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Search of human proteins with 112382372
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112382372 guanylate binding protein 3 [Homo sapiens]
(595 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112382372 guanylate binding protein 3 [Homo sapiens] 1178 0.0
gi|166706903 guanylate binding protein 1, interferon-inducible, ... 1022 0.0
gi|38327558 guanylate binding protein 2, interferon-inducible [H... 895 0.0
gi|197333737 guanylate-binding protein 5 [Homo sapiens] 772 0.0
gi|16418425 guanylate-binding protein 5 [Homo sapiens] 772 0.0
gi|148234215 guanylate binding protein 4-like [Homo sapiens] 647 0.0
gi|31377634 guanylate binding protein 4 [Homo sapiens] 633 0.0
gi|157671915 guanylate binding protein family, member 6 [Homo sa... 615 e-176
gi|45827806 atlastin 3 [Homo sapiens] 71 2e-12
gi|169160863 PREDICTED: similar to guanylate-binding protein 5 [... 70 5e-12
gi|208610002 atlastin GTPase 2 isoform 2 [Homo sapiens] 70 5e-12
gi|208610000 atlastin GTPase 2 isoform 1 [Homo sapiens] 70 5e-12
gi|189181742 atlastin GTPase 1 isoform b [Homo sapiens] 69 1e-11
gi|74024917 atlastin GTPase 1 isoform b [Homo sapiens] 69 1e-11
gi|19923445 atlastin GTPase 1 isoform a [Homo sapiens] 69 1e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 60 6e-09
gi|91208418 transcription elongation regulator 1 isoform 2 [Homo... 55 1e-07
gi|21327715 transcription elongation regulator 1 isoform 1 [Homo... 55 1e-07
gi|81295809 pericentrin [Homo sapiens] 53 7e-07
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 52 1e-06
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 52 1e-06
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 52 1e-06
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 52 2e-06
gi|221139761 zinc finger protein 853 [Homo sapiens] 51 3e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 51 3e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 51 3e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 51 3e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 51 3e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 51 3e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 51 3e-06
>gi|112382372 guanylate binding protein 3 [Homo sapiens]
Length = 595
Score = 1178 bits (3048), Expect = 0.0
Identities = 595/595 (100%), Positives = 595/595 (100%)
Query: 1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 120
KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV
Sbjct: 61 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 120
Query: 121 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL 180
LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL
Sbjct: 121 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL 180
Query: 181 RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI 240
RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI
Sbjct: 181 RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI 240
Query: 241 HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYIN 300
HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYIN
Sbjct: 241 HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYIN 300
Query: 301 AISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER 360
AISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER
Sbjct: 301 AISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER 360
Query: 361 EATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEV 420
EATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEV
Sbjct: 361 EATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEV 420
Query: 421 KAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQIL 480
KAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQIL
Sbjct: 421 KAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQIL 480
Query: 481 TEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQL 540
TEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQL
Sbjct: 481 TEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQL 540
Query: 541 LEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 595
LEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI
Sbjct: 541 LEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 595
>gi|166706903 guanylate binding protein 1, interferon-inducible,
67kDa [Homo sapiens]
Length = 592
Score = 1022 bits (2642), Expect = 0.0
Identities = 514/586 (87%), Positives = 551/586 (94%), Gaps = 2/586 (0%)
Query: 1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MA EIHMTGPMCLIENTNG L+ANPEALKILSAITQP+VVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MASEIHMTGPMCLIENTNGRLMANPEALKILSAITQPMVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 120
K KGFSLGSTV+SHTKGIWMWCVPHPKKP H LVLLDTEGLGDV+KGDNQNDSWIF LAV
Sbjct: 61 KKKGFSLGSTVQSHTKGIWMWCVPHPKKPGHILVLLDTEGLGDVEKGDNQNDSWIFALAV 120
Query: 121 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENE--DSADFVSFFPDFVW 178
LLSST VYNS+GTINQQAMDQLYYVTELTHRIRSKSSPDENENE DSADFVSFFPDFVW
Sbjct: 121 LLSSTFVYNSIGTINQQAMDQLYYVTELTHRIRSKSSPDENENEVEDSADFVSFFPDFVW 180
Query: 179 TLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDL 238
TLRDFSLDLEADGQPLTPDEYL YSLKL +GTSQKD+ FNLPRLCIRKFFPKKKCFVFD
Sbjct: 181 TLRDFSLDLEADGQPLTPDEYLTYSLKLKKGTSQKDETFNLPRLCIRKFFPKKKCFVFDR 240
Query: 239 PIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTY 298
P+HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGI+VNGPRLESLVLTY
Sbjct: 241 PVHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIQVNGPRLESLVLTY 300
Query: 299 INAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVS 358
+NAIS GDLPCMENAVLALAQIENSAAVQKAIAHY+QQMGQKVQLP ETLQELLDLHR S
Sbjct: 301 VNAISSGDLPCMENAVLALAQIENSAAVQKAIAHYEQQMGQKVQLPTETLQELLDLHRDS 360
Query: 359 EREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEE 418
EREA EV++++SFKDVDHLFQK+LAAQL+KKRDDFCKQNQEASSDRCSALLQVIFSPLEE
Sbjct: 361 EREAIEVFIRSSFKDVDHLFQKELAAQLEKKRDDFCKQNQEASSDRCSALLQVIFSPLEE 420
Query: 419 EVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQ 478
EVKAGIYSKPGGY LF+QKLQDL+KKYYEEPRKGIQAEEILQTYLKSKES+TDAILQTDQ
Sbjct: 421 EVKAGIYSKPGGYRLFVQKLQDLKKKYYEEPRKGIQAEEILQTYLKSKESMTDAILQTDQ 480
Query: 479 ILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERA 538
LTEKEKEIEVE VKAESAQASAKM++EMQ K +QMME+KE+SYQEH+KQLTEKME +R
Sbjct: 481 TLTEKEKEIEVERVKAESAQASAKMLQEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRV 540
Query: 539 QLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKK 584
QLL+EQE+TL KLQEQ ++LKE Q ES ++NEIQ LQ ++++
Sbjct: 541 QLLKEQERTLALKLQEQEQLLKEGFQKESRIMKNEIQDLQTKMRRR 586
>gi|38327558 guanylate binding protein 2, interferon-inducible [Homo
sapiens]
Length = 591
Score = 895 bits (2313), Expect = 0.0
Identities = 443/582 (76%), Positives = 510/582 (87%)
Query: 1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MAPEI++ GPM LI+NT G+LV NPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 120
K GFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGD++KGDN+NDSWIF LA+
Sbjct: 61 KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI 120
Query: 121 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL 180
LLSST VYNSMGTINQQAMDQL+YVTELT RI++ SSP N +DSADFVSFFP FVWTL
Sbjct: 121 LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTL 180
Query: 181 RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI 240
RDF+L+LE DG+P+T D+YLE SLKL +GT +K K+FN PRLCIRKFFPK+KCFVFD P
Sbjct: 181 RDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA 240
Query: 241 HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYIN 300
++ LA LE+L++EEL+P+F++QVA+FCSYI S+S KTLSGGI VNGPRLESLVLTY+N
Sbjct: 241 PKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVN 300
Query: 301 AISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER 360
AIS GDLPCMENAVLALAQIENSAAV+KAIAHY+QQMGQKVQLP ETLQELLDLHR SER
Sbjct: 301 AISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSER 360
Query: 361 EATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEV 420
EA EV+MKNSFKDVD +FQ+KL AQL+ +RDDFCKQN +ASSD C ALLQ IF PLEE+V
Sbjct: 361 EAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDV 420
Query: 421 KAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQIL 480
K G +SKPGGY LF QKLQ+L+ KYY+ PRKGIQA+E+L+ YL+SKE V DA+LQTDQ L
Sbjct: 421 KQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSL 480
Query: 481 TEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQL 540
+EKEK IEVE +KAESA+A+ KM+EE+Q K ++MME+KEKSYQEHVKQLTEKMER+RAQL
Sbjct: 481 SEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQL 540
Query: 541 LEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLK 582
+ EQEKTL KLQEQ R+LKE + ES +LQ +I +Q K
Sbjct: 541 MAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSK 582
>gi|197333737 guanylate-binding protein 5 [Homo sapiens]
Length = 586
Score = 772 bits (1994), Expect = 0.0
Identities = 396/581 (68%), Positives = 469/581 (80%), Gaps = 4/581 (0%)
Query: 1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MA EIHM+ PMCLIEN N +L N EAL+ILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 120
KNKGFS+ STV+SHTKGIW+WCVPHP P HTLVLLDTEGLGDV+K DN+ND IF LA+
Sbjct: 61 KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120
Query: 121 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL 180
LLSST VYN++ I+Q A+D L+ VTELT +++++SPD + ED AD SFFPD VWTL
Sbjct: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180
Query: 181 RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI 240
RDF L LE DGQ +TPDEYLE SL+ QG+ Q+ +NFNLPRLCI+KFFPKKKCF+FDLP
Sbjct: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240
Query: 241 HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYIN 300
H++KLAQLE L D+EL+PEFVQQV +FCSYIFS+S TKTL GGI VNG RL++LVLTY+N
Sbjct: 241 HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN 300
Query: 301 AISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER 360
AIS GDLPC+ENAVLALAQ ENSAAVQKAIAHYDQQMGQKVQLP ETLQELLDLHR SER
Sbjct: 301 AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER 360
Query: 361 EATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEV 420
EA EV+MKNSFKDVD FQK+L LD K++D CK+N EASSD CSALL+ IF PLEE V
Sbjct: 361 EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV 420
Query: 421 KAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQIL 480
K GIYSKPGG+ LFIQK ++L+ KYY EPRKGIQAEE+LQ YLKSKESV+ AILQTDQ L
Sbjct: 421 KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
Query: 481 TEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQL 540
TE EK+ + VKAE+ +A A+ + +Q + +QMM+E+E+ +QE V+Q ME +
Sbjct: 481 TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQNW 536
Query: 541 LEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTL 581
L EQ+K ++QEQA L Q ++ L +E+Q Q+T+
Sbjct: 537 LAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
>gi|16418425 guanylate-binding protein 5 [Homo sapiens]
Length = 586
Score = 772 bits (1994), Expect = 0.0
Identities = 396/581 (68%), Positives = 469/581 (80%), Gaps = 4/581 (0%)
Query: 1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MA EIHM+ PMCLIEN N +L N EAL+ILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 120
KNKGFS+ STV+SHTKGIW+WCVPHP P HTLVLLDTEGLGDV+K DN+ND IF LA+
Sbjct: 61 KNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALAL 120
Query: 121 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL 180
LLSST VYN++ I+Q A+D L+ VTELT +++++SPD + ED AD SFFPD VWTL
Sbjct: 121 LLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTL 180
Query: 181 RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI 240
RDF L LE DGQ +TPDEYLE SL+ QG+ Q+ +NFNLPRLCI+KFFPKKKCF+FDLP
Sbjct: 181 RDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPA 240
Query: 241 HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYIN 300
H++KLAQLE L D+EL+PEFVQQV +FCSYIFS+S TKTL GGI VNG RL++LVLTY+N
Sbjct: 241 HQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVN 300
Query: 301 AISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER 360
AIS GDLPC+ENAVLALAQ ENSAAVQKAIAHYDQQMGQKVQLP ETLQELLDLHR SER
Sbjct: 301 AISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSER 360
Query: 361 EATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEV 420
EA EV+MKNSFKDVD FQK+L LD K++D CK+N EASSD CSALL+ IF PLEE V
Sbjct: 361 EAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAV 420
Query: 421 KAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQIL 480
K GIYSKPGG+ LFIQK ++L+ KYY EPRKGIQAEE+LQ YLKSKESV+ AILQTDQ L
Sbjct: 421 KQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQAL 480
Query: 481 TEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQL 540
TE EK+ + VKAE+ +A A+ + +Q + +QMM+E+E+ +QE V+Q ME +
Sbjct: 481 TETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQ----MEIAKQNW 536
Query: 541 LEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTL 581
L EQ+K ++QEQA L Q ++ L +E+Q Q+T+
Sbjct: 537 LAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTV 577
>gi|148234215 guanylate binding protein 4-like [Homo sapiens]
Length = 638
Score = 647 bits (1668), Expect = 0.0
Identities = 325/583 (55%), Positives = 432/583 (74%), Gaps = 1/583 (0%)
Query: 1 MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
MA EIHM GP+CL ENT G LV N EAL+ILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
Sbjct: 1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG 60
Query: 61 KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV 120
KNKGF LG TVKS TKGIWMWCVPHP KP HTL+LLDTEGLGD++K D ++DSWIF LAV
Sbjct: 61 KNKGFPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAV 120
Query: 121 LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL 180
LLSS+ VYNSMGTIN QA++QL+YVTELT IR+KS P +E EDS++FVSFFPDF+WT+
Sbjct: 121 LLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTV 180
Query: 181 RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI 240
RDF+L+L+ DG P+T DEYLE +LKL G + + +N N PR IR FFPK+KCFVFD PI
Sbjct: 181 RDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPI 240
Query: 241 HRRK-LAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYI 299
+ +K L +E++++++LD F Q +FCSYIF+++KTKTL GI V G RL LV TY+
Sbjct: 241 NDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYL 300
Query: 300 NAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSE 359
+AI+ G PC+ENA+ LAQ ENSAAVQ+A HY QQM Q+V+ P +TLQELLD+H V E
Sbjct: 301 DAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCE 360
Query: 360 REATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEE 419
REA V+M+ SFKD FQKKL ++KK++DF QN+EAS+ C A L+ + L E
Sbjct: 361 REAIAVFMEYSFKDKSQEFQKKLVDTMEKKKEDFVLQNEEASAKYCQAELKRLSELLTES 420
Query: 420 VKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQI 479
+ G + PGG+ ++++ + +E+ Y PRKG++A+E+LQ++L+S+ + ++ILQ+D+
Sbjct: 421 ISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKADEVLQSFLQSQVVIEESILQSDKA 480
Query: 480 LTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQ 539
LT EK I + K E+A+ +++ + Q + QQMME +E+S+QE++ QL +KMERER
Sbjct: 481 LTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMEREREN 540
Query: 540 LLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLK 582
+ E K L+ K++ +L E + L EI +L++ ++
Sbjct: 541 YMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIE 583
>gi|31377634 guanylate binding protein 4 [Homo sapiens]
Length = 640
Score = 633 bits (1632), Expect = 0.0
Identities = 320/590 (54%), Positives = 432/590 (73%), Gaps = 2/590 (0%)
Query: 7 MTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFS 66
M P+CL+EN +L N +AL+IL I+QPVVVVAIVGLYRTGKSYLMN+LAGK GF
Sbjct: 22 MMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFP 81
Query: 67 LGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTL 126
LGSTV+S TKGIWMWCVPH KP HTLVLLDTEGLGDV+K + +NDSWIF LAVLLSS+
Sbjct: 82 LGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSF 141
Query: 127 VYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLD 186
VYNS+ TIN QA++QL+YVTEL IR+KS P +E EDS++F SFFPDF+WT+RDF+L+
