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Search of human proteins with 112181200
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo
sapiens]
(443 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 910 0.0
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 809 0.0
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 679 0.0
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 642 0.0
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 642 0.0
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 641 0.0
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 536 e-152
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens] 445 e-125
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 243 2e-64
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 231 8e-61
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 231 8e-61
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 231 8e-61
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 223 4e-58
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 219 3e-57
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 215 6e-56
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 213 2e-55
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 208 7e-54
gi|11415052 retinoid X receptor, beta [Homo sapiens] 202 4e-52
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 200 2e-51
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 200 2e-51
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 199 5e-51
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 196 5e-50
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 194 1e-49
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 194 1e-49
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 194 1e-49
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 194 1e-49
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof... 187 2e-47
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof... 187 2e-47
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof... 187 2e-47
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 186 5e-47
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 910 bits (2353), Expect = 0.0
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MYDCMETFAPGPRRLYGAAGPGAGLLRRATGGSCFAGLESFAWPQPASLQSVETQSTSSE 60
MYDCMETFAPGPRRLYGAAGPGAGLLRRATGGSCFAGLESFAWPQPASLQSVETQSTSSE
Sbjct: 1 MYDCMETFAPGPRRLYGAAGPGAGLLRRATGGSCFAGLESFAWPQPASLQSVETQSTSSE 60
Query: 61 EMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKN 120
EMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKN
Sbjct: 61 EMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKN 120
Query: 121 CIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELIT 180
CIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELIT
Sbjct: 121 CIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELIT 180
Query: 181 KVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGF 240
KVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGF
Sbjct: 181 KVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGF 240
Query: 241 TGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLV 300
TGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLV
Sbjct: 241 TGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLV 300
Query: 301 FAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPS 360
FAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPS
Sbjct: 301 FAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPS 360
Query: 361 QPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGP 420
QPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGP
Sbjct: 361 QPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGP 420
Query: 421 HPNASSEDEVPGGQGKGGLKSPA 443
HPNASSEDEVPGGQGKGGLKSPA
Sbjct: 421 HPNASSEDEVPGGQGKGGLKSPA 443
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 809 bits (2090), Expect = 0.0
Identities = 409/453 (90%), Positives = 413/453 (91%), Gaps = 18/453 (3%)
Query: 9 APGPRRLY--GAAGPGAGL--------LRRATGGS--------CFAGLESFAWPQPASLQ 50
A RL+ GA GPG+G A GS F GL P+ +
Sbjct: 2 ATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASL 61
Query: 51 SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKN 110
SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKN
Sbjct: 62 SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKN 121
Query: 111 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE 170
MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE
Sbjct: 122 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE 181
Query: 171 LSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKI 230
LSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKI
Sbjct: 182 LSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKI 241
Query: 231 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHN 290
VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 242 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHN 301
Query: 291 AGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEAL 350
AGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEAL
Sbjct: 302 AGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEAL 361
Query: 351 RLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM 410
RLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM
Sbjct: 362 RLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM 421
Query: 411 FEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA 443
FEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
Sbjct: 422 FEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA 454
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 679 bits (1753), Expect = 0.0
Identities = 326/414 (78%), Positives = 364/414 (87%), Gaps = 2/414 (0%)
Query: 1 MYDCMETFAPGPRRL--YGAAGPGAGLLRRATGGSCFAGLESFAWPQPASLQSVETQSTS 58
