+ + GG
Sbjct: 625 HDAPASNHCSRLSDCVERYDPKGDSWSTVAPLS---VPRDAVAVCPLGDKLYVVGG 677
Score = 45.4 bits (106), Expect = 8e-05
Identities = 55/264 (20%), Positives = 96/264 (36%), Gaps = 65/264 (24%)
Query: 13 RRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRG---- 68
RR+ + +++Y GG + +TL ++ FN V WT +PP+ + G
Sbjct: 465 RRLQFGVAVIDNKLYVVGGR---DGLKTLNTVEC--FNPVGKIWTVMPPMSTHRHGLGVA 519
Query: 69 --QAPVVPYMRYGHSTVLIDDTVLLW--------------------------------GG 94
+ P+ Y GH +TV W GG
Sbjct: 520 TLEGPM--YAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGG 577
Query: 95 RNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQAD--C 152
R+ + ++ Y FD +T+KW + + R G +Y+ GG++ A C
Sbjct: 578 RDGSSCLKSMEY-FDPHTNKW---SLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
Query: 153 --FSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNE 210
S+ + + D +W+ + P RD + LG +YV GG +
Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVP---RDAVAVCPLGDKLYVVGG---------YDGH 681
Query: 211 IYCNRIRVFDTRTEAWLDCPPTPV 234
Y N + +D + W + P +
Sbjct: 682 TYLNTVESYDAQRNEWKEEVPVNI 705
Score = 33.1 bits (74), Expect = 0.43
Identities = 36/170 (21%), Positives = 60/170 (35%), Gaps = 26/170 (15%)
Query: 3 RWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPV 62
+W R VA+ +++Y+ GG +++ D H + +W+ P+
Sbjct: 549 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPH-----TNKWSLCAPM 603
Query: 63 KSAIRGQAPVVPYMRY-----GHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFT 117
S RG V Y + GH N + + +D W T
Sbjct: 604 -SKRRGGVGVATYNGFLYVVGGHDAP----------ASNHCSRLSDCVERYDPKGDSWST 652
Query: 118 PRVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTW 167
+VP RD + C LG +Y+ GGY+ + N + D W
Sbjct: 653 VAPL-SVP--RDAVAVCPLGDKLYVVGGYD--GHTYLNTVESYDAQRNEW 697
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 58.2 bits (139), Expect = 1e-08
Identities = 62/288 (21%), Positives = 112/288 (38%), Gaps = 45/288 (15%)
Query: 14 RVNHAAVAVGHRVYSFGGYCSGEDYETLRQID-VHIFNAVSLRWTKLPPVKSAIRGQAPV 72
R ++ +G +Y GGY + + + +D V I+N+ S WT+ P+ +A
Sbjct: 310 RESYGVTCLGPNIYVTGGYRT----DNIEALDTVWIYNSESDEWTEGLPMLNA------- 358
Query: 73 VPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHS 132
RY H V + V GG A + +D KW ++ + G + +
Sbjct: 359 ----RYYHCAVTLGGCVYALGGYRKGAPAEEAEF-YDPLKEKWIP--IANMIKGVGNA-T 410
Query: 133 ACVLGKIMYIFGGY-EQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSH 191
ACVL ++Y+ GG+ + C + + ++ W+LI + P + +
Sbjct: 411 ACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGL---CSVPFENK 467
Query: 192 MYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGEL 251
+Y+ GG+ +D W + P + E R A NG +
Sbjct: 468 LYLVGGQT--------------TITECYDPEQNEWREIAP---MMERRMECGAVIMNGCI 510
Query: 252 YIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQ-CCCI 298
Y+ GGY+ + + K++P W+ + G P R C C+
Sbjct: 511 YVTGGYSYSKGTYLQSIEKYDPDLNKWEIV---GNLPSAMRSHGCVCV 555
Score = 40.0 bits (92), Expect = 0.004
Identities = 43/201 (21%), Positives = 72/201 (35%), Gaps = 43/201 (21%)
Query: 4 WTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSG------EDYETLRQIDVHIFNAV----- 52
WT L R H AV +G VY+ GGY G E Y+ L++ + I N +
Sbjct: 349 WTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGN 408
Query: 53 ---------------------SLRWTKLPPVKSAIRGQAPVV--PYMRYGHSTVLIDDTV 89
S + K+ S I + + P+ YG +V ++ +
Sbjct: 409 ATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKL 468
Query: 90 LLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQ 149
L GG+ + +D ++W R + R A ++ +Y+ GGY
Sbjct: 469 YLVGGQT------TITECYDPEQNEW---REIAPMMERRMECGAVIMNGCIYVTGGYSYS 519