Sbjct: 142 VYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLE 201
Query: 187 LEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIH-RRKL 245
L+ DG P+T DEYLE +LKL G + K +N N+PR CIR FF K+KCFVFD P + ++ L
Sbjct: 202 LKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYL 261
Query: 246 AQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRG 305
++++ +E L+ F+ Q +FCSYIF+++KTKTL GI V G RL +LV+TY++AI+ G
Sbjct: 262 NHMDEVPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSG 321
Query: 306 DLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEV 365
+PC+ENAV ALAQ+EN AAVQ+A HY QQM Q+++LP +TLQELLD+H EREA V
Sbjct: 322 AVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAV 381
Query: 366 YMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIY 425
+M++SFKD +H FQKKL ++KK+ DF QN+EAS+ C A L+ + L E + GI+
Sbjct: 382 FMEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIF 441
Query: 426 SKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEK 485
S PGG+ L++++ + +E Y PRKG++A E+LQ +L+S+ V ++ILQ+D+ LT EK
Sbjct: 442 SVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEK 501
Query: 486 EIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQE 545
I E E+A+ +++ E Q + QQMME +E+S+QE++ Q+ +K+E ER LL E E
Sbjct: 502 AIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEYMAQMEKKLEEERENLLREHE 561
Query: 546 KTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 595
+ L KL+ Q +LKE Q +S QL EI +L++ + + TK LKI
Sbjct: 562 RLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKI-ESTKNEQLRLLKI 610
>gi|157671915 guanylate binding protein family, member 6 [Homo
sapiens]
Length = 633
Score = 615 bits (1585), Expect = e-176
Identities = 303/576 (52%), Positives = 421/576 (73%), Gaps = 1/576 (0%)
Query: 7 MTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFS 66
M P+CL+EN N +L+ N +A++IL I+QPVVVVAIVGLYRTGKSYLMN LAG+N GF
Sbjct: 7 MLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQNHGFP 66
Query: 67 LGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTL 126
LGSTV+S TKGIWMWCVPHP KP HTLVLLDTEGLGDV+KGD +NDSWIF LAVLL ST
Sbjct: 67 LGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTF 126
Query: 127 VYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLD 186
VYNSM TIN QA++QL+YVTELT I++KSSP + EDS +FVSFFPDF+WT+RDF+L+
Sbjct: 127 VYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLE 186
Query: 187 LEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRK-L 245
L+ +G P+T DEYLE +LKL QG + + + N PR CIR+FFPK+KCFVFD P + + L
Sbjct: 187 LKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLL 246
Query: 246 AQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRG 305
A +EK+ +++LDP+F +Q FCSYIF++++TKTL GI V G RL +L +TY+ AI+ G
Sbjct: 247 ANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSG 306
Query: 306 DLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEV 365
+PC+ENAV+ LAQ ENSAAVQ+A +Y QQM Q+V+LP +TLQELLD+H EREA +
Sbjct: 307 AVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACEREAIAI 366
Query: 366 YMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIY 425
+M++SFKD + FQKK K+ DF QN+E+S C A L + L E + AG +
Sbjct: 367 FMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSF 426
Query: 426 SKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEK 485
S PGG+ L+++ + +E+ Y++ PRKG++A+E+ Q +L+S+ + ++ILQ+D+ LT++EK
Sbjct: 427 SVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKALTDREK 486
Query: 486 EIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQE 545
+ V+ K E+A+ +++++ + QQ ME ++KS +E++ QL EK++ ER LL EQ
Sbjct: 487 AVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREHLLREQI 546
Query: 546 KTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTL 581
L + Q L E + + ++ EI + ++ +
Sbjct: 547 MMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMI 582
>gi|45827806 atlastin 3 [Homo sapiens]
Length = 541
Score = 71.2 bits (173), Expect = 2e-12
Identities = 92/389 (23%), Positives = 158/389 (40%), Gaps = 45/389 (11%)
Query: 38 VVVVAIVGLYRTGKSYLMN---------KLAGKNK----------GFSLGSTVKSHTKGI 78
VVVV++ G +R GKS++++ K +G + GFS T GI
Sbjct: 60 VVVVSVAGAFRKGKSFILDFMLRYLYSQKESGHSNWLGDPEEPLTGFSWRGGSDPETTGI 119
Query: 79 WMW----CVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTI 134
+W V P + +VL+DT+G D + ++ + IF L+ + SS +YN I
Sbjct: 120 QIWSEVFTVEKPGGKKVAVVLMDTQGAFD-SQSTVKDCATIFALSTMTSSVQIYNLSQNI 178
Query: 135 NQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPL 194
+ + QL TE + + DE F F ++ +RD+S E
Sbjct: 179 QEDDLQQLQLFTEY-----GRLAMDE-------IFQKPFQTLMFLVRDWSFPYEYSYGLQ 226
Query: 195 TPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDE 254
+L+ L++ + ++ +N R I F CF+ P + + + +
Sbjct: 227 GGMAFLDKRLQVKEHQHEEIQNV---RNHIHSCFSDVTCFLLPHPGLQVATSPDFDGKLK 283
Query: 255 ELDPEFVQQVADFCSYIFSNSKTKTLS-GGIKVNGPRLESLVLTYINAISRGDLPCMENA 313
++ EF +Q+ Y+ + SK G KV L YI DLP ++
Sbjct: 284 DIAGEFKEQLQALIPYVLNPSKLMEKEINGSKVTCRGLLEYFKAYIKIYQGEDLPHPKSM 343
Query: 314 VLALAQIENSAAVQKAIAHYDQQM-----GQKVQLPAETLQELLDLHRVSEREATEVYMK 368
+ A A+ N AA A Y M G+K L + L+E + + + K
Sbjct: 344 LQATAEANNLAAAASAKDIYYNNMEEVCGGEKPYLSPDILEEKHCEFKQLALDHFKKTKK 403
Query: 369 NSFKDVDHLFQKKLAAQLDKKRDDFCKQN 397
KD +Q++L ++ + ++FCK N
Sbjct: 404 MGGKDFSFRYQQELEEEIKELYENFCKHN 432
>gi|169160863 PREDICTED: similar to guanylate-binding protein 5
[Homo sapiens]
Length = 112
Score = 70.1 bits (170), Expect = 5e-12
Identities = 36/74 (48%), Positives = 50/74 (67%), Gaps = 1/74 (1%)
Query: 315 LALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDV 374
+ LAQ ENS A+Q+A HY QQM Q+++ P + LQELLD+H EREA V+M++S +
Sbjct: 1 MTLAQRENSVALQRAANHYSQQMAQRMRFPTDMLQELLDMHTACEREAIAVFMEHS-RGE 59
Query: 375 DHLFQKKLAAQLDK 388
+ FQKKL + K
Sbjct: 60 NQEFQKKLMSHWGK 73
>gi|208610002 atlastin GTPase 2 isoform 2 [Homo sapiens]
Length = 583
Score = 70.1 bits (170), Expect = 5e-12
Identities = 92/390 (23%), Positives = 166/390 (42%), Gaps = 50/390 (12%)
Query: 38 VVVVAIVGLYRTGKSYLM--------NK-----LAGKNK---GFSLGSTVKSHTKGIWMW 81
+VVV++ G +R GKS+L+ NK + G N+ GF+ + T GI +W
Sbjct: 94 IVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVW 153
Query: 82 ----CVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQ 137
+ P + ++L+DT+G D + ++ + +F L+ + SS VYN I +
Sbjct: 154 NEVFVIDRPNGTKVAVLLMDTQGAFD-SQSTIKDCATVFALSTMTSSVQVYNLSQNIQED 212
Query: 138 AMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPD 197
+ L TE + + F ++ +RD+S E
Sbjct: 213 DLQHLQLFTEYGRLAMEEI------------YQKPFQTLMFLIRDWSYPYEHSYGLEGGK 260
Query: 198 EYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQD--EE 255
++LE L++ Q ++ +N R I F CF+ LP K+A ++
Sbjct: 261 QFLEKRLQVKQNQHEELQNV---RKHIHNCFSNLGCFL--LPHPGLKVATNPSFDGRLKD 315
Query: 256 LDPEFVQQVADFCSYIFS--NSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENA 313
+D +F +++ + + + N K +SG KV L YI +LP ++
Sbjct: 316 IDEDFKRELRNLVPLLLAPENLVEKEISGS-KVTCRDLVEYFKAYIKIYQGEELPHPKSM 374
Query: 314 VLALAQIENSAAVQKAIAHYDQQM-----GQKVQL-PAETLQELLDLHRVSEREATEVYM 367
+ A A+ N AAV A Y + M G K + P++ ++ LDL V+ ++ V
Sbjct: 375 LQATAEANNLAAVAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSV-K 433
Query: 368 KNSFKDVDHLFQKKLAAQLDKKRDDFCKQN 397
K + +Q +L A++++ +F K N
Sbjct: 434 KMGGDEFCRRYQDQLEAEIEETYANFIKHN 463
>gi|208610000 atlastin GTPase 2 isoform 1 [Homo sapiens]
Length = 579
Score = 70.1 bits (170), Expect = 5e-12
Identities = 92/390 (23%), Positives = 166/390 (42%), Gaps = 50/390 (12%)
Query: 38 VVVVAIVGLYRTGKSYLM--------NK-----LAGKNK---GFSLGSTVKSHTKGIWMW 81
+VVV++ G +R GKS+L+ NK + G N+ GF+ + T GI +W
Sbjct: 94 IVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVW 153
Query: 82 ----CVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQ 137
+ P + ++L+DT+G D + ++ + +F L+ + SS VYN I +
Sbjct: 154 NEVFVIDRPNGTKVAVLLMDTQGAFD-SQSTIKDCATVFALSTMTSSVQVYNLSQNIQED 212
Query: 138 AMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPD 197
+ L TE + + F ++ +RD+S E
Sbjct: 213 DLQHLQLFTEYGRLAMEEI------------YQKPFQTLMFLIRDWSYPYEHSYGLEGGK 260
Query: 198 EYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQD--EE 255
++LE L++ Q ++ +N R I F CF+ LP K+A ++
Sbjct: 261 QFLEKRLQVKQNQHEELQNV---RKHIHNCFSNLGCFL--LPHPGLKVATNPSFDGRLKD 315
Query: 256 LDPEFVQQVADFCSYIFS--NSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENA 313
+D +F +++ + + + N K +SG KV L YI +LP ++
Sbjct: 316 IDEDFKRELRNLVPLLLAPENLVEKEISGS-KVTCRDLVEYFKAYIKIYQGEELPHPKSM 374
Query: 314 VLALAQIENSAAVQKAIAHYDQQM-----GQKVQL-PAETLQELLDLHRVSEREATEVYM 367
+ A A+ N AAV A Y + M G K + P++ ++ LDL V+ ++ V
Sbjct: 375 LQATAEANNLAAVAGARDTYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVAIKQFRSV-K 433
Query: 368 KNSFKDVDHLFQKKLAAQLDKKRDDFCKQN 397
K + +Q +L A++++ +F K N
Sbjct: 434 KMGGDEFCRRYQDQLEAEIEETYANFIKHN 463
>gi|189181742 atlastin GTPase 1 isoform b [Homo sapiens]
Length = 553
Score = 68.9 bits (167), Expect = 1e-11
Identities = 88/386 (22%), Positives = 162/386 (41%), Gaps = 68/386 (17%)
Query: 38 VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFSLGSTVKSHTKGIWMW 81
VV V++ G +R GKS+LM+ + N+ GFS + T GI +W
Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126
Query: 82 ----CVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQ 137
+ P + ++L+DT+G D + ++ + +F L+ ++SS VYN + +
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFD-SQSTLRDSATVFALSTMISSIQVYNLSQNVQED 185
Query: 138 AMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLE----ADGQP 193
+ L TE ++ F+ F ++ +RD+S E ADG
Sbjct: 186 DLQHLQLFTEYGRLAMEET------------FLKPFQSLIFLVRDWSFPYEFSYGADGGA 233
Query: 194 LTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQD 253
++LE LK++ ++ +N R I F CF+ LP K+A
Sbjct: 234 ----KFLEKRLKVSGNQHEELQNV---RKHIHSCFTNISCFL--LPHPGLKVATNPNFDG 284
Query: 254 --EELDPEFVQQVADFCSYIFS--NSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPC 309
+E+D EF++ + ++ S + K ++G K+ L YI +LP
Sbjct: 285 KLKEIDDEFIKNLKILIPWLLSPESLDIKEINGN-KITCRGLVEYFKAYIKIYQGEELPH 343
Query: 310 MENAVLALAQIENSAAVQKAIAHYDQQM-----GQK------------VQLPAETLQELL 352
++ + A A+ N AAV A Y+++M G K +QL E+++
Sbjct: 344 PKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFR 403
Query: 353 DLHRVSEREATEVYMKNSFKDVDHLF 378
+ ++ E + Y++ ++D L+
Sbjct: 404 GVKKMGGEEFSRRYLQQLESEIDELY 429
>gi|74024917 atlastin GTPase 1 isoform b [Homo sapiens]
Length = 553
Score = 68.9 bits (167), Expect = 1e-11
Identities = 88/386 (22%), Positives = 162/386 (41%), Gaps = 68/386 (17%)
Query: 38 VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFSLGSTVKSHTKGIWMW 81
VV V++ G +R GKS+LM+ + N+ GFS + T GI +W
Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126
Query: 82 ----CVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQ 137
+ P + ++L+DT+G D + ++ + +F L+ ++SS VYN + +
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFD-SQSTLRDSATVFALSTMISSIQVYNLSQNVQED 185
Query: 138 AMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLE----ADGQP 193
+ L TE ++ F+ F ++ +RD+S E ADG
Sbjct: 186 DLQHLQLFTEYGRLAMEET------------FLKPFQSLIFLVRDWSFPYEFSYGADGGA 233
Query: 194 LTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQD 253
++LE LK++ ++ +N R I F CF+ LP K+A
Sbjct: 234 ----KFLEKRLKVSGNQHEELQNV---RKHIHSCFTNISCFL--LPHPGLKVATNPNFDG 284
Query: 254 --EELDPEFVQQVADFCSYIFS--NSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPC 309
+E+D EF++ + ++ S + K ++G K+ L YI +LP
Sbjct: 285 KLKEIDDEFIKNLKILIPWLLSPESLDIKEINGN-KITCRGLVEYFKAYIKIYQGEELPH 343
Query: 310 MENAVLALAQIENSAAVQKAIAHYDQQM-----GQK------------VQLPAETLQELL 352
++ + A A+ N AAV A Y+++M G K +QL E+++
Sbjct: 344 PKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFR 403
Query: 353 DLHRVSEREATEVYMKNSFKDVDHLF 378
+ ++ E + Y++ ++D L+
Sbjct: 404 GVKKMGGEEFSRRYLQQLESEIDELY 429
>gi|19923445 atlastin GTPase 1 isoform a [Homo sapiens]
Length = 558
Score = 68.9 bits (167), Expect = 1e-11
Identities = 88/386 (22%), Positives = 162/386 (41%), Gaps = 68/386 (17%)
Query: 38 VVVVAIVGLYRTGKSYLMNKL-------------AGKNK---GFSLGSTVKSHTKGIWMW 81
VV V++ G +R GKS+LM+ + N+ GFS + T GI +W
Sbjct: 67 VVAVSVAGAFRKGKSFLMDFMLRYMYNQESVDWVGDYNEPLTGFSWRGGSERETTGIQIW 126
Query: 82 ----CVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQ 137
+ P + ++L+DT+G D + ++ + +F L+ ++SS VYN + +
Sbjct: 127 SEIFLINKPDGKKVAVLLMDTQGTFD-SQSTLRDSATVFALSTMISSIQVYNLSQNVQED 185
Query: 138 AMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLE----ADGQP 193
+ L TE ++ F+ F ++ +RD+S E ADG
Sbjct: 186 DLQHLQLFTEYGRLAMEET------------FLKPFQSLIFLVRDWSFPYEFSYGADGGA 233
Query: 194 LTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQD 253
++LE LK++ ++ +N R I F CF+ LP K+A
Sbjct: 234 ----KFLEKRLKVSGNQHEELQNV---RKHIHSCFTNISCFL--LPHPGLKVATNPNFDG 284
Query: 254 --EELDPEFVQQVADFCSYIFS--NSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPC 309
+E+D EF++ + ++ S + K ++G K+ L YI +LP
Sbjct: 285 KLKEIDDEFIKNLKILIPWLLSPESLDIKEINGN-KITCRGLVEYFKAYIKIYQGEELPH 343
Query: 310 MENAVLALAQIENSAAVQKAIAHYDQQM-----GQK------------VQLPAETLQELL 352
++ + A A+ N AAV A Y+++M G K +QL E+++
Sbjct: 344 PKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFR 403
Query: 353 DLHRVSEREATEVYMKNSFKDVDHLF 378
+ ++ E + Y++ ++D L+
Sbjct: 404 GVKKMGGEEFSRRYLQQLESEIDELY 429
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 60.1 bits (144), Expect = 6e-09
Identities = 55/269 (20%), Positives = 126/269 (46%), Gaps = 19/269 (7%)
Query: 321 ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREAT--EVYMKNSFKDVDHLF 378
E ++Q+ ++ Q++ ++ +E +++ L ++ E+E E + + + F
Sbjct: 450 EERISLQQELSRVKQEVVDVMKKSSE--EQIAKLQKLHEKELARKEQELTKKLQTREREF 507
Query: 379 QKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKL 438
Q+++ L+K + ++ K +QE AL + LE + KA + KL
Sbjct: 508 QEQMKVALEKSQSEYLKISQEKEQQESLALEE-----LELQKKAILTESEN-------KL 555
Query: 439 QDLEKKYYEEPRKGIQAEEILQTYLK-SKESVTDAILQTDQILTEKEKEIEVECVKAESA 497
+DL+++ + ++ E L+ L+ +K D + + + KEI V K ++
Sbjct: 556 RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE 615
Query: 498 QASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQAR 557
S K + + + ++ ++ YQ +++L EK E+E+ LL+++E + ++E
Sbjct: 616 LESLK--HQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNE 673
Query: 558 VLKERCQGESTQLQNEIQKLQKTLKKKTK 586
E+ + T+L++ +L + LK + K
Sbjct: 674 KTLEKLDVKQTELESLSSELSEVLKARHK 702
Score = 51.2 bits (121), Expect = 3e-06
Identities = 64/293 (21%), Positives = 134/293 (45%), Gaps = 34/293 (11%)
Query: 321 ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSE---REATEVYMKNSFKDVDHL 377
E + V+K + Q+ L E LQ L ++ RE E + KD + +
Sbjct: 604 EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII 663
Query: 378 FQKKLAAQLDKKRD--DFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFI 435
FQ + +K + D + E+ S S +L+ LEEE+ + + +
Sbjct: 664 FQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHK-LEEELSV-LKDQTDKMKQEL 721
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEK---------- 485
+ D +K ++++ I E + ++++++ D I Q + +L E++K
Sbjct: 722 EAKMDEQKNHHQQQVDSIIKEHEVSIQ-RTEKALKDQINQLELLLKERDKHLKEHQAHVE 780
Query: 486 --EIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEK---MERERAQL 540
E +++ + E QASAK+ ++ YQ E+ K+Y+E + QL +K +E ER L
Sbjct: 781 NLEADIKRSEGELQQASAKL--DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILL 838
Query: 541 ------LEEQEKTLTSKLQE---QARVLKERCQGESTQLQNEIQKLQKTLKKK 584
+E Q+K + ++L Q + L ++ + ++++++ +++ L + + K
Sbjct: 839 TKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK 891
Score = 50.1 bits (118), Expect = 6e-06
Identities = 71/319 (22%), Positives = 142/319 (44%), Gaps = 50/319 (15%)
Query: 311 ENAVLALAQIENSAA-VQKAIAHYD---QQMGQKVQLPAETLQELLDLHRVSEREATEVY 366
+N + A +EN VQK + + Q + QK++ L ++HRV E T Y
Sbjct: 1822 KNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKY 1881
Query: 367 MK--------------------NSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCS 406
K K HL Q KL + ++ + +D + + A ++R
Sbjct: 1882 EKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDL--EFKLAGAEREK 1939
Query: 407 ALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSK 466
