Guide to the Human Genome
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Search of human proteins with 169215813

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169215813 PREDICTED: preferentially expressed antigen in
melanoma-like [Homo sapiens]
         (520 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169216010 PREDICTED: preferentially expressed antigen in mela...  1053   0.0  
gi|169215813 PREDICTED: preferentially expressed antigen in mela...  1053   0.0  
gi|239746677 PREDICTED: preferentially expressed antigen in mela...  1050   0.0  
gi|153792112 PRAME family member 20 [Homo sapiens]                    231   1e-60
gi|153945800 PRAME family member 21 [Homo sapiens]                    231   1e-60
gi|124249372 PRAME family member 12 [Homo sapiens]                    226   5e-59
gi|239741053 PREDICTED: similar to Putative PRAME family member ...   223   4e-58
gi|59676587 PRAME family member 8 [Homo sapiens]                      222   6e-58
gi|59676593 PRAME family member 7 [Homo sapiens]                      220   3e-57
gi|46249373 preferentially expressed antigen in melanoma [Homo s...   219   6e-57
gi|46249371 preferentially expressed antigen in melanoma [Homo s...   219   6e-57
gi|46249369 preferentially expressed antigen in melanoma [Homo s...   219   6e-57
gi|46249367 preferentially expressed antigen in melanoma [Homo s...   219   6e-57
gi|5174641 preferentially expressed antigen in melanoma [Homo sa...   219   6e-57
gi|239741043 PREDICTED: PRAME family member 11 [Homo sapiens]         214   2e-55
gi|58219004 PRAME family member 6 [Homo sapiens]                      214   2e-55
gi|61696142 PRAME family member 5 [Homo sapiens]                      212   6e-55
gi|148356236 PRAME family member 15 [Homo sapiens]                    211   1e-54
gi|61102721 PRAME family member 9 [Homo sapiens]                      211   1e-54
gi|239741047 PREDICTED: PRAME family member 25-like [Homo sapiens]    209   5e-54
gi|239741045 PREDICTED: PRAME family member 23 [Homo sapiens]         208   1e-53
gi|59958373 PRAME family member 4 [Homo sapiens]                      207   2e-53
gi|226437621 PRAME family member 11 [Homo sapiens]                    185   1e-46
gi|157426839 PRAME family member 17 [Homo sapiens]                    182   8e-46
gi|113865933 PRAME family member 16 [Homo sapiens]                    181   1e-45
gi|154800493 PRAME family member 22 [Homo sapiens]                    174   2e-43
gi|194306638 PRAME family member 3 [Homo sapiens]                     174   2e-43
gi|7661860 leucine rich repeat containing 14 [Homo sapiens]           171   1e-42
gi|194018546 PRAME family member 10 [Homo sapiens]                    169   4e-42
gi|12738831 PRAME family member 1 [Homo sapiens]                      167   3e-41

>gi|169216010 PREDICTED: preferentially expressed antigen in
           melanoma-like [Homo sapiens]
          Length = 520

 Score = 1053 bits (2723), Expect = 0.0
 Identities = 520/520 (100%), Positives = 520/520 (100%)

Query: 1   MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60
           MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM
Sbjct: 1   MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60

Query: 61  EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120
           EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW
Sbjct: 61  EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120

Query: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180
           PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG
Sbjct: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180

Query: 181 ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240
           ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM
Sbjct: 181 ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240

Query: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF 300
           AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF
Sbjct: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF 300

Query: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360
           SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD
Sbjct: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360

Query: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420
           ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL
Sbjct: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420

Query: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480
           LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP
Sbjct: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480

Query: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520
           VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV
Sbjct: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520


>gi|169215813 PREDICTED: preferentially expressed antigen in
           melanoma-like [Homo sapiens]
          Length = 520

 Score = 1053 bits (2723), Expect = 0.0
 Identities = 520/520 (100%), Positives = 520/520 (100%)

Query: 1   MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60
           MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM
Sbjct: 1   MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60

Query: 61  EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120
           EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW
Sbjct: 61  EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120

Query: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180
           PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG
Sbjct: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180

Query: 181 ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240
           ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM
Sbjct: 181 ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240

Query: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF 300
           AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF
Sbjct: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF 300

Query: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360
           SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD
Sbjct: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360

Query: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420
           ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL
Sbjct: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420

Query: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480
           LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP
Sbjct: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480

Query: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520
           VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV
Sbjct: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520


>gi|239746677 PREDICTED: preferentially expressed antigen in
           melanoma-like [Homo sapiens]
          Length = 520

 Score = 1050 bits (2715), Expect = 0.0
 Identities = 518/520 (99%), Positives = 518/520 (99%)

Query: 1   MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60
           MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM
Sbjct: 1   MALVLLRPDSSIFANIVAVPSAVQERVTFCPTVPDTEASWVSADCAQDPGTEEAGTERSM 60

Query: 61  EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120
           EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW
Sbjct: 61  EVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAW 120

Query: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180
           PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG
Sbjct: 121 PFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKG 180

Query: 181 ASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240
           ASEAL KFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM
Sbjct: 181 ASEALTKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKM 240

Query: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLKLFYYKWAF 300
           AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRS KLFYYKWAF
Sbjct: 241 AVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSFKLFYYKWAF 300

Query: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360
           SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD
Sbjct: 301 SSWVRRPSSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTD 360

Query: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420
           ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL
Sbjct: 361 ITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSAL 420

Query: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480
           LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP
Sbjct: 421 LPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGP 480

Query: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520
           VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV
Sbjct: 481 VNEDKLCQLQAEIQKQLQAMQQADMQWSPSTVFAYAAGAV 520


>gi|153792112 PRAME family member 20 [Homo sapiens]
          Length = 475

 Score =  231 bits (589), Expect = 1e-60
 Identities = 172/459 (37%), Positives = 248/459 (54%), Gaps = 37/459 (8%)

Query: 67  PLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLH 126
           P  LLELA  SLL +EA     LE+L   LFPPL   AF++ H +ALK +VQAWPF  L 
Sbjct: 6   PPRLLELAGRSLLRDEALAISTLEELPTELFPPLFMEAFSRRHCEALKLMVQAWPFLRLP 65

Query: 127 LGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEALA 186
           LGSL+ + P  ++ QAV+DGL+A   HR   R+ +L++LD    SE  +      SEA+A
Sbjct: 66  LGSLMKR-PCPETFQAVLDGLDALLTHRVRLRRWKLQVLDLQDVSENFWMVW---SEAMA 121

Query: 187 KFPFWLPSAVKAETP-----------------QATARPKPLDKFLSDLLTKVEQSHGALH 229
           +    LP+A+    P                     + + LD++ + L   V+Q  G +H
Sbjct: 122 RR--CLPNAMMNRKPVQDCPRMRGQQPLTVFIDLCLKNRTLDEYFTCLFLWVKQREGLVH 179

Query: 230 LCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLGRIFNL 288
           LCC+KL +  M   ++  ILKT+ LD IQE+EV   W    L    P      LG++ NL
Sbjct: 180 LCCKKLKMLGMLFHNIRNILKTVNLDCIQEVEVNCNWTLPVLAEFTP-----YLGQMRNL 234

Query: 289 RSLKLFYYKWAFSSWVRRPS--SYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVP 345
           R L L      + S  ++    + F +Q   L  L+KL++ S S+L G L  +LSCL   
Sbjct: 235 RKLVLSDIDSRYISPEQKKEFVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQMLSCLKTS 294

Query: 346 LHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHL 405
           L+ L I NC LL++D+ +LS+      LK LDLS   L+     PL  LL  V+ TL++L
Sbjct: 295 LNILAITNCVLLESDLKHLSKYPSIGQLKTLDLSGTRLANFSLVPLQVLLEKVAATLEYL 354

Query: 406 DLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPI 465
           DL  C + D+ ++A+LPAL RC  L++ S   NPIS+A L +LL HT+ L  L   LYP 
Sbjct: 355 DLDDCGIVDSQVNAILPALSRCFELTTFSFRGNPISTATLENLLCHTIRLNNLCLELYPA 414

Query: 466 PVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQAD 504
           P +       VCR      +  QL AE+  +++A+++ +
Sbjct: 415 PRESYDVRGIVCR-----SRFAQLGAELMGRVRALREPE 448


>gi|153945800 PRAME family member 21 [Homo sapiens]
          Length = 475

 Score =  231 bits (589), Expect = 1e-60
 Identities = 172/459 (37%), Positives = 248/459 (54%), Gaps = 37/459 (8%)