Query: 150 ADCFSNDIHKLDTSTMTWTLI 170
+ I K D W ++
Sbjct: 520 KGTYLQSIEKYDPDLNKWEIV 540
>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
Length = 2778
Score = 56.2 bits (134), Expect = 5e-08
Identities = 72/271 (26%), Positives = 106/271 (39%), Gaps = 38/271 (14%)
Query: 14 RVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSL-RWTKLPPVKSAIRGQAPV 72
R +H AVA + GG + DV F+ + W L P S+ G +
Sbjct: 279 RHSHVAVAWAGSLVLMGGELADGSLTN----DVWAFSPLGRGHWELLAPPASSSSGPPGL 334
Query: 73 VPYMRYGHSTVLIDDTVL-LWGGRNDTEGACNVLYAFDVNTHK---WFTPRVSGTVPGAR 128
GH+ L+DD L + GGR + + L+ F +++ W +G P A
Sbjct: 335 A-----GHAAALVDDVWLYVSGGRTPHDLFSSGLFRFRLDSTSGGYWEQVIPAGGRPPAA 389
Query: 129 DGHSAC--VLGKIMYIFGGYEQQADCFS---NDIHKLDTSTMTWTLICTKGSPA----RW 179
GHS + + + GG+ FS N WT + KG R
Sbjct: 390 TGHSMVFHAPSRALLVHGGHRPSTARFSVRVNSTELFHVDRHVWTTL--KGRDGLQGPRE 447
Query: 180 RDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAW-----LDCPPTP- 233
R FH+A++LG++M V+GG + + Y + I + W L P TP
Sbjct: 448 RAFHTASVLGNYMVVYGGNVH---THYQEEKCYEDGIFFYHLGCHQWVSGAELAPPGTPE 504
Query: 234 ---VLPEGRRSHSAFGYNGE-LYIFGGYNAR 260
P GR SH A G L + GGY+ R
Sbjct: 505 GRAAPPSGRYSHVAAVLGGSVLLVAGGYSGR 535
Score = 48.1 bits (113), Expect = 1e-05
Identities = 79/330 (23%), Positives = 116/330 (35%), Gaps = 93/330 (28%)
Query: 3 RWTVHLEGG--------PRRVNHAAVAVGHR--VYSFGGYCSGEDYETLRQIDVHIFNAV 52
RWT L G PR + AA R +Y GG +G D + N
Sbjct: 1481 RWTQMLAGAEDGGPGPSPRSFHAAAYVPAGRGAMYLLGGLTAGGVTR-----DFWVLNLT 1535
Query: 53 SLRWTKLPPVKSAIRGQAPVVPYMRYGHS-TVLIDDTVLLWGGRNDTEGACNVLYAFDVN 111
+L+W + K+ + P V GH+ T ++LL GG + G L + +
Sbjct: 1536 TLQWRQ---EKAPQTVELPAVA----GHTLTARRGLSLLLVGGYSPENGFNQQLLEYQLA 1588
Query: 112 THKWFTPRVSGTVPGARDGHSACV--LGKIMYIFGGYEQQADCF--SNDIHKLDTSTMTW 167
T W + SGT P GHSA +Y+FGG+ + S +++ L TW
Sbjct: 1589 TGTWVSGAQSGTPPTGLYGHSAVYHEATDSLYVFGGFRFHVELAAPSPELYSLHCPDRTW 1648
Query: 168 TLIC------------TKGS-----------PARW------------------------- 179
+L+ +GS P W
Sbjct: 1649 SLLAPSQGAKRDRMRNVRGSSRGLGQVPGEQPGSWGFREVRKKMALWAALAGTGGFLEEI 1708
Query: 180 ---------RDFHSATMLGSHMYVFGGRADRFGPFHSNNEIY---CNRIRVFDTRTEAWL 227
R FH++ +LG M V GGR+D F S+ +Y CN + D A +
Sbjct: 1709 SPHLKEPRPRLFHASALLGDTMVVLGGRSDP-DEFSSDVLLYQVNCNAWLLPDLTRSASV 1767
Query: 228 DCPPTPVLPEGRRSHSAFGYNGELYIFGGY 257
P E +H+ LYI GG+
Sbjct: 1768 GPP-----MEESVAHAVAAVGSRLYISGGF 1792
Score = 39.7 bits (91), Expect = 0.005
Identities = 55/224 (24%), Positives = 90/224 (40%), Gaps = 30/224 (13%)
Query: 77 RYGHSTVLIDDTVL-LWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTV-----PGARDG 130
R GH+ V D L ++GG +G LY + V+ +W T ++G P R
Sbjct: 1443 RLGHTMVDGPDATLWMFGGLGLPQGLLGNLYRYSVSERRW-TQMLAGAEDGGPGPSPRSF 1501
Query: 131 HSACVLGK---IMYIFGGYEQQADCFSNDIHKLDTSTMTW---TLICTKGSPARWRDFHS 184
H+A + MY+ GG A + D L+ +T+ W T PA H+
Sbjct: 1502 HAAAYVPAGRGAMYLLGGL--TAGGVTRDFWVLNLTTLQWRQEKAPQTVELPA--VAGHT 1557
Query: 185 AT-MLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHS 243
T G + + GG + P + N+ ++ + T W+ + P G HS
Sbjct: 1558 LTARRGLSLLLVGG----YSPENGFNQ----QLLEYQLATGTWVSGAQSGTPPTGLYGHS 1609
Query: 244 AFGYNG--ELYIFGG--YNARLNRHFHDLWKFNPVSFTWKKIEP 283
A + LY+FGG ++ L +L+ + TW + P
Sbjct: 1610 AVYHEATDSLYVFGGFRFHVELAAPSPELYSLHCPDRTWSLLAP 1653
Score = 31.2 bits (69), Expect = 1.6
Identities = 33/116 (28%), Positives = 48/116 (41%), Gaps = 11/116 (9%)
Query: 202 FGPFHSNNEIYCNRIRVFDTRT-EAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNAR 260
FG NN + + F T E+W D P P R SH A + G L + GG A
Sbjct: 245 FGGQDLNNALGDLVLYNFSANTWESW-DLSPAPA---ARHSHVAVAWAGSLVLMGGELAD 300