L L+++++ Q+L+ L+K+Y +E + I+ E+ LK
Sbjct: 1940 QKLGKEIVRLQKDLRMLRKEHQ-------QELEILKKEYDQEREEKIKQEQE-DLELKHN 1991
Query: 467 ESVTDAILQTDQILTEKEKEIEVECVKA--ESAQASAKMVEEMQIKYQQMMEEKEKSYQE 524
++ + + + L +KE+E+E+ + ++ + A+++E Q + Q++ +K +
Sbjct: 1992 STLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLL-KKIAEKDD 2050
Query: 525 HVKQLTEKMERERAQLLEEQEKTLTSK---LQEQARVLKERCQGESTQLQN------EIQ 575
+K+ ++ E ++L+ +E+ +T+K LQ Q L+++ Q + Q +N I
Sbjct: 2051 DLKRTAKRYE----EILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIM 2106
Query: 576 KLQKTLKKKTKRYMSHKLK 594
+LQ L +KT KLK
Sbjct: 2107 ELQTQLAQKTTLISDSKLK 2125
Score = 48.9 bits (115), Expect = 1e-05
Identities = 58/287 (20%), Positives = 133/287 (46%), Gaps = 23/287 (8%)
Query: 310 MENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKN 369
+E + +I Q+++A + ++ QK + E+ +L DL + +E T +
Sbjct: 515 LEKSQSEYLKISQEKEQQESLALEELEL-QKKAILTESENKLRDLQQEAETYRTRIL--- 570
Query: 370 SFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPG 429
+++ +K L ++ +D + EA ++ + + V+ + E+++ + +
Sbjct: 571 ---ELESSLEKSLQENKNQSKD--LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA 625
Query: 430 GYCLFIQKLQDLEKKYYEEPRK-GIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIE 488
L+ +KLQ L+++Y E K + E+ +T LK KE + A ++ EK +E
Sbjct: 626 ---LWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE-----MNEKTLE 677
Query: 489 VECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTL 548
VK ++ + + E+ +K + +EE+ +K T+KM++E ++EQ+
Sbjct: 678 KLDVKQTELESLSSELSEV-LKARHKLEEELSV----LKDQTDKMKQELEAKMDEQKNHH 732
Query: 549 TSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 595
++ + + Q L+++I +L+ LK++ K H+ +
Sbjct: 733 QQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHV 779
Score = 46.6 bits (109), Expect = 6e-05
Identities = 43/188 (22%), Positives = 83/188 (44%), Gaps = 22/188 (11%)
Query: 382 LAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDL 441
L + D++R++ KQ QE + ++ L+ + ++ QK Q+L
Sbjct: 1967 LKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLA--------------QKEQEL 2012
Query: 442 EKKYYEEPRKGIQAE-EILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQAS 500
E E K + E E+L+++ + + I + D L K E E + A + +
Sbjct: 2013 EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYE-EILDAREEEMT 2071
Query: 501 AKM------VEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQE 554
AK+ +EE+Q KYQQ +E++E ++V + + + + L K + +E
Sbjct: 2072 AKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE 2131
Query: 555 QARVLKER 562
Q L++R
Sbjct: 2132 QIHNLEDR 2139
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/165 (26%), Positives = 78/165 (47%), Gaps = 21/165 (12%)
Query: 438 LQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKE-----------KE 486
+Q LEK+ E +K + + Q Y E QT QIL EKE KE
Sbjct: 867 MQQLEKQNSEMEQK---VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKE 923
Query: 487 IEVECVKAESAQASAKMV-EEMQIKY---QQMMEEKEKSYQEHVKQLTEKMERERAQLLE 542
IE+ K + + S ++ EE + K+ ++ ME+ ++ +E + L +K+ + A+L +
Sbjct: 924 IEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983
Query: 543 EQEKT---LTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKK 584
E E T L+ K ++ + E Q S + + + +L+ K++
Sbjct: 984 ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQ 1028
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/142 (21%), Positives = 72/142 (50%), Gaps = 4/142 (2%)
Query: 453 IQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQ 512
++ EEI Q + K+ T Q +++ +KEK + E A ++A+ EE + K +
Sbjct: 379 MKEEEIAQLRSRIKQMTT----QGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLK 434
Query: 513 QMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQN 572
M+E+ K+ ++ ++ +++E +++ +E + +EQ L++ + E + +
Sbjct: 435 AEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494
Query: 573 EIQKLQKTLKKKTKRYMSHKLK 594
E+ K +T +++ + M L+
Sbjct: 495 ELTKKLQTREREFQEQMKVALE 516
Score = 38.5 bits (88), Expect = 0.018
Identities = 61/279 (21%), Positives = 116/279 (41%), Gaps = 48/279 (17%)
Query: 327 QKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQL 386
+K + D + + L +E + L H++ E + KD +++L A++
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSV-------LKDQTDKMKQELEAKM 725
Query: 387 DKKRDDFCKQ------NQEASSDRCSALLQVIFSPLE-----------------EEVKAG 423
D++++ +Q E S R L+ + LE E ++A
Sbjct: 726 DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785
Query: 424 IYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQA--EEILQTYLKSKESVTDAILQTDQILT 481
I G KL D+ + Y + +A E++ Q K + T+ IL T Q+
Sbjct: 786 IKRSEGELQQASAKL-DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVA- 843
Query: 482 EKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQE---HVKQLTEKMERERA 538
EVE K + ++ +I+ Q +M++ EK E VK LT+ E +
Sbjct: 844 ------EVEAQKKDVCTE----LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE 893
Query: 539 QLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKL 577
+EQE+T ++++ +L+ R +G+ +++ QKL
Sbjct: 894 DGNKEQEQTKQILVEKENMILQMR-EGQKKEIEILTQKL 931
Score = 38.1 bits (87), Expect = 0.023
Identities = 63/278 (22%), Positives = 125/278 (44%), Gaps = 47/278 (16%)
Query: 342 QLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKL---------AAQLDKKRDD 392
+L A +Q + DL + E++ +E M+ K + +++ KL Q+ ++++
Sbjct: 855 ELDAHKIQ-VQDLMQQLEKQNSE--MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKEN 911
Query: 393 FCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKG 452
Q +E L Q + + +E I ++ + K ++ EKK + +K
Sbjct: 912 MILQMREGQKKEIEILTQKLSA---KEDSIHILNEE-----YETKFKNQEKKMEKVKQKA 963
Query: 453 IQAEEILQTYLKSKESVTDAILQTDQI-LTEKEKEIEVECVKAESAQASAKMVEEMQIKY 511
+ +E L+ L +E+ L+ + L++KEK+ + + E AQA++ + + +
Sbjct: 964 KEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKML--EMAQANSAGISDAVSRL 1021
Query: 512 QQMMEEKEKSYQE-HVKQLT------EKMERERAQLLEE-QEKTLTSKLQEQARVL---- 559
+ +E+ +S E H ++L EK ++A+ L+E E L K QE A +
Sbjct: 1022 ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKIL 1081
Query: 560 -----KERCQGESTQLQNE-------IQKLQKTLKKKT 585
KE E T L+ E + +LQ+ LK+K+
Sbjct: 1082 LFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS 1119
Score = 37.7 bits (86), Expect = 0.030
Identities = 59/264 (22%), Positives = 112/264 (42%), Gaps = 45/264 (17%)
Query: 319 QIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLF 378
Q++NS ++ + A Q + E L ++ DL SFK VD L
Sbjct: 1382 QLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDL---------------SFK-VDTLS 1425
Query: 379 QKKLAA--QLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAG-IYSKPGGYCLFI 435
++K++A Q+D + F + ++A S V ++ E+K+ Y K L
Sbjct: 1426 KEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLK 1485
Query: 436 QKLQDLEKKY-------YEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIE 488
++L K++ ++ K + E L+T LKS+ T I++ + +T+K EIE
Sbjct: 1486 EELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQ---TARIMELEDHITQKTIEIE 1542
Query: 489 VECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTL 548
+ E+ Y Q + + K + ++ E E + ++ E +EK L
Sbjct: 1543 --------------SLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKIL 1588
Query: 549 TSKLQEQARVLKERCQGESTQLQN 572
T L+ Q +K + + +L++
Sbjct: 1589 T--LENQVYSMKAELETKKKELEH 1610
Score = 37.4 bits (85), Expect = 0.039
Identities = 67/298 (22%), Positives = 119/298 (39%), Gaps = 41/298 (13%)
Query: 320 IENSAAVQKAIAHYDQQMGQKVQLPAETLQE---LLDLHRVSEREATEVYMKNSFKDVDH 376
+EN KA ++ + V L ++ +E L+ SE A +K +
Sbjct: 1590 LENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIA 1649
Query: 377 LFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSP--LEEEVKAGIYSKPGGYCLF 434
+K+L +Q+++K + + K + S+ + L + LEE++K+ S+ L
Sbjct: 1650 AIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQ--SETLI 1707
Query: 435 IQKLQDLEKKYYEEPRKGIQA------EE---ILQTYLKSKESVTDAILQTDQILTEKEK 485
+ + Y E+ Q EE +LQ L KE + + Q +
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767
Query: 486 EIEVE----CVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQ----EHVKQLTEKMERER 537
E+ + +K E A+A + M Q+ +EEK K Y +HV++ K +
Sbjct: 1768 EMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA 1827
Query: 538 AQLLEE---------QEKTLTSKLQEQARVLKERC--------QGESTQLQNEIQKLQ 578
Q LE QEK LT ++ EQ + C + E +L ++ +KLQ
Sbjct: 1828 KQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQ 1885
Score = 35.0 bits (79), Expect = 0.20
Identities = 57/263 (21%), Positives = 103/263 (39%), Gaps = 23/263 (8%)
Query: 349 QELLDLHRVSEREATEVY-MKNSFKDVDHLFQ------KKLAAQLDKKRDDFCKQNQEAS 401
++L++L ++E + +V + + K D FQ +K L+ K +F K ++E +
Sbjct: 1155 EQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA 1214
Query: 402 S--DRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYE----EPRKGIQA 455
D C + + E+ SK I Q K E + +
Sbjct: 1215 IQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSEL 1274
Query: 456 EEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMM 515
E L+ + + ++ + Q L EKE +I+ ES + +++ QQ
Sbjct: 1275 EAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAA 1334
Query: 516 EEKEKSYQEHVKQLTEKMERERAQLLEEQEKTL-TSKLQEQARVLKERCQGESTQLQNEI 574
EKE + K+L+E + E +EK + S L +Q L + QLQN I
Sbjct: 1335 SEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL-------NVQLQNSI 1387
Query: 575 QKLQK--TLKKKTKRYMSHKLKI 595
+K + K+Y K ++
Sbjct: 1388 SLSEKEAAISSLRKQYDEEKCEL 1410
Score = 32.3 bits (72), Expect = 1.3
Identities = 32/154 (20%), Positives = 72/154 (46%), Gaps = 16/154 (10%)
Query: 447 EEPRKGIQAEEILQTYLKSKE--------SVTDAILQTDQILTEKEKEIEVECVKAESAQ 498
+E + I A +++ LK K+ +TD +Q ++ EKE + ++ + +
Sbjct: 1346 KELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDE 1405
Query: 499 ASAKMVEEMQ-IKYQQMMEEKEK-SYQEHVKQLTEKME--RERAQLLEEQEKTLTSKLQE 554
++++++Q + ++ KEK S E V + K +++AQ Q + +LQ
Sbjct: 1406 EKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465
Query: 555 QARVLKERCQGESTQLQNEIQKLQKTLKKKTKRY 588
Q + + E+ + +I L++ L ++ KR+
Sbjct: 1466 QLELKSK----EAYEKDEQINLLKEELDQQNKRF 1495
Score = 31.2 bits (69), Expect = 2.8
Identities = 54/290 (18%), Positives = 130/290 (44%), Gaps = 51/290 (17%)
Query: 350 ELLDLHRVSEREATE---VYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEAS---SD 403
EL+ +++ +RE + + ++ K + + + + Q+D++ ++ +AS D
Sbjct: 159 ELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKD 218
Query: 404 RCSALLQVIFSPLEEEVKAGIYS----KPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEIL 459
+ ++LQ S L++ ++ G + KP + +L+ + + +E E ++
Sbjct: 219 QYISVLQTQVSLLKQRLRNGPMNVDVLKP------LPQLEPQAEVFTKEENPESDGEPVV 272
Query: 460 Q--TYLKSKESVTDAILQTDQILTEKEKEIEV---ECV------KAESAQASAKMVEEMQ 508
+ T +K+ E++ + + + +L ++ I+ +C +A Q ++ E +
Sbjct: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEK 332
Query: 509 IKYQQMMEEKEKSYQ-EHVKQLTEKMERERAQLL--------------EEQEKTLTSKLQ 553
IK M E+ + Q K L E++E+++ ++ EE+ L S+++
Sbjct: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIK 392
Query: 554 ------EQARVLKERCQGES-TQLQNEIQKLQKT--LKKKTKRYMSHKLK 594
E+ R KE+ + + +L+ + QKT ++K K M ++K
Sbjct: 393 QMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIK 442
>gi|91208418 transcription elongation regulator 1 isoform 2 [Homo
sapiens]
Length = 1077
Score = 55.5 bits (132), Expect = 1e-07
Identities = 68/298 (22%), Positives = 126/298 (42%), Gaps = 40/298 (13%)
Query: 321 ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER-EATEVYMKNSFKDVDHLFQ 379
E + +A + + M + P T E H R +A E KD + LF
Sbjct: 699 EKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIE-----KMKDREALFN 753
Query: 380 KKLAAQLDKKRDDFCKQNQEASSDRCSALL------QVIFSPLEEEVKA-----GIYSKP 428
+ +AA K+++D + ++ SD L Q +S ++++V++ + S
Sbjct: 754 EFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSS 813
Query: 429 GGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAIL--QTDQILTEKEKE 486
LF Q ++ + K E K ++ + ++ L+ +E QT +I E+E+
Sbjct: 814 MREDLFKQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQH 873
Query: 487 IEVECVKAESAQASAKMVEEMQIKYQQMM-----------------EEKEKSYQEHVKQL 529
E ++ A S MV + + EEKEK + EH++ L
Sbjct: 874 KREEAIQNFKALLS-DMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEAL 932
Query: 530 TEKMERERAQLLEEQEK-TLTSKLQEQARVLKE--RCQGESTQLQNEIQKLQKTLKKK 584
T+K QLL+E TLTS +E +++KE RC S+ + + ++ ++ ++ K
Sbjct: 933 TKKKREHFRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDK 990
>gi|21327715 transcription elongation regulator 1 isoform 1 [Homo
sapiens]
Length = 1098
Score = 55.5 bits (132), Expect = 1e-07
Identities = 68/298 (22%), Positives = 126/298 (42%), Gaps = 40/298 (13%)
Query: 321 ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER-EATEVYMKNSFKDVDHLFQ 379
E + +A + + M + P T E H R +A E KD + LF
Sbjct: 720 EKKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIE-----KMKDREALFN 774
Query: 380 KKLAAQLDKKRDDFCKQNQEASSDRCSALL------QVIFSPLEEEVKA-----GIYSKP 428
+ +AA K+++D + ++ SD L Q +S ++++V++ + S
Sbjct: 775 EFVAAARKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSS 834
Query: 429 GGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAIL--QTDQILTEKEKE 486
LF Q ++ + K E K ++ + ++ L+ +E QT +I E+E+
Sbjct: 835 MREDLFKQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQH 894
Query: 487 IEVECVKAESAQASAKMVEEMQIKYQQMM-----------------EEKEKSYQEHVKQL 529
E ++ A S MV + + EEKEK + EH++ L
Sbjct: 895 KREEAIQNFKALLS-DMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEAL 953
Query: 530 TEKMERERAQLLEEQEK-TLTSKLQEQARVLKE--RCQGESTQLQNEIQKLQKTLKKK 584
T+K QLL+E TLTS +E +++KE RC S+ + + ++ ++ ++ K
Sbjct: 954 TKKKREHFRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDK 1011
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 53.1 bits (126), Expect = 7e-07
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 26/174 (14%)
Query: 440 DLEKKYYEEPRKGIQAEEIL---QTYLKSKES------------------VTDAILQTDQ 478
DL+K EE K +++L QT ++ +S V +LQ
Sbjct: 2580 DLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRS 2639
Query: 479 ILTEKEKEIEVECVKAESAQASAK----MVEEMQIKYQQMMEEKEKSYQEHVKQL-TEKM 533
+L+ KE E++ + ES Q + +EE Q+++ Q + K+ +E L T++
Sbjct: 2640 MLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRA 2699
Query: 534 ERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKR 587
+ R + + E+T LQ++ R+ RC+ Q ++++ +LQK L + R
Sbjct: 2700 QSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSR 2753
Score = 48.9 bits (115), Expect = 1e-05
Identities = 54/250 (21%), Positives = 111/250 (44%), Gaps = 30/250 (12%)
Query: 311 ENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNS 370
E VL Q +A +++ + ++ Q V+ E + DL + R+ ++
Sbjct: 315 EEVVLRCGQ--EAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSE 372
Query: 371 FKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGG 430
+D+ + FQK+LA Q + F +NQ ++R L+ E+++ + S+ G
Sbjct: 373 MEDLQNQFQKELAEQRAELEKIFQDKNQ---AERALRNLESHHQAAIEKLREDLQSEHG- 428
Query: 431 YCLFIQKLQDLEKKYYE-EPRKGIQAEEILQTY----LKSKESVTDAILQTD-------- 477
+ L+DLE K+ E E K ++ E + +Y +S+E + Q D
Sbjct: 429 -----RCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQE 483
Query: 478 ------QILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTE 531
Q+L + ++E +K +E+++I +++ + + EK+YQE + L +
Sbjct: 484 LSELHEQLLARTSRVEDLEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQ 543
Query: 532 KMERERAQLL 541
+++ R L
Sbjct: 544 RLQGAREDAL 553
Score = 37.0 bits (84), Expect = 0.051
Identities = 52/244 (21%), Positives = 111/244 (45%), Gaps = 41/244 (16%)
Query: 379 QKKLAAQLDKKRD---DFCKQNQEA---SSDRCSALLQVI-----FSPLEEEVKAGIY-- 425
QK LAA+ RD D C+ Q++ S C +V+ S E E+KA +
Sbjct: 2596 QKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQEL 2655
Query: 426 -SKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAI---LQTDQILT 481
S+ G +L++ + ++ + + +A E L+ L+++ + + + L+ +Q
Sbjct: 2656 ESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRASLETQRAQSSRLCVALKHEQTAK 2715
Query: 482 EK-EKEIEVECVKAESAQASAK-MVEEMQIKYQQMMEEKEKSYQ-----EHVKQLTEKME 534
+ +KE+ +E + E+ A + + E+Q + + EK ++ + H + LTE++
