Search of human proteins with 169218211

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
sapiens]
         (1369 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...  2719   0.0  
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                       2703   0.0  
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                       2363   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                      2363   0.0  
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                      2363   0.0  
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                       2363   0.0  
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                       2363   0.0  
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                       2363   0.0  
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                       2363   0.0  
gi|33188445 microfilament and actin filament cross-linker protei...  1142   0.0  
gi|221316624 dystonin isoform 4 [Homo sapiens]                        667   0.0  
gi|221316622 dystonin isoform 3 [Homo sapiens]                        667   0.0  
gi|221316618 dystonin isoform 2 [Homo sapiens]                        667   0.0  
gi|34577047 dystonin isoform 1 [Homo sapiens]                         667   0.0  
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]             667   0.0  
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             667   0.0  
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]               667   0.0  
gi|58530842 desmoplakin isoform II [Homo sapiens]                     460   e-129
gi|58530840 desmoplakin isoform I [Homo sapiens]                      460   e-129
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]          351   3e-96
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...   338   2e-92
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...   338   2e-92
gi|67782321 spectrin beta isoform a [Homo sapiens]                    337   4e-92
gi|67782319 spectrin beta isoform b [Homo sapiens]                    337   4e-92
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...   299   1e-80
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]        254   5e-67
gi|12025678 actinin, alpha 4 [Homo sapiens]                           246   1e-64
gi|4557241 actinin, alpha 3 [Homo sapiens]                            245   2e-64
gi|45439327 periplakin [Homo sapiens]                                 243   1e-63
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]                238   3e-62

>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score = 2719 bits (7047), Expect = 0.0
 Identities = 1369/1369 (100%), Positives = 1369/1369 (100%)

Query: 1    MLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRET 60
            MLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRET
Sbjct: 1    MLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRET 60

Query: 61   FAWCHFFWYLTNEGIAHLRQYLHLPPEIVAASLQRVRRPVAMVMPARRTPHVQAVQGPLG 120
            FAWCHFFWYLTNEGIAHLRQYLHLPPEIVAASLQRVRRPVAMVMPARRTPHVQAVQGPLG
Sbjct: 61   FAWCHFFWYLTNEGIAHLRQYLHLPPEIVAASLQRVRRPVAMVMPARRTPHVQAVQGPLG 120

Query: 121  SPPKRGPLPTEEQRLYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKT 180
            SPPKRGPLPTEEQRLYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKT
Sbjct: 121  SPPKRGPLPTEEQRLYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKT 180

Query: 181  STKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIAL 240
            STKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIAL
Sbjct: 181  STKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIAL 240

Query: 241  DYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLW 300
            DYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLW
Sbjct: 241  DYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLW 300

Query: 301  SQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAE 360
            SQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAE
Sbjct: 301  SQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAE 360

Query: 361  RDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYREL 420
            RDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYREL
Sbjct: 361  RDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYREL 420

Query: 421  VLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLE 480
            VLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLE
Sbjct: 421  VLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLE 480

Query: 481  GAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGL 540
            GAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGL
Sbjct: 481  GAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGL 540

Query: 541  CEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 600
            CEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG
Sbjct: 541  CEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 600

Query: 601  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD 660
            EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD
Sbjct: 601  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD 660

Query: 661  LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATR 720
            LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATR
Sbjct: 661  LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATR 720

Query: 721  GAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR 780
            GAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR
Sbjct: 721  GAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR 780

Query: 781  NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 840
            NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM
Sbjct: 781  NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 840

Query: 841  LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDA 900
            LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDA
Sbjct: 841  LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDA 900

Query: 901  QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE 960
            QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE
Sbjct: 901  QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE 960

Query: 961  CQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLH 1020
            CQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLH
Sbjct: 961  CQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLH 1020

Query: 1021 VDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFG 1080
            VDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFG
Sbjct: 1021 VDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFG 1080

Query: 1081 PEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL 1140
            PEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL
Sbjct: 1081 PEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL 1140

Query: 1141 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1200
            RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL
Sbjct: 1141 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1200

Query: 1201 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1260
            ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA
Sbjct: 1201 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1260

Query: 1261 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1320
            TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER
Sbjct: 1261 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1320

Query: 1321 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369
            WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1321 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 2703 bits (7006), Expect = 0.0
 Identities = 1360/1369 (99%), Positives = 1365/1369 (99%)

Query: 1    MLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRET 60
            MLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRET
Sbjct: 5    MLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRET 64

Query: 61   FAWCHFFWYLTNEGIAHLRQYLHLPPEIVAASLQRVRRPVAMVMPARRTPHVQAVQGPLG 120
            FAWCHF+WYLTNEGIAHLRQYLHLPPEIV ASLQRVRRPVAMVMPARRTPHVQAVQGPLG
Sbjct: 65   FAWCHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLG 124

Query: 121  SPPKRGPLPTEEQRLYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKT 180
            SPPKRGPLPTEEQR+YRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKT
Sbjct: 125  SPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKT 184

Query: 181  STKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIAL 240
             TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIAL
Sbjct: 185  FTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIAL 244

Query: 241  DYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLW 300
            DYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLW
Sbjct: 245  DYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLW 304

Query: 301  SQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAE 360
            SQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAE
Sbjct: 305  SQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAE 364

Query: 361  RDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYREL 420
            RDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYREL
Sbjct: 365  RDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYREL 424

Query: 421  VLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLE 480
            VLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLE
Sbjct: 425  VLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLE 484

Query: 481  GAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGL 540
            GAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGL
Sbjct: 485  GAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGL 544

Query: 541  CEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 600
            CEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG
Sbjct: 545  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 604

Query: 601  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD 660
            EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD
Sbjct: 605  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD 664

Query: 661  LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATR 720
            LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARSDEGQLSPATR
Sbjct: 665  LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATR 724

Query: 721  GAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR 780
            GAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR
Sbjct: 725  GAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR 784

Query: 781  NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 840
            NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM
Sbjct: 785  NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 844

Query: 841  LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDA 900
            LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATVTRLEDLLQDA
Sbjct: 845  LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDA 904

Query: 901  QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE 960
            QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE
Sbjct: 905  QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE 964

Query: 961  CQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLH 1020
            CQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQALVTLWHQLH
Sbjct: 965  CQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLH 1024

Query: 1021 VDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFG 1080
            VDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFG
Sbjct: 1025 VDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFG 1084

Query: 1081 PEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL 1140
            PEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL
Sbjct: 1085 PEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL 1144

Query: 1141 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1200
            RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL
Sbjct: 1145 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1204

Query: 1201 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1260
            ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA
Sbjct: 1205 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1264

Query: 1261 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1320
            TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER
Sbjct: 1265 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324

Query: 1321 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369
            WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%)

Query: 287  QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
            ++E   A+EK     QR ++  + LR     +   + RL  A + R + + + +    R 
Sbjct: 1659 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1710

Query: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403
               E   +  S AE+   + R L  E V V Q  E++             R    ++   
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770

Query: 404  -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
              ++ANE L+LR Q     ++  L   +  +    A  E R     EE  +        +
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1822

Query: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514
            + EL  +E +K R     Q  EG  Q  +L        L  E E G+    +LE E    
Sbjct: 1823 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1876

Query: 515  ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544
                                           + R+E E     ++   +L+ EAG   E 
Sbjct: 1877 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936

Query: 545  LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587
              +A  L  L  +    R LA     ++  E ER L             K ++ I L   
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1996

Query: 588  DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647
            + +  +  R  + E   RR  RL E+    + +   RL         Q+ + +   ++R+
Sbjct: 1997 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 2046

Query: 648  PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705
              L + TLR  + +   +   +   + A  G     +E +LG  R   +     + QA++
Sbjct: 2047 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 2104

Query: 706  ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765
            E AR  + QL+       R+   R+    A    +++ R  +LE +   + A  +E   L
Sbjct: 2105 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 2161

Query: 766  NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
             E+ E+E      +  + + +      K  +++   +E EL++  +++ Q+  D+L  E 
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2220

Query: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
              AR   E  +                 EA ++      Q    V EAE   Q  +E  +
Sbjct: 2221 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2263

Query: 880  RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935
             +     +A   R E   +  + AQ E+  L + +   + + K  K   Q L+ +     
Sbjct: 2264 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2323

Query: 936  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995
                L L       Q+E T H+ +   L    Q    +   ++   + V    F V    
Sbjct: 2324 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2374

Query: 996  QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048
            +E+ +   R+EA+++AL+         + Q   +    +A ++ R  V    +   A  R
Sbjct: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2431

Query: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108
             L  E+  Q     E   +  ++  Q+A       RL AE E          LLQ  ++ 
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2475

Query: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159
            AQE++R          Q+   E +  +  LEA   R     +L +  E A     R+AE 
Sbjct: 2476 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2529

Query: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197
             +AQA  E   +   R   +AE++        LA  E      TL               
Sbjct: 2530 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2586

Query: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252
               +ELE    KL+Q   L  +  E+++T+    +++ TQ  ++   + ++ L + +   
Sbjct: 2587 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2645

Query: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
                 +E  KA L++L     A+AQQ     LR+E +  Q+  E+ +QR      E  R 
Sbjct: 2646 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2695

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338
            +    + + R Q  L Q + ++R+ E+L
Sbjct: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2723



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%)

Query: 433  AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492
            AA E++R   + EE+       L+ +E E   ++A+  R++ +  +LE A ++ + ++  
Sbjct: 1664 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717

Query: 493  -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528
                       +E+   + HVA+       ER  Q ++E ER             L+  +
Sbjct: 1718 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1777

Query: 529  RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588
             +  +LQ E    ++ L QA+A  Q +     A +  +R G+ E    +   +       
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1833

Query: 589  VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642
             + L +G   Q     + + RL       E+   +  E   RL+   AA   +  ++  +
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1893

Query: 643  SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699
              + R E+E    S  R  ++  +  E+++ R+            EA+ G  R L +   
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1941

Query: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752
              +A  E A+    QL+       R    R+  +         +L   ++  L+  E+ +
Sbjct: 1942 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000

Query: 753  SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811
              +    ++  +   + EE+     +D    +   +K S S L R+  L E  +++ +  
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060

Query: 812  GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871
             + +L           SF+ A   +    L+L       ++ NA       +  E E   
Sbjct: 2061 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 2108

Query: 872  QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
            Q+    +E  RR+ + +R       E+  + A+  K  L E +  L    + A+ + +  
Sbjct: 2109 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 2165

Query: 929  PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982
             +  A  ++  L   A     Q E   H      K  E Q     + S    L      A
Sbjct: 2166 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2223

Query: 983  AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
               +         +E +EA  R++A+ +A  +   +  V+    L  QS     Q  R+ 
Sbjct: 2224 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2267

Query: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
            + A    L+ E +++A    +   QA LR  Q A     + +  AE              
Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2312

Query: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156
            Q+L Q AQ E        EL  +RLQLE  + +       + RL+     E AR+ +Q  
Sbjct: 2313 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2364

Query: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
             E    + ++E L K  AR+ AE  + L L +       L+ E E      E+   LS  
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2423

Query: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271
              E  +   L    + +    AE++L+   + ++EA  + A    L+  K  + ++ R  
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2483

Query: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331
             E ++     L +E +G Q   E  +QR  E   E ER + RVA+ + R QA  A+ D +
Sbjct: 2484 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2541

Query: 1332 --QRELEQLGRQL 1342
              +++ E++G +L
Sbjct: 2542 RFRKQAEEIGEKL 2554



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 164/750 (21%), Positives = 291/750 (38%), Gaps = 146/750 (19%)

Query: 639  VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690
            V  Q+  R+ ELE     LRY ++    L AW+++ + R +  +     D  +V  QL  
Sbjct: 1328 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1387

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
             + L + IE    K+E  +    Q   A +             Y   L + KA+L  + S
Sbjct: 1388 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1435

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY----SALMRELELKEKKIK 806
                   A K  +    +   +   D     + +T     Y    S  +R +E +E+++ 
Sbjct: 1436 ------PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLA 1488

Query: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
            E Q A +R           +   +AAL+ Q     QL    EAH +  A          +
Sbjct: 1489 EQQRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------Q 1522

Query: 867  AEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 926
            AE + ++LQ+ ++ +        V R E+   DAQ +K  + E    L  L + ++A +Q
Sbjct: 1523 AEREAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQ 1571

Query: 927  LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 986
             K R      R RL +       ++++   +       G  Q      L +   EA    
Sbjct: 1572 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK 1626

Query: 987  VCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 1046
                     ++ QE   RL  Q Q       Q  V++ S      ++ + +  R      
Sbjct: 1627 ---------RQAQEEAERLRRQVQDESQRKRQAEVELAS-----RVKAEAEAAR------ 1666

Query: 1047 FRTLKPEEQRQALHSLE-LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSL 1105
                   E+++AL +LE L  QA     ++A      +R + + E    +   Q  L++ 
Sbjct: 1667 -------EKQRALQALEELRLQA-----EEA------ERRLRQAEVER-ARQVQVALETA 1707

Query: 1106 EQGAQEESRCQRCISELKDIRLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQA 1164
            ++ A+ E + +R     K  +L+    E    V +LR     E A   AQ+ AE ++A+ 
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-----EEAERRAQQQAEAERARE 1762

Query: 1165 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1224
            E E   + + R   +A + L               L L   ++ Q +SL+    EK K  
Sbjct: 1763 EAE---RELERWQLKANEAL--------------RLRLQAEEVAQQKSLAQAEAEKQKEE 1805

Query: 1225 SL--VIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1278
            +     R  +  E+ +R    A +E  K+ Q    T  +  A +  L +LRA+ E  +  
Sbjct: 1806 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1865

Query: 1279 FDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDVRQRE 1334
               L +EL   Q       Q+  E + E+ + R  +  LL       +   + ++  ++ 
Sbjct: 1866 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1925

Query: 1335 LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
            LE    + R   E A  L A  ++A+R+++
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQ 1955



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%)

Query: 693  GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
            GL + +    A+ E+  A  +    +P  R      LG+L+    ++ + S   L  L++
Sbjct: 1172 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1227

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803
            + S V   T+    +    EE++    +   T   + A K S   L  + E ++      
Sbjct: 1228 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1286

Query: 804  --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858
              +++  Q  G+RL +        VE ++   A L  +W  +L      +  L++     
Sbjct: 1287 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1346

Query: 859  QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918
            +++ +  +  G    LQ+A RR+               L D+Q  +EQL + +  L  + 
Sbjct: 1347 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1396

Query: 919  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978
            +  + V + +     +       + A+ DY ++++  +K     +  PA+    K    S
Sbjct: 1397 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1444

Query: 979  GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038
            GSE+ +     L     +     +T L +Q+   ++   +   + + L   Q      +L
Sbjct: 1445 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499

Query: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098
                +    +    E   QA    E   +   +  Q+      E  + A+++  S     
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1559

Query: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144
            QQL QS E   Q ++R          R   E++ +RLQLEA E +       +  LR   
Sbjct: 1560 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1619

Query: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193
            +     K  A+E A+R+  Q      +K QAEVE   +  A   A  EK  AL     A 
Sbjct: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1675

Query: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230
              LR + E    +L Q                       ++S  A + EK   +   ++ 
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735

Query: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280
               A   LR   E+  + QA      E          L+A +A   +L+A+  AQQ +  
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1794

Query: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333
              + E    +E  ER  +R G+ + +  R RE   Q LE+ Q  LA+   +QR       
Sbjct: 1795 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1852

Query: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368
                 E EQ  +Q +   E    L      A +++++++A
Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 2363 bits (6125), Expect = 0.0
 Identities = 1203/1253 (96%), Positives = 1211/1253 (96%), Gaps = 7/1253 (0%)

Query: 117  GPLGSPPKRGPLPTEEQRLYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRV 176
            G  GSP     LP    +  R +     +     V    +R + R         DERDRV
Sbjct: 18   GSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIR-------IADERDRV 70

Query: 177  QKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV 236
            QKKT TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV
Sbjct: 71   QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV 130

Query: 237  QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK 296
            QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK
Sbjct: 131  QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK 190

Query: 297  LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 356
            LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF
Sbjct: 191  LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 250

Query: 357  SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE 416
            SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE
Sbjct: 251  SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE 310

Query: 417  YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 476
            YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY
Sbjct: 311  YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 370

Query: 477  QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM 536
            QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM
Sbjct: 371  QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM 430

Query: 537  EAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR 596
            EAGLCEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR
Sbjct: 431  EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR 490

Query: 597  HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR 656
            HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR
Sbjct: 491  HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR 550

Query: 657  YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLS 716
            YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARSDEGQLS
Sbjct: 551  YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 610

Query: 717  PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD 776
            PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD
Sbjct: 611  PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD 670

Query: 777  WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ 836
            WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ
Sbjct: 671  WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ 730

Query: 837  WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDL 896
            WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATVTRLEDL
Sbjct: 731  WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 790

Query: 897  LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 956
            LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH
Sbjct: 791  LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 850

Query: 957  KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLW 1016
            KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQALVTLW
Sbjct: 851  KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 910

Query: 1017 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 1076
            HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA
Sbjct: 911  HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 970

Query: 1077 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 1136
            GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT
Sbjct: 971  GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 1030

Query: 1137 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1196
            VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL
Sbjct: 1031 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1090

Query: 1197 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1256
            RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP
Sbjct: 1091 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1150

Query: 1257 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1316
            ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ
Sbjct: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210

Query: 1317 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369
            LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1263



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%)

Query: 287  QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
            ++E   A+EK     QR ++  + LR     +   + RL  A + R + + + +    R 
Sbjct: 1549 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1600

Query: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403
               E   +  S AE+   + R L  E V V Q  E++             R    ++   
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660

Query: 404  -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
              ++ANE L+LR Q     ++  L   +  +    A  E R     EE  +        +
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1712

Query: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514
            + EL  +E +K R     Q  EG  Q  +L        L  E E G+    +LE E    
Sbjct: 1713 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1766

Query: 515  ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544
                                           + R+E E     ++   +L+ EAG   E 
Sbjct: 1767 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826

Query: 545  LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587
              +A  L  L  +    R LA     ++  E ER L             K ++ I L   
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1886

Query: 588  DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647
            + +  +  R  + E   RR  RL E+    + +   RL         Q+ + +   ++R+
Sbjct: 1887 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 1936

Query: 648  PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705
              L + TLR  + +   +   +   + A  G     +E +LG  R   +     + QA++
Sbjct: 1937 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 1994

Query: 706  ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765
            E AR  + QL+       R+   R+    A    +++ R  +LE +   + A  +E   L
Sbjct: 1995 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 2051

Query: 766  NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
             E+ E+E      +  + + +      K  +++   +E EL++  +++ Q+  D+L  E 
Sbjct: 2052 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2110

Query: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
              AR   E  +                 EA ++      Q    V EAE   Q  +E  +
Sbjct: 2111 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2153

Query: 880  RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935
             +     +A   R E   +  + AQ E+  L + +   + + K  K   Q L+ +     
Sbjct: 2154 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2213

Query: 936  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995
                L L       Q+E T H+ +   L    Q    +   ++   + V    F V    
Sbjct: 2214 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2264

Query: 996  QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048
            +E+ +   R+EA+++AL+         + Q   +    +A ++ R  V    +   A  R
Sbjct: 2265 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2321

Query: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108
             L  E+  Q     E   +  ++  Q+A       RL AE E          LLQ  ++ 
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2365

Query: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159
            AQE++R          Q+   E +  +  LEA   R     +L +  E A     R+AE 
Sbjct: 2366 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2419

Query: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197
             +AQA  E   +   R   +AE++        LA  E      TL               
Sbjct: 2420 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2476

Query: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252
               +ELE    KL+Q   L  +  E+++T+    +++ TQ  ++   + ++ L + +   
Sbjct: 2477 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2535

Query: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
                 +E  KA L++L     A+AQQ     LR+E +  Q+  E+ +QR      E  R 
Sbjct: 2536 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2585

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338
            +    + + R Q  L Q + ++R+ E+L
Sbjct: 2586 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2613



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%)

Query: 433  AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492
            AA E++R   + EE+       L+ +E E   ++A+  R++ +  +LE A ++ + ++  
Sbjct: 1554 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607

Query: 493  -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528
                       +E+   + HVA+       ER  Q ++E ER             L+  +
Sbjct: 1608 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1667

Query: 529  RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588
             +  +LQ E    ++ L QA+A  Q +     A +  +R G+ E    +   +       
Sbjct: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1723

Query: 589  VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642
             + L +G   Q     + + RL       E+   +  E   RL+   AA   +  ++  +
Sbjct: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1783

Query: 643  SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699
              + R E+E    S  R  ++  +  E+++ R+            EA+ G  R L +   
Sbjct: 1784 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1831

Query: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752
              +A  E A+    QL+       R    R+  +         +L   ++  L+  E+ +
Sbjct: 1832 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890

Query: 753  SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811
              +    ++  +   + EE+     +D    +   +K S S L R+  L E  +++ +  
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950

Query: 812  GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871
             + +L           SF+ A   +    L+L       ++ NA       +  E E   
Sbjct: 1951 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 1998

Query: 872  QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
            Q+    +E  RR+ + +R       E+  + A+  K  L E +  L    + A+ + +  
Sbjct: 1999 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 2055

Query: 929  PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982
             +  A  ++  L   A     Q E   H      K  E Q     + S    L      A
Sbjct: 2056 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2113

Query: 983  AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
               +         +E +EA  R++A+ +A  +   +  V+    L  QS     Q  R+ 
Sbjct: 2114 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2157

Query: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
            + A    L+ E +++A    +   QA LR  Q A     + +  AE              
Sbjct: 2158 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2202

Query: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156
            Q+L Q AQ E        EL  +RLQLE  + +       + RL+     E AR+ +Q  
Sbjct: 2203 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2254

Query: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
             E    + ++E L K  AR+ AE  + L L +       L+ E E      E+   LS  
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2313

Query: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271
              E  +   L    + +    AE++L+   + ++EA  + A    L+  K  + ++ R  
Sbjct: 2314 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2373

Query: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331
             E ++     L +E +G Q   E  +QR  E   E ER + RVA+ + R QA  A+ D +
Sbjct: 2374 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2431

Query: 1332 --QRELEQLGRQL 1342
              +++ E++G +L
Sbjct: 2432 RFRKQAEEIGEKL 2444



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 164/750 (21%), Positives = 291/750 (38%), Gaps = 146/750 (19%)

Query: 639  VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690
            V  Q+  R+ ELE     LRY ++    L AW+++ + R +  +     D  +V  QL  
Sbjct: 1218 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1277

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
             + L + IE    K+E  +    Q   A +             Y   L + KA+L  + S
Sbjct: 1278 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1325

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY----SALMRELELKEKKIK 806
                   A K  +    +   +   D     + +T     Y    S  +R +E +E+++ 
Sbjct: 1326 ------PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLA 1378

Query: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
            E Q A +R           +   +AAL+ Q     QL    EAH +  A          +
Sbjct: 1379 EQQRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------Q 1412

Query: 867  AEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 926
            AE + ++LQ+ ++ +        V R E+   DAQ +K  + E    L  L + ++A +Q
Sbjct: 1413 AEREAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQ 1461

Query: 927  LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 986
             K R      R RL +       ++++   +       G  Q      L +   EA    
Sbjct: 1462 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK 1516

Query: 987  VCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 1046
                     ++ QE   RL  Q Q       Q  V++ S      ++ + +  R      
Sbjct: 1517 ---------RQAQEEAERLRRQVQDESQRKRQAEVELAS-----RVKAEAEAAR------ 1556

Query: 1047 FRTLKPEEQRQALHSLE-LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSL 1105
                   E+++AL +LE L  QA     ++A      +R + + E    +   Q  L++ 
Sbjct: 1557 -------EKQRALQALEELRLQA-----EEA------ERRLRQAEVER-ARQVQVALETA 1597

Query: 1106 EQGAQEESRCQRCISELKDIRLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQA 1164
            ++ A+ E + +R     K  +L+    E    V +LR     E A   AQ+ AE ++A+ 
Sbjct: 1598 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-----EEAERRAQQQAEAERARE 1652

Query: 1165 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1224
            E E   + + R   +A + L               L L   ++ Q +SL+    EK K  
Sbjct: 1653 EAE---RELERWQLKANEAL--------------RLRLQAEEVAQQKSLAQAEAEKQKEE 1695

Query: 1225 SL--VIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1278
            +     R  +  E+ +R    A +E  K+ Q    T  +  A +  L +LRA+ E  +  
Sbjct: 1696 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1755

Query: 1279 FDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDVRQRE 1334
               L +EL   Q       Q+  E + E+ + R  +  LL       +   + ++  ++ 
Sbjct: 1756 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815

Query: 1335 LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
            LE    + R   E A  L A  ++A+R+++
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQ 1845



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%)

Query: 693  GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
            GL + +    A+ E+  A  +    +P  R      LG+L+    ++ + S   L  L++
Sbjct: 1062 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1117

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803
            + S V   T+    +    EE++    +   T   + A K S   L  + E ++      
Sbjct: 1118 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1176

Query: 804  --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858
              +++  Q  G+RL +        VE ++   A L  +W  +L      +  L++     
Sbjct: 1177 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1236

Query: 859  QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918
            +++ +  +  G    LQ+A RR+               L D+Q  +EQL + +  L  + 
Sbjct: 1237 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1286

Query: 919  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978
            +  + V + +     +       + A+ DY ++++  +K     +  PA+    K    S
Sbjct: 1287 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1334

Query: 979  GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038
            GSE+ +     L     +     +T L +Q+   ++   +   + + L   Q      +L
Sbjct: 1335 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1389

Query: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098
                +    +    E   QA    E   +   +  Q+      E  + A+++  S     
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1449

Query: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144
            QQL QS E   Q ++R          R   E++ +RLQLEA E +       +  LR   
Sbjct: 1450 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1509

Query: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193
            +     K  A+E A+R+  Q      +K QAEVE   +  A   A  EK  AL     A 
Sbjct: 1510 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1565

Query: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230
              LR + E    +L Q                       ++S  A + EK   +   ++ 
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625

Query: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280
               A   LR   E+  + QA      E          L+A +A   +L+A+  AQQ +  
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1684

Query: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333
              + E    +E  ER  +R G+ + +  R RE   Q LE+ Q  LA+   +QR       
Sbjct: 1685 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1742

Query: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368
                 E EQ  +Q +   E    L      A +++++++A
Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 2363 bits (6124), Expect = 0.0
 Identities = 1193/1199 (99%), Positives = 1196/1199 (99%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
            DERDRVQKKT TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 38   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 97

Query: 231  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
            HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 98   HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 157

Query: 291  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
            MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 158  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 217

Query: 351  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
            NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 218  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 277

Query: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
            QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 278  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337

Query: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
            RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 338  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 397

Query: 531  VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
            VTKLQMEAGLCEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 398  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457

Query: 591  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 650
            TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 458  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 517

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARS
Sbjct: 518  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
            DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 578  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 638  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATV
Sbjct: 698  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
            TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 758  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQ
Sbjct: 818  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
            ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 878  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
            RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
            ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 998  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
            PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369
            RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%)

Query: 287  QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
            ++E   A+EK     QR ++  + LR     +   + RL  A + R + + + +    R 
Sbjct: 1522 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1573

Query: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403
               E   +  S AE+   + R L  E V V Q  E++             R    ++   
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 404  -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
              ++ANE L+LR Q     ++  L   +  +    A  E R     EE  +        +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1685

Query: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514
            + EL  +E +K R     Q  EG  Q  +L        L  E E G+    +LE E    
Sbjct: 1686 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739

Query: 515  ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544
                                           + R+E E     ++   +L+ EAG   E 
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799

Query: 545  LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587
              +A  L  L  +    R LA     ++  E ER L             K ++ I L   
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859

Query: 588  DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647
            + +  +  R  + E   RR  RL E+    + +   RL         Q+ + +   ++R+
Sbjct: 1860 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 1909

Query: 648  PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705
              L + TLR  + +   +   +   + A  G     +E +LG  R   +     + QA++
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 706  ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765
            E AR  + QL+       R+   R+    A    +++ R  +LE +   + A  +E   L
Sbjct: 1968 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 2024

Query: 766  NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
             E+ E+E      +  + + +      K  +++   +E EL++  +++ Q+  D+L  E 
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2083

Query: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
              AR   E  +                 EA ++      Q    V EAE   Q  +E  +
Sbjct: 2084 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126

Query: 880  RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935
             +     +A   R E   +  + AQ E+  L + +   + + K  K   Q L+ +     
Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186

Query: 936  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995
                L L       Q+E T H+ +   L    Q    +   ++   + V    F V    
Sbjct: 2187 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237

Query: 996  QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048
            +E+ +   R+EA+++AL+         + Q   +    +A ++ R  V    +   A  R
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2294

Query: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108
             L  E+  Q     E   +  ++  Q+A       RL AE E          LLQ  ++ 
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2338

Query: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159
            AQE++R          Q+   E +  +  LEA   R     +L +  E A     R+AE 
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2392

Query: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197
             +AQA  E   +   R   +AE++        LA  E      TL               
Sbjct: 2393 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449

Query: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252
               +ELE    KL+Q   L  +  E+++T+    +++ TQ  ++   + ++ L + +   
Sbjct: 2450 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2508

Query: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
                 +E  KA L++L     A+AQQ     LR+E +  Q+  E+ +QR      E  R 
Sbjct: 2509 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2558

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338
            +    + + R Q  L Q + ++R+ E+L
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2586



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%)

Query: 433  AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492
            AA E++R   + EE+       L+ +E E   ++A+  R++ +  +LE A ++ + ++  
Sbjct: 1527 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580

Query: 493  -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528
                       +E+   + HVA+       ER  Q ++E ER             L+  +
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640

Query: 529  RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588
             +  +LQ E    ++ L QA+A  Q +     A +  +R G+ E    +   +       
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1696

Query: 589  VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642
             + L +G   Q     + + RL       E+   +  E   RL+   AA   +  ++  +
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756

Query: 643  SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699
              + R E+E    S  R  ++  +  E+++ R+            EA+ G  R L +   
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1804

Query: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752
              +A  E A+    QL+       R    R+  +         +L   ++  L+  E+ +
Sbjct: 1805 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863

Query: 753  SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811
              +    ++  +   + EE+     +D    +   +K S S L R+  L E  +++ +  
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923

Query: 812  GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871
             + +L           SF+ A   +    L+L       ++ NA       +  E E   
Sbjct: 1924 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 1971

Query: 872  QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
            Q+    +E  RR+ + +R       E+  + A+  K  L E +  L    + A+ + +  
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 2028

Query: 929  PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982
             +  A  ++  L   A     Q E   H      K  E Q     + S    L      A
Sbjct: 2029 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086

Query: 983  AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
               +         +E +EA  R++A+ +A  +   +  V+    L  QS     Q  R+ 
Sbjct: 2087 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2130

Query: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
            + A    L+ E +++A    +   QA LR  Q A     + +  AE              
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2175

Query: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156
            Q+L Q AQ E        EL  +RLQLE  + +       + RL+     E AR+ +Q  
Sbjct: 2176 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2227

Query: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
             E    + ++E L K  AR+ AE  + L L +       L+ E E      E+   LS  
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286

Query: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271
              E  +   L    + +    AE++L+   + ++EA  + A    L+  K  + ++ R  
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2346

Query: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331
             E ++     L +E +G Q   E  +QR  E   E ER + RVA+ + R QA  A+ D +
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2404

Query: 1332 --QRELEQLGRQL 1342
              +++ E++G +L
Sbjct: 2405 RFRKQAEEIGEKL 2417



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 164/750 (21%), Positives = 291/750 (38%), Gaps = 146/750 (19%)

Query: 639  VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690
            V  Q+  R+ ELE     LRY ++    L AW+++ + R +  +     D  +V  QL  
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
             + L + IE    K+E  +    Q   A +             Y   L + KA+L  + S
Sbjct: 1251 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1298

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY----SALMRELELKEKKIK 806
                   A K  +    +   +   D     + +T     Y    S  +R +E +E+++ 
Sbjct: 1299 ------PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLA 1351

Query: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
            E Q A +R           +   +AAL+ Q     QL    EAH +  A          +
Sbjct: 1352 EQQRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------Q 1385

Query: 867  AEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 926
            AE + ++LQ+ ++ +        V R E+   DAQ +K  + E    L  L + ++A +Q
Sbjct: 1386 AEREAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQ 1434

Query: 927  LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 986
             K R      R RL +       ++++   +       G  Q      L +   EA    
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK 1489

Query: 987  VCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 1046
                     ++ QE   RL  Q Q       Q  V++ S      ++ + +  R      
Sbjct: 1490 ---------RQAQEEAERLRRQVQDESQRKRQAEVELAS-----RVKAEAEAAR------ 1529

Query: 1047 FRTLKPEEQRQALHSLE-LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSL 1105
                   E+++AL +LE L  QA     ++A      +R + + E    +   Q  L++ 
Sbjct: 1530 -------EKQRALQALEELRLQA-----EEA------ERRLRQAEVER-ARQVQVALETA 1570

Query: 1106 EQGAQEESRCQRCISELKDIRLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQA 1164
            ++ A+ E + +R     K  +L+    E    V +LR     E A   AQ+ AE ++A+ 
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-----EEAERRAQQQAEAERARE 1625

Query: 1165 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1224
            E E   + + R   +A + L               L L   ++ Q +SL+    EK K  
Sbjct: 1626 EAE---RELERWQLKANEAL--------------RLRLQAEEVAQQKSLAQAEAEKQKEE 1668

Query: 1225 SL--VIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1278
            +     R  +  E+ +R    A +E  K+ Q    T  +  A +  L +LRA+ E  +  
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1728

Query: 1279 FDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDVRQRE 1334
               L +EL   Q       Q+  E + E+ + R  +  LL       +   + ++  ++ 
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788

Query: 1335 LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
            LE    + R   E A  L A  ++A+R+++
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%)

Query: 693  GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
            GL + +    A+ E+  A  +    +P  R      LG+L+    ++ + S   L  L++
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1090

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803
            + S V   T+    +    EE++    +   T   + A K S   L  + E ++      
Sbjct: 1091 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1149

Query: 804  --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858
              +++  Q  G+RL +        VE ++   A L  +W  +L      +  L++     
Sbjct: 1150 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1209

Query: 859  QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918
            +++ +  +  G    LQ+A RR+               L D+Q  +EQL + +  L  + 
Sbjct: 1210 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1259

Query: 919  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978
            +  + V + +     +       + A+ DY ++++  +K     +  PA+    K    S
Sbjct: 1260 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1307

Query: 979  GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038
            GSE+ +     L     +     +T L +Q+   ++   +   + + L   Q      +L
Sbjct: 1308 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362

Query: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098
                +    +    E   QA    E   +   +  Q+      E  + A+++  S     
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422

Query: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144
            QQL QS E   Q ++R          R   E++ +RLQLEA E +       +  LR   
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482

Query: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193
            +     K  A+E A+R+  Q      +K QAEVE   +  A   A  EK  AL     A 
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1538

Query: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230
              LR + E    +L Q                       ++S  A + EK   +   ++ 
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598

Query: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280
               A   LR   E+  + QA      E          L+A +A   +L+A+  AQQ +  
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1657

Query: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333
              + E    +E  ER  +R G+ + +  R RE   Q LE+ Q  LA+   +QR       
Sbjct: 1658 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1715

Query: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368
                 E EQ  +Q +   E    L      A +++++++A
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 2363 bits (6124), Expect = 0.0
 Identities = 1193/1199 (99%), Positives = 1196/1199 (99%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
            DERDRVQKKT TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 42   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 101

Query: 231  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
            HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 102  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 161

Query: 291  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
            MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 162  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 221

Query: 351  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
            NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 222  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 281

Query: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
            QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 282  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 341

Query: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
            RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 342  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 401

Query: 531  VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
            VTKLQMEAGLCEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 402  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 461

Query: 591  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 650
            TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 462  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 521

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARS
Sbjct: 522  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
            DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 582  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 641

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 642  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 701

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATV
Sbjct: 702  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 761

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
            TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 762  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQ
Sbjct: 822  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 881

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
            ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 882  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 941

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
            RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 942  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1001

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
            ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 1002 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
            PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1062 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1181

