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Search of human proteins with 11225607
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11225607 interleukin 1 receptor accessory protein-like 2
[Homo sapiens]
(686 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11225607 interleukin 1 receptor accessory protein-like 2 [Hom... 1394 0.0
gi|7657232 interleukin 1 receptor accessory protein-like 1 precu... 870 0.0
gi|4504661 interleukin 1 receptor accessory protein isoform 1 [H... 327 2e-89
gi|4504657 interleukin 18 receptor accessory protein precursor [... 214 3e-55
gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens] 212 8e-55
gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens] 203 4e-52
gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [H... 179 8e-45
gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens] 166 5e-41
gi|19882209 interleukin 1 receptor accessory protein isoform 2 [... 160 5e-39
gi|27894334 interleukin 1 receptor, type II precursor [Homo sapi... 122 1e-27
gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens] 122 1e-27
gi|205277451 single Ig IL-1R-related molecule [Homo sapiens] 96 1e-19
gi|205277449 single Ig IL-1R-related molecule [Homo sapiens] 96 1e-19
gi|205277445 single Ig IL-1R-related molecule [Homo sapiens] 96 1e-19
gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [H... 78 3e-14
gi|118572606 hemicentin 1 [Homo sapiens] 57 6e-08
gi|110349719 titin isoform N2-A [Homo sapiens] 56 1e-07
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 54 6e-07
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 54 6e-07
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 54 6e-07
gi|41350337 toll-like receptor 1 [Homo sapiens] 51 3e-06
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 51 4e-06
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 51 4e-06
gi|75709184 contactin 3 [Homo sapiens] 50 5e-06
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 50 7e-06
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 50 7e-06
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens] 50 7e-06
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 50 7e-06
gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens] 50 7e-06
gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 50 7e-06
>gi|11225607 interleukin 1 receptor accessory protein-like 2 [Homo
sapiens]
Length = 686
Score = 1394 bits (3607), Expect = 0.0
Identities = 686/686 (100%), Positives = 686/686 (100%)
Query: 1 MKPPFLLALVVCSVVSTNLKMVSKRNSVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYI 60
MKPPFLLALVVCSVVSTNLKMVSKRNSVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYI
Sbjct: 1 MKPPFLLALVVCSVVSTNLKMVSKRNSVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYI 60
Query: 61 RTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRN 120
RTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRN
Sbjct: 61 RTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRN 120
Query: 121 STYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWY 180
STYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWY
Sbjct: 121 STYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWY 180
Query: 181 KECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPP 240
KECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPP
Sbjct: 181 KECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPP 240
Query: 241 KPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEI 300
KPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEI
Sbjct: 241 KPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEI 300
Query: 301 RLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIELAGG 360
RLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIELAGG
Sbjct: 301 RLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIELAGG 360
Query: 361 LGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQDTLDCDN 420
LGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQDTLDCDN
Sbjct: 361 LGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQDTLDCDN 420
Query: 421 PEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYIL 480
PEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYIL
Sbjct: 421 PEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYIL 480
Query: 481 RRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLIKWKGSK 540
RRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLIKWKGSK
Sbjct: 481 RRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLIKWKGSK 540
Query: 541 SSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQ 600
SSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQ
Sbjct: 541 SSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQ 600
Query: 601 ADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVPSLGNHHTYCNLPLTLLNGQLPLNNTLK 660
ADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVPSLGNHHTYCNLPLTLLNGQLPLNNTLK
Sbjct: 601 ADLPEFHPSDSMQIRHCCRGYKHEIPATTLPVPSLGNHHTYCNLPLTLLNGQLPLNNTLK 660
Query: 661 DTQEFHRNSSLLPLSSKELSFTSDIW 686
DTQEFHRNSSLLPLSSKELSFTSDIW
Sbjct: 661 DTQEFHRNSSLLPLSSKELSFTSDIW 686
>gi|7657232 interleukin 1 receptor accessory protein-like 1
precursor [Homo sapiens]
Length = 696
Score = 870 bits (2248), Expect = 0.0
Identities = 426/696 (61%), Positives = 542/696 (77%), Gaps = 10/696 (1%)
Query: 1 MKPPFLLALVVCSVVSTNLKMVSKRNSVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYI 60
MK P +++ + + +LK+V+KR S DGC DWS+D+K Y L GEPVR+KCALFY YI
Sbjct: 1 MKAPIPHLILLYATFTQSLKVVTKRGSADGCTDWSIDIKKYQVLVGEPVRIKCALFYGYI 60
Query: 61 RTNYSTAQSTGLRLMWYKNKG--DLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVL 118
RTNYS AQS GL LMWYK+ G D EEPI F RMSKEEDSIWF QDSG Y CV+
Sbjct: 61 RTNYSLAQSAGLSLMWYKSSGPGDFEEPIAFDGSRMSKEEDSIWFRPTLLQDSGLYACVI 120
Query: 119 RNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVV 178
RNSTYCMKVS+SLTV EN++GLCYNS+++Y EK+E++K KEISC D++DF +EP+++
Sbjct: 121 RNSTYCMKVSISLTVGENDTGLCYNSKMKYFEKAELSKSKEISCRDIEDFLLPTREPEIL 180
Query: 179 WYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDK 238
WYKEC+ K WR I+ K + LLI+EV+E+D GNYTCELKY G +VRRTTEL VTA LTDK
Sbjct: 181 WYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKYGGFVVRRTTELTVTAPLTDK 240
Query: 239 PPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEEL-AGHIRE 297
PPK L+PME++ ++ + QLG N+ C+AFFG+SG+ P+IYWMKGEKFIE+L + E
Sbjct: 241 PPKLLYPMESKLTIQETQLGDSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWE 300
Query: 298 GEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIEL 357
+IR+LKEHLGE+EV ++LI DSV E DL NY+C+VEN NGR+HASVLL K++L+Y +EL
Sbjct: 301 SDIRILKEHLGEQEVSISLIVDSVEEGDLGNYSCYVENGNGRRHASVLLHKRELMYTVEL 360
Query: 358 AGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQDTLD 417
AGGLGAI LLLV LV IYKCY IE+MLFYR HFGA+E + DNK+YDAYLSYTKVD D +
Sbjct: 361 AGGLGAILLLLVCLVTIYKCYKIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVDPDQWN 420
Query: 418 CDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVLTPD 477
+ EEE+FALE+LPD+LEKHYGYKLFIP+RDLIP+GTY+ED+ R V+QS+RLIIV+TP+
Sbjct: 421 QETGEEERFALEILPDMLEKHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPN 480
Query: 478 YILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLIKWK 537
Y++RRGWSIFELE+RL NMLV+GEIKVILIEC+EL+G +N QEVE+LK +IKLL++IKW
Sbjct: 481 YVVRRGWSIFELETRLRNMLVTGEIKVILIECSELRGIMNYQEVEALKHTIKLLTVIKWH 540
Query: 538 GSKSSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGLFGELQPIPSIAM-TSTSATL 596
G K +KLNSKFWK L YEMP K+ E + LD +EQG FGELQ + +I+M +TS L
Sbjct: 541 GPKCNKLNSKFWKRLQYEMPFKRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTAL 600
Query: 597 VSSQADL-PEFHPSDSMQIR--HCCRGYKHEIPAT-TLPVPSLGNHHTYCNLPLTLLNGQ 652
++ DL FH + Q+R H R Y++++P T TLP+ S+GN HTYCN+P+TL+NGQ
Sbjct: 601 ATAHPDLRSTFHNTYHSQMRQKHYYRSYEYDVPPTGTLPLTSIGNQHTYCNIPMTLINGQ 660
Query: 653 LPLNNTLKD--TQEFHRNSSLLPLSSKELSFTSDIW 686
P + ++ E H NS++LPL +E S +S IW
Sbjct: 661 RPQTKSSREQNPDEAHTNSAILPLLPRETSISSVIW 696
>gi|4504661 interleukin 1 receptor accessory protein isoform 1 [Homo
sapiens]
Length = 570
Score = 327 bits (838), Expect = 2e-89
Identities = 209/587 (35%), Positives = 311/587 (52%), Gaps = 41/587 (6%)
Query: 7 LALVVCSVVSTNLKMVSKRNSVDGCIDWSVD-LKTYMALAGEPVRVKCALFYSYIRTNYS 65
+ L+ C VVS + + ++ + C DW +D ++ EP R+KC LF +++ NYS
Sbjct: 1 MTLLWC-VVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYS 59
Query: 66 TAQSTGLRLMWY--KNKGDLEEPIIFS--EVRMSKEEDSIWFHSAEAQDSGFYTCVLRNS 121
TA S GL L+WY + DLEEPI F E R+SKE+D +WF D+G YTC+LRN+
Sbjct: 60 TAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNT 119
Query: 122 TYCMKVSMSLTVAENESGLCYNSRIR------YLEKSEVTKRKEISCPDMDDFKKSDQEP 175
TYC KV+ L V + +S C+NS ++ Y+E + I+CP++D + S +P
Sbjct: 120 TYCSKVAFPLEVVQKDS--CFNSPMKLPVHKLYIEYGI----QRITCPNVDGYFPSSVKP 173
Query: 176 DVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKY--EGKLVRRTTELKVTA 233
+ WY C + +I +G L + GNYTC + Y G+ T L V
Sbjct: 174 TITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKV 233
Query: 234 LLTDKPP-KPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELA 292
+ + K P+ N V + + G+ L IPC +F F +S ++W K +++
Sbjct: 234 VGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDIT 293
Query: 293 GHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGR--KHASVLLRKKD 350
+ E E ++ I E +Y CH + G K A V +
Sbjct: 294 IDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPA 353
Query: 351 LIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTK 410
Y +ELA G GA LL+V+L+V+Y Y +E++LFYR HFG DET D KEYD Y+SY +
Sbjct: 354 PRYTVELACGFGATVLLVVILIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYAR 413
Query: 411 VDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRL 470
N EEE+F L L VLE +GYKL I +RD +P G ++ ++++SRRL
Sbjct: 414 ---------NAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRL 464
Query: 471 IIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKL 530
++VL+P+Y+L+ ++ EL++ L NM G I VIL++ +K +V+ LKR+ +
Sbjct: 465 LVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKE----TKVKELKRAKTV 520
Query: 531 LSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSAEQGL 577
L++IKWKG KS +FWK L MP+KK PR S EQGL
Sbjct: 521 LTVIKWKGEKSKYPQGRFWKQLQVAMPVKKS---PRRS--SSDEQGL 562
>gi|4504657 interleukin 18 receptor accessory protein precursor
[Homo sapiens]
Length = 599
Score = 214 bits (544), Expect = 3e-55
Identities = 154/506 (30%), Positives = 255/506 (50%), Gaps = 39/506 (7%)
Query: 74 LMWYK--NKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTC--VLRNSTYCMK--V 127
+ WY+ + GD E I S + +++ ++ F + +SG Y C + S Y + V
Sbjct: 82 VQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCV 141
Query: 128 SMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKM 187
M L V + C S + + + ISCP + + Q P V WYK K
Sbjct: 142 KMILEVKPQTNASCEYSA-SHKQDLLLGSTGSISCPSLS-CQSDAQSPAVTWYKNGK--- 196
Query: 188 WRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKL----VRRTTELKVTALLTDKPPKPL 243
+ +++ N +++ EV + G Y C+ + VR +++ T P L
Sbjct: 197 --LLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDIL 254
Query: 244 FPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLL 303
P+E+ ++V+LGKPL I CKA FGF P+I W + +L + E + +
Sbjct: 255 DPVED---TLEVELGKPLTISCKARFGFERVFNPVIKWYIKDS---DLEWEVSVPEAKSI 308
Query: 304 KEHLGEKEVELALIFDSVVEADLAN-YTCHVENRNGRKHASVLLR-KKDLIYKIELAGGL 361
K L ++ +E +I + V + DL + C V+N G SV L+ K+ ++ L G +
Sbjct: 309 KSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTI 368
Query: 362 GAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQDTLDCDNP 421
G + +L ++Y+ + IE++L YR + D+T D K++DA++SY K + +
Sbjct: 369 GTLVAVLAASALLYRHW-IEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSS 427
Query: 422 -EEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYIL 480
EE AL + PDVLE YGY L + ERD+ P G Y ED+ +++SRR I +L+P+Y+
Sbjct: 428 LSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYV- 486
Query: 481 RRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESL----KRSIKLLSLIKW 536
G SIFEL++ ++ L +K+ILI+ QE ESL K+++++L + W
Sbjct: 487 -NGPSIFELQAAVNLALDDQTLKLILIKFCYF------QEPESLPHLVKKALRVLPTVTW 539
Query: 537 KGSKSSKLNSKFWKHLVYEMPIKKKE 562
+G KS NS+FW + Y MP+K +
Sbjct: 540 RGLKSVPPNSRFWAKMRYHMPVKNSQ 565
>gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens]
Length = 569
Score = 212 bits (540), Expect = 8e-55
Identities = 153/521 (29%), Positives = 257/521 (49%), Gaps = 41/521 (7%)
Query: 74 LMWYKNKGDLEEPIIFSEV-RMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLT 132
+ WYK+ D + P+ + R+ + ++ +WF A+ +DSG Y CV+RNS+YC+++ +S
Sbjct: 55 ITWYKD--DSKTPVSTEQASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIKISAK 112
Query: 133 VAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQE-PDVVWYKECKPKMWRSI 191
ENE LCYN++ + +K V + CP M+ FK + E P + WYK+CKP + +I
Sbjct: 113 FVENEPNLCYNAQAIFKQKLPVAGDGGLVCPYMEFFKNENNELPKLQWYKDCKPLLLDNI 172
Query: 192 IIQ-KGNALLIQEVQEEDGGNYTCELKYE--GKLVRRTTELKVTALLTDKPPKPLFPMEN 248
+ L++ V E+ GNYTC Y GK T ++ L +KP +P+ +
Sbjct: 173 HFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVI-VSP 231
Query: 249 QPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLG 308
++V LG + + C +G+ + YW I+E + E +
Sbjct: 232 ANETMEVDLGSQIQLICNV----TGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVENPANK 287
Query: 309 EKEVELALIFDSVVEADLAN--YTCHVENRNGRKHASVLLRKKDLIYKIELAGGLGAIFL 366
+ + ++ S +E+ +TC +N +G A + L ++ + G + +
Sbjct: 288 RRSTLITVLNISEIESRFYKHPFTCFAKNTHGIDAAYIQLIYPVTNFQKHMIGICVTLTV 347
Query: 367 LLVLLVVIYKCYNIELMLFYRQ--HFGADETNDDNKEYDAYLSYTKV--DQDTLDCDNPE 422
++V V IYK + I+++L+YR + D K YDAY+ Y K + T DCD
Sbjct: 348 IIVCSVFIYKIFKIDIVLWYRDSCYDFLPIKASDGKTYDAYILYPKTVGEGSTSDCD--- 404
Query: 423 EEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVL---TPDYI 479
F +VLP+VLEK GYKLFI RD +E + V++SRRLII+L T +
Sbjct: 405 --IFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFS 462
Query: 480 LRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLL----SLIK 535
G S E + ++N LV IKV+L+E ++ Q+ E + SIK + I+
Sbjct: 463 WLGGSS--EEQIAMYNALVQDGIKVVLLELEKI------QDYEKMPESIKFIKQKHGAIR 514
Query: 536 WKGSKS---SKLNSKFWKHLVYEMPIKKKEMLPRCHVLDSA 573
W G + ++FWK++ Y MP++++ + +L A
Sbjct: 515 WSGDFTQGPQSAKTRFWKNVRYHMPVQRRSPSSKHQLLSPA 555
>gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]
Length = 541
Score = 203 bits (517), Expect = 4e-52
Identities = 171/536 (31%), Positives = 262/536 (48%), Gaps = 67/536 (12%)
Query: 46 GEPVRVK---CALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIF--SEVRMSKEEDS 100
GEP +K C+L + T S WYK+ G E + S R++ +
Sbjct: 33 GEPFYLKHCSCSLAHEIETTTKS----------WYKSSGSQEHVELNPRSSSRIALHDCV 82
Query: 101 IWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEI 160
+ F E D+G Y ++N T K L V C+ R + EV K +I
Sbjct: 83 LEFWPVELNDTGSYFFQMKNYTQKWK----LNVIRRNKHSCFTERQVTSKIVEVKKFFQI 138
Query: 161 SCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCE--LKY 218
+C ++ YK CK + ++ N + + + ED G Y+C L +
Sbjct: 139 TC---ENSYYQTLVNSTSLYKNCK----KLLLENNKNPTIKKNAEFEDQGYYSCVHFLHH 191
Query: 219 EGKLVRRTTELKVTALLTDKP---PKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGES 275
GKL T +T ++ D+ P L P N + V+LGK + + C A
Sbjct: 192 NGKLFNITKTFNIT-IVEDRSNIVPVLLGPKLNH---VAVELGKNVRLNCSALLN----E 243
Query: 276 GPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADL-ANYTCHVE 334
+IYWM GE+ + H E E+R++ G+ L +++ E++L Y C V
Sbjct: 244 EDVIYWMFGEENGSDPNIH-EEKEMRIMTPE-GKWHASKVLRIENIGESNLNVLYNCTVA 301
Query: 335 NRNGRKHASVLLRKK----DLIYKIELAGGLGAIFLLLVLLVVIYKC--YNIELMLFYRQ 388
+ G S +L +K D+ + G + A+ +L+ ++ ++ C Y ++L+LFYR
Sbjct: 302 STGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRH 361
Query: 389 HFGADETNDDNKEYDAYLSYTKVDQDTLDC--DNPEEEQFALEVLPDVLEKHYGYKLFIP 446
DET D K YDA++SY K +C +N EE FA+E+LP VLEKH+GYKL I
Sbjct: 362 LTRRDETLTDGKTYDAFVSYLK------ECRPENGEEHTFAVEILPRVLEKHFGYKLCIF 415
Query: 447 ERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVIL 506
ERD++P G ++++ +E+SRRLIIVL+ Y+ +ELES LH LV +IK+IL
Sbjct: 416 ERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNE--VRYELESGLHEALVERKIKIIL 473
Query: 507 IECTELKGKVNCQEVESLKRSIKLLS---LIKWKGSKSSKLNSKFWKHLVYEMPIK 559
IE T + + L +S+KLL ++KWK KS NS+FWK+L+Y MP K
Sbjct: 474 IEFTPV------TDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAK 523
>gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [Homo
sapiens]
Length = 556
Score = 179 bits (454), Expect = 8e-45
Identities = 140/479 (29%), Positives = 234/479 (48%), Gaps = 24/479 (5%)
Query: 103 FHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISC 162
F A DSG YTC++R+ T+ ++T+ + +S + Y S K +I C
Sbjct: 74 FLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYC 133
Query: 163 PDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKL 222
P +D + + + W+K C+ K + L+I V ED G+YTC+ +
Sbjct: 134 PTIDLYNWT---APLEWFKNCQALQGSRYRAHK-SFLVIDNVMTEDAGDYTCKFIHNENG 189
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPS---VIDVQLGKPLNIPCKAFFGFSGESGPMI 279
+ + + D+ LFP+ P+ + +V++GK N+ C A FG + +
Sbjct: 190 ANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAV 249
Query: 280 YW-MKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLA-NYTCHVENRN 337
W + G K + I++ E + G +++ L V E DL Y C N +
Sbjct: 250 LWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLH 309
Query: 338 GRKHASVLLRKKDLI--YKIELAGGLGAIFLLLV-LLVVIYKCYNIELMLFYRQHFGADE 394
G + +V L +K+ I + I + ++FL+L+ +LV+I K + IE L +R +
Sbjct: 310 GLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLLWRDIAKPYK 369
Query: 395 TNDDNKEYDAYLSYTKVDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSG 454
T +D K YDAY+ Y + + + D + E F ++LPDVLE GY L I RD++P
Sbjct: 370 TRNDGKLYDAYVVYPRNYKSSTDGAS-RVEHFVHQILPDVLENKCGYTLCIYGRDMLPGE 428
Query: 455 TYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKG 514
+ + + +SRR I +LTP + ++ +E E LH L+ + KVILIE E
Sbjct: 429 DVVTAVETNIRKSRRHIFILTPQITHNKEFA-YEQEVALHCALIQNDAKVILIE-MEALS 486
Query: 515 KVNCQEVESLKRSI----KLLSLIKWKG---SKSSKLNSKFWKHLVYEMPIKKKEMLPR 566
+++ + E+L+ S+ K+ IKW+ + LNSKFWKH+ Y+MP+ K +PR
Sbjct: 487 ELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSK--IPR 543
>gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens]
Length = 575
Score = 166 bits (421), Expect = 5e-41
Identities = 151/567 (26%), Positives = 257/567 (45%), Gaps = 57/567 (10%)
Query: 27 SVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEP 86
+ DGC D + +K + A +P C + S + + WYKN +
Sbjct: 18 TADGCKD--IFMKNEILSASQPFAFNCT---------FPPITSGEVSVTWYKNSSKIPVS 66
Query: 87 IIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENE-----SGLC 141
I R+ ++E I F E DSG Y CV++ C ++ ++LTV E G
Sbjct: 67 KIIQS-RIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGL 125
Query: 142 YNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKP-KMWRSIIIQKGNALL 200
N Y + + K ++C F KS + WYK+C K R +++ LL
Sbjct: 126 PNLSDEYKQILHLGKDDSLTCHL--HFPKSCVLGPIKWYKDCNEIKGERFTVLE--TRLL 181
Query: 201 IQEVQEEDGGNYTCE--LKYEGK----LVRRTTELKVTALLTDKPPKPLFPMENQPSVID 254
+ V ED GNY C+ L + GK L T + A PK ++P + I+
Sbjct: 182 VSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHS---IE 238
Query: 255 VQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEEL---AGHIREGEIRLLKEHLGEKE 311
VQLG L + C + ++ + W +++ + IREG ++ H+ +E
Sbjct: 239 VQLGTTLIVDCNVTD--TKDNTNLRCWRVNNTLVDDYYDESKRIREG----VETHVSFRE 292
Query: 312 VELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIELAGGLGAIFLLLVLL 371
L + + +E + +Y G A ++L+ ++ L GGL A+ + V +
Sbjct: 293 HNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSV 352
Query: 372 VVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQDTLDCDNPEEEQFALEVL 431
V IY + I+++L+YR F + ET D K YDAY+ Y K +++ + L +L
Sbjct: 353 VYIYNIFKIDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKES---QRHAVDALVLNIL 409
Query: 432 PDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIF---- 487
P+VLE+ GYKLFI RD P + V+ RRLI+++ P+ + G+ +
Sbjct: 410 PEVLERQCGYKLFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESL---GFGLLKNLS 466
Query: 488 ELESRLHNMLVSGEIKVILIECTELKG-KVNCQEVESLKRSIKLLSLIKWKG---SKSSK 543
E + +++ L+ +KVILIE +++ V + ++ +K+ I+W G +S
Sbjct: 467 EEQIAVYSALIQDGMKVILIELEKIEDYTVMPESIQYIKQK---HGAIRWHGDFTEQSQC 523
Query: 544 LNSKFWKHLVYEMPIKKKEMLPRCHVL 570
+ +KFWK + Y MP ++ P +L
Sbjct: 524 MKTKFWKTVRYHMPPRRCRPFPPVQLL 550
>gi|19882209 interleukin 1 receptor accessory protein isoform 2
[Homo sapiens]
Length = 356
Score = 160 bits (404), Expect = 5e-39
