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Search of human proteins with 169215723
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169215723 PREDICTED: ubiquitin specific peptidase 41 [Homo
sapiens]
(346 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169215723 PREDICTED: ubiquitin specific peptidase 41 [Homo sa... 720 0.0
gi|239746654 PREDICTED: ubiquitin specific protease 41 [Homo sap... 686 0.0
gi|239757637 PREDICTED: ubiquitin specific peptidase 41 [Homo sa... 605 e-173
gi|32313610 ubiquitin specific protease 18 [Homo sapiens] 588 e-168
gi|71774197 ubiquitin specific protease 47 [Homo sapiens] 130 2e-30
gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens] 98 9e-21
gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens] 98 9e-21
gi|149192845 ubiquitin specific protease 24 [Homo sapiens] 96 6e-20
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 90 3e-18
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 90 3e-18
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 90 3e-18
gi|150378533 ubiquitin specific peptidase 7 [Homo sapiens] 88 1e-17
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 87 3e-17
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 87 3e-17
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 87 3e-17
gi|110347427 ubiquitin specific protease 34 [Homo sapiens] 86 4e-17
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 84 2e-16
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 84 2e-16
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 79 8e-15
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 79 8e-15
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 79 8e-15
gi|45267835 ubiquitin specific protease 50 [Homo sapiens] 78 1e-14
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 76 4e-14
gi|41055953 ubiquitin thioesterase 40 [Homo sapiens] 76 5e-14
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 74 2e-13
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 73 3e-13
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 71 1e-12
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 71 1e-12
gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens] 71 2e-12
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 70 3e-12
>gi|169215723 PREDICTED: ubiquitin specific peptidase 41 [Homo
sapiens]
Length = 346
Score = 720 bits (1859), Expect = 0.0
Identities = 346/346 (100%), Positives = 346/346 (100%)
Query: 1 MDGVLFRAHQCQYVHPCVHVYVTVGLMDPLCLLPRSWDYRHGLVGLHNIGQTCCLNSLIQ 60
MDGVLFRAHQCQYVHPCVHVYVTVGLMDPLCLLPRSWDYRHGLVGLHNIGQTCCLNSLIQ
Sbjct: 1 MDGVLFRAHQCQYVHPCVHVYVTVGLMDPLCLLPRSWDYRHGLVGLHNIGQTCCLNSLIQ 60
Query: 61 VFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVWPLELAYCLQKYN 120
VFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVWPLELAYCLQKYN
Sbjct: 61 VFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVWPLELAYCLQKYN 120
Query: 121 VPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQALYMIRMKDSLICLDCAMESSRNSSM 180
VPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQALYMIRMKDSLICLDCAMESSRNSSM
Sbjct: 121 VPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQALYMIRMKDSLICLDCAMESSRNSSM 180
Query: 181 LTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQT 240
LTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQT
Sbjct: 181 LTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQT 240
Query: 241 LTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHV 300
LTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHV
Sbjct: 241 LTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHV 300
Query: 301 GMADSGHYCVYIRNAVDGKWFCFNDSNICLVRNIIHNCLLPWIGHL 346
GMADSGHYCVYIRNAVDGKWFCFNDSNICLVRNIIHNCLLPWIGHL
Sbjct: 301 GMADSGHYCVYIRNAVDGKWFCFNDSNICLVRNIIHNCLLPWIGHL 346
>gi|239746654 PREDICTED: ubiquitin specific protease 41 [Homo
sapiens]
Length = 347
Score = 686 bits (1769), Expect = 0.0
Identities = 331/331 (100%), Positives = 331/331 (100%)
Query: 1 MDGVLFRAHQCQYVHPCVHVYVTVGLMDPLCLLPRSWDYRHGLVGLHNIGQTCCLNSLIQ 60
MDGVLFRAHQCQYVHPCVHVYVTVGLMDPLCLLPRSWDYRHGLVGLHNIGQTCCLNSLIQ
Sbjct: 1 MDGVLFRAHQCQYVHPCVHVYVTVGLMDPLCLLPRSWDYRHGLVGLHNIGQTCCLNSLIQ 60
Query: 61 VFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVWPLELAYCLQKYN 120
VFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVWPLELAYCLQKYN
Sbjct: 61 VFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVWPLELAYCLQKYN 120
Query: 121 VPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQALYMIRMKDSLICLDCAMESSRNSSM 180
VPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQALYMIRMKDSLICLDCAMESSRNSSM
Sbjct: 121 VPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQALYMIRMKDSLICLDCAMESSRNSSM 180
Query: 181 LTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQT 240
LTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQT
Sbjct: 181 LTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQT 240
Query: 241 LTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHV 300
LTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHV
Sbjct: 241 LTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHV 300
Query: 301 GMADSGHYCVYIRNAVDGKWFCFNDSNICLV 331
GMADSGHYCVYIRNAVDGKWFCFNDSNICLV
Sbjct: 301 GMADSGHYCVYIRNAVDGKWFCFNDSNICLV 331
>gi|239757637 PREDICTED: ubiquitin specific peptidase 41 [Homo
sapiens]
Length = 344
Score = 605 bits (1561), Expect = e-173
Identities = 294/296 (99%), Positives = 296/296 (100%)
Query: 36 SWDYRHGLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLL 95
SWDYRHGLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLL
Sbjct: 13 SWDYRHGLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLL 72
Query: 96 LEKMQDSRQKAVWPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQA 155
LEKMQDSRQKAVWPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQA
Sbjct: 73 LEKMQDSRQKAVWPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQA 132
Query: 156 LYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKS 215
LYMIR+KDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKS
Sbjct: 133 LYMIRVKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKS 192
Query: 216 KCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILP 275
KCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILP
Sbjct: 193 KCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILP 252
Query: 276 MKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLV 331
MKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIR+AVDGKWFCFNDSNICLV
Sbjct: 253 MKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRSAVDGKWFCFNDSNICLV 308
>gi|32313610 ubiquitin specific protease 18 [Homo sapiens]
Length = 372
Score = 588 bits (1515), Expect = e-168
Identities = 287/298 (96%), Positives = 290/298 (97%)
Query: 34 PRSWDYRHGLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQML 93
PR+WDY HGLVGLHNIGQTCCLNSLIQVFVMNVDF RILKRITVPRGADEQRRSVPFQML
Sbjct: 45 PRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPRGADEQRRSVPFQML 104
Query: 94 LLLEKMQDSRQKAVWPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIADVHLVERL 153
LLLEKMQDSRQKAV PLELAYCLQK NVPLFVQHDAAQLYLKLWNLIKDQI DVHLVERL
Sbjct: 105 LLLEKMQDSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYLKLWNLIKDQITDVHLVERL 164
Query: 154 QALYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSS 213
QALY IR+KDSLIC+DCAMESSRNSSMLTL LS FDVDSKPLKTLEDALHCFFQPRELSS
Sbjct: 165 QALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSS 224
Query: 214 KSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQI 273
KSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQI
Sbjct: 225 KSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQI 284
Query: 274 LPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLV 331
LPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLV
Sbjct: 285 LPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLV 342
>gi|71774197 ubiquitin specific protease 47 [Homo sapiens]
Length = 1287
Score = 130 bits (326), Expect = 2e-30
Identities = 87/339 (25%), Positives = 147/339 (43%), Gaps = 52/339 (15%)
Query: 42 GLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQD 101
G VGL N TC LNSL+Q M +F L + ++ S+P+Q+ L +Q
Sbjct: 98 GYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQT 157
Query: 102 SRQKAVWPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQALYMIRM 161
S+++A+ ++ + + QHD +L +++ ++ + + + LY ++
Sbjct: 158 SKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKL 217
Query: 162 KDSLICLDCAMESSRNSSMLTLRLSFFDV-DSKPLKTLEDALHCFFQPRELSSKSKCFCE 220
KD + CL+C E R + L + L S+ ++E+ALH F QP L ++ FCE
Sbjct: 218 KDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCE 277
Query: 221 NCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTR--KICHSLYFPQSLDFSQILPMKR 278
C KK ++ L+ H P LT+ L RF + K+ + FP+ LD S + ++
Sbjct: 278 RCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSTFIDVED 337
Query: 279 E-----------------SCDAEEQSGG-------------------------------- 289
E SC +++ S
Sbjct: 338 EKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVDEGICLETNSGTEKISKSGLEKNSL 397
