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Search of human proteins with 169215813
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169215813 PREDICTED: preferentially expressed antigen in
melanoma-like [Homo sapiens]
(520 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169216010 PREDICTED: preferentially expressed antigen in mela... 1053 0.0
gi|169215813 PREDICTED: preferentially expressed antigen in mela... 1053 0.0
gi|239746677 PREDICTED: preferentially expressed antigen in mela... 1050 0.0
gi|153792112 PRAME family member 20 [Homo sapiens] 231 1e-60
gi|153945800 PRAME family member 21 [Homo sapiens] 231 1e-60
gi|124249372 PRAME family member 12 [Homo sapiens] 226 5e-59
gi|239741053 PREDICTED: similar to Putative PRAME family member ... 223 4e-58
gi|59676587 PRAME family member 8 [Homo sapiens] 222 6e-58
gi|59676593 PRAME family member 7 [Homo sapiens] 220 3e-57
gi|46249373 preferentially expressed antigen in melanoma [Homo s... 219 6e-57
gi|46249371 preferentially expressed antigen in melanoma [Homo s... 219 6e-57
gi|46249369 preferentially expressed antigen in melanoma [Homo s... 219 6e-57
gi|46249367 preferentially expressed antigen in melanoma [Homo s... 219 6e-57
gi|5174641 preferentially expressed antigen in melanoma [Homo sa... 219 6e-57
gi|239741043 PREDICTED: PRAME family member 11 [Homo sapiens] 214 2e-55
gi|58219004 PRAME family member 6 [Homo sapiens] 214 2e-55
gi|61696142 PRAME family member 5 [Homo sapiens] 212 6e-55
gi|148356236 PRAME family member 15 [Homo sapiens] 211 1e-54
gi|61102721 PRAME family member 9 [Homo sapiens] 211 1e-54
gi|239741047 PREDICTED: PRAME family member 25-like [Homo sapiens] 209 5e-54
gi|239741045 PREDICTED: PRAME family member 23 [Homo sapiens] 208 1e-53
gi|59958373 PRAME family member 4 [Homo sapiens] 207 2e-53
gi|226437621 PRAME family member 11 [Homo sapiens] 185 1e-46
gi|157426839 PRAME family member 17 [Homo sapiens] 182 8e-46
gi|113865933 PRAME family member 16 [Homo sapiens] 181 1e-45
gi|154800493 PRAME family member 22 [Homo sapiens] 174 2e-43
gi|194306638 PRAME family member 3 [Homo sapiens] 174 2e-43
gi|7661860 leucine rich repeat containing 14 [Homo sapiens] 171 1e-42
gi|194018546 PRAME family member 10 [Homo sapiens] 169 4e-42
gi|12738831 PRAME family member 1 [Homo sapiens] 167 3e-41
>gi|169216010 PREDICTED: preferentially expressed antigen in
melanoma-like [Homo sapiens]
Length = 520
Score = 1053 bits (2723), Expect = 0.0
Identities = 520/520 (100%), Positives = 520/520 (100%)
Query: 1 MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60
MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM
Sbjct: 1 MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60
Query: 61 EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120
EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW
Sbjct: 61 EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120
Query: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180
PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG
Sbjct: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180
Query: 181 ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240
ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM
Sbjct: 181 ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240
Query: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF 300
AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF
Sbjct: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF 300
Query: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360
SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD
Sbjct: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360
Query: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420
ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL
Sbjct: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420
Query: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480
LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP
Sbjct: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480
Query: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520
VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV
Sbjct: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520
>gi|169215813 PREDICTED: preferentially expressed antigen in
melanoma-like [Homo sapiens]
Length = 520
Score = 1053 bits (2723), Expect = 0.0
Identities = 520/520 (100%), Positives = 520/520 (100%)
Query: 1 MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60
MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM
Sbjct: 1 MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60
Query: 61 EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120
EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW
Sbjct: 61 EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120
Query: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180
PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG
Sbjct: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180
Query: 181 ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240
ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM
Sbjct: 181 ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240
Query: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF 300
AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF
Sbjct: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF 300
Query: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360
SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD
Sbjct: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360
Query: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420
ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL
Sbjct: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420
Query: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480
LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP
Sbjct: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480
Query: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520
VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV
Sbjct: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520
>gi|239746677 PREDICTED: preferentially expressed antigen in
melanoma-like [Homo sapiens]
Length = 520
Score = 1050 bits (2715), Expect = 0.0
Identities = 518/520 (99%), Positives = 518/520 (99%)
Query: 1 MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60
MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM
Sbjct: 1 MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60
Query: 61 EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120
EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW
Sbjct: 61 EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120
Query: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180
PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG