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369
            RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1240



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%)

Query: 287  QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
            ++E   A+EK     QR ++  + LR     +   + RL  A + R + + + +    R 
Sbjct: 1526 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1577

Query: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403
               E   +  S AE+   + R L  E V V Q  E++             R    ++   
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637

Query: 404  -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
              ++ANE L+LR Q     ++  L   +  +    A  E R     EE  +        +
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1689

Query: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514
            + EL  +E +K R     Q  EG  Q  +L        L  E E G+    +LE E    
Sbjct: 1690 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1743

Query: 515  ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544
                                           + R+E E     ++   +L+ EAG   E 
Sbjct: 1744 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803

Query: 545  LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587
              +A  L  L  +    R LA     ++  E ER L             K ++ I L   
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863

Query: 588  DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647
            + +  +  R  + E   RR  RL E+    + +   RL         Q+ + +   ++R+
Sbjct: 1864 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 1913

Query: 648  PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705
              L + TLR  + +   +   +   + A  G     +E +LG  R   +     + QA++
Sbjct: 1914 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 1971

Query: 706  ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765
            E AR  + QL+       R+   R+    A    +++ R  +LE +   + A  +E   L
Sbjct: 1972 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 2028

Query: 766  NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
             E+ E+E      +  + + +      K  +++   +E EL++  +++ Q+  D+L  E 
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2087

Query: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
              AR   E  +                 EA ++      Q    V EAE   Q  +E  +
Sbjct: 2088 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2130

Query: 880  RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935
             +     +A   R E   +  + AQ E+  L + +   + + K  K   Q L+ +     
Sbjct: 2131 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2190

Query: 936  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995
                L L       Q+E T H+ +   L    Q    +   ++   + V    F V    
Sbjct: 2191 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2241

Query: 996  QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048
            +E+ +   R+EA+++AL+         + Q   +    +A ++ R  V    +   A  R
Sbjct: 2242 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2298

Query: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108
             L  E+  Q     E   +  ++  Q+A       RL AE E          LLQ  ++ 
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2342

Query: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159
            AQE++R          Q+   E +  +  LEA   R     +L +  E A     R+AE 
Sbjct: 2343 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2396

Query: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197
             +AQA  E   +   R   +AE++        LA  E      TL               
Sbjct: 2397 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2453

Query: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252
               +ELE    KL+Q   L  +  E+++T+    +++ TQ  ++   + ++ L + +   
Sbjct: 2454 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2512

Query: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
                 +E  KA L++L     A+AQQ     LR+E +  Q+  E+ +QR      E  R 
Sbjct: 2513 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2562

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338
            +    + + R Q  L Q + ++R+ E+L
Sbjct: 2563 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2590



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%)

Query: 433  AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492
            AA E++R   + EE+       L+ +E E   ++A+  R++ +  +LE A ++ + ++  
Sbjct: 1531 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584

Query: 493  -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528
                       +E+   + HVA+       ER  Q ++E ER             L+  +
Sbjct: 1585 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1644

Query: 529  RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588
             +  +LQ E    ++ L QA+A  Q +     A +  +R G+ E    +   +       
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1700

Query: 589  VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642
             + L +G   Q     + + RL       E+   +  E   RL+   AA   +  ++  +
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1760

Query: 643  SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699
              + R E+E    S  R  ++  +  E+++ R+            EA+ G  R L +   
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1808

Query: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752
              +A  E A+    QL+       R    R+  +         +L   ++  L+  E+ +
Sbjct: 1809 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867

Query: 753  SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811
              +    ++  +   + EE+     +D    +   +K S S L R+  L E  +++ +  
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927

Query: 812  GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871
             + +L           SF+ A   +    L+L       ++ NA       +  E E   
Sbjct: 1928 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 1975

Query: 872  QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
            Q+    +E  RR+ + +R       E+  + A+  K  L E +  L    + A+ + +  
Sbjct: 1976 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 2032

Query: 929  PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982
             +  A  ++  L   A     Q E   H      K  E Q     + S    L      A
Sbjct: 2033 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2090

Query: 983  AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
               +         +E +EA  R++A+ +A  +   +  V+    L  QS     Q  R+ 
Sbjct: 2091 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2134

Query: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
            + A    L+ E +++A    +   QA LR  Q A     + +  AE              
Sbjct: 2135 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2179

Query: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156
            Q+L Q AQ E        EL  +RLQLE  + +       + RL+     E AR+ +Q  
Sbjct: 2180 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2231

Query: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
             E    + ++E L K  AR+ AE  + L L +       L+ E E      E+   LS  
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2290

Query: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271
              E  +   L    + +    AE++L+   + ++EA  + A    L+  K  + ++ R  
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2350

Query: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331
             E ++     L +E +G Q   E  +QR  E   E ER + RVA+ + R QA  A+ D +
Sbjct: 2351 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2408

Query: 1332 --QRELEQLGRQL 1342
              +++ E++G +L
Sbjct: 2409 RFRKQAEEIGEKL 2421



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 164/750 (21%), Positives = 291/750 (38%), Gaps = 146/750 (19%)

Query: 639  VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690
            V  Q+  R+ ELE     LRY ++    L AW+++ + R +  +     D  +V  QL  
Sbjct: 1195 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1254

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
             + L + IE    K+E  +    Q   A +             Y   L + KA+L  + S
Sbjct: 1255 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1302

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY----SALMRELELKEKKIK 806
                   A K  +    +   +   D     + +T     Y    S  +R +E +E+++ 
Sbjct: 1303 ------PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLA 1355

Query: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
            E Q A +R           +   +AAL+ Q     QL    EAH +  A          +
Sbjct: 1356 EQQRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------Q 1389

Query: 867  AEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 926
            AE + ++LQ+ ++ +        V R E+   DAQ +K  + E    L  L + ++A +Q
Sbjct: 1390 AEREAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQ 1438

Query: 927  LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 986
             K R      R RL +       ++++   +       G  Q      L +   EA    
Sbjct: 1439 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK 1493

Query: 987  VCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 1046
                     ++ QE   RL  Q Q       Q  V++ S      ++ + +  R      
Sbjct: 1494 ---------RQAQEEAERLRRQVQDESQRKRQAEVELAS-----RVKAEAEAAR------ 1533

Query: 1047 FRTLKPEEQRQALHSLE-LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSL 1105
                   E+++AL +LE L  QA     ++A      +R + + E    +   Q  L++ 
Sbjct: 1534 -------EKQRALQALEELRLQA-----EEA------ERRLRQAEVER-ARQVQVALETA 1574

Query: 1106 EQGAQEESRCQRCISELKDIRLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQA 1164
            ++ A+ E + +R     K  +L+    E    V +LR     E A   AQ+ AE ++A+ 
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-----EEAERRAQQQAEAERARE 1629

Query: 1165 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1224
            E E   + + R   +A + L               L L   ++ Q +SL+    EK K  
Sbjct: 1630 EAE---RELERWQLKANEAL--------------RLRLQAEEVAQQKSLAQAEAEKQKEE 1672

Query: 1225 SL--VIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1278
            +     R  +  E+ +R    A +E  K+ Q    T  +  A +  L +LRA+ E  +  
Sbjct: 1673 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1732

Query: 1279 FDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDVRQRE 1334
               L +EL   Q       Q+  E + E+ + R  +  LL       +   + ++  ++ 
Sbjct: 1733 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1792

Query: 1335 LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
            LE    + R   E A  L A  ++A+R+++
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEEAKRQRQ 1822



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%)

Query: 693  GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
            GL + +    A+ E+  A  +    +P  R      LG+L+    ++ + S   L  L++
Sbjct: 1039 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1094

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803
            + S V   T+    +    EE++    +   T   + A K S   L  + E ++      
Sbjct: 1095 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1153

Query: 804  --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858
              +++  Q  G+RL +        VE ++   A L  +W  +L      +  L++     
Sbjct: 1154 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1213

Query: 859  QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918
            +++ +  +  G    LQ+A RR+               L D+Q  +EQL + +  L  + 
Sbjct: 1214 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1263

Query: 919  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978
            +  + V + +     +       + A+ DY ++++  +K     +  PA+    K    S
Sbjct: 1264 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1311

Query: 979  GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038
            GSE+ +     L     +     +T L +Q+   ++   +   + + L   Q      +L
Sbjct: 1312 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1366

Query: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098
                +    +    E   QA    E   +   +  Q+      E  + A+++  S     
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1426

Query: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144
            QQL QS E   Q ++R          R   E++ +RLQLEA E +       +  LR   
Sbjct: 1427 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1486

Query: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193
            +     K  A+E A+R+  Q      +K QAEVE   +  A   A  EK  AL     A 
Sbjct: 1487 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1542

Query: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230
              LR + E    +L Q                       ++S  A + EK   +   ++ 
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602

Query: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280
               A   LR   E+  + QA      E          L+A +A   +L+A+  AQQ +  
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1661

Query: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333
              + E    +E  ER  +R G+ + +  R RE   Q LE+ Q  LA+   +QR       
Sbjct: 1662 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1719

Query: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368
                 E EQ  +Q +   E    L      A +++++++A
Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1759


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 2363 bits (6124), Expect = 0.0
 Identities = 1193/1199 (99%), Positives = 1196/1199 (99%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
            DERDRVQKKT TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 38   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 97

Query: 231  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
            HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 98   HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 157

Query: 291  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
            MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 158  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 217

Query: 351  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
            NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 218  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 277

Query: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
            QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 278  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337

Query: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
            RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 338  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 397

Query: 531  VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
            VTKLQMEAGLCEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 398  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457

Query: 591  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 650
            TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 458  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 517

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARS
Sbjct: 518  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
            DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 578  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 638  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATV
Sbjct: 698  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
            TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 758  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQ
Sbjct: 818  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
            ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 878  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
            RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
            ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 998  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
            PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369
            RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%)

Query: 287  QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
            ++E   A+EK     QR ++  + LR     +   + RL  A + R + + + +    R 
Sbjct: 1522 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1573

Query: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403
               E   +  S AE+   + R L  E V V Q  E++             R    ++   
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633

Query: 404  -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
              ++ANE L+LR Q     ++  L   +  +    A  E R     EE  +        +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1685

Query: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514
            + EL  +E +K R     Q  EG  Q  +L        L  E E G+    +LE E    
Sbjct: 1686 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739

Query: 515  ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544
                                           + R+E E     ++   +L+ EAG   E 
Sbjct: 1740 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799

Query: 545  LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587
              +A  L  L  +    R LA     ++  E ER L             K ++ I L   
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859

Query: 588  DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647
            + +  +  R  + E   RR  RL E+    + +   RL         Q+ + +   ++R+
Sbjct: 1860 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 1909

Query: 648  PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705
              L + TLR  + +   +   +   + A  G     +E +LG  R   +     + QA++
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 1967

Query: 706  ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765
            E AR  + QL+       R+   R+    A    +++ R  +LE +   + A  +E   L
Sbjct: 1968 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 2024

Query: 766  NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
             E+ E+E      +  + + +      K  +++   +E EL++  +++ Q+  D+L  E 
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2083

Query: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
              AR   E  +                 EA ++      Q    V EAE   Q  +E  +
Sbjct: 2084 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126

Query: 880  RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935
             +     +A   R E   +  + AQ E+  L + +   + + K  K   Q L+ +     
Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2186

Query: 936  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995
                L L       Q+E T H+ +   L    Q    +   ++   + V    F V    
Sbjct: 2187 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2237

Query: 996  QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048
            +E+ +   R+EA+++AL+         + Q   +    +A ++ R  V    +   A  R
Sbjct: 2238 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2294

Query: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108
             L  E+  Q     E   +  ++  Q+A       RL AE E          LLQ  ++ 
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2338

Query: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159
            AQE++R          Q+   E +  +  LEA   R     +L +  E A     R+AE 
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2392

Query: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197
             +AQA  E   +   R   +AE++        LA  E      TL               
Sbjct: 2393 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449

Query: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252
               +ELE    KL+Q   L  +  E+++T+    +++ TQ  ++   + ++ L + +   
Sbjct: 2450 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2508

Query: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
                 +E  KA L++L     A+AQQ     LR+E +  Q+  E+ +QR      E  R 
Sbjct: 2509 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2558

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338
            +    + + R Q  L Q + ++R+ E+L
Sbjct: 2559 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2586



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%)

Query: 433  AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492
            AA E++R   + EE+       L+ +E E   ++A+  R++ +  +LE A ++ + ++  
Sbjct: 1527 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580

Query: 493  -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528
                       +E+   + HVA+       ER  Q ++E ER             L+  +
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640

Query: 529  RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588
             +  +LQ E    ++ L QA+A  Q +     A +  +R G+ E    +   +       
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1696

Query: 589  VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642
             + L +G   Q     + + RL       E+   +  E   RL+   AA   +  ++  +
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756

Query: 643  SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699
              + R E+E    S  R  ++  +  E+++ R+            EA+ G  R L +   
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1804

Query: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752
              +A  E A+    QL+       R    R+  +         +L   ++  L+  E+ +
Sbjct: 1805 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863

Query: 753  SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811
              +    ++  +   + EE+     +D    +   +K S S L R+  L E  +++ +  
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923

Query: 812  GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871
             + +L           SF+ A   +    L+L       ++ NA       +  E E   
Sbjct: 1924 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 1971

Query: 872  QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
            Q+    +E  RR+ + +R       E+  + A+  K  L E +  L    + A+ + +  
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 2028

Query: 929  PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982
             +  A  ++  L   A     Q E   H      K  E Q     + S    L      A
Sbjct: 2029 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086

Query: 983  AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
               +         +E +EA  R++A+ +A  +   +  V+    L  QS     Q  R+ 
Sbjct: 2087 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2130

Query: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
            + A    L+ E +++A    +   QA LR  Q A     + +  AE              
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2175

Query: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156
            Q+L Q AQ E        EL  +RLQLE  + +       + RL+     E AR+ +Q  
Sbjct: 2176 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2227

Query: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
             E    + ++E L K  AR+ AE  + L L +       L+ E E      E+   LS  
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286

Query: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271
              E  +   L    + +    AE++L+   + ++EA  + A    L+  K  + ++ R  
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2346

Query: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331
             E ++     L +E +G Q   E  +QR  E   E ER + RVA+ + R QA  A+ D +
Sbjct: 2347 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2404

Query: 1332 --QRELEQLGRQL 1342
              +++ E++G +L
Sbjct: 2405 RFRKQAEEIGEKL 2417



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 164/750 (21%), Positives = 291/750 (38%), Gaps = 146/750 (19%)

Query: 639  VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690
            V  Q+  R+ ELE     LRY ++    L AW+++ + R +  +     D  +V  QL  
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
             + L + IE    K+E  +    Q   A +             Y   L + KA+L  + S
Sbjct: 1251 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1298

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY----SALMRELELKEKKIK 806
                   A K  +    +   +   D     + +T     Y    S  +R +E +E+++ 
Sbjct: 1299 ------PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLA 1351

Query: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
            E Q A +R           +   +AAL+ Q     QL    EAH +  A          +
Sbjct: 1352 EQQRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------Q 1385

Query: 867  AEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 926
            AE + ++LQ+ ++ +        V R E+   DAQ +K  + E    L  L + ++A +Q
Sbjct: 1386 AEREAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQ 1434

Query: 927  LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 986
             K R      R RL +       ++++   +       G  Q      L +   EA    
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK 1489

Query: 987  VCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 1046
                     ++ QE   RL  Q Q       Q  V++ S      ++ + +  R      
Sbjct: 1490 ---------RQAQEEAERLRRQVQDESQRKRQAEVELAS-----RVKAEAEAAR------ 1529

Query: 1047 FRTLKPEEQRQALHSLE-LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSL 1105
                   E+++AL +LE L  QA     ++A      +R + + E    +   Q  L++ 
Sbjct: 1530 -------EKQRALQALEELRLQA-----EEA------ERRLRQAEVER-ARQVQVALETA 1570

Query: 1106 EQGAQEESRCQRCISELKDIRLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQA 1164
            ++ A+ E + +R     K  +L+    E    V +LR     E A   AQ+ AE ++A+ 
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-----EEAERRAQQQAEAERARE 1625

Query: 1165 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1224
            E E   + + R   +A + L               L L   ++ Q +SL+    EK K  
Sbjct: 1626 EAE---RELERWQLKANEAL--------------RLRLQAEEVAQQKSLAQAEAEKQKEE 1668

Query: 1225 SL--VIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1278
            +     R  +  E+ +R    A +E  K+ Q    T  +  A +  L +LRA+ E  +  
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1728

Query: 1279 FDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDVRQRE 1334
               L +EL   Q       Q+  E + E+ + R  +  LL       +   + ++  ++ 
Sbjct: 1729 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1788

Query: 1335 LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
            LE    + R   E A  L A  ++A+R+++
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%)

Query: 693  GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
            GL + +    A+ E+  A  +    +P  R      LG+L+    ++ + S   L  L++
Sbjct: 1035 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1090

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803
            + S V   T+    +    EE++    +   T   + A K S   L  + E ++      
Sbjct: 1091 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1149

Query: 804  --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858
              +++  Q  G+RL +        VE ++   A L  +W  +L      +  L++     
Sbjct: 1150 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1209

Query: 859  QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918
            +++ +  +  G    LQ+A RR+               L D+Q  +EQL + +  L  + 
Sbjct: 1210 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1259

Query: 919  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978
            +  + V + +     +       + A+ DY ++++  +K     +  PA+    K    S
Sbjct: 1260 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1307

Query: 979  GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038
            GSE+ +     L     +     +T L +Q+   ++   +   + + L   Q      +L
Sbjct: 1308 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1362

Query: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098
                +    +    E   QA    E   +   +  Q+      E  + A+++  S     
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422

Query: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144
            QQL QS E   Q ++R          R   E++ +RLQLEA E +       +  LR   
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482

Query: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193
            +     K  A+E A+R+  Q      +K QAEVE   +  A   A  EK  AL     A 
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1538

Query: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230
              LR + E    +L Q                       ++S  A + EK   +   ++ 
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598

Query: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280
               A   LR   E+  + QA      E          L+A +A   +L+A+  AQQ +  
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1657

Query: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333
              + E    +E  ER  +R G+ + +  R RE   Q LE+ Q  LA+   +QR       
Sbjct: 1658 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1715

Query: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368
                 E EQ  +Q +   E    L      A +++++++A
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 2363 bits (6124), Expect = 0.0
 Identities = 1193/1199 (99%), Positives = 1196/1199 (99%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
            DERDRVQKKT TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 6    DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 65

Query: 231  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
            HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 66   HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 125

Query: 291  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
            MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 126  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 185

Query: 351  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
            NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 186  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 245

Query: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
            QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 246  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 305

Query: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
            RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 306  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 365

Query: 531  VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
            VTKLQMEAGLCEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 366  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 425

Query: 591  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 650
            TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 426  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 485

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARS
Sbjct: 486  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
            DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 546  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 605

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 606  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 665

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATV
Sbjct: 666  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 725

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
            TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 726  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQ
Sbjct: 786  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 845

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
            ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 846  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 905

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
            RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 906  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 965

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
            ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 966  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
            PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1026 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1145

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369
            RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1204



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%)

Query: 287  QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
            ++E   A+EK     QR ++  + LR     +   + RL  A + R + + + +    R 
Sbjct: 1490 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1541

Query: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403
               E   +  S AE+   + R L  E V V Q  E++             R    ++   
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601

Query: 404  -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
              ++ANE L+LR Q     ++  L   +  +    A  E R     EE  +        +
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1653

Query: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514
            + EL  +E +K R     Q  EG  Q  +L        L  E E G+    +LE E    
Sbjct: 1654 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1707

Query: 515  ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544
                                           + R+E E     ++   +L+ EAG   E 
Sbjct: 1708 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767

Query: 545  LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587
              +A  L  L  +    R LA     ++  E ER L             K ++ I L   
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1827

Query: 588  DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647
            + +  +  R  + E   RR  RL E+    + +   RL         Q+ + +   ++R+
Sbjct: 1828 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 1877

Query: 648  PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705
              L + TLR  + +   +   +   + A  G     +E +LG  R   +     + QA++
Sbjct: 1878 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 1935

Query: 706  ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765
            E AR  + QL+       R+   R+    A    +++ R  +LE +   + A  +E   L
Sbjct: 1936 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 1992

Query: 766  NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
             E+ E+E      +  + + +      K  +++   +E EL++  +++ Q+  D+L  E 
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2051

Query: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
              AR   E  +                 EA ++      Q    V EAE   Q  +E  +
Sbjct: 2052 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2094

Query: 880  RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935
             +     +A   R E   +  + AQ E+  L + +   + + K  K   Q L+ +     
Sbjct: 2095 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2154

Query: 936  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995
                L L       Q+E T H+ +   L    Q    +   ++   + V    F V    
Sbjct: 2155 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2205

Query: 996  QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048
            +E+ +   R+EA+++AL+         + Q   +    +A ++ R  V    +   A  R
Sbjct: 2206 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2262

Query: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108
             L  E+  Q     E   +  ++  Q+A       RL AE E          LLQ  ++ 
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2306

Query: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159
            AQE++R          Q+   E +  +  LEA   R     +L +  E A     R+AE 
Sbjct: 2307 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2360

Query: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197
             +AQA  E   +   R   +AE++        LA  E      TL               
Sbjct: 2361 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2417

Query: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252
               +ELE    KL+Q   L  +  E+++T+    +++ TQ  ++   + ++ L + +   
Sbjct: 2418 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2476

Query: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
                 +E  KA L++L     A+AQQ     LR+E +  Q+  E+ +QR      E  R 
Sbjct: 2477 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2526

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338
            +    + + R Q  L Q + ++R+ E+L
Sbjct: 2527 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2554



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%)

Query: 433  AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492
            AA E++R   + EE+       L+ +E E   ++A+  R++ +  +LE A ++ + ++  
Sbjct: 1495 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548

Query: 493  -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528
                       +E+   + HVA+       ER  Q ++E ER             L+  +
Sbjct: 1549 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1608

Query: 529  RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588
             +  +LQ E    ++ L QA+A  Q +     A +  +R G+ E    +   +       
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1664

Query: 589  VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642
             + L +G   Q     + + RL       E+   +  E   RL+   AA   +  ++  +
Sbjct: 1665 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1724

Query: 643  SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699
              + R E+E    S  R  ++  +  E+++ R+            EA+ G  R L +   
Sbjct: 1725 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1772

Query: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752
              +A  E A+    QL+       R    R+  +         +L   ++  L+  E+ +
Sbjct: 1773 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831

Query: 753  SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811
              +    ++  +   + EE+     +D    +   +K S S L R+  L E  +++ +  
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1891

Query: 812  GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871
             + +L           SF+ A   +    L+L       ++ NA       +  E E   
Sbjct: 1892 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 1939

Query: 872  QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
            Q+    +E  RR+ + +R       E+  + A+  K  L E +  L    + A+ + +  
Sbjct: 1940 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 1996

Query: 929  PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982
             +  A  ++  L   A     Q E   H      K  E Q     + S    L      A
Sbjct: 1997 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2054

Query: 983  AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
               +         +E +EA  R++A+ +A  +   +  V+    L  QS     Q  R+ 
Sbjct: 2055 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2098

Query: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
            + A    L+ E +++A    +   QA LR  Q A     + +  AE              
Sbjct: 2099 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2143

Query: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156
            Q+L Q AQ E        EL  +RLQLE  + +       + RL+     E AR+ +Q  
Sbjct: 2144 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2195

Query: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
             E    + ++E L K  AR+ AE  + L L +       L+ E E      E+   LS  
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2254

Query: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271
              E  +   L    + +    AE++L+   + ++EA  + A    L+  K  + ++ R  
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2314

Query: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331
             E ++     L +E +G Q   E  +QR  E   E ER + RVA+ + R QA  A+ D +
Sbjct: 2315 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2372

Query: 1332 --QRELEQLGRQL 1342
              +++ E++G +L
Sbjct: 2373 RFRKQAEEIGEKL 2385



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 164/750 (21%), Positives = 291/750 (38%), Gaps = 146/750 (19%)

Query: 639  VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690
            V  Q+  R+ ELE     LRY ++    L AW+++ + R +  +     D  +V  QL  
Sbjct: 1159 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1218

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
             + L + IE    K+E  +    Q   A +             Y   L + KA+L  + S
Sbjct: 1219 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1266

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY----SALMRELELKEKKIK 806
                   A K  +    +   +   D     + +T     Y    S  +R +E +E+++ 
Sbjct: 1267 ------PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLA 1319

Query: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
            E Q A +R           +   +AAL+ Q     QL    EAH +  A          +
Sbjct: 1320 EQQRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------Q 1353

Query: 867  AEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 926
            AE + ++LQ+ ++ +        V R E+   DAQ +K  + E    L  L + ++A +Q
Sbjct: 1354 AEREAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQ 1402

Query: 927  LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 986
             K R      R RL +       ++++   +       G  Q      L +   EA    
Sbjct: 1403 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK 1457

Query: 987  VCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 1046
                     ++ QE   RL  Q Q       Q  V++ S      ++ + +  R      
Sbjct: 1458 ---------RQAQEEAERLRRQVQDESQRKRQAEVELAS-----RVKAEAEAAR------ 1497

Query: 1047 FRTLKPEEQRQALHSLE-LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSL 1105
                   E+++AL +LE L  QA     ++A      +R + + E    +   Q  L++ 
Sbjct: 1498 -------EKQRALQALEELRLQA-----EEA------ERRLRQAEVER-ARQVQVALETA 1538

Query: 1106 EQGAQEESRCQRCISELKDIRLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQA 1164
            ++ A+ E + +R     K  +L+    E    V +LR     E A   AQ+ AE ++A+ 
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-----EEAERRAQQQAEAERARE 1593

Query: 1165 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1224
            E E   + + R   +A + L               L L   ++ Q +SL+    EK K  
Sbjct: 1594 EAE---RELERWQLKANEAL--------------RLRLQAEEVAQQKSLAQAEAEKQKEE 1636

Query: 1225 SL--VIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1278
            +     R  +  E+ +R    A +E  K+ Q    T  +  A +  L +LRA+ E  +  
Sbjct: 1637 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1696

Query: 1279 FDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDVRQRE 1334
               L +EL   Q       Q+  E + E+ + R  +  LL       +   + ++  ++ 
Sbjct: 1697 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1756

Query: 1335 LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
            LE    + R   E A  L A  ++A+R+++
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEEAKRQRQ 1786



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%)

Query: 693  GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
            GL + +    A+ E+  A  +    +P  R      LG+L+    ++ + S   L  L++
Sbjct: 1003 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1058

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803
            + S V   T+    +    EE++    +   T   + A K S   L  + E ++      
Sbjct: 1059 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1117

Query: 804  --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858
              +++  Q  G+RL +        VE ++   A L  +W  +L      +  L++     
Sbjct: 1118 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1177

Query: 859  QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918
            +++ +  +  G    LQ+A RR+               L D+Q  +EQL + +  L  + 
Sbjct: 1178 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1227

Query: 919  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978
            +  + V + +     +       + A+ DY ++++  +K     +  PA+    K    S
Sbjct: 1228 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1275

Query: 979  GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038
            GSE+ +     L     +     +T L +Q+   ++   +   + + L   Q      +L
Sbjct: 1276 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1330

Query: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098
                +    +    E   QA    E   +   +  Q+      E  + A+++  S     
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1390

Query: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144
            QQL QS E   Q ++R          R   E++ +RLQLEA E +       +  LR   
Sbjct: 1391 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1450

Query: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193
            +     K  A+E A+R+  Q      +K QAEVE   +  A   A  EK  AL     A 
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1506

Query: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230
              LR + E    +L Q                       ++S  A + EK   +   ++ 
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566

Query: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280
               A   LR   E+  + QA      E          L+A +A   +L+A+  AQQ +  
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1625

Query: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333
              + E    +E  ER  +R G+ + +  R RE   Q LE+ Q  LA+   +QR       
Sbjct: 1626 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1683

Query: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368
                 E EQ  +Q +   E    L      A +++++++A
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1723


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 2363 bits (6124), Expect = 0.0
 Identities = 1193/1199 (99%), Positives = 1196/1199 (99%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
            DERDRVQKKT TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 16   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 75

Query: 231  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
            HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 76   HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 135

Query: 291  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
            MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 136  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 195

Query: 351  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
            NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 196  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 255

Query: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
            QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 256  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 315

Query: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
            RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 316  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 375

Query: 531  VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
            VTKLQMEAGLCEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 376  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 435

Query: 591  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 650
            TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 436  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 495

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARS
Sbjct: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
            DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATV
Sbjct: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
            TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQ
Sbjct: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
            ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
            RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
            ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
            PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369
            RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%)

Query: 287  QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
            ++E   A+EK     QR ++  + LR     +   + RL  A + R + + + +    R 
Sbjct: 1500 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1551

Query: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403
               E   +  S AE+   + R L  E V V Q  E++             R    ++   
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611

Query: 404  -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
              ++ANE L+LR Q     ++  L   +  +    A  E R     EE  +        +
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1663

Query: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514
            + EL  +E +K R     Q  EG  Q  +L        L  E E G+    +LE E    
Sbjct: 1664 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717

Query: 515  ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544
                                           + R+E E     ++   +L+ EAG   E 
Sbjct: 1718 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777

Query: 545  LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587
              +A  L  L  +    R LA     ++  E ER L             K ++ I L   
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1837

Query: 588  DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647
            + +  +  R  + E   RR  RL E+    + +   RL         Q+ + +   ++R+
Sbjct: 1838 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 1887

Query: 648  PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705
              L + TLR  + +   +   +   + A  G     +E +LG  R   +     + QA++
Sbjct: 1888 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 1945

Query: 706  ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765
            E AR  + QL+       R+   R+    A    +++ R  +LE +   + A  +E   L
Sbjct: 1946 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 2002

Query: 766  NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
             E+ E+E      +  + + +      K  +++   +E EL++  +++ Q+  D+L  E 
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2061

Query: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
              AR   E  +                 EA ++      Q    V EAE   Q  +E  +
Sbjct: 2062 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2104

Query: 880  RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935
             +     +A   R E   +  + AQ E+  L + +   + + K  K   Q L+ +     
Sbjct: 2105 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2164

Query: 936  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995
                L L       Q+E T H+ +   L    Q    +   ++   + V    F V    
Sbjct: 2165 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2215

Query: 996  QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048
            +E+ +   R+EA+++AL+         + Q   +    +A ++ R  V    +   A  R
Sbjct: 2216 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2272

Query: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108
             L  E+  Q     E   +  ++  Q+A       RL AE E          LLQ  ++ 
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2316

Query: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159
            AQE++R          Q+   E +  +  LEA   R     +L +  E A     R+AE 
Sbjct: 2317 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2370

Query: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197
             +AQA  E   +   R   +AE++        LA  E      TL               
Sbjct: 2371 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2427

Query: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252
               +ELE    KL+Q   L  +  E+++T+    +++ TQ  ++   + ++ L + +   
Sbjct: 2428 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2486

Query: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
                 +E  KA L++L     A+AQQ     LR+E +  Q+  E+ +QR      E  R 
Sbjct: 2487 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2536

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338
            +    + + R Q  L Q + ++R+ E+L
Sbjct: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2564



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%)

Query: 433  AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492
            AA E++R   + EE+       L+ +E E   ++A+  R++ +  +LE A ++ + ++  
Sbjct: 1505 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558

Query: 493  -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528
                       +E+   + HVA+       ER  Q ++E ER             L+  +
Sbjct: 1559 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1618

Query: 529  RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588
             +  +LQ E    ++ L QA+A  Q +     A +  +R G+ E    +   +       
Sbjct: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1674

Query: 589  VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642
             + L +G   Q     + + RL       E+   +  E   RL+   AA   +  ++  +
Sbjct: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1734

Query: 643  SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699
              + R E+E    S  R  ++  +  E+++ R+            EA+ G  R L +   
Sbjct: 1735 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1782

Query: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752
              +A  E A+    QL+       R    R+  +         +L   ++  L+  E+ +
Sbjct: 1783 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841

Query: 753  SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811
              +    ++  +   + EE+     +D    +   +K S S L R+  L E  +++ +  
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901

Query: 812  GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871
             + +L           SF+ A   +    L+L       ++ NA       +  E E   
Sbjct: 1902 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 1949

Query: 872  QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
            Q+    +E  RR+ + +R       E+  + A+  K  L E +  L    + A+ + +  
Sbjct: 1950 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 2006

Query: 929  PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982
             +  A  ++  L   A     Q E   H      K  E Q     + S    L      A
Sbjct: 2007 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2064

Query: 983  AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
               +         +E +EA  R++A+ +A  +   +  V+    L  QS     Q  R+ 
Sbjct: 2065 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2108

Query: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
            + A    L+ E +++A    +   QA LR  Q A     + +  AE              
Sbjct: 2109 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2153

Query: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156
            Q+L Q AQ E        EL  +RLQLE  + +       + RL+     E AR+ +Q  
Sbjct: 2154 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2205

Query: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
             E    + ++E L K  AR+ AE  + L L +       L+ E E      E+   LS  
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2264

Query: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271
              E  +   L    + +    AE++L+   + ++EA  + A    L+  K  + ++ R  
Sbjct: 2265 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2324

Query: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331
             E ++     L +E +G Q   E  +QR  E   E ER + RVA+ + R QA  A+ D +
Sbjct: 2325 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2382

Query: 1332 --QRELEQLGRQL 1342
              +++ E++G +L
Sbjct: 2383 RFRKQAEEIGEKL 2395



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 164/750 (21%), Positives = 291/750 (38%), Gaps = 146/750 (19%)

Query: 639  VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690
            V  Q+  R+ ELE     LRY ++    L AW+++ + R +  +     D  +V  QL  
Sbjct: 1169 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1228

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
             + L + IE    K+E  +    Q   A +             Y   L + KA+L  + S
Sbjct: 1229 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1276

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY----SALMRELELKEKKIK 806
                   A K  +    +   +   D     + +T     Y    S  +R +E +E+++ 
Sbjct: 1277 ------PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLA 1329

Query: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
            E Q A +R           +   +AAL+ Q     QL    EAH +  A          +
Sbjct: 1330 EQQRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------Q 1363

Query: 867  AEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 926
            AE + ++LQ+ ++ +        V R E+   DAQ +K  + E    L  L + ++A +Q
Sbjct: 1364 AEREAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQ 1412

Query: 927  LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 986
             K R      R RL +       ++++   +       G  Q      L +   EA    
Sbjct: 1413 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK 1467

Query: 987  VCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 1046
                     ++ QE   RL  Q Q       Q  V++ S      ++ + +  R      
Sbjct: 1468 ---------RQAQEEAERLRRQVQDESQRKRQAEVELAS-----RVKAEAEAAR------ 1507

Query: 1047 FRTLKPEEQRQALHSLE-LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSL 1105
                   E+++AL +LE L  QA     ++A      +R + + E    +   Q  L++ 
Sbjct: 1508 -------EKQRALQALEELRLQA-----EEA------ERRLRQAEVER-ARQVQVALETA 1548

Query: 1106 EQGAQEESRCQRCISELKDIRLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQA 1164
            ++ A+ E + +R     K  +L+    E    V +LR     E A   AQ+ AE ++A+ 
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-----EEAERRAQQQAEAERARE 1603

Query: 1165 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1224
            E E   + + R   +A + L               L L   ++ Q +SL+    EK K  
Sbjct: 1604 EAE---RELERWQLKANEAL--------------RLRLQAEEVAQQKSLAQAEAEKQKEE 1646

Query: 1225 SL--VIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1278
            +     R  +  E+ +R    A +E  K+ Q    T  +  A +  L +LRA+ E  +  
Sbjct: 1647 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1706

Query: 1279 FDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDVRQRE 1334
               L +EL   Q       Q+  E + E+ + R  +  LL       +   + ++  ++ 
Sbjct: 1707 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1766

Query: 1335 LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
            LE    + R   E A  L A  ++A+R+++
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQ 1796



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%)

Query: 693  GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
            GL + +    A+ E+  A  +    +P  R      LG+L+    ++ + S   L  L++
Sbjct: 1013 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1068

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803
            + S V   T+    +    EE++    +   T   + A K S   L  + E ++      
Sbjct: 1069 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1127