Query: 290 QYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNI 328
YELF+V+ H G A GHY I++ D +W+ FND ++
Sbjct: 398 IYELFSVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHV 436
>gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens]
Length = 485
Score = 98.2 bits (243), Expect = 9e-21
Identities = 81/308 (26%), Positives = 138/308 (44%), Gaps = 37/308 (12%)
Query: 40 RHGLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRIT-----------VPRGADEQRRSV 88
++ VGL N+G TC +N+ +QV+ +N++ + L + D + +++
Sbjct: 85 KNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEKDYEPQTI 144
Query: 89 PFQMLLLLEKMQDSRQKAVWPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIA--- 145
+ L +Q+S ++ + P L + Q DA + +L++D ++
Sbjct: 145 CEHLQYLFALLQNSNRRYIDPSGFVKAL---GLDTGQQQDAQEFSKLFMSLLEDTLSKQK 201
Query: 146 --DVHLVERLQALYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALH 203
DV + +Q + +C C ES S L L+ + K L D +
Sbjct: 202 NPDVRNI--VQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNI-----QGHKQLTDCIS 254
Query: 204 CFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLY 263
F + +L ++ FCENC K + ++L LP TL + LMRF R+ H
Sbjct: 255 EFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVF----DRQTGHKKK 310
Query: 264 FPQSLDFSQILPMKRESCDAEEQSGGQ--YELFAVIAHVGM-ADSGHYCVYIRNAVDGKW 320
+ FS+IL M+ E GG YEL AV+ H G+ A SGHY ++++ G+W
Sbjct: 311 LNTYIGFSEILDME----PYVEHKGGSYVYELSAVLIHRGVSAYSGHYIAHVKDPQSGEW 366
Query: 321 FCFNDSNI 328
+ FND +I
Sbjct: 367 YKFNDEDI 374
>gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]
Length = 1035
Score = 98.2 bits (243), Expect = 9e-21
Identities = 81/308 (26%), Positives = 138/308 (44%), Gaps = 37/308 (12%)
Query: 40 RHGLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRIT-----------VPRGADEQRRSV 88
++ VGL N+G TC +N+ +QV+ +N++ + L + D + +++
Sbjct: 85 KNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYMLGDGIQEEKDYEPQTI 144
Query: 89 PFQMLLLLEKMQDSRQKAVWPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIA--- 145
+ L +Q+S ++ + P L + Q DA + +L++D ++
Sbjct: 145 CEHLQYLFALLQNSNRRYIDPSGFVKAL---GLDTGQQQDAQEFSKLFMSLLEDTLSKQK 201
Query: 146 --DVHLVERLQALYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALH 203
DV + +Q + +C C ES S L L+ + K L D +
Sbjct: 202 NPDVRNI--VQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNI-----QGHKQLTDCIS 254
Query: 204 CFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLY 263
F + +L ++ FCENC K + ++L LP TL + LMRF R+ H
Sbjct: 255 EFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVF----DRQTGHKKK 310
Query: 264 FPQSLDFSQILPMKRESCDAEEQSGGQ--YELFAVIAHVGM-ADSGHYCVYIRNAVDGKW 320
+ FS+IL M+ E GG YEL AV+ H G+ A SGHY ++++ G+W
Sbjct: 311 LNTYIGFSEILDME----PYVEHKGGSYVYELSAVLIHRGVSAYSGHYIAHVKDPQSGEW 366
Query: 321 FCFNDSNI 328
+ FND +I
Sbjct: 367 YKFNDEDI 374
>gi|149192845 ubiquitin specific protease 24 [Homo sapiens]
Length = 2460
Score = 95.5 bits (236), Expect = 6e-20
Identities = 84/315 (26%), Positives = 130/315 (41%), Gaps = 35/315 (11%)
Query: 42 GLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQD 101
G VGL N G TC +N++ Q M L ++V D SV +Q+ L + +
Sbjct: 1527 GFVGLRNGGATCYMNAVFQQLYMQPGLPESL--LSVDDDTDNPDDSVFYQVQSLFGHLME 1584
Query: 102 SRQKAVWPLELAYCLQKYNVPLFV--QHDAAQLYLKLWNLIKDQIADVHLVERLQALYMI 159
S+ + P + +N L+V Q DA + + L + + + + + + + +
Sbjct: 1585 SKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQG 1644
Query: 160 RMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFC 219
D IC DC R + + L L S LE +L F + L + +C
Sbjct: 1645 IYSDQKICKDCPHRYEREEAFMALNLGVTSCQS-----LEISLDQFVRGEVLEGSNAYYC 1699
Query: 220 ENCGKKTRGKQVLKLTHLPQTLTIHLMRFSI--RNSQTRKICHSLYFPQSLDFS--QILP 275
E C +K + + LP L IHLMRF + ++ K + FP L+ +
Sbjct: 1700 EKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSG 1759
Query: 276 MKRESCDAE--------EQSGG-----------QYELFAVIAHVGMADSGHYCVYI---R 313
M R+ +E +Q GG YEL VI H G A +GHY +I R
Sbjct: 1760 MARQDSSSEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRR 1819
Query: 314 NAVDGKWFCFNDSNI 328
GKW+ FND+ I
Sbjct: 1820 GCGKGKWYKFNDTVI 1834
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 89.7 bits (221), Expect = 3e-18
Identities = 75/323 (23%), Positives = 135/323 (41%), Gaps = 47/323 (14%)
Query: 43 LVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQ-----RRSVPFQMLLLLE 97
L GL N+G TC +NS++Q A R + + V + ++++
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
Query: 98 KMQDSRQKAVWPLELAYCLQKYNVPL--FVQHDAAQLYLKLWNLI--------------- 140
+ + + + P + + K N + Q D+ +L L L + +
Sbjct: 836 ALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKE 895