M+DCM+ + P ++ + A P + +L+ +CF+GL W + QS+ETQSTS
Sbjct: 1 MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTS 60
Query: 59 SEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRD 118
SEE+VPS PSP PPPRVYKPCFVC DKSSGYHYGVS+CEGCKGFFRRSIQKNM+YTCHRD
Sbjct: 61 SEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRD 120
Query: 119 KNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEEL 178
KNC+INKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKE ++ +SYE++ +L++L
Sbjct: 121 KNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDL 180
Query: 179 ITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLP 238
K+ KAHQETFPSLCQLGKYTTNSSADHRV+LDLGLWDKFSELATKCIIKIVEFAKRLP
Sbjct: 181 TEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLP 240
Query: 239 GFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 298
GFTGL+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD
Sbjct: 241 GFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD 300
Query: 299 LVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRR 358
LVF FA QLLPLEMDDTETGLLSAICLICGDR DLEEP KVDKLQEPLLEAL++Y R+RR
Sbjct: 301 LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRR 360
Query: 359 PSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFE 412
PS+P+MFP++LMKITDLR IS KGAER ITLKMEIPG MPPLI+EMLEN E E
Sbjct: 361 PSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGHE 414
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 642 bits (1657), Expect = 0.0
Identities = 314/405 (77%), Positives = 350/405 (86%), Gaps = 14/405 (3%)
Query: 38 LESFAWPQPASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCE 97
+ ++ P PA+ +ETQS+SSEE+VPS PSPPP PR+YKPCFVC DKSSGYHYGVS+CE
Sbjct: 50 VSGYSTPSPAT---IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACE 106
Query: 98 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKK 157
GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKK
Sbjct: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
Query: 158 KEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWD 217
KEV + +SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S++ RV LD+ LWD
Sbjct: 167 KEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWD 226
Query: 218 KFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTF 277
KFSEL+TKCIIK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRICTRYTPEQDTMTF
Sbjct: 227 KFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTF 286
Query: 278 SDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPE 337
SDGLTLNRTQMHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAICLICGDR DLE+P+
Sbjct: 287 SDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPD 346
Query: 338 KVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM 397
+VD LQEPLLEAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAER ITLKMEIPG M
Sbjct: 347 RVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSM 406
Query: 398 PPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 442
PPLI+EMLEN E + S QPG GG+ GGL P
Sbjct: 407 PPLIQEMLENSEGLDTLSGQPG-----------GGGRDGGGLAPP 440
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 642 bits (1657), Expect = 0.0
Identities = 314/405 (77%), Positives = 350/405 (86%), Gaps = 14/405 (3%)
Query: 38 LESFAWPQPASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCE 97
+ ++ P PA+ +ETQS+SSEE+VPS PSPPP PR+YKPCFVC DKSSGYHYGVS+CE
Sbjct: 50 VSGYSTPSPAT---IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACE 106
Query: 98 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKK 157
GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKK
Sbjct: 107 GCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKK 166
Query: 158 KEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWD 217
KEV + +SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S++ RV LD+ LWD
Sbjct: 167 KEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWD 226
Query: 218 KFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTF 277
KFSEL+TKCIIK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRICTRYTPEQDTMTF
Sbjct: 227 KFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTF 286
Query: 278 SDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPE 337
SDGLTLNRTQMHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAICLICGDR DLE+P+
Sbjct: 287 SDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPD 346
Query: 338 KVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM 397
+VD LQEPLLEAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAER ITLKMEIPG M
Sbjct: 347 RVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSM 406
Query: 398 PPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 442
PPLI+EMLEN E + S QPG GG+ GGL P
Sbjct: 407 PPLIQEMLENSEGLDTLSGQPG-----------GGGRDGGGLAPP 440
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 641 bits (1654), Expect = 0.0
Identities = 313/395 (79%), Positives = 345/395 (87%), Gaps = 11/395 (2%)
Query: 48 SLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSI 107
S S+ETQS+SSEE+VPS PSPPP PR+YKPCFVC DKSSGYHYGVS+CEGCKGFFRRSI
Sbjct: 52 SNHSIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSI 111
Query: 108 QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPD 167
QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKEV + +
Sbjct: 112 QKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSE 171
Query: 168 SYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCI 227
SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCI
Sbjct: 172 SYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCI 231
Query: 228 IKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQ 287
IK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNRTQ
Sbjct: 232 IKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQ 291
Query: 288 MHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLL 347
MHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAICLICGDR DLE+P++VD LQEPLL