Query: 804  --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858
              +++  Q  G+RL +        VE ++   A L  +W  +L      +  L++     
Sbjct: 1128 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1187

Query: 859  QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918
            +++ +  +  G    LQ+A RR+               L D+Q  +EQL + +  L  + 
Sbjct: 1188 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1237

Query: 919  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978
            +  + V + +     +       + A+ DY ++++  +K     +  PA+    K    S
Sbjct: 1238 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1285

Query: 979  GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038
            GSE+ +     L     +     +T L +Q+   ++   +   + + L   Q      +L
Sbjct: 1286 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340

Query: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098
                +    +    E   QA    E   +   +  Q+      E  + A+++  S     
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1400

Query: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144
            QQL QS E   Q ++R          R   E++ +RLQLEA E +       +  LR   
Sbjct: 1401 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1460

Query: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193
            +     K  A+E A+R+  Q      +K QAEVE   +  A   A  EK  AL     A 
Sbjct: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1516

Query: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230
              LR + E    +L Q                       ++S  A + EK   +   ++ 
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576

Query: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280
               A   LR   E+  + QA      E          L+A +A   +L+A+  AQQ +  
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1635

Query: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333
              + E    +E  ER  +R G+ + +  R RE   Q LE+ Q  LA+   +QR       
Sbjct: 1636 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1693

Query: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368
                 E EQ  +Q +   E    L      A +++++++A
Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 2363 bits (6124), Expect = 0.0
 Identities = 1193/1199 (99%), Positives = 1196/1199 (99%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
            DERDRVQKKT TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 24   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 83

Query: 231  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
            HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 84   HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 143

Query: 291  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
            MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 144  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 203

Query: 351  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
            NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 204  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 263

Query: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
            QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 264  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 323

Query: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
            RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 324  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 383

Query: 531  VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
            VTKLQMEAGLCEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 384  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 443

Query: 591  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 650
            TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 444  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 503

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARS
Sbjct: 504  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
            DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 564  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 623

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 624  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 683

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATV
Sbjct: 684  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 743

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
            TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 744  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQ
Sbjct: 804  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 863

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
            ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 864  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 923

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
            RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 924  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 983

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
            ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 984  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
            PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1044 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1163

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369
            RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1222



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%)

Query: 287  QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
            ++E   A+EK     QR ++  + LR     +   + RL  A + R + + + +    R 
Sbjct: 1508 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1559

Query: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403
               E   +  S AE+   + R L  E V V Q  E++             R    ++   
Sbjct: 1560 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619

Query: 404  -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
              ++ANE L+LR Q     ++  L   +  +    A  E R     EE  +        +
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1671

Query: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514
            + EL  +E +K R     Q  EG  Q  +L        L  E E G+    +LE E    
Sbjct: 1672 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1725

Query: 515  ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544
                                           + R+E E     ++   +L+ EAG   E 
Sbjct: 1726 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785

Query: 545  LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587
              +A  L  L  +    R LA     ++  E ER L             K ++ I L   
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1845

Query: 588  DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647
            + +  +  R  + E   RR  RL E+    + +   RL         Q+ + +   ++R+
Sbjct: 1846 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 1895

Query: 648  PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705
              L + TLR  + +   +   +   + A  G     +E +LG  R   +     + QA++
Sbjct: 1896 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 1953

Query: 706  ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765
            E AR  + QL+       R+   R+    A    +++ R  +LE +   + A  +E   L
Sbjct: 1954 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 2010

Query: 766  NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
             E+ E+E      +  + + +      K  +++   +E EL++  +++ Q+  D+L  E 
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2069

Query: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
              AR   E  +                 EA ++      Q    V EAE   Q  +E  +
Sbjct: 2070 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2112

Query: 880  RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935
             +     +A   R E   +  + AQ E+  L + +   + + K  K   Q L+ +     
Sbjct: 2113 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2172

Query: 936  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995
                L L       Q+E T H+ +   L    Q    +   ++   + V    F V    
Sbjct: 2173 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2223

Query: 996  QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048
            +E+ +   R+EA+++AL+         + Q   +    +A ++ R  V    +   A  R
Sbjct: 2224 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2280

Query: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108
             L  E+  Q     E   +  ++  Q+A       RL AE E          LLQ  ++ 
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2324

Query: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159
            AQE++R          Q+   E +  +  LEA   R     +L +  E A     R+AE 
Sbjct: 2325 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2378

Query: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197
             +AQA  E   +   R   +AE++        LA  E      TL               
Sbjct: 2379 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2435

Query: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252
               +ELE    KL+Q   L  +  E+++T+    +++ TQ  ++   + ++ L + +   
Sbjct: 2436 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2494

Query: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
                 +E  KA L++L     A+AQQ     LR+E +  Q+  E+ +QR      E  R 
Sbjct: 2495 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2544

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338
            +    + + R Q  L Q + ++R+ E+L
Sbjct: 2545 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2572



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%)

Query: 433  AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492
            AA E++R   + EE+       L+ +E E   ++A+  R++ +  +LE A ++ + ++  
Sbjct: 1513 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566

Query: 493  -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528
                       +E+   + HVA+       ER  Q ++E ER             L+  +
Sbjct: 1567 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1626

Query: 529  RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588
             +  +LQ E    ++ L QA+A  Q +     A +  +R G+ E    +   +       
Sbjct: 1627 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1682

Query: 589  VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642
             + L +G   Q     + + RL       E+   +  E   RL+   AA   +  ++  +
Sbjct: 1683 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1742

Query: 643  SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699
              + R E+E    S  R  ++  +  E+++ R+            EA+ G  R L +   
Sbjct: 1743 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1790

Query: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752
              +A  E A+    QL+       R    R+  +         +L   ++  L+  E+ +
Sbjct: 1791 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849

Query: 753  SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811
              +    ++  +   + EE+     +D    +   +K S S L R+  L E  +++ +  
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909

Query: 812  GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871
             + +L           SF+ A   +    L+L       ++ NA       +  E E   
Sbjct: 1910 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 1957

Query: 872  QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
            Q+    +E  RR+ + +R       E+  + A+  K  L E +  L    + A+ + +  
Sbjct: 1958 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 2014

Query: 929  PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982
             +  A  ++  L   A     Q E   H      K  E Q     + S    L      A
Sbjct: 2015 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2072

Query: 983  AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
               +         +E +EA  R++A+ +A  +   +  V+    L  QS     Q  R+ 
Sbjct: 2073 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2116

Query: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
            + A    L+ E +++A    +   QA LR  Q A     + +  AE              
Sbjct: 2117 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2161

Query: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156
            Q+L Q AQ E        EL  +RLQLE  + +       + RL+     E AR+ +Q  
Sbjct: 2162 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2213

Query: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
             E    + ++E L K  AR+ AE  + L L +       L+ E E      E+   LS  
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2272

Query: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271
              E  +   L    + +    AE++L+   + ++EA  + A    L+  K  + ++ R  
Sbjct: 2273 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2332

Query: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331
             E ++     L +E +G Q   E  +QR  E   E ER + RVA+ + R QA  A+ D +
Sbjct: 2333 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2390

Query: 1332 --QRELEQLGRQL 1342
              +++ E++G +L
Sbjct: 2391 RFRKQAEEIGEKL 2403



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 164/750 (21%), Positives = 291/750 (38%), Gaps = 146/750 (19%)

Query: 639  VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690
            V  Q+  R+ ELE     LRY ++    L AW+++ + R +  +     D  +V  QL  
Sbjct: 1177 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1236

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
             + L + IE    K+E  +    Q   A +             Y   L + KA+L  + S
Sbjct: 1237 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1284

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY----SALMRELELKEKKIK 806
                   A K  +    +   +   D     + +T     Y    S  +R +E +E+++ 
Sbjct: 1285 ------PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLA 1337

Query: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
            E Q A +R           +   +AAL+ Q     QL    EAH +  A          +
Sbjct: 1338 EQQRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------Q 1371

Query: 867  AEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ 926
            AE + ++LQ+ ++ +        V R E+   DAQ +K  + E    L  L + ++A +Q
Sbjct: 1372 AEREAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQ 1420

Query: 927  LKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPS 986
             K R      R RL +       ++++   +       G  Q      L +   EA    
Sbjct: 1421 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK 1475

Query: 987  VCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLAT 1046
                     ++ QE   RL  Q Q       Q  V++ S      ++ + +  R      
Sbjct: 1476 ---------RQAQEEAERLRRQVQDESQRKRQAEVELAS-----RVKAEAEAAR------ 1515

Query: 1047 FRTLKPEEQRQALHSLE-LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSL 1105
                   E+++AL +LE L  QA     ++A      +R + + E    +   Q  L++ 
Sbjct: 1516 -------EKQRALQALEELRLQA-----EEA------ERRLRQAEVER-ARQVQVALETA 1556

Query: 1106 EQGAQEESRCQRCISELKDIRLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQA 1164
            ++ A+ E + +R     K  +L+    E    V +LR     E A   AQ+ AE ++A+ 
Sbjct: 1557 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR-----EEAERRAQQQAEAERARE 1611

Query: 1165 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1224
            E E   + + R   +A + L               L L   ++ Q +SL+    EK K  
Sbjct: 1612 EAE---RELERWQLKANEAL--------------RLRLQAEEVAQQKSLAQAEAEKQKEE 1654

Query: 1225 SL--VIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPT 1278
            +     R  +  E+ +R    A +E  K+ Q    T  +  A +  L +LRA+ E  +  
Sbjct: 1655 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1714

Query: 1279 FDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDVRQRE 1334
               L +EL   Q       Q+  E + E+ + R  +  LL       +   + ++  ++ 
Sbjct: 1715 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1774

Query: 1335 LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
            LE    + R   E A  L A  ++A+R+++
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEEAKRQRQ 1804



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%)

Query: 693  GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750
            GL + +    A+ E+  A  +    +P  R      LG+L+    ++ + S   L  L++
Sbjct: 1021 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1076

Query: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803
            + S V   T+    +    EE++    +   T   + A K S   L  + E ++      
Sbjct: 1077 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1135

Query: 804  --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858
              +++  Q  G+RL +        VE ++   A L  +W  +L      +  L++     
Sbjct: 1136 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1195

Query: 859  QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918
            +++ +  +  G    LQ+A RR+               L D+Q  +EQL + +  L  + 
Sbjct: 1196 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1245

Query: 919  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978
            +  + V + +     +       + A+ DY ++++  +K     +  PA+    K    S
Sbjct: 1246 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1293

Query: 979  GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038
            GSE+ +     L     +     +T L +Q+   ++   +   + + L   Q      +L
Sbjct: 1294 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1348

Query: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098
                +    +    E   QA    E   +   +  Q+      E  + A+++  S     
Sbjct: 1349 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1408

Query: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144
            QQL QS E   Q ++R          R   E++ +RLQLEA E +       +  LR   
Sbjct: 1409 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1468

Query: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193
            +     K  A+E A+R+  Q      +K QAEVE   +  A   A  EK  AL     A 
Sbjct: 1469 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1524

Query: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230
              LR + E    +L Q                       ++S  A + EK   +   ++ 
Sbjct: 1525 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1584

Query: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280
               A   LR   E+  + QA      E          L+A +A   +L+A+  AQQ +  
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1643

Query: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333
              + E    +E  ER  +R G+ + +  R RE   Q LE+ Q  LA+   +QR       
Sbjct: 1644 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1701

Query: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368
                 E EQ  +Q +   E    L      A +++++++A
Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1741


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score = 1142 bits (2954), Expect = 0.0
 Identities = 586/1230 (47%), Positives = 835/1230 (67%), Gaps = 34/1230 (2%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
            DERDRVQKKT TKWVNKHL+K ++HI+DLYEDLRDGHNLISLLEVLSG  LPREKGRMRF
Sbjct: 74   DERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRF 133

Query: 231  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
            H+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI +SG+S D
Sbjct: 134  HRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGD 193

Query: 291  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
            M+AKEKLLLW+Q++  GY G++C NF+S W DG++FNA+IHR++P L+DM +V  Q+N E
Sbjct: 194  MSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRE 253

Query: 351  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
            NL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA P+VP+  +G+ A E+
Sbjct: 254  NLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEV 312

Query: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
              RWQEY+  V  L+ W++ HT    ++ FP +  E++ L++Q++ FKE E+ AKE +K 
Sbjct: 313  DSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKG 372

Query: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
            R + +Y+ LE  ++ G++K+P GYHP DVE+EWGKL + +LEREK LR   ERLE L +I
Sbjct: 373  RIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQI 432

Query: 531  VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
              K+Q  A  CEE+L  A   LQ+D   L +G+  Q   +V   + + + +IR L  D+Q
Sbjct: 433  ANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQ 492

Query: 591  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG------------------VAAP 632
             L+D  + Q E++  RV RL + LV +R E     + G                   A P
Sbjct: 493  ILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEP 552

Query: 633  ATQVAQVTLQSVQRRP----EL-------EDSTLRYLQDLLAWVEENQHRVDGAEWGVDL 681
             T+    +  S  R+P    EL       ++  LR++ +LL+WVEE Q +++ AEWG DL
Sbjct: 553  LTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDL 612

Query: 682  PSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS 741
            PSVE QL + + +H S+EE  + ++ AR  EG++S     +Y + LG+L+ QY KL  +S
Sbjct: 613  PSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETS 672

Query: 742  KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 801
              R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD N+N++AK+  +S L  ELE K
Sbjct: 673  SFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEK 732

Query: 802  EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFF 861
            +   + LQ+  + L  E+HPA+ TVE++ AA+Q+Q  WM QLC C+E H+KEN AYFQFF
Sbjct: 733  QDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFF 792

Query: 862  SDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 921
            SD RE E  L+ LQ++++RK SCD + +++RLEDLLQD+ DEKEQL + K  ++ L  R+
Sbjct: 793  SDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRS 852

Query: 922  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 981
            K +VQLKPR P H ++  + + AVCDY+Q+E+T+ K DEC L   +Q + WKV+S +G+E
Sbjct: 853  KTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNE 912

Query: 982  AAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 1041
            A VPSVCFL+PPPN++  E  +R+E  +Q ++ LWHQLHV+ KSL++W  LR+D+ L+++
Sbjct: 913  AMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQT 972

Query: 1042 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL 1101
            W+L   R+  P E  Q + +L+ HY+ FL+DS+D+  F   DRL  E E  +C   +Q L
Sbjct: 973  WNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHL 1032

Query: 1102 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR----LPLDKEPARECAQRIA 1157
            ++S+E   +EE+  +  ISELK+IRL+LE  E R V R++       D++  ++ A RIA
Sbjct: 1033 MKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIA 1092

Query: 1158 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1217
            EQ+  Q +++ L   +  +S + +  L     S + PTLRSEL L + K++ V  LS +Y
Sbjct: 1093 EQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVY 1152

Query: 1218 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1277
            L KLKT+ +++R  Q AE +++ +E +L + + V A L  LEA  ++L+   +  + +  
Sbjct: 1153 LNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNS 1212

Query: 1278 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
             F  L +E+  A+ V E++ +   ER++++ER++E+ +QL ERW  V+AQ ++RQ ELE 
Sbjct: 1213 VFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELES 1272

Query: 1338 LGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
            +   L  YR     L  W+++   +QE ++
Sbjct: 1273 IQEVLGDYRACHGTLIKWIEETTAQQEMMK 1302



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 170/934 (18%), Positives = 373/934 (39%), Gaps = 140/934 (14%)

Query: 446  EIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAG--QLKVPPGYHPLD-VEKE 502
            E+EI+  Q   FK  +    +  + + + +    +G +Q+      V    H ++ +   
Sbjct: 3198 EVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINAR 3257

Query: 503  WGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAG 562
            W  L+  + +R  QL+                 +  G  ++ L    + L     L+A  
Sbjct: 3258 WNTLNKKVAQRIAQLQEAL--------------LHCGKFQDALEPLLSWLADTEELIANQ 3303

Query: 563  KVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------GRHPQGEQMYRRVYRLHERLVA 616
            K P    +V +   +   +++ L +D +   D      GR  Q  ++  R  ++  +L +
Sbjct: 3304 KPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE-KITGQLES 3362

Query: 617  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAE 676
            + + +   L +  AA   Q+  + + + Q     E      + D L+  E+     +   
Sbjct: 3363 LESRWT-ELLSKAAARQKQLEDILVLAKQFHETAEP-----ISDFLSVTEKKLANSEPV- 3415

Query: 677  WGVDLPSVEAQLGSHRGLHQSIEEFQAKIERA----RSDEGQLSPATRGAYRDCLGRLDL 732
             G     ++ Q+  H+ L + IE     + +A    +S     SPA +G   + +  L  
Sbjct: 3416 -GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQA 3474

Query: 733  QYAKLLNSS--KARL--RSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKK 788
            +Y+++ +    KA L  ++L +   F     + L WL E E++       D   ++  ++
Sbjct: 3475 RYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ 3534

Query: 789  ES-YSALMRELELKEKKIKELQNAGDRLLREDHPARPT-VESFQAALQTQWSWMLQLCCC 846
             + + AL  E+  ++K + +    G  LL++        ++     ++T+++ +      
Sbjct: 3535 HADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSK 3594

Query: 847  IEAHLKE-NAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKE 905
                L++      +F S   E  G L++++E L    S  +S T  ++    Q  ++ K+
Sbjct: 3595 ALRTLEQARQLATKFQSTYEELTGWLREVEEELA--TSGGQSPTGEQIPQFQQRQKELKK 3652

Query: 906  QLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVG 965
            ++ E++  L  + + ++A+++L P       R R  L                   +LV 
Sbjct: 3653 EVMEHRLVLDTVNEVSRALLELVP------WRAREGL------------------DKLVS 3688

Query: 966  PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKS 1025
             A   +  V  + G                 E+  A+ R +   QA       +    + 
Sbjct: 3689 DANEQYKLVSDTIGQRV-------------DEIDAAIQRSQQYEQAADAELAWVAETKRK 3735

Query: 1026 LLAWQSLRRD-------VQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 1078
            L+A   +R +       +Q+ +++S+   R       + ++  L      F   S+  G 
Sbjct: 3736 LMALGPIRLEQDQTTAQLQVQKAFSIDIIR------HKDSMDEL------FSHRSEIFGT 3783

Query: 1079 FGPEDRLMAEREYGSCSHHYQQL-LQSLEQGAQEESRCQRCISELKDIRLQLEAC--ETR 1135
             G E + + + +  S    Y+ + L + E+ A+ E R Q  +++  +   +L     ETR
Sbjct: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLE-RAQVLVNQFWETYEELSPWIEETR 3842

Query: 1136 T-VHRLRLP-LDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPA 1192
              + +L  P +D E  R+           Q E+  L + +A      +K+L + P+    
Sbjct: 3843 ALIAQLPSPAIDHEQLRQ----------QQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 3892

Query: 1193 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI-----RGTQGAE---------EVL 1238
             P    E E+   K ++  ++ A   E+++  +L +     + TQ  E         E L
Sbjct: 3893 NP---EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETL 3949

Query: 1239 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1298
                 +L+    +PA + ++    +  K    + E  QP+F+AL+   RG + +G   + 
Sbjct: 3950 ENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALK--RRGEELIG---RS 4004

Query: 1299 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1332
            +  ++D+  +  ++++ Q++  W+ + A+ + R+
Sbjct: 4005 QGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038



 Score = 51.2 bits (121), Expect = 7e-06
 Identities = 231/1127 (20%), Positives = 429/1127 (38%), Gaps = 164/1127 (14%)

Query: 339  DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 398
            D N V+   + E + +A  VAE+   ++RL    ++D+ +  EK      S L +   RV
Sbjct: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259

Query: 399  PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 455
               Q  +R +EL+   +   +YR     L++W+   TA  +E   P   E+  +L  Q  
Sbjct: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317

Query: 456  KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 496
            +   +  E+   +   ++ +   Q     V+  +L++             PG        
Sbjct: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377

Query: 497  --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQA 548
                    +D+   +  L     +  K +     RLE  +++V + +      +E + + 
Sbjct: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEK------QEHVEKV 1431

Query: 549  DALLQ--SDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------ 594
              LL   S +     GK      +   D++KA    ++L  ++ T K+            
Sbjct: 1432 KELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIF 1491

Query: 595  -GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELE 651
              +H  G ++  +  + + E+L A+   Y+  L  G A    Q+ +Q+  Q+ Q+  + +
Sbjct: 1492 LAKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQ 1548

Query: 652  DSTL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFQAKIER 707
             +T  + L+DL +WV + +  + G +      DL +++      + L   I+        
Sbjct: 1549 QNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFAT 1608

Query: 708  ARSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV---- 755
               D        + +LSP    A R+ L +   QY  L   ++   + LE   +      
Sbjct: 1609 VVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQE 1668

Query: 756  ---AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-I 805
               + A KEL    +K +        VG       TN+   ++   A + +  L      
Sbjct: 1669 TEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGY 1728

Query: 806  KELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVR 865
              +  A ++L   D          Q  L  Q +++L       A     A   Q   ++ 
Sbjct: 1729 MGVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLT 1778

Query: 866  EAEGQL--QKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAK 922
              E Q+  QKL E L+ + S   + +   L+ + Q  QDE ++ L ++K   S L +  K
Sbjct: 1779 PEEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK 1836

Query: 923  AVVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS- 980
               +L+  H        LP LL        +V  HKGD   +    Q    KVL    S 
Sbjct: 1837 ---ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSF 1889

Query: 981  -EAAVPS-VCFLVPPPNQEVQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-Q 1030
             E   PS +  LV    ++  E  T       RL +    L+  +HQ      SL AW Q
Sbjct: 1890 KEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQ 1949

Query: 1031 SLRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGP 1081
            +   +V+ + S ++A+          T K  ++  A H + +   Q   RD  +  G   
Sbjct: 1950 ACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPA 2009

Query: 1082 EDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR 1141
             D    +    S   H+Q L  SL   A+  S  Q+ I++ + ++  LE+   +++  + 
Sbjct: 2010 PDHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVE 2065

Query: 1142 LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPE--PSPAAPT 1195
              L+ +     +  +   Q+A A    L + +AR    L A  E V    E   S  A  
Sbjct: 2066 QNLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2123

Query: 1196 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEE--QLKEAQAVPA 1253
            L+ +L     + EQ   L     EK  ++  ++   +  E +    ++  + K       
Sbjct: 2124 LQGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG 2180

Query: 1254 TLPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1311
              P+ + T     +++L  + E QQ   D L   +      G  L         ++ + +
Sbjct: 2181 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQ 2231

Query: 1312 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1358
            +RV  L + +  +      R+++      QL  +R+       WL++
Sbjct: 2232 DRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKE 2278



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 80/379 (21%), Positives = 144/379 (37%), Gaps = 58/379 (15%)

Query: 996  QEVQEAVTRLEAQHQALVTLWHQLHVDMKSL---LAWQSLRRDVQLIRSWSLATFRTLKP 1052
            Q++QE    +E Q + L TL H L  ++ S    L     +  VQ +R       +T+K 
Sbjct: 2192 QQIQELNLEMEDQQENLDTLEH-LVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE 2250

Query: 1053 --------EEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQS 1104
                    +EQ      L   +Q +L++++  G   P +  M+ +E      H + LL  
Sbjct: 2251 REKDASSCQEQLDEFRKLVRTFQKWLKETE--GSIPPTETSMSAKELEKQIEHLKSLLDD 2308

Query: 1105 LEQGAQ--EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKA 1162
                    EE  C+   + L+++ +++ A +++      LP                  +
Sbjct: 2309 WASKGTLVEEINCKG--TSLENLIMEITAPDSQGKTGSILP--------------SVGSS 2352

Query: 1163 QAEVEGLG--KGVARLSAEAEKVLALPEPSPAAPTLRSE-LELTLGKLEQVRSLSAIYLE 1219
               V G    K +  +  +   V    E        R E L+  L ++E+V         
Sbjct: 2353 VGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVH-------- 2404

Query: 1220 KLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1279
              K  + V++  +  EEVL++      +A + P     ++A   S K   A+ E   P  
Sbjct: 2405 --KEANSVLQWLESKEEVLKS-----MDAMSSPTKTETVKAQAESNKAFLAELEQNSPKI 2457

Query: 1280 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG 1339
              +++ L G        Q        E E W++   +L  RW+     T  RQR+LE+  
Sbjct: 2458 QKVKEALAGLLVTYPNSQ--------EAENWKKIQEELNSRWERATEVTVARQRQLEESA 2509

Query: 1340 RQLRYYRESADPLGAWLQD 1358
              L  ++ +   L  WL +
Sbjct: 2510 SHLACFQAAESQLRPWLME 2528



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 43/238 (18%), Positives = 95/238 (39%), Gaps = 21/238 (8%)

Query: 1147 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1206
            E  R   QR++ Q     + E + + +   S     +  L      A TL  EL + +G+
Sbjct: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694

Query: 1207 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1265
                + L     ++L+T++L ++G +  A + +   +  L   Q       EL       
Sbjct: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750

Query: 1266 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1309
            +  +A+        + L+ +L+  +E  + L Q  G  +V                E   
Sbjct: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810

Query: 1310 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
             + ++ +L   W+ +  +T  RQ  L+   ++ + Y+   + L  W++D + +  +++
Sbjct: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELR 2868



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 68/321 (21%), Positives = 127/321 (39%), Gaps = 25/321 (7%)

Query: 1053 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 1109
            EE RQ   S+   + H    L+         PE+  M E +Y    + Y Q+ + + Q A
Sbjct: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922

Query: 1110 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1161
                E       I+E  D I   LE  E  +  RLR    +P + +  REC   I++ + 
Sbjct: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978

Query: 1162 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1217
            A  E+E L      L    E+++   + +    AA  ++ +L+  +   E +++      
Sbjct: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038

Query: 1218 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1277
            ++ L  + L  +       +L      +K+ Q +   L       + +K+    AE  + 
Sbjct: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094

Query: 1278 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
              D L +EL   + +G  L    GE   E    R+ + ++   W+ +      R  +LE 
Sbjct: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152

Query: 1338 LGRQLRYYRESADPLGAWLQD 1358
              +    Y+++   +  WL +
Sbjct: 4153 AMQAAVQYQDTLQAMFDWLDN 4173



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 55/226 (24%), Positives = 104/226 (46%), Gaps = 25/226 (11%)

Query: 1099 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1158
            + LL S+  G +E+   Q  + ELK+     E    +T  R      +   ++C Q+   
Sbjct: 2796 ESLLLSVPPG-EEKRTLQNQLVELKN---HWEELSKKTADR------QSRLKDCMQKA-- 2843

Query: 1159 QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL 1218
             QK Q  VE L   +    A+  ++    +P     +L     + L ++E+ RSL    L
Sbjct: 2844 -QKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAM-LNEVEKRRSL----L 2897

Query: 1219 EKLKTIS-LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1277
            E L + + ++I  ++  E+ +R  +E+    Q + A   EL+A   SL+++  +    Q 
Sbjct: 2898 EILNSAADILINSSEADEDGIR--DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQE 2955

Query: 1278 TFDALRDELRGAQ---EVGERL-QQRHGERDVEVERWRERVAQLLE 1319
            +F  +  ++ GA+   E+ + L  Q    +++E  R ++ V Q LE
Sbjct: 2956 SFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALE 3001



 Score = 35.4 bits (80), Expect = 0.38
 Identities = 189/1052 (17%), Positives = 384/1052 (36%), Gaps = 169/1052 (16%)

Query: 382  KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 441
            K + T+   L +    +P  +  + A EL+   ++   L  LL  W    T   E     
Sbjct: 2267 KLVRTFQKWLKETEGSIPPTETSMSAKELE---KQIEHLKSLLDDWASKGTLVEEINCKG 2323

Query: 442  SSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPL---- 497
            +S E +            ME+ A ++ + ++  I  S+  +V +       GYH      
Sbjct: 2324 TSLENLI-----------MEITAPDS-QGKTGSILPSVGSSVGSVN-----GYHTCKDLT 2366

Query: 498  -------DVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADA 550
                   DV  ++ KL   + ER++ L++   R+E + +    +       EE L   DA
Sbjct: 2367 EIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDA 2426

Query: 551  LLQ-SDIRLLAAGKVPQRA--GEVERDLDKADSMIRLLFNDVQTLKDGRHPQG-EQMYRR 606
            +   +    + A     +A   E+E++  K   +   L   + T  + +  +  +++   
Sbjct: 2427 MSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEE 2486

Query: 607  VYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVE 666
            +    ER     TE  +  +  +   A+ +A       Q RP L +  L  +  +L  + 
Sbjct: 2487 LNSRWERA----TEVTVARQRQLEESASHLACFQAAESQLRPWLMEKEL--MMGVLGPLS 2540

Query: 667  ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDC 726
             + + ++  +       V+  L       Q  E+     +   +  G +S +T    ++ 
Sbjct: 2541 IDPNMLNAQK-----QQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKE- 2594

Query: 727  LGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEK-----EEEEVGFDWSDRN 781
            L  ++ ++ +L +   +R   ++          + L  L+EK     +   V    S + 
Sbjct: 2595 LQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQP 2654

Query: 782  TNMTAKKESYSALMRELELKEKKIKELQNA--------GDRLLREDHPARPTVESFQAAL 833
              +  + E  S +  +LE  + ++KE Q          G++ L+++   R  +E+    L
Sbjct: 2655 EAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR--LETVALPL 2712

Query: 834  QTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRL 893
            Q            ++A L     + Q F ++R      Q  Q       +C  SA + RL
Sbjct: 2713 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQA-----KNCPISAKLERL 2767

Query: 894  EDLLQDAQDEKEQLNEYKGHLSGL-AKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVE 952
            +  LQ+ ++ ++ LN++ G    + A+    ++ + P      ++ +L  L         
Sbjct: 2768 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL--------- 2818

Query: 953  VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRL-EAQHQA 1011
                             +HW+ LS                   ++  +  +RL +   +A
Sbjct: 2819 ----------------KNHWEELS-------------------KKTADRQSRLKDCMQKA 2843

Query: 1012 LVTLWHQLHV-----DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHY 1066
                WH   +     D K+ ++   +  D   + S  L +   L   E+R++L  +    
Sbjct: 2844 QKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSA 2903

Query: 1067 QAFLRDSQDAGGFGPED-RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1125
               L +S +A   G  D +    +   + +   Q    SLE+  Q   R +      K+I
Sbjct: 2904 ADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQ---RLREFQESFKNI 2960

Query: 1126 RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEV---------------EGL- 1169
              ++E  +    H+L +  D   ++ C+ +  E+ +AQ EV               +GL 
Sbjct: 2961 EKKVEGAK----HQLEI-FDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLV 3015

Query: 1170 -----GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1224
                 G   ++L  +AE  +A  E       + S   +   KLE +        E    +
Sbjct: 3016 EDAPDGSDASQLLHQAE--VAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQL 3073

Query: 1225 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE---AQQPTFD- 1280
            + +     G   + R  +    + + V   L ++   K  ++   A+      ++ T D 
Sbjct: 3074 ADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDL 3133

Query: 1281 -ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------ 1333
              L+ EL    +   +L +R   R  ++E    RV     + + +   T   +       
Sbjct: 3134 LGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQW 3193

Query: 1334 ----ELEQLGRQL----RYYRESADPLGAWLQ 1357
                E+E + +QL     + +E  DPL   LQ
Sbjct: 3194 VVGTEVEIINQQLADFKMFQKEQVDPLQMKLQ 3225



 Score = 35.0 bits (79), Expect = 0.49
 Identities = 47/212 (22%), Positives = 92/212 (43%), Gaps = 32/212 (15%)

Query: 1159 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1214
            Q K Q +V GLG+G+ + + +   V  L     E +    TL  ++   + +L++     
Sbjct: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279

Query: 1215 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1274
              + + L+ +   +  T   EE++   +    E + V A + E        K L+   + 
Sbjct: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329

Query: 1275 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1330
            ++ T D L+ E       G R+ Q     D      RE++   LE    RW  +L++   
Sbjct: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376

Query: 1331 RQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362
            RQ++LE +    + + E+A+P+  +L    ++
Sbjct: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKK 3408



 Score = 34.7 bits (78), Expect = 0.64
 Identities = 58/271 (21%), Positives = 108/271 (39%), Gaps = 35/271 (12%)

Query: 1099 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1158
            QQL  +L+Q     S  +  + EL  +  QL A +        LP       +    +  
Sbjct: 4367 QQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTG----GLPETAREQLDTHMELYS 4422

Query: 1159 QQKAQAEVEG--LGKGVARL--------SAEAEKVLALPEPSPAAPTLRSELELTLGKLE 1208
            Q KA+ E     L KG   L         ++ E+ +AL E       + S++E    KLE
Sbjct: 4423 QLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQK--WHVVSSKMEERKSKLE 4480

Query: 1209 QVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL 1268
            +  +L+  +   L+     I     AE+ L         +  +   L ++E  K    ++
Sbjct: 4481 EALNLATEFQNSLQEF---INWLTLAEQSLNIASPP---SLILNTVLSQIEEHKVFANEV 4534

Query: 1269 RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1328
             A            RD++    + G +L+    ++DV + +    +  +  RW+ V+ ++
Sbjct: 4535 NAH-----------RDQIIELDQTGNQLKFLSQKQDVVLIK--NLLVSVQSRWEKVVQRS 4581

Query: 1329 DVRQRELEQLGRQLRYYRESADPLGAWLQDA 1359
              R R L+   ++ + + E+   L  WL+DA
Sbjct: 4582 IERGRSLDDARKRAKQFHEAWKKLIDWLEDA 4612



 Score = 34.7 bits (78), Expect = 0.64
 Identities = 48/246 (19%), Positives = 97/246 (39%), Gaps = 23/246 (9%)

Query: 638  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 690
            +V  +S++R   L+D+  R  Q       L+ W+E+ +  +D   E   D   ++ QL  
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635

Query: 691  HRGLHQSI----EEFQAKIERARS-DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARL 745
            H+   +++      +   I   R+  E  L P       + LG +  ++  +   S  R 
Sbjct: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ 4695

Query: 746  RSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 797
              LE        F+ A    + WL + E    E++      D   N+    +++    +E
Sbjct: 4696 HKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQKE 4752

Query: 798  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 857
            L  +   ++ L+ +G  L+         V+     L T+W  + +L    ++ L++    
Sbjct: 4753 LGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQ 4812

Query: 858  FQFFSD 863
             + F D
Sbjct: 4813 AEVFRD 4818



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 136/711 (19%), Positives = 254/711 (35%), Gaps = 90/711 (12%)

Query: 678  GVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSD-EGQLSPAT----RGAYRDCLGRLDL 732
            G DL +V+ QL   +     + + Q ++E+     E  L  AT    R   R+ L  L  
Sbjct: 4185 GTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKH 4244

Query: 733  QYAKLLNSSKARLRSLE----SLHSFVAAATKELMWLNEKEEE-EVGFDWSDRNTNMTAK 787
             +  L      R   LE    +L  F  A  + + WL   EE  +     S     +  +
Sbjct: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304

Query: 788  KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ---WSWMLQLC 844
               +  L  ++   +  ++ +  AG+ LL     A     S ++ L+     W  +LQ  
Sbjct: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESS--AGDDASSLRSRLEAMNQCWESVLQ-- 4360

Query: 845  CCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEK 904
                   K      Q  S +++A+G   ++++ L      +   + ++    L +    +
Sbjct: 4361 -------KTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETA--R 4411

Query: 905  EQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLV 964
            EQL+ +    S L  + +   QL  +       GRL LL+  D          G + +  
Sbjct: 4412 EQLDTHMELYSQLKAKEETYNQLLDK-------GRLMLLSRDDSGS-------GSKTEQS 4457

Query: 965  GPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMK 1024
                   W V+SS                   +++E  ++LE      + L  +    ++
Sbjct: 4458 VALLEQKWHVVSS-------------------KMEERKSKLEEA----LNLATEFQNSLQ 4494

Query: 1025 SLLAWQSLRRDVQLIRSWSLATFRTL--KPEEQRQALHSLELHYQAFLRDSQDAGGFG-- 1080
              + W +L      I S       T+  + EE +   + +  H    +   Q        
Sbjct: 4495 EFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFL 4554