Query: 67  PLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLH 126
           P  LLELA  SLL +EA     LE+L   LFPPL   AF++ H +ALK +VQAWPF  L 
Sbjct: 6   PPRLLELAGRSLLRDEALAISTLEELPTELFPPLFMEAFSRRHCEALKLMVQAWPFLRLP 65

Query: 127 LGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEALA 186
           LGSL+ + P  ++ QAV+DGL+A   HR   R+ +L++LD    SE  +      SEA+A
Sbjct: 66  LGSLMKR-PCPETFQAVLDGLDALLTHRVRLRRWKLQVLDLQDVSENFWMVW---SEAMA 121

Query: 187 KFPFWLPSAVKAETP-----------------QATARPKPLDKFLSDLLTKVEQSHGALH 229
           +    LP+A+    P                     + + LD++ + L   V+Q  G +H
Sbjct: 122 RR--CLPNAMMNRKPVQDCPRMRGQQPLTVFIDLCLKNRTLDEYFTCLFLWVKQREGLVH 179

Query: 230 LCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLGRIFNL 288
           LCC+KL +  M   ++  ILKT+ LD IQE+EV   W    L    P      LG++ NL
Sbjct: 180 LCCKKLKMLGMLFHNIRNILKTVNLDCIQEVEVNCNWTLPVLAEFTP-----YLGQMRNL 234

Query: 289 RSLKLFYYKWAFSSWVRRPS--SYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVP 345
           R L L      + S  ++    + F +Q   L  L+KL++ S S+L G L  +LSCL   
Sbjct: 235 RKLVLSDIDSRYISPEQKKEFVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQMLSCLKTS 294

Query: 346 LHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHL 405
           L+ L I NC LL++D+ +LS+      LK LDLS   L+     PL  LL  V+ TL++L
Sbjct: 295 LNILAITNCVLLESDLKHLSKYPSIGQLKTLDLSGTRLANFSLVPLQVLLEKVAATLEYL 354

Query: 406 DLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPI 465
           DL  C + D+ ++A+LPAL RC  L++ S   NPIS+A L +LL HT+ L  L   LYP 
Sbjct: 355 DLDDCGIVDSQVNAILPALSRCFELTTFSFRGNPISTATLENLLCHTIRLNNLCLELYPA 414

Query: 466 PVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQAD 504
           P +       VCR      +  QL AE+  +++A+++ +
Sbjct: 415 PRESYDVRGIVCR-----SRFAQLGAELMGRVRALREPE 448


>gi|124249372 PRAME family member 12 [Homo sapiens]
          Length = 483

 Score =  226 bits (575), Expect = 5e-59
 Identities = 170/459 (37%), Positives = 241/459 (52%), Gaps = 40/459 (8%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           AP  LLELA  SLL + A     LE+L   LFPPL   AF +   + L  +VQAWPF  L
Sbjct: 5   APPRLLELAEQSLLRDRALAIPTLEELPRELFPPLFMEAFTRRCCETLTTMVQAWPFTCL 64

Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
            LGSL+    N +  +AV++GL+A  A +  PR+ +L++LD     E  +    GAS AL
Sbjct: 65  PLGSLMKSC-NLEIFRAVLEGLDALLAQKVRPRRWKLQVLDLRNVDENFWGIWSGAS-AL 122

Query: 186 AKFPFWLPSAV-KAETPQATARP---KPL-------------DKFLSDLLTKVEQSHGAL 228
           +      P A+ K  T     RP   +PL             D+ L+  L   +Q  G L
Sbjct: 123 S------PEALSKRRTAGNCPRPGGQQPLMVILDLCFKNGMLDECLTHFLEWGKQRKGLL 176

Query: 229 HLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAIQLGRIFN 287
           H+CC++L I  +A+  ++ +L T+ LD IQE+EV   W    L+   P      LG++ N
Sbjct: 177 HVCCKELQIFGIAIHRIIEVLNTVELDCIQEVEVCCPWELSILIRFAP-----YLGQMRN 231

Query: 288 LRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLW 343
           LR L LF    +    + R   +   F SQ   L + +KL++ S S+L G L  +L CL 
Sbjct: 232 LRKLVLFNIHVSACIPLDRKEQFVIQFTSQFLKLDYFQKLYMHSVSFLEGHLDQLLRCLQ 291

Query: 344 VPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQ 403
            PL ++ +  C L ++D+ +LS       LK+LDL    L++  P PL  LL     TLQ
Sbjct: 292 APLETVVMTECLLSESDLKHLSWCPSIRQLKELDLRGITLTHFSPEPLSVLLEQAEATLQ 351

Query: 404 HLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLY 463
            LDL+ C + D+ LSA+LPAL RCS LS+ S   N IS A L +LL HT+GL +L   LY
Sbjct: 352 TLDLEDCGIVDSQLSAILPALSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELY 411

Query: 464 PIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
           P P++       +C G     +  QL AE+ K L+ ++Q
Sbjct: 412 PAPLESYDAQGALCWG-----RFSQLGAELMKTLRDLRQ 445


>gi|239741053 PREDICTED: similar to Putative PRAME family member 24
           [Homo sapiens]
          Length = 474

 Score =  223 bits (567), Expect = 4e-58
 Identities = 162/455 (35%), Positives = 236/455 (51%), Gaps = 32/455 (7%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           AP  LLELA   LL ++A     +E+L   LFP L   AF++   + LK +VQAWPF  L
Sbjct: 5   APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64

Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
            LGSL+   P+ +SL++V++G++        PR+S+L++LD     E       GA+   
Sbjct: 65  PLGSLMKS-PHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT--- 120

Query: 186 AKFPFWLPSAVKAETPQATARPKP-------------LDKFLSDLLTKVEQSHGALHLCC 232
           A FP  L     A+    T R +P             LD+ L+ LL   +Q  G LH+CC
Sbjct: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180

Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAIQLGRIFNLRSL 291
           ++L +  M + S++ +L  + LD IQE+EV   W    LV   P      LG++ NLR L
Sbjct: 181 KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAP-----YLGQMRNLRKL 235

Query: 292 KLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPLH 347
            LF  + +          +   F SQ   L + + L + S S+L G L  +L CL   L 
Sbjct: 236 VLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLE 295

Query: 348 SLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDL 407
            + + +C L ++D+ +LS       LK+LDL    L++  P PL  LL  V  TLQ LDL
Sbjct: 296 MVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDL 355

Query: 408 KHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPV 467
           + C + D+ LSA+LP L RCS LS+ S   N IS A L +LL HT+GL +L   LYP P+
Sbjct: 356 EDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPL 415

Query: 468 DCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
           +       +C G     +  +L AE+ K L+ ++Q
Sbjct: 416 ESYDTQGALCWG-----RFAELGAELMKTLRDLRQ 445


>gi|59676587 PRAME family member 8 [Homo sapiens]
          Length = 474

 Score =  222 bits (566), Expect = 6e-58
 Identities = 162/455 (35%), Positives = 236/455 (51%), Gaps = 32/455 (7%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           AP  LLELA   LL ++A     +E+L   LFP L   AF++   + LK +VQAWPF  L
Sbjct: 5   APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64

Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
            LGSL+   P+ +SL++V++G++        PR+S+L++LD     E       GA+   
Sbjct: 65  PLGSLMKS-PHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT--- 120

Query: 186 AKFPFWLPSAVKAETPQATARPKP-------------LDKFLSDLLTKVEQSHGALHLCC 232
           A FP  L     A+    T R +P             LD+ L+ LL   +Q  G LH+CC
Sbjct: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180

Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAIQLGRIFNLRSL 291
           ++L +  M + S++ +L  + LD IQE+EV   W    LV   P      LG++ NLR L
Sbjct: 181 QELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAP-----YLGQMRNLRKL 235

Query: 292 KLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPLH 347
            LF  + +          +   F SQ   L + + L + S S+L G L  +L CL   L 
Sbjct: 236 VLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLE 295

Query: 348 SLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDL 407
            + + +C L ++D+ +LS       LK+LDL    L++  P PL  LL  V  TLQ LDL
Sbjct: 296 MVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDL 355

Query: 408 KHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPV 467
           + C + D+ LSA+LP L RCS LS+ S   N IS A L +LL HT+GL +L   LYP P+
Sbjct: 356 EDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPL 415

Query: 468 DCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
           +       +C G     +  +L AE+ K L+ ++Q
Sbjct: 416 ESYDTQGALCWG-----RFAELGAELMKTLRDLRQ 445