Sbjct: 292 MHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLL 351
Query: 348 EALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLEN 407
EAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAER ITLKMEIPG MPPLI+EMLEN
Sbjct: 352 EALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLEN 411
Query: 408 PEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 442
E + S QPG GG+ GGL P
Sbjct: 412 SEGLDTLSGQPG-----------GGGRDGGGLAPP 435
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 536 bits (1381), Expect = e-152
Identities = 258/302 (85%), Positives = 281/302 (93%)
Query: 111 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE 170
M+YTCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKE ++ +SYE
Sbjct: 1 MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYE 60
Query: 171 LSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKI 230
++ +L++L K+ KAHQETFPSLCQLGKYTTNSSADHRV+LDLGLWDKFSELATKCIIKI
Sbjct: 61 MTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKI 120
Query: 231 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHN 290
VEFAKRLPGFTGL+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 121 VEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 180
Query: 291 AGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEAL 350
AGFGPLTDLVF FA QLLPLEMDDTETGLLSAICLICGDR DLEEP KVDKLQEPLLEAL
Sbjct: 181 AGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEAL 240
Query: 351 RLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM 410
++Y R+RRPS+P+MFP++LMKITDLR IS KGAER ITLKMEIPG MPPLI+EMLEN E
Sbjct: 241 KIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 300
Query: 411 FE 412
E
Sbjct: 301 HE 302
>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
Length = 365
Score = 445 bits (1144), Expect = e-125
Identities = 224/298 (75%), Positives = 250/298 (83%), Gaps = 11/298 (3%)
Query: 145 SKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSS 204
S VRNDRNKKKKEV + +SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S
Sbjct: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
Query: 205 ADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRI 264
++ RV LD+ LWDKFSEL+TKCIIK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRI
Sbjct: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
Query: 265 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAIC 324
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAIC
Sbjct: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
Query: 325 LICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAE 384
LICGDR DLE+P++VD LQEPLLEAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAE
Sbjct: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
Query: 385 RAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 442
R ITLKMEIPG MPPLI+EMLEN E + S QPG GG+ GGL P
Sbjct: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPG-----------GGGRDGGGLAPP 343
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 243 bits (621), Expect = 2e-64
Identities = 134/358 (37%), Positives = 202/358 (56%), Gaps = 26/358 (7%)
Query: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 136
C VC DK++GYHY +CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 137 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 183
+KC VGM+ + V +D R +++KE E +P+ +LI +
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 184 KAHQETFPSLC---QLGKYTTNSSADHRV-------QLDLGLWDKFSELATKCIIKIVEF 233
+AH+ T Q K+ + + ++DL + +F+++ T I ++V+F
Sbjct: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 234 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 293
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 294 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 353
G ++D +F L +DDTE LL A+ L+ DR L +K++K QE L A Y
Sbjct: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
Query: 354 ARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM-PPLIREMLENPEM 410
R+ + P+ +P++LMK+TDLR I A R + +K+E P + PPL E+ E+ E+
Sbjct: 353 VNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV 410
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 231 bits (590), Expect = 8e-61
Identities = 136/387 (35%), Positives = 209/387 (54%), Gaps = 32/387 (8%)
Query: 47 ASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRS 106
+S Q+ +T+ + +PS + C VC DK++GYHY +CEGCKGFFRR+
Sbjct: 81 SSAQTFQTEEKKCKGYIPSYLDKD------ELCVVCGDKATGYHYRCITCEGCKGFFRRT 134
Query: 107 IQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRND------------ 152
IQKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 135 IQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEE 194
Query: 153 -RNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLC---QLGKYTTNS----- 203
R K+++E ++ E + + ELI V++AH T Q K+
Sbjct: 195 NREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAP 254
Query: 204 --SADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILM 261
+A ++DL + F+++ T I ++V+FAK+LP F L DQI LLK C++I+
Sbjct: 255 IVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMS 314
Query: 262 LRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLS 321
LR RY PE +T+T + + + R Q+ N G G ++D +F L +DDTE LL
Sbjct: 315 LRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQ 374
Query: 322 AICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTK 381
A+ L+ DR L E+++K Q+ L A Y R+ + +P++LMK+TDLR I
Sbjct: 375 AVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGAC 434
Query: 382 GAERAITLKMEIPGPM-PPLIREMLEN 407
A R + +K+E P + PPL E+ E+
Sbjct: 435 HASRFLHMKVECPTELFPPLFLEVFED 461
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 231 bits (590), Expect = 8e-61
Identities = 136/387 (35%), Positives = 209/387 (54%), Gaps = 32/387 (8%)
Query: 47 ASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRS 106
+S Q+ +T+ + +PS + C VC DK++GYHY +CEGCKGFFRR+