Query: 1081 --PEDRLMAEREYGSCSHHYQQLLQ-SLEQGAQEES---RCQRCISELKDIRLQLEACET 1134
               +D ++ +    S    +++++Q S+E+G   +    R ++     K +   LE  E+
Sbjct: 4555 SQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAES 4614

Query: 1135 RTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1194
                 L +  D +  +    +  E QK     + +     R     ++   LPE S    
Sbjct: 4615 HLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLD 4674

Query: 1195 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLV----IRGTQGAEEVLRAHEEQLKEAQA 1250
                E+     K + V   S     KL+   L     +   Q   + L   E QL E Q 
Sbjct: 4675 NFLGEVR---DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQP 4731

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            V   L  +     + K  + +   +  T   L+   R  +E+ E        RD +    
Sbjct: 4732 VHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLK---RSGRELIEN------SRD-DTTWV 4781

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1361
            + ++ +L  RW  V   +  +Q  LEQ  +Q   +R++   L  WL +A +
Sbjct: 4782 KGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 4832



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 170/920 (18%), Positives = 353/920 (38%), Gaps = 169/920 (18%)

Query: 498  DVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIR 557
            D E+   K++++ L   K +R   E  E  QR+V ++Q  A    ++    DA   + +R
Sbjct: 1040 DKEETVAKMYISEL---KNIRLRLEEYE--QRVVKRIQSLASSRTDR----DAWQDNALR 1090

Query: 558  LLAAGKVPQRAGEVERDLD----KADSMIRLL--FNDVQTLKDGRHPQGEQMYRRVYRLH 611
            +       +   ++  DLD    K DS +      + V TL+   +   E+M        
Sbjct: 1091 IAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKM-------- 1142

Query: 612  ERLVAIRTEYNLRLKA-GVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQH 670
            + +  + T Y  +LK   V   + Q A++ ++  + +   E+  L  L  L A     +H
Sbjct: 1143 DHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRH 1202

Query: 671  RVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRL 730
             +   +   D  SV + L       + + E  +++   R+ + +        Y++   +L
Sbjct: 1203 WLSDVK---DKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLE-------RYQEKGSQL 1252

Query: 731  DLQYAKLLNSSKARLRSLESLHSFV----AAATKELMWLNEK--EEEEVGFDWSDRNTNM 784
              ++ +++   + R   LES+   +    A     + W+ E   ++E +    ++ +  +
Sbjct: 1253 QERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVL 1312

Query: 785  TAKKESYSALMRELELKEKKIKELQNAGDR---LLREDHPARPTVESFQAALQTQWSWML 841
            + +    +AL  E+E  + K+ + Q    +   ++++      T ++F  + Q       
Sbjct: 1313 SEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRR 1372

Query: 842  QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKL--------QEALRRKNSCDRSATVTRL 893
            ++       L  + A  Q F D+R     L  L         +ALRR    ++       
Sbjct: 1373 RM-------LSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVE---- 1421

Query: 894  EDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEV 953
                ++ Q+  E++ E  G +S LA+  +               G+       +   +E 
Sbjct: 1422 ----EEKQEHVEKVKELLGWVSTLARNTQ---------------GKATSSETKESTDIEK 1462

Query: 954  TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALV 1013
             +       L                SEA   S  FL    ++  ++   ++  Q  AL 
Sbjct: 1463 AI-------LEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALN 1515

Query: 1014 TLWHQLH-------VDMKSLLAWQSLRRDVQL-----------IRSWSLATFRTLKPEEQ 1055
              +H L          ++S LA Q+ ++ +Q            + SW     R L   + 
Sbjct: 1516 KAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQG 1575

Query: 1056 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 1112
            R   Q L +L+ + Q+ L+D QD              +  + +  +  +++ +E G  EE
Sbjct: 1576 RTTQQDLSALQKN-QSDLKDLQD--------------DIQNRATSFATVVKDIE-GFMEE 1619

Query: 1113 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGL--- 1169
            ++ +    EL  +R +L   +           ++  A +   R+A+++  +A    L   
Sbjct: 1620 NQTKLSPRELTALREKLHQAK-----------EQYEALQEETRVAQKELEEAVTSALQQE 1668

Query: 1170 ---GKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISL 1226
                K    L+   +K+ AL +   +  +   +L   L  +EQ   LS   LEK      
Sbjct: 1669 TEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQ---LSGASLEKG----- 1720

Query: 1227 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1286
             +  T G   V +A E+  K+ + + A   EL + + +   + A   AQ     A  D  
Sbjct: 1721 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNF--ILATQSAQ-----AFLD-- 1771

Query: 1287 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1346
                      Q  H     E +  ++++ +L E++   LAQ++   ++++ L  +L+ + 
Sbjct: 1772 ----------QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFL 1821

Query: 1347 ESADPLGAWLQDARRRQEQI 1366
            +      +WL+ + +  E +
Sbjct: 1822 QDHKEFESWLERSEKELENM 1841


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  667 bits (1721), Expect = 0.0
 Identities = 314/717 (43%), Positives = 503/717 (70%)

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ 
Sbjct: 630  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 689

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 690  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 749

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 750  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 809

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RK SCDRS+++
Sbjct: 810  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 869

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 870  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 929

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+E  +   R+E Q+Q
Sbjct: 930  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 989

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 990  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1049

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1050 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1109

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1110 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1169

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1170 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1229

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1230 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1289

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ
Sbjct: 1290 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1346



 Score =  560 bits (1444), Expect = e-159
 Identities = 269/450 (59%), Positives = 360/450 (80%), Gaps = 1/450 (0%)

Query: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
           DERD+VQKKT TKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 60  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 119

Query: 231 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
           H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 120 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 179

Query: 291 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
           M+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V  Q+NL 
Sbjct: 180 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 239

Query: 351 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
           NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP+  +G+ AN++
Sbjct: 240 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 298

Query: 411 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
           +++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE E+P KE +K+
Sbjct: 299 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 358

Query: 471 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
           + K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 359 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 418

Query: 531 VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
             ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++R    DVQ
Sbjct: 419 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 478

Query: 591 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620
            L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 479 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 508



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 154/796 (19%), Positives = 310/796 (38%), Gaps = 129/796 (16%)

Query: 645  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 697
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 3325 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3384

Query: 698  IEEFQAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 3385 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3443

Query: 754  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 807
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 3444 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3503

Query: 808  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 846
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 3504 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3561

Query: 847  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKNSCDRSATVTRLED 895
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 3562 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3620

Query: 896  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 943
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 3621 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3680

Query: 944  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 997
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 3681 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3739

Query: 998  VQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1052
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 3740 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3799

Query: 1053 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1096
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 3800 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3859

Query: 1097 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1145
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 3860 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3919

Query: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1205
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 3920 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3977

Query: 1206 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1261
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 3978 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4027

Query: 1262 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1319
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 4028 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4080

Query: 1320 RWQAVLAQTDVRQREL 1335
             W+ +    + R+ +L
Sbjct: 4081 IWENIHTLVEEREAKL 4096



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 60/296 (20%), Positives = 122/296 (41%), Gaps = 35/296 (11%)

Query: 1083 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1136
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3247

Query: 1137 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1188
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 3248 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3298

Query: 1189 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1248
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 3299 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3357

Query: 1249 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1308
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 3358 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3410

Query: 1309 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R
Sbjct: 3411 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKR 3466



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 56/223 (25%), Positives = 95/223 (42%), Gaps = 26/223 (11%)

Query: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1202
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 4247 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4299

Query: 1203 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1258
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 4300 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4356

Query: 1259 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1318
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4407

Query: 1319 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1361
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R
Sbjct: 4408 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4450



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 1213 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1272
            L  +  +K+  ++  +   Q A+E   A  + L++     AT  +        + ++ Q 
Sbjct: 2440 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-ATKWQQTPAPTDTEAVKTQV 2498

Query: 1273 EAQQPTFDA-LRDELRGAQEVGERLQQRHGERD--VEVERWRERVAQLLERWQAVLAQTD 1329
            E Q  +F+A L+  +   QE+ ++L +   E     E  RW++ + ++  +WQ +   T 
Sbjct: 2499 E-QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2557

Query: 1330 VRQRELEQLGRQLRYYRESADPLGAWL 1356
             RQ++LE+    L  ++     L  WL
Sbjct: 2558 DRQQKLEESSNNLTQFQTVEAQLKQWL 2584



 Score = 35.4 bits (80), Expect = 0.38
 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)

Query: 497  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDI 556
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 4622 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4674

Query: 557  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 616
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 4675 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4720

Query: 617  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 668
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 4721 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4778

Query: 669  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLG 728
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 4779 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4833

Query: 729  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 774
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+  + 
Sbjct: 4834 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4889

Query: 775  FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 821
            F     D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 4890 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4938



 Score = 34.7 bits (78), Expect = 0.64
 Identities = 77/390 (19%), Positives = 150/390 (38%), Gaps = 56/390 (14%)

Query: 996  QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1055
            Q V+  + +   + + +V++   L +D   L    + R+ VQ++    L  F T KP+ +
Sbjct: 2574 QTVEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQIL----LQEFATRKPQYE 2626

Query: 1056 RQALHSLELHYQAFL-RDSQDAG--GFGPEDRLMAEREY----GSCSHHYQQLLQSLEQG 1108
            +     L    Q  L R  +D    G   E      +++    G  S     + Q++ + 
Sbjct: 2627 Q-----LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2681

Query: 1109 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1168
             Q +S  +    +L D+  +L +    + H   +    E A++  Q I +Q+K Q +V  
Sbjct: 2682 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI-QQEKKQIKVA- 2739

Query: 1169 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1228
                     A  E + AL +       L  +LE  L   + V   +  +++ L++     
Sbjct: 2740 --------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2791

Query: 1229 RGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KASLKKLRAQAEAQQPTF- 1279
               Q      +A  +  KE Q     + A L  LE+     K   K L AQ+   + T  
Sbjct: 2792 HQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIA 2851

Query: 1280 --DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
              + L  + +G+++   +LQ                +  +   W     Q   R+ +L++
Sbjct: 2852 EGENLLLKTQGSEKAALQLQ----------------LNTIKTNWDTFNKQVKERENKLKE 2895

Query: 1338 LGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
               +   Y+E  + L  W+   +   E+I+
Sbjct: 2896 SLEKALKYKEQVETLWPWIDKCQNNLEEIK 2925



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)

Query: 638  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 690
            +V  + V+R   L+D+  R  Q       L+ W+EE++  +D   E   D   ++ QL  
Sbjct: 4630 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4689

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 745
            H+   +S+    +  +        L   T  A       D L  L  ++  +   S  R 
Sbjct: 4690 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4749

Query: 746  RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 797
              LE    F    T  L     WL   E    E++      D   N+    +++ A  +E
Sbjct: 4750 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4806

Query: 798  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 857
            L  +   ++ L+ +   L+         V+     L T+W  +  L    +  L+     
Sbjct: 4807 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4866

Query: 858  FQFFSDVREA 867
             + F  V  A
Sbjct: 4867 AEEFHSVVHA 4876



 Score = 32.3 bits (72), Expect = 3.2
 Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 29/142 (20%)

Query: 415  QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 474
            QE  E +L  LQW        ++   P   EE++ L ++   F E E+  K+ D ++   
Sbjct: 4980 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFME-EMTRKQPDVDKVTK 5038

Query: 475  IYQ-------SLEGAV------QAGQLKVP-----PGYHPLDVE----------KEWGKL 506
             Y+       SL+  +      +AG+ + P     P      +E           +W ++
Sbjct: 5039 TYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQV 5098

Query: 507  HVAILEREKQLRSEFERLECLQ 528
             +  LER ++L    +RLE L+
Sbjct: 5099 WLLALERRRKLNDALDRLEELR 5120


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  667 bits (1721), Expect = 0.0
 Identities = 314/717 (43%), Positives = 503/717 (70%)

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ 
Sbjct: 641  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 701  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 761  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RK SCDRS+++
Sbjct: 821  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 881  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+E  +   R+E Q+Q
Sbjct: 941  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ
Sbjct: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1357



 Score =  560 bits (1444), Expect = e-159
 Identities = 269/450 (59%), Positives = 360/450 (80%), Gaps = 1/450 (0%)

Query: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
           DERD+VQKKT TKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 71  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 130

Query: 231 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
           H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 131 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 190

Query: 291 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
           M+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V  Q+NL 
Sbjct: 191 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 250

Query: 351 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
           NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP+  +G+ AN++
Sbjct: 251 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 309

Query: 411 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
           +++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE E+P KE +K+
Sbjct: 310 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 369

Query: 471 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
           + K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 370 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 429

Query: 531 VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
             ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++R    DVQ
Sbjct: 430 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 489

Query: 591 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620
            L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 490 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 519



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 154/796 (19%), Positives = 310/796 (38%), Gaps = 129/796 (16%)

Query: 645  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 697
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395

Query: 698  IEEFQAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454

Query: 754  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 807
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514

Query: 808  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 846
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572

Query: 847  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKNSCDRSATVTRLED 895
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631

Query: 896  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 943
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691

Query: 944  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 997
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750

Query: 998  VQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1052
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810

Query: 1053 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1096
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870

Query: 1097 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1145
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930

Query: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1205
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988

Query: 1206 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1261
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038

Query: 1262 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1319
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091

Query: 1320 RWQAVLAQTDVRQREL 1335
             W+ +    + R+ +L
Sbjct: 4092 IWENIHTLVEEREAKL 4107



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 60/296 (20%), Positives = 122/296 (41%), Gaps = 35/296 (11%)

Query: 1083 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1136
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258

Query: 1137 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1188
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309

Query: 1189 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1248
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368

Query: 1249 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1308
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421

Query: 1309 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R
Sbjct: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKR 3477



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 56/223 (25%), Positives = 95/223 (42%), Gaps = 26/223 (11%)

Query: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1202
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310

Query: 1203 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1258
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367

Query: 1259 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1318
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418

Query: 1319 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1361
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R
Sbjct: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4461



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 1213 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1272
            L  +  +K+  ++  +   Q A+E   A  + L++     AT  +        + ++ Q 
Sbjct: 2451 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-ATKWQQTPAPTDTEAVKTQV 2509

Query: 1273 EAQQPTFDA-LRDELRGAQEVGERLQQRHGERD--VEVERWRERVAQLLERWQAVLAQTD 1329
            E Q  +F+A L+  +   QE+ ++L +   E     E  RW++ + ++  +WQ +   T 
Sbjct: 2510 E-QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2568

Query: 1330 VRQRELEQLGRQLRYYRESADPLGAWL 1356
             RQ++LE+    L  ++     L  WL
Sbjct: 2569 DRQQKLEESSNNLTQFQTVEAQLKQWL 2595



 Score = 35.4 bits (80), Expect = 0.38
 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)

Query: 497  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDI 556
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685

Query: 557  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 616
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731

Query: 617  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 668
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789

Query: 669  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLG 728
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844

Query: 729  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 774
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+  + 
Sbjct: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4900

Query: 775  FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 821
            F     D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 4901 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949



 Score = 34.7 bits (78), Expect = 0.64
 Identities = 77/390 (19%), Positives = 150/390 (38%), Gaps = 56/390 (14%)

Query: 996  QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1055
            Q V+  + +   + + +V++   L +D   L    + R+ VQ++    L  F T KP+ +
Sbjct: 2585 QTVEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQIL----LQEFATRKPQYE 2637

Query: 1056 RQALHSLELHYQAFL-RDSQDAG--GFGPEDRLMAEREY----GSCSHHYQQLLQSLEQG 1108
            +     L    Q  L R  +D    G   E      +++    G  S     + Q++ + 
Sbjct: 2638 Q-----LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2692

Query: 1109 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1168
             Q +S  +    +L D+  +L +    + H   +    E A++  Q I +Q+K Q +V  
Sbjct: 2693 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI-QQEKKQIKVA- 2750

Query: 1169 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1228
                     A  E + AL +       L  +LE  L   + V   +  +++ L++     
Sbjct: 2751 --------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2802

Query: 1229 RGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KASLKKLRAQAEAQQPTF- 1279
               Q      +A  +  KE Q     + A L  LE+     K   K L AQ+   + T  
Sbjct: 2803 HQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIA 2862

Query: 1280 --DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
              + L  + +G+++   +LQ                +  +   W     Q   R+ +L++
Sbjct: 2863 EGENLLLKTQGSEKAALQLQ----------------LNTIKTNWDTFNKQVKERENKLKE 2906

Query: 1338 LGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
               +   Y+E  + L  W+   +   E+I+
Sbjct: 2907 SLEKALKYKEQVETLWPWIDKCQNNLEEIK 2936



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)

Query: 638  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 690
            +V  + V+R   L+D+  R  Q       L+ W+EE++  +D   E   D   ++ QL  
Sbjct: 4641 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4700

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 745
            H+   +S+    +  +        L   T  A       D L  L  ++  +   S  R 
Sbjct: 4701 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4760

Query: 746  RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 797
              LE    F    T  L     WL   E    E++      D   N+    +++ A  +E
Sbjct: 4761 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4817

Query: 798  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 857
            L  +   ++ L+ +   L+         V+     L T+W  +  L    +  L+     
Sbjct: 4818 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877

Query: 858  FQFFSDVREA 867
             + F  V  A
Sbjct: 4878 AEEFHSVVHA 4887



 Score = 32.3 bits (72), Expect = 3.2
 Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 29/142 (20%)

Query: 415  QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 474
            QE  E +L  LQW        ++   P   EE++ L ++   F E E+  K+ D ++   
Sbjct: 4991 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFME-EMTRKQPDVDKVTK 5049

Query: 475  IYQ-------SLEGAV------QAGQLKVP-----PGYHPLDVE----------KEWGKL 506
             Y+       SL+  +      +AG+ + P     P      +E           +W ++
Sbjct: 5050 TYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQV 5109

Query: 507  HVAILEREKQLRSEFERLECLQ 528
             +  LER ++L    +RLE L+
Sbjct: 5110 WLLALERRRKLNDALDRLEELR 5131


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  667 bits (1721), Expect = 0.0
 Identities = 314/717 (43%), Positives = 503/717 (70%)

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ 
Sbjct: 779  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 838

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 839  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 898

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 899  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 958

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RK SCDRS+++
Sbjct: 959  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 1018

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 1019 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 1078

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+E  +   R+E Q+Q
Sbjct: 1079 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1138

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 1139 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1198

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1199 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1258

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1259 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1318

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1319 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1378

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1379 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1438

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ
Sbjct: 1439 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1495



 Score =  560 bits (1444), Expect = e-159
 Identities = 269/450 (59%), Positives = 360/450 (80%), Gaps = 1/450 (0%)

Query: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
           DERD+VQKKT TKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 209 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 268

Query: 231 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
           H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 269 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 328

Query: 291 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
           M+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V  Q+NL 
Sbjct: 329 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 388

Query: 351 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
           NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP+  +G+ AN++
Sbjct: 389 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 447

Query: 411 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
           +++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE E+P KE +K+
Sbjct: 448 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 507

Query: 471 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
           + K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 508 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 567

Query: 531 VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
             ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++R    DVQ
Sbjct: 568 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 627

Query: 591 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620
            L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 628 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 657



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 154/796 (19%), Positives = 310/796 (38%), Gaps = 129/796 (16%)

Query: 645  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 697
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 3474 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3533

Query: 698  IEEFQAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 3534 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3592

Query: 754  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 807
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 3593 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3652

Query: 808  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 846
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 3653 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3710

Query: 847  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKNSCDRSATVTRLED 895
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 3711 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3769

Query: 896  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 943
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 3770 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3829

Query: 944  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 997
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 3830 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3888

Query: 998  VQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1052
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 3889 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3948

Query: 1053 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1096
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 3949 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 4008

Query: 1097 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1145
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 4009 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 4068

Query: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1205
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 4069 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 4126

Query: 1206 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1261
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 4127 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4176

Query: 1262 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1319
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 4177 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4229

Query: 1320 RWQAVLAQTDVRQREL 1335
             W+ +    + R+ +L
Sbjct: 4230 IWENIHTLVEEREAKL 4245



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 60/296 (20%), Positives = 122/296 (41%), Gaps = 35/296 (11%)

Query: 1083 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1136
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3396

Query: 1137 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1188
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 3397 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3447

Query: 1189 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1248
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 3448 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3506

Query: 1249 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1308
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 3507 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3559

Query: 1309 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R
Sbjct: 3560 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKR 3615



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 56/223 (25%), Positives = 95/223 (42%), Gaps = 26/223 (11%)

Query: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1202
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 4396 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4448

Query: 1203 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1258
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 4449 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4505

Query: 1259 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1318
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4556

Query: 1319 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1361
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R
Sbjct: 4557 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4599



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 1213 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1272
            L  +  +K+  ++  +   Q A+E   A  + L++     AT  +        + ++ Q 
Sbjct: 2589 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-ATKWQQTPAPTDTEAVKTQV 2647

Query: 1273 EAQQPTFDA-LRDELRGAQEVGERLQQRHGERD--VEVERWRERVAQLLERWQAVLAQTD 1329
            E Q  +F+A L+  +   QE+ ++L +   E     E  RW++ + ++  +WQ +   T 
Sbjct: 2648 E-QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2706

Query: 1330 VRQRELEQLGRQLRYYRESADPLGAWL 1356
             RQ++LE+    L  ++     L  WL
Sbjct: 2707 DRQQKLEESSNNLTQFQTVEAQLKQWL 2733



 Score = 35.4 bits (80), Expect = 0.38
 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)

Query: 497  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDI 556
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 4771 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4823

Query: 557  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 616
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 4824 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4869

Query: 617  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 668
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 4870 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4927

Query: 669  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLG 728
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 4928 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4982

Query: 729  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 774
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+  + 
Sbjct: 4983 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 5038

Query: 775  FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 821
            F     D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 5039 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 5087



 Score = 34.7 bits (78), Expect = 0.64
 Identities = 77/390 (19%), Positives = 150/390 (38%), Gaps = 56/390 (14%)

Query: 996  QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1055
            Q V+  + +   + + +V++   L +D   L    + R+ VQ++    L  F T KP+ +
Sbjct: 2723 QTVEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQIL----LQEFATRKPQYE 2775

Query: 1056 RQALHSLELHYQAFL-RDSQDAG--GFGPEDRLMAEREY----GSCSHHYQQLLQSLEQG 1108
            +     L    Q  L R  +D    G   E      +++    G  S     + Q++ + 
Sbjct: 2776 Q-----LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2830

Query: 1109 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1168
             Q +S  +    +L D+  +L +    + H   +    E A++  Q I +Q+K Q +V  
Sbjct: 2831 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI-QQEKKQIKVA- 2888

Query: 1169 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1228
                     A  E + AL +       L  +LE  L   + V   +  +++ L++     
Sbjct: 2889 --------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2940

Query: 1229 RGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KASLKKLRAQAEAQQPTF- 1279
               Q      +A  +  KE Q     + A L  LE+     K   K L AQ+   + T  
Sbjct: 2941 HQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIA 3000

Query: 1280 --DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
              + L  + +G+++   +LQ                +  +   W     Q   R+ +L++
Sbjct: 3001 EGENLLLKTQGSEKAALQLQ----------------LNTIKTNWDTFNKQVKERENKLKE 3044

Query: 1338 LGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
               +   Y+E  + L  W+   +   E+I+
Sbjct: 3045 SLEKALKYKEQVETLWPWIDKCQNNLEEIK 3074



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)

Query: 638  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 690
            +V  + V+R   L+D+  R  Q       L+ W+EE++  +D   E   D   ++ QL  
Sbjct: 4779 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4838

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 745
            H+   +S+    +  +        L   T  A       D L  L  ++  +   S  R 
Sbjct: 4839 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4898

Query: 746  RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 797
              LE    F    T  L     WL   E    E++      D   N+    +++ A  +E
Sbjct: 4899 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4955

Query: 798  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 857
            L  +   ++ L+ +   L+         V+     L T+W  +  L    +  L+     
Sbjct: 4956 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 5015

Query: 858  FQFFSDVREA 867
             + F  V  A
Sbjct: 5016 AEEFHSVVHA 5025



 Score = 32.3 bits (72), Expect = 3.2
 Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 29/142 (20%)

Query: 415  QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 474
            QE  E +L  LQW        ++   P   EE++ L ++   F E E+  K+ D ++   
Sbjct: 5129 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFME-EMTRKQPDVDKVTK 5187

Query: 475  IYQ-------SLEGAV------QAGQLKVP-----PGYHPLDVE----------KEWGKL 506
             Y+       SL+  +      +AG+ + P     P      +E           +W ++
Sbjct: 5188 TYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQV 5247

Query: 507  HVAILEREKQLRSEFERLECLQ 528
             +  LER ++L    +RLE L+
Sbjct: 5248 WLLALERRRKLNDALDRLEELR 5269


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  667 bits (1721), Expect = 0.0
 Identities = 314/717 (43%), Positives = 503/717 (70%)

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ 
Sbjct: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RK SCDRS+++
Sbjct: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+E  +   R+E Q+Q
Sbjct: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ
Sbjct: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1317



 Score =  560 bits (1444), Expect = e-159
 Identities = 269/450 (59%), Positives = 360/450 (80%), Gaps = 1/450 (0%)

Query: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230
           DERD+VQKKT TKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 31  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 90

Query: 231 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290
           H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 91  HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 150

Query: 291 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350
           M+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V  Q+NL 
Sbjct: 151 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 210

Query: 351 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
           NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP+  +G+ AN++
Sbjct: 211 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 269

Query: 411 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
           +++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE E+P KE +K+
Sbjct: 270 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 329

Query: 471 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
           + K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 330 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 389

Query: 531 VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
             ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++R    DVQ
Sbjct: 390 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 449

Query: 591 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620
            L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 450 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 479



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 154/796 (19%), Positives = 310/796 (38%), Gaps = 129/796 (16%)

Query: 645  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 697
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355

Query: 698  IEEFQAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414

Query: 754  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 807
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474

Query: 808  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 846
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532

Query: 847  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKNSCDRSATVTRLED 895
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591

Query: 896  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 943
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651

Query: 944  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 997
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710

Query: 998  VQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1052
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770

Query: 1053 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1096
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830

Query: 1097 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1145
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890

Query: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1205
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948

Query: 1206 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1261
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998

Query: 1262 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1319
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051

Query: 1320 RWQAVLAQTDVRQREL 1335
             W+ +    + R+ +L
Sbjct: 4052 IWENIHTLVEEREAKL 4067



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 60/296 (20%), Positives = 122/296 (41%), Gaps = 35/296 (11%)

Query: 1083 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1136
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218

Query: 1137 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1188
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269

Query: 1189 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1248
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328

Query: 1249 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1308
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381

Query: 1309 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R
Sbjct: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKR 3437



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 56/223 (25%), Positives = 95/223 (42%), Gaps = 26/223 (11%)

Query: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1202
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270

Query: 1203 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1258
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327

Query: 1259 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1318
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378

Query: 1319 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1361
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R
Sbjct: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 1213 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1272
            L  +  +K+  ++  +   Q A+E   A  + L++     AT  +        + ++ Q 
Sbjct: 2411 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-ATKWQQTPAPTDTEAVKTQV 2469

Query: 1273 EAQQPTFDA-LRDELRGAQEVGERLQQRHGERD--VEVERWRERVAQLLERWQAVLAQTD 1329
            E Q  +F+A L+  +   QE+ ++L +   E     E  RW++ + ++  +WQ +   T 
Sbjct: 2470 E-QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2528

Query: 1330 VRQRELEQLGRQLRYYRESADPLGAWL 1356
             RQ++LE+    L  ++     L  WL
Sbjct: 2529 DRQQKLEESSNNLTQFQTVEAQLKQWL 2555



 Score = 35.4 bits (80), Expect = 0.38
 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)

Query: 497  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDI 556
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645

Query: 557  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 616
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691

Query: 617  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 668
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749

Query: 669  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLG 728
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804

Query: 729  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 774
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+  + 
Sbjct: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4860

Query: 775  FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 821
            F     D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 4861 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909



 Score = 34.7 bits (78), Expect = 0.64
 Identities = 77/390 (19%), Positives = 150/390 (38%), Gaps = 56/390 (14%)

Query: 996  QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1055
            Q V+  + +   + + +V++   L +D   L    + R+ VQ++    L  F T KP+ +
Sbjct: 2545 QTVEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQIL----LQEFATRKPQYE 2597

Query: 1056 RQALHSLELHYQAFL-RDSQDAG--GFGPEDRLMAEREY----GSCSHHYQQLLQSLEQG 1108
            +     L    Q  L R  +D    G   E      +++    G  S     + Q++ + 
Sbjct: 2598 Q-----LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2652

Query: 1109 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1168
             Q +S  +    +L D+  +L +    + H   +    E A++  Q I +Q+K Q +V  
Sbjct: 2653 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI-QQEKKQIKVA- 2710

Query: 1169 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1228
                     A  E + AL +       L  +LE  L   + V   +  +++ L++     
Sbjct: 2711 --------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2762

Query: 1229 RGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KASLKKLRAQAEAQQPTF- 1279
               Q      +A  +  KE Q     + A L  LE+     K   K L AQ+   + T  
Sbjct: 2763 HQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIA 2822

Query: 1280 --DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
              + L  + +G+++   +LQ                +  +   W     Q   R+ +L++
Sbjct: 2823 EGENLLLKTQGSEKAALQLQ----------------LNTIKTNWDTFNKQVKERENKLKE 2866

Query: 1338 LGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
               +   Y+E  + L  W+   +   E+I+
Sbjct: 2867 SLEKALKYKEQVETLWPWIDKCQNNLEEIK 2896



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)

Query: 638  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 690
            +V  + V+R   L+D+  R  Q       L+ W+EE++  +D   E   D   ++ QL  
Sbjct: 4601 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4660

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 745
            H+   +S+    +  +        L   T  A       D L  L  ++  +   S  R 
Sbjct: 4661 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4720

Query: 746  RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 797
              LE    F    T  L     WL   E    E++      D   N+    +++ A  +E
Sbjct: 4721 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4777

Query: 798  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 857
            L  +   ++ L+ +   L+         V+     L T+W  +  L    +  L+     
Sbjct: 4778 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837

Query: 858  FQFFSDVREA 867
             + F  V  A
Sbjct: 4838 AEEFHSVVHA 4847



 Score = 32.3 bits (72), Expect = 3.2
 Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 29/142 (20%)

Query: 415  QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 474
            QE  E +L  LQW        ++   P   EE++ L ++   F E E+  K+ D ++   
Sbjct: 4951 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFME-EMTRKQPDVDKVTK 5009

Query: 475  IYQ-------SLEGAV------QAGQLKVP-----PGYHPLDVE----------KEWGKL 506
             Y+       SL+  +      +AG+ + P     P      +E           +W ++
Sbjct: 5010 TYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQV 5069

Query: 507  HVAILEREKQLRSEFERLECLQ 528
             +  LER ++L    +RLE L+
Sbjct: 5070 WLLALERRRKLNDALDRLEELR 5091


>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
          Length = 3062

 Score =  667 bits (1721), Expect = 0.0
 Identities = 314/717 (43%), Positives = 503/717 (70%)

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RK SCDRS+++
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+E  +   R+E Q+Q
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ
Sbjct: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 523 RLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMI 582
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115

Query: 583 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  667 bits (1721), Expect = 0.0
 Identities = 314/717 (43%), Positives = 503/717 (70%)

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RK SCDRS+++
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+E  +   R+E Q+Q
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ
Sbjct: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 523 RLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMI 582
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115

Query: 583 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 154/796 (19%), Positives = 310/796 (38%), Gaps = 129/796 (16%)

Query: 645  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 697
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 2970 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3029

Query: 698  IEEFQAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 3030 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3088

Query: 754  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 807
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 3089 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3148

Query: 808  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 846
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 3149 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3206

Query: 847  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKNSCDRSATVTRLED 895
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 3207 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3265

Query: 896  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 943
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 3266 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3325

Query: 944  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 997
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 3326 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3384

Query: 998  VQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1052
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 3385 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3444

Query: 1053 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1096
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 3445 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3504

Query: 1097 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1145
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 3505 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3564

Query: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1205
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 3565 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3622

Query: 1206 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1261
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 3623 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3672

Query: 1262 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1319
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 3673 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 3725

Query: 1320 RWQAVLAQTDVRQREL 1335
             W+ +    + R+ +L
Sbjct: 3726 IWENIHTLVEEREAKL 3741



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 60/296 (20%), Positives = 122/296 (41%), Gaps = 35/296 (11%)

Query: 1083 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1136
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 2835 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 2892

Query: 1137 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1188
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 2893 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 2943

Query: 1189 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1248
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 2944 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3002

Query: 1249 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1308
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 3003 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3055

Query: 1309 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R
Sbjct: 3056 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKR 3111



 Score = 40.4 bits (93), Expect = 0.012
 Identities = 56/223 (25%), Positives = 95/223 (42%), Gaps = 26/223 (11%)

Query: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1202
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 3892 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 3944

Query: 1203 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1258
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 3945 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4001

Query: 1259 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1318
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 4002 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4052

Query: 1319 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1361
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R
Sbjct: 4053 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4095



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 1213 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1272
            L  +  +K+  ++  +   Q A+E   A  + L++     AT  +        + ++ Q 
Sbjct: 2085 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-ATKWQQTPAPTDTEAVKTQV 2143

Query: 1273 EAQQPTFDA-LRDELRGAQEVGERLQQRHGERD--VEVERWRERVAQLLERWQAVLAQTD 1329
            E Q  +F+A L+  +   QE+ ++L +   E     E  RW++ + ++  +WQ +   T 
Sbjct: 2144 E-QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2202

Query: 1330 VRQRELEQLGRQLRYYRESADPLGAWL 1356
             RQ++LE+    L  ++     L  WL
Sbjct: 2203 DRQQKLEESSNNLTQFQTVEAQLKQWL 2229



 Score = 35.4 bits (80), Expect = 0.38
 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)

Query: 497  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDI 556
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 4267 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4319

Query: 557  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 616
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 4320 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4365

Query: 617  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 668
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 4366 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4423

Query: 669  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLG 728
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 4424 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4478

Query: 729  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 774
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+  + 
Sbjct: 4479 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4534

Query: 775  FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 821
            F     D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 4535 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4583



 Score = 34.7 bits (78), Expect = 0.64
 Identities = 77/390 (19%), Positives = 150/390 (38%), Gaps = 56/390 (14%)

Query: 996  QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1055
            Q V+  + +   + + +V++   L +D   L    + R+ VQ++    L  F T KP+ +
Sbjct: 2219 QTVEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQIL----LQEFATRKPQYE 2271

Query: 1056 RQALHSLELHYQAFL-RDSQDAG--GFGPEDRLMAEREY----GSCSHHYQQLLQSLEQG 1108
            +     L    Q  L R  +D    G   E      +++    G  S     + Q++ + 
Sbjct: 2272 Q-----LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2326

Query: 1109 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1168
             Q +S  +    +L D+  +L +    + H   +    E A++  Q I +Q+K Q +V  
Sbjct: 2327 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI-QQEKKQIKVA- 2384

Query: 1169 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1228
                     A  E + AL +       L  +LE  L   + V   +  +++ L++     
Sbjct: 2385 --------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2436

Query: 1229 RGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KASLKKLRAQAEAQQPTF- 1279
               Q      +A  +  KE Q     + A L  LE+     K   K L AQ+   + T  
Sbjct: 2437 HQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIA 2496

Query: 1280 --DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337
              + L  + +G+++   +LQ                +  +   W     Q   R+ +L++
Sbjct: 2497 EGENLLLKTQGSEKAALQLQ----------------LNTIKTNWDTFNKQVKERENKLKE 2540

Query: 1338 LGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
               +   Y+E  + L  W+   +   E+I+
Sbjct: 2541 SLEKALKYKEQVETLWPWIDKCQNNLEEIK 2570



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)

Query: 638  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 690
            +V  + V+R   L+D+  R  Q       L+ W+EE++  +D   E   D   ++ QL  
Sbjct: 4275 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4334

Query: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 745
            H+   +S+    +  +        L   T  A       D L  L  ++  +   S  R 
Sbjct: 4335 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4394

Query: 746  RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 797
              LE    F    T  L     WL   E    E++      D   N+    +++ A  +E
Sbjct: 4395 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4451