Query: 141 --KDQIADVHLVER------------LQALYMIRMKDSLICLDCAMESSRNSSMLTLRLS 186
D + D E + AL+ + K ++ CL C +S + + L L
Sbjct: 896 ENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLP 955
Query: 187 FFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLM 246
+ S TL+D L F + +L+ ++ +C +C + + +++ LP L +HL
Sbjct: 956 ---LASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLK 1012
Query: 247 RFSIRNSQTRKICHSLYFP-QSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADS 305
RFS +K+ S+ FP ++LD SQ + + + +Y LF+V H G D
Sbjct: 1013 RFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLK-------KYNLFSVSNHYGGLDG 1065
Query: 306 GHYCVYIRNAVDGKWFCFNDSNI 328
GHY Y +NA +WF F+D +
Sbjct: 1066 GHYTAYCKNAARQRWFKFDDHEV 1088
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 89.7 bits (221), Expect = 3e-18
Identities = 75/323 (23%), Positives = 135/323 (41%), Gaps = 47/323 (14%)
Query: 43 LVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQ-----RRSVPFQMLLLLE 97
L GL N+G TC +NS++Q A R + + V + ++++
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
Query: 98 KMQDSRQKAVWPLELAYCLQKYNVPL--FVQHDAAQLYLKLWNLI--------------- 140
+ + + + P + + K N + Q D+ +L L L + +
Sbjct: 836 ALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKE 895
Query: 141 --KDQIADVHLVER------------LQALYMIRMKDSLICLDCAMESSRNSSMLTLRLS 186
D + D E + AL+ + K ++ CL C +S + + L L
Sbjct: 896 ENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLP 955
Query: 187 FFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLM 246
+ S TL+D L F + +L+ ++ +C +C + + +++ LP L +HL
Sbjct: 956 ---LASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLK 1012
Query: 247 RFSIRNSQTRKICHSLYFP-QSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADS 305
RFS +K+ S+ FP ++LD SQ + + + +Y LF+V H G D
Sbjct: 1013 RFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLK-------KYNLFSVSNHYGGLDG 1065
Query: 306 GHYCVYIRNAVDGKWFCFNDSNI 328
GHY Y +NA +WF F+D +
Sbjct: 1066 GHYTAYCKNAARQRWFKFDDHEV 1088
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 89.7 bits (221), Expect = 3e-18
Identities = 75/323 (23%), Positives = 135/323 (41%), Gaps = 47/323 (14%)
Query: 43 LVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQ-----RRSVPFQMLLLLE 97
L GL N+G TC +NS++Q A R + + V + ++++
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMK 835
Query: 98 KMQDSRQKAVWPLELAYCLQKYNVPL--FVQHDAAQLYLKLWNLI--------------- 140
+ + + + P + + K N + Q D+ +L L L + +
Sbjct: 836 ALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKE 895
Query: 141 --KDQIADVHLVER------------LQALYMIRMKDSLICLDCAMESSRNSSMLTLRLS 186
D + D E + AL+ + K ++ CL C +S + + L L
Sbjct: 896 ENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLP 955
Query: 187 FFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLM 246
+ S TL+D L F + +L+ ++ +C +C + + +++ LP L +HL
Sbjct: 956 ---LASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLK 1012
Query: 247 RFSIRNSQTRKICHSLYFP-QSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADS 305
RFS +K+ S+ FP ++LD SQ + + + +Y LF+V H G D
Sbjct: 1013 RFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLK-------KYNLFSVSNHYGGLDG 1065
Query: 306 GHYCVYIRNAVDGKWFCFNDSNI 328
GHY Y +NA +WF F+D +
Sbjct: 1066 GHYTAYCKNAARQRWFKFDDHEV 1088
>gi|150378533 ubiquitin specific peptidase 7 [Homo sapiens]
Length = 1102
Score = 88.2 bits (217), Expect = 1e-17
Identities = 77/294 (26%), Positives = 124/294 (42%), Gaps = 19/294 (6%)
Query: 36 SWDYRH--GLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQML 93
+WD + G VGL N G TC +NSL+Q + + +P D+ +SVP +
Sbjct: 204 AWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAV--YMMPTEGDDSSKSVPLALQ 261
Query: 94 LLLEKMQDSRQKAVWPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIADVHLVERL 153
+ ++Q S K V +L + F+QHD +L L + +++++ + +
Sbjct: 262 RVFYELQHS-DKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTI 320
Query: 154 QALYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSS 213
L+ +M + C + S R ++LS K K + ++ + +L
Sbjct: 321 PKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSI-----KGKKNIFESFVDYVAVEQLDG 375
Query: 214 KSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSI--RNSQTRKICHSLYFPQSLDFS 271
+K G + K V LT LP L + LMRF + Q KI FP+ L
Sbjct: 376 DNKYDAGEHGLQEAEKGVKFLT-LPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLD 434
Query: 272 QILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFND 325
+ L + + Y L AV+ H G GHY VY+ DGKW F+D
Sbjct: 435 EFLQK------TDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDD 482