Sbjct: 81 SSAQTFQTEEKKCKGYIPSYLDKD------ELCVVCGDKATGYHYRCITCEGCKGFFRRT 134
Query: 107 IQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRND------------ 152
IQKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 135 IQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEE 194
Query: 153 -RNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLC---QLGKYTTNS----- 203
R K+++E ++ E + + ELI V++AH T Q K+
Sbjct: 195 NREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAP 254
Query: 204 --SADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILM 261
+A ++DL + F+++ T I ++V+FAK+LP F L DQI LLK C++I+
Sbjct: 255 IVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMS 314
Query: 262 LRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLS 321
LR RY PE +T+T + + + R Q+ N G G ++D +F L +DDTE LL
Sbjct: 315 LRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQ 374
Query: 322 AICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTK 381
A+ L+ DR L E+++K Q+ L A Y R+ + +P++LMK+TDLR I
Sbjct: 375 AVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGAC 434
Query: 382 GAERAITLKMEIPGPM-PPLIREMLEN 407
A R + +K+E P + PPL E+ E+
Sbjct: 435 HASRFLHMKVECPTELFPPLFLEVFED 461
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 231 bits (590), Expect = 8e-61
Identities = 136/387 (35%), Positives = 209/387 (54%), Gaps = 32/387 (8%)
Query: 47 ASLQSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRS 106
+S Q+ +T+ + +PS + C VC DK++GYHY +CEGCKGFFRR+
Sbjct: 81 SSAQTFQTEEKKCKGYIPSYLDKD------ELCVVCGDKATGYHYRCITCEGCKGFFRRT 134
Query: 107 IQKNM--VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRND------------ 152
IQKN+ Y+C + C+I+KVTRN+CQ CR +KC VGM+ + V +D
Sbjct: 135 IQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEE 194
Query: 153 -RNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLC---QLGKYTTNS----- 203
R K+++E ++ E + + ELI V++AH T Q K+
Sbjct: 195 NREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAP 254
Query: 204 --SADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILM 261
+A ++DL + F+++ T I ++V+FAK+LP F L DQI LLK C++I+
Sbjct: 255 IVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMS 314
Query: 262 LRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLS 321
LR RY PE +T+T + + + R Q+ N G G ++D +F L +DDTE LL
Sbjct: 315 LRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQ 374
Query: 322 AICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTK 381
A+ L+ DR L E+++K Q+ L A Y R+ + +P++LMK+TDLR I
Sbjct: 375 AVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGAC 434
Query: 382 GAERAITLKMEIPGPM-PPLIREMLEN 407
A R + +K+E P + PPL E+ E+
Sbjct: 435 HASRFLHMKVECPTELFPPLFLEVFED 461
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 223 bits (567), Expect = 4e-58
Identities = 134/409 (32%), Positives = 210/409 (51%), Gaps = 33/409 (8%)
Query: 13 RRLYGAAGPGAGLLRRATGGSCFAGLESFAWPQPASLQSVETQSTSSEEMVP-------- 64
R + A GP +G L G + A P+S +V +SSE++ P
Sbjct: 71 RVITSAMGPPSGALAAPPGINLVA--------PPSSQLNVVNSVSSSEDIKPLPGLPGIG 122
Query: 65 --SSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCI 122
+ PS P V C +C D+SSG HYGV SCEGCKGFF+R+I+K+++YTC +K+C+
Sbjct: 123 NMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCL 182
Query: 123 INKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEG--SPDSYELSPQLEELIT 180
I+K RNRCQYCR QKC +GM +EAV+ +R + ++ + E + +E P +
Sbjct: 183 IDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMP-----VE 237
Query: 181 KVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGF 240
++ +A P G +S + V A K + +VE+AKR+P F
Sbjct: 238 RILEAELAVEPKTESYGDMNMENSTNDPV-------TNICHAADKQLFTLVEWAKRIPHF 290
Query: 241 TGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLV 300
+ L++ DQ+ LL+A ++L+ R QD + + GL ++R+ H+AG G + D V
Sbjct: 291 SDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRV 350
Query: 301 FA-FAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRP 359
++ ++MD +E G L AI L D L P +V+ L+E + L Y +++ P
Sbjct: 351 LTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYP 410
Query: 360 SQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENP 408
QP F ++L+++ LR I K E K+ P+ + EMLE P
Sbjct: 411 EQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETP 459
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 219 bits (559), Expect = 3e-57
Identities = 122/331 (36%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 136
C VC DK++GYHY +CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 137 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 183
+KC VGM+ + V +D R +++KE E +P+ +LI +
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 184 KAHQETFPSLC---QLGKYTTNSSADHRV-------QLDLGLWDKFSELATKCIIKIVEF 233
+AH+ T Q K+ + + ++DL + +F+++ T I ++V+F
Sbjct: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 234 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 293
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 294 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 353
G ++D +F L +DDTE LL A+ L+ DR L +K++K QE L A Y
Sbjct: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
Query: 354 ARRRRPSQPYMFPRMLMKITDLR-GISTKGA 383
R+ + P+ +P++LMK +++ I KGA
Sbjct: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 215 bits (548), Expect = 6e-56
Identities = 132/430 (30%), Positives = 223/430 (51%), Gaps = 35/430 (8%)
Query: 5 METFAPGPRRLYGAAGPGAGLLRR-------ATGGSCFAGLESFAWPQPASLQSVETQST 57
+E + PG + A G+ + R + GG+ GLE+ +P +L + +
Sbjct: 18 VELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA---AEPTALLTRAEPPS 74
Query: 58 SSEEMVPSSPSPPPPPRVY--KPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTC 115
E+ P P P++ + C VC DK+SG+HY V SCEGCKGFFRRS+ K Y C
Sbjct: 75 EPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYIC 134
Query: 116 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY------ 169