Sbjct: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180
Query: 181 ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240
ASEAL KFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM
Sbjct: 181 ASEALTKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240
Query: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF 300
AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRS KLFYYKWAF
Sbjct: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSFKLFYYKWAF 300
Query: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360
SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD
Sbjct: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360
Query: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420
ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL
Sbjct: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420
Query: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480
LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP
Sbjct: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480
Query: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520
VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV
Sbjct: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520
>gi|153792112 PRAME family member 20 [Homo sapiens]
Length = 475
Score = 231 bits (589), Expect = 1e-60
Identities = 172/459 (37%), Positives = 248/459 (54%), Gaps = 37/459 (8%)
Query: 67 PLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLH 126
P LLELA SLL +EA LE+L LFPPL AF++ H +ALK +VQAWPF L
Sbjct: 6 PPRLLELAGRSLLRDEALAISTLEELPTELFPPLFMEAFSRRHCEALKLMVQAWPFLRLP 65
Query: 127 LGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEALA 186
LGSL+ + P ++ QAV+DGL+A HR R+ +L++LD SE + SEA+A
Sbjct: 66 LGSLMKR-PCPETFQAVLDGLDALLTHRVRLRRWKLQVLDLQDVSENFWMVW---SEAMA 121
Query: 187 KFPFWLPSAVKAETP-----------------QATARPKPLDKFLSDLLTKVEQSHGALH 229
+ LP+A+ P + + LD++ + L V+Q G +H
Sbjct: 122 RR--CLPNAMMNRKPVQDCPRMRGQQPLTVFIDLCLKNRTLDEYFTCLFLWVKQREGLVH 179
Query: 230 LCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLGRIFNL 288
LCC+KL + M ++ ILKT+ LD IQE+EV W L P LG++ NL
Sbjct: 180 LCCKKLKMLGMLFHNIRNILKTVNLDCIQEVEVNCNWTLPVLAEFTP-----YLGQMRNL 234
Query: 289 RSLKLFYYKWAFSSWVRRPS--SYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVP 345
R L L + S ++ + F +Q L L+KL++ S S+L G L +LSCL
Sbjct: 235 RKLVLSDIDSRYISPEQKKEFVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQMLSCLKTS 294
Query: 346 LHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHL 405
L+ L I NC LL++D+ +LS+ LK LDLS L+ PL LL V+ TL++L
Sbjct: 295 LNILAITNCVLLESDLKHLSKYPSIGQLKTLDLSGTRLANFSLVPLQVLLEKVAATLEYL 354
Query: 406 DLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPI 465
DL C + D+ ++A+LPAL RC L++ S NPIS+A L +LL HT+ L L LYP
Sbjct: 355 DLDDCGIVDSQVNAILPALSRCFELTTFSFRGNPISTATLENLLCHTIRLNNLCLELYPA 414
Query: 466 PVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQAD 504
P + VCR + QL AE+ +++A+++ +
Sbjct: 415 PRESYDVRGIVCR-----SRFAQLGAELMGRVRALREPE 448
>gi|153945800 PRAME family member 21 [Homo sapiens]
Length = 475
Score = 231 bits (589), Expect = 1e-60
Identities = 172/459 (37%), Positives = 248/459 (54%), Gaps = 37/459 (8%)
Query: 67 PLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLH 126
P LLELA SLL +EA LE+L LFPPL AF++ H +ALK +VQAWPF L
Sbjct: 6 PPRLLELAGRSLLRDEALAISTLEELPTELFPPLFMEAFSRRHCEALKLMVQAWPFLRLP 65
Query: 127 LGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEALA 186
LGSL+ + P ++ QAV+DGL+A HR R+ +L++LD SE + SEA+A
Sbjct: 66 LGSLMKR-PCPETFQAVLDGLDALLTHRVRLRRWKLQVLDLQDVSENFWMVW---SEAMA 121
Query: 187 KFPFWLPSAVKAETP-----------------QATARPKPLDKFLSDLLTKVEQSHGALH 229
+ LP+A+ P + + LD++ + L V+Q G +H
Sbjct: 122 RR--CLPNAMMNRKPVQDCPRMRGQQPLTVFIDLCLKNRTLDEYFTCLFLWVKQREGLVH 179
Query: 230 LCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLGRIFNL 288
LCC+KL + M ++ ILKT+ LD IQE+EV W L P LG++ NL
Sbjct: 180 LCCKKLKMLGMLFHNIRNILKTVNLDCIQEVEVNCNWTLPVLAEFTP-----YLGQMRNL 234
Query: 289 RSLKLFYYKWAFSSWVRRPS--SYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVP 345
R L L + S ++ + F +Q L L+KL++ S S+L G L +LSCL
Sbjct: 235 RKLVLSDIDSRYISPEQKKEFVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQMLSCLKTS 294
Query: 346 LHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHL 405
L+ L I NC LL++D+ +LS+ LK LDLS L+ PL LL V+ TL++L
Sbjct: 295 LNILAITNCVLLESDLKHLSKYPSIGQLKTLDLSGTRLANFSLVPLQVLLEKVAATLEYL 354
Query: 406 DLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPI 465
DL C + D+ ++A+LPAL RC L++ S NPIS+A L +LL HT+ L L LYP
Sbjct: 355 DLDDCGIVDSQVNAILPALSRCFELTTFSFRGNPISTATLENLLCHTIRLNNLCLELYPA 414
Query: 466 PVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQAD 504
P + VCR + QL AE+ +++A+++ +
Sbjct: 415 PRESYDVRGIVCR-----SRFAQLGAELMGRVRALREPE 448
>gi|124249372 PRAME family member 12 [Homo sapiens]
Length = 483
Score = 226 bits (575), Expect = 5e-59
Identities = 170/459 (37%), Positives = 241/459 (52%), Gaps = 40/459 (8%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
AP LLELA SLL + A LE+L LFPPL AF + + L +VQAWPF L
Sbjct: 5 APPRLLELAEQSLLRDRALAIPTLEELPRELFPPLFMEAFTRRCCETLTTMVQAWPFTCL 64
Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
LGSL+ N + +AV++GL+A A + PR+ +L++LD E + GAS AL
Sbjct: 65 PLGSLMKSC-NLEIFRAVLEGLDALLAQKVRPRRWKLQVLDLRNVDENFWGIWSGAS-AL 122
Query: 186 AKFPFWLPSAV-KAETPQATARP---KPL-------------DKFLSDLLTKVEQSHGAL 228
+ P A+ K T RP +PL D+ L+ L +Q G L
Sbjct: 123 S------PEALSKRRTAGNCPRPGGQQPLMVILDLCFKNGMLDECLTHFLEWGKQRKGLL 176
Query: 229 HLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAIQLGRIFN 287
H+CC++L I +A+ ++ +L T+ LD IQE+EV W L+ P LG++ N
Sbjct: 177 HVCCKELQIFGIAIHRIIEVLNTVELDCIQEVEVCCPWELSILIRFAP-----YLGQMRN 231
Query: 288 LRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLW 343
LR L LF + + R + F SQ L + +KL++ S S+L G L +L CL
Sbjct: 232 LRKLVLFNIHVSACIPLDRKEQFVIQFTSQFLKLDYFQKLYMHSVSFLEGHLDQLLRCLQ 291
Query: 344 VPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQ 403
PL ++ + C L ++D+ +LS LK+LDL L++ P PL LL TLQ
Sbjct: 292 APLETVVMTECLLSESDLKHLSWCPSIRQLKELDLRGITLTHFSPEPLSVLLEQAEATLQ 351
Query: 404 HLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLY 463
LDL+ C + D+ LSA+LPAL RCS LS+ S N IS A L +LL HT+GL +L LY
Sbjct: 352 TLDLEDCGIVDSQLSAILPALSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELY 411
Query: 464 PIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
P P++ +C G + QL AE+ K L+ ++Q
Sbjct: 412 PAPLESYDAQGALCWG-----RFSQLGAELMKTLRDLRQ 445
>gi|239741053 PREDICTED: similar to Putative PRAME family member 24
[Homo sapiens]
Length = 474
Score = 223 bits (567), Expect = 4e-58
Identities = 162/455 (35%), Positives = 236/455 (51%), Gaps = 32/455 (7%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
AP LLELA LL ++A +E+L LFP L AF++ + LK +VQAWPF L
Sbjct: 5 APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64
Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
LGSL+ P+ +SL++V++G++ PR+S+L++LD E GA+
Sbjct: 65 PLGSLMKS-PHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT--- 120
Query: 186 AKFPFWLPSAVKAETPQATARPKP-------------LDKFLSDLLTKVEQSHGALHLCC 232
A FP L A+ T R +P LD+ L+ LL +Q G LH+CC
Sbjct: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180
Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAIQLGRIFNLRSL 291
++L + M + S++ +L + LD IQE+EV W LV P LG++ NLR L
Sbjct: 181 KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAP-----YLGQMRNLRKL 235
Query: 292 KLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPLH 347
LF + + + F SQ L + + L + S S+L G L +L CL L
Sbjct: 236 VLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLE 295
Query: 348 SLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDL 407
+ + +C L ++D+ +LS LK+LDL L++ P PL LL V TLQ LDL
Sbjct: 296 MVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDL 355
Query: 408 KHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPV 467
+ C + D+ LSA+LP L RCS LS+ S N IS A L +LL HT+GL +L LYP P+
Sbjct: 356 EDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPL 415
Query: 468 DCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
+ +C G + +L AE+ K L+ ++Q
Sbjct: 416 ESYDTQGALCWG-----RFAELGAELMKTLRDLRQ 445
>gi|59676587 PRAME family member 8 [Homo sapiens]
Length = 474
Score = 222 bits (566), Expect = 6e-58
Identities = 162/455 (35%), Positives = 236/455 (51%), Gaps = 32/455 (7%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
AP LLELA LL ++A +E+L LFP L AF++ + LK +VQAWPF L
Sbjct: 5 APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64
Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
LGSL+ P+ +SL++V++G++ PR+S+L++LD E GA+
Sbjct: 65 PLGSLMKS-PHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT--- 120
Query: 186 AKFPFWLPSAVKAETPQATARPKP-------------LDKFLSDLLTKVEQSHGALHLCC 232
A FP L A+ T R +P LD+ L+ LL +Q G LH+CC
Sbjct: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180
Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAIQLGRIFNLRSL 291
++L + M + S++ +L + LD IQE+EV W LV P LG++ NLR L
Sbjct: 181 QELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAP-----YLGQMRNLRKL 235
Query: 292 KLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPLH 347
LF + + + F SQ L + + L + S S+L G L +L CL L
Sbjct: 236 VLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLE 295
Query: 348 SLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDL 407
+ + +C L ++D+ +LS LK+LDL L++ P PL LL V TLQ LDL
Sbjct: 296 MVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDL 355
Query: 408 KHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPV 467
+ C + D+ LSA+LP L RCS LS+ S N IS A L +LL HT+GL +L LYP P+
Sbjct: 356 EDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPL 415
Query: 468 DCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
+ +C G + +L AE+ K L+ ++Q
Sbjct: 416 ESYDTQGALCWG-----RFAELGAELMKTLRDLRQ 445
>gi|59676593 PRAME family member 7 [Homo sapiens]
Length = 474
Score = 220 bits (560), Expect = 3e-57
Identities = 161/455 (35%), Positives = 235/455 (51%), Gaps = 32/455 (7%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
AP LLELA LL ++A +E+L LFP L AF++ + LK +VQAWPF L
Sbjct: 5 APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64
Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
LGSL+ P+ +SL++V++G++ PR+S+L++LD E GA+
Sbjct: 65 PLGSLMKS-PHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT--- 120
Query: 186 AKFPFWLPSAVKAETPQATARPKP-------------LDKFLSDLLTKVEQSHGALHLCC 232
A FP L A+ T R +P LD+ L+ LL +Q G LH+CC
Sbjct: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180
Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAIQLGRIFNLRSL 291
++L + M + S++ +L + LD IQE+EV W LV P LG++ NLR L
Sbjct: 181 KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAP-----YLGQMRNLRKL 235
Query: 292 KLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPLH 347
LF + + + F SQ L + + L + S S+L G L +L CL L
Sbjct: 236 VLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLE 295
Query: 348 SLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDL 407
+ + +C L ++D+ +LS LK+LDL L++ P PL LL V TLQ LDL
Sbjct: 296 MVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDL 355
Query: 408 KHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPV 467
+ C + D+ LSA+LP L RCS LS+ S N IS A L +LL HT+GL +L LYP P+
Sbjct: 356 EDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPL 415
Query: 468 DCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
+ +C G + +L AE+ K + ++Q
Sbjct: 416 ESYDTQGALCWG-----RFAELGAELMKTPRDLRQ 445
>gi|46249373 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 219 bits (557), Expect = 6e-57
Identities = 166/471 (35%), Positives = 241/471 (51%), Gaps = 40/471 (8%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
+P L+ELA SLL +EA LE L LFPPL AAF H + LKA+VQAWPF L
Sbjct: 22 SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81
Query: 126 HLGSLIV-QWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC-GKGASE 183
LG L+ Q + ++ +AV+DGL+ A PR+ +L++LD +S Q F+ G
Sbjct: 82 PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141
Query: 184 ALAKFPFWLPSAVKAETPQ------ATARPKPL----------------DKFLSDLLTKV 221
+L FP P A + T + +T +P D+ S L+ KV
Sbjct: 142 SLYSFPE--PEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKV 199
Query: 222 EQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAI 280
++ L LCC+KL I M + + ILK ++LD I++LEV W L P
Sbjct: 200 KRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP----- 254
Query: 281 QLGRIFNLRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLH 336
LG++ NLR L L + + + Y F SQ L L+ L++ S +L G+L
Sbjct: 255 YLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLD 314
Query: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
+L + PL +L I NC+L + D+ +LS+S + L L LS L+ + P PL LL
Sbjct: 315 QLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLE 374
Query: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
S TLQ L C + D L ALLP+L CS L++LS N IS + L SLL+H +GL
Sbjct: 375 RASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLS 434
Query: 457 ELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQADMQW 507
L VLYP+P++ +HG ++ ++L L A +++ L + + M W
Sbjct: 435 NLTHVLYPVPLESYEDIHGT----LHLERLAYLHARLRELLCELGRPSMVW 481
>gi|46249371 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 219 bits (557), Expect = 6e-57
Identities = 166/471 (35%), Positives = 241/471 (51%), Gaps = 40/471 (8%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
+P L+ELA SLL +EA LE L LFPPL AAF H + LKA+VQAWPF L
Sbjct: 22 SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81
Query: 126 HLGSLIV-QWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC-GKGASE 183
LG L+ Q + ++ +AV+DGL+ A PR+ +L++LD +S Q F+ G
Sbjct: 82 PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141
