Search of human proteins with 169166473

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169166473 PREDICTED: similar to hCG18094 [Homo sapiens]
         (459 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169166473 PREDICTED: similar to hCG18094 [Homo sapiens]            899   0.0  
gi|169167297 PREDICTED: similar to hCG18094 [Homo sapiens]            896   0.0  
gi|169166558 PREDICTED: similar to hCG18094 [Homo sapiens]            893   0.0  
gi|148746195 trichohyalin [Homo sapiens]                               73   6e-13
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    66   8e-11
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    66   8e-11
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    62   8e-10
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    60   4e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        60   4e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        60   4e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         60   4e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         60   4e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         60   4e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         60   4e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         60   4e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         60   4e-09
gi|219803769 trichoplein [Homo sapiens]                                59   7e-09
gi|14150056 trichoplein [Homo sapiens]                                 59   7e-09
gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]            59   1e-08
gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]            59   1e-08
gi|239744982 PREDICTED: hypothetical protein [Homo sapiens]            59   1e-08
gi|45439327 periplakin [Homo sapiens]                                  58   2e-08
gi|31982906 cingulin-like 1 [Homo sapiens]                             57   3e-08
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    57   3e-08
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    57   3e-08
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    57   3e-08
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    57   3e-08
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]         57   3e-08
gi|134152708 arginine and glutamate rich 1 [Homo sapiens]              56   8e-08
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    55   1e-07

>gi|169166473 PREDICTED: similar to hCG18094 [Homo sapiens]
          Length = 459

 Score =  899 bits (2323), Expect = 0.0
 Identities = 459/459 (100%), Positives = 459/459 (100%)

Query: 1   MPRSCRERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQ 60
           MPRSCRERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQ
Sbjct: 1   MPRSCRERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQ 60

Query: 61  ELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQ 120
           ELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQ
Sbjct: 61  ELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQ 120

Query: 121 ENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTV 180
           ENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTV
Sbjct: 121 ENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTV 180

Query: 181 QEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEM 240
           QEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEM
Sbjct: 181 QEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEM 240

Query: 241 SIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRW 300
           SIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRW
Sbjct: 241 SIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRW 300

Query: 301 EEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDWWE 360
           EEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDWWE
Sbjct: 301 EEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDWWE 360

Query: 361 EPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGGVPARADAFPGL 420
           EPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGGVPARADAFPGL
Sbjct: 361 EPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGGVPARADAFPGL 420

Query: 421 QAQLEAQHWLELERSRERRLQALQQGGSGPGPARRLEAA 459
           QAQLEAQHWLELERSRERRLQALQQGGSGPGPARRLEAA
Sbjct: 421 QAQLEAQHWLELERSRERRLQALQQGGSGPGPARRLEAA 459


>gi|169167297 PREDICTED: similar to hCG18094 [Homo sapiens]
          Length = 459

 Score =  896 bits (2315), Expect = 0.0
 Identities = 458/459 (99%), Positives = 458/459 (99%)

Query: 1   MPRSCRERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQ 60
           MPRSCRERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQ
Sbjct: 1   MPRSCRERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQ 60

Query: 61  ELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQ 120
           ELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQ
Sbjct: 61  ELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQ 120

Query: 121 ENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTV 180
           ENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTV
Sbjct: 121 ENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTV 180

Query: 181 QEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEM 240
           QEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEM
Sbjct: 181 QEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEM 240

Query: 241 SIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRW 300
           SIVELRERLALLKENQRRKEEEKRDQIIQGK TKSQELQNMVEQISLCRAAMGRSAALRW
Sbjct: 241 SIVELRERLALLKENQRRKEEEKRDQIIQGKRTKSQELQNMVEQISLCRAAMGRSAALRW 300

Query: 301 EEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDWWE 360
           EEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDWWE
Sbjct: 301 EEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDWWE 360

Query: 361 EPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGGVPARADAFPGL 420
           EPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGGVPARADAFPGL
Sbjct: 361 EPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGGVPARADAFPGL 420

Query: 421 QAQLEAQHWLELERSRERRLQALQQGGSGPGPARRLEAA 459
           QAQLEAQHWLELERSRERRLQALQQGGSGPGPARRLEAA
Sbjct: 421 QAQLEAQHWLELERSRERRLQALQQGGSGPGPARRLEAA 459


>gi|169166558 PREDICTED: similar to hCG18094 [Homo sapiens]
          Length = 459

 Score =  893 bits (2307), Expect = 0.0
 Identities = 456/459 (99%), Positives = 457/459 (99%)

Query: 1   MPRSCRERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQ 60
           MPRSCRERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQ
Sbjct: 1   MPRSCRERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQ 60

Query: 61  ELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQ 120
           ELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQ
Sbjct: 61  ELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQ 120

Query: 121 ENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTV 180
           ENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTV
Sbjct: 121 ENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTV 180

Query: 181 QEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEM 240
           QEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEM
Sbjct: 181 QEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEM 240

Query: 241 SIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRW 300
           SIVELRERLALLKENQRRKEEEKRDQIIQGK TKSQELQNMVEQISLCRAAMGRSAALRW
Sbjct: 241 SIVELRERLALLKENQRRKEEEKRDQIIQGKRTKSQELQNMVEQISLCRAAMGRSAALRW 300

Query: 301 EEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDWWE 360
           EEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDWWE
Sbjct: 301 EEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDWWE 360

Query: 361 EPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGGVPARADAFPGL 420
           EPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGGVPARAD+FPGL
Sbjct: 361 EPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGGVPARADSFPGL 420

Query: 421 QAQLEAQHWLELERSRERRLQALQQGGSGPGPARRLEAA 459
            AQLEAQHWLELERSRERRLQALQQGGSGPGPARRLEAA
Sbjct: 421 HAQLEAQHWLELERSRERRLQALQQGGSGPGPARRLEAA 459


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 65/295 (22%), Positives = 144/295 (48%), Gaps = 13/295 (4%)

Query: 49  REGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSH 108
           R+  ++Q + E+E ++ + ++    +  +  E Q++ + ++ EEQL   E + L+ +   
Sbjct: 233 RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE 292

Query: 109 EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
           EE    R    Q+ +++ E+++ +  +   ++ ERR +++  R++ + +  E ++  +  
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352

Query: 169 QTKLAKGRQQTVQEAIEESR--GLLQRRAQAAQEEQRRRCELISQLRAL--ETQPTRKGK 224
           + +  + R+Q ++   EE R    L+R  Q  +E+Q RR + + + + L  E Q  R+ +
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412

Query: 225 L---VDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNM 281
           L     L +      E E    E +      ++  +R++EE+RD + + + T+  E +  
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472

Query: 282 VEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQ 336
            +Q+   +    R   L+ EE++          Q+ R QQLRR   ER  +R ++
Sbjct: 473 KQQLKRDQEEERRERWLKLEEEE------RREQQERREQQLRREQEERREQRLKR 521



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 74/304 (24%), Positives = 139/304 (45%), Gaps = 44/304 (14%)

Query: 48  LREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLS 107
           LR     +R+ E+  +++ K  +      E  E + K + ++R +QL   E  R Q +L 
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591

Query: 108 HEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKA 167
            E+     Q L +E  +R+EQ+         +R E+RL+ +   +E  +Q+++ ++  + 
Sbjct: 592 REQEERLEQRLKREEVERLEQE---------ERREQRLKREEPEEERRQQLLKSEEQEER 642

Query: 168 AQTKLAKGRQQTVQEAI--EESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKL 225
            Q +L + +Q+  ++ +  EE    L++R +   EE+RR  EL     A E Q   + ++
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL-----AEEEQEQARERI 697

Query: 226 VDLTQIPGYGLEGE----MSIVELRERLALLKENQRRKEEE-----KRDQIIQGKHTKSQ 276
                   + LE E     S V  R R    +E QRR++E+     +R+  +Q +  +  
Sbjct: 698 KSRIPKWQWQLESEADARQSKVYSRPR---KQEGQRRRQEQEEKRRRRESELQWQEEERA 754

Query: 277 ELQNMVEQISLCRAAMGRSAALRW--EEK-----KALAAAPAAPSQDERVQQLRRRISER 329
             Q   E+         R    +W  EEK     + L+A P  P +++R +QLR    ++
Sbjct: 755 HRQQQEEE-------QRRDFTWQWQAEEKSERGRQRLSARP--PLREQRERQLRAEERQQ 805

Query: 330 AAER 333
             +R
Sbjct: 806 REQR 809



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 84/390 (21%), Positives = 162/390 (41%), Gaps = 54/390 (13%)

Query: 55  QRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLA 114
           Q + +Q+L+R D+  +    + +  E +++ Q + RE+QL   +  R + +L  +E    
Sbjct: 469 QERRKQQLKR-DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEER 527

Query: 115 RQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAK 174
            Q  ++  +Q   +Q+E+  +L+ +  E+RL ++R  + L  +  E +      + +  +
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ 587

Query: 175 GRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGY 234
            R +  QE   E R L +   +  ++E+RR      +L+  E +  R+ +L+   +    
Sbjct: 588 QRLKREQEERLEQR-LKREEVERLEQEERRE----QRLKREEPEEERRQQLLKSEE---- 638

Query: 235 GLEGEMSIVELRERLALLKEN--QRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAM 292
             + E    +LR      +E   +R +EEE+ +Q ++ +H + +  Q + E+        
Sbjct: 639 --QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696

Query: 293 GRSAALRWE---EKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTAR 349
            +S   +W+   E +A A      S+  + +  RRR  +    R R++ L      R  R
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR 756

Query: 350 PKPRVSPDWWEEPGRLKAGAGWGWRARRAGTGVPGRGWRGDRVRSAAGRYAAAGAGGGGG 409
            +        EE  R      W W+A                 +S  GR           
Sbjct: 757 QQQE------EEQRR---DFTWQWQAEE---------------KSERGR----------- 781

Query: 410 VPARADAFPGLQAQLEAQHWLELERSRERR 439
              R  A P L+ Q E Q   E  + RE+R
Sbjct: 782 --QRLSARPPLREQRERQLRAEERQQREQR 809



 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 69/356 (19%), Positives = 148/356 (41%), Gaps = 37/356 (10%)

Query: 7    ERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQV-EQELQRV 65
            +++Q  ++QL  + P + R+  +   YR +  L +     +  E    +RQ  E++ ++ 
Sbjct: 964  KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023

Query: 66   DKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQR 125
            D+L             ++++Q ++R+ +    E ++ + +L  EE    R+  ++   ++
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYR-EEEELQQEEEQLLGEERETRRRQELERQYRK 1082

Query: 126  VEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIE 185
             E+ +++  +L+ +  E+R R++R R+   E+ ++ Q+  +  + +  K R+Q ++    
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQ-QEEEQLLREEREKRRRQELERQYR 1141

Query: 186  ESRGLLQRRAQAAQE--EQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIV 243
            E   + Q   Q  +E  E+RRR EL  Q R                              
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYRE----------------------------- 1172

Query: 244  ELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWE-E 302
               E L   +E   R+E+EKR Q  + ++ + +ELQ    +              +WE E
Sbjct: 1173 --EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE 1230

Query: 303  KKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSPDW 358
            K+          +    +Q R+    +  +R  Q  L H+   +  R + +    W
Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 86/371 (23%), Positives = 146/371 (39%), Gaps = 49/371 (13%)

Query: 13   KQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQELQRVDKLVDGA 72
            +QQLR Q   R  +  +L    P+   ++       ++      Q EQ+L+R ++     
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550

Query: 73   GDFSEFFEWQKKMQAKDREEQLAASECRR-------------LQGKLSHEEAVLARQSLM 119
             D    F  +++++ +  E+QL+  E  R              + K   +E  L RQ   
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ 1610

Query: 120  QENKQ---------------RVEQQ----------KEQMAKLMLQRAERRLREDRSRKEL 154
            Q+ +Q               R EQQ           E+  +L  Q  E++LR DR RK  
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670

Query: 155  VEQVI--EGQKNAKAAQTKLAKGRQQTVQ-EAIEESRGLLQRRAQAAQEEQRRRCELISQ 211
             E+ +  EG++     Q +  K R++  Q    E  R  LQ   Q  ++E  R+     Q
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730

Query: 212  LR--ALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKE----NQRRKEEEKRD 265
            LR    + Q  R+ +   + +      E E   +  +ER    +E     Q R+E++ R 
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790

Query: 266  QIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRR 325
            Q    K  + ++L+   E+  L      R    RWEE++          + ER +Q R  
Sbjct: 1791 QESDRKFREEEQLRQEREEQQL--RPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAE 1848

Query: 326  ISERAAERSRQ 336
                  E+SR+
Sbjct: 1849 EQFATQEKSRR 1859



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 70/308 (22%), Positives = 133/308 (43%), Gaps = 42/308 (13%)

Query: 55  QRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLA 114
           Q + EQ L+R  +         E  +W K+ +  +R EQ    E R+ Q K   EE    
Sbjct: 440 QERREQRLKREQE---------ERRDWLKREEETERHEQ----ERRKQQLKRDQEEERRE 486

Query: 115 RQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAK 174
           R   ++E ++R +Q++ +     L+R +   RE R +++  E+ ++ +  ++    +  +
Sbjct: 487 RWLKLEEEERREQQERREQ---QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE 543

Query: 175 GRQQTVQEAIEESRGLLQRRAQAAQEEQR-RRCELISQLRALETQPTRKGKLVDLTQIPG 233
            R++ + +  EE R   +RR Q  + EQ  RR +L+ +      Q  ++ +         
Sbjct: 544 ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ--------- 594

Query: 234 YGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMG 293
              E  +     RE +  L++ +RR++  KR+   + +  + Q+L    EQ         
Sbjct: 595 ---EERLEQRLKREEVERLEQEERREQRLKRE---EPEEERRQQLLKSEEQ------EER 642

Query: 294 RSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPR 353
           R   LR E+++          ++ER++Q  +R  E   ER  Q            R K R
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKR--EHEEERREQELAEEEQEQARERIKSR 700

Query: 354 VSPDW-WE 360
           + P W W+
Sbjct: 701 I-PKWQWQ 707



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 63/302 (20%), Positives = 130/302 (43%), Gaps = 36/302 (11%)

Query: 55  QRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLA 114
           Q + EQ+L+R  +L              ++ Q   RE+QL   +  R + +L  E+ +  
Sbjct: 376 QLRREQQLRREQQL--------------RREQQLRREQQLRREQQLRREQQLRREQQLRR 421

Query: 115 RQSLMQENK--------------QRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIE 160
            Q L +E +              QR+++++E+    + +  E    E   RK+ +++  E
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481

Query: 161 GQKNAKAAQTKLAKGRQQ---TVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALET 217
            ++  +  + +  + R+Q     Q+   E     ++R +  +EE+R +  L S+ +    
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541

Query: 218 QPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQE 277
           Q  R+ +L  L +     LE E     L+      ++   ++EEE+R Q ++ +  +  E
Sbjct: 542 QEERREQL--LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599

Query: 278 LQNMVEQISLCRAAMGRSAALRW---EEKKALAAAPAAPSQDERVQQLRRRISERAAERS 334
            +   E++        R   L+    EE++      +   ++ R QQLRR   ER  +R 
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRL 659

Query: 335 RQ 336
           ++
Sbjct: 660 KR 661



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 67/294 (22%), Positives = 129/294 (43%), Gaps = 38/294 (12%)

Query: 56  RQVEQELQRVDKLVDGAGDFSEFFEWQKKM---------QAKDREEQLAASECRRLQGKL 106
           + V+  L+ +D   +G  DF+EF  +  K+         QA   +E+  A    R  GK 
Sbjct: 52  KTVDLILELLDLDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRA----RCDGK- 106

Query: 107 SHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAK 166
                    +SL+Q+ +Q  +Q++ +     L+  E   R  + R+E   ++ EG++ ++
Sbjct: 107 ---------ESLLQDRRQEEDQRRFEPRDRQLEE-EPGQRRRQKRQEQERELAEGEEQSE 156

Query: 167 AAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLV 226
             +    + RQ+  +E   + +   +R  + A+EEQ + C+        + +  R+ +L+
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216

Query: 227 DLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQIS 286
           +L +    G E +    + RER   + + +  KE  KR+ +++ +  K QE     E+  
Sbjct: 217 ELRR---KGREEKQQ--QRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE-----EEPQ 266

Query: 287 LCRAAMGRSAALRWEEKKALAAAPAAPSQDE----RVQQLRRRISERAAERSRQ 336
             R        LR  E++ L        Q +    R QQLRR+  E   E+  +
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 70/276 (25%), Positives = 125/276 (45%), Gaps = 35/276 (12%)

Query: 82   QKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRA 141
            +++   K REE+L   E    QG+   EE     Q L ++ ++R   ++EQ  +L  Q  
Sbjct: 1355 RQERDRKFREEELRHQE----QGRKFLEE----EQRLRRQERERKFLKEEQ--QLRCQER 1404

Query: 142  ERRLREDRSRK--ELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQ 199
            E++LR+DR RK  E  +Q+   +++ K  + +    RQ+  ++ +EE + L Q R +  +
Sbjct: 1405 EQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR 1464

Query: 200  EEQ-----------------RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSI 242
            EE+                 R+  E   QLR  E     + + +   +     LE E  +
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524

Query: 243  -VELRERLALLKENQRRKEE--EKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALR 299
              + R+R  L +E Q R++E  ++R Q    K  + ++L+   E+  L R    R    R
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR--QERDRKFR 1582

Query: 300  WEEKKALAAAPAAPSQDERVQQLRRRISERAAERSR 335
             EE+K           ++  QQLRR+  ++   + R
Sbjct: 1583 LEEQKVRRQEQERKFMEDE-QQLRRQEGQQQLRQER 1617



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 82/365 (22%), Positives = 148/365 (40%), Gaps = 59/365 (16%)

Query: 7    ERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQV-------E 59
            E VQ  ++QL  + P + R+      YR +  L +     +LRE    +RQ        E
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ-EEEQLLREEQEKRRQERERQYREE 1202

Query: 60   QELQRVDKLV-----DGAGDFSEFFEWQK-------KMQAKDREE----QLAASECRRLQ 103
            +ELQR  +       D   D    +E +K       K+  K RE     QL  S+ R  Q
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262

Query: 104  GKLSHEEAVLARQSLMQENKQRVEQQK-------EQMAKLMLQRAERRLREDRSRKELVE 156
             +   +  +  +Q   +E ++R  QQ+       EQ+ +   + A+RR R+ +  K+L+ 
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR 1322

Query: 157  QVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALE 216
            +  E ++            RQ+T ++  EE + L +R  Q  + ++R R     + R  E
Sbjct: 1323 EEREEKRR-----------RQETDRKFREEEQLLQEREEQPLRRQERDR-----KFREEE 1366

Query: 217  TQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQ 276
             +   +G+           LE E  +         LKE Q+ + +E+  Q+ Q +  K +
Sbjct: 1367 LRHQEQGRKF---------LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417

Query: 277  ELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQ 336
            E +  + +    R        +R +E++          + ER ++ R    E    + R+
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR---EEEQLLQERE 1474

Query: 337  AALLH 341
               LH
Sbjct: 1475 EQQLH 1479



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 70/315 (22%), Positives = 133/315 (42%), Gaps = 37/315 (11%)

Query: 41   KLNTTAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECR 100
            +L+    LRE    Q + E+  QR  + +       E  + Q++ Q ++RE++L   E  
Sbjct: 783  RLSARPPLREQRERQLRAEERQQREQRFLP-----EEEEKEQRRRQRREREKELQFLEEE 837

Query: 101  RLQGKLSHEEAVLARQSLMQENKQR---VEQQKEQMAKLMLQRAERRLR---------ED 148
                +    + +   +  +QE+++R    EQ+++Q  +  L+   +R R         ++
Sbjct: 838  EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897

Query: 149  RSRKE---LVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRR 205
            + RKE   L E+  E Q+  +  + +  + RQ   +E +++    L R     + E+RRR
Sbjct: 898  QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE----EREKRRR 953

Query: 206  CELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRD 265
             E   Q R  +    ++ +L+          E E    E  E     ++  R + E++R 
Sbjct: 954  QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013

Query: 266  QIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWE-EKKALAAAPAAPSQDERVQQLRR 324
            Q  + ++ K  ELQ   EQ+            LR E EK+ L        ++E +QQ   
Sbjct: 1014 QEWERQYRKKDELQQEEEQL------------LREEREKRRLQERERQYREEEELQQEEE 1061

Query: 325  RISERAAERSRQAAL 339
            ++     E  R+  L
Sbjct: 1062 QLLGEERETRRRQEL 1076



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 67/299 (22%), Positives = 126/299 (42%), Gaps = 50/299 (16%)

Query: 80   EWQKKMQAKDREEQLAASECR--RLQGKLSHEEAVLARQSLMQENKQRVEQQ-------K 130
            E ++++Q ++RE++    + R  R + +L  EE  L R+   +  +Q  E+Q       +
Sbjct: 908  EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967