Sbjct: 2716 DNLQKELRIEHSRCEALLAQERSQLSELQ---KDLAAEKSRTLELSEALRHERLLTEQLS 2772
Query: 535 RERAQ------------LLEE--QEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKT 580
+ + LL++ +EK+ LQ ++++ QL+ E QK +
Sbjct: 2773 QRTQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEA 2832
Query: 581 LKKK 584
L+++
Sbjct: 2833 LRRE 2836
Score = 33.5 bits (75), Expect = 0.57
Identities = 48/215 (22%), Positives = 94/215 (43%), Gaps = 32/215 (14%)
Query: 405 CSALLQVIFSPLEE--EVKAGIYSKPGGYCLFIQKLQ----DLEKKYYEEPRKGIQAEEI 458
C ++ + LE E +AG++ + L ++ L+ ++ E + +Q E+
Sbjct: 215 CEQECELAITDLESGREDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQKEKE 274
Query: 459 -----LQTYLKSKESVTDAILQTDQ-----ILTE---KEKEIEVECVKAESAQASAKMVE 505
L+ L S+ + A+LQ+ Q +L E +EKE V E+A+ K+
Sbjct: 275 TALTELREMLNSRRAQELALLQSRQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQS 334
Query: 506 EMQIKYQQMM-------EEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARV 558
EM+ Q + EK+ + K+L+ K + E L + +K L + E ++
Sbjct: 335 EMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAEQRAELEKI 394
Query: 559 LKERCQGE------STQLQNEIQKLQKTLKKKTKR 587
+++ Q E + Q I+KL++ L+ + R
Sbjct: 395 FQDKNQAERALRNLESHHQAAIEKLREDLQSEHGR 429
Score = 33.5 bits (75), Expect = 0.57
Identities = 46/212 (21%), Positives = 93/212 (43%), Gaps = 30/212 (14%)
Query: 385 QLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKK 444
QL+ C Q++ SDRC + E G +S+ + + +Q +QD + +
Sbjct: 604 QLEALESPLCIQHEGHVSDRCCVETSALGHEWRLEPSEG-HSQELPW-VHLQGVQDGDLE 661
Query: 445 YYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMV 504
E +A +L L+++ V ++LQT E + E+E +K E+ K+
Sbjct: 662 ADTE-----RAARVLG--LETEHKVQLSLLQT-------ELKEEIELLKIENRNLYGKLQ 707
Query: 505 EEMQIKYQQMMEEKEKSYQEHVKQL------TEKMERERAQ-------LLEEQEKTLTSK 551
E ++K + + K ++H K+L TE M++E + + EE ++ K
Sbjct: 708 HETRLK-DDLEKVKHNLIEDHQKELNNAKQKTELMKQEFQRKETDWKVMKEELQREAEEK 766
Query: 552 LQEQARVLKERCQGESTQLQNEIQKLQKTLKK 583
L L+E+ + E + N+ + + +++
Sbjct: 767 LTLMLLELREKAESEKQTIINKFELREAEMRQ 798
Score = 32.0 bits (71), Expect = 1.7
Identities = 58/299 (19%), Positives = 130/299 (43%), Gaps = 27/299 (9%)
Query: 308 PCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYM 367
P ++ LA ++ A+Q +A +K + ++ L E+ A E+ +
Sbjct: 844 PTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQEAQEQHARELQL 903
Query: 368 KNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSK 427
L + A+L+ + + + + ALL + L+ + A + +
Sbjct: 904 LQERHQQQLL---SVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGAL 960
Query: 428 PGGYCLFIQKLQDLEKKYYEE----PRKGIQAEEILQT----YLKSKESVTDAILQTDQI 479
+ + L LE Y E + QA E+L+ L K+S+ IL +
Sbjct: 961 ETRH---LSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELE 1017
Query: 480 LTEKEKEIEVECVKAE-----SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKME 534
+++ E E++ V+ S + + + E+Q +Q ++K+ H K+ T +++
Sbjct: 1018 KLKRKHEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFGSEKKTAL-HEKEETLRLQ 1076
Query: 535 RERAQLLEEQEK-TLTSKLQE---QARVLKERCQGESTQLQ---NEIQKLQKTLKKKTK 586
+AQ ++EK +L+ +LQ+ Q + LK++ S +++ +E++ LQ+ +++ +
Sbjct: 1077 SAQAQPFHQEEKESLSLQLQKKNHQVQQLKDQVLSLSHEIEECRSELEVLQQRRERENR 1135
Score = 30.8 bits (68), Expect = 3.7
Identities = 51/230 (22%), Positives = 102/230 (44%), Gaps = 32/230 (13%)
Query: 377 LFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQ 436
L Q+KL +LD+ + Q+ S+DR L+Q EE+ I K ++
Sbjct: 1531 LLQQKLREKLDEFNE---LAIQKESADR-QVLMQEEEIKRLEEMNINIRKKVAQLQEEVE 1586
Query: 437 KLQDLEKKYYEEPRKGIQAEEILQTYLKSK-ESVTDA------------------ILQTD 477
K +++ K E+ ++ ++ +++ L S +S DA + T
Sbjct: 1587 KQKNIVKGL-EQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVTQ 1645
Query: 478 QILTEKEKEI-----EVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTE- 531
+ L +E E+ ++E +K + + +++ + +K + S +E ++ T
Sbjct: 1646 RALLRRESEVLDLKEQLEKMKGDLESKNEEILH-LNLKLDMQNSQTAVSLRELEEENTSL 1704
Query: 532 KMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTL 581
K+ R+ +EE + T+ + + Q R+ KE+ + E QL I+KLQ L
Sbjct: 1705 KVIYTRSSEIEELKATIENLQENQKRLQKEKAE-EIEQLHEVIEKLQHEL 1753
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 52.4 bits (124), Expect = 1e-06
Identities = 40/166 (24%), Positives = 89/166 (53%), Gaps = 11/166 (6%)
Query: 436 QKLQDLEKKYYE-----EPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVE 490
+K+++LE+K +E E + Q EE ++ K +E Q ++I ++EK E E
Sbjct: 344 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 403
Query: 491 CVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVK-QLTEKMERERAQLLEEQEKTLT 549
+ E + + E+M + ++M E++EK ++ K + EK RE+ + + EQE+
Sbjct: 404 EMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE--- 460
Query: 550 SKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 595
+QEQ + E+ +G+ + + ++Q+ ++ ++++ ++ + KI
Sbjct: 461 -MMQEQEEKMGEQ-EGKMCEQEAKMQEQEEKMRRQEEKIREQEKKI 504
Score = 46.6 bits (109), Expect = 6e-05
Identities = 32/152 (21%), Positives = 82/152 (53%), Gaps = 8/152 (5%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K+ + E++ E+ K + EE ++ K + I + ++++ E+E+++ + K
Sbjct: 418 EKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMC 477
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKME--RERAQLLEEQEKTL---TS 550
+A + EE + ++ + E+EK +E +++ E+ E +E+ + + EQE+ +
Sbjct: 478 EQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 537
Query: 551 KLQEQARVLK---ERCQGESTQLQNEIQKLQK 579
K+QEQ ++ E+ + + +L+ + +K+Q+
Sbjct: 538 KMQEQEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 45.8 bits (107), Expect = 1e-04
Identities = 58/305 (19%), Positives = 139/305 (45%), Gaps = 26/305 (8%)
Query: 317 LAQIENSAAVQKAIA--HYDQQMGQKVQLPAETLQELLDLHRVSEREAT---EVYMKNSF 371
L Q ++ A QK A + ++ ++ L E + + + E+ A ++ + S
Sbjct: 165 LEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESE 224
Query: 372 KDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIY------ 425
K L K+L +L++ + +Q +A +D LQ + + L+ +V+
Sbjct: 225 KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ 284
Query: 426 SKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKE- 484
+ +K+Q+ E+K E+ K + EE ++ + + + + ++++ EKE
Sbjct: 285 QQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 344
Query: 485 --KEIEVECVKAESA-QASAKMVEEMQIKYQQMMEEKE----------KSYQEHVKQLTE 531
+E+E + + E + K EE +I+ Q+ +E+E + +E +++ E
Sbjct: 345 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE 404
Query: 532 KMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQ-NEIQKLQKTLKKKTKRYMS 590
M+ + ++ E++EK + + Q + K R Q E + Q +I++ ++ ++++ +
Sbjct: 405 MMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 464
Query: 591 HKLKI 595
+ K+
Sbjct: 465 QEEKM 469
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/149 (21%), Positives = 78/149 (52%), Gaps = 7/149 (4%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K Q+ E K + + K + EE ++ + + + + + ++ + E+E+E++ + K
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTE---KMERERAQLLEEQEK--TLTS 550
+ + E+ + ++ + E+E+ QE +++ E KM + A++ E++EK
Sbjct: 436 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEE 495
Query: 551 KLQEQARVLKERCQGESTQLQNEIQKLQK 579
K++EQ + ++E Q E + Q E+ + Q+
Sbjct: 496 KIREQEKKIRE--QEEKIREQEEMMQEQE 522
Score = 40.8 bits (94), Expect = 0.004
Identities = 29/165 (17%), Positives = 85/165 (51%), Gaps = 6/165 (3%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K+++ E+ E+ K + EE + + + + + + ++ + E+EK+I + K
Sbjct: 397 EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR 456
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKME--RERAQLLEEQEKTLTSK-- 551
+ + EE + + M E+E QE +++ + E RE+ + + EQE+ + +
Sbjct: 457 EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 552 -LQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 595
+QEQ + E+ + + + + ++Q+ ++ ++++ ++ ++++
Sbjct: 517 MMQEQEEKMWEQ-EEKMCEQEEKMQEQEEKMRRQEEKMREQEVRL 560
Score = 31.6 bits (70), Expect = 2.2
Identities = 29/148 (19%), Positives = 68/148 (45%), Gaps = 9/148 (6%)
Query: 379 QKKLAAQLDKKRDDFCK-QNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQK 437
++K+ Q +K R+ K + QE ++Q E+E K G + G C K
Sbjct: 431 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ------EQEEKMG--EQEGKMCEQEAK 482
Query: 438 LQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESA 497
+Q+ E+K + K + E+ ++ + + + + ++ + E+E+++ + K +
Sbjct: 483 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 542
Query: 498 QASAKMVEEMQIKYQQMMEEKEKSYQEH 525
+ + EE + + + ++E+ QEH
Sbjct: 543 EEKMRRQEEKMREQEVRLRQQEEKMQEH 570
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 52.4 bits (124), Expect = 1e-06
Identities = 73/333 (21%), Positives = 139/333 (41%), Gaps = 57/333 (17%)
Query: 308 PCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHR-VSERE----- 361
PCM I+ QK ++ Q++ Q+ L E +L + V ERE
Sbjct: 84 PCM---------IQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIK 134
Query: 362 ---------ATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFC-------------KQNQE 399
AT Y +S ++ + + KK+ L +++D C + E
Sbjct: 135 LQADFASCTATHRYPPSSSEECEDI--KKILKHLQEQKDSQCLHVEEYQNLVKDLRVELE 192
Query: 400 ASSDRCSAL------LQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGI 453
A S++ + L++ L EE A I K + +LQ+L+ ++ E + +
Sbjct: 193 AVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTL 252
Query: 454 QAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMV-----EEMQ 508
+ ++ LQ + + + + Q L +KEKE+E + A + + K +E +
Sbjct: 253 KKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAE 312
Query: 509 IKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQAR-----VLKERC 563
K Q +K K+ E KQ E++ ++A +E+ L++ R +L ++
Sbjct: 313 CKALQAEVQKLKNSLEEAKQ-QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQ 371
Query: 564 QGESTQ-LQNEIQKLQKTLKKKTKRYMSHKLKI 595
+ ++ Q LQ E+Q LQK K S++ ++
Sbjct: 372 KADTIQELQRELQMLQKESSMAEKEQTSNRKRV 404
Score = 35.8 bits (81), Expect = 0.11
Identities = 68/331 (20%), Positives = 138/331 (41%), Gaps = 65/331 (19%)
Query: 317 LAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVY---MKNSFKD 373
L Q++NS ++ Q M ++++ + ++ D + +E +A + +KNS ++
Sbjct: 272 LTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQ--DKSKEAECKALQAEVQKLKNSLEE 329
Query: 374 VDHLFQKKLAAQLDKKRDDFCKQNQEASSDRC---SALLQVIFSPLEEEVKAGIYSKPGG 430
Q++LAAQ + CK+ EA+ C ++ L ++ KA +
Sbjct: 330 AKQ--QERLAAQQAAQ----CKE--EAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQR 381
Query: 431 YCLFIQKLQDLEKKYYEEPRKGIQAEEI--------LQTYLKSKESVTDAILQTDQILTE 482
+QK + +K RK ++ + L+ K K + + + D + +
Sbjct: 382 ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND 441
Query: 483 KEKEIE--------VECVKAESAQASAKMVEEM--QIK----YQQMME-----------E 517
I+ ++C E Q + K++E+ Q+K ++++ME +
Sbjct: 442 MLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK 501
Query: 518 KEKSYQEHVKQLTEKMERERAQL------LEEQ------EKTLTSKLQEQARVLKERCQG 565
K+K+ +E+ ++L E+ E RA+L LE + + L ++ + KE
Sbjct: 502 KDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMS 561
Query: 566 ESTQLQNEIQK----LQKTLKKKTKRYMSHK 592
QL +QK LQ T+ K+ +S K
Sbjct: 562 LQAQLDKALQKEKHYLQTTITKEAYDALSRK 592
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 52.4 bits (124), Expect = 1e-06
Identities = 73/333 (21%), Positives = 139/333 (41%), Gaps = 57/333 (17%)
Query: 308 PCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHR-VSERE----- 361
PCM I+ QK ++ Q++ Q+ L E +L + V ERE
Sbjct: 229 PCM---------IQEHQETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIK 279
Query: 362 ---------ATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFC-------------KQNQE 399
AT Y +S ++ + + KK+ L +++D C + E
Sbjct: 280 LQADFASCTATHRYPPSSSEECEDI--KKILKHLQEQKDSQCLHVEEYQNLVKDLRVELE 337
Query: 400 ASSDRCSAL------LQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGI 453
A S++ + L++ L EE A I K + +LQ+L+ ++ E + +
Sbjct: 338 AVSEQKRNIMKDMMKLELDLHGLREETSAHIERKDKDITILQCRLQELQLEFTETQKLTL 397
Query: 454 QAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMV-----EEMQ 508
+ ++ LQ + + + + Q L +KEKE+E + A + + K +E +
Sbjct: 398 KKDKFLQEKDEMLQELEKKLTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQDKSKEAE 457
Query: 509 IKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQAR-----VLKERC 563
K Q +K K+ E KQ E++ ++A +E+ L++ R +L ++
Sbjct: 458 CKALQAEVQKLKNSLEEAKQ-QERLAAQQAAQCKEEAALAGCHLEDTQRKLQKGLLLDKQ 516
Query: 564 QGESTQ-LQNEIQKLQKTLKKKTKRYMSHKLKI 595
+ ++ Q LQ E+Q LQK K S++ ++
Sbjct: 517 KADTIQELQRELQMLQKESSMAEKEQTSNRKRV 549
Score = 35.8 bits (81), Expect = 0.11
Identities = 68/331 (20%), Positives = 138/331 (41%), Gaps = 65/331 (19%)
Query: 317 LAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVY---MKNSFKD 373
L Q++NS ++ Q M ++++ + ++ D + +E +A + +KNS ++
Sbjct: 417 LTQVQNSLLKKEKELEKQQCMATELEMTVKEAKQ--DKSKEAECKALQAEVQKLKNSLEE 474
Query: 374 VDHLFQKKLAAQLDKKRDDFCKQNQEASSDRC---SALLQVIFSPLEEEVKAGIYSKPGG 430
Q++LAAQ + CK+ EA+ C ++ L ++ KA +
Sbjct: 475 AKQ--QERLAAQQAAQ----CKE--EAALAGCHLEDTQRKLQKGLLLDKQKADTIQELQR 526
Query: 431 YCLFIQKLQDLEKKYYEEPRKGIQAEEI--------LQTYLKSKESVTDAILQTDQILTE 482
+QK + +K RK ++ + L+ K K + + + D + +
Sbjct: 527 ELQMLQKESSMAEKEQTSNRKRVEELSLELSEALRKLENSDKEKRQLQKTVAEQDMKMND 586
Query: 483 KEKEIE--------VECVKAESAQASAKMVEEM--QIK----YQQMME-----------E 517
I+ ++C E Q + K++E+ Q+K ++++ME +
Sbjct: 587 MLDRIKHQHREQGSIKCKLEEDLQEATKLLEDKREQLKKSKEHEKLMEGELEALRQEFKK 646
Query: 518 KEKSYQEHVKQLTEKMERERAQL------LEEQ------EKTLTSKLQEQARVLKERCQG 565
K+K+ +E+ ++L E+ E RA+L LE + + L ++ + KE
Sbjct: 647 KDKTLKENSRKLEEENENLRAELQCCSTQLESSLNKYNTSQQVIQDLNKEIALQKESLMS 706
Query: 566 ESTQLQNEIQK----LQKTLKKKTKRYMSHK 592
QL +QK LQ T+ K+ +S K
Sbjct: 707 LQAQLDKALQKEKHYLQTTITKEAYDALSRK 737
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 51.6 bits (122), Expect = 2e-06
Identities = 33/143 (23%), Positives = 80/143 (55%), Gaps = 4/143 (2%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+++++ EKK EE + EE +Q + + + + ++ + E+E+++ + K
Sbjct: 560 ERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 619
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
+ KM E+ ++ ++Q EEK + +E + + EKM RE+ + + EQE+ + + +E+
Sbjct: 620 EQEEEDKMQEQEEMMWEQ--EEKMQEQEEKMWEQEEKM-REQEEKMREQEEKMQGQ-EEK 675
Query: 556 ARVLKERCQGESTQLQNEIQKLQ 578
R +E+ QG+ +++ + +K++
Sbjct: 676 MREQEEKMQGQEEKMREQEEKMR 698
Score = 50.8 bits (120), Expect = 3e-06
Identities = 35/147 (23%), Positives = 77/147 (52%), Gaps = 6/147 (4%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K Q+ EKK +++ K + E + + K +E Q +++ ++EK E E E
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE 599
Query: 496 SAQA----SAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSK 551
+ KM E+ + ++Q E+K + +E + + EKM+ + ++ E++EK +
Sbjct: 600 QEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEK--MRE 657
Query: 552 LQEQARVLKERCQGESTQLQNEIQKLQ 578
+E+ R +E+ QG+ +++ + +K+Q
Sbjct: 658 QEEKMREQEEKMQGQEEKMREQEEKMQ 684
Score = 48.5 bits (114), Expect = 2e-05
Identities = 38/169 (22%), Positives = 91/169 (53%), Gaps = 20/169 (11%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K+Q+ E+K E+ K + EE +Q + + + ++ + E+E+E +++ E
Sbjct: 581 EKMQEQEEKMREQEEKMWEQEEKMQEQ-------EEKMWEQEEKMWEQEEEDKMQ----E 629
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEK--SYQEHVKQLTEKMERERAQLLEEQEKT--LTSK 551
+ + E+MQ + ++M E++EK +E +++ EKM+ + ++ E++EK K
Sbjct: 630 QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEK 689
Query: 552 LQEQARVLK---ERCQGESTQLQNEIQKL--QKTLKKKTKRYMSHKLKI 595
++EQ ++ E+ G+ ++ + +K+ Q+ +++K +R K K+
Sbjct: 690 MREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKM 738
Score = 46.2 bits (108), Expect = 8e-05
Identities = 39/176 (22%), Positives = 87/176 (49%), Gaps = 17/176 (9%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++L++ EKK ++ K + EE L+ + + + ++ L E+EKE+ + +
Sbjct: 241 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELR 300
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQL--------TEKMERERAQLLEEQEKT 547
+ + E+MQ + ++M E++EK ++ K EK RE+ Q + +QE+
