Guide to the Human Genome
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Search of human proteins with 16936528

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
         (298 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        605   e-173
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]       515   e-146
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   467   e-132
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             397   e-111
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           395   e-110
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   350   9e-97
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        317   6e-87
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          317   6e-87
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   316   2e-86
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]         311   6e-85
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         311   6e-85
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         311   6e-85
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    287   9e-78
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...   270   9e-73
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...   270   9e-73
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...   270   9e-73
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...   270   9e-73
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...   270   9e-73
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...   270   9e-73
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]    268   3e-72
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]    268   3e-72
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]                 268   4e-72
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]                   268   4e-72
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   266   2e-71
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]                   262   3e-70
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      258   4e-69
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        244   5e-65
gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]                   243   1e-64
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   237   8e-63
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   237   8e-63

>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  605 bits (1559), Expect = e-173
 Identities = 298/298 (100%), Positives = 298/298 (100%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
           PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
Sbjct: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120

Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
           HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180

Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
           STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240

Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298
           PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Sbjct: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298


>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
          Length = 264

 Score =  515 bits (1327), Expect = e-146
 Identities = 264/298 (88%), Positives = 264/298 (88%), Gaps = 34/298 (11%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
           PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
Sbjct: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120

Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
           HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE                  
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHE------------------ 162

Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
                           VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
Sbjct: 163 ----------------VTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 206

Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298
           PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Sbjct: 207 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 264


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  467 bits (1202), Expect = e-132
 Identities = 227/297 (76%), Positives = 259/297 (87%), Gaps = 1/297 (0%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           M+ FQKVEKIGEGTYGVVYKA+N+ TG++VALKKIRLD E EGVPSTAIREISLLKEL H
Sbjct: 1   MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
           PNIV+LLDV+H E KLYLVFEFL QDLKK+MD++  + +PL LIKSYLFQLLQG++FCHS
Sbjct: 61  PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120

Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
           HRV+HRDLKPQNLLIN  GAIKLADFGLARAFGVP+RTYTHEVVTLWYRAPEILLG K+Y
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180

Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 240
           +TAVDIWS+GCIFAEMVTR+ALFPGDSEIDQLFRIFR LGTP E  WPGVT +PDYK SF
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSF 240

Query: 241 PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLR 297
           PKW R+   ++VP L+ +GR LL Q+L YDP++RI+AK ALAHP+F    +P P  R
Sbjct: 241 PKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS-PEPSPAAR 296


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  397 bits (1019), Expect = e-111
 Identities = 196/295 (66%), Positives = 235/295 (79%), Gaps = 3/295 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFC 118
           PNIV L DV+  +++LYL+FEFL  DLKK++D S   G  +   L+KSYL+Q+LQG+ FC
Sbjct: 61  PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLD-SIPPGQYMDSSLVKSYLYQILQGIVFC 119

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           HS RVLHRDLKPQNLLI+ +G IKLADFGLARAFG+P+R YTHEVVTLWYR+PE+LLG  
Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSA 179

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            YST VDIWS+G IFAE+ T++ LF GDSEIDQLFRIFR LGTP+  VWP V S+ DYK 
Sbjct: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239

Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
           +FPKW     +  V  LDE+G  LLS+ML YDP KRIS K AL HP+F D+   +
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  395 bits (1014), Expect = e-110
 Identities = 194/295 (65%), Positives = 234/295 (79%), Gaps = 3/295 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           ME++ K+EKIGEGTYGVVYK R+K TG+VVA+KKIRL++E EGVPSTAIREISLLKEL H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG--IPLPLIKSYLFQLLQGLAFC 118
           PNIV L DV+  +++LYL+FEFL  DLKK++D S   G  +   L+KSYL+Q+LQG+ FC
Sbjct: 61  PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLD-SIPPGQYMDSSLVKSYLYQILQGIVFC 119

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           HS RVLHRDLKPQNLLI+ +G IKLADFGLARAFG+P+R YTHE +TLWYR+PE+LLG  
Sbjct: 120 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSA 179

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            YST VDIWS+G IFAE+ T++ LF GDSEIDQLFRIFR LGTP+  VWP V S+ DYK 
Sbjct: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN 239

Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
           +FPKW     +  V  LDE+G  LLS+ML YDP KRIS K AL HP+F D+   +
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQI 294


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  350 bits (898), Expect = 9e-97
 Identities = 176/294 (59%), Positives = 219/294 (74%), Gaps = 4/294 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           M+ ++K+EKIGEGTYG V+KA+N+ T E+VALK++RLD + EGVPS+A+REI LLKEL H
Sbjct: 1   MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
            NIV+L DV+H++ KL LVFEF  QDLKK+ D S    +   ++KS+LFQLL+GL FCHS
Sbjct: 61  KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFD-SCNGDLDPEIVKSFLFQLLKGLGFCHS 119

Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
             VLHRDLKPQNLLIN  G +KLADFGLARAFG+PVR Y+ EVVTLWYR P++L G K Y
Sbjct: 120 RNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179

Query: 181 STAVDIWSLGCIFAEMVTR-RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239
           ST++D+WS GCIFAE+    R LFPG+   DQL RIFR LGTP E  WP +T +PDYKP 
Sbjct: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP- 238

Query: 240 FPKW-ARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292
           +P + A      VVP L+  GR LL  +L  +P +RISA+ AL HP+F D   P
Sbjct: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP 292


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  317 bits (813), Expect = 6e-87
 Identities = 159/287 (55%), Positives = 208/287 (72%), Gaps = 3/287 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E + K++K+GEGTY  VYK ++KLT  +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 226

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
            NIV L D+IHTE  L LVFE+L +DLK+++D      I +  +K +LFQLL+GLA+CH 
Sbjct: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLLRGLAYCHR 285

Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
            +VLHRDLKPQNLLIN  G +KLADFGLARA  +P +TY++EVVTLWYR P+ILLG   Y
Sbjct: 286 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 345

Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
           ST +D+W +GCIF EM T R LFPG +  +QL  IFR LGTP E  WPG+ S  ++K  +
Sbjct: 346 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 405

Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286
           +PK+  +      P LD DG  LL+++L ++   RISA+ A+ HPFF
Sbjct: 406 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  317 bits (813), Expect = 6e-87
 Identities = 159/287 (55%), Positives = 208/287 (72%), Gaps = 3/287 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E + K++K+GEGTY  VYK ++KLT  +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 220

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
            NIV L D+IHTE  L LVFE+L +DLK+++D      I +  +K +LFQLL+GLA+CH 
Sbjct: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLLRGLAYCHR 279

Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
            +VLHRDLKPQNLLIN  G +KLADFGLARA  +P +TY++EVVTLWYR P+ILLG   Y
Sbjct: 280 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 339

Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
           ST +D+W +GCIF EM T R LFPG +  +QL  IFR LGTP E  WPG+ S  ++K  +
Sbjct: 340 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 399

Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286
           +PK+  +      P LD DG  LL+++L ++   RISA+ A+ HPFF
Sbjct: 400 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 446


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  316 bits (809), Expect = 2e-86
 Identities = 155/290 (53%), Positives = 211/290 (72%), Gaps = 3/290 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           ME + K+EK+GEGTY  VYK R+KLT  +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 247

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
            NIV L D++HT+  L LVFE+L +DLK++MD      + +  +K +L+Q+L+GLA+CH 
Sbjct: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNI-MSMHNVKLFLYQILRGLAYCHR 306

Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
            +VLHRDLKPQNLLIN +G +KLADFGLARA  VP +TY++EVVTLWYR P++LLG   Y
Sbjct: 307 RKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEY 366

Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
           ST +D+W +GCIF EM + R LFPG +  D+L  IFR LGTP +  WPG++S  ++K  +
Sbjct: 367 STQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYN 426

Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289
           FPK+  Q      P LD +G  L+++ L Y+  KR+SA+ A+ H +F+ +
Sbjct: 427 FPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSL 476


>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
          Length = 504

 Score =  311 bits (796), Expect = 6e-85
 Identities = 158/297 (53%), Positives = 210/297 (70%), Gaps = 3/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E + K++K+GEGTY  V+K R+KLT  +VALK+IRL+ E EG P TAIRE+SLLK L H
Sbjct: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 229