Query: 798  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 857
            L  +   ++ L+ +   L+         V+     L T+W  +  L    +  L+     
Sbjct: 4452 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4511

Query: 858  FQFFSDVREA 867
             + F  V  A
Sbjct: 4512 AEEFHSVVHA 4521



 Score = 32.3 bits (72), Expect = 3.2
 Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 29/142 (20%)

Query: 415  QEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKG 474
            QE  E +L  LQW        ++   P   EE++ L ++   F E E+  K+ D ++   
Sbjct: 4625 QELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFME-EMTRKQPDVDKVTK 4683

Query: 475  IYQ-------SLEGAV------QAGQLKVP-----PGYHPLDVE----------KEWGKL 506
             Y+       SL+  +      +AG+ + P     P      +E           +W ++
Sbjct: 4684 TYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQV 4743

Query: 507  HVAILEREKQLRSEFERLECLQ 528
             +  LER ++L    +RLE L+
Sbjct: 4744 WLLALERRRKLNDALDRLEELR 4765


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score =  667 bits (1721), Expect = 0.0
 Identities = 314/717 (43%), Positives = 503/717 (70%)

Query: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RK SCDRS+++
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+E  +   R+E Q+Q
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814

Query: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874

Query: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934

Query: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ
Sbjct: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 523 RLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMI 582
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115

Query: 583 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153



 Score = 35.0 bits (79), Expect = 0.49
 Identities = 30/115 (26%), Positives = 57/115 (49%), Gaps = 11/115 (9%)

Query: 1236 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1295
            ++L+  +  + E   +   + ELE   A LKK +++ E + P       ++R A E   R
Sbjct: 1121 DLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELP-------KVREAAENELR 1173

Query: 1296 LQQRHGERDVEVERWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRES 1348
             QQR+ E D+ +++ R      Q     + ++ + +  +RELE++ RQL    E+
Sbjct: 1174 KQQRNVE-DISLQKIRAESEAKQYRRELETIVREKEAAERELERV-RQLTIEAEA 1226



 Score = 35.0 bits (79), Expect = 0.49
 Identities = 62/264 (23%), Positives = 103/264 (39%), Gaps = 44/264 (16%)

Query: 693  GLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRL----DLQYAKLLNSSKARLRS- 747
            GL Q  E  + K E  +    +L+ A R A +D          LQ  K  +  KARL   
Sbjct: 1351 GLQQ--EHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKD 1408

Query: 748  -LESLHSFVAAATKELMWLNEKEEEEVGFDWS----DRNTNMTAKK-----ESYSALMR- 796
             L+  ++ +     EL     K++ E G+        R  N T  K     +  S L + 
Sbjct: 1409 KLDETNNTLRCLKLEL---ERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKI 1465

Query: 797  ------ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQT----QWSWMLQLCCC 846
                  ELE    +  +LQ   DR+ R    A   ++   + + +    +    LQ+C  
Sbjct: 1466 KRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQR 1525

Query: 847  IEAHLKEN--AAYFQFFSDVR---EAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQ 901
               HLKE    ++ Q   +++   E   ++Q+L E L + N C         E L Q  +
Sbjct: 1526 KSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNEC--------AEMLKQKVE 1577

Query: 902  DEKEQLNEYKGHLSGLAKRAKAVV 925
            +   Q NE K  +  +   ++ +V
Sbjct: 1578 ELTRQNNETKLMMQRIQAESENIV 1601



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 100/453 (22%), Positives = 170/453 (37%), Gaps = 85/453 (18%)

Query: 892  RLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV 951
            + + L++  Q+   Q++     L G+ K  K       R   HP+   +        +QV
Sbjct: 937  KADQLVERWQNVHVQIDNRLRDLEGIGKSLKYY-----RDTYHPLDDWI--------QQV 983

Query: 952  EVTVHKGDECQLVGPAQPSHWKVLSSS-GSEAAVPSVCFLVPPPNQEVQEAVTRLEA--Q 1008
            E T  K  E       QP + K L++    +  + S   +      E Q+   +  A  +
Sbjct: 984  ETTQRKIQE------NQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK 1037

Query: 1009 HQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQA 1068
               L T+ ++  VD +     +  RR +Q      +  F  L+   +  AL +L   Y  
Sbjct: 1038 DYELQTMTYRAMVDSQQKSPVK--RRRMQSSADLIIQEFMDLRT--RYTALVTLMTQYIK 1093

Query: 1069 FLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 1128
            F  DS          R     E+G+    Y  LLQ  +    E S+    ISEL+ +  +
Sbjct: 1094 FAGDSLKRLEEEEIKRCKETSEHGA----YSDLLQRQKATVLENSKLTGKISELERMVAE 1149

Query: 1129 LEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1188
            L+  ++R    L         RE A+   E +K Q  VE +     R  +EA++      
Sbjct: 1150 LKKQKSRVEEEL------PKVREAAEN--ELRKQQRNVEDISLQKIRAESEAKQ------ 1195

Query: 1189 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1248
                                        Y  +L+TI   +R  + AE  L    +   EA
Sbjct: 1196 ----------------------------YRRELETI---VREKEAAERELERVRQLTIEA 1224

Query: 1249 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1308
            +A  A + E      +L   R Q E    T   L D L+        L+Q+  +   E+ 
Sbjct: 1225 EAKRAAVEE------NLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELR 1278

Query: 1309 RWR---ERVAQLLERWQAVLA-QTDVRQRELEQ 1337
            R R   E + +L+++ +  LA Q  V +++L++
Sbjct: 1279 RKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKE 1311


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score =  460 bits (1183), Expect = e-129
 Identities = 262/862 (30%), Positives = 475/862 (55%), Gaps = 57/862 (6%)

Query: 541  CEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 600
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135

Query: 601  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 657
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187

Query: 658  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSP 717
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI +++ ++++ ++D  + S 
Sbjct: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246

Query: 718  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 777
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298

Query: 778  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 837
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358

Query: 838  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLL 897
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+K  CD++  +  L + +
Sbjct: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418

Query: 898  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 957
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478

Query: 958  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWH 1017
            GDEC L    + S W V    G +  VPSV  ++PPPN    +   ++E  ++A++ LW+
Sbjct: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538

Query: 1018 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1077
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598

Query: 1078 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1117
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658

Query: 1118 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1167
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715

Query: 1168 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1227
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773

Query: 1228 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1287
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833

Query: 1288 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1347
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893

Query: 1348 SADPLGAWLQDARRRQEQIQAM 1369
            +      WL DA+RRQ+ +++M
Sbjct: 894  NYQAFCKWLYDAKRRQDSLESM 915



 Score = 34.7 bits (78), Expect = 0.64
 Identities = 66/341 (19%), Positives = 133/341 (39%), Gaps = 51/341 (14%)

Query: 1029 WQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLR---------DSQDAGGF 1079
            WQ + + +   R W L        E+Q + L +   +YQAF +         DS ++  F
Sbjct: 867  WQRIDKQIDF-RLWDL--------EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917

Query: 1080 GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR 1139
            G  + +M  R      + + ++    ++  + +   + C + +KD  LQL +  +     
Sbjct: 918  GDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETL 975

Query: 1140 LRLPLDK----EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAP 1194
            L +P+ +     P+    Q  A+      E+        R  +E  K L  L   +    
Sbjct: 976  LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIE 1035

Query: 1195 TLRSELELTLG--------------KLEQVRSLSAIYLEKLKTISLVIRGTQ----GAEE 1236
             L  EL L                  L++ ++  + +  KL ++  + R  +     A++
Sbjct: 1036 VLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQ 1095

Query: 1237 VLRAHEEQLKEA-QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1295
             L     Q+KE  + +     E+E  K   K +  + + Q+  +D L       Q+  + 
Sbjct: 1096 NLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL-------QKARQC 1148

Query: 1296 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1336
             ++  G + +E E+  +     +ER + +L +   R+RE E
Sbjct: 1149 EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYE 1189


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score =  460 bits (1183), Expect = e-129
 Identities = 262/862 (30%), Positives = 475/862 (55%), Gaps = 57/862 (6%)

Query: 541  CEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 600
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135

Query: 601  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 657
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187

Query: 658  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSP 717
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI +++ ++++ ++D  + S 
Sbjct: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246

Query: 718  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 777
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298

Query: 778  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 837
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358

Query: 838  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLL 897
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+K  CD++  +  L + +
Sbjct: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418

Query: 898  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 957
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478

Query: 958  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWH 1017
            GDEC L    + S W V    G +  VPSV  ++PPPN    +   ++E  ++A++ LW+
Sbjct: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538

Query: 1018 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1077
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598

Query: 1078 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1117
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658

Query: 1118 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1167
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715

Query: 1168 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1227
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773

Query: 1228 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1287
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833

Query: 1288 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1347
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893

Query: 1348 SADPLGAWLQDARRRQEQIQAM 1369
            +      WL DA+RRQ+ +++M
Sbjct: 894  NYQAFCKWLYDAKRRQDSLESM 915



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 142/784 (18%), Positives = 309/784 (39%), Gaps = 110/784 (14%)

Query: 640  TLQSVQRRPELEDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI 698
            +L+ ++R+ EL+  + +  L      ++E   ++    + ++           +   +S+
Sbjct: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIE---------DEKRRRKSV 1128

Query: 699  EEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAA 758
            E+   + ++ ++D  QL  A R   ++ LG   L+  K +   +  +  L  L       
Sbjct: 1129 ED---RFDQQKNDYDQLQKA-RQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184

Query: 759  TKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY----SALMRELEL-KEKKIKELQNAGD 813
             +E     E E  +V   +++  +N+  K E+        ++E+ + KE   K L+N  D
Sbjct: 1185 KREY----ENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLD 1240

Query: 814  RLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQK 873
            RL RE+   +  +     ++        Q     E  L++ A   +     +  E +L++
Sbjct: 1241 RLSRENRDLKDEIVRLNDSILQATE---QRRRAEENALQQKACGSEIMQKKQHLEIELKQ 1297

Query: 874  LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPA 933
            + +     N+  + +    LE+  +  QD+ +++   K      AKR     + +  +  
Sbjct: 1298 VMQQRSEDNARHKQS----LEEAAKTIQDKNKEIERLKAEFQEEAKR-----RWEYENEL 1348

Query: 934  HPMRGRL--PLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLV 991
              +R      ++++ +  + E+ + K    QL      +  K   +SG  A + ++    
Sbjct: 1349 SKVRNNYDEEIISLKNQFETEINITKTTIHQL------TMQKEEDTSGYRAQIDNLTREN 1402

Query: 992  PPPNQE-----------------VQEAVTRLEAQHQALVTLWHQLHVDMK---------S 1025
               ++E                 V+E + + +A    +     QL V+++         S
Sbjct: 1403 RSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEES 1462

Query: 1026 LLAWQSLRRDVQLIRSWSLATFRTL----KPEEQRQALHSLELHYQAFLRDSQDAGGFGP 1081
            +   QSL    + I+  +    R      K    R+ L       Q    D Q A     
Sbjct: 1463 VRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSAT 1522

Query: 1082 E--DRL-MAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 1138
            E  ++L + E+E       Y+++ Q      Q+ +R Q   + LK+++LQ +  E   ++
Sbjct: 1523 ETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQ---NSLKELQLQKQKVE-EELN 1578

Query: 1139 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1198
            RL+        R  ++   +++K + E+EG+ +    L  +A K+  L +    A  ++ 
Sbjct: 1579 RLK--------RTASEDSCKRKKLEEELEGMRRS---LKEQAIKITNLTQQLEQASIVKK 1627

Query: 1199 ELELTLGKLEQVRSLSAIYL-------EKLKTISLVIRG-----TQGAEEVLRAHEEQLK 1246
              E     L Q R +   +L       E+L+ +S  +        Q  E V +AH     
Sbjct: 1628 RSE---DDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684

Query: 1247 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1306
              +A+      L  +K  +++L++  E        L +ELR  +   + L++   E D +
Sbjct: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744

Query: 1307 ----VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362
                +   R ++     R   +    +  QRE E L +++  +++ A      +Q+++ +
Sbjct: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804

Query: 1363 QEQI 1366
              Q+
Sbjct: 1805 CTQV 1808



 Score = 38.5 bits (88), Expect = 0.045
 Identities = 46/187 (24%), Positives = 85/187 (45%), Gaps = 13/187 (6%)

Query: 735  AKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSD----RNTNMTAKKES 790
            ++ LN SK  +  L+SL   +   TKE + L E+E   +  ++ D    R+   + K  +
Sbjct: 1693 SRSLNESKIEIERLQSLTENL---TKEHLML-EEELRNLRLEYDDLRRGRSEADSDKNAT 1748

Query: 791  YSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ-AALQTQWSWMLQLCCCIEA 849
               L  +L++   +  ELQ   + L RE    R  +E FQ  AL+           C + 
Sbjct: 1749 ILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQV 1808

Query: 850  HLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQ-DAQDEKEQLN 908
             ++E  +       + + + +LQ+L++ L R  S   +   TR++  L+ + Q  +  LN
Sbjct: 1809 -VQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAE--TRVKQRLECEKQQIQNDLN 1865

Query: 909  EYKGHLS 915
            ++K   S
Sbjct: 1866 QWKTQYS 1872



 Score = 37.4 bits (85), Expect = 0.099
 Identities = 70/358 (19%), Positives = 140/358 (39%), Gaps = 52/358 (14%)

Query: 1029 WQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLR---------DSQDAGGF 1079
            WQ + + +   R W L        E+Q + L +   +YQAF +         DS ++  F
Sbjct: 867  WQRIDKQIDF-RLWDL--------EKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKF 917

Query: 1080 GPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHR 1139
            G  + +M  R      + + ++    ++  + +   + C + +KD  LQL +  +     
Sbjct: 918  GDSNTVM--RFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETL 975

Query: 1140 LRLPLDK----EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA-LPEPSPAAP 1194
            L +P+ +     P+    Q  A+      E+        R  +E  K L  L   +    
Sbjct: 976  LNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIE 1035

Query: 1195 TLRSELELTLG--------------KLEQVRSLSAIYLEKLKTISLVIRGTQ----GAEE 1236
             L  EL L                  L++ ++  + +  KL ++  + R  +     A++
Sbjct: 1036 VLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQ 1095

Query: 1237 VLRAHEEQLKEA-QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1295
             L     Q+KE  + +     E+E  K   K +  + + Q+  +D L       Q+  + 
Sbjct: 1096 NLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL-------QKARQC 1148

Query: 1296 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE-QLGRQLRYYRESADPL 1352
             ++  G + +E E+  +     +ER + +L +   R+RE E +L +   +Y E    L
Sbjct: 1149 EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNL 1206



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 121/554 (21%), Positives = 216/554 (38%), Gaps = 50/554 (9%)

Query: 292  TAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLEN 351
            T   +L +  +    GY+  + DN T   R+ R  +  I R K  L    +  R+   E+
Sbjct: 1375 TTIHQLTMQKEEDTSGYRA-QIDNLT---RENRSLSEEIKRLKNTLTQTTENLRRVE-ED 1429

Query: 352  LDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQ 411
            + Q  +         + L+ E   V Q   +  + Y  SL DA   + D    +   + Q
Sbjct: 1430 IQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLK-Q 1488

Query: 412  LRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNR 471
            L  +E  +   L  +  R     ++ ++  SS  E        LK +E EL     D  R
Sbjct: 1489 LIDKETNDRKCLEDENARLQRVQYDLQKANSSATET----INKLKVQEQELTRLRIDYER 1544

Query: 472  SKGIYQSLEGAVQAGQLKVPP-GYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
                    +  +   Q  +         VE+E  +L     E   + +   E LE ++R 
Sbjct: 1545 VSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRS 1604

Query: 531  VTKLQMEAGLCEEQLHQA--------DALLQSDIRLLAAGKVPQRAGEVERDLD-KADSM 581
            + +  ++     +QL QA        D L Q    L    +  QR  E  R L  + +++
Sbjct: 1605 LKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEAL 1664

Query: 582  IRLLFNDVQTLKDGRHPQGEQMYRRVY----RLHERLVAIR-----TEYNLRLKAGVAAP 632
             R L  + +++K   H + E   + +      L+E  + I      TE NL  +  +   
Sbjct: 1665 RRQLLQEQESVKQA-HLRNEHFQKAIEDKSRSLNESKIEIERLQSLTE-NLTKEHLMLEE 1722

Query: 633  ATQVAQVTLQSVQR-RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSH 691
              +  ++    ++R R E +      + +L + ++ + +R       ++L  +   L   
Sbjct: 1723 ELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRT------LELQGLINDLQRE 1776

Query: 692  R-GLHQSIEEFQAKIERA--RSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL 748
            R  L Q IE+FQ +   A  R  E +         R+ L    L   K+L   KARL+ L
Sbjct: 1777 RENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESL----LVKIKVLEQDKARLQRL 1832

Query: 749  ES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 804
            E       S + A T+    L E E++++  D +   T  + K+E+   +  E E  E++
Sbjct: 1833 EDELNRAKSTLEAETRVKQRL-ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSERE 1891

Query: 805  IKELQNAGDRLLRE 818
               L++  +RL  E
Sbjct: 1892 KNSLRSEIERLQAE 1905



 Score = 32.0 bits (71), Expect = 4.2
 Identities = 47/247 (19%), Positives = 104/247 (42%), Gaps = 16/247 (6%)

Query: 1099 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1158
            +QLLQ  E   Q   R +     ++D    L   +   + RL+  L +   +E      E
Sbjct: 1666 RQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIE-IERLQ-SLTENLTKEHLMLEEE 1723

Query: 1159 QQKAQAEVEGLGKGVARLSAEAEK---VLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1215
             +  + E + L +G  R  A+++K   +L L      +     EL+  +  L++ R    
Sbjct: 1724 LRNLRLEYDDLRRG--RSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLR 1781

Query: 1216 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ 1275
              +EK +  +L    +   +E      + ++E +++   +  LE  KA L++L  +    
Sbjct: 1782 QEIEKFQKQAL--EASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRA 1839

Query: 1276 QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQREL 1335
            + T +A          V +RL+    +   ++ +W+ + ++  E  + + ++ +  +RE 
Sbjct: 1840 KSTLEA-------ETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK 1892

Query: 1336 EQLGRQL 1342
              L  ++
Sbjct: 1893 NSLRSEI 1899


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score =  351 bits (900), Expect = 3e-96
 Identities = 338/1225 (27%), Positives = 527/1225 (43%), Gaps = 165/1225 (13%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229
            DER+ VQKKT TKWVN HL +    + DLY DLRDG NL+ LLEVLSG+ LP+  KGRMR
Sbjct: 53   DEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMR 112

Query: 230  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288
             H L+NV  AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V  +  
Sbjct: 113  IHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDN 172

Query: 289  -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347
             E  +AK+ LLLW Q    GY  +   NFT+SWRDG  FNAI+H+H+P L+D   + +  
Sbjct: 173  KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCN 232

Query: 348  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406
               NL  AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y    ++  +  +G R
Sbjct: 233  AHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKR 292

Query: 407  -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459
                   A E +   ++Y  L   LLQW+        +R+  +S   ++     F  ++ 
Sbjct: 293  IGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRT 352

Query: 460  MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 516
            +E P K  +K   + +  +++  ++A   KV     G    D+ K W +L  A  ERE  
Sbjct: 353  VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELA 412

Query: 517  LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573
            LR+E  R E L+++  +   +A + E  L +   L+  D   + L A     ++   +E 
Sbjct: 413  LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472

Query: 574  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 633
            D       I      VQ +         + Y  + R+  R   +   ++   +   A   
Sbjct: 473  D-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRE 525

Query: 634  TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 693
              +  + LQ V +        L YL D   W+EE + R+   + G  L  VE  L  H  
Sbjct: 526  RLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVEDLLQLHEL 575

Query: 694  LHQSIEEFQAKIERARSDEGQLSPATRGAYRDC--------LGRLDLQY---AKLLNSSK 742
            +   I   QA+  RA S            YR C        + +L+  Y    +L  + +
Sbjct: 576  VEADI-AVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARR 634

Query: 743  ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE 802
            ARL     L  F+    +   W+ E++      D     T        ++AL  E+  + 
Sbjct: 635  ARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRL 694

Query: 803  KKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS 862
              +K     G +L+ E HP      +  A LQ QW  +  L       L + A+ +QF +
Sbjct: 695  GPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQA 754

Query: 863  DVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK 922
            D  + E     L +ALR  +S +        + L +  +  +E++  ++  L  L ++A 
Sbjct: 755  DANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAA 811

Query: 923  AVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEA 982
            A+     R P   ++GR+P L   +    E+    G+  + +  A  + + +LS +G+  
Sbjct: 812  ALPPTLSRTP--EVQGRVPTL---ERHYEELQARAGERARAL-EAALALYTMLSEAGA-- 863

Query: 983  AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
                                            LW +      + LA      D+++++  
Sbjct: 864  ------------------------------CGLWVEEKEQWLNGLALPERLEDLEVVQQ- 892

Query: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102
                F TL+PE    A     ++  A      +  G   +DR++  +E    +H +QQ  
Sbjct: 893  ---RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQE--QLNHRWQQ-F 943

Query: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKA 1162
            + L  G +         S L      LE  ET+   R                  E+ K 
Sbjct: 944  RRLADGKK-----AALTSALSIQNYHLECTETQAWMR------------------EKTKV 980

Query: 1163 QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1222
                +GLG  +A + A   K+        A      EL        +  +L+A +  +  
Sbjct: 981  IESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TREANALAAGHPAQAV 1034

Query: 1223 TISLVIRGTQGAEEVLRA----HEEQLKEAQAV--------------------------P 1252
             I+  +R  Q   E LRA     EE L EA+ +                          P
Sbjct: 1035 AINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGP 1094

Query: 1253 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1312
            ATLPE EA  A    LR + E  Q  +  LR        +GE + +   + D +    R+
Sbjct: 1095 ATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR--DQADPQCLFLRQ 1145

Query: 1313 RVAQLLERWQAVLAQTDVRQRELEQ 1337
            R+  L   W+ +    + RQ  L Q
Sbjct: 1146 RLEALGTGWEELGRMWESRQGRLAQ 1170



 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 163/819 (19%), Positives = 299/819 (36%), Gaps = 151/819 (18%)

Query: 296  KLLLWSQRMVEGYQGLRCD---NFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 352
            +L LW    +   Q +  D   N  + W+  + F A +  +K  L  ++K  R+  LE  
Sbjct: 1289 ELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP 1348

Query: 353  DQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQL 412
            +    V+E+   + R  D          E +      SL+DA             N  +L
Sbjct: 1349 ELKALVSEKLRDLHRRWDEL--------ETTTQAKARSLFDA-------------NRAEL 1387

Query: 413  RWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL--------WSQFLKFKEMELPA 464
                + +    L  W+    A      +      + IL        W   ++ KE+E   
Sbjct: 1388 ----FAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE--- 1440

Query: 465  KEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL 524
              A + ++K + Q  +GA +  +           VE+++  L   + ER ++L++  E+ 
Sbjct: 1441 --AIQAQAKALAQEDQGAGEVERTSRA-------VEEKFRALCQPMRERCRRLQASREQ- 1490

Query: 525  ECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRL 584
                                 HQ    ++ +I L    ++P  A  +E   D     ++L
Sbjct: 1491 ---------------------HQFHRDVEDEI-LWVTERLPM-ASSMEHGKDLPS--VQL 1525

Query: 585  LFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSV 644
            L    QTL+  +  QG          HE  +A   E    L A  A P     Q   + +
Sbjct: 1526 LMKKNQTLQ--KEIQG----------HEPRIADLRERQRALGAAAAGPELAELQEMWKRL 1573

Query: 645  QRRPELEDSTL----------RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGL 694
                EL    L          R   +  AW+ E +  + G E   D  S +A++  H+ L
Sbjct: 1574 GHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVL 1633

Query: 695  HQSIEEFQAKIER-ARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 749
             Q++ ++   I + A S +  +      +TR + R    ++D  YA L   +  R   L+
Sbjct: 1634 EQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQA--QVDKLYAGLKELAGERRERLQ 1691

Query: 750  SLHSFVAAATKEL----MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE-LKEKK 804
              H  +    +EL     W+ E+E      +      ++T  ++ +    R+   + +++
Sbjct: 1692 E-HLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQER 1750

Query: 805  IKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDV 864
            +       + L+   H AR TV  ++ +L   W+ +L+L       L       +F    
Sbjct: 1751 VDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGA 1810

Query: 865  REAEGQLQKLQ--------------EALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNE- 909
            R+A  ++Q  Q              EAL+R++ C     +  L   +Q  QD+  +L + 
Sbjct: 1811 RQALARVQHKQQQLPDGTGRDLNAAEALQRRH-CAYEHDIQALSPQVQQVQDDGHRLQKA 1869

Query: 910  YKG-HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCD----YKQVEVTVHKGDECQLV 964
            Y G     + +  +AV +   +        R  LL   D    +K V   +   DE  L 
Sbjct: 1870 YAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQ 1929

Query: 965  GPAQPSHWKVLSS-------SGSEAAVP------SVCFLVPP--------PNQEVQEAVT 1003
              AQ     V S+        G +A +       S C  +            +E+ E ++
Sbjct: 1930 MDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLS 1989

Query: 1004 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042
            +L+A+ Q     W +    ++ +L      RD  +  +W
Sbjct: 1990 QLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAW 2028



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 142/732 (19%), Positives = 252/732 (34%), Gaps = 118/732 (16%)

Query: 655  LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS---- 710
            LR L D  AW+   Q  V   E    LP  EA L  H  L   +E  Q++  R R+    
Sbjct: 1071 LRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEE 1130

Query: 711  ---DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNE 767
               D+            + LG    +  ++  S + RL        F+  A +    L+ 
Sbjct: 1131 VTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSS 1190

Query: 768  KEEEEVGFDWSDRNTNMTAKKESYSALMRELE-------LKEKKIKELQNAGDRLLREDH 820
            +E       +   +T M    ++  A +++LE          ++I  L  AG +L+ E +
Sbjct: 1191 QE-------YVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGN 1243

Query: 821  PARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRR 880
                 +     +++ +             H K   A  QF   +R+   Q   LQ+    
Sbjct: 1244 IHADKIREKADSIERR-------------HKKNQDAAQQFLGRLRDNREQQHFLQDCHEL 1290

Query: 881  KNSCDRSATVTRLEDLLQDAQDEKEQLN-EYKGHLSGLAKRAKAVVQL-KPRHPAHPMRG 938
            K   D      +       + DE   L+ +++ H + +A+ A     L K       +  
Sbjct: 1291 KLWIDEKMLTAQ-----DVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTL 1345

Query: 939  RLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEV 998
              P L     +++     + DE +    A+     +  ++ +E    S C          
Sbjct: 1346 EKPELKALVSEKLRDLHRRWDELETTTQAKAR--SLFDANRAELFAQSCC---------- 1393

Query: 999  QEAVTRLEAQHQALVTLWHQLHVD--MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQR 1056
                    A    L +L  QLH D   K L +   L +  Q++  W +A         + 
Sbjct: 1394 --------ALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML-EWEMAV--------RE 1436

Query: 1057 QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQ 1116
            + + +++   +A  ++ Q AG            E    S   ++  ++L Q  +E  R  
Sbjct: 1437 KEVEAIQAQAKALAQEDQGAG------------EVERTSRAVEEKFRALCQPMRERCRRL 1484

Query: 1117 RCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ---RIAEQQKAQAEVEGLGKGV 1173
            +   E       +E        RL +    E  ++       + + Q  Q E++G    +
Sbjct: 1485 QASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRI 1544

Query: 1174 ARLSAEAEKVLALPEPSPAAPTLRS-------ELELTLGKLEQVRSLSAIYLEKLKTISL 1226
            A L  E ++ L      P    L+        ELEL   +LE        Y +  +    
Sbjct: 1545 ADL-RERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA--- 1600

Query: 1227 VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDEL 1286
                  G +E+    +E+ K+         EL A        +A+ +  Q    AL D  
Sbjct: 1601 --EAWMGEQELHMMGQEKAKD---------ELSA--------QAEVKKHQVLEQALADYA 1641

Query: 1287 RGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR 1346
            +   ++    Q        E  R   R AQ +++  A L +    +RE  Q   +L   R
Sbjct: 1642 QTIHQLAASSQDMIDHEHPESTRISIRQAQ-VDKLYAGLKELAGERRERLQEHLRLCQLR 1700

Query: 1347 ESADPLGAWLQD 1358
               D L  W+Q+
Sbjct: 1701 RELDDLEQWIQE 1712



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 88/420 (20%), Positives = 151/420 (35%), Gaps = 42/420 (10%)

Query: 508  VAILER---EKQLRSEFERLECLQRIVTKLQM--EAGLC----EEQLHQADALLQSDIRL 558
            V  LER   E Q R+  ER   L+  +    M  EAG C    EE+    + L   + RL
Sbjct: 827  VPTLERHYEELQARAG-ERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPE-RL 884

Query: 559  LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 618
                 V QR   +E +++   + I  + +  + L     P  +++     +L+ R    R
Sbjct: 885  EDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFR 944

Query: 619  TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW- 677
                 RL  G  A  T    +    ++              +  AW+ E    ++  +  
Sbjct: 945  -----RLADGKKAALTSALSIQNYHLE------------CTETQAWMREKTKVIESTQGL 987

Query: 678  GVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLS---PATRGAYRDCLGRLDLQY 734
            G DL  V A      G  + +E   A++     +   L+   PA   A    L  +   +
Sbjct: 988  GNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGW 1047

Query: 735  AKLLNSSKARLRSL---ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 791
              L  + + R  SL     L  F+ +      WL   +      +         A    +
Sbjct: 1048 EDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQH 1107

Query: 792  SALMRELELKEKKIKELQNAGDRLLRED-HPARPTVESFQAALQTQWSWMLQLCCCIEAH 850
            +AL  E+E  + +   L+  G+ + R+   P    +     AL T W  + ++    +  
Sbjct: 1108 AALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGR 1167

Query: 851  LKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCD----RSATVTRLEDLL--QDAQDEK 904
            L +   +  F  D R+AEG L   +  L             A + +LED +   DA  E+
Sbjct: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGER 1227


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
            sapiens]
          Length = 2155

 Score =  338 bits (868), Expect = 2e-92
 Identities = 329/1293 (25%), Positives = 558/1293 (43%), Gaps = 154/1293 (11%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229
            DER+ VQKKT TKWVN HL +    I+DLY DLRDG  LI LLEVLSG+ LP+  KGRMR
Sbjct: 37   DEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMR 96

Query: 230  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288
             H L+NV  AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V  +  
Sbjct: 97   IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDN 156

Query: 289  -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347
             E  +AK+ LLLW Q    GY  +   NFT+SWRDG  FNA+IH+H+P LID +K+ +  
Sbjct: 157  KEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSN 216

Query: 348  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406
               NL  AF++AE+ LG+T+LLDPED+ V  PDEKSIITYV + Y    ++  +  +G R
Sbjct: 217  AHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR 276

Query: 407  -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459
                   A E +   ++Y  L   LL+W+         R+F +S   ++     F  ++ 
Sbjct: 277  IGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRT 336

Query: 460  MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 516
            +E P K  +K   + +  +++  ++A   KV     G    D+ K W +L  A  ERE  
Sbjct: 337  VEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELA 396

Query: 517  LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573
            LR+E  R E L+++  +   +A + E  L +   L+  D     L A     ++   +E 
Sbjct: 397  LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIET 456

Query: 574  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRLKAGVA 630
            D+   +  ++ +    + L+   +   +++  R   V RL E L+ +      RL+  + 
Sbjct: 457  DIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLG 516

Query: 631  APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 690
                      LQ + +        + Y+ D   W++E +  V   ++G  L  VE  L  
Sbjct: 517  ----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLLQK 556

Query: 691  HRGLH-------QSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN---S 740
            H  +        + +    A  ++  +D     P      RD +  ++  Y +L      
Sbjct: 557  HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 616

Query: 741  SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 800
             +ARL     L  F     +E  W+ EKE+     D+    T++      + A   E+  
Sbjct: 617  RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 676

Query: 801  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 860
            +    ++    G+ ++ E+H     +      ++ QW+ + QL    +  L+E +   QF
Sbjct: 677  RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 736

Query: 861  FSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 920
             +D  + +     + + L+  +S D        + L++  +D  E++  Y+  L  L ++
Sbjct: 737  QADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 793

Query: 921  AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKGDECQL 963
            A A+ Q     P   +RGRL  +    YK+V E+T                  + D C+L
Sbjct: 794  ASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEADACEL 850

Query: 964  ------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEVQEAV------- 1002
                          P +    +V+       E  + +    V   NQ  ++ +       
Sbjct: 851  WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE 910

Query: 1003 TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTLKPEE- 1054
              ++AQ   L T W Q    VD K     S L+ Q+   +    +SW     + ++  + 
Sbjct: 911  KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 970

Query: 1055 -----------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1097
                               + L ++E       ++++      P+            S  
Sbjct: 971  LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1030

Query: 1098 YQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1154
            ++++   L++ E    E S+ Q+ + +L D +  L   +T              + +   
Sbjct: 1031 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------SEDMPN 1079

Query: 1155 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-LTLG-- 1205
             + E +K   + E +   +     + +K+  + E      T      LR  L+ L  G  
Sbjct: 1080 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWN 1139

Query: 1206 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1265
            +L ++       L +       +R T+ AE  L   E  L   + +P T   LE  +A++
Sbjct: 1140 ELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEGAEAAI 1195

Query: 1266 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1325
            KK     E    T DA  +++    E G RL     + ++  +R +E+V  + +R +   
Sbjct: 1196 KK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDRHRKNR 1248

Query: 1326 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1358
                     L+   R L+ + +    L  W+ +
Sbjct: 1249 ETASELLMRLKD-NRDLQKFLQDCQELSLWINE 1280



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 185/927 (19%), Positives = 344/927 (37%), Gaps = 109/927 (11%)

Query: 498  DVEKEWGKLHV-------AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQAD- 549
            D++KE  KL         AIL R  ++   +E ++   +       EA   ++ L   D 
Sbjct: 1001 DLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDD 1060

Query: 550  --ALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFN---DVQTLKD-GRHPQGEQM 603
              + L      +A+  +P    E E+ L + +++   + N   D Q ++D G      Q 
Sbjct: 1061 FQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQT 1120

Query: 604  YRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA 663
              +   L +RL A+ T +N   K               Q   R  +  ++ L   + +LA
Sbjct: 1121 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1180

Query: 664  WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS--DEGQLSPATRG 721
              E     ++GAE      +++ Q      +  + E+  A +E  R    +G ++     
Sbjct: 1181 HTEMPT-TLEGAE-----AAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQ 1234

Query: 722  AYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRN 781
               D +     +  +  +    RL+    L  F+    +  +W+NEK        + D  
Sbjct: 1235 EKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY-DEA 1293

Query: 782  TNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWML 841
             N+ +K   + A M EL   ++ + +++  G +L+ E       V+     L   W  +L
Sbjct: 1294 RNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE-VL 1352

Query: 842  QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK-NSCDRSATVTRLEDLLQDA 900
            +     +A    +A   + F+   ++   L K    L  +  S D    +T +  LL+  
Sbjct: 1353 ESTTQTKAQRLFDANKAELFT---QSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQ 1409

Query: 901  QDEKEQLNEYKGHLSGLAKRAKAV----------------VQLKPRHPAHPMRGRL-PLL 943
            Q  + Q+   K  +  L  +A+A+                VQ K      P+  R   LL
Sbjct: 1410 QMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLL 1469

Query: 944  AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVT 1003
            A  +  Q    V   DE   VG   P     L++S           L+   NQ +Q+ + 
Sbjct: 1470 ASKEIHQFNRDVE--DEILWVGERMP-----LATSTDHGHNLQTVQLLIKKNQTLQKEIQ 1522

Query: 1004 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 1063
              + +   +      +  D  SL A    +R   L + W L    T K   + +  H  +
Sbjct: 1523 GHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQ 1582

Query: 1064 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1123
             +Y     D+ +A  +  E                Q+L    E+ A++E   Q  +S LK
Sbjct: 1583 QYY----FDAAEAEAWMSE----------------QELYMMSEEKAKDE---QSAVSMLK 1619