Sbjct: 301 EQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 360
Query: 548 L---TSKLQEQARVLKER----CQGESTQLQNEIQKLQKTLK--KKTKRYMSHKLK 594
+ +L+E+ ++E+ Q E Q + I++ +K ++ ++T R K++
Sbjct: 361 MWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQ 416
Score = 45.8 bits (107), Expect = 1e-04
Identities = 36/153 (23%), Positives = 86/153 (56%), Gaps = 10/153 (6%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++L++ E++ E+ +K Q EE ++ K++E Q ++ + E+E+ E E E
Sbjct: 514 ERLREKEERMREQ-KKMWQQEEKMREEKKTQEQEKKTWDQEEK-MREEERMREREKKMRE 571
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQ--EHVKQLTEKMERERAQLLEEQEKTLTSKLQ 553
+ + E+MQ + ++M E++EK ++ E +++ EKM + ++ E++E+ K+Q
Sbjct: 572 EEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE---DKMQ 628
Query: 554 EQARVL---KERCQGESTQLQNEIQKLQKTLKK 583
EQ ++ +E+ Q + ++ + +K+++ +K
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK 661
Score = 43.1 bits (100), Expect = 7e-04
Identities = 36/159 (22%), Positives = 82/159 (51%), Gaps = 12/159 (7%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+KL++ E++ E+ K + EE K +E + + + ++ L E+EK++ + K
Sbjct: 303 KKLREQEEQMQEQEEKMWEQEE------KMREQ-EEKMWRQEERLWEQEKQMREQEQKMR 355
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
+ +E + ++ M E+EK +++ K E+ RER + + E+E+T ++EQ
Sbjct: 356 DQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEET----MREQ 411
Query: 556 ARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLK 594
++++ + Q + E Q+ Q+ ++K K + K++
Sbjct: 412 EEKMQKQEENMWEQEEKEWQQ-QRLPEQKEKLWEQEKMQ 449
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/156 (20%), Positives = 80/156 (51%), Gaps = 14/156 (8%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLK-----SKESVTDAILQTDQILTEKEKEIEVE 490
QK++D E++ +E+ + + EE ++ K K + I + ++ + E+E+ + +
Sbjct: 352 QKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQ 411
Query: 491 CVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTS 550
K + + + EE + + Q++ E+KEK +++ EKM+ + ++ E++EK
Sbjct: 412 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ------EKMQEQEEKIWEQEEKIRDQ 465
Query: 551 KL---QEQARVLKERCQGESTQLQNEIQKLQKTLKK 583
+ QE+ +E+ + + Q+ + +K++ +K
Sbjct: 466 EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 501
Score = 42.7 bits (99), Expect = 0.001
Identities = 35/150 (23%), Positives = 79/150 (52%), Gaps = 8/150 (5%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKS--KESVTDAILQTDQILTEKEKEIEVECVK 493
+K+Q+ E+K +E+ K EE+ K +E + + Q DQ+ ++EK + E
Sbjct: 446 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE---QEDQMWEQEEKMRDQEQKM 502
Query: 494 AESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQ 553
+ + + E ++ K ++M E+K K +Q+ K EK +E+ + +QE+ + + +
Sbjct: 503 WDQEERMWEQDERLREKEERMREQK-KMWQQEEKMREEKKTQEQEKKTWDQEEKM--REE 559
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKK 583
E+ R +++ + E ++ + +K+Q+ +K
Sbjct: 560 ERMREREKKMREEEEMMREQEEKMQEQEEK 589
Score = 39.7 bits (91), Expect = 0.008
Identities = 31/137 (22%), Positives = 65/137 (47%), Gaps = 13/137 (9%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K+Q+ E+K +E+ K + EE K +E Q +++ ++EK E E
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEE------KMRE-------QEEKMQGQEEKMREQEEKMQG 685
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
+ + E+M+ + ++M ++EK + + K ++ RE+ + + +Q++ + +L E
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEH 745
Query: 556 ARVLKERCQGESTQLQN 572
E C S L N
Sbjct: 746 EERCSEPCLPPSKVLCN 762
Score = 38.5 bits (88), Expect = 0.018
Identities = 36/160 (22%), Positives = 74/160 (46%), Gaps = 7/160 (4%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++L++ EK+ E+ + Q E++ + K E Q +++ ++E+ E E E
Sbjct: 290 KELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 349
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
Q E M + + + EKE+ +E K ++ + + + + E+EK K++E+
Sbjct: 350 QEQKMRDQEERMW-EQDERLREKEERMREQEKMWEQEEKMQEEERIREREK----KMREE 404
Query: 556 ARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 595
++E Q E Q Q E Q+ + + +R K K+
Sbjct: 405 EETMRE--QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 442
Score = 37.7 bits (86), Expect = 0.030
Identities = 39/160 (24%), Positives = 82/160 (51%), Gaps = 12/160 (7%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKE---KEIEVECV 492
+K+++ E+K + + + + E+ ++ + + + + D+ L EKE +E E
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 383
Query: 493 KAESAQASAKMVE---EMQIKYQQMMEEKEKSYQEHVKQLTEKMERE-RAQLLEEQEKTL 548
+ E Q ++ E +M+ + + M E++EK Q+ + + E+ E+E + Q L EQ++ L
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEK-MQKQEENMWEQEEKEWQQQRLPEQKEKL 442
Query: 549 --TSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTK 586
K+QEQ + E Q E + Q E+ +K + ++ K
Sbjct: 443 WEQEKMQEQEEKIWE--QEEKIRDQEEMWGQEKKMWRQEK 480
Score = 37.4 bits (85), Expect = 0.039
Identities = 34/138 (24%), Positives = 71/138 (51%), Gaps = 21/138 (15%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K++D E+K +++ + + +E L+ KE ++ + + ++E+++ E K
Sbjct: 493 EKMRDQEQKMWDQEERMWEQDE----RLREKEER----MREQKKMWQQEEKMREE--KKT 542
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
Q +E +++ ++ M E+EK +E E+M RE+ + ++EQE+ K++EQ
Sbjct: 543 QEQEKKTWDQEEKMREEERMREREKKMREE-----EEMMREQEEKMQEQEE----KMREQ 593
Query: 556 ARVLKERCQGESTQLQNE 573
+ E Q E Q Q E
Sbjct: 594 EEKMWE--QEEKMQEQEE 609
Score = 37.0 bits (84), Expect = 0.051
Identities = 29/125 (23%), Positives = 64/125 (51%), Gaps = 14/125 (11%)
Query: 468 SVTDAILQTDQILTEKEKEIEVECVK-------AESAQASAKMVEEMQIKYQQMMEEKEK 520
++ + + + ++ L E+EK+I + K + + EE + ++ + E+EK
Sbjct: 231 TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEK 290
Query: 521 SYQEHVKQLTE-KMERERAQLLEEQEKTL---TSKLQEQARVL---KERCQGESTQLQNE 573
+E K+L E K RE+ + ++EQE+ + K++EQ + +ER + Q++ +
Sbjct: 291 ELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ 350
Query: 574 IQKLQ 578
QK++
Sbjct: 351 EQKMR 355
Score = 36.2 bits (82), Expect = 0.088
Identities = 32/152 (21%), Positives = 78/152 (51%), Gaps = 8/152 (5%)
Query: 450 RKGIQAEEILQTYLKSKESVTDAILQTDQI-LTEKEKEIEVECVKAESAQASAKMVEEMQ 508
R I EE+ + + +E + A + +I L KE + ++E K Q ++E
Sbjct: 177 RNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEM 236
Query: 509 IKYQQMMEEKEKSYQEHVKQLTEKMERERAQ--LLEEQEKTL---TSKLQEQARVLKERC 563
+ ++ + E+EK ++ +++ + ER R Q + EQE+ + +L+EQ + L+E
Sbjct: 237 WRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELRE-- 294
Query: 564 QGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 595
Q + + Q ++++ ++ ++++ ++ + K+
Sbjct: 295 QEKELREQKKLREQEEQMQEQEEKMWEQEEKM 326
Score = 36.2 bits (82), Expect = 0.088
Identities = 32/161 (19%), Positives = 83/161 (51%), Gaps = 11/161 (6%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
Q+L + ++K +E+ + Q E+I + +E + D + + +EK++ + E
Sbjct: 433 QRLPEQKEKLWEQEKMQEQEEKIWE----QEEKIRD-----QEEMWGQEKKMWRQEKMRE 483
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQ-LLEEQEKTLTSKLQE 554
+ E+M+ + Q+M +++E+ +++ ++L EK ER R Q + +QE+ + + +
Sbjct: 484 QEDQMWEQEEKMRDQEQKMWDQEERMWEQD-ERLREKEERMREQKKMWQQEEKMREEKKT 542
Query: 555 QARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI 595
Q + K Q E + + +++ +K ++++ + + K+
Sbjct: 543 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 583
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 51.2 bits (121), Expect = 3e-06
Identities = 49/247 (19%), Positives = 116/247 (46%), Gaps = 11/247 (4%)
Query: 335 QQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFC 394
QQ +++Q Q++L +++ E + + + L Q++L Q ++ +
Sbjct: 171 QQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQ--QQQEQLQQQQLLQQQEQLQQQQF 228
Query: 395 KQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQ 454
+Q QE + LL L++++ ++ L Q+ Q L+++ + ++ +Q
Sbjct: 229 QQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQ-LQQQLLLQQQEQLQ 287
Query: 455 AEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECV------KAESAQASAKMVEEMQ 508
++ Q + +E + LQ + E+E+E+E+E + + E Q ++ + +
Sbjct: 288 QQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQE 347
Query: 509 IKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGEST 568
++ QQ + + QE ++QL +++E+++ QL EQ++ + ++ Q E T
Sbjct: 348 LERQQEQRQLQLKLQEELQQLEQQLEQQQQQL--EQQEVQLELTPVELGAQQQEVQLELT 405
Query: 569 QLQNEIQ 575
+Q E+Q
Sbjct: 406 PVQPELQ 412
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/122 (22%), Positives = 70/122 (57%), Gaps = 4/122 (3%)
Query: 474 LQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKM 533
LQ Q+ ++++ ++ + + ++ QA + V + Q + QQ ++E++ Q+ + +++
Sbjct: 159 LQPQQV--QEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQL 216
Query: 534 ERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQ--LQNEIQKLQKTLKKKTKRYMSH 591
+++ QL ++Q + +LQ+Q ++L + QG+ Q LQ + +LQ+ L ++ + +
Sbjct: 217 LQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQ 276
Query: 592 KL 593
+L
Sbjct: 277 QL 278
Score = 42.4 bits (98), Expect = 0.001
Identities = 46/251 (18%), Positives = 117/251 (46%), Gaps = 20/251 (7%)
Query: 335 QQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNS-FKDVDHLFQKKLAAQLDKKRDDF 393
Q M Q+ QL + +QE L + E+ T+ + + + L Q+ QL +++ +
Sbjct: 151 QLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQ 210
Query: 394 CKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGI 453
+Q Q L Q F +E+++ L +Q+ L+++ ++ + +
Sbjct: 211 LQQQQLLQQQE--QLQQQQFQQQQEQLQQQ------QQLLLLQQQGQLQQQLLQQQQAQL 262
Query: 454 QAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQ 513
Q + + Q + ++ + +LQ + L +++++ + Q + +++ Q++
Sbjct: 263 QQQLLEQQQAQLQQQL---LLQQQEQLQQQQQQ--------QLLQQQQEQLQQQQLQPPP 311
Query: 514 MMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNE 573
+ E+E+ + + + E+E Q +E E+ + Q++ R L+ + Q E QL+ +
Sbjct: 312 LEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQLEQQ 371
Query: 574 IQKLQKTLKKK 584
+++ Q+ L+++
Sbjct: 372 LEQQQQQLEQQ 382
Score = 36.2 bits (82), Expect = 0.088
Identities = 45/202 (22%), Positives = 95/202 (47%), Gaps = 26/202 (12%)
Query: 396 QNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQA 455
Q + +S R + V S + EE ++PG L +Q+L+ EP++ Q
Sbjct: 58 QERNSSPQRPAVSAPVGASEIAEE------TRPGQRELQLQQLEQ-----QPEPQQQPQH 106
Query: 456 EEILQT--YLK-SKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQ 512
E++ Q +L+ ++ D Q Q+ EK + + + +K E M ++ Q++ Q
Sbjct: 107 EQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQL----MHQQQQLQPQ 162
Query: 513 QMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQN 572
Q+ E++ Q+ Q + E+ Q+L++QE+ LQ+Q + + Q + Q
Sbjct: 163 QVQEQQRLQQQQEQLQTQQAQEQ---QVLQQQEQ-----LQQQVQEQQLLQQQQEQLQQQ 214
Query: 573 EIQKLQKTLKKKTKRYMSHKLK 594
++ + Q+ L+++ + +L+
Sbjct: 215 QLLQQQEQLQQQQFQQQQEQLQ 236
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 51.2 bits (121), Expect = 3e-06
Identities = 72/318 (22%), Positives = 137/318 (43%), Gaps = 33/318 (10%)
Query: 292 ESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQEL 351
E VL + + E A A Q E AA + +++ Q + A+ +
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 352 LDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQV 411
+EA + + + + L QK+ A +K F +Q R A ++
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL-----RQKAQVEQ 2186
Query: 412 IFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTY--------- 462
+ L +++ + K L ++LQ L+ + E R+ Q EE L +
Sbjct: 2187 ELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242
Query: 463 LKSK-ESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
LK++ E+ A++ D+ T++ + E E +K + +A+ V + + + E++ +
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 522 YQEHV--KQLTEKME--------RERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQ 571
Q + K L EKM+ + A+LL++Q++ QEQAR L+E + + QL
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQEDKEQMAQQLA 2358
Query: 572 NEIQKLQKTLKKKTKRYM 589
E Q Q+TL+ + +R +
Sbjct: 2359 EETQGFQRTLEAERQRQL 2376
Score = 47.0 bits (110), Expect = 5e-05
Identities = 59/315 (18%), Positives = 128/315 (40%), Gaps = 44/315 (13%)
Query: 311 ENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSE------REATE 364
EN L L +N+ + A +Q+ ++ + QE L +++E R E
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309
Query: 365 VYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKA-- 422
+K + V + K A+L +++ + ++ + + Q L EE +
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ----QLAEETQGFQ 2365
Query: 423 -GIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILT 481
+ ++ + + L+ + E R +AEE Q + K E + + + +T+
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425
Query: 482 EK--------------------------EKEIEVECVKAESAQASAKMVEEMQIKYQQMM 515
EK E E E E ++ E+ K E ++ +Q++
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485
Query: 516 EEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ---ARVLKERCQGESTQLQN 572
+E + Q + + ++RER +E+++ L Q++ A+ L+E Q + Q++
Sbjct: 2486 QETQALQQSFLSEKDSLLQRER--FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 573 EIQKLQKTLKKKTKR 587
E Q+L ++++ +R
Sbjct: 2544 ERQRLVASMEEARRR 2558
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/149 (22%), Positives = 79/149 (53%), Gaps = 11/149 (7%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++L++ + E K Q ++LQ LKS+E T +Q +Q+L E + + + +
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQT---VQQEQLLQETQALQQSFLSEKD 2500
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
S + +E+ + K +Q+ +++ Q QL E+ +R++ Q+ +E+++ + S E+
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVAS--MEE 2554
Query: 556 ARVLKERCQGESTQLQNEIQKLQKTLKKK 584
AR + + + Q E+Q+L++ +++
Sbjct: 2555 ARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/153 (25%), Positives = 73/153 (47%), Gaps = 19/153 (12%)
Query: 436 QKLQDLEK--KYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK 493
+KLQ K + E + +Q E++LQ +++ + L L ++E+ IE E K
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 494 AESA----QASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLT 549
E A A+ + E Q + QQ ME++ + +L ME R + E +E
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGV-- 2566
Query: 550 SKLQEQARVLKERCQGESTQLQNEIQKLQKTLK 582
+ QE+ + L+++ + + L E Q+L++ L+
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Score = 38.5 bits (88), Expect = 0.018
Identities = 48/215 (22%), Positives = 98/215 (45%), Gaps = 31/215 (14%)
Query: 350 ELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALL 409
EL +V+ + E+ + S D + L ++ A+L+++++ K QEA LL
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERL--REAIAELEREKE---KLQQEAK------LL 2469
Query: 410 QVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEIL-QTYLKSKES 468
Q L+ E + + +Q+ Q L++ + E +Q E + Q K ++
Sbjct: 2470 Q-----LKSEEMQTVQQEQ-----LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 469 VTDAILQTDQILTEKEKE---IEVE----CVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
D + + Q+ E++++ +E E E A+ EE + Q+ +++ E+
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Query: 522 YQEHVKQLTEKMER--ERAQLLEEQEKTLTSKLQE 554
++ + L E+ +R E+ QLLEEQ + + +E
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 38.1 bits (87), Expect = 0.023
Identities = 33/122 (27%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 463 LKSKESVTDAILQTDQILTEKEKEI-EVECVKAESAQASAKMVEEMQIKYQQMMEEKE-- 519
L+SKE + Q+ E+E+ E E E Q S EE + + +EE E
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAE----ERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 520 KSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQK 579
K+ E ++L E+ E+E A+ L+ ++ +LQ + + Q + +LQ +Q+ Q
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 580 TL 581
L
Sbjct: 2075 VL 2076
Score = 36.6 bits (83), Expect = 0.067
Identities = 63/290 (21%), Positives = 120/290 (41%), Gaps = 35/290 (12%)
Query: 321 ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQK 380
E +A A + ++ Q AE L+ + +R+A EV + + K ++
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAARE 1530
Query: 381 KLAA-----QLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFI 435