Query: 261 LNRHFHDLWKFNPVS-FTWKKIEP---KGKGPCPRRRQCCCIVGDK-IVLFGGTSP 311
+D+W F+P+ W+ + P GP +V D + + GG +P
Sbjct: 301 -GSLTNDVWAFSPLGRGHWELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTP 355
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 54.7 bits (130), Expect = 1e-07
Identities = 51/192 (26%), Positives = 74/192 (38%), Gaps = 25/192 (13%)
Query: 92 WGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQAD 151
W G + T N + A+D +W P A H A L +YI GG++ D
Sbjct: 299 WSGGSPT----NAIEAYDARADRWVNVTCEEESPRAY--HGAAYLKGYVYIIGGFDS-VD 351
Query: 152 CFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEI 211
F N + + D TW + S R + S T+LG+ +Y GG + +
Sbjct: 352 YF-NSVKRFDPVKKTWHQVAPMHSR---RCYVSVTVLGNFIYAMGG---------FDGYV 398
Query: 212 YCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKF 271
N ++ T W P + E R SA G++YI GG+N N +
Sbjct: 399 RLNTAERYEPETNQWTLIAP---MHEQRSDASATTLYGKVYICGGFNG--NECLFTAEVY 453
Query: 272 NPVSFTWKKIEP 283
N S W I P
Sbjct: 454 NTESNQWTVIAP 465
Score = 41.2 bits (95), Expect = 0.002
Identities = 26/95 (27%), Positives = 44/95 (46%), Gaps = 7/95 (7%)
Query: 214 NRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNP 273
N I +D R + W++ P R H A G +YI GG+++ +F+ + +F+P
Sbjct: 306 NAIEAYDARADRWVNVTCEEESP--RAYHGAAYLKGYVYIIGGFDSV--DYFNSVKRFDP 361
Query: 274 VSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGG 308
V TW ++ P C ++G+ I GG
Sbjct: 362 VKKTWHQVAPMHSRRC---YVSVTVLGNFIYAMGG 393
Score = 38.5 bits (88), Expect = 0.010
Identities = 44/189 (23%), Positives = 77/189 (40%), Gaps = 26/189 (13%)
Query: 9 EGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRG 68
E PR + AA G+ VY GG+ S + + ++++ F+ V W ++ P+ S
Sbjct: 325 EESPRAYHGAAYLKGY-VYIIGGFDSVDYFNSVKR-----FDPVKKTWHQVAPMHS---- 374
Query: 69 QAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGAR 128
R S ++ + + GG D N ++ T++W + + R
Sbjct: 375 -------RRCYVSVTVLGNFIYAMGG-FDGYVRLNTAERYEPETNQW---TLIAPMHEQR 423
Query: 129 DGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATML 188
SA L +YI GG+ F+ +++ +T + WT+I S R
Sbjct: 424 SDASATTLYGKVYICGGFNGNECLFTAEVY--NTESNQWTVIAPMRSR---RSGIGVIAY 478
Query: 189 GSHMYVFGG 197
G H+Y GG
Sbjct: 479 GEHVYAVGG 487
Score = 36.2 bits (82), Expect = 0.051
Identities = 35/147 (23%), Positives = 61/147 (41%), Gaps = 22/147 (14%)
Query: 139 IMYIFGGYEQQADCFSNDIHKLDTSTMTWTLI-CTKGSPARWRDFHSATMLGSHMYVFGG 197
I++ GG+ + +N I D W + C + SP R +H A L ++Y+ GG
Sbjct: 292 ILFAIGGWSGGSP--TNAIEAYDARADRWVNVTCEEESP---RAYHGAAYLKGYVYIIGG 346
Query: 198 RADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGE-LYIFGG 256
F S + Y N ++ FD + W P RR + + G +Y GG
Sbjct: 347 -------FDSVD--YFNSVKRFDPVKKTWHQVAPM----HSRRCYVSVTVLGNFIYAMGG 393
Query: 257 YNARLNRHFHDLWKFNPVSFTWKKIEP 283
++ + + + ++ P + W I P
Sbjct: 394 FDGYVRLNTAE--RYEPETNQWTLIAP 418
Score = 33.1 bits (74), Expect = 0.43
Identities = 28/114 (24%), Positives = 48/114 (42%), Gaps = 17/114 (14%)
Query: 3 RWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPV 62
+WTV RR +A G VY+ GG+ + LR + ++ V+ W +P +
Sbjct: 459 QWTVIAPMRSRRSGIGVIAYGEHVYAVGGF---DGANRLRSAEA--YSPVANTWRTIPTM 513
Query: 63 KSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWF 116
+ P +G ++DD + + GG N NV +D T +W+
Sbjct: 514 FN---------PRSNFG--IEVVDDLLFVVGGFNGFTTTFNV-ECYDEKTDEWY 555
>gi|158508542 kelch-like 33 [Homo sapiens]
Length = 453
Score = 53.5 bits (127), Expect = 3e-07
Identities = 72/305 (23%), Positives = 112/305 (36%), Gaps = 36/305 (11%)
Query: 12 PRRVNHAAVAV-GHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQA 70
P R H A ++ G +Y GG TL A +LRW P + A