Identities = 108/357 (30%), Positives = 172/357 (48%), Gaps = 21/357 (5%)
Query: 7 LALVVCSVVSTNLKMVSKRNSVDGCIDWSVD-LKTYMALAGEPVRVKCALFYSYIRTNYS 65
+ L+ C VVS + + ++ + C DW +D ++ EP R+KC LF +++ NYS
Sbjct: 1 MTLLWC-VVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYS 59
Query: 66 TAQSTGLRLMWY--KNKGDLEEPIIFS--EVRMSKEEDSIWFHSAEAQDSGFYTCVLRNS 121
TA S GL L+WY + DLEEPI F E R+SKE+D +WF D+G YTC+LRN+
Sbjct: 60 TAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNT 119
Query: 122 TYCMKVSMSLTVAENESGLCYNSRIR------YLEKSEVTKRKEISCPDMDDFKKSDQEP 175
TYC KV+ L V + +S C+NS ++ Y+E + I+CP++D + S +P
Sbjct: 120 TYCSKVAFPLEVVQKDS--CFNSPMKLPVHKLYIEYG----IQRITCPNVDGYFPSSVKP 173
Query: 176 DVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKY--EGKLVRRTTELKVTA 233
+ WY C + +I +G L + GNYTC + Y G+ T L V
Sbjct: 174 TITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKV 233
Query: 234 LLTDK-PPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELA 292
+ + K P+ N V + + G+ L IPC +F F +S ++W K +++
Sbjct: 234 VGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDIT 293
Query: 293 GHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKK 349
+ E E ++ I E +Y CH + G + +++K
Sbjct: 294 IDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK 350
>gi|27894334 interleukin 1 receptor, type II precursor [Homo
sapiens]
Length = 398
Score = 122 bits (305), Expect = 1e-27
Identities = 96/346 (27%), Positives = 154/346 (44%), Gaps = 36/346 (10%)
Query: 7 LALVVCSVVSTNLKMVSKRNSVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYIRTNYST 66
L ++V V + L+ + + C K L GEPV ++C ++ + S
Sbjct: 4 LYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSP 63
Query: 67 AQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMK 126
+ L W+KN P E RM ++ ++W A +DSG Y C RN++YC K
Sbjct: 64 R----INLTWHKNDSARTVPGE-EETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDK 118
Query: 127 VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPK 186
+S+ L V EN + I Y + ++ + CPD+ +F + + + WYK+
Sbjct: 119 MSIELRVFENTD--AFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKD---- 172
Query: 187 MWRSIIIQKGNA----------LLIQEVQEEDGGNYTCELKY--EGKL--VRRTTELKVT 232
S+++ K N LL+ +V ED G Y C L + EG+ + R+ EL++
Sbjct: 173 ---SLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIK 229
Query: 233 ALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEEL- 291
+ P + P++ I LG L IPCK F G M++W + IE
Sbjct: 230 KKKEETIPVIISPLK----TISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAY 285
Query: 292 -AGHIREGEIRLLKEHLGEKEVELALIFDSVVEADL-ANYTCHVEN 335
G + EG + E+ E +E+ LIFD V DL ++ C V N
Sbjct: 286 PGGRVTEGPRQEYSEN-NENYIEVPLIFDPVTREDLHMDFKCVVHN 330
>gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens]
Length = 398
Score = 122 bits (305), Expect = 1e-27
Identities = 96/346 (27%), Positives = 154/346 (44%), Gaps = 36/346 (10%)
Query: 7 LALVVCSVVSTNLKMVSKRNSVDGCIDWSVDLKTYMALAGEPVRVKCALFYSYIRTNYST 66
L ++V V + L+ + + C K L GEPV ++C ++ + S
Sbjct: 4 LYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSP 63
Query: 67 AQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMK 126
+ L W+KN P E RM ++ ++W A +DSG Y C RN++YC K
Sbjct: 64 R----INLTWHKNDSARTVPGE-EETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDK 118
Query: 127 VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPK 186
+S+ L V EN + I Y + ++ + CPD+ +F + + + WYK+
Sbjct: 119 MSIELRVFENTD--AFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKD---- 172
Query: 187 MWRSIIIQKGNA----------LLIQEVQEEDGGNYTCELKY--EGKL--VRRTTELKVT 232
S+++ K N LL+ +V ED G Y C L + EG+ + R+ EL++
Sbjct: 173 ---SLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIK 229
Query: 233 ALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEEL- 291
+ P + P++ I LG L IPCK F G M++W + IE
Sbjct: 230 KKKEETIPVIISPLK----TISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAY 285
Query: 292 -AGHIREGEIRLLKEHLGEKEVELALIFDSVVEADL-ANYTCHVEN 335
G + EG + E+ E +E+ LIFD V DL ++ C V N
Sbjct: 286 PGGRVTEGPRQEYSEN-NENYIEVPLIFDPVTREDLHMDFKCVVHN 330
>gi|205277451 single Ig IL-1R-related molecule [Homo sapiens]
Length = 410
Score = 95.9 bits (237), Expect = 1e-19
Identities = 91/325 (28%), Positives = 148/325 (45%), Gaps = 22/325 (6%)
Query: 237 DKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGE--SGPMIYWMKGEKFIEELAGH 294
D+ P L P E+Q V+ LG + + C A+ SG S P + W+K + + GH
Sbjct: 6 DRAPDFLSPSEDQ--VLRPALGSSVALNCTAWV-VSGPHCSLPSVQWLK-DGLPLGIGGH 61
Query: 295 IREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYK 354
E +K +L E V L + +TC ++N + +S L++
Sbjct: 62 YSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNIS---FSSFTLQRAGPTSH 118
Query: 355 IELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQD 414
+ + L L+L ++Y + ++L+Y+ +G E ND K YDAY+SY+
Sbjct: 119 VAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEIND-GKLYDAYVSYS----- 172
Query: 415 TLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVL 474
DC PE+ +F +L LE+ GYKLF+ +RDL+P DL + + RRLI+VL
Sbjct: 173 --DC--PEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVL 228
Query: 475 TPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLI 534
+ D L R W L +L + I I + + L++ L++L+
Sbjct: 229 S-DAFLSRAWCSHSFREGLCRLLELTR-RPIFITFEGQRRDPAHPALRLLRQHRHLVTLL 286
Query: 535 KWKGSKSSKLNSKFWKHLVYEMPIK 559
W+ S +S FWK + +P K
Sbjct: 287 LWRPG-SVTPSSDFWKEVQLALPRK 310
>gi|205277449 single Ig IL-1R-related molecule [Homo sapiens]
Length = 410
Score = 95.9 bits (237), Expect = 1e-19
Identities = 91/325 (28%), Positives = 148/325 (45%), Gaps = 22/325 (6%)
Query: 237 DKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGE--SGPMIYWMKGEKFIEELAGH 294
D+ P L P E+Q V+ LG + + C A+ SG S P + W+K + + GH
Sbjct: 6 DRAPDFLSPSEDQ--VLRPALGSSVALNCTAWV-VSGPHCSLPSVQWLK-DGLPLGIGGH 61
Query: 295 IREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYK 354
E +K +L E V L + +TC ++N + +S L++
Sbjct: 62 YSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNIS---FSSFTLQRAGPTSH 118
Query: 355 IELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQD 414
+ + L L+L ++Y + ++L+Y+ +G E ND K YDAY+SY+
Sbjct: 119 VAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEIND-GKLYDAYVSYS----- 172
Query: 415 TLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVL 474
DC PE+ +F +L LE+ GYKLF+ +RDL+P DL + + RRLI+VL
Sbjct: 173 --DC--PEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVL 228
Query: 475 TPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLI 534
+ D L R W L +L + I I + + L++ L++L+
Sbjct: 229 S-DAFLSRAWCSHSFREGLCRLLELTR-RPIFITFEGQRRDPAHPALRLLRQHRHLVTLL 286
Query: 535 KWKGSKSSKLNSKFWKHLVYEMPIK 559
W+ S +S FWK + +P K
Sbjct: 287 LWRPG-SVTPSSDFWKEVQLALPRK 310
>gi|205277445 single Ig IL-1R-related molecule [Homo sapiens]
Length = 410
Score = 95.9 bits (237), Expect = 1e-19
Identities = 91/325 (28%), Positives = 148/325 (45%), Gaps = 22/325 (6%)
Query: 237 DKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGE--SGPMIYWMKGEKFIEELAGH 294
D+ P L P E+Q V+ LG + + C A+ SG S P + W+K + + GH
Sbjct: 6 DRAPDFLSPSEDQ--VLRPALGSSVALNCTAWV-VSGPHCSLPSVQWLK-DGLPLGIGGH 61
Query: 295 IREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYK 354
E +K +L E V L + +TC ++N + +S L++
Sbjct: 62 YSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNIS---FSSFTLQRAGPTSH 118
Query: 355 IELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHFGADETNDDNKEYDAYLSYTKVDQD 414
+ + L L+L ++Y + ++L+Y+ +G E ND K YDAY+SY+
Sbjct: 119 VAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEIND-GKLYDAYVSYS----- 172
Query: 415 TLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYMEDLTRYVEQSRRLIIVL 474
DC PE+ +F +L LE+ GYKLF+ +RDL+P DL + + RRLI+VL
Sbjct: 173 --DC--PEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVL 228
Query: 475 TPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNCQEVESLKRSIKLLSLI 534
+ D L R W L +L + I I + + L++ L++L+
Sbjct: 229 S-DAFLSRAWCSHSFREGLCRLLELTR-RPIFITFEGQRRDPAHPALRLLRQHRHLVTLL 286
Query: 535 KWKGSKSSKLNSKFWKHLVYEMPIK 559
W+ S +S FWK + +P K
Sbjct: 287 LWRPG-SVTPSSDFWKEVQLALPRK 310
>gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [Homo
sapiens]
Length = 328
Score = 77.8 bits (190), Expect = 3e-14
Identities = 63/253 (24%), Positives = 111/253 (43%), Gaps = 9/253 (3%)
Query: 103 FHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISC 162
F A DSG YTC++R+ T+ ++T+ + +S + Y S K +I C
Sbjct: 74 FLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYC 133
Query: 163 PDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKL 222
P +D + + + W+K C+ K + L+I V ED G+YTC+ +
Sbjct: 134 PTIDLY---NWTAPLEWFKNCQALQGSRYRAHK-SFLVIDNVMTEDAGDYTCKFIHNENG 189
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPS---VIDVQLGKPLNIPCKAFFGFSGESGPMI 279
+ + + D+ LFP+ P+ + +V++GK N+ C A FG + +
Sbjct: 190 ANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAV 249
Query: 280 YW-MKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEAD-LANYTCHVENRN 337
W + G K + I++ E + G +++ L V E D L Y C N +
Sbjct: 250 LWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLH 309
Query: 338 GRKHASVLLRKKD 350
G + +V L +K+
Sbjct: 310 GLRRHTVRLSRKN 322
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 57.0 bits (136), Expect = 6e-08
Identities = 75/289 (25%), Positives = 116/289 (40%), Gaps = 52/289 (17%)
Query: 74 LMWYKNKGDLEEPIIFSEVRMSKEED-SIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLT 132
++W K KG+L I S + S D S++ S ++SG Y C N+ K + LT
Sbjct: 1012 VIWSK-KGEL---ISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLT 1067
Query: 133 VAE------NESGLCYNS--RIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECK 184
V ++ GL + I L EVT E+ KS P + W KE +
Sbjct: 1068 VYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV---------KSLPPPIITWAKETQ 1118
Query: 185 ---PKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPK 241
P R + G+ + I E + D G Y C V + +L V PPK
Sbjct: 1119 LISPFSPRHTFLPSGS-MKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV-----PPK 1172
Query: 242 PLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIR 301
++ P + VQ+G+ ++IPC A G P+I W KG + + +GE
Sbjct: 1173 ----IQRGPKHLKVQVGQRVDIPCNA----QGTPLPVITWSKGGSTM------LVDGE-- 1216
Query: 302 LLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKD 350
H+ + L++ D +D YTC N G + L ++
Sbjct: 1217 ---HHVSNPDGTLSI--DQATPSDAGIYTCVATNIAGTDETEITLHVQE 1260
Score = 51.6 bits (122), Expect = 2e-06
Identities = 54/231 (23%), Positives = 87/231 (37%), Gaps = 28/231 (12%)
Query: 67 AQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMK 126
AQ T L ++ + G ++ E +S + ++ A D+G YTCV N +
Sbjct: 1194 AQGTPLPVITWSKGGSTM--LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDE 1251
Query: 127 VSMSLTVAE----NESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKE 182
++L V E + YN+ ++ +R E CP K +P + W
Sbjct: 1252 TEITLHVQEPPTVEDLEPPYNTTF---QERVANQRIEFPCP-----AKGTPKPTIKWLHN 1303
Query: 183 CKPKMWRS---IIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKP 239
+ R I++ G L+I V D G Y C E R LKV
Sbjct: 1304 GRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV------ 1357
Query: 240 PKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEE 290
P+ + Q + + V L + N+ C+ G P+I W K + E
Sbjct: 1358 -PPVIKDKEQVTNVSVLLNQLTNLFCEV----EGTPSPIIMWYKDNVQVTE 1403
Score = 45.4 bits (106), Expect = 2e-04
Identities = 68/303 (22%), Positives = 116/303 (38%), Gaps = 42/303 (13%)
Query: 66 TAQSTGLRL---MWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNST 122
T +++G+ L W+K+ + + + VR+ + +D+G YTCV+RN+
Sbjct: 2407 TCEASGIPLPSITWFKDGWPVS---LSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAA 2463
Query: 123 YCMK--VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWY 180
+ +S+ V + G ++ EK VT E++ + P++ W+
Sbjct: 2464 GEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVT---------GNPVPEITWH 2514
Query: 181 KECKPKMWRSI--IIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDK 238
K+ +P II G L I VQ G YTC R+ L V
Sbjct: 2515 KDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFV----S 2570
Query: 239 PPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREG 298
P + P + V L P ++ C+A+ I W K +E
Sbjct: 2571 PTIAGVGSDGNPEDVTVILNSPTSLVCEAY----SYPPATITWFKDGTPLES------NR 2620
Query: 299 EIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGR--KHASVLLRKKDLIYKIE 356
IR+L G + +++ + E + Y+C N G KH V + +I K +
Sbjct: 2621 NIRILP---GGRTLQIL----NAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGD 2673
Query: 357 LAG 359
L G
Sbjct: 2674 LWG 2676
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/254 (22%), Positives = 94/254 (37%), Gaps = 53/254 (20%)
Query: 98 EDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRY-LEKSEVTK 156
+ +++ +A +D+G Y C+ NS K + +L E + S + L V +
Sbjct: 663 DGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVME 722
Query: 157 RKEISCPDMDDFKKSDQEPDVVWYK---ECKPKMWRSIIIQKGNALLIQEVQEEDGGNYT 213
K P P V W+K E +P + I G L IQE Q+ D G+YT
Sbjct: 723 CKTSGIPP----------PQVKWFKGDLELRPSTFLIIDPLLG-LLKIQETQDLDAGDYT 771
Query: 214 C-ELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFS 272
C + G+ + T D P+F E P+ + +++G + +PC
Sbjct: 772 CVAINEAGRATGKIT--------LDVGSPPVFIQE--PADVSMEIGSNVTLPCYV----Q 817
Query: 273 GESGPMIYWMK-------GEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEAD 325
G P I W + F +R G AL ++ +D
Sbjct: 818 GYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTG----------------ALFILNLWASD 861
Query: 326 LANYTCHVENRNGR 339
Y C EN+ G+
Sbjct: 862 KGTYICEAENQFGK 875
Score = 44.3 bits (103), Expect = 4e-04
Identities = 58/277 (20%), Positives = 103/277 (37%), Gaps = 45/277 (16%)
Query: 74 LMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRN--STYCMKVSMSL 131
+MWYK+ + E V K + A +D+G Y+C N T ++ +
Sbjct: 1392 IMWYKDNVQVTESSTIQTVNNGK---ILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDV 1448
Query: 132 TVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSI 191
V G + + + + +V ++ K PD+ W+K+ KP
Sbjct: 1449 LVPPTIIGTNFPNEVSVVLNRDVALECQV---------KGTPFPDIHWFKDGKPLFLGDP 1499
Query: 192 ---IIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMEN 248
++ +G L ++ + D G Y C + ++ ++K+T + P N
Sbjct: 1500 NVELLDRGQVLHLKNARRNDKGRYQCTVSNAAG--KQAKDIKLTIYIP-----PSIKGGN 1552
Query: 249 QPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFI--EELAGHIREGEIRLLKEH 306
+ I V + + + C+ G P I W K + I A +I +G+ H
Sbjct: 1553 VTTDISVLINSLIKLECET----RGLPMPAITWYKDGQPIMSSSQALYIDKGQYL----H 1604
Query: 307 LGEKEVELALIFDSVVEADLANYTCHVENRNGRKHAS 343
+ +V +D A YTCHV N G S
Sbjct: 1605 IPRAQV-----------SDSATYTCHVANVAGTAEKS 1630
Score = 43.9 bits (102), Expect = 5e-04
Identities = 29/108 (26%), Positives = 46/108 (42%), Gaps = 13/108 (12%)
Query: 191 IIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQP 250
I ++ +L I+ VQ +DGG YTC +TT + V L T +++
Sbjct: 937 ITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPT---------IQHGQ 987
Query: 251 SVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREG 298
++ G P+ +PCKA SG P + W K + I + G
Sbjct: 988 QILSTIEGIPVTLPCKA----SGNPKPSVIWSKKGELISTSSAKFSAG 1031
Score = 42.7 bits (99), Expect = 0.001
Identities = 70/286 (24%), Positives = 108/286 (37%), Gaps = 50/286 (17%)
Query: 66 TAQSTGL---RLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNST 122
T +TG+ + W KN +E EVR+ + ++ DSG YTC+ N
Sbjct: 3172 TCDATGIPPPTIAWLKNHKRIENSDSL-EVRILSGGSKLQIARSQHSDSGNYTCIASNME 3230
Query: 123 YCMK--VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWY 180
+ +S+ V + +G S + L V E+ C P + W
Sbjct: 3231 GKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENV----ELVCN-----ANGIPTPLIQWL 3281
Query: 181 KECKP----KMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLT 236
K+ KP + R + G+ L I D G YTC R L V T
Sbjct: 3282 KDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPT 3341
Query: 237 DKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIR 296
+ K E +++D +NI C+A +G P I W+K + L+ HIR
Sbjct: 3342 IRGNKD--EAEKLMTLVDTS----INIECRA----TGTPPPQINWLKNGLPL-PLSSHIR 3390
Query: 297 ---EGE-IRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNG 338
G+ IR+++ + +D+A YTC NR G
Sbjct: 3391 LLAAGQVIRIVRAQV----------------SDVAVYTCVASNRAG 3420
Score = 42.4 bits (98), Expect = 0.001
Identities = 57/269 (21%), Positives = 93/269 (34%), Gaps = 41/269 (15%)
Query: 74 LMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTV 133
+ WYK+ L + + + D SA+ D+G Y CV NS ++ SL V
Sbjct: 1952 ITWYKDNRLLSGSTSMTFLNRGQIID---IESAQISDAGIYKCVAINSAGATELFYSLQV 2008
Query: 134 AENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRS--- 190
S N+ + + + V E + P + W K+ P S
Sbjct: 2009 HVAPSISGSNNMVAVVVNNPVRLECE---------ARGIPAPSLTWLKDGSPVSSFSNGL 2059
Query: 191 IIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQP 250
++ G L + Q D G YTC +R +L+V PP + +N
Sbjct: 2060 QVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV-----PPNIMGEEQN-- 2112
Query: 251 SVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEK 310
+ V + + + + C++ P + W+K +G L K L
Sbjct: 2113 --VSVLISQAVELLCQS----DAIPPPTLTWLK-------------DGHPLLKKPGLSIS 2153
Query: 311 EVELALIFDSVVEADLANYTCHVENRNGR 339
E L + D YTC N G+
Sbjct: 2154 ENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Score = 42.4 bits (98), Expect = 0.001
Identities = 56/239 (23%), Positives = 96/239 (40%), Gaps = 36/239 (15%)
Query: 105 SAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSR-IRYLEKSEVTKRKEISCP 163
+ + D G Y CV N+ K +L V S + S + + + ++ E+S
Sbjct: 2932 NTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVS-- 2989
Query: 164 DMDDFKKSDQEPDVVWYKECKPKMWRS--IIIQKGNALLIQEVQEEDGGNYTCELKYEGK 221
PD+ W K +P + +I+ G L I + DGG YTC
Sbjct: 2990 -------GFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTC------I 3036
Query: 222 LVRRTTELKVTALLTDKPPKPLFPMENQP-SVIDVQLGKPLNIPCKAFFGFSGESGPMIY 280
+ + E K LT P + +++ SV++V+ G +++ C++ + P+I
Sbjct: 3037 AINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECES----NAVPPPVIT 3092
Query: 281 WMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGR 339
W K + I E + H+ EI + L K+ E+ +D Y C N GR
Sbjct: 3093 WYKNGRMITE-STHV---EILADGQMLHIKKAEV---------SDTGQYVCRAINVAGR 3138
Score = 40.8 bits (94), Expect = 0.004
Identities = 55/242 (22%), Positives = 90/242 (37%), Gaps = 40/242 (16%)
Query: 105 SAEAQDSGFYTCVLRNST--YCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISC 162
+A D G Y C + N+ + +++ + + G + I L S + E
Sbjct: 1514 NARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRG 1573
Query: 163 PDMDDFKKSDQEPDVVWYKECKPKMWRS--IIIQKGNALLIQEVQEEDGGNYTCELKYEG 220
M P + WYK+ +P M S + I KG L I Q D YTC +
Sbjct: 1574 LPM---------PAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVA 1624
Query: 221 KLVRRT--TELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPM 278
++ ++ V ++ PL N+ VI L + CKA +G P+
Sbjct: 1625 GTAEKSFHVDVYVPPMIEGNLATPL----NKQVVI----AHSLTLECKA----AGNPSPI 1672
Query: 279 IYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNG 338
+ W+K ++ IR+ G K++E+ S E D Y C + G
Sbjct: 1673 LTWLKDGVPVK------ANDNIRI---EAGGKKLEIM----SAQEIDRGQYICVATSVAG 1719
Query: 339 RK 340
K
Sbjct: 1720 EK 1721
Score = 40.8 bits (94), Expect = 0.004
Identities = 64/284 (22%), Positives = 104/284 (36%), Gaps = 47/284 (16%)
Query: 68 QSTGL---RLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRN---- 120
+S+G+ L+W K KG VR+ + AE D+ Y+CV N
Sbjct: 2219 ESSGIPPPNLIW-KKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGT 2277
Query: 121 --STYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVV 178
Y ++V + T+ + S + + VT+ K IS ++ + P V
Sbjct: 2278 AKKEYNLQVYIRPTITNSGS---------HPTEIIVTRGKSIS---LECEVQGIPPPTVT 2325
Query: 179 WYKECKP--KMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLT 236
W K+ P K I+ +G+ L ++ + D G Y C + + +L V A
Sbjct: 2326 WMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHA--- 2382
Query: 237 DKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIR 296
P + P I V +++ C+A SG P I W K +
Sbjct: 2383 ---PPSIIGNHRSPENISVVEKNSVSLTCEA----SGIPLPSITWFKDGWPVS------L 2429
Query: 297 EGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRK 340
+R+L G + + L D YTC V N G +
Sbjct: 2430 SNSVRILS---GGRMLRLM----QTTMEDAGQYTCVVRNAAGEE 2466
Score = 40.8 bits (94), Expect = 0.004
Identities = 56/271 (20%), Positives = 95/271 (35%), Gaps = 32/271 (11%)
Query: 74 LMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTV 133
L WYK+ L+ V ++ ++ A+ D+G YTCV N ++ + +
Sbjct: 2706 LSWYKDGQPLKSD---DHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNI 2762