K A +L + ++ ++ ++A +R + QV + +A + SK F
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRAS---FA 1586
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K LE+ EE Q E + + + + ++ E E+E+E +KA
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-------EAERAREEAERELERWQLKAN 1639
Query: 496 SAQASAKMVEEM-------QIKYQQMMEEKE-------KSYQEHVKQ--LTEKMERERAQ 539
A EE+ Q + ++ EE E K+ ++ V+Q L E+ ++ Q
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 540 LLEEQEKTLTSKLQEQARVLKERCQGESTQ--LQNEIQKLQKTLKKKTKR 587
L E + + QE R+ E QGE + L+ E+ +LQ+ T++
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Score = 35.8 bits (81), Expect = 0.11
Identities = 36/153 (23%), Positives = 73/153 (47%), Gaps = 16/153 (10%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++ ++L+++ EE ++ EE + K S+ + + Q Q E EI+ + +AE
Sbjct: 1388 REAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAE 1441
Query: 496 SAQASAKMVEE--MQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQ 553
+A+ S +EE ++ Q E+++ E Q R RA+ E Q++ + Q
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL----RARAEEAEAQKR----QAQ 1493
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKKTK 586
E+A L+ + Q ES + + +L +K + +
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Score = 35.4 bits (80), Expect = 0.15
Identities = 32/153 (20%), Positives = 70/153 (45%), Gaps = 20/153 (13%)
Query: 447 EEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEE 506
++P+ +E ++Q Y+ + ++ T Q + + + +M EE
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR-------------RMEEE 1347
Query: 507 MQIKYQQMMEEKEKSYQ-----EHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKE 561
++ QQ EE+E+ + E +QL E + +AQ E + K L ++QE+ V +E
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREAKELQQRMQEEV-VRRE 1405
Query: 562 RCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLK 594
++ Q + IQ+ + L++ ++ + K +
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438
Score = 33.5 bits (75), Expect = 0.57
Identities = 38/151 (25%), Positives = 65/151 (43%), Gaps = 18/151 (11%)
Query: 450 RKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK--AESAQASAKMVEEM 507
R+ +AE +L L + T L+T+ + KEKE E E ++ AE + +EE
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATR--LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1883
Query: 508 QIKYQQMMEEK-------EKSYQEHVKQLTEKMERERAQLLEE-------QEKTLTSKLQ 553
+++ +EE+ S E K L E R+R Q+ EE EK K +
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKK 584
+ + + R E T E +L+ +++
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Score = 33.1 bits (74), Expect = 0.74
Identities = 35/143 (24%), Positives = 63/143 (44%), Gaps = 28/143 (19%)
Query: 474 LQTDQILTEKEKEIEVECVKAESAQASAKMVE------EMQIKYQQMMEEKEKSYQE--H 525
L D + ++ E E+ +KA +A+A E ++ + + KE++ E
Sbjct: 1912 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971
Query: 526 VKQLTEKMERERAQLLEEQEKTLTSKLQ-------------------EQARVLKERCQGE 566
+QL + ER R + E +K+L ++ + E+AR L+ER + E
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2031
Query: 567 ST-QLQNEIQKLQKTLKKKTKRY 588
S QLQ + QK L+ + K +
Sbjct: 2032 SARQLQLAQEAAQKRLQAEEKAH 2054
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 51.2 bits (121), Expect = 3e-06
Identities = 72/318 (22%), Positives = 137/318 (43%), Gaps = 33/318 (10%)
Query: 292 ESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQEL 351
E VL + + E A A Q E AA + +++ Q + A+ +
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2135
Query: 352 LDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQV 411
+EA + + + + L QK+ A +K F +Q R A ++
Sbjct: 2136 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL-----RQKAQVEQ 2190
Query: 412 IFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTY--------- 462
+ L +++ + K L ++LQ L+ + E R+ Q EE L +
Sbjct: 2191 ELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2246
Query: 463 LKSK-ESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
LK++ E+ A++ D+ T++ + E E +K + +A+ V + + + E++ +
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2306
Query: 522 YQEHV--KQLTEKME--------RERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQ 571
Q + K L EKM+ + A+LL++Q++ QEQAR L+E + + QL
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQEDKEQMAQQLA 2362
Query: 572 NEIQKLQKTLKKKTKRYM 589
E Q Q+TL+ + +R +
Sbjct: 2363 EETQGFQRTLEAERQRQL 2380
Score = 47.0 bits (110), Expect = 5e-05
Identities = 59/315 (18%), Positives = 128/315 (40%), Gaps = 44/315 (13%)
Query: 311 ENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSE------REATE 364
EN L L +N+ + A +Q+ ++ + QE L +++E R E
Sbjct: 2254 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2313
Query: 365 VYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKA-- 422
+K + V + K A+L +++ + ++ + + Q L EE +
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ----QLAEETQGFQ 2369
Query: 423 -GIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILT 481
+ ++ + + L+ + E R +AEE Q + K E + + + +T+
Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2429
Query: 482 EK--------------------------EKEIEVECVKAESAQASAKMVEEMQIKYQQMM 515
EK E E E E ++ E+ K E ++ +Q++
Sbjct: 2430 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2489
Query: 516 EEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ---ARVLKERCQGESTQLQN 572
+E + Q + + ++RER +E+++ L Q++ A+ L+E Q + Q++
Sbjct: 2490 QETQALQQSFLSEKDSLLQRER--FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 573 EIQKLQKTLKKKTKR 587
E Q+L ++++ +R
Sbjct: 2548 ERQRLVASMEEARRR 2562
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/149 (22%), Positives = 79/149 (53%), Gaps = 11/149 (7%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++L++ + E K Q ++LQ LKS+E T +Q +Q+L E + + + +
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQT---VQQEQLLQETQALQQSFLSEKD 2504
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
S + +E+ + K +Q+ +++ Q QL E+ +R++ Q+ +E+++ + S E+
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVAS--MEE 2558
Query: 556 ARVLKERCQGESTQLQNEIQKLQKTLKKK 584
AR + + + Q E+Q+L++ +++
Sbjct: 2559 ARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2587
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/153 (25%), Positives = 73/153 (47%), Gaps = 19/153 (12%)
Query: 436 QKLQDLEK--KYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK 493
+KLQ K + E + +Q E++LQ +++ + L L ++E+ IE E K
Sbjct: 2464 EKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQEKAK 2519
Query: 494 AESA----QASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLT 549
E A A+ + E Q + QQ ME++ + +L ME R + E +E
Sbjct: 2520 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGV-- 2570
Query: 550 SKLQEQARVLKERCQGESTQLQNEIQKLQKTLK 582
+ QE+ + L+++ + + L E Q+L++ L+
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2603
Score = 38.5 bits (88), Expect = 0.018
Identities = 48/215 (22%), Positives = 98/215 (45%), Gaps = 31/215 (14%)
Query: 350 ELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALL 409
EL +V+ + E+ + S D + L ++ A+L+++++ K QEA LL
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSDHDAERL--REAIAELEREKE---KLQQEAK------LL 2473
Query: 410 QVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEIL-QTYLKSKES 468
Q L+ E + + +Q+ Q L++ + E +Q E + Q K ++
Sbjct: 2474 Q-----LKSEEMQTVQQEQ-----LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2523
Query: 469 VTDAILQTDQILTEKEKE---IEVE----CVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
D + + Q+ E++++ +E E E A+ EE + Q+ +++ E+
Sbjct: 2524 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2583
Query: 522 YQEHVKQLTEKMER--ERAQLLEEQEKTLTSKLQE 554
++ + L E+ +R E+ QLLEEQ + + +E
Sbjct: 2584 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2618
Score = 38.1 bits (87), Expect = 0.023
Identities = 33/122 (27%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 463 LKSKESVTDAILQTDQILTEKEKEI-EVECVKAESAQASAKMVEEMQIKYQQMMEEKE-- 519
L+SKE + Q+ E+E+ E E E Q S EE + + +EE E
Sbjct: 1963 LRSKEQAELEAARQRQLAAEEERRRREAE----ERVQKSLAAEEEAARQRKAALEEVERL 2018
Query: 520 KSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQK 579
K+ E ++L E+ E+E A+ L+ ++ +LQ + + Q + +LQ +Q+ Q
Sbjct: 2019 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Query: 580 TL 581
L
Sbjct: 2079 VL 2080
Score = 36.6 bits (83), Expect = 0.067
Identities = 63/290 (21%), Positives = 120/290 (41%), Gaps = 35/290 (12%)
Query: 321 ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQK 380
E +A A + ++ Q AE L+ + +R+A EV + + K ++
Sbjct: 1476 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAARE 1534
Query: 381 KLAA-----QLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFI 435
K A +L + ++ ++ ++A +R + QV + +A + SK F
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRAS---FA 1590
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K LE+ EE Q E + + + + ++ E E+E+E +KA
Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-------EAERAREEAERELERWQLKAN 1643
Query: 496 SAQASAKMVEEM-------QIKYQQMMEEKE-------KSYQEHVKQ--LTEKMERERAQ 539
A EE+ Q + ++ EE E K+ ++ V+Q L E+ ++ Q
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703
Query: 540 LLEEQEKTLTSKLQEQARVLKERCQGESTQ--LQNEIQKLQKTLKKKTKR 587
L E + + QE R+ E QGE + L+ E+ +LQ+ T++
Sbjct: 1704 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1753
Score = 35.8 bits (81), Expect = 0.11
Identities = 36/153 (23%), Positives = 73/153 (47%), Gaps = 16/153 (10%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++ ++L+++ EE ++ EE + K S+ + + Q Q E EI+ + +AE
Sbjct: 1392 REAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAE 1445
Query: 496 SAQASAKMVEE--MQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQ 553
+A+ S +EE ++ Q E+++ E Q R RA+ E Q++ + Q
Sbjct: 1446 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL----RARAEEAEAQKR----QAQ 1497
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKKTK 586
E+A L+ + Q ES + + +L +K + +
Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530
Score = 35.4 bits (80), Expect = 0.15
Identities = 32/153 (20%), Positives = 70/153 (45%), Gaps = 20/153 (13%)
Query: 447 EEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEE 506
++P+ +E ++Q Y+ + ++ T Q + + + +M EE
Sbjct: 1305 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR-------------RMEEE 1351
Query: 507 MQIKYQQMMEEKEKSYQ-----EHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKE 561
++ QQ EE+E+ + E +QL E + +AQ E + K L ++QE+ V +E
Sbjct: 1352 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREAKELQQRMQEEV-VRRE 1409
Query: 562 RCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLK 594
++ Q + IQ+ + L++ ++ + K +
Sbjct: 1410 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1442
Score = 33.5 bits (75), Expect = 0.57
Identities = 38/151 (25%), Positives = 65/151 (43%), Gaps = 18/151 (11%)
Query: 450 RKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK--AESAQASAKMVEEM 507
R+ +AE +L L + T L+T+ + KEKE E E ++ AE + +EE
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATR--LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1887
Query: 508 QIKYQQMMEEK-------EKSYQEHVKQLTEKMERERAQLLEE-------QEKTLTSKLQ 553
+++ +EE+ S E K L E R+R Q+ EE EK K +
Sbjct: 1888 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1947
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKK 584
+ + + R E T E +L+ +++
Sbjct: 1948 LELELGRIRSNAEDTLRSKEQAELEAARQRQ 1978
Score = 33.1 bits (74), Expect = 0.74
Identities = 35/143 (24%), Positives = 63/143 (44%), Gaps = 28/143 (19%)
Query: 474 LQTDQILTEKEKEIEVECVKAESAQASAKMVE------EMQIKYQQMMEEKEKSYQE--H 525
L D + ++ E E+ +KA +A+A E ++ + + KE++ E
Sbjct: 1916 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1975
Query: 526 VKQLTEKMERERAQLLEEQEKTLTSKLQ-------------------EQARVLKERCQGE 566
+QL + ER R + E +K+L ++ + E+AR L+ER + E
Sbjct: 1976 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2035
Query: 567 ST-QLQNEIQKLQKTLKKKTKRY 588
S QLQ + QK L+ + K +
Sbjct: 2036 SARQLQLAQEAAQKRLQAEEKAH 2058
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 51.2 bits (121), Expect = 3e-06
Identities = 72/318 (22%), Positives = 137/318 (43%), Gaps = 33/318 (10%)
Query: 292 ESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQEL 351
E VL + + E A A Q E AA + +++ Q + A+ +
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 352 LDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQV 411
+EA + + + + L QK+ A +K F +Q R A ++
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL-----RQKAQVEQ 2186
Query: 412 IFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTY--------- 462
+ L +++ + K L ++LQ L+ + E R+ Q EE L +
Sbjct: 2187 ELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242
Query: 463 LKSK-ESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
LK++ E+ A++ D+ T++ + E E +K + +A+ V + + + E++ +
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 522 YQEHV--KQLTEKME--------RERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQ 571
Q + K L EKM+ + A+LL++Q++ QEQAR L+E + + QL
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQEDKEQMAQQLA 2358
Query: 572 NEIQKLQKTLKKKTKRYM 589
E Q Q+TL+ + +R +
Sbjct: 2359 EETQGFQRTLEAERQRQL 2376
Score = 47.0 bits (110), Expect = 5e-05
Identities = 59/315 (18%), Positives = 128/315 (40%), Gaps = 44/315 (13%)
Query: 311 ENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSE------REATE 364
EN L L +N+ + A +Q+ ++ + QE L +++E R E
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309
Query: 365 VYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKA-- 422
+K + V + K A+L +++ + ++ + + Q L EE +
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ----QLAEETQGFQ 2365
Query: 423 -GIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILT 481
+ ++ + + L+ + E R +AEE Q + K E + + + +T+
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2425
Query: 482 EK--------------------------EKEIEVECVKAESAQASAKMVEEMQIKYQQMM 515
EK E E E E ++ E+ K E ++ +Q++
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485
Query: 516 EEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ---ARVLKERCQGESTQLQN 572
+E + Q + + ++RER +E+++ L Q++ A+ L+E Q + Q++
Sbjct: 2486 QETQALQQSFLSEKDSLLQRER--FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 573 EIQKLQKTLKKKTKR 587
E Q+L ++++ +R
Sbjct: 2544 ERQRLVASMEEARRR 2558
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/149 (22%), Positives = 79/149 (53%), Gaps = 11/149 (7%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++L++ + E K Q ++LQ LKS+E T +Q +Q+L E + + + +
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQT---VQQEQLLQETQALQQSFLSEKD 2500
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
S + +E+ + K +Q+ +++ Q QL E+ +R++ Q+ +E+++ + S E+
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVAS--MEE 2554
Query: 556 ARVLKERCQGESTQLQNEIQKLQKTLKKK 584
AR + + + Q E+Q+L++ +++
Sbjct: 2555 ARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2583
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/153 (25%), Positives = 73/153 (47%), Gaps = 19/153 (12%)
Query: 436 QKLQDLEK--KYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK 493
+KLQ K + E + +Q E++LQ +++ + L L ++E+ IE E K
Sbjct: 2460 EKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 494 AESA----QASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLT 549
E A A+ + E Q + QQ ME++ + +L ME R + E +E
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGV-- 2566
Query: 550 SKLQEQARVLKERCQGESTQLQNEIQKLQKTLK 582
+ QE+ + L+++ + + L E Q+L++ L+
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2599
Score = 38.5 bits (88), Expect = 0.018
Identities = 48/215 (22%), Positives = 98/215 (45%), Gaps = 31/215 (14%)
Query: 350 ELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALL 409
EL +V+ + E+ + S D + L ++ A+L+++++ K QEA LL
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERL--REAIAELEREKE---KLQQEAK------LL 2469
Query: 410 QVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEIL-QTYLKSKES 468