Query: 184 ALAKFPFWLPSAVKAETPQ------ATARPKPL----------------DKFLSDLLTKV 221
+L FP P A + T + +T +P D+ S L+ KV
Sbjct: 142 SLYSFPE--PEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKV 199
Query: 222 EQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAI 280
++ L LCC+KL I M + + ILK ++LD I++LEV W L P
Sbjct: 200 KRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP----- 254
Query: 281 QLGRIFNLRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLH 336
LG++ NLR L L + + + Y F SQ L L+ L++ S +L G+L
Sbjct: 255 YLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLD 314
Query: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
+L + PL +L I NC+L + D+ +LS+S + L L LS L+ + P PL LL
Sbjct: 315 QLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLE 374
Query: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
S TLQ L C + D L ALLP+L CS L++LS N IS + L SLL+H +GL
Sbjct: 375 RASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLS 434
Query: 457 ELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQADMQW 507
L VLYP+P++ +HG ++ ++L L A +++ L + + M W
Sbjct: 435 NLTHVLYPVPLESYEDIHGT----LHLERLAYLHARLRELLCELGRPSMVW 481
>gi|46249369 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 219 bits (557), Expect = 6e-57
Identities = 166/471 (35%), Positives = 241/471 (51%), Gaps = 40/471 (8%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
+P L+ELA SLL +EA LE L LFPPL AAF H + LKA+VQAWPF L
Sbjct: 22 SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81
Query: 126 HLGSLIV-QWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC-GKGASE 183
LG L+ Q + ++ +AV+DGL+ A PR+ +L++LD +S Q F+ G
Sbjct: 82 PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141
Query: 184 ALAKFPFWLPSAVKAETPQ------ATARPKPL----------------DKFLSDLLTKV 221
+L FP P A + T + +T +P D+ S L+ KV
Sbjct: 142 SLYSFPE--PEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKV 199
Query: 222 EQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAI 280
++ L LCC+KL I M + + ILK ++LD I++LEV W L P
Sbjct: 200 KRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP----- 254
Query: 281 QLGRIFNLRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLH 336
LG++ NLR L L + + + Y F SQ L L+ L++ S +L G+L
Sbjct: 255 YLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLD 314
Query: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
+L + PL +L I NC+L + D+ +LS+S + L L LS L+ + P PL LL
Sbjct: 315 QLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLE 374
Query: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
S TLQ L C + D L ALLP+L CS L++LS N IS + L SLL+H +GL
Sbjct: 375 RASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLS 434
Query: 457 ELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQADMQW 507
L VLYP+P++ +HG ++ ++L L A +++ L + + M W
Sbjct: 435 NLTHVLYPVPLESYEDIHGT----LHLERLAYLHARLRELLCELGRPSMVW 481
>gi|46249367 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 219 bits (557), Expect = 6e-57
Identities = 166/471 (35%), Positives = 241/471 (51%), Gaps = 40/471 (8%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
+P L+ELA SLL +EA LE L LFPPL AAF H + LKA+VQAWPF L
Sbjct: 22 SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81
Query: 126 HLGSLIV-QWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC-GKGASE 183
LG L+ Q + ++ +AV+DGL+ A PR+ +L++LD +S Q F+ G
Sbjct: 82 PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141
Query: 184 ALAKFPFWLPSAVKAETPQ------ATARPKPL----------------DKFLSDLLTKV 221
+L FP P A + T + +T +P D+ S L+ KV
Sbjct: 142 SLYSFPE--PEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKV 199
Query: 222 EQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAI 280
++ L LCC+KL I M + + ILK ++LD I++LEV W L P
Sbjct: 200 KRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP----- 254
Query: 281 QLGRIFNLRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLH 336
LG++ NLR L L + + + Y F SQ L L+ L++ S +L G+L
Sbjct: 255 YLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLD 314
Query: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
+L + PL +L I NC+L + D+ +LS+S + L L LS L+ + P PL LL
Sbjct: 315 QLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLE 374
Query: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
S TLQ L C + D L ALLP+L CS L++LS N IS + L SLL+H +GL
Sbjct: 375 RASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLS 434
Query: 457 ELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQADMQW 507
L VLYP+P++ +HG ++ ++L L A +++ L + + M W
Sbjct: 435 NLTHVLYPVPLESYEDIHGT----LHLERLAYLHARLRELLCELGRPSMVW 481
>gi|5174641 preferentially expressed antigen in melanoma [Homo
sapiens]
Length = 509
Score = 219 bits (557), Expect = 6e-57
Identities = 166/471 (35%), Positives = 241/471 (51%), Gaps = 40/471 (8%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
+P L+ELA SLL +EA LE L LFPPL AAF H + LKA+VQAWPF L
Sbjct: 22 SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81
Query: 126 HLGSLIV-QWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC-GKGASE 183
LG L+ Q + ++ +AV+DGL+ A PR+ +L++LD +S Q F+ G
Sbjct: 82 PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141
Query: 184 ALAKFPFWLPSAVKAETPQ------ATARPKPL----------------DKFLSDLLTKV 221
+L FP P A + T + +T +P D+ S L+ KV
Sbjct: 142 SLYSFPE--PEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKV 199
Query: 222 EQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAI 280
++ L LCC+KL I M + + ILK ++LD I++LEV W L P
Sbjct: 200 KRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP----- 254
Query: 281 QLGRIFNLRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLH 336
LG++ NLR L L + + + Y F SQ L L+ L++ S +L G+L
Sbjct: 255 YLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLD 314
Query: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
+L + PL +L I NC+L + D+ +LS+S + L L LS L+ + P PL LL
Sbjct: 315 QLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLE 374
Query: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
S TLQ L C + D L ALLP+L CS L++LS N IS + L SLL+H +GL
Sbjct: 375 RASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLS 434
Query: 457 ELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQADMQW 507
L VLYP+P++ +HG ++ ++L L A +++ L + + M W
Sbjct: 435 NLTHVLYPVPLESYEDIHGT----LHLERLAYLHARLRELLCELGRPSMVW 481
>gi|239741043 PREDICTED: PRAME family member 11 [Homo sapiens]
Length = 513
Score = 214 bits (545), Expect = 2e-55
Identities = 166/466 (35%), Positives = 246/466 (52%), Gaps = 38/466 (8%)
Query: 58 RSMEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALV 117
R M+++ P LLEL SLL ++A LE+L LFPPL AF++ +ALK +V
Sbjct: 34 RFMKMSIRIPPRLLELXGRSLLRDQALAVSTLEELPTELFPPLFMEAFSRRRCEALKLMV 93
Query: 118 QAWPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC 177
QAWPFR L L LI + P ++ QAV+DGL+A PR+ +L++LD E +
Sbjct: 94 QAWPFRRLPLRPLI-KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDVCENFWMV 152