Query: 134 AENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDF---KKSDQEPDVVWYKECKP--KMW 188
S L+ + K++ + + P + WYK+ P
Sbjct: 2763 QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSD 2822
Query: 189 RSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMEN 248
+ +I+ G L I + ED G YTC E +++V PP +
Sbjct: 2823 KVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLV-----PPIIKGANSD 2877
Query: 249 QPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK-GEKFIEELAGHIREGEIRLLKEHL 307
P + V + K I C + SG P W K G+ +E+ H
Sbjct: 2878 LPEEVTVLVNKSALIECLS----SGSPAPRNSWQKDGQPLLED-------------DHHK 2920
Query: 308 GEKEVELALIFDSVVEADLANYTCHVENRNG 338
+ I ++ + D+ Y C EN G
Sbjct: 2921 FLSNGRILQILNTQI-TDIGRYVCVAENTAG 2950
Score = 40.8 bits (94), Expect = 0.004
Identities = 62/272 (22%), Positives = 92/272 (33%), Gaps = 39/272 (14%)
Query: 74 LMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTV 133
+ WYKN + E + V + + + AE D+G Y C N + L V
Sbjct: 3091 ITWYKNGRMITES---THVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNV 3147
Query: 134 AENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECK----PKMWR 189
S R + ++ ++C P + W K K
Sbjct: 3148 YVPPS---IEGPEREVIVETISNPVTLTCD-----ATGIPPPTIAWLKNHKRIENSDSLE 3199
Query: 190 SIIIQKGNALLIQEVQEEDGGNYTC-ELKYEGKLVRRTTELKVTALLTDKPPKPLFPMEN 248
I+ G+ L I Q D GNYTC EGK K L PP
Sbjct: 3200 VRILSGGSKLQIARSQHSDSGNYTCIASNMEGK------AQKYYFLSIQVPPS--VAGAE 3251
Query: 249 QPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLG 308
PS + V LG+ + + C A +G P+I W+K K I GE ++
Sbjct: 3252 IPSDVSVLLGENVELVCNA----NGIPTPLIQWLKDGK-------PIASGETERIRVSAN 3300
Query: 309 EKEVELALIFDSVVEADLANYTCHVENRNGRK 340
+ + + +D YTC N G +
Sbjct: 3301 GSTLNIY----GALTSDTGKYTCVATNPAGEE 3328
Score = 40.0 bits (92), Expect = 0.007
Identities = 53/218 (24%), Positives = 82/218 (37%), Gaps = 33/218 (15%)
Query: 73 RLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLT 132
++ W KN L + S +R+ I A+ D YTCV N +L
Sbjct: 3373 QINWLKNGLPLP---LSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQ 3429
Query: 133 V-----AENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKM 187
V +N G E+ V K S + D P + W ++ +P
Sbjct: 3430 VFAPPNMDNSMGT---------EEITVLKGSSTSMACITD---GTPAPSMAWLRDGQPLG 3477
Query: 188 WRSIIIQKGNALLIQ--EVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFP 245
+ + + +++Q + + ED G YTC E V + LKV +PP
Sbjct: 3478 LDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVL-----EPPHINGS 3532
Query: 246 MENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
E++ I V + PL + C A SG P + WMK
Sbjct: 3533 EEHEE--ISVIVNNPLELTCIA----SGIPAPKMTWMK 3564
Score = 39.3 bits (90), Expect = 0.012
Identities = 48/224 (21%), Positives = 85/224 (37%), Gaps = 37/224 (16%)
Query: 74 LMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTV 133
+MW K+ ++E F + ++ + A+ ++G Y C+ N+ K +TV
Sbjct: 1766 IMWLKDGQLIDERDGFKILLNGRK---LVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 134 ----AENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKP---K 186
SGL ++Y K + C P + W K+ +P
Sbjct: 1823 HVPPTIKSSGLSERVVVKY-------KPVALQC-----IANGIPNPSITWLKDDQPVNTA 1870
Query: 187 MWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPM 246
I G L I + ED G YTC ++ +L V +PP +
Sbjct: 1871 QGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHV-----HEPPS----L 1921
Query: 247 ENQPSVID--VQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFI 288
E+ +++ V + P+ + CKA +G P+I W K + +
Sbjct: 1922 EDAGKMLNETVLVSNPVQLECKA----AGNPVPVITWYKDNRLL 1961
Score = 39.3 bits (90), Expect = 0.012
Identities = 52/214 (24%), Positives = 82/214 (38%), Gaps = 28/214 (13%)
Query: 92 VRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSR----IR 147
V + E + + D+G Y CV N L+V S + N R I
Sbjct: 2339 VEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPS-IIGNHRSPENIS 2397
Query: 148 YLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKP-KMWRSI-IIQKGNALLIQEVQ 205
+EK+ V+ E S + P + W+K+ P + S+ I+ G L + +
Sbjct: 2398 VVEKNSVSLTCEASGIPL---------PSITWFKDGWPVSLSNSVRILSGGRMLRLMQTT 2448
Query: 206 EEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPC 265
ED G YTC ++ R+ L V P EN + V+ + + + C
Sbjct: 2449 MEDAGQYTCVVRNAAGEERKIFGLSVLV-------PPHIVGENTLEDVKVKEKQSVTLTC 2501
Query: 266 KAFFGFSGESGPMIYWMK-GEKFIEELAGHIREG 298
+ +G P I W K G+ E+ A HI G
Sbjct: 2502 EV----TGNPVPEITWHKDGQPLQEDEAHHIISG 2531
Score = 39.3 bits (90), Expect = 0.012
Identities = 54/244 (22%), Positives = 88/244 (36%), Gaps = 35/244 (14%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRK-EISCPD 164
AE +DSG YTC+ N + L V E N + E S + E++C
Sbjct: 3496 AETEDSGKYTCIASNEAGEVSKHFILKVLEPPH---INGSEEHEEISVIVNNPLELTC-- 3550
Query: 165 MDDFKKSDQEPDVVWYKECKPKMWRSII--IQKGNALLIQEVQEEDGGNYTCELKYEGKL 222
P + W K+ +P + + G L I Q ED G YTC L
Sbjct: 3551 ---IASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTC-------L 3600
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWM 282
L P ++P I V + + + CK+ P+I W+
Sbjct: 3601 ASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKS----DAVPPPVITWL 3656
Query: 283 KGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHA 342
+ + ++ +R+L G + +++ ++ D ANYTC N G+
Sbjct: 3657 RNGERLQATP------RVRILS---GGRYLQI----NNADLGDTANYTCVASNIAGKTTR 3703
Query: 343 SVLL 346
+L
Sbjct: 3704 EFIL 3707
Score = 38.9 bits (89), Expect = 0.016
Identities = 55/224 (24%), Positives = 89/224 (39%), Gaps = 34/224 (15%)
Query: 66 TAQSTGL---RLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNST 122
+ ++TG+ +L W N + P F V E + +DSG Y C NS
Sbjct: 4280 SCKATGIPLPKLTWTFNNNII--PAHFDSVNGHSE---LVIERVSKEDSGTYVCTAENSV 4334
Query: 123 YCMKVSMSLTVAENE--SGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWY 180
+K + V E G ++ I L + + ++C K D P + W
Sbjct: 4335 GFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAI-----LNCE-----VKGDPTPTIQWN 4384
Query: 181 KECKPKMWRSIIIQKGN-ALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKP 239
++ I Q GN +L I ED G+YTC E +V R+ L + +
Sbjct: 4385 RKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQS------ 4438
Query: 240 PKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
P+ +E +VI+ G + + C+A +GE P I W +
Sbjct: 4439 -PPIITLEPVETVINA--GGKIILNCQA----TGEPQPTITWSR 4475
Score = 37.7 bits (86), Expect = 0.036
Identities = 48/237 (20%), Positives = 97/237 (40%), Gaps = 35/237 (14%)
Query: 105 SAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPD 164
SA+ D+G YTCV N+ + + L V + + + L +++ E+ C
Sbjct: 2072 SAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVL----ISQAVELLCQS 2127
Query: 165 MDDFKKSDQEPDVVWYKECKPKMWRS--IIIQKGNALLIQEVQEEDGGNYTCELKYEGKL 222
+ P + W K+ P + + I + + L I++ Q +D G YTCE
Sbjct: 2128 -----DAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW- 281
+ + + P ++ + + V G +++ C++ SG P + W
Sbjct: 2183 TEKNYNVNIWV-------PPNIGGSDELTQLTVIEGNLISLLCES----SGIPPPNLIWK 2231
Query: 282 MKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNG 338
KG + + G +R+L G +++++++ ++D A Y+C N G
Sbjct: 2232 KKGSPVLTD-----SMGRVRILS---GGRQLQISI----AEKSDAALYSCVASNVAG 2276
Score = 37.4 bits (85), Expect = 0.047
Identities = 45/185 (24%), Positives = 72/185 (38%), Gaps = 25/185 (13%)
Query: 110 DSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFK 169
D+G YTCV N ++L V + + + S VT + C +
Sbjct: 766 DAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVT----LPC-----YV 816
Query: 170 KSDQEPDVVWYKE------CKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLV 223
+ EP + W + +P SI + AL I + D G Y CE + + +
Sbjct: 817 QGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKI 876
Query: 224 RRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
+ T + VT L+ PL + PSV +V G+ L +PC +G P W+K
Sbjct: 877 QSETTVTVTGLVA-----PLIGI--SPSVANVIEGQQLTLPCTL---LAGNPIPERRWIK 926
Query: 284 GEKFI 288
+
Sbjct: 927 NSAML 931
Score = 37.4 bits (85), Expect = 0.047
Identities = 64/310 (20%), Positives = 100/310 (32%), Gaps = 62/310 (20%)
Query: 35 SVDLKTYMALAGEPVRVKCALFYSYIRTNYSTAQSTGLR---LMWYKNKGDLEEPIIFSE 91
S LK Y+ +P+ + C ++ GL + W+K+ + E I
Sbjct: 4082 SPHLKEYVIAVDKPITLSC--------------EADGLPPPDITWHKDGRAIVESIR--- 4124
Query: 92 VRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLE- 150
+ S+ + D+G YTC+ N S LTV RIR E
Sbjct: 4125 -QRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVH-------VPPRIRSTEG 4176
Query: 151 KSEVTKRKEISCPDMDDFKKSDQEPDVVWYKE--CKPKMWRSIIIQKGNALLIQEVQEED 208
V + + P + D P + W K+ + + L+++ V ED
Sbjct: 4177 HYTVNENSQAILPCVAD---GIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLED 4233
Query: 209 GGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAF 268
G YTC T L V L T P + + G+ L + CKA
Sbjct: 4234 SGFYTCVANNAAGEDTHTVSLTVHVLPT---------FTELPGDVSLNKGEQLRLSCKA- 4283
Query: 269 FGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLAN 328
+G P + W ++ H L+ + V + D
Sbjct: 4284 ---TGIPLPKLTWTFNN---------------NIIPAHFDSVNGHSELVIERVSKEDSGT 4325
Query: 329 YTCHVENRNG 338
Y C EN G
Sbjct: 4326 YVCTAENSVG 4335
Score = 35.8 bits (81), Expect = 0.14
Identities = 27/91 (29%), Positives = 37/91 (40%), Gaps = 13/91 (14%)
Query: 193 IQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSV 252
I A+ I Q G YTC + R L V +PP ++ QPS
Sbjct: 3946 ILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHV-----HEPPV----IQPQPSE 3996
Query: 253 IDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
+ V L P+ +PC+A +G P I W K
Sbjct: 3997 LHVILNNPILLPCEA----TGTPSPFITWQK 4023
Score = 35.0 bits (79), Expect = 0.23
Identities = 57/281 (20%), Positives = 102/281 (36%), Gaps = 34/281 (12%)
Query: 76 WYKNKGDL-EEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVA 134
W KN L + P I + + S+ + QD G YTCV N + S+ V
Sbjct: 924 WIKNSAMLLQNPYI-----TVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVH 978
Query: 135 ENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQ 194
+ + +E VT + C + +P V+W K+ + S
Sbjct: 979 VLPTIQHGQQILSTIEGIPVT----LPCK-----ASGNPKPSVIWSKKGELISTSSAKFS 1029
Query: 195 KG--NALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKV---TALLTDKPPKPLFPMENQ 249
G +L + E+ G Y C +R +L V + D+ +++
Sbjct: 1030 AGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGL----SQDK 1085
Query: 250 PSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGH---IREGEIRLLKEH 306
P I V G+ + +PC+ P+I W K + I + + G +++ +
Sbjct: 1086 PVEISVLAGEEVTLPCEV----KSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETR 1141
Query: 307 LGEKEVELAL---IFDSVVEADLANYTCHVENRNGRKHASV 344
+ + L + I +V +A N + + G KH V
Sbjct: 1142 TSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKV 1182
Score = 35.0 bits (79), Expect = 0.23
Identities = 51/249 (20%), Positives = 91/249 (36%), Gaps = 50/249 (20%)
Query: 109 QDSGFYTCVLRNSTYCMKVSMSLTVAE----NESGLCYNSRIRYLEKSEVTKRKEISCPD 164
+D+G YTCV N+ + + L V E ++G N + V+ ++ C
Sbjct: 1891 EDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVL------VSNPVQLECK- 1943
Query: 165 MDDFKKSDQEPDVVWYKECKPKMWRSII--IQKGNALLIQEVQEEDGGNYTC-ELKYEGK 221
+ P + WYK+ + + + + +G + I+ Q D G Y C + G
Sbjct: 1944 ----AAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAG- 1998
Query: 222 LVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
TEL + + P + +++ V + P+ + C+A G P + W
Sbjct: 1999 ----ATELFYSLQVHVAPS-----ISGSNNMVAVVVNNPVRLECEA----RGIPAPSLTW 2045
Query: 282 MKGEKFIEELAGHIRE---GEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNG 338
+K + + ++ G I L S +D YTC N G
Sbjct: 2046 LKDGSPVSSFSNGLQVLSGGRI---------------LALTSAQISDTGRYTCVAVNAAG 2090
Query: 339 RKHASVLLR 347
K + LR
Sbjct: 2091 EKQRDIDLR 2099
Score = 32.0 bits (71), Expect = 2.0
Identities = 54/238 (22%), Positives = 83/238 (34%), Gaps = 54/238 (22%)
Query: 74 LMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQ--DSGFYTCVLRNSTYCMKVSMSL 131
+ WYK+ +PI+ S + ++ + H AQ DS YTC + N + S +
Sbjct: 1579 ITWYKDG----QPIMSSSQALYIDKGQ-YLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633
Query: 132 TV-----AENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKP- 185
V E N ++ + + C + P + W K+ P
Sbjct: 1634 DVYVPPMIEGNLATPLNKQV------VIAHSLTLECK-----AAGNPSPILTWLKDGVPV 1682
Query: 186 KMWRSIIIQKGNALL-IQEVQEEDGGNYTC---------ELKYEGKLVRRTTELKVTALL 235
K +I I+ G L I QE D G Y C E+KYE
Sbjct: 1683 KANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYE---------------- 1726
Query: 236 TDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAG 293
D P ++ S V + L + C +G P I W+K + I+E G
Sbjct: 1727 VDVLVPPAIEGGDETSYFIVMVNNLLELDCHV----TGSPPPTIMWLKDGQLIDERDG 1780
Score = 32.0 bits (71), Expect = 2.0
Identities = 59/287 (20%), Positives = 97/287 (33%), Gaps = 55/287 (19%)
Query: 74 LMWYKNKGDLEEPIIFSE---VRMSKEEDSIWFHSAEAQDSGFYTCVLRNST------YC 124
+ W K+ +PI E +R+S ++ + A D+G YTCV N +
Sbjct: 3278 IQWLKDG----KPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFN 3333
Query: 125 MKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECK 184
+ V ++ T+ N+ +++E + +++ P + W K
Sbjct: 3334 LNVYVTPTIRGNK------------DEAEKLMTLVDTSINIECRATGTPPPQINWLKNGL 3381
Query: 185 PKMWRSII--IQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKP 242
P S I + G + I Q D YTC + + L+V A PP
Sbjct: 3382 PLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFA-----PPN- 3435
Query: 243 LFPMENQPSV--IDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEI 300
M+N I V G ++ C G P + W +R+G+
Sbjct: 3436 ---MDNSMGTEEITVLKGSSTSMACIT----DGTPAPSMAW-------------LRDGQP 3475
Query: 301 RLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLR 347
L HL + L D YTC N G +L+
Sbjct: 3476 LGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILK 3522
Score = 31.2 bits (69), Expect = 3.3
Identities = 25/98 (25%), Positives = 45/98 (45%), Gaps = 11/98 (11%)
Query: 177 VVWYKECKP-KMWRSI-IIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTAL 234
+ W+K+ P + R+I I+ G L I QE++ G Y+C E + + E+KV
Sbjct: 2607 ITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYI- 2665
Query: 235 LTDKPP----KPLFPMENQPSVIDVQLGKPLNIPCKAF 268
PP L+ P + +++ L + C+A+
Sbjct: 2666 ----PPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699
Score = 31.2 bits (69), Expect = 3.3
Identities = 41/186 (22%), Positives = 66/186 (35%), Gaps = 19/186 (10%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDM 165
A+ +D+G YTCV N + + V NS + V K I C
Sbjct: 2838 AKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIEC--- 2894
Query: 166 DDFKKSDQEPDVVWYKECKPKMW--RSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLV 223
P W K+ +P + + G L I Q D G Y C +
Sbjct: 2895 --LSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSA 2952
Query: 224 RRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
++ L V PP + P +V+ + +++ C+ SG P + W+K
Sbjct: 2953 KKYFNLNVHV-----PPSVIGPKSENLTVV---VNNFISLTCEV----SGFPPPDLSWLK 3000
Query: 284 GEKFIE 289
E+ I+
Sbjct: 3001 NEQPIK 3006
Score = 30.4 bits (67), Expect = 5.7
Identities = 52/245 (21%), Positives = 80/245 (32%), Gaps = 40/245 (16%)
Query: 105 SAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPD 164
+ + +G YTCV RN+ ++L V E S + + + + E +
Sbjct: 3956 ATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEAT--- 4012
Query: 165 MDDFKKSDQEPDVVWYKE--CKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKL 222
P + W KE R+ + L I ED G Y C +
Sbjct: 4013 ------GTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGT 4066
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWM 282
+L V P+ + VI V KP+ + C+A G P I W
Sbjct: 4067 ALGKIKLNVQV-------PPVISPHLKEYVIAVD--KPITLSCEA----DGLPPPDITWH 4113
Query: 283 K-GEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKH 341
K G +E + + L +++A V D +YTC N G
Sbjct: 4114 KDGRAIVESIRQRV-----------LSSGSLQIAF----VQPGDAGHYTCMAANVAGSSS 4158
Query: 342 ASVLL 346
S L
Sbjct: 4159 TSTKL 4163
Score = 29.6 bits (65), Expect = 9.7
Identities = 40/174 (22%), Positives = 61/174 (35%), Gaps = 31/174 (17%)
Query: 198 ALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQL 257
+L ++ V+ D G Y C + EG + L V +PPK +NQ
Sbjct: 575 SLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTV-----QEPPKVTVMPKNQ----SFTG 625
Query: 258 GKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALI 317
G ++I C A +G P I W + FI + H + L
Sbjct: 626 GSEVSIMCSA----TGYPKPKIAWTVNDMFI--------------VGSHRYRMTSDGTLF 667
Query: 318 FDSVVEADLANYTCHVENRNGRKHASVLLR----KKDLIYKIELAGGLGAIFLL 367
+ D Y C N G + LR K ++ + EL LG I ++
Sbjct: 668 IKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVM 721
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 56.2 bits (134), Expect = 1e-07
Identities = 75/299 (25%), Positives = 115/299 (38%), Gaps = 51/299 (17%)
Query: 64 YSTAQSTGLRLMWYKNKGDLEEPIIFSE---VRMSKEEDSIWFHSAEAQDSGFYTCVLRN 120
Y+ A + L+ WYK+ P++ S+ + + F+SAE DSG YT + N
Sbjct: 4038 YTVAGTPELKPKWYKDG----RPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISN 4093
Query: 121 STYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEP-DVVW 179
+ TV + + + +R ++ S V + C K + P V W
Sbjct: 4094 EVGSSSCETTFTVLDRDIAPFFTKPLRNVD-SVVNGTCRLDC------KIAGSLPMRVSW 4146
Query: 180 YKECK----PKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTEL----KV 231
+K+ K +R ++ +L I V D GN+TC R T +
Sbjct: 4147 FKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNFTC---------RATNSVGSKDSS 4197
Query: 232 TALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEEL 291
AL+ +PP +P DV G + + F G + I W KG K +
Sbjct: 4198 GALIVQEPPS----FVTKPGSKDVLPGSAVCLKST----FQGSTPLTIRWFKGNKEL--- 4246
Query: 292 AGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKD 350
+ G + KE L E +EL L+ S D YTC V N G S L K+
Sbjct: 4247 ---VSGGSCYITKEAL-ESSLELYLVKTS----DSGTYTCKVSNVAGGVECSANLFVKE 4297
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/280 (22%), Positives = 103/280 (36%), Gaps = 34/280 (12%)
Query: 76 WYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAE 135
WYK L P ++ ++ F+ + DSG Y C NS + S LTV E
Sbjct: 7994 WYKGDTKLR-PTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQE 8052
Query: 136 NESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEP-DVVWYKECKP----KMWRS 190
+ ++ ++R ++++ + P + D S EP V WYK+ KP ++
Sbjct: 8053 QKLPPSFSRQLRDVQET-------VGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQT 8105
Query: 191 IIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQP 250
+ L I + G Y+C + L +LT+ P F + P
Sbjct: 8106 SFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARL----ILTEGKNPPFFDIRLAP 8161
Query: 251 SVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEK 310
+D +G+ + C +G + W K + IR G K +
Sbjct: 8162 --VDAVVGESADFECHV----TGTQPIKVSWAKDSR-------EIRSGG----KYQISYL 8204
Query: 311 EVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKD 350
E L V + D YTC+ N G+ + L K+
Sbjct: 8205 ENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKE 8244
Score = 47.8 bits (112), Expect = 3e-05
Identities = 68/310 (21%), Positives = 121/310 (39%), Gaps = 35/310 (11%)
Query: 67 AQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMK 126
A S + + WYKN +++ P E+ + A D+G YTC + N
Sbjct: 8274 AGSQPITVAWYKNNIEIQ-PTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSAL 8332
Query: 127 VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYK---EC 183
+ S+ + E + ++ + + SE + ++SC + + + W K E
Sbjct: 8333 CTSSIVIKEPKKPPVFDQHLTPVTVSE-GEYVQLSC-----HVQGSEPIRIQWLKAGREI 8386
Query: 184 KPKMWRSIIIQKGNALL-IQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKP 242
KP S G A+L +++V + D G+Y C K TT+ KVT + DKP
Sbjct: 8387 KPSDRCSFSFASGTAVLELRDVAKADSGDYVC--KASNVAGSDTTKSKVT--IKDKP--A 8440
Query: 243 LFPMENQPSV----IDVQLGKPLNIPCKAFFGF----SGESGPMIYWMKGEKFIEELAGH 294
+ P + +V V + + + K F G+ P + W KG+ G
Sbjct: 8441 VAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGR 8500
Query: 295 IREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYK 354
+ + +K E L + D Y C N +G ++V L+ + +
Sbjct: 8501 V----------FIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKKQ 8550
Query: 355 IELAGGLGAI 364
++ G L A+
Sbjct: 8551 EKIEGDLRAM 8560
Score = 47.0 bits (110), Expect = 6e-05
Identities = 44/155 (28%), Positives = 64/155 (41%), Gaps = 23/155 (14%)
Query: 189 RSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMEN 248
R I K L I +VQ D G YTC L+ K T +L V L P + + +E
Sbjct: 11165 RFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEEL----PVRFVKTLEE 11220
Query: 249 QPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLG 308
+ +V+ G+PL + C+ + W K K + E G I G I L++