Query: 131  EQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQ------------Q 178
            ++  +L+ +  E+R R++R +K   E+ ++ ++     + +  + RQ            Q
Sbjct: 968  QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ 1027

Query: 179  TVQEAI----EESRGLLQRRAQAAQEEQ---------------RRRCELISQLRALETQP 219
              +E +     E R L +R  Q  +EE+               RRR EL  Q R  E   
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087

Query: 220  TRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQ 279
              + +L+          E E    E  E     ++  R + E++R Q ++ ++ + +E+Q
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147

Query: 280  NMVEQISLCRAAMGRSAAL--RWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQ 336
               EQ+        R   L  ++ E++ L        Q E  Q LR    +R  ER RQ
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEEL--------QQEEEQLLREEQEKRRQERERQ 1198



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 70/304 (23%), Positives = 133/304 (43%), Gaps = 35/304 (11%)

Query: 41  KLNTTAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECR 100
           +L + A  R+  +Y R  +QE QR  +            E ++K + ++ E Q    E  
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQ------------EQEEKRRRRESELQWQEEERA 754

Query: 101 RLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIE 160
             Q +   +      Q   +E  +R  Q+      L  QR ER+LR +  ++   EQ   
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR-ERQLRAEERQQR--EQRFL 811

Query: 161 GQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPT 220
            ++  K  + +  + R++ +Q   EE +   + RAQ  QEE+    E   + R+ E +  
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871

Query: 221 RKGK--LVDLTQIPGYGLEGEMSIVE-LRERLALLKEN----QRRKEEEKRDQIIQGKHT 273
           +K +  L +  +   + L  + ++ E LR+   LL+E     QR + E++R Q  + ++ 
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR 931

Query: 274 KSQELQNMVEQISLCRAAMGRSAALRWE-EKKALAAAPAAPSQDERVQQLRRRISERAAE 332
           + ++LQ   EQ+            LR E EK+          +D+++QQ   ++     E
Sbjct: 932 EEEQLQQEEEQL------------LREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979

Query: 333 RSRQ 336
           + R+
Sbjct: 980 KRRR 983



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 38/159 (23%), Positives = 78/159 (49%), Gaps = 14/159 (8%)

Query: 47   ILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKL 106
            IL E  L   + EQ+L+R ++           F  +++++ +  E+QL + E  R   K 
Sbjct: 1749 ILEEEQLRPEREEQQLRRQER--------DRKFREEEQLRQEREEQQLRSQESDR---KF 1797

Query: 107  SHEEAVLARQSLMQ-ENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNA 165
              EE +   +   Q   +QR  + + +  +L L+  E+RLR++R R+   E+    Q+ +
Sbjct: 1798 REEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKS 1857

Query: 166  KAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRR 204
            +  + +L +  +Q  ++  E  R L +   +  Q+E++R
Sbjct: 1858 RREEQELWQEEEQKRRQ--ERERKLREEHIRRQQKEEQR 1894



 Score = 38.1 bits (87), Expect = 0.017
 Identities = 43/172 (25%), Positives = 82/172 (47%), Gaps = 23/172 (13%)

Query: 8    RVQGSKQQLRLQFPPR-IRKTPKLTFYRPDNILVKLNTTAILREGA-LYQRQVEQELQRV 65
            R +  +QQLR Q   R  R+  +L   R +  L    +    RE   L Q + EQ+L+  
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815

Query: 66   DKLVDGAGDFSEFFEWQKK-MQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQ 124
             +  DG       + W+++ +Q +++E++L     R+ +      E   A Q   +  +Q
Sbjct: 1816 QR--DGK------YRWEEEQLQLEEQEQRLRQERDRQYRA-----EEQFATQEKSRREEQ 1862

Query: 125  RVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGR 176
             + Q++EQ  +   Q  ER+LRE+  R++  E+    Q++ +  + K  +G+
Sbjct: 1863 ELWQEEEQKRR---QERERKLREEHIRRQQKEE----QRHRQVGEIKSQEGK 1907


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 78/319 (24%), Positives = 148/319 (46%), Gaps = 52/319 (16%)

Query: 58  VEQELQRVDKLVDGAGDFSEFFEWQKKMQAKD-REEQLAASECRRLQG-KLSHEEAVLAR 115
           VE+E QR++ L             ++K +A+  R +++   + RRL+  KL  EE    R
Sbjct: 535 VEKERQRLENL-------------RRKEEAEQLRRQKVEEDKRRRLEEVKLKREE----R 577

Query: 116 QSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKG 175
              + + ++RVEQ KE+  K + Q+  +   ++++ K   E++ E +   KAA  K+ + 
Sbjct: 578 LRKVLQARERVEQMKEEKKKQIEQKFAQI--DEKTEKAKEERLAEEKAKKKAAAKKMEEV 635

Query: 176 RQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYG 235
             +  QE  EE+R L   R    +EE+RR  EL+ + +  E +  RK       +     
Sbjct: 636 EARRKQE--EEARRL---RWLQQEEEERRHQELLQKKKEEEQERLRKA-----AEAKRLA 685

Query: 236 LEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRS 295
            + E    E +ER    +  Q R+E+E+R+   Q +    QE +   E++   R    R 
Sbjct: 686 EQREQERRE-QERREQERREQERREQERRE---QERQLAEQERRREQERLQAERELQERE 741

Query: 296 AALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAA----LLHVS-------- 343
            ALR ++++          ++E+ +   R++ E   +++++AA     L+V+        
Sbjct: 742 KALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPAC 801

Query: 344 -----APRTARPKPRVSPD 357
                 P+  R  P+++PD
Sbjct: 802 TSYQMTPQGHRAPPKINPD 820


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 70/306 (22%), Positives = 139/306 (45%), Gaps = 48/306 (15%)

Query: 84  KMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQR----VEQQKEQMAKLMLQ 139
           +M  K++E Q       RL+     EEA   R+  ++E+K+R    V+ ++E+  + +LQ
Sbjct: 527 RMDPKEKERQ-------RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQ 579

Query: 140 RAERRLREDRSRKELVEQVIE--GQKNAKAAQTKLA--KGRQQTVQEAIEESRGLLQRRA 195
             ER  +    +K+ +EQ      +K  KA + +LA  K +++   + +EE     ++  
Sbjct: 580 ARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE 639

Query: 196 QAA-------QEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRER 248
           +A        +EE+RR  EL+ + +  E +  RK       +      + E    E +ER
Sbjct: 640 EARRLRWLQQEEEERRHQELLQKKKEEEQERLRKA-----AEAKRLAEQREQERRE-QER 693

Query: 249 LALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAA 308
               +  Q R+E+E+R+   Q +    QE +   E++   R    R  ALR ++++    
Sbjct: 694 REQERREQERREQERRE---QERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRE 750

Query: 309 APAAPSQDERVQQLRRRISERAAERSRQAA----LLHVS-------------APRTARPK 351
                 ++E+ +   R++ E   +++++AA     L+V+              P+  R  
Sbjct: 751 LEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAP 810

Query: 352 PRVSPD 357
           P+++PD
Sbjct: 811 PKINPD 816



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 58/229 (25%), Positives = 108/229 (47%), Gaps = 29/229 (12%)

Query: 82  QKKMQAKDREEQLAASECRRLQGKLSH--EEAVLARQSLMQENKQRVEQQKEQMAKLMLQ 139
           +K +QA++R EQ+   + ++++ K +   E+   A++  + E K + +   ++M ++  +
Sbjct: 575 RKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR 634

Query: 140 RAE----RRLR------EDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRG 189
           R +    RRLR      E+R  +EL+++  E ++       +  +  +Q  QE  E+ R 
Sbjct: 635 RKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERR 694

Query: 190 LLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERL 249
             +RR Q  +E++RR      Q R L  Q  R+ +           L+ E  + E  + L
Sbjct: 695 EQERREQERREQERR-----EQERQLAEQERRREQ---------ERLQAERELQEREKAL 740

Query: 250 ALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAAL 298
            L KE  +R+ EEK+    + +  +  E Q   EQ    + A G S AL
Sbjct: 741 RLQKEQLQRELEEKKK---KEEQQRLAERQLQEEQEKKAKEAAGASKAL 786



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 49/206 (23%), Positives = 93/206 (45%), Gaps = 16/206 (7%)

Query: 6   RERVQGSKQQLRLQFPPRI----RKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQE 61
           RERV+  K++ + Q   +      KT K    R      K    A   E    +R+ E+E
Sbjct: 581 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 640

Query: 62  LQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQ---LAASECRRLQGKLSHEEAVLARQSL 118
            +R+  L        E    Q+ +Q K  EEQ     A+E +RL  +   E     R+  
Sbjct: 641 ARRLRWLQQE----EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQ 696

Query: 119 MQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQ 178
            +  ++R EQ++ +  +   Q AE+  R ++ R +   ++ E +K  +  + +L +  ++
Sbjct: 697 ERREQERREQERREQER---QLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEE 753

Query: 179 TVQEAIEESRGLLQRRAQAAQEEQRR 204
             ++  EE + L +R+ Q  QE++ +
Sbjct: 754 KKKK--EEQQRLAERQLQEEQEKKAK 777


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 55/283 (19%), Positives = 131/283 (46%), Gaps = 41/283 (14%)

Query: 56  RQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASE--CRRLQGKLSHEEAVL 113
           R+ E++++R ++++           W+K+ + + +EE +   E   R L+ K+  +E + 
Sbjct: 312 REQEEKMRRQEEMM-----------WEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIR 360

Query: 114 ARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLA 173
            ++   QE ++  EQ+K Q  +  + R E ++RE   +    E++++ Q+     Q +  
Sbjct: 361 EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 420

Query: 174 KGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPG 233
             +++ +QE  E+ R    R+ +  +E++++  E   ++R  E     + + +       
Sbjct: 421 WEQEEEMQEQEEKMR----RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMG------ 470

Query: 234 YGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMG 293
              E E  + E   ++   +E  RR+EE+ R+Q         ++++   E+I      M 
Sbjct: 471 ---EQEGKMCEQEAKMQEQEEKMRRQEEKIREQ--------EKKIREQEEKIREQEEMMQ 519

Query: 294 RSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQ 336
                 WE+++ +        Q+E++Q+   ++  R  E+ R+
Sbjct: 520 EQEEKMWEQEEKMC------EQEEKMQEQEEKM-RRQEEKMRE 555



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 47/221 (21%), Positives = 116/221 (52%), Gaps = 15/221 (6%)

Query: 56  RQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLAR 115
           R++E+++   +K+ +      E    ++K++ +++ ++  A   R+ +     EE +  +
Sbjct: 347 RELEEKMHEQEKIREQEEKRQE----EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 402

Query: 116 QSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKG 175
           + +MQE ++++ +Q+E+M +   Q  E + +E++ R++  E++ E +K  +  + K+ + 
Sbjct: 403 EEMMQEQEEKMGEQEEKMWE---QEEEMQEQEEKMRRQ-EEKIREQEKKIREQEEKIREQ 458

Query: 176 RQ--QTVQEAIEESRGLL---QRRAQAAQEEQRRRCELI-SQLRALETQPTRKGKLVDLT 229
            +  Q  +E + E  G +   + + Q  +E+ RR+ E I  Q + +  Q  +  +  ++ 
Sbjct: 459 EEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518

Query: 230 QIPGYGL-EGEMSIVELRERLALLKENQRRKEEEKRDQIIQ 269
           Q     + E E  + E  E++   +E  RR+EE+ R+Q ++
Sbjct: 519 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVR 559



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 60/298 (20%), Positives = 133/298 (44%), Gaps = 35/298 (11%)

Query: 53  LYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKL-SHEEA 111
           L Q+Q++ E   + K         E      K+QA+  E +L     ++ + K+   EE 
Sbjct: 246 LPQQQLQAEADHLGK---------ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 296

Query: 112 VLARQSLMQENKQRVEQQKEQMAK---LMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
           +  R+  +QE ++++ +Q+E+M +   +M ++ E+  R++    E  E++ E ++     
Sbjct: 297 IQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 356

Query: 169 QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCE---LISQLRALETQPTRKGKL 225
           +    +  ++  +E I E     ++ A+  ++E++ R +   +  Q   ++ Q  + G  
Sbjct: 357 EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMG-- 414

Query: 226 VDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQ--IIQGKHTKSQELQNMVE 283
                      E E  + E  E +   +E  RR+EE+ R+Q   I+ +  K +E + M++
Sbjct: 415 -----------EQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 463

Query: 284 QISLCRAAMGRSAALRWE-EKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
           +       MG       E E K          Q+E++++  ++I E+  +   Q  ++
Sbjct: 464 E---QEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 50/274 (18%), Positives = 123/274 (44%), Gaps = 25/274 (9%)

Query: 82  QKKMQAK-DREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQR 140
           Q+++QA+ D   +   S   +LQ ++   E +  R +  QE K   +++K Q  +  +Q 
Sbjct: 248 QQQLQAEADHLGKELQSVSAKLQAQVEENE-LWNRLNQQQEEKMWRQEEKIQEREEKIQE 306

Query: 141 AERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQE 200
            E ++RE   +    E+++  ++     Q ++   +++ ++E  E+    +  + +  ++
Sbjct: 307 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK----MHEQEKIREQ 362

Query: 201 EQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKE 260
           E++R+ E   ++R  E +  ++ K+             E  I E  E++   +E   +++
Sbjct: 363 EEKRQEE--EKIREQEKRQEQEAKM----------WRQEEKIREQEEKIRE-QEEMMQEQ 409

Query: 261 EEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQ 320
           EEK  +  +    + +E+Q   E++        +   +R +EKK          Q+E +Q
Sbjct: 410 EEKMGEQEEKMWEQEEEMQEQEEKMRR------QEEKIREQEKKIREQEEKIREQEEMMQ 463

Query: 321 QLRRRISERAAERSRQAALLHVSAPRTARPKPRV 354
           +   ++ E+  +   Q A +     +  R + ++
Sbjct: 464 EQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKI 497



 Score = 36.2 bits (82), Expect = 0.064
 Identities = 24/106 (22%), Positives = 57/106 (53%), Gaps = 8/106 (7%)

Query: 55  QRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKL-SHEEAVL 113
           + Q E   ++ +K+ +  G   +  E + KMQ ++ + +    + R  + K+   EE + 
Sbjct: 456 REQEEMMQEQEEKMGEQEG---KMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512

Query: 114 ARQSLMQENKQRVEQQKEQMA----KLMLQRAERRLREDRSRKELV 155
            ++ +MQE ++++ +Q+E+M     K+  Q  + R +E++ R++ V
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEV 558


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 65/334 (19%), Positives = 150/334 (44%), Gaps = 25/334 (7%)

Query: 48  LREGALYQRQVEQELQRVDKLV---DGAGDFSEFFEWQKKMQAKDREEQLAASE--CRRL 102
           +RE     R+ E++++R ++++   +      E   W+K+ + + +EE +   E   R L
Sbjct: 384 IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL 443

Query: 103 QGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLRED----RSRKELV--- 155
           + K+  +E +  ++   QE ++  EQ+K Q  +  + R E ++RE     R ++E +   
Sbjct: 444 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ 503

Query: 156 EQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRAL 215
           E+ I  Q+  +  + +  +      +E I E   + +++ +  ++E++ R +     R  
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQE 563

Query: 216 ETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEE---EKRDQIIQGKH 272
           E    ++ K+ +  +        E  I E  E++   +E  R +EE   E+ +++ + + 
Sbjct: 564 EKMHDQEEKIREQEE---KVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEE 620

Query: 273 TKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAE 332
              ++ + M EQ    R    +   +R +EKK          Q+E +Q+   ++ E+  +
Sbjct: 621 KMCEQEEKMQEQEEKMRR---QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 677

Query: 333 RSRQAALLHVSAPRTARPKPRVSPDWWEEPGRLK 366
              Q   +     +  R + ++    WE+  RL+
Sbjct: 678 MCEQEEKMQEQEEKMRRQEEKM----WEQEVRLR 707



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 66/375 (17%), Positives = 158/375 (42%), Gaps = 54/375 (14%)

Query: 9   VQGSKQQLRLQFPPRIRKTPKLTFYRPDNIL-------------VKLNTTAILREGALYQ 55
           V+  K +++L      RK  +     P   L             V     A + E  L+ 
Sbjct: 294 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 353

Query: 56  R---QVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAV 112
           R   Q E+++ R ++ +          EW++K+Q  ++EE++     R  + K+  +E  
Sbjct: 354 RLNQQQEEKMWRQEEKIQ---------EWEEKIQ--EQEEKI-----REQEEKIREQEEK 397

Query: 113 LARQ-SLMQENKQRVEQQKEQM--AKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQ 169
           + RQ  +M E ++++ +Q+E M   +  ++R E  + E   +   +E+ +  Q+  +  +
Sbjct: 398 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 457

Query: 170 TKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLT 229
            K  +  +   QE  +E    + R+ +  +E++ +  E   ++   E +   + K+ +  
Sbjct: 458 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEE 517

Query: 230 QIPGYGLEGEMSIVE--LRERLALLKENQR--------RKEEEKRDQIIQGKHTKSQELQ 279
           +      + EM   E  +RE+  + ++ ++        RK+EEK  +  +  H + ++++
Sbjct: 518 KRQE---QEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIR 574

Query: 280 NMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAAL 339
              E++        +   +R +E+K          Q+E  Q+   ++ E+  +   Q   
Sbjct: 575 EQEEKV------WRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 628

Query: 340 LHVSAPRTARPKPRV 354
           +     +  R + ++
Sbjct: 629 MQEQEEKMRRQEEKI 643



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 30/163 (18%), Positives = 75/163 (46%), Gaps = 12/163 (7%)

Query: 7   ERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQRQVEQELQRVD 66
           E++   ++++R Q     R+  K+   R     ++     I  +  + Q Q E+  ++ +
Sbjct: 564 EKMHDQEEKIREQEEKVWRQEEKI---REQEEKIREQEEKIREQEEMTQEQEEKMGEQEE 620

Query: 67  KLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRV 126
           K+ +      E  E  ++ + K RE++    E          EE +  ++ +MQE ++++
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE---------QEEKIREQEEMMQEQEEKM 671

Query: 127 EQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQ 169
            +Q+E+M +   +  E+  +  R  +++ EQ +  ++  +  Q
Sbjct: 672 WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 43/253 (16%), Positives = 95/253 (37%), Gaps = 32/253 (12%)

Query: 142 ERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEE 201
           E+ L    ++K+  ++ IE     + A + L   R     E ++E    LQ + Q  + E
Sbjct: 239 EQALSAVATQKKKADRYIEELTKERDALS-LELYRNTITDEELKEKNAKLQEKLQLVESE 297

Query: 202 QRR-------------RCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRER 248
           +               R +L+   + L+ +    GK +   Q     L+ ++   EL  R
Sbjct: 298 KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL---QSVSAKLQAQVEENELWNR 354

Query: 249 LALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWE------- 301
           L   +E +  ++EEK  +  +    + ++++   E+I      M R   + WE       
Sbjct: 355 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 414

Query: 302 --------EKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPR 353
                   E+K          ++E++++L  ++ E+   R ++         R    +  
Sbjct: 415 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 474

Query: 354 VSPDWWEEPGRLK 366
                W +  +++
Sbjct: 475 QEAKMWRQEEKIR 487


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 83/341 (24%), Positives = 149/341 (43%), Gaps = 50/341 (14%)

Query: 6    RERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQR--------- 56
            ++R   + ++LRLQ     R+  +    R   + V L T     E  L  +         
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREE--------QLAASECRRLQGKLSH 108
            Q+E+ LQ     V    + +E    Q+    + REE        QL A+E  RL  +L  
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RLQA 1648

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
            EE V  ++SL Q   ++ +++ E+ A+   +  E+ +R+    +EL EQ +E Q+     
Sbjct: 1649 EE-VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ----RELAEQELEKQR----- 1698

Query: 169  QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC--ELISQLRALETQPTRKGKLV 226
              +LA+G   T Q+ +   + L++ RA+  Q EQ+R+   E +++L+      T+K +  
Sbjct: 1699 --QLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ-- 1751

Query: 227  DLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQIS 286
                      E E  + ++R  + +L  ++ R EEE R    + K     E     E   
Sbjct: 1752 ----------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801

Query: 287  LCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRIS 327
               AA  R+ A   + ++ LA   AA  + E  + L  +++
Sbjct: 1802 --EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 60/248 (24%), Positives = 113/248 (45%), Gaps = 28/248 (11%)

Query: 119  MQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQ 178
            + E  +R+E++ E++A+        RL E  +  E   Q+ E    AKA   + AK  QQ
Sbjct: 1337 ISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395

Query: 179  TVQEAI---EESRGLLQRRAQAAQEE---QRRRCELISQLRALETQPTRKGKL------- 225
             +QE +   EE+    Q++ ++ QEE    R+  E   Q +A + +   + +L       
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455

Query: 226  -----VDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQN 280
                 ++ T+    G EGE+  +  R   A  ++ Q ++E E+  + +Q +  + ++   
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--- 1512