Query: 178 GKGASEALAKFPFWLPSAVKAETP-----------------QATARPKPLDKFLSDLLTK 220
SEA+A F +A + +TP + + + LD++L+ LL
Sbjct: 153 W---SEAMAHGCFL--NAKRNKTPVQDCPRMRERQPLTVFVELWLKNRTLDEYLTCLLLW 207
Query: 221 VEQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSA 279
V+Q LHLCC+KL I M ++ ILK + LD IQE+EV W L P
Sbjct: 208 VKQRRDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWILPILTQFTP---- 263
Query: 280 IQLGRIFNLRSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKL 335
LG + NL+ L L + ++ + + F +Q L L+KL++ S S+L G L
Sbjct: 264 -YLGHLRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHL 322
Query: 336 HYILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLL 395
+LSCL L L I NC LL++D+ +LS+ + LK LDLS L+ PL LL
Sbjct: 323 DQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILL 382
Query: 396 RAVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGL 455
V+ TL++LDL C + D+ ++A+LPAL RC L++ S NPI A L +LL HT+ L
Sbjct: 383 EKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIIL 442
Query: 456 MELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
L LYP P + +G G + + Q++AE+ K+++ ++
Sbjct: 443 KNLCLELYPAPQES----YG-ADGTLCWSRFAQIRAELMKKVRHLR 483
>gi|58219004 PRAME family member 6 [Homo sapiens]
Length = 476
Score = 214 bits (544), Expect = 2e-55
Identities = 165/457 (36%), Positives = 241/457 (52%), Gaps = 38/457 (8%)
Query: 67 PLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLH 126
P LLELA SLL ++A LE+L LFPPL AF++ +ALK +VQAWPFR L
Sbjct: 6 PPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLP 65
Query: 127 LGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEALA 186
L LI + P ++ QAV+DGL+A PR+ +L++LD E + SEA+A
Sbjct: 66 LRPLI-KMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVW---SEAMA 121
Query: 187 KFPFWLPSAVKAETP-----------------QATARPKPLDKFLSDLLTKVEQSHGALH 229
+ F +A + +TP + + + LD++L+ LL V+Q LH
Sbjct: 122 RGCFL--NAKRNKTPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLH 179
Query: 230 LCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLGRIFNL 288
LCC+KL I M ++ ILK + LD IQE+EV W L P LG + NL
Sbjct: 180 LCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLGHMRNL 234
Query: 289 RSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWV 344
+ L L + ++ + + F +Q L L+KL + S S+L G L +LSCL
Sbjct: 235 QKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKT 294
Query: 345 PLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQH 404
L L I NC LL++D+ +LS+ + LK LDLS L+ PL LL V+ TL++
Sbjct: 295 SLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEY 354
Query: 405 LDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYP 464
LDL C + D+ ++A+LPAL RC L++ S NPIS A L +LL HT+ L L LYP
Sbjct: 355 LDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYP 414
Query: 465 IPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
P + G + + Q++AE+ K+++ ++
Sbjct: 415 APRESY-----DADGTLCWSRFAQIRAELMKRVRDLR 446
>gi|61696142 PRAME family member 5 [Homo sapiens]
Length = 476
Score = 212 bits (540), Expect = 6e-55
Identities = 164/455 (36%), Positives = 239/455 (52%), Gaps = 34/455 (7%)
Query: 67 PLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLH 126
P LLELA SLL ++A LE+L LFPPL AF++ +ALK +VQAWPFR L
Sbjct: 6 PPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLP 65
Query: 127 LGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEALA 186
L LI + P ++ QAV+DGL+A PR+ +L++LD E + SEA+A
Sbjct: 66 LRPLI-KMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVW---SEAMA 121
Query: 187 ----------KFPFWLPSAVKAETP-----QATARPKPLDKFLSDLLTKVEQSHGALHLC 231
K P ++ + P + + + LD++L+ LL V+Q LHLC
Sbjct: 122 HGCFLNAKRNKKPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHLC 181
Query: 232 CRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLGRIFNLRS 290
C+KL I M ++ ILK + LD IQE+EV W L P LG + NL+
Sbjct: 182 CKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLGHMRNLQK 236
Query: 291 LKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPL 346
L L + ++ + + F +Q L L+KL + S S+L G L +LSCL L
Sbjct: 237 LVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSL 296
Query: 347 HSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLD 406
L I NC LL++D+ +LS+ + LK LDLS L+ PL LL V+ TL++LD
Sbjct: 297 KVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLD 356
Query: 407 LKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIP 466
L C + D+ ++A+LPAL RC L++ S NPIS A L +LL HT+ L L LYP P
Sbjct: 357 LDDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYPAP 416
Query: 467 VDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
+ G + + Q++AE+ K+++ ++
Sbjct: 417 RESY-----DADGTLCWSRFAQIRAELMKRVRDLR 446
>gi|148356236 PRAME family member 15 [Homo sapiens]
Length = 478
Score = 211 bits (537), Expect = 1e-54
Identities = 165/462 (35%), Positives = 242/462 (52%), Gaps = 34/462 (7%)
Query: 60 MEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQA 119
M+++ P LLELA SLL ++A LE+L LFPPL AF++ +ALK +VQA
Sbjct: 1 MKMSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQA 60
Query: 120 WPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGK 179
WPFR L L LI + P ++ QAV+DGL+A PR+ +L++LD E +
Sbjct: 61 WPFRRLPLRPLI-KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDVCENFWMVW- 118
Query: 180 GASEALAKFPFWLPSAVKA---ETPQATARP------------KPLDKFLSDLLTKVEQS 224
SEA+A F K + P+ R + LD++L+ LL V+Q
Sbjct: 119 --SEAMAHGCFLNAKRNKKPVQDCPRMRGRQPLTVFVELWLKNRTLDEYLTYLLLWVKQR 176
Query: 225 HGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLG 283
LHLCC+KL I M ++ ILK + LD IQE+EV W L P LG
Sbjct: 177 KDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLG 231
Query: 284 RIFNLRSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYIL 339
+ NL+ L L + ++ + + F +Q L L+KL++ S S+L G L +L
Sbjct: 232 HMRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLL 291
Query: 340 SCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVS 399
SCL L L I NC LL++D+ +LS+ + LK LDLS L+ PL LL V+
Sbjct: 292 SCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVA 351
Query: 400 GTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELK 459
TL++LDL C + D+ ++A+LPAL RC L++ S NPI A L +LL HT+ L L
Sbjct: 352 ATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLC 411
Query: 460 QVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
LYP P + +G G + + Q++AE+ +++ ++
Sbjct: 412 VELYPAPRES----YG-ADGTLCWSRFAQIRAELMNRVRDLR 448
>gi|61102721 PRAME family member 9 [Homo sapiens]
Length = 478
Score = 211 bits (537), Expect = 1e-54
Identities = 165/462 (35%), Positives = 242/462 (52%), Gaps = 34/462 (7%)
Query: 60 MEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQA 119
M+++ P LLELA SLL ++A LE+L LFPPL AF++ +ALK +VQA
Sbjct: 1 MKMSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQA 60
Query: 120 WPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGK 179