Q L+ E + + +Q+ Q L++ + E +Q E + Q K ++
Sbjct: 2470 Q-----LKSEEMQTVQQEQ-----LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2519
Query: 469 VTDAILQTDQILTEKEKE---IEVE----CVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
D + + Q+ E++++ +E E E A+ EE + Q+ +++ E+
Sbjct: 2520 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Query: 522 YQEHVKQLTEKMER--ERAQLLEEQEKTLTSKLQE 554
++ + L E+ +R E+ QLLEEQ + + +E
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2614
Score = 38.1 bits (87), Expect = 0.023
Identities = 33/122 (27%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 463 LKSKESVTDAILQTDQILTEKEKEI-EVECVKAESAQASAKMVEEMQIKYQQMMEEKE-- 519
L+SKE + Q+ E+E+ E E E Q S EE + + +EE E
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAE----ERVQKSLAAEEEAARQRKAALEEVERL 2014
Query: 520 KSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQK 579
K+ E ++L E+ E+E A+ L+ ++ +LQ + + Q + +LQ +Q+ Q
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 580 TL 581
L
Sbjct: 2075 VL 2076
Score = 36.6 bits (83), Expect = 0.067
Identities = 63/290 (21%), Positives = 120/290 (41%), Gaps = 35/290 (12%)
Query: 321 ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQK 380
E +A A + ++ Q AE L+ + +R+A EV + + K ++
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAARE 1530
Query: 381 KLAA-----QLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFI 435
K A +L + ++ ++ ++A +R + QV + +A + SK F
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRAS---FA 1586
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K LE+ EE Q E + + + + ++ E E+E+E +KA
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-------EAERAREEAERELERWQLKAN 1639
Query: 496 SAQASAKMVEEM-------QIKYQQMMEEKE-------KSYQEHVKQ--LTEKMERERAQ 539
A EE+ Q + ++ EE E K+ ++ V+Q L E+ ++ Q
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 540 LLEEQEKTLTSKLQEQARVLKERCQGESTQ--LQNEIQKLQKTLKKKTKR 587
L E + + QE R+ E QGE + L+ E+ +LQ+ T++
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Score = 35.8 bits (81), Expect = 0.11
Identities = 36/153 (23%), Positives = 73/153 (47%), Gaps = 16/153 (10%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++ ++L+++ EE ++ EE + K S+ + + Q Q E EI+ + +AE
Sbjct: 1388 REAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAE 1441
Query: 496 SAQASAKMVEE--MQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQ 553
+A+ S +EE ++ Q E+++ E Q R RA+ E Q++ + Q
Sbjct: 1442 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL----RARAEEAEAQKR----QAQ 1493
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKKTK 586
E+A L+ + Q ES + + +L +K + +
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Score = 35.4 bits (80), Expect = 0.15
Identities = 32/153 (20%), Positives = 70/153 (45%), Gaps = 20/153 (13%)
Query: 447 EEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEE 506
++P+ +E ++Q Y+ + ++ T Q + + + +M EE
Sbjct: 1301 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR-------------RMEEE 1347
Query: 507 MQIKYQQMMEEKEKSYQ-----EHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKE 561
++ QQ EE+E+ + E +QL E + +AQ E + K L ++QE+ V +E
Sbjct: 1348 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREAKELQQRMQEEV-VRRE 1405
Query: 562 RCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLK 594
++ Q + IQ+ + L++ ++ + K +
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438
Score = 33.5 bits (75), Expect = 0.57
Identities = 38/151 (25%), Positives = 65/151 (43%), Gaps = 18/151 (11%)
Query: 450 RKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK--AESAQASAKMVEEM 507
R+ +AE +L L + T L+T+ + KEKE E E ++ AE + +EE
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATR--LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1883
Query: 508 QIKYQQMMEEK-------EKSYQEHVKQLTEKMERERAQLLEE-------QEKTLTSKLQ 553
+++ +EE+ S E K L E R+R Q+ EE EK K +
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKK 584
+ + + R E T E +L+ +++
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Score = 33.1 bits (74), Expect = 0.74
Identities = 35/143 (24%), Positives = 63/143 (44%), Gaps = 28/143 (19%)
Query: 474 LQTDQILTEKEKEIEVECVKAESAQASAKMVE------EMQIKYQQMMEEKEKSYQE--H 525
L D + ++ E E+ +KA +A+A E ++ + + KE++ E
Sbjct: 1912 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1971
Query: 526 VKQLTEKMERERAQLLEEQEKTLTSKLQ-------------------EQARVLKERCQGE 566
+QL + ER R + E +K+L ++ + E+AR L+ER + E
Sbjct: 1972 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2031
Query: 567 ST-QLQNEIQKLQKTLKKKTKRY 588
S QLQ + QK L+ + K +
Sbjct: 2032 SARQLQLAQEAAQKRLQAEEKAH 2054
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 51.2 bits (121), Expect = 3e-06
Identities = 72/318 (22%), Positives = 137/318 (43%), Gaps = 33/318 (10%)
Query: 292 ESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQEL 351
E VL + + E A A Q E AA + +++ Q + A+ +
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2099
Query: 352 LDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQV 411
+EA + + + + L QK+ A +K F +Q R A ++
Sbjct: 2100 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL-----RQKAQVEQ 2154
Query: 412 IFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTY--------- 462
+ L +++ + K L ++LQ L+ + E R+ Q EE L +
Sbjct: 2155 ELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2210
Query: 463 LKSK-ESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
LK++ E+ A++ D+ T++ + E E +K + +A+ V + + + E++ +
Sbjct: 2211 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2270
Query: 522 YQEHV--KQLTEKME--------RERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQ 571
Q + K L EKM+ + A+LL++Q++ QEQAR L+E + + QL
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQEDKEQMAQQLA 2326
Query: 572 NEIQKLQKTLKKKTKRYM 589
E Q Q+TL+ + +R +
Sbjct: 2327 EETQGFQRTLEAERQRQL 2344
Score = 47.0 bits (110), Expect = 5e-05
Identities = 59/315 (18%), Positives = 128/315 (40%), Gaps = 44/315 (13%)
Query: 311 ENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSE------REATE 364
EN L L +N+ + A +Q+ ++ + QE L +++E R E
Sbjct: 2218 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2277
Query: 365 VYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKA-- 422
+K + V + K A+L +++ + ++ + + Q L EE +
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ----QLAEETQGFQ 2333
Query: 423 -GIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILT 481
+ ++ + + L+ + E R +AEE Q + K E + + + +T+
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2393
Query: 482 EK--------------------------EKEIEVECVKAESAQASAKMVEEMQIKYQQMM 515
EK E E E E ++ E+ K E ++ +Q++
Sbjct: 2394 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2453
Query: 516 EEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ---ARVLKERCQGESTQLQN 572
+E + Q + + ++RER +E+++ L Q++ A+ L+E Q + Q++
Sbjct: 2454 QETQALQQSFLSEKDSLLQRER--FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 573 EIQKLQKTLKKKTKR 587
E Q+L ++++ +R
Sbjct: 2512 ERQRLVASMEEARRR 2526
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/149 (22%), Positives = 79/149 (53%), Gaps = 11/149 (7%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++L++ + E K Q ++LQ LKS+E T +Q +Q+L E + + + +
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQT---VQQEQLLQETQALQQSFLSEKD 2468
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
S + +E+ + K +Q+ +++ Q QL E+ +R++ Q+ +E+++ + S E+
Sbjct: 2469 SLLQRERFIEQEKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVAS--MEE 2522
Query: 556 ARVLKERCQGESTQLQNEIQKLQKTLKKK 584
AR + + + Q E+Q+L++ +++
Sbjct: 2523 ARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2551
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/153 (25%), Positives = 73/153 (47%), Gaps = 19/153 (12%)
Query: 436 QKLQDLEK--KYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK 493
+KLQ K + E + +Q E++LQ +++ + L L ++E+ IE E K
Sbjct: 2428 EKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQEKAK 2483
Query: 494 AESA----QASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLT 549
E A A+ + E Q + QQ ME++ + +L ME R + E +E
Sbjct: 2484 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGV-- 2534
Query: 550 SKLQEQARVLKERCQGESTQLQNEIQKLQKTLK 582
+ QE+ + L+++ + + L E Q+L++ L+
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2567
Score = 38.5 bits (88), Expect = 0.018
Identities = 48/215 (22%), Positives = 98/215 (45%), Gaps = 31/215 (14%)
Query: 350 ELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALL 409
EL +V+ + E+ + S D + L ++ A+L+++++ K QEA LL
Sbjct: 2389 ELATQEKVTLVQTLEIQRQQSDHDAERL--REAIAELEREKE---KLQQEAK------LL 2437
Query: 410 QVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEIL-QTYLKSKES 468
Q L+ E + + +Q+ Q L++ + E +Q E + Q K ++
Sbjct: 2438 Q-----LKSEEMQTVQQEQ-----LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2487
Query: 469 VTDAILQTDQILTEKEKE---IEVE----CVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
D + + Q+ E++++ +E E E A+ EE + Q+ +++ E+
Sbjct: 2488 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2547
Query: 522 YQEHVKQLTEKMER--ERAQLLEEQEKTLTSKLQE 554
++ + L E+ +R E+ QLLEEQ + + +E
Sbjct: 2548 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2582
Score = 38.1 bits (87), Expect = 0.023
Identities = 33/122 (27%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 463 LKSKESVTDAILQTDQILTEKEKEI-EVECVKAESAQASAKMVEEMQIKYQQMMEEKE-- 519
L+SKE + Q+ E+E+ E E E Q S EE + + +EE E
Sbjct: 1927 LRSKEQAELEAARQRQLAAEEERRRREAE----ERVQKSLAAEEEAARQRKAALEEVERL 1982
Query: 520 KSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQK 579
K+ E ++L E+ E+E A+ L+ ++ +LQ + + Q + +LQ +Q+ Q
Sbjct: 1983 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Query: 580 TL 581
L
Sbjct: 2043 VL 2044
Score = 36.6 bits (83), Expect = 0.067
Identities = 63/290 (21%), Positives = 120/290 (41%), Gaps = 35/290 (12%)
Query: 321 ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQK 380
E +A A + ++ Q AE L+ + +R+A EV + + K ++
Sbjct: 1440 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAARE 1498
Query: 381 KLAA-----QLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFI 435
K A +L + ++ ++ ++A +R + QV + +A + SK F
Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRAS---FA 1554
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K LE+ EE Q E + + + + ++ E E+E+E +KA
Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-------EAERAREEAERELERWQLKAN 1607
Query: 496 SAQASAKMVEEM-------QIKYQQMMEEKE-------KSYQEHVKQ--LTEKMERERAQ 539
A EE+ Q + ++ EE E K+ ++ V+Q L E+ ++ Q
Sbjct: 1608 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667
Query: 540 LLEEQEKTLTSKLQEQARVLKERCQGESTQ--LQNEIQKLQKTLKKKTKR 587
L E + + QE R+ E QGE + L+ E+ +LQ+ T++
Sbjct: 1668 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1717
Score = 35.8 bits (81), Expect = 0.11
Identities = 36/153 (23%), Positives = 73/153 (47%), Gaps = 16/153 (10%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++ ++L+++ EE ++ EE + K S+ + + Q Q E EI+ + +AE
Sbjct: 1356 REAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAE 1409
Query: 496 SAQASAKMVEE--MQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQ 553
+A+ S +EE ++ Q E+++ E Q R RA+ E Q++ + Q
Sbjct: 1410 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL----RARAEEAEAQKR----QAQ 1461
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKKTK 586
E+A L+ + Q ES + + +L +K + +
Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494
Score = 35.4 bits (80), Expect = 0.15
Identities = 32/153 (20%), Positives = 70/153 (45%), Gaps = 20/153 (13%)
Query: 447 EEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEE 506
++P+ +E ++Q Y+ + ++ T Q + + + +M EE
Sbjct: 1269 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR-------------RMEEE 1315
Query: 507 MQIKYQQMMEEKEKSYQ-----EHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKE 561
++ QQ EE+E+ + E +QL E + +AQ E + K L ++QE+ V +E
Sbjct: 1316 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREAKELQQRMQEEV-VRRE 1373
Query: 562 RCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLK 594
++ Q + IQ+ + L++ ++ + K +
Sbjct: 1374 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1406
Score = 33.5 bits (75), Expect = 0.57
Identities = 38/151 (25%), Positives = 65/151 (43%), Gaps = 18/151 (11%)
Query: 450 RKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK--AESAQASAKMVEEM 507
R+ +AE +L L + T L+T+ + KEKE E E ++ AE + +EE
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATR--LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1851
Query: 508 QIKYQQMMEEK-------EKSYQEHVKQLTEKMERERAQLLEE-------QEKTLTSKLQ 553
+++ +EE+ S E K L E R+R Q+ EE EK K +
Sbjct: 1852 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1911
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKK 584
+ + + R E T E +L+ +++
Sbjct: 1912 LELELGRIRSNAEDTLRSKEQAELEAARQRQ 1942
Score = 33.1 bits (74), Expect = 0.74
Identities = 35/143 (24%), Positives = 63/143 (44%), Gaps = 28/143 (19%)
Query: 474 LQTDQILTEKEKEIEVECVKAESAQASAKMVE------EMQIKYQQMMEEKEKSYQE--H 525
L D + ++ E E+ +KA +A+A E ++ + + KE++ E
Sbjct: 1880 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1939
Query: 526 VKQLTEKMERERAQLLEEQEKTLTSKLQ-------------------EQARVLKERCQGE 566
+QL + ER R + E +K+L ++ + E+AR L+ER + E
Sbjct: 1940 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 1999
Query: 567 ST-QLQNEIQKLQKTLKKKTKRY 588
S QLQ + QK L+ + K +
Sbjct: 2000 SARQLQLAQEAAQKRLQAEEKAH 2022
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 51.2 bits (121), Expect = 3e-06
Identities = 72/318 (22%), Positives = 137/318 (43%), Gaps = 33/318 (10%)
Query: 292 ESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQEL 351
E VL + + E A A Q E AA + +++ Q + A+ +
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2268
Query: 352 LDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQV 411
+EA + + + + L QK+ A +K F +Q R A ++
Sbjct: 2269 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL-----RQKAQVEQ 2323
Query: 412 IFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTY--------- 462
+ L +++ + K L ++LQ L+ + E R+ Q EE L +
Sbjct: 2324 ELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2379
Query: 463 LKSK-ESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
LK++ E+ A++ D+ T++ + E E +K + +A+ V + + + E++ +
Sbjct: 2380 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2439
Query: 522 YQEHV--KQLTEKME--------RERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQ 571
Q + K L EKM+ + A+LL++Q++ QEQAR L+E + + QL
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQEDKEQMAQQLA 2495
Query: 572 NEIQKLQKTLKKKTKRYM 589
E Q Q+TL+ + +R +
Sbjct: 2496 EETQGFQRTLEAERQRQL 2513
Score = 47.0 bits (110), Expect = 5e-05
Identities = 59/315 (18%), Positives = 128/315 (40%), Gaps = 44/315 (13%)
Query: 311 ENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSE------REATE 364
EN L L +N+ + A +Q+ ++ + QE L +++E R E
Sbjct: 2387 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446
Query: 365 VYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKA-- 422
+K + V + K A+L +++ + ++ + + Q L EE +
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ----QLAEETQGFQ 2502
Query: 423 -GIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILT 481
+ ++ + + L+ + E R +AEE Q + K E + + + +T+
Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2562
Query: 482 EK--------------------------EKEIEVECVKAESAQASAKMVEEMQIKYQQMM 515
EK E E E E ++ E+ K E ++ +Q++
Sbjct: 2563 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2622
Query: 516 EEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ---ARVLKERCQGESTQLQN 572
+E + Q + + ++RER +E+++ L Q++ A+ L+E Q + Q++
Sbjct: 2623 QETQALQQSFLSEKDSLLQRER--FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 573 EIQKLQKTLKKKTKR 587
E Q+L ++++ +R
Sbjct: 2681 ERQRLVASMEEARRR 2695
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/149 (22%), Positives = 79/149 (53%), Gaps = 11/149 (7%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++L++ + E K Q ++LQ LKS+E T +Q +Q+L E + + + +