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
            NIV L D+IHT+  L LVFE+L  DLK+++D      + +  +K ++FQLL+GLA+CH 
Sbjct: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLLRGLAYCHH 288

Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
            ++LHRDLKPQNLLIN  G +KLADFGLARA  VP +TY++EVVTLWYR P++LLG   Y
Sbjct: 289 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 348

Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
           ST +D+W +GCI  EM T R LFPG +  ++L  IFR LGTP E  WPGVT+  +++  S
Sbjct: 349 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 408

Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
           FP +  Q      P LD DG  LLS +L Y+   R+SA+AAL+H +F+ + + V  L
Sbjct: 409 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 465


>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  311 bits (796), Expect = 6e-85
 Identities = 158/297 (53%), Positives = 210/297 (70%), Gaps = 3/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E + K++K+GEGTY  V+K R+KLT  +VALK+IRL+ E EG P TAIRE+SLLK L H
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 199

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
            NIV L D+IHT+  L LVFE+L  DLK+++D      + +  +K ++FQLL+GLA+CH 
Sbjct: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLLRGLAYCHH 258

Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
            ++LHRDLKPQNLLIN  G +KLADFGLARA  VP +TY++EVVTLWYR P++LLG   Y
Sbjct: 259 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 318

Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
           ST +D+W +GCI  EM T R LFPG +  ++L  IFR LGTP E  WPGVT+  +++  S
Sbjct: 319 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 378

Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
           FP +  Q      P LD DG  LLS +L Y+   R+SA+AAL+H +F+ + + V  L
Sbjct: 379 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 435


>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  311 bits (796), Expect = 6e-85
 Identities = 158/297 (53%), Positives = 210/297 (70%), Gaps = 3/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E + K++K+GEGTY  V+K R+KLT  +VALK+IRL+ E EG P TAIRE+SLLK L H
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 199

Query: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
            NIV L D+IHT+  L LVFE+L  DLK+++D      + +  +K ++FQLL+GLA+CH 
Sbjct: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLLRGLAYCHH 258

Query: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
            ++LHRDLKPQNLLIN  G +KLADFGLARA  VP +TY++EVVTLWYR P++LLG   Y
Sbjct: 259 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 318

Query: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
           ST +D+W +GCI  EM T R LFPG +  ++L  IFR LGTP E  WPGVT+  +++  S
Sbjct: 319 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 378

Query: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
           FP +  Q      P LD DG  LLS +L Y+   R+SA+AAL+H +F+ + + V  L
Sbjct: 379 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 435


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  287 bits (734), Expect = 9e-78
 Identities = 151/292 (51%), Positives = 202/292 (69%), Gaps = 6/292 (2%)

Query: 2   ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHP 61
           ++++K+EK+GEG+Y  VYK ++K+ G++VALK IRL  E EG P TAIRE SLLK L H 
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173

Query: 62  NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 121
           NIV L D+IHT+  L LVFE++H DL ++MD     G+    +K +LFQLL+GL++ H  
Sbjct: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHP-GGLHPDNVKLFLFQLLRGLSYIHQR 232

Query: 122 RVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYS 181
            +LHRDLKPQNLLI+  G +KLADFGLARA  VP  TY++EVVTLWYR P++LLG   YS
Sbjct: 233 YILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYS 292

Query: 182 TAVDIWSLGCIFAEMVTRRALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS- 239
           T +D+W +GCIF EM+   A FPG  +I DQL RIF  LGTP+E  WPGV S+P +KP  
Sbjct: 293 TCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER 352

Query: 240 FPKWARQDFSKVVPPLD--EDGRSLLSQMLHYDPNKRISAKAALAHPFFQDV 289
           F  ++ ++  +    L        L S++L   P  R+SA+AAL+H +F D+
Sbjct: 353 FTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDL 404


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score =  270 bits (691), Expect = 9e-73
 Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470

Query: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 529

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVTLWYRAPE+LLG K
Sbjct: 530 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 589

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 590 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 649

Query: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 650 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 706


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score =  270 bits (691), Expect = 9e-73
 Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479

Query: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 538

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVTLWYRAPE+LLG K
Sbjct: 539 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 598

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 599 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 658

Query: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 659 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 715


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score =  270 bits (691), Expect = 9e-73
 Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 388 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 447