WPFR L L LI + P ++ QAV+DGL+A PR+ +L++LD E +
Sbjct: 61 WPFRRLPLRPLI-KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDVCENFWMVW- 118
Query: 180 GASEALAKFPFWLPSAVKA---ETPQATARP------------KPLDKFLSDLLTKVEQS 224
SEA+A F K + P+ R + LD++L+ LL V+Q
Sbjct: 119 --SEAMAHGCFLNAKRNKKPVQDCPRMRGRQPLTVFVELWLKNRTLDEYLTYLLLWVKQR 176
Query: 225 HGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLG 283
LHLCC+KL I M ++ ILK + LD IQE+EV W L P LG
Sbjct: 177 KDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLG 231
Query: 284 RIFNLRSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYIL 339
+ NL+ L L + ++ + + F +Q L L+KL++ S S+L G L +L
Sbjct: 232 HMRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLL 291
Query: 340 SCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVS 399
SCL L L I NC LL++D+ +LS+ + LK LDLS L+ PL LL V+
Sbjct: 292 SCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVA 351
Query: 400 GTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELK 459
TL++LDL C + D+ ++A+LPAL RC L++ S NPI A L +LL HT+ L L
Sbjct: 352 ATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLC 411
Query: 460 QVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
LYP P + +G G + + Q++AE+ +++ ++
Sbjct: 412 VELYPAPRES----YG-ADGTLCWSRFAQIRAELMNRVRDLR 448
>gi|239741047 PREDICTED: PRAME family member 25-like [Homo sapiens]
Length = 474
Score = 209 bits (532), Expect = 5e-54
Identities = 157/454 (34%), Positives = 242/454 (53%), Gaps = 32/454 (7%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
AP LLELA SLL ++A +L++L LFPPL AF + LK +VQAWPF L
Sbjct: 5 APRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQAWPFPCL 64
Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
LGSL+ + P+ + L VVDG++ A + PR+ +L++L+ D ++ F+ + L
Sbjct: 65 PLGSLM-KTPDLEILHYVVDGIDCLLAQKVRPRRRKLQVLELR-DVDENFWTIWSGARPL 122
Query: 186 AKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTK-------------VEQSHGALHLCC 232
+ P + E T +PL F+ L + V+ G++HLCC
Sbjct: 123 SCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRGSVHLCC 182
Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLA-EPNLSAIQLGRIFNLRSL 291
K+ M++ + IL+T+ D IQ LE++ C +++ P LS ++ NLR
Sbjct: 183 TKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWPCMIVEFSPYLSQMR-----NLR-- 235
Query: 292 KLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPLH 347
KLF ++ SS + + F +Q L L+KL++ S S+L G L +LSCL L
Sbjct: 236 KLFISDGCRYLLSSDSQEQIAPFTTQFLKLHCLQKLYMNSVSFLEGHLDQLLSCLKTSLK 295
Query: 348 SLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDL 407
L I NC LL++D+ +LS+ + LK LDLS L+ PL LL V+ TL++LDL
Sbjct: 296 VLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDL 355
Query: 408 KHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPV 467
C + D+ ++A+LPAL RC L++ S NPIS A L +LL HT+ L L LYP P
Sbjct: 356 DDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCLELYPAPR 415
Query: 468 DCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
+ +G G + + Q++AE+ K+++ ++
Sbjct: 416 ES----YG-ADGTLCWSRFTQIRAELMKRVRDLR 444
>gi|239741045 PREDICTED: PRAME family member 23 [Homo sapiens]
Length = 476
Score = 208 bits (529), Expect = 1e-53
Identities = 163/455 (35%), Positives = 238/455 (52%), Gaps = 34/455 (7%)
Query: 67 PLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLH 126
P LLELA SLL ++A LE+L LFPPL AF++ +ALK +VQAWPFR L
Sbjct: 6 PPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLP 65
Query: 127 LGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEALA 186
L LI + P ++ QAV+DGL+A PR+ +L++LD E + SEA+A
Sbjct: 66 LRPLI-KMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVW---SEAMA 121
Query: 187 ----------KFPFWLPSAVKAETP-----QATARPKPLDKFLSDLLTKVEQSHGALHLC 231
K P ++ + P + + + LD++L+ LL V+Q LHLC
Sbjct: 122 HGCFLNAKRNKKPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHLC 181
Query: 232 CRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLGRIFNLRS 290
C+KL I M ++ ILK + LD IQE+EV W L P LG + NL+
Sbjct: 182 CKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLGHMRNLQK 236
Query: 291 LKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPL 346
L L + ++ + + F +Q L L+KL + S S+L G L +LSCL L
Sbjct: 237 LVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSL 296
Query: 347 HSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLD 406
L I NC LL++D+ +LS+ + LK LDLS L+ PL LL V+ TL++LD
Sbjct: 297 KVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLD 356
Query: 407 LKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIP 466
L C + D+ ++A+LPAL C L++ S NPIS A L +LL HT+ L L LYP P
Sbjct: 357 LDDCGIIDSQVNAILPALSCCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYPAP 416
Query: 467 VDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
+ G + + Q++AE+ K+++ ++
Sbjct: 417 RESY-----DADGTLCWSRFPQIRAELMKRVRDLR 446
>gi|59958373 PRAME family member 4 [Homo sapiens]
Length = 478
Score = 207 bits (526), Expect = 2e-53
Identities = 164/462 (35%), Positives = 242/462 (52%), Gaps = 34/462 (7%)
Query: 60 MEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQA 119
M+++ P LLELA SLL ++A LE+L LFPPL AF++ +ALK +VQ+
Sbjct: 1 MKMSIWTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQS 60
Query: 120 WPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGK 179
WPFR L L LI + P ++ QAV+DGL+A PR+ +L++LD E +
Sbjct: 61 WPFRRLPLRPLI-KMPCLEAFQAVLDGLDALLNLGVRPRRWKLQVLDLQDVCENFWMVW- 118
Query: 180 GASEALAKFPFWLPSAVKA---ETPQATARP------------KPLDKFLSDLLTKVEQS 224
SEA+A F K + P+ R + LD++L+ LL V+Q
Sbjct: 119 --SEAMAHGCFLNAKRNKKPVEDCPRMRGRQPLTVFVELWLKNRTLDEYLTCLLLWVKQR 176
Query: 225 HGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLG 283
LHLCC+KL I M ++ ILK + LD IQE+EV W L P LG
Sbjct: 177 KDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLG 231
Query: 284 RIFNLRSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYIL 339
+ NL+ L L + ++ + + F +Q L L+KL++ S S+L G L +L
Sbjct: 232 HMRNLQKLILSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLL 291
Query: 340 SCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVS 399
SCL L L I NC LL++D+ +LS+ + LK LDLS L+ PL LL V+
Sbjct: 292 SCLKTSLKFLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVA 351
Query: 400 GTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELK 459
TL++LDL C + D+ ++A+LPAL RC L++ S NPI A L +LL HT+ L L
Sbjct: 352 ATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLC 411
Query: 460 QVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
LYP P + +G G + + Q++AE+ +++ ++
Sbjct: 412 VELYPAPRES----YG-ADGTLCWSRFAQIRAELMNRVRDLR 448
>gi|226437621 PRAME family member 11 [Homo sapiens]
Length = 436
Score = 185 bits (469), Expect = 1e-46
Identities = 147/420 (35%), Positives = 221/420 (52%), Gaps = 38/420 (9%)
Query: 104 AFAKGHRKALKALVQAWPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELR 163
AF++ +ALK +VQAWPFR L L LI + P ++ QAV+DGL+A PR+ +L+