Query: 281  MVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
               ++ L       + A R E+++AL A      Q E  +   RR+ +   ER+RQ  + 
Sbjct: 1513 --AEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAE---RRLRQAEVERARQVQVA 1566

Query: 341  HVSAPRTA 348
              +A R+A
Sbjct: 1567 LETAQRSA 1574



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/350 (22%), Positives = 149/350 (42%), Gaps = 62/350 (17%)

Query: 45   TAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFE-----WQKKMQAKDREEQLAASEC 99
            T +  E  L Q+Q E   ++  +L +     ++        +Q+ ++A+ + +   ++E 
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382

Query: 100  RRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAK------------------LMLQRA 141
             RL+ +++      AR    +E+ QR  +Q E++ +                  L +QR 
Sbjct: 2383 ERLKLRVAEMSRAQARA---EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2439

Query: 142  E-----RRLRE-----DRSRKELVEQV----IEGQKNAKAAQTKLAKGRQQTVQEAIEES 187
            +      RLRE     +R +++L ++     ++ ++     Q +L +  Q   Q  + E 
Sbjct: 2440 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499

Query: 188  RGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRE 247
              LLQR  +   E+++ + E + Q    + Q  R+ +     Q+         S+ E R 
Sbjct: 2500 DSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557

Query: 248  RLALLKENQRRKEEEKR---DQIIQGKHTKSQELQNMVEQISLC----RAAMGRSAALRW 300
            R    +E  RRK+EE +    Q  Q +   ++E Q + EQ+ L     RAA+  S  +  
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617

Query: 301  EEKKALAA---------APAAPSQDER-VQQLRRRISERAAERSRQAALL 340
             +  A             PAA ++ E     LRR++S   A+R ++A +L
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGIL 2664



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 78/327 (23%), Positives = 141/327 (43%), Gaps = 38/327 (11%)

Query: 48   LREGALYQRQVEQE---LQRVDK---LVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR 101
            L E A  QRQ+ +E    QR +    L +      E    + + +   +E++      RR
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1868

Query: 102  LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR--LRED--RSRKELVEQ 157
            L    + +   L  Q+   ++K  +E++  Q+ K      ER+  L ED  R R+++ E+
Sbjct: 1869 LAEDEAFQRRRLEEQAA--QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926

Query: 158  VIEGQKN-----AKAAQTKLAKGR-----QQTVQEAIEESRGLLQRRAQAAQEEQRRR-- 205
            ++  + +     A  A+ +L  GR     + T++   +      ++R  AA+EE+RRR  
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986

Query: 206  CELISQLRALETQPT--RKGKLVDLTQIPGYGLEG----EMSIVELRERLALLKENQRRK 259
             E + +  A E +    RK  L ++ ++     E     E +  E   +L L +E  +++
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046

Query: 260  EEEKRDQIIQGKHTKSQELQNMVEQISLC------RAAMGRSAALRWEEKKALAAAPAAP 313
             + +          K QELQ  ++Q           A   R AA   EE +  A   AA 
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106

Query: 314  S--QDERVQQLRRRISERAAERSRQAA 338
            S  Q E  ++L++   E+A  R++  A
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQA 2133



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 59/261 (22%), Positives = 116/261 (44%), Gaps = 22/261 (8%)

Query: 86   QAKDREEQLAASECRRLQGKL-SHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR 144
            QAK + E+ A    +R+Q ++   EEA +  Q   +  ++ ++Q ++     +  +A + 
Sbjct: 1381 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440

Query: 145  LREDRSRKELVEQ--VIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ 202
               +RSR  + E+  V+  Q  A   Q   A+G  Q ++   EE+     ++ QA +E +
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAE 1497

Query: 203  RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEE 262
            R R ++       E+Q  R+ ++   +++     + E      ++R     E  R + EE
Sbjct: 1498 RLRRQVQD-----ESQRKRQAEVELASRV-----KAEAEAAREKQRALQALEELRLQAEE 1547

Query: 263  KRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQL 322
               ++ Q +  +++++Q  +E       A  +S    + EK A     +   +   V QL
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSLQEEHVAVAQL 1606

Query: 323  RRRISERA-----AERSRQAA 338
            R     RA     AER+R+ A
Sbjct: 1607 REEAERRAQQQAEAERAREEA 1627



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 61/290 (21%), Positives = 120/290 (41%), Gaps = 23/290 (7%)

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQK---KMQAKDREEQLAASECRRLQGKLSHEEAVL 113
            QVEQEL  +   ++         + +    K +A +   Q +  E      ++  EE   
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242

Query: 114  ARQSLMQENKQRVEQQKEQMAKLMLQRAE--RRLREDRSRKELVEQ--------VIEGQK 163
             +  +  EN+  + + K+   + + + AE  +++ E+ +R  +  Q          E   
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302

Query: 164  NAKAAQTKLAKGRQQTVQEA--IEESRGLLQRRAQAAQEEQRR---RCELISQLRALETQ 218
              +A   K+ K + Q VQEA  ++    LLQ++ + AQE+ RR     E ++Q  A ETQ
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362

Query: 219  PTRKGKLVDLTQIPGYGLEGE---MSIVELRERLALLKENQR--RKEEEKRDQIIQGKHT 273
              ++    +  +      E E   + + E+    A  +E+ +  RK+ E+  + +     
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2422

Query: 274  KSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLR 323
             +QE   +V+ + + R      A    E    L        Q+ ++ QL+
Sbjct: 2423 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 73/342 (21%), Positives = 139/342 (40%), Gaps = 61/342 (17%)

Query: 46   AILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR---- 101
            A   + A  + ++E EL R+    +      E    Q +++A  R+ QLAA E RR    
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKE----QAELEAA-RQRQLAAEEERRRREA 1986

Query: 102  ---LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQV 158
               +Q  L+ EE    ++    E  +R++ + E+  +L  +  +   R+ +  +E  ++ 
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046

Query: 159  IEGQKNAKA-AQTKLAKGRQQTVQE---AIEESRGLLQRRAQAAQEEQRRRCELISQLRA 214
            ++ ++ A A A  +  +  QQT+Q+    +++ RG  +   +AA+E +  R +   +   
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106

Query: 215  LETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTK 274
               Q                        VE  ERL        ++  E++ Q        
Sbjct: 2107 SRRQ------------------------VEEAERL--------KQSAEEQAQARAQAQAA 2134

Query: 275  SQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERS 334
            +++L+   EQ    R A    AALR ++        AA ++ E+ ++   +   + A+  
Sbjct: 2135 AEKLRKEAEQ-EAARRAQAEQAALRQKQ--------AADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 335  RQAALLHVSAPRTARPKPRVSPDWWEEPGRLKAGAGWGWRAR 376
            ++   L +    T   K  +     EE  RLKA A    R R
Sbjct: 2186 QELTTLRLQLEETDHQKNLLD----EELQRLKAEATEAARQR 2223


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 83/341 (24%), Positives = 149/341 (43%), Gaps = 50/341 (14%)

Query: 6    RERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQR--------- 56
            ++R   + ++LRLQ     R+  +    R   + V L T     E  L  +         
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1594

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREE--------QLAASECRRLQGKLSH 108
            Q+E+ LQ     V    + +E    Q+    + REE        QL A+E  RL  +L  
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RLQA 1652

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
            EE V  ++SL Q   ++ +++ E+ A+   +  E+ +R+    +EL EQ +E Q+     
Sbjct: 1653 EE-VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ----RELAEQELEKQR----- 1702

Query: 169  QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC--ELISQLRALETQPTRKGKLV 226
              +LA+G   T Q+ +   + L++ RA+  Q EQ+R+   E +++L+      T+K +  
Sbjct: 1703 --QLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ-- 1755

Query: 227  DLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQIS 286
                      E E  + ++R  + +L  ++ R EEE R    + K     E     E   
Sbjct: 1756 ----------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805

Query: 287  LCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRIS 327
               AA  R+ A   + ++ LA   AA  + E  + L  +++
Sbjct: 1806 --EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 60/248 (24%), Positives = 113/248 (45%), Gaps = 28/248 (11%)

Query: 119  MQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQ 178
            + E  +R+E++ E++A+        RL E  +  E   Q+ E    AKA   + AK  QQ
Sbjct: 1341 ISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1399

Query: 179  TVQEAI---EESRGLLQRRAQAAQEE---QRRRCELISQLRALETQPTRKGKL------- 225
             +QE +   EE+    Q++ ++ QEE    R+  E   Q +A + +   + +L       
Sbjct: 1400 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1459

Query: 226  -----VDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQN 280
                 ++ T+    G EGE+  +  R   A  ++ Q ++E E+  + +Q +  + ++   
Sbjct: 1460 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--- 1516

Query: 281  MVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
               ++ L       + A R E+++AL A      Q E  +   RR+ +   ER+RQ  + 
Sbjct: 1517 --AEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAE---RRLRQAEVERARQVQVA 1570

Query: 341  HVSAPRTA 348
              +A R+A
Sbjct: 1571 LETAQRSA 1578



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/350 (22%), Positives = 149/350 (42%), Gaps = 62/350 (17%)

Query: 45   TAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFE-----WQKKMQAKDREEQLAASEC 99
            T +  E  L Q+Q E   ++  +L +     ++        +Q+ ++A+ + +   ++E 
Sbjct: 2327 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2386

Query: 100  RRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAK------------------LMLQRA 141
             RL+ +++      AR    +E+ QR  +Q E++ +                  L +QR 
Sbjct: 2387 ERLKLRVAEMSRAQARA---EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2443

Query: 142  E-----RRLRE-----DRSRKELVEQV----IEGQKNAKAAQTKLAKGRQQTVQEAIEES 187
            +      RLRE     +R +++L ++     ++ ++     Q +L +  Q   Q  + E 
Sbjct: 2444 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2503

Query: 188  RGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRE 247
              LLQR  +   E+++ + E + Q    + Q  R+ +     Q+         S+ E R 
Sbjct: 2504 DSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561

Query: 248  RLALLKENQRRKEEEKR---DQIIQGKHTKSQELQNMVEQISLC----RAAMGRSAALRW 300
            R    +E  RRK+EE +    Q  Q +   ++E Q + EQ+ L     RAA+  S  +  
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621

Query: 301  EEKKALAA---------APAAPSQDER-VQQLRRRISERAAERSRQAALL 340
             +  A             PAA ++ E     LRR++S   A+R ++A +L
Sbjct: 2622 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGIL 2668



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 78/327 (23%), Positives = 141/327 (43%), Gaps = 38/327 (11%)

Query: 48   LREGALYQRQVEQE---LQRVDK---LVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR 101
            L E A  QRQ+ +E    QR +    L +      E    + + +   +E++      RR
Sbjct: 1813 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1872

Query: 102  LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR--LRED--RSRKELVEQ 157
            L    + +   L  Q+   ++K  +E++  Q+ K      ER+  L ED  R R+++ E+
Sbjct: 1873 LAEDEAFQRRRLEEQAA--QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930

Query: 158  VIEGQKN-----AKAAQTKLAKGR-----QQTVQEAIEESRGLLQRRAQAAQEEQRRR-- 205
            ++  + +     A  A+ +L  GR     + T++   +      ++R  AA+EE+RRR  
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1990

Query: 206  CELISQLRALETQPT--RKGKLVDLTQIPGYGLEG----EMSIVELRERLALLKENQRRK 259
             E + +  A E +    RK  L ++ ++     E     E +  E   +L L +E  +++
Sbjct: 1991 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2050

Query: 260  EEEKRDQIIQGKHTKSQELQNMVEQISLC------RAAMGRSAALRWEEKKALAAAPAAP 313
             + +          K QELQ  ++Q           A   R AA   EE +  A   AA 
Sbjct: 2051 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2110

Query: 314  S--QDERVQQLRRRISERAAERSRQAA 338
            S  Q E  ++L++   E+A  R++  A
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQA 2137



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 59/261 (22%), Positives = 116/261 (44%), Gaps = 22/261 (8%)

Query: 86   QAKDREEQLAASECRRLQGKL-SHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR 144
            QAK + E+ A    +R+Q ++   EEA +  Q   +  ++ ++Q ++     +  +A + 
Sbjct: 1385 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1444

Query: 145  LREDRSRKELVEQ--VIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ 202
               +RSR  + E+  V+  Q  A   Q   A+G  Q ++   EE+     ++ QA +E +
Sbjct: 1445 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAE 1501

Query: 203  RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEE 262
            R R ++       E+Q  R+ ++   +++     + E      ++R     E  R + EE
Sbjct: 1502 RLRRQVQD-----ESQRKRQAEVELASRV-----KAEAEAAREKQRALQALEELRLQAEE 1551

Query: 263  KRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQL 322
               ++ Q +  +++++Q  +E       A  +S    + EK A     +   +   V QL
Sbjct: 1552 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSLQEEHVAVAQL 1610

Query: 323  RRRISERA-----AERSRQAA 338
            R     RA     AER+R+ A
Sbjct: 1611 REEAERRAQQQAEAERAREEA 1631



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 61/290 (21%), Positives = 120/290 (41%), Gaps = 23/290 (7%)

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQK---KMQAKDREEQLAASECRRLQGKLSHEEAVL 113
            QVEQEL  +   ++         + +    K +A +   Q +  E      ++  EE   
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2246

Query: 114  ARQSLMQENKQRVEQQKEQMAKLMLQRAE--RRLREDRSRKELVEQ--------VIEGQK 163
             +  +  EN+  + + K+   + + + AE  +++ E+ +R  +  Q          E   
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2306

Query: 164  NAKAAQTKLAKGRQQTVQEA--IEESRGLLQRRAQAAQEEQRR---RCELISQLRALETQ 218
              +A   K+ K + Q VQEA  ++    LLQ++ + AQE+ RR     E ++Q  A ETQ
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366

Query: 219  PTRKGKLVDLTQIPGYGLEGE---MSIVELRERLALLKENQR--RKEEEKRDQIIQGKHT 273
              ++    +  +      E E   + + E+    A  +E+ +  RK+ E+  + +     
Sbjct: 2367 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2426

Query: 274  KSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLR 323
             +QE   +V+ + + R      A    E    L        Q+ ++ QL+
Sbjct: 2427 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 73/342 (21%), Positives = 139/342 (40%), Gaps = 61/342 (17%)

Query: 46   AILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR---- 101
            A   + A  + ++E EL R+    +      E    Q +++A  R+ QLAA E RR    
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKE----QAELEAA-RQRQLAAEEERRRREA 1990

Query: 102  ---LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQV 158
               +Q  L+ EE    ++    E  +R++ + E+  +L  +  +   R+ +  +E  ++ 
Sbjct: 1991 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2050

Query: 159  IEGQKNAKA-AQTKLAKGRQQTVQE---AIEESRGLLQRRAQAAQEEQRRRCELISQLRA 214
            ++ ++ A A A  +  +  QQT+Q+    +++ RG  +   +AA+E +  R +   +   
Sbjct: 2051 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2110

Query: 215  LETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTK 274
               Q                        VE  ERL        ++  E++ Q        
Sbjct: 2111 SRRQ------------------------VEEAERL--------KQSAEEQAQARAQAQAA 2138

Query: 275  SQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERS 334
            +++L+   EQ    R A    AALR ++        AA ++ E+ ++   +   + A+  
Sbjct: 2139 AEKLRKEAEQ-EAARRAQAEQAALRQKQ--------AADAEMEKHKKFAEQTLRQKAQVE 2189

Query: 335  RQAALLHVSAPRTARPKPRVSPDWWEEPGRLKAGAGWGWRAR 376
            ++   L +    T   K  +     EE  RLKA A    R R
Sbjct: 2190 QELTTLRLQLEETDHQKNLLD----EELQRLKAEATEAARQR 2227


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 83/341 (24%), Positives = 149/341 (43%), Gaps = 50/341 (14%)

Query: 6    RERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQR--------- 56
            ++R   + ++LRLQ     R+  +    R   + V L T     E  L  +         
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREE--------QLAASECRRLQGKLSH 108
            Q+E+ LQ     V    + +E    Q+    + REE        QL A+E  RL  +L  
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RLQA 1648

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
            EE V  ++SL Q   ++ +++ E+ A+   +  E+ +R+    +EL EQ +E Q+     
Sbjct: 1649 EE-VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ----RELAEQELEKQR----- 1698

Query: 169  QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC--ELISQLRALETQPTRKGKLV 226
              +LA+G   T Q+ +   + L++ RA+  Q EQ+R+   E +++L+      T+K +  
Sbjct: 1699 --QLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ-- 1751

Query: 227  DLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQIS 286
                      E E  + ++R  + +L  ++ R EEE R    + K     E     E   
Sbjct: 1752 ----------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801

Query: 287  LCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRIS 327
               AA  R+ A   + ++ LA   AA  + E  + L  +++
Sbjct: 1802 --EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 60/248 (24%), Positives = 113/248 (45%), Gaps = 28/248 (11%)

Query: 119  MQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQ 178
            + E  +R+E++ E++A+        RL E  +  E   Q+ E    AKA   + AK  QQ
Sbjct: 1337 ISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395

Query: 179  TVQEAI---EESRGLLQRRAQAAQEE---QRRRCELISQLRALETQPTRKGKL------- 225
             +QE +   EE+    Q++ ++ QEE    R+  E   Q +A + +   + +L       
Sbjct: 1396 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1455

Query: 226  -----VDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQN 280
                 ++ T+    G EGE+  +  R   A  ++ Q ++E E+  + +Q +  + ++   
Sbjct: 1456 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--- 1512

Query: 281  MVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
               ++ L       + A R E+++AL A      Q E  +   RR+ +   ER+RQ  + 
Sbjct: 1513 --AEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAE---RRLRQAEVERARQVQVA 1566

Query: 341  HVSAPRTA 348
              +A R+A
Sbjct: 1567 LETAQRSA 1574



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/350 (22%), Positives = 149/350 (42%), Gaps = 62/350 (17%)

Query: 45   TAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFE-----WQKKMQAKDREEQLAASEC 99
            T +  E  L Q+Q E   ++  +L +     ++        +Q+ ++A+ + +   ++E 
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382

Query: 100  RRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAK------------------LMLQRA 141
             RL+ +++      AR    +E+ QR  +Q E++ +                  L +QR 
Sbjct: 2383 ERLKLRVAEMSRAQARA---EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2439

Query: 142  E-----RRLRE-----DRSRKELVEQV----IEGQKNAKAAQTKLAKGRQQTVQEAIEES 187
            +      RLRE     +R +++L ++     ++ ++     Q +L +  Q   Q  + E 
Sbjct: 2440 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499

Query: 188  RGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRE 247
              LLQR  +   E+++ + E + Q    + Q  R+ +     Q+         S+ E R 
Sbjct: 2500 DSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557

Query: 248  RLALLKENQRRKEEEKR---DQIIQGKHTKSQELQNMVEQISLC----RAAMGRSAALRW 300
            R    +E  RRK+EE +    Q  Q +   ++E Q + EQ+ L     RAA+  S  +  
Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617

Query: 301  EEKKALAA---------APAAPSQDER-VQQLRRRISERAAERSRQAALL 340
             +  A             PAA ++ E     LRR++S   A+R ++A +L
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGIL 2664



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 78/327 (23%), Positives = 141/327 (43%), Gaps = 38/327 (11%)

Query: 48   LREGALYQRQVEQE---LQRVDK---LVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR 101
            L E A  QRQ+ +E    QR +    L +      E    + + +   +E++      RR
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1868

Query: 102  LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR--LRED--RSRKELVEQ 157
            L    + +   L  Q+   ++K  +E++  Q+ K      ER+  L ED  R R+++ E+
Sbjct: 1869 LAEDEAFQRRRLEEQAA--QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926

Query: 158  VIEGQKN-----AKAAQTKLAKGR-----QQTVQEAIEESRGLLQRRAQAAQEEQRRR-- 205
            ++  + +     A  A+ +L  GR     + T++   +      ++R  AA+EE+RRR  
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1986

Query: 206  CELISQLRALETQPT--RKGKLVDLTQIPGYGLEG----EMSIVELRERLALLKENQRRK 259
             E + +  A E +    RK  L ++ ++     E     E +  E   +L L +E  +++
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046

Query: 260  EEEKRDQIIQGKHTKSQELQNMVEQISLC------RAAMGRSAALRWEEKKALAAAPAAP 313
             + +          K QELQ  ++Q           A   R AA   EE +  A   AA 
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106

Query: 314  S--QDERVQQLRRRISERAAERSRQAA 338
            S  Q E  ++L++   E+A  R++  A
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQA 2133



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 59/261 (22%), Positives = 116/261 (44%), Gaps = 22/261 (8%)

Query: 86   QAKDREEQLAASECRRLQGKL-SHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR 144
            QAK + E+ A    +R+Q ++   EEA +  Q   +  ++ ++Q ++     +  +A + 
Sbjct: 1381 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440