Sbjct: 11221 EVTVVK---GQPLYLSCEL------NKERDVVWRKDGKIVVEKPGRIVPGVIGLMR---- 11267
Query: 309 EKEVELALIFDSVVEADLANYTCHVENRNGRKHAS 343
AL + + D YT VEN N + +S
Sbjct: 11268 ------ALTINDADDTDAGTYTVTVENANNLECSS 11296
Score = 46.6 bits (109), Expect = 8e-05
Identities = 81/334 (24%), Positives = 124/334 (37%), Gaps = 58/334 (17%)
Query: 35 SVDLKTYMALAGEPVRVKCALFYSYIRTNYSTAQST-----GLRLMWYKNKGDLEEPIIF 89
S T +AL P +K + + + +T QST + + W K+ L+E
Sbjct: 5035 SCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDED--- 5091
Query: 90 SEVRMSKEED--SIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGL--CYNSR 145
V +S + ++ S + SG YTC A+NESG+ CY
Sbjct: 5092 DNVYISFVDSVATLQIRSVDNGHSGRYTCQ----------------AKNESGVERCYAFL 5135
Query: 146 IRYLEKSEVTKRKEISCPDMDDFK-----KSDQEPDVVWYKECK---PKMWRSIIIQKGN 197
+ V K K + + D E V W K+ K P + S+ +
Sbjct: 5136 LVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNV 5195
Query: 198 ALL-IQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQ 256
A IQ V ++D G YT K E + + + L + PP + + +D
Sbjct: 5196 ASFRIQSVMKQDSGQYT--FKVENDFGSSSCDAYLRVLDQNIPPS----FTKKLTKMDKV 5249
Query: 257 LGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELAL 316
LG +++ CK SG W K K I A K L E ++L
Sbjct: 5250 LGSSIHMECKV----SGSLPISAQWFKDGKEISTSA-----------KYRLVCHERSVSL 5294
Query: 317 IFDSVVEADLANYTCHVENRNGRKHASVLLRKKD 350
+++ D ANYTC V N G S +L K+
Sbjct: 5295 EVNNLELEDTANYTCKVSNVAGDDACSGILTVKE 5328
Score = 43.5 bits (101), Expect = 6e-04
Identities = 77/309 (24%), Positives = 124/309 (40%), Gaps = 50/309 (16%)
Query: 69 STGLRLMWYKNKGDLEEPIIFSEVRMSKE--EDSIWFHSAEAQDSGFYTCVLRNSTYCMK 126
ST L + W+K +L + ++KE E S+ + + DSG YTC + N ++
Sbjct: 4232 STPLTIRWFKGNKEL---VSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVE 4288
Query: 127 VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEP-DVVWY---KE 182
S +L V E + + + L+K + T +++C K + P + W+ +E
Sbjct: 4289 CSANLFVKEPATFVEKLEPSQLLKKGDAT---QLAC------KVTGTPPIKITWFANDRE 4339
Query: 183 CKPKMWRSIIIQKGNALL-IQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPK 241
K + + A+L + +V ED G Y CE + E ++ + V
Sbjct: 4340 IKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIV-------KES 4392
Query: 242 PLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIR 301
P F E +P +++ K ++ A +G I W K +R G R
Sbjct: 4393 PYFTKEFKP----IEVLKEYDVMLLA--EVAGTPPFEITWFKDNTI-------LRSG--R 4437
Query: 302 LLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRK--HASVLLRK-KDLIYKIE-- 356
K + + V L ++ V AD Y C V N G A V LR+ I KIE
Sbjct: 4438 KYKTFIQDHLVSLQIL--KFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIEST 4495
Query: 357 --LAGGLGA 363
L GG A
Sbjct: 4496 SSLRGGTAA 4504
Score = 42.4 bits (98), Expect = 0.001
Identities = 64/321 (19%), Positives = 122/321 (38%), Gaps = 52/321 (16%)
Query: 45 AGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDS--IW 102
AG+ R++C + A S +R++W++N+ +L + RM+ + I
Sbjct: 5437 AGDSSRLECKI-----------AGSPEIRVVWFRNEHELPAS---DKYRMTFIDSVAVIQ 5482
Query: 103 FHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISC 162
++ +DSG + C +N S + V E + + L+ +EV+ E+S
Sbjct: 5483 MNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELS- 5541
Query: 163 PDMDDFKKSDQEPDVVWYKECK----PKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKY 218
+VVWYK+ + K ++ ++ I V D G Y C+ +
Sbjct: 5542 --------GTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQN 5593
Query: 219 EGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPM 278
E ++ V + +PP+ + + + + V G+P + G
Sbjct: 5594 E-----VGSDTCVCTVKLKEPPRFVSKLNS----LTVVAGEPAELQA----SIEGAQPIF 5640
Query: 279 IYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNG 338
+ W+K ++ + IRE E + E L F A+ Y C ++N G
Sbjct: 5641 VQWLKEKEEV------IRESE----NIRITFVENVATLQFAKAEPANAGKYICQIKNDGG 5690
Query: 339 RKHASVLLRKKDLIYKIELAG 359
+ L + +E AG
Sbjct: 5691 MRENMATLMVLEPAVIVEKAG 5711
Score = 40.4 bits (93), Expect = 0.005
Identities = 61/284 (21%), Positives = 108/284 (38%), Gaps = 41/284 (14%)
Query: 69 STGLRLMWYKNKGDLEEPIIFSEVRMSKEEDS--IWFHSAEAQDSGFYTCVLRNSTYCMK 126
S ++++WYK++ +++E S+ RMS + + H+ +DSG YTC N+
Sbjct: 7332 SPEIKVLWYKDETEIQES---SKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSAS 7388
Query: 127 VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKP- 185
S SL V E I L+ ++V E+ + V WYK+ +
Sbjct: 7389 SSTSLKVKEPPIFRKKPHPIETLKGADVHLECEL---------QGTPPFHVSWYKDKREL 7439
Query: 186 ---KMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKP 242
K ++ + ++ I V D G Y C+ + ++ V ++ PP+
Sbjct: 7440 RSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATND-----VGSDTCVGSIALKAPPR- 7493
Query: 243 LFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRL 302
+ S I +GK + + G + W K + I +RE +
Sbjct: 7494 ---FVKKLSDISTVVGKEVQLQTT----IEGAEPISVVWFKDKGEI------VRESD--- 7537
Query: 303 LKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
+ E L F V A+ YTC ++N G + L
Sbjct: 7538 -NIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATL 7580
Score = 40.0 bits (92), Expect = 0.007
Identities = 61/243 (25%), Positives = 96/243 (39%), Gaps = 52/243 (21%)
Query: 46 GEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHS 105
G+P R +C + T L++ WY ++ F RM++ ED+
Sbjct: 3359 GQPARFQCRV------------SGTDLKVSWYSKDKKIKPSRFF---RMTQFEDTYQLEI 3403
Query: 106 AEA--QDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRY-----LEKSEVTKRK 158
AEA +D G YT V N+ + + +L++ ES L + RI ++ + V KRK
Sbjct: 3404 AEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESIL--HERIEQEIEMEMKAAPVIKRK 3461
Query: 159 ----EISCPDMDDFKKSDQEPDVV---WYK---------ECKPKMWRSIIIQKGNALLIQ 202
E++ + F Q V W+K +C + + I ++L I
Sbjct: 3462 IEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYI-----SSLEIL 3516
Query: 203 EVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLN 262
Q D G YTC+ E V T L VT PP L ++P + +GK
Sbjct: 3517 RTQVVDCGEYTCKASNEYGSVSCTATLTVTEAY---PPTFL----SRPKSLTTFVGKAAK 3569
Query: 263 IPC 265
C
Sbjct: 3570 FIC 3572
Score = 39.3 bits (90), Expect = 0.012
Identities = 69/311 (22%), Positives = 111/311 (35%), Gaps = 51/311 (16%)
Query: 38 LKTYMALAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKE 97
LK L+G V ++C ++ S + + W+ ++ + + ++
Sbjct: 7688 LKETNGLSGSSVVMECKVY-----------GSPPISVSWFHEGNEISSGRKY-QTTLTDN 7735
Query: 98 EDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKR 157
++ + E DSG YTC+ N + S LTV E S + + L + VT
Sbjct: 7736 TCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVT-- 7793
Query: 158 KEISCPDMDDFKKSDQEPDVVWYK---ECKPKMWRSIIIQKGNA-LLIQEVQEEDGGNYT 213
K V W+K E P ++ ++ A L + +V G YT
Sbjct: 7794 -------FTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYT 7846
Query: 214 CELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSG 273
C + E TT L + K P N S ++ GKPL + F+G
Sbjct: 7847 CIVSNEAGKASCTTHLYI------KAPAKFVKRLNDYS---IEKGKPLILEGT----FTG 7893
Query: 274 ESGPMIYWMK-GEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCH 332
+ W K G +I E + E I S VE D Y C+
Sbjct: 7894 TPPISVTWKKNGINVTPSQRCNITTTEKSAILE-----------IPSSTVE-DAGQYNCY 7941
Query: 333 VENRNGRKHAS 343
+EN +G+ S
Sbjct: 7942 IENASGKDSCS 7952
Score = 38.9 bits (89), Expect = 0.016
Identities = 33/143 (23%), Positives = 56/143 (39%), Gaps = 13/143 (9%)
Query: 198 ALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDK--PPKPLFPMENQPSVIDV 255
+ L++ + E Y +K ++ L + ++ D PP + + I V
Sbjct: 15353 SFLVENLDEHQ--MYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKV 15410
Query: 256 QLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELA 315
+ G+P++IP +G P I W K E IE+ +++ KE + E +
Sbjct: 15411 KAGEPVHIPADV----TGLPMPKIEWSKNETVIEKPTD-----ALQITKEEVSRSEAKTE 15461
Query: 316 LIFDSVVEADLANYTCHVENRNG 338
L V D YT NR G
Sbjct: 15462 LSIPKAVREDKGTYTVTASNRLG 15484
Score = 38.1 bits (87), Expect = 0.027
Identities = 42/143 (29%), Positives = 59/143 (41%), Gaps = 12/143 (8%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDM 165
A DSG +T V +N +S+ LTV E + + ++EK + KE S +M
Sbjct: 1520 ATPSDSGEWTVVAQNRAGRSSISVILTVEAVE----HQVKPMFVEKLKNVNIKEGSRLEM 1575
Query: 166 DDFKKSDQEPDVVWYKECK---PKMWRSIIIQ--KGNALL-IQEVQEEDGGNYTCELKYE 219
+ PD+VW K P + I I+ KG A L I +D YT
Sbjct: 1576 KVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATA--I 1633
Query: 220 GKLVRRTTELKVTALLTDKPPKP 242
K R TT KV + P+P
Sbjct: 1634 NKAGRDTTRCKVNVEVEFAEPEP 1656
Score = 38.1 bits (87), Expect = 0.027
Identities = 46/184 (25%), Positives = 76/184 (41%), Gaps = 34/184 (18%)
Query: 110 DSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFK 169
D Y+C +R + + S LTV E E+ + + +E SE K + +
Sbjct: 12439 DEAEYSCEVRTA----RTSGMLTVLEEEA--VFTKNLANIEVSETDTIKLVC-------E 12485
Query: 170 KSDQEPDVVWYKECKP--KMWRSIIIQKGNA--LLIQEVQEEDGGNYTCELKYEGKLVRR 225
S +V+WYK + + R I+ +G L+IQ ED GNY C L R
Sbjct: 12486 VSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSS----RT 12541
Query: 226 TTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGE 285
++KV L + ++P +++ G+ C S ES P + W + +
Sbjct: 12542 DGKVKVHELAAE--------FISKPQNLEILEGEKAEFVC----SISKESFP-VQWKRDD 12588
Query: 286 KFIE 289
K +E
Sbjct: 12589 KTLE 12592
Score = 37.7 bits (86), Expect = 0.036
Identities = 59/240 (24%), Positives = 93/240 (38%), Gaps = 40/240 (16%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDM 165
A+ +DSG Y C N S ++TV E S ++ ++ S + E + +
Sbjct: 3706 AKLKDSGTYVCTASNEAGSSSCSATVTVREPP------SFVKKVDPSYLMLPGESA--RL 3757
Query: 166 DDFKKSDQEPDVVWYKECK----PKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGK 221
K V W+K K R + L I +V+ ED G+Y+CE +
Sbjct: 3758 HCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVG 3817
Query: 222 LVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
+TE+ + K P P F +P+ D+ G + C+ SG I W
Sbjct: 3818 SDSCSTEIVI------KEP-PSFIKTLEPA--DIVRGTNALLQCEV----SGTGPFEISW 3864
Query: 282 MKGEKFIEELAGHIREGEIRLLKEH--LGEKEVELALIFDSVVEADLANYTCHVENRNGR 339
K +K +IR K++ +K + IF S AD+ Y C V N G+
Sbjct: 3865 FKDKK------------QIRSSKKYRLFSQKSLVCLEIF-SFNSADVGEYECVVANEVGK 3911
Score = 37.7 bits (86), Expect = 0.036
Identities = 41/182 (22%), Positives = 73/182 (40%), Gaps = 25/182 (13%)
Query: 42 MALAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSI 101
+A GE ++++C + + S +++ W++N +L E ++ + +
Sbjct: 6375 VAKQGESIQLECKI-----------SGSPEIKVSWFRNDSELHESWKYN-MSFINSVALL 6422
Query: 102 WFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEIS 161
+ A A+DSG Y C N S +LTV S + L+ S+V + EIS
Sbjct: 6423 TINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEIS 6482
Query: 162 CPDMDDFKKSDQEPDVVWYKECK----PKMWRSIIIQKGNALLIQEVQEEDGGNYTCELK 217
+VVW K+ K K ++ +L I ++ D G Y C+
Sbjct: 6483 ---------GTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKAT 6533
Query: 218 YE 219
E
Sbjct: 6534 NE 6535
Score = 37.4 bits (85), Expect = 0.047
Identities = 62/324 (19%), Positives = 108/324 (33%), Gaps = 55/324 (16%)
Query: 37 DLKTYMALAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSK 96
+L+ A G+ V ++C + A + + + WYK L P +
Sbjct: 6084 ELEPLEAAVGDSVSLQCQV-----------AGTPEITVSWYKGDTKLR-PTPEYRTYFTN 6131
Query: 97 EEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTK 156
++ F+ DSG YTC NS + E + + +++ +E++
Sbjct: 6132 NVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQT---- 6187
Query: 157 RKEISCPDMDDFKKSDQEP-DVVWYKE----CKPKMWRSIIIQKGNALLIQEVQEEDGGN 211
+ P + + P V WY++ + ++ + L I + G
Sbjct: 6188 ---VGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQ 6244
Query: 212 YTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGF 271
Y+C +A LT + PK + +P IDV G+ + C
Sbjct: 6245 YSCSAS------NPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGESADFECHV---- 6294
Query: 272 SGESGPMIYWMKGEKFIEELAGHI-----REGEIRLLKEHLGEKEVELALIFDSVVEADL 326
+G I W K K I + +R+LK V + D
Sbjct: 6295 TGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILK----------------VGKGDS 6338
Query: 327 ANYTCHVENRNGRKHASVLLRKKD 350
YTC N G+ S L K+
Sbjct: 6339 GQYTCQATNDVGKDMCSAQLSVKE 6362
Score = 37.0 bits (84), Expect = 0.061
Identities = 65/292 (22%), Positives = 101/292 (34%), Gaps = 40/292 (13%)
Query: 72 LRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSL 131
+ + W+K+ +L S V S+ +A+A DSG Y C L N +L
Sbjct: 4797 MTIKWFKDNKELHSGAARS-VWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATL 4855
Query: 132 TVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWY---KECKPKMW 188
V E + S + L + T C K V WY E
Sbjct: 4856 FVKEPPQFIKKPSPVLVLRNGQST---TFECQITGTPKIR-----VSWYLDGNEITAIQK 4907
Query: 189 RSIIIQKGNALL-IQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPME 247
I G A I + E+ G Y CE + + + ELKV K P P F E
Sbjct: 4908 HGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKV------KEP-PTFIRE 4960
Query: 248 NQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHL 307
+P ++V + + C+ +G + W+K + I + + + H+
Sbjct: 4961 LKP--VEVVKYSDVELECEV----TGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHI 5014
Query: 308 GEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKD---LIYKIE 356
+ + +D Y C V N G S + K+ I KIE
Sbjct: 5015 TKCD-----------PSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIE 5055
Score = 36.6 bits (83), Expect = 0.079
Identities = 62/254 (24%), Positives = 94/254 (37%), Gaps = 37/254 (14%)
Query: 107 EAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMD 166
E D+G YTCV N + S LTV E S + L +T I
Sbjct: 6804 EPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIR--GTP 6861
Query: 167 DFKKSDQEPDVVWYK---ECKPKMWRSIIIQK-GNALLIQEVQEEDGGNYTCELKYEGKL 222
FK V W+K E P +I ++ L + EVQ + G+Y+C + +
Sbjct: 6862 PFK-------VKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGS 6914
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWM 282
TT L V T + + V+ G P+ + ++G + W+
Sbjct: 6915 ASCTTHLFVKEPAT---------FVKRLADFSVETGSPIVLEAT----YTGTPPISVSWI 6961
Query: 283 KGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHA 342
K E I + + EK L I +S +E D A Y+C +EN G+
Sbjct: 6962 KDEYLI---------SQSERCSITMTEKSTILE-ILESTIE-DYAQYSCLIENEAGQDIC 7010
Query: 343 SVLLRKKDLIYKIE 356
L+ + Y IE
Sbjct: 7011 EALVSVLEPPYFIE 7024
Score = 36.2 bits (82), Expect = 0.10
Identities = 64/292 (21%), Positives = 112/292 (38%), Gaps = 49/292 (16%)
Query: 76 WYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAE 135
W K+ ++ E + K+ + + D+G YTCVLR + L V E
Sbjct: 11151 WMKDGSNIRESPKHRFIADGKDR-KLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEE 11209
Query: 136 NESGLCYNSRIRYLE--KSEVTKRK----EISCPDMDDFKKSDQEPDVVWYKECK---PK 186
+R+++ + EVT K +SC + ++E DVVW K+ K K
Sbjct: 11210 --------LPVRFVKTLEEEVTVVKGQPLYLSC-------ELNKERDVVWRKDGKIVVEK 11254
Query: 187 MWRSI--IIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLF 244
R + +I AL I + + D G YT ++ L ++ +KV ++ D KP+
Sbjct: 11255 PGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNL-ECSSCVKVVEVIRDWLVKPIR 11313
Query: 245 PMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLK 304
+P + F + P I W KG +E+ + K
Sbjct: 11314 DQHVKPKGTAI------------FACDIAKDTPNIKWFKG---YDEIPAEPND------K 11352
Query: 305 EHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKDLIYKIE 356
+ L L + + D+A Y +E + ++ R+ +L+ IE
Sbjct: 11353 TEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREVELLKPIE 11404
Score = 35.8 bits (81), Expect = 0.14
Identities = 53/246 (21%), Positives = 88/246 (35%), Gaps = 39/246 (15%)
Query: 107 EAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMD 166
+ SG YTCV+ N+ + L V E + L + L V K I ++
Sbjct: 5956 DISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFL------KRLSDHSVEPGKSII---LE 6006
Query: 167 DFKKSDQEPDVVWYKE----CKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKL 222
V W K+ + + +K L I + D G Y+CE++ E
Sbjct: 6007 STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGR 6066
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWM 282
V L P F E +P ++ +G +++ C+ +G + W
Sbjct: 6067 -------DVCGALVSTLEPPYFVTELEP--LEAAVGDSVSLQCQV----AGTPEITVSWY 6113
Query: 283 KGEKFIEELAGHIREGEIRLLKEHLGEKEVELA-LIFDSVVEADLANYTCHVENRNGRKH 341
KG+ ++R E+ +A L+F+ V D YTC EN G
Sbjct: 6114 KGDT------------KLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTAS 6161
Query: 342 ASVLLR 347
+ + R
Sbjct: 6162 SKTVFR 6167
Score = 35.8 bits (81), Expect = 0.14
Identities = 47/184 (25%), Positives = 82/184 (44%), Gaps = 29/184 (15%)
Query: 54 ALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGF 113
A+F I+ NY ++L WYK LE F E+ + + ++ + + +D G
Sbjct: 8673 AVFEIDIKINYPE-----IKLSWYKGTEKLEPSDKF-EISIDGDRHTLRVKNCQLKDQGN 8726
Query: 114 YTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQ 173
Y V S LTV E + R+L+ +VT ++ +C F +
Sbjct: 8727 YRLVCGPHI----ASAKLTVIEP-------AWERHLQ--DVTLKEGQTCTMTCQFSVPNV 8773
Query: 174 EPDVVWYKE---CKPK-MWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTEL 229
+ + W++ KP+ ++ + K + L I +V+ ED G YTC KYE + + EL
Sbjct: 8774 KSE--WFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTC--KYED--LETSAEL 8827
Query: 230 KVTA 233
++ A
Sbjct: 8828 RIEA 8831
Score = 35.4 bits (80), Expect = 0.18
Identities = 64/278 (23%), Positives = 110/278 (39%), Gaps = 45/278 (16%)
Query: 74 LMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQ--DSGFYTCVLRNST-YCMKVSMS 130
L W K + D + I+ V + DS W S + + D F L +T Y +V
Sbjct: 30449 LQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQFTIGGLLEATEYEFRV--- 30505
Query: 131 LTVAENESGLCYNSRIRYLEKSEVT---------KRKEISCPDMDDFKKSDQE-----PD 176
AENE+GL R K+++T + K+++ + + S Q PD
Sbjct: 30506 --FAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPD 30563
Query: 177 VVWYKECKP----KMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVT 232
+ WY+ K + ++ + + L + ++ED G YTC E V +++L +
Sbjct: 30564 IKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ 30623
Query: 233 ALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFI---E 289
A P PL E + L + + G P + W G+K + E
Sbjct: 30624 ATPQFHPGYPL--KEKYYGAVGSTL--------RLHVMYIGRPVPAMTWFHGQKLLQNSE 30673
Query: 290 ELAGHIREGEIRLL------KEHLGEKEVELALIFDSV 321
+ E L+ K H G+ +V+L+ +F +V
Sbjct: 30674 NITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTV 30711
Score = 34.7 bits (78), Expect = 0.30
Identities = 64/282 (22%), Positives = 104/282 (36%), Gaps = 41/282 (14%)
Query: 72 LRLMWYKNKGDLEEPIIFSEVRMSKEED--SIWFHSAEAQDSGFYTCVLRNSTYCMKVSM 129
L++ W K+ + FS MS E + S S QDSG YT + N
Sbjct: 5170 LKVKWLKDGKQIVPSRYFS---MSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDA 5226
Query: 130 SLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKP---- 185
L V + + ++ ++K + + C S Q W+K+ K
Sbjct: 5227 YLRVLDQNIPPSFTKKLTKMDKV-LGSSIHMECKVSGSLPISAQ-----WFKDGKEISTS 5280
Query: 186 KMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDK-PPKPLF 244
+R + ++ +L + ++ ED NYTC K+ + + +LT K PP L
Sbjct: 5281 AKYRLVCHERSVSLEVNNLELEDTANYTC------KVSNVAGDDACSGILTVKEPPSFLV 5334
Query: 245 PMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLK 304
Q ++ D + KA G I W K + +E ++G K
Sbjct: 5335 KPGRQQAIPDS------TVEFKAIL--KGTPPFKIKWFKDD--VELVSGP---------K 5375
Query: 305 EHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
+G + L SV + YTCHV N G + +L
Sbjct: 5376 CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTML 5417
Score = 33.9 bits (76), Expect = 0.51
Identities = 47/185 (25%), Positives = 74/185 (40%), Gaps = 26/185 (14%)
Query: 174 EPDVVWYKECKPKMWRSIIIQ----KG--NALLIQEVQEEDGGNYTCELKYEGKLVRRTT 227
+P V WY++ K + + + KG + L+I V ++D Y +G V T
Sbjct: 30956 KPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTA 31015
Query: 228 ELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKF 287
L+V PK L M + G+ ++I FSG+ P+I W KG+
Sbjct: 31016 SLEVEVPAKIHLPKTLEGM----GAVHALRGEVVSIKIP----FSGKPDPVITWQKGQDL 31067
Query: 288 IEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVE-ADLANYTCHVENRNGRKHASVLL 346
I+ GH + R +L+F + VE D Y +NR G +V L
Sbjct: 31068 IDN-NGHYQVIVTRSF----------TSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVEL 31116
Query: 347 RKKDL 351
D+
Sbjct: 31117 DVADV 31121
Score = 33.9 bits (76), Expect = 0.51
Identities = 49/209 (23%), Positives = 70/209 (33%), Gaps = 49/209 (23%)
Query: 176 DVVWYKECKPKMWRSIIIQKGNA-----LLIQEVQEEDGGNYTCELKYEG---------- 220
+V WYK+ K +A L I + E D G Y CE+ EG
Sbjct: 32748 EVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFM 32807
Query: 221 ------------------KLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLN 262
K ++TTE VT K P+P+ ++P ++ ++
Sbjct: 32808 GQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPI---SSKPVIVTGLQDTTVS 32864