H +C ++ R +CQ CRL+KC + GM +E V ++ + K++K + ++
Sbjct: 135 HSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPP 194
Query: 170 ----------ELSPQ----LEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGL 215
+LSP+ +E+L+ + ++ +F ++ + + H +
Sbjct: 195 RASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREARQQR 253
Query: 216 WDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTM 275
+ F+ELA + +IV+FAK+LPGF LS DQI LLK + +++++L RY P +++
Sbjct: 254 FAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESI 313
Query: 276 TFSDGLTLNRTQMHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLE 334
TF + NR AG + +F F+ + L+++D E LL AI + DR +++
Sbjct: 314 TFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQ 373
Query: 335 EPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIP 394
+ +V++LQ +EAL Y P MFPRMLMK+ LR +S+ +E+ L+++
Sbjct: 374 DQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-D 432
Query: 395 GPMPPLIREM 404
+PPL+ E+
Sbjct: 433 KKLPPLLSEI 442
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 213 bits (543), Expect = 2e-55
Identities = 126/399 (31%), Positives = 212/399 (53%), Gaps = 28/399 (7%)
Query: 29 ATGGSCFAGLESFAWPQPASLQSVETQSTSSEEMVPSSPSPPPPPRVY--KPCFVCNDKS 86
+ GG+ GLE+ +P +L + + E+ P P P++ + C VC DK+
Sbjct: 4 SAGGTAGVGLEA---AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKA 60
Query: 87 SGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSK 146
SG+HY V SCEGCKGFFRRS+ K Y CH +C ++ R +CQ CRL+KC + GM +
Sbjct: 61 SGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMRE 120
Query: 147 EAVRNDRNKKKKEVKEEGSPDSY----------------ELSPQ----LEELITKVSKAH 186
E V ++ + K++K + ++ +LSP+ +E+L+ + +
Sbjct: 121 ECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCN 180
Query: 187 QETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIA 246
+ +F ++ + + H + + F+ELA + +IV+FAK+LPGF LS
Sbjct: 181 RRSFSDRLRVTPWPM-APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSRE 239
Query: 247 DQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFAG 305
DQI LLK + +++++L RY P +++TF + NR AG + +F F+
Sbjct: 240 DQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSR 299
Query: 306 QLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMF 365
+ L+++D E LL AI + DR ++++ +V++LQ +EAL Y P MF
Sbjct: 300 AMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMF 359
Query: 366 PRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 404
PRMLMK+ LR +S+ +E+ L+++ +PPL+ E+
Sbjct: 360 PRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEI 397
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 208 bits (530), Expect = 7e-54
Identities = 119/347 (34%), Positives = 181/347 (52%), Gaps = 8/347 (2%)
Query: 63 VPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCI 122
VP+ PS C +C D+SSG HYGV SCEGCKGFF+R+++K++ YTC +K+C+
Sbjct: 119 VPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCL 178
Query: 123 INKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKV 182
I+K RNRCQYCR QKC +GM +EAV+ +R + K + E S E I +
Sbjct: 179 IDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEA 238
Query: 183 SKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTG 242
A + + + SS + V + A K + +VE+AKR+P F+
Sbjct: 239 ELAVEPKTETYVEANMGLNPSSPNDPV-------TNICQAADKQLFTLVEWAKRIPHFSE 291
Query: 243 LSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA 302
L + DQ+ LL+A ++L+ R +D + + GL ++R H+AG G + D V
Sbjct: 292 LPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLT 351
Query: 303 -FAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQ 361
++ ++MD TE G L AI L D L P +V+ L+E + +L Y + + P Q
Sbjct: 352 ELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQ 411
Query: 362 PYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENP 408
P F ++L+++ LR I K E K+ P+ + EMLE P
Sbjct: 412 PGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP 458
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 202 bits (515), Expect = 4e-52
Identities = 118/345 (34%), Positives = 187/345 (54%), Gaps = 10/345 (2%)
Query: 67 PSPPPPPRVYKP-CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINK 125
P PP P K C +C D+SSG HYGV SCEGCKGFF+R+I+K++ Y+C +K+C ++K
Sbjct: 192 PPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDK 251
Query: 126 VTRNRCQYCRLQKCFEVGMSKEAVRNDRNK-KKKEVKEEGSPDSYELSPQLEELITKVSK 184
RNRCQYCR QKC GM +EAV+ +R + K K+ EG+ + E P ++ ++
Sbjct: 252 RQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP-VDRILEAELA 310
Query: 185 AHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLS 244
Q++ + G + S+ + ++ + A K + +VE+AKR+P F+ L
Sbjct: 311 VEQKSDQGVEGPGGTGGSGSSPNDPVTNI------CQAADKQLFTLVEWAKRIPHFSSLP 364
Query: 245 IADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA-F 303
+ DQ+ LL+A ++L+ R +D + + GL ++R H+AG G + D V
Sbjct: 365 LDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRVLTEL 424
Query: 304 AGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPY 363
++ + MD TE G L AI L D L P +V+ L+E + +L Y +++ P Q
Sbjct: 425 VSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYPEQQG 484
Query: 364 MFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENP 408
F ++L+++ LR I K E K+ P+ + EMLE P
Sbjct: 485 RFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP 529
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 200 bits (508), Expect = 2e-51
Identities = 123/326 (37%), Positives = 180/326 (55%), Gaps = 7/326 (2%)
Query: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 138
C VC D +S HYGV +CEGCKGFF+R++QKN Y C +K+C ++K RNRCQ+CR QK
Sbjct: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
Query: 139 CFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGK 198
C VGM KE VR D K ++ + SP L+T + +AH ++ PS +L
Sbjct: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASP--ANLLTSLVRAHLDSGPSTAKLDY 384
Query: 199 YTTNSSA-DHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACL 257