Query: 145  LREDRSRKELVEQ--VIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ 202
               +RSR  + E+  V+  Q  A   Q   A+G  Q ++   EE+     ++ QA +E +
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAE 1497

Query: 203  RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEE 262
            R R ++       E+Q  R+ ++   +++     + E      ++R     E  R + EE
Sbjct: 1498 RLRRQVQD-----ESQRKRQAEVELASRV-----KAEAEAAREKQRALQALEELRLQAEE 1547

Query: 263  KRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQL 322
               ++ Q +  +++++Q  +E       A  +S    + EK A     +   +   V QL
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSLQEEHVAVAQL 1606

Query: 323  RRRISERA-----AERSRQAA 338
            R     RA     AER+R+ A
Sbjct: 1607 REEAERRAQQQAEAERAREEA 1627



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 61/290 (21%), Positives = 120/290 (41%), Gaps = 23/290 (7%)

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQK---KMQAKDREEQLAASECRRLQGKLSHEEAVL 113
            QVEQEL  +   ++         + +    K +A +   Q +  E      ++  EE   
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242

Query: 114  ARQSLMQENKQRVEQQKEQMAKLMLQRAE--RRLREDRSRKELVEQ--------VIEGQK 163
             +  +  EN+  + + K+   + + + AE  +++ E+ +R  +  Q          E   
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302

Query: 164  NAKAAQTKLAKGRQQTVQEA--IEESRGLLQRRAQAAQEEQRR---RCELISQLRALETQ 218
              +A   K+ K + Q VQEA  ++    LLQ++ + AQE+ RR     E ++Q  A ETQ
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362

Query: 219  PTRKGKLVDLTQIPGYGLEGE---MSIVELRERLALLKENQR--RKEEEKRDQIIQGKHT 273
              ++    +  +      E E   + + E+    A  +E+ +  RK+ E+  + +     
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2422

Query: 274  KSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLR 323
             +QE   +V+ + + R      A    E    L        Q+ ++ QL+
Sbjct: 2423 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 73/342 (21%), Positives = 139/342 (40%), Gaps = 61/342 (17%)

Query: 46   AILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR---- 101
            A   + A  + ++E EL R+    +      E    Q +++A  R+ QLAA E RR    
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKE----QAELEAA-RQRQLAAEEERRRREA 1986

Query: 102  ---LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQV 158
               +Q  L+ EE    ++    E  +R++ + E+  +L  +  +   R+ +  +E  ++ 
Sbjct: 1987 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2046

Query: 159  IEGQKNAKA-AQTKLAKGRQQTVQE---AIEESRGLLQRRAQAAQEEQRRRCELISQLRA 214
            ++ ++ A A A  +  +  QQT+Q+    +++ RG  +   +AA+E +  R +   +   
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106

Query: 215  LETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTK 274
               Q                        VE  ERL        ++  E++ Q        
Sbjct: 2107 SRRQ------------------------VEEAERL--------KQSAEEQAQARAQAQAA 2134

Query: 275  SQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERS 334
            +++L+   EQ    R A    AALR ++        AA ++ E+ ++   +   + A+  
Sbjct: 2135 AEKLRKEAEQ-EAARRAQAEQAALRQKQ--------AADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 335  RQAALLHVSAPRTARPKPRVSPDWWEEPGRLKAGAGWGWRAR 376
            ++   L +    T   K  +     EE  RLKA A    R R
Sbjct: 2186 QELTTLRLQLEETDHQKNLLD----EELQRLKAEATEAARQR 2223


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 83/341 (24%), Positives = 149/341 (43%), Gaps = 50/341 (14%)

Query: 6    RERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQR--------- 56
            ++R   + ++LRLQ     R+  +    R   + V L T     E  L  +         
Sbjct: 1499 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1558

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREE--------QLAASECRRLQGKLSH 108
            Q+E+ LQ     V    + +E    Q+    + REE        QL A+E  RL  +L  
Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RLQA 1616

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
            EE V  ++SL Q   ++ +++ E+ A+   +  E+ +R+    +EL EQ +E Q+     
Sbjct: 1617 EE-VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ----RELAEQELEKQR----- 1666

Query: 169  QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC--ELISQLRALETQPTRKGKLV 226
              +LA+G   T Q+ +   + L++ RA+  Q EQ+R+   E +++L+      T+K +  
Sbjct: 1667 --QLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ-- 1719

Query: 227  DLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQIS 286
                      E E  + ++R  + +L  ++ R EEE R    + K     E     E   
Sbjct: 1720 ----------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769

Query: 287  LCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRIS 327
               AA  R+ A   + ++ LA   AA  + E  + L  +++
Sbjct: 1770 --EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 60/248 (24%), Positives = 113/248 (45%), Gaps = 28/248 (11%)

Query: 119  MQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQ 178
            + E  +R+E++ E++A+        RL E  +  E   Q+ E    AKA   + AK  QQ
Sbjct: 1305 ISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1363

Query: 179  TVQEAI---EESRGLLQRRAQAAQEE---QRRRCELISQLRALETQPTRKGKL------- 225
             +QE +   EE+    Q++ ++ QEE    R+  E   Q +A + +   + +L       
Sbjct: 1364 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1423

Query: 226  -----VDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQN 280
                 ++ T+    G EGE+  +  R   A  ++ Q ++E E+  + +Q +  + ++   
Sbjct: 1424 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--- 1480

Query: 281  MVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
               ++ L       + A R E+++AL A      Q E  +   RR+ +   ER+RQ  + 
Sbjct: 1481 --AEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAE---RRLRQAEVERARQVQVA 1534

Query: 341  HVSAPRTA 348
              +A R+A
Sbjct: 1535 LETAQRSA 1542



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/350 (22%), Positives = 149/350 (42%), Gaps = 62/350 (17%)

Query: 45   TAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFE-----WQKKMQAKDREEQLAASEC 99
            T +  E  L Q+Q E   ++  +L +     ++        +Q+ ++A+ + +   ++E 
Sbjct: 2291 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2350

Query: 100  RRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAK------------------LMLQRA 141
             RL+ +++      AR    +E+ QR  +Q E++ +                  L +QR 
Sbjct: 2351 ERLKLRVAEMSRAQARA---EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2407

Query: 142  E-----RRLRE-----DRSRKELVEQV----IEGQKNAKAAQTKLAKGRQQTVQEAIEES 187
            +      RLRE     +R +++L ++     ++ ++     Q +L +  Q   Q  + E 
Sbjct: 2408 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2467

Query: 188  RGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRE 247
              LLQR  +   E+++ + E + Q    + Q  R+ +     Q+         S+ E R 
Sbjct: 2468 DSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525

Query: 248  RLALLKENQRRKEEEKR---DQIIQGKHTKSQELQNMVEQISLC----RAAMGRSAALRW 300
            R    +E  RRK+EE +    Q  Q +   ++E Q + EQ+ L     RAA+  S  +  
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585

Query: 301  EEKKALAA---------APAAPSQDER-VQQLRRRISERAAERSRQAALL 340
             +  A             PAA ++ E     LRR++S   A+R ++A +L
Sbjct: 2586 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGIL 2632



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 78/327 (23%), Positives = 141/327 (43%), Gaps = 38/327 (11%)

Query: 48   LREGALYQRQVEQE---LQRVDK---LVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR 101
            L E A  QRQ+ +E    QR +    L +      E    + + +   +E++      RR
Sbjct: 1777 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1836

Query: 102  LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR--LRED--RSRKELVEQ 157
            L    + +   L  Q+   ++K  +E++  Q+ K      ER+  L ED  R R+++ E+
Sbjct: 1837 LAEDEAFQRRRLEEQAA--QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894

Query: 158  VIEGQKN-----AKAAQTKLAKGR-----QQTVQEAIEESRGLLQRRAQAAQEEQRRR-- 205
            ++  + +     A  A+ +L  GR     + T++   +      ++R  AA+EE+RRR  
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1954

Query: 206  CELISQLRALETQPT--RKGKLVDLTQIPGYGLEG----EMSIVELRERLALLKENQRRK 259
             E + +  A E +    RK  L ++ ++     E     E +  E   +L L +E  +++
Sbjct: 1955 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2014

Query: 260  EEEKRDQIIQGKHTKSQELQNMVEQISLC------RAAMGRSAALRWEEKKALAAAPAAP 313
             + +          K QELQ  ++Q           A   R AA   EE +  A   AA 
Sbjct: 2015 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2074

Query: 314  S--QDERVQQLRRRISERAAERSRQAA 338
            S  Q E  ++L++   E+A  R++  A
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQA 2101



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 59/261 (22%), Positives = 116/261 (44%), Gaps = 22/261 (8%)

Query: 86   QAKDREEQLAASECRRLQGKL-SHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR 144
            QAK + E+ A    +R+Q ++   EEA +  Q   +  ++ ++Q ++     +  +A + 
Sbjct: 1349 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1408

Query: 145  LREDRSRKELVEQ--VIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ 202
               +RSR  + E+  V+  Q  A   Q   A+G  Q ++   EE+     ++ QA +E +
Sbjct: 1409 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAE 1465

Query: 203  RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEE 262
            R R ++       E+Q  R+ ++   +++     + E      ++R     E  R + EE
Sbjct: 1466 RLRRQVQD-----ESQRKRQAEVELASRV-----KAEAEAAREKQRALQALEELRLQAEE 1515

Query: 263  KRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQL 322
               ++ Q +  +++++Q  +E       A  +S    + EK A     +   +   V QL
Sbjct: 1516 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSLQEEHVAVAQL 1574

Query: 323  RRRISERA-----AERSRQAA 338
            R     RA     AER+R+ A
Sbjct: 1575 REEAERRAQQQAEAERAREEA 1595



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 61/290 (21%), Positives = 120/290 (41%), Gaps = 23/290 (7%)

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQK---KMQAKDREEQLAASECRRLQGKLSHEEAVL 113
            QVEQEL  +   ++         + +    K +A +   Q +  E      ++  EE   
Sbjct: 2151 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2210

Query: 114  ARQSLMQENKQRVEQQKEQMAKLMLQRAE--RRLREDRSRKELVEQ--------VIEGQK 163
             +  +  EN+  + + K+   + + + AE  +++ E+ +R  +  Q          E   
Sbjct: 2211 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2270

Query: 164  NAKAAQTKLAKGRQQTVQEA--IEESRGLLQRRAQAAQEEQRR---RCELISQLRALETQ 218
              +A   K+ K + Q VQEA  ++    LLQ++ + AQE+ RR     E ++Q  A ETQ
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330

Query: 219  PTRKGKLVDLTQIPGYGLEGE---MSIVELRERLALLKENQR--RKEEEKRDQIIQGKHT 273
              ++    +  +      E E   + + E+    A  +E+ +  RK+ E+  + +     
Sbjct: 2331 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2390

Query: 274  KSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLR 323
             +QE   +V+ + + R      A    E    L        Q+ ++ QL+
Sbjct: 2391 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 73/342 (21%), Positives = 139/342 (40%), Gaps = 61/342 (17%)

Query: 46   AILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR---- 101
            A   + A  + ++E EL R+    +      E    Q +++A  R+ QLAA E RR    
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKE----QAELEAA-RQRQLAAEEERRRREA 1954

Query: 102  ---LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQV 158
               +Q  L+ EE    ++    E  +R++ + E+  +L  +  +   R+ +  +E  ++ 
Sbjct: 1955 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2014

Query: 159  IEGQKNAKA-AQTKLAKGRQQTVQE---AIEESRGLLQRRAQAAQEEQRRRCELISQLRA 214
            ++ ++ A A A  +  +  QQT+Q+    +++ RG  +   +AA+E +  R +   +   
Sbjct: 2015 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2074

Query: 215  LETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTK 274
               Q                        VE  ERL        ++  E++ Q        
Sbjct: 2075 SRRQ------------------------VEEAERL--------KQSAEEQAQARAQAQAA 2102

Query: 275  SQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERS 334
            +++L+   EQ    R A    AALR ++        AA ++ E+ ++   +   + A+  
Sbjct: 2103 AEKLRKEAEQ-EAARRAQAEQAALRQKQ--------AADAEMEKHKKFAEQTLRQKAQVE 2153

Query: 335  RQAALLHVSAPRTARPKPRVSPDWWEEPGRLKAGAGWGWRAR 376
            ++   L +    T   K  +     EE  RLKA A    R R
Sbjct: 2154 QELTTLRLQLEETDHQKNLLD----EELQRLKAEATEAARQR 2191


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 83/341 (24%), Positives = 149/341 (43%), Gaps = 50/341 (14%)

Query: 6    RERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQR--------- 56
            ++R   + ++LRLQ     R+  +    R   + V L T     E  L  +         
Sbjct: 1668 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1727

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREE--------QLAASECRRLQGKLSH 108
            Q+E+ LQ     V    + +E    Q+    + REE        QL A+E  RL  +L  
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RLQA 1785

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
            EE V  ++SL Q   ++ +++ E+ A+   +  E+ +R+    +EL EQ +E Q+     
Sbjct: 1786 EE-VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ----RELAEQELEKQR----- 1835

Query: 169  QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC--ELISQLRALETQPTRKGKLV 226
              +LA+G   T Q+ +   + L++ RA+  Q EQ+R+   E +++L+      T+K +  
Sbjct: 1836 --QLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ-- 1888

Query: 227  DLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQIS 286
                      E E  + ++R  + +L  ++ R EEE R    + K     E     E   
Sbjct: 1889 ----------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938

Query: 287  LCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRIS 327
               AA  R+ A   + ++ LA   AA  + E  + L  +++
Sbjct: 1939 --EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 60/248 (24%), Positives = 113/248 (45%), Gaps = 28/248 (11%)

Query: 119  MQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQ 178
            + E  +R+E++ E++A+        RL E  +  E   Q+ E    AKA   + AK  QQ
Sbjct: 1474 ISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1532

Query: 179  TVQEAI---EESRGLLQRRAQAAQEE---QRRRCELISQLRALETQPTRKGKL------- 225
             +QE +   EE+    Q++ ++ QEE    R+  E   Q +A + +   + +L       
Sbjct: 1533 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1592

Query: 226  -----VDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQN 280
                 ++ T+    G EGE+  +  R   A  ++ Q ++E E+  + +Q +  + ++   
Sbjct: 1593 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--- 1649

Query: 281  MVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
               ++ L       + A R E+++AL A      Q E  +   RR+ +   ER+RQ  + 
Sbjct: 1650 --AEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAE---RRLRQAEVERARQVQVA 1703

Query: 341  HVSAPRTA 348
              +A R+A
Sbjct: 1704 LETAQRSA 1711



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/350 (22%), Positives = 149/350 (42%), Gaps = 62/350 (17%)

Query: 45   TAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFE-----WQKKMQAKDREEQLAASEC 99
            T +  E  L Q+Q E   ++  +L +     ++        +Q+ ++A+ + +   ++E 
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519

Query: 100  RRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAK------------------LMLQRA 141
             RL+ +++      AR    +E+ QR  +Q E++ +                  L +QR 
Sbjct: 2520 ERLKLRVAEMSRAQARA---EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2576

Query: 142  E-----RRLRE-----DRSRKELVEQV----IEGQKNAKAAQTKLAKGRQQTVQEAIEES 187
            +      RLRE     +R +++L ++     ++ ++     Q +L +  Q   Q  + E 
Sbjct: 2577 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2636

Query: 188  RGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRE 247
              LLQR  +   E+++ + E + Q    + Q  R+ +     Q+         S+ E R 
Sbjct: 2637 DSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694

Query: 248  RLALLKENQRRKEEEKR---DQIIQGKHTKSQELQNMVEQISLC----RAAMGRSAALRW 300
            R    +E  RRK+EE +    Q  Q +   ++E Q + EQ+ L     RAA+  S  +  
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754

Query: 301  EEKKALAA---------APAAPSQDER-VQQLRRRISERAAERSRQAALL 340
             +  A             PAA ++ E     LRR++S   A+R ++A +L
Sbjct: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGIL 2801



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 78/327 (23%), Positives = 141/327 (43%), Gaps = 38/327 (11%)

Query: 48   LREGALYQRQVEQE---LQRVDK---LVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR 101
            L E A  QRQ+ +E    QR +    L +      E    + + +   +E++      RR
Sbjct: 1946 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 2005

Query: 102  LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR--LRED--RSRKELVEQ 157
            L    + +   L  Q+   ++K  +E++  Q+ K      ER+  L ED  R R+++ E+
Sbjct: 2006 LAEDEAFQRRRLEEQAA--QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063

Query: 158  VIEGQKN-----AKAAQTKLAKGR-----QQTVQEAIEESRGLLQRRAQAAQEEQRRR-- 205
            ++  + +     A  A+ +L  GR     + T++   +      ++R  AA+EE+RRR  
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2123

Query: 206  CELISQLRALETQPT--RKGKLVDLTQIPGYGLEG----EMSIVELRERLALLKENQRRK 259
             E + +  A E +    RK  L ++ ++     E     E +  E   +L L +E  +++
Sbjct: 2124 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2183

Query: 260  EEEKRDQIIQGKHTKSQELQNMVEQISLC------RAAMGRSAALRWEEKKALAAAPAAP 313
             + +          K QELQ  ++Q           A   R AA   EE +  A   AA 
Sbjct: 2184 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2243

Query: 314  S--QDERVQQLRRRISERAAERSRQAA 338
            S  Q E  ++L++   E+A  R++  A
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQA 2270



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 59/261 (22%), Positives = 116/261 (44%), Gaps = 22/261 (8%)

Query: 86   QAKDREEQLAASECRRLQGKL-SHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR 144
            QAK + E+ A    +R+Q ++   EEA +  Q   +  ++ ++Q ++     +  +A + 
Sbjct: 1518 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1577

Query: 145  LREDRSRKELVEQ--VIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ 202
               +RSR  + E+  V+  Q  A   Q   A+G  Q ++   EE+     ++ QA +E +
Sbjct: 1578 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAE 1634

Query: 203  RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEE 262
            R R ++       E+Q  R+ ++   +++     + E      ++R     E  R + EE
Sbjct: 1635 RLRRQVQD-----ESQRKRQAEVELASRV-----KAEAEAAREKQRALQALEELRLQAEE 1684

Query: 263  KRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQL 322
               ++ Q +  +++++Q  +E       A  +S    + EK A     +   +   V QL
Sbjct: 1685 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSLQEEHVAVAQL 1743

Query: 323  RRRISERA-----AERSRQAA 338
            R     RA     AER+R+ A
Sbjct: 1744 REEAERRAQQQAEAERAREEA 1764



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 61/290 (21%), Positives = 120/290 (41%), Gaps = 23/290 (7%)

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQK---KMQAKDREEQLAASECRRLQGKLSHEEAVL 113
            QVEQEL  +   ++         + +    K +A +   Q +  E      ++  EE   
Sbjct: 2320 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2379

Query: 114  ARQSLMQENKQRVEQQKEQMAKLMLQRAE--RRLREDRSRKELVEQ--------VIEGQK 163
             +  +  EN+  + + K+   + + + AE  +++ E+ +R  +  Q          E   
Sbjct: 2380 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2439

Query: 164  NAKAAQTKLAKGRQQTVQEA--IEESRGLLQRRAQAAQEEQRR---RCELISQLRALETQ 218
              +A   K+ K + Q VQEA  ++    LLQ++ + AQE+ RR     E ++Q  A ETQ
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499

Query: 219  PTRKGKLVDLTQIPGYGLEGE---MSIVELRERLALLKENQR--RKEEEKRDQIIQGKHT 273
              ++    +  +      E E   + + E+    A  +E+ +  RK+ E+  + +     
Sbjct: 2500 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2559

Query: 274  KSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLR 323
             +QE   +V+ + + R      A    E    L        Q+ ++ QL+
Sbjct: 2560 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 73/342 (21%), Positives = 139/342 (40%), Gaps = 61/342 (17%)

Query: 46   AILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR---- 101
            A   + A  + ++E EL R+    +      E    Q +++A  R+ QLAA E RR    
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRSKE----QAELEAA-RQRQLAAEEERRRREA 2123

Query: 102  ---LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQV 158
               +Q  L+ EE    ++    E  +R++ + E+  +L  +  +   R+ +  +E  ++ 
Sbjct: 2124 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2183

Query: 159  IEGQKNAKA-AQTKLAKGRQQTVQE---AIEESRGLLQRRAQAAQEEQRRRCELISQLRA 214
            ++ ++ A A A  +  +  QQT+Q+    +++ RG  +   +AA+E +  R +   +   
Sbjct: 2184 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2243

Query: 215  LETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTK 274
               Q                        VE  ERL        ++  E++ Q        
Sbjct: 2244 SRRQ------------------------VEEAERL--------KQSAEEQAQARAQAQAA 2271

Query: 275  SQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERS 334
            +++L+   EQ    R A    AALR ++        AA ++ E+ ++   +   + A+  
Sbjct: 2272 AEKLRKEAEQ-EAARRAQAEQAALRQKQ--------AADAEMEKHKKFAEQTLRQKAQVE 2322