>gi|59676593 PRAME family member 7 [Homo sapiens]
          Length = 474

 Score =  220 bits (560), Expect = 3e-57
 Identities = 161/455 (35%), Positives = 235/455 (51%), Gaps = 32/455 (7%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           AP  LLELA   LL ++A     +E+L   LFP L   AF++   + LK +VQAWPF  L
Sbjct: 5   APPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRL 64

Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
            LGSL+   P+ +SL++V++G++        PR+S+L++LD     E       GA+   
Sbjct: 65  PLGSLMKS-PHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGAT--- 120

Query: 186 AKFPFWLPSAVKAETPQATARPKP-------------LDKFLSDLLTKVEQSHGALHLCC 232
           A FP  L     A+    T R +P             LD+ L+ LL   +Q  G LH+CC
Sbjct: 121 ASFPEALSQKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCC 180

Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAIQLGRIFNLRSL 291
           ++L +  M + S++ +L  + LD IQE+EV   W    LV   P      LG++ NLR L
Sbjct: 181 KELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAP-----YLGQMRNLRKL 235

Query: 292 KLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPLH 347
            LF  + +          +   F SQ   L + + L + S S+L G L  +L CL   L 
Sbjct: 236 VLFNIRASACIPPDNKGQFIARFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLE 295

Query: 348 SLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDL 407
            + + +C L ++D+ +LS       LK+LDL    L++  P PL  LL  V  TLQ LDL
Sbjct: 296 MVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDL 355

Query: 408 KHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPV 467
           + C + D+ LSA+LP L RCS LS+ S   N IS A L +LL HT+GL +L   LYP P+
Sbjct: 356 EDCGIMDSQLSAILPVLSRCSQLSTFSFCGNLISMAALENLLRHTVGLSKLSLELYPAPL 415

Query: 468 DCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
           +       +C G     +  +L AE+ K  + ++Q
Sbjct: 416 ESYDTQGALCWG-----RFAELGAELMKTPRDLRQ 445


>gi|46249373 preferentially expressed antigen in melanoma [Homo
           sapiens]
          Length = 509

 Score =  219 bits (557), Expect = 6e-57
 Identities = 166/471 (35%), Positives = 241/471 (51%), Gaps = 40/471 (8%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           +P  L+ELA  SLL +EA     LE L   LFPPL  AAF   H + LKA+VQAWPF  L
Sbjct: 22  SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81

Query: 126 HLGSLIV-QWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC-GKGASE 183
            LG L+  Q  + ++ +AV+DGL+   A    PR+ +L++LD   +S Q F+    G   
Sbjct: 82  PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141

Query: 184 ALAKFPFWLPSAVKAETPQ------ATARPKPL----------------DKFLSDLLTKV 221
           +L  FP   P A +  T +      +T   +P                 D+  S L+ KV
Sbjct: 142 SLYSFPE--PEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKV 199

Query: 222 EQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAI 280
           ++    L LCC+KL I  M +  +  ILK ++LD I++LEV   W    L    P     
Sbjct: 200 KRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP----- 254

Query: 281 QLGRIFNLRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLH 336
            LG++ NLR L L +   +      +   Y   F SQ   L  L+ L++ S  +L G+L 
Sbjct: 255 YLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLD 314

Query: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
            +L  +  PL +L I NC+L + D+ +LS+S   + L  L LS   L+ + P PL  LL 
Sbjct: 315 QLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLE 374

Query: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
             S TLQ L    C + D  L ALLP+L  CS L++LS   N IS + L SLL+H +GL 
Sbjct: 375 RASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLS 434

Query: 457 ELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQADMQW 507
            L  VLYP+P++    +HG     ++ ++L  L A +++ L  + +  M W
Sbjct: 435 NLTHVLYPVPLESYEDIHGT----LHLERLAYLHARLRELLCELGRPSMVW 481


>gi|46249371 preferentially expressed antigen in melanoma [Homo
           sapiens]
          Length = 509

 Score =  219 bits (557), Expect = 6e-57
 Identities = 166/471 (35%), Positives = 241/471 (51%), Gaps = 40/471 (8%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           +P  L+ELA  SLL +EA     LE L   LFPPL  AAF   H + LKA+VQAWPF  L
Sbjct: 22  SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81

Query: 126 HLGSLIV-QWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC-GKGASE 183
            LG L+  Q  + ++ +AV+DGL+   A    PR+ +L++LD   +S Q F+    G   
Sbjct: 82  PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141

Query: 184 ALAKFPFWLPSAVKAETPQ------ATARPKPL----------------DKFLSDLLTKV 221
           +L  FP   P A +  T +      +T   +P                 D+  S L+ KV
Sbjct: 142 SLYSFPE--PEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKV 199

Query: 222 EQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAI 280
           ++    L LCC+KL I  M +  +  ILK ++LD I++LEV   W    L    P     
Sbjct: 200 KRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP----- 254

Query: 281 QLGRIFNLRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLH 336
            LG++ NLR L L +   +      +   Y   F SQ   L  L+ L++ S  +L G+L 
Sbjct: 255 YLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLD 314

Query: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
            +L  +  PL +L I NC+L + D+ +LS+S   + L  L LS   L+ + P PL  LL 
Sbjct: 315 QLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLE 374

Query: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
             S TLQ L    C + D  L ALLP+L  CS L++LS   N IS + L SLL+H +GL 
Sbjct: 375 RASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLS 434

Query: 457 ELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQADMQW 507
            L  VLYP+P++    +HG     ++ ++L  L A +++ L  + +  M W
Sbjct: 435 NLTHVLYPVPLESYEDIHGT----LHLERLAYLHARLRELLCELGRPSMVW 481


>gi|46249369 preferentially expressed antigen in melanoma [Homo
           sapiens]
          Length = 509

 Score =  219 bits (557), Expect = 6e-57
 Identities = 166/471 (35%), Positives = 241/471 (51%), Gaps = 40/471 (8%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           +P  L+ELA  SLL +EA     LE L   LFPPL  AAF   H + LKA+VQAWPF  L
Sbjct: 22  SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81

Query: 126 HLGSLIV-QWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC-GKGASE 183
            LG L+  Q  + ++ +AV+DGL+   A    PR+ +L++LD   +S Q F+    G   
Sbjct: 82  PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141

Query: 184 ALAKFPFWLPSAVKAETPQ------ATARPKPL----------------DKFLSDLLTKV 221
           +L  FP   P A +  T +      +T   +P                 D+  S L+ KV
Sbjct: 142 SLYSFPE--PEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKV 199

Query: 222 EQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAI 280
           ++    L LCC+KL I  M +  +  ILK ++LD I++LEV   W    L    P     
Sbjct: 200 KRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP----- 254

Query: 281 QLGRIFNLRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLH 336
            LG++ NLR L L +   +      +   Y   F SQ   L  L+ L++ S  +L G+L 
Sbjct: 255 YLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLD 314

Query: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
            +L  +  PL +L I NC+L + D+ +LS+S   + L  L LS   L+ + P PL  LL 
Sbjct: 315 QLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLE 374

Query: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
             S TLQ L    C + D  L ALLP+L  CS L++LS   N IS + L SLL+H +GL 
Sbjct: 375 RASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLS 434

Query: 457 ELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQADMQW 507
            L  VLYP+P++    +HG     ++ ++L  L A +++ L  + +  M W
Sbjct: 435 NLTHVLYPVPLESYEDIHGT----LHLERLAYLHARLRELLCELGRPSMVW 481


>gi|46249367 preferentially expressed antigen in melanoma [Homo
           sapiens]
          Length = 509

 Score =  219 bits (557), Expect = 6e-57
 Identities = 166/471 (35%), Positives = 241/471 (51%), Gaps = 40/471 (8%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           +P  L+ELA  SLL +EA     LE L   LFPPL  AAF   H + LKA+VQAWPF  L
Sbjct: 22  SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81

Query: 126 HLGSLIV-QWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC-GKGASE 183
            LG L+  Q  + ++ +AV+DGL+   A    PR+ +L++LD   +S Q F+    G   
Sbjct: 82  PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141

Query: 184 ALAKFPFWLPSAVKAETPQ------ATARPKPL----------------DKFLSDLLTKV 221
           +L  FP   P A +  T +      +T   +P                 D+  S L+ KV
Sbjct: 142 SLYSFPE--PEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKV 199