H + D G +F +L + + I ++A+++PGF LS ADQ LL++A L
Sbjct: 385 SKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFL 444
Query: 258 DILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTET 317
++ +LR+ R P + + F GL L+R Q GFG D + AF+ L L +D
Sbjct: 445 ELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR-GFGDWIDSILAFSRSLHSLLVDVPAF 503
Query: 318 GLLSAICLICGDRMDLEEPEKVDKLQEPLLEALR--LYARRRRPSQPYMFPRMLMKITDL 375
LSA+ LI DR L+EP +V++LQ + L+ + A P R+L K+ +L
Sbjct: 504 ACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPEL 562
Query: 376 RGISTKGAERAITLKMEIPGPMPPLI 401
R + T+G +R LK+E P PP+I
Sbjct: 563 RTLCTQGLQRIFYLKLEDLVPPPPII 588
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 200 bits (508), Expect = 2e-51
Identities = 123/326 (37%), Positives = 180/326 (55%), Gaps = 7/326 (2%)
Query: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 138
C VC D +S HYGV +CEGCKGFF+R++QKN Y C +K+C ++K RNRCQ+CR QK
Sbjct: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
Query: 139 CFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGK 198
C VGM KE VR D K ++ + SP L+T + +AH ++ PS +L
Sbjct: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASP--ANLLTSLVRAHLDSGPSTAKLDY 384
Query: 199 YTTNSSA-DHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACL 257
H + D G +F +L + + I ++A+++PGF LS ADQ LL++A L
Sbjct: 385 SKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFL 444
Query: 258 DILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTET 317
++ +LR+ R P + + F GL L+R Q GFG D + AF+ L L +D
Sbjct: 445 ELFILRLAYRSKPGEGKLIFCSGLVLHRLQCAR-GFGDWIDSILAFSRSLHSLLVDVPAF 503
Query: 318 GLLSAICLICGDRMDLEEPEKVDKLQEPLLEALR--LYARRRRPSQPYMFPRMLMKITDL 375
LSA+ LI DR L+EP +V++LQ + L+ + A P R+L K+ +L
Sbjct: 504 ACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPEL 562
Query: 376 RGISTKGAERAITLKMEIPGPMPPLI 401
R + T+G +R LK+E P PP+I
Sbjct: 563 RTLCTQGLQRIFYLKLEDLVPPPPII 588
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 199 bits (505), Expect = 5e-51
Identities = 130/420 (30%), Positives = 206/420 (49%), Gaps = 64/420 (15%)
Query: 44 PQPASLQSVETQSTSSEEMVPSSPS----------PPPPPRVYKPCFVCNDKSSGYHYGV 93
P P + E S S + V P P P ++ C VC DK+SG+HY V
Sbjct: 42 PDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNV 101
Query: 94 SSCEGCKGFFRRSIQKNMV--YTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRN 151
SCEGCKGFFRRS+ + Y C C ++ R +CQ CRL+KC E GM ++ V +
Sbjct: 102 LSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLS 161
Query: 152 DRNKKKKEVKEEGSPDSYELS-----PQ-------------------------------- 174
+ +KK+++++ +S S PQ
Sbjct: 162 EEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLT 221
Query: 175 ------LEELITKVSKAHQETFPSLCQLGKYTTNS---SADHRVQLDLGLWDKFSELATK 225
+++L+ + ++ +F ++ + + S D R Q + F+ELA
Sbjct: 222 AAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQR----FAHFTELAII 277
Query: 226 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 285
+ +IV+FAK++PGF L DQI LLKA+ ++I++L RY E + +TF T ++
Sbjct: 278 SVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSK 337
Query: 286 TQMHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQE 344
H AG + +F F+ + L +DD E LL AI + DR +++EP +V+ LQ+
Sbjct: 338 DDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQ 397
Query: 345 PLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 404
P +EAL Y R +RP FPRMLMK+ LR +S+ +E+ L+++ +PPL+ E+
Sbjct: 398 PYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEI 456
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 196 bits (497), Expect = 5e-50
Identities = 126/383 (32%), Positives = 210/383 (54%), Gaps = 24/383 (6%)
Query: 39 ESFAWP----QPASLQSVETQSTSSEEMVPSS-PSPPP--PPRVYKPCFVCNDKSSGYHY 91
++FA P +PAS+ Q + +++ + PSPP P C VC D ++ HY
Sbjct: 216 QTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHY 275
Query: 92 GVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRN 151
GV +CEGCKGFF+R++QKN Y C +KNC ++K RNRCQYCR QKC VGM KE VR
Sbjct: 276 GVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRT 335
Query: 152 D-------RNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSS 204
D R K + +E SP S +S LI+ + +AH ++ P++ L ++
Sbjct: 336 DSLKGRRGRLPSKPKSPQEPSPPSPPVS-----LISALVRAHVDSNPAMTSLDYSRFQAN 390
Query: 205 ADHRVQ-LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLR 263
D+++ D +F +L T + I +A+++PGF L ADQ L ++A L++ +LR
Sbjct: 391 PDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESAFLELFVLR 450
Query: 264 ICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAI 323
+ R P + + F +G+ L+R Q GFG D + F+ L + +D + ++A+
Sbjct: 451 LAYRSNPVEGKLIFCNGVVLHRLQCVR-GFGEWIDSIVEFSSNLQNMNIDISAFSCIAAL 509
Query: 324 CLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRP--SQPYMFPRMLMKITDLRGISTK 381
++ +R L+EP++V++LQ ++ L+ + ++P ++L K+ +LR + T+
Sbjct: 510 AMVT-ERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQ 568
Query: 382 GAERAITLKMEIPGPMPPLIREM 404
G +R LK+E P P +I ++
Sbjct: 569 GLQRIFYLKLEDLVPPPAIIDKL 591
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 194 bits (494), Expect = 1e-49
Identities = 126/361 (34%), Positives = 183/361 (50%), Gaps = 20/361 (5%)
Query: 52 VETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM 111
VE T E M+ S P + C VC D +SGYHYGV+SCE CK FF+R+IQ N+
Sbjct: 86 VEDPQTKCEYMLNSMPK--------RLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNI 137
Query: 112 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR-----NKKKKEVKEEGSP 166
Y+C C I K R CQ CR KC +VGM KE VR DR K K+ + E SP
Sbjct: 138 EYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSP 197
Query: 167 DSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRV-QLDLGLWDKFSELATK 225
L+PQL + K + + L + D V D+ +LA +
Sbjct: 198 ---YLNPQL---VQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADR 251
Query: 226 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 285