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQT---VQQEQLLQETQALQQSFLSEKD 2637
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
S + +E+ + K +Q+ +++ Q QL E+ +R++ Q+ +E+++ + S E+
Sbjct: 2638 SLLQRERFIEQEKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVAS--MEE 2691
Query: 556 ARVLKERCQGESTQLQNEIQKLQKTLKKK 584
AR + + + Q E+Q+L++ +++
Sbjct: 2692 ARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2720
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/153 (25%), Positives = 73/153 (47%), Gaps = 19/153 (12%)
Query: 436 QKLQDLEK--KYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK 493
+KLQ K + E + +Q E++LQ +++ + L L ++E+ IE E K
Sbjct: 2597 EKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQEKAK 2652
Query: 494 AESA----QASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLT 549
E A A+ + E Q + QQ ME++ + +L ME R + E +E
Sbjct: 2653 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGV-- 2703
Query: 550 SKLQEQARVLKERCQGESTQLQNEIQKLQKTLK 582
+ QE+ + L+++ + + L E Q+L++ L+
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2736
Score = 38.5 bits (88), Expect = 0.018
Identities = 48/215 (22%), Positives = 98/215 (45%), Gaps = 31/215 (14%)
Query: 350 ELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALL 409
EL +V+ + E+ + S D + L ++ A+L+++++ K QEA LL
Sbjct: 2558 ELATQEKVTLVQTLEIQRQQSDHDAERL--REAIAELEREKE---KLQQEAK------LL 2606
Query: 410 QVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEIL-QTYLKSKES 468
Q L+ E + + +Q+ Q L++ + E +Q E + Q K ++
Sbjct: 2607 Q-----LKSEEMQTVQQEQ-----LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2656
Query: 469 VTDAILQTDQILTEKEKE---IEVE----CVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
D + + Q+ E++++ +E E E A+ EE + Q+ +++ E+
Sbjct: 2657 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2716
Query: 522 YQEHVKQLTEKMER--ERAQLLEEQEKTLTSKLQE 554
++ + L E+ +R E+ QLLEEQ + + +E
Sbjct: 2717 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2751
Score = 38.1 bits (87), Expect = 0.023
Identities = 33/122 (27%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 463 LKSKESVTDAILQTDQILTEKEKEI-EVECVKAESAQASAKMVEEMQIKYQQMMEEKE-- 519
L+SKE + Q+ E+E+ E E E Q S EE + + +EE E
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEERRRREAE----ERVQKSLAAEEEAARQRKAALEEVERL 2151
Query: 520 KSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQK 579
K+ E ++L E+ E+E A+ L+ ++ +LQ + + Q + +LQ +Q+ Q
Sbjct: 2152 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Query: 580 TL 581
L
Sbjct: 2212 VL 2213
Score = 36.6 bits (83), Expect = 0.067
Identities = 63/290 (21%), Positives = 120/290 (41%), Gaps = 35/290 (12%)
Query: 321 ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQK 380
E +A A + ++ Q AE L+ + +R+A EV + + K ++
Sbjct: 1609 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAARE 1667
Query: 381 KLAA-----QLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFI 435
K A +L + ++ ++ ++A +R + QV + +A + SK F
Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRAS---FA 1723
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K LE+ EE Q E + + + + ++ E E+E+E +KA
Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-------EAERAREEAERELERWQLKAN 1776
Query: 496 SAQASAKMVEEM-------QIKYQQMMEEKE-------KSYQEHVKQ--LTEKMERERAQ 539
A EE+ Q + ++ EE E K+ ++ V+Q L E+ ++ Q
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836
Query: 540 LLEEQEKTLTSKLQEQARVLKERCQGESTQ--LQNEIQKLQKTLKKKTKR 587
L E + + QE R+ E QGE + L+ E+ +LQ+ T++
Sbjct: 1837 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886
Score = 35.8 bits (81), Expect = 0.11
Identities = 36/153 (23%), Positives = 73/153 (47%), Gaps = 16/153 (10%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++ ++L+++ EE ++ EE + K S+ + + Q Q E EI+ + +AE
Sbjct: 1525 REAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAE 1578
Query: 496 SAQASAKMVEE--MQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQ 553
+A+ S +EE ++ Q E+++ E Q R RA+ E Q++ + Q
Sbjct: 1579 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL----RARAEEAEAQKR----QAQ 1630
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKKTK 586
E+A L+ + Q ES + + +L +K + +
Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663
Score = 35.4 bits (80), Expect = 0.15
Identities = 32/153 (20%), Positives = 70/153 (45%), Gaps = 20/153 (13%)
Query: 447 EEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEE 506
++P+ +E ++Q Y+ + ++ T Q + + + +M EE
Sbjct: 1438 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR-------------RMEEE 1484
Query: 507 MQIKYQQMMEEKEKSYQ-----EHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKE 561
++ QQ EE+E+ + E +QL E + +AQ E + K L ++QE+ V +E
Sbjct: 1485 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREAKELQQRMQEEV-VRRE 1542
Query: 562 RCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLK 594
++ Q + IQ+ + L++ ++ + K +
Sbjct: 1543 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575
Score = 33.5 bits (75), Expect = 0.57
Identities = 38/151 (25%), Positives = 65/151 (43%), Gaps = 18/151 (11%)
Query: 450 RKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK--AESAQASAKMVEEM 507
R+ +AE +L L + T L+T+ + KEKE E E ++ AE + +EE
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATR--LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 2020
Query: 508 QIKYQQMMEEK-------EKSYQEHVKQLTEKMERERAQLLEE-------QEKTLTSKLQ 553
+++ +EE+ S E K L E R+R Q+ EE EK K +
Sbjct: 2021 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 2080
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKK 584
+ + + R E T E +L+ +++
Sbjct: 2081 LELELGRIRSNAEDTLRSKEQAELEAARQRQ 2111
Score = 33.1 bits (74), Expect = 0.74
Identities = 35/143 (24%), Positives = 63/143 (44%), Gaps = 28/143 (19%)
Query: 474 LQTDQILTEKEKEIEVECVKAESAQASAKMVE------EMQIKYQQMMEEKEKSYQE--H 525
L D + ++ E E+ +KA +A+A E ++ + + KE++ E
Sbjct: 2049 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 2108
Query: 526 VKQLTEKMERERAQLLEEQEKTLTSKLQ-------------------EQARVLKERCQGE 566
+QL + ER R + E +K+L ++ + E+AR L+ER + E
Sbjct: 2109 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2168
Query: 567 ST-QLQNEIQKLQKTLKKKTKRY 588
S QLQ + QK L+ + K +
Sbjct: 2169 SARQLQLAQEAAQKRLQAEEKAH 2191
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 51.2 bits (121), Expect = 3e-06
Identities = 72/318 (22%), Positives = 137/318 (43%), Gaps = 33/318 (10%)
Query: 292 ESLVLTYINAISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQEL 351
E VL + + E A A Q E AA + +++ Q + A+ +
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2109
Query: 352 LDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQV 411
+EA + + + + L QK+ A +K F +Q R A ++
Sbjct: 2110 QAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL-----RQKAQVEQ 2164
Query: 412 IFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTY--------- 462
+ L +++ + K L ++LQ L+ + E R+ Q EE L +
Sbjct: 2165 ELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220
Query: 463 LKSK-ESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
LK++ E+ A++ D+ T++ + E E +K + +A+ V + + + E++ +
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280
Query: 522 YQEHV--KQLTEKME--------RERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQ 571
Q + K L EKM+ + A+LL++Q++ QEQAR L+E + + QL
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA----QEQARRLQEDKEQMAQQLA 2336
Query: 572 NEIQKLQKTLKKKTKRYM 589
E Q Q+TL+ + +R +
Sbjct: 2337 EETQGFQRTLEAERQRQL 2354
Score = 47.0 bits (110), Expect = 5e-05
Identities = 59/315 (18%), Positives = 128/315 (40%), Gaps = 44/315 (13%)
Query: 311 ENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSE------REATE 364
EN L L +N+ + A +Q+ ++ + QE L +++E R E
Sbjct: 2228 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287
Query: 365 VYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKA-- 422
+K + V + K A+L +++ + ++ + + Q L EE +
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ----QLAEETQGFQ 2343
Query: 423 -GIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILT 481
+ ++ + + L+ + E R +AEE Q + K E + + + +T+
Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQ 2403
Query: 482 EK--------------------------EKEIEVECVKAESAQASAKMVEEMQIKYQQMM 515
EK E E E E ++ E+ K E ++ +Q++
Sbjct: 2404 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2463
Query: 516 EEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ---ARVLKERCQGESTQLQN 572
+E + Q + + ++RER +E+++ L Q++ A+ L+E Q + Q++
Sbjct: 2464 QETQALQQSFLSEKDSLLQRER--FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 573 EIQKLQKTLKKKTKR 587
E Q+L ++++ +R
Sbjct: 2522 ERQRLVASMEEARRR 2536
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/149 (22%), Positives = 79/149 (53%), Gaps = 11/149 (7%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++L++ + E K Q ++LQ LKS+E T +Q +Q+L E + + + +
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQT---VQQEQLLQETQALQQSFLSEKD 2478
Query: 496 SAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQ 555
S + +E+ + K +Q+ +++ Q QL E+ +R++ Q+ +E+++ + S E+
Sbjct: 2479 SLLQRERFIEQEKAKLEQLFQDEVAKAQ----QLREEQQRQQQQMEQERQRLVAS--MEE 2532
Query: 556 ARVLKERCQGESTQLQNEIQKLQKTLKKK 584
AR + + + Q E+Q+L++ +++
Sbjct: 2533 ARRRQHEAEEGVRRKQEELQQLEQQRRQQ 2561
Score = 40.4 bits (93), Expect = 0.005
Identities = 39/153 (25%), Positives = 73/153 (47%), Gaps = 19/153 (12%)
Query: 436 QKLQDLEK--KYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK 493
+KLQ K + E + +Q E++LQ +++ + L L ++E+ IE E K
Sbjct: 2438 EKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQEKAK 2493
Query: 494 AESA----QASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLT 549
E A A+ + E Q + QQ ME++ + +L ME R + E +E
Sbjct: 2494 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ-------RLVASMEEARRRQHEAEEGV-- 2544
Query: 550 SKLQEQARVLKERCQGESTQLQNEIQKLQKTLK 582
+ QE+ + L+++ + + L E Q+L++ L+
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQ 2577
Score = 38.5 bits (88), Expect = 0.018
Identities = 48/215 (22%), Positives = 98/215 (45%), Gaps = 31/215 (14%)
Query: 350 ELLDLHRVSEREATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALL 409
EL +V+ + E+ + S D + L ++ A+L+++++ K QEA LL
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERL--REAIAELEREKE---KLQQEAK------LL 2447
Query: 410 QVIFSPLEEEVKAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEIL-QTYLKSKES 468
Q L+ E + + +Q+ Q L++ + E +Q E + Q K ++
Sbjct: 2448 Q-----LKSEEMQTVQQEQ-----LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2497
Query: 469 VTDAILQTDQILTEKEKE---IEVE----CVKAESAQASAKMVEEMQIKYQQMMEEKEKS 521
D + + Q+ E++++ +E E E A+ EE + Q+ +++ E+
Sbjct: 2498 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2557
Query: 522 YQEHVKQLTEKMER--ERAQLLEEQEKTLTSKLQE 554
++ + L E+ +R E+ QLLEEQ + + +E
Sbjct: 2558 RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2592
Score = 38.1 bits (87), Expect = 0.023
Identities = 33/122 (27%), Positives = 57/122 (46%), Gaps = 7/122 (5%)
Query: 463 LKSKESVTDAILQTDQILTEKEKEI-EVECVKAESAQASAKMVEEMQIKYQQMMEEKE-- 519
L+SKE + Q+ E+E+ E E E Q S EE + + +EE E
Sbjct: 1937 LRSKEQAELEAARQRQLAAEEERRRREAE----ERVQKSLAAEEEAARQRKAALEEVERL 1992
Query: 520 KSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQK 579
K+ E ++L E+ E+E A+ L+ ++ +LQ + + Q + +LQ +Q+ Q
Sbjct: 1993 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Query: 580 TL 581
L
Sbjct: 2053 VL 2054
Score = 36.6 bits (83), Expect = 0.067
Identities = 63/290 (21%), Positives = 120/290 (41%), Gaps = 35/290 (12%)
Query: 321 ENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSEREATEVYMKNSFKDVDHLFQK 380
E +A A + ++ Q AE L+ + +R+A EV + + K ++
Sbjct: 1450 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAARE 1508
Query: 381 KLAA-----QLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEVKAGIYSKPGGYCLFI 435
K A +L + ++ ++ ++A +R + QV + +A + SK F
Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERARQV-QVALETAQRSAEAELQSKRAS---FA 1564
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
+K LE+ EE Q E + + + + ++ E E+E+E +KA
Sbjct: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQQA-------EAERAREEAERELERWQLKAN 1617
Query: 496 SAQASAKMVEEM-------QIKYQQMMEEKE-------KSYQEHVKQ--LTEKMERERAQ 539
A EE+ Q + ++ EE E K+ ++ V+Q L E+ ++ Q
Sbjct: 1618 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677
Query: 540 LLEEQEKTLTSKLQEQARVLKERCQGESTQ--LQNEIQKLQKTLKKKTKR 587
L E + + QE R+ E QGE + L+ E+ +LQ+ T++
Sbjct: 1678 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727
Score = 35.8 bits (81), Expect = 0.11
Identities = 36/153 (23%), Positives = 73/153 (47%), Gaps = 16/153 (10%)
Query: 436 QKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAE 495
++ ++L+++ EE ++ EE + K S+ + + Q Q E EI+ + +AE
Sbjct: 1366 REAKELQQRMQEEV---VRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAE 1419
Query: 496 SAQASAKMVEE--MQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQLLEEQEKTLTSKLQ 553
+A+ S +EE ++ Q E+++ E Q R RA+ E Q++ + Q
Sbjct: 1420 AAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL----RARAEEAEAQKR----QAQ 1471
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKKTK 586
E+A L+ + Q ES + + +L +K + +
Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504
Score = 35.4 bits (80), Expect = 0.15
Identities = 32/153 (20%), Positives = 70/153 (45%), Gaps = 20/153 (13%)
Query: 447 EEPRKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVKAESAQASAKMVEE 506
++P+ +E ++Q Y+ + ++ T Q + + + +M EE
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR-------------RMEEE 1325
Query: 507 MQIKYQQMMEEKEKSYQ-----EHVKQLTEKMERERAQLLEEQEKTLTSKLQEQARVLKE 561
++ QQ EE+E+ + E +QL E + +AQ E + K L ++QE+ V +E
Sbjct: 1326 ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AEREAKELQQRMQEEV-VRRE 1383
Query: 562 RCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLK 594
++ Q + IQ+ + L++ ++ + K +
Sbjct: 1384 EAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416
Score = 33.5 bits (75), Expect = 0.57
Identities = 38/151 (25%), Positives = 65/151 (43%), Gaps = 18/151 (11%)
Query: 450 RKGIQAEEILQTYLKSKESVTDAILQTDQILTEKEKEIEVECVK--AESAQASAKMVEEM 507
R+ +AE +L L + T L+T+ + KEKE E E ++ AE + +EE
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATR--LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1861
Query: 508 QIKYQQMMEEK-------EKSYQEHVKQLTEKMERERAQLLEE-------QEKTLTSKLQ 553
+++ +EE+ S E K L E R+R Q+ EE EK K +
Sbjct: 1862 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1921
Query: 554 EQARVLKERCQGESTQLQNEIQKLQKTLKKK 584
+ + + R E T E +L+ +++
Sbjct: 1922 LELELGRIRSNAEDTLRSKEQAELEAARQRQ 1952
Score = 33.1 bits (74), Expect = 0.74
Identities = 35/143 (24%), Positives = 63/143 (44%), Gaps = 28/143 (19%)
Query: 474 LQTDQILTEKEKEIEVECVKAESAQASAKMVE------EMQIKYQQMMEEKEKSYQE--H 525
L D + ++ E E+ +KA +A+A E ++ + + KE++ E
Sbjct: 1890 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1949
Query: 526 VKQLTEKMERERAQLLEEQEKTLTSKLQ-------------------EQARVLKERCQGE 566
+QL + ER R + E +K+L ++ + E+AR L+ER + E
Sbjct: 1950 QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2009
Query: 567 ST-QLQNEIQKLQKTLKKKTKRY 588
S QLQ + QK L+ + K +
Sbjct: 2010 SARQLQLAQEAAQKRLQAEEKAH 2032
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,522,908
Number of Sequences: 37866
Number of extensions: 975584
Number of successful extensions: 11016
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 268
Number of HSP's successfully gapped in prelim test: 839
Number of HSP's that attempted gapping in prelim test: 5544
Number of HSP's gapped (non-prelim): 3705
length of query: 595
length of database: 18,247,518
effective HSP length: 108
effective length of query: 487
effective length of database: 14,157,990
effective search space: 6894941130
effective search space used: 6894941130
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.