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 86.7 bits (213), Expect = 3e-17
Identities = 49/142 (34%), Positives = 72/142 (50%), Gaps = 5/142 (3%)
Query: 194 PLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNS 253
P+ TLED L FF EL + CE C K G + K+ LP+ L IHL RF
Sbjct: 535 PVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVM 594
Query: 254 QTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIR 313
+ KI + FP L+ + P + C ++ + Y+L +VI H G A SGHY Y +
Sbjct: 595 YSFKINSHVSFP--LEGLDLRPFLAKECTSQITT---YDLLSVICHHGTAGSGHYIAYCQ 649
Query: 314 NAVDGKWFCFNDSNICLVRNII 335
N ++G+W+ F+D + V +
Sbjct: 650 NVINGQWYEFDDQYVTEVHETV 671
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 86.7 bits (213), Expect = 3e-17
Identities = 49/142 (34%), Positives = 72/142 (50%), Gaps = 5/142 (3%)
Query: 194 PLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNS 253
P+ TLED L FF EL + CE C K G + K+ LP+ L IHL RF
Sbjct: 535 PVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVM 594
Query: 254 QTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIR 313
+ KI + FP L+ + P + C ++ + Y+L +VI H G A SGHY Y +
Sbjct: 595 YSFKINSHVSFP--LEGLDLRPFLAKECTSQITT---YDLLSVICHHGTAGSGHYIAYCQ 649
Query: 314 NAVDGKWFCFNDSNICLVRNII 335
N ++G+W+ F+D + V +
Sbjct: 650 NVINGQWYEFDDQYVTEVHETV 671
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 86.7 bits (213), Expect = 3e-17
Identities = 49/142 (34%), Positives = 72/142 (50%), Gaps = 5/142 (3%)
Query: 194 PLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNS 253
P+ TLED L FF EL + CE C K G + K+ LP+ L IHL RF
Sbjct: 535 PVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVM 594
Query: 254 QTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIR 313
+ KI + FP L+ + P + C ++ + Y+L +VI H G A SGHY Y +
Sbjct: 595 YSFKINSHVSFP--LEGLDLRPFLAKECTSQITT---YDLLSVICHHGTAGSGHYIAYCQ 649
Query: 314 NAVDGKWFCFNDSNICLVRNII 335
N ++G+W+ F+D + V +
Sbjct: 650 NVINGQWYEFDDQYVTEVHETV 671
>gi|110347427 ubiquitin specific protease 34 [Homo sapiens]
Length = 3546
Score = 86.3 bits (212), Expect = 4e-17
Identities = 77/325 (23%), Positives = 132/325 (40%), Gaps = 39/325 (12%)
Query: 34 PRSWDY--------RHGLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQR 85
P WDY VGL N+G TC L S IQ M + + + T D +
Sbjct: 1876 PYKWDYWPHEDVRAECRFVGLTNLGATCYLASTIQQLYMIPEARQAV--FTAKYSEDMKH 1933
Query: 86 RSVPFQMLLLLEKMQDSRQKAVWPLELA--YCLQKYNVPLFVQHDAAQLYLKLWNLIKDQ 143
++ ++ + + +S KA P Y + K + Q D + + L I++
Sbjct: 1934 KTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQKDMTEFFTDLITKIEEM 1993
Query: 144 IADVHLVERLQALYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALH 203
+ L +++L+ + ++++ LDC S T+R D +K + ++L
Sbjct: 1994 SPE--LKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVRCQVAD-----MKNIYESLD 2046
Query: 204 CFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMR--FSIRNSQTRKICHS 261
L + C +CGKK R ++ LP+ L+ + MR F++ K+
Sbjct: 2047 EVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTH 2106
Query: 262 LYFPQSLDFSQILP------------MKRESCDAEEQSGGQYELFAVIAHVGMADSGHYC 309
FP LD + K S +++ +Y+L V H G AD GHY
Sbjct: 2107 FSFPLRLDMTPYTEDFLMGKSERKEGFKEVSDHSKDSESYEYDLIGVTVHTGTADGGHYY 2166
Query: 310 VYIRNAV------DGKWFCFNDSNI 328
+IR+ V + KW+ FND+ +
Sbjct: 2167 SFIRDIVNPHAYKNNKWYLFNDAEV 2191
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 83.6 bits (205), Expect = 2e-16
Identities = 84/325 (25%), Positives = 129/325 (39%), Gaps = 49/325 (15%)
Query: 42 GLVGLHNIGQTCCLNSLIQVF-----VMNVDFARILKRITVPRGADEQRRSVPFQMLLLL 96
GL GL N+G TC +NS++Q + + R+ R + G++ V L+
Sbjct: 56 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMR-DLHHGSNAHTALVEEFAKLIQ 114
Query: 97 EKMQDSRQKAVWPLELAYCLQKYNVPLFV---QHDAAQLYLKLWNLIKDQIADV------ 147
S V P E +Q+Y P FV Q DA + L + + +++ V
Sbjct: 115 TIWTSSPNDVVSPSEFKTQIQRY-APRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKS 173
Query: 148 ------HLVE-----------------RLQALYMIRMKDSLICLDCAMESSRNSSMLTLR 184
HL + R+ L++ ++K SL C DC S+ L
Sbjct: 174 NPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLS 233
Query: 185 LSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIH 244
L P TL D + F + L K C C + R + + P+ L +H
Sbjct: 234 LPIAK-RGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLH 292
Query: 245 LMRFSIRNSQTRKICHSLYFP-QSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMA 303
L RFS +T K+ + FP + LD + +E + Y L+AV H G
Sbjct: 293 LKRFSESRIRTSKLTTFVNFPLRDLDLREFA--------SENTNHAVYNLYAVSNHSGTT 344
Query: 304 DSGHYCVYIRNAVDGKWFCFNDSNI 328
GHY Y R+ G+W FNDS++