Query: 335  RQAALLHVSAPRTARPKPRVSPDWWEEPGRLKAGAGWGWRAR 376
            ++   L +    T   K  +     EE  RLKA A    R R
Sbjct: 2323 QELTTLRLQLEETDHQKNLLD----EELQRLKAEATEAARQR 2360


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 83/341 (24%), Positives = 149/341 (43%), Gaps = 50/341 (14%)

Query: 6    RERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQR--------- 56
            ++R   + ++LRLQ     R+  +    R   + V L T     E  L  +         
Sbjct: 1509 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1568

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREE--------QLAASECRRLQGKLSH 108
            Q+E+ LQ     V    + +E    Q+    + REE        QL A+E  RL  +L  
Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RLQA 1626

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
            EE V  ++SL Q   ++ +++ E+ A+   +  E+ +R+    +EL EQ +E Q+     
Sbjct: 1627 EE-VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ----RELAEQELEKQR----- 1676

Query: 169  QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC--ELISQLRALETQPTRKGKLV 226
              +LA+G   T Q+ +   + L++ RA+  Q EQ+R+   E +++L+      T+K +  
Sbjct: 1677 --QLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ-- 1729

Query: 227  DLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQIS 286
                      E E  + ++R  + +L  ++ R EEE R    + K     E     E   
Sbjct: 1730 ----------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779

Query: 287  LCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRIS 327
               AA  R+ A   + ++ LA   AA  + E  + L  +++
Sbjct: 1780 --EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 60/248 (24%), Positives = 113/248 (45%), Gaps = 28/248 (11%)

Query: 119  MQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQ 178
            + E  +R+E++ E++A+        RL E  +  E   Q+ E    AKA   + AK  QQ
Sbjct: 1315 ISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1373

Query: 179  TVQEAI---EESRGLLQRRAQAAQEE---QRRRCELISQLRALETQPTRKGKL------- 225
             +QE +   EE+    Q++ ++ QEE    R+  E   Q +A + +   + +L       
Sbjct: 1374 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1433

Query: 226  -----VDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQN 280
                 ++ T+    G EGE+  +  R   A  ++ Q ++E E+  + +Q +  + ++   
Sbjct: 1434 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--- 1490

Query: 281  MVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
               ++ L       + A R E+++AL A      Q E  +   RR+ +   ER+RQ  + 
Sbjct: 1491 --AEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAE---RRLRQAEVERARQVQVA 1544

Query: 341  HVSAPRTA 348
              +A R+A
Sbjct: 1545 LETAQRSA 1552



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/350 (22%), Positives = 149/350 (42%), Gaps = 62/350 (17%)

Query: 45   TAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFE-----WQKKMQAKDREEQLAASEC 99
            T +  E  L Q+Q E   ++  +L +     ++        +Q+ ++A+ + +   ++E 
Sbjct: 2301 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360

Query: 100  RRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAK------------------LMLQRA 141
             RL+ +++      AR    +E+ QR  +Q E++ +                  L +QR 
Sbjct: 2361 ERLKLRVAEMSRAQARA---EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2417

Query: 142  E-----RRLRE-----DRSRKELVEQV----IEGQKNAKAAQTKLAKGRQQTVQEAIEES 187
            +      RLRE     +R +++L ++     ++ ++     Q +L +  Q   Q  + E 
Sbjct: 2418 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2477

Query: 188  RGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRE 247
              LLQR  +   E+++ + E + Q    + Q  R+ +     Q+         S+ E R 
Sbjct: 2478 DSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535

Query: 248  RLALLKENQRRKEEEKR---DQIIQGKHTKSQELQNMVEQISLC----RAAMGRSAALRW 300
            R    +E  RRK+EE +    Q  Q +   ++E Q + EQ+ L     RAA+  S  +  
Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595

Query: 301  EEKKALAA---------APAAPSQDER-VQQLRRRISERAAERSRQAALL 340
             +  A             PAA ++ E     LRR++S   A+R ++A +L
Sbjct: 2596 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGIL 2642



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 78/327 (23%), Positives = 141/327 (43%), Gaps = 38/327 (11%)

Query: 48   LREGALYQRQVEQE---LQRVDK---LVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR 101
            L E A  QRQ+ +E    QR +    L +      E    + + +   +E++      RR
Sbjct: 1787 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1846

Query: 102  LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR--LRED--RSRKELVEQ 157
            L    + +   L  Q+   ++K  +E++  Q+ K      ER+  L ED  R R+++ E+
Sbjct: 1847 LAEDEAFQRRRLEEQAA--QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904

Query: 158  VIEGQKN-----AKAAQTKLAKGR-----QQTVQEAIEESRGLLQRRAQAAQEEQRRR-- 205
            ++  + +     A  A+ +L  GR     + T++   +      ++R  AA+EE+RRR  
Sbjct: 1905 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1964

Query: 206  CELISQLRALETQPT--RKGKLVDLTQIPGYGLEG----EMSIVELRERLALLKENQRRK 259
             E + +  A E +    RK  L ++ ++     E     E +  E   +L L +E  +++
Sbjct: 1965 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2024

Query: 260  EEEKRDQIIQGKHTKSQELQNMVEQISLC------RAAMGRSAALRWEEKKALAAAPAAP 313
             + +          K QELQ  ++Q           A   R AA   EE +  A   AA 
Sbjct: 2025 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2084

Query: 314  S--QDERVQQLRRRISERAAERSRQAA 338
            S  Q E  ++L++   E+A  R++  A
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQA 2111



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 59/261 (22%), Positives = 116/261 (44%), Gaps = 22/261 (8%)

Query: 86   QAKDREEQLAASECRRLQGKL-SHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR 144
            QAK + E+ A    +R+Q ++   EEA +  Q   +  ++ ++Q ++     +  +A + 
Sbjct: 1359 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1418

Query: 145  LREDRSRKELVEQ--VIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ 202
               +RSR  + E+  V+  Q  A   Q   A+G  Q ++   EE+     ++ QA +E +
Sbjct: 1419 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAE 1475

Query: 203  RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEE 262
            R R ++       E+Q  R+ ++   +++     + E      ++R     E  R + EE
Sbjct: 1476 RLRRQVQD-----ESQRKRQAEVELASRV-----KAEAEAAREKQRALQALEELRLQAEE 1525

Query: 263  KRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQL 322
               ++ Q +  +++++Q  +E       A  +S    + EK A     +   +   V QL
Sbjct: 1526 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSLQEEHVAVAQL 1584

Query: 323  RRRISERA-----AERSRQAA 338
            R     RA     AER+R+ A
Sbjct: 1585 REEAERRAQQQAEAERAREEA 1605



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 61/290 (21%), Positives = 120/290 (41%), Gaps = 23/290 (7%)

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQK---KMQAKDREEQLAASECRRLQGKLSHEEAVL 113
            QVEQEL  +   ++         + +    K +A +   Q +  E      ++  EE   
Sbjct: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220

Query: 114  ARQSLMQENKQRVEQQKEQMAKLMLQRAE--RRLREDRSRKELVEQ--------VIEGQK 163
             +  +  EN+  + + K+   + + + AE  +++ E+ +R  +  Q          E   
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280

Query: 164  NAKAAQTKLAKGRQQTVQEA--IEESRGLLQRRAQAAQEEQRR---RCELISQLRALETQ 218
              +A   K+ K + Q VQEA  ++    LLQ++ + AQE+ RR     E ++Q  A ETQ
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340

Query: 219  PTRKGKLVDLTQIPGYGLEGE---MSIVELRERLALLKENQR--RKEEEKRDQIIQGKHT 273
              ++    +  +      E E   + + E+    A  +E+ +  RK+ E+  + +     
Sbjct: 2341 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2400

Query: 274  KSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLR 323
             +QE   +V+ + + R      A    E    L        Q+ ++ QL+
Sbjct: 2401 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2450



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 73/342 (21%), Positives = 139/342 (40%), Gaps = 61/342 (17%)

Query: 46   AILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR---- 101
            A   + A  + ++E EL R+    +      E    Q +++A  R+ QLAA E RR    
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRSKE----QAELEAA-RQRQLAAEEERRRREA 1964

Query: 102  ---LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQV 158
               +Q  L+ EE    ++    E  +R++ + E+  +L  +  +   R+ +  +E  ++ 
Sbjct: 1965 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2024

Query: 159  IEGQKNAKA-AQTKLAKGRQQTVQE---AIEESRGLLQRRAQAAQEEQRRRCELISQLRA 214
            ++ ++ A A A  +  +  QQT+Q+    +++ RG  +   +AA+E +  R +   +   
Sbjct: 2025 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2084

Query: 215  LETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTK 274
               Q                        VE  ERL        ++  E++ Q        
Sbjct: 2085 SRRQ------------------------VEEAERL--------KQSAEEQAQARAQAQAA 2112

Query: 275  SQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERS 334
            +++L+   EQ    R A    AALR ++        AA ++ E+ ++   +   + A+  
Sbjct: 2113 AEKLRKEAEQ-EAARRAQAEQAALRQKQ--------AADAEMEKHKKFAEQTLRQKAQVE 2163

Query: 335  RQAALLHVSAPRTARPKPRVSPDWWEEPGRLKAGAGWGWRAR 376
            ++   L +    T   K  +     EE  RLKA A    R R
Sbjct: 2164 QELTTLRLQLEETDHQKNLLD----EELQRLKAEATEAARQR 2201


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 83/341 (24%), Positives = 149/341 (43%), Gaps = 50/341 (14%)

Query: 6    RERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQR--------- 56
            ++R   + ++LRLQ     R+  +    R   + V L T     E  L  +         
Sbjct: 1517 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1576

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREE--------QLAASECRRLQGKLSH 108
            Q+E+ LQ     V    + +E    Q+    + REE        QL A+E  RL  +L  
Sbjct: 1577 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RLQA 1634

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
            EE V  ++SL Q   ++ +++ E+ A+   +  E+ +R+    +EL EQ +E Q+     
Sbjct: 1635 EE-VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ----RELAEQELEKQR----- 1684

Query: 169  QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC--ELISQLRALETQPTRKGKLV 226
              +LA+G   T Q+ +   + L++ RA+  Q EQ+R+   E +++L+      T+K +  
Sbjct: 1685 --QLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ-- 1737

Query: 227  DLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQIS 286
                      E E  + ++R  + +L  ++ R EEE R    + K     E     E   
Sbjct: 1738 ----------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787

Query: 287  LCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRIS 327
               AA  R+ A   + ++ LA   AA  + E  + L  +++
Sbjct: 1788 --EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 60/248 (24%), Positives = 113/248 (45%), Gaps = 28/248 (11%)

Query: 119  MQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQ 178
            + E  +R+E++ E++A+        RL E  +  E   Q+ E    AKA   + AK  QQ
Sbjct: 1323 ISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1381

Query: 179  TVQEAI---EESRGLLQRRAQAAQEE---QRRRCELISQLRALETQPTRKGKL------- 225
             +QE +   EE+    Q++ ++ QEE    R+  E   Q +A + +   + +L       
Sbjct: 1382 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1441

Query: 226  -----VDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQN 280
                 ++ T+    G EGE+  +  R   A  ++ Q ++E E+  + +Q +  + ++   
Sbjct: 1442 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--- 1498

Query: 281  MVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
               ++ L       + A R E+++AL A      Q E  +   RR+ +   ER+RQ  + 
Sbjct: 1499 --AEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAE---RRLRQAEVERARQVQVA 1552

Query: 341  HVSAPRTA 348
              +A R+A
Sbjct: 1553 LETAQRSA 1560



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/350 (22%), Positives = 149/350 (42%), Gaps = 62/350 (17%)

Query: 45   TAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFE-----WQKKMQAKDREEQLAASEC 99
            T +  E  L Q+Q E   ++  +L +     ++        +Q+ ++A+ + +   ++E 
Sbjct: 2309 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2368

Query: 100  RRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAK------------------LMLQRA 141
             RL+ +++      AR    +E+ QR  +Q E++ +                  L +QR 
Sbjct: 2369 ERLKLRVAEMSRAQARA---EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2425

Query: 142  E-----RRLRE-----DRSRKELVEQV----IEGQKNAKAAQTKLAKGRQQTVQEAIEES 187
            +      RLRE     +R +++L ++     ++ ++     Q +L +  Q   Q  + E 
Sbjct: 2426 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2485

Query: 188  RGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRE 247
              LLQR  +   E+++ + E + Q    + Q  R+ +     Q+         S+ E R 
Sbjct: 2486 DSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543

Query: 248  RLALLKENQRRKEEEKR---DQIIQGKHTKSQELQNMVEQISLC----RAAMGRSAALRW 300
            R    +E  RRK+EE +    Q  Q +   ++E Q + EQ+ L     RAA+  S  +  
Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2603

Query: 301  EEKKALAA---------APAAPSQDER-VQQLRRRISERAAERSRQAALL 340
             +  A             PAA ++ E     LRR++S   A+R ++A +L
Sbjct: 2604 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGIL 2650



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 78/327 (23%), Positives = 141/327 (43%), Gaps = 38/327 (11%)

Query: 48   LREGALYQRQVEQE---LQRVDK---LVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR 101
            L E A  QRQ+ +E    QR +    L +      E    + + +   +E++      RR
Sbjct: 1795 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1854

Query: 102  LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR--LRED--RSRKELVEQ 157
            L    + +   L  Q+   ++K  +E++  Q+ K      ER+  L ED  R R+++ E+
Sbjct: 1855 LAEDEAFQRRRLEEQAA--QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912

Query: 158  VIEGQKN-----AKAAQTKLAKGR-----QQTVQEAIEESRGLLQRRAQAAQEEQRRR-- 205
            ++  + +     A  A+ +L  GR     + T++   +      ++R  AA+EE+RRR  
Sbjct: 1913 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 1972

Query: 206  CELISQLRALETQPT--RKGKLVDLTQIPGYGLEG----EMSIVELRERLALLKENQRRK 259
             E + +  A E +    RK  L ++ ++     E     E +  E   +L L +E  +++
Sbjct: 1973 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2032

Query: 260  EEEKRDQIIQGKHTKSQELQNMVEQISLC------RAAMGRSAALRWEEKKALAAAPAAP 313
             + +          K QELQ  ++Q           A   R AA   EE +  A   AA 
Sbjct: 2033 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2092

Query: 314  S--QDERVQQLRRRISERAAERSRQAA 338
            S  Q E  ++L++   E+A  R++  A
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQA 2119



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 59/261 (22%), Positives = 116/261 (44%), Gaps = 22/261 (8%)

Query: 86   QAKDREEQLAASECRRLQGKL-SHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR 144
            QAK + E+ A    +R+Q ++   EEA +  Q   +  ++ ++Q ++     +  +A + 
Sbjct: 1367 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1426

Query: 145  LREDRSRKELVEQ--VIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ 202
               +RSR  + E+  V+  Q  A   Q   A+G  Q ++   EE+     ++ QA +E +
Sbjct: 1427 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAE 1483

Query: 203  RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEE 262
            R R ++       E+Q  R+ ++   +++     + E      ++R     E  R + EE
Sbjct: 1484 RLRRQVQD-----ESQRKRQAEVELASRV-----KAEAEAAREKQRALQALEELRLQAEE 1533

Query: 263  KRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQL 322
               ++ Q +  +++++Q  +E       A  +S    + EK A     +   +   V QL
Sbjct: 1534 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSLQEEHVAVAQL 1592

Query: 323  RRRISERA-----AERSRQAA 338
            R     RA     AER+R+ A
Sbjct: 1593 REEAERRAQQQAEAERAREEA 1613



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 61/290 (21%), Positives = 120/290 (41%), Gaps = 23/290 (7%)

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQK---KMQAKDREEQLAASECRRLQGKLSHEEAVL 113
            QVEQEL  +   ++         + +    K +A +   Q +  E      ++  EE   
Sbjct: 2169 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2228

Query: 114  ARQSLMQENKQRVEQQKEQMAKLMLQRAE--RRLREDRSRKELVEQ--------VIEGQK 163
             +  +  EN+  + + K+   + + + AE  +++ E+ +R  +  Q          E   
Sbjct: 2229 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2288

Query: 164  NAKAAQTKLAKGRQQTVQEA--IEESRGLLQRRAQAAQEEQRR---RCELISQLRALETQ 218
              +A   K+ K + Q VQEA  ++    LLQ++ + AQE+ RR     E ++Q  A ETQ
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348

Query: 219  PTRKGKLVDLTQIPGYGLEGE---MSIVELRERLALLKENQR--RKEEEKRDQIIQGKHT 273
              ++    +  +      E E   + + E+    A  +E+ +  RK+ E+  + +     
Sbjct: 2349 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2408

Query: 274  KSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLR 323
             +QE   +V+ + + R      A    E    L        Q+ ++ QL+
Sbjct: 2409 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2458



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 73/342 (21%), Positives = 139/342 (40%), Gaps = 61/342 (17%)

Query: 46   AILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR---- 101
            A   + A  + ++E EL R+    +      E    Q +++A  R+ QLAA E RR    
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLRSKE----QAELEAA-RQRQLAAEEERRRREA 1972

Query: 102  ---LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQV 158
               +Q  L+ EE    ++    E  +R++ + E+  +L  +  +   R+ +  +E  ++ 
Sbjct: 1973 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2032

Query: 159  IEGQKNAKA-AQTKLAKGRQQTVQE---AIEESRGLLQRRAQAAQEEQRRRCELISQLRA 214
            ++ ++ A A A  +  +  QQT+Q+    +++ RG  +   +AA+E +  R +   +   
Sbjct: 2033 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2092

Query: 215  LETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTK 274
               Q                        VE  ERL        ++  E++ Q        
Sbjct: 2093 SRRQ------------------------VEEAERL--------KQSAEEQAQARAQAQAA 2120

Query: 275  SQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERS 334
            +++L+   EQ    R A    AALR ++        AA ++ E+ ++   +   + A+  
Sbjct: 2121 AEKLRKEAEQ-EAARRAQAEQAALRQKQ--------AADAEMEKHKKFAEQTLRQKAQVE 2171

Query: 335  RQAALLHVSAPRTARPKPRVSPDWWEEPGRLKAGAGWGWRAR 376
            ++   L +    T   K  +     EE  RLKA A    R R
Sbjct: 2172 QELTTLRLQLEETDHQKNLLD----EELQRLKAEATEAARQR 2209


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 83/341 (24%), Positives = 149/341 (43%), Gaps = 50/341 (14%)

Query: 6    RERVQGSKQQLRLQFPPRIRKTPKLTFYRPDNILVKLNTTAILREGALYQR--------- 56
            ++R   + ++LRLQ     R+  +    R   + V L T     E  L  +         
Sbjct: 1558 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1617

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREE--------QLAASECRRLQGKLSH 108
            Q+E+ LQ     V    + +E    Q+    + REE        QL A+E  RL  +L  
Sbjct: 1618 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RLQA 1675

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
            EE V  ++SL Q   ++ +++ E+ A+   +  E+ +R+    +EL EQ +E Q+     
Sbjct: 1676 EE-VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ----RELAEQELEKQR----- 1725

Query: 169  QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC--ELISQLRALETQPTRKGKLV 226
              +LA+G   T Q+ +   + L++ RA+  Q EQ+R+   E +++L+      T+K +  
Sbjct: 1726 --QLAEG---TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ-- 1778

Query: 227  DLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQIS 286
                      E E  + ++R  + +L  ++ R EEE R    + K     E     E   
Sbjct: 1779 ----------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828

Query: 287  LCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRIS 327
               AA  R+ A   + ++ LA   AA  + E  + L  +++
Sbjct: 1829 --EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 60/248 (24%), Positives = 113/248 (45%), Gaps = 28/248 (11%)

Query: 119  MQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQ 178
            + E  +R+E++ E++A+        RL E  +  E   Q+ E    AKA   + AK  QQ
Sbjct: 1364 ISETLRRMEEE-ERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1422

Query: 179  TVQEAI---EESRGLLQRRAQAAQEE---QRRRCELISQLRALETQPTRKGKL------- 225
             +QE +   EE+    Q++ ++ QEE    R+  E   Q +A + +   + +L       
Sbjct: 1423 RMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR 1482

Query: 226  -----VDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQN 280
                 ++ T+    G EGE+  +  R   A  ++ Q ++E E+  + +Q +  + ++   
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ--- 1539

Query: 281  MVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
               ++ L       + A R E+++AL A      Q E  +   RR+ +   ER+RQ  + 
Sbjct: 1540 --AEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAE---RRLRQAEVERARQVQVA 1593

Query: 341  HVSAPRTA 348
              +A R+A
Sbjct: 1594 LETAQRSA 1601



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/350 (22%), Positives = 149/350 (42%), Gaps = 62/350 (17%)

Query: 45   TAILREGALYQRQVEQELQRVDKLVDGAGDFSEFFE-----WQKKMQAKDREEQLAASEC 99
            T +  E  L Q+Q E   ++  +L +     ++        +Q+ ++A+ + +   ++E 
Sbjct: 2350 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409