Sbjct: 179 PGRFRHGAASLAGSELYVCGGQDFYSHSNTL---------ASTLRWE---PSQEDWEEMA 226
Query: 71 PVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDG 130
P+ R S V +D + GGR++ + A + + ++ + W R + +P
Sbjct: 227 PL-SQARSLFSLVALDGKLYALGGRHN-DVALDSVETYNPELNVW---RPAPALPAPCFA 281
Query: 131 HSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGS 190
H+A +L +Y+ GG ++ +H T + G P R H LG
Sbjct: 282 HAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVP---RAGHVMAALGG 338
Query: 191 HMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGE 250
+YV GG + ++ RT++W P P G S GE
Sbjct: 339 RLYVAGGLGETEDLLS---------FEAYELRTDSWTHLAPLPSPHVGAASAVL---QGE 386
Query: 251 LYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTS 310
L + GGY+ R H + + P W + G P PR CI+ V
Sbjct: 387 LLVLGGYSHRTYALSHLIHAYCPGLGRWLCL---GTLPRPRAEMPACILTLPAVQHIALV 443
Query: 311 PSPEE 315
P+P +
Sbjct: 444 PTPHQ 448
Score = 40.4 bits (93), Expect = 0.003
Identities = 53/237 (22%), Positives = 89/237 (37%), Gaps = 38/237 (16%)
Query: 125 PGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARW----- 179
PG +A + G +Y+ GG Q SN + ST+ W + S W
Sbjct: 179 PGRFRHGAASLAGSELYVCGG--QDFYSHSNTL----ASTLRW-----EPSQEDWEEMAP 227
Query: 180 ----RDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVL 235
R S L +Y GGR +N++ + + ++ W P P L
Sbjct: 228 LSQARSLFSLVALDGKLYALGGR---------HNDVALDSVETYNPELNVWR---PAPAL 275
Query: 236 PEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNP-VSFTWKKIEPKGKGPCPRRRQ 294
P +H+A G+LY+ GG ++ L ++P + + P G PR
Sbjct: 276 PAPCFAHAAAILEGQLYVSGGCGG-TGQYLASLMHYDPKLEKPGTFLSPMG---VPRAGH 331
Query: 295 CCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNL 351
+G ++ + GG + + + ++L S H+ PS AV+Q L
Sbjct: 332 VMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPL-PSPHVGAASAVLQGEL 387
Score = 39.7 bits (91), Expect = 0.005
Identities = 37/129 (28%), Positives = 53/129 (41%), Gaps = 24/129 (18%)
Query: 11 GPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLR---WTKLPPVKSAIR 67
G R H A+G R+Y GG ED + F A LR WT L P+ S
Sbjct: 325 GVPRAGHVMAALGGRLYVAGGLGETEDLLS--------FEAYELRTDSWTHLAPLPSPHV 376
Query: 68 GQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGA 127
G A S VL + ++L G + T ++++A+ +W GT+P
Sbjct: 377 GAA----------SAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRWL---CLGTLPRP 423
Query: 128 RDGHSACVL 136
R AC+L
Sbjct: 424 RAEMPACIL 432
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 53.5 bits (127), Expect = 3e-07
Identities = 56/256 (21%), Positives = 96/256 (37%), Gaps = 24/256 (9%)
Query: 3 RWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPV 62
+W RR +H +G ++ GG S ++ ++ ++ +W +
Sbjct: 324 QWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQW-----I 378
Query: 63 KSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSG 122
K A Q V Y+ I+D ++ GGRN+ GA + + + T W V+G
Sbjct: 379 KVASMNQRRVDFYL------ASIEDMLVAIGGRNEN-GALSSVETYSPKTDSW--SYVAG 429
Query: 123 TVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDF 182
+P GH+ + +YI GG++ Q + ++ D T W + R +
Sbjct: 430 -LPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWE---ERRPMTTARGW 485
Query: 183 HSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSH 242
HS LG +Y GG D S + + + W P L
Sbjct: 486 HSMCSLGDSIYSIGGSDDNI---ESMERFDVLGVEAYSPQCNQWTRVAP---LLHANSES 539
Query: 243 SAFGYNGELYIFGGYN 258
+ G +YI GGY+
Sbjct: 540 GVAVWEGRIYILGGYS 555
Score = 49.3 bits (116), Expect = 6e-06
Identities = 55/247 (22%), Positives = 94/247 (38%), Gaps = 37/247 (14%)
Query: 45 DVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGR----NDTEG 100