Query: 1124 DIRLQLEACE--TRTVHRL-----RLPLDKEPARE-CAQRIAEQQKAQAEVEGLGKGVAR 1175
              ++  +A E    TVH+L      L  D  P  E  + R ++  K  A ++ L +    
Sbjct: 1620 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRG 1679

Query: 1176 LSAEAEKVLALPEPSPAAPTLRSELELTLGK------LEQVRSLSAIYLEKLKTISLVIR 1229
               E  ++  L           +E E+  G        E V  L   + E  +    +  
Sbjct: 1680 KLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI-- 1737

Query: 1230 GTQGAEEVLRAHEEQLKEAQAVPATLPEL-----EATKASLKKLRAQAEAQQPTFDALRD 1284
            G +  + V    +E +    +  AT+ E      EA    L+ +  + +    +++ L  
Sbjct: 1738 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYE-LHK 1796

Query: 1285 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1344
                A+E+  R+Q +H +   E+ R  +   + L+R           + +++ LG Q+R 
Sbjct: 1797 FYHDAKEIFGRIQDKHKKLPEELGR-DQNTVETLQRMHTTF------EHDIQALGTQVRQ 1849

Query: 1345 YRESADPL-----GAWLQDARRRQEQI 1366
             +E A  L     G    D ++R+ ++
Sbjct: 1850 LQEDAARLQAAYAGDKADDIQKRENEV 1876



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 89/451 (19%), Positives = 182/451 (40%), Gaps = 58/451 (12%)

Query: 498  DVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALL----Q 553
            D+++ WG L   I E EK+ R   E     Q      + EA + E++L+          Q
Sbjct: 1556 DLKQLWGLL---IEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQ 1612

Query: 554  SDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER 613
            S + +L   ++ ++A E     D A+++ +L       + D  HP+ E++  R  ++   
Sbjct: 1613 SAVSMLKKHQILEQAVE-----DYAETVHQLSKTSRALVADS-HPESERISMRQSKVD-- 1664

Query: 614  LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED-----STLRYLQDLLAWVEEN 668
                      +L AG+   A +          RR +L++        R + DL  W+ E 
Sbjct: 1665 ----------KLYAGLKDLAEE----------RRGKLDERHRLFQLNREVDDLEQWIAER 1704

Query: 669  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-QAKIERAR--SDE----GQLSPATRG 721
            +      E G D   V       R   +      Q +++     +DE    G    AT  
Sbjct: 1705 EVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIA 1764

Query: 722  AYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE---EEVGFDWS 778
             ++D L        +L+++    L +   LH F   A +    + +K +   EE+G    
Sbjct: 1765 EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELG---R 1821

Query: 779  DRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPT-VESFQAALQTQW 837
            D+NT  T ++  ++    +++    ++++LQ    RL       +   ++  +  +   W
Sbjct: 1822 DQNTVETLQR-MHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAW 1880

Query: 838  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLL 897
              +L  C      L +    F+FFS VR+    +  +++ +R+  + ++   V+ +E L+
Sbjct: 1881 KSLLDACESRRVRLVDTGDKFRFFSMVRDL---MLWMEDVIRQIEAQEKPRDVSSVELLM 1937

Query: 898  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
             + Q  K +++      +   +  K+++  K
Sbjct: 1938 NNHQGIKAEIDARNDSFTTCIELGKSLLARK 1968



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 151/753 (20%), Positives = 279/753 (37%), Gaps = 105/753 (13%)

Query: 131  EEQRLYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKTSTKWVN---- 186
            E Q   R+KE+EE+  +         + L++ G     +TDE D  +    TK++     
Sbjct: 1413 ENQMEVRKKEIEELQSQA--------QALSQEGK----STDEVDSKRLTVQTKFMELLEP 1460

Query: 187  ----KHLIKAQRHISDLYEDLRDGHNLISLLEVL-SGDSLPREKGRMRFHKLQNVQIAL- 240
                KH + A + I     D+ D        E+L  G+ +P        H LQ VQ+ + 
Sbjct: 1461 LNERKHNLLASKEIHQFNRDVED--------EILWVGERMPLATSTDHGHNLQTVQLLIK 1512

Query: 241  -DYLRHRQVKLVNIRNDDIADGNPKLTL--GLIWTIILHFQISDI-QVSGQSEDMTAKEK 296
             +    ++++    R DDI + +  +      +    +  +++D+ Q+ G   + T K  
Sbjct: 1513 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1572

Query: 297  LLLWSQRMVEGYQGLRCDNFTSSWR-DGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQA 355
              L      + Y     +    +W  +  L+     + K     ++ + +   LE   + 
Sbjct: 1573 RRLEEAHRAQQYYFDAAE--AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVED 1630

Query: 356  FSVAERDLGVT-RLL----DPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
            ++     L  T R L     PE   +     K     V  LY  +  + + + G + +E 
Sbjct: 1631 YAETVHQLSKTSRALVADSHPESERISMRQSK-----VDKLYAGLKDLAEERRG-KLDER 1684

Query: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
               +Q  RE V  L QW+               +E + +L  +F +F             
Sbjct: 1685 HRLFQLNRE-VDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFA------------ 1731

Query: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
            R  G           GQ +V    H  D     G    A +   K   +E    + L+ I
Sbjct: 1732 RDTG---------NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNE-AWADLLELI 1781

Query: 531  VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
             T+ Q+ A   E      DA            K+P+  G  +  ++    M     +D+Q
Sbjct: 1782 DTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQ 1841

Query: 591  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 650
             L      Q  Q+     RL       + + +++ +      A +      +S  RR  L
Sbjct: 1842 ALGT----QVRQLQEDAARLQAAYAGDKAD-DIQKRENEVLEAWKSLLDACES--RRVRL 1894

Query: 651  EDSTLRY-----LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI----EEF 701
             D+  ++     ++DL+ W+E+   +++  E   D+ SVE  + +H+G+   I    + F
Sbjct: 1895 VDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSF 1954

Query: 702  QAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAA 758
               IE  +S   +   A+    ++ L +L  +  ++++  + R   LR +  +H F   A
Sbjct: 1955 TTCIELGKSLLARKHYASE-EIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDA 2013

Query: 759  TKELMWLNEKE----EEEVGFDWSD----------RNTNMTAKKESYSALMRELELKEKK 804
            +    WL  +E      E+G    +             +     E +SAL R   L+  +
Sbjct: 2014 SVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLE 2073

Query: 805  IKELQNAGDRLLREDHPARPTVESFQAALQTQW 837
            ++  Q   +R  R   P   T  S +A  Q QW
Sbjct: 2074 VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQW 2106


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score =  338 bits (868), Expect = 2e-92
 Identities = 329/1293 (25%), Positives = 558/1293 (43%), Gaps = 154/1293 (11%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229
            DER+ VQKKT TKWVN HL +    I+DLY DLRDG  LI LLEVLSG+ LP+  KGRMR
Sbjct: 50   DEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMR 109

Query: 230  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288
             H L+NV  AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V  +  
Sbjct: 110  IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDN 169

Query: 289  -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347
             E  +AK+ LLLW Q    GY  +   NFT+SWRDG  FNA+IH+H+P LID +K+ +  
Sbjct: 170  KEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSN 229

Query: 348  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406
               NL  AF++AE+ LG+T+LLDPED+ V  PDEKSIITYV + Y    ++  +  +G R
Sbjct: 230  AHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR 289

Query: 407  -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459
                   A E +   ++Y  L   LL+W+         R+F +S   ++     F  ++ 
Sbjct: 290  IGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRT 349

Query: 460  MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 516
            +E P K  +K   + +  +++  ++A   KV     G    D+ K W +L  A  ERE  
Sbjct: 350  VEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELA 409

Query: 517  LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573
            LR+E  R E L+++  +   +A + E  L +   L+  D     L A     ++   +E 
Sbjct: 410  LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIET 469

Query: 574  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRLKAGVA 630
            D+   +  ++ +    + L+   +   +++  R   V RL E L+ +      RL+  + 
Sbjct: 470  DIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLG 529

Query: 631  APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 690
                      LQ + +        + Y+ D   W++E +  V   ++G  L  VE  L  
Sbjct: 530  ----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLLQK 569

Query: 691  HRGLH-------QSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN---S 740
            H  +        + +    A  ++  +D     P      RD +  ++  Y +L      
Sbjct: 570  HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629

Query: 741  SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 800
             +ARL     L  F     +E  W+ EKE+     D+    T++      + A   E+  
Sbjct: 630  RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 689

Query: 801  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 860
            +    ++    G+ ++ E+H     +      ++ QW+ + QL    +  L+E +   QF
Sbjct: 690  RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 749

Query: 861  FSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 920
             +D  + +     + + L+  +S D        + L++  +D  E++  Y+  L  L ++
Sbjct: 750  QADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 806

Query: 921  AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKGDECQL 963
            A A+ Q     P   +RGRL  +    YK+V E+T                  + D C+L
Sbjct: 807  ASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEADACEL 863

Query: 964  ------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEVQEAV------- 1002
                          P +    +V+       E  + +    V   NQ  ++ +       
Sbjct: 864  WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE 923

Query: 1003 TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTLKPEE- 1054
              ++AQ   L T W Q    VD K     S L+ Q+   +    +SW     + ++  + 
Sbjct: 924  KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983

Query: 1055 -----------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1097
                               + L ++E       ++++      P+            S  
Sbjct: 984  LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043

Query: 1098 YQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1154
            ++++   L++ E    E S+ Q+ + +L D +  L   +T              + +   
Sbjct: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------SEDMPN 1092

Query: 1155 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-LTLG-- 1205
             + E +K   + E +   +     + +K+  + E      T      LR  L+ L  G  
Sbjct: 1093 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWN 1152

Query: 1206 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1265
            +L ++       L +       +R T+ AE  L   E  L   + +P T   LE  +A++
Sbjct: 1153 ELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEGAEAAI 1208

Query: 1266 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1325
            KK     E    T DA  +++    E G RL     + ++  +R +E+V  + +R +   
Sbjct: 1209 KK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDRHRKNR 1261

Query: 1326 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1358
                     L+   R L+ + +    L  W+ +
Sbjct: 1262 ETASELLMRLKD-NRDLQKFLQDCQELSLWINE 1293



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 185/927 (19%), Positives = 344/927 (37%), Gaps = 109/927 (11%)

Query: 498  DVEKEWGKLHV-------AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQAD- 549
            D++KE  KL         AIL R  ++   +E ++   +       EA   ++ L   D 
Sbjct: 1014 DLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDD 1073

Query: 550  --ALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFN---DVQTLKD-GRHPQGEQM 603
              + L      +A+  +P    E E+ L + +++   + N   D Q ++D G      Q 
Sbjct: 1074 FQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQT 1133

Query: 604  YRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA 663
              +   L +RL A+ T +N   K               Q   R  +  ++ L   + +LA
Sbjct: 1134 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1193

Query: 664  WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS--DEGQLSPATRG 721
              E     ++GAE      +++ Q      +  + E+  A +E  R    +G ++     
Sbjct: 1194 HTEMPT-TLEGAE-----AAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQ 1247

Query: 722  AYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRN 781
               D +     +  +  +    RL+    L  F+    +  +W+NEK        + D  
Sbjct: 1248 EKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY-DEA 1306

Query: 782  TNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWML 841
             N+ +K   + A M EL   ++ + +++  G +L+ E       V+     L   W  +L
Sbjct: 1307 RNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE-VL 1365

Query: 842  QLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK-NSCDRSATVTRLEDLLQDA 900
            +     +A    +A   + F+   ++   L K    L  +  S D    +T +  LL+  
Sbjct: 1366 ESTTQTKAQRLFDANKAELFT---QSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQ 1422

Query: 901  QDEKEQLNEYKGHLSGLAKRAKAV----------------VQLKPRHPAHPMRGRL-PLL 943
            Q  + Q+   K  +  L  +A+A+                VQ K      P+  R   LL
Sbjct: 1423 QMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLL 1482

Query: 944  AVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVT 1003
            A  +  Q    V   DE   VG   P     L++S           L+   NQ +Q+ + 
Sbjct: 1483 ASKEIHQFNRDVE--DEILWVGERMP-----LATSTDHGHNLQTVQLLIKKNQTLQKEIQ 1535

Query: 1004 RLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLE 1063
              + +   +      +  D  SL A    +R   L + W L    T K   + +  H  +
Sbjct: 1536 GHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQ 1595

Query: 1064 LHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK 1123
             +Y     D+ +A  +  E                Q+L    E+ A++E   Q  +S LK
Sbjct: 1596 QYY----FDAAEAEAWMSE----------------QELYMMSEEKAKDE---QSAVSMLK 1632

Query: 1124 DIRLQLEACE--TRTVHRL-----RLPLDKEPARE-CAQRIAEQQKAQAEVEGLGKGVAR 1175
              ++  +A E    TVH+L      L  D  P  E  + R ++  K  A ++ L +    
Sbjct: 1633 KHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRG 1692

Query: 1176 LSAEAEKVLALPEPSPAAPTLRSELELTLGK------LEQVRSLSAIYLEKLKTISLVIR 1229
               E  ++  L           +E E+  G        E V  L   + E  +    +  
Sbjct: 1693 KLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNI-- 1750

Query: 1230 GTQGAEEVLRAHEEQLKEAQAVPATLPEL-----EATKASLKKLRAQAEAQQPTFDALRD 1284
            G +  + V    +E +    +  AT+ E      EA    L+ +  + +    +++ L  
Sbjct: 1751 GQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYE-LHK 1809

Query: 1285 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1344
                A+E+  R+Q +H +   E+ R  +   + L+R           + +++ LG Q+R 
Sbjct: 1810 FYHDAKEIFGRIQDKHKKLPEELGR-DQNTVETLQRMHTTF------EHDIQALGTQVRQ 1862

Query: 1345 YRESADPL-----GAWLQDARRRQEQI 1366
             +E A  L     G    D ++R+ ++
Sbjct: 1863 LQEDAARLQAAYAGDKADDIQKRENEV 1889



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 89/451 (19%), Positives = 182/451 (40%), Gaps = 58/451 (12%)

Query: 498  DVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALL----Q 553
            D+++ WG L   I E EK+ R   E     Q      + EA + E++L+          Q
Sbjct: 1569 DLKQLWGLL---IEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQ 1625

Query: 554  SDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER 613
            S + +L   ++ ++A E     D A+++ +L       + D  HP+ E++  R  ++   
Sbjct: 1626 SAVSMLKKHQILEQAVE-----DYAETVHQLSKTSRALVADS-HPESERISMRQSKVD-- 1677

Query: 614  LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELED-----STLRYLQDLLAWVEEN 668
                      +L AG+   A +          RR +L++        R + DL  W+ E 
Sbjct: 1678 ----------KLYAGLKDLAEE----------RRGKLDERHRLFQLNREVDDLEQWIAER 1717

Query: 669  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-QAKIERAR--SDE----GQLSPATRG 721
            +      E G D   V       R   +      Q +++     +DE    G    AT  
Sbjct: 1718 EVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIA 1777

Query: 722  AYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE---EEVGFDWS 778
             ++D L        +L+++    L +   LH F   A +    + +K +   EE+G    
Sbjct: 1778 EWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELG---R 1834

Query: 779  DRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPT-VESFQAALQTQW 837
            D+NT  T ++  ++    +++    ++++LQ    RL       +   ++  +  +   W
Sbjct: 1835 DQNTVETLQR-MHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAW 1893

Query: 838  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLL 897
              +L  C      L +    F+FFS VR+    +  +++ +R+  + ++   V+ +E L+
Sbjct: 1894 KSLLDACESRRVRLVDTGDKFRFFSMVRDL---MLWMEDVIRQIEAQEKPRDVSSVELLM 1950

Query: 898  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928
             + Q  K +++      +   +  K+++  K
Sbjct: 1951 NNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 151/753 (20%), Positives = 279/753 (37%), Gaps = 105/753 (13%)

Query: 131  EEQRLYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKTSTKWVN---- 186
            E Q   R+KE+EE+  +         + L++ G     +TDE D  +    TK++     
Sbjct: 1426 ENQMEVRKKEIEELQSQA--------QALSQEGK----STDEVDSKRLTVQTKFMELLEP 1473

Query: 187  ----KHLIKAQRHISDLYEDLRDGHNLISLLEVL-SGDSLPREKGRMRFHKLQNVQIAL- 240
                KH + A + I     D+ D        E+L  G+ +P        H LQ VQ+ + 
Sbjct: 1474 LNERKHNLLASKEIHQFNRDVED--------EILWVGERMPLATSTDHGHNLQTVQLLIK 1525

Query: 241  -DYLRHRQVKLVNIRNDDIADGNPKLTL--GLIWTIILHFQISDI-QVSGQSEDMTAKEK 296
             +    ++++    R DDI + +  +      +    +  +++D+ Q+ G   + T K  
Sbjct: 1526 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1585

Query: 297  LLLWSQRMVEGYQGLRCDNFTSSWR-DGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQA 355
              L      + Y     +    +W  +  L+     + K     ++ + +   LE   + 
Sbjct: 1586 RRLEEAHRAQQYYFDAAE--AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVED 1643

Query: 356  FSVAERDLGVT-RLL----DPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410
            ++     L  T R L     PE   +     K     V  LY  +  + + + G + +E 
Sbjct: 1644 YAETVHQLSKTSRALVADSHPESERISMRQSK-----VDKLYAGLKDLAEERRG-KLDER 1697

Query: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
               +Q  RE V  L QW+               +E + +L  +F +F             
Sbjct: 1698 HRLFQLNRE-VDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFA------------ 1744

Query: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530
            R  G           GQ +V    H  D     G    A +   K   +E    + L+ I
Sbjct: 1745 RDTG---------NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNE-AWADLLELI 1794

Query: 531  VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590
             T+ Q+ A   E      DA            K+P+  G  +  ++    M     +D+Q
Sbjct: 1795 DTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQ 1854

Query: 591  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 650
             L      Q  Q+     RL       + + +++ +      A +      +S  RR  L
Sbjct: 1855 ALGT----QVRQLQEDAARLQAAYAGDKAD-DIQKRENEVLEAWKSLLDACES--RRVRL 1907

Query: 651  EDSTLRY-----LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI----EEF 701
             D+  ++     ++DL+ W+E+   +++  E   D+ SVE  + +H+G+   I    + F
Sbjct: 1908 VDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSF 1967

Query: 702  QAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAA 758
               IE  +S   +   A+    ++ L +L  +  ++++  + R   LR +  +H F   A
Sbjct: 1968 TTCIELGKSLLARKHYASE-EIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDA 2026

Query: 759  TKELMWLNEKE----EEEVGFDWSD----------RNTNMTAKKESYSALMRELELKEKK 804
            +    WL  +E      E+G    +             +     E +SAL R   L+  +
Sbjct: 2027 SVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLE 2086

Query: 805  IKELQNAGDRLLREDHPARPTVESFQAALQTQW 837
            ++  Q   +R  R   P   T  S +A  Q QW
Sbjct: 2087 VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQW 2119


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score =  337 bits (865), Expect = 4e-92
 Identities = 348/1301 (26%), Positives = 564/1301 (43%), Gaps = 171/1301 (13%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229
            DER+ VQKKT TKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP+  KG+MR
Sbjct: 50   DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109

Query: 230  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288
             H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V  Q  
Sbjct: 110  IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169

Query: 289  -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347
             E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID +K+    
Sbjct: 170  RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229

Query: 348  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406
               NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++  +  +G R
Sbjct: 230  ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289

Query: 407  -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459
                   A E +   ++Y  L   LL W+         R+F +S   ++     F  ++ 
Sbjct: 290  VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349

Query: 460  MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 516
            +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  A   RE  
Sbjct: 350  VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409

Query: 517  LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573
            LR+E  R E L+++  +   +A + E  L +   L+  D     L A     ++   +E 
Sbjct: 410  LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469

Query: 574  DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 632
            D    +  +R L +  Q L K+  H Q             + +  R +  LRL       
Sbjct: 470  DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509

Query: 633  ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 689
                 Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L  VE  L 
Sbjct: 510  -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568

Query: 690  SHRGLHQSIEEFQAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 741
             H+ +   I     K++       +  EG+   P      +D +  L+  + +L N +  
Sbjct: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628

Query: 742  -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 800
             KA+L   + L  F     +   W+ EKE+     D+    T++   +  + A   EL  
Sbjct: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688

Query: 801  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 860
             +  ++++      ++       P +E+    +  QW  +  L    + +L++   +FQF
Sbjct: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748

Query: 861  FSDVREAEGQLQKLQEALRRKN-SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 919
              D  + +  LQ     L  ++   D  AT      L +  +D  E+L E +G +  L +
Sbjct: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804

Query: 920  RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 964
            +A+   +     P   H ++    L    +A  D +Q        +     + D C+L +
Sbjct: 805  QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864

Query: 965  GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 997
            G  +                             K L +   G   A  S+     P ++E
Sbjct: 865  GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924

Query: 998  VQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 1033
            V++    L  + QA  TL              H   VD +    W           + L 
Sbjct: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984

Query: 1034 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 1093
            RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE +     + G 
Sbjct: 985  RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034

Query: 1094 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1146
               H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V    +P   
Sbjct: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090

Query: 1147 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1201
            E   E  Q + +    + E++G      R+    EKV+   +  P    L   LE     
Sbjct: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149

Query: 1202 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1260
               LG++ + RS +   L +        +  + AE +L   E  L   +   +    LEA
Sbjct: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202

Query: 1261 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1320
             +A ++K     E    + +  RD++    + G +L     E ++  ++ +E+V  + +R
Sbjct: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255

Query: 1321 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQD 1358
             +    + + + +E   L R   +L+ + ++   L  W+ D
Sbjct: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWIND 1292



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 88/440 (20%), Positives = 175/440 (39%), Gaps = 42/440 (9%)

Query: 499  VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRL 558
            ++  W +L  A   R ++LR   +  E  Q  +   + EA + E++L+     +  D   
Sbjct: 1562 LQSSWDRLREAAAGRLQRLR---DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEE- 1617

Query: 559  LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 618
              A  + +R    +R ++     I+ L +  Q L    HP+GEQ+ R   ++ +    ++
Sbjct: 1618 -GAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLK 1676

Query: 619  TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWG 678
                 R +              L+++    +L+  T     DL  W+ E +      E G
Sbjct: 1677 DVAEERKRK-------------LENMYHLFQLKRET----DDLEQWISEKELVASSPEMG 1719

Query: 679  VDLPSVEAQLGSHRGL--------HQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRL 730
             D   V       R           + ++   A IER   D G    AT   ++D L  +
Sbjct: 1720 QDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERL-IDAGHSEAATIAEWKDGLNEM 1778

Query: 731  DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE---EEVGFDWSDRNTNMTAK 787
                 +L+++    L +   LH +     + L  ++EK     E+VG D S       + 
Sbjct: 1779 WADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDAS----TAESF 1834

Query: 788  KESYSALMRELELKEKKIKELQNAGDRLLREDHPAR-PTVESFQAALQTQWSWMLQLCCC 846
               ++A  REL L   ++++ Q+   RL       +   +++ +  +   W  +L  C  
Sbjct: 1835 HRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAG 1894

Query: 847  IEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQ 906
                L + A  F+FFS  R+    L  ++  +R+  + +R   V+ +E L++  Q    +
Sbjct: 1895 RRTQLVDTADKFRFFSMARDL---LSWMESIIRQIETQERPRDVSSVELLMKYHQGINAE 1951

Query: 907  LNEYKGHLSGLAKRAKAVVQ 926
            +     + S   +  ++++Q
Sbjct: 1952 IETRSKNFSACLELGESLLQ 1971



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 196/982 (19%), Positives = 359/982 (36%), Gaps = 180/982 (18%)

Query: 495  HPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADAL--- 551
            H +   K++G  H  I  R K++ +++++L+ L     K   +A    +    AD L   
Sbjct: 701  HGMVARKQFG--HPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAW 758

Query: 552  LQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGE---QMYRRVY 608
            LQ   RLL+   V Q  G   R L K          + + + +    Q +   + +R   
Sbjct: 759  LQDAHRLLSGEDVGQDEGAT-RALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSP 817

Query: 609  RLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA-WVEE 667
             +  RL A+R  Y              VAQ  L+  + +  L+  T+    D    W+ E
Sbjct: 818  DVTHRLQALRELYQ-----------QVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866

Query: 668  NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQL----SPATRGA- 722
             +  +   E    L  +E        L Q ++    +I+        L     P +R   
Sbjct: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926

Query: 723  -YRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE-EVGFDWSDR 780
             Y+D L      +  L++  +  + S   +H++     +   W+ +K +  E   D    
Sbjct: 927  QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986

Query: 781  NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 840
               + A +   S L R++   + ++  L+    +L+      +  +   Q  L+  W  +
Sbjct: 987  LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046

Query: 841  LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDA 900
             Q     E  L E +    F  D+ + +  L   Q+A+  +   D   ++   E LLQ  
Sbjct: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASE---DMPESLPEAEQLLQQH 1103

Query: 901  QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRG-------------------RLP 941
               K++++ ++     + +  + V+Q +   P + + G                   R  
Sbjct: 1104 AGIKDEIDGHQDSYQRVKESGEKVIQGQT-DPEYLLLGQRLEGLDTGWNALGRMWESRSH 1162

Query: 942  LLAVC--------DYKQVEVTVHKGDEC---------------------QLVGPAQPSHW 972
             LA C        D KQ E  +   +                         +G  + +  
Sbjct: 1163 TLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRD 1222

Query: 973  KVLS--SSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQ 1030
            KVLS   SG++       +     + +++E V  +E +H+       +  V ++  L  Q
Sbjct: 1223 KVLSPVDSGNKLVAEGNLY-----SDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ 1277

Query: 1031 SLRRDVQLIRSW---SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGF-----GPE 1082
            +  ++ Q +  W    L T + +  +E R  LH+  L +QAF+ +     G+        
Sbjct: 1278 NFLQNCQELTLWINDKLLTSQDVSYDEARN-LHNKWLKHQAFVAELASHEGWLENIDAEG 1336

Query: 1083 DRLMAEREYGSCSHHYQQLLQSLE------QGAQEESRCQRCISELKDIRLQLEACETRT 1136
             +LM E+   +      Q L++L       Q   +E       +   D+RLQ  A   + 
Sbjct: 1337 KQLMDEKPQFTAL--VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394

Query: 1137 VHRLRLPL-DKEPARECA---------QRIAEQQKAQ--------AEVEGLGK--GVARL 1176
            +  +   L   +P ++           +R+ +Q   +        A+V  +G+  G A L
Sbjct: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454

Query: 1177 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL---------------SAIYLEKL 1221
            S E ++ L L EP       + +LE +  KL+  R L               SA Y   L
Sbjct: 1455 SIE-KRFLDLLEPLGRR---KKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNL 1510

Query: 1222 KTISLVIRGTQGAEEVLRAHE----------EQLKEA-----QAVPATLPEL-------- 1258
            +T+ L ++  Q  +  +  H           +QL EA     Q +   L  L        
Sbjct: 1511 QTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLR 1570

Query: 1259 EATKASLKKLRAQAEAQQPTFDA--------------LRDELRGAQEVGERLQQRHGERD 1304
            EA    L++LR   EAQQ   DA              + DE+   +E    + +RH  + 
Sbjct: 1571 EAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQ 1630

Query: 1305 VEVERWRERVAQLLERWQAVLA 1326
              VE +   + QL  R Q +L+
Sbjct: 1631 RAVEDYGRNIKQLASRAQGLLS 1652



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 72/370 (19%), Positives = 144/370 (38%), Gaps = 28/370 (7%)

Query: 522  ERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRL---------LAAGKVPQRAGEVE 572
            ++LE L R+  +LQ      +E+     A   SD+RL         ++A +   R+ +  
Sbjct: 1352 QKLEALHRLWDELQATT---KEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPG 1408

Query: 573  RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 632
            +DL   + M+  L   V+   + R  +  +++ +V  + E       + +L ++      
Sbjct: 1409 KDLTSVNRMLAKL-KRVEDQVNVRKEELGELFAQVPSMGEE----GGDADLSIEKRFLDL 1463

Query: 633  ATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 692
               + +   Q    R +L+ S  R L+D   WVEE       A++G +L +V+  +  ++
Sbjct: 1464 LEPLGRRKKQLESSRAKLQIS--RDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQ 1521

Query: 693  GLHQSIEEFQAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKARLRSLE 749
             L   I     ++E       QL  A     +D    LG L   + +L  ++  RL+ L 
Sbjct: 1522 TLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLR 1581

Query: 750  SLH---SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 806
              +    +   A +   W+ E+E   +  +            + +    R +E   + IK
Sbjct: 1582 DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIK 1641

Query: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
            +L +    LL   HP    +   Q  +   ++ +  +    E   ++    +  F   RE
Sbjct: 1642 QLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVA---EERKRKLENMYHLFQLKRE 1698

Query: 867  AEGQLQKLQE 876
             +   Q + E
Sbjct: 1699 TDDLEQWISE 1708



 Score = 35.0 bits (79), Expect = 0.49
 Identities = 46/190 (24%), Positives = 78/190 (41%), Gaps = 29/190 (15%)

Query: 646  RRPELEDSTLRY-----LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE- 699
            RR +L D+  ++      +DLL+W+E    +++  E   D+ SVE  +  H+G++  IE 
Sbjct: 1895 RRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIET 1954

Query: 700  ---EFQAKIERARS---DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753
                F A +E   S    + Q S   R   +  + R      K   +   RLR L  +  
Sbjct: 1955 RSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEK-WEARWERLRMLLEVCQ 2013

Query: 754  FVAAATKELMWLNEKEEEEVGFDWS----------------DRNTNMTAKKESYSALMRE 797
            F   A+    WL  +E      D+                 +++T   A++ +       
Sbjct: 2014 FSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTT 2073

Query: 798  LELKEKKIKE 807
            LELKE++I E
Sbjct: 2074 LELKERQIAE 2083


>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score =  337 bits (865), Expect = 4e-92
 Identities = 348/1301 (26%), Positives = 564/1301 (43%), Gaps = 171/1301 (13%)

Query: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229
            DER+ VQKKT TKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP+  KG+MR
Sbjct: 50   DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109

Query: 230  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288
             H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V  Q  
Sbjct: 110  IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169

Query: 289  -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347
             E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID +K+    
Sbjct: 170  RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229

Query: 348  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406
               NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++  +  +G R
Sbjct: 230  ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289

Query: 407  -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459
                   A E +   ++Y  L   LL W+         R+F +S   ++     F  ++ 
Sbjct: 290  VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349

Query: 460  MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 516
            +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  A   RE  
Sbjct: 350  VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409

Query: 517  LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573
            LR+E  R E L+++  +   +A + E  L +   L+  D     L A     ++   +E 
Sbjct: 410  LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469

Query: 574  DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 632
            D    +  +R L +  Q L K+  H Q             + +  R +  LRL       
Sbjct: 470  DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509

Query: 633  ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 689
                 Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L  VE  L 
Sbjct: 510  -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568

Query: 690  SHRGLHQSIEEFQAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 741
             H+ +   I     K++       +  EG+   P      +D +  L+  + +L N +  
Sbjct: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628

Query: 742  -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 800
             KA+L   + L  F     +   W+ EKE+     D+    T++   +  + A   EL  
Sbjct: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688

Query: 801  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 860
             +  ++++      ++       P +E+    +  QW  +  L    + +L++   +FQF
Sbjct: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748

Query: 861  FSDVREAEGQLQKLQEALRRKN-SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 919
              D  + +  LQ     L  ++   D  AT      L +  +D  E+L E +G +  L +
Sbjct: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804

Query: 920  RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 964
            +A+   +     P   H ++    L    +A  D +Q        +     + D C+L +
Sbjct: 805  QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864

Query: 965  GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 997
            G  +                             K L +   G   A  S+     P ++E
Sbjct: 865  GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924

Query: 998  VQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 1033
            V++    L  + QA  TL              H   VD +    W           + L 
Sbjct: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984

Query: 1034 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 1093
            RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE +     + G 
Sbjct: 985  RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034

Query: 1094 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1146
               H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V    +P   
Sbjct: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090

Query: 1147 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1201
            E   E  Q + +    + E++G      R+    EKV+   +  P    L   LE     
Sbjct: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149

Query: 1202 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1260
               LG++ + RS +   L +        +  + AE +L   E  L   +   +    LEA
Sbjct: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202

Query: 1261 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1320
             +A ++K     E    + +  RD++    + G +L     E ++  ++ +E+V  + +R
Sbjct: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255

Query: 1321 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQD 1358
             +    + + + +E   L R   +L+ + ++   L  W+ D
Sbjct: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWIND 1292



 Score = 64.3 bits (155), Expect = 8e-10
 Identities = 88/440 (20%), Positives = 175/440 (39%), Gaps = 42/440 (9%)

Query: 499  VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRL 558
            ++  W +L  A   R ++LR   +  E  Q  +   + EA + E++L+     +  D   
Sbjct: 1562 LQSSWDRLREAAAGRLQRLR---DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEE- 1617

Query: 559  LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 618
              A  + +R    +R ++     I+ L +  Q L    HP+GEQ+ R   ++ +    ++
Sbjct: 1618 -GAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLK 1676

Query: 619  TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWG 678
                 R +              L+++    +L+  T     DL  W+ E +      E G
Sbjct: 1677 DVAEERKRK-------------LENMYHLFQLKRET----DDLEQWISEKELVASSPEMG 1719

Query: 679  VDLPSVEAQLGSHRGL--------HQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRL 730
             D   V       R           + ++   A IER   D G    AT   ++D L  +
Sbjct: 1720 QDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERL-IDAGHSEAATIAEWKDGLNEM 1778

Query: 731  DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE---EEVGFDWSDRNTNMTAK 787
                 +L+++    L +   LH +     + L  ++EK     E+VG D S       + 
Sbjct: 1779 WADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDAS----TAESF 1834

Query: 788  KESYSALMRELELKEKKIKELQNAGDRLLREDHPAR-PTVESFQAALQTQWSWMLQLCCC 846
               ++A  REL L   ++++ Q+   RL       +   +++ +  +   W  +L  C  
Sbjct: 1835 HRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAG 1894

Query: 847  IEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQ 906
                L + A  F+FFS  R+    L  ++  +R+  + +R   V+ +E L++  Q    +
Sbjct: 1895 RRTQLVDTADKFRFFSMARDL---LSWMESIIRQIETQERPRDVSSVELLMKYHQGINAE 1951

Query: 907  LNEYKGHLSGLAKRAKAVVQ 926
            +     + S   +  ++++Q
Sbjct: 1952 IETRSKNFSACLELGESLLQ 1971



 Score = 49.3 bits (116), Expect = 3e-05
 Identities = 196/982 (19%), Positives = 359/982 (36%), Gaps = 180/982 (18%)

Query: 495  HPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADAL--- 551
            H +   K++G  H  I  R K++ +++++L+ L     K   +A    +    AD L   
Sbjct: 701  HGMVARKQFG--HPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAW 758

Query: 552  LQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGE---QMYRRVY 608
            LQ   RLL+   V Q  G   R L K          + + + +    Q +   + +R   
Sbjct: 759  LQDAHRLLSGEDVGQDEGAT-RALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSP 817

Query: 609  RLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA-WVEE 667
             +  RL A+R  Y              VAQ  L+  + +  L+  T+    D    W+ E
Sbjct: 818  DVTHRLQALRELYQ-----------QVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866

Query: 668  NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQL----SPATRGA- 722
             +  +   E    L  +E        L Q ++    +I+        L     P +R   
Sbjct: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926

Query: 723  -YRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE-EVGFDWSDR 780
             Y+D L      +  L++  +  + S   +H++     +   W+ +K +  E   D    
Sbjct: 927  QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986

Query: 781  NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 840
               + A +   S L R++   + ++  L+    +L+      +  +   Q  L+  W  +
Sbjct: 987  LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046

Query: 841  LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDA 900
             Q     E  L E +    F  D+ + +  L   Q+A+  +   D   ++   E LLQ  
Sbjct: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASE---DMPESLPEAEQLLQQH 1103