Sbjct: 345 MGGHYTAYCRSPGTGEWHTFNDSSV 369
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 83.6 bits (205), Expect = 2e-16
Identities = 84/325 (25%), Positives = 129/325 (39%), Gaps = 49/325 (15%)
Query: 42 GLVGLHNIGQTCCLNSLIQVF-----VMNVDFARILKRITVPRGADEQRRSVPFQMLLLL 96
GL GL N+G TC +NS++Q + + R+ R + G++ V L+
Sbjct: 265 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMR-DLHHGSNAHTALVEEFAKLIQ 323
Query: 97 EKMQDSRQKAVWPLELAYCLQKYNVPLFV---QHDAAQLYLKLWNLIKDQIADV------ 147
S V P E +Q+Y P FV Q DA + L + + +++ V
Sbjct: 324 TIWTSSPNDVVSPSEFKTQIQRY-APRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKS 382
Query: 148 ------HLVE-----------------RLQALYMIRMKDSLICLDCAMESSRNSSMLTLR 184
HL + R+ L++ ++K SL C DC S+ L
Sbjct: 383 NPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLS 442
Query: 185 LSFFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIH 244
L P TL D + F + L K C C + R + + P+ L +H
Sbjct: 443 LPIAK-RGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLH 501
Query: 245 LMRFSIRNSQTRKICHSLYFP-QSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMA 303
L RFS +T K+ + FP + LD + +E + Y L+AV H G
Sbjct: 502 LKRFSESRIRTSKLTTFVNFPLRDLDLREFA--------SENTNHAVYNLYAVSNHSGTT 553
Query: 304 DSGHYCVYIRNAVDGKWFCFNDSNI 328
GHY Y R+ G+W FNDS++
Sbjct: 554 MGGHYTAYCRSPGTGEWHTFNDSSV 578
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 78.6 bits (192), Expect = 8e-15
Identities = 46/135 (34%), Positives = 68/135 (50%), Gaps = 5/135 (3%)
Query: 194 PLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNS 253
P+ TL+D L FF EL + CE C K G + K+ + P+ L IHL RF
Sbjct: 557 PVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELM 616
Query: 254 QTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIR 313
+ KI + FP L+ + P + A+ + Y+L +VI H G A SGHY Y R
Sbjct: 617 FSTKISTHVSFP--LEGLDLQPFLAKDSPAQIVT---YDLLSVICHHGTASSGHYIAYCR 671
Query: 314 NAVDGKWFCFNDSNI 328
N ++ W+ F+D ++
Sbjct: 672 NNLNNLWYEFDDQSV 686
Score = 31.6 bits (70), Expect = 1.1
Identities = 25/107 (23%), Positives = 44/107 (41%), Gaps = 2/107 (1%)
Query: 42 GLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQD 101
GL GL NIG TC +N+ +Q + D++ + L+ E
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK 242
Query: 102 SRQKAVWPLELAYCLQKYNVPL--FVQHDAAQLYLKLWNLIKDQIAD 146
SR +V P L ++ N + Q DA + L +L+ +++ +
Sbjct: 243 SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 289
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 78.6 bits (192), Expect = 8e-15
Identities = 46/135 (34%), Positives = 68/135 (50%), Gaps = 5/135 (3%)
Query: 194 PLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNS 253
P+ TL+D L FF EL + CE C K G + K+ + P+ L IHL RF
Sbjct: 565 PVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELM 624
Query: 254 QTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIR 313
+ KI + FP L+ + P + A+ + Y+L +VI H G A SGHY Y R
Sbjct: 625 FSTKISTHVSFP--LEGLDLQPFLAKDSPAQIVT---YDLLSVICHHGTASSGHYIAYCR 679
Query: 314 NAVDGKWFCFNDSNI 328
N ++ W+ F+D ++
Sbjct: 680 NNLNNLWYEFDDQSV 694
Score = 31.6 bits (70), Expect = 1.1
Identities = 25/107 (23%), Positives = 44/107 (41%), Gaps = 2/107 (1%)
Query: 42 GLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQD 101
GL GL NIG TC +N+ +Q + D++ + L+ E
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK 242
Query: 102 SRQKAVWPLELAYCLQKYNVPL--FVQHDAAQLYLKLWNLIKDQIAD 146
SR +V P L ++ N + Q DA + L +L+ +++ +
Sbjct: 243 SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 289
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 78.6 bits (192), Expect = 8e-15
Identities = 46/135 (34%), Positives = 68/135 (50%), Gaps = 5/135 (3%)
Query: 194 PLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNS 253
P+ TL+D L FF EL + CE C K G + K+ + P+ L IHL RF
Sbjct: 534 PVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELM 593
Query: 254 QTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIR 313
+ KI + FP L+ + P + A+ + Y+L +VI H G A SGHY Y R
Sbjct: 594 FSTKISTHVSFP--LEGLDLQPFLAKDSPAQIVT---YDLLSVICHHGTASSGHYIAYCR 648
Query: 314 NAVDGKWFCFNDSNI 328
N ++ W+ F+D ++
Sbjct: 649 NNLNNLWYEFDDQSV 663
Score = 31.6 bits (70), Expect = 1.1
Identities = 25/107 (23%), Positives = 44/107 (41%), Gaps = 2/107 (1%)
Query: 42 GLVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADEQRRSVPFQMLLLLEKMQD 101
GL GL NIG TC +N+ +Q + D++ + L+ E
Sbjct: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK 211
Query: 102 SRQKAVWPLELAYCLQKYNVPL--FVQHDAAQLYLKLWNLIKDQIAD 146
SR +V P L ++ N + Q DA + L +L+ +++ +