D +A S +W K P+ P R H ++ + + GG N +
Sbjct: 314 DTCYLDAKSEQWVKETPL-----------PARRSHHCVAVLGGFIFIAGGSFSRDNGGDA 362
Query: 101 ACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKL 160
A N+LY +D +W +V+ D + A + ++ I G E A + +
Sbjct: 363 ASNLLYRYDPRCKQWI--KVASMNQRRVDFYLASIEDMLVAIGGRNENGA---LSSVETY 417
Query: 161 DTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFD 220
T +W+ + G P R+ H+ T+ +Y+ GG + GP+ N + +D
Sbjct: 418 SPKTDSWSYVA--GLP-RFTYGHAGTIYKDFVYISGGHDYQIGPYRKN-------LLCYD 467
Query: 221 TRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGY--NARLNRHFHDLW--KFNPVSF 276
RT+ W + P + R HS +Y GG N F L ++P
Sbjct: 468 HRTDVWEERRP---MTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCN 524
Query: 277 TWKKIEP 283
W ++ P
Sbjct: 525 QWTRVAP 531
Score = 41.6 bits (96), Expect = 0.001
Identities = 37/159 (23%), Positives = 58/159 (36%), Gaps = 18/159 (11%)
Query: 73 VPYMRYGHSTVLIDDTVLLWGGRNDTEGACNV-LYAFDVNTHKWFTPRVSGTVPGARDGH 131
+P YGH+ + D V + GG + G L +D T W R T AR H
Sbjct: 430 LPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTT---ARGWH 486
Query: 132 SACVLGKIMYIFGGYEQQADCFSN----DIHKLDTSTMTWTLICTKGSPARWRDFHSATM 187
S C LG +Y GG + + + WT + H+ +
Sbjct: 487 SMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPL--------LHANSE 538
Query: 188 LGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAW 226
G + V+ GR G + N + ++V+D + W
Sbjct: 539 SG--VAVWEGRIYILGGYSWENTAFSKTVQVYDREADKW 575
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 53.5 bits (127), Expect = 3e-07
Identities = 54/240 (22%), Positives = 89/240 (37%), Gaps = 28/240 (11%)
Query: 74 PYMRYGHSTVLIDDT--VLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGH 131
P M+ + + D T V L G L +D +W R + R H
Sbjct: 284 PVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQEW---RSLAPMDAPRYQH 340
Query: 132 SACVLGKIMYIFGG---YEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATML 188
V+G +Y+ GG Y+ + + + + D W + + R F + L
Sbjct: 341 GIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEK---RTFFHLSAL 397
Query: 189 GSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYN 248
H+Y GGR+ + E+ + ++ R W + E H+ Y
Sbjct: 398 KGHLYAVGGRS-------AAGELAT--VECYNPRMNEW---SYVAKMSEPHYGHAGTVYG 445
Query: 249 GELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGG 308
G +YI GG + ++L F+P + W + P R C C VGDK+ + GG
Sbjct: 446 GLMYISGGITH--DTFQNELMCFDPDTDKWMQKAPM---TTVRGLHCMCTVGDKLYVIGG 500
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 52.4 bits (124), Expect = 7e-07
Identities = 52/222 (23%), Positives = 92/222 (41%), Gaps = 19/222 (8%)
Query: 88 TVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYE 147
T+L+ GG+ C+ +Y D HK +P R SA +G +Y+ GG
Sbjct: 296 TLLILGGQTFM---CDKIYQVD---HKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRG 349
Query: 148 QQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDF-HSATMLGSHMYVFGGRADRFGPFH 206
+ + S D+ DT W+ K +P F H + L + +YV GG G F
Sbjct: 350 SE-NGVSKDVWVYDTVHEEWS----KAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFP 404
Query: 207 SNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNARLNRHFH 266
++ + ++ +D W+ P L +G + + +L++FGG + +
Sbjct: 405 ASPSVSLKQVEKYDPGANKWMMVAP---LRDGVSNAAVVSAKLKLFVFGGTSIHRDM-VS 460
Query: 267 DLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGG 308
+ ++P W K + P P R ++G +I + GG
Sbjct: 461 KVQCYDPSENRW---TIKAECPQPWRYTAAAVLGSQIFIMGG 499
Score = 38.9 bits (89), Expect = 0.008
Identities = 53/261 (20%), Positives = 81/261 (31%), Gaps = 70/261 (26%)
Query: 73 VPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHS 132