Query: 100  RRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAK------------------LMLQRA 141
             RL+ +++      AR    +E+ QR  +Q E++ +                  L +QR 
Sbjct: 2410 ERLKLRVAEMSRAQARA---EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2466

Query: 142  E-----RRLRE-----DRSRKELVEQV----IEGQKNAKAAQTKLAKGRQQTVQEAIEES 187
            +      RLRE     +R +++L ++     ++ ++     Q +L +  Q   Q  + E 
Sbjct: 2467 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2526

Query: 188  RGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRE 247
              LLQR  +   E+++ + E + Q    + Q  R+ +     Q+         S+ E R 
Sbjct: 2527 DSLLQR--ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584

Query: 248  RLALLKENQRRKEEEKR---DQIIQGKHTKSQELQNMVEQISLC----RAAMGRSAALRW 300
            R    +E  RRK+EE +    Q  Q +   ++E Q + EQ+ L     RAA+  S  +  
Sbjct: 2585 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644

Query: 301  EEKKALAA---------APAAPSQDER-VQQLRRRISERAAERSRQAALL 340
             +  A             PAA ++ E     LRR++S   A+R ++A +L
Sbjct: 2645 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVS---AQRLQEAGIL 2691



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 78/327 (23%), Positives = 141/327 (43%), Gaps = 38/327 (11%)

Query: 48   LREGALYQRQVEQE---LQRVDK---LVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR 101
            L E A  QRQ+ +E    QR +    L +      E    + + +   +E++      RR
Sbjct: 1836 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1895

Query: 102  LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR--LRED--RSRKELVEQ 157
            L    + +   L  Q+   ++K  +E++  Q+ K      ER+  L ED  R R+++ E+
Sbjct: 1896 LAEDEAFQRRRLEEQAA--QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953

Query: 158  VIEGQKN-----AKAAQTKLAKGR-----QQTVQEAIEESRGLLQRRAQAAQEEQRRR-- 205
            ++  + +     A  A+ +L  GR     + T++   +      ++R  AA+EE+RRR  
Sbjct: 1954 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREA 2013

Query: 206  CELISQLRALETQPT--RKGKLVDLTQIPGYGLEG----EMSIVELRERLALLKENQRRK 259
             E + +  A E +    RK  L ++ ++     E     E +  E   +L L +E  +++
Sbjct: 2014 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2073

Query: 260  EEEKRDQIIQGKHTKSQELQNMVEQISLC------RAAMGRSAALRWEEKKALAAAPAAP 313
             + +          K QELQ  ++Q           A   R AA   EE +  A   AA 
Sbjct: 2074 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2133

Query: 314  S--QDERVQQLRRRISERAAERSRQAA 338
            S  Q E  ++L++   E+A  R++  A
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQA 2160



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 59/261 (22%), Positives = 116/261 (44%), Gaps = 22/261 (8%)

Query: 86   QAKDREEQLAASECRRLQGKL-SHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERR 144
            QAK + E+ A    +R+Q ++   EEA +  Q   +  ++ ++Q ++     +  +A + 
Sbjct: 1408 QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1467

Query: 145  LREDRSRKELVEQ--VIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ 202
               +RSR  + E+  V+  Q  A   Q   A+G  Q ++   EE+     ++ QA +E +
Sbjct: 1468 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA---QKRQAQEEAE 1524

Query: 203  RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEE 262
            R R ++       E+Q  R+ ++   +++     + E      ++R     E  R + EE
Sbjct: 1525 RLRRQVQD-----ESQRKRQAEVELASRV-----KAEAEAAREKQRALQALEELRLQAEE 1574

Query: 263  KRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQL 322
               ++ Q +  +++++Q  +E       A  +S    + EK A     +   +   V QL
Sbjct: 1575 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA-QLERSLQEEHVAVAQL 1633

Query: 323  RRRISERA-----AERSRQAA 338
            R     RA     AER+R+ A
Sbjct: 1634 REEAERRAQQQAEAERAREEA 1654



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 61/290 (21%), Positives = 120/290 (41%), Gaps = 23/290 (7%)

Query: 57   QVEQELQRVDKLVDGAGDFSEFFEWQK---KMQAKDREEQLAASECRRLQGKLSHEEAVL 113
            QVEQEL  +   ++         + +    K +A +   Q +  E      ++  EE   
Sbjct: 2210 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2269

Query: 114  ARQSLMQENKQRVEQQKEQMAKLMLQRAE--RRLREDRSRKELVEQ--------VIEGQK 163
             +  +  EN+  + + K+   + + + AE  +++ E+ +R  +  Q          E   
Sbjct: 2270 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2329

Query: 164  NAKAAQTKLAKGRQQTVQEA--IEESRGLLQRRAQAAQEEQRR---RCELISQLRALETQ 218
              +A   K+ K + Q VQEA  ++    LLQ++ + AQE+ RR     E ++Q  A ETQ
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389

Query: 219  PTRKGKLVDLTQIPGYGLEGE---MSIVELRERLALLKENQR--RKEEEKRDQIIQGKHT 273
              ++    +  +      E E   + + E+    A  +E+ +  RK+ E+  + +     
Sbjct: 2390 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2449

Query: 274  KSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLR 323
             +QE   +V+ + + R      A    E    L        Q+ ++ QL+
Sbjct: 2450 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2499



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 73/342 (21%), Positives = 139/342 (40%), Gaps = 61/342 (17%)

Query: 46   AILREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRR---- 101
            A   + A  + ++E EL R+    +      E    Q +++A  R+ QLAA E RR    
Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLRSKE----QAELEAA-RQRQLAAEEERRRREA 2013

Query: 102  ---LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQV 158
               +Q  L+ EE    ++    E  +R++ + E+  +L  +  +   R+ +  +E  ++ 
Sbjct: 2014 EERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2073

Query: 159  IEGQKNAKA-AQTKLAKGRQQTVQE---AIEESRGLLQRRAQAAQEEQRRRCELISQLRA 214
            ++ ++ A A A  +  +  QQT+Q+    +++ RG  +   +AA+E +  R +   +   
Sbjct: 2074 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2133

Query: 215  LETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTK 274
               Q                        VE  ERL        ++  E++ Q        
Sbjct: 2134 SRRQ------------------------VEEAERL--------KQSAEEQAQARAQAQAA 2161

Query: 275  SQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERS 334
            +++L+   EQ    R A    AALR ++        AA ++ E+ ++   +   + A+  
Sbjct: 2162 AEKLRKEAEQ-EAARRAQAEQAALRQKQ--------AADAEMEKHKKFAEQTLRQKAQVE 2212

Query: 335  RQAALLHVSAPRTARPKPRVSPDWWEEPGRLKAGAGWGWRAR 376
            ++   L +    T   K  +     EE  RLKA A    R R
Sbjct: 2213 QELTTLRLQLEETDHQKNLLD----EELQRLKAEATEAARQR 2250


>gi|219803769 trichoplein [Homo sapiens]
          Length = 498

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 83/340 (24%), Positives = 145/340 (42%), Gaps = 39/340 (11%)

Query: 53  LYQRQVEQ--ELQRVDKLVDGAGDFSEFFEWQKKMQAKDRE--EQLAASECRR-LQGKLS 107
           L+Q+ V    E+Q+ +K    A    E   ++ + +   RE  E++ A E RR L+ KL 
Sbjct: 157 LHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQ 216

Query: 108 HEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAE-RRLREDRSRKELVEQVIEGQKNAK 166
            E  +   + L  +  +  + +KEQ   L+ QR E  RL E+R + E   Q  E  +  +
Sbjct: 217 AEALLQQMEELKLKEVEATKLKKEQ-ENLLKQRWELERLEEERKQMEAFRQKAELGRFLR 275

Query: 167 AAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQR----RRCELISQL--------RA 214
                    R Q +QE +E  R +LQ   +   E QR    RR ++++ +          
Sbjct: 276 HQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQ 335

Query: 215 LETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLA---LLKENQRRKEEEKRDQIIQGK 271
           L+ +  R+ +L  L +     +  +      RER A   L+ E    ++++ +++I Q +
Sbjct: 336 LQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNR 395

Query: 272 HTKSQEL-------QNMVEQISLCRAAMGRSAALRWEEKKALAAAPA--------APSQD 316
             + + L       +N+ E   L R     S  L+   K+ L A  A        A  Q+
Sbjct: 396 RAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQE 455

Query: 317 ERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSP 356
           E  ++  RR+ + +    +Q A     A +  RPKP   P
Sbjct: 456 EEEEEEARRVEQLSDALLQQEA--ETMAEQGYRPKPYGHP 493



 Score = 37.0 bits (84), Expect = 0.037
 Identities = 57/264 (21%), Positives = 120/264 (45%), Gaps = 20/264 (7%)

Query: 83  KKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAE 142
           K+ Q K   EQL     ++   KL   E  L ++ ++   + + E++K+Q A    +   
Sbjct: 127 KEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKR 186

Query: 143 RRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ 202
                +R+R+E +E+ ++ ++  +  + KL   + + + + +EE + L +  A   ++EQ
Sbjct: 187 YENEYERARREALER-MKAEEERRQLEDKL---QAEALLQQMEELK-LKEVEATKLKKEQ 241

Query: 203 RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMS-IVELRERLALLKENQRRKEE 261
               +   +L  LE +  RK       Q+  +  + E+   +  +    L +  Q+ +EE
Sbjct: 242 ENLLKQRWELERLEEE--RK-------QMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE 292

Query: 262 EKRD-QIIQGKHTKSQELQNM----VEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQD 316
            + D +I+Q    K  E Q +     EQ+    A M ++   + + ++A  A      ++
Sbjct: 293 LEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLRE 352

Query: 317 ERVQQLRRRISERAAERSRQAALL 340
           E  +   +R +E A ERS +  L+
Sbjct: 353 EAKEMWEKREAEWARERSARDRLM 376


>gi|14150056 trichoplein [Homo sapiens]
          Length = 498

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 83/340 (24%), Positives = 145/340 (42%), Gaps = 39/340 (11%)

Query: 53  LYQRQVEQ--ELQRVDKLVDGAGDFSEFFEWQKKMQAKDRE--EQLAASECRR-LQGKLS 107
           L+Q+ V    E+Q+ +K    A    E   ++ + +   RE  E++ A E RR L+ KL 
Sbjct: 157 LHQKHVVNSWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQ 216

Query: 108 HEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAE-RRLREDRSRKELVEQVIEGQKNAK 166
            E  +   + L  +  +  + +KEQ   L+ QR E  RL E+R + E   Q  E  +  +
Sbjct: 217 AEALLQQMEELKLKEVEATKLKKEQ-ENLLKQRWELERLEEERKQMEAFRQKAELGRFLR 275

Query: 167 AAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQR----RRCELISQL--------RA 214
                    R Q +QE +E  R +LQ   +   E QR    RR ++++ +          
Sbjct: 276 HQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQ 335

Query: 215 LETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLA---LLKENQRRKEEEKRDQIIQGK 271
           L+ +  R+ +L  L +     +  +      RER A   L+ E    ++++ +++I Q +
Sbjct: 336 LQLERAREAELQMLLREEAKEMWEKREAEWARERSARDRLMSEVLTGRQQQIQEKIEQNR 395

Query: 272 HTKSQEL-------QNMVEQISLCRAAMGRSAALRWEEKKALAAAPA--------APSQD 316
             + + L       +N+ E   L R     S  L+   K+ L A  A        A  Q+
Sbjct: 396 RAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQELEAQVAERRLQAWEADQQE 455

Query: 317 ERVQQLRRRISERAAERSRQAALLHVSAPRTARPKPRVSP 356
           E  ++  RR+ + +    +Q A     A +  RPKP   P
Sbjct: 456 EEEEEEARRVEQLSDALLQQEA--ETMAEQGYRPKPYGHP 493



 Score = 37.0 bits (84), Expect = 0.037
 Identities = 57/264 (21%), Positives = 120/264 (45%), Gaps = 20/264 (7%)

Query: 83  KKMQAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAE 142
           K+ Q K   EQL     ++   KL   E  L ++ ++   + + E++K+Q A    +   
Sbjct: 127 KEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATAEQENKR 186

Query: 143 RRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ 202
                +R+R+E +E+ ++ ++  +  + KL   + + + + +EE + L +  A   ++EQ
Sbjct: 187 YENEYERARREALER-MKAEEERRQLEDKL---QAEALLQQMEELK-LKEVEATKLKKEQ 241

Query: 203 RRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMS-IVELRERLALLKENQRRKEE 261
               +   +L  LE +  RK       Q+  +  + E+   +  +    L +  Q+ +EE
Sbjct: 242 ENLLKQRWELERLEEE--RK-------QMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEE 292

Query: 262 EKRD-QIIQGKHTKSQELQNM----VEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQD 316
            + D +I+Q    K  E Q +     EQ+    A M ++   + + ++A  A      ++
Sbjct: 293 LEADRRILQALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLRE 352

Query: 317 ERVQQLRRRISERAAERSRQAALL 340
           E  +   +R +E A ERS +  L+
Sbjct: 353 EAKEMWEKREAEWARERSARDRLM 376


>gi|239756174 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 625

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 52/205 (25%), Positives = 87/205 (42%), Gaps = 8/205 (3%)

Query: 80  EWQKKMQAKDREEQLAASECRRLQGKLSHEE--AVLARQSLMQENKQRVEQQKEQMAKLM 137
           E ++K +A ++  +  A++    +G+   EE  A   RQ   + +++R  +  E+   L 
Sbjct: 395 EEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLR 454

Query: 138 LQRAERRLREDRSRKELVEQVI----EGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQR 193
            +RAER  REDR RK   EQ +    EG +  +    ++ + R Q    A +   G LQR
Sbjct: 455 RERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQR 514

Query: 194 RAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEG--EMSIVELRERLAL 251
             +     +R R E + Q R  + +  R+G    L    G   E    ++I    ER   
Sbjct: 515 EKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQ 574

Query: 252 LKENQRRKEEEKRDQIIQGKHTKSQ 276
           L   +R   E  R       H + +
Sbjct: 575 LTRERRSALESARSTARASFHVREK 599



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 62/244 (25%), Positives = 103/244 (42%), Gaps = 23/244 (9%)

Query: 120 QENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQT 179
           QE    +EQ+     +  LQR   + R +R  +E  ++ +E  + A AAQ +  +GR+  
Sbjct: 365 QEELLLLEQRAAAHGQWELQRVHAKQRREREERE-KQRALEQGRRAWAAQVEERRGRRG- 422

Query: 180 VQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGE 239
                 E R   +RR +  +  + RR EL  +   L  +   +    D  +     L+ E
Sbjct: 423 -----REEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLR----KLQQE 473

Query: 240 MSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKS-QELQNMVEQISLCRAAMGRSAAL 298
            +   L++R   L+E + R E+ +R++  +    K  QE Q   E+  L RA   R  AL
Sbjct: 474 QN---LKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEAL 530

Query: 299 -------RWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPK 351
                  + +E++ L ++  A S     +        R  ERS Q      SA  +AR  
Sbjct: 531 LQGRTRQQRQEREGLRSSLEA-SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARST 589

Query: 352 PRVS 355
            R S
Sbjct: 590 ARAS 593



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 68/304 (22%), Positives = 129/304 (42%), Gaps = 21/304 (6%)

Query: 57  QVEQELQRVDKLVDGAGDFSEFFEWQKK----MQAKDREEQLAASECRRLQGK--LSHEE 110
           Q  Q ++R+ + V          E  +K    M A+ +EE L   +     G+  L    
Sbjct: 328 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 387

Query: 111 AVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDR--SRKELVEQVIEGQKNAKAA 168
           A   R+   +E ++ +EQ +   A  + +R  RR RE+R  +R+   +     ++  + A
Sbjct: 388 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 447

Query: 169 QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ-----RRRCELISQLRALETQPTRKG 223
           + +    R++  + A E+    LQ+     Q E+     R R E I + RA      ++ 
Sbjct: 448 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 507

Query: 224 KLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVE 283
           +   L +      + E+S  E R R   L + + R++ ++R+ +           Q   E
Sbjct: 508 QEGQLQR-----EKRELSRAE-RARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 561

Query: 284 QISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERV-QQLRRRISERAAERSRQAALLHV 342
            +++ R  + RS  L  E + AL +A +       V +++R   + R+ +R  + A LH 
Sbjct: 562 HLAIGR-KLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHA 620

Query: 343 SAPR 346
           S  R
Sbjct: 621 SLDR 624


>gi|239750672 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 627

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 52/205 (25%), Positives = 87/205 (42%), Gaps = 8/205 (3%)

Query: 80  EWQKKMQAKDREEQLAASECRRLQGKLSHEE--AVLARQSLMQENKQRVEQQKEQMAKLM 137
           E ++K +A ++  +  A++    +G+   EE  A   RQ   + +++R  +  E+   L 
Sbjct: 397 EEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLR 456

Query: 138 LQRAERRLREDRSRKELVEQVI----EGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQR 193
            +RAER  REDR RK   EQ +    EG +  +    ++ + R Q    A +   G LQR
Sbjct: 457 RERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQR 516

Query: 194 RAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEG--EMSIVELRERLAL 251
             +     +R R E + Q R  + +  R+G    L    G   E    ++I    ER   
Sbjct: 517 EKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQ 576

Query: 252 LKENQRRKEEEKRDQIIQGKHTKSQ 276
           L   +R   E  R       H + +
Sbjct: 577 LTRERRSALESARSTARASFHVREK 601



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 62/244 (25%), Positives = 103/244 (42%), Gaps = 23/244 (9%)

Query: 120 QENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQT 179
           QE    +EQ+     +  LQR   + R +R  +E  ++ +E  + A AAQ +  +GR+  
Sbjct: 367 QEELLLLEQRAAAHGQWELQRVHAKQRREREERE-KQRALEQGRRAWAAQVEERRGRRG- 424

Query: 180 VQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGE 239
                 E R   +RR +  +  + RR EL  +   L  +   +    D  +     L+ E
Sbjct: 425 -----REEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLR----KLQQE 475

Query: 240 MSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKS-QELQNMVEQISLCRAAMGRSAAL 298
            +   L++R   L+E + R E+ +R++  +    K  QE Q   E+  L RA   R  AL
Sbjct: 476 QN---LKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEAL 532

Query: 299 -------RWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPK 351
                  + +E++ L ++  A S     +        R  ERS Q      SA  +AR  
Sbjct: 533 LQGRTRQQRQEREGLRSSLEA-SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARST 591

Query: 352 PRVS 355
            R S
Sbjct: 592 ARAS 595



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 68/304 (22%), Positives = 129/304 (42%), Gaps = 21/304 (6%)

Query: 57  QVEQELQRVDKLVDGAGDFSEFFEWQKK----MQAKDREEQLAASECRRLQGK--LSHEE 110
           Q  Q ++R+ + V          E  +K    M A+ +EE L   +     G+  L    
Sbjct: 330 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 389

Query: 111 AVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDR--SRKELVEQVIEGQKNAKAA 168
           A   R+   +E ++ +EQ +   A  + +R  RR RE+R  +R+   +     ++  + A
Sbjct: 390 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 449

Query: 169 QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ-----RRRCELISQLRALETQPTRKG 223
           + +    R++  + A E+    LQ+     Q E+     R R E I + RA      ++ 
Sbjct: 450 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 509

Query: 224 KLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVE 283
           +   L +      + E+S  E R R   L + + R++ ++R+ +           Q   E
Sbjct: 510 QEGQLQR-----EKRELSRAE-RARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563

Query: 284 QISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERV-QQLRRRISERAAERSRQAALLHV 342
            +++ R  + RS  L  E + AL +A +       V +++R   + R+ +R  + A LH 
Sbjct: 564 HLAIGR-KLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHA 622

Query: 343 SAPR 346
           S  R
Sbjct: 623 SLDR 626


>gi|239744982 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 627

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 52/205 (25%), Positives = 87/205 (42%), Gaps = 8/205 (3%)

Query: 80  EWQKKMQAKDREEQLAASECRRLQGKLSHEE--AVLARQSLMQENKQRVEQQKEQMAKLM 137
           E ++K +A ++  +  A++    +G+   EE  A   RQ   + +++R  +  E+   L 
Sbjct: 397 EEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELAERQGLLR 456

Query: 138 LQRAERRLREDRSRKELVEQVI----EGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQR 193
            +RAER  REDR RK   EQ +    EG +  +    ++ + R Q    A +   G LQR
Sbjct: 457 RERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQR 516

Query: 194 RAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEG--EMSIVELRERLAL 251
             +     +R R E + Q R  + +  R+G    L    G   E    ++I    ER   
Sbjct: 517 EKRELSRAERARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYEHLAIGRKLERSEQ 576

Query: 252 LKENQRRKEEEKRDQIIQGKHTKSQ 276
           L   +R   E  R       H + +
Sbjct: 577 LTRERRSALESARSTARASFHVREK 601



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 62/244 (25%), Positives = 103/244 (42%), Gaps = 23/244 (9%)