Query: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 448 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 506

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVTLWYRAPE+LLG K
Sbjct: 507 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 566

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 567 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 626

Query: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 627 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 683


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score =  270 bits (691), Expect = 9e-73
 Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436

Query: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 495

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVTLWYRAPE+LLG K
Sbjct: 496 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 555

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 556 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 615

Query: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 616 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 672


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score =  270 bits (691), Expect = 9e-73
 Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225

Query: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 284

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVTLWYRAPE+LLG K
Sbjct: 285 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 344

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 345 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 404

Query: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 405 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 461


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score =  270 bits (691), Expect = 9e-73
 Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481

Query: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 540

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVTLWYRAPE+LLG K
Sbjct: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660

Query: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 717


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score =  268 bits (686), Expect = 3e-72
 Identities = 132/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469

Query: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 528

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVT WYRAPE+LLG K
Sbjct: 529 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 588

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            YSTAVD+WS+GCIF E++T++ LFPG+SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 589 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 648

Query: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 649 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 705


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score =  268 bits (686), Expect = 3e-72
 Identities = 132/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479

Query: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 538

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVT WYRAPE+LLG K
Sbjct: 539 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 598

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            YSTAVD+WS+GCIF E++T++ LFPG+SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 599 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 658

Query: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 659 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 715


>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  268 bits (685), Expect = 4e-72
 Identities = 145/299 (48%), Positives = 198/299 (66%), Gaps = 13/299 (4%)

Query: 2   ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59
           + ++ V +IGEG YG V+KAR+ K  G  VALK++R+ T  EG+P + IRE+++L+ L  
Sbjct: 11  QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70

Query: 60  --HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112
             HPN+V+L DV        E KL LVFE + QDL  ++D     G+P   IK  +FQLL
Sbjct: 71  FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130

Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172
           +GL F HSHRV+HRDLKPQN+L+ + G IKLADFGLAR +   +   T  VVTLWYRAPE
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189

Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232
           +LL    Y+T VD+WS+GCIFAEM  R+ LF G S++DQL +I   +G P E  WP   +
Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248

Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291
           +P  + +F   + Q   K V  +DE G+ LL + L ++P KRISA +AL+HP+FQD+ +
Sbjct: 249 LP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305


>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  268 bits (685), Expect = 4e-72
 Identities = 145/299 (48%), Positives = 198/299 (66%), Gaps = 13/299 (4%)

Query: 2   ENFQKVEKIGEGTYGVVYKARN-KLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN- 59
           + ++ V +IGEG YG V+KAR+ K  G  VALK++R+ T  EG+P + IRE+++L+ L  
Sbjct: 11  QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70

Query: 60  --HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112
             HPN+V+L DV        E KL LVFE + QDL  ++D     G+P   IK  +FQLL
Sbjct: 71  FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130

Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172
           +GL F HSHRV+HRDLKPQN+L+ + G IKLADFGLAR +   +   T  VVTLWYRAPE
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWYRAPE 189

Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232
           +LL    Y+T VD+WS+GCIFAEM  R+ LF G S++DQL +I   +G P E  WP   +
Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248

Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTK 291
           +P  + +F   + Q   K V  +DE G+ LL + L ++P KRISA +AL+HP+FQD+ +
Sbjct: 249 LP--RQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  266 bits (679), Expect = 2e-71
 Identities = 134/300 (44%), Positives = 194/300 (64%), Gaps = 5/300 (1%)

Query: 2   ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETE---GVPSTAIREISLLKEL 58
           + ++K++ +GEG +  VYKAR+K T ++VA+KKI+L   +E   G+  TA+REI LL+EL
Sbjct: 10  KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69

Query: 59  NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118
           +HPNI+ LLD    ++ + LVF+F+  DL+  +  ++L   P   IK+Y+   LQGL + 
Sbjct: 70  SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSH-IKAYMLMTLQGLEYL 128

Query: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178
           H H +LHRDLKP NLL++  G +KLADFGLA++FG P R YTH+VVT WYRAPE+L G +
Sbjct: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238
            Y   VD+W++GCI AE++ R    PGDS++DQL RIF TLGTP E  WP + S+PDY  
Sbjct: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDY-V 247