+P R S I V + GGR G ++ +D +W + + AR GH
Sbjct: 326 LPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEW---SKAAPMLIARFGHG 382
Query: 133 ACVLGKIMYIFGGYEQQADCFS-------NDIHKLDTSTMTWTLI--------------- 170
+ L +Y+ GG+ A F + K D W ++
Sbjct: 383 SAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSA 442
Query: 171 ---------------------CTKGSPARWR---------DFHSATMLGSHMYVFGGRAD 200
C S RW + +A +LGS +++ GG
Sbjct: 443 KLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG--- 499
Query: 201 RFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGYNAR 260
+ E FD T W + R S A +LY+ GGY
Sbjct: 500 -------DTEFTAASAYRFDCETNQWTRIGD---MTAKRMSCHALASGNKLYVVGGYFG- 548
Query: 261 LNRHFHDLWKFNPVSFTWKKI 281
+ L ++P S TW I
Sbjct: 549 -TQRCKTLDCYDPTSDTWNCI 568
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 52.4 bits (124), Expect = 7e-07
Identities = 59/276 (21%), Positives = 103/276 (37%), Gaps = 37/276 (13%)
Query: 3 RWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPV 62
RW E RR V + VY+ GG+ +LR V +++ V +WT + +
Sbjct: 326 RWDQIAELPSRRCRAGVVFMAGHVYAVGGFNG-----SLRVRTVDVYDGVKDQWTSIASM 380
Query: 63 KSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSG 122
+ R +++D + GG + + G +V A+ T++WF
Sbjct: 381 QER-----------RSTLGAAVLNDLLYAVGGFDGSTGLASV-EAYSYKTNEWFFVAPMN 428
Query: 123 TVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDF 182
T R V+ +Y GGY+ + + + + + +T W + + R
Sbjct: 429 T---RRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTR---RSG 482
Query: 183 HSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSH 242
+L +Y GG GP + + V+D T W + RR+
Sbjct: 483 AGVGVLSGQLYATGGHD---GPLVRKS------VEVYDPGTNTWKQVADMNMC---RRNA 530
Query: 243 SAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTW 278
NG LY+ GG + N + +NPV+ W
Sbjct: 531 GVCAVNGLLYVVGGDDGSCN--LASVEYYNPVTDKW 564
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 51.2 bits (121), Expect = 2e-06
Identities = 52/240 (21%), Positives = 87/240 (36%), Gaps = 28/240 (11%)
Query: 74 PYMRYGHSTVLIDDT--VLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGH 131
P M+ + + D T V L G L +D H+W + + R H
Sbjct: 326 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEW---KSLAPMDAPRYQH 382
Query: 132 SACVLGKIMYIFGG---YEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATML 188
V+G +Y+ GG Y+ + + + + D W + + R F + L
Sbjct: 383 GIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEK---RTFFHLSAL 439
Query: 189 GSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYN 248
++Y GGR N + ++ RT W + E H+ Y
Sbjct: 440 KGYLYAVGGR---------NAAGELPTVECYNPRTNEWTYVAK---MSEPHYGHAGTVYG 487
Query: 249 GELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGG 308
G +YI GG + +L F+P + W + P R C C VG+++ + GG
Sbjct: 488 GVMYISGGITH--DTFQKELMCFDPDTDKWIQKAPM---TTVRGLHCMCTVGERLYVIGG 542
Score = 50.8 bits (120), Expect = 2e-06
Identities = 59/269 (21%), Positives = 100/269 (37%), Gaps = 29/269 (10%)
Query: 14 RVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVV 73
R H +G+ +Y GG +Y+T + V R+ K V S +
Sbjct: 379 RYQHGIAVIGNFLYVVGGQ---SNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRT--- 432
Query: 74 PYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKW-FTPRVSGTVPGARDGHS 132
+ H + L + GGRN G + ++ T++W + ++S GH+
Sbjct: 433 ----FFHLSAL-KGYLYAVGGRN-AAGELPTVECYNPRTNEWTYVAKMSEP----HYGHA 482
Query: 133 ACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHM 192
V G +MYI GG D F ++ D T W K R H +G +
Sbjct: 483 GTVYGGVMYISGGITH--DTFQKELMCFDPDTDKW---IQKAPMTTVRGLHCMCTVGERL 537
Query: 193 YVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELY 252