Sbjct: 212 SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 258
>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
Length = 339
Score = 78.2 bits (191), Expect = 1e-14
Identities = 70/310 (22%), Positives = 125/310 (40%), Gaps = 50/310 (16%)
Query: 42 GLVGLHNIGQTCCLNSLIQV---------FVMNVDFARILKRITVPRGADEQRRSVPFQM 92
G+ GL N+G TCC+N++ Q + + + L++ +P E + +
Sbjct: 42 GVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAFAY-- 99
Query: 93 LLLLEKMQDSRQKAVWPLELAYCLQKYNVPLF---VQHDAAQLYLKLWNLIKDQIADVHL 149
L+ M V P E+ + P F +Q DA + + + N + + + H
Sbjct: 100 --LMTDMWLGDSDCVSP-EIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHY 156
Query: 150 VER----------------------LQALYMIRMKDSLICLDCAMESSRNSSMLTLRLSF 187
R + L+ ++ S++CL C + +N L
Sbjct: 157 SRRRSYEKGSTQRCCRKWITTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVFTVFSLP- 215
Query: 188 FDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMR 247
+ SK +L D L CFFQ L+ ++ C C K ++ P+ + HL R
Sbjct: 216 --IPSKYECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHLKR 273
Query: 248 FSIRNSQTRKICHSLYFP-QSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSG 306
F I+ + RK+ +++P +LD + + C + +Y L AV+ H G D G
Sbjct: 274 FDIQGTTKRKLRTDIHYPLTNLDLTPYI------CSIFRKY-PKYNLCAVVNHFGDLDGG 326
Query: 307 HYCVYIRNAV 316
HY + +N+V
Sbjct: 327 HYTAFCKNSV 336
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 76.3 bits (186), Expect = 4e-14
Identities = 49/141 (34%), Positives = 66/141 (46%), Gaps = 8/141 (5%)
Query: 195 LKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQ 254
+ +L D L F +P L S +K C +C + L + LP HL RF Q
Sbjct: 546 IPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQ 605
Query: 255 TRKICHSLYFPQSLDFSQILPMKRESCDAEEQ-------SGGQYELFAVIAHVGMADSGH 307
RKI + FP LD + L +ES E Q + +Y LFAVI H G +SGH
Sbjct: 606 RRKINTFISFPLELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGH 665
Query: 308 YCVYIRNAVDGKWFCFNDSNI 328
Y +IR D +WF +D+ I
Sbjct: 666 YTSFIRQQKD-QWFSCDDAII 685
>gi|41055953 ubiquitin thioesterase 40 [Homo sapiens]
Length = 1247
Score = 75.9 bits (185), Expect = 5e-14
Identities = 74/293 (25%), Positives = 120/293 (40%), Gaps = 28/293 (9%)
Query: 43 LVGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPR--------GADEQRRSVPFQMLL 94
L G+ N G TC LNSL+Q +F L + D + R +P Q+
Sbjct: 52 LSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDAKVRIIPLQLQR 111
Query: 95 LLEKMQDSRQKAVWPLELAYCLQKYNVPLFVQHDAAQLYLKLWNLIKDQIADVHLVERLQ 154
L ++ Q+A +L + QHD +L L++ ++ + + +
Sbjct: 112 LFAQLLLLDQEAASTADLTDSFGWTSNEEMRQHDVQELNRILFSALETSLVGTSGHDLIY 171
Query: 155 ALYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPRELSSK 214
LY + + ++C +C S R L L ++ +V LEDAL + E+
Sbjct: 172 RLYHGTIVNQIVCKECKNVSERQEDFLDLTVAVKNVSG-----LEDALWNMYVEEEVFDC 226
Query: 215 SKCF-CENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIR--NSQTRKICHSLYFPQSLDFS 271
+ C C + + + KL LP LT+ L+RF+ + K FP ++
Sbjct: 227 DNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVKCERYKETSCYTFPLRINLK 286
Query: 272 QILPMKRESCDAEEQSGGQY--ELFAVIAHVGMADSGHYCVYIRNAVD--GKW 320
C+ E +Y +LF+VI H G GHY VYI++ VD G W
Sbjct: 287 PF-------CEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKD-VDHLGNW 331
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 73.9 bits (180), Expect = 2e-13
Identities = 44/138 (31%), Positives = 65/138 (47%), Gaps = 10/138 (7%)
Query: 193 KPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRN 252
KP L+D + F +L ++ +C NC + + + L L LP L +HL RFS
Sbjct: 754 KPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSR 813
Query: 253 SQTRKICHSLYFP-QSLDFSQILPMKRESCDAEEQSGG-QYELFAVIAHVGMADSGHYCV 310
K+ + FP LD S+ L +G +Y L AV H G GHY
Sbjct: 814 YMRDKLDTLVDFPINDLDMSEFL--------INPNAGPCRYNLIAVSNHYGGMGGGHYTA 865
Query: 311 YIRNAVDGKWFCFNDSNI 328
+ +N DGKW+ F+DS++
Sbjct: 866 FAKNKDDGKWYYFDDSSV 883
Score = 29.3 bits (64), Expect = 5.4
Identities = 12/19 (63%), Positives = 14/19 (73%)
Query: 42 GLVGLHNIGQTCCLNSLIQ 60
GL GL N+G TC +NS IQ
Sbjct: 258 GLCGLSNLGNTCFMNSAIQ 276
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 73.2 bits (178), Expect = 3e-13
Identities = 47/142 (33%), Positives = 65/142 (45%), Gaps = 9/142 (6%)
Query: 195 LKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQ 254
+ TL D L F +P L S +K C +C + L + LP H RF Q
Sbjct: 260 ITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRFEHSAKQ 319
Query: 255 TRKICHSLYFPQSLDFSQILPMKRES-----CDAEEQSG---GQYELFAVIAHVGMADSG 306
RKI + FP LD + + +ES SG +Y LFAV+ H G +SG
Sbjct: 320 RRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESG 379