Sbjct: 3 AFSRRRCEALKLMVQAWPFRRLPLRPLI-KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQ 61
Query: 164 MLDFTLDSEQVFYCGKGASEALAKFPFWLPSAVKAETP-----------------QATAR 206
+LD E + SEA+A F +A + +TP + +
Sbjct: 62 VLDLQDVCENFWMVW---SEAMAHGCFL--NAKRNKTPVQDCPRMRERQPLTVFVELWLK 116
Query: 207 PKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYW 265
+ LD++L+ LL V+Q LHLCC+KL I M ++ ILK + LD IQE+EV W
Sbjct: 117 NRTLDEYLTCLLLWVKQRRDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKW 176
Query: 266 CRDFLVLAEPNLSAIQLGRIFNLRSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLR 322
L P LG + NL+ L L + ++ + + F +Q L L+
Sbjct: 177 ILPILTQFTP-----YLGHLRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQ 231
Query: 323 KLHL-SHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVN 381
KL++ S S+L G L +LSCL L L I NC LL++D+ +LS+ + LK LDLS
Sbjct: 232 KLYMNSVSFLEGHLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGI 291
Query: 382 DLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPIS 441
L+ PL LL V+ TL++LDL C + D+ ++A+LPAL RC L++ S NPI
Sbjct: 292 RLTNYSLVPLQILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPIC 351
Query: 442 SACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
A L +LL HT+ L L LYP P + +G G + + Q++AE+ K+++ ++
Sbjct: 352 MATLENLLSHTIILKNLCLELYPAPQES----YG-ADGTLCWSRFAQIRAELMKKVRHLR 406
>gi|157426839 PRAME family member 17 [Homo sapiens]
Length = 474
Score = 182 bits (461), Expect = 8e-46
Identities = 150/457 (32%), Positives = 222/457 (48%), Gaps = 35/457 (7%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
+P LLELA SLL N+ +L++L +FP + A + H +ALK +VQAWPF L
Sbjct: 5 SPSRLLELAGQSLLRNQFLTIFILDELPREVFPLMFMEASSMRHFEALKLMVQAWPFLRL 64
Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
LGSL+ + P+ ++LQAV+ GL+ A + PR+ +L++LD D + F+ + AL
Sbjct: 65 PLGSLM-KTPHLETLQAVLKGLDTLLAQKLRPRRWKLQVLDLR-DVDGNFWTIWSGARAL 122
Query: 186 AKFPFWLPSAVKAETPQATARPKPL-------------DKFLSDLLTKVEQSHGALHLCC 232
+ P + E T +PL D+ LS L + G +HLCC
Sbjct: 123 SCSPEAMSKRQTVEDYPRTGEHQPLKVFIDLCQKESTLDECLSYLCRWIHYRRGLVHLCC 182
Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLK 292
K+ M S +LK + D IQELE+ C L + A L ++ NLR L
Sbjct: 183 NKVQNYSMPTSSFRNLLKRVYPDSIQELEIKRKCS----LNKTGKFAPYLSQMSNLRKLF 238
Query: 293 LFY------YKWAFSSWVRRPSSYFFS-QLTMLGHLRKLHLSHSYLVGKLHYILSCLWVP 345
L + Y +V F + ++RK+ S + L ++L CL P
Sbjct: 239 LAFGYDDELYVSGQQQFVPDLDCPFLCLYYPQMLYIRKI----SNIKEHLEHLLRCLKNP 294
Query: 346 LHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHL 405
L + C+ L D D+ LS+ + LK+L L + PLG LL V+ TL+ L
Sbjct: 295 LGTFIFCHAYLADQDMECLSQYPSLSQLKELHLIHILMWTTNLEPLGALLEKVAATLEIL 354
Query: 406 DLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPI 465
LK C ++D+ L LLPAL RCS L++ N S+ L LL HT GL +L LYP
Sbjct: 355 TLKDCQIQDSQLRVLLPALSRCSQLTTFYFRGNETSTNALKDLLCHTGGLSKLGLELYPA 414
Query: 466 PVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
P++C RG VN + L ++AE+ L+ ++Q
Sbjct: 415 PLECLDN-----RGHVNWEILAPIRAELMCTLREVRQ 446
>gi|113865933 PRAME family member 16 [Homo sapiens]
Length = 474
Score = 181 bits (460), Expect = 1e-45
Identities = 150/457 (32%), Positives = 222/457 (48%), Gaps = 35/457 (7%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
+P LLELA SLL N+ +L++L +FP + A + H +ALK +VQAWPF L
Sbjct: 5 SPSRLLELAGQSLLRNQFLTIFILDELPREVFPLMFMEASSMRHFEALKLMVQAWPFLRL 64
Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
LGSL+ + P+ ++LQAV+ GL+ A + PR+ +L++LD D + F+ + AL
Sbjct: 65 PLGSLM-KTPHLETLQAVLKGLDTLLAQKLRPRRWKLQVLDLR-DVDGNFWTIWSGARAL 122
Query: 186 AKFPFWLPSAVKAETPQATARPKPL-------------DKFLSDLLTKVEQSHGALHLCC 232
+ P + E T +PL D+ LS L + G +HLCC
Sbjct: 123 SCSPEAMRKRQTVEDYPRTGEHQPLKVFIDLCQKESTLDECLSYLCRWIHYRRGLVHLCC 182
Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLK 292
K+ M S +LK + D IQELE+ C L + A L ++ NLR L
Sbjct: 183 NKVQNYSMPTSSFRNLLKRVYPDSIQELEIKRKCS----LNKTGKFAPYLSQMSNLRKLF 238
Query: 293 LFY------YKWAFSSWVRRPSSYFFS-QLTMLGHLRKLHLSHSYLVGKLHYILSCLWVP 345
L + Y +V F + ++RK+ S + L ++L CL P
Sbjct: 239 LAFGYDDELYVSGQQQFVPDLDCPFLCLYYPQMLYIRKI----SNIKEHLEHLLRCLKNP 294
Query: 346 LHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHL 405
L + C+ L D D+ LS+ + LK+L L + PLG LL V+ TL+ L
Sbjct: 295 LGTFIFCHAYLADQDMECLSQYPSLSQLKELHLIHILMWTTNLEPLGALLEKVAATLEIL 354
Query: 406 DLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPI 465
LK C ++D+ L LLPAL RCS L++ N S+ L LL HT GL +L LYP
Sbjct: 355 TLKDCQIQDSQLRVLLPALSRCSQLTTFYFRGNETSTNALKDLLCHTGGLSKLGLELYPA 414
Query: 466 PVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
P++C RG VN + L ++AE+ L+ ++Q
Sbjct: 415 PLECLDN-----RGHVNWEILAPIRAELMCTLREVRQ 446
>gi|154800493 PRAME family member 22 [Homo sapiens]
Length = 481
Score = 174 bits (441), Expect = 2e-43
Identities = 145/461 (31%), Positives = 226/461 (49%), Gaps = 31/461 (6%)
Query: 60 MEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQA 119
M ++ AP LLELA SLL ++A +L++L LFPPL AF + LK +VQA
Sbjct: 1 MRMSLQAPRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQA 60
Query: 120 WPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGK 179
WPF L LGSL+ + P+ + L VVDG++ A + PR+ +L++L+ D ++ F+
Sbjct: 61 WPFPCLPLGSLM-KTPDLEILHYVVDGIDCLLAQKVRPRRWKLQVLELR-DVDENFWTIW 118
Query: 180 GASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTK-------------VEQSHG 226
+ L+ P + E T +PL F+ L + V+ G
Sbjct: 119 SGARPLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRG 178
Query: 227 ALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIF 286
++HLCC K+ M++ + IL+T+ D IQ LE++ C +++ L ++
Sbjct: 179 SVHLCCTKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWPCMIVEFSRY----LSQMR 234
Query: 287 NLRSLKLFYY---KWAFSSWVRRPS-SYFFSQLTMLGHLRKLHLSH-SYLVGKLHYILSC 341
NLR KLF ++ SS + + F S L L +L+ L++ + G L ++ C
Sbjct: 235 NLR--KLFISDGCRYLLSSDSQEQLVAEFSSVLLRLEYLQMLYVRRVCFFRGHLDQLIRC 292
Query: 342 LWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGT 401
L PL +L + L D+ L R + LK+L+LS L ++ PL LL V+ T
Sbjct: 293 LRSPLETLALTYGFLEKVDLKCLPRYPSLSQLKQLNLSHGALRFIRLEPLRALLEKVAAT 352
Query: 402 LQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQV 461
LQ L L C ++D+ L +LPAL CS+L++ N S L LL HT L L
Sbjct: 353 LQTLFLVDCGIRDSKLRVILPALSCCSNLTTFCFHGNDTSMDGLKDLLRHTGRLSNLSLE 412
Query: 462 LYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
YP P + RG V + L LQAE+ + L+ +++
Sbjct: 413 TYPAPRESL-----DDRGRVISELLTPLQAELMRILREVRE 448
>gi|194306638 PRAME family member 3 [Homo sapiens]
Length = 481
Score = 174 bits (441), Expect = 2e-43
Identities = 145/461 (31%), Positives = 226/461 (49%), Gaps = 31/461 (6%)
Query: 60 MEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQA 119
M ++ AP LLELA SLL ++A +L++L LFPPL AF + LK +VQA
Sbjct: 1 MRMSLQAPRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQA 60
Query: 120 WPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGK 179
WPF L LGSL+ + P+ + L VVDG++ A + PR+ +L++L+ D ++ F+