Query: 901  QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRG-------------------RLP 941
               K++++ ++     + +  + V+Q +   P + + G                   R  
Sbjct: 1104 AGIKDEIDGHQDSYQRVKESGEKVIQGQT-DPEYLLLGQRLEGLDTGWNALGRMWESRSH 1162

Query: 942  LLAVC--------DYKQVEVTVHKGDEC---------------------QLVGPAQPSHW 972
             LA C        D KQ E  +   +                         +G  + +  
Sbjct: 1163 TLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRD 1222

Query: 973  KVLS--SSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQ 1030
            KVLS   SG++       +     + +++E V  +E +H+       +  V ++  L  Q
Sbjct: 1223 KVLSPVDSGNKLVAEGNLY-----SDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ 1277

Query: 1031 SLRRDVQLIRSW---SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGF-----GPE 1082
            +  ++ Q +  W    L T + +  +E R  LH+  L +QAF+ +     G+        
Sbjct: 1278 NFLQNCQELTLWINDKLLTSQDVSYDEARN-LHNKWLKHQAFVAELASHEGWLENIDAEG 1336

Query: 1083 DRLMAEREYGSCSHHYQQLLQSLE------QGAQEESRCQRCISELKDIRLQLEACETRT 1136
             +LM E+   +      Q L++L       Q   +E       +   D+RLQ  A   + 
Sbjct: 1337 KQLMDEKPQFTAL--VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394

Query: 1137 VHRLRLPL-DKEPARECA---------QRIAEQQKAQ--------AEVEGLGK--GVARL 1176
            +  +   L   +P ++           +R+ +Q   +        A+V  +G+  G A L
Sbjct: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454

Query: 1177 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL---------------SAIYLEKL 1221
            S E ++ L L EP       + +LE +  KL+  R L               SA Y   L
Sbjct: 1455 SIE-KRFLDLLEPLGRR---KKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNL 1510

Query: 1222 KTISLVIRGTQGAEEVLRAHE----------EQLKEA-----QAVPATLPEL-------- 1258
            +T+ L ++  Q  +  +  H           +QL EA     Q +   L  L        
Sbjct: 1511 QTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLR 1570

Query: 1259 EATKASLKKLRAQAEAQQPTFDA--------------LRDELRGAQEVGERLQQRHGERD 1304
            EA    L++LR   EAQQ   DA              + DE+   +E    + +RH  + 
Sbjct: 1571 EAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQ 1630

Query: 1305 VEVERWRERVAQLLERWQAVLA 1326
              VE +   + QL  R Q +L+
Sbjct: 1631 RAVEDYGRNIKQLASRAQGLLS 1652



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 72/370 (19%), Positives = 144/370 (38%), Gaps = 28/370 (7%)

Query: 522  ERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRL---------LAAGKVPQRAGEVE 572
            ++LE L R+  +LQ      +E+     A   SD+RL         ++A +   R+ +  
Sbjct: 1352 QKLEALHRLWDELQATT---KEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPG 1408

Query: 573  RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 632
            +DL   + M+  L   V+   + R  +  +++ +V  + E       + +L ++      
Sbjct: 1409 KDLTSVNRMLAKL-KRVEDQVNVRKEELGELFAQVPSMGEE----GGDADLSIEKRFLDL 1463

Query: 633  ATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 692
               + +   Q    R +L+ S  R L+D   WVEE       A++G +L +V+  +  ++
Sbjct: 1464 LEPLGRRKKQLESSRAKLQIS--RDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQ 1521

Query: 693  GLHQSIEEFQAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKARLRSLE 749
             L   I     ++E       QL  A     +D    LG L   + +L  ++  RL+ L 
Sbjct: 1522 TLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLR 1581

Query: 750  SLH---SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 806
              +    +   A +   W+ E+E   +  +            + +    R +E   + IK
Sbjct: 1582 DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIK 1641

Query: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
            +L +    LL   HP    +   Q  +   ++ +  +    E   ++    +  F   RE
Sbjct: 1642 QLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVA---EERKRKLENMYHLFQLKRE 1698

Query: 867  AEGQLQKLQE 876
             +   Q + E
Sbjct: 1699 TDDLEQWISE 1708



 Score = 35.0 bits (79), Expect = 0.49
 Identities = 46/190 (24%), Positives = 78/190 (41%), Gaps = 29/190 (15%)

Query: 646  RRPELEDSTLRY-----LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE- 699
            RR +L D+  ++      +DLL+W+E    +++  E   D+ SVE  +  H+G++  IE 
Sbjct: 1895 RRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIET 1954

Query: 700  ---EFQAKIERARS---DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753
                F A +E   S    + Q S   R   +  + R      K   +   RLR L  +  
Sbjct: 1955 RSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEK-WEARWERLRMLLEVCQ 2013

Query: 754  FVAAATKELMWLNEKEEEEVGFDWS----------------DRNTNMTAKKESYSALMRE 797
            F   A+    WL  +E      D+                 +++T   A++ +       
Sbjct: 2014 FSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTT 2073

Query: 798  LELKEKKIKE 807
            LELKE++I E
Sbjct: 2074 LELKERQIAE 2083


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
           [Homo sapiens]
          Length = 2564

 Score =  299 bits (766), Expect = 1e-80
 Identities = 240/804 (29%), Positives = 376/804 (46%), Gaps = 79/804 (9%)

Query: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229
           DER+ VQKKT TKWVN HL +   HI DLY DLRDG  L  LLEVLSG+ LPR  +GRMR
Sbjct: 57  DEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMR 116

Query: 230 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288
            H L+NV  AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI  I++  +  
Sbjct: 117 IHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDN 176

Query: 289 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347
            E  +AK+ LLLW Q    GY  +   NFT+SWRDG  FNA+IHRH+P L+D +K+ +  
Sbjct: 177 RETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSN 236

Query: 348 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406
              NL +AF  AE+ LG+ RLLDPEDV++  PDEKSIITYV S Y    ++  +  +G R
Sbjct: 237 ANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR 296

Query: 407 AN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459
                    E+    + Y EL   LL W+         ++F +S   ++     F  +  
Sbjct: 297 IGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCT 356

Query: 460 MELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAILEREKQ 516
           +E P K  +K   + +  S++  ++A   +L VP  G    D++K WG+L  A  ERE  
Sbjct: 357 LEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAA 416

Query: 517 LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573
           LR+E  R E L+ +  +   +  + E  L++   L+  D     L A     ++   +E 
Sbjct: 417 LRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476

Query: 574 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 633
           D+   +  ++ +    Q L         + Y  + R+  +  ++  ++ L L   V A  
Sbjct: 477 DIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARR 528

Query: 634 TQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 692
           T++ Q + LQ V +        + Y+ D   W+EE Q ++   E G  L   +  L  H 
Sbjct: 529 TRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDLLQKHG 578

Query: 693 GLHQSIEEFQAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQYAKLLN 739
            L   I     ++E   +              + Q+          CL  L  Q A+   
Sbjct: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR--- 635

Query: 740 SSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDRNTNMT 785
             +A L +  SL + +    +   W  +KE                  G      + + T
Sbjct: 636 -RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694

Query: 786 AK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------AALQTQ 836
           A+    +  L  EL  +   +++    G+ L+       P  ++          A+ + +
Sbjct: 695 ARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRR 754

Query: 837 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDL 896
           W  + +     E  L+E  A  QF +D+   +G L  L++A R   + D          L
Sbjct: 755 WQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEASSRRL 811

Query: 897 LQDAQDEKEQLNEYKGHLSGLAKR 920
            +  +    ++  ++G +SGL ++
Sbjct: 812 ARQHRALTGEVEAHRGPVSGLRRQ 835



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 208/1021 (20%), Positives = 369/1021 (36%), Gaps = 169/1021 (16%)

Query: 426  QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 484
            +W+RH     E  +     E+IE    Q ++ K  EL A    K    +  +  LE   Q
Sbjct: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400

Query: 485  AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 532
            A   ++        + + + +L   +L  E QL+            S+ ++L+ ++  V 
Sbjct: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460

Query: 533  KLQMEAGLCE------------------------EQLHQADALLQSDIRLLAAGK-VPQR 567
            +   E G  +                        E+L +    LQ   RLL A K + Q 
Sbjct: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520

Query: 568  AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 613
            A +++ +L      + L       N +Q ++  +H +  Q  RR  + H        ER 
Sbjct: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578

Query: 614  --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 665
              L ++R+     ++ G+    +  A +  ++ +RR ++ D+  +  Q      ++ AW+
Sbjct: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637

Query: 666  EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIE------RARSDEGQLSPAT 719
             E +  +   + G D  S    L  H  L Q +E ++  I       RA  + G      
Sbjct: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697

Query: 720  RGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE----EEEVGF 775
                +  + RL +   +L    +  L     L+      ++   W+ EKE      E+G 
Sbjct: 1698 ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQ 1757

Query: 776  DWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTVESFQAALQ 834
            D+     +++  +E +S    E  +   +++  +    D L+   H A  T+  ++  L 
Sbjct: 1758 DFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 1813

Query: 835  TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL--------RRKNSCDR 886
              W+ +L+L       L  +    +FFSD RE +GQ+++ +  L         R ++   
Sbjct: 1814 EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 1873

Query: 887  SATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKPRHPAHPMR 937
              T+   E  LQ    +  QL E        Y G H   +A R + V+Q           
Sbjct: 1874 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ----------- 1922

Query: 938  GRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 997
            G   LL+ C+  ++ V+            A   H +V         + S       P   
Sbjct: 1923 GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIGAADKPRD- 1973

Query: 998  VQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------WSLATFRTL 1050
               +V  L   HQ L T   +L   +  L   Q L R + L +S         L    T 
Sbjct: 1974 -VSSVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTR 2029

Query: 1051 KPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQ 1103
            K E   +           LE+H  A      DA     ++ L+  RE GS     +QL++
Sbjct: 2030 KEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSVDEVEQLIR 2088

Query: 1104 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1163
              E   +  +  +   S L+ +          T+ +++    K+P      R     K  
Sbjct: 2089 RHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR-----KFF 2134

Query: 1164 AEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1222
             +   L    A L         L P    A+ TL +E+   +G + Q          +LK
Sbjct: 2135 GDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----------ELK 2184

Query: 1223 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA- 1281
               L  R  +  E   R     L    A P    E  AT A+ +++R + E Q+    A 
Sbjct: 2185 PERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPERQESADRAE 2241

Query: 1282 -----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1336
                  R E + + +  E   +R      E        +  L R++ +  + + R+R LE
Sbjct: 2242 ELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLE 2301

Query: 1337 Q 1337
            +
Sbjct: 2302 R 2302



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 149/797 (18%), Positives = 295/797 (37%), Gaps = 141/797 (17%)

Query: 658  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSP 717
            L  LL W+ +        ++G D  S       HR L   +E  +  +   R     L  
Sbjct: 782  LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841

Query: 718  ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 769
            A+       A +  +   +  +A++   +  R   LR   +++          +W+ EKE
Sbjct: 842  ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901

Query: 770  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 829
            +  +     D   ++   +  + +L +E+     ++ ++ +    L+   HP+   V S 
Sbjct: 902  QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961

Query: 830  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSA- 888
            Q  L ++W+ +++L   +E   +E +A     + V E      +++E  R   S  R+  
Sbjct: 962  QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018

Query: 889  ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 922
                 ++ LE  LQ  +  +  L E    L+                       LA  A+
Sbjct: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078

Query: 923  AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 952
            A  +                      ++ +  A    G LP        LLA     + E
Sbjct: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138

Query: 953  VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQAL 1012
            V   + D  ++V  ++     +L++ G+E            P   + E +  LE     L
Sbjct: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184

Query: 1013 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 1058
            + LW      +     +Q   RD++    ++R+  +A      P          ++ R  
Sbjct: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244

Query: 1059 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 1118
            L ++EL  Q      Q A G   +  +  E+         + + + LE+  + + R Q+ 
Sbjct: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297

Query: 1119 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1168
            + +L D +L+L+    R  H L      ++ + ++  RE      +R    Q   AE+  
Sbjct: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355

Query: 1169 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1227
              + + ++  E ++++   PE + +      E+     +LE      A  L +      +
Sbjct: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415

Query: 1228 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1281
            ++     ++ L   E QL++         V + L +L++ ++ +++   +    Q    A
Sbjct: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475

Query: 1282 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1341
            L  E    + VGER Q   GER V +      +  L ER + +LA      +EL Q+   
Sbjct: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523

Query: 1342 LRYYRESADPLGAWLQD 1358
            L       D   AW+Q+
Sbjct: 1524 L-------DDELAWVQE 1533



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 87/389 (22%), Positives = 148/389 (38%), Gaps = 53/389 (13%)

Query: 996  QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--E 1053
            ++ QEAVTRL  ++Q       Q    +   L  Q   RD   +  W        +    
Sbjct: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333

Query: 1054 EQRQALHSLELHYQAFL--------------RDSQDAGGFGPEDRLMAEREYGSCSHHYQ 1099
            E    LH   L +QAF+              R+ Q      PE      ++ G      +
Sbjct: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI----R 1389

Query: 1100 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRI 1156
            Q    LE   Q ++R     S+   +       + + +H      D +P  + A    ++
Sbjct: 1390 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 1449

Query: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
             + Q  +++VE   + V  L A+     ALP   PA+  L  E +  +G+   VR     
Sbjct: 1450 KKLQSMESQVEEWYREVGELQAQTA---ALPL-EPASKELVGERQNAVGE-RLVR----- 1499

Query: 1217 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA-VPATLPE-----LEATKASLKK--- 1267
             LE L+    ++  ++   +V    +++L   Q  +P  +       L+A +  +KK   
Sbjct: 1500 LLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQG 1559

Query: 1268 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1327
            LR + +A  P  +          EV ER       R  E E  R  + QL   W  +   
Sbjct: 1560 LRREIQAHGPRLE----------EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREA 1609

Query: 1328 TDVRQRELEQLGRQLRYYRESADPLGAWL 1356
             + RQ+ L+   +  +YY + A+ + AWL
Sbjct: 1610 AERRQQVLDAAFQVEQYYFDVAE-VEAWL 1637



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 198/958 (20%), Positives = 363/958 (37%), Gaps = 165/958 (17%)

Query: 506  LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVP 565
            L V ++E E QL +E   +  L+R   +  +       ++H  +  +    + L + +VP
Sbjct: 852  LQVRVVEAE-QLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVP 910

Query: 566  QRAGEVE----------RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER-- 613
                +VE          ++++     +  + + VQ L +G HP  +++      L+ R  
Sbjct: 911  DSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWN 970

Query: 614  ----LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQ 669
                LV  R E  +     V     +VA+V  Q  ++R  +E +                
Sbjct: 971  RIVELVEQRKE-EMSAVLLVENHVLEVAEVRAQVREKRRAVESAP--------------- 1014

Query: 670  HRVDGA-EWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLG 728
             R  GA +W   L  +EA L       Q++E  QA +    +   +  PA          
Sbjct: 1015 -RAGGALQWR--LSGLEAAL-------QALEPRQAALLEEAALLAERFPAQAARLHQGAE 1064

Query: 729  RLDLQYAKLLNSSKA---RLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--N 783
             L  ++  L ++++A    + +   L  F+      L WL   +E   G +    N+   
Sbjct: 1065 ELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEE 1124

Query: 784  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARP---TVESFQAALQTQWSWM 840
              A    ++AL  E++ +E+    +  A + LL  D         ++ +   L+  W  +
Sbjct: 1125 ADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKL 1184

Query: 841  LQLCCCIEAHLKENAAYFQFFSDVREA----------------EGQLQKLQEALRRKNSC 884
            L L       L +   Y  F  D+R+A                 G ++ ++EAL++    
Sbjct: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHR-- 1242

Query: 885  DRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLA 944
            D   T+   +  +Q A    E L   +G++ G  +  +AV +L  ++  + +R +  +  
Sbjct: 1243 DFLTTMELSQQKMQVAVQAAEGLLR-QGNIYG-EQAQEAVTRLLEKNQENQLRAQQWMQK 1300

Query: 945  VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTR 1004
            + D  Q+E+     D  +L G     H K+L +                  +E    + +
Sbjct: 1301 LHD--QLELQHFLRDCHELDGWI---HEKMLMARDG--------------TREDNHKLHK 1341

Query: 1005 LEAQHQALVTLWHQLHVDMKSLLAW-QSLRRDVQLIRSWS--LATFRTLKPEEQRQALHS 1061
               +HQA +        ++     W + + R+ Q +      LA     K  E RQ    
Sbjct: 1342 RWLRHQAFMA-------ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 1394

Query: 1062 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE 1121
            LE   QA  R   +A     +  + +  E      H +  LQ ++ G  + +     + +
Sbjct: 1395 LESTTQAKARQLFEASK--ADQLVQSFAELDKKLLHMESQLQDVDPGG-DLATVNSQLKK 1451

Query: 1122 LKDIRLQLEAC--ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1179
            L+ +  Q+E    E   +      L  EPA +  + + E+Q A  E   L + +  L   
Sbjct: 1452 LQSMESQVEEWYREVGELQAQTAALPLEPASK--ELVGERQNAVGE--RLVRLLEPLQER 1507

Query: 1180 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK---LKTISLVIRGTQGAEE 1236
               +LA  E    A  L  EL        Q R   A+  E+   L+ +   I+  QG   
Sbjct: 1508 RRLLLASKELHQVAHDLDDELAWV-----QERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562

Query: 1237 VLRAH----EEQLKEAQAVPATL-PELEATKASLKKL-------RAQAEAQQPTFDA--- 1281
             ++AH    EE L+ A A+ +   PE EA +  L++L       R  AE +Q   DA   
Sbjct: 1563 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 1622

Query: 1282 ---------------------LRDELRGAQEVGE-RLQQRHGERDVEVERWRERVAQLLE 1319
                                 +  E +G  E    +L ++H + +  VE + E +AQL  
Sbjct: 1623 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 1682

Query: 1320 RWQAVL-------AQTDVRQRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQ 1367
            + +A+L        Q   RQ ++++L    ++L   R  A     WL    R+  +++
Sbjct: 1683 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 1740



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 204/1044 (19%), Positives = 375/1044 (35%), Gaps = 186/1044 (17%)

Query: 413  RWQEYRELVLLLLQWM--RHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
            R Q +   +   L W+      A   E   P+S EE + L ++    KE E+  +E D  
Sbjct: 1089 RLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKE-EVDQREEDYA 1147

Query: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLD-----VEKEWGKLHVAILEREKQLRSEFERLE 525
            R   I  + E  + A   ++ PG   LD     +E  W KL + + E  ++   +    +
Sbjct: 1148 R---IVAASEALLAADGAELGPGL-ALDEWLPHLELGWHKL-LGLWEARREALVQAHIYQ 1202

Query: 526  CLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLL 585
               R               L QA  +L++    L+  ++P     VE  L +    +  +
Sbjct: 1203 LFLR--------------DLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTM 1248

Query: 586  FNDVQTLK------DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQV 639
                Q ++      +G   QG     +      RL+    E  LR            AQ 
Sbjct: 1249 ELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLR------------AQQ 1296

Query: 640  TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV-DGAEWGVDLPSVEAQLGSHRGLHQSI 698
             +Q +  + EL+   LR   +L  W+ E      DG     D   +  +   H+     +
Sbjct: 1297 WMQKLHDQLELQHF-LRDCHELDGWIHEKMLMARDGTR--EDNHKLHKRWLRHQAFMAEL 1353

Query: 699  ---EEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL------- 748
               +E+  KIER      Q  P    + R  LG +   +A+L ++++A+ R L       
Sbjct: 1354 AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKAD 1413

Query: 749  ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNT------NMTAKKESYSALMRELELK- 801
            + + SF     K L   ++ ++ + G D +  N+      +M ++ E +   + EL+ + 
Sbjct: 1414 QLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQT 1473

Query: 802  ---------EKKIKELQNA-GDRLLREDHPARP------------------------TVE 827
                     ++ + E QNA G+RL+R   P +                           E
Sbjct: 1474 AALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQE 1533

Query: 828  SFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRS 887
                A+QT+    LQ    ++ H+K+N          RE +    +L+E L      +R+
Sbjct: 1534 RLPLAMQTERGNGLQ---AVQQHIKKNQGLR------REIQAHGPRLEEVL------ERA 1578

Query: 888  ATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK-------AVVQLKPRH----PAHPM 936
              +  L     +A+  +  L + +   +GL + A+       A  Q++  +         
Sbjct: 1579 GALASLRS--PEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 1636

Query: 937  RGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLV----P 992
             G   LL + + K  +    +    QL+         V +   S A +   C  +     
Sbjct: 1637 LGEQELLMMSEDKGKD----EQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 1692

Query: 993  PPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP 1052
            P ++++    ++++  + AL  L  +  V ++       L R V  +  W          
Sbjct: 1693 PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 1752

Query: 1053 EEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER----EYGSCSHHYQQLLQSLEQG 1108
             E  Q    + +  + F   + + G  G E RL A      E   C H     +   + G
Sbjct: 1753 PELGQDFEHVSVLQEKFSEFASETGMAGRE-RLAAVNQMVDELIECGHTAAATMAEWKDG 1811

Query: 1109 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1168
              E       + EL   R QL A                 +RE  +  ++ ++ Q ++E 
Sbjct: 1812 LNE---AWAELLELMGTRAQLLAA----------------SRELHKFFSDARELQGQIEE 1852

Query: 1169 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1228
              + + RL+         PEP P+A    S ++ TL   E    L    + +L+  +  +
Sbjct: 1853 KRRRLPRLTTP-------PEPRPSA----SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 1901

Query: 1229 RGTQGAE--EVLRAHEEQL----KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1282
            R     E  E + + E+++    KE  +         ++ A   +  +Q        D +
Sbjct: 1902 RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGI 1961

Query: 1283 RDELRGAQEVG-----ERLQQRHGERDVEVERWRERVAQLLERWQAVL----AQTDVRQR 1333
              ++  A +       E L   H     E+E     +    E  +++L    A  D  Q 
Sbjct: 1962 ASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021

Query: 1334 ELEQLGRQLRYYRESADPLGAWLQ 1357
            +L++LG +     E  D    WLQ
Sbjct: 2022 QLDKLGTRKEEVSEKWDRHWEWLQ 2045



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 146/723 (20%), Positives = 271/723 (37%), Gaps = 62/723 (8%)

Query: 515  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERD 574
            ++L +E+  L    +   +    AG  +  LH  DA L   +R   A    +  G +   
Sbjct: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121

Query: 575  LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 633
            L++AD+++         LK+    Q E+ Y R+    E L+A    E    L      P 
Sbjct: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176

Query: 634  TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 686
             ++    L  +   RR  L  +      LR L+  L  +   +  + GAE    + SVE 
Sbjct: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236

Query: 687  QLGSHRGLHQSIEEFQAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 742
             L  HR    ++E  Q K++ A ++ EG L         A       L+      L + +
Sbjct: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296

Query: 743  --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 800
               +L     L  F+    +   W++EK          D N  +  +   + A M EL  
Sbjct: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355

Query: 801  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 860
             ++ +++++  G +L++E      +V      ++  W+ +          L E +   Q 
Sbjct: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415

Query: 861  FSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSG---- 916
                 E + +L  ++  L+  +     ATV      LQ  + + E+     G L      
Sbjct: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475

Query: 917  ----------LAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK-GDECQLVG 965
                      + +R  AV +   R    P++ R  LL     K++    H   DE   V 
Sbjct: 1476 LPLEPASKELVGERQNAVGERLVR-LLEPLQERRRLLLAS--KELHQVAHDLDDELAWVQ 1532

Query: 966  PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQ----EVQEAVTRLEAQHQALVTLWHQLHV 1021
               P   +    +G +A    +       NQ    E+Q    RLE   +    L      
Sbjct: 1533 ERLPLAMQTERGNGLQAVQQHI-----KKNQGLRREIQAHGPRLEEVLERAGAL-----A 1582

Query: 1022 DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGP 1081
             ++S  A +++RR ++ ++S + A  R    E ++Q L +     Q +   ++     G 
Sbjct: 1583 SLRSPEA-EAVRRGLEQLQS-AWAGLRE-AAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 1639

Query: 1082 EDRLMAEREYGSCSHHYQQLLQ---SLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 1138
            ++ LM   + G       QLL+    LEQG +        +S      L++   ++  + 
Sbjct: 1640 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQIS 1699

Query: 1139 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1198
            R +  +D+       + + E+++   E +     ++R  +E E  +A  E    +P L  
Sbjct: 1700 RRQSQVDR--LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQ 1757

Query: 1199 ELE 1201
            + E
Sbjct: 1758 DFE 1760



 Score = 38.9 bits (89), Expect = 0.034
 Identities = 56/236 (23%), Positives = 89/236 (37%), Gaps = 24/236 (10%)

Query: 1149 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1197
            +REC Q + E           + ++    + V  L+A A +   L    P  P +     
Sbjct: 560  SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619

Query: 1198 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1257
            + +   L +L++  +     LE  +++  +++  + AE   R  E  L+ A    A    
Sbjct: 620  NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679

Query: 1258 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1305
              A  A       S  +L AQ +  Q      R  L+ A   GE L    G        V
Sbjct: 680  GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739

Query: 1306 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1361
             +    ER A    RWQ +      R+R L++  R L  +    D L  WL+DA R
Sbjct: 740  HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYR 794



 Score = 35.8 bits (81), Expect = 0.29
 Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)

Query: 374  VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 430
            +++  PD + I    + V  LY A+  + + +    A E Q    +    V  L  W+  
Sbjct: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745

Query: 431  HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 490
                         FE + +L     KF E       A + R   + Q ++  ++ G    
Sbjct: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802

Query: 491  PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQAD 549
                   D + + W +L   +  R + L +  E    L +  +  +   G  EE+  +  
Sbjct: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858

Query: 550  ALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 609
                   RL    +    A  ++R L   +  ++LL + V+ L++G         R VY 
Sbjct: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906

Query: 610  -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 665
              H   +A R +  L+    + + A + A++ + S           LR+   ++DLL+W+
Sbjct: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958

Query: 666  EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFQAKIERARS---DEGQLSPA 718
            +    ++  A+   D+ SVE  +  H+GL   +E    E     E  RS   ++  ++  
Sbjct: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018

Query: 719  TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 769
             + A  D LG    + ++  +     L+ +  +H F   A     WL  +E
Sbjct: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068


>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
          Length = 3639

 Score =  254 bits (648), Expect = 5e-67
 Identities = 313/1256 (24%), Positives = 509/1256 (40%), Gaps = 163/1256 (12%)

Query: 175  RVQKKTSTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 231
            ++Q+KT TKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP   +GR+R H
Sbjct: 19   QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78

Query: 232  KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 291
             L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I +  +    
Sbjct: 79   FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137

Query: 292  TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346
            +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L+D   +   
Sbjct: 138  SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197

Query: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 406
              L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R+   Q   R
Sbjct: 198  RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257

Query: 407  --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458
                      E +L   +Y +LV  LL+W+       E R FP S   +  L + F  F+
Sbjct: 258  RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317

Query: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 514
              E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  L  A   R 
Sbjct: 318  TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376

Query: 515  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQS----DIRLLAAGKVPQRAGE 570
            + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L       QR G 
Sbjct: 377  QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436

Query: 571  VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 630
            +E  +   +   + L      L+  ++     + RR     +  V +R +   RL   + 
Sbjct: 437  LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488

Query: 631  APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 689
                QVA +  + S+ +  E     L  LQ+        Q   +  E       +EAQ+ 
Sbjct: 489  GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548

Query: 690  SHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 749
            +H      + +  A+++ +     ++  A        L +L      L+ + +A L    
Sbjct: 549  AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604

Query: 750  SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 809
                F+    +E  WL E  +           + +    + + AL  E+   +    +L 
Sbjct: 605  QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664

Query: 810  NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 869
              G  L     P +P       A+Q  W  +        A L+      Q+F+D  EA  
Sbjct: 665  RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724

Query: 870  QLQKLQEALRRKNSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 921
             L++ + +L R  SC  D++A  T      RLE +L+    E  +L E     S  A   
Sbjct: 725  WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783

Query: 922  KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 981
                 L P  P   +R   P      + +       GD  ++  PA+P            
Sbjct: 784  TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824

Query: 982  AAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 1041
               P      P    + Q+ +++     +AL  L      +  +L  + S   ++QL   
Sbjct: 825  ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878

Query: 1042 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 1098
                  + ++P  Q   L  ++L Y+ FL       G   E    AE   + Y   S   
Sbjct: 879  KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936

Query: 1099 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1133
            Q+  + L Q  G  E  + ++ +                    +L+D+ LQLEA +    
Sbjct: 937  QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996

Query: 1134 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1192
              T H L+L   K    E  +R+   Q    +VE                    EP  A 
Sbjct: 997  EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034

Query: 1193 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1252
            +  L+ ++E   G L+QV+                       E+V +    Q  E QA  
Sbjct: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070

Query: 1253 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1312
            + L E +      + ++AQ  +++ + D             +RL + H +   E+  W+E
Sbjct: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121

Query: 1313 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQE 1364
            R+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+    Q+
Sbjct: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQK 1177



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 188/885 (21%), Positives = 331/885 (37%), Gaps = 136/885 (15%)

Query: 509  AILER-EKQLRSEFERLECLQR--IVTKLQMEAGLCEEQLHQADALLQSDIRLLA----- 560
            AILE  +K LR    RLE LQ    +  LQ++A +   +LHQ   L   ++  +A     
Sbjct: 1455 AILEETQKHLR----RLELLQGHLAIRGLQLQASV---ELHQFCHLSNMELSWVAEHMPH 1507

Query: 561  ------------AGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVY 608
                        A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +  
Sbjct: 1508 GSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQ 1567

Query: 609  RLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN 668
             L      +      R            AQ   Q+V  +    D     + +L  WVEE 
Sbjct: 1568 ELEGHWAELERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEK 1610

Query: 669  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLS-PATRGAYRDCL 727
            +  V   ++G D  +    +  H+ L + +  + + +E        L+ P      R   
Sbjct: 1611 RPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQ 1670

Query: 728  GRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTN 783
             RL  Q   L   +  R R LE    LH F+  A     WL ++K+  + G    +   +
Sbjct: 1671 ERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEH 1730

Query: 784  MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 843
                   ++    ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L
Sbjct: 1731 ALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWEL 1790

Query: 844  CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDE 903
                   L++     +   D+ E   Q+Q+   +L    + D    +  LE  L+  Q  
Sbjct: 1791 TQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARD----LCGLEAQLRSHQGL 1846

Query: 904  KEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQL 963
            + +L   +  L  L + A  V +L P   AH ++ R          Q  VT         
Sbjct: 1847 ERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQR----------QQAVT--------- 1887

Query: 964  VGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDM 1023
                    W VL                    + +++   +LE        L  +    +
Sbjct: 1888 ------QAWAVL-------------------QRRMEQRRAQLER-----ARLLARFRTAV 1917

Query: 1024 KSLLAWQS-LRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 1082
            +   +W + +R+D+Q+  S    +   LK    +     LE   + +    Q A   G +
Sbjct: 1918 RDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLW----QQATQLGQQ 1973

Query: 1083 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1142
              L A           + L    +Q  Q  +R Q  +   +  +L L  C      RL  
Sbjct: 1974 ALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLREC-----GRLEE 2028

Query: 1143 PLDKEPARECAQRIAEQQKAQAEVEGLGKG----VARLSAEAEKVLALPE--PSPAAPTL 1196
             L    A+E + + +    +  EVE L +     +  L+A+ +K  AL E   +   P +
Sbjct: 2029 IL---AAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRV 2085

Query: 1197 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG---AEEVLRAHEEQLKEAQAVPA 1253
            R  L + L +  +V+ L+      L    L+   TQ    AE+ ++A  +QLKE    P 
Sbjct: 2086 RDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKE-PVPPG 2144

Query: 1254 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1313
             L   +  K  LK    +AE Q     A  + +    + GE L  +   R  EV    +R
Sbjct: 2145 DL--RDKLKPLLKHQAFEAEVQ-----AHEEVMTSVAKKGEALLAQSHPRAGEVS---QR 2194

Query: 1314 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1358
            +  L + W+ +     +R +ELE   R    + +  D   AW+Q+
Sbjct: 2195 LQGLRKHWEDLRQAMALRGQELED-RRNFLEFLQRVDLAEAWIQE 2238



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 101/434 (23%), Positives = 169/434 (38%), Gaps = 33/434 (7%)

Query: 497  LDVEKEWGKLHVAILEREKQLRSEFERL------------ECLQRIVTKLQMEAGLCEEQ 544
            L   +E+G+L   +  R + LR+  E+L            E LQ I  +     G  E++
Sbjct: 1212 LQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQR 1271

Query: 545  LHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMY 604
              Q  A LQ         ++ Q   E  + L  A        N +QTLK  RH   E   
Sbjct: 1272 RRQLLASLQLQEWKQDVAELMQWMEE--KGLMAAHEPSGARRNILQTLK--RHEAAESEL 1327

Query: 605  RRVYRLHERLVAIRTEYNLRLKAGVAAPATQVA-------QVTLQSVQRRPELE-----D 652
                R  E L  +  E   R   G     T++         +  +  +R  EL+     +
Sbjct: 1328 LATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQE 1387

Query: 653  STLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDE 712
              LR LQD    +E+ +  +  +E G DL S +     H+ L        AK+    S  
Sbjct: 1388 QLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMA 1447

Query: 713  GQL--SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770
              +  SPA     +  L RL+L    L         S+E LH F   +  EL W+ E   
Sbjct: 1448 HGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVE-LHQFCHLSNMELSWVAEHMP 1506

Query: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP-ARPTVESF 829
                  +++      +    +  L  E++  + +++ + ++G  L    HP A+  VE  
Sbjct: 1507 HGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQC 1566

Query: 830  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSAT 889
            Q  L+  W+ + + C      L++   + Q+F DV E EG +++ +  +  ++     A 
Sbjct: 1567 QE-LEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAA 1625

Query: 890  VTRLEDLLQDAQDE 903
              RL +  Q  Q+E
Sbjct: 1626 TLRLINKHQALQEE 1639



 Score = 61.6 bits (148), Expect = 5e-09
 Identities = 199/963 (20%), Positives = 351/963 (36%), Gaps = 150/963 (15%)

Query: 408  NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEI---EILWSQFLKFKEMELPA 464
            + L+  WQE++  +   L+     ++  +  R+  S E+    E LW      + +    
Sbjct: 2524 SSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKH 2583

Query: 465  K--EADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---KQLRS 519
            K  E D     G   +LE   +     +  G HP + +   G+    +L +E   +Q  +
Sbjct: 2584 KMLEWDLEVQAGKISALEATARG----LHQGGHP-EAQSALGRCQAMLLRKEALFRQAGT 2638

Query: 520  EFERLECLQRIVTKLQ----MEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDL 575
               RLE L+++   LQ    + A L E+ L   +  L     L A     Q+    + +L
Sbjct: 2639 RRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQ---LQKQQNFQAEL 2695

Query: 576  DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ 635
            D +    + L  + Q L  G HP  E +  R+    E L A+  E     +  VA     
Sbjct: 2696 DASMHQQQELQREGQRLLQGGHPASEAIQERL----EELGALWGELQDNSQKKVAK---- 2747

Query: 636  VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH 695
              Q   ++++ R        R +++L  W+E  +  +     G  LP V   LG+ R L 
Sbjct: 2748 -LQKACEALRLR--------RSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELE 2798

Query: 696  QSIEEFQAKIERARSDEGQLSPATRGAYRDCLGR-LDLQYAKLLNSSKA-------RLRS 747
             ++++   K  +A +  GQ     R  +  CL + ++ Q  +LL   K+       R  +
Sbjct: 2799 AAVDK---KARQAEALLGQAQAFVREGH--CLAQDVEEQARRLLQRFKSLREPLQERRTA 2853

Query: 748  LES---LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 804
            LE+   L  F   A +E+ W+ EK       D+    + +   +E +  L  E+   E  
Sbjct: 2854 LEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEAL 2913

Query: 805  IKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDV 864
             + +   G +L++  H A                          AH              
Sbjct: 2914 TRVVLGTGYKLVQAGHFA--------------------------AH-------------- 2933

Query: 865  REAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAV 924
             E   ++Q+L++A+         A   R   LLQ AQ+ ++ L E     S LA+R   +
Sbjct: 2934 -EVAARVQQLEKAMAHLR-----AEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVL 2987