Query: 222 EQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAI 280
           ++    L LCC+KL I  M +  +  ILK ++LD I++LEV   W    L    P     
Sbjct: 200 KRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP----- 254

Query: 281 QLGRIFNLRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLH 336
            LG++ NLR L L +   +      +   Y   F SQ   L  L+ L++ S  +L G+L 
Sbjct: 255 YLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLD 314

Query: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
            +L  +  PL +L I NC+L + D+ +LS+S   + L  L LS   L+ + P PL  LL 
Sbjct: 315 QLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLE 374

Query: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
             S TLQ L    C + D  L ALLP+L  CS L++LS   N IS + L SLL+H +GL 
Sbjct: 375 RASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLS 434

Query: 457 ELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQADMQW 507
            L  VLYP+P++    +HG     ++ ++L  L A +++ L  + +  M W
Sbjct: 435 NLTHVLYPVPLESYEDIHGT----LHLERLAYLHARLRELLCELGRPSMVW 481


>gi|5174641 preferentially expressed antigen in melanoma [Homo
           sapiens]
          Length = 509

 Score =  219 bits (557), Expect = 6e-57
 Identities = 166/471 (35%), Positives = 241/471 (51%), Gaps = 40/471 (8%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           +P  L+ELA  SLL +EA     LE L   LFPPL  AAF   H + LKA+VQAWPF  L
Sbjct: 22  SPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCL 81

Query: 126 HLGSLIV-QWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC-GKGASE 183
            LG L+  Q  + ++ +AV+DGL+   A    PR+ +L++LD   +S Q F+    G   
Sbjct: 82  PLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRA 141

Query: 184 ALAKFPFWLPSAVKAETPQ------ATARPKPL----------------DKFLSDLLTKV 221
           +L  FP   P A +  T +      +T   +P                 D+  S L+ KV
Sbjct: 142 SLYSFPE--PEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKV 199

Query: 222 EQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFY-WCRDFLVLAEPNLSAI 280
           ++    L LCC+KL I  M +  +  ILK ++LD I++LEV   W    L    P     
Sbjct: 200 KRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSP----- 254

Query: 281 QLGRIFNLRSLKLFYYKWAFSSWVRRPSSY---FFSQLTMLGHLRKLHL-SHSYLVGKLH 336
            LG++ NLR L L +   +      +   Y   F SQ   L  L+ L++ S  +L G+L 
Sbjct: 255 YLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLD 314

Query: 337 YILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLR 396
            +L  +  PL +L I NC+L + D+ +LS+S   + L  L LS   L+ + P PL  LL 
Sbjct: 315 QLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLE 374

Query: 397 AVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLM 456
             S TLQ L    C + D  L ALLP+L  CS L++LS   N IS + L SLL+H +GL 
Sbjct: 375 RASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLS 434

Query: 457 ELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQADMQW 507
            L  VLYP+P++    +HG     ++ ++L  L A +++ L  + +  M W
Sbjct: 435 NLTHVLYPVPLESYEDIHGT----LHLERLAYLHARLRELLCELGRPSMVW 481


>gi|239741043 PREDICTED: PRAME family member 11 [Homo sapiens]
          Length = 513

 Score =  214 bits (545), Expect = 2e-55
 Identities = 166/466 (35%), Positives = 246/466 (52%), Gaps = 38/466 (8%)

Query: 58  RSMEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALV 117
           R M+++   P  LLEL   SLL ++A     LE+L   LFPPL   AF++   +ALK +V
Sbjct: 34  RFMKMSIRIPPRLLELXGRSLLRDQALAVSTLEELPTELFPPLFMEAFSRRRCEALKLMV 93

Query: 118 QAWPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYC 177
           QAWPFR L L  LI + P  ++ QAV+DGL+A       PR+ +L++LD     E  +  
Sbjct: 94  QAWPFRRLPLRPLI-KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDVCENFWMV 152

Query: 178 GKGASEALAKFPFWLPSAVKAETP-----------------QATARPKPLDKFLSDLLTK 220
               SEA+A   F   +A + +TP                 +   + + LD++L+ LL  
Sbjct: 153 W---SEAMAHGCFL--NAKRNKTPVQDCPRMRERQPLTVFVELWLKNRTLDEYLTCLLLW 207

Query: 221 VEQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSA 279
           V+Q    LHLCC+KL I  M   ++  ILK + LD IQE+EV   W    L    P    
Sbjct: 208 VKQRRDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWILPILTQFTP---- 263

Query: 280 IQLGRIFNLRSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKL 335
             LG + NL+ L L +    ++      +   + F +Q   L  L+KL++ S S+L G L
Sbjct: 264 -YLGHLRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHL 322

Query: 336 HYILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLL 395
             +LSCL   L  L I NC LL++D+ +LS+    + LK LDLS   L+     PL  LL
Sbjct: 323 DQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILL 382

Query: 396 RAVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGL 455
             V+ TL++LDL  C + D+ ++A+LPAL RC  L++ S   NPI  A L +LL HT+ L
Sbjct: 383 EKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIIL 442

Query: 456 MELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
             L   LYP P +     +G   G +   +  Q++AE+ K+++ ++
Sbjct: 443 KNLCLELYPAPQES----YG-ADGTLCWSRFAQIRAELMKKVRHLR 483


>gi|58219004 PRAME family member 6 [Homo sapiens]
          Length = 476

 Score =  214 bits (544), Expect = 2e-55
 Identities = 165/457 (36%), Positives = 241/457 (52%), Gaps = 38/457 (8%)

Query: 67  PLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLH 126
           P  LLELA  SLL ++A     LE+L   LFPPL   AF++   +ALK +VQAWPFR L 
Sbjct: 6   PPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLP 65

Query: 127 LGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEALA 186
           L  LI + P  ++ QAV+DGL+A       PR+ +L++LD     E  +      SEA+A
Sbjct: 66  LRPLI-KMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVW---SEAMA 121

Query: 187 KFPFWLPSAVKAETP-----------------QATARPKPLDKFLSDLLTKVEQSHGALH 229
           +  F   +A + +TP                 +   + + LD++L+ LL  V+Q    LH
Sbjct: 122 RGCFL--NAKRNKTPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLH 179

Query: 230 LCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLGRIFNL 288
           LCC+KL I  M   ++  ILK + LD IQE+EV   W    L    P      LG + NL
Sbjct: 180 LCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLGHMRNL 234

Query: 289 RSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWV 344
           + L L +    ++      +   + F +Q   L  L+KL + S S+L G L  +LSCL  
Sbjct: 235 QKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKT 294

Query: 345 PLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQH 404
            L  L I NC LL++D+ +LS+    + LK LDLS   L+     PL  LL  V+ TL++
Sbjct: 295 SLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEY 354

Query: 405 LDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYP 464
           LDL  C + D+ ++A+LPAL RC  L++ S   NPIS A L +LL HT+ L  L   LYP
Sbjct: 355 LDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYP 414

Query: 465 IPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
            P +          G +   +  Q++AE+ K+++ ++
Sbjct: 415 APRESY-----DADGTLCWSRFAQIRAELMKRVRDLR 446


>gi|61696142 PRAME family member 5 [Homo sapiens]
          Length = 476

 Score =  212 bits (540), Expect = 6e-55
 Identities = 164/455 (36%), Positives = 239/455 (52%), Gaps = 34/455 (7%)

Query: 67  PLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLH 126
           P  LLELA  SLL ++A     LE+L   LFPPL   AF++   +ALK +VQAWPFR L 
Sbjct: 6   PPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLP 65

Query: 127 LGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEALA 186
           L  LI + P  ++ QAV+DGL+A       PR+ +L++LD     E  +      SEA+A
Sbjct: 66  LRPLI-KMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVW---SEAMA 121

Query: 187 ----------KFPFWLPSAVKAETP-----QATARPKPLDKFLSDLLTKVEQSHGALHLC 231
                     K P      ++ + P     +   + + LD++L+ LL  V+Q    LHLC
Sbjct: 122 HGCFLNAKRNKKPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHLC 181

Query: 232 CRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLGRIFNLRS 290
           C+KL I  M   ++  ILK + LD IQE+EV   W    L    P      LG + NL+ 
Sbjct: 182 CKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLGHMRNLQK 236

Query: 291 LKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPL 346
           L L +    ++      +   + F +Q   L  L+KL + S S+L G L  +LSCL   L
Sbjct: 237 LVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSL 296

Query: 347 HSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLD 406
             L I NC LL++D+ +LS+    + LK LDLS   L+     PL  LL  V+ TL++LD
Sbjct: 297 KVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLD 356