++ I+ +AK +PGF+ LS+ADQ++LL++A ++IL+L + R +D + ++D ++
Sbjct: 252 ELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE 311
Query: 286 TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 345
Q AG L + + + ++++ E L AI L D M +E+ E V KLQ+
Sbjct: 312 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDV 371
Query: 346 LLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREML 405
L EAL+ Y + P +MLM + LR STK + +K+E PM L EML
Sbjct: 372 LHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
Query: 406 E 406
E
Sbjct: 432 E 432
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 194 bits (494), Expect = 1e-49
Identities = 126/361 (34%), Positives = 183/361 (50%), Gaps = 20/361 (5%)
Query: 52 VETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM 111
VE T E M+ S P + C VC D +SGYHYGV+SCE CK FF+R+IQ N+
Sbjct: 86 VEDPQTKCEYMLNSMPK--------RLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNI 137
Query: 112 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR-----NKKKKEVKEEGSP 166
Y+C C I K R CQ CR KC +VGM KE VR DR K K+ + E SP
Sbjct: 138 EYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSP 197
Query: 167 DSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRV-QLDLGLWDKFSELATK 225
L+PQL + K + + L + D V D+ +LA +
Sbjct: 198 ---YLNPQL---VQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADR 251
Query: 226 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 285
++ I+ +AK +PGF+ LS+ADQ++LL++A ++IL+L + R +D + ++D ++
Sbjct: 252 ELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE 311
Query: 286 TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 345
Q AG L + + + ++++ E L AI L D M +E+ E V KLQ+
Sbjct: 312 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDV 371
Query: 346 LLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREML 405
L EAL+ Y + P +MLM + LR STK + +K+E PM L EML
Sbjct: 372 LHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
Query: 406 E 406
E
Sbjct: 432 E 432
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 194 bits (494), Expect = 1e-49
Identities = 126/361 (34%), Positives = 183/361 (50%), Gaps = 20/361 (5%)
Query: 52 VETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM 111
VE T E M+ S P + C VC D +SGYHYGV+SCE CK FF+R+IQ N+
Sbjct: 109 VEDPQTKCEYMLNSMPK--------RLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNI 160
Query: 112 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR-----NKKKKEVKEEGSP 166
Y+C C I K R CQ CR KC +VGM KE VR DR K K+ + E SP
Sbjct: 161 EYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSP 220
Query: 167 DSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRV-QLDLGLWDKFSELATK 225
L+PQL + K + + L + D V D+ +LA +
Sbjct: 221 ---YLNPQL---VQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADR 274
Query: 226 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 285
++ I+ +AK +PGF+ LS+ADQ++LL++A ++IL+L + R +D + ++D ++
Sbjct: 275 ELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE 334
Query: 286 TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 345
Q AG L + + + ++++ E L AI L D M +E+ E V KLQ+
Sbjct: 335 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDV 394
Query: 346 LLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREML 405
L EAL+ Y + P +MLM + LR STK + +K+E PM L EML
Sbjct: 395 LHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEML 454
Query: 406 E 406
E
Sbjct: 455 E 455
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 194 bits (494), Expect = 1e-49
Identities = 126/361 (34%), Positives = 183/361 (50%), Gaps = 20/361 (5%)
Query: 52 VETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM 111
VE T E M+ S P + C VC D +SGYHYGV+SCE CK FF+R+IQ N+
Sbjct: 86 VEDPQTKCEYMLNSMPK--------RLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNI 137
Query: 112 VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR-----NKKKKEVKEEGSP 166
Y+C C I K R CQ CR KC +VGM KE VR DR K K+ + E SP
Sbjct: 138 EYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSP 197
Query: 167 DSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRV-QLDLGLWDKFSELATK 225
L+PQL + K + + L + D V D+ +LA +
Sbjct: 198 ---YLNPQL---VQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADR 251
Query: 226 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 285
++ I+ +AK +PGF+ LS+ADQ++LL++A ++IL+L + R +D + ++D ++
Sbjct: 252 ELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDE 311
Query: 286 TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 345
Q AG L + + + ++++ E L AI L D M +E+ E V KLQ+
Sbjct: 312 DQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDV 371
Query: 346 LLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREML 405
L EAL+ Y + P +MLM + LR STK + +K+E PM L EML
Sbjct: 372 LHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
Query: 406 E 406
E
Sbjct: 432 E 432
>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
b [Homo sapiens]
Length = 637
Score = 187 bits (474), Expect = 2e-47
Identities = 130/402 (32%), Positives = 199/402 (49%), Gaps = 37/402 (9%)
Query: 29 ATGGSCFAGLESFAWPQPASLQSVE--------TQSTSSEEMVPSSPSPPPPPRVYKP-- 78
A GS A LES + P + ++ T S ++ ++ SPS P PP
Sbjct: 240 AAAGSQAAALESHPYGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPSLPSPPSRSSSSG 299
Query: 79 ---CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCR 135
C VC D ++ HYGV +CEGCKGFF+R++QKN Y C +KNC ++K RNRCQYCR
Sbjct: 300 EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCR 359
Query: 136 LQKCFEVGMSKEAVRNDR---------NKKKKEVKEEGSPDSYELSP--QLEELITKV-- 182
QKC VGM KE VR D +K K +++E S S P + L+ +
Sbjct: 360 FQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRALTD 419
Query: 183 SKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTG 242
S + C + + A+H Q F L T I +A+++PGFT
Sbjct: 420 STPRDLDYSRYCPTDQAAAGTDAEHVQQ--------FYNLLTASIDVSRSWAEKIPGFTD 471