YV GG R G ++ + C + + W P + G+ + ++Y
Sbjct: 538 YVIGGNHFR-GTSDYDDVLSC---EYYSPILDQW---TPIAAMLRGQSDVGVAVFENKIY 590
Query: 253 IFGGYNARLNRHFHDLWKFNPVSFTWKKI 281
+ GGY+ + K++P W K+
Sbjct: 591 VVGGYSWNNRCMVEIVQKYDPDKDEWHKV 619
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/279 (21%), Positives = 107/279 (38%), Gaps = 43/279 (15%)
Query: 3 RWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPV 62
RW E RR V + V++ GG+ +LR V ++ V +WT
Sbjct: 244 RWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG-----SLRVRTVDSYDPVKDQWTS---- 294
Query: 63 KSAIRGQAPVVPYMRYGHSTV---LIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPR 119
V MR ST+ +++ + GG + + G +V A+++ +++WF
Sbjct: 295 ----------VANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSV-EAYNIKSNEWFHVA 343
Query: 120 VSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARW 179
T R V+G ++Y GGY+ + + + + +T WT I +
Sbjct: 344 PMNT---RRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTR--- 397
Query: 180 RDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGR 239
R +L + +Y GG + + + V+D T AW + R
Sbjct: 398 RSGAGVGVLNNLLYAVGGH---------DGPLVRKSVEVYDPTTNAWRQVADMNMC---R 445
Query: 240 RSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTW 278
R+ NG LY+ GG + N + +NP + W
Sbjct: 446 RNAGVCAVNGLLYVVGGDDGSCN--LASVEYYNPTTDKW 482
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/279 (21%), Positives = 107/279 (38%), Gaps = 43/279 (15%)
Query: 3 RWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPV 62
RW E RR V + V++ GG+ +LR V ++ V +WT
Sbjct: 336 RWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG-----SLRVRTVDSYDPVKDQWTS---- 386
Query: 63 KSAIRGQAPVVPYMRYGHSTV---LIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPR 119
V MR ST+ +++ + GG + + G +V A+++ +++WF
Sbjct: 387 ----------VANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSV-EAYNIKSNEWFHVA 435
Query: 120 VSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARW 179
T R V+G ++Y GGY+ + + + + +T WT I +
Sbjct: 436 PMNT---RRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTR--- 489
Query: 180 RDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGR 239
R +L + +Y GG + + + V+D T AW + R
Sbjct: 490 RSGAGVGVLNNLLYAVGGH---------DGPLVRKSVEVYDPTTNAWRQVADMNMC---R 537
Query: 240 RSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTW 278
R+ NG LY+ GG + N + +NP + W
Sbjct: 538 RNAGVCAVNGLLYVVGGDDGSCN--LASVEYYNPTTDKW 574
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 50.8 bits (120), Expect = 2e-06
Identities = 61/279 (21%), Positives = 107/279 (38%), Gaps = 43/279 (15%)
Query: 3 RWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPV 62
RW E RR V + V++ GG+ +LR V ++ V +WT
Sbjct: 332 RWHQVAELPSRRCRAGMVYMAGLVFAVGGFNG-----SLRVRTVDSYDPVKDQWTS---- 382
Query: 63 KSAIRGQAPVVPYMRYGHSTV---LIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPR 119
V MR ST+ +++ + GG + + G +V A+++ +++WF
Sbjct: 383 ----------VANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSV-EAYNIKSNEWFHVA 431
Query: 120 VSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARW 179
T R V+G ++Y GGY+ + + + + +T WT I +
Sbjct: 432 PMNT---RRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTR--- 485
Query: 180 RDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGR 239
R +L + +Y GG + + + V+D T AW + R
Sbjct: 486 RSGAGVGVLNNLLYAVGGH---------DGPLVRKSVEVYDPTTNAWRQVADMNMC---R 533
Query: 240 RSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTW 278
R+ NG LY+ GG + N + +NP + W
Sbjct: 534 RNAGVCAVNGLLYVVGGDDGSCN--LASVEYYNPTTDKW 570