Query: 407 LKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIP 466
           L  C + D+ ++A+LPAL RC  L++ S   NPIS A L +LL HT+ L  L   LYP P
Sbjct: 357 LDDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYPAP 416

Query: 467 VDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
            +          G +   +  Q++AE+ K+++ ++
Sbjct: 417 RESY-----DADGTLCWSRFAQIRAELMKRVRDLR 446


>gi|148356236 PRAME family member 15 [Homo sapiens]
          Length = 478

 Score =  211 bits (537), Expect = 1e-54
 Identities = 165/462 (35%), Positives = 242/462 (52%), Gaps = 34/462 (7%)

Query: 60  MEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQA 119
           M+++   P  LLELA  SLL ++A     LE+L   LFPPL   AF++   +ALK +VQA
Sbjct: 1   MKMSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQA 60

Query: 120 WPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGK 179
           WPFR L L  LI + P  ++ QAV+DGL+A       PR+ +L++LD     E  +    
Sbjct: 61  WPFRRLPLRPLI-KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDVCENFWMVW- 118

Query: 180 GASEALAKFPFWLPSAVKA---ETPQATARP------------KPLDKFLSDLLTKVEQS 224
             SEA+A   F      K    + P+   R             + LD++L+ LL  V+Q 
Sbjct: 119 --SEAMAHGCFLNAKRNKKPVQDCPRMRGRQPLTVFVELWLKNRTLDEYLTYLLLWVKQR 176

Query: 225 HGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLG 283
              LHLCC+KL I  M   ++  ILK + LD IQE+EV   W    L    P      LG
Sbjct: 177 KDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLG 231

Query: 284 RIFNLRSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYIL 339
            + NL+ L L +    ++      +   + F +Q   L  L+KL++ S S+L G L  +L
Sbjct: 232 HMRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLL 291

Query: 340 SCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVS 399
           SCL   L  L I NC LL++D+ +LS+    + LK LDLS   L+     PL  LL  V+
Sbjct: 292 SCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVA 351

Query: 400 GTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELK 459
            TL++LDL  C + D+ ++A+LPAL RC  L++ S   NPI  A L +LL HT+ L  L 
Sbjct: 352 ATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLC 411

Query: 460 QVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
             LYP P +     +G   G +   +  Q++AE+  +++ ++
Sbjct: 412 VELYPAPRES----YG-ADGTLCWSRFAQIRAELMNRVRDLR 448


>gi|61102721 PRAME family member 9 [Homo sapiens]
          Length = 478

 Score =  211 bits (537), Expect = 1e-54
 Identities = 165/462 (35%), Positives = 242/462 (52%), Gaps = 34/462 (7%)

Query: 60  MEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQA 119
           M+++   P  LLELA  SLL ++A     LE+L   LFPPL   AF++   +ALK +VQA
Sbjct: 1   MKMSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQA 60

Query: 120 WPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGK 179
           WPFR L L  LI + P  ++ QAV+DGL+A       PR+ +L++LD     E  +    
Sbjct: 61  WPFRRLPLRPLI-KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQVLDLQDVCENFWMVW- 118

Query: 180 GASEALAKFPFWLPSAVKA---ETPQATARP------------KPLDKFLSDLLTKVEQS 224
             SEA+A   F      K    + P+   R             + LD++L+ LL  V+Q 
Sbjct: 119 --SEAMAHGCFLNAKRNKKPVQDCPRMRGRQPLTVFVELWLKNRTLDEYLTYLLLWVKQR 176

Query: 225 HGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLG 283
              LHLCC+KL I  M   ++  ILK + LD IQE+EV   W    L    P      LG
Sbjct: 177 KDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLG 231

Query: 284 RIFNLRSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYIL 339
            + NL+ L L +    ++      +   + F +Q   L  L+KL++ S S+L G L  +L
Sbjct: 232 HMRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLL 291

Query: 340 SCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVS 399
           SCL   L  L I NC LL++D+ +LS+    + LK LDLS   L+     PL  LL  V+
Sbjct: 292 SCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVA 351

Query: 400 GTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELK 459
            TL++LDL  C + D+ ++A+LPAL RC  L++ S   NPI  A L +LL HT+ L  L 
Sbjct: 352 ATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLC 411

Query: 460 QVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
             LYP P +     +G   G +   +  Q++AE+  +++ ++
Sbjct: 412 VELYPAPRES----YG-ADGTLCWSRFAQIRAELMNRVRDLR 448


>gi|239741047 PREDICTED: PRAME family member 25-like [Homo sapiens]
          Length = 474

 Score =  209 bits (532), Expect = 5e-54
 Identities = 157/454 (34%), Positives = 242/454 (53%), Gaps = 32/454 (7%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           AP  LLELA  SLL ++A    +L++L   LFPPL   AF     + LK +VQAWPF  L
Sbjct: 5   APRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQAWPFPCL 64

Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
            LGSL+ + P+ + L  VVDG++   A +  PR+ +L++L+   D ++ F+     +  L
Sbjct: 65  PLGSLM-KTPDLEILHYVVDGIDCLLAQKVRPRRRKLQVLELR-DVDENFWTIWSGARPL 122

Query: 186 AKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTK-------------VEQSHGALHLCC 232
           +  P  +      E    T   +PL  F+   L +             V+   G++HLCC
Sbjct: 123 SCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRGSVHLCC 182

Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLA-EPNLSAIQLGRIFNLRSL 291
            K+    M++ +   IL+T+  D IQ LE++  C   +++   P LS ++     NLR  
Sbjct: 183 TKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWPCMIVEFSPYLSQMR-----NLR-- 235

Query: 292 KLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPLH 347
           KLF     ++  SS  +   + F +Q   L  L+KL++ S S+L G L  +LSCL   L 
Sbjct: 236 KLFISDGCRYLLSSDSQEQIAPFTTQFLKLHCLQKLYMNSVSFLEGHLDQLLSCLKTSLK 295

Query: 348 SLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDL 407
            L I NC LL++D+ +LS+    + LK LDLS   L+     PL  LL  V+ TL++LDL
Sbjct: 296 VLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDL 355

Query: 408 KHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPV 467
             C + D+ ++A+LPAL RC  L++ S   NPIS A L +LL HT+ L  L   LYP P 
Sbjct: 356 DDCGIIDSQVNAILPALSRCFELNTFSFCGNPISMATLENLLSHTIILKNLCLELYPAPR 415

Query: 468 DCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
           +     +G   G +   +  Q++AE+ K+++ ++
Sbjct: 416 ES----YG-ADGTLCWSRFTQIRAELMKRVRDLR 444


>gi|239741045 PREDICTED: PRAME family member 23 [Homo sapiens]
          Length = 476

 Score =  208 bits (529), Expect = 1e-53
 Identities = 163/455 (35%), Positives = 238/455 (52%), Gaps = 34/455 (7%)

Query: 67  PLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLH 126
           P  LLELA  SLL ++A     LE+L   LFPPL   AF++   +ALK +VQAWPFR L 
Sbjct: 6   PPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLP 65

Query: 127 LGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEALA 186
           L  LI + P  ++ QAV+DGL+A       PR+ +L++LD     E  +      SEA+A
Sbjct: 66  LRPLI-KMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVW---SEAMA 121

Query: 187 ----------KFPFWLPSAVKAETP-----QATARPKPLDKFLSDLLTKVEQSHGALHLC 231
                     K P      ++ + P     +   + + LD++L+ LL  V+Q    LHLC
Sbjct: 122 HGCFLNAKRNKKPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHLC 181

Query: 232 CRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLGRIFNLRS 290
           C+KL I  M   ++  ILK + LD IQE+EV   W    L    P      LG + NL+ 
Sbjct: 182 CKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLGHMRNLQK 236

Query: 291 LKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYILSCLWVPL 346
           L L +    ++      +   + F +Q   L  L+KL + S S+L G L  +LSCL   L
Sbjct: 237 LVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSL 296

Query: 347 HSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLD 406
             L I NC LL++D+ +LS+    + LK LDLS   L+     PL  LL  V+ TL++LD
Sbjct: 297 KVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLD 356

Query: 407 LKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIP 466
           L  C + D+ ++A+LPAL  C  L++ S   NPIS A L +LL HT+ L  L   LYP P
Sbjct: 357 LDDCGIIDSQVNAILPALSCCFELNTFSFCGNPISMATLENLLSHTIILKNLCVELYPAP 416