Sbjct: 61 WPFPCLPLGSLM-KTPDLEILHYVVDGIDCLLAQKVRPRRRKLQVLELR-DVDENFWTIW 118
Query: 180 GASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTK-------------VEQSHG 226
+ L+ P + E T +PL F+ L + V+ G
Sbjct: 119 SGARPLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRG 178
Query: 227 ALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIF 286
++HLCC K+ M++ + IL+T+ D IQ LE++ C +++ L ++
Sbjct: 179 SVHLCCTKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWPCMIVEFIRY----LSQMR 234
Query: 287 NLRSLKLFYY---KWAFSSWVRRPS-SYFFSQLTMLGHLRKLHLSH-SYLVGKLHYILSC 341
NLR KLF ++ SS + + F S L L +L+ L++ + G L ++ C
Sbjct: 235 NLR--KLFISDGCRYLLSSDSQEQLVAEFSSVLLRLEYLQMLYVRRVCFFRGHLDQLIRC 292
Query: 342 LWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGT 401
L PL +L + L D+ L R + LK+L+LS L ++ PL LL V+ T
Sbjct: 293 LRSPLETLALTYGFLEKVDLKCLPRYPSLSQLKQLNLSHGALRFIRLEPLRALLEKVAAT 352
Query: 402 LQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQV 461
LQ L L C ++D+ L +LPAL CS+L++ N S L LL HT L L
Sbjct: 353 LQTLFLVDCGIRDSKLRVILPALSCCSNLTTFCFHGNDTSMDGLKDLLRHTGRLSNLSLE 412
Query: 462 LYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
YP P + RG V + L LQAE+ + L+ +++
Sbjct: 413 TYPAPRESL-----DDRGRVISELLTPLQAELMRILREVRE 448
>gi|7661860 leucine rich repeat containing 14 [Homo sapiens]
Length = 493
Score = 171 bits (433), Expect = 1e-42
Identities = 157/497 (31%), Positives = 222/497 (44%), Gaps = 77/497 (15%)
Query: 69 SLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLHLG 128
+L+ L+ +L + + L L LFP L AF L+ LV WPF L
Sbjct: 3 TLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKTVVLRELVHTWPFPLLSFQ 62
Query: 129 SLIVQW-----------PNQDSLQAVVDGLEAFSAHRACP--------RKSELRMLDFT- 168
L+ + P+ +S+QAV+ GL A H + P RK LR+LD T
Sbjct: 63 QLLQECAHCSRALLQERPSTESMQAVILGLTA-RLHTSEPGASTQPLCRKHALRVLDMTG 121
Query: 169 -LDSEQVFYCGKGASEALAKFPFWLPSAVKAETPQA-----TARPKPLD----------- 211
LD G + W +A A T A A P P
Sbjct: 122 LLDD--------GVEQDPGTMSMWDCTAAVARTCIAQQQGGAAEPGPAPIPVEVRVDLRV 173
Query: 212 -----KFLSDLLTKVEQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWC 266
FL + L S L LCCR L E + + + + +L+ L ++ +++
Sbjct: 174 NRASYAFLREALRSSVGS--PLRLCCRDLRAEDLPMRNTVALLQLLDAGCLRRVDL---- 227
Query: 267 RDFLVLAEPNLSAI--QLGRIFNLRSLKLFYYKWAFSSWVRRPS-------SYFFSQLTM 317
F L LS I + R +L SL+L Y R+PS YF +Q+
Sbjct: 228 -RFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDS----RQPSVDGEDNFRYFLAQMGR 282
Query: 318 LGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLD 377
LR+L + S L G+L +LS L PL SLE+ C LL D+ +L+RS H LKKLD
Sbjct: 283 FTCLRELSMGSSLLSGRLDQLLSTLQSPLESLELAFCALLPEDLRFLARSPHAAHLKKLD 342
Query: 378 LSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSD 437
LS NDLS P LL+A + TL HL+L C L D L A LP L +C+ L L L
Sbjct: 343 LSGNDLSGSQLAPFQGLLQASAATLLHLELTECQLADTQLLATLPILTQCASLRYLGLYG 402
Query: 438 NPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYL------HGVCRGPVNEDKLCQLQA 491
NP+S A L LL ++ EL+ V++P PVDC L + +NE+K +++A
Sbjct: 403 NPLSMAGLKELLRDSVAQAELRTVVHPFPVDCYEGLPWPPPASVLLEASINEEKFARVEA 462
Query: 492 EIQKQLQAMQQADMQWS 508
E+ + L A +A + W+
Sbjct: 463 ELHQLLLASGRAHVLWT 479
>gi|194018546 PRAME family member 10 [Homo sapiens]
Length = 474
Score = 169 bits (429), Expect = 4e-42
Identities = 145/457 (31%), Positives = 220/457 (48%), Gaps = 35/457 (7%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
AP LLELA SLL N+ L++L +FP + AF+ +ALK +VQAWPF L
Sbjct: 5 APSRLLELAGQSLLRNQFLTIFTLDELPREVFPLMFMEAFSMRRFEALKLMVQAWPFLSL 64
Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
LGSL+ + + ++LQAV+ GL+ A + PR+ +L++LD D ++ F+ + L
Sbjct: 65 PLGSLM-KTLHLETLQAVLRGLDTLVAQKVRPRRWKLQVLDLR-DVDENFWTIWSGARVL 122
Query: 186 AKFPFWLPSAVKAETPQATARPKPL-------------DKFLSDLLTKVEQSHGALHLCC 232
+ P + E +PL D+ LS L + G +HLCC
Sbjct: 123 SCSPEAMSKRQTVEDCPRMGEHQPLKVFIDLCLKESTLDECLSYLFGWIHYRRGLVHLCC 182
Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLK 292
K+ M S +L+ + D IQELEV+ C L + A L ++ NLR L
Sbjct: 183 SKVQNYSMPTSSFRNLLERIYPDSIQELEVWKKCS----LNKTGKFAPYLSQMSNLRELF 238
Query: 293 L-FYYKWAFSSWVRRP------SSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVP 345
L F Y+ V+ P S + + +++K+ S + L ++L L P
Sbjct: 239 LAFGYERELYVSVQWPCIPDLDSPFLCLYYPQMLYIKKI----SNIKEHLEHLLRYLKNP 294
Query: 346 LHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHL 405
L + + L D D+ LS+ + LK+L L + PLG LL V+ TL+ L
Sbjct: 295 LGAFIFSDAYLTDRDMECLSQYPSLSQLKELRLIHILMWTTHLEPLGVLLEKVAATLKTL 354
Query: 406 DLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPI 465
LK C ++D L LLPAL CS L++ + N S L LL HT GL +L LYP
Sbjct: 355 VLKDCRIQDPQLRVLLPALSHCSQLTTFNFHGNETSMNALKDLLRHTGGLSKLGLELYPA 414
Query: 466 PVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
P++ Y +G VN + L ++AE+ + L+ ++Q
Sbjct: 415 PLESLDY-----KGHVNWEILTPIRAELMRTLREVRQ 446
>gi|12738831 PRAME family member 1 [Homo sapiens]
Length = 474
Score = 167 bits (422), Expect = 3e-41
Identities = 145/455 (31%), Positives = 223/455 (49%), Gaps = 31/455 (6%)
Query: 66 APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
AP LLELA SLL ++A +E+L L+ PL AF++ H + L +VQAWPF L
Sbjct: 5 APPRLLELAGQSLLRDQALSISAMEELPRVLYLPLFMEAFSRRHFQTLTVMVQAWPFTCL 64
Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
LGSL+ + + ++L+A+++GL + PR+ +L++LD D ++ F+ + AL
Sbjct: 65 PLGSLM-KTLHLETLKALLEGLHMLLTQKDRPRRWKLQVLDLR-DVDENFWARWPGAWAL 122
Query: 186 AKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSH-------------GALHLCC 232
+ FP AE +PL F+ L ++ Q G +HLCC
Sbjct: 123 SCFPETTSKRQTAEDCPRMGEHQPLKVFIDICLKEIPQDECLRYLFQWVYQRRGLVHLCC 182
Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEV--FYWCRDFLVLAEPNLSAIQLGRIFNLRS 290
KL + L + LK + L+ IQELE+ W R L L + NLR
Sbjct: 183 SKLVNYLTPIKYLRKSLKIIYLNSIQELEIRNMSWPRLIRKLR------CYLKEMKNLRK 236
Query: 291 LKLF--YYKWAFSSWVRRPSSYFFSQLTMLGHLRKLHLSH-SYLVGKLHYILSCLWVPLH 347
L ++ + + R + F S L HL+ L + ++ G L ++ CL PL
Sbjct: 237 LVFSRCHHYTSDNELQGRLVAKFSSVFLRLEHLQLLKIKLITFFSGHLEQLIRCLQNPLE 296
Query: 348 SLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDL 407
+LE+ LL+ D+ LS+ LK L+LS L + PLG LL ++ +L+ L L
Sbjct: 297 NLELTYGYLLEEDMKCLSQYPSLGYLKHLNLSYVLLFRISLEPLGALLEKIAASLKTLIL 356
Query: 408 KHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPV 467
+ C + + LSA+LPAL RCS L++ N +S L LL HT GL +L YP P
Sbjct: 357 EGCQIHYSQLSAILPALSRCSQLTTFYFGRNCMSIDALKDLLRHTSGLSKLSLETYPAPE 416
Query: 468 DCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
+ L+ + R VN + L+AE+ L+ ++Q
Sbjct: 417 ES---LNSLVR--VNWEIFTPLRAELMCTLREVRQ 446
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,025,680
Number of Sequences: 37866
Number of extensions: 878835
Number of successful extensions: 3152
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 2906
Number of HSP's gapped (non-prelim): 178
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.