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 50.1 bits (118), Expect = 3e-06
Identities = 57/272 (20%), Positives = 103/272 (37%), Gaps = 36/272 (13%)
Query: 18 AAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMR 77
A+V++ R+Y GGY ++ +D W + P+ + RG A
Sbjct: 323 ASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGV--WYSVAPM-NVRRGLA------- 372
Query: 78 YGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVPGARDGHSACVLG 137
+ D + + GG + + + + +D N +W + G + AR+G V
Sbjct: 373 ---GATTLGDMIYVSGGFDGSRRHTS-MERYDPNIDQW---SMLGDMQTAREGAGLVVAS 425
Query: 138 KIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGG 197
++Y GGY+ N + K D T WT + A R +L H+YV GG
Sbjct: 426 GVIYCLGGYDGLN--ILNSVEKYDPHTGHWTNVTPM---ATKRSGAGVALLNDHIYVVGG 480
Query: 198 RADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIFGGY 257
+ + + + ++ RT++W + R A G LY GY
Sbjct: 481 ---------FDGTAHLSSVEAYNIRTDSW---TTVTSMTTPRCYVGATVLRGRLYAIAGY 528
Query: 258 NARLNRHFHDLWKFNPVSFTWKKIEPKGKGPC 289
+ N + ++P+ +W+ + G C
Sbjct: 529 DG--NSLLSSIECYDPIIDSWEVVTSMGTQRC 558
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 49.7 bits (117), Expect = 4e-06
Identities = 49/193 (25%), Positives = 70/193 (36%), Gaps = 31/193 (16%)
Query: 107 AFDVNTHKWFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFS----------ND 156
AFDV H+W R +P GHS C G +++ GG S
Sbjct: 338 AFDVYNHRW---RSLTQLPTPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQ 394
Query: 157 IHKLDTSTMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRI 216
+H+ D WT + PA R+ + G+ G R G + E+ + +
Sbjct: 395 VHRYDPRFHAWTEV-----PA-MREARAHFWCGA----VGERLLAVGGLGAGGEVLAS-V 443
Query: 217 RVFDTRTEAWLDCPPTPVLPEGRRSHS-AFGYNGELYIFGGYNARLN---RHFHDLWKFN 272
++D R + W LP H+ A G G +YI GG R DL+
Sbjct: 444 EMYDLRRDRW---TAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYVLG 500
Query: 273 PVSFTWKKIEPKG 285
P W K P G
Sbjct: 501 PEEQVWSKKAPMG 513
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 48.1 bits (113), Expect = 1e-05
Identities = 62/277 (22%), Positives = 96/277 (34%), Gaps = 41/277 (14%)
Query: 3 RWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPV 62
RW V RR AVG+R+Y+ GGY D T V ++ V+ W P V
Sbjct: 368 RWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLAT-----VESYDPVTNTWQ--PEV 420
Query: 63 KSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSG 122
R V + +L G D N +D T W +
Sbjct: 421 SMGTRRSCLGVAALH----------GLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMS 470
Query: 123 TVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDF 182
T R L +Y GGY+ + + + K + W+ + + S R
Sbjct: 471 T---RRRYVRVATLDGNLYAVGGYDSSSHLAT--VEKYEPQVNVWSPVASMLSR---RSS 522
Query: 183 HSATMLGSHMYVFGGRADRFGPFHSNNEIYC-NRIRVFDTRTEAWLDCPPTPVLPEGRRS 241
+L +YV GG N+ C N + + + AW P + R +
Sbjct: 523 AGVAVLEGALYVAGG----------NDGTSCLNSVERYSPKAGAWESVAPMNI---RRST 569
Query: 242 HSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTW 278
H +G LY GG + + + + K+NP + W
Sbjct: 570 HDLVAMDGWLYAVGGNDG--SSSLNSIEKYNPRTNKW 604
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.469
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,353,799
Number of Sequences: 37866
Number of extensions: 851525
Number of successful extensions: 1617
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 1212
Number of HSP's gapped (non-prelim): 210
length of query: 382
length of database: 18,247,518
effective HSP length: 104
effective length of query: 278
effective length of database: 14,309,454
effective search space: 3978028212
effective search space used: 3978028212
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.