Query: 467 VDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
            +          G +   +  Q++AE+ K+++ ++
Sbjct: 417 RESY-----DADGTLCWSRFPQIRAELMKRVRDLR 446


>gi|59958373 PRAME family member 4 [Homo sapiens]
          Length = 478

 Score =  207 bits (526), Expect = 2e-53
 Identities = 164/462 (35%), Positives = 242/462 (52%), Gaps = 34/462 (7%)

Query: 60  MEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQA 119
           M+++   P  LLELA  SLL ++A     LE+L   LFPPL   AF++   +ALK +VQ+
Sbjct: 1   MKMSIWTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQS 60

Query: 120 WPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGK 179
           WPFR L L  LI + P  ++ QAV+DGL+A       PR+ +L++LD     E  +    
Sbjct: 61  WPFRRLPLRPLI-KMPCLEAFQAVLDGLDALLNLGVRPRRWKLQVLDLQDVCENFWMVW- 118

Query: 180 GASEALAKFPFWLPSAVKA---ETPQATARP------------KPLDKFLSDLLTKVEQS 224
             SEA+A   F      K    + P+   R             + LD++L+ LL  V+Q 
Sbjct: 119 --SEAMAHGCFLNAKRNKKPVEDCPRMRGRQPLTVFVELWLKNRTLDEYLTCLLLWVKQR 176

Query: 225 HGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYWCRDFLVLAEPNLSAIQLG 283
              LHLCC+KL I  M   ++  ILK + LD IQE+EV   W    L    P      LG
Sbjct: 177 KDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTP-----YLG 231

Query: 284 RIFNLRSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLRKLHL-SHSYLVGKLHYIL 339
            + NL+ L L +    ++      +   + F +Q   L  L+KL++ S S+L G L  +L
Sbjct: 232 HMRNLQKLILSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQKLYMNSVSFLEGHLDQLL 291

Query: 340 SCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVS 399
           SCL   L  L I NC LL++D+ +LS+    + LK LDLS   L+     PL  LL  V+
Sbjct: 292 SCLKTSLKFLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVA 351

Query: 400 GTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELK 459
            TL++LDL  C + D+ ++A+LPAL RC  L++ S   NPI  A L +LL HT+ L  L 
Sbjct: 352 ATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPICMATLENLLSHTIILKNLC 411

Query: 460 QVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
             LYP P +     +G   G +   +  Q++AE+  +++ ++
Sbjct: 412 VELYPAPRES----YG-ADGTLCWSRFAQIRAELMNRVRDLR 448


>gi|226437621 PRAME family member 11 [Homo sapiens]
          Length = 436

 Score =  185 bits (469), Expect = 1e-46
 Identities = 147/420 (35%), Positives = 221/420 (52%), Gaps = 38/420 (9%)

Query: 104 AFAKGHRKALKALVQAWPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELR 163
           AF++   +ALK +VQAWPFR L L  LI + P  ++ QAV+DGL+A       PR+ +L+
Sbjct: 3   AFSRRRCEALKLMVQAWPFRRLPLRPLI-KMPCLEAFQAVLDGLDALLTQGVRPRRWKLQ 61

Query: 164 MLDFTLDSEQVFYCGKGASEALAKFPFWLPSAVKAETP-----------------QATAR 206
           +LD     E  +      SEA+A   F   +A + +TP                 +   +
Sbjct: 62  VLDLQDVCENFWMVW---SEAMAHGCFL--NAKRNKTPVQDCPRMRERQPLTVFVELWLK 116

Query: 207 PKPLDKFLSDLLTKVEQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEV-FYW 265
            + LD++L+ LL  V+Q    LHLCC+KL I  M   ++  ILK + LD IQE+EV   W
Sbjct: 117 NRTLDEYLTCLLLWVKQRRDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKW 176

Query: 266 CRDFLVLAEPNLSAIQLGRIFNLRSLKLFYY---KWAFSSWVRRPSSYFFSQLTMLGHLR 322
               L    P      LG + NL+ L L +    ++      +   + F +Q   L  L+
Sbjct: 177 ILPILTQFTP-----YLGHLRNLQKLVLSHMDVSRYVSPEQKKEIVTQFTTQFLKLRCLQ 231

Query: 323 KLHL-SHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVN 381
           KL++ S S+L G L  +LSCL   L  L I NC LL++D+ +LS+    + LK LDLS  
Sbjct: 232 KLYMNSVSFLEGHLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGI 291

Query: 382 DLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPIS 441
            L+     PL  LL  V+ TL++LDL  C + D+ ++A+LPAL RC  L++ S   NPI 
Sbjct: 292 RLTNYSLVPLQILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPIC 351

Query: 442 SACLLSLLEHTMGLMELKQVLYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQ 501
            A L +LL HT+ L  L   LYP P +     +G   G +   +  Q++AE+ K+++ ++
Sbjct: 352 MATLENLLSHTIILKNLCLELYPAPQES----YG-ADGTLCWSRFAQIRAELMKKVRHLR 406


>gi|157426839 PRAME family member 17 [Homo sapiens]
          Length = 474

 Score =  182 bits (461), Expect = 8e-46
 Identities = 150/457 (32%), Positives = 222/457 (48%), Gaps = 35/457 (7%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           +P  LLELA  SLL N+     +L++L   +FP +   A +  H +ALK +VQAWPF  L
Sbjct: 5   SPSRLLELAGQSLLRNQFLTIFILDELPREVFPLMFMEASSMRHFEALKLMVQAWPFLRL 64

Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
            LGSL+ + P+ ++LQAV+ GL+   A +  PR+ +L++LD   D +  F+     + AL
Sbjct: 65  PLGSLM-KTPHLETLQAVLKGLDTLLAQKLRPRRWKLQVLDLR-DVDGNFWTIWSGARAL 122

Query: 186 AKFPFWLPSAVKAETPQATARPKPL-------------DKFLSDLLTKVEQSHGALHLCC 232
           +  P  +      E    T   +PL             D+ LS L   +    G +HLCC
Sbjct: 123 SCSPEAMSKRQTVEDYPRTGEHQPLKVFIDLCQKESTLDECLSYLCRWIHYRRGLVHLCC 182

Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLK 292
            K+    M   S   +LK +  D IQELE+   C     L +    A  L ++ NLR L 
Sbjct: 183 NKVQNYSMPTSSFRNLLKRVYPDSIQELEIKRKCS----LNKTGKFAPYLSQMSNLRKLF 238

Query: 293 LFY------YKWAFSSWVRRPSSYFFS-QLTMLGHLRKLHLSHSYLVGKLHYILSCLWVP 345
           L +      Y      +V      F       + ++RK+    S +   L ++L CL  P
Sbjct: 239 LAFGYDDELYVSGQQQFVPDLDCPFLCLYYPQMLYIRKI----SNIKEHLEHLLRCLKNP 294

Query: 346 LHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHL 405
           L +   C+  L D D+  LS+    + LK+L L    +      PLG LL  V+ TL+ L
Sbjct: 295 LGTFIFCHAYLADQDMECLSQYPSLSQLKELHLIHILMWTTNLEPLGALLEKVAATLEIL 354

Query: 406 DLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPI 465
            LK C ++D+ L  LLPAL RCS L++     N  S+  L  LL HT GL +L   LYP 
Sbjct: 355 TLKDCQIQDSQLRVLLPALSRCSQLTTFYFRGNETSTNALKDLLCHTGGLSKLGLELYPA 414

Query: 466 PVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
           P++C        RG VN + L  ++AE+   L+ ++Q
Sbjct: 415 PLECLDN-----RGHVNWEILAPIRAELMCTLREVRQ 446


>gi|113865933 PRAME family member 16 [Homo sapiens]
          Length = 474

 Score =  181 bits (460), Expect = 1e-45
 Identities = 150/457 (32%), Positives = 222/457 (48%), Gaps = 35/457 (7%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           +P  LLELA  SLL N+     +L++L   +FP +   A +  H +ALK +VQAWPF  L
Sbjct: 5   SPSRLLELAGQSLLRNQFLTIFILDELPREVFPLMFMEASSMRHFEALKLMVQAWPFLRL 64

Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
            LGSL+ + P+ ++LQAV+ GL+   A +  PR+ +L++LD   D +  F+     + AL
Sbjct: 65  PLGSLM-KTPHLETLQAVLKGLDTLLAQKLRPRRWKLQVLDLR-DVDGNFWTIWSGARAL 122