Query: 307 HYCVYIRNAVDGKWFCFNDSNI 328
HY +IR+ D +WF +D+ I
Sbjct: 380 HYTSFIRHHKD-QWFKCDDAVI 400
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 71.2 bits (173), Expect = 1e-12
Identities = 43/139 (30%), Positives = 64/139 (46%), Gaps = 8/139 (5%)
Query: 193 KPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRN 252
K L D + F L +C NC K + + L LP+ L +HL RFS
Sbjct: 773 KTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNR 832
Query: 253 SQTRKICHSLYFP-QSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVY 311
K+ + FP + L+ S+ + C+ + Y+L AV H G GHY Y
Sbjct: 833 YWRDKLDTVVEFPIRGLNMSEFV------CNLSARPY-VYDLIAVSNHYGAMGVGHYTAY 885
Query: 312 IRNAVDGKWFCFNDSNICL 330
+N ++GKW+ F+DSN+ L
Sbjct: 886 AKNKLNGKWYYFDDSNVSL 904
Score = 30.8 bits (68), Expect = 1.9
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 31 CLLPRSWDYRHGLVGLHNIGQTCCLNSLIQ 60
C P S + GL GL N+G TC +NS +Q
Sbjct: 289 CQEPPSSHIQPGLCGLGNLGNTCFMNSALQ 318
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 71.2 bits (173), Expect = 1e-12
Identities = 43/139 (30%), Positives = 64/139 (46%), Gaps = 8/139 (5%)
Query: 193 KPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRN 252
K L D + F L +C NC K + + L LP+ L +HL RFS
Sbjct: 726 KTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNR 785
Query: 253 SQTRKICHSLYFP-QSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVY 311
K+ + FP + L+ S+ + C+ + Y+L AV H G GHY Y
Sbjct: 786 YWRDKLDTVVEFPIRGLNMSEFV------CNLSARPY-VYDLIAVSNHYGAMGVGHYTAY 838
Query: 312 IRNAVDGKWFCFNDSNICL 330
+N ++GKW+ F+DSN+ L
Sbjct: 839 AKNKLNGKWYYFDDSNVSL 857
Score = 30.8 bits (68), Expect = 1.9
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 31 CLLPRSWDYRHGLVGLHNIGQTCCLNSLIQ 60
C P S + GL GL N+G TC +NS +Q
Sbjct: 242 CQEPPSSHIQPGLCGLGNLGNTCFMNSALQ 271
>gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens]
Length = 2555
Score = 70.9 bits (172), Expect = 2e-12
Identities = 93/389 (23%), Positives = 137/389 (35%), Gaps = 82/389 (21%)
Query: 17 CVHVYVTVGLMDPLCLLPRSWDYR--------HGLVGLHNIGQTCCLNSLIQVFVMNVDF 68
C+ +G C W+Y G VGL N G TC +NS+IQ M
Sbjct: 1524 CLTEMYYMGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSI 1583
Query: 69 ARILKRITVPRG-------ADEQRRSVP--------------FQMLLLLEKMQDSRQKAV 107
+ I DE++ S F+ L K +D ++ +
Sbjct: 1584 RNSILAIEGTGSDLHDDMFGDEKQDSESNVDPRDDVFGYPHQFEDKPALSKTEDRKEYNI 1643
Query: 108 WPLE--------LAYCLQKYNVP---------------LFVQHDAAQLYLKLWNLIKDQI 144
L LA +Y VP L QHDA + + L + + + +
Sbjct: 1644 GVLRHLQVIFGHLAASQLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEAL 1703
Query: 145 ADVHLVERLQALYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHC 204
+ L + D IC C S TL +VD + + L D+L
Sbjct: 1704 KALGHPAILSKVLGGSFADQKICQGCPHRYECEESFTTL-----NVDIRNHQNLLDSLEQ 1758
Query: 205 FFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYF 264
+ + L + CE C KK + L + LP+ L I L RF + I + YF
Sbjct: 1759 YIKGDLLEGANAYHCEKCDKKVDTVKRLLIKKLPRVLAIQLKRFDYDWERECAIKFNDYF 1818
Query: 265 --PQSLDFSQI------------------LPMKRESCDAEEQSGGQYELFAVIAHVGMAD 304
P+ LD L ++E D E G +Y L V+ H G A
Sbjct: 1819 EFPRELDMGPYTVAGVANLERDNVNSENELIEQKEQSDNETAGGTKYRLVGVLVHSGQAS 1878
Query: 305 SGHYCVYI--RNAVDGK---WFCFNDSNI 328
GHY YI RN D + W+ F+D ++
Sbjct: 1879 GGHYYSYIIQRNGKDDQTDHWYKFDDGDV 1907
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 70.1 bits (170), Expect = 3e-12
Identities = 46/140 (32%), Positives = 64/140 (45%), Gaps = 9/140 (6%)
Query: 197 TLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTR 256
TL D L F +P L S +K C C + L + LP HL RF R
Sbjct: 361 TLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRR 420
Query: 257 KICHSLYFPQSLDFSQILPMKRES-CDAEEQ-------SGGQYELFAVIAHVGMADSGHY 308
KI + FP LD + + +ES + + Q + +Y LFAV+ H G +SGHY
Sbjct: 421 KITTYVSFPLELDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESGHY 480
Query: 309 CVYIRNAVDGKWFCFNDSNI 328
+IR D +WF +D+ I
Sbjct: 481 TSFIRQHKD-QWFKCDDAII 499
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.140 0.450
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,735,798
Number of Sequences: 37866
Number of extensions: 532890
Number of successful extensions: 2243
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 1963
Number of HSP's gapped (non-prelim): 214
length of query: 346
length of database: 18,247,518
effective HSP length: 103
effective length of query: 243
effective length of database: 14,347,320
effective search space: 3486398760
effective search space used: 3486398760
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.