Query: 120 QENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQT 179
           QE    +EQ+     +  LQR   + R +R  +E  ++ +E  + A AAQ +  +GR+  
Sbjct: 367 QEELLLLEQRAAAHGQWELQRVHAKQRREREERE-KQRALEQGRRAWAAQVEERRGRRG- 424

Query: 180 VQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGE 239
                 E R   +RR +  +  + RR EL  +   L  +   +    D  +     L+ E
Sbjct: 425 -----REEREAARRRQRQYERSEERRRELAERQGLLRRERAERAAREDRLR----KLQQE 475

Query: 240 MSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKS-QELQNMVEQISLCRAAMGRSAAL 298
            +   L++R   L+E + R E+ +R++  +    K  QE Q   E+  L RA   R  AL
Sbjct: 476 QN---LKQREEGLQEGRERAEQIRRERAQRAARAKQRQEGQLQREKRELSRAERARHEAL 532

Query: 299 -------RWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALLHVSAPRTARPK 351
                  + +E++ L ++  A S     +        R  ERS Q      SA  +AR  
Sbjct: 533 LQGRTRQQRQEREGLRSSLEA-SLGRAQENYEHLAIGRKLERSEQLTRERRSALESARST 591

Query: 352 PRVS 355
            R S
Sbjct: 592 ARAS 595



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 68/304 (22%), Positives = 129/304 (42%), Gaps = 21/304 (6%)

Query: 57  QVEQELQRVDKLVDGAGDFSEFFEWQKK----MQAKDREEQLAASECRRLQGK--LSHEE 110
           Q  Q ++R+ + V          E  +K    M A+ +EE L   +     G+  L    
Sbjct: 330 QTAQHVERIVRQVRAERGLRGVPERDRKIAALMLARHQEELLLLEQRAAAHGQWELQRVH 389

Query: 111 AVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDR--SRKELVEQVIEGQKNAKAA 168
           A   R+   +E ++ +EQ +   A  + +R  RR RE+R  +R+   +     ++  + A
Sbjct: 390 AKQRREREEREKQRALEQGRRAWAAQVEERRGRRGREEREAARRRQRQYERSEERRRELA 449

Query: 169 QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQ-----RRRCELISQLRALETQPTRKG 223
           + +    R++  + A E+    LQ+     Q E+     R R E I + RA      ++ 
Sbjct: 450 ERQGLLRRERAERAAREDRLRKLQQEQNLKQREEGLQEGRERAEQIRRERAQRAARAKQR 509

Query: 224 KLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVE 283
           +   L +      + E+S  E R R   L + + R++ ++R+ +           Q   E
Sbjct: 510 QEGQLQR-----EKRELSRAE-RARHEALLQGRTRQQRQEREGLRSSLEASLGRAQENYE 563

Query: 284 QISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERV-QQLRRRISERAAERSRQAALLHV 342
            +++ R  + RS  L  E + AL +A +       V +++R   + R+ +R  + A LH 
Sbjct: 564 HLAIGR-KLERSEQLTRERRSALESARSTARASFHVREKVREETNTRSFDRMVREAQLHA 622

Query: 343 SAPR 346
           S  R
Sbjct: 623 SLDR 626


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 70/321 (21%), Positives = 145/321 (45%), Gaps = 34/321 (10%)

Query: 50   EGALYQRQVEQELQRVDKLVDGAGDFSEF-FEWQKKMQAKDREEQL---AASECRRLQGK 105
            E + +   ++ EL+++DKL            E +++++  +RE Q    A  E +RLQ +
Sbjct: 1367 EASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQR 1426

Query: 106  LS--HEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQK 163
            L+   +E   AR+ +    K  ++Q  +Q  +  L R +  L E++ R++L+E  +E  +
Sbjct: 1427 LAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQ--LEEEQHRRQLLEGELETLR 1484

Query: 164  NAKAAQTKLAKGRQQTVQEAIEESRG----LLQRRAQAAQEEQRRRCELISQLRALETQP 219
               AA  K     +  + E+++  +G     +QR   + +EE R + EL  ++  LE + 
Sbjct: 1485 RKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEAR- 1543

Query: 220  TRKGKLVDLTQIPGYGLEGEMSIVELRERLALLK-ENQRRKEEEKRDQI-IQGKHTKSQE 277
                    L+++  +  +    +  LRE    L+ E Q  + E +R Q  I    T++++
Sbjct: 1544 --------LSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRD 1595

Query: 278  LQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERS--- 334
            L+NM    ++  +     + L   E++       +  +D  + +L++R+   A +R    
Sbjct: 1596 LRNM----TVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRE 1651

Query: 335  ----RQAALLHVSAPRTARPK 351
                R   ++H    R   P+
Sbjct: 1652 NHLRRSIVVIHPDTGRELSPE 1672



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 70/321 (21%), Positives = 135/321 (42%), Gaps = 55/321 (17%)

Query: 57   QVEQELQRV-DKLVDGAGDFS----EFFEWQKKMQA-KDREEQLAASECRR-----LQGK 105
            ++E+ELQR+ +++VD          E ++ +K++QA KD + Q+   E  +      +  
Sbjct: 1243 EMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDP 1302

Query: 106  LSHEEAVLARQSLMQENKQRVEQQKEQMAKL-MLQRAERRLREDRSRKELVEQVI---EG 161
             + EE    R  L +E K++V+ ++E+ ++   + R E  L   R ++ +V+Q +   E 
Sbjct: 1303 QTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEEL--SRVKERVVQQEVVRYEE 1360

Query: 162  QKNAKAAQTKLAKG----------------RQQTVQEAIEESRGLLQRRAQAAQEEQRRR 205
            +   +A  +  A+                 R Q  +  +E     L+R  QA +E +R  
Sbjct: 1361 EPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREV 1420

Query: 206  CELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRD 265
              L  +L ALE +     + V  TQ      + + +      RL L       +EE+ R 
Sbjct: 1421 QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQL-------EEEQHRR 1473

Query: 266  QIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRR 325
            Q+++G      EL+ +  +++    A         E K+ +  + +   +    +Q  +R
Sbjct: 1474 QLLEG------ELETLRRKLAALEKA---------EVKEKVVLSESVQVEKGDTEQEIQR 1518

Query: 326  ISERAAERSRQAALLHVSAPR 346
            +     E SR    L V   R
Sbjct: 1519 LKSSLEEESRSKRELDVEVSR 1539



 Score = 38.1 bits (87), Expect = 0.017
 Identities = 55/257 (21%), Positives = 117/257 (45%), Gaps = 24/257 (9%)

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQ-RAERRLREDRSRKELVEQVIEGQKNAKA 167
            EE+    Q  + E + + +  +E++  L LQ RA  +   D  ++ +V++V+  + + +A
Sbjct: 947  EESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RA 1005

Query: 168  AQTKLAKGRQQTVQEAIEESRG-------LLQRRAQAAQEEQRRRCELISQLRALETQPT 220
               ++ + R++   EA+   +G       LLQ+R  A  EE+ R  E +++   ++ Q  
Sbjct: 1006 QADEVLQLREEL--EALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQND 1063

Query: 221  RKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQN 280
             + +  +  Q+       +    +  E L+ L++  +R E+E+   + +GK T  + L+ 
Sbjct: 1064 PQLE-AEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKER--AMAEGKITVKEVLK- 1119

Query: 281  MVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
             VE+ +     +      ++E++    AA A  SQ E+ + LR+     A E      ++
Sbjct: 1120 -VEKDAATEREVS-DLTRQYEDE----AAKARASQREKTELLRK---IWALEEENAKVVV 1170

Query: 341  HVSAPRTARPKPRVSPD 357
                    RP P+   +
Sbjct: 1171 QEKVREIVRPDPKAESE 1187


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 71/298 (23%), Positives = 132/298 (44%), Gaps = 27/298 (9%)

Query: 49   REGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSH 108
            +E    +R +E EL+         G+ S+  + QK++  K +EE     + RRL+ ++ +
Sbjct: 888  KEAVSARRALENELEAAQ------GNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMEN 941

Query: 109  EEAVLAR--QSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAK 166
            E   L +  + L +E    VE  +    +L  Q  E + +  R   E+  Q+ E  K  +
Sbjct: 942  ERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKE--KTLE 999

Query: 167  AAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQ-LRALETQPTRKGKL 225
            A +++L   + Q     +EE      R  Q AQ+E   + +L+ Q L+ LE +   K  L
Sbjct: 1000 AEKSRLTAMKMQDEMRLMEEE----LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHL 1055

Query: 226  VD-----LTQIPGYGLEGEMSIVELRERLALLKE---NQRRKEEEKRDQIIQGKHTKSQE 277
             D     + Q+     + EM + E R    LL E     R + E+ R++++Q +  + Q+
Sbjct: 1056 KDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAAR-QD 1114

Query: 278  LQNMVEQISLCRAAMG-RSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERS 334
            L+   ++ISL R     +S  +  E     +        + R+ +L  R+     +R+
Sbjct: 1115 LE--CDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRA 1170



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 66/314 (21%), Positives = 138/314 (43%), Gaps = 61/314 (19%)

Query: 77  EFFEWQKKMQAKDREEQLAASECRRLQGKLS-----HEEAVLARQSLMQ---ENKQRVEQ 128
           E  E Q+++Q + + +Q    E  R++  L      H E V    +L Q   E++  + +
Sbjct: 622 EVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRK 681

Query: 129 QKEQMAKLMLQRAERRLR---------------------EDRSRKELVEQVIEGQKN--- 164
             E++ ++ ++R + +                       EDR +  L+E++++ +++   
Sbjct: 682 NLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQD 741

Query: 165 ---AKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTR 221
              AK  Q  L + R+   +E       L +  +   QE  + + +  ++L+AL      
Sbjct: 742 LLIAKEEQEDLLRKRE---RELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEE 798

Query: 222 KGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQR---RKEE--------EKRDQIIQG 270
             K V++        E + +  E+R +L L +EN++   R EE        +++ + ++G
Sbjct: 799 ATKNVEVLASRSNTSEQDQAGTEMRVKL-LQEENEKLQGRSEELERRVAQLQRQIEDLKG 857

Query: 271 KHTKSQE-LQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQ-------QL 322
              K++E L+    +I     A+  +   R EEK+A++A  A  ++ E  Q       Q 
Sbjct: 858 DEAKAKETLKKYEGEIRQLEEALVHA---RKEEKEAVSARRALENELEAAQGNLSQTTQE 914

Query: 323 RRRISERAAERSRQ 336
           ++++SE+  E S Q
Sbjct: 915 QKQLSEKLKEESEQ 928



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 52/257 (20%), Positives = 95/257 (36%), Gaps = 48/257 (18%)

Query: 102 LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEG 161
           L+ + S E  V+   SL  ++K+  E+ K   A LMLQ        D   K++  +    
Sbjct: 471 LETEGSQESTVIRAPSLGAQSKKE-EEVKTATATLMLQNRATATSPDSGAKKISVKTFPS 529

Query: 162 QKNAKAAQTKLAKGRQQTVQEAIEESRG------------------------------LL 191
             N +A    L KG+Q+  Q+  EE+                                 L
Sbjct: 530 ASNTQATPD-LLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTL 588

Query: 192 QRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLAL 251
           + RA  + +   + C   S+++ L  Q   K KL              + + EL+ +L L
Sbjct: 589 KSRAAGSAQGNNQACNSTSEVKDLLEQ---KSKLT-------------IEVAELQRQLQL 632

Query: 252 LKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPA 311
             +NQ+  +EE+       +  +SQ  + + E  +L +        LR   ++       
Sbjct: 633 EVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKME 692

Query: 312 APSQDERVQQLRRRISE 328
                  ++ L+ ++SE
Sbjct: 693 REQHQTEIRDLQDQLSE 709


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sapiens]
          Length = 1293

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 74/312 (23%), Positives = 139/312 (44%), Gaps = 30/312 (9%)

Query: 49   REGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSH 108
            RE  +  ++ E+E +R ++L        E    Q++ + K REE+  A   RR Q     
Sbjct: 736  REAEMRAKREEEERKRQEEL---RRQQEEILRRQQEEERKRREEEELA---RRKQ----- 784

Query: 109  EEAVLA-RQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRK--ELV----EQVIEG 161
            EEA+   R+  +   +QR E++++Q  + + +  ERR  E+  RK  EL+    E+  + 
Sbjct: 785  EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 844

Query: 162  QKNAKAAQTKLAKGRQQTVQEAI-----EESRGLLQRRAQAAQEEQRRRCELISQLRALE 216
             +  + AQ +L + R +  +EA      EE R   +   Q  +E  R+R +    LR L+
Sbjct: 845  AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQ 904

Query: 217  TQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQ 276
             Q  ++ +L  + ++P     G+ S     +  A L   + +K EE+R++ ++ +  + Q
Sbjct: 905  QQQQQQ-QLAQM-KLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQ 962

Query: 277  E-----LQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAA 331
                  LQ   +Q     +  G  +      K  L        Q ++ QQ +++  +   
Sbjct: 963  RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1022

Query: 332  ERSRQAALLHVS 343
             R+   + LH S
Sbjct: 1023 ARNNTHSNLHTS 1034



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 54/265 (20%), Positives = 119/265 (44%), Gaps = 23/265 (8%)

Query: 87  AKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLR 146
           A ++ +QL  ++  +L+ +    E    R+   ++ ++ + +Q+E++ +   +   +R  
Sbjct: 716 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 775

Query: 147 EDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC 206
           E+   +   E+ +  Q+     + ++A  RQ+  +E  ++   L +   +  +EE+RR+ 
Sbjct: 776 EEELARRKQEEALRRQR-----EQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 830

Query: 207 ELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKE-EEKRD 265
           E +  LR  E +  +  +  +  Q      E  + + E   RL   +E ++RKE E +R 
Sbjct: 831 EEL--LRKQEEEAAKWAREEEEAQ--RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 886

Query: 266 QIIQGKHTKSQE----LQNMVEQISLCRAAMGRSA-------ALRWEEKKALAAAPAAPS 314
           + +  +  + QE    LQ   +Q  L +  +  S+           + +  L+ A     
Sbjct: 887 KELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL 946

Query: 315 QDERVQQLRRRISERAAERSRQAAL 339
           ++ER +QLR    +R  +R    AL
Sbjct: 947 EEERERQLRE--EQRRQQRELMKAL 969


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
          Length = 1320

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 74/312 (23%), Positives = 139/312 (44%), Gaps = 30/312 (9%)

Query: 49   REGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSH 108
            RE  +  ++ E+E +R ++L        E    Q++ + K REE+  A   RR Q     
Sbjct: 763  REAEMRAKREEEERKRQEEL---RRQQEEILRRQQEEERKRREEEELA---RRKQ----- 811

Query: 109  EEAVLA-RQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRK--ELV----EQVIEG 161
            EEA+   R+  +   +QR E++++Q  + + +  ERR  E+  RK  EL+    E+  + 
Sbjct: 812  EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 871

Query: 162  QKNAKAAQTKLAKGRQQTVQEAI-----EESRGLLQRRAQAAQEEQRRRCELISQLRALE 216
             +  + AQ +L + R +  +EA      EE R   +   Q  +E  R+R +    LR L+
Sbjct: 872  AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQ 931

Query: 217  TQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQ 276
             Q  ++ +L  + ++P     G+ S     +  A L   + +K EE+R++ ++ +  + Q
Sbjct: 932  QQQQQQ-QLAQM-KLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQ 989

Query: 277  E-----LQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAA 331
                  LQ   +Q     +  G  +      K  L        Q ++ QQ +++  +   
Sbjct: 990  RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1049

Query: 332  ERSRQAALLHVS 343
             R+   + LH S
Sbjct: 1050 ARNNTHSNLHTS 1061



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 54/265 (20%), Positives = 119/265 (44%), Gaps = 23/265 (8%)

Query: 87  AKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLR 146
           A ++ +QL  ++  +L+ +    E    R+   ++ ++ + +Q+E++ +   +   +R  
Sbjct: 743 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 802

Query: 147 EDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC 206
           E+   +   E+ +  Q+     + ++A  RQ+  +E  ++   L +   +  +EE+RR+ 
Sbjct: 803 EEELARRKQEEALRRQR-----EQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 857

Query: 207 ELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKE-EEKRD 265
           E +  LR  E +  +  +  +  Q      E  + + E   RL   +E ++RKE E +R 
Sbjct: 858 EEL--LRKQEEEAAKWAREEEEAQ--RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 913

Query: 266 QIIQGKHTKSQE----LQNMVEQISLCRAAMGRSA-------ALRWEEKKALAAAPAAPS 314
           + +  +  + QE    LQ   +Q  L +  +  S+           + +  L+ A     
Sbjct: 914 KELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL 973

Query: 315 QDERVQQLRRRISERAAERSRQAAL 339
           ++ER +QLR    +R  +R    AL
Sbjct: 974 EEERERQLRE--EQRRQQRELMKAL 996


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
          Length = 1299

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 74/312 (23%), Positives = 139/312 (44%), Gaps = 30/312 (9%)

Query: 49   REGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSH 108
            RE  +  ++ E+E +R ++L        E    Q++ + K REE+  A   RR Q     
Sbjct: 742  REAEMRAKREEEERKRQEEL---RRQQEEILRRQQEEERKRREEEELA---RRKQ----- 790

Query: 109  EEAVLA-RQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRK--ELV----EQVIEG 161
            EEA+   R+  +   +QR E++++Q  + + +  ERR  E+  RK  EL+    E+  + 
Sbjct: 791  EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 850

Query: 162  QKNAKAAQTKLAKGRQQTVQEAI-----EESRGLLQRRAQAAQEEQRRRCELISQLRALE 216
             +  + AQ +L + R +  +EA      EE R   +   Q  +E  R+R +    LR L+
Sbjct: 851  AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQ 910

Query: 217  TQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQ 276
             Q  ++ +L  + ++P     G+ S     +  A L   + +K EE+R++ ++ +  + Q
Sbjct: 911  QQQQQQ-QLAQM-KLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQ 968

Query: 277  E-----LQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAA 331
                  LQ   +Q     +  G  +      K  L        Q ++ QQ +++  +   
Sbjct: 969  RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1028

Query: 332  ERSRQAALLHVS 343
             R+   + LH S
Sbjct: 1029 ARNNTHSNLHTS 1040



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 54/265 (20%), Positives = 119/265 (44%), Gaps = 23/265 (8%)

Query: 87  AKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLR 146
           A ++ +QL  ++  +L+ +    E    R+   ++ ++ + +Q+E++ +   +   +R  
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781

Query: 147 EDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC 206
           E+   +   E+ +  Q+     + ++A  RQ+  +E  ++   L +   +  +EE+RR+ 
Sbjct: 782 EEELARRKQEEALRRQR-----EQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 836

Query: 207 ELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKE-EEKRD 265
           E +  LR  E +  +  +  +  Q      E  + + E   RL   +E ++RKE E +R 
Sbjct: 837 EEL--LRKQEEEAAKWAREEEEAQ--RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 892

Query: 266 QIIQGKHTKSQE----LQNMVEQISLCRAAMGRSA-------ALRWEEKKALAAAPAAPS 314
           + +  +  + QE    LQ   +Q  L +  +  S+           + +  L+ A     
Sbjct: 893 KELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL 952

Query: 315 QDERVQQLRRRISERAAERSRQAAL 339
           ++ER +QLR    +R  +R    AL
Sbjct: 953 EEERERQLRE--EQRRQQRELMKAL 975


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
          Length = 1299

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 74/312 (23%), Positives = 139/312 (44%), Gaps = 30/312 (9%)

Query: 49   REGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSH 108
            RE  +  ++ E+E +R ++L        E    Q++ + K REE+  A   RR Q     
Sbjct: 742  REAEMRAKREEEERKRQEEL---RRQQEEILRRQQEEERKRREEEELA---RRKQ----- 790

Query: 109  EEAVLA-RQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRK--ELV----EQVIEG 161
            EEA+   R+  +   +QR E++++Q  + + +  ERR  E+  RK  EL+    E+  + 
Sbjct: 791  EEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW 850

Query: 162  QKNAKAAQTKLAKGRQQTVQEAI-----EESRGLLQRRAQAAQEEQRRRCELISQLRALE 216
             +  + AQ +L + R +  +EA      EE R   +   Q  +E  R+R +    LR L+
Sbjct: 851  AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQ 910

Query: 217  TQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQ 276
             Q  ++ +L  + ++P     G+ S     +  A L   + +K EE+R++ ++ +  + Q
Sbjct: 911  QQQQQQ-QLAQM-KLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQ 968

Query: 277  E-----LQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAA 331
                  LQ   +Q     +  G  +      K  L        Q ++ QQ +++  +   
Sbjct: 969  RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNR 1028

Query: 332  ERSRQAALLHVS 343
             R+   + LH S
Sbjct: 1029 ARNNTHSNLHTS 1040



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 54/265 (20%), Positives = 119/265 (44%), Gaps = 23/265 (8%)