Query: 186 AKFPFWLPSAVKAETPQATARPKPL-------------DKFLSDLLTKVEQSHGALHLCC 232
           +  P  +      E    T   +PL             D+ LS L   +    G +HLCC
Sbjct: 123 SCSPEAMRKRQTVEDYPRTGEHQPLKVFIDLCQKESTLDECLSYLCRWIHYRRGLVHLCC 182

Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLK 292
            K+    M   S   +LK +  D IQELE+   C     L +    A  L ++ NLR L 
Sbjct: 183 NKVQNYSMPTSSFRNLLKRVYPDSIQELEIKRKCS----LNKTGKFAPYLSQMSNLRKLF 238

Query: 293 LFY------YKWAFSSWVRRPSSYFFS-QLTMLGHLRKLHLSHSYLVGKLHYILSCLWVP 345
           L +      Y      +V      F       + ++RK+    S +   L ++L CL  P
Sbjct: 239 LAFGYDDELYVSGQQQFVPDLDCPFLCLYYPQMLYIRKI----SNIKEHLEHLLRCLKNP 294

Query: 346 LHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHL 405
           L +   C+  L D D+  LS+    + LK+L L    +      PLG LL  V+ TL+ L
Sbjct: 295 LGTFIFCHAYLADQDMECLSQYPSLSQLKELHLIHILMWTTNLEPLGALLEKVAATLEIL 354

Query: 406 DLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPI 465
            LK C ++D+ L  LLPAL RCS L++     N  S+  L  LL HT GL +L   LYP 
Sbjct: 355 TLKDCQIQDSQLRVLLPALSRCSQLTTFYFRGNETSTNALKDLLCHTGGLSKLGLELYPA 414

Query: 466 PVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
           P++C        RG VN + L  ++AE+   L+ ++Q
Sbjct: 415 PLECLDN-----RGHVNWEILAPIRAELMCTLREVRQ 446


>gi|154800493 PRAME family member 22 [Homo sapiens]
          Length = 481

 Score =  174 bits (441), Expect = 2e-43
 Identities = 145/461 (31%), Positives = 226/461 (49%), Gaps = 31/461 (6%)

Query: 60  MEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQA 119
           M ++  AP  LLELA  SLL ++A    +L++L   LFPPL   AF     + LK +VQA
Sbjct: 1   MRMSLQAPRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQA 60

Query: 120 WPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGK 179
           WPF  L LGSL+ + P+ + L  VVDG++   A +  PR+ +L++L+   D ++ F+   
Sbjct: 61  WPFPCLPLGSLM-KTPDLEILHYVVDGIDCLLAQKVRPRRWKLQVLELR-DVDENFWTIW 118

Query: 180 GASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTK-------------VEQSHG 226
             +  L+  P  +      E    T   +PL  F+   L +             V+   G
Sbjct: 119 SGARPLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRG 178

Query: 227 ALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIF 286
           ++HLCC K+    M++ +   IL+T+  D IQ LE++  C   +++         L ++ 
Sbjct: 179 SVHLCCTKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWPCMIVEFSRY----LSQMR 234

Query: 287 NLRSLKLFYY---KWAFSSWVRRPS-SYFFSQLTMLGHLRKLHLSH-SYLVGKLHYILSC 341
           NLR  KLF     ++  SS  +    + F S L  L +L+ L++    +  G L  ++ C
Sbjct: 235 NLR--KLFISDGCRYLLSSDSQEQLVAEFSSVLLRLEYLQMLYVRRVCFFRGHLDQLIRC 292

Query: 342 LWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGT 401
           L  PL +L +    L   D+  L R    + LK+L+LS   L ++   PL  LL  V+ T
Sbjct: 293 LRSPLETLALTYGFLEKVDLKCLPRYPSLSQLKQLNLSHGALRFIRLEPLRALLEKVAAT 352

Query: 402 LQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQV 461
           LQ L L  C ++D+ L  +LPAL  CS+L++     N  S   L  LL HT  L  L   
Sbjct: 353 LQTLFLVDCGIRDSKLRVILPALSCCSNLTTFCFHGNDTSMDGLKDLLRHTGRLSNLSLE 412

Query: 462 LYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
            YP P +         RG V  + L  LQAE+ + L+ +++
Sbjct: 413 TYPAPRESL-----DDRGRVISELLTPLQAELMRILREVRE 448


>gi|194306638 PRAME family member 3 [Homo sapiens]
          Length = 481

 Score =  174 bits (441), Expect = 2e-43
 Identities = 145/461 (31%), Positives = 226/461 (49%), Gaps = 31/461 (6%)

Query: 60  MEVNHPAPLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQA 119
           M ++  AP  LLELA  SLL ++A    +L++L   LFPPL   AF     + LK +VQA
Sbjct: 1   MRMSLQAPRRLLELAGQSLLGDQALAISILDELPRELFPPLFVEAFTSRRCEVLKVMVQA 60

Query: 120 WPFRFLHLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGK 179
           WPF  L LGSL+ + P+ + L  VVDG++   A +  PR+ +L++L+   D ++ F+   
Sbjct: 61  WPFPCLPLGSLM-KTPDLEILHYVVDGIDCLLAQKVRPRRRKLQVLELR-DVDENFWTIW 118

Query: 180 GASEALAKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTK-------------VEQSHG 226
             +  L+  P  +      E    T   +PL  F+   L +             V+   G
Sbjct: 119 SGARPLSCSPEAMSKRQTVEDCPRTGEKQPLKVFMDVCLKEKFMDEDLSFFSGWVQHRRG 178

Query: 227 ALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIF 286
           ++HLCC K+    M++ +   IL+T+  D IQ LE++  C   +++         L ++ 
Sbjct: 179 SVHLCCTKVVNYSMSILNFRNILETVYPDSIQVLEIWNMCWPCMIVEFIRY----LSQMR 234

Query: 287 NLRSLKLFYY---KWAFSSWVRRPS-SYFFSQLTMLGHLRKLHLSH-SYLVGKLHYILSC 341
           NLR  KLF     ++  SS  +    + F S L  L +L+ L++    +  G L  ++ C
Sbjct: 235 NLR--KLFISDGCRYLLSSDSQEQLVAEFSSVLLRLEYLQMLYVRRVCFFRGHLDQLIRC 292

Query: 342 LWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGT 401
           L  PL +L +    L   D+  L R    + LK+L+LS   L ++   PL  LL  V+ T
Sbjct: 293 LRSPLETLALTYGFLEKVDLKCLPRYPSLSQLKQLNLSHGALRFIRLEPLRALLEKVAAT 352

Query: 402 LQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQV 461
           LQ L L  C ++D+ L  +LPAL  CS+L++     N  S   L  LL HT  L  L   
Sbjct: 353 LQTLFLVDCGIRDSKLRVILPALSCCSNLTTFCFHGNDTSMDGLKDLLRHTGRLSNLSLE 412

Query: 462 LYPIPVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
            YP P +         RG V  + L  LQAE+ + L+ +++
Sbjct: 413 TYPAPRESL-----DDRGRVISELLTPLQAELMRILREVRE 448


>gi|7661860 leucine rich repeat containing 14 [Homo sapiens]
          Length = 493

 Score =  171 bits (433), Expect = 1e-42
 Identities = 157/497 (31%), Positives = 222/497 (44%), Gaps = 77/497 (15%)

Query: 69  SLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFLHLG 128
           +L+ L+   +L  + +    L  L   LFP L   AF       L+ LV  WPF  L   
Sbjct: 3   TLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKTVVLRELVHTWPFPLLSFQ 62

Query: 129 SLIVQW-----------PNQDSLQAVVDGLEAFSAHRACP--------RKSELRMLDFT- 168
            L+ +            P+ +S+QAV+ GL A   H + P        RK  LR+LD T 
Sbjct: 63  QLLQECAHCSRALLQERPSTESMQAVILGLTA-RLHTSEPGASTQPLCRKHALRVLDMTG 121

Query: 169 -LDSEQVFYCGKGASEALAKFPFWLPSAVKAETPQA-----TARPKPLD----------- 211
            LD         G  +       W  +A  A T  A      A P P             
Sbjct: 122 LLDD--------GVEQDPGTMSMWDCTAAVARTCIAQQQGGAAEPGPAPIPVEVRVDLRV 173

Query: 212 -----KFLSDLLTKVEQSHGALHLCCRKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWC 266
                 FL + L     S   L LCCR L  E + + + + +L+ L    ++ +++    
Sbjct: 174 NRASYAFLREALRSSVGS--PLRLCCRDLRAEDLPMRNTVALLQLLDAGCLRRVDL---- 227