Query: 239 SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 298
           +F  +       +     +D   L+  +  ++P  RI+A  AL   +F +   P P  +L
Sbjct: 248 TFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQL 307


>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
          Length = 384

 Score =  262 bits (669), Expect = 3e-70
 Identities = 143/288 (49%), Positives = 188/288 (65%), Gaps = 6/288 (2%)

Query: 3   NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
           ++  +EK+GEG+Y  VYK  +++ G++VALK I ++ E EGVP TAIRE SLLK L H N
Sbjct: 51  SYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHAN 109

Query: 63  IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
           IV L D+IHT+  L  VFE++H DL ++M      G+    ++ ++FQLL+GLA+ H   
Sbjct: 110 IVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHP-GGLHPHNVRLFMFQLLRGLAYIHHQH 168

Query: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182
           VLHRDLKPQNLLI+  G +KLADFGLARA  +P +TY+ EVVTLWYR P+ LLG   YS+
Sbjct: 169 VLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSS 228

Query: 183 AVDIWSLGCIFAEMVTRRALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS-F 240
            +DIW  GCIF EM   + LFPG S I +QL +I+  LG P E  WPGV+ +P+Y P  F
Sbjct: 229 ELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWF 288

Query: 241 PKWARQDFSKVVPPLDE--DGRSLLSQMLHYDPNKRISAKAALAHPFF 286
           P    +    V   L    +   L SQML   P  R+SA+ AL H +F
Sbjct: 289 PLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF 336


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  258 bits (659), Expect = 4e-69
 Identities = 137/302 (45%), Positives = 198/302 (65%), Gaps = 16/302 (5%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
           ++ F+K+ +IGEGTYG+VY+AR+  T E+VALKK+R+D E +G+P +++REI+LL  L H
Sbjct: 36  VKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRH 95

Query: 61  PNIVKLLDVI---HTENKLYLVFEFLHQDLKKFMDASALTGIPLPL----IKSYLFQLLQ 113
           PNIV+L +V+   H E+ ++LV  +  QDL     AS L  +P P     +K  + Q+L+
Sbjct: 96  PNIVELKEVVVGNHLES-IFLVMGYCEQDL-----ASLLENMPTPFSEAQVKCIVLQVLR 149

Query: 114 GLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEI 173
           GL + H + ++HRDLK  NLL+  +G +K ADFGLARA+GVPV+  T +VVTLWYRAPE+
Sbjct: 150 GLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPEL 209

Query: 174 LLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSM 233
           LLG    +T++D+W++GCI AE++  R L PG SEI Q+  I + LGTP E +WPG + +
Sbjct: 210 LLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKL 269

Query: 234 PDY-KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 292
           P   + S  K    +     P L E G  LL  +  YDP KR +A   L   +F++  KP
Sbjct: 270 PLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKE--KP 327

Query: 293 VP 294
           +P
Sbjct: 328 LP 329


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  244 bits (624), Expect = 5e-65
 Identities = 130/297 (43%), Positives = 187/297 (62%), Gaps = 6/297 (2%)

Query: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-N 59
           M+ +  + +IGEG +G+V+KA++  TGE+VALKK+ L    +G P+ A+REI  L+E+ +
Sbjct: 1   MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60

Query: 60  HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH 119
           +  +V+L  V        L FEF+  DL + +   A   +    +KSYL  LL+G+AFCH
Sbjct: 61  NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVV-RHAQRPLAQAQVKSYLQMLLKGVAFCH 119

Query: 120 SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-VRTYTHEVVTLWYRAPEILLGCK 178
           ++ ++HRDLKP NLLI+  G +K+ADFGLAR F     R YTH+V T WYRAPE+L G +
Sbjct: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGAR 179

Query: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-K 237
            Y   VD+WS+GCI  E++    LFPG ++I+QL  + R LGTP+  VWP +T +PDY K
Sbjct: 180 QYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 239

Query: 238 PSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVP 294
            SF +       +V+P +      LL Q L Y P++RI+A  AL H +F   T P+P
Sbjct: 240 ISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF--FTAPLP 294


>gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
          Length = 303

 Score =  243 bits (620), Expect = 1e-64
 Identities = 134/293 (45%), Positives = 189/293 (64%), Gaps = 15/293 (5%)

Query: 4   FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG---VPSTAIREISLLKELN- 59
           ++ V +IG G YG VYKAR+  +G  VALK +R+     G   +P + +RE++LL+ L  
Sbjct: 6   YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65

Query: 60  --HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 112
             HPN+V+L+DV  T     E K+ LVFE + QDL+ ++D +   G+P   IK  + Q L
Sbjct: 66  FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125

Query: 113 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 172
           +GL F H++ ++HRDLKP+N+L+ + G +KLADFGLAR +   +   T  VVTLWYRAPE
Sbjct: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184

Query: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232
           +LL    Y+T VD+WS+GCIFAEM  R+ LF G+SE DQL +IF  +G P E  WP   S
Sbjct: 185 VLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243

Query: 233 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPF 285
           +P  + +FP    +    VVP ++E G  LL +ML ++P+KRISA  AL H +
Sbjct: 244 LP--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  237 bits (605), Expect = 8e-63
 Identities = 131/305 (42%), Positives = 187/305 (61%), Gaps = 21/305 (6%)

Query: 1    MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
            ++ F  +  IGEGTYG VYKA++K TGE+VALKK+RLD E EG P TAIREI +L++L H
Sbjct: 724  VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783

Query: 61   PNIVKLLDVI----------HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110
             ++V + +++            +   YLVFE++  DL   ++ S L       IKS++ Q
Sbjct: 784  RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLE-SGLVHFSEDHIKSFMKQ 842

Query: 111  LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-RTYTHEVVTLWYR 169
            L++GL +CH    LHRD+K  N+L+N  G IKLADFGLAR +     R YT++V+TLWYR
Sbjct: 843  LMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 902

Query: 170  APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
             PE+LLG + Y+ A+D+WS GCI  E+ T++ +F  + E+ QL  I R  G+P   VWP 
Sbjct: 903  PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPD 962

Query: 230  VTSMPDY-----KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284
            V  +P +     K  + +  R++FS  +P    D   LL  ML  DP+KR +A+  L   
Sbjct: 963  VIKLPYFNTMKPKKQYRRRLREEFS-FIPSAALD---LLDHMLTLDPSKRCTAEQTLQSD 1018

Query: 285  FFQDV 289
            F +DV
Sbjct: 1019 FLKDV 1023


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  237 bits (605), Expect = 8e-63
 Identities = 131/305 (42%), Positives = 187/305 (61%), Gaps = 21/305 (6%)

Query: 1    MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
            ++ F  +  IGEGTYG VYKA++K TGE+VALKK+RLD E EG P TAIREI +L++L H
Sbjct: 724  VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783

Query: 61   PNIVKLLDVI----------HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQ 110
             ++V + +++            +   YLVFE++  DL   ++ S L       IKS++ Q
Sbjct: 784  RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLE-SGLVHFSEDHIKSFMKQ 842

Query: 111  LLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPV-RTYTHEVVTLWYR 169
            L++GL +CH    LHRD+K  N+L+N  G IKLADFGLAR +     R YT++V+TLWYR
Sbjct: 843  LMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 902

Query: 170  APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
             PE+LLG + Y+ A+D+WS GCI  E+ T++ +F  + E+ QL  I R  G+P   VWP 
Sbjct: 903  PPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPD 962

Query: 230  VTSMPDY-----KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHP 284
            V  +P +     K  + +  R++FS  +P    D   LL  ML  DP+KR +A+  L   
Sbjct: 963  VIKLPYFNTMKPKKQYRRRLREEFS-FIPSAALD---LLDHMLTLDPSKRCTAEQTLQSD 1018

Query: 285  FFQDV 289
            F +DV
Sbjct: 1019 FLKDV 1023


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,175,862
Number of Sequences: 37866
Number of extensions: 484698
Number of successful extensions: 3578
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 750
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 978
Number of HSP's gapped (non-prelim): 968
length of query: 298
length of database: 18,247,518
effective HSP length: 102
effective length of query: 196
effective length of database: 14,385,186
effective search space: 2819496456
effective search space used: 2819496456
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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