Query: 87  AKDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLR 146
           A ++ +QL  ++  +L+ +    E    R+   ++ ++ + +Q+E++ +   +   +R  
Sbjct: 722 ALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRRE 781

Query: 147 EDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRC 206
           E+   +   E+ +  Q+     + ++A  RQ+  +E  ++   L +   +  +EE+RR+ 
Sbjct: 782 EEELARRKQEEALRRQR-----EQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQ 836

Query: 207 ELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKE-EEKRD 265
           E +  LR  E +  +  +  +  Q      E  + + E   RL   +E ++RKE E +R 
Sbjct: 837 EEL--LRKQEEEAAKWAREEEEAQ--RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 892

Query: 266 QIIQGKHTKSQE----LQNMVEQISLCRAAMGRSA-------ALRWEEKKALAAAPAAPS 314
           + +  +  + QE    LQ   +Q  L +  +  S+           + +  L+ A     
Sbjct: 893 KELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL 952

Query: 315 QDERVQQLRRRISERAAERSRQAAL 339
           ++ER +QLR    +R  +R    AL
Sbjct: 953 EEERERQLRE--EQRRQQRELMKAL 975


>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
          Length = 3899

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 64/288 (22%), Positives = 124/288 (43%), Gaps = 23/288 (7%)

Query: 48   LREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQ--KKMQAKDREEQLAASECRRLQGK 105
            L E +  + Q+  EL + + ++DG  D    FE Q  +K    DR EQ       RLQ  
Sbjct: 1903 LHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQEL 1962

Query: 106  LSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEG-QKN 164
             + ++ +   + L+   K+ ++ +   + + +LQ  E+ ++E    +   E+V +  QK 
Sbjct: 1963 EAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQ 2022

Query: 165  AKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQ-AAQEEQRRRCELISQLRALETQPTRKG 223
             KA +  + +   + ++   E++  L+  R Q  A E+Q  +       +A++ +  R  
Sbjct: 2023 VKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHER-- 2080

Query: 224  KLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEE----------EKRDQIIQGKHT 273
               D+ Q     LE ++ +V    R   + E+Q R+ E          +K  +++  K  
Sbjct: 2081 ---DVFQQEIQKLEQQLKVV---PRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQ 2134

Query: 274  KSQELQNMVEQISLCRAAMGR-SAALRWEEKKALAAAPAAPSQDERVQ 320
              +++Q   E+I      +     AL  E++K   A  A P     VQ
Sbjct: 2135 LQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQ 2182



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 56/248 (22%), Positives = 102/248 (41%), Gaps = 11/248 (4%)

Query: 88   KDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQKE-QMAKLMLQRAERRLR 146
            K + + L   E  RL+ K   +E  L   +L  E K+  E Q   +  K  L R+E R  
Sbjct: 3172 KAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEER-- 3229

Query: 147  EDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQ--EEQRR 204
             D+   E ++  +E QK        L + ++Q + E+ ++     QR    AQ  EEQ R
Sbjct: 3230 -DKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIES--QRMLYDAQLSEEQGR 3286

Query: 205  RCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLA---LLKENQRRKEE 261
              EL   L + + +       +D  +     L+      + R  L    LLKE Q++ EE
Sbjct: 3287 NLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEE 3346

Query: 262  EKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQ 321
            +    +     T+  +L ++  +  + +        L+ E++              +V+ 
Sbjct: 3347 KHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3406

Query: 322  LRRRISER 329
            L+R++ E+
Sbjct: 3407 LQRQLEEK 3414



 Score = 35.8 bits (81), Expect = 0.083
 Identities = 56/255 (21%), Positives = 109/255 (42%), Gaps = 37/255 (14%)

Query: 50  EGALYQR-----QVEQELQRVDKLVDGA-GDFSEFFEWQKKMQAKDREEQLAASECRRLQ 103
           E A+ QR     Q+   LQ+  +  D    +F E  E  +K+Q +   +QL ASE  R  
Sbjct: 197 EAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQF--QQLQASETLRNS 254

Query: 104 GKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRK--ELVEQVIEG 161
              S    +L  +  +  ++Q++E+Q               L ED  +K  +   Q+   
Sbjct: 255 THSSTAADLLQAKQQILTHQQQLEEQDH-------------LLEDYQKKKEDFTMQISFL 301

Query: 162 QKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRA------- 214
           Q+  K  + +  K  + + +E I+E   +++       EE+++  EL  +L         
Sbjct: 302 QEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGE 361

Query: 215 LETQPTRKGKLVD--LTQIPGYGLEGEMSIVELRERLALLKENQRR--KEEEKRDQIIQG 270
           L+ Q  +K + +     ++     +   S  E+++ +  ++E Q+R  K+ +    I+Q 
Sbjct: 362 LQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ- 420

Query: 271 KHTKSQELQNMVEQI 285
                QE Q  +EQ+
Sbjct: 421 --RMEQETQRKLEQL 433



 Score = 35.4 bits (80), Expect = 0.11
 Identities = 60/221 (27%), Positives = 93/221 (42%), Gaps = 19/221 (8%)

Query: 80   EWQKKM---QAKDREEQLAASECRRLQGKLSHEEAVLARQSLMQE-NKQRVE-QQKEQMA 134
            E QKKM   Q+K  + Q    E R+   KL  E   L  Q +MQE  KQ +E ++K +  
Sbjct: 3392 EGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRL--QGIMQEFQKQELEREEKRESR 3449

Query: 135  KLMLQRAER----RLREDRSRKELVEQVIEGQ-KNAKAAQTKLAKGRQQTVQEAIEESRG 189
            +++ Q         L  DR+R  +++Q IEG+ K +  A+     G        +E  R 
Sbjct: 3450 RILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQ 3509

Query: 190  LLQRRAQAAQ-----EEQRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVE 244
             LQ  A   Q       +R + E       +  Q      ++ L ++ G   E E S+V 
Sbjct: 3510 KLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGE-EPSLVS 3568

Query: 245  LRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQI 285
                   L E   R+  E    I Q    K+ +L+NMV ++
Sbjct: 3569 PSTSCGSLTERLLRQNAELTGHISQLTEEKN-DLRNMVMKL 3608



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 50/253 (19%), Positives = 114/253 (45%), Gaps = 26/253 (10%)

Query: 55   QRQVEQELQRVDKLVDGAGDFSE--FFEWQKKMQAKDREEQLAASECRRLQGKLS----H 108
            QR +++  + ++KL     +  +    E +K   A + + +L+     +LQ +       
Sbjct: 2136 QRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV--QLQAERDAIDRK 2193

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
            E+ +   +  +++ ++ +E + E++ +L +Q  E + +E  +R + +EQ     K  K  
Sbjct: 2194 EKEITNLEEQLEQFREELENKNEEVQQLHMQ-LEIQKKESTTRLQELEQE---NKLFKDD 2249

Query: 169  QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQP--TRKGKLV 226
              KL    +++   + ++   L  + AQ  QE++    +L  Q+  L+ Q   T   K++
Sbjct: 2250 MEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVI 2309

Query: 227  DLTQIPGYGLEGEMSIVELRERLALLKENQ---RRKEEEKRDQIIQGKHTKSQELQNMVE 283
            +         E    I +L  ++  L  +Q   +R  EE+ +Q+ +      QEL N+ +
Sbjct: 2310 E---------EKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQ 2360

Query: 284  QISLCRAAMGRSA 296
            + S+   ++   A
Sbjct: 2361 KTSMNAHSLSEEA 2373



 Score = 33.9 bits (76), Expect = 0.32
 Identities = 67/290 (23%), Positives = 120/290 (41%), Gaps = 42/290 (14%)

Query: 47  ILREGALYQRQVE----------QELQRVDKLVDGAGDFSEFFEWQKKMQAKD--REEQL 94
           IL E    QRQ+E          +++QR  + +  A   S+  E  K +   +  + E +
Sbjct: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTI--AEQESKLNEAHKSLSTVEDLKAEIV 576

Query: 95  AASECRRLQGKLSHEEAVL---ARQSLMQENKQRVEQQKEQMAKLMLQRAERRL---RED 148
           +ASE R+ + +L HE  V     +  ++++ K  V  +  +  +  L+R   +L    E+
Sbjct: 577 SASESRK-ELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEE 635

Query: 149 RSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCEL 208
              K   +  IE + N +  +  L    +Q +        GL    +Q  +  Q  +  L
Sbjct: 636 ELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID-------GLQNEMSQKIETMQFEKDNL 688

Query: 209 ISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQII 268
           I++   L  + +   KL DL Q          S+V  +     L+ N+ +KE E   Q  
Sbjct: 689 ITKQNQLILEIS---KLKDLQQ----------SLVNSKSEEMTLQINELQKEIEILRQEE 735

Query: 269 QGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDER 318
           + K T  QE+Q +  +  L    M +      +EK A   A  +  +DE+
Sbjct: 736 KEKGTLEQEVQELQLKTELLEKQM-KEKENDLQEKFAQLEAENSILKDEK 784



 Score = 32.7 bits (73), Expect = 0.71
 Identities = 23/115 (20%), Positives = 55/115 (47%), Gaps = 3/115 (2%)

Query: 166  KAAQTKLAKGRQQTVQ-EAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGK 224
            K  + K+A      +Q EA++E     Q     + E +R   + ++QLR  E        
Sbjct: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISAL 2596

Query: 225  LVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEE--KRDQIIQGKHTKSQE 277
             + ++++    +E   S++  +E++ + ++N   KE++  +  ++++G   K +E
Sbjct: 2597 TLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2651



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 49/221 (22%), Positives = 86/221 (38%), Gaps = 31/221 (14%)

Query: 109  EEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQKNAKAA 168
            EE     Q L++      E   E   +LML  + R         E + +     ++AK  
Sbjct: 1816 EEGTELSQRLVRSGFAGTEIDPEN-EELMLNISSRLQAAVEKLLEAISETSSQLEHAKVT 1874

Query: 169  QTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRKGKLVDL 228
            QT+L +   +  QEA E  +          QEE R R  L  + RA E       K   +
Sbjct: 1875 QTELMRESFRQKQEATESLK---------CQEELRER--LHEESRAREQLAVELSKAEGV 1923

Query: 229  TQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLC 288
              I GY  E  +   +++E+  ++         ++ +Q +     + QEL+   +QI   
Sbjct: 1924 --IDGYADEKTLFERQIQEKTDII---------DRLEQELLCASNRLQELEAEQQQIQEE 1972

Query: 289  RAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISER 329
            R  + R        +K    A A P + + +Q+  + + E+
Sbjct: 1973 RELLSR--------QKEAMKAEAGPVEQQLLQETEKLMKEK 2005



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 46/248 (18%), Positives = 102/248 (41%), Gaps = 30/248 (12%)

Query: 55   QRQVEQELQRVDKLVDGAGDFSEFFEWQKK-----MQAKDREEQLAASECRRLQGKLSHE 109
            + Q+EQ  + ++   +         E QKK     +Q  ++E +L   +  +L   +   
Sbjct: 2201 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKES 2260

Query: 110  EAVLARQS---------LMQENKQRVEQQKEQMAKLMLQ---RAERRLREDRSRKELVEQ 157
            +A+  +           ++QE +  ++Q  EQ+ KL  Q     + ++ E+++  EL+  
Sbjct: 2261 DAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKN--ELIRD 2318

Query: 158  VIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALET 217
            +    +   + Q  + + R++ +++  E    L Q  A   Q+       L  +  +L+ 
Sbjct: 2319 LETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKH 2378

Query: 218  QPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQE 277
            Q         L  +    L  E  +    E +  +K N  ++   K +Q+ Q   +  +E
Sbjct: 2379 Q---------LDVVIAEKLALEQQVETANEEMTFMK-NVLKETNFKMNQLTQELFSLKRE 2428

Query: 278  LQNMVEQI 285
             ++ VE+I
Sbjct: 2429 RES-VEKI 2435


>gi|134152708 arginine and glutamate rich 1 [Homo sapiens]
          Length = 273

 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 43/144 (29%), Positives = 75/144 (52%), Gaps = 18/144 (12%)

Query: 79  FEWQKKMQAKDREEQLAASECRR----LQGKLSHEEAVLARQSLMQENKQRVEQQKEQMA 134
           FE Q+K++ ++ EE+L   E  R    L  K   EE    +  + +E  +RVE+ K  M 
Sbjct: 110 FERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIME 169

Query: 135 KLMLQRAER-----------RLREDRSRKELVEQVI-EGQKNAKAAQTKLAKGRQQTVQE 182
           K +L+  ER           R  E+R+++E +E+++ E  +    AQ KLA+ + + V+E
Sbjct: 170 KQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEE 229

Query: 183 --AIEESRGLLQRRAQAAQEEQRR 204
              I E R  L++  Q  Q+E+++
Sbjct: 230 QRKIHEERMKLEQERQRQQKEEQK 253



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 50/203 (24%), Positives = 100/203 (49%), Gaps = 31/203 (15%)

Query: 88  KDREEQLAASECRRLQGKLSHEEAVLARQSLMQENKQRVEQQK---EQMAKLMLQRAERR 144
           ++R+ + A+S   R+         V  R SL ++ K+  E++K   E+  K+  Q  E +
Sbjct: 68  RERDRERASSPPDRID---IFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEK 124

Query: 145 LREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEA---IEESRGLLQRRAQAAQEE 201
           L E+ + + + E V      AK  + +L K + +  +E    +EE++ +++++     E 
Sbjct: 125 LIEEETARRVEELV------AKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELER 178

Query: 202 QRRRCELISQLRALETQPTRKGKLVDLTQIPGYGL--------EGEMSIVELR-----ER 248
           QR+  EL +Q    E +  ++ +L  + +     +        E ++ IVE +     ER
Sbjct: 179 QRQ-AELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEER 237

Query: 249 LALLKENQRRKEEEKRDQIIQGK 271
           + L +E QR+++EE++  II GK
Sbjct: 238 MKLEQERQRQQKEEQK--IILGK 258



 Score = 37.0 bits (84), Expect = 0.037
 Identities = 35/175 (20%), Positives = 80/175 (45%), Gaps = 16/175 (9%)

Query: 162 QKNAKAAQTKLAK-GRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPT 220
           + ++++  TK +K  ++++   +    +  +++R+++ + ++ RR E  S+ R+  T  +
Sbjct: 7   RSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVS 66

Query: 221 RKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQELQN 280
           R+ +  +    P   ++     V  R  L    E Q+R+EEEK+ +  + +  + QE++ 
Sbjct: 67  RRERDRERASSPPDRIDIFGRTVSKRSSL---DEKQKREEEEKKAEFERQRKIRQQEIEE 123

Query: 281 MVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSR 335
            +         +    A R EE   L A       ++R  ++ R +  R  E  R
Sbjct: 124 KL---------IEEETARRVEE---LVAKRVEEELEKRKDEIEREVLRRVEEAKR 166


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 61/299 (20%), Positives = 131/299 (43%), Gaps = 19/299 (6%)

Query: 48  LREGALYQRQVEQELQRVDKLV---DGAGDFSEFFEWQKKMQAKDREEQLAASE--CRRL 102
           +RE     R+ E++++R ++++   +      E   W+K+ + +  EE +   E   R L
Sbjct: 323 IREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIREL 382

Query: 103 QGKLSHEEAVLARQSLMQENKQRVEQQKEQMAKLMLQRAERRLREDRSRKELVEQVIEGQ 162
           + K+  +E +  ++   QE ++  EQ+K Q  +  + R E ++RE   +    E+ +  Q
Sbjct: 383 EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ 442

Query: 163 KNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRK 222
           +     Q K+ +  ++  QE +       Q      QEE  R+ E + +   +  Q  + 
Sbjct: 443 EEKIHEQEKIREEEKRQEQEEMWR-----QEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497

Query: 223 GKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQIIQGKHTKSQE-LQNM 281
            +  +         + E  I E  E++   +E  R +EE+ R+Q  + K  + +E +Q  
Sbjct: 498 WRQEEKMH------DQEEKIREQEEKMWRQEEKIREQEEKIREQ--EEKIREQEEMMQEQ 549

Query: 282 VEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERVQQLRRRISERAAERSRQAALL 340
            E++      M     +R +E+K          Q E++++   +I E+  +   Q  ++
Sbjct: 550 EEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMM 608



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 68/370 (18%), Positives = 152/370 (41%), Gaps = 61/370 (16%)

Query: 9   VQGSKQQLRLQFPPRIRKTPKLTFYRPDNIL-------------VKLNTTAILREGALYQ 55
           V+  K +++L      RK  +     P   L             V     A + E  L+ 
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWN 292

Query: 56  R---QVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKLSHEEAV 112
           R   Q E+++ R ++ +          EW++K+Q ++ + +    + R  + K+  +E +
Sbjct: 293 RLNQQQEEKMWRQEEKIQ---------EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343

Query: 113 L-ARQSLMQENKQRVEQQKEQMAKL--MLQRAERRLRE------------DRSRKELVEQ 157
           +  ++  M+  ++ + +++E+M +L  M+   E ++RE            ++  K   E+
Sbjct: 344 MWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEE 403

Query: 158 VIEGQKNAKAAQTKL----AKGRQQ------------TVQEAIEESRGLLQRRAQAAQEE 201
            I  Q+  +  + K+     K R+Q              +E I E   + +   +  QEE
Sbjct: 404 KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEE 463

Query: 202 QRRRCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEE 261
             R+ E I +   +  Q  +  +   + +        E  + +  E++   +E   R+EE
Sbjct: 464 MWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEE 523

Query: 262 EKRDQ--IIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWEEKKALAAAPAAPSQDERV 319
           + R+Q   I+ +  K +E + M+++       MG       E++K          Q+E++
Sbjct: 524 KIREQEEKIREQEEKIREQEEMMQE---QEEKMGEQEEKMQEQEKMRRQEEKIREQEEKI 580

Query: 320 QQLRRRISER 329
           ++ + +I E+
Sbjct: 581 REQKEKIREQ 590



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 45/243 (18%), Positives = 113/243 (46%), Gaps = 16/243 (6%)

Query: 48  LREGALYQRQVEQELQRVDKLVDGAGDFSEFFEWQKKMQAKDREEQLAASECRRLQGKL- 106
           +RE      + E+++   +K+ +      +   W+++ + +++EE     E    Q K+ 
Sbjct: 432 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIR 491

Query: 107 SHEEAVLARQSLMQENKQRVEQQKEQMAKL--MLQRAERRLREDRSRKELVEQVIEGQKN 164
             EE V  ++  M + ++++ +Q+E+M +    ++  E ++RE   +    E++++ Q+ 
Sbjct: 492 KQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEE 551

Query: 165 AKAAQTKLAKGRQQT--VQEAIEESRGLLQRRAQAAQEEQRRRCELISQLRALETQPTRK 222
               Q +  + +++    +E I E    ++ + +  +E++ +  E   ++R  E     +
Sbjct: 552 KMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQ 611

Query: 223 GKLVDLTQIPGYGLEGEMSIVELRERLALLKENQRRKEEEKRDQII--QGKHTKSQELQN 280
            + +          E E  + E  E++   +E  RR+EE+  +Q +  + +  K QE Q 
Sbjct: 612 EEKM---------WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662

Query: 281 MVE 283
            +E
Sbjct: 663 HLE 665



 Score = 33.5 bits (75), Expect = 0.41
 Identities = 40/202 (19%), Positives = 84/202 (41%), Gaps = 18/202 (8%)

Query: 142 ERRLREDRSRKELVEQVIEGQKNAKAAQTKLAKGRQQTVQEAIEESRGLLQRRAQAAQEE 201
           E+ L    ++K+  ++ IE     + A + L   R     E ++E    LQ + Q  + E
Sbjct: 178 EQALSAVATQKKKADRYIEELTKERDALS-LELYRNTITDEELKEKNAKLQEKLQLVESE 236

Query: 202 QRR-------------RCELISQLRALETQPTRKGKLVDLTQIPGYGLEGEMSIVELRER 248
           +               R +L+   + L+ +    GK +   Q     L+ ++   EL  R
Sbjct: 237 KSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL---QSVSAKLQAQVEENELWNR 293

Query: 249 LALLKENQRRKEEEKRDQIIQGKHTKSQELQNMVEQISLCRAAMGRSAALRWE-EKKALA 307
           L   +E +  ++EEK  +  +    + ++++   E+I      M R   + WE E+K   
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353

Query: 308 AAPAAPSQDERVQQLRRRISER 329
                  ++E++++L   + E+
Sbjct: 354 QEEMMWEKEEKMRRLEEMMWEK 375


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,759,771
Number of Sequences: 37866
Number of extensions: 864215
Number of successful extensions: 11178
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 197
Number of HSP's successfully gapped in prelim test: 914
Number of HSP's that attempted gapping in prelim test: 7142
Number of HSP's gapped (non-prelim): 3072
length of query: 459
length of database: 18,247,518
effective HSP length: 106
effective length of query: 353
effective length of database: 14,233,722
effective search space: 5024503866
effective search space used: 5024503866
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.