Query: 263 IPCKAFFGF--SGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDS 320
A F +GE P W K K I + K L E + L
Sbjct: 32865 SDSVAKFAVKATGEPRPTAIWTKDGKAITQGG-----------KYKLSEDKGGFFLEIHK 32913
Query: 321 VVEADLANYTCHVENRNGRKHASVLLRKK 349
+D YTC V+N G +S L K
Sbjct: 32914 TDTSDSGLYTCTVKNSAGSVSSSCKLTIK 32942
Score = 33.5 bits (75), Expect = 0.67
Identities = 55/250 (22%), Positives = 84/250 (33%), Gaps = 39/250 (15%)
Query: 108 AQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDD 167
A D+G Y C + N S +T+ E S +++K E T
Sbjct: 4457 AADAGEYQCRVTNEVGSSICSARVTLREPPS---------FIKKIESTSSLRGGTAAFQA 4507
Query: 168 FKKSDQEPDVVWYKEC----KPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLV 223
K V W K+ + R +L + ++ + G Y C+ K + +
Sbjct: 4508 TLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQ 4567
Query: 224 RRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
R +ALL+ K P + + IDV G P + K FSG W K
Sbjct: 4568 R------CSALLSVKEPATI---TEEAVSIDVTQGDPATLQVK----FSGTKEITAKWFK 4614
Query: 284 GEKFIEELAGHIREGEIRL-LKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHA 342
+ E+ L K + + L S + D YT V+N GR
Sbjct: 4615 DGQ------------ELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSC 4662
Query: 343 SVLLRKKDLI 352
+ DLI
Sbjct: 4663 KARINVLDLI 4672
Score = 33.1 bits (74), Expect = 0.88
Identities = 45/170 (26%), Positives = 70/170 (41%), Gaps = 27/170 (15%)
Query: 72 LRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSL 131
+R+ W+KN L S K SI F D T +R M L
Sbjct: 11957 IRVKWFKNDQRLHTTRSVSMQDEGKTH-SITFKDLSIDD----TSQIRVEAMGMSSEAKL 12011
Query: 132 TVAENESGLCYNSRIRY---LEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKP-KM 187
TV E + + +++ +EK EV + EIS D V W+K+ K K
Sbjct: 12012 TVLEGDP--YFTGKLQDYTGVEKDEVILQCEISKADAP----------VKWFKDGKEIKP 12059
Query: 188 WRSIIIQ---KGNALLIQEVQEEDGGNYTCEL---KYEGKLVRRTTELKV 231
++ +I+ K L++++ + D G YTC+ K GKL E+K+
Sbjct: 12060 SKNAVIKADGKKRMLILKKALKSDIGQYTCDCGTDKTSGKLDIEDREIKL 12109
Score = 32.7 bits (73), Expect = 1.1
Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 17/102 (16%)
Query: 253 IDVQLGKPLNIPC----KAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLG 308
+D++L K +NI + F G P + W K + G IR+ I +
Sbjct: 22944 LDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVD-------GEIRDAAI------ID 22990
Query: 309 EKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKD 350
+L+ D+V D YT +EN +G K A V +R D
Sbjct: 22991 VTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVLD 23032
Score = 32.0 bits (71), Expect = 2.0
Identities = 49/213 (23%), Positives = 71/213 (33%), Gaps = 54/213 (25%)
Query: 175 PDVVWYKE---CKPKMWRSIIIQKGNA-LLIQEVQEEDGGNYTCELKYEGKLVRRTTEL- 229
P V WY+E + + I Q G A L+I+E ED G +TC E V + L
Sbjct: 972 PTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLA 1031
Query: 230 --------KVTALLTDK---------------------------PPKPLFP-MENQPSVI 253
K T +T+K P +P P +P V
Sbjct: 1032 VQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQ 1091
Query: 254 DVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVE 313
+ G + C+ G P +YW K + G+ K ++ E
Sbjct: 1092 KLVEGGSVVFGCQV----GGNPKPHVYWKKSG--VPLTTGY-------RYKVSYNKQTGE 1138
Query: 314 LALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
L+ D YT V N++G AS L
Sbjct: 1139 CKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 32.0 bits (71), Expect = 2.0
Identities = 15/35 (42%), Positives = 21/35 (60%)
Query: 316 LIFDSVVEADLANYTCHVENRNGRKHASVLLRKKD 350
LI D V D YT EN++G+K A+VL++ D
Sbjct: 29502 LIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYD 29536
Score = 32.0 bits (71), Expect = 2.0
Identities = 16/56 (28%), Positives = 28/56 (50%), Gaps = 2/56 (3%)
Query: 104 HSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKE 159
H + DSG YTC ++NS + S LT+ + ++ + SE+T +K+
Sbjct: 32912 HKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKD--TEAQKVSTQKTSEITPQKK 32965
Score = 31.2 bits (69), Expect = 3.3
Identities = 23/85 (27%), Positives = 38/85 (44%), Gaps = 9/85 (10%)
Query: 199 LLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLG 258
L I++ D G TC K + +V+ +L ++ L+D P +QP ++ G
Sbjct: 33094 LTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDAP-----AFISQPRSQNINEG 33148
Query: 259 KPLNIPCKAFFGFSGESGPMIYWMK 283
+ + C+ SGE P I W K
Sbjct: 33149 QNVLFTCE----ISGEPSPEIEWFK 33169
Score = 30.8 bits (68), Expect = 4.4
Identities = 25/100 (25%), Positives = 40/100 (40%), Gaps = 12/100 (12%)
Query: 38 LKTYMALAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKE 97
LK + GE V ++C + + Y + T WY+ +E I F ++
Sbjct: 949 LKNVTVIEGESVTLECHI------SGYPSPTVT-----WYREDYQIESSIDF-QITFQSG 996
Query: 98 EDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENE 137
+ A A+DSG +TC N + S L V +E
Sbjct: 997 IARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSE 1036
Score = 30.8 bits (68), Expect = 4.4
Identities = 51/249 (20%), Positives = 93/249 (37%), Gaps = 39/249 (15%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDM 165
A ++SG Y C RN S+ L V E + IR L+ EV K ++ ++
Sbjct: 4924 ARVENSGTYVCEARNDAGTASCSIELKVKEPP------TFIRELKPVEVVKYSDV---EL 4974
Query: 166 DDFKKSDQEPDVVWYKECK----PKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGK 221
+ +V W K + K + L I + D G Y C + EG
Sbjct: 4975 ECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGG 5034
Query: 222 LVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
+T + + +PP + +EN +V+ + +G I W
Sbjct: 5035 SCSCSTRVAL-----KEPPSFIKKIENTTTVLKSSATFQSTV--------AGSPPISITW 5081
Query: 282 MKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNG--R 339
+K ++ ++E + + ++ + L SV YTC +N +G R
Sbjct: 5082 LKDDQILDE------DDNV-----YISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVER 5130
Query: 340 KHASVLLRK 348
+A +L+++
Sbjct: 5131 CYAFLLVQE 5139
Score = 30.8 bits (68), Expect = 4.4
Identities = 16/64 (25%), Positives = 31/64 (48%)
Query: 72 LRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSL 131
+ ++W K++G++ + + ++ S EA +SG Y C ++N + S L
Sbjct: 6580 ISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVL 6639
Query: 132 TVAE 135
TV E
Sbjct: 6640 TVLE 6643
Score = 30.8 bits (68), Expect = 4.4
Identities = 24/112 (21%), Positives = 46/112 (41%), Gaps = 15/112 (13%)
Query: 239 PPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREG 298
PPK ++ ++ G L + G+ P I W KG+K ++
Sbjct: 29043 PPKAELDARLHGDLVTIRAGSDLVLDAAV----GGKPEPKIIWTKGDKELDLCE------ 29092
Query: 299 EIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKD 350
++ ++ G++ + D +D YT V+N +G K SV+++ D
Sbjct: 29093 --KVSLQYTGKRATAVIKFCD---RSDSGKYTLTVKNASGTKAVSVMVKVLD 29139
Score = 30.4 bits (67), Expect = 5.7
Identities = 53/234 (22%), Positives = 88/234 (37%), Gaps = 30/234 (12%)
Query: 58 SYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCV 117
S I + S + W+K+ ++ + V + S+ ++ E +D+ YTC
Sbjct: 5252 SSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLV-CHERSVSLEVNNLELEDTANYTCK 5310
Query: 118 LRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDV 177
+ N S LTV E S L R + + S V + K +
Sbjct: 5311 VSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTV---------EFKAILKGTPPFKI 5361
Query: 178 VWYKE-----CKPKMWRSIIIQKGNALL-IQEVQEEDGGNYTCELKYEGKLVRRTTELKV 231
W+K+ PK + I ++ + L + V G YTC + + TT L V
Sbjct: 5362 KWFKDDVELVSGPKCF--IGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLV 5419
Query: 232 TALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGE 285
T +PPK F + + S I V+ G + CK +G + W + E
Sbjct: 5420 T-----EPPK--FVKKLEASKI-VKAGDSSRLECK----IAGSPEIRVVWFRNE 5461
Score = 30.0 bits (66), Expect = 7.4
Identities = 25/98 (25%), Positives = 49/98 (50%), Gaps = 6/98 (6%)
Query: 167 DFKKSDQEPDVVWYK---ECKPKMWRSIIIQK-GNALLIQEVQEEDGGNYTCELKYEGKL 222
+ K S + + VW K E +P I+I K + LLI+++ +ED GNY+ + G
Sbjct: 2376 EVKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALG-- 2433
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKP 260
+ + + V ++ P K + +E +V++ ++ P
Sbjct: 2434 LSTSGRVSVYSVDVITPLKDVNVIEGTKAVLECKVSVP 2471
Score = 30.0 bits (66), Expect = 7.4
Identities = 18/49 (36%), Positives = 24/49 (48%), Gaps = 4/49 (8%)
Query: 199 LLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPME 247
L I+E D G YT ELK V TT + ++ DKP P P++
Sbjct: 29796 LTIRETTIRDTGEYTLELKN----VTGTTSETIKVIILDKPGPPTGPIK 29840
Score = 29.6 bits (65), Expect = 9.7
Identities = 36/163 (22%), Positives = 64/163 (39%), Gaps = 23/163 (14%)
Query: 188 WRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPME 247
++ +++ L + +V + D G YTC Y + + + +A L + P P F +
Sbjct: 7258 YKMTLVENTATLTVLKVGKGDAGQYTC---YASNIAGKDS---CSAQLGVQEP-PRFIKK 7310
Query: 248 NQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHL 307
+PS I V+ + CK G + W K E I+E + K +
Sbjct: 7311 LEPSRI-VKQDEFTRYECK----IGGSPEIKVLWYKDETEIQESS-----------KFRM 7354
Query: 308 GEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKKD 350
+ L ++ D +YTC N G +S L+ K+
Sbjct: 7355 SFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKE 7397
Score = 29.6 bits (65), Expect = 9.7
Identities = 35/138 (25%), Positives = 54/138 (39%), Gaps = 34/138 (24%)
Query: 134 AENESGLCYNSRIRYLEKSEVTKRKEISCPDMD---------------DFK-----KSDQ 173
AENE+G S I V R ++ PD+D +F+ K
Sbjct: 19957 AENENGEGTPSEIT------VVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKP 20010
Query: 174 EPDVVWYKECKPKMWRSIIIQKGNA----LLIQEVQEEDGGNYTCELKYEGKLVRRTTEL 229
P V W K P + + + +A L++ + Q+ D G YT LK V T E
Sbjct: 20011 APSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKN----VAGTKEG 20066
Query: 230 KVTALLTDKPPKPLFPME 247
++ + KP P P++
Sbjct: 20067 TISIKVVGKPGIPTGPIK 20084
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 53.5 bits (127), Expect = 6e-07
Identities = 65/265 (24%), Positives = 98/265 (36%), Gaps = 41/265 (15%)
Query: 76 WYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAE 135
WYK+ L + EV + ++ A DSG YTC N+ + + L+V
Sbjct: 1780 WYKDSQALS---LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1836
Query: 136 NESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKM--WRSIII 193
+ + V + +SC + EP V WYK+ +P + R+ +
Sbjct: 1837 PPAFRQAPRGPQDAVLVRVGDKAVLSCE-----TDALPEPTVTWYKDGQPLVLAQRTQAL 1891
Query: 194 QKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVI 253
+ G L IQE Q D G Y+C++ RT L V T + PK +
Sbjct: 1892 RGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPK--------TETV 1943
Query: 254 DVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGH---IREGEIRLLKEHLGEK 310
G PL + C SG P + W+K +E A H R G ++L +
Sbjct: 1944 SQVAGSPLVLTCDV----SGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSR------ 1993
Query: 311 EVELALIFDSVVEADLANYTCHVEN 335
+ A YTC EN
Sbjct: 1994 ----------LQPAQAGTYTCVAEN 2008
Score = 48.5 bits (114), Expect = 2e-05
Identities = 63/268 (23%), Positives = 96/268 (35%), Gaps = 53/268 (19%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAEN---ESGLCYNSRIRYLEKSEVTKRKEISC 162
A +D+G Y C+ +NS L V E+GL T+
Sbjct: 2816 ASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGL---------PDLSTTEGSHAFL 2866
Query: 163 PDMDDFKKSDQEPDVVWYKECKPKMWRS--IIIQKGNALLIQEVQEEDGGNYTCELKYEG 220
P + EP++ W K+ +P IQ LL++ ++ +D G YTC +
Sbjct: 2867 PCK---ARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2923
Query: 221 KLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIY 280
RR L + L P+F P ++LG L + C A G P I
Sbjct: 2924 GRARRRVHLTILVL-------PVF--TTLPGDRSLRLGDRLWLRCAA----RGSPTPRIG 2970
Query: 281 WMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRK 340
W + R + E + E++ L +V D Y C ENR GR
Sbjct: 2971 WTVND---------------RPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRT 3015
Query: 341 HA--------SVLLRKKDLIYKIELAGG 360
A + +L+ + Y +E GG
Sbjct: 3016 QAVSFVHVKEAPVLQGEAFSYLVEPVGG 3043
Score = 46.6 bits (109), Expect = 8e-05
Identities = 48/182 (26%), Positives = 75/182 (41%), Gaps = 29/182 (15%)
Query: 107 EAQDSGFYTCVLRNSTYCMK--VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPD 164
+ +D G YTC N K V++ + V N N + LE + VT
Sbjct: 665 DLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAV--LENASVT--------- 713
Query: 165 MDDFKKSDQEPDVVWYKECKP-KMWRSIIIQ-KGNALLIQEVQEEDGGNYTCELKYEGKL 222
++ PDV W+K +P W + + G L I++ Q D G+Y C
Sbjct: 714 LECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC----VASN 769
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPSVI-DVQLGKPLNIPCKAFFGFSGESGPMIYW 281
V +TEL+ L + PP+ P PS+ V + P+ + C A +G P + W
Sbjct: 770 VAGSTELRY-GLRVNVPPRITLP----PSLPGPVLVNTPVRLTCNA----TGAPSPTLMW 820
Query: 282 MK 283
+K
Sbjct: 821 LK 822
Score = 45.4 bits (106), Expect = 2e-04
Identities = 61/237 (25%), Positives = 82/237 (34%), Gaps = 36/237 (15%)
Query: 111 SGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKK 170
+G YTC RNS + LTV + S +R + + EV E S
Sbjct: 2731 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS--------- 2781
Query: 171 SDQEPDVVWYKE-CKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTEL 229
P + W KE S + G L I ED GNY C K + +
Sbjct: 2782 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSA-----GSAM 2836
Query: 230 KVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIE 289
T L+ PP +EN + G +PCKA G P I W K + +
Sbjct: 2837 GKTRLVVQVPP----VIENGLPDLSTTEGSHAFLPCKA----RGSPEPNITWDKDGQPVS 2888
Query: 290 ELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
G + + GE L+ ++ D YTC EN GR V L
Sbjct: 2889 GAEG-------KFTIQPSGE------LLVKNLEGQDAGTYTCTAENAVGRARRRVHL 2932
Score = 44.3 bits (103), Expect = 4e-04
Identities = 55/224 (24%), Positives = 90/224 (40%), Gaps = 33/224 (14%)
Query: 76 WYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNST------YCMKVSM 129
W K+ L + + +R + S+ A D+G YTCV N + + V +
Sbjct: 2060 WLKDGSPLGQDM-GPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV 2118
Query: 130 SLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPK--M 187
T+ + G S E+ + CP + V W K+ P
Sbjct: 2119 PPTIKQGADG----SGTLVSRPGELVT---MVCP-----VRGSPPIHVSWLKDGLPLPLS 2166
Query: 188 WRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPME 247
R+++ G+ L I +VQ D G +TC + R L+V + P L P+E
Sbjct: 2167 QRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLEPVE 2220
Query: 248 NQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK-GEKFIEE 290
Q V+ V+ G + +PC+A G P++ WMK GE + +
Sbjct: 2221 FQNDVVVVR-GSLVELPCEA----RGVPLPLVSWMKDGEPLLSQ 2259
Score = 43.9 bits (102), Expect = 5e-04
Identities = 46/192 (23%), Positives = 80/192 (41%), Gaps = 23/192 (11%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDM 165
A++ D+G YTC N+ + + L V + R Y+ K+ + + C
Sbjct: 372 AQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGR-PYVVKAVAGRPVALEC--- 427
Query: 166 DDFKKSDQEPDVVWYKECKP--KMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEG--K 221
+ P + W+ E P + S + G+ L ++ E G Y+C
Sbjct: 428 --VARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 485
Query: 222 LVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
+++ + E++V P L E V + +G+PL +PC+A SG P I W
Sbjct: 486 VLQYSVEVQV--------PPQLLVAEGLGQVTTI-VGQPLELPCQA----SGSPVPTIQW 532
Query: 282 MKGEKFIEELAG 293
++ + EELAG
Sbjct: 533 LQNGRPAEELAG 544
Score = 41.2 bits (95), Expect = 0.003
Identities = 33/131 (25%), Positives = 58/131 (44%), Gaps = 13/131 (9%)
Query: 175 PDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTAL 234
P V W K+ +P + +S+ ++G +L ++ V D G Y+C E RR +L V
Sbjct: 2245 PLVSWMKDGEPLLSQSL--EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM-- 2300
Query: 235 LTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGH 294
+PP QP+ + + G P+ + C A G P I W K + + L +
Sbjct: 2301 ---EPPH--IEDSGQPTELSLTPGAPMELLCDA----QGTPQPNITWHKDGQALTRLENN 2351
Query: 295 IREGEIRLLKE 305
R + +++
Sbjct: 2352 SRATRVLRVRD 2362
Score = 39.7 bits (91), Expect = 0.009
Identities = 72/307 (23%), Positives = 116/307 (37%), Gaps = 50/307 (16%)
Query: 44 LAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWF 103
L PVR+ C N + A S LMW K+ G+ P +++ +
Sbjct: 799 LVNTPVRLTC---------NATGAPSP--TLMWLKD-GNPVSPAGTPGLQVFPGGRVLTL 846
Query: 104 HSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCP 163
SA A DSG Y+CV ++ + + L V S L + + V + C
Sbjct: 847 ASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA----LECQ 902
Query: 164 DMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEE--DGGNYTCELKYEGK 221
+ P + W+K+ +P R + + L+Q + + D G+YTCE +
Sbjct: 903 -----SHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAG 957
Query: 222 LVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
+ L V P+FP+ + + V+ G P ++ C+ G P I W
Sbjct: 958 RSEKHYNLNVWV-------APVFPL-RESHTLTVREGHPTSLSCEC----RGVPFPKISW 1005
Query: 282 MK-GEKFIEELAGHIREGEI-RLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGR 339
K G+ E AG + RLL +LG+ ++ A YTC N G
Sbjct: 1006 RKDGQPLPGEGAGLQHVSAVGRLL--YLGQAQL-----------AQEGTYTCECSNVVGN 1052
Query: 340 KHASVLL 346
+ L
Sbjct: 1053 SSQDLQL 1059
Score = 39.7 bits (91), Expect = 0.009
Identities = 44/183 (24%), Positives = 71/183 (38%), Gaps = 28/183 (15%)
Query: 165 MDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGN-ALLIQEVQEEDGGNYTCELKYEGKLV 223
+D + D PD+ W K+ P + Q N +L I + +D G Y C + E +
Sbjct: 3047 LDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVA 3106
Query: 224 RRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
++ L + + P+F +E P + V+ G + + C+A +GE P I W++
Sbjct: 3107 KKVVILVLQS-------APVFQVE--PQDMTVRSGDDVALRCQA----TGEPTPTIEWLQ 3153
Query: 284 GEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHAS 343
AG RL G +L ++V D Y C N G A
Sbjct: 3154 --------AGQPLRASRRLRTLPDG------SLWLENVETGDAGTYDCVAHNLLGSATAR 3199
Query: 344 VLL 346
L
Sbjct: 3200 AFL 3202
Score = 38.1 bits (87), Expect = 0.027
Identities = 25/109 (22%), Positives = 42/109 (38%), Gaps = 12/109 (11%)
Query: 175 PDVVWYKE--CKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVT 232
P++ W+K+ P + + + G L + Q D G YTC+ + T L V
Sbjct: 341 PNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 400
Query: 233 ALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
P + +P V+ G+P+ + C A G P + W
Sbjct: 401 V------PPTIEGAGGRPYVVKAVAGRPVALECVA----RGHPSPTLSW 439
Score = 38.1 bits (87), Expect = 0.027
Identities = 45/177 (25%), Positives = 66/177 (37%), Gaps = 28/177 (15%)
Query: 175 PDVVWYKECKPKMWRS--IIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVT 232
PD+ WY+E +P ++Q G L I V+ E+ G Y+C+ E EL V
Sbjct: 1589 PDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL 1648
Query: 233 ALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK-GEKFIEEL 291
PP L E + V +++ C A G P I W++ G F
Sbjct: 1649 T-----PPVILGDTEELVEEVTVNASSTVSLQCPAL----GNPVPTISWLQNGLPFSPSP 1699
Query: 292 AGHIRE-GEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLR 347
+ E G++ L + AD A+Y C EN+ G LR
Sbjct: 1700 RLQVLEDGQV---------------LQVSTAEVADAASYMCVAENQAGSAEKLFTLR 1741
Score = 35.8 bits (81), Expect = 0.14
Identities = 29/119 (24%), Positives = 54/119 (45%), Gaps = 18/119 (15%)
Query: 105 SAEAQDSGFYTCVLRN------STYCMKVSMSLTVAENESGLCYNSRIRYLE-KSEVTKR 157
+A+ +D+G YTCV+ N Y ++V + ++++++ + E K++V
Sbjct: 1410 NAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDP----LGEVGVKEVKTKVNST 1465
Query: 158 KEISCPDMDDFKKSDQEPDVVWYKECKP--KMWRSIIIQKGNALLIQEVQEEDGGNYTC 214
+ C + P + WYK+ +P R ++ +G L IQ Q D G Y C
Sbjct: 1466 LTLECESW-----AVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 1519
Score = 33.5 bits (75), Expect = 0.67
Identities = 30/137 (21%), Positives = 54/137 (39%), Gaps = 24/137 (17%)
Query: 86 PIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSR 145
P+ S +R + S+ H E D+G Y C +AENE G+
Sbjct: 3067 PLRGSHLRHQLQNGSLTIHRTERDDAGRYQC----------------LAENEMGVAKKVV 3110
Query: 146 IRYLEKSEV--TKRKEISCPDMDDF-----KKSDQEPDVVWYKECKP-KMWRSIIIQKGN 197
I L+ + V + ++++ DD + P + W + +P + R +
Sbjct: 3111 ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG 3170
Query: 198 ALLIQEVQEEDGGNYTC 214
+L ++ V+ D G Y C
Sbjct: 3171 SLWLENVETGDAGTYDC 3187
Score = 32.7 bits (73), Expect = 1.1
Identities = 53/254 (20%), Positives = 94/254 (37%), Gaps = 38/254 (14%)
Query: 92 VRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVA---ENESGLCYNSRIRY 148
+++ + S+ A+A +G Y+CV N + L+V E L + I
Sbjct: 1114 LQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITA 1173
Query: 149 LEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKM--WRSIIIQKGNALLIQEVQE 206
S +T + C M P + W++ +P + ++ G L + + QE
Sbjct: 1174 ALHSPLT----LLCEAM-----GIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQE 1224