Query: 925  VQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAV 984
                  H A   +  L        +++E T     + +   P              E   
Sbjct: 2988 DSEDMGHSAEATQALL--------RRLEATKR---DLEAFSPR------------IERLQ 3024

Query: 985  PSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHV---DMKSLLAWQSLRRDVQLIRS 1041
             +   L    N E  + + +L+A  +A   L  +       ++  L    L R+  L+ +
Sbjct: 3025 QTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDA 3084

Query: 1042 WSLATFRTLKPEEQRQALHS---LELHYQAFLRDSQDAGGF---------GPEDRLMAER 1089
            W      T + ++  Q L     LE  + AF ++ Q  G           G  +R  A R
Sbjct: 3085 WLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLER-GAPR 3143

Query: 1090 EYGSCSHHYQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1146
             Y        ++    + L+Q  +  +       E+   +      + R   +  L   +
Sbjct: 3144 RYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGE 3203

Query: 1147 EPARECAQ-RIAEQQ--KAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT 1203
            +     +  R  +QQ  + + E+E + K VARL  EA ++  L   +P       E   T
Sbjct: 3204 DGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWAT 3263

Query: 1204 LGKLEQVR----SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1259
            L    Q R    + +A     L     ++   Q  +E L + EE  ++       L + E
Sbjct: 3264 LQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQE-LASSEELAEDVAGAEQLLGQHE 3322

Query: 1260 ATKASLKKLRAQAEAQQPTFDALRDELR-GAQEVGERLQQRHGERDVEVERWRERVAQLL 1318
                 +++ R QA+  +     L D     + EV E LQ+  G      E W  R  +  
Sbjct: 3323 ELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCA 3382

Query: 1319 ERW 1321
            E W
Sbjct: 3383 ESW 3385



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 215/1011 (21%), Positives = 362/1011 (35%), Gaps = 206/1011 (20%)

Query: 494  YHP-LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALL 552
            YH   DV +   ++ V      + L+ + +++  +Q +++ LQ E      QL +    L
Sbjct: 463  YHSWADVARRQEEVTVRWQRLLQHLQGQRKQVADMQAVLSLLQ-EVEAASHQLEE----L 517

Query: 553  QSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHE 612
            Q   R  A G   Q+  EV   L + D +      + Q    G H         V  L +
Sbjct: 518  QEPARSTACG---QQLAEVVELLQRHDLL------EAQVSAHGAH---------VSHLAQ 559

Query: 613  RLVAIRTEYNLRLKAGVAAPAT--QVAQVTLQSVQRRPELEDSTL------RYLQDLLAW 664
            +   + +     ++   A   T  Q+ Q  +  V+ R  L + TL      R  ++  AW
Sbjct: 560  QTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQRAEFLRNCEEEEAW 619

Query: 665  VEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAK----IERARS---------- 710
            ++E   RV  A  G DL  +   L  H+ L   +   QA     + R R           
Sbjct: 620  LKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQP 679

Query: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEK-- 768
            D G+ + A +G ++       L   +++    ARL++   +  + A A +   WL E+  
Sbjct: 680  DPGERAEAVQGGWQ-------LLQTRVVGRG-ARLQTALLVLQYFADAAEAASWLRERRS 731

Query: 769  --EEEEVGFDWSD------RNTNMTAKKESYSALMRELELKEKKI--------------- 805
              E    G D +       R+  +     +++A +R LE + +                 
Sbjct: 732  SLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLFTVNSALSP 791

Query: 806  --KELQNAGDRLLREDHP-----------ARP-------TVESFQAALQTQWSWMLQLCC 845
              + L+N G       HP           A P       T+   Q  L   +  +  L  
Sbjct: 792  PGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQ 851

Query: 846  CIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRL------------ 893
               A L+E  A F F S   E +  L+K    L+R      +  V +L            
Sbjct: 852  LRRARLEEAMALFGFCSSCGELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVG 911

Query: 894  -----------EDLLQ-------DAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 935
                       E L Q         Q ++E+L++  G L  L KR KAV QL     AH 
Sbjct: 912  KGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEAL-KREKAV-QL-----AHS 964

Query: 936  MRGRLPLLAVCDYKQVEV--------TVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSV 987
            +      L  C   QV++         +  G         Q +  K L        + SV
Sbjct: 965  VEV-CSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRVHFLQSV 1023

Query: 988  CFLVPPPN------------------QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAW 1029
               V  P                   ++VQE V +  A+ QA          + + LL W
Sbjct: 1024 VVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQ-RARRQAETQARQSFLQESQQLLLW 1082

Query: 1030 ----QSLRRDVQLIRSWSLATFRTLKPEEQR--QALHSLELHYQAFLRDSQDAGGFGPED 1083
                Q+  R  ++  S  +A+ + L  E Q   + +H  +   Q     SQ        D
Sbjct: 1083 AESVQAQLRSKEV--SVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALDCPD 1140

Query: 1084 RLMAE---REYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL 1140
                    R  G      + L +  +Q  QE    Q+   E+           T   H+ 
Sbjct: 1141 SQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTA------TCANHQA 1194

Query: 1141 RLPLDK--EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1198
             L LD   E  RE    + + ++    +  LG     L A  EK++      PAA T+R 
Sbjct: 1195 WLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQ--SQHPAAHTVRE 1252

Query: 1199 ELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1258
            +L+    +  +++  S     +L     +    Q   E+++  EE+   A   P+     
Sbjct: 1253 QLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPS----- 1307

Query: 1259 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH--GERDVEVERWRERVAQ 1316
               + ++ +   + EA +    A R  +   Q+VG  L  R   G+ D++      R+  
Sbjct: 1308 -GARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQT-----RLQG 1361

Query: 1317 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367
            L  +W+A+  +   R  EL+Q G+Q +  R+        LQDA+ + EQ++
Sbjct: 1362 LRSKWEALNRKMTERGDELQQAGQQEQLLRQ--------LQDAKEQLEQLE 1404



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 155/748 (20%), Positives = 282/748 (37%), Gaps = 118/748 (15%)

Query: 646  RRPELED--STLRYLQ--DLL-AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEE 700
            R  ELED  + L +LQ  DL  AW++E + +++  + G DL            L + + E
Sbjct: 2212 RGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ-------LRRRLRE 2264

Query: 701  FQAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKARLRSL-ESLHSFVA 756
            F     R  S    +  A   +  D    L   D +  K++   +++L +   S H  + 
Sbjct: 2265 F-----RGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLL 2319

Query: 757  AATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKE--KKIKELQNAGDR 814
               ++L    E        D      N+T + +   AL++ L+  +  + ++ L    + 
Sbjct: 2320 RYQQQLEGALEIHVLSRELD------NVTKRIQEKEALIQALDCGKDLESVQRLLRKHEE 2373

Query: 815  LLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKL 874
            L RE HP +  VES +  +        +LC          AA+         AE   Q  
Sbjct: 2374 LEREVHPIQAQVESLEREVG-------RLC-----QRSPEAAHGLRHRQQEVAESWWQLR 2421

Query: 875  QEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAH 934
              A +R+ + D      +L+ +LQ+     ++L            RA+      PR P  
Sbjct: 2422 SRAQKRREALDALHQAQKLQAMLQELLVSAQRL------------RAQMDTSPAPRSPVE 2469

Query: 935  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 994
              R                 + +  EC+    +      +  S+G +           P 
Sbjct: 2470 ARR----------------MLEEHQECKAELDSWTDSISLARSTGQQLLTAG-----HPF 2508

Query: 995  NQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW------SLAT-- 1046
            + ++++ +  LE +  +L   W +  + ++  L  Q     V+ +  W      SLA+  
Sbjct: 2509 SSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG 2568

Query: 1047 -FRTLKPEEQRQALHSL---ELHYQAFLRDSQDAGGFG------PEDRLMAEREYGSCSH 1096
             +  L P E     H +   +L  QA    + +A   G      PE    A+   G C  
Sbjct: 2569 LWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPE----AQSALGRC-- 2622

Query: 1097 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE-----ACETRTVHRLRLPLDKEPARE 1151
              Q +L   E   ++    +  + EL+ ++  L+     A   R  + + L         
Sbjct: 2623 --QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAM 2680

Query: 1152 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR-SELELTLGKLEQV 1210
               ++ +QQ  QAE++        L  E +++L    P+  A   R  EL    G+L+  
Sbjct: 2681 LPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDN 2740

Query: 1211 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRA 1270
                   L+K      + R  +  E  L   E +L+ A  V   LP +     + ++L A
Sbjct: 2741 SQKKVAKLQKACEALRLRRSMEELENWLEPIEVELR-APTVGQALPGVGELLGTQRELEA 2799

Query: 1271 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1330
              + +    +AL  + +     G  L Q     DVE     E+  +LL+R++++      
Sbjct: 2800 AVDKKARQAEALLGQAQAFVREGHCLAQ-----DVE-----EQARRLLQRFKSLREPLQE 2849

Query: 1331 RQRELEQLGRQLRYYRESADPLGAWLQD 1358
            R+  LE     L+++R+ AD   AW+Q+
Sbjct: 2850 RRTALEARSLLLKFFRD-ADEEMAWVQE 2876



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 185/890 (20%), Positives = 328/890 (36%), Gaps = 141/890 (15%)

Query: 477  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 531
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444

Query: 532  TKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 591
             +L + A     Q+  + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500

Query: 592  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 648
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554

Query: 649  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 701
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612

Query: 702  QAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 759
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657

Query: 760  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716

Query: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756

Query: 880  RKNSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 934
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809

Query: 935  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 994
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843

Query: 995  NQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1054
             + +QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898

Query: 1055 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1114
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958

Query: 1115 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1170
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017

Query: 1171 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1230
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063

Query: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1287
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121

Query: 1288 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTD 1329
                     +++   L++    R   ++  R R+    ER  QA+ A+T+
Sbjct: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTE 3171



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 148/781 (18%), Positives = 297/781 (38%), Gaps = 105/781 (13%)

Query: 652  DSTLRYLQDLLAWVEENQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFQAKIERAR 709
            ++TLR  +DLL  + + Q +       V  DL  +EAQL SH+GL + +   + +++   
Sbjct: 1802 ETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELL 1861

Query: 710  SDEGQLSPATRGAYRDCLGRLDLQYAKL-------LNSSKARLRSLESLHSFVAAATKEL 762
               G++     G     + +      +        +   +A+L     L  F  A     
Sbjct: 1862 ETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYA 1921

Query: 763  MWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPA 822
             W     ++    + S   ++   K  ++  L  ELE +EK  ++    G + L      
Sbjct: 1922 SWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTP 1981

Query: 823  RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKN 882
               V+    ALQ Q   + Q     +  L+       F  +    E  L   + +L+   
Sbjct: 1982 TKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLK--- 2038

Query: 883  SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPL 942
            +    ++V  +E L++  +   + L       + L +R K +   +PR     +R RLP+
Sbjct: 2039 TSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTL--RRPR-----VRDRLPI 2091

Query: 943  LAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFL----------VP 992
            L     +  E+   +G            H  +L +S ++AA  +  ++          VP
Sbjct: 2092 LLQRRMRVKELAESRG---------HALHASLLMASFTQAATQAEDWIQAWAQQLKEPVP 2142

Query: 993  PPN------------------QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRR 1034
            P +                  Q  +E +T +  + +AL+   H    ++   L  Q LR+
Sbjct: 2143 PGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRL--QGLRK 2200

Query: 1035 DVQLIRSWSLATFRTLKPEEQRQALHSLEL--HYQAFLRDSQDAGGFGPEDRLMAEREYG 1092
              + +R       R  + E++R  L  L+     +A++++ +     G         + G
Sbjct: 2201 HWEDLR--QAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVG---------DLG 2249

Query: 1093 SCSHHYQQLLQSLEQ---GAQEESRCQRCISELKDIRLQL---EACETRTVHRLRLPLDK 1146
                H  QL + L +    +  ++    CI  + D+ LQL   +  E + + + R  L+ 
Sbjct: 2250 QDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNN 2309

Query: 1147 EPARECAQRIAEQQKAQA--EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTL 1204
              A      +  QQ+ +   E+  L + +  ++   ++  AL +       L S   L  
Sbjct: 2310 RWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLR 2369

Query: 1205 GKLEQVRSLSAI--YLEKL-KTISLVIRGTQGAEEVLRAHEEQLKEA------------Q 1249
               E  R +  I   +E L + +  + + +  A   LR  ++++ E+            +
Sbjct: 2370 KHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRRE 2429

Query: 1250 AVPATLPELEATKASLKKLRAQAE---AQQPTFDALRDELRGAQEVGERLQQRHGERDVE 1306
            A+ A L + +  +A L++L   A+   AQ  T  A R  +        R+ + H E   E
Sbjct: 2430 ALDA-LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVE-----ARRMLEEHQECKAE 2483

Query: 1307 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1366
            ++ W + ++      Q +L        ++ Q+   L     S +  GAW +   + Q+ +
Sbjct: 2484 LDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLE--GAWQEHQLQLQQAL 2541

Query: 1367 Q 1367
            +
Sbjct: 2542 E 2542



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 147/713 (20%), Positives = 276/713 (38%), Gaps = 76/713 (10%)

Query: 656  RYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQL 715
            R L ++   ++E +  +   + G DL SV+  L  H  L + +   QA++E    + G+L
Sbjct: 2336 RELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRL 2395

Query: 716  ---SPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSF--VAAATKELMWLNEKEE 770
               SP      R     +   + +L + ++ R  +L++LH    + A  +EL+   ++  
Sbjct: 2396 CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR 2455

Query: 771  EEVGFDWSDRNTNMTAKK-ESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 829
             ++    + R+     +  E +     EL+     I   ++ G +LL   HP    +   
Sbjct: 2456 AQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQV 2515

Query: 830  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSAT 889
             A L+ + S +       +  L++      F S V + E  L   +++L  +   D  A 
Sbjct: 2516 LAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAP 2575

Query: 890  VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP-AHPMRGRLPLLAVCD- 947
               +E LL   +  +  L    G +S L   A+ + Q    HP A    GR   + +   
Sbjct: 2576 ---MEPLLWKHKMLEWDLEVQAGKISALEATARGLHQ--GGHPEAQSALGRCQAMLLRKE 2630

Query: 948  --YKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRL 1005
              ++Q     H+ +E + +                        FL     Q+ QE    L
Sbjct: 2631 ALFRQAGTRRHRLEELRQLQ----------------------AFL-----QDSQEVAAWL 2663

Query: 1006 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 1065
              ++  LV L   L +D   L A    +++ Q     S+   + L+ E QR  L      
Sbjct: 2664 REKN--LVALEEGL-LDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQR-LLQGGHPA 2719

Query: 1066 YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1125
             +A     ++ G             +G    + Q+ +  L++ A E  R +R + EL++ 
Sbjct: 2720 SEAIQERLEELGAL-----------WGELQDNSQKKVAKLQK-ACEALRLRRSMEELEN- 2766

Query: 1126 RLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA 1185
               LE  E      LR P   +      + +  Q++ +A V+   +    L  +A+  + 
Sbjct: 2767 --WLEPIEVE----LRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVR 2820

Query: 1186 LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1245
              E    A  +  +    L + + +R         L+  SL+++  + A+E +   +E+L
Sbjct: 2821 --EGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKL 2878

Query: 1246 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1305
              A A       L A +  L++     E++  + +AL   + G    G +L Q       
Sbjct: 2879 PLAAAQDYG-QSLSAVR-HLQEQHQNLESEMSSHEALTRVVLGT---GYKLVQAGHFAAH 2933

Query: 1306 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1358
            EV     RV QL E+  A L     R+R L Q  ++ + +       G+WL +
Sbjct: 2934 EVAA---RVQQL-EKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAE 2982



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 173/785 (22%), Positives = 292/785 (37%), Gaps = 107/785 (13%)

Query: 601  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD 660
            E + RR  RL   L A   E     + G AA A + +  T+ S    P         L++
Sbjct: 746  ETLLRRHVRLERVLRAFAAELRRLEEQGRAASA-RASLFTVNSALSPPG------ESLRN 798

Query: 661  LLAWVEENQHRVDGAEWGVDLPSV-------EAQLGSHRGLHQSIEEFQA--KIERARSD 711
               W E + H   G  W + LP+           L +   L Q  E  +A  ++ RAR +
Sbjct: 799  PGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLSQDYESLRALAQLRRARLE 858

Query: 712  EGQLSPATRGAYRDCLGRLDLQYAK---LLNSSKARLRSLESLHSFVAAATKELMWLNEK 768
            E     A  G    C G L L   K   LL   + +  +LE +         +L + N  
Sbjct: 859  EAM---ALFGFCSSC-GELQLWLEKQTVLLQRVQPQADTLEVM---------QLKYENFL 905

Query: 769  EEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVE 827
                VG   W++ +++    ++ Y     +++ +++++ +     + L RE        +
Sbjct: 906  TALAVGKGLWAEVSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE--------K 957

Query: 828  SFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFS-----DVREAEGQLQKLQEALRRKN 882
            + Q A   +    LQ C   +  L++     +        D   A    QK    L R+ 
Sbjct: 958  AVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERRV 1017

Query: 883  SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGL----AKRAKAVVQLKPRHPAHPMRG 938
               +S  V   E    ++Q  + Q+   +G L  +    A+RA+   + + R        
Sbjct: 1018 HFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQ 1077

Query: 939  RLPLLAVCDYKQV---EVTVHKGDECQLVGPAQPS----HWKVLSSSGSEAAVPSVCFLV 991
            +L L A     Q+   EV+V      +L+   Q      H         +A    +  L 
Sbjct: 1078 QLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMAALD 1137

Query: 992  PPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLK 1051
             P +QEV   +  L  Q Q L  LW Q    ++  L  Q   R+V    +        L 
Sbjct: 1138 CPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLH 1197

Query: 1052 ----PEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1107
                 E+ R+AL  L+ H +      +     GP  R  A R +G      ++L+QS   
Sbjct: 1198 LDNLGEDVREALSLLQQHREF----GRLLSTLGP--RAEALRAHG------EKLVQSQHP 1245

Query: 1108 GAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVE 1167
             A           +L+ I+ Q    + R+  R R  L     +E  Q +AE  +   E +
Sbjct: 1246 AAHTVR------EQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEE-K 1298

Query: 1168 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK----LKT 1223
            GL       S     +L   +   AA    SEL  T   +E ++ +    L +     + 
Sbjct: 1299 GL-MAAHEPSGARRNILQTLKRHEAA---ESELLATRRHVEALQQVGRELLSRRPCGQED 1354

Query: 1224 ISLVIRGTQGAEEVLR----AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF 1279
            I   ++G +   E L        ++L++A      L +L+  K  L++L    ++ +   
Sbjct: 1355 IQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQ 1414

Query: 1280 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL------LERWQAVLAQTDVRQR 1333
            D     LR +Q    RLQ+RH + + E      ++A L      +    A+L +T    R
Sbjct: 1415 D-----LRSSQ----RLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLR 1465

Query: 1334 ELEQL 1338
             LE L
Sbjct: 1466 RLELL 1470


>gi|12025678 actinin, alpha 4 [Homo sapiens]
          Length = 911

 Score =  246 bits (628), Expect = 1e-64
 Identities = 147/396 (37%), Positives = 222/396 (56%), Gaps = 23/396 (5%)

Query: 174 DRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 232
           ++ Q+KT T W N HL KA   I ++ ED RDG  L+ LLEV+SG+ LP+ E+G+MR HK
Sbjct: 49  EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108

Query: 233 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 292
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164

Query: 293 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 352
           AKE LLLW QR    Y+ +   NF  SW+DG  FNA+IHRH+P LI+ +K+ +   + NL
Sbjct: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224

Query: 353 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 407
           + AF VAE+ L + ++LD ED V+  +PDEK+I+TYVSS Y A       +         
Sbjct: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284

Query: 408 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 463
                E +   ++Y +L   LL+W+R      E+R    + +E++     F  ++ +  P
Sbjct: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344

Query: 464 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 517
            K  +K + +  + +L+  +   +L   P + P       D+   W  L  A    E+ L
Sbjct: 345 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWL 401

Query: 518 RSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQ 553
            +E  RLE L  +  K + +A + E      +A+L+
Sbjct: 402 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437



 Score = 30.8 bits (68), Expect = 9.3
 Identities = 34/149 (22%), Positives = 62/149 (41%), Gaps = 4/149 (2%)

Query: 1221 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1280
            L  I  +IR  +  E  L AH++++++  A+   L EL+   +     R Q    Q  +D
Sbjct: 446  LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ--WD 503

Query: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1340
            AL       +E  E+ +++    D     + +R A     W    A  D++   +     
Sbjct: 504  ALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP-FNNWME-SAMEDLQDMFIVHTIE 561

Query: 1341 QLRYYRESADPLGAWLQDARRRQEQIQAM 1369
            ++     + D   + L DA R +E I A+
Sbjct: 562  EIEGLISAHDQFKSTLPDADREREAILAI 590


>gi|4557241 actinin, alpha 3 [Homo sapiens]
          Length = 901

 Score =  245 bits (625), Expect = 2e-64
 Identities = 203/636 (31%), Positives = 301/636 (47%), Gaps = 51/636 (8%)

Query: 174 DRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 232
           ++ Q+KT T W N HL KA   I ++ ED R+G  L+ LLEV+SG+ LPR +KG+MRFHK
Sbjct: 44  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103

Query: 233 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 292
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159

Query: 293 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 352
           AKE LLLW QR    Y+ +   NF +SW+DG    A+IHRH+P LID  K+ +   + NL
Sbjct: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219

Query: 353 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 407
           + AF VAE+ L + ++LD ED V+ P+PDEK+I+TYVS  Y A       +         
Sbjct: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279

Query: 408 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 463
                E +   +EY +L   LL+W+R      E R    S   ++     F  ++ +  P
Sbjct: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339

Query: 464 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 517
            +  +K + +  + +L+  +   +L   P + P       D+   W  L       E  L
Sbjct: 340 PRIQEKCQLEINFNTLQTKL---RLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396

Query: 518 RSEFERLECLQRIVTKLQMEAGL-------CEEQLHQAD---ALLQSDIRLLAAGKVPQR 567
            SE  RL+ LQ +  K + +A L        EE L Q D   ALLQ    LL      +R
Sbjct: 397 LSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALL------RR 450

Query: 568 AGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA 627
               E DL      +  +    Q L +  + +   +  R   + ++   + T    R  A
Sbjct: 451 HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510

Query: 628 --GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDG-AEWGV 679
              +      + Q+ L+  +R        D  +  LQD  L+  VEE Q  +    ++  
Sbjct: 511 LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA 570

Query: 680 DLPSVEAQLGSHRGLHQSIEEF-QAKIERARSDEG--QLSPATRGAYRDCLGRLDLQYAK 736
            LP  + + G+  G+   I++  Q    R  S      LSP       D + +L     +
Sbjct: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630

Query: 737 LLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 771
            L    AR +  E L   F A A     W+  K EE
Sbjct: 631 TLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  243 bits (619), Expect = 1e-63
 Identities = 198/826 (23%), Positives = 370/826 (44%), Gaps = 114/826 (13%)

Query: 527  LQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLF 586
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86

Query: 587  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 646
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133

Query: 647  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIE 706
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183

Query: 707  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 766
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230

Query: 767  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 825
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290

Query: 826  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCD 885
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +K   D
Sbjct: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350

Query: 886  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 945
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLK-PIPVEAL 407

Query: 946  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRL 1005
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP + E       L
Sbjct: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSL 466

Query: 1006 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 1065
             +Q+++                           +R  +  + RTL   +QR  +   E  
Sbjct: 467  GSQYRS---------------------------VRQKAAGSKRTL---QQRYEVLKTENP 496

Query: 1066 YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1125
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528

Query: 1126 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1184
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574

Query: 1185 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1244
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634

Query: 1245 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1304
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694

Query: 1305 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESAD 1350
             ++ER    V +L +R+  +  Q + R + L+       ++    D
Sbjct: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD 740



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 68/264 (25%), Positives = 106/264 (40%), Gaps = 35/264 (13%)

Query: 1112 ESRCQRCISELKDIRLQLEACETRTVHRLRLPL----DKEP---ARECAQRIAEQQKAQA 1164
            E   QR   E+ D    +E C+   +++L+  +    D +P    +E  Q I + Q+   
Sbjct: 1245 EKELQRLREEIVDKTRLIERCDLE-IYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQ 1303

Query: 1165 EVEGLGKGVARLSAEAEKVLALPEP--SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1222
              E +    A+LS E +K + L     S      R E EL+  K   V+     Y E   
Sbjct: 1304 TKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEE--- 1360

Query: 1223 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL---RAQAEAQQPTF 1279
                        E  LRA       A+++   L +++  +A L++L   R + E Q    
Sbjct: 1361 ------------EPGLRAEASAF--AESIDVELRQIDKLRAELRRLQRRRTELERQLEEL 1406

Query: 1280 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ-RELEQL 1338
            +  R   R A+   +RLQQR    + E    RE+V       Q V+ Q D +Q RE   L
Sbjct: 1407 ERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHT----QKVVLQQDPQQAREHALL 1462

Query: 1339 GRQLRYYRESADPLGAWLQDARRR 1362
              QL   +     L   L+  RR+
Sbjct: 1463 RLQLEEEQHRRQLLEGELETLRRK 1486



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 218/1082 (20%), Positives = 396/1082 (36%), Gaps = 244/1082 (22%)

Query: 499  VEKEWGKLHVAILEREKQLRSEFERLE----------CLQRIVTK------LQMEAGLCE 542
            ++K   ++   I++ E +++S+  RL+           LQ+++        L+ +A + +
Sbjct: 34   LQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAK 93

Query: 543  EQLHQADALLQSDIRLLAA------GKVPQRAGEVERDLD-----------KADSMIRLL 585
               H    ++  DIR L        GK  Q      +++D           K D +    
Sbjct: 94   HMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQS 153

Query: 586  FNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI---RTEYNLRLKAGVAAPATQVAQVTLQ 642
            F     L D +  +    +  V  +   L           LR K      A+Q  Q  L 
Sbjct: 154  FGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLS 213

Query: 643  SVQRRPELEDSTLRYLQDLLAWVEEN---QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699
            S+Q         ++   + L W+++    + + D ++  +D PS   Q  +   +++++E
Sbjct: 214  SLQ-------DYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENF--INRNLE 264

Query: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDL------QYAKLLNSSKARLRSLESLHS 753
              + +I +  S+  QL  A           ++       +Y  LL   ++ L+ +E  H 
Sbjct: 265  AKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQ 324

Query: 754  F---VAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKE--- 807
            F   V  A + L  ++    ++ G D+ DR             L+REL+ +EK + +   
Sbjct: 325  FHEDVKDAQELLRKVDSDLNQKYGPDFKDRY--------QIELLLRELDDQEKVLDKYED 376

Query: 808  ----LQNAGDRLL----REDHPARPT-------VESFQAALQTQWSWMLQ---------- 842
                LQ  G +++    R + P +P         E  Q  +   +S+ LQ          
Sbjct: 377  VVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELM 436

Query: 843  -----------LCCCI-----EAHLKENAAYFQFFSDVREAEGQLQKLQ---EALRRKNS 883
                       +C  I     EA    ++   Q+ S  ++A G  + LQ   E L+ +N 
Sbjct: 437  DSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENP 496

Query: 884  CDRSATVTR-----LEDLLQD---------------------AQDEKEQLNEYKGHLSGL 917
             D S    R     L+ +  D                      QD  E+  + K   + L
Sbjct: 497  GDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNEL 556

Query: 918  AK----RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC-QLVGPAQPS-- 970
             +    + ++  + +    A P  G  PLL      +VE T  K +   QL+  AQ    
Sbjct: 557  LRIEPEKTRSTAEGEAFIQALPGSGTTPLLRT----RVEDTNRKYEHLLQLLDLAQEKVD 612

Query: 971  -----------HWKVLSSS----GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTL 1015
                        W++L++       +  VP    ++    QE+      L+AQ   L  +
Sbjct: 613  VANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEV 672

Query: 1016 WHQLHV--DMKSLLAWQSLRRDVQLIRSWSLA-----TFRTLKPEEQR--QALHSLELHY 1066
               L       S LA +       L R  +        F  L+ + +R  Q+L S +  Y
Sbjct: 673  EQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAY 732

Query: 1067 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQS---LEQGAQEESRCQRCISELK 1123
            + F R       F         +E  S S    +L      L++ A  E   Q+  +  +
Sbjct: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQ 792

Query: 1124 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1183
              +  ++  E     +LR  LD E  R  +  ++++ + Q+    + +  A L+A+  +V
Sbjct: 793  QYQQAVKDYELEA-EKLRSLLDLENGR--SSHVSKRARLQSPATKVKEEEAALAAKFTEV 849

Query: 1184 LA-----LPEPSPAAPTLRS--ELELTLGKLEQVRSLSAIY------------LEKLKTI 1224
             A     L     A   LR   E+E+T   L++ R  S +              E+ + +
Sbjct: 850  YAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQL 909

Query: 1225 SLVIRGTQGAEEVLR--------AHEEQLKEA---------QAVPATLPELE----ATKA 1263
               ++ TQ     LR          +E LK+          Q +  TL E +      + 
Sbjct: 910  ENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQE 969

Query: 1264 SLKKLRAQAEA-QQPTFD-----------------ALRDELRGAQEVGERLQQRHGERDV 1305
             L+ L+ Q  A +Q T D                 A  DE+   +E  E L+++ G R+ 
Sbjct: 970  ELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREA 1029

Query: 1306 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1365
            EV   ++RVA L E  +   AQ  V ++E+ +L    +   E        LQ+  +RQ+Q
Sbjct: 1030 EVLLLQQRVAALAE--EKSRAQEKVTEKEVVKLQNDPQLEAEYQQ-----LQEDHQRQDQ 1082

Query: 1366 IQ 1367
            ++
Sbjct: 1083 LR 1084



 Score = 33.1 bits (74), Expect = 1.9
 Identities = 49/253 (19%), Positives = 113/253 (44%), Gaps = 22/253 (8%)

Query: 500  EKEWGKLHVAILEREK-------QLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALL 552
            E E   L + ++E+E+       QLRS    LE L+R   +++++    E   ++ D  +
Sbjct: 1185 ESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEM 1244

Query: 553  QSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR-HPQGEQMYRRVYRLH 611
            + +++     ++ +   +  R +++ D  I  L  ++Q LKD +   Q +++ + + +  
Sbjct: 1245 EKELQ-----RLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQ 1299

Query: 612  ------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYL-QDLLAW 664
                  E + ++R + +   K  V     + +Q   Q  ++  EL     R + Q+++ +
Sbjct: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQEE-QIARKEEELSRVKERVVQQEVVRY 1358

Query: 665  VEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYR 724
             EE   R + + +   +     Q+   R   + ++  + ++ER   +  +   A R A R
Sbjct: 1359 EEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAER 1418

Query: 725  DCLGRLDLQYAKL 737
            + + RL  + A L
Sbjct: 1419 E-VQRLQQRLAAL 1430



 Score = 32.0 bits (71), Expect = 4.2
 Identities = 53/215 (24%), Positives = 81/215 (37%), Gaps = 52/215 (24%)

Query: 1084 RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP 1143
            R  AERE        Q+L Q L    QEE+  +  ++  + + LQ +  + R    LRL 
Sbjct: 1413 RREAEREV-------QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQ 1465

Query: 1144 LDKEPARECAQRIAEQQKAQAEVEGLGKGVARL-SAEAEKVLALPEPSPAAPTLRSELEL 1202
            L++E  R        +Q  + E+E L + +A L  AE ++ + L E              
Sbjct: 1466 LEEEQHR--------RQLLEGELETLRRKLAALEKAEVKEKVVLSE-------------- 1503

Query: 1203 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1262
                        ++ +EK  T   + R     EE  R+  E   E   + A L ELE   
Sbjct: 1504 ------------SVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHN 1551

Query: 1263 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1297
            +   K            D LR+E    Q   + LQ
Sbjct: 1552 SKSSK----------ELDFLREENHKLQLERQNLQ 1576



 Score = 31.2 bits (69), Expect = 7.1
 Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 14/88 (15%)

Query: 511  LEREKQLRSEFER--LECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRA 568
            LERE+Q R E ER      QR+    Q EA   E+  H    +LQ D         PQ+A
Sbjct: 1406 LERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQD---------PQQA 1456

Query: 569  GE---VERDLDKADSMIRLLFNDVQTLK 593
             E   +   L++     +LL  +++TL+
Sbjct: 1457 REHALLRLQLEEEQHRRQLLEGELETLR 1484



 Score = 30.8 bits (68), Expect = 9.3
 Identities = 82/405 (20%), Positives = 167/405 (41%), Gaps = 35/405 (8%)

Query: 995  NQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1054
            NQ  QE+V R E   +    +  +    ++  LA +  +   QL++    A    L+  E
Sbjct: 925  NQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKN--QLLQEELEALQLQLRALE 982

Query: 1055 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE-----REYGSCSHHYQQLLQSLEQGA 1109
            Q       E   +  LR   D        +L  E     R+ G+       L Q +   A
Sbjct: 983  QETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALA 1042

Query: 1110 QEESRCQRCISELKDIRLQ------LEACETRTVHRLRLPLDKEPARECA-----QRIAE 1158
            +E+SR Q  ++E + ++LQ       E  + +  H+ +  L ++   E +      +  E
Sbjct: 1043 EEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLE 1102

Query: 1159 QQKAQAEVEGLGKGVARLSAEAEKVLAL--------PEPSPAAPTLRSELELTLGKLEQV 1210
            +++A AE +   K V ++  +A     +         E + A  + R + EL L K+  +
Sbjct: 1103 KERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTEL-LRKIWAL 1161

Query: 1211 RSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR- 1269
               +A  + + K   +V    +   EV     E +++ +       +L + ++ L+ LR 
Sbjct: 1162 EEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRR 1221

Query: 1270 --AQAEAQQPTFDALRDELRGAQEVG-ERLQQRHGERDVEVERWRERVAQLLERWQAVL- 1325
               Q E ++ T + ++ +     E   +RL++   ++   +ER    + QL +  QA+  
Sbjct: 1222 RGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKD 1281

Query: 1326 AQTDVRQRELEQLGRQLR---YYRESADPLGAWLQDARRRQEQIQ 1367
             +  V+ +E+ Q   Q +     +E    L A L + +++Q  ++
Sbjct: 1282 TKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLE 1326


>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
          Length = 887

 Score =  238 bits (607), Expect = 3e-62
 Identities = 146/396 (36%), Positives = 216/396 (54%), Gaps = 23/396 (5%)

Query: 174 DRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 232
           ++ Q+KT T W N HL KA   I ++ ED RDG  L+ LLEV+SG+ L + E+G+MR HK
Sbjct: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89

Query: 233 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 292
           + NV  ALD++  + VKLV+I  ++I DGN K+TLG+IWTIIL F I DI V    E+ +
Sbjct: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV----EETS 145

Query: 293 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 352
           AKE LLLW QR    Y+ +   NF  SW+DG  F A+IHRH+P LID  K+ +   L NL
Sbjct: 146 AKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL 205

Query: 353 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 407
           + AF VAE+ L + ++LD ED V   +PDEK+I+TYVSS Y A       +         
Sbjct: 206 NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 265

Query: 408 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 463
                E +   ++Y +L   LL+W+R      E R   ++   ++     F  ++ +  P
Sbjct: 266 LAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKP 325

Query: 464 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 517
            K  +K + +  + +L+  +   +L   P + P       D+   WG L       E+ L
Sbjct: 326 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWL 382

Query: 518 RSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQ 553
            +E  RLE L  +  K + +A + E      +A+L+
Sbjct: 383 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLR 418


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.132    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 52,894,542
Number of Sequences: 37866
Number of extensions: 2504807
Number of successful extensions: 13811
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 140
Number of HSP's successfully gapped in prelim test: 397
Number of HSP's that attempted gapping in prelim test: 10589
Number of HSP's gapped (non-prelim): 2885
length of query: 1369
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1254
effective length of database: 13,892,928
effective search space: 17421731712
effective search space used: 17421731712
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.