Query: 267 RDFLVLAEPNLSAI--QLGRIFNLRSLKLFYYKWAFSSWVRRPS-------SYFFSQLTM 317
             F  L    LS I   + R  +L SL+L Y         R+PS        YF +Q+  
Sbjct: 228 -RFNNLGLRGLSVIIPHVARFQHLASLRLHYVHGDS----RQPSVDGEDNFRYFLAQMGR 282

Query: 318 LGHLRKLHLSHSYLVGKLHYILSCLWVPLHSLEICNCKLLDTDITYLSRSHHTTCLKKLD 377
              LR+L +  S L G+L  +LS L  PL SLE+  C LL  D+ +L+RS H   LKKLD
Sbjct: 283 FTCLRELSMGSSLLSGRLDQLLSTLQSPLESLELAFCALLPEDLRFLARSPHAAHLKKLD 342

Query: 378 LSVNDLSYMIPGPLGTLLRAVSGTLQHLDLKHCWLKDAHLSALLPALCRCSHLSSLSLSD 437
           LS NDLS     P   LL+A + TL HL+L  C L D  L A LP L +C+ L  L L  
Sbjct: 343 LSGNDLSGSQLAPFQGLLQASAATLLHLELTECQLADTQLLATLPILTQCASLRYLGLYG 402

Query: 438 NPISSACLLSLLEHTMGLMELKQVLYPIPVDCCIYL------HGVCRGPVNEDKLCQLQA 491
           NP+S A L  LL  ++   EL+ V++P PVDC   L        +    +NE+K  +++A
Sbjct: 403 NPLSMAGLKELLRDSVAQAELRTVVHPFPVDCYEGLPWPPPASVLLEASINEEKFARVEA 462

Query: 492 EIQKQLQAMQQADMQWS 508
           E+ + L A  +A + W+
Sbjct: 463 ELHQLLLASGRAHVLWT 479


>gi|194018546 PRAME family member 10 [Homo sapiens]
          Length = 474

 Score =  169 bits (429), Expect = 4e-42
 Identities = 145/457 (31%), Positives = 220/457 (48%), Gaps = 35/457 (7%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           AP  LLELA  SLL N+      L++L   +FP +   AF+    +ALK +VQAWPF  L
Sbjct: 5   APSRLLELAGQSLLRNQFLTIFTLDELPREVFPLMFMEAFSMRRFEALKLMVQAWPFLSL 64

Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
            LGSL+ +  + ++LQAV+ GL+   A +  PR+ +L++LD   D ++ F+     +  L
Sbjct: 65  PLGSLM-KTLHLETLQAVLRGLDTLVAQKVRPRRWKLQVLDLR-DVDENFWTIWSGARVL 122

Query: 186 AKFPFWLPSAVKAETPQATARPKPL-------------DKFLSDLLTKVEQSHGALHLCC 232
           +  P  +      E        +PL             D+ LS L   +    G +HLCC
Sbjct: 123 SCSPEAMSKRQTVEDCPRMGEHQPLKVFIDLCLKESTLDECLSYLFGWIHYRRGLVHLCC 182

Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEVFYWCRDFLVLAEPNLSAIQLGRIFNLRSLK 292
            K+    M   S   +L+ +  D IQELEV+  C     L +    A  L ++ NLR L 
Sbjct: 183 SKVQNYSMPTSSFRNLLERIYPDSIQELEVWKKCS----LNKTGKFAPYLSQMSNLRELF 238

Query: 293 L-FYYKWAFSSWVRRP------SSYFFSQLTMLGHLRKLHLSHSYLVGKLHYILSCLWVP 345
           L F Y+      V+ P      S +       + +++K+    S +   L ++L  L  P
Sbjct: 239 LAFGYERELYVSVQWPCIPDLDSPFLCLYYPQMLYIKKI----SNIKEHLEHLLRYLKNP 294

Query: 346 LHSLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHL 405
           L +    +  L D D+  LS+    + LK+L L    +      PLG LL  V+ TL+ L
Sbjct: 295 LGAFIFSDAYLTDRDMECLSQYPSLSQLKELRLIHILMWTTHLEPLGVLLEKVAATLKTL 354

Query: 406 DLKHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPI 465
            LK C ++D  L  LLPAL  CS L++ +   N  S   L  LL HT GL +L   LYP 
Sbjct: 355 VLKDCRIQDPQLRVLLPALSHCSQLTTFNFHGNETSMNALKDLLRHTGGLSKLGLELYPA 414

Query: 466 PVDCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
           P++   Y     +G VN + L  ++AE+ + L+ ++Q
Sbjct: 415 PLESLDY-----KGHVNWEILTPIRAELMRTLREVRQ 446


>gi|12738831 PRAME family member 1 [Homo sapiens]
          Length = 474

 Score =  167 bits (422), Expect = 3e-41
 Identities = 145/455 (31%), Positives = 223/455 (49%), Gaps = 31/455 (6%)

Query: 66  APLSLLELAAHSLLSNEASVPLVLEQLTVNLFPPLLTAAFAKGHRKALKALVQAWPFRFL 125
           AP  LLELA  SLL ++A     +E+L   L+ PL   AF++ H + L  +VQAWPF  L
Sbjct: 5   APPRLLELAGQSLLRDQALSISAMEELPRVLYLPLFMEAFSRRHFQTLTVMVQAWPFTCL 64

Query: 126 HLGSLIVQWPNQDSLQAVVDGLEAFSAHRACPRKSELRMLDFTLDSEQVFYCGKGASEAL 185
            LGSL+ +  + ++L+A+++GL      +  PR+ +L++LD   D ++ F+     + AL
Sbjct: 65  PLGSLM-KTLHLETLKALLEGLHMLLTQKDRPRRWKLQVLDLR-DVDENFWARWPGAWAL 122

Query: 186 AKFPFWLPSAVKAETPQATARPKPLDKFLSDLLTKVEQSH-------------GALHLCC 232
           + FP        AE        +PL  F+   L ++ Q               G +HLCC
Sbjct: 123 SCFPETTSKRQTAEDCPRMGEHQPLKVFIDICLKEIPQDECLRYLFQWVYQRRGLVHLCC 182

Query: 233 RKLHIEKMAVDSLLRILKTLRLDFIQELEV--FYWCRDFLVLAEPNLSAIQLGRIFNLRS 290
            KL      +  L + LK + L+ IQELE+    W R    L         L  + NLR 
Sbjct: 183 SKLVNYLTPIKYLRKSLKIIYLNSIQELEIRNMSWPRLIRKLR------CYLKEMKNLRK 236

Query: 291 LKLF--YYKWAFSSWVRRPSSYFFSQLTMLGHLRKLHLSH-SYLVGKLHYILSCLWVPLH 347
           L     ++  + +    R  + F S    L HL+ L +   ++  G L  ++ CL  PL 
Sbjct: 237 LVFSRCHHYTSDNELQGRLVAKFSSVFLRLEHLQLLKIKLITFFSGHLEQLIRCLQNPLE 296

Query: 348 SLEICNCKLLDTDITYLSRSHHTTCLKKLDLSVNDLSYMIPGPLGTLLRAVSGTLQHLDL 407
           +LE+    LL+ D+  LS+      LK L+LS   L  +   PLG LL  ++ +L+ L L
Sbjct: 297 NLELTYGYLLEEDMKCLSQYPSLGYLKHLNLSYVLLFRISLEPLGALLEKIAASLKTLIL 356

Query: 408 KHCWLKDAHLSALLPALCRCSHLSSLSLSDNPISSACLLSLLEHTMGLMELKQVLYPIPV 467
           + C +  + LSA+LPAL RCS L++     N +S   L  LL HT GL +L    YP P 
Sbjct: 357 EGCQIHYSQLSAILPALSRCSQLTTFYFGRNCMSIDALKDLLRHTSGLSKLSLETYPAPE 416

Query: 468 DCCIYLHGVCRGPVNEDKLCQLQAEIQKQLQAMQQ 502
           +    L+ + R  VN +    L+AE+   L+ ++Q
Sbjct: 417 ES---LNSLVR--VNWEIFTPLRAELMCTLREVRQ 446


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.136    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,025,680
Number of Sequences: 37866
Number of extensions: 878835
Number of successful extensions: 3152
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 2906
Number of HSP's gapped (non-prelim): 178
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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