Query: 207 EDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCK 266
+D G Y+C E RR ++V P E+ VI V G+ ++ C
Sbjct: 1225 QDSGLYSCLASNEAGEARRNFSVEVLV-------PPSIENEDLEEVIKVLDGQTAHLMCN 1277
Query: 267 AFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADL 326
+G P + W K + + H H+ V L ++ ++ A
Sbjct: 1278 V----TGHPQPKLTWFKDGRPLARGDAH-----------HISPDGVLLQVLQANLSSA-- 1320
Query: 327 ANYTCHVENRNGRK 340
+Y+C N G K
Sbjct: 1321 GHYSCIAANAVGEK 1334
Score = 32.3 bits (72), Expect = 1.5
Identities = 55/247 (22%), Positives = 91/247 (36%), Gaps = 36/247 (14%)
Query: 107 EAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMD 166
+ QDSG Y+C+ N + + S+ V S I + EV K + +
Sbjct: 1223 QEQDSGLYSCLASNEAGEARRNFSVEVLVPPS-------IENEDLEEVIKVLDGQTAHLM 1275
Query: 167 DFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQE--EDGGNYTCELKYEGKLVR 224
+P + W+K+ +P + +L+Q +Q G+Y+C +
Sbjct: 1276 CNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIA--ANAVGE 1333
Query: 225 RTTELKVTALLTDKPPKPLFPMENQ-PSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
+T +++ LL P L E+ + V + P+++ C+A P I WMK
Sbjct: 1334 KTKHFQLSVLLA---PTILGGAEDSADEEVTVTVNNPISLICEAL----AFPSPNITWMK 1386
Query: 284 GEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRK--- 340
E I+LL G L + + D YTC V N G
Sbjct: 1387 DGAPFE------ASRNIQLLPGTHG-------LQILNAQKEDAGQYTCVVTNELGEAVKN 1433
Query: 341 -HASVLL 346
H VL+
Sbjct: 1434 YHVEVLI 1440
Score = 31.6 bits (70), Expect = 2.6
Identities = 31/178 (17%), Positives = 66/178 (37%), Gaps = 42/178 (23%)
Query: 170 KSDQEPDVVWYKECKPKMWRSIIIQ---------KGNALLIQEVQEEDGGNYTCELKYEG 220
+++ P + W+++ I++Q +G L +Q + D G+Y+C +
Sbjct: 2415 EAEPAPKITWHRD-------GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA 2467
Query: 221 KLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIY 280
+++ + T + + P ++V + + +PC+A G P++
Sbjct: 2468 GSTSVAFRVEIHTVPT---------IRSGPPAVNVSVNQTALLPCQA----DGVPAPLVS 2514
Query: 281 WMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNG 338
W K ++ R +L E +L V+ D +Y C N G
Sbjct: 2515 WRKDRVPLDP-----RSPRFEILPEG--------SLRIQPVLAQDAGHYLCLASNSAG 2559
Score = 31.6 bits (70), Expect = 2.6
Identities = 55/256 (21%), Positives = 87/256 (33%), Gaps = 45/256 (17%)
Query: 98 EDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKR 157
E S+ AQD+G Y C+ NS + L V E + S + +
Sbjct: 2534 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLP 2593
Query: 158 KEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKG-------NALLIQEVQEEDGG 210
E S +P VVW+K+ + +R +Q+G NALL+ +D
Sbjct: 2594 CEAS---------GSPKPLVVWWKDGQKLDFR---LQQGAYRLLPSNALLLTAPGPQDSA 2641
Query: 211 NYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFG 270
+ C + E R ++ V PP + + + V + P+ + C +
Sbjct: 2642 QFECVVSNEVGEAHRLYQVTVHV-----PP----TIADDQTDFTVTMMAPVVLTCHS--- 2689
Query: 271 FSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYT 330
+G P + W K + R G E+ AL + YT
Sbjct: 2690 -TGIPAPTVSWSKAGAQLGARGSGYRVSP-------SGALEIGQALPIHA------GRYT 2735
Query: 331 CHVENRNGRKHASVLL 346
C N G H V L
Sbjct: 2736 CSARNSAGVAHKHVFL 2751
Score = 30.8 bits (68), Expect = 4.4
Identities = 52/258 (20%), Positives = 99/258 (38%), Gaps = 47/258 (18%)
Query: 85 EPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAE----NESGL 140
EP++ + ++ S+ + A DSG Y+CV + + LTV E +SG
Sbjct: 2254 EPLLSQSL---EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG- 2309
Query: 141 CYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALL 200
+ +E++ + D + + Q P++ W+K+ +++ + N+
Sbjct: 2310 ---------QPTELSLTPGAPMELLCDAQGTPQ-PNITWHKD-----GQALTRLENNSRA 2354
Query: 201 IQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKP 260
+ ++ D G YTC + + ++ ++V A PP + P V+ + G+
Sbjct: 2355 TRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA-----PPNIVGP-RGPRFVVGLAPGQ- 2407
Query: 261 LNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDS 320
L + C E P I W R+G + H E L +
Sbjct: 2408 LVLECSV----EAEPAPKITWH-------------RDGIVLQEDAHTQFPERGRFLQLQA 2450
Query: 321 VVEADLANYTCHVENRNG 338
+ AD +Y+C N G
Sbjct: 2451 LSTADSGDYSCTARNAAG 2468
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 53.5 bits (127), Expect = 6e-07
Identities = 65/265 (24%), Positives = 98/265 (36%), Gaps = 41/265 (15%)
Query: 76 WYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAE 135
WYK+ L + EV + ++ A DSG YTC N+ + + L+V
Sbjct: 2971 WYKDSQALS---LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 3027
Query: 136 NESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKM--WRSIII 193
+ + V + +SC + EP V WYK+ +P + R+ +
Sbjct: 3028 PPAFRQAPRGPQDAVLVRVGDKAVLSCE-----TDALPEPTVTWYKDGQPLVLAQRTQAL 3082
Query: 194 QKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVI 253
+ G L IQE Q D G Y+C++ RT L V T + PK +
Sbjct: 3083 RGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPK--------TETV 3134
Query: 254 DVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGH---IREGEIRLLKEHLGEK 310
G PL + C SG P + W+K +E A H R G ++L +
Sbjct: 3135 SQVAGSPLVLTCDV----SGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSR------ 3184
Query: 311 EVELALIFDSVVEADLANYTCHVEN 335
+ A YTC EN
Sbjct: 3185 ----------LQPAQAGTYTCVAEN 3199
Score = 50.8 bits (120), Expect = 4e-06
Identities = 58/238 (24%), Positives = 89/238 (37%), Gaps = 39/238 (16%)
Query: 110 DSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFK 169
D G Y CV N+ + S+ L V E + S + + EV ++SC
Sbjct: 581 DGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEV----KVSCS-----A 631
Query: 170 KSDQEPDVVWYKECKPKMWRSII-IQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTE 228
P + W +E + S I + L+IQ V ED GNY+C+ E T +
Sbjct: 632 SGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNE----VGTDQ 687
Query: 229 LKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFI 288
VT TD P + +V+ V +G+ + C+A SG P + W +G +
Sbjct: 688 ETVTLYYTDPP-----SVSAVNAVVLVAVGEEAVLVCEA----SGVPPPRVIWYRGGLEM 738
Query: 289 EELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
G++R+ + E D YTC N G A + L
Sbjct: 739 ILAPEGSSSGKLRI----------------PAAQERDAGTYTCRAVNELGDASAEIQL 780
Score = 48.5 bits (114), Expect = 2e-05
Identities = 63/268 (23%), Positives = 96/268 (35%), Gaps = 53/268 (19%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAEN---ESGLCYNSRIRYLEKSEVTKRKEISC 162
A +D+G Y C+ +NS L V E+GL T+
Sbjct: 4007 ASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGL---------PDLSTTEGSHAFL 4057
Query: 163 PDMDDFKKSDQEPDVVWYKECKPKMWRS--IIIQKGNALLIQEVQEEDGGNYTCELKYEG 220
P + EP++ W K+ +P IQ LL++ ++ +D G YTC +
Sbjct: 4058 PCK---ARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 4114
Query: 221 KLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIY 280
RR L + L P+F P ++LG L + C A G P I
Sbjct: 4115 GRARRRVHLTILVL-------PVF--TTLPGDRSLRLGDRLWLRCAA----RGSPTPRIG 4161
Query: 281 WMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRK 340
W + R + E + E++ L +V D Y C ENR GR
Sbjct: 4162 WTVND---------------RPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRT 4206
Query: 341 HA--------SVLLRKKDLIYKIELAGG 360
A + +L+ + Y +E GG
Sbjct: 4207 QAVSFVHVKEAPVLQGEAFSYLVEPVGG 4234
Score = 46.6 bits (109), Expect = 8e-05
Identities = 48/182 (26%), Positives = 75/182 (41%), Gaps = 29/182 (15%)
Query: 107 EAQDSGFYTCVLRNSTYCMK--VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPD 164
+ +D G YTC N K V++ + V N N + LE + VT
Sbjct: 1856 DLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAV--LENASVT--------- 1904
Query: 165 MDDFKKSDQEPDVVWYKECKP-KMWRSIIIQ-KGNALLIQEVQEEDGGNYTCELKYEGKL 222
++ PDV W+K +P W + + G L I++ Q D G+Y C
Sbjct: 1905 LECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC----VASN 1960
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPSVI-DVQLGKPLNIPCKAFFGFSGESGPMIYW 281
V +TEL+ L + PP+ P PS+ V + P+ + C A +G P + W
Sbjct: 1961 VAGSTELRY-GLRVNVPPRITLP----PSLPGPVLVNTPVRLTCNA----TGAPSPTLMW 2011
Query: 282 MK 283
+K
Sbjct: 2012 LK 2013
Score = 45.4 bits (106), Expect = 2e-04
Identities = 61/237 (25%), Positives = 82/237 (34%), Gaps = 36/237 (15%)
Query: 111 SGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKK 170
+G YTC RNS + LTV + S +R + + EV E S
Sbjct: 3922 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS--------- 3972
Query: 171 SDQEPDVVWYKE-CKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTEL 229
P + W KE S + G L I ED GNY C K + +
Sbjct: 3973 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSA-----GSAM 4027
Query: 230 KVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIE 289
T L+ PP +EN + G +PCKA G P I W K + +
Sbjct: 4028 GKTRLVVQVPP----VIENGLPDLSTTEGSHAFLPCKA----RGSPEPNITWDKDGQPVS 4079
Query: 290 ELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
G + + GE L+ ++ D YTC EN GR V L
Sbjct: 4080 GAEG-------KFTIQPSGE------LLVKNLEGQDAGTYTCTAENAVGRARRRVHL 4123
Score = 44.3 bits (103), Expect = 4e-04
Identities = 55/224 (24%), Positives = 90/224 (40%), Gaps = 33/224 (14%)
Query: 76 WYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNST------YCMKVSM 129
W K+ L + + +R + S+ A D+G YTCV N + + V +
Sbjct: 3251 WLKDGSPLGQDM-GPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV 3309
Query: 130 SLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPK--M 187
T+ + G S E+ + CP + V W K+ P
Sbjct: 3310 PPTIKQGADG----SGTLVSRPGELVT---MVCP-----VRGSPPIHVSWLKDGLPLPLS 3357
Query: 188 WRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPME 247
R+++ G+ L I +VQ D G +TC + R L+V + P L P+E
Sbjct: 3358 QRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLEPVE 3411
Query: 248 NQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK-GEKFIEE 290
Q V+ V+ G + +PC+A G P++ WMK GE + +
Sbjct: 3412 FQNDVVVVR-GSLVELPCEA----RGVPLPLVSWMKDGEPLLSQ 3450
Score = 43.9 bits (102), Expect = 5e-04
Identities = 46/192 (23%), Positives = 80/192 (41%), Gaps = 23/192 (11%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDM 165
A++ D+G YTC N+ + + L V + R Y+ K+ + + C
Sbjct: 1563 AQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGR-PYVVKAVAGRPVALEC--- 1618
Query: 166 DDFKKSDQEPDVVWYKECKP--KMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEG--K 221
+ P + W+ E P + S + G+ L ++ E G Y+C
Sbjct: 1619 --VARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 1676
Query: 222 LVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
+++ + E++V P L E V + +G+PL +PC+A SG P I W
Sbjct: 1677 VLQYSVEVQV--------PPQLLVAEGLGQVTTI-VGQPLELPCQA----SGSPVPTIQW 1723
Query: 282 MKGEKFIEELAG 293
++ + EELAG
Sbjct: 1724 LQNGRPAEELAG 1735
Score = 43.5 bits (101), Expect = 6e-04
Identities = 58/241 (24%), Positives = 94/241 (39%), Gaps = 36/241 (14%)
Query: 109 QDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDF 168
+D+G Y+C N + +++L + S N+ + E E S
Sbjct: 670 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS------- 722
Query: 169 KKSDQEPDVVWYKECKPKMWRSIIIQKGNA---LLIQEVQEEDGGNYTCELKYEGKLVRR 225
P V+WY+ I+ +G++ L I QE D G YTC E L
Sbjct: 723 --GVPPPRVIWYRGGL----EMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNE--LGDA 774
Query: 226 TTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGE 285
+ E++ L P+ + P + V+LG+ + C+A +G P + W +G+
Sbjct: 775 SAEIQ---LAVGHAPQ----LTELPRDVTVELGRSALLACRA----TGRPPPTVTWRRGD 823
Query: 286 KFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVL 345
+ L +R G R + + V L F+SV D A Y C N G+ A
Sbjct: 824 G--QPLG--LRLGAGRGSRSRQPDSGV---LFFESVAPEDQAPYVCEARNVFGKVQAEAR 876
Query: 346 L 346
L
Sbjct: 877 L 877
Score = 41.2 bits (95), Expect = 0.003
Identities = 33/131 (25%), Positives = 58/131 (44%), Gaps = 13/131 (9%)
Query: 175 PDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTAL 234
P V W K+ +P + +S+ ++G +L ++ V D G Y+C E RR +L V
Sbjct: 3436 PLVSWMKDGEPLLSQSL--EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM-- 3491
Query: 235 LTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGH 294
+PP QP+ + + G P+ + C A G P I W K + + L +
Sbjct: 3492 ---EPPH--IEDSGQPTELSLTPGAPMELLCDA----QGTPQPNITWHKDGQALTRLENN 3542
Query: 295 IREGEIRLLKE 305
R + +++
Sbjct: 3543 SRATRVLRVRD 3553
Score = 40.8 bits (94), Expect = 0.004
Identities = 58/260 (22%), Positives = 94/260 (36%), Gaps = 51/260 (19%)
Query: 98 EDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTV-------AENESGLCYNSRIRYLE 150
+ S+ F + D+G Y C NS + L V A+ SGL LE
Sbjct: 1166 QGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGL--------LE 1217
Query: 151 KSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRS---IIIQKGNALLIQEVQEE 207
+ + + CP + +P V W K + + + + +L + V
Sbjct: 1218 RV-AGENASLPCP-----ARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPA 1271
Query: 208 DGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKA 267
D G+Y C+ E R +L V P + + + + G+ L + C A
Sbjct: 1272 DSGDYECQATNEVGSTSRRAKLVVYV-------PPSIREDGRKANVSGMAGQSLTLECDA 1324
Query: 268 FFGFSGESGPMIYWMKGEKFIEELAGHI---------REGEIRLLKEHLGEKEVELALIF 318
+G P I W+K + + G + G RLL E G+ +L F
Sbjct: 1325 ----NGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE--GQ-----SLHF 1373
Query: 319 DSVVEADLANYTCHVENRNG 338
+ E D Y+C EN+ G
Sbjct: 1374 PRIQEGDSGLYSCRAENQAG 1393
Score = 39.7 bits (91), Expect = 0.009
Identities = 44/183 (24%), Positives = 71/183 (38%), Gaps = 28/183 (15%)
Query: 165 MDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGN-ALLIQEVQEEDGGNYTCELKYEGKLV 223
+D + D PD+ W K+ P + Q N +L I + +D G Y C + E +
Sbjct: 4238 LDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVA 4297
Query: 224 RRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
++ L + + P+F +E P + V+ G + + C+A +GE P I W++
Sbjct: 4298 KKVVILVLQS-------APVFQVE--PQDMTVRSGDDVALRCQA----TGEPTPTIEWLQ 4344
Query: 284 GEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHAS 343
AG RL G +L ++V D Y C N G A
Sbjct: 4345 --------AGQPLRASRRLRTLPDG------SLWLENVETGDAGTYDCVAHNLLGSATAR 4390
Query: 344 VLL 346
L
Sbjct: 4391 AFL 4393
Score = 39.3 bits (90), Expect = 0.012
Identities = 72/307 (23%), Positives = 116/307 (37%), Gaps = 50/307 (16%)
Query: 44 LAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWF 103
L PVR+ C N + A S LMW K+ G+ P +++ +
Sbjct: 1990 LVNTPVRLTC---------NATGAPSP--TLMWLKD-GNPVSPAGTPGLQVFPGGRVLTL 2037
Query: 104 HSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCP 163
SA A DSG Y+CV ++ + + L V S L + + V + C
Sbjct: 2038 ASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA----LECQ 2093
Query: 164 DMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEE--DGGNYTCELKYEGK 221
+ P + W+K+ +P R + + L+Q + + D G+YTCE +
Sbjct: 2094 -----SHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAG 2148
Query: 222 LVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
+ L V P+FP+ + + V+ G P ++ C+ G P I W
Sbjct: 2149 HSEKHYNLNVWV-------APVFPL-RESHTLTVREGHPTSLSCEC----RGVPFPKISW 2196
Query: 282 MK-GEKFIEELAGHIREGEI-RLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGR 339
K G+ E AG + RLL +LG+ ++ A YTC N G
Sbjct: 2197 RKDGQPLPGEGAGLQHVSAVGRLL--YLGQAQL-----------AQEGTYTCECSNVVGN 2243
Query: 340 KHASVLL 346
+ L
Sbjct: 2244 SSQDLQL 2250
Score = 38.1 bits (87), Expect = 0.027
Identities = 39/165 (23%), Positives = 66/165 (40%), Gaps = 33/165 (20%)
Query: 193 IQKGNALLIQEVQEEDGGNYTCEL---------KYEGKLVRR--TTELKVTALLTDKPPK 241
+++G A L +E ++ GN + E+ YE V R T K ++TD PP+
Sbjct: 460 LRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQ 519
Query: 242 PLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIR 301
L P N + V G+ + C+ GE+ + W++ + + G + +
Sbjct: 520 -LVPAPN----VTVSPGETAVLSCRVL----GEAPYNLTWVRDWRVLPASTGRVAQ---- 566
Query: 302 LLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
+L+L ++ D Y C N NG ASV L
Sbjct: 567 ---------LADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 602
Score = 38.1 bits (87), Expect = 0.027
Identities = 25/109 (22%), Positives = 42/109 (38%), Gaps = 12/109 (11%)
Query: 175 PDVVWYKE--CKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVT 232
P++ W+K+ P + + + G L + Q D G YTC+ + T L V
Sbjct: 1532 PNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 1591
Query: 233 ALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
P + +P V+ G+P+ + C A G P + W
Sbjct: 1592 V------PPTIEGAGGRPYVVKAVAGRPVALECVA----RGHPSPTLSW 1630
Score = 38.1 bits (87), Expect = 0.027
Identities = 45/177 (25%), Positives = 66/177 (37%), Gaps = 28/177 (15%)
Query: 175 PDVVWYKECKPKMWRS--IIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVT 232
PD+ WY+E +P ++Q G L I V+ E+ G Y+C+ E EL V
Sbjct: 2780 PDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL 2839
Query: 233 ALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK-GEKFIEEL 291
PP L E + V +++ C A G P I W++ G F
Sbjct: 2840 T-----PPVILGDTEELVEEVTVNASSTVSLQCPAL----GNPVPTISWLQNGLPFSPSP 2890
Query: 292 AGHIRE-GEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLR 347
+ E G++ L + AD A+Y C EN+ G LR
Sbjct: 2891 RLQVLEDGQV---------------LQVSTAEVADAASYMCVAENQAGSAEKLFTLR 2932
Score = 35.8 bits (81), Expect = 0.14
Identities = 29/119 (24%), Positives = 54/119 (45%), Gaps = 18/119 (15%)
Query: 105 SAEAQDSGFYTCVLRN------STYCMKVSMSLTVAENESGLCYNSRIRYLE-KSEVTKR 157
+A+ +D+G YTCV+ N Y ++V + ++++++ + E K++V
Sbjct: 2601 NAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDP----LGEVGVKEVKTKVNST 2656
Query: 158 KEISCPDMDDFKKSDQEPDVVWYKECKP--KMWRSIIIQKGNALLIQEVQEEDGGNYTC 214
+ C + P + WYK+ +P R ++ +G L IQ Q D G Y C
Sbjct: 2657 LTLECESW-----AVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 2710
Score = 35.4 bits (80), Expect = 0.18
Identities = 57/256 (22%), Positives = 93/256 (36%), Gaps = 47/256 (18%)
Query: 80 KGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTV----AE 135
KG EP+ EE S++ S DSG Y C N L V +
Sbjct: 1242 KGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSI 1301
Query: 136 NESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECK----PKMWRSI 191
E G N + + +T + C D + F P++VW K+ + P W
Sbjct: 1302 REDGRKAN--VSGMAGQSLT----LEC-DANGFPV----PEIVWLKDAQLVGVPLGWAGY 1350
Query: 192 -------------IIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDK 238
++ +G +L +QE D G Y+C + + +R L V
Sbjct: 1351 GWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLT----- 1405
Query: 239 PPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREG 298
PP L Q V+ + G + + C SG P + W K + + H++
Sbjct: 1406 PPSVLGAGAAQ-EVLGL-AGADVELQCWT----SGVPTPQVEWTKDRQPVLPGGPHLQVQ 1459
Query: 299 E----IRLLKEHLGEK 310
E +R+ H+G++
Sbjct: 1460 EDGQVLRITGSHVGDE 1475
Score = 33.5 bits (75), Expect = 0.67
Identities = 30/137 (21%), Positives = 54/137 (39%), Gaps = 24/137 (17%)
Query: 86 PIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSR 145
P+ S +R + S+ H E D+G Y C +AENE G+
Sbjct: 4258 PLRGSHLRHQLQNGSLTIHRTERDDAGRYQC----------------LAENEMGVAKKVV 4301
Query: 146 IRYLEKSEV--TKRKEISCPDMDDF-----KKSDQEPDVVWYKECKP-KMWRSIIIQKGN 197
I L+ + V + ++++ DD + P + W + +P + R +
Sbjct: 4302 ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG 4361
Query: 198 ALLIQEVQEEDGGNYTC 214
+L ++ V+ D G Y C
Sbjct: 4362 SLWLENVETGDAGTYDC 4378
Score = 32.7 bits (73), Expect = 1.1
Identities = 53/254 (20%), Positives = 94/254 (37%), Gaps = 38/254 (14%)
Query: 92 VRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVA---ENESGLCYNSRIRY 148
+++ + S+ A+A +G Y+CV N + L+V E L + I
Sbjct: 2305 LQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITA 2364
Query: 149 LEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKM--WRSIIIQKGNALLIQEVQE 206
S +T + C M P + W++ +P + ++ G L + + QE
Sbjct: 2365 ALHSPLT----LLCEAM-----GIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQE 2415
Query: 207 EDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCK 266
+D G Y+C E RR ++V P E+ VI V G+ ++ C
Sbjct: 2416 QDSGLYSCLASNEAGEARRNFSVEVLV-------PPSIENEDLEEVIKVLDGQTAHLMCN 2468
Query: 267 AFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADL 326
+G P + W K + + H H+ V L ++ ++ A
Sbjct: 2469 V----TGHPQPKLTWFKDGRPLARGDAH-----------HISPDGVLLQVLQANLSSA-- 2511
Query: 327 ANYTCHVENRNGRK 340
+Y+C N G K
Sbjct: 2512 GHYSCIAANAVGEK 2525
Score = 32.3 bits (72), Expect = 1.5
Identities = 55/247 (22%), Positives = 91/247 (36%), Gaps = 36/247 (14%)
Query: 107 EAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMD 166
+ QDSG Y+C+ N + + S+ V S I + EV K + +
Sbjct: 2414 QEQDSGLYSCLASNEAGEARRNFSVEVLVPPS-------IENEDLEEVIKVLDGQTAHLM 2466
Query: 167 DFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQE--EDGGNYTCELKYEGKLVR 224
+P + W+K+ +P + +L+Q +Q G+Y+C +