Query: 243 LSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA 302
L DQ L+++A L++ +LR+ R +D F +GL L+R Q GFG D +
Sbjct: 472 LPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-GFGEWLDSIKD 530
Query: 303 FAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQP 362
F+ L L +D LSA+ +I +R L+EP++V++L + +L+ + + + +P
Sbjct: 531 FSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRVEELCNKITSSLKDHQSKGQALEP 589
Query: 363 YMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 404
++L + +LR I T G +R LK+E P +I ++
Sbjct: 590 -TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKL 630
>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 187 bits (474), Expect = 2e-47
Identities = 130/402 (32%), Positives = 199/402 (49%), Gaps = 37/402 (9%)
Query: 29 ATGGSCFAGLESFAWPQPASLQSVE--------TQSTSSEEMVPSSPSPPPPPRVYKP-- 78
A GS A LES + P + ++ T S ++ ++ SPS P PP
Sbjct: 229 AAAGSQAAALESHPYGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPSLPSPPSRSSSSG 288
Query: 79 ---CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCR 135
C VC D ++ HYGV +CEGCKGFF+R++QKN Y C +KNC ++K RNRCQYCR
Sbjct: 289 EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCR 348
Query: 136 LQKCFEVGMSKEAVRNDR---------NKKKKEVKEEGSPDSYELSP--QLEELITKV-- 182
QKC VGM KE VR D +K K +++E S S P + L+ +
Sbjct: 349 FQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRALTD 408
Query: 183 SKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTG 242
S + C + + A+H Q F L T I +A+++PGFT
Sbjct: 409 STPRDLDYSRYCPTDQAAAGTDAEHVQQ--------FYNLLTASIDVSRSWAEKIPGFTD 460
Query: 243 LSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA 302
L DQ L+++A L++ +LR+ R +D F +GL L+R Q GFG D +
Sbjct: 461 LPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-GFGEWLDSIKD 519
Query: 303 FAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQP 362
F+ L L +D LSA+ +I +R L+EP++V++L + +L+ + + + +P
Sbjct: 520 FSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRVEELCNKITSSLKDHQSKGQALEP 578
Query: 363 YMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 404
++L + +LR I T G +R LK+E P +I ++
Sbjct: 579 -TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKL 619
>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 187 bits (474), Expect = 2e-47
Identities = 130/402 (32%), Positives = 199/402 (49%), Gaps = 37/402 (9%)
Query: 29 ATGGSCFAGLESFAWPQPASLQSVE--------TQSTSSEEMVPSSPSPPPPPRVYKP-- 78
A GS A LES + P + ++ T S ++ ++ SPS P PP
Sbjct: 229 AAAGSQAAALESHPYGLPLAKRAAPLAFPPLGLTPSPTASSLLGESPSLPSPPSRSSSSG 288
Query: 79 ---CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCR 135
C VC D ++ HYGV +CEGCKGFF+R++QKN Y C +KNC ++K RNRCQYCR
Sbjct: 289 EGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCR 348
Query: 136 LQKCFEVGMSKEAVRNDR---------NKKKKEVKEEGSPDSYELSP--QLEELITKV-- 182
QKC VGM KE VR D +K K +++E S S P + L+ +
Sbjct: 349 FQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRALTD 408
Query: 183 SKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTG 242
S + C + + A+H Q F L T I +A+++PGFT
Sbjct: 409 STPRDLDYSRYCPTDQAAAGTDAEHVQQ--------FYNLLTASIDVSRSWAEKIPGFTD 460
Query: 243 LSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA 302
L DQ L+++A L++ +LR+ R +D F +GL L+R Q GFG D +
Sbjct: 461 LPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLR-GFGEWLDSIKD 519
Query: 303 FAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQP 362
F+ L L +D LSA+ +I +R L+EP++V++L + +L+ + + + +P
Sbjct: 520 FSLNLQSLNLDIQALACLSALSMIT-ERHGLKEPKRVEELCNKITSSLKDHQSKGQALEP 578
Query: 363 YMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 404
++L + +LR I T G +R LK+E P +I ++
Sbjct: 579 -TESKVLGALVELRKICTLGLQRIFYLKLEDLVSPPSIIDKL 619
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 186 bits (471), Expect = 5e-47
Identities = 137/412 (33%), Positives = 196/412 (47%), Gaps = 39/412 (9%)
Query: 17 GAAGPGAGLLRRATGGSCFAGLESFAWPQPASLQSVETQSTSSEEMVPSSPSPPPPPRVY 76
G GPG T G AG +P+ A S +S+ + P P +
Sbjct: 7 GWGGPGGD-----TNGVDKAG----GYPRAAEDDSASPPGAASD----AEPGDEERPGLQ 53
Query: 77 KPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRL 136
C VC DKSSG HYGV +CEGCK FF+RSI++N+ YTC +++C I++ RN+CQYCRL
Sbjct: 54 VDCVVCGDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRL 113
Query: 137 QKCFEVGMSKEAVRNDR---NKKKKEVKEEGSPDSYELS-----------PQLEELITKV 182
+KCF VGM KEAV+ R + GSP L+ + ELI ++
Sbjct: 114 KKCFRVGMRKEAVQRGRIPHSLPGAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQL 173
Query: 183 SKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTG 242
+A E +P+ G++ A V LG+ D ELA + + VE+A+ P F
Sbjct: 174 LRA--EPYPAAA--GRFGAGGGAAGAV---LGI-DNVCELAARLLFSTVEWARHAPFFPE 225
Query: 243 LSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA 302
L +ADQ+ LL+ + ++ +L P T L+ M D V A
Sbjct: 226 LPVADQVALLRLSWSELFVLNAAQAALP-LHTAPLLAAAGLHAAPMAAERAVAFMDQVRA 284
Query: 303 FAGQ---LLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRP 359
F Q L L++D E G L AI L D L +P V+ LQE AL Y R + P
Sbjct: 285 FQEQVDKLGRLQVDSAEYGCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYP 344
Query: 360 SQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMF 411
SQP F R+L+++ LR + + +++ P+ LIR+ML + F
Sbjct: 345 SQPQRFGRLLLRLPALRAVPASLISQLFFMRLVGKTPIETLIRDMLLSGSTF 396
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,545,735
Number of Sequences: 37866
Number of extensions: 1095510
Number of successful extensions: 9079
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 143
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 8326
Number of HSP's gapped (non-prelim): 572
length of query: 443
length of database: 18,247,518
effective HSP length: 105
effective length of query: 338
effective length of database: 14,271,588
effective search space: 4823796744
effective search space used: 4823796744
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.