Sbjct: 2467 CNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIA--ANAVGE 2524
Query: 225 RTTELKVTALLTDKPPKPLFPMENQ-PSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
+T +++ LL P L E+ + V + P+++ C+A P I WMK
Sbjct: 2525 KTKHFQLSVLLA---PTILGGAEDSADEEVTVTVNNPISLICEAL----AFPSPNITWMK 2577
Query: 284 GEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRK--- 340
E I+LL G L + + D YTC V N G
Sbjct: 2578 DGAPFE------ASRNIQLLPGTHG-------LQILNAQKEDAGQYTCVVTNELGEAVKN 2624
Query: 341 -HASVLL 346
H VL+
Sbjct: 2625 YHVEVLI 2631
Score = 31.6 bits (70), Expect = 2.6
Identities = 31/178 (17%), Positives = 66/178 (37%), Gaps = 42/178 (23%)
Query: 170 KSDQEPDVVWYKECKPKMWRSIIIQ---------KGNALLIQEVQEEDGGNYTCELKYEG 220
+++ P + W+++ I++Q +G L +Q + D G+Y+C +
Sbjct: 3606 EAEPAPKITWHRD-------GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA 3658
Query: 221 KLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIY 280
+++ + T + + P ++V + + +PC+A G P++
Sbjct: 3659 GSTSVAFRVEIHTVPT---------IRSGPPAVNVSVNQTALLPCQA----DGVPAPLVS 3705
Query: 281 WMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNG 338
W K ++ R +L E +L V+ D +Y C N G
Sbjct: 3706 WRKDRVPLDP-----RSPRFEILPEG--------SLRIQPVLAQDAGHYLCLASNSAG 3750
Score = 31.6 bits (70), Expect = 2.6
Identities = 55/256 (21%), Positives = 87/256 (33%), Gaps = 45/256 (17%)
Query: 98 EDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKR 157
E S+ AQD+G Y C+ NS + L V E + S + +
Sbjct: 3725 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLP 3784
Query: 158 KEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKG-------NALLIQEVQEEDGG 210
E S +P VVW+K+ + +R +Q+G NALL+ +D
Sbjct: 3785 CEAS---------GSPKPLVVWWKDGQKLDFR---LQQGAYRLLPSNALLLTAPGPQDSA 3832
Query: 211 NYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFG 270
+ C + E R ++ V PP + + + V + P+ + C +
Sbjct: 3833 QFECVVSNEVGEAHRLYQVTVHV-----PP----TIADDQTDFTVTMMAPVVLTCHS--- 3880
Query: 271 FSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYT 330
+G P + W K + R G E+ AL + YT
Sbjct: 3881 -TGIPAPTVSWSKAGAQLGARGSGYRVSP-------SGALEIGQALPIHA------GRYT 3926
Query: 331 CHVENRNGRKHASVLL 346
C N G H V L
Sbjct: 3927 CSARNSAGVAHKHVFL 3942
Score = 30.8 bits (68), Expect = 4.4
Identities = 52/258 (20%), Positives = 99/258 (38%), Gaps = 47/258 (18%)
Query: 85 EPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAE----NESGL 140
EP++ + ++ S+ + A DSG Y+CV + + LTV E +SG
Sbjct: 3445 EPLLSQSL---EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG- 3500
Query: 141 CYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALL 200
+ +E++ + D + + Q P++ W+K+ +++ + N+
Sbjct: 3501 ---------QPTELSLTPGAPMELLCDAQGTPQ-PNITWHKD-----GQALTRLENNSRA 3545
Query: 201 IQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKP 260
+ ++ D G YTC + + ++ ++V A PP + P V+ + G+
Sbjct: 3546 TRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA-----PPNIVGP-RGPRFVVGLAPGQ- 3598
Query: 261 LNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDS 320
L + C E P I W R+G + H E L +
Sbjct: 3599 LVLECSV----EAEPAPKITWH-------------RDGIVLQEDAHTQFPERGRFLQLQA 3641
Query: 321 VVEADLANYTCHVENRNG 338
+ AD +Y+C N G
Sbjct: 3642 LSTADSGDYSCTARNAAG 3659
Score = 30.4 bits (67), Expect = 5.7
Identities = 34/161 (21%), Positives = 56/161 (34%), Gaps = 32/161 (19%)
Query: 187 MWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPM 246
+W + +L + +VQ D G+Y C L V PP+ +
Sbjct: 1072 VWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQV-----PPQ----V 1122
Query: 247 ENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEH 306
+ P V+ V +G+ L++ C A G P + W K ++ G +G +
Sbjct: 1123 QPGPRVLKVLVGEALDLNCVA----EGNPEPQLSWSKDGVVLQ---GRGPQGSVH----- 1170
Query: 307 LGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLR 347
F ++ +D Y C N G V LR
Sbjct: 1171 -----------FAAIRTSDAGRYRCEASNSAGVDAWEVELR 1200
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 53.5 bits (127), Expect = 6e-07
Identities = 65/265 (24%), Positives = 98/265 (36%), Gaps = 41/265 (15%)
Query: 76 WYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAE 135
WYK+ L + EV + ++ A DSG YTC N+ + + L+V
Sbjct: 1689 WYKDSQALS---LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV 1745
Query: 136 NESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKM--WRSIII 193
+ + V + +SC + EP V WYK+ +P + R+ +
Sbjct: 1746 PPAFRQAPRGPQDAVLVRVGDKAVLSCE-----TDALPEPTVTWYKDGQPLVLAQRTQAL 1800
Query: 194 QKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVI 253
+ G L IQE Q D G Y+C++ RT L V T + PK +
Sbjct: 1801 RGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPK--------TETV 1852
Query: 254 DVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGH---IREGEIRLLKEHLGEK 310
G PL + C SG P + W+K +E A H R G ++L +
Sbjct: 1853 SQVAGSPLVLTCDV----SGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSR------ 1902
Query: 311 EVELALIFDSVVEADLANYTCHVEN 335
+ A YTC EN
Sbjct: 1903 ----------LQPAQAGTYTCVAEN 1917
Score = 48.5 bits (114), Expect = 2e-05
Identities = 63/268 (23%), Positives = 96/268 (35%), Gaps = 53/268 (19%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAEN---ESGLCYNSRIRYLEKSEVTKRKEISC 162
A +D+G Y C+ +NS L V E+GL T+
Sbjct: 2725 ASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGL---------PDLSTTEGSHAFL 2775
Query: 163 PDMDDFKKSDQEPDVVWYKECKPKMWRS--IIIQKGNALLIQEVQEEDGGNYTCELKYEG 220
P + EP++ W K+ +P IQ LL++ ++ +D G YTC +
Sbjct: 2776 PCK---ARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2832
Query: 221 KLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIY 280
RR L + L P+F P ++LG L + C A G P I
Sbjct: 2833 GRARRRVHLTILVL-------PVF--TTLPGDRSLRLGDRLWLRCAA----RGSPTPRIG 2879
Query: 281 WMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRK 340
W + R + E + E++ L +V D Y C ENR GR
Sbjct: 2880 WTVND---------------RPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRT 2924
Query: 341 HA--------SVLLRKKDLIYKIELAGG 360
A + +L+ + Y +E GG
Sbjct: 2925 QAVSFVHVKEAPVLQGEAFSYLVEPVGG 2952
Score = 46.6 bits (109), Expect = 8e-05
Identities = 48/182 (26%), Positives = 75/182 (41%), Gaps = 29/182 (15%)
Query: 107 EAQDSGFYTCVLRNSTYCMK--VSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPD 164
+ +D G YTC N K V++ + V N N + LE + VT
Sbjct: 574 DLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAV--LENASVT--------- 622
Query: 165 MDDFKKSDQEPDVVWYKECKP-KMWRSIIIQ-KGNALLIQEVQEEDGGNYTCELKYEGKL 222
++ PDV W+K +P W + + G L I++ Q D G+Y C
Sbjct: 623 LECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRC----VASN 678
Query: 223 VRRTTELKVTALLTDKPPKPLFPMENQPSVI-DVQLGKPLNIPCKAFFGFSGESGPMIYW 281
V +TEL+ L + PP+ P PS+ V + P+ + C A +G P + W
Sbjct: 679 VAGSTELRY-GLRVNVPPRITLP----PSLPGPVLVNTPVRLTCNA----TGAPSPTLMW 729
Query: 282 MK 283
+K
Sbjct: 730 LK 731
Score = 45.4 bits (106), Expect = 2e-04
Identities = 61/237 (25%), Positives = 82/237 (34%), Gaps = 36/237 (15%)
Query: 111 SGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKK 170
+G YTC RNS + LTV + S +R + + EV E S
Sbjct: 2640 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS--------- 2690
Query: 171 SDQEPDVVWYKE-CKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTEL 229
P + W KE S + G L I ED GNY C K + +
Sbjct: 2691 GIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSA-----GSAM 2745
Query: 230 KVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIE 289
T L+ PP +EN + G +PCKA G P I W K + +
Sbjct: 2746 GKTRLVVQVPP----VIENGLPDLSTTEGSHAFLPCKA----RGSPEPNITWDKDGQPVS 2797
Query: 290 ELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
G + + GE L+ ++ D YTC EN GR V L
Sbjct: 2798 GAEG-------KFTIQPSGE------LLVKNLEGQDAGTYTCTAENAVGRARRRVHL 2841
Score = 44.3 bits (103), Expect = 4e-04
Identities = 55/224 (24%), Positives = 90/224 (40%), Gaps = 33/224 (14%)
Query: 76 WYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNST------YCMKVSM 129
W K+ L + + +R + S+ A D+G YTCV N + + V +
Sbjct: 1969 WLKDGSPLGQDM-GPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLV 2027
Query: 130 SLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPK--M 187
T+ + G S E+ + CP + V W K+ P
Sbjct: 2028 PPTIKQGADG----SGTLVSRPGELVT---MVCP-----VRGSPPIHVSWLKDGLPLPLS 2075
Query: 188 WRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPME 247
R+++ G+ L I +VQ D G +TC + R L+V + P L P+E
Sbjct: 2076 QRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLEPVE 2129
Query: 248 NQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK-GEKFIEE 290
Q V+ V+ G + +PC+A G P++ WMK GE + +
Sbjct: 2130 FQNDVVVVR-GSLVELPCEA----RGVPLPLVSWMKDGEPLLSQ 2168
Score = 43.9 bits (102), Expect = 5e-04
Identities = 46/192 (23%), Positives = 80/192 (41%), Gaps = 23/192 (11%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDM 165
A++ D+G YTC N+ + + L V + R Y+ K+ + + C
Sbjct: 281 AQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGR-PYVVKAVAGRPVALEC--- 336
Query: 166 DDFKKSDQEPDVVWYKECKP--KMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEG--K 221
+ P + W+ E P + S + G+ L ++ E G Y+C
Sbjct: 337 --VARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEA 394
Query: 222 LVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
+++ + E++V P L E V + +G+PL +PC+A SG P I W
Sbjct: 395 VLQYSVEVQV--------PPQLLVAEGLGQVTTI-VGQPLELPCQA----SGSPVPTIQW 441
Query: 282 MKGEKFIEELAG 293
++ + EELAG
Sbjct: 442 LQNGRPAEELAG 453
Score = 41.2 bits (95), Expect = 0.003
Identities = 33/131 (25%), Positives = 58/131 (44%), Gaps = 13/131 (9%)
Query: 175 PDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTAL 234
P V W K+ +P + +S+ ++G +L ++ V D G Y+C E RR +L V
Sbjct: 2154 PLVSWMKDGEPLLSQSL--EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM-- 2209
Query: 235 LTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGH 294
+PP QP+ + + G P+ + C A G P I W K + + L +
Sbjct: 2210 ---EPPH--IEDSGQPTELSLTPGAPMELLCDA----QGTPQPNITWHKDGQALTRLENN 2260
Query: 295 IREGEIRLLKE 305
R + +++
Sbjct: 2261 SRATRVLRVRD 2271
Score = 40.0 bits (92), Expect = 0.007
Identities = 44/183 (24%), Positives = 72/183 (39%), Gaps = 28/183 (15%)
Query: 165 MDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGN-ALLIQEVQEEDGGNYTCELKYEGKLV 223
+D + D PD+ W K+ P + Q N +L I+ + +D G Y C + E +
Sbjct: 2956 LDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVA 3015
Query: 224 RRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
++ L + + P+F +E P + V+ G + + C+A +GE P I W++
Sbjct: 3016 KKVVILVLQS-------APVFQVE--PQDMTVRSGDDVALRCQA----TGEPTPTIEWLQ 3062
Query: 284 GEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHAS 343
AG RL G +L ++V D Y C N G A
Sbjct: 3063 --------AGQPLRASRRLRTLPDG------SLWLENVETGDAGTYDCVAHNLLGSATAR 3108
Query: 344 VLL 346
L
Sbjct: 3109 AFL 3111
Score = 38.9 bits (89), Expect = 0.016
Identities = 72/307 (23%), Positives = 115/307 (37%), Gaps = 50/307 (16%)
Query: 44 LAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNKGDLEEPIIFSEVRMSKEEDSIWF 103
L PVR+ C N + A S LMW K+ G+ P +++ +
Sbjct: 708 LVNTPVRLTC---------NATGAPSP--TLMWLKD-GNPVSPAGTPGLQVFPGGRVLTL 755
Query: 104 HSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCP 163
SA A DSG Y+CV ++ + + L V S L + + V + C
Sbjct: 756 ASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVA----LECQ 811
Query: 164 DMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEE--DGGNYTCELKYEGK 221
+ P + W+K+ +P R + + L+Q + + D G+YTCE +
Sbjct: 812 -----SHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAG 866
Query: 222 LVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
+ L V P+FP+ + + V+ G P + C+ G P I W
Sbjct: 867 HSEKHYNLNVWV-------APVFPL-RESHTLTVREGHPTRLSCEC----RGVPFPKISW 914
Query: 282 MK-GEKFIEELAGHIREGEI-RLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGR 339
K G+ E AG + RLL +LG+ ++ A YTC N G
Sbjct: 915 RKDGQPLPGEGAGLQHVSAVGRLL--YLGQAQL-----------AQEGTYTCECSNVVGN 961
Query: 340 KHASVLL 346
+ L
Sbjct: 962 SSQDLQL 968
Score = 38.1 bits (87), Expect = 0.027
Identities = 25/109 (22%), Positives = 42/109 (38%), Gaps = 12/109 (11%)
Query: 175 PDVVWYKE--CKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVT 232
P++ W+K+ P + + + G L + Q D G YTC+ + T L V
Sbjct: 250 PNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY 309
Query: 233 ALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYW 281
P + +P V+ G+P+ + C A G P + W
Sbjct: 310 V------PPTIEGAGGRPYVVKAVAGRPVALECVA----RGHPSPTLSW 348
Score = 38.1 bits (87), Expect = 0.027
Identities = 45/177 (25%), Positives = 66/177 (37%), Gaps = 28/177 (15%)
Query: 175 PDVVWYKECKPKMWRS--IIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVT 232
PD+ WY+E +P ++Q G L I V+ E+ G Y+C+ E EL V
Sbjct: 1498 PDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVL 1557
Query: 233 ALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK-GEKFIEEL 291
PP L E + V +++ C A G P I W++ G F
Sbjct: 1558 T-----PPVILGDTEELVEEVTVNASSTVSLQCPAL----GNPVPTISWLQNGLPFSPSP 1608
Query: 292 AGHIRE-GEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLR 347
+ E G++ L + AD A+Y C EN+ G LR
Sbjct: 1609 RLQVLEDGQV---------------LQVSTAEVADAASYMCVAENQAGSAEKLFTLR 1650
Score = 36.2 bits (82), Expect = 0.10
Identities = 29/119 (24%), Positives = 55/119 (46%), Gaps = 18/119 (15%)
Query: 105 SAEAQDSGFYTCVLRN------STYCMKVSMSLTVAENESGLCYNSRIRYLE-KSEVTKR 157
+A+ +D+G YTCV+ N Y ++V + ++++++ + + E K++V
Sbjct: 1319 NAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDP----LAEVGVKEVKTKVNST 1374
Query: 158 KEISCPDMDDFKKSDQEPDVVWYKECKP--KMWRSIIIQKGNALLIQEVQEEDGGNYTC 214
+ C + P + WYK+ +P R ++ +G L IQ Q D G Y C
Sbjct: 1375 LTLECESW-----AVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLC 1428
Score = 32.7 bits (73), Expect = 1.1
Identities = 53/254 (20%), Positives = 94/254 (37%), Gaps = 38/254 (14%)
Query: 92 VRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVA---ENESGLCYNSRIRY 148
+++ + S+ A+A +G Y+CV N + L+V E L + I
Sbjct: 1023 LQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITA 1082
Query: 149 LEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKM--WRSIIIQKGNALLIQEVQE 206
S +T + C M P + W++ +P + ++ G L + + QE
Sbjct: 1083 ALHSPLT----LLCEAM-----GIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQE 1133
Query: 207 EDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCK 266
+D G Y+C E RR ++V P E+ VI V G+ ++ C
Sbjct: 1134 QDSGLYSCLASNEAGEARRNFSVEVLV-------PPSIENEDLEEVIKVLDGQTAHLMCN 1186
Query: 267 AFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADL 326
+G P + W K + + H H+ V L ++ ++ A
Sbjct: 1187 V----TGHPQPKLTWFKDGRPLARGDAH-----------HISPDGVLLQVLQANLSSA-- 1229
Query: 327 ANYTCHVENRNGRK 340
+Y+C N G K
Sbjct: 1230 GHYSCIAANAVGEK 1243
Score = 32.3 bits (72), Expect = 1.5
Identities = 55/247 (22%), Positives = 91/247 (36%), Gaps = 36/247 (14%)
Query: 107 EAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMD 166
+ QDSG Y+C+ N + + S+ V S I + EV K + +
Sbjct: 1132 QEQDSGLYSCLASNEAGEARRNFSVEVLVPPS-------IENEDLEEVIKVLDGQTAHLM 1184
Query: 167 DFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQE--EDGGNYTCELKYEGKLVR 224
+P + W+K+ +P + +L+Q +Q G+Y+C +
Sbjct: 1185 CNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIA--ANAVGE 1242
Query: 225 RTTELKVTALLTDKPPKPLFPMENQ-PSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMK 283
+T +++ LL P L E+ + V + P+++ C+A P I WMK
Sbjct: 1243 KTKHFQLSVLLA---PTILGGAEDSADEEVTVTVNNPISLICEAL----AFPSPNITWMK 1295
Query: 284 GEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRK--- 340
E I+LL G L + + D YTC V N G
Sbjct: 1296 DGAPFE------ASRNIQLLPGTHG-------LQILNAQKEDAGQYTCVVTNELGEAVKN 1342
Query: 341 -HASVLL 346
H VL+
Sbjct: 1343 YHVEVLI 1349
Score = 32.0 bits (71), Expect = 2.0
Identities = 34/157 (21%), Positives = 61/157 (38%), Gaps = 32/157 (20%)
Query: 175 PDVVWYKECK----PKMWRSI-------------IIQKGNALLIQEVQEEDGGNYTCELK 217
P++VW K+ + P W ++ +G +L +QE D G Y+C +
Sbjct: 48 PEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAE 107
Query: 218 YEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGP 277
+ +R L V PP L Q V+ + G + + C SG P
Sbjct: 108 NQAGTAQRDFHLLVLT-----PPSVLGAGAAQ-EVLGL-AGADVELQCWT----SGVPTP 156
Query: 278 MIYWMKGEKFIEELAGHIREGE----IRLLKEHLGEK 310
+ W K + + H++ E +R+ H+G++
Sbjct: 157 QVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDE 193
Score = 31.6 bits (70), Expect = 2.6
Identities = 31/178 (17%), Positives = 66/178 (37%), Gaps = 42/178 (23%)
Query: 170 KSDQEPDVVWYKECKPKMWRSIIIQ---------KGNALLIQEVQEEDGGNYTCELKYEG 220
+++ P + W+++ I++Q +G L +Q + D G+Y+C +
Sbjct: 2324 EAEPAPKITWHRD-------GIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAA 2376
Query: 221 KLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIY 280
+++ + T + + P ++V + + +PC+A G P++
Sbjct: 2377 GSTSVAFRVEIHTVPT---------IRSGPPAVNVSVNQTALLPCQA----DGVPAPLVS 2423
Query: 281 WMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNG 338
W K ++ R +L E +L V+ D +Y C N G
Sbjct: 2424 WRKDRVPLDP-----RSPRFEILPEG--------SLRIQPVLAQDAGHYLCLASNSAG 2468
Score = 31.6 bits (70), Expect = 2.6
Identities = 55/256 (21%), Positives = 87/256 (33%), Gaps = 45/256 (17%)
Query: 98 EDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKR 157
E S+ AQD+G Y C+ NS + L V E + S + +
Sbjct: 2443 EGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLP 2502
Query: 158 KEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKG-------NALLIQEVQEEDGG 210
E S +P VVW+K+ + +R +Q+G NALL+ +D
Sbjct: 2503 CEAS---------GSPKPLVVWWKDGQKLDFR---LQQGAYRLLPSNALLLTAPGPQDSA 2550
Query: 211 NYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFG 270
+ C + E R ++ V PP + + + V + P+ + C +
Sbjct: 2551 QFECVVSNEVGEAHRLYQVTVHV-----PP----TIADDQTDFTVTMMAPVVLTCHS--- 2598
Query: 271 FSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYT 330
+G P + W K + R G E+ AL + YT
Sbjct: 2599 -TGIPAPTVSWSKAGAQLGARGSGYRVSP-------SGALEIGQALPIHA------GRYT 2644
Query: 331 CHVENRNGRKHASVLL 346
C N G H V L
Sbjct: 2645 CSARNSAGVAHKHVFL 2660
Score = 30.8 bits (68), Expect = 4.4
Identities = 52/258 (20%), Positives = 99/258 (38%), Gaps = 47/258 (18%)
Query: 85 EPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAE----NESGL 140
EP++ + ++ S+ + A DSG Y+CV + + LTV E +SG
Sbjct: 2163 EPLLSQSL---EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSG- 2218
Query: 141 CYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALL 200
+ +E++ + D + + Q P++ W+K+ +++ + N+
Sbjct: 2219 ---------QPTELSLTPGAPMELLCDAQGTPQ-PNITWHKD-----GQALTRLENNSRA 2263
Query: 201 IQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKP 260
+ ++ D G YTC + + ++ ++V A PP + P V+ + G+
Sbjct: 2264 TRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQA-----PPNIVGP-RGPRFVVGLAPGQ- 2316
Query: 261 LNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDS 320
L + C E P I W R+G + H E L +
Sbjct: 2317 LVLECSV----EAEPAPKITWH-------------RDGIVLQEDAHTQFPERGRFLQLQA 2359
Query: 321 VVEADLANYTCHVENRNG 338
+ AD +Y+C N G
Sbjct: 2360 LSTADSGDYSCTARNAAG 2377
Score = 30.4 bits (67), Expect = 5.7
Identities = 29/137 (21%), Positives = 53/137 (38%), Gaps = 24/137 (17%)
Query: 86 PIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSR 145
P+ S +R + S+ E D+G Y C +AENE G+
Sbjct: 2976 PLRGSHLRHQLQNGSLTIRRTERDDAGRYQC----------------LAENEMGVAKKVV 3019
Query: 146 IRYLEKSEV--TKRKEISCPDMDDF-----KKSDQEPDVVWYKECKP-KMWRSIIIQKGN 197
I L+ + V + ++++ DD + P + W + +P + R +
Sbjct: 3020 ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDG 3079
Query: 198 ALLIQEVQEEDGGNYTC 214
+L ++ V+ D G Y C
Sbjct: 3080 SLWLENVETGDAGTYDC 3096
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 51.2 bits (121), Expect = 3e-06
Identities = 43/164 (26%), Positives = 79/164 (48%), Gaps = 15/164 (9%)
Query: 399 NKEYDAYLSYTKVDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERDLIPSGTYME 458
N ++ A++SY+ D+ N E+LP+ LEK G ++ + ER+ +P + +E
Sbjct: 634 NLQFHAFISYS--GHDSFWVKN--------ELLPN-LEKE-GMQICLHERNFVPGKSIVE 681
Query: 459 DLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKGKVNC 518
++ +E+S + I VL+P+++ + W +EL HN+ G +ILI +
Sbjct: 682 NIITCIEKSYKSIFVLSPNFV-QSEWCHYELYFAHHNLFHEGSNSLILILLEPIPQYSIP 740
Query: 519 QEVESLKRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKE 562
LK + + ++W KS + FW +L + IK E
Sbjct: 741 SSYHKLKSLMARRTYLEWPKEKSKR--GLFWANLRAAINIKLTE 782
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 50.8 bits (120), Expect = 4e-06
Identities = 58/238 (24%), Positives = 89/238 (37%), Gaps = 39/238 (16%)
Query: 110 DSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFK 169
D G Y CV N+ + S+ L V E + S + + EV ++SC
Sbjct: 464 DGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEV----KVSCS-----A 514
Query: 170 KSDQEPDVVWYKECKPKMWRSII-IQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTE 228
P + W +E + S I + L+IQ V ED GNY+C+ E T +
Sbjct: 515 SGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNE----VGTDQ 570
Query: 229 LKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFI 288
VT TD P + +V+ V +G+ + C+A SG P + W +G +
Sbjct: 571 ETVTLYYTDPP-----SVSAVNAVVLVAVGEEAVLVCEA----SGVPPPRVIWYRGGLEM 621
Query: 289 EELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
G++R+ + E D YTC N G A + L
Sbjct: 622 ILAPEGSSSGKLRI----------------PAAQERDAGTYTCRAVNELGDASAEIQL 663
Score = 43.5 bits (101), Expect = 6e-04
Identities = 58/241 (24%), Positives = 94/241 (39%), Gaps = 36/241 (14%)
Query: 109 QDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDF 168
+D+G Y+C N + +++L + S N+ + E E S
Sbjct: 553 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEAS------- 605
Query: 169 KKSDQEPDVVWYKECKPKMWRSIIIQKGNA---LLIQEVQEEDGGNYTCELKYEGKLVRR 225
P V+WY+ I+ +G++ L I QE D G YTC E L
Sbjct: 606 --GVPPPRVIWYRGGL----EMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNE--LGDA 657
Query: 226 TTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGE 285
+ E++ L P+ + P + V+LG+ + C+A +G P + W +G+
Sbjct: 658 SAEIQ---LAVGHAPQ----LTELPRDVTVELGRSALLACRA----TGRPPPTVTWRRGD 706
Query: 286 KFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVL 345
+ L +R G R + + V L F+SV D A Y C N G+ A
Sbjct: 707 G--QPLG--LRLGAGRGSRSRQPDSGV---LFFESVAPEDQAPYVCEARNVFGKVQAEAR 759
Query: 346 L 346
L
Sbjct: 760 L 760
Score = 38.1 bits (87), Expect = 0.027
Identities = 39/165 (23%), Positives = 66/165 (40%), Gaps = 33/165 (20%)
Query: 193 IQKGNALLIQEVQEEDGGNYTCEL---------KYEGKLVRR--TTELKVTALLTDKPPK 241
+++G A L +E ++ GN + E+ YE V R T K ++TD PP+
Sbjct: 343 LRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQ 402
Query: 242 PLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIR 301
L P N + V G+ + C+ GE+ + W++ + + G + +
Sbjct: 403 -LVPAPN----VTVSPGETAVLSCRVL----GEAPYNLTWVRDWRVLPASTGRVAQ---- 449
Query: 302 LLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
+L+L ++ D Y C N NG ASV L
Sbjct: 450 ---------LADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 485
Score = 35.8 bits (81), Expect = 0.14
Identities = 32/145 (22%), Positives = 53/145 (36%), Gaps = 21/145 (14%)
Query: 175 PDVVWYKECKPKMWRS--IIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVT 232
P + W KE R + K LLI + +D G Y C + L V
Sbjct: 888 PTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVN 947
Query: 233 ALLTDKPPKPLFPME-----NQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKF 287
KP M N P + + G+ + + C+A G P++ W K +
Sbjct: 948 T-------KPRIHMNGSRNANVPLQVTAKAGEEVTLDCEA----KGSPPPLVTWTKDSRP 996
Query: 288 IEELA---GHIREGEIRLLKEHLGE 309
+ + G + G +RL + +G+
Sbjct: 997 VPPITNRYGLLPSGSLRLAQVQVGD 1021
Score = 33.5 bits (75), Expect = 0.67
Identities = 29/120 (24%), Positives = 45/120 (37%), Gaps = 4/120 (3%)
Query: 97 EEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTK 156
+E ++ AQD+G Y C N+ M L+V SR + K
Sbjct: 910 KEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAK 969
Query: 157 RKEISCPDMDDFKKSDQEPDVVWYKECK--PKMWRSIIIQKGNALLIQEVQEEDGGNYTC 214
E D + K P V W K+ + P + + +L + +VQ D G+Y C
Sbjct: 970 AGEEVTLDCE--AKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYEC 1027
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 50.8 bits (120), Expect = 4e-06
Identities = 58/238 (24%), Positives = 89/238 (37%), Gaps = 39/238 (16%)
Query: 110 DSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFK 169
D G Y CV N+ + S+ L V E + S + + EV ++SC
Sbjct: 580 DGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEV----KVSCS-----A 630
Query: 170 KSDQEPDVVWYKECKPKMWRSII-IQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTE 228
P + W +E + S I + L+IQ V ED GNY+C+ E T +
Sbjct: 631 SGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNE----VGTDQ 686
Query: 229 LKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFI 288
VT TD P + +V+ V +G+ + C+A SG P + W +G +
Sbjct: 687 ETVTLYYTDPP-----SVSAVNAVVLVAVGEEAVLVCEA----SGVPPPRVIWYRGGLEM 737
Query: 289 EELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
G++R+ + E D YTC N G A + L
Sbjct: 738 ILAPEGSSSGKLRI----------------PAAQERDAGTYTCRAVNELGDASAEIQL 779
Score = 38.1 bits (87), Expect = 0.027
Identities = 39/165 (23%), Positives = 66/165 (40%), Gaps = 33/165 (20%)
Query: 193 IQKGNALLIQEVQEEDGGNYTCEL---------KYEGKLVRR--TTELKVTALLTDKPPK 241
+++G A L +E ++ GN + E+ YE V R T K ++TD PP+
Sbjct: 459 LRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQ 518
Query: 242 PLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIR 301
L P N + V G+ + C+ GE+ + W++ + + G + +
Sbjct: 519 -LVPAPN----VTVSPGETAVLSCRVL----GEAPYNLTWVRDWRVLPASTGRVAQ---- 565
Query: 302 LLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL 346
+L+L ++ D Y C N NG ASV L
Sbjct: 566 ---------LADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 601
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 50.4 bits (119), Expect = 5e-06
Identities = 59/260 (22%), Positives = 104/260 (40%), Gaps = 39/260 (15%)
Query: 90 SEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYL 149
S++++ K + + + +D+G Y C+ NS VA L Y ++ ++
Sbjct: 271 SKIKLRKFSGVLEIPNFQQEDAGSYECIAENSR-------GKNVARGR--LTYYAKPHWV 321
Query: 150 EKSEVTKRKEISCPDMDDFK---KSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQE 206
+ + K EI+ D ++ +P W K + + AL I +
Sbjct: 322 Q---LIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERTQIENGALTISNLSV 378
Query: 207 EDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSVIDVQLGKPLNIPCK 266
D G + C + + LV + ELKV A D P+ ++ VQ+G +++ CK
Sbjct: 379 TDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPM------KKLVQVQVGSLVSLDCK 432
Query: 267 AFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADL 326
+ W KG+ ++E H R I LL + L +V +AD
Sbjct: 433 P----RASPRALSSWKKGDVSVQE---HER---ISLLNDG--------GLKIANVTKADA 474
Query: 327 ANYTCHVENRNGRKHASVLL 346
YTC EN+ G+ + + L
Sbjct: 475 GTYTCMAENQFGKANGTTHL 494
Score = 38.1 bits (87), Expect = 0.027
Identities = 45/194 (23%), Positives = 73/194 (37%), Gaps = 25/194 (12%)
Query: 76 WYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLTVAE 135
W KN L E R E ++ + DSG + C+ N + S L V
Sbjct: 351 WLKNGAAL-----VLEERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVA 405
Query: 136 NESGLCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQEPDVV--WYK-ECKPKMWRSII 192
+ N ++ L + +V + C K P + W K + + I
Sbjct: 406 SAPDFSKNP-MKKLVQVQVGSLVSLDC-------KPRASPRALSSWKKGDVSVQEHERIS 457
Query: 193 IQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSV 252
+ L I V + D G YTC + + TT L VT +P + + PS
Sbjct: 458 LLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVT-----EPTR----ITLAPSN 508
Query: 253 IDVQLGKPLNIPCK 266
+DV +G+ + +PC+
Sbjct: 509 MDVSVGESVILPCQ 522
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 50.1 bits (118), Expect = 7e-06
Identities = 77/382 (20%), Positives = 146/382 (38%), Gaps = 73/382 (19%)
Query: 39 KTYMALAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNK---GDLEEPIIFSEVRMS 95
+ Y+A GE + V+C L + + + W K+ G ++ E
Sbjct: 48 EVYVAAPGESLEVRCLLKDAAV-------------ISWTKDGVHLGPNNRTVLIGEYLQI 94
Query: 96 KEEDSIWFHSAEAQDSGFYTCVLRNST------YCMKVSMSLTVAENE----------SG 139
K A +DSG Y C + + + V+ +++ ++E S
Sbjct: 95 K--------GATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE 146
Query: 140 LCYNSRIRYLEKSEVTKRKEISCPDMDDFK-----KSDQEPDVVWYKECKP-----KMWR 189
N R Y +E +++ + P + K + P + W K K ++
Sbjct: 147 NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGG 206
Query: 190 SIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQ 249
+ + +L+++ V D GNYTC ++ E + T L V + P +P+
Sbjct: 207 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV---VERSPHRPIL-QAGL 262
Query: 250 PSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEH-LG 308
P+ +G + CK + ++ P I W+K + G +++LK +
Sbjct: 263 PANASTVVGGDVEFVCKVY----SDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGIN 318
Query: 309 EKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL----------RKKDLIYK---I 355
E+ +F +V EAD Y C V N G+ + S L R+K++ +
Sbjct: 319 SSNAEVLALF-NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYL 377
Query: 356 ELAGGLGAIFLLLVLLVVIYKC 377
E+A +FL+ ++V + C
Sbjct: 378 EIAIYCIGVFLIACMVVTVILC 399
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 50.1 bits (118), Expect = 7e-06
Identities = 77/382 (20%), Positives = 146/382 (38%), Gaps = 73/382 (19%)
Query: 39 KTYMALAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYKNK---GDLEEPIIFSEVRMS 95
+ Y+A GE + V+C L + + + W K+ G ++ E
Sbjct: 48 EVYVAAPGESLEVRCLLKDAAV-------------ISWTKDGVHLGPNNRTVLIGEYLQI 94
Query: 96 KEEDSIWFHSAEAQDSGFYTCVLRNST------YCMKVSMSLTVAENE----------SG 139
K A +DSG Y C + + + V+ +++ ++E S
Sbjct: 95 K--------GATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE 146
Query: 140 LCYNSRIRYLEKSEVTKRKEISCPDMDDFK-----KSDQEPDVVWYKECKP-----KMWR 189
N R Y +E +++ + P + K + P + W K K ++
Sbjct: 147 NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGG 206
Query: 190 SIIIQKGNALLIQEVQEEDGGNYTCELKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQ 249
+ + +L+++ V D GNYTC ++ E + T L V + P +P+
Sbjct: 207 YKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDV---VERSPHRPIL-QAGL 262
Query: 250 PSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEH-LG 308
P+ +G + CK + ++ P I W+K + G +++LK +
Sbjct: 263 PANASTVVGGDVEFVCKVY----SDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGIN 318
Query: 309 EKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLL----------RKKDLIYK---I 355
E+ +F +V EAD Y C V N G+ + S L R+K++ +
Sbjct: 319 SSNAEVLALF-NVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDYL 377
Query: 356 ELAGGLGAIFLLLVLLVVIYKC 377
E+A +FL+ ++V + C
Sbjct: 378 EIAIYCIGVFLIACMVVTVILC 399
>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
Length = 1863
Score = 50.1 bits (118), Expect = 7e-06
Identities = 69/301 (22%), Positives = 116/301 (38%), Gaps = 62/301 (20%)
Query: 73 RLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLT 132
R+ W N +PI ++ + A +D G YTC+ N+ + S +T
Sbjct: 544 RITWLLNG----QPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVT 599
Query: 133 VAENESG-------------------LCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQ 173
V E +S L S ++ ++ S+VT ++S +
Sbjct: 600 VHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVS---------GNP 650
Query: 174 EPDVVWYKECKPKMWRSIII--QKG--NALLIQEVQEEDGGNYTCELKYEGKLVRRTTEL 229
P+V+W Q+G ++L IQEV ED G YTCE E+
Sbjct: 651 PPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCE------AWNSAGEV 704
Query: 230 KVTALLTDKPP----KPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGE 285
+ A+LT + P +P F ++P + LG+ + I C +G+ P ++W++
Sbjct: 705 RTQAVLTVQEPHDGTQPWF--ISKPRSVTASLGQSVLISC----AIAGDPFPTVHWLRDG 758
Query: 286 KFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVL 345
K + + GH E L ++V L+ V Y ++NR G V
Sbjct: 759 KALCKDTGHF---------EVLQNEDV-FTLVLKKVQPWHAGQYEILLKNRVGECSCQVS 808
Query: 346 L 346
L
Sbjct: 809 L 809
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/205 (24%), Positives = 79/205 (38%), Gaps = 49/205 (23%)
Query: 174 EPDVVWYKECKP-----KMWRSIIIQKGNALLIQEVQEEDGGNYTC-------------E 215
EP V W++ +P + I+ +L+I V EED G YTC E
Sbjct: 61 EPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE 120
Query: 216 LKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSV--------------IDVQLGKPL 261
L EG ++ + V+ L D+ P +E +PS+ + V+ G+
Sbjct: 121 LTVEGSFAKQLGQPVVSKTLGDRFSAP--AVETRPSIWGECPPKFATKLGRVVVKEGQMG 178
Query: 262 NIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSV 321
CK +G P + W+KG ++ A + + EK L V
Sbjct: 179 RFSCK----ITGRPQPQVTWLKGNVPLQPSA-----------RVSVSEKNGMQVLEIHGV 223
Query: 322 VEADLANYTCHVENRNGRKHASVLL 346
+ D+ YTC V N +G+ S L
Sbjct: 224 NQDDVGVYTCLVVNGSGKASMSAEL 248
Score = 40.8 bits (94), Expect = 0.004
Identities = 58/259 (22%), Positives = 91/259 (35%), Gaps = 43/259 (16%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLE--KSEVTKRKEISCP 163
A +DSG Y+C N+ + S +L V R+ +E S + K+ +
Sbjct: 477 ARTRDSGTYSCTASNAQGQLSCSWTLQV----------ERLAVMEVAPSFSSVLKDCAVI 526
Query: 164 DMDDF-----KKSDQEPDVVWYKECKPKMWRSIIIQKGNA-LLIQEVQEEDGGNYTCELK 217
+ DF + P + W +P + + G A L IQ+ ED G YTC +
Sbjct: 527 EGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAE 586
Query: 218 YEGKLV---------RRTTELKVTALLTDKPPKPLFPMENQP-SVIDVQLGKPLNIPCKA 267
V + + K LL P KP P+ Q S + V G + + +
Sbjct: 587 NALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQV 646
Query: 268 FFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLA 327
SG P + W+ I+E H ++ + +L V D
Sbjct: 647 ----SGNPPPEVIWLHNGNEIQESEDF-----------HFEQRGTQHSLCIQEVFPEDTG 691
Query: 328 NYTCHVENRNGRKHASVLL 346
YTC N G +L
Sbjct: 692 TYTCEAWNSAGEVRTQAVL 710
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 50.1 bits (118), Expect = 7e-06
Identities = 69/301 (22%), Positives = 116/301 (38%), Gaps = 62/301 (20%)
Query: 73 RLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLT 132
R+ W N +PI ++ + A +D G YTC+ N+ + S +T
Sbjct: 544 RITWLLNG----QPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVT 599
Query: 133 VAENESG-------------------LCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQ 173
V E +S L S ++ ++ S+VT ++S +
Sbjct: 600 VHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVS---------GNP 650
Query: 174 EPDVVWYKECKPKMWRSIII--QKG--NALLIQEVQEEDGGNYTCELKYEGKLVRRTTEL 229
P+V+W Q+G ++L IQEV ED G YTCE E+
Sbjct: 651 PPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCE------AWNSAGEV 704
Query: 230 KVTALLTDKPP----KPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGE 285
+ A+LT + P +P F ++P + LG+ + I C +G+ P ++W++
Sbjct: 705 RTQAVLTVQEPHDGTQPWF--ISKPRSVTASLGQSVLISC----AIAGDPFPTVHWLRDG 758
Query: 286 KFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVL 345
K + + GH E L ++V L+ V Y ++NR G V
Sbjct: 759 KALCKDTGHF---------EVLQNEDV-FTLVLKKVQPWHAGQYEILLKNRVGECSCQVS 808
Query: 346 L 346
L
Sbjct: 809 L 809
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/205 (24%), Positives = 79/205 (38%), Gaps = 49/205 (23%)
Query: 174 EPDVVWYKECKP-----KMWRSIIIQKGNALLIQEVQEEDGGNYTC-------------E 215
EP V W++ +P + I+ +L+I V EED G YTC E
Sbjct: 61 EPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE 120
Query: 216 LKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSV--------------IDVQLGKPL 261
L EG ++ + V+ L D+ P +E +PS+ + V+ G+
Sbjct: 121 LTVEGSFAKQLGQPVVSKTLGDRFSAP--AVETRPSIWGECPPKFATKLGRVVVKEGQMG 178
Query: 262 NIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSV 321
CK +G P + W+KG ++ A + + EK L V
Sbjct: 179 RFSCK----ITGRPQPQVTWLKGNVPLQPSA-----------RVSVSEKNGMQVLEIHGV 223
Query: 322 VEADLANYTCHVENRNGRKHASVLL 346
+ D+ YTC V N +G+ S L
Sbjct: 224 NQDDVGVYTCLVVNGSGKASMSAEL 248
Score = 40.8 bits (94), Expect = 0.004
Identities = 58/259 (22%), Positives = 91/259 (35%), Gaps = 43/259 (16%)
Query: 106 AEAQDSGFYTCVLRNSTYCMKVSMSLTVAENESGLCYNSRIRYLE--KSEVTKRKEISCP 163
A +DSG Y+C N+ + S +L V R+ +E S + K+ +
Sbjct: 477 ARTRDSGTYSCTASNAQGQLSCSWTLQV----------ERLAVMEVAPSFSSVLKDCAVI 526
Query: 164 DMDDF-----KKSDQEPDVVWYKECKPKMWRSIIIQKGNA-LLIQEVQEEDGGNYTCELK 217
+ DF + P + W +P + + G A L IQ+ ED G YTC +
Sbjct: 527 EGQDFVLQCSVRGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAE 586
Query: 218 YEGKLV---------RRTTELKVTALLTDKPPKPLFPMENQP-SVIDVQLGKPLNIPCKA 267
V + + K LL P KP P+ Q S + V G + + +
Sbjct: 587 NALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQV 646
Query: 268 FFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLA 327
SG P + W+ I+E H ++ + +L V D
Sbjct: 647 ----SGNPPPEVIWLHNGNEIQESEDF-----------HFEQRGTQHSLCIQEVFPEDTG 691
Query: 328 NYTCHVENRNGRKHASVLL 346
YTC N G +L
Sbjct: 692 TYTCEAWNSAGEVRTQAVL 710
>gi|116008190 myosin light chain kinase isoform 3B [Homo sapiens]
Length = 1794
Score = 50.1 bits (118), Expect = 7e-06
Identities = 69/301 (22%), Positives = 116/301 (38%), Gaps = 62/301 (20%)
Query: 73 RLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLT 132
R+ W N +PI ++ + A +D G YTC+ N+ + S +T
Sbjct: 475 RITWLLNG----QPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVT 530
Query: 133 VAENESG-------------------LCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQ 173
V E +S L S ++ ++ S+VT ++S +
Sbjct: 531 VHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVS---------GNP 581
Query: 174 EPDVVWYKECKPKMWRSIII--QKG--NALLIQEVQEEDGGNYTCELKYEGKLVRRTTEL 229
P+V+W Q+G ++L IQEV ED G YTCE E+
Sbjct: 582 PPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCE------AWNSAGEV 635
Query: 230 KVTALLTDKPP----KPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGE 285
+ A+LT + P +P F ++P + LG+ + I C +G+ P ++W++
Sbjct: 636 RTQAVLTVQEPHDGTQPWF--ISKPRSVTASLGQSVLISC----AIAGDPFPTVHWLRDG 689
Query: 286 KFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVL 345
K + + GH E L ++V L+ V Y ++NR G V
Sbjct: 690 KALCKDTGHF---------EVLQNEDV-FTLVLKKVQPWHAGQYEILLKNRVGECSCQVS 739
Query: 346 L 346
L
Sbjct: 740 L 740
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/205 (24%), Positives = 79/205 (38%), Gaps = 49/205 (23%)
Query: 174 EPDVVWYKECKP-----KMWRSIIIQKGNALLIQEVQEEDGGNYTC-------------E 215
EP V W++ +P + I+ +L+I V EED G YTC E
Sbjct: 61 EPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE 120
Query: 216 LKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSV--------------IDVQLGKPL 261
L EG ++ + V+ L D+ P +E +PS+ + V+ G+
Sbjct: 121 LTVEGSFAKQLGQPVVSKTLGDRFSAP--AVETRPSIWGECPPKFATKLGRVVVKEGQMG 178
Query: 262 NIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSV 321
CK +G P + W+KG ++ A + + EK L V
Sbjct: 179 RFSCK----ITGRPQPQVTWLKGNVPLQPSA-----------RVSVSEKNGMQVLEIHGV 223
Query: 322 VEADLANYTCHVENRNGRKHASVLL 346
+ D+ YTC V N +G+ S L
Sbjct: 224 NQDDVGVYTCLVVNGSGKASMSAEL 248
>gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens]
Length = 1845
Score = 50.1 bits (118), Expect = 7e-06
Identities = 69/301 (22%), Positives = 116/301 (38%), Gaps = 62/301 (20%)
Query: 73 RLMWYKNKGDLEEPIIFSEVRMSKEEDSIWFHSAEAQDSGFYTCVLRNSTYCMKVSMSLT 132
R+ W N +PI ++ + A +D G YTC+ N+ + S +T
Sbjct: 475 RITWLLNG----QPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVT 530
Query: 133 VAENESG-------------------LCYNSRIRYLEKSEVTKRKEISCPDMDDFKKSDQ 173
V E +S L S ++ ++ S+VT ++S +
Sbjct: 531 VHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVS---------GNP 581
Query: 174 EPDVVWYKECKPKMWRSIII--QKG--NALLIQEVQEEDGGNYTCELKYEGKLVRRTTEL 229
P+V+W Q+G ++L IQEV ED G YTCE E+
Sbjct: 582 PPEVIWLHNGNEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCE------AWNSAGEV 635
Query: 230 KVTALLTDKPP----KPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGE 285
+ A+LT + P +P F ++P + LG+ + I C +G+ P ++W++
Sbjct: 636 RTQAVLTVQEPHDGTQPWF--ISKPRSVTASLGQSVLISC----AIAGDPFPTVHWLRDG 689
Query: 286 KFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVL 345
K + + GH E L ++V L+ V Y ++NR G V
Sbjct: 690 KALCKDTGHF---------EVLQNEDV-FTLVLKKVQPWHAGQYEILLKNRVGECSCQVS 739
Query: 346 L 346
L
Sbjct: 740 L 740
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/205 (24%), Positives = 79/205 (38%), Gaps = 49/205 (23%)
Query: 174 EPDVVWYKECKP-----KMWRSIIIQKGNALLIQEVQEEDGGNYTC-------------E 215
EP V W++ +P + I+ +L+I V EED G YTC E
Sbjct: 61 EPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE 120
Query: 216 LKYEGKLVRRTTELKVTALLTDKPPKPLFPMENQPSV--------------IDVQLGKPL 261
L EG ++ + V+ L D+ P +E +PS+ + V+ G+
Sbjct: 121 LTVEGSFAKQLGQPVVSKTLGDRFSAP--AVETRPSIWGECPPKFATKLGRVVVKEGQMG 178
Query: 262 NIPCKAFFGFSGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSV 321
CK +G P + W+KG ++ A + + EK L V
Sbjct: 179 RFSCK----ITGRPQPQVTWLKGNVPLQPSA-----------RVSVSEKNGMQVLEIHGV 223
Query: 322 VEADLANYTCHVENRNGRKHASVLL 346
+ D+ YTC V N +G+ S L
Sbjct: 224 NQDDVGVYTCLVVNGSGKASMSAEL 248
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,482,252
Number of Sequences: 37866
Number of extensions: 1237963
Number of successful extensions: 4757
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 156
Number of HSP's that attempted gapping in prelim test: 3345
Number of HSP's gapped (non-prelim): 1186
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.